bluuebunny/crossref_metadata_2025 huggingface dataset:
Public Health Policy: Legal Diferences in Formulation and Implementation
Authors: Catarino João Ricardo , Morais Nunes Alexandre , Sobral Susana
Published: July 2024

O ciclo de políticas públicas possui diversas fases. Contudo, em saúde, as fases mais sensíveis e que geram mais questões jurídicas são as da formulação e implementação. Assim, o presente estudo tem como objetivo compreender a importância e as diferenças jurídicas associadas às fases de formulação e implementação das políticas públicas de saúde em Portugal estabelecendo-se, sempre que possível, um paralelismo com o Brasil. Como método, recorre-se à revisão da literatura e à análise dos diplomas legais que regem a saúde em Portugal. Numa primeira fase aborda-se a questão teórica do ciclo das políticas públicas, numa segunda fase a questão concreta das diferenças jurídicas entre as fases de formulação e implementação na área da saúde e numa terceira fase o paralelismo com a realidade da política de saúde do Brasil. Concluímos que o ciclo de políticas públicas é dinâmico. Ainda que as fases analisadas tenham especificidades, acabam por se complementar, embora a implementação dependa dos meios financeiros disponíveis no Ministério da Saúde. Deste modo, esta fase pode conduzir a um processo incompleto ainda que possua pressupostos bem formulados na lei.
Mechanical Structure Design of Pressure Sensors With Temperature Self-Compensation for Invasive Blood Pressure Monitoring
Authors: Zhou Lianqiao , Li Qinlan , Xu Xinkai , Wei Shuang , Wang Shugang , Cui Jingqiang , Wang Guosheng , Liu Chong , Su Yewang
Published: July 2024

Invasive blood pressure (IBP) is a fundamental part of basic cardiovascular monitoring. Conventional piezoresistive pressure sensors are limited in usage due to the high cost associated with equipment and intricate fabrication processes. Meanwhile, low-cost strain gauge pressure sensors have poor performance in the gauge factor (GF) and temperature insensitivity. Here, we report a mechanical structure design for diaphragm pressure sensors (DPSs) by introducing a compensation grid to overcome the aforementioned challenges. A simplified model is established to analyze the mechanical deformation and obtain the optimal design parameters of the diaphragm pressure sensor (DPS). By rationally arranging the placement of sensitive grids to eliminate the discrepancy of relative resistance changes within four arms of the Wheatstone full-bridge circuit, the appropriate GF and high-temperature insensitivity are simultaneously achieved. The blood pressure sensor with the DPS is then fabricated and characterized experimentally, which demonstrates an appropriate GF (ΔU/U0)/P=3.56×10−5kPa−1 and low-temperature coefficient of voltage (ΔU/U0)/ΔT=3.4×10−7∘C−1. The developed mechanical structure design offers valuable insights for other resistive pressure sensors to improve the GF and temperature insensitivity.
An Intelligent Parameter Identification Algorithm of Linear Fuzzy Fractional Differential Equation
Authors: Dong Jun
Published: July 2024

The traditional linear generation fuzzy fractional differential equation parameter identification algorithm lacks the update of the parameter identification process, has a large amount of calculation, slow convergence speed of parameter identification, and strong dependence on initial values. In this paper, a new intelligent recognition algorithm for linearly generated fuzzy fractional differential equations is proposed. The parameters of the equation are re-expressed by the constant level set. The piecewise constant level set algorithm based on equation parameter intelligent identification is used to solve the steady-state solution of fractional differential equation, and the nonconvergence problem caused by too much calculation is solved. A new algorithm scheme for linearly generating fuzzy fractional differential equations is established, the constraints of the level set of the differential equations are calculated, and the updated algorithm for parameter identification of the equation is obtained. The evolutionary algorithm is used to solve the updating algorithm to realize the intelligent identification algorithm of linear fractional fuzzy differential equations. Experimental results showed that the algorithm had the advantages of fast convergence speed, high calculation accuracy, and low initial value.
Implementing Individually Tailored Prescription of Physical Activity in Routine Clinical Care: A Process Evaluation of the Physicians Implement Exercise = Medicine Project
Authors: Bouma Adrie J. , Nauta Joske , van Nassau Femke , Krops Leonie A. , van den Akker-Scheek Inge , Diercks Ron L. , de Groot Vincent , van der Leeden Marike , Leutscher Hans , Stevens Martin , van Twillert Sacha , Zwerver Hans , van der Woude Lucas H.V. , van Mechelen Willem , Verhagen Evert A.L.M. , van Keeken Helco G. , van der Ploeg Hidde P. , Dekker Rienk , _ _
Published: July 2024

Background: Although the prescription of physical activity in clinical care has been advocated worldwide, in the Netherlands, “Exercise is Medicine” (E = M) is not yet routinely implemented in clinical care. Methods: A set of implementation strategies was pilot implemented to test its feasibility for use in routine care by clinicians in 2 departments of a university medical center. An extensive learning process evaluation was performed, using structured mixed methods methodology, in accordance with the Reach, Effect, Adoption, Implementation, and Maintenance framework. Results: From 5 implementation strategies employed (education, E = M tool embedded in the electronic medical records, lifestyle coach situated within the department, overviews of referral options, and project support), the presence of adequate project support was a strong facilitator of the implementation of E = M. Also, the presence of the lifestyle coach within the department seemed essential for referral rate. Although clinicians appreciated the E = M tool, barriers hampered its use in practice. Conclusions: Specific implementation strategies, tailored to the setting, are effective in facilitating the implementation of E = M with specific regard to education for clinicians on E = M, deployment of a lifestyle coach within a department, and project coordination. Care providers do see a future for lifestyle coaches who are structurally embedded in the hospital, to whom they can easily refer.
Comparison of an Adaptive Ankle Brace to Conventional Taping for Rehabilitation of Acute Ankle Injury in Young Subelite Soccer Players: A Pilot Study
Authors: Krombholz Dirk , Willwacher Steffen , Consmüller Tobias , Linden Anna , Utku Burkay , Zendler Jessica
Published: July 2024

Context: Ankle sprains are a common injury in sports, for which use of external ankle support during rehabilitation has been suggested to improve clinical outcomes. Design: Cohort study. Methods: Thirteen soccer players experiencing acute lateral ankle sprain injury were provided a novel adaptive ankle brace or conventional ankle taping (control) as external ankle support throughout the injury rehabilitation process. All other clinical procedures were identical, and rehabilitation was supervised by the same team staff member. Time from injury to clearance to return to sport was tracked. Player experience with the ankle brace also was queried via electronic surveys. Results: The median time to return to sport was less for the Brace group (52.5 d) compared to the Control group (79.5 d), but the distributions of the 2 groups were not found to differ significantly (P = .109). Player surveys indicated they felt the brace to be comfortable or very comfortable, with better freedom of movement than other braces and the same freedom of movement as wearing no brace. All players reported wearing the brace to be the same or better experience as ankle taping. Discussion: These preliminary results indicate that the adaptive ankle brace is at least as effective as ankle taping for providing external support during the rehabilitation phase following acute lateral ankle sprain and suggest it may be a more effective ankle support solution in terms of patient compliance than conventional bracing or taping.
Intraindividual Correlation and Comparison of Maximal Aerobic Capacity and Maximum Power in Hand-Crank and Bicycle Spiroergometry
Authors: Schnadthorst Philipp Georg , Hoffmeister Meike , Grunwald Martina , Wagner Carl-Maximilian , Schulze Christoph
Published: July 2024

Background: Spiroergometry is important for modern performance diagnostics, and reference values have been evaluated for bicycle and treadmill ergometers. The aim of this study is to assess the comparability of bicycle and hand-crank spiroergometry and its associated parameters, as hand-crank spiroergometry can be used during rehabilitation in patients with definitive or temporally impairment of the lower extremity. Methods: Thirty-seven healthy volunteers completed 2 exhausting performance diagnostics on hand-crank and bicycle spiroergometry. Participants’ anthropometric characteristics, maximum power, multiple exertion criteria, maximum aerobic capacity, and maximum heart rate were detected, and ventilatory and metabolic thresholds were determined. Results: The maximum power, maximum heart rate, maximum aerobic capacity, and ventilatory thresholds were significant higher on the bicycle ergometer (P < .001). The metabolic thresholds occurred on higher lactate values on the hand-crank ergometer. Equations for calculating maximum aerobic capacity from the maximum power measured in either hand-crank or bicycle ergometer could be found through regression analysis. Conclusions: Although there are problems in interpreting results of different ergometries due to severe physiology differences, the equations can be used for patients who are temporally unable to complete the established ergometry due to a deficit in the lower extremity. This could improve training recommendations for patients and para-athletes in particular.
ATM and 53BP1 regulate alternative end joining–mediated V(D)J recombination
Authors: Wang Jinglong , Sadeghi Cheyenne A. , Le Long V. , Le Bouteiller Marie , Frock Richard L.
Published: July 2024

G
0
-G
1
phase alternative end joining (A-EJ) is a recently defined mutagenic pathway characterized by resected deletion and translocation joints that are predominantly direct and are distinguished from A-EJ in cycling cells that rely much more on microhomology-mediated end joining (MMEJ). Using chemical and genetic approaches, we systematically evaluate potential A-EJ factors and DNA damage response (DDR) genes to support this mechanism by mapping the repair fates of RAG1/2-initiated double-strand breaks in the context of Igκ locus V-J recombination and chromosome translocation. Our findings highlight a polymerase theta–independent Parp1-XRCC1/LigIII axis as central A-EJ components, supported by 53BP1 in the context of an Ataxia-telangiectasia mutated (ATM)–activated DDR. Mechanistically, we demonstrate varied changes in short-range resection, MMEJ, and translocation, imposed by compromising specific DDR activities, which include polymerase alpha, Ataxia-telangiectasia and Rad3-related (ATR), DNA2, and Mre11. This study advances our understanding of DNA damage repair within the 53BP1 regulatory domain and the RAG1/2 postcleavage complex.
Sea level controls on Ediacaran-Cambrian animal radiations
Authors: Bowyer Fred T. , Wood Rachel A. , Yilales Mariana
Published: July 2024

The drivers of Ediacaran-Cambrian metazoan radiations remain unclear, as does the fidelity of the record. We use a global age framework [580–510 million years (Ma) ago] to estimate changes in marine sedimentary rock volume and area, reconstructed biodiversity (mean genus richness), and sampling intensity, integrated with carbonate carbon isotopes (δ
13
C
carb
) and global redox data [carbonate Uranium isotopes (δ
238
U
carb
)]. Sampling intensity correlates with overall mean reconstructed biodiversity >535 Ma ago, while second-order (~10–80 Ma) global transgressive-regressive cycles controlled the distribution of different marine sedimentary rocks. The temporal distribution of the Avalon assemblage is partly controlled by the temporally and spatially limited record of deep-marine siliciclastic rocks. Each successive rise of metazoan morphogroups that define the Avalon, White Sea, and Cambrian assemblages appears to coincide with global shallow marine oxygenation events at δ
13
C
carb
maxima, which precede major sea level transgressions. While the record of biodiversity is biased, early metazoan radiations and oxygenation events are linked to major sea level cycles.
An unprecedented fall drought drives Dust Bowl–like losses associated with La Niña events in US wheat production
Authors: Zhang Lina , Zhao Haidong , Wan Nenghan , Bai Guihua , Kirkham M. B. , Nielsen-Gammon John W. , Avenson Thomas J. , Lollato Romulo , Sharda Vaishali , Ashworth Amanda , Gowda Prasanna H. , Lin Xiaomao
Published: July 2024

Unprecedented precipitation deficits in the 2022–2023 growing season across the primary wheat-producing region in the United States caused delays in winter wheat emergence and poor crop growth. Using an integrated approach, we quantitatively unraveled a 37% reduction in wheat production as being attributable to both per–harvested acre yield loss and severe crop abandonment, reminiscent of the Dust Bowl years in the 1930s. We used random forest machine learning and game theory analytics to show that the main driver of yield loss was spring drought, whereas fall drought dominated abandonment rates. Furthermore, results revealed, across the US winter wheat belt, the La Niña phase of the El Niño Southern Oscillation (ENSO), increased abandonment rates compared to the El Niño phase. These findings underscore the necessity of simultaneously addressing crop abandonment and yield decline to stabilize wheat production amid extreme climatic conditions and provide a holistic understanding of global-scale ENSO dynamics on wheat production.
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients
Authors: van den Berg Marloes , Shi Zhonghua , Claassen Wout J. , Hooijman Pleuni , Lewis Christopher T. A. , Andersen Jesper L. , van der Pijl Robbert J. , Bogaards Sylvia J. P. , Conijn Stefan , Peters Eva L. , Begthel Leon P. L. , Uijterwijk Bas , Lindqvist Johan , Langlais Paul R. , Girbes Armand R. J. , Stapel Sandra , Granzier Henk , Campbell Kenneth S. , Ma Weikang , Irving Thomas , Hwee Darren T. , Hartman James J. , Malik Fady I. , Paul Marinus , Beishuizen Albertus , Ochala Julien , Heunks Leo , Ottenheijm Coen A. C.
Published: July 2024

Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop contractile weakness of the diaphragm. Consequently, they may experience difficulty weaning from mechanical ventilation, which increases mortality and poses a high economic burden. Because of a lack of knowledge regarding the molecular changes in the diaphragm, no treatment is currently available to improve diaphragm contractility. We compared diaphragm biopsies from ventilated ICU patients (
N
= 54) to those of non-ICU patients undergoing thoracic surgery (
N
= 27). By integrating data from myofiber force measurements, x-ray diffraction experiments, and biochemical assays with clinical data, we found that in myofibers isolated from the diaphragm of ventilated ICU patients, myosin is trapped in an energy-sparing, super-relaxed state, which impairs the binding of myosin to actin during diaphragm contraction. Studies on quadriceps biopsies of ICU patients and on the diaphragm of previously healthy mechanically ventilated rats suggested that the super-relaxed myosins are specific to the diaphragm and not a result of critical illness. Exposing slow- and fast-twitch myofibers isolated from the diaphragm biopsies to small-molecule compounds activating troponin restored contractile force in vitro. These findings support the continued development of drugs that target sarcomere proteins to increase the calcium sensitivity of myofibers for the treatment of ICU-acquired diaphragm weakness.
MGA
deletion leads to Richter’s transformation by modulating mitochondrial OXPHOS
Authors: Iyer Prajish , Zhang Bo , Liu Tingting , Jin Meiling , Hart Kevyn , Zhang Jibin , Siegert Viola , Remke Marianne , Wang Xuesong , Yu Lei , Song Joo , Venkataraman Girish , Chan Wing C. , Jia Zhenyu , Buchner Maike , Siddiqi Tanya , Rosen Steven T. , Danilov Alexey , Wang Lili
Published: July 2024

Richter’s transformation (RT) is a progression of chronic lymphocytic leukemia (CLL) to aggressive lymphoma.
MGA
(
Max gene associated
), a functional MYC suppressor, is mutated at 3% in CLL and 36% in RT. However, genetic models and molecular mechanisms of
MGA
deletion that drive CLL to RT remain elusive. We established an RT mouse model by knockout of
Mga
in the
Sf3b1
/
Mdr
CLL model using CRISPR-Cas9 to determine the role of
Mga
in RT. Murine RT cells exhibited mitochondrial aberrations with elevated oxidative phosphorylation (OXPHOS). Through RNA sequencing and functional characterization, we identified
Nme1
(nucleoside diphosphate kinase) as an
Mga
target, which drives RT by modulating OXPHOS. Given that
NME1
is also a known MYC target without targetable compounds, we found that concurrent inhibition of MYC and electron transport chain complex II substantially prolongs the survival of RT mice in vivo. Our results suggest that the
Mga-Nme1
axis drives murine CLL-to-RT transition via modulating OXPHOS, highlighting a potential therapeutic avenue for RT.
Fibrobacter
sp. HC4, a newly isolated strain, demonstrates a high cellulolytic activity as revealed by enzymatic measurements and
in vitro
assay
Authors: Froidurot Alicia , Jacotot Emmanuel , Julliand Samy , Grimm Pauline , Julliand Véronique
Published: July 2024

Despite their low quantity and abundance, the cellulolytic bacteria that inhabit the equine large intestine are vital to their host, as they enable the crucial use of forage-based diets.
Fibrobacter succinogenes
is one of the most important intestinal cellulolytic bacteria. In this study,
Fibrobacter
sp. HC4, one cellulolytic strain newly isolated from the horse cecum, was characterized for its ability to utilize plant cell wall fibers.
Fibrobacter
sp. HC4 consumed only cellulose, cellobiose, and glucose and produced succinate and acetate in equal amounts. Among genes coding for CAZymes, 26% of the detected glycoside hydrolases (GHs) were involved in cellulolysis. These cellulases belong to the GH5, GH8, GH9, GH44, GH45, and GH51 families. Both carboxymethyl cellulase and xylanase activities of
Fibrobacter
sp. HC4 were detected using the Congo red method and were higher than those of
F. succinogenes
S85, the type strain. The
in vitro
addition of
Fibrobacter
sp. HC4 to a fecal microbial ecosystem of horses with large intestinal acidosis significantly enhanced fibrolytic activity as measured by the increase in gas and volatile fatty acids production during the first 48 h. According to this, the pH decreased and the disappearance of dry matter increased at a faster rate with
Fibrobacter
sp. HC4. Our data suggest a high specialization of the new strain in cellulose degradation. Such a strain could be of interest for future exploitation of its probiotic potential, which needs to be further determined by
in vivo
studies.

IMPORTANCE

Cellulose is the most abundant of plant cell wall fiber and can only be degraded by the large intestine microbiota, resulting in the production of volatile fatty acids that are essential for the host nutrition and health. Consequently, cellulolytic bacteria are of major importance to herbivores. However, these bacteria are challenged by various factors, such as high starch diets, which acidify the ecosystem and reduce their numbers and activity. This can lead to an imbalance in the gut microbiota and digestive problems such as colic, a major cause of mortality in horses. In this work, we characterized a newly isolated cellulolytic strain,
Fibrobacter
sp. HC4, from the equine intestinal microbiota. Due to its high cellulolytic capacity, reintroduction of this strain into an equine fecal ecosystem stimulates hay fermentation
in vitro
. Isolating and describing cellulolytic bacteria is a prerequisite for using them as probiotics to restore intestinal balance.
AI Methods in Control of Personalized General Education
Authors: Semenov A. L. , Abylkassymova A. E. , Rudchenko T. A.
Published: July 2024

The paper proposes a new approach to control the process of general education. Digital tools are used to form spaces of goals, tasks and learning activities, and to record the educational process of each student. Artificial intelligence tools are used when choosing a student’s personal goals and ways to achieve them, to make forecasts and recommendations to participants in the educational process. Big data from the entire education system and big linguistic models are used. The effects of the approach include ensuring the success of each student, objective assessment of the work of teachers and schools, and the adequacy of the succession process to higher education.
On the universality of integrable deformations of solutions of degenerate Riemann–Hilbert–Birkhoff problems
Authors: Cotti Giordano
Published: July 2024

This paper addresses the classification problem of integrable deformations of solutions of “degenerate” Riemann–Hilbert–Birkhoff (RHB) problems. These consist of those RHB problems whose initial datum has diagonal pole part with coalescing eigenvalues. On the one hand, according to theorems of [Formula: see text]Malgrange, Jimbo, Miwa, and Ueno, in the non-degenerate case, there exists a universal integrable deformation inducing (via a unique map) all other deformations [M. Jimbo, T. Miwa and K. Ueno, Monodromy preserving deformations of linear ordinary differential equations with rational coefficients I, Physica D 2 (1981) 306–352; B. Malgrange, Déformations de systèmes différentiels et microdifférentiels, in Séminaire E.N.S. Mathématique et Physique, eds. L. Boutet de Monvel, A. Douady and J.-L. Verdier, Progress in Mathematics, Vol. 37 (Birkhäuser, Basel, 1983), pp. 351–379; B.[Formula: see text]Malgrange, Sur les déformations isomonodromiques, II, in Séminaire E.N.S. Mathématique et Physique, eds. L. Boutet de Monvel, A. Douady and J.-L. Verdier, Progress in Mathematics, Vol. 37 (Birkhäuser, Basel, 1983), pp. 427–438; B. Malgrange, Deformations of differential systems, II, J. Ramanujan Math. Soc. 1 (1986) 3–15]. On the other hand, in the degenerate case, Sabbah proved, under sharp conditions, the existence of an integrable deformation of solutions, sharing many properties of the one constructed by Malgrange–Jimbo–Miwa–Ueno [C.[Formula: see text]Sabbah, Integrable deformations and degenerations of some irregular singularities, Publ. RIMS Kyoto Univ. 57(3–4) (2021) 755–794; arXiv:1711.08514v3 ]. Albeit the integrable deformation constructed by Sabbah is not, stricto sensu, universal, we prove that it satisfies a relative universal property. We show the existence and uniqueness of a maximal class of integrable deformations all induced (via a unique map) by Sabbah’s integrable deformation. Furthermore, we show that such a class is large enough to include all generic integrable deformations whose pole and deformation parts are locally holomorphically diagonalizable. In itinere, we also obtain a characterization of holomorphic matrix-valued maps which are locally holomorphically Jordanizable. This extends, to the case of several complex variables, already known results independently obtained by Thijsse and Wasow [Ph. G. A.[Formula: see text]Thijsse, Global holomorphic similarity to a Jordan form, Results Math. 8 (1985) 78–87; W.[Formula: see text]Wasow, Linear Turning Point Theory (Springer-Verlag, New York, 1985)].
Landscape Design of Memorial Garden Based on Computer Vision Communication and Realization by Visual Quality Prediction
Authors: Zhang Bei , Kang Xiaoting
Published: July 2024

This paper discusses the balance between artistry and science in the landscape design of memorial gardens, which relies on visual quality prediction. This paper introduces the theoretical basis of vision quality prediction, including the definition, evaluation method and prediction model of vision quality. This paper analyzes the artistry and scientificity of memorial garden landscape design. It expounds that artistry emphasizes the designer’s innovation and aesthetic expression, while scientificity focuses on the feasibility and practicability of design. Finding a balance between the two, so that the design can meet aesthetic and practical needs is an essential challenge for designers. The application of visual quality prediction in memorial garden landscape design and its influence on the balance between artistic and scientific design are discussed in detail. It is found that visual quality prediction can provide a scientific basis for designers to make decisions and help them create high-quality visual effects while meeting practical needs. The research results are summarized, and the future research direction is prospected. With the development of computer technology and artificial intelligence technology, visual quality prediction will play an increasingly important role in landscape design.
Impact of Climate-Related Financial Policy on Sustainable Development
Authors: Tran Minh Quang , Luu Hiep Ngoc , Luu Nguyen Hanh , Nguyen Minh Dinh , Phan Nguyen Thao Duc
Published: July 2024

This paper investigates the effectiveness of climate-related financial policies (CRFPs) in promoting sustainable development goals (SDGs). Using data from a sample of 71 countries between 2016 and 2021, we find robust evidence showing that CRFPs play a crucial role in assisting countries to achieve their sustainable development plans. However, the impact of CRFPs varies across different individual development goals. We find that CRFPs have the potential to foster food security, well-being, education quality, clean energy, innovation, decent work, innovation, equality, sustainable cities, marine life and peace. However, the CRFPs appear to hinder progress in responsible consumption and production as well as climate action. Our research further highlights the idea that institutional quality can act as a supporting mechanism to strengthen the positive impact of CRFPs on sustainable development in a country. Finally, we find that the implementation of CRFPs in advanced economies is more effective in promoting a country’s achievement of the SDGs. This study provides important policy implications of reinforcing institutional frameworks, fostering international partnerships and adopting holistic approaches that contribute to diverse facets of sustainable development.
Partial Motzkin paths with air pockets of the first kind avoiding peaks, valleys or double rises
Authors: Baril Jean-Luc , Ramírez José L.
Published: July 2024

Motzkin paths with air pockets (MAP) of the first kind are defined as a generalization of Dyck paths with air pockets. They are lattice paths in [Formula: see text] starting at the origin made of steps [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text], where two down-steps cannot be consecutive. We enumerate MAP and their prefixes avoiding peaks (respectively, valleys, respectively, double rise) according to the length, the type of the last step, and the height of its end-point. We express our results using Riordan arrays. Finally, we provide constructive bijections between these paths and restricted Dyck and Motzkin paths.
Data-driven PC-chair-in-the-loop Formation of Program Committees: An EDBT 2023 Experience
Authors: Bhowmick Sourav S , Hose Katja
Published: July 2024

The formation of a quality program committee (PC) for a conference venue is critical for a high-quality scientific program. Traditionally, PC chairs take a "manual" approach to form a PC. In practice, however, such an approach, might not create a diverse PC w.r.t. certain dimensions. Furthermore, it has been reported that the traditional manual approach may lead to dense coauthorship networks among PC members. All these aspects can easily make it challenging in practice to ensure fair and quality assignments of reviewers to submissions. In this article, we share our experiences and results of installing a novel data-driven PC-chair-inthe- loop PC formation framework for EDBT 2023 to mitigate some of the challenges brought by traditional PC formation methods.
GLOBEM: Cross-Dataset Generalization of Longitudinal Human Behavior Modeling
Authors: Xu Xuhai (Orson) , Liu Xin , Zhang Han , Wang Weichen , Nepal Subigya , Sefidgar Yasaman S. , Seo Woosuk , Kuehn Kevin S. , Huckins Jeremy F. , Morris Margaret E. , Nurius Paula S. , Riskin Eve A. , Patel Shwetak , Althoff Tim , Campbell Andrew T. , Dey Anind K. , Mankoff Jennifer
Published: July 2024

Ubiquitous computing, the seamless integration of sensing, analytics, and feedback into daily life envisioned by Weiser [12], has come closer to reality with the broad adoption of smartphones and wearable devices. These devices, integral to users' daily routines, passively collect massive amounts of data on human behavior, offering unprecedented insights into personal health and well-being [7]. For example, passive sensing can continuously monitor subtle changes in behavior indicative of depression or other shifts in mental health status [10,14,15].
Arctic Continental-Shelf Sediment Dynamics
Authors: Eidam Emily F. , Stark Nina , Nienhuis Jaap H. , Keogh Molly , Obelcz Jeff
Published: July 2024

Sediments covering Arctic continental shelves are uniquely impacted by ice processes. Delivery of sediments is generally limited to the summer, when rivers are ice free, permafrost bluffs are thawing, and sea ice is undergoing its seasonal retreat. Once delivered to the coastal zone, sediments follow complex pathways to their final depocenters—for example, fluvial sediments may experience enhanced seaward advection in the spring due to routing under nearshore sea ice; during the open-water season, boundary-layer transport may be altered by strong stratification in the ocean due to ice melt; during the fall storm season, sediments may be entrained into sea ice through the production of anchor ice and frazil; and in the winter, large ice keels more than 20 m tall plow the seafloor (sometimes to seabed depths of 1–2 m), creating a type of physical mixing that dwarfs the decimeter-scale mixing from bioturbation observed in lower-latitude shelf systems. This review summarizes the work done on subtidal sediment dynamics over the last 50 years in Arctic shelf systems backed by soft-sediment coastlines and suggests directions for future sediment studies in a changing Arctic. Reduced sea ice, increased wave energy, and increased sediment supply from bluffs (and possibly rivers) will likely alter marine sediment dynamics in the Arctic now and into the future.
Supraclavicular Irradiation Induces Lymphedema in Breast Cancer Patients Treated with Axillary Lymph Node Dissection and Taxane‐Containing Chemotherapy
Authors: Horisawa Nanae , Yoshimura Akiyo , Oze Isao , Sawaki Masataka , Hattori Masaya , Kotani Haruru , Kataoka Ayumi , Ozaki Yuri , Nozawa Kazuki , Endo Yuka , Takatsuka Daiki , Isogai Ayaka , Iwata Hiroji
Published: July 2024

Purpose. Breast cancer‐related lymphedema (LE) significantly impairs the patients’ quality of life. Axillary lymph node dissection (ALND) is a strong risk factor for LE in breast cancer surgery. In addition, postoperative administration of docetaxel (DTX) has been reported to be a risk factor for LE in patients who undergo ALND. Herein, we performed the risk of objective LE after ALND. Methods. Patients who visited the medical follow‐up clinic between 12 November 2018 and 11 January 2019 and at least one year postoperatively were eligible for this study. The risk factors for objective LE according to taxane‐containing regimen, radiation therapy, and body mass index and the effects of a taxane‐containing regimen followed by supraclavicular irradiation on LE were examined. Results. A total of 214 patients were included in this analysis, and objective LE was observed in 52 patients (24%). Univariate and multivariate analyses showed that only supraclavicular field irradiation was a statistically significant risk factor for objective LE. In addition, the sequential use of taxane‐containing regimens and supraclavicular RT was shown to be a more likely risk factor for LE than ALND alone. We also compared each taxane regimen with supraclavicular RT and found that DTX was more likely to be a risk factor for LE in cases of sequential use of supraclavicular RT than with ALND alone. However, when comparing DTX with supraclavicular RT and PTX with supraclavicular RT directly, there was no statistically significant difference in the risk of objective LE between the two groups. Conclusion. The risk for LE was more likely to be higher with the sequential use of taxane‐containing chemotherapy and supraclavicular field irradiation. Therefore, management of LE is important in these cases.
Enhancing Software Requirements Classification with Semisupervised GAN‐BERT Technique
Authors: Airlangga Gregorius
Published: July 2024

The field of automatic detection of quality attributes from software requirements’ text stands as one of the most pioneering realms within software requirements research. Such automatic quality attributes aim to aid stakeholders in establishing the system architecture and preemptively circumventing faults. A considerable number of classifier models have been put forward, many of which show encouraging results. However, our analysis has identified substantial gaps in these studies, including (a) a limited dataset volume, (b) the absence of an evaluation study for cross‐domain test sets, (c) the problem of real‐time prediction scenarios where a vast amount of unlabeled data floods the system each second, and (d) a dearth of comparative studies scrutinizing diverse software requirements datasets and multiple machine learning models, with particular emphasis on in‐domain and cross‐domain testing. Hence, there is a pressing need to construct an alternative framework to enhance classifier performance under such conditions. Our research is primarily centered on developing a semisupervised methodology that hinges on GAN‐BERT, introducing two datasets for the requirements of the engineering community and delivering comparative studies that consider a variety of classifiers and two labeling paradigms, namely, binary and multi. Remarkably, even with fewer data in a multiclassification scenario, our model outperforms other classifiers when assessing data from both identical and different domains.
Green Energy Production Aid Spider Robot: An Innovative Approach for Waste Separation Using Robotic Technology Powered with IoT
Authors: Paneru Biplov , Paneru Bishwash , Shah Krishna Bikram , Poudyal Ramhari , Poudyal Khem Narayan
Published: July 2024

Growing worldwide waste management challenges have prompted research efforts for sustainable solutions, especially in green energy technologies. This study highlights robotics’ critical role in modern waste management by putting forth a novel strategy incorporating cutting‐edge technologies. The research aims to create an effective waste monitoring system to measure the amounts of methane gas and organic waste at disposal sites. The main component of this method is a 3D‐printed spider robot driven by a servo motor with solid and flexible claws. This robotic system communicates gas level readings to the ThingSpeak platform on the Internet of Things, while it navigates waste disposal sites autonomously. The study also investigates how to develop robotic systems more economically and efficiently by using a portable, low‐power microcontroller, such as the Arduino Nano. The study uses a rigorous testing methodology to assess the performance and viability of the microcontroller and robotic system. The results are expected to emphasise a practical and economic development approach while offering insightful information on developing sustainable waste management technologies.
Quantitative Anatomical Study of the Supratentorial and Infratentorial “Endoscopic Keyhole” Approach to the Peripineal Region
Authors: Wu Hao , Maimaiti Aierpati , Xie Qiang , Aili Yirizhati , Muertizha Mamutijiang , Zhu Guohua , Mijiti Maimaitili , Li Yandong , Wang Yongxin
Published: July 2024

Background. The pineal region represents significant challenges in terms of neurosurgery. Currently, anatomical research that simulates surgery for the endoscopic keyhole approach to the pineal region is lacking. This study aims to summarize the exposure range and operational characteristics of total endoscopic surgery under the four supratentorial and infratentorial keyhole approaches, through rigorous quantitative anatomical research. We also aim to understand the surgical exposure characteristics and surgical feasibility under each approach. Method. Six wet cadaveric head specimens (a total of 12 sides) were subjected to simulated surgery with a keyhole bone window size of approximately 3 × 4 cm. The median endoscopic supracerebellar infratentorial approach (M‐ESCITA), the paramedian endoscopic supracerebellar infratentorial approach (PM‐ESCITA), the endoscopic occipital transtentorial approach (EOTA), and the endoscopic interhemispheric high occipital transtentorial approach (EHOTA) were used to measure the surgical path depth, maximum distance between the tentorial margins, maximum operable area, operable angle, and relative degree of freedom of each approach. Results. There was no difference in the exposure range of the surgical area. The surgical path of PM‐ESCITA was the longest (p < 0.001), and its horizontal operating angle was the largest (p < 0.001), whereas the anteroposterior operating angle of EHOTA was the largest (p < 0.001). The maximum operational area of M‐ESCITA was the largest in the pineal region (p < 0.01), whereas that of EHOTA was the largest in the tetrapod region (p < 0.001). M‐ESCITA had the highest relative degree of freedom during surgery at the pineal gland level (p < 0.001), PM‐ESCITA at the splenium of the corpus callosum (p < 0.01), and EHOTA at the corpora quadrigemina (p < 0.001). Conclusions. Each of the four endoscopic keyhole approaches has its own advantages. Through anatomical research, doctors can train themselves and master the differences in surgical procedures through different approaches. The choice of approach and surgical challenge are dependent on the microsurgical techniques employed by the surgeon. A balance between minimally invasive and safe endoscopic surgery should be pursued.
Single-Cell Profiling of Sarcomas from Archival Tissue Reveals Programs Associated with Resistance to Immune Checkpoint Blockade
Authors: Luthria Karan , Shah Parin , Caldwell Blake , Melms Johannes C. , Abuzaid Sinan , Jakubikova Viktoria , Brodtman D. Zack , Bose Sminu , Amin Amit Dipak , Ho Patricia , Biermann Jana , Tagore Somnath , Ingham Matthew , Schwartz Gary K. , Izar Benjamin
Published: July 2024

Purpose:

Sarcoma encompasses a diverse group of cancers that are typically resistant to current therapies, including immune checkpoint blockade (ICB), and underlying mechanisms are poorly understood. The contexture of sarcomas limits generation of high-quality data using cutting-edge molecular profiling methods, such as single-cell RNA-sequencing, thus hampering progress in understanding these understudied cancers.

Experimental Design:

Here, we demonstrate feasibility of producing multimodal single-cell genomics and whole-genome sequencing data from frozen tissues, profiling 75,716 cell transcriptomes of five undifferentiated pleomorphic sarcoma and three intimal sarcoma samples, including paired specimens from two patients treated with ICB.

Results:

We find that genomic diversity decreases in patients with response to ICB, and, in unbiased analyses, identify cancer cell programs associated with therapy resistance. Although interactions of tumor-infiltrating T lymphocytes within the tumor ecosystem increase in ICB responders, clonal expansion of CD8+ T cells alone was insufficient to predict drug responses.

Conclusions:

This study provides a framework for studying rare tumors and identifies salient and treatment-associated cancer cell intrinsic and tumor microenvironmental features in sarcomas.
Supplementary Figure S1 from CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma
Authors: Pal Sumanta K. , Tran Ben , Haanen John B.A.G. , Hurwitz Michael E. , Sacher Adrian , Tannir Nizar M. , Budde Lihua E. , Harrison Simon J. , Klobuch Sebastian , Patel Sagar S. , Meza Luis , Dequeant Mary-Lee , Ma Anna , He Qiuling Ally , Williams Leah M. , Keegan Alissa , Gurary Ellen B. , Dar Henia , Karnik Sushant , Guo Changan , Heath Heidi , Yuen Rachel R. , Morrow Phuong K. , Agarwal Neeraj , Srour Samer A.
Published: July 2024

Tumor biopsy CD70 H-scores
Supplementary Table S9 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Olink serum proteomic analysis
Supplementary Table S8 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

X50 High-parameter flow cytometry phenotypes and statistics
Supplementary Table S7 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Flow cytometry antibodies
Supplementary Table S6 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

List of MetaCyc pathways
Supplementary Table S5 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Disease control and objective response rates by Ruminococcaceae status
Supplementary Table S4 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Patients with continued response at time of study conclusion
Supplementary Table S3 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

All treatment-emergent adverse events
Supplementary Table S10 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Table of representativeness
Supplementary Table S1 from Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Authors: Glitza Isabella C. , Seo Yongwoo David , Spencer Christine N. , Wortman Jennifer R. , Burton Elizabeth M. , Alayli Farah A. , Loo Christopher P. , Gautam Shikha , Damania Ashish , Densmore Julie , Fairchild Justin , Cabanski Christopher R. , Wong Matthew C. , Peterson Christine B. , Weiner Brian , Hicks Nathan , Aunins John , McChalicher Christopher , Walsh Emily , Tetzlaff Michael T. , Hamid Omid , Ott Patrick A. , Boland Genevieve M. , Sullivan Ryan J. , Grossmann Kenneth F. , Ajami Nadim J. , LaVallee Theresa , Henn Matthew R. , Tawbi Hussein A. , Wargo Jennifer A.
Published: July 2024

Patient demographics