bluuebunny/crossref_metadata_2025 huggingface dataset:
Metagenomics analysis of viruse populations from feces of diarrheal geese in Sichuan Province
Authors: Chen Guo , Ma Rongzhi , Zhang Huanrong
Published: October 2024

In recent years, novel viruses have brought serious economic losses to the goose industry. In this study, we performed viral metagenomics analysis on fecal samples from sick geese with clinical symptoms of diarrhea in a goose farm in Sichuan, China. The results showed that six viruses belonging to four virus families were identified in the fecal samples, including goose calicivirus, a member of the proposed genus sanovirus in the family Caliciviridae; two novel species in Picornaviridae, goose megrivirus and goose picornavirus; goose astrovirus type 1, a lesser-reported member of goose astrovirus; and partial segments of Rotavirus F and Rotavirus G. All of these viruses are associated with avian diarrhea and may be the pathogens causing diarrhea in geese on this farm. This research enhances the diversity of viruses that infect geese and serves as a valuable reference for the prevention and control of goose diseases.
FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin Destruction Complex and Enhance Wnt Signaling Pathway Activation
Authors: Jiang Tao , Chen Hao , Lin Fangyu , Liu Jialin , Lin Xiaoyan , Gao Wenyu
Published: October 2024

Background: Elevated FNDC1 expression in gastric cancer (GC) cells activates the Wnt/β-catenin pathway, contributing to their malignant traits. However, the exact mechanism governing this process remains unclear.
Methods: Bioinformatics analyses were used to identify the expression of FDNC1 in pan-cancer, its correlation with clinical outcomes, and biological functions in GC. Co-immunoprecipitation assays and western blot elucidate the interaction between FDNC1 and Gβ2/Gγ2 and the expression of Axin1, GSK3β, APC, and Dvl. The specific binding sites of FNDC1 and Gβ2 were explored by co-immunoprecipitation.
Results: FNDC1 was highly expressed in GC tissue, and its expression level is positively correlated with poor prognosis of GC. Functional enrichment analysis shows that FNDC1-related genes may participate in regulating the Wnt signaling pathway. In vitro assays prove that FNDC1 competitively binds to the Gβ2 protein. This binding caused Dvl to separate from Gβγ. Subsequently, Dvl was released and recruited Axin1, facilitating the degradation of Axin1 and activating the Wnt/β-catenin signaling pathway. We further identified the WD5 amino acid segment (residues 224-254) as the specific binding region of FNDC1 on Gβ2.
Discussion: This study reveals a novel mechanism where FNDC1 competitively binds Gβ2, inhibiting β-catenin degradation and enhancing the Wnt/β-catenin signaling pathway.
Comparative Study of Linear & Non-linear Gravity Models in Bianchi Type-III Space-Time
Authors: MISHRA RAVI KANT , Sharma Rahul
Published: October 2024

In this study, we explore the dynamics of Bianchi type-III space-time within the framework of gravity, focusing on both linear and non-linear forms of function. We analyze the behavior of cosmological parameters by assuming the deceleration parameter (DP) as a simple linear function of the Hubble parameter. Key cosmological parameters such as the scale factor, Hubble parameter, DP, spatial volume, shear scalar, expansion scalar, energy density, pressure, and the equation of state (EoS) parameter are expressed in terms of the redshift parameter. Their dynamic behaviors are graphically presented for both linear and non-linear forms of gravity. Our results align with recent cosmological observations, with the non-linear form of exhibiting a stronger tendency toward accelerated cosmic expansion compared to the linear model. The EoS parameter indicates a quintessence phase, driving the universe's accelerated expansion, as recently investigated by Varshney et al. (2023). Additionally, we examine the violation of the strong energy conditions, a crucial aspect in modified gravity theories. The model parameter and the current value of the Hubble parameter are estimated using the Hubble data set and Pantheon+ SHOES data set, further validating our theoretical model.
Evaluation of Knowledge, Attitude, and Practice of Dental Professionals Towards Green Dentistry in Karachi City- a Cross-Sectional Survey
Authors: Billoo Muhammad Sadiq , Khan Shahrukh Ali , Kazmi Syed Murtaza Raza , Jabeen Syeda Farah , Khalid Taimur
Published: October 2024

Introduction: Environmental degradation from pollution, global warming, and industrialization, is alarming with dentistry significantly contributing through mercury and plastic toxicity from improper waste handling
Aim: To evaluate the knowledge, attitude, and practice of Dental professionals towards “Green Dentistry” working in the public and private sectors of Karachi city.
Design: A cross-sectional survey
Setting: Karachi, Pakistan (Online)
Materials and Methods: An online questionnaire was conducted among dentists of Karachi, Pakistan, from January to June 2023 collecting participant’s demographic data and assessing knowledge, attitude, and practice of eco-friendly dentistry.
Results: With a 36% response rate, most respondents (48.54%) were General Dental Practitioners (GDPs) (58.48%). Dental consultants (DC) exhibited higher awareness of green dentistry (29%) with 50% of DCs favoring digital radiography as environment friendly (p=<0.05). Green dentistry practices were more prevalent among DCs with 42.8% (p=<0.05) eliminating amalgam usage, while more GDPs (72.2%, p=<0.05) adopted re-usable lab coats and patient drapes.
Discussion and Conclusion: Awareness of “Green Dentistry” is generally lacking among participants. Both GDPs and DCs are inclined towards adopting environment-friendly dental practices. Education on energy conservation and materials is essential to reduce waste in the dental industry.
WITHDRAWN: Design and Simulation of a Microstrip 16x16 Butler Matrix for NR-IFF Radar Application
Authors: Fallah Mohsen , Nekounam Majid , Armaki Seyyed Hossein Mohseni
Published: October 2024

In this paper, a new microstrip design for the 16x16 Butler matrix is presented. It is well-known that as the number of input/output ports of the Butler matrix increases, so does the number of internal crossovers and thus the complexity of the whole structure increases impractically. Therefore, most reports have been limited to the design and realization of 4x4 and 8x8 Butler matrices. However, in this paper and through the relocation of input/output ports and also by using a two-layer substrate, a new 16x16 Butler matrix is designed to be used in a Non-Rotating IFF radar for the commutation of the active sector of its cylindrical antenna array.
Population Pharmacokinetics of Brexpiprazole in Japanese Healthy Subjects and Patients with Schizophrenia
Authors: Higashi Koushi , Sasaki Tomohiro , Aoki Kazuo , Sekine Daisuke , Maeda Kenji , Shiomi Yuki , Kawai Yosuke
Published: October 2024

Brexpiprazole, widely approved for the treatment of schizophrenia, is an atypical antipsychotic that modulates serotonin–dopamine activity. To better understand the pharmacokinetics (PK) of brexpiprazole in Japanese patients, a population PK model was constructed and used to estimate steady state PK profiles and parameters as well as dopamine D2/D3 receptor occupancy profiles after repeated oral administrations of brexpiprazole at 1 and 2 mg/day. Nonlinear mixed effects modelling was used to analyse data from a total of 398 healthy subjects and patients with schizophrenia who received brexpiprazole in three Japanese clinical trials. The PK of brexpiprazole were well described by a two-compartment disposition model with transit absorption compartments. Estimated glomerular filtration rate, age and cytochrome P450 2D6 phenotype were identified as significant covariates on CL/F only. The model predicted that, at a dose of 2 mg/day, trough plasma concentration (90% prediction interval) of brexpiprazole is 77.1 (22.4–173) ng/mL and that dopamine D2/D3 receptor occupancy is > 80% over one day for most patients at steady state. This suggests the recommended maintenance dose of 2 mg/day of brexpiprazole leads to clinically useful dopamine D2/D3 receptor occupancy at steady state in Japanese patients.
Multi-stage Crop Planting Strategy Optimization Model Based on PSO Algorithm
Authors: Wang Jiaying , Wang Yiquan
Published: October 2024

This paper presents a multi-stage crop planting strategy optimization model utilizing the Particle Swarm Optimization (PSO) algorithm. The model aims to address key challenges in agriculture, such as fluctuating market demands, climate variability, and rising production costs. Over a seven-year planning horizon (2024–2030), the model dynamically adjusts crop planting strategies by integrating factors like crop yield, market prices, and crop rotation. The proposed framework optimizes both crop selection and area allocation to maximize economic profitability while maintaining sustainable practices. Unlike traditional static models, this approach accounts for uncertainties and adapts to real-time changes in market conditions. The model's ability to adjust planting strategies based on PSO ensures that farmers can optimize yields and reduce waste through flexible decision-making. Experimental results demonstrate the model's effectiveness in dynamically optimizing planting strategies while satisfying constraints such as land availability and crop rotation.
AI-Driven Decision Support Systems for Healthcare Diagnosis
Authors: Egon Axel , broklyn Peter , Gracias Abram
Published: October 2024

Artificial Intelligence (AI) has transformed various industries, with healthcare being one of the primary beneficiaries. AI-Driven Decision Support Systems (AI-DSS) have shown tremendous potential in augmenting healthcare diagnosis, enhancing both accuracy and efficiency. These systems leverage advanced machine learning algorithms, natural language processing, and data analytics to assist healthcare professionals in diagnosing diseases, predicting patient outcomes, and personalizing treatment plans.
AI-DSS in healthcare can analyze large volumes of patient data, including medical history, lab results, and imaging, far beyond the capabilities of human practitioners. By identifying patterns and correlations that might not be immediately apparent, these systems provide diagnostic insights that can improve decision-making. Moreover, AI models, trained on vast datasets, can support early detection of diseases such as cancer, cardiovascular conditions, and neurological disorders, potentially improving patient outcomes by enabling timely interventions.
Despite the benefits, integrating AI-DSS into healthcare also presents challenges. These include ensuring data privacy and security, addressing algorithmic biases, and fostering trust among healthcare providers and patients. Additionally, the role of human oversight remains crucial, as AI should complement rather than replace clinical judgment.
In conclusion, AI-driven decision support systems represent a significant advancement in healthcare diagnosis, offering tools to improve diagnostic precision and patient care. However, careful implementation, ethical considerations, and continued human involvement are essential to maximize their potential and ensure they enhance rather than disrupt the healthcare landscape.
National Borders among Families: Removal and ‘Bare Life’ in India
Authors: Punathil Salah
Published: October 2024

This paper is about the state-driven process of ‘migrant ‘illegality’ (Genova 2002) and its impact on the life of Bengali speaking residents in the Assam state of India. While the movement of people across borders between India and present-day Bangladesh has been historical and complex, this ethnographic work explores how the state-driven process of migrant illegality and the production of ‘bare life’ have disrupted intimate relations and family life among the migrant population in Assam. While the recent NRC (National Register of Citizens) update in Assam identified 1.9 million people as illegal migrants, there has been bureaucratic enactment of ‘migrant illegality’ by Assam Border Police for the last several years. The institutional procedures, court documents and narratives of the select cases of ‘detected’ as well as ‘detained’ residents from ethnographic fieldwork reveal how the absence of formal papers and errors in the family records, kinship relations and property inheritance among the poor migrant families transforms actual citizens to ‘illegal migrants’ in the bureaucratic manoeuvring and reduces them to their ‘bare life’. The paper also shows how prejudice, arbitrariness, and contradictions feed into the bureaucratic process and lead to intense crises among family units, as several migrant families have both Indians and alleged ‘Bangladeshis’ in their homes today. The paper argues that the major consequence of this state-driven ‘migrant illegality’ in the last two decades has been the creation of national borders among families, unsettling intimate relations and shared spaces.
The effectiveness of a mobile mammography units in breast cancer screening
Authors: Kaprin D. A. , Perkhov V. I. , Denisova M. N.
Published: October 2024

Breast cancer remains the leading cause of death in the female population. Screening studies are conducted in order to detect the disease at an early stage. At the same time, domestic authors emphasize the lack of alternatives to preventive mammography in breast cancer screening and the prospects of using mobile mammographs for early diagnosis of breast cancer and precancerous breast diseases.

Aim. To evaluat the results of the use of mobile mammography units for active and early detection of breast cancer.

Materials and methods. The research uses methods of content analysis, information and analytical materials of Russian and foreign researchers, and forms of federal statistical observation. Statistical research methods were used to analyze the data obtained.

Results. Regression analysis with a very low probability of error (p = 0.001) showed that the larger the total volume of mammographic studies with preventive purposes in the subjects of the Russian Federation, the higher the proportion of cases of active detection of breast cancer, although this relationship is rather weak. Taking into account the obtained value of R2 (0.192), only 19.2% of the increase in the proportion of breast cancer cases detected actively can be explained by an increase in the volume of preventive mammograms. The correlation analysis showed that the volumes of preventive mammograms performed using mobile devices in the subjects of the Russian Federation were not associated with either the proportion of breast cancer cases detected actively or with the proportion of breast cancer cases detected in the early stages. At the same time, it is worth noting that the obtained value of p ≥ 0.5 indicates a statistically insignificant result of evaluating the relationship between variables, the interpretation of which should be performed with caution.

Conclusion. Despite the high cost of mobile mammography units, the increase in their number in the subjects of the Russian Federation and the growth in their activities, the contribution of these diagnostic devices to solving the problem of early and active diagnosis of breast cancer remains uncertain. More promising are personalized approaches to the timely detection of cancers, including breast cancer, based on an assessment of the individual risk of their occurrence.
The Mediating Effect of Organizational Commitment and Occupational Self-Efficacy on Work Engagement
Authors: Sandroto Christine Winstinindah , Alamsyah Athalia Anabel
Published: October 2024

The goal of this study is to determine the effect of occupational self-efficacy on work engagement in millennial-generation employees, with organizational commitment as a mediation variable. The population of this research includes members of the millennial generation working in Jabodetabek. The sample comprises 250 respondents; the sampling technique is non-random sampling using the convenience sampling technique. Data processing uses Macro Preacher & Hayes contained in SPSS verse 25, called PROCESS. The study results reveal that occupational self-efficacy has a significant effect on organizational commitment, and organizational commitment has a significant effect on work engagement. Occupational self-efficacy has a significant effect on work engagement, and organizational commitment mediates occupational self-efficacy and work engagement among millennial generation employees who work in Jabodetabek. The direct effect of occupational self-efficacy on work engagement is greater than the indirect effect.
Does Green-Label Influence Green Purchase Intention, Attitude, Subjective Norms, Behavioral Control, and Willingness To Pay as Moderation?
Authors: Lukmawan Wisnu Ridho , Wulandari Ririn
Published: October 2024

The purpose of this study was to test and analyze influenced eco-labels, attitudes, subjective norms, and behavioral control on green purchase intention, as well as willingness to pay as a mediator to strengthen the influence green purchase intention (GPI) on green purchase behavior (GPB). The population of this study were Millennials and Gen Z who had purchased green products in Jabodetabek. The number of samples was 181 samples, determined based on Hair's Theory which allows for an unknown population. The sampling technique used nonprobability sampling and purposive sampling. Data analysis used the Least Square Partial Structural Equation Model (PLS-SEM). The results showed that eco-labels did not influence green purchase intention, but influenced green attitude and behavioral control. Conversely, ecolabels did not influence subjective norms. Furthermore, willingness to pay was unable to moderate the influence of green purchase intention on green purchase behavior.
Commentary on the Obtention of Semi-Synthetic Derivatives from Natural Products for Medicinal Applications: Advances, Challenges, and Perspectives
Authors: Florencia Musso , Brunella Biscussi
Published: October 2024

Plants have historically been a primary source of medicines due to their diverse
molecular and structural composition. Plant metabolism, comprising primary and secondary
processes, produces primary metabolites crucial for growth and secondary metabolites,
or natural products (NPs), with specific biological functions. These small molecules
are instrumental in pharmacology for their ability to penetrate biological barriers and interact
with intracellular targets. The structural complexity and limited availability of NPs
have led to research focusing on enhancing their diversity through semi-synthesis. In this
commentary, examples of various semisynthetic derivatives of NPs obtained through different
synthetic strategies, such as organic semi-synthesis or combinatorial chemistry, are
cited. Additionally, the importance of developing hybrid molecules based on the combination
of two or more distinct pharmacophores is emphasized. This strategy has been widely
implemented to obtain new multitarget drugs applicable to the treatment of multifactorial
neurodegenerative diseases, where stimulating the cholinergic system by modulating different
therapeutic targets is crucial. However, challenges, such as structural complexity,
raw material availability, and the need for precise synthetic methods, persist. Innovations
in synthetic routes, sustainable harvesting, and biotechnological advances are critical to
overcoming these barriers. The integration of omics technologies, green chemistry principles,
and global collaboration is essential to maximize the potential of NPs in drug development,
ensuring sustainable and efficient production of new therapeutics.
Dosimetry Comparison of 3D Conformal Radiotherapy and Intensity-modulated Radiotherapy for the Treatment of Brain Tumors: A Meta-Analysis
Authors: Barman Ashima , Roy Sagor Kumar , Mahamud Sujan , Karmaker Nupur , Islam Md. Nurul
Published: October 2024

Background:

This study aimed to evaluate IMRT and 3D-CRT in the therapy of brain
tumor (BT) in relation to dose-volume histograms (DVHs) parameters, such as Heterogeneity Index
(HI), Conformity index (CI), Equivalent Uniform Dose (EUD), and mean dose (Dmean) outcomes,
including the program for the tumors of the brain and estimate whether a favored procedure
can be found through the features of the pretreatment.

Method:

A search of the PubMed, Cochrane Library, and Embase datasets from their beginnings
from January 2006 to September 2022 was conducted. The authors separately selected and evaluated
studies for qualifying criteria and bias risk.

Result:

Seven studies in total were included. Of them, a total of 387 patients were integrated for
the Heterogeneity index (HI), Conformity Index (CI), Equivalent Uniform Dose (EUD), and mean
dose (Dmean) comparison analysis, which showed 3D-CRT & IMRT with odd ratio (OR) =1.93;
95% confidence interval (95% CI) =1.63, 2.22; and P value=0.00. For brain tumor patients, CI
was higher in IMRT than 3D-CRT with OR= 0.72; 95% CI =0.41, 1.03; p value <0.001. EUD was
higher in IMRT than 3D-CRT, resulting in an increased overall survival with OR=-0.86; 95% CI
=-1.30, 0.42; and p value<0.001. However, no statistically significant variance was perceived in
Dmean between 3D-CRT and IMRT.

Conclusion:

Our records suggested that IMRT with conventional linacs results in a meaningfully
lower regular percentage of brain tumor volumes compared to 3D-CRT. Finally, this meta-analysis
indicated that IMRT is better than 3D-CRT and decreases the average percent irradiated
amount of the brain.
Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Tumor Immune Infiltration in Bladder Cancer
Authors: Liu Gao-Lei , Luo Hao , Liang Dan-Dan , Zhong Li , Dai Nan , Lan Wei-Hua
Published: October 2024

Background:

Bladder cancer exhibits substantial heterogeneity encompassing genetic
expressions and histological features. This heterogeneity is predominantly attributed to alternative
splicing (AS) and AS-regulated splicing factors (SFs), which, in turn, influence bladder
cancer development, progression, and response to treatment.

Objective:

This study aimed to explore the immune landscape of aberrant AS in bladder cancer
and establish the prognostic signatures for survival prediction.

Methods:

Bladder cancer-related RNA-Seq, transcriptome, and corresponding clinical information
were downloaded from The Cancer Genome Atlas (TCGA). Gene set enrichment analysis
(GSEA) was used to identify significantly enriched pathways of cancer-related AS events.
The underlying interactions among differentially expressed genes (DEGs) and cancer-related
AS events were assessed by a protein-protein interaction network. Univariate and multivariate
Cox regression analyses were performed to identify crucial prognostic DEGs that co-occurred
with cancer-related AS events (DEGAS) for overall survival. The area under the curve (AUC)
of receiver operating characteristic (ROC) curves was used to assess the efficiency of the prognostic
signatures. The CIBERSORT algorithm was used to explore the abundance of immune
infiltrating cells.

Results:

A total of 3755 cancer-related AS events and 3110 DEGs in bladder cancer were identified.
Among them, 379 DEGs co-occurred with cancer-related AS events (DEGAS), of which
102 DEGAS were associated with 14 dysregulated SFs. GSEA and KEGG analysis showed that
cancer-related AS events were predominantly enriched in pathways related to immunity, tumorigenesis,
and treatment difficulties of bladder cancer. Multivariate Cox regression analysis identified
8 DEGAS (CABP1, KCNN2, TNFRSF13B, PCDH7, SNRPA1, APOLD1, CX3CL1, and
DENND5A) significantly associated with OS, and they were further integrated into the prediction
model with good AUCs at 3-year, 5-year and 7-year ROC curves (all>0.7). Immune infiltration
analysis revealed the significant enrichment of three immune cell types (B cells naïve,
dendritic cells resting, and dendritic cell activated) in high-risk bladder cancer patients.

Conclusion:

This study not only unveiled comprehensive prognostic signatures of AS events in
bladder cancer but also established a robust prognostic model based on survival-related DEGAS.
These aberrant AS events, dysregulated SFs, and the identified 8 DEGAS may have significant
clinical potential as therapeutic targets for bladder cancer.
Investigation of Apoptotic and Anticancer Effects of 2-substituted Benzothiazoles in Breast Cancer Cell Lines: EGFR Modulation and Mechanistic Insights
Authors: Uremis Muhammed Mehdi , Ceylan Mustafa , Turkoz Yusuf
Published: October 2024

Background and Objective:

Benzothiazole derivatives, a class of heterocyclic compounds, exhibited
diverse biological activities influenced by substituents in the thiazole ring. This study aimed to synthesize these
compounds with two functional groups to investigate their potential as anticancer agents, particularly against
breast cancer. While previous research demonstrated the efficacy of 2-substituted benzothiazoles against glioma
and cervical and pancreatic cancer cells, there is a gap in studies targeting breast cancer.

Methods:

The synthesized compounds were tested in vitro using MCF-7, MDA-MB-231, and MCF-10A cell
lines, with Doxorubicin as the positive control. Various assays were conducted, including Annexin V/PI, cell
cycle analysis, wound healing, and measurement of mitochondrial membrane potential. Protein expression of
EGFR and transcription levels of apoptosis-related genes (Bax and Bcl-xL) and cancer progression-related genes
(JAK, STAT3, ERK, AKT, mTOR) were analyzed. Additionally, the balance between antioxidants and oxidants
was evaluated by measuring TAS and TOS levels.

Results:

Our findings revealed that benzothiazole compounds significantly inhibited breast cancer cell growth by
reducing cell motility, disrupting mitochondrial membrane potential, and inducing cell cycle arrest in the sub-G1
phase. These compounds increased reactive oxygen species accumulation, leading to cell death. Furthermore,
they decreased EGFR protein levels, increased Bax gene transcription, and downregulated the expression of
genes such as JAK, STAT3, ERK, AKT, and mTOR.

Conclusion:

In conclusion, benzothiazole derivatives exhibited potent inhibitory effects on breast cancer in vitro
by promoting apoptosis, downregulating EGFR activity, and modulating key signaling pathways, including
JAK/STAT, ERK/MAPK, and PI3K/Akt/mTOR. These results highlighted the potential of benzothiazole derivatives
as novel therapeutic agents for breast cancer treatment.
Significant Microbial Pathogenesis Perspective of Biliary Diseases
Authors: Sharma Chandra Kant
Published: October 2024

This review explores various biliary tract diseases caused by different organisms, in-cluding cholelithiasis, hepatolithiasis, and choledocholithiasis. The biliary tract's primary func-tions include collecting, storing, concentrating, and delivering bile juice produced by the liver. Neurohormonal systems involving the vagus and splanchnic nerves, alongside cholecystokinin, regulate gallbladder movement during fasting and digestion. Under normal conditions, bile acids play a crucial role, with approximately 95% being reabsorbed by the intestinal epithelium and returned to the liver via the portal vein system. The liver, often hailed as a miracle worker, de-toxifies, purifies, and regenerates, performing essential functions in the body. Recent research indicates that the gallbladder, akin to the intestine, harbors a diverse microbiota. Additionally, the biliary mucosa features chemical, mechanical, and immunological barriers that promote im-munological tolerance. Hepatotoxicity remains a significant global health concern and a leading cause of mortality. Providing clear and accurate information on liver toxicity is critical, especially in the context of medication safety and public health. By refining these elements, this review can effectively convey the complexity and importance of biliary tract diseases and liver function in health and disease contexts.
Acute Febrile Illness in India: An Epidemiological Retrospective Study
Authors: Kumar Kaushalendra , Tripathi Amit Kumar , Sharma Vikash Kumar , Mishra Sunil Kumar , Patnaik Ranjana
Published: October 2024

Introduction:

Acute febrile illness (AFI) is a frequent occurrence in India, often com-plicated by a multitude of pathogenic and etiological factors. In this context, it is important to analyze the biochemical, hematological, and epidemiological clinical parameters of AFI patients in the North Indian population.

Methods:

This study included 1,819 patients of various ages who presented with new-onset acute febrile illness (AFI) between 2017 and 2021. Among these patients, 211, with a median age of 40 years (ranging from 2 to 85 years), were selected for further analysis. At enrollment, clinical examination involved collecting respiratory tract specimens, blood, and urine samples for bio-chemical analysis, with subsequent data analysis conducted using statistical methods.

Results and Discussion:

The following biochemical parameters were analyzed: C-reactive pro-tein (CRP), alkaline phosphatase (ALP), serum glutamate-pyruvate transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), gamma-glutamyl transpeptidase (GGT), and total protein serum. The hematological parameters included total leukocyte count (TLC), lymphocyte count, monocyte count, eosinophil count, red blood cell count (RBCs), packed cell volume (PCV), erythrocyte sedimentation rate (ESR), hematocrit value, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). Additionally, clinical parameters such as phosphorus, urea, calcium, sodium, uric acid, bilirubin, and potassium were measured. Specific values observed were: SGPT (~113 IU/L in 2018), SGOT (~81 U/L in 2019), GGT (~148 g/L in 2018), and total protein serum (~7 g/L in 2020). The hematological parameters (TLC, lympho-cyte, monocyte, RBCs, PCV, ESR, MCV, and MCH). The regression analysis was conducted to explore the temperature recorded at the time of admission, the duration of hospital stays, and biochemical as well as hematological variables of patients suffering from AFI. Karl-Pearson's correlation coefficient and variance inflation factor for each variable mentioned above.

Conclusion:

Biochemical and hematological parameters were analyzed over different years of intake in patients with Acute Febrile Illness (AFI). Further investigation is required to explore the mechanistic pathways of infection, and preventive measures will be implemented using nat-ural products and other therapeutic interventions. Our data will offer the first systematic assess-ment of the etiological factors, along with regression analysis and the Karl-Pearson correlation coefficient for each variable in AFI patients.
Selenium Nanoparticles: Cut-edge Therapeutic Entity
Authors: Kothapalli Lata , Singh Navdeep , Thomas Asha , Ghadge Yash
Published: October 2024

Selenium is a significant trace microelement responsible for detoxification and supporting
the health of human beings. Selenium is consumed as a part of dietary supplements where in it has a
very narrow margin for its physiological role and the toxic effects produced. Selenium nanoparticles
(SeNP) have proven significant as a chemoprotective agent in treatment of the neurodegenerative
conditions, diabetes, and antimicrobial, and antioxidant activity. The present review briefs the requirement
of selenium and its various methods of preparation. Further emphasizing on the application
of SeNP for the treatment of various disease conditions. A literature search on Science Direct,
Pubmed, and Google Scholar, was done and the recent articles regarding the preparation of Selenium
NP by chemical and biological techniques including microbial conversions and using plant extracts
along with physical conversions were studied. Further diversified applications were looked for where
SeNP can exhibit antioxidant properties as Se is an innate member of the antioxidant system. Summarizing
the review on SeNP has been more exciting as Se as an element is known as trace element
but phytofabricated and biogenic preparations of SeNP having low toxicity with synergistic effects.
Toxicity studies indicate the safety of SeNP as compared to selenium oxide and itsinorganic salts,
however in-depth study and species-to-species variation must be understoodto formulate the SeNP in
the appropriate dosage form. Various techniques have been studied for the preparation of SeleniumNanoparticles
and havethe potential for application in the treatment of various lifethreateningdiseases
and metabolic disorders, infectious conditions. The synergistic effect of Se and
the plants or microorganisms known for their medicinal application reduces the toxicity of the selenium
nanoparticles when compared within organic salts. Further extensive studies on the epidemiology
regarding the variation in serum level of Se and its administration as a supplement or therapeutic
purpose can be a cut-edge treatment for life-threatening conditions.
Nanomedicine Innovations for Diabetes Management: Revolutionizing Diagnosis, Treatment, and Monitoring
Authors: Prajapati Shatrudhan , Yadav Shikha
Published: October 2024

Diabetes mellitus, a widespread metabolic disease characterized by high blood sugar
levels, affects many people globally. The limitations of conventional diagnostic and therapeutic approaches
necessitate exploring innovative strategies. Nanotechnology shows remarkable potential
for revolutionizing the field of diabetes theranostics (combined diagnosis and treatment) by enabling
accurate diagnosis and precise treatment delivery. This article provides a comprehensive review
of the latest advancements in nanomaterials for diagnosing and treating diabetes. It explores
the applications of various nanomaterials, including inorganic and organic nanoparticles, nanocomposites,
and nanostructured biosensors, in biomarker detection, glucose monitoring, insulin delivery,
and addressing diabetes-related complications. The study focuses on the synthesis and functionalization
of nanomaterials for diabetes, covering both traditional and environmentally friendly
synthesis methods. This study looks into how nanomaterials can be used to carry natural antidiabetic
extracts, recombinant insulin, and other antidiabetic drugs, to make them more bioavailable,
targetable, and effective. However, the review also talks about the problems that come with using
nanosensors to diagnose diabetes. It also looks at the newest developments in nanosensors for biomarker
detection, implantable devices, and continuous glucose monitoring. Additionally, the review
examines the potential of nanomaterials in the management of diabetic sequelae, including
diabetic nephropathy, cardiovascular disorders, retinopathy, and wound healing. We underscore
the significance of nanomaterials in islet transplantation, as they provide immunological protection
and enhance the viability and efficacy of islets. This study provides useful insights into the
prospects and challenges connected with the rapidly growing field of nanotechnology in diabetic
theranostics through a comprehensive examination of the current landscape. Academics, clinicians,
and stakeholders engaged in developing innovative nanomaterial-based approaches to accurately
diagnose and effectively manage diabetes will find this resource highly helpful.
6-9 yaş çocuklara yönelik değerler eğitimiyle ilgili yazılan öykü kitaplarının fiziksel, içerik ve resimleme özelliklerinin incelenmesi
Authors: Uygun Mehmet , Büyükkalaycı Kamer
Published: October 2024

Değerler eğitimi çocukları doğru ve yanlış arasındaki farkı anlatmayı, etik değerleri kazandırmayı ve onları sorumluluk sahibi olarak yetiştirmeyi hedefleyen bir eğitimdir. Bu araştırmada 6-9 yaş çocuklar için değerler eğitimine yönelik yazılmış öykü kitaplarında kök değerlerin (Adalet, Dostluk, Dürüstlük, Öz Denetim, Sabır, Saygı, Sevgi, Sorumluluk, Vatanseverlik, Yardımseverlik) yer verilme düzeyleri ile kitapların fiziksel, içerik ve resimleme özelliklerinin nasıl olduğu incelenmiştir. Araştırmada nitel araştırma yönteminden faydalanılmıştır. Nitel araştırma yöntemlerinden “doküman analizi” yapılmıştır. Yapılan doküman ve literatür taraması yardımıyla, kitaplardaki on kök değerin yer verilme düzeyleri, fiziksel özellikleri, içerik özellikleri ve resimleme özelliklerinin analizi yapılmıştır. İncelenen kitaplarda tespit edilen on kök değerden “yardımseverlik” değeri (f=142), “sevgi” değeri (f=169), “dostluk” değeri (f=69), “sorumluluk” değeri (f=182), “saygı” değeri (f=119), “vatanseverlik” değeri (f=23), “sabır” değeri (f=53), “özdenetim” değeri (f=176), “adalet” değeri (f=24), “dürüstlük” değeri (f=105) olarak tespit edilmiştir. İncelenen kitaplarda konuya uygun kök değerlerin yer aldığı, karton kapak, birinci hamur kâğıt kullanıldığı, kitapların büyük oranında dilbilgisi kurallarına uyulduğu ve resimlerin basit, konuya uygun, metinle ilişkili olduğu belirlenmiştir.
NORMAL GELİŞİM GÖSTEREN İLKOKUL ÖĞRENCİLERİNİN ÖZEL GEREKSİNİMLİ AKRANLARINI SOSYAL KABULÜNE YÖNELİK ÖLÇEK GELİŞTİRME ÇALIŞMASI
Authors: Arslan Erdinc , Karataş Zeynep
Published: October 2024

Bu çalışmanın amacı bütünleştirme eğitimine katılan özel gereksinimli ilkokul öğrencilerinin normal gelişim gösteren akranları tarafından sosyal kabul düzeylerinin belirlenmesine yönelik geçerli ve güvenilir bir ölçek geliştirmektir. Çalışma grubu Burdur İl merkezinde bütünleştirme uygulaması yapılan 7 ilkokulun 3. ve 4. sınıflarında eğitim gören 610 normal gelişim gösteren öğrenciden oluşmaktadır. Araştırma kapsamında geliştirilen sosyal kabul öleceğinin KMO değeri .906 bulunmuştur. Yapılan açımlayıcı faktör analizi sonucunda ölçekte 20 madde ve bu maddeleri kapsayan 4 faktör bulunmuştur. Sosyal kabul ölçeğinin toplam varyans açıklama yüzdesi %46,860 olarak bulunmuştur. Sosyal kabul ölçeğinin toplam alt boyutları arasında ayırt edicilik endeksi .80 altında bulunmuş ayırt edicilik sağladığı görülmüştür. Doğrulayıcı faktör analizi sonucunda elde edilen modele ilişkin uyum indeksleri Ki-kare/sd = 1,91 GFI=,92, CFI=,95 NNFI =,94, RMSEA =.051, SRMR=.056, olarak bulunmuştur. Bu sonuçlarla sosyal kabul ölçeğinin dört faktörlü yapısı doğrulanmıştır. Sosyal kabul ölçeğinin güvenirliğini belirlemek için yapılan madde toplam korelasyonu. 288-668 olarak ve Cronbach Alpha değeri ,85 bulunmuş, güvenirliği sağladığı görüşmüştür. Araştırma sonucunda geliştirilen sosyal kabul ölçeğinin geçerli ve güvenilir olduğu bulunmuştur.
Sosyal bilgiler yedinci sınıf ders kitabındaki çoklu modsal betimleme kullanımının incelenmesi
Authors: Çopur Ahmet
Published: October 2024

Sosyal bilgiler yedinci sınıf ders kitabında yer alan modsal betimlemeleri inceleme amacında olan araştırmanın verileri nitel araştırma türlerinden doküman incelemesi ile toplanmış olup elde edilen veriler içerik analizi ile incelenmiştir. Araştırma sonucunda; yedinci sınıf sosyal bilgiler ders kitabında modsal betimleme türlerinden en fazla resim ve fotoğraf kullanıldığı, ders kitabındaki modsal betimlemelerin önemli bir kısmının betimsel özellik açısından örtük veya belirsiz olduğu, modsal betimlerin büyük bir kısmının metin içerik bağlantısının iyi düzeyde kurulduğu ve çoklu modsal betimlemelere az sayıda yer verilmesi yanında çoklu modları meydana getiren alt modlar arasında bağlantının yetersiz kurulduğu tespit edilmiştir. Bu sonuçlara dayalı olarak; grafik ve tarih şeridi gibi modsal betimlemelere ders kitaplarında daha fazla yer verilmesi, modların anlaşılır tarzda açık olarak tasarlanması, aday ders kitapları belirlenirken kullanılan modların metin içerik bağlantısının yeterli düzeyde kurulması ölçütü getirilmesi ve çoklu modlar arası bağlantının iyi düzeyde kurulmasına özen gösterilmesi şeklinde önerilerde bulunulmuştur.
Estudio basado en la calidad del servicio en la empresa de equipos médicos (RETOMED)
Authors: Rodríguez Vinent Yailen , Montoya Ibañez Amarilys , Vinent Pérez Luz
Published: October 2024

La finalidad del presente estudio investigativo radica en la calidad del servicio en la Empresa de Equipos Médicos (RETOMED) en Santiago de Cuba en el 2022 evaluándose la satisfacción de sus consumidores. Su importancia radica en el valor de la información logrando identificar áreas de perfeccionamiento y tomas de decisiones estratégicas para mejorar la satisfacción, fomentando la retención de los compradores de las Unidades Empresariales de Base (UEB) en esta entidad. Se concibe a la investigación desde un enfoque cuantitativo porque ofrece medir el nivel de satisfacción en las empresas que solicitaron los servicios a RETOMED empleándose técnicas con el fin de enriquecer la investigación y profundizar en el estudio del cliente, la flexibilidad en el diseño de la oferta y mejores análisis de expectativas y satisfacción (estudio de mercado); de ahí su significación como perspectiva metodológica específica y complementaria, pero igualmente empírica. Este es el resultado de un estudio realizado por el Centro de Información y Gestión Tecnológica (MEGACEN) en Santiago de Cuba en el 2023 donde se determina el nivel de satisfacción basada en la calidad, a través, de la eficiencia del personal y del servicio de la Empresa de Equipos Médicos (RETOMED). Se mostró como resultados que la población de interés se encuentra en gran medida satisfecha con los procesos de calidad donde las dimensiones analizadas superaron el 75% del nivel de satisfacción observándose que existe una relación positiva entre la calidad del servicio, la eficacia y exigencia del personal.
The Effect of Nutritional Mobile Apps on Populations With Cancer: Systematic Review
Authors: Ng Krystal Lu Shin , Munisamy Murallitharan , Lim Joanne Bee Yin , Alshagga Mustafa
Published: October 2024

Background

Limited access to nutrition support among populations with cancer is a major barrier to sustainable and quality cancer care. Increasing use of mobile health in health care has raised concerns about its validity and health impacts.

Objective

This systematic review aimed to determine the effectiveness of commercial or cancer-specific nutritional mobile apps among people living with cancer.

Methods

A systematic search of the CENTRAL, Embase, PubMed (MEDLINE), and Scopus databases was carried out in May 2024. All types of intervention studies were included, except observational studies, gray literature, and reference lists of key systematic reviews. Studies were eligible for inclusion if they involved (1) patients with or survivors of cancer and (2) nutrition-related mobile apps. Studies were excluded if the nutrition intervention was not delivered via mobile app or the app intervention was accompanied by dietary counseling. The review process was conducted based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The Risk of Bias 2 and Risk of Bias in Nonrandomized Studies tools were used to assess the study quality. The Cochrane Review Manager (version 5.4) software was used to synthesize the results of the bias assessment.

Results

A total of 13 interventions were included, comprising 783 adults or teenagers with cancer. Most studies focused on breast cancer (6/13, 46%), overweight (6/13, 46%), and survivors (9/13, 69%). Data on anthropometry and body composition (7/13, 54%; 387 participants), nutritional status (3/13, 23%; 249 participants), dietary intake (7/13, 54%; 352 participants), and quality of life (6/13, 46%; 384 participants) were gathered. Experimental groups were more likely to report significant improvements in body weight or composition, dietary compliance, nutritional status, and quality of life than control groups.

Conclusions

Although mobile app platforms are used to deliver nutrition interventions, the evidence for long-term efficacy, particularly in populations with cancer, remains elusive. More robust randomized controlled trials with larger sample sizes, as well as more homogeneous population characteristics and outcome measures, are warranted.

Trial Registration

PROSPERO CRD42023330575; https://tinyurl.com/55v56yaj
Sensors for Smoking Detection in Epidemiological Research: Scoping Review
Authors: Favara Giuliana , Barchitta Martina , Maugeri Andrea , Magnano San Lio Roberta , Agodi Antonella
Published: October 2024

Background

The use of wearable sensors is being explored as a challenging way to accurately identify smoking behaviors by measuring physiological and environmental factors in real-life settings. Although they hold potential benefits for aiding smoking cessation, no single wearable device currently achieves high accuracy in detecting smoking events. Furthermore, it is crucial to emphasize that this area of study is dynamic and requires ongoing updates.

Objective

This scoping review aims to map the scientific literature for identifying the main sensors developed or used for tobacco smoke detection, with a specific focus on wearable sensors, as well as describe their key features and categorize them by type.

Methods

According to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) protocol, an electronic search was conducted on the PubMed, MEDLINE, and Web of Science databases, using the following keywords: (“biosensors” OR “biosensor” OR “sensors” OR “sensor” OR “wearable”) AND (“smoking” OR “smoke”).

Results

Among a total of 37 studies included in this scoping review published between 2012 and March 2024, 16 described sensors based on wearable bands, 15 described multisensory systems, and 6 described other strategies to detect tobacco smoke exposure. Included studies provided details about the design or application of wearable sensors based on an elastic band to detect different aspects of tobacco smoke exposure (eg, arm, wrist, and finger movements, and lighting events). Some studies proposed a system composed of different sensor modalities (eg, Personal Automatic Cigarette Tracker [PACT], PACT 2.0, and AutoSense).

Conclusions

Our scoping review has revealed both the obstacles and opportunities linked to wearable devices, offering valuable insights for future research initiatives. Tackling the recognized challenges and delving into potential avenues for enhancement could elevate wearable devices into even more effective tools for aiding smoking cessation. In this context, continuous research is essential to fine-tune and optimize these devices, guaranteeing their practicality and reliability in real-world applications.