bluuebunny/crossref_metadata_2025 huggingface dataset:
THEORETICAL ASPECTS OF FORENSIS-PSYCHOLOGICAL EXAMINATION OF TYPOLOGICAL FEATURES OF PERSONALITY
Authors: Slipets O.
Published: April 2020

Over more than a hundred years of history of the application of psychological knowledge to resolve issues of law remains a controversial series of theoretical provisions of forensic psychological examination. This is also true for the psychological examination of individual psychological (typological) features of the person.
The purpose of the article is to formulate theoretical provisions of forensic psychological examination of typological features of a person, main concepts.
Based on the definition of the object and subject of forensic psychological examination, the concept of object and subject of psychological examination of typological features of a person is formulated. On the basis of an analysis of the legal significance of the psychological study of a person of a suspect (accused) in criminal and administrative proceedings, the legal significance and tasks of forensic psychological examination of typological peculiarities are formulated. Proceeding from the subject of psychology, the legal significance of psychological facts for establishing legal criteria, the standardized requirements for qualification and the behavior of an expert, it is proposed to clarify the limits of competence of an expert psychologist. A means of applying the notion-limiter to general psychological categories, the definition of the basic concepts of forensic psychological examination typological features of the person.
The theoretical provisions of the forensic psychological examination of psychological peculiarities of a person are formulated: object, subject, legal significance, tasks, limits of competence, thesaurus, is an element of the system of theoretical and methodical foundations of forensic psychological examination and the basis for the creation of a method of forensic psychological examination of typological features of a person .
TO THE QUESTION OF AN INTEGRATED RESEARCH OF BIOLOGICAL DAMAGE TO FIBROUS MATERIALS BY THE METHOD OF RASTER ELECTRON MICROSCOPY
Authors: Balinyan T. , Derecha L. , Nosatenko Yu.
Published: April 2020

The article considers the need for a comprehensive study of biological damage to fibrous materials by scanning electron microscopy. The main types and characteristics of fibers and fibrous materials, their types of damage, in particular, biological, and the mechanism of their formation are described. It is shown that with modern methods for studying morphological characteristics, the most effective is the method of scanning electron microscopy, which makes it possible to directly study the object in a wide range of magnifications. The use of scanning electron microscopy makes it possible to identify qualitatively new volumetric microsigns when conducting studies of fibrous materials. Biological damage agents (biofactors) are considered — microbiological (bacteria, microbes, fungi, blue-green algae), phytological (mosses, lichens, higher plants, algae), zoological (insects, birds, mammals). Attention is focused on the study of injuries caused by mold caused by moths, dogs, etc.
Conducting a comprehensive study of various types of damage to materials of various fibrous nature allows us to obtain an information database, the possibility of differentiating chemical, mechanical, thermal and biological damage, identifying microsigns that individualize one or another object (factor) of action, influence, increasing the potential for obtaining trace information about the actual data and circumstances of the event in those cases when only by external morphological features of the diagnosis It is not possible to repair damage. The data obtained indicate the effectiveness of the chosen research area. The results of the studies are positive for creating the optimal research scheme, methods of microscopic studies of damage to materials of fibrous nature in order to solve diagnostic, identification and situational tasks of forensic examination.
环保监测中空气污染监测点的布设分析
Authors: 胡 建琴 , 洪 毓
Published: April 2020

现阶段,在世界范围内环境污染问题越来越严重,而针对环境污染问题进行治理的过程中,切实有效的贯彻落实可持续发展战略,是解决污染问题的最重要途径。目前,我国极力提倡建设资源节约型、环境友好型社会,在这样的新时代背景下,人们也越来越关注环保监测中空气污染监测点布设等相关问题,为了从根本上有效掌握城市的整体污染情况,空气污染监测点科学合理的布设是至关重要的。针对这种情况,本文有针对性的探究环保监测中空气污染监测点的布设等相关内容,为同行提供参考。
O Trabalho dos Profissionais de Enfermagem em Unidades de Terapia Intensiva na Assistência ao Paciente Oncológico
Authors: Machado Hercos Thaíse , De Siqueira Vieira Flávia , Silva de Oliveira Marissa , Scatralhe Buetto Luciana , Megumi Naka Shimura Camila , Megumi Sonobe Helena
Published: April 2020

Introdução: Os profissionais que atuam na Oncologia lidam com sofrimento, dor e muitas vezes com a morte. Objetivos: Identificar os fatores que influenciam a atuação dos profissionais de enfermagem em unidades oncológicas e estratégias que favoreçam a assistência ao paciente oncológico na literatura. Método: Trata-se de uma revisão integrativa, com busca nas bases de dados Lilacs e Medline com os descritores: enfermagem oncológica, burnout, estresse, profissionais de saúde e Unidade de Terapia Intensiva (UTI). Resultado: A análise de dados revelou dois temas: “o contexto de cuidado do paciente oncológico na UTI”, no qual evidenciaram-se os vários fatores que podem influenciar negativamente o trabalho da equipe multiprofissional na UTI oncológica, tanto fatores físicos como psicológicos; e o “os sentimentos dos profissionais na assistência ao paciente oncológico na UTI”, no qual revela o conflito entre o dever de manter a vida versus o processo de finitude. Há estratégias para minimizar os fatores estressantes como melhorar as condições de trabalho e suporte psicológico. Conclusão: Futuros estudos devem ser realizados para melhorar o relacionamento profissional na UTI, pois a melhoria da qualidade de vida de toda a equipe, que cuida do paciente oncológico e de sua família, influencia na qualidade e humanização da assistência prestada.
Estudo da Expressão de Genes relacionados com o Fuso Mitótico (AURKA e AURKB) e Ponto de Checagem Mitótico (CDC20 e MAD2L1) em Pacientes Portadores de Síndrome Mielodisplásica
Authors: Fernandes Heredia Fabiola , Feitosa Pinheiro Ronald
Published: April 2020

Introdução: Estudos mostram que alterações na expressão de genes relacionados ao fuso mitótico (AURKA e AURKB) e ponto de checagem mitótico (CDC20 e MAD2L1) estão envolvidas na instabilidade cromossômica e progressão da doença em tumores sólidos e hematológicos. Objetivo: Avaliar o perfil de expressão desses genes em pacientes com síndrome mielodisplásica (SMD), e investigar sua relação com variáveis clinicas/laboratoriais da doença. Método: Amplificação dos genes AURKA e AURKB realizada por FISH e expressão de AURKA, AURKB, CDC20 e MAD2L1 realizada por qRT -PCR em 61 amostras de medula óssea (MO) de pacientes com SMD, oriundos do Hospital Universitário Walter Cantídio (CEP/HUWC No075.11.08). Amostras de MO de dez voluntários sadios constituiu o grupo controle. Resultados: Amplificação de AURKA foi observada em 10% dos casos, os quais também mostraram expressão mais elevada do que o controle (p=0,038). Pacientes com MO normo/hipercelular apresentaram maior expressão que pacientes com MO hipocelular (p=0,0016; 0,0010; 0,0001; <0,0001 para AURKA, AURKB, CDC20 e MAD2L1, respectivamente). Após regressão logística multinominal, os resultados mostraram associação entre níveis elevados de expressão dos genes estudados e risco aumentado de desenvolver SMD normo/hipercelular. Também indicaram que a idade (pacientes ≥60 anos) está associada com níveis elevados de expressão de AURKA, CDC20 e MAD2L1. Conclusão: A expressão distinta dos pacientes hipocelulares enfatiza a importância prognostica da celularidade na SMD e reforça a diferente patogênese dessa entidade. A amplificação e expressão elevada de AURKA sugerem que o aumento da expressão desse gene esteja relacionado com a patogênese da SMD.
Estado, pequeños productores y nuevas territorialidades : un estudio de caso.
Authors: De la Torre Delia Inés , Moscheni Margarita
Published: April 2020

La financiarización de la economía global genera procesos de desarrollo heterogéneos, con agentes exportadores altamente competitivos junto a otros más vulnerables orientados principalmente al mercado interno. Todo ello en un mismo territorio, en el que la puja por la apropiación y control de sus recursos, tanto simbólicos como materiales, configuran procesos conflictivos, determinados por relaciones asimétricas de dominación. El Estado, como relación social, tiene como rol principal garantizarla a través de sus dos funciones principales: la de acumulación y la de legitimación. En el ejercicio de ésta última, facilita la configuración de tramas y redes productivas de grupos subalternos, que logran construir territorialidades locales y que dejan huellas en el territorio. Este trabajo tiene como propósitos desentrañar el proceso de territorialidad de los grupos subalternos, analizando una experiencia de desarrollo productivo y describir el papel del Estado actuando y sosteniendo dichas redes. Para ello se presenta como estudio de caso una experiencia asociativa de agricultores familiares productores de melón, de la provincia de San Juan (Argentina). Se trata de un trabajo descriptivo, con triangulación metodológica de datos cualitativos (entrevistas a funcionarios, técnicos y productores), y datos cuantitativos (censos), que aspira a caracterizar casos que configuran nuevos territorios desde abajo hacia arriba. Asimismo, se plantean lineamientos de políticas estatales que intentan ser un aporte para el sector, que surgen no sólo de la experiencia analizada sino del proyecto de investigación que enmarca este artículo.
EFFECTS OF INQUIRY-BASED TEACHING ON CHINESE UNIVERSITY STUDENTS’ EPISTEMOLOGIES ABOUT EXPERIMENTAL PHYSICS AND LEARNING PERFORMANCE
Authors: Shi Wei-Zhao , Ma Liping , Wang Jingying
Published: April 2020

Students' epistemologies of experimental physics refer to how they understand the role of experimentation as well as the experimental operation and design and communication of results in physics. This research aimed to find whether students in inquiry-based physics laboratory activities show more expert-like epistemologies of experimental physics and better course performance relative to courses using cookbook guided laboratory activities. The participants consisted of two classes of students in a Chinese university. They were divided into control group and experimental group. The experimental group was taught with inquiry-based teaching, while the control group was using cookbook teaching. Each group was taught by the same lecturer. Colorado Learning Attitudes about Science Survey for Experimental Physics were used to investigate students’ epistemologies about the nature of experimental physics. It was found that students in a traditional cookbook guided laboratory showed significant negative shifts on personal epistemologies, and in contrast, students’ epistemologies of experimental physics in inquiry-based laboratory had been significantly improved. The increase of scores in the control group was higher than the experiment group on experimental physics learning performance. The results were slightly different from other studies, some possible explanations were given.
Keywords: epistemologies of experimental physics, inquiry-based teaching, physics education
STUDENTS’ ABILITY TO WORK WITH GRAPHS IN PHYSICS STUDIES RELATED TO THREE TYPICAL STUDENT GROUPS
Authors: Skrabankova Jana , Popelka Stanislav , Beitlova Marketa
Published: April 2020

Graphs are often used to represent mathematical functions, to illustrate data from social and natural sciences, or to specify scientific theories. With increasing emphasis on the development of scientific research skills, the work with graphs and data interpretation are gaining in importance. The research involved an eye-tracking experiment conducted to evaluate student work with graphs in physics. Eye-movement data were recorded using the GazePoint eye-tracker. A total of 40 third-year grammar school students participated in the research. These students were allocated into three groups by a physics teacher. These groups were called PLUS, AVERAGE and MINUS. The PLUS group showed excellent results in education and included gifted physics students. The MINUS group was composed of the opposite end of this cognitive spectrum, whose members made the most mistakes in graph reading. The aim of the experiment was to find the differences between students allocated to these three groups and to evaluate whether the allocation based on the teacher’s experience, long-term observations and the students’ previous achievements was sufficient. The results showed that students from all three groups had problems with reading graphs in physics. According to the eye-movement data, several students who had been incorrectly assigned to groups were identified. Keywords: education in physics, gifted children, graph, eye-tracking, experimental study.
PENGARUH KUALITAS PELAYANAN, HARGA DAN KEPUASAN TERHADAP LOYALITAS PASIEN (Studi Kasus Pada Pasien Rawat Jalan Rumah Sakit Premier Bintaro)
Authors: Arianto Nurmin
Published: April 2020

The needs of service quality hospital intensified as the improvement of the economy and the degree of community health by the Hospital Premier Bintaro must be able to provide quality service oriented to the achievement of customer satisfaction of patients who will eventually cause patients who are loyal. This research aims to find out the influence of the service quality, price and customer satisfaction and loyalty patients. Samples in detail is 100 patients outpatients. Analysis of the data used a validity test and reliability test, classical assumptions, double linear regression, determination coefficient and testing the hypothesis. The research results obtained that the service quality, price and customer satisfaction have impact on customer loyalty good patients partially or simultanously. And to improve the quality of service then increased more focused in terms of reliability and assurance, to increase the value of the offered prices and review more focused at affordable prices and the suitability of the price with the benefits and facilities and improve customer satisfaction patients more focused to the comfort and security of patients so that patients really feel satisfied and loyal to the hospital.Kebutuhan akan layanan rumah sakit bermutu semakin meningkat seiring membaiknya perekonomian dan derajat kesehatan masyarakat oleh maka dari itu Rumah Sakit Premier Bintaro harus dapat memberikan pelayanan yang berkualitas berorientasi pada tercapainya kepuasan pasien yang akhirnya akan menyebabkan pasien yang loyal. Penelitian ini bertujuan untuk mengetahui pengaruh kualitas pelayanan, harga dan kepuasan terhadap loyalitas pasien.Sampel yang di teliti adalah 100 pasien rawat jalan. Analisis data yang digunakan uji validitas dan reliabilitas, uji asumsi klasik,regresi linear berganda, koefisien determinasi dan pengujian hipotesis. Hasil penelitian diperoleh bahwa kualitas pelayanan, harga dan kepuasan memiliki pengaruh terhadap loyalitas pasien baik secara parsial maupun simultan. Dan untuk meningkatkan kualitas pelayanan maka peningkatan lebih difokuskan dalam hal reliability dan assurance, untuk meningkatkan nilai harga yang ditawarkan maka pengkajian ulang lebih difokuskan keterjangkauan harga serta kesesuaian harga dengan manfaat dan fasilitas dan  meningkatan kepuasan pasienlebih difokuskan kepada kenyamanan dan keamanan terhadap pasienagar pasien benar-benar merasa puas danloyal terhadap rumah sakit.
ANALISIS BEBAN KERJA TERHADAP KEBUTUHAN PEGAWAI ADMINISTRASI DALAM MENJAMIN OPTIMALISASI OPERASIONAL AKADEMIK
Authors: Yusuf Yusuf , Anfas Anfas , Sudarwo Raden
Published: April 2020

The number of employees needs to be based on the workload of administrative staff UPBJJ-UT Ternate. To calculate the activity time employees who used to work and time are not, researchers using work sampling table. Methods of calculating labor requirements are based on the calculation of the workload with the approach per duties of office according MenPAN No. KEP/75/M.PAN/7/2004 on Guidelines for Employee Needs Calculation based Workload in the framework of preparation of formation of civil servants. Samples were UPBJJ-UT Ternate employee status with the principal administrative officer jobs based Target Achievement Quality Employees (CSKP). Calculation and data processing using Microsoft Excel. The study concluded that there is a significant result in the use of working time and to have the results of the number of employees needed for the actual number of employees, it is known that there are 7 functions of employees, unit administrative KTU has an excess number of employees as much as 1 employee and BPP has a shortage of employees as many as 1 employee. For registration and testing PDA unit has a shortage of the number of employees as much as 1 employee.

 

Jumlah kebutuhan pegawai harus didasarkan kepada beban kerja pegawai administrasi UPBJJ-UT Ternate. Untuk menghitung waktu aktifitas pegawai yang digunakan untuk bekerja dan waktu yang tidak, peneliti menggunakan tabel work sampling. Metode perhitungan kebutuhan tenaga kerja didasarkan pada perhitungan beban kerja dengan pendekatan per tugas jabatan sesuai Keputusan MenPAN Nomor: KEP/75/M.PAN/7/2004 tentang Pedoman Perhitungan Kebutuhan Pegawai berdasarkan Beban Kerja dalam rangka Penyusunan Formasi PNS. Sampel penelitian adalah pegawai UPBJJ-UT Ternate berstatus pegawai administrasi dengan pokok pekerjaan didasarkan Capaian Sasaran Kualitas Pegawai (CSKP). Perhitungan dan pengolahan data menggunakan Microsoft Excel. Penelitian ini menyimpulkan bahwa terdapat hasil yang signifikan pada penggunaan waktu kerja dan memiliki hasil jumlah karyawan yang dibutuhkan terhadap jumlah aktual karyawan, dapat diketahui bahwa terdapat 7 fungsi karyawan, unit tata usaha KTU memiliki kelebihan jumlah karyawan sebanyak 1 orang karyawan dan BPP memiliki kekurangan jumlah karyawan sebanyak 1 orang karyawan. Untuk unit registrasi dan pengujian PDA memiliki kekurangan jumlah karyawan sebanyak 1 orang karyawan.
ANALISIS FINANCIAL DISTRESS PADA PT TUNAS BARU LAMPUNG TBK DI BURSA EFEK INDONESIA
Authors: Ambarwati Umi , Sudarwati Sudarwati , Widayanti Rochmi
Published: April 2020

This article aims to analyze the health of the company in PT Tunas Baru Lampung TBK in Indonesia Stock Exchange. The data comes from PT Tunas Baru Lampung TBK in 2013-2015. The methods used are Altman Z-Score, Springate, Zmijewski and Fulmer methods. The results of the study show that there are differences in predicted bankruptcy results between the Altman Z-score method, Springate, Zmijewski and Fulmer. This is due to differences in the use of financial ratios and criteria bankruptcy between Altman Z-score, Springate, Zmijewski and Fulmer. For that company is expected to increase sales, perform effective strategies, reduce operational costs to be more efesian so that companies can meet the company's health criteria.

 

Artikel ini bertujuan untuk menganalisis kesehatan perusahaan pada PT Tunas Baru Lampung TBK di Bursa Efek Indonesia. Data berasal dari PT Tunas Baru Lampung TBK pada tahun 2013-2015. Metode yang digunakan adalah metode Altman Z-Score, Springate, Zmijewski dan Fulmer. Hasil penelitian menunjukkan adanya perbedaan hasil prediksi kebangkrutan antara metode Altman Z-score, Springate, Zmijewski dan Fulmer. Hal ini karena adanya perbedaan penggunaan rasio keuangan dan kriteria kebangkrutan antara Altman Z-score, Springate, Zmijewski dan Fulmer. Untuk itu perusahaan diharapkan meningkatkan penjualan, melakukan strategi yang efektif, menekan biaya operasional agar lebih efesian sehingga perusahaan dapat memenuhi kriteria kesehatan perusahaan.
Analysis of Knowledge Sharing Using Canonical Correlation Toward Organizational Innovation
Authors: Supartini Vebi Dewi , Sukmawati Anggraini , Anggraeni Elisa
Published: April 2020

This paper is based on the importance of knowledge sharing to create innovation in an organization to overcome the problem of PTPN competition with the private sector. The purpose of this study is to determine the relationship between knowledge sharing variables, which are tacit knowledge sharing and explicit knowledge sharing, on innovation variables, which are speed innovation and quality innovation. The data collection method used a questionnaire with a sample of 100 employees and data were analyzed using canonical correlation analysis. The results of the study showed that there was an influence on each variable. Explicit knowledge sharing had influence on the speed and quality of innovation and explicit knowledge sharing had influence on the speed and quality of innovation. Conclusions from this study were that both variables had a strong relationship, so companies can consider these variables in strategic planning.
SMEs Development Strategy of Footwear Business
Authors: Ibrahim Syufriadi , Ridho Nurrochmat Dodik , Maulana Agus
Published: April 2020

The main objective of this research is to analyze the strategy of developing the footwear business. Case studies were carried out at CV Hikmah Shoes Bogor. The initial analysis was carried out by identifying the business of the ongoing CV Hikmah Shoe model and analyzing the external and internal scope to identify problems that occurred in the company. The descriptive method used to identify CV Hikmah Shoes Bogor using, Internal Factor Matrix (IFE) and External Evaluation Factor (EFE) used to analyze internal and external factors at CV Hikmah Shoesr. SWOT matrix selected to determine the strategy to be implemented and Quantitative Strategy Planning Matrix (QSPM) is used as a process to determine strategic priorities for the company. The results of the SWOT Matrix in this study produced six alternative strategies that were chosen as development strategies at CV Hikmah Shoes, Bogor. results The best strategy taken in developing the footwear business is to maximize promotion and marketing using social media or e-commerce and to continue with the improvement business.
PHUBBING BEHAVIOR AND ROMANTIC RELATIONSHIP: MECHANISM OF MENTAL HEALTH AMONG MARRIED COUPLES
Authors: Zonash Mir Rabia
Published: April 2020

Does Phubbing Behavior and Romantic Relation leads to Mental Health issues among married couple? The present study intended to explore the effect of how phubbing behavior and romantic relationships are affecting mental health of married couples. For the study purpose a sample of 120 Married couples were taken between the age ranges 20-60 years of age. Partner Phubbing Rating Scale developed by Roberts and David (2015) was used to measure phubbing behavior among married couples. Romantic Partner Scale (RPS) developed by Zacchilli, Hendricks, and Hendricks, (2012) was applied to assess the romantic relationship between both partners and the third scale used was short form of Mental Health Continuum developed by Keyes (2005) in order to assess the mental health issue among married couples. Phubbing behavior positively predicted interactional activity and negatively predicts compromise, avoidance, separation, dominance and submission. Phubbing behavior negatively predicts mental health among married couples. Gender difference indicates that males are higher on romantic relationship as well as mental health as compared to females. As far as demographic variables are concerned, based on the findings of current research, it was concluded that there was no gender differences found in phubbing behavior, romantic relationship, and mental health of married couples. Phubbing behavior is significantly higher in love marriage couples in comparison with arranged marriage couples.
Influence of Socio-Demographic Features on Piri-Muridi: An Experiential Study
Authors: Younas Sana , Kamal Dr.Anila
Published: April 2020

The present study explored the role of socio-demographic factors with Piri-Muridi within indigenous context of Pakistan. Participants (N = 291) were taken from Islamabad, Rawalpindi, Azad Kashmir, and Mansehra. Their age ranged from 18-73 years (M = 30.38, SD = 10.74). Piri-Muridi scale (Hassan & Kamal, 2010) was used to assess the mean differences across various demographic factors. Results revealed that women are more inclined towards Piri-Muridi and have more perception of negative change in Piri-Muridi as compared to men. Married individuals scored significantly higher as compared to single individuals on the facets of belief system about Piri-Muridi. Older aged adults scored significantly higher on the domain of Piri-Muridi and belief system about Piri-Muridi. Post hoc analysis revealed that participants having less education have more favorable attitude towards Piri-Muridi as compared to those having high level education. Murids have strong belief in Piri-Muridi as compared to situational believers of Piri-Muridi and non-believers of Piri-Muridi. Non-believers of Piri-Muridi have more negative perception of change in Piri-Muridi as compared to strong believers and Murids. Ahly hades sect showed strong negative perception regarding Piri-Muridi as compared to Ahly sunnat brelvi. Findings are discussed with reference to pertinent literature and suggestions have been given for future researchers.
Sustainability: Obtaining Natural Dyes from Waste Matrices Using the Prickly Pear Peels of Opuntia ficus-indica (L.) Miller
Authors: Scarano Pierpaolo , Naviglio Daniele , Prigioniero Antonello , Tartaglia Maria , Postiglione Alessia , Sciarrillo Rosaria , Guarino Carmine
Published: April 2020

In this work, the effect of dyes extracted through the Naviglio method (an eco-innovative solid-liquid extraction technique) was tested, which proved interesting for such an extraction. The dyes extracted from Opuntia ficus-indica (L.) Miller waste were treated to maximize the extraction of the coloring molecules. The extraction method was compared with conventional methods under the same conditions. The results showed that the extracts obtained with the different techniques, in the same extraction conditions (solvent, pH, temperature, time), were richer in the pigments for the extract obtained with the Naviglio method. The stability of the dyes was tested before the staining. A plant-based fiber, cotton, as well as an animal-based fiber, wool, were chosen for the staining tests. For the two types of fiber, two etching methods were used: one with rock alum, a method widely used to fix a color and one with lemon juice, a method used for a long time by rural populations who practiced the coloring of hides and tissues. In addition, the qualitative content of the pigments was also verified with an HPLC profile of the Opuntia ficus-indica (L.) Miller extracts. Ultimately, the results suggest that the Opuntia ficus-indica (L.) Miller fruit can be of great interest as a natural source of dyes and be used for tinctures.
Locality-Sensitive Hashing for Information Retrieval System on Multiple GPGPU Devices
Authors: Nguyen Mau Toan , Inoguchi Yasushi
Published: April 2020

It is challenging to build a real-time information retrieval system, especially for systems with high-dimensional big data. To structure big data, many hashing algorithms that map similar data items to the same bucket to advance the search have been proposed. Locality-Sensitive Hashing (LSH) is a common approach for reducing the number of dimensions of a data set, by using a family of hash functions and a hash table. The LSH hash table is an additional component that supports the indexing of hash values (keys) for the corresponding data/items. We previously proposed the Dynamic Locality-Sensitive Hashing (DLSH) algorithm with a dynamically structured hash table, optimized for storage in the main memory and General-Purpose computation on Graphics Processing Units (GPGPU) memory. This supports the handling of constantly updated data sets, such as songs, images, or text databases. The DLSH algorithm works effectively with data sets that are updated with high frequency and is compatible with parallel processing. However, the use of a single GPGPU device for processing big data is inadequate, due to the small memory capacity of GPGPU devices. When using multiple GPGPU devices for searching, we need an effective search algorithm to balance the jobs. In this paper, we propose an extension of DLSH for big data sets using multiple GPGPUs, in order to increase the capacity and performance of the information retrieval system. Different search strategies on multiple DLSH clusters are also proposed to adapt our parallelized system. With significant results in terms of performance and accuracy, we show that DLSH can be applied to real-life dynamic database systems.
Many-Body Effects in FeN4 Center Embedded in Graphene
Authors: Allerdt Andrew , Hafiz Hasnain , Barbiellini Bernardo , Bansil Arun , Feiguin Adrian E.
Published: April 2020

We introduce a computational approach to study porphyrin-like transition metal complexes, bridging density functional theory and exact many-body techniques, such as the density matrix renormalization group (DMRG). We first derive a multi-orbital Anderson impurity Hamiltonian starting from first principles considerations that qualitatively reproduce generalized gradient approximation (GGA)+U results when ignoring inter-orbital Coulomb repulsion U ′ and Hund exchange J. An exact canonical transformation is used to reduce the dimensionality of the problem and make it amenable to DMRG calculations, including all many-body terms (both intra- and inter-orbital), which are treated in a numerically exact way. We apply this technique to FeN 4 centers in graphene and show that the inclusion of these terms has dramatic effects: as the iron orbitals become single occupied due to the Coulomb repulsion, the inter-orbital interaction further reduces the occupation, yielding a non-monotonic behavior of the magnetic moment as a function of the interactions, with maximum polarization only in a small window at intermediate values of the parameters. Furthermore, U ′ changes the relative position of the peaks in the density of states, particularly on the iron d z 2 orbital, which is expected to affect the binding of ligands greatly.
A Case Study about Biomass Torrefaction on an Industrial Scale: Solutions to Problems Related to Self-Heating, Difficulties in Pelletizing, and Excessive Wear of Production Equipment
Authors: Nunes Leonel J.R.
Published: April 2020

The search for different forms of biomass that can be used as an alternative to those more traditional ones has faced numerous difficulties, namely those related to disadvantages that the majority of residual forms present. However, these residual forms of biomass also have advantages, namely the fact that, by being outside the usual biomass supply chains for energy, they are usually much cheaper, and therefore contribute to a significant reduction in production costs. To improve the less-favorable properties of these biomasses, thermochemical conversion technologies, namely torrefaction, are presented as a way to improve the combustibility of these materials. However, it is a technology that has not yet demonstrated its full potential, mainly due to difficulties in the process of scale-up and process control. In this article it is intended to present the experience obtained over 5 years in the operation of a biomass torrefaction plant with an industrial pilot scale, where all the difficulties encountered and how they were corrected are presented, until it became a fully operational plant. This article, in which a real case study is analyzed, presents in a descriptive way all the work done during the time from when the plant started up and during the commissioning period until the state of continuous operation had been reached.
Construction of Alizarin Conjugated Graphene Oxide Composites for Inhibition of Candida albicans Biofilms
Authors: Ramasamy Mohankandhasamy , Nanda Sitansu Sekhar , Lee Jin-Hyung , Lee Jintae
Published: April 2020

Biofilm inhibition using nanoparticle-based drug carriers has emerged as a noninvasive strategy to eradicate microbial contaminants such as fungus Candida albicans. In this study, one-step adsorption strategy was utilized to conjugate alizarin (AZ) on graphene oxide (GO) and characterized by ultraviolet-visible spectroscopy (UV-Vis), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray powder diffraction (XRD), dynamic light-scattering (DLS), and transmission electron microscopy (TEM). Crystal violet assay was performed to evaluate the antibiofilm efficacy of GO-AZs against C. albicans. Different characterizations disclosed the loading of AZ onto GO. Interestingly, TEM images indicated the abundant loading of AZ by producing a unique inward rolling of GO-AZ sheets as compared to GO. When compared to the nontreatment, GO-AZ at 10 µg/mL significantly reduced biofilm formation to 96% almost equal to the amount of AZ (95%). It appears that the biofilm inhibition is due to the hyphal inhibition of C. albicans. The GO is an interesting nanocarrier for loading AZ and could be applied as a novel antibiofilm agent against various microorganisms including C. albicans.
ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 While ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition
Authors: Kurz Lukas , Miklyaeva Alissa , Skowron Margaretha A. , Overbeck Nina , Poschmann Gereon , Becker Teresa , Eul Katharina , Kurz Thomas , Schönberger Stefan , Calaminus Gabriele , Stühler Kai , Dykhuizen Emily , Albers Peter , Nettersheim Daniel
Published: April 2020

Germ cell tumors (GCTs) are the most common solid malignancies found in young men. Although they generally have high cure rates, metastases, resistance to cisplatin-based therapy, and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In a previous study, we identified downregulation of the chromatin-remodeling SWI/SNF complex member ARID1A as a key event in the mode of action of the histone deacetylase inhibitor romidepsin. Additionally, the loss-of-function mutations re-sensitize different tumor types to various drugs, like EZH2-, PARP-, HDAC-, HSP90- or ATR-inhibitors. Thus, ARID1A presents as a promising target for synthetic lethality and combination therapy. In this study, we deciphered the molecular function of ARID1A and screened for the potential of two pharmacological ARID1A inhibitors as a new therapeutic strategy to treat GCTs. By CRISPR/Cas9, we generated ARID1A-deficient GCT cells and demonstrate by mass spectrometry that ARID1A is putatively involved in regulating transcription, DNA repair and the epigenetic landscape via DNA Polymerase POLE and the DNA methyltransferase 1-associated protein DMAP1. Additionally, ARID1A/ARID1A deficiency or pharmacological inhibition increased the efficacy of romidepsin and considerably sensitized GCT cells, including cisplatin-resistant subclones, towards ATR inhibition. Thus, targeting ARID1A in combination with romidepsin and ATR inhibitors presents as a new putative option to treat GCTs.
Yeast Propagation Control: Low Frequency Electrochemical Impedance Spectroscopy as an Alternative for Cell Counting Chambers in Brewery Applications
Authors: Brunauer Georg Christoph , Spadiut Oliver , Gruber Alfred , Slouka Christoph
Published: April 2020

Electrochemical impedance spectroscopy is a powerful tool in life science for cell and pathogen detection, as well as for cell counting. The measurement principles and techniques using impedance spectroscopy are highly diverse. Differences can be found in used frequency range (β or α regime), analyzed quantities, like charge transfer resistance, dielectric permittivity of double layer capacitance and in off- or online usage. In recent contributions, applications of low-frequency impedance spectroscopy in the α regime were tested for determination of cell counts and metabolic burden in Escherichia coli and Saccharomyces cerevisiae. The established easy to use methods showed reasonable potential in the lab scale, especially for S. cerevisiae. However, until now, measurements for cell counts in food science are generally based on Thoma cell counting chambers. These microscopic cell counting methods decelerate an easy and quick prediction of yeast viability, as they are labor intensive and result in a time delayed response signal. In this contribution we tested our developed method using low frequency impedance spectroscopy locally at an industrial brewery propagation site and compared results to classic cell counting procedures.
Anisotropic Plastic Behavior in an Extruded Long-Period Ordered Structure Mg90Y6.5Ni3.5 (at.%) Alloy
Authors: Garces Gerardo , Barea Rafael , Stark Andreas , Schell Norbert
Published: April 2020

The Mg90Y6.5Ni3.5 alloy composed almost completely of the Long-Period-Stacking-Ordered (LPSO) phase has been prepared by casting and extrusion at high temperature. An elongated microstructure is obtained where the LPSO phase with 18R crystal structure is oriented with its basal plane parallel to the extrusion direction. Islands of α-magnesium are located between the LPSO grains. The mechanical properties of the alloy are highly anisotropic and depend on the stress sign as well as the relative orientation between the stress and the extrusion axes. The alloy is stronger when it is compressed along the extrusion direction. Under this configuration, the slip of  dislocations in the basal plane is highly limited. However, the activation of kinking induces an increase in the plastic deformation. In the transversal extrusion direction, some grains deform by the activation of basal slip. The difference in the yield stress between the different stress configurations decreases with the increase in the test temperature. The evolution of internal strains obtained during in-situ compressive experiments reveals that tensile twinning is not activated in the LPSO phase.
Synthesis of Carbon Onion and Its Application as a Porous Carrier for Amorphous Drug Delivery
Authors: Miriyala Nikhila , Kirby Daniel J. , Cumont Aude , Zhang Ruoying , Shi Baogui , Ouyang Defang , Ye Haitao
Published: April 2020

Given the great potential of porous carrier-based drug delivery for stabilising the amorphous form of drugs and enhancing dissolution profiles, this work is focussed on the synthesis and application of carbon onion or onion-like carbon (OLC) as a porous carrier for oral amorphous drug delivery, using paracetamol (PA) and ibuprofen (IBU) as model drugs. Annealing of nanodiamonds at 1100 °C produced OLC with a diamond core that exhibited low cytotoxicity on Caco-2 cells. Solution adsorption followed by centrifugation was used for drug loading and results indicated that the initial concentration of drug in the loading solution needs to be kept below 11.5% PA and 20.7% IBU to achieve complete amorphous loading. Also, no chemical interactions between the drug and OLC could be detected, indicating the safety of loading into OLC without changing the chemical nature of the drug. Drug release was complete in the presence of sodium dodecyl sulphate (SDS) and was faster compared to the pure crystalline drug, indicating the potential of OLC as an amorphous drug carrier.
Ultrasound for Neurogenic Thoracic Outlet Obstruction Remains Theoretical
Authors: Wilson Mitchell P. , Low Gavin , Katlariwala Prayash , Jacques Line , Jack Andrew S.
Published: April 2020

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Prioritized Uplink Resource Allocation in Smart Grid Backscatter Communication Networks via Deep Reinforcement Learning
Authors: Yang Zhixiang , Feng Lei , Chang Zhengwei , Lu Jizhao , Liu Rongke , Kadoch Michel , Cheriet Mohamed
Published: April 2020

With the rapid increase in the number of wireless sensor terminals in smart grids, backscattering has become a very promising green technology. By means of backscattering, wireless sensors can either reflect energy signals in the environment to exchange information with each other or capture the energy signals to recharge their batteries. However, the changing environment around wireless sensors, limited radio frequency and various service priorities in uplink communications bring great challenges in allocation resources. In this paper, we put forward a backscatter communication model based on business priority and cognitive network. In order to achieve optimal throughput of system, an asynchronous advantage actor-critic (A3C) algorithm is designed to tackle the problem of uplink resource allocation. The experimental results indicate that the presented scheme can significantly enhance overall system performance and ensure the business requirements of high-priority users.
Initial Responses in Growth, Production, and Regeneration following Selection Cuttings in Hardwood-Dominated Temperate Rainforests in Chile
Authors: Donoso Pablo J. , Ojeda Patricio F. , Schnabel Florian , Nyland Ralph D.
Published: April 2020

Hardwood-dominated forests in south-central Chile have shade-tolerant and mid-tolerant tree species capable of regenerating and growing well in partial shade. To test the potential for using an uneven-aged silviculture in these forests, we established single-tree selection treatments at two mid-elevation sites within the Evergreen forest type in the Coastal range (Llancahue and Los Riscos, 40–42° S Lat). They had an average initial basal area of 70–80 m2 ha−1. In each stand, we established four 2000 m2 plots with a residual basal area of ~40 m2 ha−1, and four with a residual basal area of ~60 m2 ha−1. We planned for a maximum residual diameter of 80 cm, but needed to leave 20%–25% of the residual basal area in larger trees due to their great abundance in these old-growth forests. We re-measured these plots 5–6 years after the cuttings. We used mixed-effects models to evaluate the periodic annual increment (pai) in diameter and the abundance of tree regeneration, and linear models to evaluate ingrowth and changes in the basal area and volume. At Llancahue, the diameter pai of individual trees was significantly greater in the treatment with lower residual densities, especially for mid-tolerant species in lower diameter classes (5–20 cm). At both sites, the pai in the stand basal area and volume was greater in the more heavily stocked treatment, but differences were significant only at Llancahue. Regeneration was dominated by shade-tolerant species at both sites but was more abundant and more diverse at Llancahue. Taller tree regeneration (50–<200 cm) significantly increased after the cuttings at both sites, while small regeneration (5–<50 cm) overall remained at pre-cut levels. This pattern was similar for mid- and shade-tolerant species. However, we found no differences in regeneration responses between the lower and higher levels of the residual basal area. Sapling densities did not differ at both sites for shade-tolerant species, but for mid-tolerant species these were more abundant at Los Riscos. While both sites had many similar trends after implementing selection cuts (a greater individual growth in the treatment with lower basal areas but a higher stand-level growth in the treatment with a high basal area, more abundant regeneration of shade-tolerant species, etc.), they illustrate a differential potential for implementing uneven-aged silviculture, especially due to site-species interactions. These results are a first step towards evaluating the prospects for selection cuttings in these experiments and elsewhere in Valdivian temperate rainforests.
Spatial Landslide Risk Assessment at Phuentsholing, Bhutan
Authors: Dikshit Abhirup , Sarkar Raju , Pradhan Biswajeet , Acharya Saroj , Alamri Abdullah M.
Published: April 2020

Landslides are one of the most destructive and most recurring natural calamities in the Himalayan region. Their occurrence leads to immense damage to infrastructure and loss of land, human lives, and livestock. One of the most affected regions is the Bhutan Himalayas, where the majority of the landslides are rainfall-induced. The present study aims to determine the hazard and risk associated with rainfall-induced landslides for the Phuentsholing region located in the southwestern part of the Bhutan Himalayas. The work involves developing a landslide risk map using hazard and vulnerability maps utilizing landslide records from 2004 to 2014. The landslide hazard map was generated by determining spatial and temporal probabilities for the study region. The spatial probability was computed by analyzing the landslide contributing factors like geology, slope, elevation, rainfall, and vegetation based on comprehensive field study and expertise about the area. The contributing factors were divided into various classes and the percentage of landslide occurrence under each class was calculated to understand its contributing significance. Thereafter, a weighted linear combination approach was used in a GIS environment to develop the spatial probability map which was multiplied with temporal probabilities based on regional rainfall thresholds already determined for the region. Consequently, vulnerability assessment was conducted using key elements at risk (population, land use/land cover, proximity to road, proximity to stream) and the weights were provided based on expert judgment and comprehensive field study. Finally, risk was determined and the various regions in the study area were categorized as high, medium, and low risk. Such a study is necessary for low-economic countries like Bhutan which suffers from unavailability of extensive data and research. The study is conducted for a specific region but can be extended to other areas around the investigated area. The tool can serve as an indicator for the civil authorities to analyze the risk posed by landslides due to the rapid infrastructure development in the region.
The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE)
Authors: Pheby Derek F.H. , Araja Diana , Berkis Uldis , Brenna Elenka , Cullinan John , de Korwin Jean-Dominique , Gitto Lara , Hughes Dyfrig A , Hunter Rachael M , Trepel Dominic , Wang-Steverding Xia
Published: April 2020

We have developed a Europe-wide approach to investigating the economic impact of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), facilitating acquisition of information on the economic burden of ME/CFS, and international comparisons of economic costs between countries. The economic burden of ME/CFS in Europe appears large, with productivity losses most significant, giving scope for substantial savings through effective prevention and treatment. However, economic studies of ME/CFS, including cost-of-illness analyses and economic evaluations of interventions, are problematic due to different, arbitrary case definitions, and unwillingness of doctors to diagnose it. We therefore lack accurate incidence and prevalence data, with no obvious way to estimate costs incurred by undiagnosed patients. Other problems include, as for other conditions, difficulties estimating direct and indirect costs incurred by healthcare systems, patients and families, and heterogeneous healthcare systems and patterns of economic development across countries. We have made recommendations, including use of the Fukuda (CDC-1994) case definition and Canadian Consensus Criteria (CCC), a pan-European common symptom checklist, and implementation of prevalence-based cost-of-illness studies in different countries using an agreed data list. We recommend using purchasing power parities (PPP) to facilitate international comparisons, and EuroQol-5D as a generic measure of health status and multi-attribute utility instrument to inform future economic evaluations in ME/CFS.