bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient and tumor factors contributing to distant metastasis in well-differentiated thyroid cancer: A retrospective cohort study
Authors: Khan Usman , Al Afif Ayham , Aldaihani Abdullah , MacKay Colin , Rigby Matthew H. , Rajaraman Murali , Imran Syed Ali , Bullock Martin J. , Taylor S. Mark , Trites Jonathan R. B. , Hart Robert D.
Published: November 2020

Background

Distant metastasis in thyroid cancer significantly reduces survival in patients with well-differentiated thyroid carcinoma (WDTC). There is limited information available to clinicians regarding pathological features that confer a higher risk of distant metastasis (DM). This study aimed to identify patient and tumor factors that were associated with the development of DM over time in patients with WDTC.

Methods

A retrospective cohort analysis of patients with WDTC ( n = 584) at our institution was performed between 2007 and 2017. A total of 39 patients with DM and 529 patients with no DM (NDM) were included. Patient demographics, tumor characteristics and patient survival were compared between the DM and NDM groups using a univariate analysis. Multivariate Cox-proportional hazards model was used to evaluate the risk of developing distant metastasis over time. Kaplan-Meier analysis was used to compare survival between the DM and NDM groups.

Results

Distant metastasis had a substantial impact on disease-specific survival (DSS) at 5 and 10-years in the DM group; 71.0% (SE 8.4%) and 46.9% (SE 11.6%) respectively, compared to 100% survival in the NDM group ( p < 0.001). The DM group had significantly higher proportions of males, lymphovascular invasion (LVI), nodal metastasis (NM), large tumor size (TS), extrathyroidal extension (ETE), positive resection margins, multifocality, follicular thyroid cancer (FTC), tall cell variant of papillary thyroid cancer (PTC), and Hurthle cell carcinoma (HCC), when compared to the NDM group ( p < 0.05). A TS ≥ 2 cm (Hazard Ratio (HR) 1.370), NM (HR 3.806) and FTC (HR 7.068) were associated with a significantly increased hazard of developing distant metastasis in patients with WDTC.

Conclusions

TS ≥ 2 cm, NM and FTC are associated with a significantly increased propensity for developing DM in our cohort of WDTC patients.

Graphical Abstract
Surgical treatment of fourth branchial apparatus anomalies: A case series study
Authors: Li Wan-Xin , Dong Yanbo , Zhang Aobo , Tian Jun , Lu Cheng , Jeannon Jean Pierre , Liu Liangfa
Published: November 2020

Background

Fourth branchial apparatus anomalies, are rare clinical entities, and present as complex cysts, sinuses and fistulae in the neck that can be difficult to manage.

Methods

This is a retrospective review of a series of consecutive patients with fourth branchial apparatus anomalies treated at Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, from Apr 2014 to Nov 2019.

Results

Ten patients with fourth branchial apparatus anomalies were identified, including 8 patients with fourth branchial fistula, and 2 patients with fourth branchial pouch sinus. There were 6 female patients and 4 male patients. Their age was from 6 years old to 39 years old (average age 20.4 years old, median age was 21 years old). All 8 fistulae were on the left side, while 2 pouch sinuses were both on the right side. Pre-operative examination with fiberoptic laryngoscope, barium swallow X-ray, CT or MRI identified internal orifice at pyriform fossa apex in 8 (80%) patients. All patients underwent challenging surgical resection by the senior author. Intra-operative direct laryngoscope confirmed or identified internal orifice in 9 (90%) patients. The tracts were all followed to the vicinity of inferior cornu of the thyroid cartilage and the cricothyroid space. Complete resection of cervical lesions and their attachment to hypopharynx were achieved in 9 cases. No complication occurred. One recurrence was detected, in the only patient whose internal orifice could not be located pre- or intra-operatively, and the hypopharyngeal attachment could not be removed.

Conclusions

Direct laryngoscopy under general anesthesia is a reliable method of diagnosis for the fourth branchial apparatus anomalies. Complete surgical removal of fourth branchial apparatus anomalies, including their hypopharyngeal attachment, is the treatment of choice, and the key to prevent recurrence.
Comparison of sort algorithms in Hadoop and PCJ
Authors: Nowicki Marek
Published: November 2020

Sorting algorithms are among the most commonly used algorithms in computer science and modern software. Having efficient implementation of sorting is necessary for a wide spectrum of scientific applications. This paper describes the sorting algorithm written using the partitioned global address space (PGAS) model, implemented using the Parallel Computing in Java (PCJ) library. The iterative implementation description is used to outline the possible performance issues and provide means to resolve them. The key idea of the implementation is to have an efficient building block that can be easily integrated into many application codes. This paper also presents the performance comparison of the PCJ implementation with the MapReduce approach, using Apache HadoopTeraSortimplementation. The comparison serves to show that the performance of the implementation is good enough, as the PCJ implementation shows similar efficiency to the Hadoop implementation.
Specialist Coaching Integrated into a Department of Methodology in Team Sports Organisations
Authors: Otte Fabian W. , Rothwell Martyn , Woods Carl , Davids Keith
Published: November 2020

With increasing resources in sports organisations being allocated to the development and preparation of individual athletes and sub-groups with specialist performance roles, the work of coaches, specialist (role) coaches and support staff needs to be functionally and coherently integrated. This integration of sport science support and coaching can be administered by staff in a Department of Methodology (DoM). Particularly, in this paper, we propose how specialist coaching can be situated in a DoM, presenting a model advocating effective functioning in high-performance team sports organisations. Using principles of ecological dynamics, we provide a rationale for a functional methodology for the design of practice tasks in a DoM that views learners aswayfinders, self-regulating their way through competitive performance environments. This rationale for athlete self-regulation in practice could improve athlete performance by enhancing problem solving, engagement with constraints of learning designs and supporting better attunement to contextual information abundant in a competitive environment. Finally, by introducing this unified and multidisciplinary DoM, specialist coaches, team coaches and sport science support staff, within the organisational structure, can collaboratively debate and co-design individualised athlete training programmes to enrich skill adaptability and performance functionality. To underline these contentions, three high-performance sport case studies from Australian Football: goalkeeping in Association Football and Rugby League are presented.
Central pontine myelinolysis during treatment of hyperglycemic hyperosmolar syndrome: a case report
Authors: Kusumoto Koshi , Koriyama Nobuyuki , Kojima Nami , Ikeda Maki , Nishio Yoshihiko
Published: November 2020

Background

Central pontine myelinolysis (CPM) is a non-inflammatory demyelinating lesion of the pons. CPM and extrapontine demyelination (EPM) are together termed osmotic demyelination syndrome (ODS), a known and serious complication of acute correction of hyponatremia. Conversely, hyperglycemic hyperosmolarity syndrome (HHS) develops in patients with type 2 diabetes who still have some insulin secretory ability due to infection, non-compliance with treatment, drugs, and coexisting diseases, and is often accompanied by ketosis. HHS represents a life-threatening endocrine emergency (mortality rate, 10–50%) associated with marked hyperglycemia and severe dehydration. HHS may develop ODS, and some cases have been associated with hypernatremia.

Case presentation

The patient was an 87-year-old woman with hyperglycemia, dehydration, malnutrition, and potential thrombus formation during long-term bed rest. HHS was suspected to have developed due to progression of hyperglycemia and dehydration caused by pneumonia. Furthermore, ketoacidosis developed from ketosis and prerenal renal failure associated with circulating hypovolemia shock, which was also associated with disseminated intravascular coagulation. Treatment was started with continuous intravenous injection of fast-acting insulin and low-sodium replacement fluid. In addition, ceftriaxone sodium hydrate, heparin sodium, thrombomodulin α, human serum albumin, and dopamine hydrochloride were administered. Blood glucose, serum sodium, serum osmolality, and general condition (including vital, infection/inflammatory findings, and disseminated intravascular coagulation) improved promptly, but improvements in disturbance of consciousness were poor. Diffusion-weighted imaging of the brain 72 h after starting treatment showed no obvious abnormalities, but high-intensity signals in the midline of the pons became apparent 30 days later, leading to definitive diagnosis of CPM.

Conclusions

Fluctuation of osmotic pressure by treatment from hyperosmolarity due to hyperglycemia and hypernatremia in the presence of risk factors such as malnutrition, severe illness, and metabolic disorders may be a cause of CPM onset. When treating HHS with risk factors, the possibility of progression to ODS needs to be kept in mind.
Wielding a gun increases judgments of others as holding guns: a randomized controlled trial
Authors: Witt Jessica K. , Parnes Jamie E. , Tenhundfeld Nathan L.
Published: November 2020

The gun embodiment effect is the consequence caused by wielding a gun on judgments of whether others are also holding a gun. This effect could be responsible for real-world instances when police officers shoot an unarmed person because of the misperception that the person had a gun. The gun embodiment effect is an instance of embodied cognition for which a person’s tool-augmented body affects their judgments. The replication crisis in psychology has raised concern about embodied cognition effects in particular, and the issue of low statistical power applies to the original research on the gun embodiment effect. Thus, the first step was to conduct a high-powered replication. We found a significant gun embodiment effect in participants’ reaction times and in their proportion of correct responses, but not in signal detection measures of bias, as had been originally reported. To help prevent the gun embodiment effect from leading to fatal encounters, it would be useful to know whether individuals with certain traits are less prone to the effect and whether certain kinds of experiences help alleviate the effect. With the new and reliable measure of the gun embodiment effect, we tested for moderation by individual differences related to prior gun experience, attitudes, personality, and factors related to emotion regulation and impulsivity. Despite the variety of these measures, there was little evidence for moderation. The results were more consistent with the idea of the gun embodiment effect being a universal, fixed effect, than being a flexible, malleable effect.
Decreased admissions and change in arrival mode in patients with cerebrovascular events during the first surge of the COVID-19 pandemic
Authors: Hoyer Carolin , Weber Lenja , Sandikci Vesile , Ebert Anne , Platten Michael , Szabo Kristina
Published: November 2020

Background and purpose

Investigating clinical characteristics of patients presenting with cerebrovascular events during the pandemic may provide valuable insight into further understanding the phenomenon of decreased stroke admissions during the COVID-19 pandemic.

Method

Data of patients presenting with a cerebrovascular event to the emergency department during weeks 12–17/2020 were compared to data from the respective weeks in 2019.

Results

A significant reduction in the number of admissions by 35.9% (p = 0.005) was observed during the COVID-19 epoch. In addition, significantly more patients arrived by ambulance during the COVID-19 epoch (2019: 75.7%, 2020: 94.2%; p = 0.001).

Conclusion

Our data may have implications as to how campaigns raising awareness for serious medical conditions in the context of the pandemic should be framed.
Podophyllotoxin-polyacrylic acid conjugate micelles: improved anticancer efficacy against multidrug-resistant breast cancer
Authors: Kumbhar Popat S. , Sakate Asmita M. , Patil Onkar B. , Manjappa Arehalli S. , Disouza John I.
Published: November 2020

Background

Podophyllotoxin (PPT) is a naturally occurring compound obtained from the roots of Podophyllum species, indicated for a variety of malignant tumors such as breast, lung, and liver tumors. This toxic polyphenol (PPT) exhibited significant activity against P-glycoprotein (P-gp) mediated multidrug-resistant (MDR) cancer cells. However, extremely poor water solubility, a narrow therapeutic window, and high toxicity have greatly restricted the clinical uses of PPT. Therefore, the present research was aimed to synthesize the water-soluble ester prodrug of PPT with polyacrylic acid (PAA), a water-soluble polymer by Steglich esterification reaction, and to screen it for assay, solubility, in vitro hemolysis, in vitro release, and in vitro anticancer activity.

Results

The Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopy results revealed the successful synthesis of podophyllotoxin-polyacrylic acid conjugate (PPC). The assay and saturation solubility of the prodrug is found to be 64.01 ± 4.5% and 1.39 ± 0.05 mg/mL (PPT equivalent) respectively. The PPC showed CMC (critical micelle concentration) of 0.430 mg/mL in distilled water at room temperature. The PPC micelles showed a mean particle size of 215 ± 11 nm with polydispersity index (PDI) of 0.193 ± 0.006. Further, the transmission electron microscope (TEM) results confirmed the self-assembling character of PPC into micelles. The PPC caused significantly less hemolysis (18.6 ± 2.9%) than plain PPT solution. Also, it demonstrated significantly (p < 0.01) higher in vitro cytotoxicity against both sensitive as well as resistance human breast cancer cells (MCF-7 and MDA MB-231) after 48 h of treatment.

Conclusion

The obtained study results clearly revealed the notable in vitro anticancer activity of PPT following its esterification with PAA. However, further in vivo studies are needed to ascertain its efficacy against a variety of cancers.
Vitamin D receptor gene polymorphism and hepatocellular carcinoma in chronic hepatitis C patients
Authors: Mosaad Hala , Emam Emad A. , Hamed Emad F. , El Demerdash Ezzat A. , Hussein Samia
Published: November 2020

Background

Hepatocellular carcinoma (HCC) is a prevalent malignancy worldwide. Vitamin D receptor (VDR) gene polymorphisms were linked to different cancers. This study was carried out to assess the possible relation between VDR gene polymorphism and the occurrence of HCC in chronic hepatitis C patients. This study included 102 subjects classified into three groups. Group A included 34 healthy subjects as control. Group B included 34 chronic hepatitis C patients with HCC. Group C included 34 chronic hepatitis C patients without HCC. Estimation of Apa-1 VDR gene polymorphism was performed by restriction fragment length polymorphism-Polymerase chain reaction (RFLP-PCR).

Results

In HCC group, C allele was more frequent than A allele (80.88% and 19.12%), respectively. In chronic hepatitis group, C allele was more frequent than A allele (64.71% and 35.29%), respectively. In control group, A allele was more frequent than C allele (73.53% and 26.47%), respectively. Genotype CC + CA was dominant in HCC group (91.18%) and chronic hepatitis group (79.41%). In the control group, the dominant genotype was AA (58.82%). Moreover, there was a significant relation between Apa-1 VDR genotype CC and tumor size.

Conclusions

There is an association between VDR Apa-1 polymorphism and the occurrence of HCC in chronic hepatitis C patients.
Application of response surface methodology (RSM) in statistical optimization and pharmaceutical characterization of a patient compliance effervescent tablet formulation of an antiepileptic drug levetiracetam
Authors: Mahapatra Abikesh Prasada Kumar , Saraswat Rohit , Botre Mahesh , Paul Basudev , Prasad Neelkant
Published: November 2020

Background

The main objective of the present study was to develop and optimize an effervescent tablet of levetiracetam, an antiepileptic drug, using central composite design with response surface methodology (RSM).The present investigation helps to overcome the problem associated with levetiracetam tablets and liquid dosage forms with children and elderly people like bad taste and swallowing difficulties. It also facilitates as an alternative manufacturing process for advanced patented technology like 3D printing process employed in SPRITAM® tablet.

Levetiracetam effervescent tablets were prepared by dry granulation (roll compaction) method using water-soluble excipients and optimized by central composite rotatable design (CCRD) using two variables (citric acid and effersoda) at two levels (high and low). Overall, fourteen formulation trials were generated through statistical software Minitab 17.3.0 placing 6 center points, 4 cube points, and 4 axial points. All formulations were subjected to compression using single punch machine.

Results

Quality attributes of compressed tablets were evaluated using various compendial and non-compendial tests. RSM was used to observe the responses like effervescent time, hardness, and friability of the prepared tablet batches for different levels of all the variables. Polynomial equations were developed, and model plots (contour plot and 3-dimensional model surface plots) were generated to study the impact of acid-base couple on the responses. Finally, the optimized formulation was selected on the basis of desired effervescent time, hardness, friability, percent drug release, and drug content. From the studied RSM design, it was observed that small changes in the independent variables (citric acid and effersoda) correlate with shifts in the dependent variables, i.e., the desired responses. The study reveals that all the independent variables (citric acid and effersoda) and dependent variables (effervescent time, hardness, and friability) have a good correlation as indicated by good linear regression coefficient of 0.9808, 0.9939, and 0.9892 for effervescent time, hardness, and friability respectively.

Conclusion

Levetiracetam effervescent tablets are satisfactorily prepared by dry granulation (roll compaction) approach. All desired critical quality attributes were found to be satisfactory. The applicability of RSM with desirability function in optimizing the levetiracetam formulation has made it possible to identify the impact of various independent variables and explore their effect on required responses.
Homicide by men diagnosed with schizophrenia: national case–control study
Authors: Baird Alison , Webb Roger T. , Hunt Isabelle M. , Appleby Louis , Shaw Jenny
Published: November 2020

Background

Some people diagnosed with schizophrenia are more prone to committing acts of serious violence, especially in the presence of drug or alcohol misuse. The rarity of homicide has meant that no large controlled study has previously examined clinical risk factors.

Aims

To determine the risk factors for homicide by males diagnosed with schizophrenia.

Method

A national nested case–control study of all previously admitted males diagnosed with schizophrenia, convicted of homicide between 1 January 1997 and 31 December 2012. Univariate and multivariable conditional logistic regression models were fitted to identify predictors of homicide in this population.

Results

During the observation period 160 male patients with schizophrenia and a history of psychiatric admission were convicted of homicide, and they were matched with 542 male control patients who had not been convicted of homicide. Patients who committed homicide were more likely to have a history of violence and comorbid personality disorder or drug misuse. They were more likely to have missed their last contact with services prior to the offence and to have been non-adherent with their treatment plan. Almost all (94%) of homicides were committed by patients who had a history of alcohol or drug misuse and/or who were not in receipt of planned treatment.

Conclusions

In England and Wales, homicides by patients with schizophrenia without substance misuse and in receipt of planned care are exceptionally rare. To prevent serious violence, mental health services should focus on drug and alcohol misuse, treatment adherence and maintaining contact with services.
Intersection of Polycystic Ovary Syndrome and the Gut Microbiome
Authors: Rizk Maryan G , Thackray Varykina G
Published: November 2020

The etiology of polycystic ovary syndrome (PCOS) remains unclear, although studies indicate that both genetic and environmental factors contribute to the syndrome. In 2012, Tremellen and Pearce proposed the idea that dysbiosis of the intestinal (gut) microbiome is a causative factor of metabolic and reproductive manifestations of PCOS. In the past 5 years, studies in both humans and rodent models have demonstrated that changes in the taxonomic composition of gut bacteria are associated with PCOS. Studies have also clearly shown that these changes in gut microbiota are associated with PCOS as opposed to obesity, since these changes are observed in women with PCOS that are both of a normal weight or obese, as well as in adolescent girls with PCOS and obesity compared with body mass index- and age-matched females without the disorder. Additionally, studies in both women with PCOS and rodent models of PCOS demonstrated that hyperandrogenism is associated with gut microbial dysbiosis, indicating that androgens may modulate the gut microbial community in females. One study reported that the fecal microbiome transplantation of stool from women with PCOS or exposure to certain bacteria resulted in a PCOS-like phenotype in mice, while other studies showed that exposure to a healthy gut microbiome, pre/probiotics, or specific gut metabolites resulted in protection from developing PCOS-like traits in mice. Altogether, these results suggest that dysbiosis of the gut microbiome may be sufficient to develop PCOS-like symptoms and that modulation of the gut microbiome may be a potential therapeutic target for PCOS.
Counting Citizens in Assam
Authors: Barbora Sanjay
Published: November 2020

The current protests over the government of India’s Citizenship (Amendment) Act (CAA) constitute the most resolute civic resistance to efforts at transforming the country’s political landscape. The government’s need to tamper with the existing laws and procedures for granting citizenship had a contested beginning in Assam. Here, the country’s Supreme Court mandated the enumeration of citizens under the National Register of Citizens (NRC)—a process that was partially attempted in 1951—in order to address long-standing political demands for autonomy and self-determination. Following the contested process that left close to two million people outside the register, the ruling Bharatiya Janata Party (BJP) sought to introduce CAA, ostensibly to ensure that non-Muslims were not affected by exclusion in the NRC. This article focuses on the reasons why this has not resolved the issue of citizenship in Assam, adding instead more layers to the already contentious claims over resources and territory in India’s northeast.
Constitution-As-Commons
Authors: Kannabiran Kalpana
Published: November 2020

Extrapolating from the ideas of Elinor Ostrom and scholars of the commons, the conceptualization of the Constitution as a commons opens the Constitution out to radical, insurgent readings that redefine belonging and ownership—it is no longer the property of state legislatures and courts to (mis)interpret in the service of political expediency/judicial bias/equivocation. It is the people who, through collective action and civic engagement, hold institutions to account and provide the tools and experiences that must shape constitutional interpretation. This article will examine the emergence of the constitution-as-commons as the space for a public, shared, collectively crafted jurisprudence of citizenship, occupying the commons of the nation and the commons that the Constitution in fact is, bringing space and belonging together in unanticipated ways. What are the implications for courts and for the futures of the Constitution of the rupture of a sequestered “constitutional jurisprudence” through the articulation of an expansive, inclusive constitution-as-commons by “we, the people?”
CMV-encoded GPCR pUL33 activates CREB and facilitates its recruitment to the MIE locus for efficient viral reactivation
Authors: Krishna Benjamin A. , Wass Amanda B. , Dooley Abigail L. , O'Connor Christine M.
Published: November 2020

Human cytomegalovirus (HCMV) establishes life-long latent infection in hematopoietic progenitor cells and circulating monocytes in infected individuals. Myeloid differentiation coupled with immune dysregulation leads to viral reactivation, which can cause severe disease and mortality. Reactivation of latent virus requires chromatin reorganization and the removal of transcriptional repressors in exchange for transcriptional activators. While some factors involved in these processes are identified, a complete characterization of the viral and cellular factors involved in their upstream regulation remains elusive. Herein we show the HCMV-encoded G protein-coupled receptor (GPCR), UL33, is expressed during latency. While this viral GPCR is not required to maintain latent infection, our data reveal UL33-mediated signaling is important for efficient viral reactivation. Additionally, UL33 signaling induces cellular cAMP response element binding protein (CREB) phosphorylation, a transcription factor whose recruitment to the major immediate early (MIE) enhancer/promoter promotes reactivation. Finally, targeted pharmacological inhibition of CREB activity reverses the reactivation phenotype of the UL33 signaling deficient mutant. In sum, our data reveal UL33-mediated signaling functions to activate CREB, resulting in successful viral reactivation.
Developmental anomalies of the superior vena cava and its tributaries: What the radiologist needs to know?
Authors: Verma Mansi , Pandey Niraj Nirmal , Ojha Vineeta , Kumar Sanjeev , Ramakrishnan Sivasubramaniam
Published: November 2020

Deviations from the normal process of embryogenesis can result in various developmental anomalies of the superior vena cava (SVC). While these anomalies are often asymptomatic, they assume clinical importance during interventions such as central venous catheterisations and pacemaker implantations and during cardiothoracic surgeries while instituting cardiopulmonary bypass and for creation of cavo-pulmonary connections. Role of imaging in identifying these anomalies is indispensable. Cross-sectional imaging techniques like CT venography and magnetic resonance (MR) venography allow direct visualisation and consequently increased detection of anomalies. CT venography plays an important role in detection of SVC anomalies as it is readily available, has excellent spatial resolution, short acquisition times and potential for reconstruction of images in multiple planes. This pictorial review focuses on the developmental anomalies of the SVC and its tributaries highlighting their embryological basis, imaging appearances on CT venography and potential clinical implications, where relevant.
RNA partitioning into stress granules is based on the summation of multiple interactions
Authors: Matheny Tyler , Van Treeck Briana , Huynh Thao Ngoc , Parker Roy
Published: November 2020

Stress granules (SGs) are stress-induced RNA–protein assemblies formed from a complex transcriptome of untranslating ribonucleoproteins (RNPs). Although RNAs can be either enriched or depleted from SGs, the rules that dictate RNA partitioning into SGs are unknown. We demonstrate that the SG-enriched NORAD RNA is sufficient to enrich a reporter RNA within SGs through the combined effects of multiple elements. Moreover, artificial tethering of G3BP1, TIA1, or FMRP can target mRNAs into SGs in a dose-dependent manner with numerous interactions required for efficient SG partitioning, which suggests individual protein interactions have small effects on the SG partitioning of mRNPs. This is supported by the observation that the SG transcriptome is largely unchanged in cell lines lacking the abundant SG RNA-binding proteins G3BP1 and G3BP2. We suggest the targeting of RNPs into SGs is due to a summation of potential RNA–protein, protein–protein, and RNA–RNA interactions with no single interaction dominating RNP recruitment into SGs.
The ethics of data sharing and biobanking in health research
Authors: Bull Susan , Bhagwandin Niresh
Published: November 2020

The importance of data sharing and biobanking are increasingly being recognised in global health research. Such practices are perceived to have the potential to promote science by maximising the utility of data and samples. However, they also raise ethical challenges which can be exacerbated by existing disparities in power, infrastructure and capacity. The Global Forum on Bioethics in Research (GFBR) convened in Stellenbosch, South Africa in November 2018, to explore the ethics of data sharing and biobanking in health research. Ninety-five participants from 35 countries drew on case studies and their experiences with sharing in their discussion of issues relating to respecting research participants and communities, promoting equitable sharing, and international and national approaches to governing data sharing and biobanking. In this editorial we will briefly review insights relating to each of these three themes.
Comparison of Bending Strength among Plate, Steinmann Pin, and Headless Compression Screw Fixations for Proximal Ulnar Shaft Fracture in Sawbones
Authors: Han Jinyoung , Oh Jin Rok , Um Jaewoong
Published: November 2020

Purpose: Although plate osteosynthesis is commonly used to treat proximal ulna fracture, its treatment method is controversial because of complications such as large incision, long operation time, and soft tissue injury. Therefore, intramedullary headless compression screw (HCS) and Steinmann pin are considered as alternative treatment options. In this study, we aim to compare bending strength of plate and cortical screws, HCS, and Steinmann pin for proximal ulnar shaft fracture with sawbone. Methods: Transverse type fractures were made intentionally at the distal 7 cm from the proximal end of ulna sawbones and fixated with plate, HCS, and Steinmann pin after reduction. Three-point bending tests were performed with total of 21 sawbones, seven pieces for each group. Results: Average ultimate bending strength for each group was as follows; 521.7N for plate fixation group, 706.4N for HCS fixation group, and 812.6N for Steinmann pin fixation group. Statistically significant results were observed among the three groups (p<0.01). When two groups were compared separately, Steinmann pin fixation and plate fixation (p<0.01), Steinmann pin and HCS fixation (p=0.047) showed statistical significance. There was a significant trend between HCS and plate fixation group (p=0.064).Conclusion: HCS and Steinmann pin fixation showed higher bending strength when compared to plate fixation for proximal ulnar shaft fracture in sawbone. Although further studies are needed, HCS and Steinmann pin fixation are promising fixation methods that may be used as an alternative to plate fixation.
Cylindrical vector beams demultiplexing optical communication based on spin-dependent vortex Dammann grating
Authors: Zhang Huabin , Fu Chuanwen , Fang Juncheng , Lei Ting , Zhang Yilin , Yuan Xiaocong
Published: November 2020

The amount of information is increasing rapidly to reach the capacity limit of single mode fiber. Cylindrical vector beams (CVBs) as the eigenmodes of fiber have been demonstrated to increase the capacity in multiplexing optical communication. As a key component of CVB multiplexing, a sorter based on spin-dependent vortex Dammann grating has advantages of uniform power distribution and compact size. Here, we propose and demonstrate a spin-dependent vortex Dammann grating device that can realize the sorting of multiple CVBs. By a spin-dependent focusing lens, the spin components of the CVBs are selectively focused or derived; therefore, the coaxially incident CVBs are separated effectively. We also experimentally demonstrate the CVB demultiplexing communication enabled by the grating with low channel cross talk satisfying the communication requirement.
Single-molecule orientation localization microscopy II: a performance comparison
Authors: Zhang Oumeng , Lew Matthew D.
Published: November 2020

Various techniques have been developed to measure the 2D and 3D
positions and 2D and 3D orientations of fluorescent molecules with
improved precision over standard epifluorescence microscopes. Due to
the challenging signal-to-background ratio in typical single-molecule
experiments, it is essential to choose an imaging system optimized for
the specific target sample. In this work, we compare the performance
of multiple state-of-the-art and commonly used methods for orientation
localization microscopy against the fundamental limits of measurement
precision. Our analysis reveals optimal imaging methods for various
experiment conditions and sample geometries. Interestingly, simple
modifications to the standard fluorescence microscope exhibit superior
performance in many imaging scenarios.
Metal-free plasmonic refractory core-shell nanowires for tunable all-dielectric broadband perfect absorbers
Authors: Zhang Houjiao , Liu Zhengqi , Zhong Haozong , Liu Guiqiang , Liu Xiaoshan , Wang Junqiao
Published: November 2020

In this work, we numerically demonstrate a new facile strategy for all-dielectric broadband optical perfect absorbers. A monolayer refractory titanium oxide and nitride (TiN/TiO2) core-shell nanowires array is used to form the grating on the opaque TiN substrate. Multiple resonant absorption bands are observed in the adjacent wavelength range, which therefore leads to the formation of an ultra-broadband absorption window from the visible to the infrared regime. The maximal absorption reaches 95.6% and the average absorption efficiency in the whole range (0.5–1.8 µm) is up to 85.4%. Moreover, the absorption bandwidth can be feasibly adjusted while the absorption efficiency can be still maintained in a high level via tuning the polarization state. Furthermore, the absorption window is observed to be highly adjustable in the wavelength range, showing a nearly linear relationship to the shell's index. These features not only confirm the achievement of the broadband perfect absorption but also introduce feasible ways to artificially manipulate the absorption properties, which will hold wide applications in metal-free plasmonic optoelectronic devices such as the solar harvesting, photo-detection, and thermal generation and its related bio-medical techniques.
Manipulation of femtosecond laser filamentation by a gaseous lattice
Authors: Guo Yajun , Wang Jianji , Lin Jingquan
Published: November 2020

Manipulation of femtosecond laser filamentation is essential for many potential applications. We report the simulations of the manipulation of femtosecond laser filamentation by introducing a novel gaseous lattice medium with the alternating positive and negative refractive index distribution at different stages of filamentation. The results show that the filament length has greatly been extended and a multi-filament array can be formed by the gas lattice medium. It has been found that additional focusing and discrete diffraction provided by the gas lattice medium contribute to a new dynamic equilibrium in the filamentation. As a result, a varied cross-section pattern, higher field intensity, and electron density along the filamentation are obtained. Our approach provides a new way to manipulate filamentation for many practical photonic applications.
Single longitudinal-mode passively Q-switched 1537 nm Er:Yb:Lu2Si2O7 pulse microchip laser
Authors: Chen Yujin , Huang Jianhua , Lin Yanfu , Gong Xinghong , Luo Zundu , Huang Yidong
Published: November 2020

A single longitudinal-mode passively Q-switched 1537 nm pulse microchip laser was realized in an Er:Yb:Lu2Si2O7 crystal. The effects of the pump beam diameter and output mirror transmission on pulse characteristics of the Er:Yb:Lu2Si2O7 microchip laser were investigated, when a Co2+:MgAl2O4 saturable absorber with an initial transmission of 95% was used. At an absorbed pump power of 3.4 W, a 1537 nm single-longitudinal-mode pulse laser with energy of 25.8 µJ, repetition frequency of 0.89 kHz, duration of 4.3 ns, and peak output power of 6.0 kW was obtained, when the pump beam diameter and output mirror transmission were 420 µm and 3.0%, respectively. The beam quality factor of output laser with TEM00 mode was less than 1.3.
Accurate prediction of multilayered residual stress in fabricating a mid-infrared long-wave pass filter with interfacial stress measurements
Authors: Tien Chuen-Lin , Lin Hong-Yi
Published: November 2020

We present an accurate approach to predict the residual stress in a multilayered mid-infrared long-wave pass filter (MIR-LWPF) by using interfacial stress measurements. Magnesium fluoride (MgF2) and zinc sulfide (ZnS) thin films were used to fabricate 7-layer (MgF2/ZnS)3/MgF2 MIR-LWPF devices by electron-beam evaporation with ion-assisted deposition technique. The interfacial stress between the high-index of ZnS and low-index of MgF2 thin film materials was obtained from the residual stress measurements based on Twyman-Green interferometer and fast Fourier transformation (FFT) method. The modified Ennos formula was used to estimate the residual stress in the (MgF2/ZnS)3/MgF2 multilayered thin films. The difference between the predicted stress value and the measured value is 28 MPa by the proposed method. In the MIR-LWPF design of (MgF2/ZnS)3/MgF2 multilayer structure, the optical transmittance at a near-infrared wavelength of 1.0 µm to 2.5 µm is less than 10%, and the transmittance at a mid-infrared wavelength of 2.5 µm to 7.5 µm is greater than 93%. The proposed method can accurately evaluate and predict residual stress in fabricating mid-infrared long-wave pass filter device which possesses low residual stress as well as lower surface roughness.
Denoising ghost imaging under a small sampling rate via deep learning for tracking and imaging moving objects
Authors: Hu Hong-Kang , Sun Shuai , Lin Hui-Zu , Jiang Liang , Liu Wei-Tao
Published: November 2020

Ghost imaging (GI) usually requires a large number of samplings, which limit the performance especially when dealing with moving objects. We investigated a deep learning method for GI, and the results show that it can enhance the quality of images with the sampling rate even down to 3.7%. With a convolutional denoising auto-encoder network trained with numerical data, blurry images from few samplings can be denoised. Then those outputs are used to reconstruct both the trajectory and clear image of the moving object via cross-correlation based GI, with the number of required samplings reduced by two-thirds.
Detector self-tomography
Authors: Cónsul Raúl , Luis Alfredo
Published: November 2020

We present an intuitive model of detector self-tomography. Two identical realizations of the detector are illuminated by an entangled state that connects the joint statistics in a way in which each detector sees the other as a kind of mirror reflection. A suitable analysis of the statistics reveals the possibility of fully characterizing the detector. We apply this idea to Bell-type experiments, revealing their nonclassical nature.
Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia
Authors: Trevisiol Andrea , Kusch Kathrin , Steyer Anna M. , Gregor Ingo , Nardis Christos , Winkler Ulrike , Köhler Susanne , Restrepo Alejandro , Möbius Wiebke , Werner Hauke B. , Nave Klaus-Armin , Hirrlinger Johannes
Published: November 2020

In several neurodegenerative disorders, axonal pathology may originate from impaired oligodendrocyte-to-axon support of energy substrates. We previously established transgenic mice that allow measuring axonal ATP levels in electrically active optic nerves. Here, we utilize this technique to explore axonal ATP dynamics in the Plpnull/y mouse model of spastic paraplegia. Optic nerves from Plpnull/y mice exhibited lower and more variable basal axonal ATP levels and reduced compound action potential (CAP) amplitudes, providing a missing link between axonal pathology and a role of oligodendrocytes in brain energy metabolism. Surprisingly, when Plpnull/y optic nerves are challenged with transient glucose deprivation, both ATP levels and CAP decline slower, but recover faster upon reperfusion of glucose. Structurally, myelin sheaths display an increased frequency of cytosolic channels comprising glucose and monocarboxylate transporters, possibly facilitating accessibility of energy substrates to the axon. These data imply that complex metabolic alterations of the axon–myelin unit contribute to the phenotype of Plpnull/y mice.
Germination response of diverse wild and landrace chile peppers (Capsicum spp.) under drought stress simulated with polyethylene glycol
Authors: Bernau Vivian M. , Jardón Barbolla Lev , McHale Leah K. , Mercer Kristin L.
Published: November 2020

Responses to drought within a single species may vary based on plant developmental stage, drought severity, and the avoidance or tolerance mechanisms employed. Early drought stress can restrict emergence and seedling growth. Thus, in areas where water availability is limited, rapid germination leading to early plant establishment may be beneficial. Alternatively, germination without sufficient water to support the seedling may lead to early senescence, so reduced germination under low moisture conditions may be adaptive at the level of the population. We studied the germination response to osmotic stress of diverse chile pepper germplasm collected in southern Mexico from varied ecozones, cultivation systems, and of named landraces. Drought stress was simulated using polyethylene glycol solutions. Overall, survival time analysis revealed delayed germination at the 20% concentration of PEG across all ecozones. The effect was most pronounced in the genotypes from hotter, drier ecozones. Additionally, accessions from wetter and cooler ecozones had the fastest rate of germination. Moreover, accessions of the landracesCosteño RojoandTustagerminated more slowly and incompletely if sourced from a drier ecozone than a wetter one, indicating that slower, reduced germination under drought stress may be an adaptive avoidance mechanism. Significant differences were also observed between named landraces, with more domesticated types from intensive cultivation systems nearly always germinating faster than small-fruited backyard- or wild-types, perhaps due to the fact that the smaller-fruited accessions may have undergone less selection. Thus, we conclude that there is evidence of local adaptation to both ecozone of origin and source cultivation system in germination characteristics of diverse chile peppers.
Long-term outcomes of psychological interventions on children and young people’s mental health: A systematic review and meta-analysis
Authors: Pilling Stephen , Fonagy Peter , Allison Elizabeth , Barnett Phoebe , Campbell Chloe , Constantinou Matthew , Gardner Tessa , Lorenzini Nicolas , Matthews Hannah , Ryan Alana , Sacchetti Sofia , Truscott Alexandra , Ventura Tamara , Watchorn Kate , Whittington Craig , Kendall Tim
Published: November 2020

Background

Over 600 RCTs have demonstrated the effectiveness of psychosocial interventions for children and young people’s mental health, but little is known about the long-term outcomes. This systematic review sought to establish whether the effects of selective and indicated interventions were sustained at 12 months.

Method

We conducted a systematic review and meta-analysis focusing on studies reporting medium term outcomes (12 months after end of intervention).

Findings

We identified 138 trials with 12-month follow-up data, yielding 165 comparisons, 99 of which also reported outcomes at end of intervention, yielding 117 comparisons. We found evidence of effect relative to control at end of intervention (K = 115, g = 0.39; 95% CI: 0.30–0.47 I2 = 84.19%, N = 13,982) which was maintained at 12 months (K = 165, g = 0.31, CI: 0.25–0.37, I2 = 77.35%, N = 25,652) across a range of diagnostic groups. We explored the impact of potential moderators on outcome, including modality, format and intensity of intervention, selective or indicated intervention, site of delivery, professional/para-professional and fidelity of delivery. We assessed both risk of study bias and publication bias.

Conclusions

Psychosocial interventions provided in a range of settings by professionals and paraprofessionals can deliver lasting benefits. High levels of heterogeneity, moderate to high risk of bias for most studies and evidence of publication bias require caution in interpreting the results. Lack of studies in diagnostic groups such as ADHD and self-harm limit the conclusions that can be drawn. Programmes that increase such interventions’ availability are justified by the benefits to children and young people and the decreased likelihood of disorder in adulthood.
Interrogative suggestibility in the elderly
Authors: Biondi Silvia , Mazza Cristina , Orrù Graziella , Monaro Merylin , Ferracuti Stefano , Ricci Eleonora , Di Domenico Alberto , Roma Paolo
Published: November 2020

Interrogative suggestibility (IS) describes the extent to which an individual behavioral response is affected by messages communicated during formal questioning within a closed social interaction. The present study aimed at improving knowledge about IS in the elderly (aged 65 years and older), in particular about its association with both emotive/affective and cognitive variables. The sample (N= 172) was divided into three groups on the basis of age: late adult (aged 55–64,N= 59), young elderly (aged 65–74,N= 63), and elderly (aged 75 and older,N= 50). Cognitive (i.e., Kaufman Brief Intelligence Test-2, Rey Auditory Verbal Learning Test), emotive/affective (i.e., Rosenberg Self-Esteem Scale, Marlowe–Crowne Social Desirability Scale, Penn State Worry Questionnaire) and suggestibility measures (i.e., Gudjonsson Suggestibility Scale-2) were administered. In order to identify differences and associations between groups in IS, cognitive and emotive/affective variables, ANOVAs tests and Pearson’s correlations were run. Furthermore, moderation analyses and hierarchical regression were set to determine whether age, cognitive and emotive/affective variables predicted IS components (i.e., Yield and Shift). Finally, machine learning models were developed to highlight the best strategy for classifying elderly subjects with high suggestibility. The results corroborated the significant link between IS and age, showing that elderly participants had the worst performance on all suggestibility indexes. Age was also the most important predictor of both Yield and Shift. Results also confirmed the important role of non-verbal intelligence and memory impairment in explaining IS dimensions, showing that these associations were stronger in young elderly and elderly groups. Implications about interrogative procedures with older adults were discussed.