bluuebunny/crossref_metadata_2025 huggingface dataset:
Nörofizyoloji Laboratuvarına Düşük Ayak Tanısıyla Yönlendirilen Olguların Retrospektif Değerlendirilmesi
Authors: Aykaç Şeyma , Neşem Başkan Gülcan , Bademkıran Fikret , Uludağ Burhanettin , Çolakoğlu Zafer , Aydoğdu İbrahim
Published: September 2024

Amaç: Bu çalışmamızda düşük ayak ön tanısı düşünülerek nörofizyoloji laboratuvarına yönlendirilen olguların etiyolojik ve elektrofizyolojik özelliklerini ortaya koymayı amaçladık.
Gereç ve Yöntem: Ocak 2019 - Eylül 2022 arasında düşük ayak kliniği nedeniyle elektromiyografi (EMG) laboratuvarına yönlendirilen 127 olgunun klinik ve elektrofizyolojik bulguları retrospektif olarak değerlendirildi.
Bulgular: Çalışmaya dahil edilen 114 olgunun yaşları 18-85 (ort. 49,6) aralığında değişmekteydi. Olguların %31 i kadın, %69 u erkekti. 79 olgu dahili, 35 olgu ise cerrahi branşlardan yönlendirilmişti. Düşük ayak etiyolojisi olarak en sık fibuler sinir hasarı (%44.7) saptanmakla birlikte, sıklık sırasına göre radikülopati %21.9, siyatik sinir hasarı %16.7, polinöropati %10.5, lumbosakral pleksopati %4.4, ön boynuz motor nöron hastalığı %1,8 oranında saptanan diğer etiyolojilerdi. Olguların %83 ünde tek taraflı, %17 sinde bilateral düşük ayak mevcuttu. Bilateral düşük ayak saptanan 19 olgunun 12 sinde polinöropati, 3’ünde radikülopati (L4-5, S1 kök), 2’sinde fibula başı nöropatisi, 1’inde lumbosakral pleksopati, 1’inde ön boynuz motor nöron hastalığı mevcuttu. Elektrofizyolojik bulgular, olguların %85’inde aksonal, %11’inde demiyelinizan özellik göstermekteyken, %4 olguda demyelinizan veya aksonal hasar ayırdedilemedi. Fibular sinir hasarı dahili ve cerrahi branşlardan yönlendirilen olgularda en sık etiyolojik etken olmakla birlikte, dahili branşlarda polinöropati cerrahi branşlara göre daha sık saptandı. Tüm olgularda klinik olarak etkilenen bölge ile patolojik elektrofizyolojik bulguların elde edildiği bölge birbiri ile uyumluydu.
Sonuç: Düşük ayak kliniği ile yönlendirilen hastalarda etiyolojide fibular sinir nöropatisi sık olsa da, farklı etiyolojiler saptanabilir Elektrofizyolojik testler bu olgularda periferik patolojinin belirlenmesinde yol göstericidir. Bu nedenle düşük ayak kliniği olan olgularda lezyon lokalizasyonunun belirlenmesinde, etiyolojiye yönelik yapılması gereken tetkiklerin planlanmasında, nörolojik muayene ile birlikte elde edilen elektrofizyolojik bulgular mutlaka göz önünde bulundurulmalıdır.

Not: Bu çalışma 38.Ulusal Klinik Nörofizyoloji EEG-EMG Kongresi’nde (26-30 Ekim 2022) sözel bildiri şeklinde sunulmuştur.
An Unusual Complication In A Patient With Hodgkin Lymphoma: Bilateral Auricular Hematoma
Authors: Şahin Mustafa , Kamiloğlu Uğur , Kaya Ayşe , Miskioğlu Mine , Eskiizmir Görkem , Aydoğdu İsmet
Published: September 2024

Hodgkin lymphoma is lymphoid neoplasm in which the malignant cells admixed with a
heterogeneous population of non-neoplastic inflammatory cells. A combination of
Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine (ABVD) is the most commonly
used chemotherapy regime for Hodgkin lymphoma. In this case report, we present a
patient with Hodgkin lymphoma who developed bilateral auricular hematoma after a
first time administrition of ABVD treatment. A 27-year-old female patient was presented
to the hematology outpatient clinic with a swelling in the neck for two weeks. An
excisional biopsy performed from the left axillary region. The pathology report
demonstrated classical Hodgkin lymphoma was noticed to be consistent with mixed
cellular type. First dose ABVD protocol was administered to the patient. One week after
chemotherapy, swelling and discoloration were observed in the patient's bilateral
auricles without a history of trauma. The patient was consulted to the Department of
Otorhinolarngology-Head and Neck Surgery. Bilateral drainage of auricular hematoma
was performed immediately. Intravenous ciprofloxacin was also administered. The
auricular hematoma did not reoccur after the subsequent chemotherapy treatments.
İskemik inmeli hastalarda karotis intima-media kalınlığının vasküler risk faktörleri ile korelasyonu ve inme tipleri arasındaki dağılımı
Authors: Karaman Bedriye , Tunçel Rasim , Kumral Emre
Published: September 2024

Amaç: Nörolojik acillerin başında gelen, önemli bir mortalite ve morbidite nedeni olan iskemik inmeden korunmada altta yatan vasküler risk faktörlerinin ve etiyolojik inme tipinin belirlenmesi önem taşımaktadır. Bu çalışmada aterosklerozun erken bulgusu olan karotis intima-media kalınlık artışının iskemik inmeli hastalarda vasküler risk faktörleri ile korelasyonu ve inme tipi ile ilişkisini araştırmak amaçlanmıştır.
Gereç ve Yöntem: Çalışmaya iskemik inme nedenli takip edilmiş 40-90 yaş arası hastalar dahil edilmiş olup veriler hasta dosyalarından taranarak retrospektif olarak değerlendirilmiştir.
Bulgular: Çalışmaya 161 kadın, 112 erkek olmak üzere toplam 273 iskemik inmeli hasta dahil edildi. Karotis intima-media kalınlık artışının vasküler risk faktörleri ile korelasyonuna bakıldığında diyabet varlığı ile anlamlı ilişki saptanırken diğer risk faktörleri ile istatistiksel olarak anlamlı bir ilişki saptanmadı (p:0,03). İnme tipleri ile ilişkisi değerlendirildiğinde büyük arter aterosklerozuna bağlı inmelerde karotis intima-media kalınlık artışının anlamlı olarak daha fazla olduğu gösterildi.
Sonuç: Bu çalışmada karotis intima-media kalınlığının vasküler risk faktörleri ile birlikte değerlendirilmesinin inme etiyolojisini aydınlatmada ve dolayısıyla inmeden korunmada önemli katkısı olabileceği vurgulanmaktadır.
Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line
Authors: Kılıç Kubilay Doğan , Kayabaş Avşar Ayşenur , Özkanca Cemre , Sal Dila Hatun , Karabey Fatih , Yılmaz Zeynep Simge , Uyanıkgil Yiğit
Published: September 2024

Objective: The aim of this study was to investigate the cytotoxic effect of Helianthem germanicopolitanum Bornm., a rare endemic plant in Turkey, against colon cancer.
Materials and Methods: After the extraction of Helianthemum germanicopolitanum Bornm. plant, the phytochemical profile of the plant was analyzed by High Performance Liquid Chromatography (HPLC). Cytotoxicity analysis on HT-29 human colon cancer cell line was performed by WST 1 assay. The results were compared with other studies on similar plant species in the literature.
Results: H. germanicopolitanum plant contains various flavonoids and these flavonoids have cytotoxic effects on colorectal cancer cells. These cytotoxic effects provide anticarcinogenic effects by activating cell death pathways at certain concentrations. These findings provide an important insight into the therapeutic potential of the plant.
Conclusion: Cytotoxicity studies of flavonoids in extracts obtained from extraction procedures on colorectal cancer cell lines show that flavonoids offer anticarcinogenic effects by activating cell death pathways at certain concentrations.
Dietary Strategies to Reduce Atherosclerosis and Heart Attack Risk
Authors: Bilgin Murat , Soydan Elton , Dokuyucu Recep
Published: September 2024

The article delves into the significance of incorporating omega-3 fatty
acids, antioxidants, and fiber-rich foods into one's diet, all of which have been associated with a lower risk of atherosclerosis and heart attacks.
The Role of Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Mean Platelet Volume in Diagnosis of Hydrosalpinx
Authors: Atlıhan Ufuk , Bıldacı Tevfik Berk , Erkılınç Selçuk , Yavuz Onur , Avşar Hüseyin Aytuğ , Ata Can
Published: September 2024

Aim: It is very important to uncover the relationship between Hydrosalpinx, which occurs as a result of chronic-inflammatory-processes, and inflammatory markers. Our study aimed to investigate the role of Neutrophil/Lymphocyte Ratio(NLR), Platelet/Lymphocyte Ratio(PLR), and Mean Platelet Volume(MPV) values in the diagnosis of patients who had Hydrosalpinx.
Materials and Methods: Our study included 349 patients, who applied to our clinic between March 2018-June 2023, were diagnosed with primary or secondary infertility, and for this reason underwent Hysterosalpingography. A total of 89 patients who had Hydrosalpinx and 260 patients who did not have Hydrosalpinx were divided into 2 groups, and the demographic, clinical data were compared retrospectively.
Results: Neutrophil and Platelet levels were found to be significantly higher in the Hydrosalpinx-group than the control group(p:0.000).The presence of Hydrosalpinx was found to be significantly higher in patients who were diagnosed with secondary infertility(p:0.000).Neutrophil and Platelet levels were significantly higher in the bilateral-Hydrosalpinx-group than the unilateral-Hydrosalpinx-group(p:0.036,p:0.012, respectively). The NLR and PLR were found to be significantly higher in the bilateral-Hydrosalpinx-group than the unilateral–Hydrosalpinx-group(p:0.038,p:0.009, respectively). MPV were found to be significantly lower in the bilateral-Hydrosalpinx-group than the unilateral-Hydrosalpinx-group(p:0.011).
Conclusion: The findings of our study support the literature data on the relationship between NLR,PLR,MPV, and chronic inflammatory processes. These markers deserve to be evaluated again and again in prospective and controlled studies, in which they will be considered together with clinical findings, to investigate their ability to predict the diagnosis of Hydrosalpinx, its severity, and clinical outcomes in infertile patients.
Prevalence of metabolic syndrome patıents with systemic sclerosis
Authors: Özmen Ümit , Er Gülbezer Elif , Barutcuoğlu Burcu , Yargucu Zihni Figen
Published: September 2024

Objective: To determine the prevalence of metabolic syndrome (MetS) in Turkish systemic sclerosis (SSc) patients.
Materials and Methods: In this cross-sectional, single-centre study, 76 SSc patients admitted to the outpatient clinic of our tertiary care hospital between July and September 2021 were included. The National Cholesterol Education Programme's Adult Treatment Panel (NCEP-ATP III) criteria were used to define metabolic syndrome (MetS). The relationship between MetS and SSc organ involvement and disease characteristics was investigated.
Results: According to the ATP III criteria, 37 cases (48.7%) were identified as having MetS. The prevalance of MetS increased with advancing age (40-45 years: 25%, 46-60 years: 48.4%, >60 years: 62.9%). The cases were divided into two groups according to the presence or absence of MetS. Patients with MetS had higher mean age (58.2±9.4 vs. 51.6±13.5, p=0.015) and lower modified Rodnan skin scores (14 vs. 22, p=0.019). The groups were comparable regarding disease subtype, duration and activity, organs/systems involved and disease-related damage.
Conclusion: Although the prevalence of MetS in SSc patients in our study was higher than that observed in the general population of our country, the prevalence of MetS did not increase when compared to the similar age group. MetS was thought to be related to age and gender predominance rather than the disease itself. Although mRSS was found to be significantly lower in patients with MetS, its sensitivity to predict MetS was found to be low. Nevertheless, our data suggest that the risk of MetS should be considered in SSc patients.
Réseau commercial d'achat des grumes pour placages et contreplaqués
Authors: Le Ray J.
Published: September 2024

L'auteur n'aborde le problème que pour les bois tropicaux. Il rappelle le cadre actuel de l'exploitation forestière outre-mer et définit le rôle de l'exportateur qui, soit achète la totalité de la production d'un parc à bois donné, soit n'achète que certaines essences ou qualités de bois correspondant à un secteur d'utilisation, et s'occupe en particulier des opérations de réception et de classement des bois et de la mise en place des lots conformément aux contrats. L'auteur indique ensuite brièvement le rôle du courtier et de l'importateur. Il examine ensuite divers aspects techniques du sujet, les opérations commerciales proprement dites telles que le classement des grumes, les densités commerciales et les frets, ainsi que le règlement des litiges.Le classement consiste à sélectionner les bois et à classer les différentes grumes à l'intérieur de la sélection effectuée. Les caractéristiques des sélections et des lots commerciaux sont ensuite définies conformément aux travaux de l'Association technique internationale des bois tropicaux.L'auteur rappelle qu'au Havre, depuis la seconde guerre mondiale, les ventes de bois de seconde qualité se sont développées, et la tendance actuelle est à la vente de lots commerciaux de moindre valeur que les lots de qualité marchande. A titre d'exemple, l'auteur retrace l'évolution des classements effectifs de l'Okoumé (Gaboonwood) au cours des dix dernières années, qui peut être considéré comme un bois typique. Ensuite, des précisions sont données sur les différentes étapes du classement des bois depuis leur sortie de la forêt jusqu'à leur livraison au destinataire.En conclusion, l'auteur énumère les procédures habituellement suivies en cas de litige et évoque les possibilités de calcul des ristournes.
Application Of Microbubble Technology To Increase Oxygen Content In The Aquaculture Of Tambaqui (Colossoma Macropomum)
Authors: Fitriadi Ren , Palupi Mustika
Published: September 2024

The oxygen consumed is used to oxidize food substances to produce energy. Therefore, the metabolic rate is usually indicated by the rate of oxygen consumption per time unit. In most intensive aquaculture systems, oxygen content is widely used due to the high stocking density and maximum feeding rates. This study aimed to evaluate the growth performance of freshwater pomfret (Colossoma macropomum) treated with increased oxygen in two different systems. The study was conducted in a laboratory scale by applying T-test data analysis. The difference of treatment level applied in the comparison of aeration and microbubble consists of two treatments and three replications. The researcher used commercial floating pellets PF0 with 25% protein content, the feeding rate was 5% of the biomass. The feed was given daily during the culture for two times a day. Data of the study were analyzed using T-test on the Statistical Product and Service Solutions (SPSS) software Version 17.0. Results of the study showed that aeration system using microbubble resulted in dissolved oxygen (DO) of 6.5 ± 0.17, 100% pomfret fish survival rate (SR), Survival Growth Rate (SGR) of 1.83 ± 0.24, Feed Conversion Ratio (FCR) of 1.37 ± 0.17, Protein Efficiency Ratio (PER) of 2.79 ± 0.37, Feed Utilization Efficiency (FUE) of 0.67 ± 0.09, Absolute Weight Growth of 52.02 ± 1.60; it was better than using aeration. This study has developed a model of freshwater pomfret fish aquaculture to provide growth value.
Impact of the Color of Rearing Tank on Behavior and Growth of Nile Tilapia, Oreochromis niloticus (Linnaeus, 1758)
Authors: Ariyomo Tolulope Omolayo , Omobepade Bayode Paul , Adedeji Damilola B. , Olasunkanmi John Bunmi , Fabusoro Abiola Ayodeji , Jimoh Jeremiah Olanipekun , Tope-Jegede Oluwatosin Helen , Kelau Shedrach Joel
Published: September 2024

This study examined the impact of tank color (black, red, blue, green, and transparent) on the behavior (boldness and aggressiveness) and growth of Nile Tilapia over nine weeks (first, third, sixth, and ninth weeks). Boldness and aggression levels were assessed using open field and mirror image tests, respectively, for individual Nile Tilapia (Oreochromis niloticus). Healthy Nile Tilapia, initially weighing 2.51g on average, were used in the experimental trials conducted in tanks of different colors. The findings indicated that red tanks appeared to foster the highest level of boldness (p<0.05), whereas fish in transparent tanks exhibited the highest level of aggressiveness compared to other tanks (p<0.05). Moreover, individuals in black tanks displayed the highest growth rate in terms of weight (p<0.05). This study suggests that Oreochromis niloticus can thrive better in black-rearing tanks, as the black tanks appear to enhance the growth rate of the fish, possibly through improvements in physiological processes.
Potential of Antioxidant Activity Caulerpa racemosa Extract Using DES Solvent and Different Sonication Times as An Antibacterial Against Pathogenic Bacteria
Authors: Satyantini Woro Hastuti , Mukti Akhmad Taufiq , Bakhri Saiful
Published: September 2024

Caulerpa racemosa, a type of green algae, has been studied  for its potential health benefits, including antioxidant and an- tibacterial properties. The extraction of bioactive compounds  from marine algae using green solvents like Deep Eutectic Sol- vents (DES) has gained interest due to their efficiency and en- vironmental friendliness. This research aimed to determine  the potential antioxidant activity of C. racemosa extract using DES solvents and different sonication times as an antibacterial  against pathogenic bacteria. The research employed a Facto- rial Completely Randomized Design (CRD) with two variables:  sonication time (10, 20, and 30 minutes) and different DES solvents (ethanol and ethylene glycol (1:20) with 90% aquades, and methanol and glycerol (1:10) with 90% aquades. The highest antioxidant activity was found in DES  Methanol-Glycerol (36.39 mg TE/g dw), followed by DES Eth- anol-Ethylene glycol (28.30 mg TE/g dw), both significantly  different (p<0.05). The C. racemosa extract inhibited the growth of V. parahaemolyticus with an inhibition zone of 8.08 mm at 50 ppm and 13.13 mm at 1,000 ppm. For V. harveyi, inhibition started at 6.37 mm at 50 ppm, reaching 11.70 mm  at 1,000 ppm. DES Methanol-Glycerol with a 10-minute soni- cation provided the highest antioxidant activity and effectively  inhibited V. parahaemolyticus and V. harveyi. Extraction of C. racemosa with DES-MG solvent and varying sonication times influences its antioxidant activity and antibacterial properties.
New Records of the Egg Development Phase of Varuna litterata in the Lower Serayu River, Central Java
Authors: Sinaga Sorbakti , Widodo Maheno Sri , Maimunah Yunita
Published: September 2024

One of the Brachyura crabs found in the lower reaches of the Serayu River is Varuna litterata, also known as the "herring bow crab". This crab usually inhabits shallow tidal areas and hides under rocks, logs, or dead leaves. It is a highly adapted crab found in a wide range of salinities. V. litterata is also a fishery product consumed in Thailand, the Philippines, and Indonesia. This research was conducted in the Lower Serayu River, Central Java, which consists of three observation stations, namely: 1) the first station is located above the dam with fresh water, 2) the second station is below the dam with fresh water properties and 3) the third station is downstream (estuary) of the Serayu River with brackish water. This research was conducted for four months, from October 2023 to January 2024. This study aimed to determine the level of egg development in V. litterata. The results showed that V. litterata experienced four stages in egg development and then hatched into zoea. At the initial development stage, V. litterata eggs will be purple; in the second stage, the eggs will turn reddish; in the third development stage, the eggs will turn orange to brownish; and in the fourth stage, the eggs will develop and become black. V. litterata that will spawn will migrate to brackish waters to hatch their eggs. V. litterata produces 20,708 - 85,886 eggs with an average egg diameter of 0.440 - 0.466 mm.
Financial Performance Measurement Using the Value Added Method to Determine the Effect on Stock Prices
Authors: Ichsani Sakina , Pratiwi Leni Nur , Saputera Denny
Published: September 2024

One of the Indonesian government's policies since 2015 has been to increase development through its developed infrastructure, by increasing its budget for this sector from year to year. However, companies listed in the engineering and construction subsector on the Indonesian Stock Exchange, both state-owned enterprises and private companies, experienced losses so it could be said that their financial performance was poor. This study intends to evaluate the financial performance engineering and construction sub-sector companies using the Economic Value Added (EVA), Market Value Added (MVA), Refined Economic Value Added (REVA), Financial Value Added (FVA), and Shareholder Value Added (SVA) in 2018 – 2023 and determine their influence on stock prices. This type of research is quantitative descriptive research using E-Views 12 with a population 26 companies and a sample size 16 companies. Based on the results the calculations and analysis, it stated that EVA, MVA, REVA, FVA, SVA and stock prices engineering and construction companies, both state-owned and private, during the 2018 - 2023 period obtained an average of negative amounts. The research results show that the financial performance variables using value added have an influence on stock prices with influence of 74.57% while the rest is influenced by other variables not examined in this research. Partially only MVA and SVA have an influence on stock prices because based on the probability test using E-Views 12 it appears that only MVA and SVA produce results below the alpha. The suggestion for this research is that company management should pay attention to the company's financial performance, especially the MVA and SVA variables and further researcher can make comparative research between all value-added variables.
TEACHER MULTILINGUAL BELIEFS AND PRACTICES IN THE ENGLISH CLASSROOM: IMPLICATIONS FOR COURSE DEVELOPMENT
Authors: Osidak Viktoriia , Natsiuk Maryana , Vogt Karin
Published: September 2024

The CEFR and the Companion Volume to the CEFR (Council of Europe, 2001, 2020), as the main language policy documents in Europe, intend to improve the standard of language teaching, learning and assessment. These documents among other things proclaim students’ diverse linguistic repertoire as an asset in the language classroom. In this light, the promotion of multilingual education initiatives and enhancing students’ plurilingualism is an educational requirement. Teachers, language teachers included, are seen as agents of change who can foster multilingual approaches in their language classrooms (Krulatz et al., 2022). Although previous studies have found that many language teachers hold favourable views on multilingualism, they face challenges when implementing multilingual approaches in the (foreign) language classroom. Teachers’ beliefs on multilingualism in (foreign) language teaching and learning and how these impact their teaching practices have not been investigated in the Ukrainian education context, which has always been multilingual. The purpose of the article is to share and discuss the results of a quantitative study designed to investigate Ukrainian teacher beliefs in learning English and whether these beliefs are reflected in teaching practices. Data were collected using an online questionnaire administered to 73 English as a foreign language (EFL) teachers from 12 Ukrainian universities. The research questions were ascertained using descriptive statistics and Pearson correlation analysis. The collected insights helped to identify areas that require a more careful consideration in the multilingual education in Ukraine. The outcomes reveal complex and uneven relationships between teacher multilingual beliefs and the implementation of multilingual practices in EFL classrooms in Ukraine, with discrepancies in their perceptions and practices. The main finding suggests that the majority of Ukrainian language teachers have a favorable perception of multilingualism, yet they lack the required expertise and confidence to effectively build on their students' linguistic resources in teaching English. In addition, there are some critical gaps in teacher understanding of fundamental concerns about multilingualism. Suggestions will be made for a scenario-based approach to a teacher professional development course.
ONLINE FOREIGN LANGUAGE LEARNING BASED ON TELECOLLABORATIVE TASKS AND PROJECTS
Authors: Casañ-Pitarch Ricardo , Candel-Mora Miguel Ángel , Demydenko Olha , Kornieva Zoia
Published: September 2024

The development of new forms of technology has resulted in new methodologies and approaches in pedagogical practices, particularly within the field of foreign language education. This is especially useful in foreign language teaching because it allows students geographically distant to interact remotely. Moreover, the integration of task-based and project-oriented approaches implies a substantial increase in the quality and volume of communicative exchanges in virtual learning environments. This study aims to undertake a comparative analysis of two distinct online groups engaged in the same English B2 level course, although with different pedagogical strategies. While one group engages in collaborative, communicative tasks and a collective project, the other focuses on the individual completion of exercises and drills. Pre- and post-tests were administered to participants of both groups to gauge their linguistic progression. The findings reveal that the group involved in interactive tasks and collaborative projects demonstrated superior advancements in language proficiency. Furthermore, these participants reported an enhanced sense of confidence in their communicative competencies within professional contexts. The study concludes that integrating project-based learning and telecollaborative practices holds considerable potential to enhance the efficacy of foreign language instruction.
Triple Therapy De-escalation and Withdrawal of Inhaled Corticosteroid to Dual Bronchodilator Therapy in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis
Authors: Pirera Edoardo , Di Raimondo Domenico , Tuttolomondo Antonino
Published: September 2024

Background/Objectives: interpretation of evidence on de-escalation of triple therapy with with-drawal of inhaled corticosteroids (ICS) to dual bronchodilator therapy with a long-acting musca-rinic antagonist (LAMA) and a long-acting beta-agonist (LABA) in patients with chronic obstruc-tive pulmonary disease (COPD) is conflicting. We evaluated the efficacy and safety of ICS discon-tinuation from LABA-LAMA-ICS triple therapy compared to its continuation. Methods: we searched PubMed, Embase, Scopus, Web Of Science, clinicaltrial.gov and CENTRAL for RCTs and observational studies from inception to March 22, 2024, investigating the effect of triple therapy de-escalation with withdrawal of ICS to dual therapy on the risk of COPD exacerbation, pneumonia and lung function. This study was registered with PROSPERO, CRD42024527942. Results: 3335 studies were screened; three RCTs and three real-world non-interventional studies were ultimately identified as eligible. Analysis of the time to the first moderate or severe exacerbation showed a pooled HR of 0.96 (95% CI, 0.80 to 1.15; I²=77%) for ICS withdrawal compared with triple therapy continuation. Analysis according eosinophil levels showed that COPD subjects with ≥300 eosino-phils/µL had a significant increase in the incidence of moderate or severe exacerbations when de-escalated from ICS/LABA/LAMA to LABA/LAMA (pooled HR: 1.35, 95% CI 1.00-1.82; I2: 56%). The ICS withdrawal in favour of LABA/LAMA did not significantly affect the risk of mortality and pneumonia. Conclusions: the main findings of this meta-analysis are consistent with current recommendations and suggest that the use of eosinophil counts may be of help in guiding maintenance therapy. However, methodological heterogeneity between the included studies is evident.
Sulfur-Based Energy Storage Technologies
Authors: Ali Syed Adnan
Published: September 2024

The increasing global demand for efficient and sustainable energy storage solutions has driven the exploration of sulfur-based battery technologies. Sulfur’s abundance, low cost, and high theoretical energy density make it a promising candidate for next-generation energy storage, particularly in electric vehicles (EVs) and renewable energy systems. This paper reviews the development of sulfur-based batteries, including lithium-sulfur (Li-S), sodium-sulfur (Na-S), magnesium-sulfur (Mg-S), solid-state sulfur, sulfur-carbon nanocomposites, and hybrid sulfur flow batteries. Each technology is analyzed based on its advantages, challenges, and potential applications. Key research areas such as advanced electrolytes, nanomaterial integration, and sustainable manufacturing are highlighted, along with the current technological barriers to large-scale adoption. This review underscores the importance of continued research and innovation in sulfur-based battery technology to meet future energy storage demands.
Synthesis of methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates
Authors: Pilotzi Xahuentitla Hugo , Ortega Montes Jesús Guadalupe , Gnecco Medina Dino Hernán , Terán Vazquez Joel Luis , Hernández Núñez Emanuel , Orea Flores Maria Laura
Published: September 2024

Chiral oxazolidine moiety is an important core in asymmetric synthesis due to its ability to participate in various stereoselective chemical reactions and because forms a part of more complex important active compounds. Therefore, in this letter we report a convenient diastereoselective and practical strategy for the synthesis of chiral methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates starting from (R)-(–)-2-phenylglycinol and methyl propiolate which were obtained via simple two chemical and stereoselective reactions.
Zebra_K, a Kinematic Analysis Automated Platform for Assessing Sensitivity, Habituation and Prepulse Inhibition of the Acoustic Startle Response in Adult Zebrafish
Authors: Stevanovic Marija , Tagkalidou Niki , Multisanti Cristiana Roberta , Pujol Sergi , Aljabasini Ouwais , Prats Eva , Faggio Caterina , M. Porta Josep , Raldúa Demetrio
Published: September 2024

The acoustic startle response (ASR) is an explosive motor response leaded by a sudden and intense acoustic stimulus. ASR has several clinically relevant forms of plasticity, including habituation and sensorimotor gating. Although ASR and its plasticity have been intensively studied in different animal models, including zebrafish (Danio rerio) larvae, information in adult zebrafish is still very scarce. In this manuscript we present Zebra_K, a new automated high-content kinematic analysis platform for assessing ASR, its habituation and prepulse inhibition (PPI), a quantitative measure of sensorimotor gating, in adult zebrafish. The analysis of the kinematic parameters in 1,875 ASR in adult zebrafish has shown a single response wave consistent with the short-latency C-bend described in zebrafish larvae. Moreover, protocols have been designed and validated in Zebra_K for the analysis of sensitivity, habituation and PPI of this response. Then, this platform has been used to determine the effect of pharmacological and physiological modulators of ASR plasticity. As described in other animal models, the NMDA-receptor antagonist ketamine increased the responsiveness to the acoustic stimuli, decreasing habituation and leading to complete abolition of PPI. Moreover, the effect of the gender on zebrafish ASR plasticity has been analyzed for the first time. Females exhibited higher responsiveness and a lower habituation and PPI than males, a result consistent with the gender effect described in other animal models and in humans. These results enhance the interest of using adult zebrafish to assess the potential effect of chemicals or genetic manipulations on ASR plasticity.
Evaluation of a Portable Handheld Heterochromatic Flicker Photometer in Measuring Macular Pigment Optical Density
Authors: Davey Pinakin Gunvant , Rosen Richard B , Park Joshua , Spors Frank , Gierhart Dennis L
Published: September 2024

Macular pigment optical density (MPOD) is an important clinical biomarker for ocular conditions like macular degeneration, diabetic eye disease, and digital eye strain. Additionally, its measurements can be essential in health assessment for visual function, systemic diseases, and brain health. We aimed to assess the repeatability, agreement, and effects of the learning curve of the new portable handheld heterochromatic flicker photometer, Zx Pro, in measuring MPOD in a wide age range of ocular-healthy adults, compared to the MPOD measurements obtained using the clinically available QuantifEye device. Seventy-six participants performed one practice at-tempt and two study-related MPOD measurements with the Zx Pro and the QuantifEye. The Pearson correlation between the study-related MPOD measurements for Zx Pro and QuantifEye devices was 90% and 85%, respectively. Altman and Bland plots show excellent agreement between the device's MPOD data, with 95% limits of an agreement being -0.10 to +0.11 du. The mean difference between the practice attempt and the study-related measurements was not statistically significant for Zx Pro but was significant for QuantifEye (Repeated measures ANOVA p=0.325 and p=0.015, respectively). The Zx Pro provides excellent repeatable MPOD measurements, has an insignificant learning curve, and is in good agreement with the predicate device.
Molecular Sensomics Combined with Random Forest Model to Reveal the Evolution on Flavor Type of Baijiu Based on Differential Markers
Authors: Huang He , Chen Yiyuan , Hou Yaxin , Hong Jiaxin , Chen Hao , Zhao Dongrui , Wu Jihong , Li Jinchen , Sun Jinyuan , Sun Xiaotao , Huang Mingquan , Sun Baoguo
Published: September 2024

Baijiu is popular with its long history and balanced flavor, and flavor type was the most widely used classification mode for Baijiu. However, the evolution relationship of Baijiu flavor types and the differential markers between flavor types are still unclear, which has greatly affected the development of Baijiu industry. In this study, a total of 319 trace components were identified by gas chromatography-olfactometry-mass spectrometry and gas chromatography-mass spectrometry. Among them, 91 trace components with high odor active values or taste active values were recognized as flavor components. Then random forests were conducted to screen differential markers between derived and basic flavor types, and principal component analysis was carried out to evaluate their effectiveness in distinguishing the flavor types of Baijiu. Finally, 19 differential markers were screened and proved to effectively reveal the evolution Baijiu flavor types, and were further verified as key differential markers by addition test and correlation analysis.
Features of differential diagnosis of carbohydrate and fatty acid metabolism disorders in children
Authors:   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Sadovnikova I.V. , Abramov S.A. ,   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Egorskaуa A.T. ,   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Kisurina A.S. ,   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Khavkin A.I. ,   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region, Moscow, Russian Federation,   Belgorod State National Research University, Belgorod, Russian Federation
Published: September 2024

The purpose of presenting clinical observations is to demonstrate the differential diagnosis of metabolic diseases using clinical cases of carbohydrate and fat metabolism disorders as examples. Main points. Patient observation, analysis of the case histories of two patients with Hirke's disease and long-chain acyl-CoA fatty acid dehydrogenase deficiency, LCHADD, OMIM#609016). Patients aged 5 and 10 months were admitted to the clinic in a severe condition due to the lack of effect of outpatient treatment. Both children had hepatomegaly, with fibrosis stage F-0 according to METAVIR. In Hirke's disease there were diffuse changes in the liver, increased size of the kidneys, changes in their parenchyma, in the case of fat metabolism pathology the liver echostructure was homogeneous and uniform. The girl had diffuse repolarization abnormalities on ECG, the boy had delayed conduction along the right Giss bundle. Neurosonography showed residual posthypoxic changes in the girl (history of cerebral edema at the onset of the disease, sepsis, infectious-toxic shock, glycogenosis type 1a), venous dyscirculation. Both children's condition was stable and severe in the course of treatment. Conclusion. Peculiarities of the diseases caused by metabolic disorders are polymorphism of clinical manifestations, which causes difficulties of diagnostic search as well as timely selection of effective therapy. Key words: Hirke's disease, deficiency of long-chain 3-hydroxy acyl-CoA fatty acid dehydrogenase
Clinical observation of recurrent urinary tract infection in primary hyperparathyroidism
Authors:   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Zastelo E.S. , Bydanov N.M. ,   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Fedulova E.N. ,   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Skochilova T.V. ,   Privolzhsky Research Medical University, Nizhniy Novgorod, Russian Federation, Khavkin A.I. ,   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region, Moscow, Russian Federation
Published: September 2024

The article presents the medical history of a teenage girl with a recurrent urinary tract infection that occurred against the background of primary hyperparathyroidism. A feature of the clinical observation is a diagnostic search performed by a doctor in order to determine the factor leading to the recurrence of infection. The first clinical manifestation of the disease was frequent and painful urination, with complaints of which the patient came to an outpatient appointment with a nephrologist. Despite the correctly selected therapy in accordance with national clinical guidelines, there were relapses of infection confirmed clinically and laboratory. After the detection of hypercalciuria in combination with hypercalcemia, the patient was suspected of having hyperparathyroidism, which was subsequently proved by laboratory data. It is known from the catamnesis data that the performed surgical treatment led to a complete relief of the symptoms of the disease. This observation proves the variety of causes of recurrent urinary tract infection, which differ depending on the age and sex of the child, which leads to difficulties in making a correct diagnosis. Key words: hypercalciuria, hyperparathyroidism, urinary tract infection, parathyroid hormone
Physiological basis of body detoxification and the role of detox diets
Authors:   Novokuznetsk State Institute of Advanced Medical Training, Branch of the Russian Medical Academy of Continuous Professional Education, Novokuznetsk, Russian Federation, Lobykina E.N. , Lobykina A.A. ,   Kemerovo State Medical University, Kemerovo, Russian Federation
Published: September 2024

The idea of alternative medicine which aims to rid the body of toxins, i.e. “alternative detox”, is not new, extremely popular, and diverse. This article presents the result of a systematic review of 100 scientific literary sources on the use of detox diets in population health improvement. Literature review has shown that traditional natural detoxification, which the body copes with on its own, creates preconditions for the development of a new direction of therapy, a personalized detox diet. This is due to the current dramatic increase in exposure of the organism and excretory organs to various xenobiotics. Information is being accumulated about chemicals that place a certain burden on the body and various dietary options and individual food substances that can eliminate this burden. The currently known advantages and disadvantages of detox diets will help physicians properly evaluate them for health concerns. The various detox diets used as detoxification often carry a commercial orientation and require health authorities to monitor their safety. Further development of this therapeutic direction will allow not only to elaborate methods of diagnosis of toxins and ways of application of detox diets in different diseases, but also to correctly estimate their efficacy for wider introduction into the practice of physical and rehabilitation medicine and sanatorium resort treatment. Key words: detoxification, detox diets, detox programs, recovery, rehabilitation
Intestinal microbiota and microRNA in inflammatory bowel diseases: review of current data and future research prospects
Authors:   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation, Khavkin A.I. ,   Belgorod State University, Belgorod, Russian Federation, Nalyotov A.V. ,   M.Gorky Donetsk State Medical University, Donetsk, Russian Federation, Marchenko N.A. ,   M.Gorky Donetsk State Medical University, Donetsk, Russian Federation
Published: September 2024

Inflammatory bowel diseases include Crohn's disease and ulcerative colitis and are chronic diseases of the gastrointestinal tract characterized by hyperactive and unregulated immune responses in response to environmental factors, including intestinal microbiota and food components. An imbalance of the gut microbiota can contribute to the development and/or aggravation of the inflammatory process. microRNAs are associated with cell development and proliferation, apoptosis, and oncological processes. It has been proven that they play an important role in inflammatory processes in the intestine. Differences in microRNAs can be a useful tool in the diagnosis of inflammatory bowel diseases, as well as serve as a prognostic marker for this pathology. The relationship between microRNA and the intestinal microbiota has not been fully studied, but recently this topic has become very popular and has become the goal of a number of studies demonstrating the role of microRNA in the modulation of the intestinal microbiota and the induction of intestinal dysbiosis. The microbiota, in turn, can regulate microRNA expression and, consequently, alter intestinal homeostasis. This review is aimed at describing the interactions between the intestinal microbiota and microRNA in inflammatory bowel diseases, based on the results of modern research. Key words: inflammatory bowel diseases, intestinal microbiota, microRNA, dysbiosis, ulcerative colitis, Crohn's disease
Sistem Biometrik Pengenalan Wajah dengan Metode Grey Level Co-Occurrence Matrix dan Support Vector Machine
Authors: Bhakti Adhitiyah Redaya Kusuma , Riski Abduh , Kamsyakawuni Ahmad
Published: September 2024

Abstrak

Teknologi biometrik wajah dikembangkan untuk mengenali seseorang secara unik. Pada penelitian ini biometrik diaplikasikan pada aplikasi pengenalan wajah dengan citra wajah manusia sebagai objeknya menggunakan metode Grey Level Co-Occurrence Matrix dan Support Vector Machine. Metode GLCM merupakan metode yang digunakan untuk proses ekstraksi fitur citra. Sedangkan SVM digunakan untuk proses pengenalan/identifikasi. Tujuan dari penelitian ini adalah mendapat hasil akurasi yang baik untuk pengenalan wajah melalui kedua metode yang digunakan. Hasil yang diperoleh dari penelitian ini adalah akurasi pada data pelatihan sebesar 93% dengan total 200 citra wajah. Sedangkan pada data pengujian diperoleh akurasi sebesar 90% untuk 50 citra wajah.

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Abstract

Facial biometric technology was developed to uniquely recognize a person. In this research, biometrics was applied to face recognition applications with human face images as objects using the Gray Level Co-Occurrence Matrix and Support Vector Machine methods. The GLCM is a method used for the image feature extraction process. While SVM is used for the identification process. The purpose of this research is to get good accuracy results for face recognition through the two methods used. The results obtained from this research are the accuracy of the training data by 93% with a total of 200 face images. While the test data obtained an accuracy of 90% for 50 face images.
Pengembangan Alat Monitorisasi Biaya Penggunaan Debit Air PDAM Berbasis NodeMCU Menggunakan Bot Telegram
Authors: Supriyanto Hafizh Hanan , Susanto Rudi , Lestari Wiji
Published: September 2024

Abstrak 

Peningkatan efisiensi dalam pengelolaan sumber daya air merupakan salah satu aspek penting dalam industri penyediaan air bersih. Dalam hal ini, teknologi Internet of Things (IoT) dapat memainkan peran yang signifikan dengan memungkinkan penggunaan sensor dan perangkat terhubung untuk mengumpulkan data secara real-time dan mengirimkannya melalui jaringan internet. Dalam konteks ini, jurnal ini mempresentasikan pengembangan sebuah alat monitorisasi biaya penggunaan debit air PDAM berbasis NodeMCU yang terhubung dengan Bot Telegram. NodeMCU digunakan untuk menghubungkan alat monitorisasi dengan sensor debit air dan mengirim data ke server melalui jaringan Wi-Fi. Data yang dikumpulkan mencakup penggunaan air secara real-time, dan biaya yang terkait.Hasil pengujian menunjukkan bahwa alat monitorisasi yang dikembangkan mampu mengumpulkan data penggunaan debit air secara akurat dan mengirimkannya ke Bot Telegram dengan keandalan yang tinggi. Pengguna dapat mengakses informasi penggunaan air dan biaya secara real-time, yang memungkinkan mereka untuk memantau konsumsi air mereka dengan lebih baik dan mengelola pengeluaran mereka secara efektif.

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Abstract

Increasing efficiency in the management of water resources is one of the important aspects in the clean water supply industry. In this regard, Internet of Things (IoT) technology can play a significant role by enabling the use of sensors and connected devices to collect data in real-time and send it over the internet network. In this context, this journal presents the development of a NodeMCU-based PDAM water usage cost monitoring tool that is connected to the Telegram Bot. The data collected includes water usage in real-time, and the associated costs. The test results show that the monitoring tool developed is able to collect water usage data accurately and send it to the Telegram Bot with high reliability. Users can access real-time water usage and cost information, enabling them to better monitor their water consumption and manage their expenses effectively.

 