bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and quantification of honeybee venom constituents by multiplatform metabolomics
Authors: Klupczynska Agnieszka , Plewa Szymon , Dereziński Paweł , Garrett Timothy J. , Rubio Vanessa Y. , Kokot Zenon J. , Matysiak Jan
Published: December 2020

Honeybee (Apis mellifera) venom (HBV) has been a subject of extensive proteomics research; however, scarce information on its metabolite composition can be found in the literature. The aim of the study was to identify and quantify the metabolites present in HBV. To gain the highest metabolite coverage, three different mass spectrometry (MS)-based methodologies were applied. In the first step, untargeted metabolomics was used, which employed high-resolution, accurate-mass Orbitrap MS. It allowed obtaining a broad overview of HBV metabolic components. Then, two targeted metabolomics approaches, which employed triple quadrupole MS, were applied to quantify metabolites in HBV samples. The untargeted metabolomics not only confirmed the presence of amines, amino acids, carbohydrates, and organic acids in HBV, but also provided information on venom components from other metabolite classes (e.g., nucleosides, alcohols, purine and pyrimidine derivatives). The combination of three MS-based metabolomics platforms facilitated the identification of 214 metabolites in HBV samples, among which 138 were quantified. The obtaining of the wide free amino acid profiles of HBV is one of the project’s achievements. Our study contributed significantly to broadening the knowledge about HBV composition and should be continued to obtain the most comprehensive metabolite profile of HBV.
Immunoregulation induced by autologous serum collected after acute exercise in obese men: a randomized cross-over trial
Authors: Dorneles Gilson P. , da Silva Igor M. , Santos Maeli Andressa , Elsner Viviane R. , Fonseca Simone G. , Peres Alessandra , Romão Pedro R. T.
Published: December 2020

In this study, we evaluated the effects of autologous serum collected after two types of exercise on the in vitro inflammatory profile and T cell phenotype of resting peripheral blood mononuclear cells (PBMCs) in obese men. Serum samples and PBMCs were obtained from eight obese men who performed two exercise bouts—high intensity interval exercise (HIIE) and exhaustive exercise session to voluntary fatigue—in a randomized cross-over trial. Pre-exercise PBMCs were incubated with 50% autologous serum (collected before and after each exercise bout) for 4 h. In vitro experiments revealed that post-HIIE serum reduced the histone H4 acetylation status and NF-κB content of PBMCs and suppressed the production of both TNF-α and IL-6 by PBMCs, while increasing IL-10 production. Post-exhaustive exercise serum induced histone H4 hyperacetylation and mitochondrial depolarization in lymphocytes and increased TNF-α production. In vitro post-HIIE serum incubation resulted in an increase in the frequencies of CD4 + CTLA-4 + and CD4 + CD25+ T cells expressing CD39 and CD73. Post-exhaustive exercise serum decreased the frequency of CD4 + CD25 + CD73+ T cells but increased CD4 + CD25-CD39 + T cell frequency. Both post-exercise serums increased the proportions of CD4 + PD-1 + and CD8 + PD-1+ T cells. Blood serum factors released during exercise altered the immune response and T cell phenotype. The type of exercise impacted the immunomodulatory activity of the post-exercise serum on PBMCs.
Predicting Aedes aegypti infestation using landscape and thermal features
Authors: Lorenz Camila , Castro Marcia C. , Trindade Patricia M. P. , Nogueira Maurício L. , de Oliveira Lage Mariana , Quintanilha José A. , Parra Maisa C. , Dibo Margareth R. , Fávaro Eliane A. , Guirado Marluci M. , Chiaravalloti-Neto Francisco
Published: December 2020

Identifying Aedes aegypti breeding hotspots in urban areas is crucial for the design of effective vector control strategies. Remote sensing techniques offer valuable tools for mapping habitat suitability. In this study, we evaluated the association between urban landscape, thermal features, and mosquito infestations. Entomological surveys were conducted between 2016 and 2019 in Vila Toninho, a neighborhood of São José do Rio Preto, São Paulo, Brazil, in which the numbers of adult female Ae. aegypti were recorded monthly and grouped by season for three years. We used data from 2016 to 2018 to build the model and data from summer of 2019 to validate it. WorldView-3 satellite images were used to extract land cover classes, and land surface temperature data were obtained using the Landsat-8 Thermal Infrared Sensor (TIRS). A multilevel negative binomial model was fitted to the data, which showed that the winter season has the greatest influence on decreases in mosquito abundance. Green areas and pavements were negatively associated, and a higher cover of asbestos roofs and exposed soil was positively associated with the presence of adult females. These features are related to socio-economic factors but also provide favorable breeding conditions for mosquitos. The application of remote sensing technologies has significant potential for optimizing vector control strategies, future mosquito suppression, and outbreak prediction.
Evaluating the neuroprotective impact of senolytic drugs on human vision
Authors: El-Nimri Nevin W. , Moore Spencer M. , Zangwill Linda M. , Proudfoot James A. , Weinreb Robert N. , Skowronska-Krawczyk Dorota , Baxter Sally L.
Published: December 2020

Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression. However, disease-modifying, neuroprotective treatments for glaucoma remain a major unmet need. Recently, senescent cells have been observed in glaucomatous eyes, exposing a potential pathway for alternative glaucoma therapies. Prior studies demonstrated that targeting senescent RGCs for removal (i.e., a senolytic approach) protected healthy RGCs and preserved visual function in a mouse ocular hypertension model. However, the effects of senolytic drugs on vision in human patients are unknown. Here, we used existing clinical data to conduct a retrospective cohort study in 28 human glaucoma patients who had been exposed to senolytics. Senolytic exposure was not associated with decreased visual acuity, elevated intraocular pressure, or documentation of senolytic-related adverse ocular effects by treating ophthalmologists. Additionally, patients exposed to senolytics (n = 9) did not exhibit faster progression of glaucomatous visual field damage compared to matched glaucoma patients (n = 26) without senolytic exposure. These results suggest that senolytic drugs do not carry significant ocular toxicity and provide further support for additional evaluation of the potential neuroprotective effects of senolytics on glaucoma and other neurodegenerative diseases.
Increased risk of subsequent benign prostatic hyperplasia in non-Helicobacter pylori-infected peptic ulcer patients: a population-based cohort study
Authors: Fang Chu-Wen , Chen Chun-Hao , Shen Kun-Hung , Yang Wen-Chi , Muo Chih-Hsin , Wu Shih-Chi
Published: December 2020

The vagus nerve plays an essential role in homeostasis and inflammation. Clinically, peptic ulcer patients without helicobacter pylori (HP) infection may provide a population for studying the effect of vagal hyperactivity. There were interests in the association of gastrointestinal disease and urogenital disorders. Herein, we try to investigate subsequent risk of benign prostatic hyperplasia (BPH) in non-HP infected peptic ulcer patients. We identified 17,672 peptic ulcer admission male patients newly diagnosed in 1998–2007 from Taiwan Health Insurance Database, and 17,672 male comparison without peptic ulcer, frequency matched by age, and index-year. We assessed subsequent incidence of BPH in each cohort by the end of 2013, and then compared the risk of developing BPH between individuals with and without peptic ulcer. In addition, peptic ulcer patients underwent surgery were also examined. There were 2954 peptic ulcer patients and 2291 comparisons noted with the occurrence of BPH (25.35 and 16.70 per 1000 person-years, respectively). Compared to comparisons, peptic ulcer patients had a 1.45- and 1.26-fold BPH risk in multivariable Cox model and Fine and Gray model (95% CI 1.37–1.54 and 1.19–1.34). In age-stratified analysis, the highest risk of BPH was in 45–59 years (interaction p < 0.05). Regarding surgery types, peptic ulcer patients who underwent simple suture surgery (i.e.: with integrated vagus nerve) had a significant higher BPH risk than comparison (HR 1.50 and 95% CI 1.33–1.74; SHR 1.26 and 95% CI 1.07–1.48), while patients underwent truncal vagotomy/pyloroplasty showed a lower incidence of BPH. In this study, non-HP-infected male peptic ulcer patients were found to have an increased risk of subsequent BPH. Indicating that there might be a role of vagus nerve. Based on the limitations of retrospective nature, further studies are required.
Comparing the effects of a mindfulness versus relaxation intervention on romantic relationship wellbeing
Authors: Karremans Johan C. , Kappen Gesa , Schellekens Melanie , Schoebi Dominik
Published: December 2020

There is increasing scientific interest in the potential association between mindfulness and romantic relationship wellbeing. To date, however, experimental studies using active control groups and testing dyadic effects (i.e. examining both actor and partner effects) are lacking. In the current study, romantically involved individuals engaged for 2 weeks daily in either guided mindfulness exercises, or guided relaxation exercises. Participants, and their partners, completed measures of relationship wellbeing at pre- and post-intervention, and at 1-month follow up. The mindfulness intervention significantly promoted relationship wellbeing, for both participants (i.e. actor effects) and their partners (i.e. partner effects). However, these findings did not significantly differ from changes in relationship wellbeing in the relaxation condition. Theoretical implications of these findings for understanding the association between mindfulness and romantic relationship wellbeing are discussed. Moreover, the findings are discussed in light of recent debates about the relative lack of proper control groups in mindfulness research.
Machine learning to reveal hidden risk combinations for the trajectory of posttraumatic stress disorder symptoms
Authors: Takahashi Yuta , Yoshizoe Kazuki , Ueki Masao , Tamiya Gen , Zhiqian Yu , Utsumi Yusuke , Sakuma Atsushi , Tsuda Koji , Hozawa Atsushi , Tsuji Ichiro , Tomita Hiroaki
Published: December 2020

The nature of the recovery process of posttraumatic stress disorder (PTSD) symptoms is multifactorial. The Massive Parallel Limitless-Arity Multiple-testing Procedure (MP-LAMP), which was developed to detect significant combinational risk factors comprehensively, was utilized to reveal hidden combinational risk factors to explain the long-term trajectory of the PTSD symptoms. In 624 population-based subjects severely affected by the Great East Japan Earthquake, 61 potential risk factors encompassing sociodemographics, lifestyle, and traumatic experiences were analyzed by MP-LAMP regarding combinational associations with the trajectory of PTSD symptoms, as evaluated by the Impact of Event Scale-Revised score after eight years adjusted by the baseline score. The comprehensive combinational analysis detected 56 significant combinational risk factors, including 15 independent variables, although the conventional bivariate analysis between single risk factors and the trajectory detected no significant risk factors. The strongest association was observed with the combination of short resting time, short walking time, unemployment, and evacuation without preparation (adjusted P value = 2.2 × 10−4, and raw P value = 3.1 × 10−9). Although short resting time had no association with the poor trajectory, it had a significant interaction with short walking time (P value = 1.2 × 10−3), which was further strengthened by the other two components (P value = 9.7 × 10−5). Likewise, components that were not associated with a poor trajectory in bivariate analysis were included in every observed significant risk combination due to their interactions with other components. Comprehensive combination detection by MP-LAMP is essential for explaining multifactorial psychiatric symptoms by revealing the hidden combinations of risk factors.
An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification
Authors: Cai Hongmin , Yao Hebang , Li Tingting , Hutter Cedric A. J. , Li Yanfang , Tang Yannan , Seeger Markus A. , Li Dianfan
Published: December 2020

Green fluorescent proteins (GFPs) are widely used to monitor membrane protein expression, purification, and stability. An ideal reporter should be stable itself and provide high sensitivity and yield. Here, we demonstrate that a coral (Galaxea fascicularis) thermostable GFP (TGP) is by such reasons an improved tag compared to the conventional jellyfish GFPs. TGP faithfully reports membrane protein stability at temperatures near 90 °C (20-min heating). By contrast, the limit for the two popular GFPs is 64 °C and 74 °C. Replacing GFPs with TGP increases yield for all four test membrane proteins in four expression systems. To establish TGP as an affinity tag for membrane protein purification, several high-affinity synthetic nanobodies (sybodies), including a non-competing pair, are generated, and the crystal structure of one complex is solved. Given these advantages, we anticipate that TGP becomes a widely used tool for membrane protein structural studies.
Stratospheric drivers of extreme events at the Earth’s surface
Authors: Domeisen Daniela I. V. , Butler Amy H.
Published: December 2020

The stratosphere, the layer of the atmosphere at heights between 10-50 km, is an important source of variability for the weather and climate at the Earth’s surface on timescales of weeks to decades. Since the stratospheric circulation evolves more slowly than that of the troposphere below, it can contribute to predictability at the surface. Our synthesis of studies on the coupling between the stratosphere and the troposphere reveals that the stratosphere also contributes substantially to a wide range of climate-related extreme events. These extreme events include cold air outbreaks and extreme heat, air pollution, wildfires, wind extremes, and storm clusters, as well as changes in tropical cyclones and sea ice cover, and they can have devastating consequences for human health, infrastructure, and ecosystems. A better understanding of the vertical coupling in the atmosphere, along with improved representation in numerical models, is therefore expected to help predict extreme events on timescales from weeks to decades in terms of the event type, magnitude, frequency, location, and timing. With a better understanding of stratosphere-troposphere coupling, it may be possible to link more tropospheric extremes to stratospheric forcing, which will be crucial for emergency planning and management.
Artificial Intelligence as an Enabler for Phenotypic Drug Discovery
Authors: Renaud Nicole , Wang Yuan
Published: December 2020

Phenotypic drug discovery focuses on screening for an effect in cells (the phenotype) while being agnostic to the mechanism and target of the compound. Here we describe the use of computational methods, notably artificial intelligence, to accelerate each step of phenotypic drug discovery. Starting with assay development, machine learning can be used to prioritize good chemical probes to help the project team design and validate a robust screen. During hit discovery and triage, an iterative screening and machine-learning strategy can enable screening in complex cell models that would otherwise not be amenable. During target deconvolution and lead optimization computational models capitalize on decades of science to prioritize target hypotheses using data from orthogonal platforms both within our organization and outside. Finally, we end with an outlook and overview of emerging methods. Critical to these steps are not only the computational methods but also well-organized, curated data that capture the history of experiments. The acceleration is enabled by first making our data machine-learnable in order to apply machine learning.
Antibody-based Phenotypic Screening – the Discovery of Oleclumab (MEDI9447)
Authors: Minter Ralph , Sachsenmeier Kris , Cooper Zachary A. , Rust Steven
Published: December 2020

Phenotypic antibody drug discovery, which takes a target-agnostic approach, remains an under-utilised strategy in an industry where target-led antibody drug discovery is dominant. However, there are strong arguments in support of the phenotypic approach as it promises the fast-track identification of novel molecular targets as well as uncovering new areas of unexplored target biology. This chapter discusses the use of antibody phenotypic screening for the discovery of novel monoclonal antibodies and the identification of CD73 as a new oncology target. The phenotypic approach led to an early stake in the emerging area of adenosine-mediated immune suppression in tumours and led directly to the development of oleclumab, a first-in-class anti-CD73 antibody, now under investigation in clinical trials.
Bioconjugation of 2-arachidonoyl glycerol (2-AG) biotinylated antibody with gold nano-flowers toward immunosensing of 2-AG in human plasma samples: A novel immuno-platform for the screening of immunomodulation and neuroprotection using biosensing
Authors: Mobed Ahmad , Kohansal Fereshteh , Ahmadalipour Ali. , Hasanzadeh Mohammad , Zargari Flor
Published: December 2020

Human 2-arachidonoylglycerol (2-AG) is an agonist of endocannabinoid system and acts as an important modulator of many physiological processes such as emotional state and pain sensation.
Receptor mimicking TGF-β1 binding peptide for targeting TGF-β1 signaling
Authors: Belair David G. , Lee Jae Sung , Kellner Anna V. , Huard Johnny , Murphy William L.
Published: December 2020

Transforming growth factor-β1 (TGF-β1) binding peptides were developedviabiomimicry of the TGF-β1/TGF-β receptor complex to attenuate biological activity of TGF-β1 when presented either in soluble form or conjugated to synthetic biomaterials.
4T1 cell membrane fragment reunited PAMAM polymer units disguised as tumor cell clusters for tumor homotypic targeting and anti-metastasis treatment
Authors: Pei Xiaochen , Pan Xiuhua , Xu Xiaoyi , Xu Xiang , Huang Haiqin , Wu Zhenghong , Qi Xiaole
Published: December 2020

Cell membrane-based nanoparticles have garnered increasing attention owing to their inherent biomimetic properties, such as homotypic targeting, prolong circulation, and immune escaping mechanisms.
PD-L1 cellular nanovesicles carrying rapamycin inhibit alloimmune responses in transplantation
Authors: Yang Min , Xu Zhanxue , Yan Hailan , Tsai Hsiang-i , Su Dandan , Yan Fuxia , Lu Qiumei , Feng Jianhua , Zeng Weiwei , Xi Lifang , Zha Hualian , Ling Yunzhi , He Chao , Wu Yingyi , Xu Xiaowei , Zheng Gang , Liu Gan , Chen Hongbo , Cheng Fang
Published: December 2020

PD-L1 nanovesicles carrying rapamycin inhibit T cell activation to promote allograft acceptance.
A novel electrochemical biosensor for ultrasensitive Hg2+ detection via a triple signal amplification strategy
Authors: He Wang , Qiao Bin , Li Fengzhen , Pan Lisha , Chen Delun , Cao Yang , Tu Jinchun , Wang Xiaohong , Lv Chuanzhu , Wu Qiang
Published: December 2020

We report a novel electrochemical biosensor for the ultrasensitive Hg2+ detection via a signal amplification strategy. This strategy could be easily modified and extended to detect other hazardous heavy metals and nucleic acid.
Hydroxyapatite supported molybdenum oxide catalyst for selective oxidation of methanol to formaldehyde: studies of industrial sized catalyst pellets
Authors: Thrane Joachim , Mentzel Uffe Vie , Thorhauge Max , Høj Martin , Jensen Anker Degn
Published: December 2020

Promising alternative catalysts for the Formox process as industrial sized pellets and the influence of pellet density on catalyst performance.
CO2 conversion over Cu–Mo2C catalysts: effect of the Cu promoter and preparation method
Authors: Heracleous Eleni , Koidi Vasiliki , Lappas Angelos A.
Published: December 2020

Strong interaction between the Cu and Mo2C phases and formation of Mo2C–Cu+ interfaces is required for the efficient hydrogenation of CO2 to methanol.
Recent advances and perspectives in manganese-catalyzed C–H activation
Authors: Aneeja Thaipparambil , Neetha Mohan , Afsina C. M. A. , Anilkumar Gopinathan
Published: December 2020

Manganese-catalyzed C–H activation has become an emerging area in organic chemistry. These efficient and eco-friendly manganese catalysed reactions provides new opportunities in the field of synthetic organic chemistry.
Effect of extrusion processing and addition of purple sweet potatoes on the structural properties and in vitro digestibility of extruded rice
Authors: Wang Jiejie , Li Mengfei , Wang Chun , Dai Yanjun , Sun Yue , Li Xueling , Heider Camren G. , Wu Xian , Liang Jin
Published: December 2020

Recently, extruded rice as a functional ingredient has been a hot area of research in food processing.
Multi-omics reveals the anticancer mechanism of asparagus saponin-asparanin A on endometrial cancer Ishikawa cells
Authors: Zhang Fan , Zhang Yuan-Yuan , Ma Run-Hui , Thakur Kiran , Han Jinzhi , Hu Fei , Zhang Jian-Guo , Wei Zhao-Jun
Published: December 2020

Multi-omics reveals that AA not only induced apoptosis, but also triggered autophagy in Ishikawa cells through ER stress and DNA damage-related pathways.
Dietary supplementation with aromatic amino acids decreased triglycerides and alleviated hepatic steatosis by stimulating bile acid synthesis in mice
Authors: Ma Qingquan , Chen Jiayi , Zhou Xinbo , Hu Linlin , Sun Yuchen , Wang Zhishen , Yue Zhiyuan , Shan Anshan
Published: December 2020

Increased aromatic amino acids intake improved lipid metabolism by stimulating bile acid synthesis.
Fermented ginseng attenuates lipopolysaccharide-induced inflammatory responses by activating the TLR4/MAPK signaling pathway and remediating gut barrier
Authors: Fan Jingjing , Liu Sitong , Ai Zhiyi , Chen Yiying , Wang Yonghong , Li Youbao , Li Xia , Xiao Shengyuan , Wang Yuhua
Published: December 2020

Generally, ginsenosides have the physiological effect of an anti-inflammatory immunity.
A recent update on the multifaceted health benefits associated with ginger and its bioactive components
Authors: Ma Run-Hui , Ni Zhi-Jing , Zhu Yun-Yang , Thakur Kiran , Zhang Fan , Zhang Yuan-Yuan , Hu Fei , Zhang Jian-Guo , Wei Zhao-Jun
Published: December 2020

The bioactive compounds and bioactivities of ginger, and their detailed mechanisms including some therapeutic effects of ginger and its constituents for effective antioxidant properties were comprehensive reviewed.
Pourbaix sensors in polyurethane molecular logic-based coatings for early detection of corrosion
Authors: Scerri Glenn J. , Spiteri Jake C. , Magri David C.
Published: December 2020

Corrosion is detected by logic-based molecules before it is visible to the naked eye.
Dynamic degradation of metallic nanowire networks under electrical stress: a comparison between experiments and simulations
Authors: Charvin Nicolas , Resende Joao , Papanastasiou Dorina T. , Muñoz-Rojas David , Jiménez Carmen , Nourdine Ali , Bellet Daniel , Flandin Lionel
Published: December 2020

We describe the degradation mechanism in a metallic nanowire network subjected to electrical stress. The nanowire network degradation is ascribed, at a very local scale, to hot-spot formation and the subsequent propagation of a spatially correlated disruptive crack.
Synthesis of Janus Au@BCP nanoparticles via UV light-initiated RAFT polymerization-induced self-assembly
Authors: Liu Zhenzhong , Wu Chenglin , Fu Yabo , Xu Xinlei , Ying Jialei , Sheng Jiansong , Huang Youju , Ma Chunxin , Chen Tao
Published: December 2020

A Janus Au@BCP nanoparticle, with a controllable size and morphology, was explored via fast and simple UV light-initiated RAFT PISA.
Silver telluride nanoparticles as biocompatible and enhanced contrast agents for X-ray imaging: an in vivo breast cancer screening study
Authors: Nieves Lenitza M. , Hsu Jessica C. , Lau Kristen C. , Maidment Andrew D. A. , Cormode David P.
Published: December 2020

Silver telluride nanoparticles (Ag2Te NPs) show good biocompatibility, enhanced contrast, and blood pool agent characteristics and thus could be used contrast agents for breast cancer screening.
Luminescent net-like inorganic scaffolds with europium-doped hydroxyapatite for enhanced bone reconstruction
Authors: Liu Min , Shu Mengmeng , Yan Jiaqing , Liu Xuxu , Wang Ruifeng , Hou Zhiyao , Lin Jun
Published: December 2020

Luminescent net-like inorganic scaffolds with Eu3+-doped hydroxyapatite were firstly synthesized by the one-step hydrothermal method and thiol–ene click reaction.
Nanocarrier-based activation of necroptotic cell death potentiates cancer immunotherapy
Authors: Xia Gan-Qing , Lei Tian-Run , Yu Teng-Bo , Zhou Pang-Hu
Published: December 2020

The injection of liposomes loaded with TNF-α avoids adverse effects and enhances the therapeutic effect of PD-L1 antibody.
On the strong connection between nanoscale adhesion of Yad fimbriae and macroscale attachment of Yad-decorated bacteria to glycosylated, hydrophobic and hydrophilic surfaces
Authors: Francius Grégory , Petit Florian , Clément Eloïse , Chekli Yankel , Ghigo Jean-Marc , Beloin Christophe , Duval Jérôme F. L.
Published: December 2020

Combination of microbial assays and Single Molecule Force Spectroscopy evidence nano–macro relationship in adhesion properties ofE. coliexpressing Yad fimbriae. Affinity of Yad fimbriae for xylose is as strong as that for YadC and YadN antibodies.
Intracellular optical probing with gold nanostars
Authors: Spedalieri Cecilia , Szekeres Gergo Peter , Werner Stephan , Guttmann Peter , Kneipp Janina
Published: December 2020

The morphology of non-functionalized gold nanostars determines the surface protein structure and their interaction with the endolysosomal compartment in cells.
Simulating selective binding of a biological template to a nanoscale architecture: a core concept of a clamp-based binding-pocket-favored N-terminal-domain assembly
Authors: Li Lunna , Belcher Angela M. , Loke Desmond K.
Published: December 2020

A biological template and its mutants have vital significance in next generation remediation, electrochemical, photovoltaic, catalytic, sensing and digital memory devices.
Post-translational modifications soften vimentin intermediate filaments
Authors: Kraxner Julia , Lorenz Charlotta , Menzel Julia , Parfentev Iwan , Silbern Ivan , Denz Manuela , Urlaub Henning , Schwappach Blanche , Köster Sarah
Published: December 2020

We mechanically tested partially phosphorylated vimentin intermediate filaments using optical traps and found that the additional charges considerably soften the filaments.
Advanced nitric oxide donors: chemical structure of NO drugs, NO nanomedicines and biomedical applications
Authors: Yang Yueqi , Huang Zhangjian , Li Li-Li
Published: December 2020

Nitric oxide (NO), as an endogenous diatomic molecule, plays a key regulatory role in many physiological and pathological processes.
Size-controlled nanocrystals reveal spatial dependence and severity of nanoparticle coalescence and Ostwald ripening in sintering phenomena
Authors: Goodman Emmett D. , Carlson Evan Z. , Dietze Elisabeth M. , Tahsini Nadia , Johnson Arun , Aitbekova Aisulu , Nguyen Taylor Temy , Plessow Philipp N. , Cargnello Matteo
Published: December 2020

Colloidal nanocrystals allow investigating sintering phenomena in supported catalysts.
Long-term can-sealing protection: a stable black phosphorus nanoassembly achieved through heterogeneous hydrophobic functionalization
Authors: Pai Ying-Hao , Chen Chun-Hua
Published: December 2020

Hydrophobic Al2O3 columnar cappings have been demonstrated as promising candidates for comprehensive protection against severe rapid degradation of pristine black phosphorus even under a very high-humidity environment (RH = 85%) for an extended period.
Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones
Authors: Reznichenko Oksana , Cucchiarini Anne , Gabelica Valérie , Granzhan Anton
Published: December 2020

Synthesis of dynamic combinatorial libraries of acylhydrazones in the presence of a G-quadruplex DNA template, followed by pull-down with streptavidin-coated magnetic beads, allows the identification of putative G-quadruplex binders.
Synthesis of functionalised 2,3-dihydroquinolin-4(1H)-ones vs. quinoline or N-alkenylindole derivatives through sequential reactions of 2-alkynylanilines with ketones
Authors: Marsicano Vincenzo , Arcadi Antonio , Chiarini Marco , Fabrizi Giancarlo , Goggiamani Antonella , Iazzetti Antonia
Published: December 2020

The diversity-oriented synthesis of 2,2,3-substituted-2,3-dihydroquinolin-4(1H)-ones vs. functionalised quinoline or N-alkenylindole derivatives is described.
A new air-stable Si,S-chelating ligand for Ir-catalyzed directed ortho C–H borylation
Authors: Jiao Jiao , Nie Wenzheng , Song Peidong , Li Pengfei
Published: December 2020

A new air-stable Si,S-chelating ligand has been developed and used in an iridium-catalyzed ortho C–H borylation reaction with a broad substrate scope.
The first observation on polymerization of 1,3-benzothiazines: synthesis of mono- and bis-thiazine monomers and thermal properties of their polymers
Authors: Ohashi Seishi , Rachita Eric , Baxley Sean , Zhou Jessica , Erlichman Adam , Ishida Hatsuo
Published: December 2020

Mono and difunctional 1,3-benzothiazines (PH-a-BZT, PH-ddm-BZT) have been synthesized by a method different from the one reported in the literature.
The effect of polarity on the molecular exchange dynamics in imine-based covalent adaptable networks
Authors: Schoustra Sybren K. , Groeneveld Timo , Smulders Maarten M. J.
Published: December 2020

Polarity-induced effects in dynamic covalent polyimine CANs were studied, revealing a three-step stress relaxation process.
Facile intramolecular crosslinking of polymers by metallic coordination in concentrated solutions
Authors: Xu Wei , Xiang Dao , Xu Jingjing , Ye Yilan , Qiu Dong , Yang Zhenzhong
Published: December 2020

Single chain nanoparticles are obtained by intramolecular metallic coordination in concentrated solutions at ambient temperature.
Development of a “single-click” analytical platform for the detection of cannabinoids in hemp seed oil
Authors: Risoluti Roberta , Gullifa Giuseppina , Battistini Alfredo , Materazzi Stefano
Published: December 2020

In this work, an innovative screening platform is developed and validated for the on site detection of cannabinoids in hemp seed oil, for food safety control of commercial products.
A study on the electrochemical behavior of hydroquinone at a nanometer cobalt/l-glutamate-modified electrode
Authors: Huang Baomei , Yao Chengwei , Yang Jing , Du Shizhuang , Lu Xiaoquan
Published: December 2020

A new electrochemical sensor for hydroquinone (HQ) was prepared.
Preparation of antistatic epoxy resin coatings based on double comb-like quaternary ammonium salt polymers
Authors: Gao Wei , Dang Zeng-chao , Liu Fu-sheng , Wang Sheng , Zhang Duan-wei , Yan Meng-xi
Published: December 2020

The antistatic epoxy resin coatings using double comb-like quaternary ammonium salt polymers as antistatic agents reach good antistatic property with lower addition amount because polymers can dissolve and nearly linearly arrange in the coatings.
Magnetically responsive polycaprolactone nanocarriers for application in the biomedical field: magnetic hyperthermia, magnetic resonance imaging, and magnetic drug delivery
Authors: Szczęch Marta , Orsi Davide , Łopuszyńska Natalia , Cristofolini Luigi , Jasiński Krzysztof , Węglarz Władysław P. , Albertini Franca , Kereïche Sami , Szczepanowicz Krzysztof
Published: December 2020

There are huge demands on multifunctional nanocarriers to be used in nanomedicine.
Zero-field slow relaxation of magnetization in cobalt(ii) single-ion magnets: suppression of quantum tunneling of magnetization by tailoring the intermolecular magnetic coupling
Authors: Mitsuhashi Ryoji , Hosoya Satoshi , Suzuki Takayoshi , Sunatsuki Yukinari , Sakiyama Hiroshi , Mikuriya Masahiro
Published: December 2020

Quenching of quantum tunneling of magnetization was observed in a tetrahedral cobalt(ii) complex with 1-D chain hydrogen-bond networks by partially substituting the CoII ion with the ZnII ion, up to 33%.
Thermoelectric properties of flexible PEDOT:PSS-based films tuned by SnSe via the vacuum filtration method
Authors: Yan Zhuqing , Zhao Yaxin , Liu Dan , Zhang Zhidong , Zheng Yongqiu , Cui Juan , Zhang Yanjun , Xue Chenyang
Published: December 2020

In this study, SnSe was introduced to enhance the thermoelectric property of PEDOT:PSS flexible film by the vacuum filtration method, 10 wt% SnSe/PEDOT:PSS film exhibits excellent stability and thermoelectric property, which may be applied for wearable devices.
Zeolitic imidazolate framework (ZIF)-derived porous carbon materials for supercapacitors: an overview
Authors: Ahmad Rabia , Khan Usman Ali , Iqbal Naseem , Noor Tayyaba
Published: December 2020

The present analysis focuses on the synthetic methods used for the application of supercapacitors with various mysterious architectures derived from zeolitic imidazolate frameworks (ZIFs).
Stability study of organometal halide perovskite and its enhanced X-ray scintillation from the incorporation of anodic TiO2nanotubes
Authors: Li Hui , Chen Zhenhua , Sang Zhuocheng , Zhang Xiangzhi , Wang Yong
Published: December 2020

Organometal halide perovskite-based optoelectronic devices are currently a hot research area owing to their unique properties, but widespread commercialization is plagued by their poor long-term stability.
Crystalline phase regulation of anatase–rutile TiO2 for the enhancement of photocatalytic activity
Authors: Wang Kuang , Zhuo Yan , Chen Jiayi , Gao Dawei , Ren Yu , Wang Chunxia , Qi Zhenming
Published: December 2020

Biphasic TiO2 with adjustable crystalline phases was prepared by the hydrothermal-calcination method assisted by nitric acid (HNO3) and hydrogen peroxide (H2O2), using potassium titanate oxalate (K2TiO(C2O4)2) as the titanium source.
Solvent-free manufacture of methacrylate polymers from biomass pyrolysis products
Authors: Ryan J. , Elsmore M. T. , Binner E. R. , De Focatiis D. S. A. , Irvine D. J. , Robinson J. P.
Published: December 2020

Biomass pyrolysis liquid is functionalised into a potential replacement for petrochemical derived methacrylates used in resins, adhesives and binders.
One class classification as a practical approach for accelerating π–π co-crystal discovery
Authors: Vriza Aikaterini , Canaj Angelos B. , Vismara Rebecca , Kershaw Cook Laurence J. , Manning Troy D. , Gaultois Michael W. , Wood Peter A. , Kurlin Vitaliy , Berry Neil , Dyer Matthew S. , Rosseinsky Matthew J.
Published: December 2020

Machine learning using one class classification on a database of existing co-crystals enables the identification of co-formers which are likely to form stable co-crystals, resulting in the synthesis of two co-crystals of polyaromatic hydrocarbons.
Hydration breaking and chemical ordering in a levitated NaCl solution droplet beyond the metastable zone width limit: evidence for the early stage of two-step nucleation
Authors: Hwang Hyerim , Cho Yong Chan , Lee Sooheyong , Lee Yun-Hee , Kim Seongheun , Kim Yongjae , Jo Wonhyuk , Duchstein Patrick , Zahn Dirk , Lee Geun Woo
Published: December 2020

This work provides evidence for two-step nucleation in highly supersaturated bulk NaCl solution, using electrostatic levitation combined with Raman/X-ray scatterings.
Synthesis of N-aryl amines enabled by photocatalytic dehydrogenation
Authors: Kim Jungwon , Kim Siin , Choi Geunho , Lee Geun Seok , Kim Donghyeok , Choi Jungkweon , Ihee Hyotcherl , Hong Soon Hyeok
Published: December 2020

The synergy of SET, HAT, and BET enables a visible-light induced catalytic dehydrogenation for the synthesis of N-aryl amines.
Transition-metal-mediated reduction and reversible double-cyclization of cyanuric triazide to an asymmetric bitetrazolate involving cleavage of the six-membered aromatic ring
Authors: Vaddypally Shivaiah , Kiselev Vitaly G. , Byrne Alex N. , Goldsmith C. Franklin , Zdilla Michael J.
Published: December 2020

Cyanuric triazide reacts with transition metal precursors, extruding N2 and reducing the ligand by two electrons, which breaks an aromatic ring and rearranges to a bitetrazolylmethanediiminate (biTzI2−) ligand, forming two new aromatic rings.
Cerium(iv) complexes with guanidinate ligands: intense colors and anomalous electronic structures
Authors: Qiao Yusen , Yin Haolin , Moreau Liane M. , Feng Rulin , Higgins Robert F. , Manor Brian C. , Carroll Patrick J. , Booth Corwin H. , Autschbach Jochen , Schelter Eric J.
Published: December 2020

A series of cerium(iv) mixed-ligand guanidinate-amide complexes, {[(Me3Si)2NC(NiPr)2]xCeIV[N(SiMe3)2]3−x}+ (x= 0−3), was prepared by chemical oxidation and studied spectroscopically and computationally, revealing trends in 4f/5d orbital occupancies.
Elucidating dissociation activation energies in host–guest assemblies featuring fast exchange dynamics
Authors: Shusterman-Krush Ronit , Grimm Laura , Avram Liat , Biedermann Frank , Bar-Shir Amnon
Published: December 2020

GEST-NMR is utilized for quantifying the dissociation activation energy (Ea,out) in host-guest systems featuring fast dissociation dynamics.
Effects of turn-structure on folding and entanglement in artificial molecular overhand knots
Authors: Song Yiwei , Schaufelberger Fredrik , Ashbridge Zoe , Pirvu Lucian , Vitorica-Yrezabal Iñigo J. , Leigh David A.
Published: December 2020

Spacers linking 2,6-pyridinedicarboxamide units influence the tightness of the corresponding lanthanide-coordinated overhand knot. β-Hairpin forming motifs generate a metal-coordinated pseudopeptide with a knotted tertiary structure.
Intermolecular oxidative amination of unactivated alkenes by dual photoredox and copper catalysis
Authors: Yi Xiangli , Hu Xile
Published: December 2020

Oxidative aminationviaamidyl radical addition of unactivated alkenes was realized by dual photoredox and copper catalysis.
Annealing-induced evolution at the LiCoO2/LiNbO3 interface and its functions in all-solid-state batteries with a Li10GeP2S12 electrolyte
Authors: Sun Xueying , Hori Satoshi , Li Yuxiang , Yamada Yuto , Suzuki Kota , Hirayama Masaaki , Kanno Ryoji
Published: December 2020

This work addresses the mechanism of the interfacial evolution for LiNbO3-coated LiCoO2 under the high-temperature annealing process.
Recent advances of hydrogel electrolytes in flexible energy storage devices
Authors: Chan Cheuk Ying , Wang Ziqi , Jia Hao , Ng Pui Fai , Chow Lung , Fei Bin
Published: December 2020

Review on the recent advances of gel polymer electrolytes in flexible energy storage devices and their additional functions.
Reduction tuning of ultrathin carbon shell armor covering IrP2 for accelerated hydrogen evolution kinetics with Pt-like performance
Authors: Yu Wen-Li , Chi Jing-Qi , Dong Bin
Published: December 2020

Developing highly durable electrocatalysts for hydrogen evolution via water splitting over a wide pH range has become increasingly necessary for renewable energy systems.
The facile oil-phase synthesis of a multi-site synergistic high-entropy alloy to promote the alkaline hydrogen evolution reaction
Authors: Zhang Dan , Shi Yue , Zhao Huan , Qi Wenjing , Chen Xilei , Zhan Tianrong , Li Shaoxiang , Yang Bo , Sun Mingzi , Lai Jianping , Huang Bolong , Wang Lei
Published: December 2020

Although intensive efforts have been made and great progress has been achieved relating to the electrocatalytic hydrogen evolution reaction (HER), an advanced synthesis strategy for an efficient electrocatalyst is still the most significant goal.
Utilizing spent Li-ion batteries to regulate the π-conjugated structure of g-C3N4: a win–win approach for waste recycling and highly active photocatalyst construction
Authors: Niu Bo , Xiao Jiefeng , Xu Zhenming
Published: December 2020

This study utilizes spent LIBs to regulate the π-conjugated structure of g-C3N4, which realizes an all-win situation for waste recycling, highly active photocatalyst construction and environmental protection.
Activity of layered swedenborgite structured Y0.8Er0.2BaCo3.2Ga0.8O7+δ for oxygen electrode reactions in at intermediate temperature reversible ceramic cells
Authors: Shin Ji-Seop , Park Hyunyoung , Park Kwangho , Saqib Muhammad , Jo Minkyeong , Kim Jung Hyun , Lim Hyung-Tae , Kim Minseuk , Kim Jongsoon , Park Jun-Young
Published: December 2020

A new class of layered swedenborgite structured Y0.8Er0.2BaCo3.2Ga0.8O7+δ is proposed for oxygen electrode reactions in reversible ceramic cells because of its low thermal expansion and high chemical bulk diffusion coefficients.
Multifunctional spinel MnCo2O4 based materials for energy storage and conversion: a review on emerging trends, recent developments and future perspectives
Authors: Gonçalves Josué M. , Silva Murillo N. T. , Naik Kusha Kumar , Martins Paulo R. , Rocha Diego P. , Nossol Edson , Munoz Rodrigo A. A. , Angnes Lucio , Rout Chandra Sekhar
Published: December 2020

In this review, electrocatalysts for HER/OER/ORR and energy storage electrode materials based on MnCo2O4 were reviewed considering their key multifunctional role in the way to a more sustainable society.
Conférence d'ouverture : Nous nous sommes tant aimés. Retour sur les approches non-formelles de la conception architecturale à l’ère numérique
Authors: Estevez Daniel
Published: December 2020

L’article propose une analyse épistémologique de certains outils et méthodes de conception en architecture y compris en contexte numérique. Il s’appuie sur des expériences didactiques auxquelles l’auteur a participé sous forme d’ateliers, de workshop, de chantiers etc. Ces recherches sont souvent redevables aux leçons provenant du champ de l’art et à celles qui émanent des recherches pragmatistes qui se sont déroulées dans la dernière partie du XXème siècle. L’article décrit quatre situationstype de conception en architecture et leurs postures de conception sous jacentes. L’hypothèse de cette analyse est que le travail de conception peut être stimulé et déployé à partir de certaines migrations précises que le sujet-concepteur peut accomplir. Passant d’une posture à une autre dans une situation donnée, le concepteur augmente sa puissance d’agir face à des demandes complexes. L’article montre à travers un exemple comment ces migrations, propres aux démarches de conception non-formelle, peuvent parfaitement intégrer les contextes numériques de conception.
The Polar Cap (PC) index combination, PCC: relations to solar wind properties and global magnetic disturbances
Authors: Stauning Peter
Published: December 2020

The non-negative Polar Cap PCC index built from PCN (North) and PCS (South) indices correlates better with the solar wind merging electric field and is more representative for the total energy input from the solar wind to the magnetosphere and for the development of geomagnetic disturbances represented by the Kp index and ring current indices than either of the hemispheric indices. The present work shows that the ring current index, Dst, to a high degree of accuracy can be derived from a source function built from PCC indices. The integration of the PCC-based source function throughout the interval from 1992 to 2018 without attachment to the real Dst indices based on low latitude magnetic observations has generated equivalent Dst values that correlate very well (R = 0.86) with the real Dst index values, which are represented with a mean deviation less than 1 nT and an overall RMS deviation less than 13 nT. The precise correlation between the real and equivalent Dst values has been used to correct the PCC indices for saturation effects at high intensity disturbance conditions where the Dst index may take values beyond −100 nT. The relations between PCC and the ring current indices, Dst and ASY-H have been used, in addition, to derive the precise timing between polar cap convection processes reflected in the polar cap indices and the formation of the partial and total ring current systems. Building the ring current is considered to represent the energy input from the solar wind, which also powers auroral disturbance processes such as substorms and upper atmosphere heating. With current available PC indices, detailed and accurate SYM-H or Dst index values could be derived up to nearly one hour ahead of actual time by integration of the PCC-based source function from any previous quiet state. Thus, the PCC indices enabling accurate estimates of the energy input from the solar wind are powerful tools for space weather monitoring and for solar-terrestrial research.
Sonografie in der Rheumatologie – Update 2020
Authors: Ohrndorf Sarah
Published: December 2020

Die muskuloskelettale Sonografie ist ein bereits seit vielen Jahren etabliertes Verfahren in der Rheumatologie zur Diagnostik und Verlaufskontrolle von entzündlich rheumatischen Gelenkerkrankungen. Die sonografisch detektierte Synovitis hat eine prognostische Bedeutung sowohl in der Vorhersage einer Arthritis bei sogenannten Risikopatienten mit Arthralgien (ohne Gelenkschwellung) für die rheumatoide Arthritis („at risk for RA“), bei undifferenzierter Arthritis und dem bestehenden Verdacht auf RA sowie bei RA-Patienten in klinischer Remission zur Vorhersage einer radiografischen Progression bzw. eines Schubs. Bei der Psoriasis-Arthritis (PsA) ist die muskuloskelettale Sonografie vor allem hilfreich in der (frühen) Diagnostik, da bisher andere sogenannte Biomarker fehlen. Zusätzlich wird die Sonografie bei anderen rheumatologischen Systemerkrankungen, wie dem primären Sjögren-Syndrom zur Detektion von spezifischen Veränderungen der Speicheldrüsen sowie der Riesenzellarteriitis zur Entzündungsdetektion von Gefäßveränderungen insbesondere der A. temporalis und A. axillaris eingesetzt und hat damit einen bedeutenden Stellenwert in der rheumatologischen Diagnostik erlangt.