bluuebunny/crossref_metadata_2025 huggingface dataset:
THE RS1801282 PPARG POLYMORPHISM DEPENDENT METABOLIC EFFECTS OF PIOGLITAZONE IN PATIENTS WITH OBESITY AND CONCOMITANT NAFLD
Authors: Shypulin Vadym , Rudenko Nikolai , Martynchuk Oleksandr , Koliada Aleksandr , Guryanov Vitaly , Melnyk Nataliia
Published: February 2021

The aim: to investigate the metabolic effects of different treatment options in patients with obesity and concomitant non-alcoholic fatty liver disease (NAFLD) based on the presence of CG and GG genotypes PPARG rs1801282 (Pro12Ala) polymorphism in Ukrainians. Materials and methods: 123 patients with NAFLD in combination with obesity 1, 2, 3 classes were included in the motivational weight loss program (5 visits, 3 months). The case group was treated with pioglitazone 15 mg / day, while the control group received only a program. Ultrasound steatometry, anthropometric and laboratory tests before and after treatment, genetic testing rs1801282 polymorphism in PPARG gene were performed. Results: the carriers of CG and GG genotypes PPARG rs1801282 polymorphism had less high stimulated insulin levels compared with groups of different genotypes (p<0.001). It was found pioglitazone effectiveness with significant difference in dynamics of CAP reduction (p<0.001) regardless of polymorphism. Dynamics of BMI decrease was the lowest in control group CC carries – –2.81 (–3.23; –2.39) kg (p<0.001) compared among other groups. Subjects from pioglitazone group with rs1801282 polymorphism carrying of CG and GG genotypes had significant differences in dynamics of fasting С-peptide decrease, serum uric acid reduction – –1.31 (–1.50; –1.13) µg/L and -165.3 (–182.80; –147.80) µmol/L (p<0.001) respectively compared among other groups. Conclusions: Better reduction of metabolic parameters during pioglitazone treatment of patients with obesity and concomitant NAFLD appears to be associated with carrying of CG and GG genotypes PPARG rs1801282 polymorphism.
On the Use of a TiO2 Sol-Gel for Horseradish Peroxidase Enzyme Immobilization for Development of an Amperometric Biosensor
Authors: da Rocha Carolina , Uliana Carolina , Yamanaka Hideko
Published: February 2021

The sol-gel technique has drawn considerable attention in the area of biomolecules immobilization by virtue of its intrinsic properties including chemical inertness, thermal stability, and good biocompatibility. The present work reports the development of a bio-sensing methodology which involves the immobilization of horseradish peroxidase enzyme (HRP) on pencil graphite electrode (PGE) using TiO2 sol-gel and its application for 5-aminosalicylic acid (5-ASA) determination in pharmaceutical formulations. TiO2 sol-gel film was deposited on the PGE surface by dip coating, and the HRP enzyme was immobilized on the film by adsorption and cross-linked binding using glutaraldehyde. The analytical performance of the methodology was investigated through amperometric measurements at –0.08 V in the presence of 5-ASA (electron mediator) and hydrogen peroxide (substrate). The biosensor was successfully applied for 5-ASA determination, where limits of detection and quantification of 3.3 and 10.0 μmol L-1, respectively, were obtained. The application of the methodology for 5-ASA determination in pharmaceutical formulations led to satisfactory recovery rates ranging from 80 to 98%. The biosensor developed in this work is simple, inexpensive and has the potential to be applied for the determination of other pharmaceutical compounds, which also act as electron mediators in the catalytic cycle of HRP.
Withdrawal Notice: S.A.R.S Covid-19 A Medicinal Chemistry Approach
Authors: Bhardwaj Gautam , Tonk Rajiv Kumar , Garg Harish , Bhalla Vijay
Published: February 2021

The article has been withdrawn at the request of the editor of the journal Mini-reviews in Medicinal Chemistry due to incoherent
content.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously
submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published
elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and
by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action
against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the
copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease
Authors: Zarini-Gakiye Elahe , Vaezi Gholamhassan , Parivar Kazem , Sanadgol Nima
Published: February 2021

Background:

In human tauopathies, pathological aggregation of misfolded/unfolded proteins,
particularly microtubule-associated protein tau (MAPT, tau) is considered to be an essential
mechanism that triggers the induction of endoplasmic reticulum (ER) stress.

Objective:

Here, we assessed the molecular effects of natural antioxidant alpha-lipoic acid (ALA)
in human tauR406W (hTau)-induced ER unfolded protein response (ERUPR) in fruit flies.

Methods:

In order to reduce hTau neurotoxicity during brain development, we used a transgenic
model of tauopathy where the maximum toxicity was observed in adult flies. Then, the effects of
ALA (0.001, 0.005, and 0.025% w/w of diet) in htau-induced ERUPR and behavioral dysfunctions
in the ages 20 and 30 days were evaluated in Drosophila melanogaster.

Results:

Data from expression (mRNA and protein) patterns of htau, analysis of eyes external morphology
as well as larvae olfactory memory were confirmed by our tauopathy model. Moreover,
the expression of ERUPR-related proteins involving Activating Transcription Factor 6 (ATF6), inositol
regulating enzyme 1 (IRE1), and protein kinase RNA-like ER kinase (PERK) wase upregulated
and locomotor function decreased in both ages of the model flies. Remarkably, the lower dose
of ALA modified ERUPR and supported the reduction of behavioral deficits in youngest adults
through the enhancement of GRP87/Bip, reduction of ATF6, downregulation of PERK-ATF4 pathway,
and activation of the IRE1-XBP1 pathway. On the other hand, only a higher dose of ALA affected
the ERUPR via moderation of PERK-ATF4 signaling in the oldest adults. As ALA also exerts
higher protective effects on the locomotor function of younger adults when htauR406Wis expressed
in all neurons (htau-elav) and mushroom body neurons (htau-ok), we proposed that ALA
has age-dependent effects in this model.

Conclusion:

Taken together, based on our results, we conclude that aging potentially influences
the ALA effective dose and mechanism of action on tau-induced ERUPR. Further molecular
studies will warrant possible therapeutic applications of ALA in age-related tauopathies.
Intimate Partner Violence: A Literature Review
Authors: Yonfa Erick D.A. , Fasol Malinda , Cueva Camila M. , Zavgorodniaya Anna C.
Published: February 2021

Background:

Intimate Partner Violence (IPV) is a complex issue that appears to be more prevalent in developing nations. Many factors contribute to this problem.

Objective:

This article aimed to review and synthesize available knowledge on the subject of Intimate Partner Violence. It provides specific information that fills the knowledge gap noted in more global reports by the World Health Organization.

Methods:

A literature search was conducted in English and Spanish in EBSCO and Scopus and included the keywords “Intimate, Partner, Violence, IPV.” The articles included in this review cover the results of empirical studies published from 2004 to 2020.

Results:

The results show that IPV is associated with cultural, socioeconomic, and educational influences. Childhood experiences also appear to contribute to the development of this problem.

Conclusion:

Only a few studies are focusing on empirically validated interventions to solve IPV. Well-implemented cultural change strategies appear to be a solution to the problem of IPV. Future research should focus on examining the results of strategies or interventions aimed to solve the problem of IPV.
An Overview of Removal of Heavy Metal Ions From Toxic Aqueous Solution
Using Pani-Based Adsorbents
Authors: Mohanty Smruti Rekha , Biswal Susanta Kumar
Published: February 2021

:

In the present time, water pollution has become a quibbling issue in the current environmental
engineering and protection senario. The most important aspect of nanocomposite is to
develop economic and bio-friendly route for the synthesis of nanosamples. Various methods such
as ion exchange, reverse osmosis, filtration, adsorption, etc. for removing the metal ions from toxic
water were studied. Among these methods, adsorption technique is widely used due to low cost.
Basically, over the last years, conducting polymer based nanocomposites showed their application
in different heavy metal ions especially Hg (II), Cd(II), Cr(VI), Pb(II), As(V), etc. Among the various
conducting polymers, PANI plays the most important role in extracting the necessary heavy
metal ions. The current review mainly focuses on the synthesis, adsorption and mechanism of different
PANI-based adsorbents like PANI/iron oxide, PANI/ZNO, PANI/GO, and
PANI/CHITOSAN, etc., which extract the heavy metal ions.
Secure Data Validation and Transmission in Cloud and IoT Through Ban
Logic and KP-ABE
Authors: Kumar Narander , Samriya Jitendra Kumar
Published: February 2021

Background:

Cloud computing is a service that is being accelerating its growth in the field of information
technology in recent years. Privacy and security are challenging issues for cloud users and providers.

Obective:

This work aims at ensuring secured validation of user and protects data during transmission for users in a public
IoT-cloud environment. Existing security measures however fails by their single level of security, adaptability for large
amount of data and reliability. Therefore, to overcome these issues and to achieve a better solution for vulnerable data.

Method:

The suggested method utilizes a secure transmission in cloud using key policy attribute based encryption (KPABE). Initially, user authentication is verified. Then the user data is encrypted with the help of KP-ABE algorithm.
Finally, data validation and privacy preservation are done by Burrows-Abadi-Needham (BAN) logic. This verified, and
shows that the proposed encryption is correct, secure and efficient to prevent unauthorized access and prevention of data
leakage so that less chances of data/identity, theft of a user is the analysis and performed by KP-ABE, that is access
control approach.

Results:

Here the method attains the maximum of 88.35% of validation accuracy with a minimum 8.78ms encryption
time, which is better when, compared to the existing methods. The proposed mechanism is done by MATLAB. The
performance of the implemented method is calculated based on the time of encryption and decryption, execution time and
validation accuracy.

Conclusion:

Thus the proposed approach attains the high IoT-cloud data security and increases the speed for validation
and transmission with high accuracy and used for cyber data science processing.
Interfacial fracture behaviour between cement paste and epoxy coating - An experimental and phase-field approach
Authors: Gujar Pratik , Hirshikesh  , Santhanam Manu , Annabattula Ratna Kumar , Ghosh Pijush
Published: February 2021

Surface coatings are mainly applied to protect concrete structures against various environmental conditions. However, the interface between the concrete and coating is a weak link, and interfacial delamination is the primary mode of failure. Fracture resistance is the main design criteria for these materials, and therefore, it is necessary to investigate possible causes of interfacial failure for preventive measures. To this end, we have investigated the potential failure mechanisms and measured interfacial strength by performing a pull-off adhesion test on epoxy coated cement paste. From the pull-off adhesion test, adhesive (interface) failure between cement paste and epoxy is predominantly observed. It is observed that the adhesive (interfacial) strength for the sample tested on 50th day is more than the 28 days hydrated sample. This is due to additional curing of cement paste samples after coating epoxy which leads to higher interfacial strength. We also present the phase-field model (PFM) to predict the adhesive failure for this system. The results obtained from the PFM, i.e., load at failure and crack path are validated against experimental results. Finally, the influence of various material parameters such as elastic modulus and fracture energy of the interface on interfacial fracture behaviour is studied.
Expectations of Continuous Vital Signs Monitoring for Recognizing Complications After Esophagectomy: Interview Study Among Nurses and Surgeons
Authors: van Rossum Mathilde , Leenen Jobbe , Kingma Feike , Breteler Martine , van Hillegersberg Richard , Ruurda Jelle , Kouwenhoven Ewout , van Det Marc , Luyer Misha , Nieuwenhuijzen Grard , Kalkman Cor , Hermens Hermie
Published: February 2021

Background

Patients undergoing esophagectomy are at serious risk of developing postoperative complications. To support early recognition of clinical deterioration, wireless sensor technologies that enable continuous vital signs monitoring in a ward setting are emerging.

Objective

This study explored nurses’ and surgeons’ expectations of the potential effectiveness and impact of continuous wireless vital signs monitoring in patients admitted to the ward after esophagectomy.

Methods

Semistructured interviews were conducted at 3 esophageal cancer centers in the Netherlands. In each center, 2 nurses and 2 surgeons were interviewed regarding their expectations of continuous vital signs monitoring for early recognition of complications after esophagectomy. Historical data of patient characteristics and clinical outcomes were collected in each center and presented to the local participants to support estimations on clinical outcome.

Results

The majority of nurses and surgeons expected that continuous vital signs monitoring could contribute to the earlier recognition of deterioration and result in earlier treatment for postoperative complications, although the effective time gain would depend on patient and situational factors. Their expectations regarding the impact of potential earlier diagnosis on clinical outcomes varied. Nevertheless, most caregivers would consider implementing continuous monitoring in the surgical ward to support patient monitoring after esophagectomy.

Conclusions

Caregivers expected that wireless vital signs monitoring would provide opportunities for early detection of postoperative complications in patients undergoing esophagectomy admitted to the ward and prevent sequelae under certain circumstances. As the technology matures, clinical outcome studies will be necessary to objectify these expectations and further investigate overall effects on patient outcome.
Analisis Tingkat Stres Manusia Terhadap Perubahan Genre Game Dengan Menggunakan Sensor Biofeedback
Authors: Sebastian Chandra , Kusuma Wahyu Andhyka , Wibowo Hardianto
Published: February 2021

Bermain video game merupakan kegiatan rekreasi yang paling populer saat ini, video game merupakan aplikasi interaktif yang melibatkan hubungan antara manusia dengan komputer maupun manusia dengan manusia. pengklasifikasian game yang didasari oleh interaksinya dapat disebut sebagai genre game, begitu banyaknya genre game saat ini, genre game adalah hasil dari perkembangan genre – genre game sebelumnya, contoh dari genre game ialah Action, Adventure, Fighting, Racing, dan Shooter. Namun bukan hanya sebagai sarana rekreasi, game juga mempunyai dampak negatif, dari beberapa penelitian baik dari ilmu psikologi maupun kesehatan, sebagian besar menemukan bahwa stres berkontribusi negatif bagi kesehatan dan dapat mempertinggi peluang seseorang untuk terinfeksi penyakit, stres dapat terjadi ketika sesorang mendapatkan tuntutan atau dihadapkan dengan keadaan yang melebihi kemampuannya, stres dapat dilihat dari respon emosional, perilaku dan respon psikologisnya, Biofeedback adalah metode yang digunakan untuk memperoleh informasi mengenai kondisi tubuh seseorang yang dipengaruhi oleh fungsi fisiologis maupun biologis dari seseorang, sensor biofeedback dapat digunakan untuk mengetahui tingkatan stres manusia terhadap perubahan genre game.
Deteksi Dan Mitigasi Serangan DDoS Pada Software Defined Network Menggunakan Algoritma Decision Tree
Authors: Syahputra Muhammad Qaidin , Akbi Denar Regata , Risqiwati Diah
Published: February 2021

Software Defined Network (SDN) merupakan paradigma baru dalam manajemen jaringan yang memberikan fasilitas untuk melakukan konfigurasi, virtualisasi, dan mengolah infrasturktur jaringan secara terpusat. Manajemen jaringan secara terpusat dilakukan pada SDN Controller yang dimana memisahkan network data plane dari control functions. Serangan Distributed Denial of Service (DDoS) adalah salah satu permasalahan besar dalam kemanan jaringan yang menyebabkan services yang ada pada jaringan menjadi tidak dapat diakses dalam jangka waktu tertentu. Penelitian ini bertujuan untuk membuat sistem deteksi menggunakan algortima Decision Tree dan mitigasi serangan DDoS dengan metode drop packet pada Software Defined Network. Model klasifikasi yang telah dibangun berdasarkan dataset CICIDS 2017 diterapkan pada controller dan kemudian menjadi pendeteksi serangan DDoS jenis User Data Protocol (UDP). Setiap packet in yang masuk ke dalam controller akan melalui proses pendeteksian sebelum diteruskan kepada destination source, adapun jika packet in terdeteksi sebagai serangan DDoS maka controller akan melakukan fungsi mitigasi drop packet terhadap host yang terbukti melakukan penyerangan. Dari percobaan yang telah dilakukan UDP Flood terbukti menghabiskan banyak network resources dan meningkatkan penggunaan CPU sehingga menyebabkan controller mengalami gangguan berfungsi selama proses penyerangan berlangsung. Hasil penelitian ini menunjukkan bahwa sistem yang dibuat berhasil melakukan proses deteksi dan mitigasi  serangan UDP Flood dengan akurasi sebesar 99.95% dan diikuti proses mitigasi dari setiap paket yang terbukti melakukan penyerangan.   Kata kunci: SDN, CICIDS 2017, UDP Flood, Decision Tree, Drop Packet.
PENERAPAN FREQUENCY,RECENCY, MONETERY MODEL DAN ALGORITMA K-MEAN PADA SISTEM PENGELOMPOKAN PELANGGAN (STUDI KASUS: PT. DITRA MANUNGGAL JAYA)
Authors: Wijaya Hussin Agung , Suharso Wildan , Azhar Yufis
Published: February 2021

PT. Ditra Manunggal Jaya yang bergerak dalam bisni Sembilan kebutuhan pokok. Dalam proses bisnisnya PT Ditra Manunggal Jaya masih mengbungkan proses manual dengan transaksi dari pelanggan dari seluruh Indonesia, dengan permasalahan tersebut sangat tidak bisa perusahaan untuk memanajemen pelanggan. Sehingga dibutuhkan suatu sistem yang secara otomatis dapat memanjemen pelanggan. Frequency, recency and monetary model adalah suatu model yang sering diterapkan sebagai pemberian nilai ataupun bobot untuk pelanggan dari proses transaksi. Pemberian bobot yang di berikan akan dianalisa dan dikelompokkan oleh k-mean. Dari hasil analisa k mean diuji menggunakan purity dengan nilai total sebesar 0,441 . dengan pengujian  dapadari fitur pada sistem disimpulkan bahwa sistem dapat dikatakan telah berjalan dengan baik, sehingga dapat membantu staff penjualan PT Ditra Manunggal Jaya dalam memberikan pelayanan yang bai bagi para pelanggannya.
Klasterisasi Citre Liburan Secara Otomatis Berbasis Segmentasi Area Menggunakan Metode K-Means
Authors: Saputro Linggar Bagas , Azhar Yufis , Minarno Agus Eko
Published: February 2021

Mengabadikan momen liburan merupakan hal yang biasa dilakukan wisatawan atau wisatawan domestik. Pada kamera digital citra tersimpan dalam bentuk file yang disimpan pada memori. Dalam memori citra yang tersimpan tidak tertata dengan rapi. Banyak dan beragamnya lokasi atau momen yang diabadikan menyulitkan dalam pengelompokan citra. Dalam hal ini diperlukannya pengelompokan citra liburan untuk mempermudal dalam pengelompokkan citra berdasarkan lokasi. Dataset yang digunakan merupakan dataset citra liburan berjumlah 5000 data dari 49 lokasi wisata. Algoritma yang digunakan dalam penelitian ini adalah K-means. Kmeans merupakan salah satu teknik clustering yang terkenal mudah dan mampu mengklaster data besar dengan cepat. Pada penelitian ini citra disegmentasi menjadi 5 area, segmentasi digunakan pada pengujian untuk membandingkan dengan citra tanpa menggunakan segmentasi, untuk melihat keakuratan yang diperoleh pada penelitian. Penelitian ini dilakukan untuk membuktikan model yang diusulkan mampu mengklaster citra liburan dengan baik. Hal ini dapat dibuktikan bahwa dalam 4 kali pengujian 3 diantaranya model segmentasi 5 lebih unggul  dibandingkan model tanpa segmentasi.
Analisis Quality Of Service (QoS) Protokol MQTT dan HTTP Pada Sistem Smart Metering Arus Listrik
Authors: Nurfiqin Lucky
Published: February 2021

Teknologi mengalami kemajuan yang pesat survei banyak penguna yang memanfaatkan internet untuk kebutuhan sehari-hari salah satunya Internet of Things  (IoT), Dalam Perancangannya  IoT mempunyai beberapa protokol diantaranya Message Queue Telemetry Transport  (MQTT) dan Hyper Text Transport Protocol  (HTTP). Smart meter merupakan suatu perangkat elektronik yang mencatat konsumsi energi listrik dalam waktu tertentu dan mengkomunikasikan informasi tersebut kepada user. Smart meter dapat mengumpulkan data untuk pelaporan jarak jauh. dengan menggunakan protokol MQTT dan HTTP sebagai protokol pengingiriman pesan data untuk Smart meter mengharapkan QoS yang terbaik untuk efisiensi pengiriman data Smart meter . Quality of Service (QoS) adalah metode pengukuran tentang seberapa baik jaringan dan merupakan suatu usaha untuk mendefinisikan karakteristik dan sifat dari satu servis Pengukuran QoS  mempunyai beberapa parameter diantaranya Throughput, Packet Loss, End to End Delay (Latency), dan Jitter Studi kasus untuk penelelitian kali menggunakan sistem monitoring parametering arus listrik. Berdasarkan pengujian yang telah mengimplementasikan menggunakan protokol MQTT dan HTTP selama 10,20 dan 30 menit serta jarak 10,30,50 dan 70 metermendapatkan hasil bahwa protokol MQTT lebih cocok untuk mengirimkan data sensor arus karena MQTT peniriman paket rate lebih cepat dari pada protokol HTTP.1] A. Maulana, E. Suhartono, T. Yunita, F. T. Elektro, and U. Telkom, “Sistem Pengukuran Energi Listrik Pada Smart Energy Meter Untuk Aplikasi Smart House Yang Menggunakan Rooftop Photovoltaic Electrical Energy Measurement System At Smart Energy Meter for Smart House Applications Using Rooftop Photovoltaic,” vol. 6, no. 1, pp. 1047–1054, 2019.[2] M. F. A. Safii, S. Raharjo, and U. Lestari, “Analisis Quality of Service Protokol Mqtt Dan Http Pada Penerapan Sistem Monitoring Suhu Berbasis Nodemcu ( Studi Kasus Ruang Server Kampus 3 Ist Akprind Yogyakarta ),” vol. 7, no. 1, pp. 11–19, 2019.[3] I. Application et al., “Pembuatan Monitoring Real Time Berbasis Web Pada Panel Listrik Di Laboratorium Ppns,” no. 2581, pp. 159–164.[4] R. Wulandari, “ANALISIS QoS (QUALITY OF SERVICE) PADA JARINGAN INTERNET (STUDI KASUS : UPT LOKA UJI TEKNIK PENAMBANGAN JAMPANG KULON – LIPI),” J. Tek. Inform. dan Sist. Inf., vol. 2, no. 2, pp. 162–172, 2016.[5] Hasanul Fahmi, “Analisis Qos (Quality of Service) Pengukuran Delay, Jitter, Packet Lost Dan Throughput Untuk Mendapatkan Kualitas Kerja Radio Streaming Yang Baik,” J. Teknol. Inf. dan Komun., vol. 7, no. 2, pp. 98–105, 2018.
Development of an alloy in the tellurium - copper - cerium system for manufacturing functional coatings for photocathodes of photoelectronic devices
Authors: Vasiliev A. F. , Gyulikhandanov E. L. , Samodelkin E. A. , Farmakovsky B. V.
Published: February 2021

This paper presents the results on the development of an alloy in the tellurium - copper - cerium system used for the manufacture of functional coatings using the technologies of supersonic cold gas-dynamic spraying. Coatings from the specified alloy are used for the manufacture of photocathodes of photoelectronic devices operating in the UV spectral region.
Influence of the initial roughness of the antifriction carbons surface on tribotechnical characteristics and running-in coating efficiency
Authors: Lishevich I. V. , Anisimov A. V. , Savelov A. S. , Sargsyan A. S. , Sobolev M. Yu.
Published: February 2021

The roughness of the friction surface of antifriction carbons used in sliding friction units lubricated with water affects the tribotechnical characteristics during the running-in process. This article experimentally substantiates the range of optimal surface roughness formed during mechanical cutting of carbon plastics in terms of tribotechnical efficiency. The results of a series of tribotechnical tests using various methods under various conditions (contact pressure, sliding speed, counterbody materials) are presented. The relationship between the initial roughness and the effectiveness of a running-in coating based on FORUM® polytetrafluoroethylene powder is established.
LINKING CHRONIC OTITIS MEDIA AND NASAL OBSTRUCTION: A CFD APPROACH
Authors: Olmos Manuel Antonio Burgos , Antunez Alejandro , Romero Rafael , Balbuena Beatriz , Castro David , Pérez Franscisco Piqueras , Ortega Francisco Esteban
Published: February 2021

ABSTRACT OBJECTIVES: To investigate a possible relationship between
altered nasal flow and chronic otitis media (COM) using computational
fluid dynamics (CFD). DESIGN: Retrospective cohort sample of CT scans
from patients with COM and controls without COM to compare the results
of various nasal airflow parameters determined by CFD between a group of
patients with COM (N=60) and a control group of subjects without any
evidence of ear disease (N=81). MAIN OUTCOME MEASURES: The CT were
subjected to various procedures to carry out CFD studies, determining
the resistance to nasal flow, the proportion of flow through the right
and left nasal cavity, and two nondimentional estimators. The results of
CFD studies between patients with COM and controls were compared.
RESULTS AND CONCLUSIONS: Whereas only 12.3% of the controls had CFD
alteration (10 out of 81), 43.3% of the patients suffering COM
displayed alterations of our nondimentional parameters (26 out of 60).
According to our results, the incidence of alterations in nasal airflow
by studying with CFD is significantly higher in patients with COM than
in controls IMPLICATIONS: To our knowledge, this is the first paper
linking nasal cavity and COM using a CFD approach. Our results support
the hypothesis that nasal flow alterations could be implicated in the
etiopathogenesis of the COM.
Lead extractions: dissecting adhesions up to the lead-tip of the right ventricle: safety and success-rates
Authors: Witte Olivier , Delnoy Peter , Ghani Abdul , Smit Jaap Jan , Misier Anand Ramdat , Elvan Arif , Adiyaman Ahmet
Published: February 2021

Objectives and Background: Goal of Transvenous Lead Extraction (TLE) is
complete removal of all targeted leads, without complications. Despite
counter traction manoeuvres, efficacy rates are often hampered by broken
right ventricle lead (RV-lead) tips. Mechanically powered lead
extraction (Evolution sheath) is effective, however safety of dissection
up to the lead tip is unclear. Therefore, we examined the feasibility
and safety of RV-lead extraction requiring dissection up to the
myocardium. Methods and results: From 2009 to 2018, all TLE in the Isala
Heart Centre (Zwolle, The Netherlands) requiring the hand-powered
mechanical Evolution system to extract RV-leads (n=185) were examined
from a prospective registry. We assessed 2 groups: TLE with the first
generation Evolution (n=43) with (A1,n=18) and without (A2,n=25)
adhesions up to the myocardium and TLE with the Novel R/L type (n=142)
of sheath with (B1,n=59) and without (B2,n=83) adhesions up to the
myocardium. Complete success rate in Group B was significantly higher
than group A (96.5 vs 76.7%, p=0.0354). When comparing the patients
with adhesions up to the myocardium, total complete success is higher in
the R/L group (61.1% vs 90.5%, p=0.0067). There were no deaths.
Overall major complication rates were low (2/185;1.1%) and there was no
statistically significant difference in major and minor complications
between the two groups. Conclusion: Extraction strategy with the
bidirectional Evolution R/L sheath for right ventricular leads with
adhesions up to the myocardium is safe and feasible.
Epstein-Barr virus induced sickle hepatopathy
Authors: Towerman Alison , Wilson David , Hulbert Monica
Published: February 2021

Sickle hepatopathy comprises a spectrum of disorders that vary in
severity. Intravascular sickling and sinusoidal occlusion are the
principal drivers of sickle hepatopathy, but infection or autoimmunity
may act as triggers. We describe two cases of acute sickle hepatopathy
initiated by primary Epstein-Barr virus (EBV) infection, a previously
unreported association. The first case entailed a 14-year-old girl with
hemoglobin SC (HbSC) disease who developed hepatic sequestration crisis
that responded to a simple transfusion of erythrocytes. The second case
was that of a 16-year-old boy with HbSC disease who experienced
life-threatening intrahepatic cholestasis with multi-organ failure.
Gender Differences in Access to Health Care Among the Elderly: Evidence from Southeast Asia
Authors: Rodgers Yana van der Meulen , Zveglich, Jr. Joseph E.
Published: February 2021

This paper examines gender among other factors that may constrain older persons in Southeast Asia from meeting their health-care needs when sick based on data from Cambodia, the Philippines and Viet Nam. It finds that while women in Cambodia and the Philippines are more likely to seek treatment than men, the gender difference is reversed in Viet Nam where stigma associated with some diseases may more strongly deter women than men. Household survey data from these countries show that the probability of seeking treatment rises with age more sharply for women than men. Yet, for the subsample of elders, the gender difference is not significant.
Placemaking: elements of critical regionalism in the architecture of Mihailo Timotijevic
Authors: Malesevic Milica , Milic-Aleksic Maja
Published: February 2021

Using elements derived from what marks a place as singular is key to
contemporary placemaking, understood as a primary objective of the theory of
critical regionalism. The need to create humane, remarkably local
architecture and to minimize the effects of universal and international
clich?s, in order to avoid the danger of making architecture locally
unfounded and to invest it with meaning and a sense of place, certainly
poses a challenge for every modern architect. This paper deals with the
issue of contextuality and approach to the character and urban matrix of a
place, as characterizing the buildings in the Western Serbian city of Uzice
designed by architect Mihajlo Timotijevic. A critical approach is adopted in
analyzing Timotijevic?s architectural plans and buildings constructed in
Uzice, in the attempt to show that the architect takes a genuine interest in
the local topography and that which is called placemaking. The main goal of
this research is to underline the fact that Timotijevic?s ability to
perceive and read the messages sent by a place, materialize its
distinctivness and easily incorporate a "sense of place" in architectural
spaces has given the city of Uzice a new image, by integrating the spirit of
the regional with that of the contemporary. The research results are
particularly pertinent to contemporary architectural theory and practice,
both in Serbia and the region, as a comprehensive, multifaceted example of a
good practice of critical regionalism.
Revitalization as protection instrument of cultural heritage of libraries
Authors: Koca-Baltic Ilda , Momcilovic-Petronijevic Ana
Published: February 2021

Superior information technology and global network coverage - the Internet,
have raised the issue of sustainability and library facilities in the 21st
century. Architects across the globe endeavor to examine and improve the
traditional concepts of designing a library in accordance with the complex
needs of the contemporary society. In this paper, the tools for development
and protection of the library buildings in the information age are
presented. The goal is to shed light on the complex process of revitalizing
the libraries that today, more than ever, are fighting for sustainability.
In this endeavor, an analysis of the case study of some of the
world-renowned libraries will be of particular importance.
Use of color in architecture - industrial architecture perspective
Authors: Jevremovic Ljiljana , Turnsek Branko , Stanojevic Ana , Jordanovic Marina , Vasic Milanka
Published: February 2021

This paper deals with the color theory and the application of this theory in
architectural design. Since the modernist architects and modern era in
architecture, the colors of the buildings were not in the focus of their
authors. On the contrary, the modern movement has taught us that color, and
especially artificial one, is almost a crime to use and in a way, it
expresses a lack of a style. Through examining universal color harmony
principles in this paper the problem and phenomenon of using colors in
contemporary architecture was discussed, which had its roots in the modern
movement and evolved through technological advance especially in material
technology. The industrial architecture is used as an example, to narrow down
the research field, but also for the reasons of extensive and creative use of
color in this type of buildings. We have examined several industrial
buildings that have been systematized into three categories. All three
categories are analyzed for the application of general color harmony
principles. Then discussion focuses on refining principles of color usage in
architecture that appear in contemporary architecture in order to systematize
those principles, particularly important for architectural education and new
practitioners of architecture. In conclusion, it is stated that universal
color harmony principles are applicable in architecture as well, as in other
visual arts.
Inflammatory cardiovascular risk markers and silent myocardial ischemia in type 2 diabetic patients
Authors: Malesevic Gabrijela , Popovic-Pejicic Snjezana , Markovic Aleksandra , Soldat-Stankovic Valentina
Published: February 2021

Background/Aim. A special feature of coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM) is that it is often a symptomatic and occurs as a consequence of cardiovascular autonomic neuropathy. Dysregulation of the autonomic nervous system is associated with elevated values of inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) and interleukin- 6 (IL-6), which accelerate atherosclerosis and the occurrence of cardiovascular complications in patients with T2DM. The aim of the study was to evaluate the importance of determining inflammatory cardiovascular risk markers IL-6 and hs-CRP in screening for the presence of CHD in asymptomatic patients with T2DM. Methods. The study included 169 patients with T2DM without any symptoms and signs of CHD. Ergometric testing proved or ruled out the presence of silent CHD. The levels of hs- CRP and IL-6 were determined by ELISA. Results. IL-6 values were significantly higher in patients with a positive ergometric test (6.83 ? 1.99 pg/mL) compared to patients with a negative ergometric test (3.04 ? 1.39 pg/mL) (p < 0.001). We also found that hs-CRP values in patients with a positive ergometric test were significantly higher compared to patients with a negative ergometric test (6.37 ? 2.25 vs 1.67 ? 1.41 mg/L; p < 0.001). Combinations of IL-6 and hs-CRP with age, HbA1c values, and duration of diabetes, presented through three binary logistic regression models, are significant predictors of silent CHD proven by ergometric testing, ie, with their increase, the probability of a positive ergometric test also increases (p < 0.01). The sensitivity of the associated finding of elevated IL-6 and hs-CRP values in the detection of silent CHD by ergometric testing was 90%, and the specificity was 86%. Conclusion. Hs-CRP and IL-6 are significant predictors of silent CHD, and their determination could be recommended for improving cardiovascular risk stratification in asymptomatic patients with T2DM.
G-α-preinvex functions and non-smooth vector optimization problems
Authors: Chen Yu
Published: February 2021

In this paper, we proposed the non-smooth G-?-preinvexity by generalizing
?-invexity and G-preinvexity, and discussed some solution properties about
non-smooth vector optimization problems and vector variational-like
inequality problems under the condition of non-smooth G-?-preinvexity.
Moreover, we also proved that the vector critical points, the weakly efficient
points and the solutions of the non-smooth weak vector variational-like
inequality problem are equivalent under non-smooth pseudo-G-?-preinvexity
assumptions.
Evaluation of Clinical Outcomes With the V-Go Wearable Insulin Delivery Device in Patients With Type 2 Diabetes
Authors: Meade Lisa T. , Battise Dawn
Published: February 2021

Uncontrolled type 2 diabetes can lead to a multitude of health complications. Insulin therapy is recommended when patients are unable to reach their A1C goal with oral or noninsulin injectable diabetes medications. This study evaluated the clinical benefits of switching from multiple daily insulin injections to a wearable insulin delivery device (V-Go). A retrospective chart review was conducted on 44 patients who received prescriptions for the V-Go at two family medicine offices. Investigators found a significant reduction in A1C and daily insulin requirements with no impact on weight or BMI.
Improved Glycemic Outcomes With Medtronic MiniMed Advanced Hybrid Closed-Loop Delivery: Results From a Randomized Crossover Trial Comparing Automated Insulin Delivery With Predictive Low Glucose Suspend in People With Type 1 Diabetes
Authors: Collyns Olivia J. , Meier Renee A. , Betts Zara L. , Chan Denis S.H. , Frampton Chris , Frewen Carla M. , Hewapathirana Niranjala M. , Jones Shirley D. , Roy Anirban , Grosman Benyamin , Kurtz Natalie , Shin John , Vigersky Robert A. , Wheeler Benjamin J. , de Bock Martin I.
Published: February 2021

OBJECTIVE

To study the MiniMed Advanced Hybrid Closed-Loop (AHCL) system, which includes an algorithm with individualized basal target set points, automated correction bolus function, and improved Auto Mode stability.

RESEARCH DESIGN AND METHODS

This dual-center, randomized, open-label, two-sequence crossover study in automated-insulin-delivery–naive participants with type 1 diabetes (aged 7–80 years) compared AHCL to sensor-augmented pump therapy with predictive low glucose management (SAP + PLGM). Each study phase was 4 weeks, preceded by a 2- to 4-week run-in and separated by a 2-week washout.

RESULTS

The study was completed by 59 of 60 people (mean age 23.3 ± 14.4 years). Time in target range (TIR) 3.9–10 mmol/L (70–180 mg/dL) favored AHCL over SAP + PLGM (70.4 ± 8.1% vs. 57.9 ± 11.7%) by 12.5 ± 8.5% (P < 0.001), with greater improvement overnight (18.8 ± 12.9%, P < 0.001). All age-groups (children [7–13 years], adolescents [14–21 years], and adults [>22 years]) demonstrated improvement, with adolescents showing the largest improvement (14.4 ± 8.4%). Mean sensor glucose (SG) at run-in was 9.3 ± 0.9 mmol/L (167 ± 16.2 mg/dL) and improved with AHCL (8.5 ± 0.7 mmol/L [153 ± 12.6 mg/dL], P < 0.001), but deteriorated during PLGM (9.5 ± 1.1 mmol/L [17 ± 19.8 mg/dL], P < 0.001). TIR was optimal when the algorithm set point was 5.6 mmol/L (100 mg/dL) compared with 6.7 mmol/L (120 mg/dL), 72.0 ± 7.9% vs. 64.6 ± 6.9%, respectively, with no additional hypoglycemia. Auto Mode was active 96.4 ± 4.0% of the time. The percentage of hypoglycemia at baseline (<3.9 mmol/L [70 mg/dL] and ≤3.0 mmol/L [54 mg/dL]) was 3.1 ± 2.1% and 0.5 ± 0.6%, respectively. During AHCL, the percentage time at <3.9 mmol/L (70 mg/dL) improved to 2.1 ± 1.4% (P = 0.034) and was statistically but not clinically reduced for ≤3.0 mmol/L (54 mg/dL) (0.5 ± 0.5%; P = 0.025). There was one episode of mild diabetic ketoacidosis attributed to an infusion set failure in combination with an intercurrent illness, which occurred during the SAP + PLGM arm.

CONCLUSIONS

AHCL with automated correction bolus demonstrated significant improvement in glucose control compared with SAP + PLGM. A lower algorithm SG set point during AHCL resulted in greater TIR, with no increase in hypoglycemia.
Improved Glycemic Outcomes With Medtronic MiniMed Advanced Hybrid Closed-Loop Delivery: Results From a Randomized Crossover Trial Comparing Automated Insulin Delivery With Predictive Low Glucose Suspend in People With Type 1 Diabetes
Authors: Collyns Olivia J , Meier Renee A , Betts Zara L , Chan Denis SH , Frampton Chris , Frewen Carla M , Hewapathirana Niranjala M , Jones Shirley D , Roy Anirban , Grosman Benyamin , Kurtz Natalie , Shin John , Vigersky Robert A , Wheeler Benjamin J , Bock Martin I de
Published: February 2021

Objective:

To study the MiniMed™ Advanced Hybrid Closed-Loop system (AHCL) which includes
an algorithm with individualised basal target set points, automated correction
bolus function, and improved Auto Mode stability.

Research design and Methods:

This dual-centre, randomized, open-label, two-sequence
cross-over study in automated insulin delivery naïve participants with type 1
diabetes (aged 7-80yrs), compared AHCL to Sensor Augmented Pump therapy with
Predictive Low Glucose Management (SAP+PLGM). Each
study phase was 4 weeks, preceded by a 2-4 week run-in, and separated by 2-week
washout.

Results:

59/60 people completed the study (mean age 23.3±14.4yrs). Time in target range
(TIR) 3.9-10mmol/L (70-180 mg/dL) favoured AHCL over SAP+PLGM (70.4±8.1 vs 57.9±11.7) by
12.5±8.5% (p<0.001), with greater improvement overnight (18.8±12.9%,
p<0.001). All age groups (children (7 – 13 years), adolescents (14 – 21
years), and adults (>22 years) demonstrated improvement, with adolescents
showing the largest improvement (14.4±8.4%). Mean sensor glucose (SG) at run in
was 9.3±0.9 mmol/L (167±16.2mg/dL) and improved with AHCL (8.5±0.7mmol/L (153±12.6mg/dL)
(p < 0.001)), but deteriorated during PLGM (9.5±1.1mmol/L (17±19.8mg/dL),
(p<0.001)).. TIR was optimal when the algorithm set point was 5.6 mmol/L
(100 mg/dL) compared to 6.7 mmol/L (120 mg/dL), 72.0±7.9% vs 64.6±6.9%
respectively with no additional hypoglycemia. Auto Mode was active 96.4±4.0% of
the time. The percentage of hypoglycemia at
baseline (<3.9mmol/L (70mg/dl) and  £
3.0mmol/L(54mg/dl)) was 3.1±2.1% and 0.5±0.6%
respectively. During AHCL percentage time <3.9mmol/L (70mg/dl) improved to 2.1±1.4% (p=0.034) (70mg/dl), and was
statistically but not clinically reduced for £ 3.0mmol/L(54mg/dl) (0.5±0.5%, p = 0.025) There
was one episode of mild diabetic ketoacidosis attributed to an infusion set
failure in combination with an intercurrent illness, which occurred during the
SAP+PLGM arm.

Conclusions

AHCL with automated correction bolus demonstrated significant
improvement in glucose control compared to SAP+PLGM. A lower algorithm sensor
glucose set point during AHCL resulted in greater TIR, with no increase in
hypoglycemia.
6013-T6 Alüminyum Alaşımlarının Sürtünme Karıştırma Nokta Kaynağına Takım Bekleme Süresinin Etkisi
Authors: YÜRÜK Ali
Published: February 2021

Alüminyum ve alaşımları (Al ve alş.) yüksek korozyon direnci ve iyi mekanik özelliklere sahip olmalarının yanında ağırlık olarak da çeliğe göre daha hafif olmaları, sanayi üretiminde tercih edilir hale gelmesine neden olmuştur. Yoğun bir şekilde kullanım alanının artması al ve alş. farklı konum ve şekillerde kaynak ile birleştirilmesini zorunlu hale getirmiştir. Üretimde alüminyum malzemeleri ile üretilen kaynak uygulamalarında alın alına birleştirme ve bindirme şeklindeki birleştirmeler ön plana çıkmaktadır. Ancak alüminyum malzemelerin bindirme biçiminde birleştirilebileceği kaynak yöntemleri lazer ve nokta direnç kaynağı yöntemleri ile sınırlıdır. Belirtilen her iki kaynak yöntemi de ergitmeli kaynak yöntemi olduğundan her zaman kullanılmaları mümkün değildir. Bu nedenle, bu çalışmada 6013 al ve alş. sürtünme karıştırma nokta kaynak yöntemi (SKNK) ile 2000 dev/dk devir sayısında ve 30, 45, 60 sn takım bekleme sürelerinde birleştirilmiştir. Daha sonra kaynaklı birleştirmelerin mekanik ve mikroyapı özelliklerinde meydana gelen değişikliklerin belirlenmesi için çekme deneyi, sertlik ölçümleri ve mikroyapı çalışmaları gerçekleştirilmiştir.
AN ANALYSIS OF LIBERAL FEMINISM IN THE NOTEBOOK NOVEL (1996) BY NICHOLAS SPARKS
Authors: Gunawati Pande Made , Tantra Dewa Komang , Juniarta Putu Adi Krisna
Published: February 2021

In The Notebook by Nicholas Sparks, Allison Nelson was characterized as an inspiring woman who fought for her dreams. Meanwhile, Noah Calhoun was described as a loving man that respected Allison as a woman. This novel contained traits of rich liberal feminism. The purpose of the present research was to find out the traits of Noah Calhoun and Allison Nelson as the main characters that represented liberal feminism in the novel. The method of this research was textual analysis to analyze the traits. Data collection was linguistics unit corpora recorded in written forms. The finding of this research can be stated that Noah Calhoun and Allison Nelson were categorized as liberal feminists. Their traits were a combination of positive feminine and masculine traits. The traits of the main characters as liberal feminists were appreciative, forceful, strong, devoted, firm, sensitive, confident, patient, carefree, responsible, and independent.
Effects of removing a fee-for-service incentive on specialist chronic disease services: a time-series analysis
Authors: Appleton Andrew , Lam Melody , Le Britney , Shariff Salimah , Gershon Andrea
Published: February 2021

Introduction

Physician payment models are known to affect the nature and volume of services provided. Our objective was to study the effects of removing a financial incentive, the fee-for-service premium, on the provision of chronic disease follow-up services by internal medicine, cardiology, nephrology and gastroenterology specialists.

Methods

We collected linked administrative health care data for the period 1 April 2013 to 31 March 2017 from databases held at the Institute for Clinical Evaluative Sciences (ICES) in Ontario, Canada. We conducted a time-series analysis before and after the removal of the fee-for-service premium on 1 April 2015. The primary outcome was total monthly visits for chronic disease follow-up services. Secondary outcomes were monthly visits for total follow-up services and new patient consultations. We compared internal medicine, cardiology, nephrology and gastroenterology specialists practising during the study timeframe with respirology, hematology, endocrinology, rheumatology and infectious diseases specialists who remained eligible to claim the premium. We chose this comparison group as these are all subspecialties of internal medicine, providing similar services.

Results

The number of chronic disease follow-up visits decreased significantly after removal of the premium, but there was no decrease in total follow-up visits. There was also a significant downward trend in new patient consultations. No changes were observed in the comparison group.

Conclusion

The decrease in volume of chronic disease follow-up visits can be explained by diagnostic criteria being met less often, rather than an actual reduction in services provided. Potential effects on patient outcomes require further exploration.