bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing and combining chimeric antigen receptors for improved cellular immunotherapy of hematological malignancies
Authors:   , Roex Gils
Published: September 2024

Cancer remains the primary cause of premature death in the world. Hematological malignancies collectively account for 1.27 million of those cases, of which the large majority are of B-cell origin. Despite significant therapeutic advancements over the past decades, many patients still experience relapse and treatment resistance. Chimeric antigen receptor (CAR-)T-cell therapy, in which T cells are armored with a synthetic tumor-specific receptor, has been able to provide hope for many of these patients. The first part of this thesis provides the rationale behind and development of a multi-target CAR therapy for B-cell malignancies. We summarize the clinical outcomes of pivotal trials of the most advanced CD19 and BCMA CAR-T-cell products that led to the commercial approval of several CAR-T-cell products. Moreover, a meta-analysis was performed on clinical efficacy and safety data of BCMA CAR-T cells. We discovered that both patient and product characteristics had a notable impact on therapeutic potency and safety. These findings could support the design of future BCMA CAR-T-cell products and clinical trials. Unfortunately, our analysis also highlighted the lack of a plateau in progression-free survival curves of BCMA CAR-T-cell therapy, highlighting the need for additional or different interventions. For this reason, we investigated a BCMA/CD19 dual-CAR strategy to overcome antigen escape. As product quality, and manufacturing cost and length of autologous CAR-T cells are suboptimal, we chose to use the FDA-approved NK-92 cell line as a homogeneous, readily available cell source to test our dual-CAR strategy. we demonstrated efficient production of off-the-shelf BCMA/CD19 dual-CAR NK-92 that show potency against antigen escape tumor models. The second part of the thesis explores the modular design of CARs. This modularity theoretically allows quasi-infinite combinations of CAR domains, yet CARs currently used in the clinic are composed of only a handful of components. Hypothesis-driven, low throughput exploration of novel domains is resource-intensive and time-consuming. Existing high throughput workflows largely focusses on antigen binding domains and costimulatory domains, leaving a large knowledge gap on structural domains such as the hinge domain. Therefore, we show the preliminary development of bulk and arrayed screens of medium-size CAR hinge domain libraries. We believe that the combination of these methodologies will expand our understanding of structural and functional properties of the hinge domain. The development of these high throughput screens is expected to ultimately facilitate rational design of novel CAR therapies.
The Role of Managers in Employee Job Satisfaction Considering Multiple Mediating Effects
Authors: Aliyari Mahdi
Published: September 2024

In today's world, the critical and highly effective role of industry in economic development is undeniable. Industrial managers also play a crucial role, making it important to examine their management styles and status concerning employee job satisfaction and ultimately the economy of society. Job satisfaction is a significant factor in career success and contributes to increased efficiency and personal fulfillment. This study aims to investigate the role of managers in job satisfaction due to multiple mediating effects. The necessary data for the research were collected through a survey. The study population consisted of employees of Isfahan's Mobarakeh Steel Company, from which 300 individuals were selected for the study using Cochran's formula and random sampling. The research hypotheses were examined using Amose21 and SPSS software. The findings indicate that the manager's role has a positive and significant impact on colleague relationships, as well as on aspects of well-being and job promotion. Additionally, the results showed a direct and moderate effect on work conditions, duties, and processes. This study contributes to understanding the role of managers in job satisfaction by clarifying interactions between five dimensions of job satisfaction and highlighting the connection between management styles that lead to organizational growth and job satisfaction.
STRATEGI PENGEMBANGAN LAYANAN ADMINISTRASI KEMAHASISWAAN
Authors: Elizah Tenti , Hamengkubuwono Hamengkubuwono , Harahap Emmi Kholilah
Published: September 2024

This research aimed to explore the strategies for developing student administrative services at IAIN Curup and the contributing factors to these services' development. This case study involved administrative staff, students, and institutional leaders at IAIN Curup, recruited using purposive sampling methods. Data collection was conducted through interviews and observations and analyzed using an interactive model. Key findings of the research emphasized crucial indicators for enhancing student administrative services. Response time was prioritized by implementing flexible staff scheduling, enhancing information systems, and conducting periodic evaluations. Improvements in information accessibility were achieved through data standardization and optimization of digital access. Queue reduction was addressed through process engineering, staff augmentation, and effective dissemination of queue information. Quality of service was enhanced by satisfaction surveys, feedback analysis, and benchmarking practices. Integration of information systems involved comprehensive evaluations, data protection measures, and system maintenance. Enhancements in communication quality were realized through channel reviews, ensuring transparency, advancing technology, and providing staff training. Supporting the development of these services were institutional management support, investments in information technology, human resource training, interdepartmental cooperation, student involvement in improvements, and a commitment to continuous enhancement. Future research should extend these findings to different higher education contexts to validate the results.
IMPLEMENTASI METODE WAFA DALAM MENINGKATKAN HASIL BELAJAR TAHSIN DAN TAHFIDZ
Authors: Nurkhalizah Ervin , Akil Akil , Susanto Agus
Published: September 2024

The aim of this research is to find out how the Wafa Method is used to teach Tahsin and Tahfidz Al-Qur'an at SMPIT Harapan Umat Karawang. Another aim of this research is to find out how well the results of learning to read the Koran using tajwid rules are. This research uses a qualitative approach, which allows further explanation of the problem to be studied naturally. Researchers considered the idea of the Wafa method, which seeks to help students read the Qur'an. To collect and obtain data, researchers use methods such as observation, interviews, and documentation. Qualitative-descriptive analysis is used to process data. This data comes from documentation, interviews and observations carried out by researchers both before and after the implementation of the learning. According to the results of data analysis, research using the Wafa Method in Improving Tahsin and Tahfidz Learning Outcomes at SMPIT Harapan Umat Karawang really requires careful and systematic planning, implementation and supervision/evaluation. The Wafa method has proven effective in improving tahsin and tahfidz learning outcomes at SMPIT Harapan Umat Karawang. This can be seen from student achievement, ability to read and write the Al-Qur'an, memorize the Al-Qur'an, as well as motivation, student interest in the Al-Qur'an and the achievement of tahsin tahfidz learning results can be seen from the students' grades and tasnif results. at SMPIT Harapan Umat Karawang.
El proyecto europeo a examen: de la antesala de parís a la elaboración del texto lisboeta
Authors: Saldaña Ortega Virginia
Published: September 2024

La presente obra centra sus esfuerzos en analizar las relaciones entre la Unión Europea y la CELAC desde tres frentes: jurídico, económico y político-social. Los desafíos que está viviendo el mundo actual necesitan de respuestas solventes por parte de los Estados, siendo insuficientes, a juicio de los autores, las respuestas dadas en el marco de la soberanía nacional, y revelándose como esenciales las acciones derivadas de la toma de decisiones supranacional. En este contexto tan convulso, los autores y autoras de la obra entienden que, tanto la integración europea, como la integración latinoamericana, resultan trascendentales para que ambas regiones puedan ganar cada vez más peso a fin de contrarrestar a las grandes potencias: EEUU, China o Rusia. Además, la perspectiva coincidente en señalar que la alianza estrecha entre la Unión Europea y América Latina no solamente es deseable (dados los vínculos culturales entre ambas regiones) sino necesaria para construir un orden mundial basado en normas consensuadas, el respeto a los derechos humanos, el fomento de los sistemas democráticos y la confrontación de resurgimientos populistas que nos retrotraen a amargas épocas del pasado, debe dar paso a un futuro entendimiento euro latinoamericano que trascienda los temas que históricamente se han venido tratando en las diversas cumbres. Sin lugar a dudas, la reunión de 2025 en Colombia puede ser un paso decisivo en este camino.
Integración eurolatinoamericana: entre la democracia y el terror
Authors: Velázquez Baquerizo Ernesto
Published: September 2024

La presente obra centra sus esfuerzos en analizar las relaciones entre la Unión Europea y la CELAC desde tres frentes: jurídico, económico y político-social. Los desafíos que está viviendo el mundo actual necesitan de respuestas solventes por parte de los Estados, siendo insuficientes, a juicio de los autores, las respuestas dadas en el marco de la soberanía nacional, y revelándose como esenciales las acciones derivadas de la toma de decisiones supranacional. En este contexto tan convulso, los autores y autoras de la obra entienden que, tanto la integración europea, como la integración latinoamericana, resultan trascendentales para que ambas regiones puedan ganar cada vez más peso a fin de contrarrestar a las grandes potencias: EEUU, China o Rusia. Además, la perspectiva coincidente en señalar que la alianza estrecha entre la Unión Europea y América Latina no solamente es deseable (dados los vínculos culturales entre ambas regiones) sino necesaria para construir un orden mundial basado en normas consensuadas, el respeto a los derechos humanos, el fomento de los sistemas democráticos y la confrontación de resurgimientos populistas que nos retrotraen a amargas épocas del pasado, debe dar paso a un futuro entendimiento euro latinoamericano que trascienda los temas que históricamente se han venido tratando en las diversas cumbres. Sin lugar a dudas, la reunión de 2025 en Colombia puede ser un paso decisivo en este camino.
Expert System for Determining Diseases and Pests in Seaweed Using Forward Chaining (Case Study : Watorumbe Village, Mawasangka Tengah)
Authors: Asriani Ika , Muchtar Mutmainnah , Ismail Rima Ruktiari , Paliling Alders , Sya'ban Kharis , Karim Rahmat
Published: September 2024

Seaweed is a marine organism that plays a crucial role in both ecosystem and economy. However, it often faces attacks from diseases and pests that can jeopardize the productivity and sustainability of the seaweed industry. Hence, the development of an expert system to diagnose seaweed diseases and pests becomes imperative. This research aims to develop an Expert System for Determining Diseases and Pests in Seaweed using the Forward Chaining method, with a case study conducted in the Watorumbe Village, Mawasangka Tengah Sub-district, Southeast Sulawesi. The Forward Chaining method is employed to identify symptoms appearing in seaweed and determine potential diseases or pests. Testing is carried out with 30 data samples compared against expert diagnoses, resulting in an accuracy rate of 90%. Therefore, this system has the potential to assist seaweed farmers in diagnosing diseases and pests more quickly and accurately, thereby enhancing the productivity and sustainability of seaweed cultivation efforts.
Comparative Analysis of Google Vision OCR with Tesseract on Newspaper Text Recognition
Authors: Prakisya Nurcahya Pradana Taufik , Kusmanto Bintang Timur , Hatta Puspanda
Published: September 2024

Optical Character Recognition (OCR) is a technique used to convert image files into machine-readable text. There are two Optical Character Recognition (OCR) algorithms that are currently well known and widely used, namely Google Vision's Optical Character Recognition (OCR) and Tesseract. The purpose of this study is to compare the Optical Character Recognition (OCR) algorithms of Google Vision and Tesseract so that people can more easily find out which algorithm is the right one to implement on the system they are going to build. The method used in this research is Research and Development (R&D) with the stages of literature study, needs analysis, dataset collection and expansion, architectural design development and application modeling, system implementation, testing and evaluation, drawing conclusions. To be able to determine the level of accuracy, precision and sensitivity of each algorithm, this research uses the Confusion Matrix formula. The results of this study conclude that Google Vision's Optical Character Recognition (OCR) algorithm is superior to Tesseract because the level of accuracy, sensitivity, and precision is superior to Google Vision.
Enhanced Laptop Recommendation System Using Tsukamoto Fuzzy Logic
Authors: Nasrullah Asmaul Husnah , Adiba Fhatiah , Anastasia Tezza , Farghina Syakira Ayma , Akbar Muh.
Published: September 2024

One of the most popular and rapidly growing needs among the general public is laptops. Currently, there are many types of laptops with varying features, and not everyone knows the advantages and disadvantages of each type. The purpose of this research is to develop and build a Fuzzy inference system that applies the Tsukamoto method. This is to address issues in providing unclear or inaccurate services to customers during the laptop sales process. By developing a recommendation system that can provide guidance or suggestions in purchasing a laptop based on interest and needs in searching for references, and the type of laptop that meets the criteria. The decision to purchase a laptop uses parameters such as screen size, RAM capacity, SSD capacity, and price. The implementation of the Fuzzy Tsukamoto method for providing laptop purchase recommendations is able to give good recommendations.
ACHIEVING GENDER EQUALITY AND WOMEN LEADERSHIP IN A SELECTED STATE UNIVERSITY IN ZIMBABWE: A FEMINIST CAPABILITIES APPROACH
Authors:   Department of Educational Policy Studies and Leadership Midlands State University, Moyo Annah , Muchabaiwa Wonder ,   Department of Educational Policy Studies and Leadership Midlands State University
Published: September 2024

Despite international efforts towards gender equality, universities in developing countries including Zimbabwe continue to grapple with underrepresentation of women in leadership positions. The glass ceiling remains an impediment for women in universities in developing countries. This study explores the lived experiences and perspectives of female leaders and prospective female leaders in Zimbabwean state universities. The study adopts the feminist capability lens to illuminate the complexities and nuances of challenges that obstruct female academics to assume leadership positions. This qualitative study adopted a sequential exploratory design and collected data through in-depth interviews, focus group discussions and document reviews selected state universities. The findings highlight the deeply entrenched cultural values gender stereotypes that continue to disproportionally disadvantage prospective female leaders in universities. Such stereotypes include belief in mancho masculine attributes for leaders, women’s domestic responsibilities and lack of support and role models. The findings highlight the need for targeted interventions, including policy changes, leadership development programs, and initiatives to address work-life balance and support prospective female leaders. This study thus contributes to the ongoing discourse on gender equality in higher education, offering valuable insights for policymakers, university administrators, and scholars working towards a more inclusive future for African universities.
INEQUALIRY, ONLINE TEACHING AND QUALITY EDUCATION, “EXCLUDING THE EXCLUDED” IN INSTITUTIONS OF HIGHER LEANING IN ZIMBABWE: HOW TO BUILD INCLUSIVE INSTITUTIONS?
Authors:   Midlands State University Research fellow Gender Institute, Winniefridah Matsa , Lesley Matsa ,   Institute of Sustainable Project Planning Monitoring and Evaluation ICT networker in the Academic Affairs Department, Mhlanga Songile ,   Midlands State University Director Disability Resource Centre, Lecturer, Itayi Mariko ,   Midlands State University Director Disability Resource Centre
Published: September 2024

The covid pandemic has been marked by negative outcomes locally, regionally and globally. The sudden closure of institutions of learning, copious teaching and learning dynamics emerged giving rise to dire demand for blended learning. The study explores the intersection of gender, socio-economic status, disability as well as online learning and how this impacted on vulnerable learners’ access to quality education during the pandemic and its aftermath. The paper was framed within the exclusion and social justice theoretical frameworks. The design was phenomenological, focusing on the lived experiences of vulnerable female, orphans, those living with disabilities and learners from low socio-economic status. Midlands State University and the vulnerable groups were purposively sampled. Key university informants were officers from information and technology services, the library, Quality Assurance and Professional Development, Disability Resource Centre, student affairs division respectively giving a total of 5 key informants. Focus group discussions were held with 6 orphans from child headed households, 5 male and 7 female students from low socio-economic status from both rural and urban areas and 14 students living with differing disabilities, giving a total of 32 participants. Selection from other vulnerable students beside those living with disabilities was based on voluntariness and the need for a gender matrix. Online teaching and learning created a digital access gap with the most vulnerable experiencing various types of exclusions. To achieve effective teaching and learning, the paper recommends inclusive pedagogies and sustainable learning frameworks that allow the achievement of SDG 4on equitable and inclusive education
COMPETÊNCIAS DE LIDERANÇA E GERAÇÕES: UM ESTUDO SOBRE EMPREENDEDORES DO SETOR ALIMENTÍCIO
Authors: Garcia Eduarda Tavares , Dornelas Myriam Angélica , Valadão Danielle Nunes , Terra Juliano Mendonça
Published: September 2024

O objetivo geral deste estudo foi identificar as competências de liderança, sob a ótica de empreendedores de diferentes gerações, para empresas do ramo alimentício de um município de Minas Gerais. Metodologicamente, foi realizada uma pesquisa exploratória, de caráter descritivo, cuja coleta de dados se deu mediante aplicação de questionário semiestruturado aos empreendedores (sócios proprietários) de 18 empresas cadastradas na Associação Industrial e Comercial. A análise dos dados foi realizada pela técnica de análise de conteúdo. Obteve-se que as gerações participantes do estudo foram os Baby Boomers, geração X e geração Y. O perfil típico dos empreendedores do segmento alimentício pertenceu às Gerações Baby Boomers, X e Y; sexo masculino; possui ensino superior completo; proprietário da empresa; principal tomador de decisão; e entre 15 e 20 anos atuando em sua empresa. Os resultados da análise sobre as competências de liderança indicaram que a maioria dos representantes da geração Boomers deste estudo não são flexíveis. Das competências que divergem totalmente da teoria, tem-se apenas a autoconfiança. Pode-se concluir que as competências de liderança foram afetadas por diferenças entre as gerações e as mais afetadas, na visão dos respondentes, foram: autoconfiança, capacidade de trabalhar em equipe, capacidade de se comunicar e criatividade.
O EIXO MICROBIOTA-INTESTINO-CÉREBRO E SUA INFLUÊNCIA NAS DOENÇAS NEURODEGENERATIVAS: UMA REVISÃO INTEGRATIVA
Authors: Ferreira Gabriela , Michels Vittoria Eidam , Matiusso Camila
Published: September 2024

The microbiota of the digestive system is made up of a wide range of microorganisms, including bacteria, fungi and viruses, that inhabit the gastrointestinal tract. These microorganisms play a fundamental role in the physiology of the human body, contributing to the digestion of food, the absorption of nutrients and the regulation of the immune system. In addition to its presence in the digestive system, the intestinal microbiota interacts with other body systems, including the central nervous system, in a complex and multifaceted way. Gut bacteria produce a variety of bioactive substances that have the ability to influence the microbiota-gut-brain axis. These substances can positively impact neuronal circuits, promoting a healthy environment and modulating the production of neurotransmitters. However, when an imbalance occurs in the composition of the microbiota, known as dysbiosis, this interaction can become harmful. Dysbiosis can negatively affect the function of the central nervous system, altering the production of neurotransmitters and impairing the integrity and efficiency of neuronal circuits, being an aggravating factor in neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Therefore, it is crucial to understand the relationship between the gut microbiota and the nervous system to recognize how a healthy microbiota can be beneficial for neurological health and how dysbiosis can predispose to adverse neurological conditions. Understanding these mechanisms can open the way to new treatment and prevention strategies.
Quantification of oteseconazole in rat plasma using LC-MS/MS and its application to pharmacokinetic study
Authors: Susararla Krishna Phani Chandra , Shelke Om , Shorgar Neetu
Published: September 2024

Background: Oteseconazole is a new molecule launched for human treatment. However, the information is not available in the public domain for analyzing blood samples. This study describes the method development and validation using LC-MS/MS to measure the concentration of Oteseconazole in rat plasma. Methodology: The analysis method was developed using a phenyl column, which was utilized to accomplish separation. Furthermore, the mobile phase was a combination of acetonitrile and 0.1% formic acid in water, with a ratio of 30:70 (v/v). The sample was introduced into the system at a 1.0 mL/min flow rate, and the injection volume was 10 μLand analyzed for five minutes using mass spectrometer +ESI mode. Results and discussion: MRM is used to quantify Oteseconazole and Posaconazole by analyzing the transitions of their respective m/z values. The concentration ranges of Oteseconazole were 5-100 ng/mL. The correlation coefficient of Oteseconazole was found to be 0. 999. HQC, MQC, LQC, and LLQC precision and accuracy were determined to be 98.60%, 98.69%, 96.11%, and 94.48%, respectively. Respectively, the accuracy recovery of Oteseconazole was determined to be 97.48%. In pharmacokinetic studies, it was observed that Oteseconazole exhibited an average AUC0-t value of 1386 ng-hr/ml and a Cmax value of 44.864 ng/ml in rats. Conclusion: The validated approach has effectively demonstrated the determination of pharmacokinetic parameters after the oral administration of Oteseconazole in Wister rats.
Formulation and evaluation of phytosomes containing bioactive from Carica papaya seeds
Authors: Patil Rima R , Pingale Prashant L , Upasani Chandrashekhar D
Published: September 2024

Background: Papaya seeds are a rich source of proteins, fat, fibers, vitamins, minerals, monounsaturated fatty acids, polyphenols, and powerful antioxidants like flavonoids. Low solubility limits the absorption and bioavailability of herbal constituents. Hence, phytosomes of Papaya seed extract were formulated to enhance its solubility and bioavailability. Methodology: Papaya seeds were extracted using ethanol as solvent, and all the phytoconstituents present in the extract were assessed during the phytochemical screening and LC-MS analysis. In-vitro antidiabetic activity pure extract was determined by alpha-amylase and alpha-glucosidase enzyme inhibitory assay. The phytosomes of extract were formulated using the lipid thin film formation method and Soya lecithin and Cholesterol as lipids. The formulated phytosomes were analyzed for parameters such as particle size, zeta potential, encapsulation efficiency, percent drug content, and In-vitro dissolution study. The chemical nature of the formulation was studied using FTIR analysis and powder X-ray diffractometry. Thermal stability of phytosomes analyzed with the help of Differential Scanning calorimetry. Results: LC-MS identified 16 phytoconstituents. In-vitro antidiabetic activity showed 59.97% and 51.17% inhibition of enzymes alpha-amylase and alpha-glucosidase, respectively. The encapsulation efficiency of the optimized formulation was 88.41±0.91% with a particle size of 188.0±53.7nm. TEM images of formulation confirm the formation of phytosomes. FTIR, DSC, and Powder X-ray diffractometry showed no unwanted peaks. The in vitro dissolution study showed 89.26±1.05% CDR of phytosome, while the extract showed 47.78±0.59% CDR. Conclusion: Evaluation results of phytosomes suggest that this formulation can be used as an effective herbal antidiabetic formulation
Compare and Contrast of Knowledge Sharing in Virtual Teams in IT Companies and Manufacturing Industries using the Theory of Planned Behavior
Authors: Dr Antonette Asumptha J Rayan
Published: September 2024

The purpose of this research work is to Compare and Contrast of Knowledge Sharing in Virtual teams in IT companies and Manufacturing industries Using the Theory of Planned Behaviour. In this research study, we understand the Theory of Planned Behaviour (TPB) Models with Structural Equation Modeling Methodology. In this research study, we use TOOLS like IBM SPSS (Statistical Package for Social Sciences), IBM AMOS, TABLEAU.
Scope of Virtual Teams
Though virtual teams hope deeply on information and communication technology but it is not just circumscribed to the IT industry. Today almost every industry sector extending from construction, academics, manufacturing, non-profit, automotive and healthcare and to retail are promoting virtual teams. From corner to corner of the world, on one hand loftier organizations like Hewlett Packard, Whirlpool, Texas Instruments, British Petroleum etc with their gigantic possessions and proficiencies fascinated on the doles of virtual teams to strengthen their efficiency and services to customer. Fundamentally all principal occupations or job roles like Research and development, engineering, finance, sales, logistics, business development and Human resources can be consummated in a virtual atmosphere. As Covid 19 affected the globe and made a huge loss, virtual teams supported the tantrum hence letting the company employees not to fail in performing their job roles.
“翻转课堂+项目导向教学”在创新创业实践课程中的应用
Authors: 华菊翠 高苛
Published: September 2024

培养具有创新精神和创业能力的高素质、创新型人才，是建设创新型国家的需要，也是深化高等教育改革，促进高校毕业生自主创业的重要途径。基于创新创业视域下人才培养的新目标和实际教学需求，以大连交通大学工科专业创新创业实践课程为对象，分析了企业经营模拟实训课程教学存在的突出问题，提出了将翻转课堂与项目导向教学法相结合的教学模式，基于认知理论设计了教学流程，阐述了教学实施效果，完善了教学评价体系，该模式的实施充分调动学生学习自主性，提升学生创新创业能力。该教学模式可以为承担具有相同特点创新创业实验课程的教师提供一定的借鉴和参考。
Discounted monetary value of human lives lost during the mass demonstrations in Khartoum State, Sudan, 2022
Authors: Ahmed Huda , Idris Ibtisam , Osman Mazin
Published: September 2024

BACKGROUND: Sudan is rich in natural resources and diverse climate but faces significant food insecurity. The country’s challenges stem from prolonged civil wars and economic decline after South Sudan’s secession, leading to political instability and uprisings. The human cost has been devastating, with millions killed or affected by violence, displacement, and infrastructure destruction. OBJECTIVE: This paper aimed to estimate the total discounted value of 112 human lives lost during peaceful demonstrations in Khartoum State in 2022. METHODS: Data collected by the Doctors’ Committee from Oct 2021 to Oct 2023 was used. The Human Capital approach (HCA) estimated the total discounted value of human lives lost using a 3% discount rate and the national life expectancy in 2022 as 65.86. Sensitivity analysis tested the robustness of the results. The model was re-estimated using 5% and 10% discount rates and global and Sub-Saharan life expectancies. RESULTS: Human lives lost had a total discounted value of $1,871,745 and an average value of $136,816 per life. Recalculating the total discounted value of human lives lost (TDVHL) using higher rates, 5% and 10%, reduced the values by $499,516 (26.7%) and $1,094,609 (58.5%), respectively. Using Sub-Saharan life expectancy reduced the TDVHL by $105,821 (5.7%), while the global life expectancy increased it by $130,992 (7.0%). About 82% of the TDVHL was shared by dead persons aged 15-29. The average value per dead person decreased with age. The average for the 14-19 age group was almost four times that of the 55-59 group. CONCLUSION: The study reveals the high economic cost of premature deaths from mass demonstrations in Khartoum State, stressing the need for policies protecting young people and promoting stability to drive economic growth and sustainable development KEYWORDS: Human Capital Approach, Life expectancy, Dead persons, Mass demonstrations, Sensitivity analysis, Total discounted value of human lives lost
The Analysis Study of Histopathologic Diagnosis of Metastatic Basal Cell Carcinoma of Skin: A Comprehensive Systematic Review
Authors: Prastyo Wahyu Agus , Nugraheni Artha Investari , Ayuningrum Mutia Ruliana
Published: September 2024

Background: Metastatic basal cell carcinoma (MBCC) occurs at an exceedingly low rate, with an estimated incidence of 0.0028%, or 28 cases per 1,000,000 BCC diagnoses. The biological mechanisms underlying the metastatic potential of BCC remain poorly understood. This systematic review aims to evaluate the histopathologic features of MBCC based on literatures of the last 10 years. Methods: The study adhered to PRISMA 2020 standards, examining English literature from 2014 to 2024. It excluded editorials, reviews from the same journal, and submissions without a DOI. PubMed, SagePub, SpringerLink, and Google Scholar were utilized as literature sources. Result: Initially retrieving 360 articles from online databases (PubMed, SagePub, SpringerLink and Google Scholar) eight relevant papers were selected after three rounds of screening for full-text analysis. Conclusion: Histopathologic diagnosis of metastatic basal cell carcinoma is crucial for determining tumor type, assessment of invasion depth, examination of excised margins, and identification of lymphovascular or perineural invasion. Molecular analysis can reveal mutations influencing tumor behavior and treatment resistance.
How to Have a Good Day at Work: Leveraging Positive Psychology and Self-Management to Thrive
Authors: Westover Jonathan
Published: September 2024

This article discusses research-backed strategies from positive psychology that individuals can utilize to increase the likelihood of having more positive and productive workdays. It outlines how adopting an optimistic explanatory style when facing challenges, properly managing energy levels in addition to time, cultivating quality relationships with colleagues, and prioritizing self-care activities are evidence-based techniques that can positively shape one's daily work experiences. Specific examples are provided for how transportation managers, financial analysts, and software engineers can apply these approaches in their roles and industries. The article concludes that while external factors influence workdays, professionals hold significant agency to intentionally apply self-management techniques grounded in research to better navigate demands, enhance well-being, boost job performance, and optimize their daily experiences at work. Proactively utilizing positive psychology strategies emp
Carbohydrate Mouth Rinse Improves 1.5 h Run Performance: Is There a Dose-Effect?
Authors: Wright Benjamin F. , Davison Glen
Published: September 2024

There is a substantial body of recent evidence showing ergogenic effects of carbohydrate (CHO) mouth rinsing on endurance performance. However, there is a lack of research on the dose-effect and the aim of this study was to investigate the effect of two different concentrations (6% and 12% weight/volume, w/v) on 90 minute treadmill running performance. Seven active males took part in one familiarization trial and three experimental trials (90-minute self-paced performance trials). Solutions (placebo, 6% or 12% CHO-electrolyte solution, CHO-E) were rinsed in the mouth at the beginning, and at 15, 30 and 45 minutes during the run. The total distance covered was greater during the CHO-E trials (6%, 14.6 ± 1.7 km; 12%, 14.9 ± 1.6 km) compared to the placebo trial (13.9 ± 1.7 km, P < 0.05). There was no significant difference between the 6% and 12% trials (P > 0.05). There were no between trial differences (P > 0.05) in ratings of perceived exertion (RPE) and feeling or arousal ratings suggesting that the same subjective ratings were associated with higher speeds in the CHO-E trials. Enhanced performance in the CHO-E trials was due to higher speeds in the last 30 minutes even though rinses were not provided during the final 45 minutes, suggesting the effects persist for at least 20-45 minutes after rinsing. In conclusion, mouth rinsing with a CHO-E solution enhanced endurance running performance but there does not appear to be a dose-response effect with the higher concentration (12%) compared to a standard 6% solution.
Penyelesaian Wanprestasi pada Perjanjian Sewa Beli Sepeda Motor Bekas di UD.MBS-Motor
Authors: Sinaga Sangap Mangatur , Heriyanti Yuli , Sutrisno Hafiz
Published: September 2024

The need for transportation is very important both for transportation of school children and even for business purposes. One of the transportation needs is a motorbike. For some people the need to own a motorbike can be fulfilled easily but for some it is still difficult because of economic limitations. As a result of the community's purchasing ability in cash is reduced, then there is a sale and purchase in installments with a lease and purchase agreement, which can cause default problems. settlement of the price of the goods that have been mutually agreed upon and which is bound in an agreement and the ownership rights to the goods are only transferred from the seller to the buyer after the total price has been paid in full by the buyer to the seller. at UD. MBS-Motor, namely: What are the factors that cause default in the motor vehicle rental agreement and what is the form of settlement of the default in the used motorcycle rental agreement at UD. MBS-Motor. This research was conducted using the observation method by collecting data by direct question-and-answer interviews with debtors who defaulted and samples were taken randomly as much as 10% of the sample population, and data collection was also carried out by interviewing parties. company. From the direct research results obtained several factors that cause default, namely socio-economic factors and the existence of bad faith from the debtor. Problem solving in the motor vehicle rental agreement at UD. MBS-Motor usually uses two methods, namely by deliberation to reach consensus, and by court lawsuits, but in practice it often uses the deliberation and consensus method, because it is considered more effective and less complicated, unless the tenant really does not want to be responsible for the mistakes that have been made he did.
Sistem Informasi Geografis Pemetaan Penyebaran Penyakit Demam Berdarah Di Kabupaten Kampar Berbasis Web (Programming)
Authors: Oktaviarli Zendy , Azriadi Emon , Gusman Deddy
Published: September 2024

Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus infection. DHF is an acute disease with clinical manifestations of bleeding that causes shock that ends in death. Dengue fever is caused by one of the four virus serotypes of the genus Flavivirus, family Flaviviridae. Almost every year an Extraordinary Event (KLB) occurs in several areas during the rainy season. This disease is still a public health problem and is endemic in several districts/cities in Indonesia. Dengue Hemorrhagic Fever (DHF) is still a public health problem in Kampar Regency which requires serious attention from various parties considering that this disease has the potential to cause an outbreak and is a threat to the wider community. Therefore it is necessary to have a web-based Geographic Information System for Mapping the Spread of DHF in Kampar District so that it can assist the Health Service and the community in handling DHF in Kampar District. The designed system is a web-based system as a medium for providing information to the public. In testing the system using the black box testing method.
Analisa Pengaruh Penampang Penghantar Terhadap Rugi Rugi Daya Korona Pada Sutet 275 kV
Authors: Saraswati Eka Marta
Published: September 2024

This calculation aims to obtain the value of power losses caused by the condition of the conductor wire. The research results show that the corona power loss value is affected by the vd value due to good or bad weather, so if the weather is good then the corona power loss value will be low, whereas if the vd value is bad weather then the corona power loss value increases. Where the m0 value used of 0.83 can produce a critical voltage value of 144.77 kV/cm, the m0 value used of 0.84 can produce a critical voltage value of 146.52 kV/cm, the m0 value used of 0.85 can produce a voltage value the critical voltage is 148.27 kV/cm, the m0 value used is 0.86, the critical voltage value is 150.02 kV/cm, the m0 value used is 0.87, the critical voltage value is 151.77. So it can be concluded from the calculation above that if If the m0 value is increased, the resulting vd value will increase, and if the m0 value is decreased, the vd value will decrease.
RISK FACTORS RELATED TO CONTACT DERMATITIS IN WORKERS DUE TO PESTICIDE EXPOSURE IN PALM OIL PLANTATIONS
Authors: Maksuk Maksuk , Ardiansyah Ardiansyah , Kumalasari Intan
Published: September 2024

Pesticides are the most widely used chemicals to control pests and diseases in Indonesia, especially in plantations, including oil palm plantations. Exposure to pesticides can cause health problems and death. One of the most common health problems caused by exposure to pesticides is contact dermatitis. This research was an analytic observational with a cross-sectional design. This research was conducted in oil palm plantations in Banyuasin Regency in April - October 2016, with a sample of 60 respondents; the samples were taken randomly. The results of the analysis found contact dermatitis (62%), incomplete use of personal protective equipment (58.3%), eating/drinking/smoking during application (61.7%), and not decontaminating after exposure to pesticides (76.7%). Statistical test results showed that length of work, respiratory exposure, use of personal protective equipment, and decontamination after spraying were associated with contact dermatitis (p v < 0.05). Workers cause contact dermatitis after spraying, not cleaning the body, and not using personal protection completely and according to standards. Therefore, companies must provide a special room for cleaning the body, and personal protective equipment must be available completely and according to standards.
Tinjauan Hukum Islam tentang Sistem Bagi Hasil dalam Usaha Bersama
Authors: Umar M Abdullah
Published: September 2024

Para ahli hukum Islam secara sepakat mengakui keabsahan mudharabah ditinjau dari segi kebutuhan dari manfaat pada suatu segi dank arena sesuatu dengan ajaran dan tujuan syari’ah dan segi lainnya. Cara penghitungan keuntungan dalam bagi hasil mudharabah yaitu dalam pembagian keuntungan harus dinyatakan dalam bentuk persentase antara kedua belah pihak. Bagi untung dan rugi bila laba besar, maka kedua belah pihak mendapatkan keuntungan yang besar dan sebaliknya. Menentukan besarnya keuntungan ditentukan berdasarkan kesepakatan masing-masing pihak yang berkontrak. Tujuan dalam penelitian ini adalah untuk menganalisis  tinjauan hukum Islam tentang sistem bagi hasil usaha bersama. Penelitian ini merupakan library research. Pengumpulan data dilakukan dengan menggunakan data sekunder yang berasal dari buku-buku, literatur, jurnal, karya tulis, dan internet. Hasil penelitian mengemukakan berdasarkan Fatwa Dewan Syariah Nasional Majelis Ulama Indonesia No:l05/DSN-MUI/X/2016 Tentang Penjaminan Pengembalian Modal Pembiayaan Mudharabah, Musyarakah, dan Wakalah Bil Istitsmar. Menurut Fatwa Dewan Syariah Nasional Majelis Ulama Indonesia menjelaskan bahwa keuntungan harus disertai oleh kesediaan menanggung resiko. Dalam bekerja sama seharusnya pelaku bisnis menegakkan sistem keadilan pada pembagian keuntungan maupun kerugian, sebagaimana yang dijelaskan dalam Al Qur’an Surah An Nahl ayat 90. Dalam melakukan perjanjian kerja sama harus menerapkan sikap transparan terhadap hal-hal yang berkepentingan terhadap usaha yang dijalankan. Dan dalam pengambilan keputusan, harus atas dasar persetujuan dan keridhaan kedua belah pihak.
KIAN MENDUNIA TREN WISATA HALAL: RELIGIUSITAS DAN EFIKASI DIRI BERWISATA
Authors: Anwar L Nata Andrian
Published: September 2024

Developing halal tourism is considered to be very good tourism progress in terms of economic, social and cultural conditions for a region in Indonesia and even the world which indirectly feels the impact both economically and socially. This research is a library research. Data collection was carried out using secondary data derived from books, literature, journals, written works, and the internet. Religiosity and travel self-efficacy have a role in the interest in halal travel which can be seen from the generation of Muslim tourists, namely a high level of religiosity will have a desire to choose to visit halal tourist destinations and a high tendency for Muslim tourists to experience new experiences and adventures in tourist attractions. lawful. The trend of halal tourism is increasingly global, this can be seen from the many travel agents who are tempted to enter the halal tourism market where the potential for halal tourists is truly amazing.
 
Keywords: Religiusity, Tourist Self-Efficiency, Halal Tourism.
Pengaruh Kontribusi Dana Peserta terhadap Nilai Surplus Underwriting Pada Pt. Asuransi Jiwa Syari’ah Al Amin Bandar Lampung
Authors: Dwi Cahyani Miranti
Published: September 2024

Participant contribution (premium) is a form of mutual cooperation in which each participant contributes funds to PT. Al Amin Syari'ah Life Insurance and these participants are entitled to compensation for their contribution based on the amount of shares (premium) owned (paid). In the context of Sharia, financial investment can be understood as engaging in trade or business endeavors. These business activities encompass various forms, including enterprises focused on products, assets, or services. This research is a study conducted using a combined approach of quantitative and qualitative methods. The application of the analytical method in this study is to use a combination of quantitative and qualitative. Based on the correlation coefficient test, the results stated that the participant fund contribution variable (X) had a moderate effect on the underwriting surplus value variable (Y). From the hypothesis test with consideration of the decision to compare the tcount value with the ttable value, the results state that H0 is accepted and H1 is rejected. Based on the determination test, the results stated that the variable contribution of participants' funds (X) only affected the underwriting surplus value variable (Y) of 23.6%. It can be concluded from the study's findings that the hypothesis proposed has been invalidated, as no significant impact was observed between the contribution of participant funds and the underwriting surplus value at PT. Al Amin Sharia Life Insurance in Bandar Lampung.
Pemberdayaan Ekonomi Masyarakat Di Kelompok Madu Langkapura: Implementasi Bank Sampah
Authors: Margaretta Indarti Sahaji , Riani Novi , Rahmahwaty
Published: September 2024

Waste is a troubling problem in many countries, including Indonesia, with its impact that extends to various aspects of life. The amount of waste continues to increase along with changes in people's consumption behavior. In this context, the implementation of waste banks emerges as a solution for managing waste and empowering the community's economy. Community economic empowerment is an effort to strengthen and improve their economic potential. A waste bank is a waste management system that facilitates the collection, sorting, and sale of waste with the aim of reducing waste and providing economic benefits to the community. The research used a field research approach with qualitative methods. Data were obtained through interviews, observations, and related documents. Data analysis is descriptive and interpretative. The implementation of the Waste Bank in the Langkapura Honey Group increases community awareness about waste management, empowers the economy, and improves financial literacy. The Waste Bank is not only a place for collecting waste but also an education and empowerment center. The implementation of the Waste Bank in the Langkapura Honey Group succeeded in changing the community's view of waste into an economic source and providing financial benefits. Active education about waste and financial literacy are the keys to success. Suggestions include increased socialization, operational efficiency, collaboration, periodic evaluation, and further research.
Analisis Penerapan Akuntansi Syariah Berdasarkan Pernyataan Standar Akuntansi Keuangan (PSAK) 102 Tentang Pembiayaan Murabahah Pada Pt. Bank Pembiayaan Rakyat Syariah Metro Madani (BPRS Metro Madani)
Authors: Lizza Irma , Reza Mohammad Faizal , Mahfudz Agus
Published: September 2024

In raising funds, Islamic banks accept deposits from the public. At the same time, Islamic banks provide services in the form of financing and investment as well as distributing money. Financing at Islamic banks is one of the pillars of banking. Sharia banks offer several types of financing, including murabahah financing. This study delves into the murabahah financing practices at PT. Metro Madani BPRS, conducted through a qualitative approach examining written and spoken evidence. Murabahah, a key Islamic finance tool, involves the bank purchasing goods upon customer orders and reselling them with a pre-determined profit margin. Unlike conventional banks, PT. Metro Madani avoids speculative inventory purchase. Murabahah goods are valued at their initial sales price and recognized in the financial statements. The murabahah profit margin is initially equal to the purchase price plus the agreed profit. However, at the end of each reporting period, the profit margin is revalued to its net present value, ensuring accurate financial representation. Murabahah receivables are reported at their realized value after adjusting for potential losses, while deferred margins and payments are presented as deductions from their respective receivable and liability accounts. Notably, murabahah liabilities also reflect their realized value, further emphasizing transparency and risk management. This practice adheres to Financial Accounting Standards (PSAK) 102, ensuring accurate and reliable financial reporting of murabahah financing at PT. Metro Madani BPRS.