bluuebunny/crossref_metadata_2025 huggingface dataset:
Discussion on Protein Metabolism and Requirement of Aerobics Athletes during Training Based on Multisensor Data Fusion
Authors: Gong Hua , Chen Shuang , Yu Shuo , Liu Dong , Li Xin , Shan Zeliang , Kong Fan , Yan Zhi , Han Feng
Published: March 2022

Competitive aerobics has emerged as a highly competitive sport beyond its own physical limit. Modern competitive aerobics competition is very fierce; athletes cannot only rely on a specific competitive skill to achieve good results. Protein is the physical basis of life activity. The life activity of human body is closely related to protein, and protein is closely related to human exercise ability. This article aims to study protein metabolism and demand of aerobics athletes during training based on multisensor data fusion. A total of 26 female aerobics athletes were randomly divided into two groups: exercise group and exercise + nutrition group. According to the characteristics of human motion, a comprehensive measurement acquisition sensor system for collecting human motion information is designed and implemented, and the system is used to monitor the subject’s protein condition in real time. The subjects took protein nutrient solution before breakfast every day. The dynamic recognition algorithm designed in this paper also has shortcomings, and the monitoring protein method based on gait and other signs is not completely correct. The experiment lasted for 7 weeks. The results showed that the level of serum transferrin receptor decreased significantly in the quiet + nutrition group for 4 weeks, which was significantly different from that at 0 and 3 weeks in the same group (

P

 < 0.01) and was significantly different from that in the same group at 7 weeks (

P

 < 0.05). In the exercise group, the level of serum transferrin receptor increased significantly at 5 weeks, compared with the same group at 0 and 3 weeks (

P

 < 0.05).
Effects of Dietary Chlorogenic Acid Supplementation Derived from Lonicera macranthoides Hand-Mazz on Growth Performance, Free Amino Acid Profile, and Muscle Protein Synthesis in a Finishing Pig Model
Authors: Wang Wenlong , Li Fengna , Duan Yehui , Guo Qiuping , Zhang Lingyu , Yang Yuhuan , Yin Yunju , Han Mengmeng , Gong Saiming , Li Jianzhong , He Shanping , Yin Yulong
Published: March 2022

Chlorogenic acid (CGA), as one of the richest polyphenol compounds in nature, has broad applications in many fields due to its various biological properties. However, initial data on the effects of dietary CGA on protein synthesis and related basal metabolic activity has rarely been reported. The current study is aimed at (1) determining whether dietary CGA supplementation improves the growth performance and carcass traits, (2) assessing whether dietary CGA alters the free amino acid profile, and (3) verifying whether dietary CGA promotes muscle protein synthesis in finishing pigs. Thirty-two (Large × White × Landrace) finishing barrows with an average initial body weight of

71.89
±
0.92

 kg were randomly allotted to 4 groups and fed diets supplemented with 0, 0.02%, 0.04%, and 0.08% CGA, respectively. The results indicated that, compared with the control group, dietary supplementation with 0.04% CGA slightly stimulated the growth performance of pigs, whereas no significant correlation was noted between the dietary CGA levels and animal growth (

P
>
0.05

). Furthermore, the carcass traits of pigs were improved by 0.04% dietary CGA (

P
<
0.01

). In addition, dietary CGA significantly improved the serum free amino acid profiles of pigs (

P
<
0.01

), while 0.04% dietary CGA promoted more amino acids to translocate to skeletal muscles (

P
<
0.05

). The relative mRNA expression levels of SNAT2 in both longissimus dorsi (LD) and biceps femoris (BF) muscles were augmented in the 0.02% and 0.04% groups (

P
<
0.05

), and the LAT1 mRNA expression in the BF muscle was elevated in the 0.02% group (

P
<
0.05

). We also found that dietary CGA supplementation at the levels of 0.04% or 0.08% promoted the expression of p-Akt and activated the mTOR-S6K1-4EBP1 axis in the LD muscle (

P
<
0.05

). Besides, the MAFbx mRNA abundance in the 0.02% and 0.04% groups was significantly lower (

P
<
0.05

). Our results revealed that dietary supplementation with CGA of 0.04% improved the free amino acid profile and enhanced muscle protein biosynthesis in the LD muscle in finishing pigs.
Embryo Density and Its Neutrality in Day-3 Embryo Development: A Retrospective Cohort Study
Authors: Shi Cheng , Sun Tie Cheng , Meng Shi Hui , Wang Ping , Liang Rong , Duan Sheng Nan , Han Hong Jing , Liu Ya Nan , Shen Huan , Chen Xi
Published: March 2022

Introduction. Many studies have shown that embryo density has an impact on day-3 embryo-developmental outcomes; however, embryo density remains controversial in clinical practice. We aimed to evaluate the association between embryo density and day-3 embryo-developmental outcomes in real world with the largest sample size. Methods. In 2018, we identified 10941 day-3 embryos from all female patients (n = 1568) in the study. The embryos were allocated to three embryonic densities: 30 μl/embryo (individual culture), 15 μl/embryo, and 10 μl/embryo (group culture). The primary outcomes were cleaving speed, quality, and proportion of successful implantations. The generalized estimate equation (GEE) model was used both in the univariate analysis and multivariable logistic regression analyses to investigate the relationship between embryo density and embryo-developmental outcomes. Results. There were 3064, 5695, and 2182 embryos in the 30 μl/embryo group, 15 μl/embryo group, and 10 μl/embryo group, respectively. The proportions of 7–10 cell embryos were 57.2%, 56.1%, and 58.3% in three densities with no statistical significance (

P
=
0.37

), respectively. The proportions of morphologically good embryos were 20%, 20.3%, and 20% in three densities with no statistical significance (

P
=
0.85

), respectively. Proportions of implanted embryos were 37.7%, 37.1%, and 27.8% with no statistical significance (

P
=
0.36

), respectively. After adjustment for confounders, which were significant in the univariate analysis, the embryo density was still not associated with day-3 embryo-cleaving speed, day-3 embryo quality, and day-3 embryo-implanting potential (all

P
>
0.05

). Conclusion. In a 30 μl microdrop, the culturing embryos with embryo densities of 15, 10, and 30 μl/embryo (from zygotes to day 3) had similar developmental outcomes. The embryo density had no impact on day-3 embryo development.
A Meta-Analysis of Incidence of Catheter-Related Bloodstream Infection with Midline Catheters and Peripherally Inserted Central Catheters
Authors: Chen Xin , Liang Min
Published: March 2022

In order to provide reference for the prevention and treatment of CRBSI during clinical intravenous infusion therapy, this paper investigates the incidence of catheter-related bloodstream infection (CRBSI) in the treatment of midline catheters (MCs) and peripherally inserted central catheters (PICCs) by intravenous infusion. Web of Science, PubMed, Scopus, Embase, Cochrane Library, and ProQuest are searched to collect CRBSI-related studies on MC and PICC. The retrieval time is from the database construction to August 2020. Two researchers independently searched and screened literature quality evaluation and extracted data according to inclusion and exclusion criteria, and RevMan 5.3 software was used for analysis. Eleven studies are included, with a total of 33809 patients. The incidence of CRBSI in the MC group is 0.599% (43/7079), and that in the PICC group is 0.4993% (133/26630). Meta-analysis showed that the incidence of CRBSI in the MC group is higher than that in the PICC group (OR = 0.72, 95% CI = 0.43–1.08,

P
=
0.11

), and the difference is statistically significant when low-quality studies are excluded (OR = 0.60, 95% CI = 0.39–0.93,

P
=
0.02

). There is no significant difference in the incidence of CRBSI between MC group and PICC group (

P
>
0.05

), American subgroup (OR = 0.52), and British subgroup (OR = 4.86), the results of the two groups are opposite, and the incidence of CRBSI between the MC group and PICC group is statistically significant. There is no significant difference in the incidence of CRBSI between the adult and other subgroups (all

P
>
0.05

). There is no significant difference in the incidence of CRBSI between the MC group and the PICC group (

P
>
0.05

). Overall, the inter-study stability is general, the quality is good and the medium is good, and there is no obvious publication bias. The risk of CRBSI in MC and PICC is systematically evaluated and meta-analyzed for the first time. The incidence of CRBSI in MC group is lower than that in PICC group during intravenous infusion therapy. Under the same conditions, MC patients can be given priority for intravenous infusion therapy. More high-quality and child-related studies are needed to further evaluate and explore the risk of CRBSI between MC and PICC.
Analysis of Coupling Coordination Degree between Big Health Industry and Pension Service
Authors: Luo Liqiong
Published: March 2022

With the aging of the population, the problem of providing for the aged has been paid more and more attention. The big health industry and old-age care services will complement and promote each other in terms of industrial factors, industrial layout, and policy linkage and form a coupling effect in this process. Hospital services and pension services are professional property service formats, and they are also the exploration achievements of the property management industry in implementing the supply-side structural reform, transformation, upgrading, and development and are indispensable forces for the property management industry to participate in building a better life. The health and happiness of the elderly is an important symbol of social civilization and progress, and it is also an important content of implementing the Healthy China Action. The pension industry serving the healthy life of the aged population will form a huge demand for the big health industry, and its development will drive the big health industry. Based on the background of the big health system, this paper analyzes the current situation and crux of the development of aged care services in China and puts forward ways to improve the quality of aged care services by optimizing the effective supply of aged care services, improving the environment of aged care services, and strengthening the precise supervision of aged care services.
Optimizing the IPSA Conditions to Improve the Treatment Plan Quality in Brachytherapy for Cervical Cancer
Authors: Yang Xinglong , Li Zhouyu , Cai Zhantuo , Tang Xi , Liu Jinquan , Cui Shuzhong , Li Mingyi
Published: March 2022

Recent prevalent use of three-dimensional image-guided brachytherapy (3D brachytherapy) has dramatically improved the treatment outcomes of cervical cancer. Inverse planning simulated annealing (IPSA) is one of the commonly used algorithms in 3D brachytherapy, but different conditions may affect the treatment plan quality. In this study, we compared HRCTV (high-risk clinical target volume) D90 (dose prescription) and HRCTV D95 D2cc (dose received by 2.0cc) of the rectum, bladder, and sigmoid in 30 patients with cervical cancer under four IPSA conditions. The HRCTV D90 (mean ± SD cGy) was 607.32 ± 37.86, 599.01 ± 23.62, 598.67 ± 13.07, and 596.45 ± 10.94 in four groups, respectively. The HRCTV D95 was 558.19 ± 38.51, 558.17 ± 25.72, 557.03 ± 16.12, and 555.26 ± 12.78, respectively. The sigmoid D2cc was 282.96 ± 44.84, 273.14 ± 60.69, 268.94 ± 62.32, and 292.69 ± 52.44. HRCTV D90, HRCTV D95, and sigmoid D2cc were not statistically different among the four groups (p > 0.05). However, the target fitness in group one, especially at the cervix, was poor. The rectum D2cc was 351.49 ± 32.90, 361.49 ± 28.09, 370.82 ± 24.44, and 375.33 ± 30.90. The rectum D2cc in group one was the lower than that in group three and group four (p<0.05). The bladder D2cc was 423.59 ± 31.39, 380.75 ± 37.25, 383.27 ± 32.55, and 385.22 ± 25.79. The bladder D2cc in group one was higher than the other groups (p<0.05). The maximum rectum limit dose (400cGy) is lower than the bladder (500cGy), and HRCTV is a whole in the IPSA algorithm; these result in the insufficiency or even absence of cervix dose that first need to meet in clinics. In conclusion, IPSA condition optimization can improve the quality of treatment plan in 3D brachytherapy and make it closer to clinical practice.
Single-Cell Sequencing Revealed Pivotal Genes Related to Prognosis of Myocardial Infarction Patients
Authors: Zhou Jiamin , Wen Tong , Li Qing , Chen Zhixin , Peng Xiaoping , Wei Chunying , Wei Yunfeng , Peng Jingtian , Zhang Wei
Published: March 2022

Objectives. Myocardial infarction (MI) is a common cardiovascular disease. Histopathology is a main molecular characteristic of MI, but often, differences between various cell subsets have been neglected. Under this premise, MI-related molecular biomarkers were screened using single-cell sequencing. Methods. This work examined immune cell abundance in normal and MI samples from GSE109048 and determined differences in the activated mast cells and activated CD4 memory T cells, resting mast cells. Weighted gene coexpression network analysis (WGCNA) demonstrated that activated CD4 memory T cells were the most closely related to the turquoise module, and 10 hub genes were screened. Single-cell sequencing data (scRNA-seq) of MI were examined. We used

t

-distributed stochastic neighbor embedding (

t

-SNE) for cell clustering. Results. We obtained 8 cell subpopulations, each of which had different marker genes. 7 out of the 10 hub genes were detected by single-cell sequencing analysis. The expression quantity and proportion of the 7 genes were different in 8 cell clusters. Conclusion. In general, our study revealed the immune characteristics and determined 7 prognostic markers for MI at the single-cell level, providing a new understanding of the molecular characteristics and mechanism of MI.
Integrated Geologic Modeling of Fault-Block Reservoir: A Case Study of Ss Oil Field
Authors: Xiao Zhipeng , Wei Zhang , Tang Zhengyin , Guo Jianqing , Geng Ruijuan , Gou Tuobing
Published: March 2022

The Ss oil field is found in the Turpan-Hami Basin’s Taipei Sag’s arc structural belt. This reservoir has a complicated character that has a significant impact on reservoir modeling and production prediction. This is a fault-block reservoir with ultralow permeability and low porosity that is divided by 57 faults. A static model was constructed by Petrel software based on reinterpretation of original log and core data and seismic information so as to clarify the spatial distribution of oil and water in the reservoir and to fit the development history of the later simulated reservoir. The integrated geological modeling approach is described in this work using the Ss reservoir as an example. A 3D structural model was built based on the spatial cutting relationship between the layer model and the fault, and the model’s quality was improved by breakpoint data, which more correctly depicted the structural properties of the research area. The lithofacies model was built within the restrictions of sedimentary facies using the sequential Gaussian simulation (SGS) stochastic modeling approach, which is paired with variogram data analysis to achieve the range value. To obtain the porosity and permeability model, the empirical formula of porosity and permeability, the SGS method, and the variation range value was input into the lithofacies model. It is important to note that the input lithofacies and property models have values of the same range. To gain the water saturation model, the distinct

S

w

function formulas of the

S
1
~
S
4

layer derived from the

J

S

w

function were fed into the software. The NTG model was created according to the lower limit of porosity, which is 11%. The merging of detailed reservoir description and simulation led to the establishment of the Ss reservoir geological model. In the plane, the scale of the geological model has reached the meter level and decimeter level in the longitudinal direction. It also offers a framework for optimum reservoir modeling for complex fault-block reservoirs. This method improves the accuracy and precision of the model by reflecting the reservoir’s heterogeneity and the oil-water distribution. It could provide more details for future reservoir research such as fine reservoir simulation.
The Nonsymmetric Flavor Transition Matrix and the Apparent P Violation
Authors: Rong Shu-Jun , Xu Ding-Hui
Published: March 2022

The leptonic mixing parameters of high precision and the next-generation neutrino telescopes make it possible to test new physics in the flavor transition of the high-energy astrophysical neutrinos (HAN). We introduce a nonsymmetric matrix to modify the predictions of the standard flavor transition matrix. It is constructed with the mixing matrix in vacuum and that at the source of the HAN. The mismatch of the mixing matrices results in the new expectation of the flavor ratio of the HAN at Earth. It also leads to a secondary effect called the apparent P violation (APV). The quantitative analyses of the new effects are performed with a moderate setup of the parameters at the source of the HAN. The correlations between the mixing parameters and the new predictions are shown. From the correlations, the dominant parameters determining the new-physics effects are identified.
A Review on the Parameters Affecting the Mechanical, Physical, and Thermal Properties of Natural/Synthetic Fibre Hybrid Reinforced Polymer Composites
Authors: Bichang’a DO , Aramide FO , Oladele IO , Alabi OO
Published: March 2022

The global drive towards a circular economy that emphasizes sustainability in production processes has increased the use of agro-based raw materials like natural fibres in applications that have long been dependent on inorganic raw materials. Natural fibres provide an eco-friendly, more sustainable, and low cost alternative to synthetic fibres that have been used for a long time in the development of composite materials. However, natural fibres are associated with high water absorption capacity due to their hydrophilic nature leading to poor compatibility with hydrophobic polymeric matrices, thus lower mechanical properties for various applications. Hybridization of natural fibres with synthetic fibres enhances the mechanical performance of natural fibres for structural and nonstructural applications such as automobile, aerospace, marine, sporting, and defense. There have been increased research interests towards natural/synthetic fibre hybrid composites in the past two decades (2001–2021) to overcome the identified limitations of natural fibres. Therefore, understanding the parameters affecting the properties and potential of using natural and synthetic fibre reinforcements to develop hybrid composites is of great interest. The review showed that using appropriate fibre orientation, fibre weight fraction and stacking sequence yields good mechanical, physical, and thermal properties that are competitive with what only synthetic fibre reinforced composites can achieve. In addition, these properties can be improved through pretreatment of natural fibres using different chemicals. This paper provides in review form the parameters affecting the mechanical, physical, and thermal properties of natural/synthetic fibre hybrid reinforced polymer composites from the year 2001 to 2021.
Regularity for 3D Inhomogeneous Naiver–Stokes Equations in Vishik Spaces
Authors: Kim Jae-Myoung
Published: March 2022

In this short paper, we consider the conditional regularity for the 3D inhomogeneous incompressible Navier–Stokes equations in Vishik spaces and give regularity criterion of strong solutions.
Position Estimation and Error Correction of Mobile Robots Based on UWB and Multisensors
Authors: Li Jie , Xue Jiameng , Fu Di , Gui Chao , Wang Xingsong
Published: March 2022

Since there are many interferences in the indoor environment, it is difficult to achieve the precise positioning of the mobile robot using a single sensor. This paper presents a position estimation and positioning error correction method of mobile robots based on multisensor data. The robot’s positioning sensor includes ultra-wideband (UWB) components, inertial measurement unit (IMU), and encoders. UWB multipath interference causes more ranging errors, which can be reduced by the correction equation after data fitting. The real-time coordinates of the UWB robot tag can be calculated based on multiple UWB anchor data and the least squares method. The coordinate data

x

c

,

y

c

are acquired by UWB positioning subsystem, and the velocity data

x
̇

c

,

y
̇

c

are collected by IMU together with encoders. The multisensor data continuously update Kalman filter and estimate robot position. In the positioning process, the positioning data of different sensors can be mutually corrected and supplemented. The results of UWB ranging correction experiments indicate that data fitting can improve the UWB positioning accuracy. In the multisensor positioning experiments, compared with a single sensor, the positioning method based on data fusion of UWB, IMU, and encoders has higher accuracy and adaptability. When UWB signals are interfered or invalid, other sensors can still work normally and complete the robot positioning process. The multisensor positioning method not only improves the robot positioning accuracy but also has stronger environmental adaptability.
Verification of the Efficacy of Passive Autocatalytic Recombiners in a Typical Pressurized Water Reactor under a Station Blackout Condition
Authors: Hong Daegwang , Cho Donghyun , Kim Jinwoo , Diab Aya , Cildag Cigdem
Published: March 2022

The presence of a stable stratified gas cloud inside the containment near or at the flammability limit may lead to deflagration or even detonation which may challenge the containment and cause a radioactive material release into the environment. To mitigate this risk, a number of approaches have been proposed, for example, containment inerting or venting and use of passive autocatalytic recombiners or igniters. However, for these measures to be effective, a thorough analysis of the hydrogen dispersion and associated phenomena is indispensable during the design phase as well as the mitigation phase during a severe accident. In this work, a MAAP analysis is performed to assess the hydrogen risk in a typical pressurized water reactor (PWR) containment. An extended station blackout (SBO) was chosen as an initiating event given its high contribution to the core damage frequency. RCS depressurization and external injection are mitigation techniques implemented consecutively to extend the coping capability of the plant for the extended SBO scenario. A sensitivity study is performed to select the combination of timing and flow rate that generate the most severe case for the “in-vessel phase of hydrogen generation.” Subsequently, a number of passive autocatalytic recombiners (PARs) were implemented to mitigate the hydrogen risk during the first three days of the accident. The Shapiro diagram is used to assess the flammability condition of the containment atmosphere based on MAAP analysis. The results show that the gas mixture composition is acceptable in the majority of the containment compartments and only marginally acceptable in the cavity. Even under the conservative conditions of the accident, the simulation results confirmed the sufficiency of recombiners alone without igniters in the low hydrogen concentration zones, while for compartments close to the sources, additional mitigation may be needed.
CaMKK2 Promotes the Progression of Ovarian Carcinoma through the PI3K/PDK1/Akt Axis
Authors: Chen Zhen , Sun Xingxing , Xia Zhiyan , Wang Jihong , Guo Nan , Zhang Yi
Published: March 2022

Objective. To explore the functional role of Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in the progression of ovarian carcinoma (OC). Methods. RT-qPCR analysis and western blot were conducted to detect the mRNA and protein expression of CaMKK2, PI3K, PDK1 and Akt in OC tissues and cells, respectively. CCK-8 assay, transwell migration assay and flow cytometry were used to measure cell proliferation, migration and apoptosis, respectively. Results. CaMKK2, PI3K, PDK1 and Akt were highly expressed in OC tissues compared with the corresponding controls. CaMKK2 knockdown significantly suppressed the mRNA and protein expression of PI3K, PDK1 and Akt in HO8910 and OV90 cells. Moreover, CaMKK2 knockdown could dramatically repress cell proliferation, migration, and markedly elevate cell apoptosis in HO8910 and OV90 cells. Conclusions. CaMKK2 played a promotion role in OC progression via activating the PI3K/PDK1/Akt axis.
Evaluation Method of Economic Growth Quality of Tourism-Driven Real Estate Based on AHP
Authors: Li Qingmin
Published: March 2022

The traditional tourism-driven real estate economic growth quality evaluation model has the problem of low fitting degree and dynamic degree. In order to solve this problem, a tourism-driven real estate economic growth quality evaluation method based on an analytic hierarchy process (AHP) is proposed. In order to reduce the solution scale of tourism-driven real estate economic growth quality evaluation, the analytic hierarchy process is used to calculate the possibility index, severity index, and economic growth quality index of tourism-driven real estate economic growth and screen and rank the economic growth quality. The discrete zoning model is used to determine the economic growth level of tourism-driven real estate. Using the Mahalanobis distance of multiattribute vector of economic growth quality evaluation index, the distance from the risk element to positive ideal solution and negative ideal solution is defined. By calculating the closeness of data economic growth quality element, this paper constructs a tourism-driven real estate economic growth quality evaluation model. The experimental results show that the model has high dynamics and reliability and greatly improves the joint evaluation effect of tourism-driven real estate economic growth quality.
Teachers' and Students' Roles in Promoting Cooperative Learning at Haramaya, Dire Dawa, and Jigjiga Universities, Ethiopia
Authors: Seyoum Yilfashewa , Molla Solomon
Published: March 2022

The purpose of this study was to analyze the roles of instructors and students to implement cooperative learning in eastern Ethiopian higher learning institutions. Using a survey design, purposive and stratified random sampling techniques were used to select 1244 respondents (students, instructors, college deans, department heads, and cooperative learning coordinators) from three universities. Data were collected using questionnaires, interviews, and observations. The mean, standard deviation, and ANOVA were used for analysis of the data. The results revealed that instructors were not acting as facilitators and were not offering guidance on how students should collaborate. Almost every instructor placed an emphasis on the lecture method. As evidenced by the data, the majority of instructors have a solid understanding of cooperative learning. However, owing to heavy workloads, large class sizes, and other factors, cooperative learning was not implemented adequately. Students failed to take ownership of their own learning and failed to share their information, talents, and experiences with one another. The constraints to implementing cooperative learning were inadequate responsibility sharing, inequitable work assignments, and a lack of consideration for diverse ability grouping. As a result, instructors must understand how to arrange learning settings in such a way that positive interdependence, individual accountability, proper use of social skills, and group processing are promoted. Moreover, program leaders should strengthen their monitoring and support of the educational process to ensure that instructors and students practice cooperative learning. It is critical for university quality assurance experts to plan and deliver training on cooperative learning and its implementation.
Ulam-Hyers-Rassias Stability of Nonlinear Differential Equations with Riemann-Liouville Fractional Derivative
Authors: El-hady El-sayed , Ben Makhlouf Abdellatif , Boulaaras Salah , Mchiri Lassaad
Published: March 2022

Fractional derivatives are used to model the transmission of many real world problems like COVID-19. It is always hard to find analytical solutions for such models. Thus, approximate solutions are of interest in many interesting applications. Stability theory introduces such approximate solutions using some conditions. This article is devoted to the investigation of the stability of nonlinear differential equations with Riemann-Liouville fractional derivative. We employed a version of Banach fixed point theory to study the stability in the sense of Ulam-Hyers-Rassias (UHR). In the end, we provide a couple of examples to illustrate our results. In this way, we extend several earlier outcomes.
The Prognostic Value and Immunological Role of STEAP1 in Pan-Cancer: A Result of Data-Based Analysis
Authors: Zhao Chen , Xiong Kewei , Ji Zhiqiang , Liu Fengming , Li Xiangpan
Published: March 2022

Purpose. This study is aimed at systematically analyzing the expression, function, and prognostic value of six transmembrane epithelial antigen of the prostate 1 (STEAP1) in various cancers. Methods. The expressions of STEAP1 between normal and tumor tissues were analyzed using TCGA and GTEx. Clinicopathologic data was collected from GEPIA and TCGA. Prognostic analysis was conducted by Cox proportional hazard regression and Kaplan-Meier survival. DNA methylation, mutation features, and molecular subtypes of cancers were also investigated. The top-100 coexpressed genes with STEAP1 were involved in functional enrichment analysis. ESTIMATE algorithm was used to analyze the correlation between STEAP1 and immunity value. The relationships of STEAP1 and biomarkers including tumor mutational burden (TMB), microsatellite instability (MSI), and stemness score as well as chemosensitivity were also illustrated. Results. Among 33 cancers, STEAP1 was overexpressed in 19 cancers such as cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), colon adenocarcinoma, and lymphoid neoplasm diffuse large B cell lymphoma while was downregulated in 5 cancers such as adrenocortical carcinoma, breast invasive carcinoma (BRCA), and kidney chromophobe renal cell carcinoma. STEAP1 has significant prognostic relationships in multiple cancers. 15 cancers exhibited differences of DNA methylation including bladder urothelial carcinoma, BRCA, and CESC. STEAP1 expression was positively correlated to immune molecules especially in thyroid carcinoma and negatively especially in uveal melanoma. STEAP1 was associated with TMB and MSI in certain cancers. In addition, STEAP1 was connected with increased chemosensitivity of drugs such as trametinib and pimasertib. Conclusions. STEAP1 was an underlying target for prognostic prediction in different cancer types and a potential biomarker of TMB, MSI, tumor microenvironment, and chemosensitivity.
Mycelium-Based Composite: The Future Sustainable Biomaterial
Authors: Alemu Digafe , Tafesse Mesfin , Mondal Ajoy Kanti
Published: March 2022

Because of the alarming rate of human population growth, technological improvement should be needed to save the environment from pollution. The practice of business as usual on material production is not creating a circular economy. The circular economy refers to an economic model whose objective is to produce goods and services sustainably, by limiting the consumption and waste of resources (raw materials, water, and energy). Fungal-based composites are the recently implemented technology that fulfills the concept of the circular economy. It is made with the complex of fungi mycelium and organic substrates by using fungal mycelium as natural adhesive materials. The quality of the composite depends on both types of fungi and substrate. To ensure the physicochemical property of the fabricated composite, mycelium morphology, bimolecular content, density, compressive strength, thermal stability, and hydrophobicity were determined. This composite is proven to be used for different applications such as packaging, architectural designs, walls, and insulation. It also has unique features in terms of low cost, low emission, and recyclable.
Simvastatin Combined with Resistance Training Improves Outcomes in Patients with Chronic Heart Failure by Modulating Mitochondrial Membrane Potential and the Janus Kinase/Signal Transducer and Activator of Transcription 3 Signaling Pathways
Authors: Wang Xiaowen , Yan Kaiyun , Wen Cuifeng , Wang Jiaqi
Published: March 2022

Background. Chronic heart failure (CHF) is the end stage of cardiac disease with a 5-year mortality rate reaching 50%. Simvastatin is an antioxidant with lipid-lowering effects, which is commonly used to treat CHF. Resistance training is a nondrug treatment for CHF and exerts a positive effect on both the myocardial structure and function. Objective. This study is aimed at exploring the effects and outcomes of simvastatin combined with resistance training on the mitochondrial membrane potential (MMP) of peripheral blood lymphocytes and the Janus kinase/signal transducer and activator of the transcription 3 (JAK/STAT3) signaling pathway in patients with CHF. Methods. One hundred and eleven patients with CHF were allocated to the control group (CNG) (

n
=
55

) and intervention group (IG) (

n
=
56

) using the random number table method. The CNG received simvastatin treatment only, whereas the IG received simvastatin treatment plus resistance training. Treatment efficacy, diastolic interventricular septal thickness (IVST), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDD), MMP fluorescence intensity, JAK mRNA and STAT3 mRNA relative expression levels, serum C-reactive protein (CRP), galectin-3, interleukin-6 (IL-6), N-terminal–probrain natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), and heart-type fatty acid-binding protein (H-FABP) levels were compared in both groups. Results. After 6 months of treatment, diastolic IVST, LVDD, and serum levels of CRP, galectin-3, IL-6, NT-proBNP, hs-cTnT, and H-FABP decreased in both groups and were lower in the IG than in the CNG (

P
<
0.05

), whereas LVEF, JAK and STAT3 mRNA relative expression levels, and MMP fluorescence intensity of peripheral blood lymphocytes were higher in the IG than in the CNG (

P
<
0.05

). Conclusion. Simvastatin combined with resistance training improves heart function and reduces myocardial damage as well as the occurrence of adverse cardiac events compared with simvastatin alone. The mechanism may be related to the increase of expression of MMP, JAK, and STAT3, the regulation of MMP and JAK/STAT3 signaling pathways in peripheral lymphocytes, the alleviation of mitochondrial damage, and the inhibition of inflammatory response.
Enhanced Authentication Protocol for the Internet of Things Environment
Authors: Chen Chien-Ming , Li Xuanang , Liu Shuangshuang , Wu Mu-En , Kumari Saru
Published: March 2022

The Internet of Things (IoT) is among the most promising technologies of the future, and its development has garnered attention worldwide. However, the rise of the IoT has been accompanied by a proportionate increase in security concerns regarding communication between IoT entities. Recently, Alzahrani et al. proposed an identity-based authentication and key agreement protocol for an IoT environment, wherein a physically unclonable function was employed. They claimed that their protocol can resist various types of attacks; however, after thorough analysis, we determined it to be ineffective against privileged internal attacks, physical IoT device capture attacks, stolen-verifier attacks, and known temporary information exposure attacks. To resolve these security weaknesses, we propose a new authentication and key agreement protocol. In addition, we demonstrate that the proposed protocol is provably secure in real-or-random (ROR) model and Burrows–Abadi–Needham (BAN) logic, resisting known attacks while incurring low communication and computation costs.
Study on the Method of Automatically Drawing Multiscale Engineering Geotechnical (Geological) Sections Step by Step of Engineering Layers including Lenses
Authors: Ji Guangjun , Zhao Nannan , Zhou Xiaoyuan , Wang Qian , Lu Yan , Cai Zizhao
Published: March 2022

Drawing the engineering sections automatically and efficiently is significant for the investigation results of geotechnical engineering to provide the scientific and detailed geological basis for urban planning and construction, but it is still difficult to draw the engineering geological sections automatically without manual edit. A method, taking the engineering strata in Quaternary loose sedimentary as the research object, was proposed to automatically draw multiscale engineering geological sections of engineering layers including lenses and strata pinch‐out based on the investigation results and borehole data of geotechnical (geological) engineering. Firstly, the spatial information of the top and bottom boundaries of any borehole layer were extracted, and then based on the stratigraphical column, the borehole layer was studied by a step‐by‐step coarsen from the finest stratigraphical column to the coarsest stratigraphical column, and the occupation relationship among layers was distinguished; secondly, from the coarsest stratigraphical column to the finest level stratigraphical column step‐by‐step and taking the radial basis function (RBF) interpolation as an example, top and bottom boundaries were interpolated, respectively, by following the order of current stratigraphical column; next, topological relationship among engineering layers was processed according to contact relationship of strata, and strata boundaries with 0 thickness were deleted; and finally, auxiliary information such as scaler and legend were added in section to complete the drawing of multiscale sections. Studies of one site case and one region case demonstrate that the method can perfectly and automatically draw the engineering geological section of engineering layers including lenses and strata pinch‐out.
Text Mining Based on the Lexicon-Constrained Network in the Context of Big Data
Authors: Wan Boyan , Sohail Mishal
Published: March 2022

Unstructured textual news data is produced every day; analyzing them using an abstractive summarization algorithm provides advanced analytics to decision-makers. Deep learning network with copy mechanism is finding increasing use in abstractive summarization, because copy mechanism allows sequence-to-sequence models to choose words from the input and put them directly into the output. However, since there is no explicit delimiter in Chinese sentences, most existing models for Chinese abstractive summarization can only perform character copy, resulting in inefficiency. To solve this problem, we propose a lexicon-constrained copying network that models multigranularity in both encoder and decoder. On the source side, words and characters are aggregated into the same input memory using a Transformer-based encoder. On the target side, the decoder can copy either a character or a multicharacter word at each time step, and the decoding process is guided by a word-enhanced search algorithm which facilitates the parallel computation and encourages the model to copy more words. Moreover, we adopt a word selector to integrate keyword information. Experiment results on a Chinese social media dataset show that our model can work standalone or with the word selector. Both forms can outperform previous character-based models and achieve competitive performances.
A Case of Persistent Bacillus cereus Bacteremia Responding to a Combination of Vancomycin and Gentamicin
Authors: Sasano Hiroshi , Yoshizawa Toshihiro , Suzuki Mai , Fukui Yukiko , Arakawa Ryutarou , Tamura Naoto , Naito Toshio
Published: March 2022

A 56-year-old woman with a history of connective tissue disease developed fever, and Bacillus cereus (B. cereus) was detected in blood cultures. Therefore, treatment with vancomycin (VCM) was initiated. Since her blood cultures persistently detected B. cereus despite peripheral intravenous catheter replacement and VCM treatment, concomitant treatment with gentamicin (GM) was started. Blood cultures then became negative. Persistent B. cereus bacteremia responded to combination therapy with VCM and GM. This combination therapy may increase the risk of developing renal dysfunction, but the risk can be mitigated by appropriate therapeutic drug monitoring (TDM) and dose adjustments to achieve successful treatment.
Nomogram for Predicting In-Hospital Mortality in Patients with Acute ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock after Primary Percutaneous Coronary Intervention
Authors: Wang Yudan , Liu Litian , Li Xinning , Dang Yi , Li Yingxiao , Wang Jiaqi , Qi Xiaoyong
Published: March 2022

Background. Mortality after percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients with cardiogenic shock (CS) remains high. However, the real-world risk factors for mortality in these patients are poorly defined. Objective. The aim of this study is to establish a clinical prognostic nomogram for predicting in-hospital mortality after primary PCI in STEMI patients with CS. Methods. This retrospective, multicenter, observational study included STEMI patients with CS who underwent PCI at 39 hospitals in Hebei Province from January 2018 to December 2019. A multivariate logistic regression model was used to identify the factors associated with in-hospital mortality. These factors were then incorporated into a nomogram and its performance was evaluated by discrimination, calibration, and clinical utility. Results. This study included 274 patients, among whom 179 died in hospital. Sex, random blood glucose on admission, ejection fraction after PCI, no-reflow, and intra-aortic balloon pump (IABP) were independently associated with in-hospital mortality (all

P
<
0.05

). In the training set, the nomogram showed a C-index of 0.819, goodness-of-fit of 0.08, and area under the receiver operating characteristic curve (AUC) of 0.819 (95%CI = 0.759–0.879). In the testing set, the C-index was 0.842, goodness-of-fit was 0.585, and AUC was 0.842 (95%CI = 0.715–0.970). The results indicate that the nomogram had good discrimination and good prediction accuracy and could achieve a good net benefit. Conclusion. We established and validated a nomogram that provided individual prediction of in-hospital mortality for STEMI patients with CS after PCI in a Chinese population.
Effect of Ergonomics-Based Piano Teaching on Teachers’ Physical and Mental Health and the Improvement of Sense of Happiness
Authors: Pi Jian
Published: March 2022

Background. As a special occupation of human beings, teachers have an important responsibility for society and students. As preachers, all their actions will affect the students. Teachers can be said to be the indicator of students’ happy life. According to a survey by educational institutions, more than 90% of teachers believe that work pressure is increasing. 64.2% of teachers have experienced job burnout, and the status quo of teachers' professional well-being is worrying. So we must pay attention to teachers’ happiness research. However, based on ergonomics, piano education is a kind of piano education to relieve fatigue and an important way to improve teachers’ happiness. Objective. Using the self-designed questionnaire related to teachers’ professional happiness, we investigated piano teachers in universities to understand the status quo of piano teachers’ professional happiness, reduce the fatigue of piano teaching, explore the relationship between work fatigue and college piano teachers’ professional happiness. Methods. This study combines qualitative and quantitative survey methods to make a qualitative analysis of the collected literature and survey and, at the same time, to make a quantitative survey of the collected data so as to get more scientific and accurate survey results. Results. According to the above analysis, this paper puts forward effective suggestions in order to reduce the fatigue of piano teaching and ultimately greatly improve the enthusiasm and efficiency of piano teaching, improve the professional happiness of piano teachers, and promote the effective progress of education. Conclusions. Through this study, the overall situation of piano teachers’ professional happiness in H University is general and the evaluation of piano teachers’ professional happiness in H University is mostly at the ordinary level. However, more than half of the teachers do not feel happy and excited at work, and some of them are tired and bored.
Observer‐Based PID Security Control for Discrete‐Time T‐S Fuzzy Systems under Distributed Dynamic Event‐Triggered Mechanism
Authors: Lin Sisi , Luo Mengzhuo , Zhong Shouming , Shi Kaibo , Tan Xingxu
Published: March 2022

This study addresses the observer‐based proportional‐integral‐derivative (PID) security control problem for nonlinear discrete‐time fuzzy systems subject to deception attacks. In order to reduce the burden of communication, a distributed dynamic event‐triggered mechanism (DETM) is proposed, and each sensor node is equipped with an event‐trigger generator. A new discrete‐time Takagi–Sugeno (T‐S) fuzzy model is established, in which both DETM and deception attacks are taken into consideration. Then, based on Lyapunov stability theory, the sufficient conditions for the input‐to‐state stability (ISS) are proposed, and the desired fuzzy PID controllers are given. Finally, a simulation example is provided to show the usefulness of the proposed approach.
Pathfinding for Mobile Robot Navigation by Exerting the Quarter-Sweep Modified Accelerated Overrelaxation (QSMAOR) Iterative Approach via the Laplacian Operator
Authors: Dahalan A’qilah A. , Saudi Azali , Sulaiman Jumat
Published: March 2022

Mobile robots are often in a situation where they need to find a bump-free path or navigation in their environment from any starting to a specific target point. Within this study, improving the navigation problem of a mobile robot iteratively by using a numerical method based on the potential field method is one of the main aims. This potential field will lean on the use of Laplace’s equation to restrain the formation of a potential function across regions within the mobile robot configuration area. The present paper proposed a Quarter-Sweep Modified Accelerated Overrelaxation (QSMAOR) approach to improve the pathfinding of mobile robots in a given environment. The experiment shows that, by using a finite difference method, it is capable of producing an optimal path and creating a smooth path between the starting and target point. The results of the simulation also show that this numerical approach works more rapidly and provides a smoother/clearer direction than the previous study.