bluuebunny/crossref_metadata_2025 huggingface dataset:
O perfil somatotipo de atletas de voleibol masculino (infanto-juvenil e adulto) e as relações com a aptidão física: uma revisão sistemática
Authors: Braga Patrick , Porto Fernanda Errero
Published: May 2022

Atualmente o voleibol é a segunda modalidade esportiva mais praticada no Brasil, os atletas que praticam a modalidade para alcançar o alto rendimento, necessitam de altas demandas fisiológicas que determinam as características antropométricas e morfológicas dos atletas. A somatotipologia é uma metodologia utilizada pela ciência do esporte para classificação dos atletas, considerada método eficiente e de baixo custo que divide os atletas em três componentes (endomorfia, mesomorfia e ectomorfia). Desta forma, o presente estudo tem por objetivo investigar através da literatura se o somatotipo predominante nas categorias infanto-juvenis e adultos masculinos de voleibol e a influência sobre a aptidão física dos atletas. Metodologia: Realizou-se uma pesquisa bibliográfica nas bases de dados eletrônicas Bireme, Pubmed, SciELO e Google Acadêmico, considerando as publicações no período de 1999 a 2021. De um total de 138 estudos, 13 cumpriram os critérios de inclusão e exclusão e todos usaram o somatotipo além de outras variáveis antropométricas, a somatotipia predominante entre os adultos foi mesoectomorfo e na categoria infanto-juvenil ectomesomorfos, além disso, nenhum artigo realizou relação/correlação dos dados de somatotipo e perfil antropométrico com a aptidão física. Embora a caracterização do perfil somatotipo tenha sido utilizada em diversas modalidades esportivas tanto para classificação quanto seleção dos atletas, os estudos com a população infanto-juvenil e adulto masculino que praticam voleibol ainda são escassos.
Strategi Peningkatan Jumlah Sayuran Sawi Pada Musim Kemarau di Pasar Jagasatru Kota Cirebon Dengan Menggunakan Metode Analytical Hierarchy Process (AHP)
Authors: Asyifa Putri Nur , R. Eviyati R. Eviyati
Published: May 2022

Pasar Jagasatru merupakan pasar sentra sayur mayur terbesar di wilayah III Cirebon. Salah satu komoditas sayur yang disukai konsumen adalah sawi dan permasalahan yang dihadapi adalah sedikitnya persediaan sawi pada musim kemarau sehingga menyababkan harganya melonjak. Tujuan penelitian ini adalah untuk menentukan strategi peningkatan jumlah sayuran sawi pada musim kemarau. Penelitian dilaksanakan selama bulan Juli sampai November 2020. Metode penelitian ini adalah kuantitatif dengan teknik pendekatan survei. Populasi penelitian ini adalah pedagang sayur sawi yang berjumlah 13 orang sehingga teknik pengambilan sampel dilakukan secara sensus. Analisis data menggunakan Analytical Hierarchy Process (AHP). Hasil penelitian menyimpulkan bahwa strategi peningkatan sayuran sawi di Pasar Jagasatru adalah menambah jaringan pasokan sawi.Kata Kunci: Analytical Hierarchy Process, Cirebon, Pedagang, Pemasok, Sawi.
ANALISIS NILAI TAMBAH INDUSTRI RUMAH TANGGA PRODUK OLAHAN KERIPIK PISANG (Kasus Di Desa Bantaragung Kecamatan Sindang Wangi Kabupaten Majalengka)
Authors: Aufar Ghaisani Nurshabrina , Sukanata I Ketut
Published: May 2022

Penelitian ini bertujuan untuk mengetahui: (1) Besarnya biaya produksi, penerimaan, pendapatan, R/C Ratio, B/C Ratio dan BEP pada industru rumah tangga keripik pisang di Desa Bantaragung, (2) Nilai tambah pada industri rumah tangga keripik pisang di Desa Bantaragung. Penelitian dilaksanakan di Desa Bantaragung Kecamatan Sindang Wangi Kabupaten Majalengka pada Bulan Februari-Maret 2021, dengan 6 responden perajin keripik pisang yang dianalisis dalam satu kali produksi. Metode penelitian yang digunakan adalah sensus, dengan menggunakan kuesioner sebagai alat untuk mengetahui informasi perajin. Data dianalisis dengan menggunakan analisis kuantitatif. Metode analisis yang digunakan untuk menghitung nilai tambah industri rumah tangga keripik pisang Desa Bantaragung adalah metode hayami. Hasil penelitian ini menunjukan bahwa, dari 6 perajin industri rumah tangga keripik memberi nilai tambah (positif), dan usaha ini layak untuk dilaksanakan.Kata Kunci: Harga, Keripik Pisang, Majalengka, Metode Hayami, Nilai Tambah.
RELASI MEDIA, PEMERINTAH, DAN PUBLIK (ANALISIS FRAMING DAN STRUKTURASI PADA MAJALAH TEMPO)
Authors: Deha Daniel , Syas Mulharnetti
Published: May 2022

Penelitian ini bertujuan mengkaji relasi antara media, pemerintah, dan publik dalam pemberitaan Majalah Tempo tentang Revisi Undang-Undang (RUU) Nomor 32 Tahun 2002 tentang Komisi Pemberantasan Korupsi (KPK). Dengan menggunakan paradigma konstruktivis dan pendekatan deskriptif-kualitatif, peneliti membedah permasalahan penelitian ini melalui metode analisis teks framing model Robert N. Entman dan teori strukturasi Anthony Giddens. Hasil penelitian menunjukkan bahwa ada ketimpangan relasional dan struktural antara media, pemerintah, dan publik terkait RUU KPK. Pemerintah cenderung mereproduksi RUU KPK sebagai media kekuasaan dengan menggunakan sumber daya ekonomi dan politik untuk menciptakan struktur dominasi pada publik. Sementara media menyoroti secara tajam dominasi pemerintah dengan membeberkan sejumlah fakta dan argumentasi yang memperlihatkan kekeliruan pemerintah.Kata kunci: Framing; Media, pemerintah, dan publik; Relasi; Strukturasi
KOMUNIKASI PEMASARAN DALAM MENINGKATKAN KUNJUNGAN WISATAWAN (Studi Kasus pada Kelompok Penggerak Pariwisata (Kompepar) Kabupaten Kuningan)
Authors: Fransisca Maria
Published: May 2022

Penelitian ini bertujuan mendeskripsikan Komunikasi Pemasaran Dalam Meningkatkan Kunjungan Wisatawan (Studi Kasus: Kelompok Penggerak Pariwisata (Kompepar) Kabupaten Kuningan serta faktor-faktor apa saja yang mendukung dan menghambat komunikasi pemasaran tersebut. Diharapkan dapat memberikan informasi kepada pihak yang memberikan perhatian terhadap dunia kepariwisataan dan perkembangannya Penelitian ini menggunakan metode deskriptif kualitatif dengan 3 (tiga) informan. Hasil penelitian menunjukkan bahwa bahwa komunikasi pemasaran yang dilakukan oleh Kompepar meliputi bauran pemasaran yaitu periklanan, promosi penjualan, Humas, pemasaran langsung, pemasaran mulut ke mulut dan acara dalam memasarkan Desa Wisata Cibuntu dapat meningkatkan kunjungan wisatawan yang datang ke Desa Wisata Cibuntu namun hanya untuk wisatawan nusantara saja, lain halnya dengan wisatawan mancanagera yang jarang berkunjung ke Desa Wisata Cibuntu. Adapun faktor pendukung komunikasi pemasaran yang dilakukan yaitu tingginya potensi wisata, adanya dukungan dari pemerintah daerah, pengoptimalan teknologi informasi, upaya peningkatan fasilitas dan Infrastruktur. Sementara faktor penghambatnya yaitu keterbatasan dana, minimnya signal telepon, kurangnya SDM. Kemudian upaya dalam mengatasi hambatan komunikasi pemasaran tersebut adalah dengan menjalin hubungan kerjasama dengan Sekolah Tinggi Pariwisata (STP) Trisakti, dan memohon permintaan didirikan menara signal telepon kepada pemerintah.Kata-kata Kunci: Komunikasi Pemasaran, Kelompok Penggerak Pariwisata, Desa Wisata
STRATEGI PROGRAMMING ACQUISITION DALAM KELANCARAN OPERASIONAL PENYIARAN PROGRAM TELEVISI
Authors: Ingratubun Adrian
Published: May 2022

Media televisi sejauh ini merupakan media massa yang menjadi sarana pemenuhan waktu luang. dan telah menjadi alat pemasaran yang efektif. Makin banyak audience, makin tinggi rate (harga) slot iklan, makin tinggi pendapatan, dan makin tinggi keuntungannya. Singkatnya, tidak ada penonton, tidak ada iklan, tidak ada keuntungan, tidak ada penyiaran. Programming Acquisition adalah bagian yang bertugas merencanakan, memilih, dan menyusun acara. Membuat rencana siaran, berarti membuat konsep acara yang akan disuguhkan kepada audien. Jika suatu program bisa menarik audiens dan program itu memiliki karakteristik yang sesuai dengan kebutuhan pemasang iklan untuk mempromosikan produknya, maka media penyiaran bersangkutan mendapatkan pemasang iklan dan mendapatkan pemasukan. Dengan demikian, pendapatan dan prospeksuatu media penyiaran sangat ditentukan oleh bagian program Management dimana fungsi utama programming dirumuskan sebagai bagian memproduksi dan membeli atau akuisisi program yang dapat menarik audien yang dituju; menyusun jadwal penayangan program atau skedulling program untuk menarik audien yang diinginkan; memproduksi layanan publik dan promosi serta produksi iklan lokal; produksi dan akuisisi program-program lainnya untuk memuaskan ketertarikan publik; dan menciptakan keuntungan bagi pemilik media penyiaran. Untuk itu dalam merencanakan program acara televisi selalu memperhatikan etika media massa yang merupakan etika penyiaran.Kata Kunci: Strategi, Programming, Acquisition, Televisi.
KETERBUKAAN KOMUNIKASI VERTIKAL DAN HORIZONTAL DENGAN MENGUSUNG KOMUNIKASI ORGANISASI DI KLINIK SPESIALIS JANTUNG CIREBON
Authors: Andriany Dian
Published: May 2022

Komunikasi sejatinya tak akan pernah lepas dari kehidupan manusia sejak lahir. Sejak dalam kandungan komunikasi sudah dimulai terjalin antara ibu dan calon bayi melalui asupan makanan yang masuk lewat plasenta. Setelah bayi terlahir di dunia, orang tua selalu menjalin komunikasi dengan bayinya hingga tumbuh dewasa. Demikian pula ketika terjun dalam dunia pekerjaan seperti di klinik spesialis jantung cirebon, mau tidak mau akan ada komunikasi yang terjalin sesama warga dalam perusahaan tersebut. Karena pentingnya komunikasi dengan warga perusahaan adalah hal yang tidak dapat dipungkiri. Namun kenyataannya selalu terdapat pimpinan perusahaan atau warga perusahaan yang tidak terbuka lebar untuk berkomunikasi dalam organisasi. Selain itu terdapat pula warga perusahaan yang segan mengeluarkan ide atau sarannya. Dalam penulisan karya ilmiah ini penulis berusaha memaparkan keterbukaan komunikasi vertikal dan horizontal dalam organisasi. Karena komunikasi merupakan unsur terpenting dalam memajukan visi dan misi organisasi. Untuk mencapai tujuan organisasi, atasan dengan bawahan serta sesama bawahan harus saling mendukung satu sama lain caranya dengan komunikasi. Komunikasi yang efektif dapat terwujud jika ada keterbukaan.Kata Kunci: Komunikasi Vertikal, Komunikasi Horizontal, Komunikasi Organisasi, Spesialis Spesial Jantung, Cirebon
The Undifferentiation of Mimetic Violence: From Oedipus to COVID-19
Authors: Gebauer Gunter
Published: May 2022

In the Poetics Aristotle limited the concept of mimesis to the aesthetic relationship between drama and the actions of its mythical models. In the 1970s, having found representations of mimetic relationships in the myths themselves, René Girard argued that they are the cause of a violence that disrupts the mythical communities from within. Later, Girard extended the concept of mimesis to natural processes: By destroying the differences between model and imitation mimetic processes in nature and in the social world unleash violence. In this essay two important examples of dedifferentiation are discussed and compared: Sophocles’ Oedipus dramas and the COVID-19 pandemic crisis in our present time. In both examples, successive mimetic processes subvert the natural and economic foundations of the state, and primarily its framework of rights and duties. The pandemic process destroys the biological, political, and social systems of differences and gives rise to fights for domination over the state.
Between Mask and Uniform: The Undecidability of Mimesis
Authors: Belo Sara
Published: May 2022

In this essay I address the problem of identity formation posed by our mimetic condition by considering the relationship between art, domination, and liberation. To better understand how the artistic gift can engender liberation, even if permanently at risk of being instrumentalised for domination, I propose an analysis of the differences between an artistic mask and a uniform. More specifically, I focus on how each of these mimetic forms mobilise different kinds of actions due to the different conceptions of identity that underlie them: the temporary result of an instance of identification among many others, in the case of the artistic mask, and a permanent stabilisation, in the case of the uniform. I ground this differentiation in an analysis of the film Der Hauptmann (2018) by Robert Schwentke and on readings of Philippe Lacoue-Labarthe and Jean-Luc Nancy’s critique of ‘ The Nazi Myth’ (1990) constitutive of the mimetic turn.
A review of the research in teaching and learning the negative numbers: an “action research” concerning the application of the geometrical model of the number line
Authors: Gagatsis Athanasios , Alexandrou Maria
Published: May 2022

The notion of negative numbers is one of the most fundamental in mathematics. For many years, they have caused confusion and they have been an object of controversy among great researchers, until the development of symbolic algebra led to their acceptance in the form they have today. When students are first introduced to the concept of negative numbers and the operations between them, various difficulties occur and misconceptions arise, as expected. Their comprehension is one of the most challenging tasks of teaching mathematics due to their complexity and abstract nature. For this purpose, various models have been devised and employed. In the present study we expose some of the epistemological obstacles commonly observed in understanding negative numbers and then exhibit and compare two different models frequently used for introducing the four basic operations between them.
Fare scuola a casa in tempi di lockdown: l’esempio dei problemi moltiplicativi
Authors: Maffia Andrea
Published: May 2022

Attraverso due studi di caso, si propone una riflessione sull’attività matematica individuale che i bambini della scuola primaria svolgono a casa e su come l’interazione con i genitori influenzi tale attività. Dopo aver presentato una breve rassegna della letteratura sul tema del “fare scuola a casa” e del rapporto dei genitori con i compiti di matematica dei figli, si analizzano qualitativamente dati raccolti durante il lockdown e relativi a due studenti di classe terza della scuola primaria italiana.
Kritik-Analitik Düşünme Eğilimlerini Ölçmeye Yönelik Bütüncül, Basit ve Kapsayıcı Bir Test Önerisi
Authors: Makaracı Murat
Published: May 2022

Bazı gelişmiş ülkelerin eğitim ve istihdam süreçlerinde Eleştirel Düşünme ve/veya Analitik Düşünme becerileri ölçülmektedir. Batıda kabul görmüş ve yaygın olarak kullanılan bazı testler Watson-Glaser Eleştirel Düşünme Ölçeği, Cornell Eleştirel Düşünme Testi, Kaliforniya Eleştirel Düşünme Eğilimi Ölçeği gibi testlerdir. Bu çalışmamızda eleştirel düşünme standartları içerisinde sağlıklı düşünmeyi geliştirme ve daha iyi kararlar almaya yönelik düşünceler kritik edilmiş ve 22 sorudan oluşan bir test önerisi sunulmuştur. Her bir soru 0-5 arası puanlama usulü ile 110 maksimum puan olacak şekilde tasarlanmıştır. 0-22 düşük seviye, 23-44 zayıf seviye, 45-66 orta seviye, 67-88 iyi seviye, 89-110 ileri seviye olarak derecelendirilmiştir. Bir düşünme semineri sonunda yaklaşık 120 katılımcıya (kadın-erkek, 16-65 yaş aralığı, ilkokul-üniversite mezunu) test sorularının cevaplanması istenmiş, cevaplama bittikten sonra objektiflik için puanlama usulü açıklanarak kendi kendilerini puanlamaları istenmiştir. Örnekleme yoluyla rastgele seçilen kişilerden puanlarını grup ile paylaşan 2 kişi orta, 2 kişi iyi ve 1 kişi ileri seviye çıkmıştır. Testin temel amaçları; düşüncelerin kontrolünün ele alınması, iç görü kazanma, akıllı seçimler yapma, kendini kandırma veya kontrolden çıkmış duyguların neden olduğu kötü düşünme alışkanlıklarının keşfedilmesi, gerçekten ne istediğimizin netleştirilmesi, neyi bilmediğimizin farkına varılması, doğru soruların sorulması, reklamcılar, politikacılara kanmama, beyin yıkamaya, manipülasyona ve ikiyüzlülüğe karşı çıkabilme becerisi, endişelenme, konformizm ve suçlama eğiliminin farkında olunmasıdır. Ölçek geliştirilmesi için faktör analizi yapılarak, Kaiser-Meyer-Olkin KMO ve Barlett Test Cronbach Alpha katsayılarının belirlenmesi önerilmektedir.
Küresel Toplumlarda Zihniyet Tasarımı ve Kültürel Zeka/İrfan’ın Analizi
Authors: ATAMAN Kemal Yavuz
Published: May 2022

Toplumlar küreselleşmekte, çok kültürlü yapılara dönüşmekte, küreselleşme ise toplumları değiştirmektedir. İnsanlık, teknolojinin sağladığı imkanlarla, iletişim, etkileşim yoluyla gelişmektedir. Gelişmeyle beraber küresel sistem, yeryüzünün varlıklarını, kaynaklarını, inanç, düşünce ve sosyo-kültürel yapılarını baskı altına almakta, değerler üzerinde tekel oluşturmakta, sömürmekte, hatta imha etmektedir. Yaratılışa, varoluşa uygun toplumsal yapıların kurulması, yaşaması, sürdürülmesi gerekir. Küreselleşme gerçeğini dikkate alarak toplumsal düzeni sağlam, sürekli kılacak “Zihniyet Tasarımı” insanlığın ortak, zorunlu ihtiyacıdır. Tasarım, her şeyin dikkate alınarak özenle yapılması, benimsenmesidir. Zihniyet Tasarımı’nın Kültürel Zeka ile düşünülmesi, programlanması, kurgulanması hayata yansıması gerekir, çok önemlidir. Kültürel Zeka küreselleşmenin zorunlu kıldığı, muhtaç olduğu bir düşünme eylemidir. İnsanlık, çok kültürlü, çok hukuklu, çok kimlikli olarak birlikte yaşamanın, çoklu aidiyetin olağan hale geldiği ciddi bir dönemden, süreçten geçmektedir. Farklılıkların anlaşılması, hissedilmesi, yönetilmesi, eşit, adil, insaflı bir anlayışın tasarımıyla, “Kültürel Zeka” maharetiyle mümkündür. Kültürel Zeka küresel şirketler ve çok kültürlü işletmelerde IQ ve EQ yanında, bilim adamlarının, yöneticilerin uyguladığı son zamanların yükselen, önemli bir yönetim aracıdır
Benralizumab in Patients With Severe Eosinophilic Asthma With and Without Chronic Rhinosinusitis With Nasal Polyps: An ANANKE Study post-hoc Analysis
Authors: D'Amato Maria , Menzella Francesco , Altieri Elena , Bargagli Elena , Bracciale Pietro , Brussino Luisa , Caiaffa Maria Filomena , Canonica Giorgio Walter , Caruso Cristiano , Centanni Stefano , De Michele Fausto , Di Marco Fabiano , Pastorello Elide Anna , Pelaia Girolamo , Rogliani Paola , Romagnoli Micaela , Schino Pietro , Senna Gianenrico , Vultaggio Alessandra , Ori Alessandra , Simoni Lucia , Boarino Silvia , Vitiello Gianfranco , Aliani Maria , Del Giacco Stefano
Published: May 2022

Background

Severe eosinophilic asthma (SEA) in the presence of chronic rhinosinusitis with nasal polyps (CRSwNP) indicates the presence of a more extensive eosinophilic inflammation. Post-hoc analyses from a pivotal clinical trial have demonstrated the enhanced efficacy of benralizumab on asthma outcomes in patients with CRSwNP as a comorbidity.

Methods

This is a post-hoc analysis from the Italian multi-center observational retrospective ANANKE study. Patients were divided into two groups based on self-reported CRSwNP. Baseline clinical and laboratory features in the 12 months prior to benralizumab prescription were collected. Data of change over time of blood eosinophils, annualized exacerbations rates (AER), asthma control, lung function, oral corticosteroids (OCS) use, and benralizumab discontinuation were collected during the observation period.

Results

At baseline, the 110 patients with CRSwNP were less frequently female (50.9% vs 74.2%) and obese (9.1% vs. 22.6%) with higher eosinophils (605 vs. 500 cells/mm3) and OCS use when compared to patients without CRSwNP. Similar reductions of AER were seen (-95.8% vs. −91.5% for any exacerbation and −99.1% vs. −92.2% for severe exacerbations in patients with and without CRSwNP, respectively). During benralizumab treatment, comorbid SEA+CRSwNP was associated with a lower risk of any exacerbation (p = 0.0017) and severe exacerbations (p = 0.025). After a mean ± SD exposure of 10.3 ± 5.0 months, half of the SEA+CRSwNP patients eliminated OCS use. No discontinuation for safety reasons was recorded.

Conclusions

This study helped to confirm the baseline clinical features that distinguish patients with and without CRSwNP being prescribed benralizumab. Numerically enhanced OCS reduction and lower exacerbation risk were observed in patients with SEA and comorbid CRSwNP treated with benralizumab.
A Strategic Review on Carbon Quantum Dots for Cancer-Diagnostics and Treatment
Authors: Naik Kaustubh , Chaudhary Shilpi , Ye Lei , Parmar Avanish Singh
Published: May 2022

The understanding of the genesis of life-threatening cancer and its invasion calls for urgent development of novel technologies for real-time observations, early diagnosis, and treatment. Quantum dots (QDs) grabbed the spotlight in oncology owing to their excellent photostability, bright fluorescence, high biocompatibility, good electrical and chemical stability with minimum invasiveness. Recently, carbon QDs (CQDs) have become popular over toxic inorganic QDs in the area of bioimaging, biosensing, and drug delivery. Further, CQDs derived from natural sources like biomolecules and medicinal plants have drawn attention because of their one-pot, low-cost and ease of synthesis, along with remarkable tunable optical properties and biocompatibility. This review introduces the synthesis and properties of CQDs derived from natural sources, focusing on the applicability of CQD-based technologies as nano-theranostics for the diagnosis and treatment of cancer. Furthermore, the current issues and future directions for the transformation of CQDs-based nanotechnologies to clinical applications are highlighted.
Can Clinical Outcomes Be Improved, and Inpatient Length of Stay Reduced for Adults With Diabetes? A Systematic Review
Authors: Friel Kathleen Michelle , McCauley Claire , O’Kane Maurice , McCann Michael , Delaney Geraldine , Coates Vivien
Published: May 2022

Aim

To examine the efficacy of clinical practice strategies in improving clinical outcomes and reducing length of hospital stay for inpatients with Type 1 and Type 2 diabetes.

Background

People living with diabetes are at increased risk of being admitted to hospital and to stay in hospital longer than those who do not have the condition. Diabetes and its complications cause substantial economic loss to those living with the condition, their families, to health systems and national economies through direct medical costs and loss of work and wages. Length of stay is a major factor driving up hospitalisation costs relating to those with Type 1 and Type 2 diabetes with suboptimal blood glucose management, hypoglycaemia, hyperglycaemia, and co-morbidities shown to considerably impact upon length of stay. The identification of attainable evidence-based clinical practice strategies is necessary to inform the knowledge base and identify service improvement opportunities that could lead to improved clinical outcomes for these patients.

Study Design

A systematic review and narrative synthesis.

Methods

A systematic search of CINAHL, Medline Ovid, and Web of Science databases was carried out to identify research papers reporting on interventions that have reduced length of hospital stay for inpatients living with diabetes for the period 2010–2021. Selected papers were reviewed, and relevant data extracted by three authors. Eighteen empirical studies were included.

Results

Eighteen studies spanned the themes of clinical management innovations, clinical education programmes, multidisciplinary collaborative care and technology facilitated monitoring. The studies demonstrated improvements in healthcare outcomes such as glycaemic control, greater confidence with insulin administration and reduced occurrences of hypoglycaemia and hyperglycaemia and decreased length of hospital stay and healthcare costs.

Conclusions

The clinical practice strategies identified in this review contribute to the evidence base for inpatient care and treatment outcomes. The implementation of evidence-based research can improve clinical practice and show that appropriate management can enhance clinical outcomes for the inpatient with diabetes, potentially leading to reductions in length of stay. Investment in and commissioning of practices that have the potential to afford clinical benefits and reduce length of hospital stay could influence the future of diabetes care.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=204825, identifier 204825.
Green Solvents for Lipid Extraction From Microalgae to Produce Biodiesel
Authors: Liu Xiaofang , Yu Dayong , Luo Hangyu , Li Can
Published: May 2022

Microalgae are considered as the third-generation feedstock for biodiesel production, and lipid extraction plays a significant role in efficient production of biofuels. Numerous technologies including chemical, mechanical, and biological have been achieved but high efficiency and potential application on an industrial scale are still needed. This review discusses the factors that influence biodiesel quality and the relative green and sustainable solvents for lipid extraction.
Risk Communication During COVID-19 Pandemic: Impacting Women in Bangladesh
Authors: Ahmed Nova , Rony Rahat Jahangir , Sinha Anik , Ahmed Md. Sabbir , Saha Anik , Khan Syeda Shabnam , Abeer Ifti Azad , Amir Shajnush , Fuad Tanvir Hasan
Published: May 2022

Risk communication during COVID-19 is essential to have support, but it is challenging in developing countries due to a lack of communication setup. It is more difficult for the low-income, marginal communities, and specifically, women in developing countries. To understand this, particularly during the COVID-19 pandemic, we conducted a qualitative study among N = 37 women (urban 20, rural = 17) across Bangladesh that presents the risk communication factors related to social and financial challenges. It reveals that the majority of the urban communities lack communication with local authorities, where urban low-income communities are the worst sufferers. Due to that, the majority of the urban participants could not get financial support, whereas the rural participants received such support for having communications with local authorities during the pandemic. However, access to technology helped some participants share and receive pandemic-related information about risk communication, and the adoption of financial technology helped to get emergency financial support through risk communication. Moreover, this work is expected to understand the role of risk communication during the COVID-19 pandemic among women in Bangladesh.
Psychological Literacy and Undergraduate Psychology Education: An International Provocation
Authors: Cranney Jacquelyn , Dunn Dana S. , Hulme Julie A. , Nolan Susan A. , Morris Sue , Norris Kimberley
Published: May 2022

For over 50 years, psychology leaders have called for fundamental changes in how we undertake research, education, and community interaction. This paper provocatively argues the case for “why now, and how.” The COVID-19 pandemic demonstrated that psychology must contribute more to the wellbeing of local and global communities. We propose that a primary mechanism for doing so is by reinventing the undergraduate psychology program. This paper provides a stimulus to initiate international discussion of interconnected graduate capabilities, which we propose to be: Knowledge, Research Methods, Application of Knowledge to Personal, Professional and Community (Local, National, Global) Domains, Values and Ethics, Critical Thinking, Communication, and Cultural Responsiveness. Focusing on core aspects of psychology (Knowledge, Research Methods, Application) and more generic but evidence-informed capabilities is a unique formulation and should well serve graduates, employers, society, and the psychology discipline and profession in the uncertain “post-pandemic” era. We also propose psychological literacy as a promising unifying approach for psychology. Finally, we provide a “road-map” for curriculum renewal at international, national, and institutional levels, involving a consensus-seeking process (an extensive scholarly overview of the proposed capabilities is provided).
Enhancing School Effectiveness by Implementing Identified and Intrinsic Motivation Among Primary School Teachers
Authors: Khun-Inkeeree Hareesol , Yusof Mat Rahimi , Maruf Irma Rachmawati , Mat Tuan Roslina Tuan , Sofian Fatimah Noor Rashidah Mohd
Published: May 2022

Teacher job motivation is one of the factors that influence school effectiveness. The success of a school can be seen in the achievement of outstanding results and the absence of disciplinary difficulties. As a result, this research was carried out with the aim of identifying the dimensions that affect teachers’ job motivation and school effectiveness in Pasir Mas District Excellence Cluster Primary School, Kelantan. A cross-sectional sampling approach was used in this report, with a questionnaire distributed to 146 teachers from four primary schools in the Pasir Mas district. The data were analyzed using SEM-PLS indicate that the motivational dimensions and intrinsic dimensions for teacher job motivation independent variables are predictors of school effectiveness contingent variables in Pasir Mas District Excellence Cluster Primary School. The study’s implications show that teacher job motivation is significant in attempts to increase school effectiveness. Teachers now play an important part in education by improving the effectiveness of teaching and learning in classrooms. This is seen as very important to maximize student achievement as well as increase the effectiveness of the school because excellent and high -performing students are the result of an effective institution.
The Dibenzyl Isoquinoline Alkaloid Berbamine Ameliorates Osteoporosis by Inhibiting Bone Resorption
Authors: Zhang Chongjing , Zhong Zeyuan , Sang Weicong , Ghorbani Farnaz , Ghalandari Behafarid , Mohamadali Marjan , Irani Shiva , Qian Zhi , Yi Chengqing , Yu Baoqing
Published: May 2022

Postmenopausal osteoporosis (PMOP) is a kind of primary osteoporosis that is characterized by decreased bone density and strength. Berbamine is a nonbasic quaternary benzylisoquinoline plant alkaloid that has been widely used in the clinic to treat leukopenia in China. We found that berbamine inhibited RANKL-induced osteoclastogenesis of bone marrow-derived macrophages (BMMs) in vitro, which mainly occurred in the middle phase and late phase. The gene and protein expression levels of osteoclast-related molecules, including CTSK, MMP-9, NFATc1, CD44 and DC-STAMP, were also downregulated by berbamine. In vivo, we treated PMOP mice with berbamine for 8 weeks and found that the extent of osteoporosis was alleviated significantly according to micro-CT scanning, hematoxylin-eosin staining, DC-STAMP immunohistochemical staining and TRAP immunohistochemical staining in the distal femurs of the mice. Our findings demonstrate that berbamine has an inhibitory effect on the osteoclastogenesis of BMMs and can prevent bone loss after ovariectomy in vivo. This study provides evidence that berbamine is a potential drug for the prevention and treatment of PMOP.
Phenological Coadaptation Can Stabilize Predator–Prey Dynamics
Authors: Mougi Akihiko
Published: May 2022

In recent years, phenology – the seasonal timing of biological life cycles – has received increasing attention as climate change threatens to shift phenology. Phenology is crucial to the life cycle of organisms and their interactions with intimate partner species; hence, phenology has important fitness consequences suggesting that phenology can change through adaptive processes caused by species interaction. However, to date, there is limited understanding of how phenological adaptation occurs among interacting species and consequently affects ecological population dynamics. In this study, a phenological predator–prey co-adaptation model was evaluated to determine how adaptive phenological changes occur in prey and predator and how phenological coadaptation affects their coexistence. Population fluctuations tend to decrease and become stabilized when adaptation occurs rapidly. Furthermore, when adaptation is slow, predator–prey dynamics can be stabilized or destabilized depending on the initial difference in phenological timing between species. These results suggest that phenology shaped by slow coevolution can shift with changes in activity timing caused by environmental changes and simultaneously alter the stability of predator–prey dynamics. In contrast, phenology caused by rapid adaptation, such as phenotypic plasticity, may be robust to environmental change and maintain the stability of predator–prey dynamics. Understanding the types of adaptative processes that shape species phenologies may be crucial for predicting the ecological effects of climate change.
Assessment of Sectoral Virtual Water Flows and Future Water Requirement in Agriculture Under SSP-RCP Scenarios: Reflections for Water Resources Management in Zhangye City
Authors: Wang Yifei , Wu Haowei , Li Zhihui
Published: May 2022

Water scarcity is a core issue that constraints the high-quality development of arid areas in northwestern China. Zhangye is an oasis city located in the Heihe River Basin in northwestern China. It is populated with an agriculture-dominated economy and faces more and more serious water crises. Virtual water is an indicator that can measure the embodied water in the traded products, which has been widely applied for making rational policies for water resources management. In addition, clarifying water requirements in agricultural sectors under future climate change scenarios is essential to develop more appropriate adaptation strategies. From this perspective, this study aims to evaluate and compare virtual water flows among various sectors in Zhangye for the years 2012 and 2017 with a single regional input-output model and to further clarify the future water requirement tendency in agriculture during 2020–2050 under different shared socioeconomic pathways and representative concentration pathways (SSP-RCP) scenarios. The results showed that the planting sector directly contributed most of the total water consumption with the highest direct coefficient of 3307.5 m3/yuan in 2012, whereas the manufacture of food products and tobacco processing sector had the largest proportion of indirect water consumption (99%) mainly from intermediate inputs of agricultural products. Water consumption intensity of all sectors on average decreased by 22% during 2012–2017, indicating an increasing water utilization efficiency in economic industries. Household consumption also can improve water utilization efficiency as the major pathway for final consumption (86.4% in 2017). Water scarcity in Zhangye was becoming increasingly prominent since virtual water net exports were higher than local consumption, especially in the agriculture, manufacturing, and energy supply industries. Moreover, under climate change scenarios, we found the highest level of water requirement per unit area occurred in 2000, but it still had an incremental potential by 2050, especially in SSP585. The high requirement intensity and large-scale maize planting caused a rising tendency of total crop water requirement with an annual increasing rate of 8.4% from 1980 to 2050. This makes it possible to adapt to climate change through scientific management measures and technical means. We further made policy implications for adaptive management of water resources in Zhangye.
A Potential Indicator ARRDC2 Has Feasibility to Evaluate Prognosis and Immune Microenvironment in Ovarian Cancer
Authors: Zhang Mengjun , Liu Yunduo , Liu Yuan , Hou Siyu , Li Hao , Ma Ying , Wang Can , Chen Xiuwei
Published: May 2022

Background: The abnormal expression of α-arrestin protein family plays a key regulatory role in the occurrence and development of many cancers, including colorectal cancer and cervical cancer, and is inseparable from changes in the tumor immune microenvironment. However, the role of ARRDC2, an important member of this family, in the malignant biological process of ovarian cancer (OC) has not been reported, and its role in the change of the immune microenvironment is also unknown.

Methods: In this study, HPA, TCGA, GEO and other databases were used to explore the role of ARRDC2 in the prognosis assessment of ovarian cancer. Then, GO, KEGG analysis and GSEA analysis of the biological processes and cell signaling pathways that ARRDC2 may be involved in activated or inhibited. In addition, the TIMER and TISIDB database were used to conduct in-depth research on the role of ARRDC2 in the change of the immune microenvironment of ovarian cancer. The CMap database explored and screened drugs that may be used for treatment. Through cell transfection, CCK-8, Ki-67 immunofluorescence, wound healing, transwell and clone formation assay, the effect of ARRDC2 knockdown on the malignant biological behavior of OC cells were explored.

Results: There were significant differences between OC and ARRDC2 mRNA and protein levels. High ARRDC2 expression level is associated with poor overall survival and can be used as an independent prognostic factor. Interestingly, ARRDC2 expression is positively correlated with B cells, Neutrophils, Dendritic cells and CD8+ T cells, signifying that ARRDC2 may be related to infiltration of immune cells. ARRDC2 and its co-expressed genes are enriched in cell signaling pathways related to the immune system. We explored two possible drugs for the treatment of ovarian cancer. Finally, the results of in vitro experiments indicated that knockdown of ARRDC2 may inhibit malignant phenotypes such as proliferation and migration of OC cells.

Conclusion: The differentially expressed ARRDC2 may be a potential prognostic indicator and can be used as a novel biomarker for exploring the immune microenvironment of ovarian cancer.
Comprehensive Analysis of Programmed Cell Death Signature in the Prognosis, Tumor Microenvironment and Drug Sensitivity in Lung Adenocarcinoma
Authors: Pan Shize , Meng Heng , Fan Tao , Hao Bo , Song Congkuan , Li Donghang , Li Ning , Geng Qing
Published: May 2022

Programmed cell death (PCD) is a process that regulates the homeostasis of cells in the body, and it plays an important role in tumor immunity. However, the expression profile and clinical characteristics of PCD-related genes remain unclear. In this study, we comprehensively analysed the PCD genes with the tumor microenvironment (TME), drug sensitivity, immunothearapy response, and evaluated their prognostic value through systematic bioinformatics methods.We identified 125 PCD-related regulatory factors, which were expressed differently in lung adenocarcinoma (LUAD) and normal lung tissues. 32 PCD related prognostic genes associated with LUAD were identified by univariate Cox analysis. 23 PCD-related gene signature was constructed, and all LUAD patients in the Cancer Genome Atlas (TCGA) dataset were stratified as low-risk or high-risk groups according to the risk score. This signature had a powerful prognostic value, which was validated in three independent data sets and clinical subtypes. Additionally, it has unique properties in TME. Further analysis showed that different risk groups have different immune cell infiltration, immune inflammation profile, immune pathways, and immune subtypes. In addition, the low-risk group had a better immunotherapy response with higher levels of multiple immune checkpoints and lower Tumor immune dysfunction and exclusion (TIDE) score, while the high-risk group was sensitive to multiple chemotherapeutic drugs because of its lower IC50. In short, this is the first model to predict the prognosis and immunological status of LUAD patients based on PCD-related genes. It may be used as a predictor of immunotherapy response to achieve customized treatment of LUAD.
Chromosome-Scale, Haplotype-Resolved Genome Assembly of Non-Sex-Reversal Females of Swamp Eel Using High-Fidelity Long Reads and Hi-C Data
Authors: Tian Hai-Feng , Hu Qiaomu , Lu Hong-Yi , Li Zhong
Published: May 2022

The Asian swamp eel (Monopterus albus) is an excellent model species for studying sex change and chromosome evolution. M. albus is also widely reared in East Asia and South-East Asia because of its great nutritional value. The low fecundity of this species (about 300 eggs per fish) greatly hinders fries production and breeding programs. Interestingly, about 3–5% of the eels could remain as females for 3 years and lay more than 3,000 eggs per fish, which are referred to as non-sex-reversal (NSR) females. Here, we presented a new chromosome-level genome assembly of such NSR females using Illumina, HiFi, and Hi-C sequencing technologies. The new assembly (Mal.V2_NSR) is 838.39 Mb in length, and the N50 of the contigs is 49.8 Mb. Compared with the previous assembly obtained using the continuous long-read sequencing technology (Mal.V1_CLR), we found a remarkable increase of continuity in the new assembly Mal.V2_NSR with a 20-times longer contig N50. Chromosomes 2 and 12 were assembled into a single contig, respectively. Meanwhile, two highly contiguous haplotype assemblies were also obtained, with contig N50 being 14.54 and 12.13 Mb, respectively. BUSCO and Merqury analyses indicate completeness and high accuracy of these three assemblies. A comparative genomic analysis revealed substantial structural variations (SVs) between Mal.V2_NSR and Mal.V1_CLR and two phased haplotype assemblies, as well as whole chromosome fusion events when compared with the zig-zag eel. Additionally, our newly obtained assembly provides a genomic view of sex-related genes and a complete landscape of the MHC genes. Therefore, these high-quality genome assemblies would provide great help for future breeding works of the swamp eel, and it is a valuable new reference for genetic and genomic studies of this species.
The Hypothiocyanite and Amantadine Combination Treatment Prevents Lethal Influenza A Virus Infection in Mice
Authors: Ashtiwi Nuha Milad , Sarr Demba , Nagy Tamás , Reneer Z. Beau , Tripp Ralph A. , Rada Balázs
Published: May 2022

The influenza virus has a large clinical burden and is associated with significant mortality and morbidity. The development of effective drugs for the treatment or prevention of influenza is important in order to reduce its impact. Adamantanes and neuraminidase inhibitors are two classes of anti-influenza drugs in which resistance has developed; thus, there is an urgent need to explore new therapeutic options. Boosting antiviral innate immune mechanisms in the airways represents an attractive approach. Hypothiocyanite (OSCN−) is produced by the airway epithelium and is effective in reducing the replication of several influenza A virus strains in vitro. It remains, however, largely unexplored whether OSCN− has such an antiviral effect in vivo. Here we determined the therapeutic potential of OSCN−, alone or in combination with amantadine (AMT), in preventing lethal influenza A virus replication in mice and in vitro. Mice intranasally infected with a lethal dose of A/Puerto Rico/8/1934 (H1N1) or A/Hong Kong/8/1968 (H3N2) were cured by the combination treatment of OSCN− and AMT. Monotherapy with OSCN− or AMT alone did not substantially improve survival outcomes. However, AMT+OSCN− treatment significantly inhibited viral replication, and in vitro treatment inhibited viral entry and nuclear transport of different influenza A virus strains (H1N1 and H3N2) including the AMT-resistant strain A/WSN/33 (H1N1). A triple combination treatment consisting of AMT, oseltamivir, and OSCN− was also tested and further inhibited in vitro viral replication of the AMT-resistant A/WSN/33 strain. These results suggest that OSCN− is a promising anti-influenza treatment option when combined with other antiviral drugs.
Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/β-Catenin Signaling Pathway
Authors: Noack Laurens , Bundkirchen Katrin , Xu Baolin , Gylstorff Severin , Zhou Yuzhuo , Köhler Kernt , Jantaree Phatcharida , Neunaber Claudia , Nowak Aleksander J. , Relja Borna
Published: May 2022

Background

Trauma is the third leading cause of mortality worldwide. Upon admission, up to 50% of traumatized patients are acutely intoxicated with alcohol, which might lead to aberrant immune responses. An excessive and uncontrolled inflammatory response to injury is associated with damage to trauma-distant organs. We hypothesize that, along with inflammation-induced apoptosis, the activation of the Wnt/β-catenin signaling pathway would cause breakdown of the lung barrier and the development of lung injury after trauma. It remains unclear whether ethanol intoxication (EI) prior to trauma and hemorrhagic shock will attenuate inflammation and organ injury.

Methods

In this study, 14 male C57BL/6J mice were randomly assigned to two groups and exposed either to EtOH or to NaCl as a control by an oral gavage before receiving a femur fracture (Fx) and hemorrhagic shock, followed by resuscitation (THFx). Fourteen sham animals received either EtOH or NaCl and underwent surgical procedures without THFx induction. After 24 h, oil red O staining of fatty vacuoles in the liver was performed. Histological lung injury score (LIS) was assessed to analyze the trauma-induced RLI. Gene expression ofCxcl1,Il-1β,Muc5ac,Tnf, andTnfrsf10bas well as CXCL1, IL-1β, and TNF protein levels in the lung tissue and bronchoalveolar lavage fluid were determined by RT-qPCR, ELISA, and immunohistological analyses. Infiltrating polymorphonuclear leukocytes (PMNLs) were examinedviaimmunostaining. Apoptosis was detected by activated caspase-3 expression in the lung tissue. To confirm active Wnt signaling after trauma, gene expression ofWnt3aand its inhibitor sclerostin (Sost) was determined. Protein expression of A20 and RIPK4 as possible modulators of the Wnt signaling pathway was analyzedviaimmunofluorescence.

Results

Significant fatty changes in the liver confirmed the acute EI. Histopathology and decreasedMuc5acexpression revealed an increased lung barrier breakdown and concomitant lung injury after THFx versus sham. EI prior trauma decreased lung injury. THFx increased not only the gene expression of pro-inflammatory markers but also the pulmonary infiltration with PMNL and apoptosis versus sham, while EI prior to THFx reduced those changes significantly. EI increased the THFx-reduced gene expression ofSostand reduced the THFx-induced expression ofWnt3a. While A20, RIPK4, and membranous β-catenin were significantly reduced after trauma, they were enhanced upon EI.

Conclusion

These findings suggest that acute EI alleviates the uncontrolled inflammatory response and lung barrier breakdown after trauma by suppressing the Wnt/β-catenin signaling pathway.
Comprehensive Profiling Reveals Prognostic and Immunogenic Characteristics of Necroptosis in Soft Tissue Sarcomas
Authors: Qi Lin , Xu Ruiling , Ren Xiaolei , Zhang Wenchao , Yang Zhimin , Tu Chao , Li Zhihong
Published: May 2022

Soft tissue sarcomas (STSs) are heterogeneous malignancies derived from mesenchymal cells. Due to its rarity, heterogeneity, and limited overall response to chemotherapy, STSs represent a therapeutic challenge. Necroptosis is a novel therapeutic strategy for enhancing immunotherapy of cancer. Nevertheless, no research has explored the relationship between necroptosis-related genes (NRGs) and STSs. In this study, differentially expressed NRGs were identified using The Cancer Genome Atlas (TCGA) and The Cancer Genotype-Tissue Expression (GTEx) project. The expression levels of 34 NRGs were significantly different. Several key NRGs were validated using RT-qPCR and our own sequencing data. Patients with STSs were divided into two clusters using consensus cluster analysis, and significant differences were observed in their survival (p=0.002). We found the differentially expressed genes (DEGs) between the two clusters and carried out subsequent analysis. The necroptosis-related gene signatures with 10 key DEGs were identified with a risk score constructed. The prognosis of TCGA-SARC cohort with low necroptosis-related risk score was better (p<0.001). Meanwhile, the low-risk group had a significantly increased immune infiltration. Using the data of GSE17118 and another immunotherapy cohort as external validations, we observed significant survival differences between the two risk groups (p=0.019). The necroptosis-related risk score proved to be an independent prognostic factor, and a nomogram was further established and integrated with other clinical features. Notably, the necroptosis-related gene signature could also act as the prognostic indicator in other malignancies based on pan-cancer analysis. In summary, the study outlines NRGs in STSs and their potential role in prognosis and will be one of the important directions for future research.