bluuebunny/crossref_metadata_2025 huggingface dataset:
Da Maestri di Strada a CoroNauti: l'impatto della pandemia sulla comunità educante di una periferia metropolitana
Authors: Carillo Filomena , Fenizia Elisabetta , Parrello Santa
Published: November 2022

Maestri di Strada (MdS) è un'associazione non profit che lavora nella periferia est di Na-poli per contrastare dispersione scolastica ed esclusione sociale attraverso interventi socioeducativi complessi. La pandemia da COVID-19 ha investito all'improvviso tutte le attività di MdS, spingendo ad utilizzare la tecnologia come risorsa per affrontare il problema dell'isolamento. A marzo 2020 è nato il Progetto CoroNauti, con l'obiettivo di supportare anche a distanza il senso di comunità per fronteggiare in modo resiliente il trauma, limitando gli effetti del divario dovuto alle povertà educative del territorio. Si è costituita così una comunità virtuale di pratiche di tipo riflessivo, che ha sostenuto in modo nuovo i processi educativi già avviati. L'intervento si è sviluppato con tutti gli attori della comunità locale educante, giovani, scuole, famiglie e ha prodotto diversi cambiamenti.
PRODUCTIVITY AND ADAPTABILITY OF BRIGHT DIFFERENT GENOTYPES UNDER THE INFLUENCE OF CLIMATE FACTORS
Authors: Korkh Korkh I. , Boyko Natalia , Pomitun Ivan , Rudenko Evgen , Kryvoruchko Yrij
Published: November 2022

Modern problems of sheep breeding emphasize the urgent need for thorough research aimed at further improving the existing breeds of sheep, breed groups and high-yielding types of meat and meat-wool areas of productivity in the face of climate change. An equally important approach in the selection of sheep breeds is to identify the relationship between internal indicators of their body and signs of productivity. This makes it possible to effectively use the biological reserves of sheep in the direction of increasing meat and wool productivity, as well as to obtain new data on the formation of the adaptability of animals of different genotypes in ontogenesis. Given this, the research aimed to reveal the patterns of influence of climatic factors on the productivity and adaptability of brightly different genotypes with traditional technology of sheep production.
The experimental work was carried out in the production conditions of the breeding plant of the State Enterprise "Gontarivka" IT NAAS Chuguiv district of Kharkiv region, the department of selection and technological research in small livestock and horse breeding of the Institute of Animal Husbandry NAAS. It was found that the cultivation of bright in the conditions of pasture-camp content, compared with the stall-camp, despite the negative impact of outdoor air temperature, contributes to a more pronounced normalizing effect on the intensity of their growth while increasing the average daily gain by 42.0 g or 35.2 % and improving the reproductive function, due to the ability to arrive earlier than others in the hunt. It is proved that seasonal fluctuations of climatic conditions cause an increase in body temperature, respiratory rate and pulse, a gradual increase in temperature from the lower to the upper zones of the staple in runes and cause thermal differences in different topographic areas of the body surface.
DEFINITION OF ORGANIZATIONAL MECHANISMS OF LIVESTOCK PRODUCTION ON THE PRINCIPLES OF INNOVATIVE BIOECONOMICS
Authors: Marchenko V. , Trishin Aleksei , Chigrinov E. I. , Piskun V. , Antonenko Sergey , Tkachev A.
Published: November 2022

The constructional mechanisms of interrelations related to separate systems belonging to the production of livestock products on the principles of bioeconomy were substantiated, systematized and, accordingly, schematically defined. Monitoring and generalization of the specifics of the existing logistics systems in the production of livestock products on the example of farms in the Kharkiv region and research farms of the NAAS network and evaluating the features of their operation. It is established that the increase in production capacity causes a corresponding increase in technological equipment, which leads to more efficient use of labor, energy and other material resources.
The analysis of the grouping data confirmed the fact and recorded a clear trend of increasing the productivity of cows while reducing the cost of 1 quintal of milk with increasing the production capacity of enterprises, including cows. Thus, the average milking for a cow increased from 4282 kg in the first group to 8493 kg in the fifth, with a corresponding increase in the average annual number of cows from 152 to 1216 heads. At the same time, the cost of 1 quintal of milk decreased by 10%. The low rate of reduction in the cost of milk compared to an increase in productivity of cows in 2 times due to an increase, above all, variable costs in increasing the capacity of enterprises. It is established that there are three main mechanisms of organization of livestock production on the principles of innovative bioeconomy: situational response, situational reform, and implementation of systemic reforms. The calculations made it possible to assess the structure of resource costs by species and draw conclusions about the functioning of livestock production mechanisms depending on the type of enterprise, and the effectiveness of management actions - on the performance of gross production, its cost and sales revenue.
HISTORICAL PREREQUISITES AND TECHNOLOGICAL APPROACHES CRYOCORPRESERATION OF AGRICULTURAL SPERM
Authors: Sushko Alexey , Savelieva Marina , Martinyk Irina , Yeletska Larysa
Published: November 2022

An overview of domestic and foreign literature sources, as well as data from published own research on cryopreservation of animal sperm. The main historical stages of the creation of methods and technologies for deep freezing of sperm are given. The effectiveness of germ cell freezing depending on the applied endocellular and exocellular cryoprotectants is shown. Own experimental data on the effect of combinations of glycerol with substances of the amide group in cryophylactic media on the state of plasma membranes of sperm after deconservation are presented. Based on the literature data and published results of our experiments, the influence of cooling regimes of animal sperm on its physiological parameters after freezing thawing is shown. Data on the influence of protocols on deconservation of sperm of germs on the state of germ cells are given.
As a result of long-term work of scientists, fundamental knowledge has been gained, created cryobiotechnologies that allow storing animal sperm in vitro in a deep-frozen state for almost an unlimited period.
THE GENE POOL OF THE TRAKEHNER HORSE BREED OF DOMESTIC SELECTION
Authors: Zaderikhina Elena , Rossokha Volodimir , Tur G. , Oliinychenko Yelyzaveta , Brovko O.
Published: November 2022

The article outlines the data on the study of the specifics of the gene pool of the horses of the Trakehner breed of domestic selection as a whole (n = 236), and leading tribal business entities and the private sector.
Immunogenetic differences are identified and a comparative characteristic of horses of farms behind frequencies and spectrum of alleles of genetic blood group systems has been carried out.
The population of the Trakehner breed of horses of domestic selection owns a peculiar immunogenetic profile in the context of the tribal business entities and the private sector, owns certain specificity and variability, which is associated with both breed differences and different breeding methods in our country.
In stallions (n=89), the frequency of the Dcegm allele (q=0,034), Dd (q=0.124), Ddg (q=0.079), Ddk (q=0.337) is significantly a significant temple, and Dbcm alleles (q=0.129), Dcgm (q=0.185), Dde (q=0.112) significantly low than the Dcegm mares (n=147) (q=0.014), Dd (q=0.102), Ddg (q=0.065), Ddk (q=0.320) and Dbcm (q=0.146), Dcgm (q=0.207), Dde (q=0.139) - respectively. Also, the stallions had no allele Dad.
The Trakehner horse breed of domestic selection has the highest concentration in the frequencies of alleles DDK (q=0.326), and somewhat high in the frequencies of Dcgm alleles (q=0.199), Dbcm (q=0.139) and Dde (q=0.129). The allele Dad (q=0,004) is extremely rare.
The most common among all the populations of the Trakehner horse breed studied by us according to the D-system are the alleles Dcgm, Ddk. They were observed on all farms of certified horses of this breed. The highest frequencies of the Dcgm allele in the farms: OOO "Borzhava Plus" (q=0.35), OOO "Kleinoda" (q=0.33), OOO "KSK"Prodani koni"(q=0.31), SOOO AF "Zorya"(q=0.21) and private owners (q=0.22). The frequency of the Ddk allele is the highest in the farms of OOO "Borzhava Plus" (q=0.65), the horse farm "Vinnichina" (q=0.50), OOO "Kleinoda" (q=0.50), OOO "Russia" (q=0.50).
In the same system, the Dcegm allele was observed in 4 farms: SOOO AF "Zorya" (q=0.03), the equestrian plant "Vinnichina" (q=0.07), in small farms (q=0.03) and frequent sectors (q=0.05).
The highest number of homozygous horses of the Trakehner breed in farms: GP "Pivdenkonetsenter" (N = 5), OOO "Russia" (n = 5) and in small farms (n = 8).
Plurinational state and ecological conscience in Bolivia: The case of the 2019 forest fires
Authors: Barié Cletus Gregor , Zuazo Moira
Published: November 2022

In 2019, Bolivia suffered one of the worst forest fires in its history. The rapid advance of the flames provoked reactions in defence of the environment hitherto unknown in Bolivian society. Encouraged by a peaceful march of lowland indigenous communities, a broad spectrum of social actors expressed their indignation at the destruction of the forests and demanded more governmental action. The spontaneous emergence of ecological awareness during the fire crisis allows reflection on the progress in constructing the symbolic state, a state in the “heads” and imaginaries of citizens (Bourdieu, 2014). Social demands during the crisis reflect new expectations placed on a plurinational state respectful of the rights of nature. By ignoring the ongoing ecological catastrophe, the government placed itself at the margin of an emerging symbolic order to which it had previously contributed and of which it is a product. Resumen: Estado plurinacional y conciencia ecológica en Bolivia: El caso de los incendios forestales de 2019En 2019, Bolivia sufrió uno de los peores incendios forestales de su historia. El rápido avance de las llamas provocó reacciones en defensa del medio ambiente hasta ahora desconocidas en la sociedad boliviana. Alentados por una marcha pacífica de las comunidades indígenas de las tierras bajas, un amplio espectro de actores sociales expresó su indignación por la destrucción de los bosques y exigió una mayor acción gubernamental. La emergencia espontánea de la conciencia ecológica durante la crisis de los incendios permite reflexionar sobre el avance en la construcción del estado simbólico, un estado en las “cabezas” e imaginarios de los ciudadanos (Bourdieu, 2014). Las demandas sociales durante la crisis reflejan las nuevas expectativas puestas en un estado plurinacional respetuoso con los derechos de la naturaleza. Al ignorar la catástrofe ecológica en curso, el gobierno se situó al margen de un orden simbólico emergente al que había contribuido previamente y del que es un producto.
Mentioning of the General After the Special in the Holy Quran and its Rhetorical Secrets: A Rhetorical Study
Authors: Muhammed Roqaya Ibrahim Al-Haaj Badri
Published: November 2022

Verbiage is considered one of the distinct rhetorical methods, Which we must take into account in our speech and writing, There are many types of verbiage, One of the most important is to mention the public after the private, The public mentioned after the private, Where they play an important role in directing the Qur’anic discourse, its significance and explanation, Characteristics of the rhetorical miracle of the Holy Quran, And they strengthen the meanings and confirm them. Verbiage does not have the main purpose of prolonging, but it comes to a benefit that the place requires and for rhetorical purposes understood from the context and evidence of conditions. In this research, I will work on highlighting this rhetorical aesthetics associated with the detailed book and the perfect model in our Arabic rhetoric.
LEVEL OF PARTICIPATION IN GROUP OF FARMER MEMBERS IN THE GOGO RAWA RICE PLANTING PROGRAM AT PEMULUTAN ULU VILLAGE, OGAN ILIR REGENCY
Authors: Azmee Nur , Umikalsum R.A. , Anggraini Anggraini
Published: November 2022

This study aims to analyze the response, level of participation and factors that influence the level of participation of members of farmer groups who receive rice seed assistance in Pemulutan Ulu Village, Ogan Ilir Regency. The method used in this research is a survey method with a simple random sampling method from 306 farmers taken as much as 10% of the sample. Data analysis was performed by means of tabulation and multiple linear regression which was then explained descriptively. The results showed that the response of farmer group members to the implementation of the upland swamp rice planting program was in the medium category with a score of 53.33. The level of farmer participation is also in the moderate category with a score of 44.5. The utilization rate of upland rice assistance reaches 100%, but in terms of plant maintenance it is still low. Factors that significantly influence the level of participation are age, education, farming experience and number of dependents. While the factors that have no effect are land area, extension socialization and motivation.
التأصيل الشرعي في معالجة كوفيد- 19 باللقاحات
Authors: Hoque Mesbahul , Abdul Kadir Kauthar , Abdul Rab Muneer Ali , Abdul Halim Amran , Mohamed Yuslina
Published: November 2022

اختلف بعض المسلمين في هذه الأيام في أخذ اللقاحات المضادة للفيروس كورونا ( كوفيد-19) على أساس أن منشأ هذه اللقاحات بلاد غير إسلامية وكذلك عدم توافر المعلومات الكافيىة لمكونات هذه اللقاحات. ونظرًا لأهمّيّة الوقاية من هذا الوباء، جاء هذا البحث ليبيّن حكم الشّرع في أخذ هذه اللقاحات والاستفادة منها لعلاج المرضى المصابين بهذا الوباء، ولسلامة الأصحاء من الإصابة، وسيسلك الباحث المنهج الاستقرائي والمنهج التّحليلي، اللّذين يتمثّلان في استقراء وتتبّع أيات القرآن وأحاديث الرسول وأقوال الفقهاء والأصوليّين وأدلّتهم في هذا الشأن، وتحليلها ومناقشتها، ثمّ استنباط الحكم الشّرعي لها، بما يتوافق مع روح الشّريعة الإسلاميّة ومقاصدها.كما سيعرّج إلى أقوال وآراء الأطبّاء المتخصّصين في هذا المجال من مراجعهم أو المواقع المعتمدة في الطّبّ. وقد خلّص البحث إلى نتائج عديدة، من أهمّها أن التداوي سنّة نبوية مؤكدة، لا تناقض بينها وبين مبدأ التوكل على الله والإيمان بالقضاء والقدر، كما أن الإسلام لا يحرم الاستفادة من الأدوية أو اللقاحات على أساس أنها مصطنعة في غير بلاد المسلمين إذا لم تكن هناك أدلة قاطعة على مكوّنات محرمّة أو نجسة، كما أن الإسلام يجيز الأدوية التي تحتوي على مكونات محرّمة أو نجسة عند الضرورة بقدر الضرورة.
MAPPING HALAL COSMETICS RESEARCH: A BIBLIOMETRIC ANALYSIS
Authors: Zakaria Zalina , Ramli Siti Qhairunissa , Mohd Shoid Nur Syamimi Zawani , Sulaiman Ainin
Published: November 2022

This study conducted a bibliometric analysis of research related to halal cosmetics. Data from 2006 to 2020 related to halal cosmetics were extracted from the Scopus database, providing a sample of 104 documents. The documents were then examined using the bibliographic network visualization instrument VOS viewer and R for text mining and the findings were presented in the form of a conceptual structure map and word clouds. We identified the most productive authors, journals, institutions, and countries. The results showed that Malaysia and Indonesia are the overall leaders in publications. The Journal of Islamic Marketing and International Journal of Supply Chain are the most influential journals in the field. These findings will provide scholars a comprehension of the halal cosmetics field and act as a guide for future research.
MUSLIM CONSUMERS’ PERCEPTIONS ON COUNTERFEIT COSMETICS
Authors: Nor Zaidi Farah Lynn Amira , Jamaluddin Mohd Aizat , Tukiman Nur Azira
Published: November 2022

In conjunction with the rise of the Muslim population and beauty awareness, the halal cosmetic industry is expected to grow significantly. This growth serves as an opportunity for the cosmetic industry in Malaysia to bring out a lot of new cosmetic products into the industry. However, it can lead to strengthen the market competition which then resulting in the emergence of counterfeit and unlicensed cosmetic and beauty products into the local market. Despite the growing potential of halal cosmetic industry, consumers are not being exposed sufficiently to the importance of halalan tayyiban in a cosmetic product. This study will analyze the influence of religiosity, brand consciousness and demographic background towards perception of Muslim consumers on counterfeit cosmetic products. Data for this study are extracted from existing literatures in the research area of Halal cosmetic industry in local and outside Malaysia. This study will give the opportunity for future researchers to expand the area of research of halal cosmetics and will be essential for future developments in the halal cosmetics industry itself.
IDENTIFICATION OF THE DEAD UNDER ISLAMIC LAW AND INTERNATIONAL HUMANITARIAN LAW: AN ANALYSIS
Authors: Lefolle Julie
Published: November 2022

The Islamic world has been confronted with many challenges in recent history such as situations of violence, armed conflict, global pandemic and natural disasters. One of the many catastrophic consequences of such events are the findings of numerous unidentified bodies. Is the identification of dead bodies a legal obligation under both Islamic law and International Humanitarian Law (IHL) or is it merely a moral duty to help grieving family members? The purpose of this research is first, to give an overview of the Islamic law principles governing the identification of the dead. Second, to illustrate those principles with current examples of humanitarian challenges in the Islamic world. Third, to compare those Islamic law principles to IHL rules applicable in armed conflicts and demonstrate that both IHL and Islamic Law aim to end the suffering of families of missing persons. This research demonstrates that both Islamic law and IHL have rules which aim to protect the dignity and respect of dead bodies and they complement each other in contexts of armed conflicts or other situations of violence. By identifying the similarities and complementarities of both bodies of law this research paper contributes to expanding the legal framework which can be promoted and used by humanitarians to protect families of the dead and end their suffering by obtaining information on the fate and whereabouts of their loved ones. In cases of mismanagement of the dead, in Muslim contexts, resulting in the burial of unidentified bodies, humanitarians should discuss with religious authorities and raise the various principles of Islamic law described in this paper such as the prohibition of collective graves and cremation and the exceptions made in practice for the exhumation of dead bodies. International scholars should also underscore the importance of storing information on the deceased before burying them and of participating in the development of forensic science in Islamic countries.
„leiðin er innávið og uppímóti“. Fjórða bylgja femínismans og íslenskar kvennabókmenntir
Authors: Óskarsdóttir Ásdís Helga
Published: November 2022

Femínískri umræðu hefur vaxið fiskur um hrygg á samfélagsmiðlum síðustu ár. Hér á landi hefur aðdragandi fjórðu bylgju femínismans verið býsna öflugur og aðgerðir undir svokölluðum myllumerkjum (e. hashtag) vakið athygli og jafnvel leitt til falls ríkisstjórnar og alþingiskosninga eins og umræðan undir #Höfumhátt sýndi árið 2017. Femínísk umræða síðustu ára hefur að miklu leyti hverfst um kynferðisofbeldi, sem endurspeglast í aðgerðum á borð við framangreinda #Höfumhátt en jafnframt í hinni alþjóðlegu #MeToo-hreyfingu og Brjóstabyltingunni (e. free the nipple). Kvenlíkaminn er þannig óhjákvæmilega miðlægur í þessum áherslum og aðgerðum. Markmið þessarar greinar er að fjalla um aðdraganda fjórðu bylgju femínismans í íslensku samfélagi og bókmenntir ungra, íslenskra kvenna sem innlegg í baráttuna og samband þeirra við kvenlíkamann. Í stuttu máli endurspeglar þetta samband ýmiskonar togstreitu sem rekja má til fegurðar- og hegðunarkrafna sem fjölmiðlar eiga stóran þátt í að magna upp og þeirrar ógnar sem stafar af ofbeldi af hálfu karlmanna. Skáldkonurnar nota líkamlegt myndmál með margvíslegum hætti og svar þeirra birtist meðal annars í ákalli um uppreisn og kvennasamstöðu þvert á kynslóðir.
„Hver vill verða hrein mey aftur?“ Kynfrelsi og klámvæðing í póstfemínískri umræðu
Authors: Valdimarsdóttir Alda Björk
Published: November 2022

Í greininni er farið yfir helstu kenningar í póstfemínískum fræðum og leitast við að útskýra þær samræður sem fulltrúar slíkra hugmynda telja sig eiga í við fyrri kynslóðir og konur um aldamótin síðustu. Leitast er við að draga fram hvernig póstfemínisminn er hluti af þriðju bylgju femínisma og hvernig hann sem slíkur hefur áhrif á fjórðu bylgjuna þrátt fyrir að hugmyndaheimur hans geti hljómað annarlega í ljósi aðgerðarstefnu metoo bylgjunnar. Jafnframt er dregið fram hvernig eitt af einkennum femínismans sé samræða og mótþrói við kynslóðina sem kemur á undan. Farið er sérstaklega í viðhorf stefnunnar til kynfrelsis kvenna, klámvæðing í poppmenningu er tekin fyrir og uppgjörið við Playboy kónginn Hugh Hefner. Þá er þáttaröðin Sex and the City greind með hliðsjón af kynvitund, kyngervi og viðhorfum til einhleypu konunnar um síðustu aldamót. Einnig er framhaldsþáttaröðin And Just Like That … skoðuð með það í huga að bera saman ólík efnistök þáttanna á daglegu lífi vinkvennanna á nýjum tímum.
Localization of the spectra of dual frames multipliers
Authors: Corso Rosario
Published: November 2022

This paper concerns dual frames multipliers, i.e. operators in Hilbert spaces consisting of analysis, multiplication and synthesis processes, where the analysis and the synthesis are made by two dual frames, respectively. The goal of the paper is to give some results about the localization of the spectra of dual frames multipliers, i.e. to identify regions of the complex plane containing the spectra using some information about the frames and the symbols.
“Digital virtues”? Aristotelian Leadership in the Fourth Industrial Revolution
Authors: Panagiotis Tzavaras  , Stelios Spyridon
Published: November 2022

Aristotelian leadership in corporations and organizations and the virtues associated with it has been extensively studied. Today, due to the pandemic but mainly because of Information Communication Technologies (ICT) and the Fourth Industrial Revolution, there is an increase in online communication within corporate organizations (via emails, teleconferencing, etc.). In this new context, managers, CEOs and company leaders are developing digital behaviors. Online and electronic communication has largely replaced in person and a leader or e-leader should cultivate and use her virtues within a new digital environment. In this context, can we refer to emerging “digital virtues” or is the technological factor too “weak” to disturb the nature of these character traits? In order to address this question, this paper investigates four Aristotelian virtues that lie at the heart of an ethical corporate leader, i.e. “prudence/practical wisdom”, “fortitude” (courage), “temperance”, and “justice”. The findings will determine whether changing the means of communication affects the way in which a leader should develop these virtues.
A importância da correta indicação da cirurgia ortognática, reabilitando fonética e harmonia facial
Authors: Brito Tayanne Antunes , Andrade Fernando Silva , Yamashita Ricardo Kiyoshi , Klug Rufino José
Published: November 2022

A aparência facial é uma característica importante tanto no contexto evolutivo quanto de relação interpessoal, modificações que ocorrem no desenvolvimento da estrutura facial podem ocasionar desarmonia anatômica, acarretando adversidades fisiológicas e estética. A cirurgia ortognática é um conjunto de técnicas de osteotomias executadas no sistema mastigatório visando corrigir as discrepâncias e restabelecendo o equilíbrio crânio e face, tratando as alterações dentofaciais promovendo diversos resultados positivos como melhora na autoestima, função mastigatório, respiração e fonação. Nesse contexto, objetivou-se discorrer por meio de revisão de literatura narrativa a respeito da importância da correta indicação da cirurgia ortognática, promovendo uma melhor qualidade de vida aos pacientes, melhorando fonética e proporcionando à harmonia facial. A pesquisa inclui uma revisão narrativa da literatura para sintetizar evidências do tema proposto em um artigo, tendo como base trabalhos anteriores referentes ao tema, de forma a facilitar a visualização dos resultados. A base de dados foi pesquisada no Google acadêmico, SciELO, Periódicos Capes. Por meio do levantamento dos trabalhos acadêmicos, verificou-se que a cirurgia ortognática visa reabilitar pacientes com discrepâncias dento esquelético, restabelecendo o equilibro da face e crânio, onde é imprescindível a ação de outros profissionais da saúde em prol do desenvolvimento adequado do paciente. A correta indicação da cirurgia tornará possível o sucesso do tratamento, onde a integração dos dados colhidos na anamnese se faz necessário para um bom planejamento.
Meningkatkan Semangat Nasionalisme Melalui Pendidikan Pancasila pada Masa Pandemi COVID-19
Authors: Iswara Yessy Tri , Ginting Arwanto Harimas
Published: November 2022

Pendidikan Pancasila tidak cukup dilaksanakan melalui pembelajaran umum di sekolah-sekolah. Perlu model lain dengan kegiatan sosialisasi yang di dalamnya ada pemaparan materi, kuis, dan diskusi dalam membangun pemahaman siswa tentang nasionalisme dengan pendidikan Pancasila. Kegiatan ini bertujuan untuk meningkatkan rasa nasionalisme di kalangan siswa. Metode dalam kegiatan pengabdian masyarakat ini dengan sosialisasi dengan diskusi ilmiah dan menggunakan aplikasi Quizizz. Dari kegiatan ditemukan. Kegiatan ini mendapat antusias dari para siswa terlebih dalam kegiatan diskusi dan penggunaan aplikasi. Ada semangat baru untuk mengetahui dengan keinginan mencapai skor dalam kegiatan diskusi dan lomba kecepatan dan ketepatan menemukan jawaban yang berkaitan dengan penguatan semangat nasionalisme. Untuk itu perlu dilakukan kegiatan lain yang dapat menumbuhkan nasionalisme dengan menggunakan kemajuan teknologi informasi yang saat ini sudah menjadi bagian dari kehidupan siswa pada umumnya terlebih pada saat pandemi COVID-19.
Partisan Asymmetries in Earmark Representation
Authors: Casella Chris , Fagan E.J. , Theriault Sean
Published: November 2022

This paper examines the variation in earmarking behavior between Republicans and Democrats in the U.S. House of Representatives. After a ten-year moratorium, Congress brought back earmarks to the appropriations process in 2021 enabling members to request small grants for community programs in their districts. As part of a reform designed to limit corruption and wasteful spending, members had to submit written justifications for the grants, which provide insight into how members of Congress view their role as representatives. In performing a content analysis on 3,007 earmark justifications, we find that Democrats are more likely to justify their spending by noting its benefits to specific social groups in their party coalition, while Republicans rarely do so. Democrats are more likely to request grants on their core partisan priorities, while Republicans tend to focus on large local infrastructure projects that are seemingly unrelated to their national priorities.
Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis
Authors: Cortes Lizette M. , Brodsky David , Chen Celine , Pridgen Tiffany , Odle Jack , Snider Douglas B. , Cruse Glenn , Putikova Arina , Masuda Mia Y. , Doyle Alfred D. , Wright Benjamin L. , Dawson Harry D. , Blikslager Anthony , Dellon Evan S. , Laster Scott M. , Käser Tobias
Published: November 2022

Eosinophilic esophagitis (EoE) is a chronic allergy-mediated condition with an increasing incidence in both children and adults. Despite EoE's strong impact on human health and welfare, there is a large unmet need for treatments with only one recently FDA-approved medication for EoE. The goal of this study was to establish swine as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics. We recently showed that after intraperitoneal sensitization and oral challenge with the food allergen hen egg white protein (HEWP), swine develop esophageal eosinophilia—a hallmark of human EoE. Herein, we used a similar sensitization and challenge treatment and evaluated immunological and pathological markers associated with human EoE. Our data demonstrate that the incorporated sensitization and challenge treatment induces (i) a systemic T-helper 2 and IgE response, (ii) a local expression of eotaxin-1 and other allergy-related immune markers, (iii) esophageal eosinophilia (>15 eosinophils/0.24 mm2), and (iv) esophageal endoscopic findings including linear furrows and white exudates. Thereby, we demonstrate that our sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EoE. This swine model for EoE represents a novel relevant large animal model that can drive translational biomedical research to develop urgently needed treatment strategies for EoE.
A comparison of online and live training of livestock farmers for an on-farm self-assessment of animal welfare
Authors: Michaelis Sarina , Schubbert Antje , Gieseke Daniel , Cimer Kornel , Zapf Rita , Lühken Sally , March Solveig , Brinkmann Jan , Schultheiß Ute , Knierim Ute
Published: November 2022

One approach to strengthening the involvement of farmers or stockpersons in the evaluation and improvement of animal welfare is the implementation of an on-farm self-assessment. A valid comparison of the results with reference values, between or within farms, requires that training of the farmers and reliability testing have taken place. We investigated two different training methods (online vs. live) with a total of 146 livestock farmers from farms with dairy cows and calves, beef cattle, sows and suckling piglets, weaners and fattening pigs, laying hens, broiler chickens, and turkeys from all over Germany. Online tests were conducted by assessing photos/videos of each indicator of the assessment scheme to estimate the inter-rater reliability (prevalence-adjusted and bias-adjusted kappa, PABAK). The farmers were requested to provide information on their professional background and rate their motivation to participate in the training and their subjective training success, meaning their confidence in assessing each indicator later on-farm. They evaluated the feasibility of the training and its impact on their views and attitudes. In general, farmers achieved at least substantial inter-rater reliability (PABAK ≥ 0.61) in 86.8% of all initial tests; 13.4% of the tests were repeated once or more times, resulting in a significant improvement of the agreement, with 90.9% of the tests reaching a PABAK ≥ 0.61. However, reliability was higher for indicators with a lower number of score levels. The subjective evaluation of training success was, on average, positive (score = 74.8 out of 100). No effects of the training method or the farmers’ professional background on the inter-rater reliability or the subjective training success were detected. Furthermore, for both methods, farmers moderately agreed that the training had sharpened their views on the animals, encouraged them to implement the assessment on their farm, and made it clear that self-assessment supports animal management. Although the reported costs and time investment for the online training were significantly lower, the effort required for both methods and the ease of integration into the workflow were ranked as similarly acceptable. Overall, both training methods appear feasible for the training of farmers/stockpersons on the assessment of animal-based indicators.
Electrochemical corrosion resistance of aluminum alloy 6101 with cerium-based coatings in an alkaline environment
Authors: Khan Ahsan Riaz , Zhang Hai-Jun , Jun Zhang , Eldin Sayed M , Alsaiari Norah Saleem , Katubi Khadijah Mohammedsaleh
Published: November 2022

Chromium-free materials as eco-friendly coatings with higher corrosion resistance are crucial in various industrial processes. Herein, we report the deposition of cerium-based conversion, a chromium-free, eco-friendly chemical conversion coating for aluminum alloy 6101, by the dip coating method. Immersion in cerium salt precursors assisted with hydrogen peroxide was performed for the deposition of cerium-based conversion coatings on aluminum alloy 6101 at different bathing temperatures. The electrochemical corrosion behavior was assessed in an alkaline solution of sodium hydroxide (pH 11), including mass loss measurements, free corrosion risk, polarization, and electrochemical impedance spectroscopy. X-ray diffraction and photoelectron spectroscopy analysis showed that the coatings were composed of Ce (III) and Ce (IV) oxides. Surface modifications and surface degradation of the coating and substrate after immersion in corrosive media were analyzed by scanning electron microscopy. Additionally, energy dispersive scanning analysis demonstrated the elemental composition before and after corrosion of the cerium salt conversion-based coating. The results demonstrated that selectively deposited cerium-based conversion coatings improved the corrosion resistance by up to 96% in a strong corrosive alkaline media.
Photocatalytic degradation of tetracycline hydrochloride with g-C3N4/Ag/AgBr composites
Authors: Song Jiahe , Zhao Kun , Yin Xiangbin , Liu Ying , Khan Iltaf , Liu Shu-Yuan
Published: November 2022

Graphite carbon nitride (g-C3N4), as a polymer semiconductor photocatalyst, is widely used in the treatment of photocatalytic environmental pollution. In this work, a Z-scheme g-C3N4/Ag/AgBr heterojunction photocatalyst was prepared based on the preparation of a g-C3N4-based heterojunction via in-situ loading through photoreduction method. The g-C3N4/Ag/AgBr composite showed an excellent photocatalytic performance in the degradation of tetracycline hydrochloride pollutants. Among the prepared samples, g-C3N4/Ag/AgBr-8% showed the best photocatalytic ability for the degradation of tetracycline hydrochloride, whose photocatalytic degradation kinetic constant was 0.02764 min−1, which was 9.8 times that of g-C3N4, 2.4 times that of AgBr, and 1.9 times that of Ag/AgBr. In the photocatalytic process, •O2– and •OH are main active oxygen species involved in the degradation of organic pollutants. The photocatalytic mechanism of g-C3N4/Ag/AgBr is mainly through the formation of Z-scheme heterojunctions, which not only effectively improves the separation efficiency of photogenerated electron-hole pairs, but also maintains the oxidation and reduction capability of AgBr and g-C3N4, respectively.
MD simulations explain the excess molar enthalpies in pseudo-binary mixtures of a choline chloride-based deep eutectic solvent with water or methanol
Authors: Engelbrecht Leon de Villiers , Ji Xiaoyan , Carbonaro Carlo Maria , Laaksonen Aatto , Mocci Francesca
Published: November 2022

The addition of molecular liquid cosolvents to choline chloride (ChCl)-based deep eutectic solvents (DESs) is increasingly investigated for reducing the inherently high bulk viscosities of the latter, which represent a major obstacle for potential industrial applications. The molar enthalpy of mixing, often referred to as excess molar enthalpy HE—a property reflecting changes in intermolecular interactions upon mixing—of the well-known ChCl/ethylene glycol (1:2 molar ratio) DES mixed with either water or methanol was recently found to be of opposite sign at 308.15 K: Mixing of the DES with water is strongly exothermic, while methanol mixtures are endothermic over the entire mixture composition range. Knowledge of molecular-level liquid structural changes in the DES following cosolvent addition is expected to be important when selecting such “pseudo-binary” mixtures for specific applications, e.g., solvents. With the aim of understanding the reason for the different behavior of selected DES/water or methanol mixtures, we performed classical MD computer simulations to study the changes in intermolecular interactions thought to be responsible for the observed HE sign difference. Excess molar enthalpies computed from our simulations reproduce, for the first time, the experimental sign difference and composition dependence of the property. We performed a structural analysis of simulation configurations, revealing an intriguing difference in the interaction modes of the two cosolvents with the DES chloride anion: water molecules insert between neighboring chloride anions, forming ionic hydrogen-bonded bridges that draw the anions closer, whereas dilution of the DES with methanol results in increased interionic separation. Moreover, the simulated DES/water mixtures were found to contain extended hydrogen-bonded structures containing water-bridged chloride pair arrangements, the presence of which may have important implications for solvent applications.
Maternal gestational Bifidobacterium bifidum TMC3115 treatment shapes construction of offspring gut microbiota and development of immune system and induces immune tolerance to food allergen
Authors: Cheng Ruyue , Zhang Yujie , Yang Yang , Ren Lei , Li Jinxing , Wang Yimei , Shen Xi , He Fang
Published: November 2022

In this study we aimed to determine whether treatment with maternal Bifidobacterium bifidum TMC3115 could affect the composition of the gut microbiota and the development of the immune system and intestinal tract of offspring, and protect the offspring from IgE-mediated allergic disease. Pregnant BALB/c mice were gavaged with TMC3115 until delivery. Offspring were sensitized with ovalbumin from postnatal days 21 to 49. After maternal treatment with TMC3115, the microbiota of the offspring’s feces, intestinal contents, and stomach contents (a proxy for breast milk) at the newborn and weaning stages exhibited the most change, and levels of immunoglobulin in the sera and stomach contents and of splenic cytokines, as well as the mRNA levels of colonic intestinal development indicators were all significantly altered in offspring at different stages. After sensitization with ovalbumin, there were no significant changes in the levels of serum IgE or ovalbumin-specific IgE/IgG1 in the TMC3115 group; however, IgM, the expression of intestinal development indicators, and the production of fecal short chain fatty acid (SCFA) were significantly increased, as were the relative abundances of Lactobacillus and the Lachnospiraceae NK4A136 group. Our results suggested that maternal treatment with TMC3115 could have a profound modulatory effect on the composition of the gut microbiota and the development of the immune system and intestinal tissue in offspring at different stages of development, and may induce immune tolerance to allergens in ovalbumin-stimulated offspring by modulating the gut microbiota and SCFA production.
Phosphatidylinositol 4-kinase is a viable target for the radical cure of Babesia microti infection in immunocompromised hosts
Authors: Ji Shengwei , Galon Eloiza May , Amer Moaz M. , Zafar Iqra , Yanagawa Masashi , Asada Masahito , Zhou Jinlin , Liu Mingming , Xuan Xuenan
Published: November 2022

Human babesiosis is a global emerging tick-borne disease caused by infection with intra-erythrocytic parasites of the genus Babesia. With the rise in human babesiosis cases, the discovery and development of new anti-Babesia drugs are essential. Phosphatidylinositol 4-kinase (PI4K) is a widely present eukaryotic enzyme that phosphorylates lipids to regulate intracellular signaling and trafficking. Previously, we have shown that MMV390048, an inhibitor of PI4K, showed potent inhibition against Babesia species, revealing PI4K as a druggable target for babesiosis. However, twice-administered, 7-day regimens failed to clear Babesia microti parasites from the immunocompromised host. Hence, in this study, we wanted to clarify whether targeting PI4K has the potential for the radical cure of babesiosis. In a B. microti-infected SCID mouse model, a 64-day-consecutive treatment with MMV390048 resulted in the clearance of parasites. Meanwhile, an atovaquone (ATO) resistant parasite line was isolated from the group treated with ATO plus azithromycin. A nonsynonymous variant in the Y272C of the cytochrome b gene was confirmed by sequencing. Likewise, MMV390048 showed potent inhibition against ATO-resistant parasites. These results provide evidence of PI4K as a viable drug target for the radical cure of babesiosis, which will contribute to designing new compounds that can eradicate parasites.
Risk factors and clinical effects of subclinical leaflet thrombosis after transcatheter aortic valve replacement
Authors: Bak Minjung , Park Sung-Ji , Choi Kihong , Kim Jihoon , Park Taek Kyu , Kim Eun Kyoung , Kim Sung Mok , Choi Seung-Hyuk
Published: November 2022

Aims

The number of trans-catheter aortic valve replacement (TAVR) procedure is increasing; However, the incidence of leaflet thrombosis is higher in TAVR than in surgical aortic valve replacement (SAVR). In this study, the risk factors for leaflet thrombosis after TAVR and its effects on hemodynamics and clinical course were investigated.

Methods and results

Multidetector computed tomography (MDCT) was performed at 1year after TAVR in 94 patients from January 2015 to October 2020 at Samsung Medical Center in South Korea. Among the 94 patients, subclinical leaflet thrombosis occurred in 20 patients, and risk factors were analyzed. In addition, the difference in aortic valve (AV) hemodynamics between the two groups was examined and clinical outcomes compared. Indexed mean sinus of Valsalva (SOV) diameter, AV calcium volume, and post-procedure effective orifice area (EOA) were predictive of subclinical leaflet thrombosis with the area under the curve (AUC) value of 0.670 (P-value = 0.020), 0.695 (P-value = 0.013), and 0.665 (P-value = 0.031), respectively. In echocardiography performed at the time of follow-up CT, the value of AV max velocity and AV mean pressure gradient were higher in the thrombosis group and the EOA and Doppler velocity index values were lower in the thrombosis group than in the no thrombosis group. Clinical outcome was not significantly different between the two groups (log-rank P-value = 0.26).

Conclusion

Larger indexed SOV diameter, higher AV calcium volume, and smaller post-procedure AV EOA were risk factors for subclinical leaflet thrombosis after TAVR. Subclinical leaflet thrombosis has a benign course when properly managed.
ESA-UNet for assisted diagnosis of cardiac magnetic resonance image based on the semantic segmentation of the heart
Authors: Li Yuanzhe , Liu Zhiqiang , Lai Qingquan , Li Shuting , Guo Yifan , Wang Yi , Dai Zhangsheng , Huang Jing
Published: November 2022

Background

Cardiovascular diseases have become the number one disease affecting human health in today's society. In the diagnosis of cardiac diseases, magnetic resonance image (MRI) technology is the most widely used one. However, in clinical diagnosis, the analysis of MRI relies on manual work, which is laborious and time-consuming, and also easily influenced by the subjective experience of doctors.

Methods

In this article, we propose an artificial intelligence-aided diagnosis system for cardiac MRI with image segmentation as the main component to assist in the diagnosis of cardiovascular diseases. We first performed adequate pre-processing of MRI. The pre-processing steps include the detection of regions of interest of cardiac MRI data, as well as data normalization and data enhancement, and then we input the images after data pre-processing into the deep learning network module of ESA-Unet for the identification of the aorta in order to obtain preliminary segmentation results, and finally, the boundaries of the segmentation results are further optimized using conditional random fields. For ROI detection, we first use standard deviation filters for filtering to find regions in the heart cycle image sequence where pixel intensity varies strongly with time and then use Canny edge detection and Hough transform techniques to find the region of interest containing the heart. The ESA-Unet proposed in this article, moreover, is jointly designed with a self-attentive mechanism and multi-scale jump connection based on convolutional networks.

Results

The experimental dataset used in this article is from the Department of CT/MRI at the Second Affiliated Hospital of Fujian Medical University. Experiments compare other convolution-based methods, such as UNet, FCN, FPN, and PSPNet, and the results show that our model achieves the best results on Acc, Pr, ReCall, DSC, and IoU metrics. After comparative analysis, the experimental results show that the ESA-UNet network segmentation model designed in this article has higher accuracy, intuitiveness, and more application value than traditional image segmentation algorithms.

Conclusion

With the continuous application of nuclear magnetic resonance technology in clinical diagnosis, the method in this article is expected to become a tool that can effectively improve the efficiency of doctors' diagnoses.
Trajectories and determinants of left ventricular ejection fraction after the first myocardial infarction in the current era of primary coronary interventions
Authors: Wohlfahrt Peter , Jenča Dominik , Melenovský Vojtěch , Šramko Marek , Kotrč Martin , Želízko Michael , Mrázková Jolana , Adámková Věra , Pitha Jan , Kautzner Josef
Published: November 2022

Background

Left ventricular ejection fraction (EF) is an independent predictor of adverse outcomes after myocardial infarction (MI). However, current data on trajectories and determinants of EF are scarce. The present study aimed to describe the epidemiology of EF after MI.

Methods

Data from a single-center prospectively-designed registry of consecutive patients hospitalized at a large tertiary cardiology center were utilized.

Results

Out of 1,593 patients in the registry, 1,065 were hospitalized for MI type I (65.4% STEMI) and had no previous history of heart failure or MI. At discharge, EF < 40% was present in 238 (22.3%), EF 40–50% in 326 (30.6%) and EF > 50% in 501 (47.0%). Patients with EF < 40% were often those who suffered subacute and anterior STEMI, had higher heart rate at admission and higher maximal troponin level, and had more often HF signs requiring intravenous diuretics. Among subjects with EF < 40%, the follow-up EF was available in 166 (80% of eligible). Systolic function recovered to EF > 50% in 39 (23.1%), slightly improved to EF 40–50% in 44 (26.0%) and remained below 40% in 86 (50.9%). Systolic function improvement to EF > 40% was predicted by lower severity of coronary atherosclerosis, lower leukocyte count, and the absence of atrial fibrillation.

Conclusions

Despite recent improvements in in-hospital MI care, one in five patients has systolic dysfunction at hospital discharge. Out of these, EF improves in 51%, and full recovery is observed in 23%. The severity of coronary atherosclerosis, inflammatory response to MI, and atrial fibrillation may affect EF recovery.