bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicando pesquisa operacional no contexto de uma microempresa de serviços de beleza
Authors: Ramos Pamela Adelino , Melo Marina Fonseca Martins de , Gonçalves Helen Silva
Published: January 2023

Este artigo utiliza a Pesquisa Operacional para a maximização de lucros e melhoria da tomada de decisão em uma microempresa de serviços de beleza através da aplicação de programação linear. A pesquisa classifica-se como aplicada, exploratória e quantitativa por meio de estudo de caso. A coleta dos dados foi realizada através de entrevista para identificar as variáveis de decisão, função objetivo e restrições do sistema. O modelo foi inserido em planilha eletrônica com resolução através do Solver. As variáveis de decisão foram definidas como a quantidade de cada um dos diferentes serviços a serem realizados. As restrições identificadas dizem respeito ao horário de funcionamento, horário inicial, atendimento da clientela fiel, limitação da mão de obra e demandas máximas de cada serviço. A solução ótima mostrou que a receita mensal da empresa pode aumentar em 206%. Recomenda-se manter ou aumentar as demandas máximas dos serviços cujas restrições não têm folga, conseguir demanda para o horário ocioso e reavaliar o preço dos serviços das variáveis não básicas. A pesquisa demonstrou a relevância da aplicação de PO em micro e pequenas empresas, e o impacto financeiro que podem produzir.
Manutenção preventiva em ambientes hospitalares
Authors: Santos Jeferson Luis Andreoli dos , Azambuja Marcelo Schenk de
Published: January 2023

Objetivo: identificar e caracterizar os aspectos mais relevantes da gestão para a realização de manutenções preventivas em ambientes hospitalares. Método: realizar uma revisão integrativa da literatura com busca nas bases de dados Web of Science, SCOPUS e Science Direct, com os seguintes descritores: "preventive maintenance" AND hospital. Incluídos os artigos originais, os de revisão e ospublicados em congressos entre 2016 a 2021, nos idiomas português, inglês e espanhol, e que respondessem à questão norteadora. Resultados: Foram incluídos 17 artigos, sendo que todos foram publicados em inglês e originados em diversos países. Houve um maior número de publicações nos últimos três anos, de forma crescente. A revista Journal of Building Engineering foi a com mais publicações, sendo cinco no total. Conclusão: Os estudos analisados nesta revisão apresentam soluções e ferramentas que auxiliam e norteiam as manutenções hospitalares, foram destacados as ferramentas e aspectos mais relevantes os seguintes: a confiabilidade, os critérios de desempenho, a disponibilidade, os impactos na assistência, os custos, a cultura de manutenção corretiva, a periodicidade e a forma de gestão por software.
Gestão da qualidade
Authors: Lima Paulo Ricardo Fernandes de
Published: January 2023

A adoção de certificações de qualidade configura-se como uma das medidas mais requisitadas para o crescimento interno de empresas. Entretanto, este processo mostra-se árduo e desafiador. Neste contexto, o presente trabalho buscou traçar um panorama de empresas brasileiras nordestinas certificadas com a ISO 9001 no que tange às motivações, dificuldades e benefícios com a implantação. A pesquisa norteou-se primeiro com um levantamento bibliográfico em livros, artigos e periódicos sobre Engenharia da Qualidade, com foco na certificação ISO 9001. Aplicou-se questionários a empresas para levantamento de dados. Elas estavam listadas no Certifiq/Inmetro e no Comitê Brasileiro de Qualidade (ABNT/CB-25). Por suas características, a pesquisa classifica-se como bibliográfica, quantitativa, aplicada, survey, descritiva. Para o tratamento dos dados, utilizou-se os indicadores estatísticos de média ponderada, moda, mediana, Alfa de Cronbach e Coeficiente de Correlação de Pearson, além da ferramenta MS Excel, versão 2013. Enviou-se questionários a 208 empresas, com uma taxa de retorno de 32,7%. Concluiu-se que as maiores motivações empresariais para a certificação de qualidade foram: busca por melhoria de qualidade de produtos, melhorias na gestão de processos e obtenção de vantagens de mercado. As principais dificuldades foram as resistências dos funcionários às mudanças, excesso de burocracia e escassez de recursos. Em contrapartida, os benefícios centraram-se em ganhos na gestão de qualidade, redução de erros/defeitos/retrabalho e maior força nas ações de marketing e publicidade.
Séries temporais e variáveis qualitativas
Authors: De Senna Viviane , Souza Adriano Mendonça , Ueda Renan Mitsuo
Published: January 2023

As variáveis qualitativas possuem características de influenciar variáveis quantitativas. As séries temporais são exemplo de variáveis quantitativas que podem ser modificadas por alterações abruptas de variáveis qualitativas. O objetivo desta pesquisa é identificar uma lacuna de conhecimento entre modelos de previsão de séries temporais e variáveis qualitativas por meio deuma revisão sistemática de literatura aplicada em artigos científicos publicados em bases internacionais. Foram encontrados 37 artigos que unem séries temporais e variáveis qualitativas no período de 1985 a 2020, nos quais novos modelos foram criados utilizaram as variáveis qualitativas como entradas de informação para a geração de previsões. A lacuna encontrada foi em aproximados 57% dos casos a capacidade de melhoria dos modelos criados e a aplicação em outros sistemas, e em 19% a possibilidade de melhorar a previsão de outras variáveis do sistema. Os resultados indicaram que a inclusão de variáveis qualitativas em modelos quantitativos auxilia na qualidade da precisão das previsões geradas.
Contribuições da implementação do passo 1 do pilar de segurança do WCM
Authors: Silva Maria Adriele da , Gonçalves Anderson Tiago Peixoto
Published: January 2023

O Brasil é o quarto país em números de acidentes laborais, portanto, estabelecer procedimentos que possibilitem uma maior segurança dos colaboradores é primordial para as empresas, dentre as quais as do setor da construção civil, principal responsável por estas altas taxas. O World Class Manufacturing - WCM é uma metodologia que busca a excelência operacional nas organizações, que se baseia em pilares gerenciais e técnicos, dentre os quais o de segurança. Assim, o presente estudo tem como objetivo analisar as contribuições da implementação do passo 1 do pilar de segurança da metodologia WCM no subsetor de distribuição de materiais de uma construtora de habitação popular. Trata-se de uma pesquisa aplicada, quali-quanti, exploratória, descritiva e documental, que assumiu o formato de estudo de caso. A implementação do passo 1 do pilar de segurança possibilitou, no período compreendido entre os anos de 2018 e 2020, uma redução no número de acidentes ocorridos na empresa de 18 para 03.
Aplicação de aprendizado de máquina para aumento de precisão de um sistema automatizado de nutrição de suínos
Authors: Dal Bo Giuliano , Corso Leandro Luiz
Published: January 2023

Com a constante evolução computacional, a viabilidade de implementação de modelos de aprendizado de máquina vem se desenvolvendo em diversas áreas de atuação. Uma das áreas de grande relevância para o desenvolvimento econômico nacional é o agronegócio, e dentre suas subáreas, a suinocultura apresenta parcela representativa para o mercado. Dentre as rubricas de custo da suino cultura, a que tem maior representatividade e necessidade de controle preciso é o consumo de ração. Visando o aumento da precisão de um sistema automatizado de nutrição de suínos, este artigo tem como objetivo, demonstrar uma composição de modelo supervisionado de inteligência artificial para previsão das variáveis mais relevantes para atingir o menor erro possível entre a dosagem programa e a dosagem realizada pelo equipamento. O modelo de aprendizado de máquinaconsiderado é de regressão linear. Para verificação da acuracidade e performance do modelo são utilizadas as principais métricas de erro de análises quantitativas. Os resultados apresentados no artigo indicam que o modelo de aprendizado de máquina do tipo regressão linear consegue uma melhor generalização da variável a ser prevista e pode reduzir o erro absoluto da dosagem de cada ciclo de trato dos animais em média 7,4 vezes.
Utilização da simulação computacional por eventos discretos e otimização para a programação da produção em uma empresa da indústria de plásticos
Authors: Piacentini Cristina Fabbris , Gauss Leandro , Morandi Maria Isabel Wolf Motta , Lacerda Daniel Pacheco
Published: January 2023

Com a globalização e a crescente competitividade do mercado, as empresas precisam se manter em constante inovação e melhorando a eficiência dos processos. O problema que esse trabalho busca resolver é o elevado custo gerado pela ineficiência da programação. Dessa forma, o objetivo é propor a redução de custos por meio da diminuição dos estoques de materiais em processo, a fim de melhorar o planejamento da ocupação das máquinas, distribuir as manutenções preventivas e facilitar a tomada de decisões. Para isso, foi utilizada a simulação computacional por eventos discretos e otimização, por meio do software AnyLogic, para definir o cenário de melhor combinação das variáveis de decisão. Como resultado, foi possível verificar no cenário a possibilidade de se produzir além da demanda, e ainda reduzir 96% dos estoques em processo. Desta forma, a nível gerencial, foi possível analisar as alternativas, identificar possíveis falhas, corrigi-las e definir aquela que melhor atendeu às necessidades estratégicas da empresa. Isso considerando a possibilidade de ocorrência de eventos aleatórios e sem a necessidade de parar o funcionamento da fábrica para a realização de testes. A nível acadêmico, esse artigo agrega em estudos de simulação-otimização que consideram dados reais.de uma produção MTS.
Role of Cinnamon Supplementation on Glycemic Markers, Lipid Profile and Weight Status in Patients with Type II Diabetes
Authors: Talaat Sazan M.
Published: January 2023

Type II diabetes has been on the rise for the past few decades and the current management plan of diabetes is challenging to individuals in keeping their blood glucose levels within normal limits. There is a constant search of new ways to tackle these challenges. Cinnamon is suggested to have antihyperglycemic and lipid lowering effect and has been proposed to be utilized in type II diabetes. The aim behind this review is to explore the role of cinnamon in improving the glycemic status, lipid profile, and weight status of patients with type II diabetes. PubMed and ScienceDirect databases have been searched for eligible studies conducted until February 2022, the outcomes measured were glycemic markers as primary outcome and lipid profile and weight status as secondary outcomes. A total of ten trials involving 861 patients were included in the study. Five studies have demonstrated reductions in glycemic markers (ranging between −0.56 and −1.9 mmol/L for fasting blood sugar and between −0.21% and −0.93% for glycated hemoglobin) whereas the remaining four did not show any significant reduction. The most improvements in glycemic markers are seen in patients with poorly controlled diabetes and patients with higher body mass index (BMI) values. The majority of the studies did not record improvement in lipid profile. Changes in weight status are only observed in overweight patient category (BMI between 25 and 30). Overall, there is no coherent evidence to decide about antihyperglycemic, lipid lowering, and weight reducing effects of cinnamon in type II diabetes.
The impact of mismatched recordings on an automatic-speaker-recognition system and human listeners
Authors: Nechanský Tomáš , Bořil Tomáš , Houzar Alžběta , Skarnitzl Radek
Published: January 2023

The so-called ‘mismatch’ is a factor which experts in the forensic voice comparison field encounter regularly. Therefore, we decided to explore to what extent the automatic-speaker-recognition system’s and the earwitness’ ability to identify speakers is influenced when recordings are acquired in different languages and at different times. 100 voices in a database of 300 recordings (100 speakers recorded in three mutually mismatched sessions) were compared with an automatic-speaker-recognition software VOCALISE based on i-vectors and x-vectors, and by 39 respondents in simulated voice parades. Both the automatic and perceptual approach seem to have yielded similar results in that the less complex the mismatch type, the more successful the identification. The results point to the superiority of the x-vector approach, and also to varying identification abilities of listeners.
The dynamic effect of speaking fast on speech prosody
Authors: Tavi Lauri
Published: January 2023

Speaking fast causes several changes in speech prosody. In addition, it can be associated with a decrease in speech intelligibility. In this study, prosodic changes in fast speech were investigated using common prosodic measurements and syllabic prosody index (SPI), a novel prominence measure that combines f0, energy and duration features. Dynamic changes in long-term prosodic prominence were investigated using functional data analysis (FDA), in which the SPI is transformed into a functional form. The possibly decreasing effect of speaking fast on speech intelligibility was evaluated using automatic speech recognition. Phonetic analyses of syllabic units showed that speaking fast decreases duration, f0 and SPI, and increases articulation rate and proportional acoustic energy in the frequency range of 0–1 kHz. FDA supported the aforementioned results by revealing dynamically decreased overall prominence in fast speech. Furthermore, in comparison to regular speech, speech intelligibility was found to be significantly lower in fast speech: word error rate (WER) for regular speech was 0.27, whereas for fast speech it was 0.86.
In-vitro Bioevaluation, Pharmacokinetics and Molecular Docking Study of unexplored Bisabolol-rich Curcuma inodora essential oil from Konkan region: A biodiversity hotspot
Authors: Nagore Pravinkumar , Lokhande Popat , Mujawar Haniph
Published: January 2023

Curcuma inodora Blatt., belonging to the Zingiberaceae family is an endemic species from peninsular India. The extraction and some of the biological applications of leaves essential oil of this species had been reported from South India. Although the Konkan region is a biodiversity hotspot, no report on the medicinal applications of essential oils in this species is available to date. Herein, the ?–Bisabolol-rich rhizome essential oil from wild C. inodora was isolated by the hydrodistillation method and characterized by Gas Chromatography-Flame ionization detector (GC/ GC-FID) and Gas Chromatography High-resolution mass spectrometry (GC/HRMS) techniques for pharmacokinetics and molecular docking applications. The Hydrodistillation extract (HDREO) constituted 11 components with a major constituent, ?- Bisabolol (62.13%). In-vitro anti-bacterial, anti-fungal, anti-oxidant, and anti-inflammatory potential of rhizome oils were carried out. The pharmacokinetics of the major component, ?-Bisabolol, like high GI absorption, zero Lipinski violation with good bioavailability score, etc. support its candidacy as a drug. Further, docking was performed with the principal component ?- Bisabolol. The least binding energy conformation of ?–Bisabolol with anti-bacterial (3WGN.pdb), anti-fungal (1IYL.pdb), anti-oxidant (3MNG.pdb) and anti-inflammatory (1CX2.pdb) proteins were reported to be -7.01 kcal/mol, -8.15 kcal/mol, -7.82 kcal/mol, and –7.71 kcal/mol respectively. This shows, the significant binding affinity of ?–Bisabolol with proteins. So, the rhizome oil of this unexplored species can be utilized in developing novel phytopharmaceuticals and medicines after further study. To the best, this is a foremost report on the rhizome essential oil isolation by hydrodistillation method, its characterization, and its bio-evaluation with pharmacokinetics and docking applications of this species.
Social Representations of Political Polarization through Traditional Media: A Study of the Brazilian Case between 2015 and 2019
Authors: Giacomozzi Andréia Isabel , Gomes Fiorott Juliana , Bertoldo Raquel , Contarello Alberta
Published: January 2023

Brazil has recently been experiencing a phenomenon of political polarization: a conflict involving political views and social identities. Considering the extent to which this socially constructed conflict has been partially fueled by the media, we propose to use the Social Representations Theory. The present study explores how discourses in the mainstream media construct the political polarization taking place in Brazil. The topics covered in 82 texts published between January 2015 and August 2019 in Brazilian mainstream press, Folha da S. Paulo and Estado de S. Paulo, were examined using content analysis and Reinert’s method with IRaMuTeQ software. A descending hierarchical analysis divided the corpus into four classes, and content analysis showed that both daily newspapers strongly criticized the political polarization underway, which was anchored to and objectified through episodes of violence, and they supported the valorization of democracy.
The home–school connection, the development of Spanish repertoires, and the school adaptation process in Latino children: a dynamic ecological understanding
Authors: Parra Velasco María Luisa
Published: January 2023

This paper aims to contribute to research and policy that supports Latino children in early education regarding their transition into the school system and their bilingual development. It presents the results of a one-year longitudinal ethnographic study of four Latino children starting school at a transitional bilingual kindergarten in the Boston area. The analysis identifies dynamics and trends at the micro and meso levels that show that Spanish use and development in Latino children cannot be fully understood and supported if we consider it an individual ability instead of an organic and intrinsic component of broader dynamic socialization, emotional, and academic processes (such as the transition to school) of which English is also a part and in which parents and teachers participate. Recommendations for designing and implementing comprehensive programs to engage Latino families and educators to support transitions, bilingual development, and academic performance in young Latino children are presented.
Reversible electrical switching of nanostructural color pixels
Authors: Zhang Shutao , Zhang Jun , Goh Wei Peng , Liu Yan , Tjiptoharsono Febiana , Lee Henry Yit Loong , Jiang Changyun , Ding Jun , Yang Joel K. W. , Dong Zhaogang
Published: January 2023

Electrical switching of nanophotonic structural color elements is a promising approach towards addressable color switching pixels for next generation reflective displays. However, electrical switching between the primary colors to colorless near-white state remains a challenge. Here, we present a reversible electrical switching approach, relying on the electrocoagulation of Ag nanoparticles between silicon nanostructures that support Mie resonances. The electrodeposited Ag nanoparticles enable the excitation of the hybrid plasmon-Mie resonance as supported on Ag-silicon nanostructures, resulting in a large spectral transformation. Importantly, this process is reversible. This device design outperforms other designs in terms of electrotonic color control since it is highly stable and reliable for use in high-resolution reflective displays, such as colored electronic papers and smart display glass, where the combination is scalable to other nanostructure designs and electrolytic solutions.
Crystal structure of 3,5,7-trimethoxy-3′,4′-methylenedioxy-flavone, C19H16O7
Authors: Tan Yong-cui , Li Ji-Xin , Ye Jiang-Hai , Zou Juan , Liu Ya-Hua
Published: January 2023

C19H16O7, monoclinic, C2/c (no. 15), a = 30.5661(14) Å, b = 7.0209(3) Å, c = 17.2028(7) Å, β = 117.342(1)°, V = 3279.3(2) Å3, Z = 8, R

gt
(F) = 0.0489, wR

ref
(F
2) = 0.1398, T = 273(2) K.
Properties and units in the clinical laboratory sciences. Part XXVII: online dynamic NPU manual (IUPAC Technical Report)
Authors: Lee Hansen Young Bae , Toska Karin , Lund Alice , Flatman Robert , Ceder Rebecca
Published: January 2023

The NPU terminology is an evolving international medical laboratory terminology that is used in health care systems. However, the literature of the terminology is assorted in at least 16 publications that are not updated. The objective is to establish an updated online manual of the NPU terminology, comprising the principles and special rules of the terminology. The manual is intended to provide easily searchable and updated information.
Dynamic properties of the attachment oscillator arising in the nanophysics
Authors: Wang Kang-Jia , Si Jing
Published: January 2023

The attachment oscillator, which plays an important role in the nanophysics such as nano/microelectromechanical systems, molecular devices, and nanofibers, is studied in this work. With the help of the semi-inverse method, the variational principle is established, and the Hamiltonian of the system is correspondingly constructed based on the obtained variational principle. Then, according to the principle of energy conservation, the energy balance theory is implemented to seek for the amplitude–frequency relationship. As predicted, the obtained solution has a good agreement with the existing results, which shows that the presented method is simple but effective, and is expected to provide a new idea for the study of the nonlinear oscillator arising in the nanophysics.
Design and performance analysis of a novel displacement-based temperature sensor
Authors: Ben Hassena Mohamed Amin , Ghommem Mehdi , Aly Abdulrahman , Hamdan Mohammad , Najar Fehmi
Published: January 2023

In this paper, we present a proof-of-concept for a novel temperature sensing approach that combines the thermal expansion and a compliant mechanism. The objective is first to demonstrate its feasibility at the macroscale, develop and validate an FEM model at the macroscale and then scale down the FEM model to verify the possible implementation of the mechanism at the microscale. The sensing approach relies on a mechanical compliant mechanism that amplifies the thermal expansion of a structure. A testing platform equipped with an IR thermometer, thermocouple, a power supply, and laser distance sensors, is implemented to demonstrate the operability of the proposed sensing mechanism. A numerical model of the sensor is developed using the FE software Ansys. The numerical results show a good agreement with their experimental counterparts at the macro scale. The model is then used to numerically investigate several configurations, namely single, double, triple and quadruple compliant mechanisms. The amplification factor is found the highest when using the double compliant mechanism. A temperature sensitivity of 28.5 μm/°C is achieved for this compliant mechanism. The numerical analysis also demonstrated that the performance obtained at the macro scale, can be conserved for microscale devices. However, buckling of some elements is observed for the microscale system which degrades the performance of the sensor when subjected to relatively large displacements. The microscale FEM model shows the possible prevention of buckling issues by slightly modifying the geometry of the compliant mechanisms. The present study is expected to provide baseline and guidance for the implementation of the sensing approach for MEMS devices.
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency
Authors: Hughes Sebastian A , Lin Meng , Weir Ashley , Huang Bing , Xiong Liya , Chua Ngee Kiat , Pang Jiyi , Santavanond Jascinta P , Tixeira Rochelle , Doerflinger Marcel , Deng Yexuan , Yu Chien‐Hsiung , Silke Natasha , Conos Stephanie A , Frank Daniel , Simpson Daniel S , Murphy James M , Lawlor Kate E , Pearson Jaclyn S , Silke John , Pellegrini Marc , Herold Marco J , Poon Ivan K H , Masters Seth L , Li Mingsong , Tang Qin , Zhang Yuxia , Rashidi Maryam , Geng Lanlan , Vince James E
Published: January 2023

Genetic lesions in X‐linked inhibitor of apoptosis (XIAP) pre‐dispose humans to cell death–associated inflammatory diseases, although the underlying mechanisms remain unclear. Here, we report that two patients with XIAP deficiency–associated inflammatory bowel disease display increased inflammatory IL‐1β maturation as well as cell death–associated caspase‐8 and Gasdermin D (GSDMD) processing in diseased tissue, which is reduced upon patient treatment. Loss of XIAP leads to caspase‐8‐driven cell death and bioactive IL‐1β release that is only abrogated by combined deletion of the apoptotic and pyroptotic cell death machinery. Namely, extrinsic apoptotic caspase‐8 promotes pyroptotic GSDMD processing that kills macrophages lacking both inflammasome and apoptosis signalling components (caspase‐1, ‐3, ‐7, ‐11 and BID), while caspase‐8 can still cause cell death in the absence of both GSDMD and GSDME when caspase‐3 and caspase‐7 are present. Neither caspase‐3 and caspase‐7‐mediated activation of the pannexin‐1 channel, or GSDMD loss, prevented NLRP3 inflammasome assembly and consequent caspase‐1 and IL‐1β maturation downstream of XIAP inhibition and caspase‐8 activation, even though the pannexin‐1 channel was required for NLRP3 triggering upon mitochondrial apoptosis. These findings uncouple the mechanisms of cell death and NLRP3 activation resulting from extrinsic and intrinsic apoptosis signalling, reveal how XIAP loss can co‐opt dual cell death programs, and uncover strategies for targeting the cell death and inflammatory pathways that result from XIAP deficiency.
Liver‐directed gene therapy for ornithine aminotransferase deficiency
Authors: Boffa Iolanda , Polishchuk Elena , De Stefano Lucia , Dell'Aquila Fabio , Nusco Edoardo , Marrocco Elena , Audano Matteo , Pedretti Silvia , Caterino Marianna , Bellezza Ilaria , Ruoppolo Margherita , Mitro Nico , Cellini Barbara , Auricchio Alberto , Brunetti‐Pierri Nicola
Published: January 2023

Gyrate atrophy of choroid and retina (GACR) is a chorioretinal degeneration caused by pathogenic variants in the gene encoding ornithine aminotransferase (OAT), an enzyme mainly expressed in liver. Affected patients have increased ornithine concentrations in blood and other body fluids and develop progressive constriction of vision fields leading to blindness. Current therapies are unsatisfactory and better treatments are highly needed. In two mouse models of OAT deficiency that recapitulates biochemical and retinal changes of GACR, we investigated the efficacy of an intravenously injected serotype 8 adeno‐associated (AAV8) vector expressing OAT under the control of a hepatocyte‐specific promoter. Following injections, OAT‐deficient mice showed reductions of ornithine concentrations in blood and eye cups compared with control mice injected with a vector expressing green fluorescent protein. AAV‐injected mice showed improved electroretinogram response and partial restoration of retinal structure up to one‐year post‐injection. In summary, hepatic OAT expression by AAV8 vector was effective at correction of hyperornithinemia and improved function and structure of the retina. In conclusion, this study provides proof‐of‐concept of efficacy of liver‐directed AAV‐mediated gene therapy of GACR.
Sustainability of Palm Oil Company CSR in Supporting Village Status Change
Authors: Septiyarini Dwi , Kusrini Novira , Kurniati Dewi
Published: January 2023

The existence of palm oil companies should have an impact on villages around oil palm companies. However, the status of villages according to the developing village index around oil palm companies are still developing villages. The purpose of this study was to determine the sustainability status of the palm oil company's CSR program in supporting changes in village status. This research was conducted in Kubu Raya Regency with 12 villages and 12 oil palm companies. This study is based on the similarity of indicators between CSR programs and the indicators of the developing village index. The data collected includes primary data and secondary data. The analysis technique uses multidimensional scaling Rapfish. The results of the study show that the sustainability status of the CSR program has the social dimension of unsustainable status with a sustainability value of 24.56, the economic dimension with a value of 57.67 with moderately sustainable status and the environment with a value of 74.27 with moderately sustainable status. The results of the 2019-2021 IDM continue to increase, but the economic resilience index has the lowest value when compared to the social and environmental resilience index.
Review of the current state and development perspectives of the solar energy in Ukraine
Authors:   Institute of General Energy of the National Academy of Sciences of Ukraine, 172 Antonovycha str., Kyiv, 03150, Ukraine, Sverdlova Anastasiia
Published: January 2023

This paper analyzes the prospects for developing solar power generation systems and the economic feasibility of further industry development. The state of global solar energy, its expansion potential, and Ukraine's position in the total statistics are examined. The rate of increase in the introduction of alternative types of energy has been determined. Statistical data on the number of commissioned power plants and the electricity they produced were analyzed. Solar energy is one of the most promising and powerful renewable energy sources. As a result of the analysis, it was concluded that Ukraine is gradually taking essential steps to expand the use of solar energy, developing a regulatory and legislative basis for the service, implementation, optimization, and stimulation of households to implement and build solar power plants. The relevance and expediency of the use of solar energy in connection with the constant growth of the cost of electricity and the future forecast of the increase of public investments in the industry at the global level are characterized. According to the analysis of statistical data and forthcoming plans for solar energy development, high rates of its growth in Ukraine have been determined. The consequences the war has on the solar energy industry are described. It is explained that, due to the war, half of the renewable energy objects are under threat of complete or partial destruction, in particular, 47% of solar power plants are located in regions where active fighting continues. The general trend of post-war development will be an increase in the share of solar energy in the overall energy balance. This will be facilitated by eliminating financial and legislative restrictions on the development of renewable energy, expanding opportunities for the export of electricity from renewable energy sources, and considering the green course, which is focused on clean energy. Keywords: alternative energy, renewable energy sources, solar power plants, electric energy
Ecopipam for Tourette Syndrome: A Randomized Trial
Authors: Gilbert Donald L. , Dubow Jordan S. , Cunniff Timothy M. , Wanaski Stephen P. , Atkinson Sarah D. , Mahableshwarkar Atul R.
Published: January 2023

BACKGROUND AND OBJECTIVES

All US Food and Drug Administration-approved medications for Tourette syndrome are antipsychotics, and their use is limited by the risk of weight gain, metabolic changes, and drug-induced movement disorders. Several small trials suggest that ecopipam, a first-in-class, selective dopamine 1 receptor antagonist, reduces tics with a low risk for these adverse events. This trial sought to further evaluate the efficacy, safety, and tolerability of ecopipam in children and adolescents with moderate to severe Tourette syndrome.

METHODS

This was a multicenter, randomized, double-blind, placebo-controlled, phase 2b trial. Subjects aged ≥6 to <18 years with a baseline Yale Global Tic Severity Score Total Tic Score of ≥20 were randomly assigned 1:1 to ecopipam (n = 76) or placebo (n = 77). The primary endpoint was mean change over 12 weeks in the Yale Global Tic Severity Score Total Tic Score. The Clinical Global Impression of Tourette Syndrome Severity was the secondary endpoint. Safety and tolerability were evaluated at each study visit.

RESULTS

Total tic scores were significantly reduced from baseline to 12 weeks in the ecopipam group compared with placebo (least squares mean differences −3.44, 95% confidence interval −6.09 to −0.79, P = .01). Improvement in Clinical Global Impression of Tourette Syndrome Severity was also greater in the ecopipam group (P = .03). More weight gain was seen in subjects assigned to placebo. No metabolic or electrocardiogram changes were identified. Headache (15.8%), insomnia (14.5%), fatigue (7.9%), and somnolence (7.9%) were the most common adverse events.

CONCLUSIONS

Among children and adolescents with TS, ecopipam reduces tics to a greater extent than placebo, without observable evidence of common antipsychotic-associated side effects.
Suicide as a form of escape from trauma? An analysis of suicidal tendencies after experiencing rape – a case study
Authors:   Instytut Psychologii, Uniwersytet Jagielloński, Kraków, Polska, Zaborowska Anna , Ruczaj Joanna ,   Instytut Psychologii, Uniwersytet Jagielloński, Kraków, Polska
Published: January 2023

The aim of this paper was to reflect on the importance of suicidal tendencies in individuals who developed symptoms of posttraumatic stress disorder after experiencing rape. We present a case report of a rape victim who attempted suicide as a result of her trauma. The experience of rape can lead to post-traumatic stress disorder and dissociative states in the victim, increasing the risk of self-destructive behaviour and suicidal ideation. Analysing the case study we considered the destructive impact of traumatogenic mechanisms and severe stress, including their short- and long-term impact on a person’s life. The results of the study highlight the importance of sensitising therapists to the symptoms of post-traumatic stress disorder and dissociative states in sexual violence survivors due to the associated risk of suicidal tendencies. Emphasising the long-term consequences of trauma should prompt the development of assistance programmes that go beyond emergency measures.
Obstruktív tüdőbetegségek súlyosbodása SARS-CoV-2-fertőzés hatására a marosvásárhelyi Pulmonológiai Klinika beteganyagában
Authors: Szathmáry Mioara , Gîrbovan Elena-Cristina , Sárközi Hédi-Katalin , Gáll Zsuzsanna , Vultur Mara Andreea , Nemeș Alexandra Floriana , Ianoși Edith Simona , Jimborean Gabriela
Published: January 2023

Bevezetés: A SARS-CoV-2-fertőzés fokozott súlyosságát mutatják a
szakirodalmi adatok szív- és érrendszeri betegségben, vesebetegségben, krónikus
obstruktív tüdőbetegségben (COPD), asztmában, elhízásban, cukorbetegségben,
daganatos betegségben szenvedő és immunszupprimált betegeknél.
Módszer: A retrospektív vizsgálatba 90 (29,7%), COPD-vel
vagy asztmás exacerbatióval összefüggő SARS-CoV-2-fertőzésben szenvedő beteget
vettünk be azon 303 betegből, akik a tanulmányozott 7 hónap alatt kórházi
felvételre kerültek. A COPD/asztma exacerbatio klinikai aspektusa átfedésben
volt a SARS-CoV-2-fertőzéssel, ezért 90, obstruktív betegség nélküli,
SARS-CoV-2-ben szenvedő beteggel hasonlítottuk össze csoportunkat. Mindkét
csoportból kizártuk azokat a betegeket, akiknek ismert súlyos
szívelégtelenségük, cukorbetegségük vagy daganatuk volt, annak érdekében, hogy
ne zavarjanak más kedvezőtlen prognosztikai tényezők. Az esetek súlyosságát
klinikai vizsgálattal, pulzoximetriával, CT/mellkasröntgen és gyulladásos
markerek alapján értékeltük. Eredmények: Mérsékelt/súlyos
tüdőgyulladásban szenvedett (kétoldali interstitialis-alveolaris beszűrődések,
emelkedett gyulladásos markerek, légzési elégtelenség) csoportunk 72,2%-a (48/52
COPD-s és 17/38 asztmás), valamint a nem obstruktív csoport 56,6%-a. 14 beteg
szorult intenzív osztályos ellátásra (beleértve a gépi lélegeztetést is). A
COPD-s csoportban 4 halálesetet regisztráltunk, az asztmás csoportban 1-et, míg
a nem obstruktív betegeknél 2-t (COPD-ben az elhalálozási ráta 7,6%, a nem
obstruktív csoportban 2,2% volt). A kezelés maximalizált inhalációs
hörgőtágítókat, oxigént, vírusellenes szereket, véralvadásgátlókat, szteroid
gyulladáscsökkentőt és tüneti kezelést tartalmazott. Az elbocsátás után 2
hónappal minden beteget klinikai, funkcionális és CT-vizsgálatra hívtunk.
Következtetés: A COPD-s vagy asztmás betegeknél gyakori
volt a SARS-CoV-2-fertőzés, ami jelentős állapotsúlyosbodáshoz vezetett.
COPD-ben nagyobb arányú volt az elhalálozás. A járóbeteg-utánkövetés célja a
kezelés újraértékelése és a COVID–19 utáni lehetséges következmények figyelemmel
kísérése. Orv Hetil. 2023; 164(2): 43–50.
Evési szokások magyar serdülők körében
Authors: Siska Dóra , Cserép Melinda , Szabó Brigitta
Published: January 2023

Bevezetés: A szakirodalom szerint az evészavarban szenvedő
serdülők körében nagyobb arányban fordulnak elő mentalizációs nehézségek és
bizonytalan érzelmi kötődési stílusok. A mentalizáció szerepét az érzelmi
kötődési mintázatok és az evési szokások közötti kapcsolatban magyar serdülők
körében még nem vizsgálták. Célkitűzés: 14 és 18 év közötti
serdülők körében a mentalizáció, az érzelmi kötődés és az evési szokások
kapcsolatának vizsgálata. Módszer: Vizsgálatunkban 143 serdülő
töltötte ki tájékozott beleegyezés után a Reflektív Funkció Kérdőívet, a
Tapasztalatok Szoros Kapcsolatokban kérdőívet, valamint az Evési Attitűdök
Tesztet. Eredmények: Az érzelmi kötődési összpontszám és a
diétázás közötti közvetlen út nem bizonyult szignifikánsnak (c’ = 0,01,
p = 0,31, β = 0,09), míg a közvetett út, az érzelmi kötődés
és az evési szokások között a mentalizációs bizonytalanságon keresztül
szignifikáns volt (∑ab = 0,01 [0,01–0,02], β = 0,07).
Megbeszélés: Eredményeink arra utalnak, hogy az érzelmi
kötődési stílusok a mentalizációs kapacitáson keresztül állnak kapcsolatban a
diétázási szokásokkal serdülők körében. Következtetés: Serdülők
körében a diétázással kapcsolatos szokások megváltoztatására mentalizációalapú
módszerek használatát javasoljuk. Orv Hetil. 2023; 164(2): 64–69.
A COVID–19-járvány hatása a leggyakoribb légzőszervi megbetegedések lefolyására
Authors: Bogos Krisztina , Berta Judit , Cselkó Zsuzsa , Tisza Judit , Szilasi Mária , Simon Beatrix , Antus Balázs , Vizi Éva , Megyesfalvi Zsolt , Döme Balázs , Rózsás Anita , Török Szilvia
Published: January 2023

Bevezetés: A SARS-CoV-2 által okozott fertőzés az elmúlt három
évben meghatározta mindennapi életünket, és nem várt terhet rótt az egészségügyi
ellátórendszerre, többek között azáltal, hogy komoly kockázati tényezőt
jelenthet a már meglévő, különböző légzőszervi megbetegedésekkel küzdő betegek
számára is. Célkitűzés: A COVID–19 és a fertőzéskor már
fennálló légzőszervi megbetegedések, elsősorban a krónikus obstruktív
tüdőbetegség (COPD), valamint az asztma összefüggéseinek feltárása.
Módszer: Hazai vizsgálatunkban közel 29 000 beteg adatait
dolgoztuk fel retrospektíven. Eredmények: Eredményeink alapján
elmondható, hogy a COPD mint társbetegség megléte a nemzetközi megállapítással
egybehangzóan összefüggést mutat a COVID–19-fertőzés súlyosságával, illetve
enyhén növeli az intenzív osztályos kezelés és a gépi lélegeztetés
szükségességének kockázatát a SARS-CoV-2 okozta megbetegedés során. Asztma
esetében mindezt nem sikerült kimutatnunk, vagyis sem a SARS-CoV-2-fertőzés
súlyosságát, sem az intenzív osztályos kezelés és a gépi lélegeztetés
szükségességét nem befolyásolta jelentősen az asztma mint társbetegség megléte.
Megbeszélés: Ahogy nemzetközi tanulmányokban is olvasható,
a COPD mint társbetegség megléte nem növeli jelentős mértékben a
SARS-CoV-2-fertőzés kockázatát. Ugyanakkor kijelenthető, hogy a COPD növeli a
COVID–19-pozitív betegek kórházba kerülésének esélyét, és emeli a megbetegedés
súlyosabb lefolyásának valószínűségét. Tekintettel a COPD-betegekben a tüdő
károsodása során végbemenő szerkezeti átépülésre és rendellenes regenerálódási
folyamatokra, e betegek a vírusfertőzés lezajlása után fokozott odafigyelést,
valamint személyre szabott rehabilitációt igényelnek.
Következtetés: Összességében elmondható, hogy a jövőben a
személyre szabott terápiás megközelítés bevezetéséhez elengedhetetlen a
különböző COPD-s fenotípusok (valamint egyéb krónikus tüdőbetegségek) és a
SARS-CoV-2-fertőzés klinikai megnyilvánulásainak mélyreható vizsgálata. Orv
Hetil. 2023; 164(2): 51–56.
Nőgyógyászati daganatok esetén jelentkező szinkrón tumorok együlésben való ellátása három eset kapcsán
Authors: Kremzer Tamás , Pete Imre , Ruttner Pál , Csucska Máté , Lóderer Zoltán
Published: January 2023

A daganatos betegek kivizsgálása során a második tumor előfordulási esélye 15,2%,
a harmadik tumoré 1,3%. A közlemény célja felhívni a figyelmet arra, hogy a
szinkrón tumorok együlésben történő sebészi ellátása megfelelő szakmai háttérrel
a betegek számára kifejezett előnyökkel jár. Az irodalomban nem találhatók
protokollok a többes tumorok ellátására, többségében esetismertetések állnak
rendelkezésre iránymutatásul. A dolgozatban részletezésre kerül a betegségek
preoperatív stádiuma, a kivizsgálási protokoll, a műtét, valamint a szövettani
eredmény. A közlemény bemutatja egy hármas tumor – szeméremtest-, rectum-,
sigmatumor –, egy nagy kiterjedésű colontumor és endometrium-adenocarcinoma
ellátását nyitott műtét során, valamint egy neoadjuváns kezelésen átesett
betegnél rectum- és szinkrón endometrium-adenocarcinoma minimálinvazív műtétjét.
A bemutatott három eset is bizonyítja, hogy a betegeknek kifejezetten előnyös az
együlésben való műtéti megoldás, nem beszélve a költséghatékonyságról. A
közleménynek nem témája a műtét utáni vagy adjuváns kezelés megvitatása, ennek
eldöntése egyéni elbírálás alapján a kórházak multidiszciplináris
szakbizottságainak feladata. Orv Hetil. 2023; 164(2): 70–75.
Special abilities and qualities of young fencers aged 10-12 as criteria for success in sports
Authors: Klymenchenko Victoriya , Kryventsova Iryna , Chamera Michał
Published: January 2023

Background and purpose. The success of young athletes depends on many personality characteristics and elements of the training system. The purpose of the study is to identify the most significant special abilities and qualities of young fencers aged 10-12 years old at the initial stage of training.

Material and methods. Leading coaches and qualified fencers of sports clubs participated in the study (n=21). The participants were selected according to their rating among Ukrainian specialists, most of whom are representatives of fencing clubs in Kharkiv (Ukraine). A questionnaire containing questions about the main elements of general training of young fencers was used.

Results. The main indicators of a fencer's general readiness are: intellectual development (knowledge, skills, abilities); physical development (anthropometric data and psychosomatics); physical qualities; technical readiness; tactical preparedness (understanding, ability, skills). The levels of significance of the specified indicators of the young fencer's personality have been established. The most important indicators are: intellectual skills (95.23%) and skills (90.47%); development of dexterity (61.90%) and speed (42.85%); the fencer's understanding of the purpose of performing technical techniques (71.42%).

Conclusions. At the initial stages of training young fencers, it is recommended to pay attention to the special abilities and qualities of young fencers. This approach makes it possible to promote the success of young fencers in sports.
Increasing the level of coordination abilities of young taekwondo athletes aged 13-14 under martial law
Authors: Lyuchkova Elizaveta , Nesen Olena , Bartik Pavol , Skrobecki Jerzy
Published: January 2023

Background and Study Aim. Negative changes in the socio-economic environment in the territory of martial law (Ukraine) have a great impact on the ability to continue the training process for athletes. To a lesser extent, this affects experienced world-class athletes who have the opportunity to continue training in other countries. As for young athletes, they are closely connected with their family. This fact reduces the possibility of their preparation. The purpose of the work is to develop the coordination abilities of taekwondo fighters aged 13-14 under martial law

Material and methods. The study involved young taekwondo players from Ukraine (n=8, age - 13-14 years old), compactly living in the same area. A survey was conducted among experienced trainers (n=10), who had the opportunity to answer the questionnaire through electronic means of communication ( similar to the Likert scale.) Parents gave their consent to the participation of their children in the experiment. Participants were given homework in the form of exercises to develop the ability to maintain balance. The participants performed the Romberg test on the left and right leg with visual control, without control and Yarotsky's test. Participants conducted tests during a specially organized ZOOM video conference. This study was conducted by the Declaration of Helsinki and was approved by the Ethics Committee of University. All participants were aware during the informed consent process that the results of this study may be published.

Results. According to the coaches, the most important qualities for taekwondo athletes are speed and coordination. Among the coordination abilities trainers note as the most important the following: the sense of rhythm, the sense of time and distance, balance and vestibular stamina. Equilibrium indicators on an unstable support (Romberg test) have undergone significant positive changes (at p˂0.05). Although the Yarotsky test indicators had positive improvements, they did not have significant differences (at p˃0.05).

Conclusions. When declaring martial law, it is recommended to pay special attention to the life safety of participants in the education and training process. It is also recommended to use exercises on an unstable support, which are in the nature of imitation percussion and protective actions. This approach leads to a tangible improvement in the balance of young athletes.
Pragmatics: A Slim Guide Betty J. Birner (2021)
Authors: Ye lin lin , He Shi jin , Luo Hong li
Published: January 2023

Pragmatics: A Slim Guide Betty J. Birner (2021) Oxford University Press
Kingship and Covenant: Reconsidering the Oath of David and Jonathan
Authors: Johnson Sophia R. C.
Published: January 2023

Frank Moore Cross’s model of covenant as an early legal means of extending fictive kinship has dominated Anglo-American biblical scholarship for the last thirty years. His central case study is the covenant between David and Jonathan and the associated oath sworn by Jonathan in 1 Sam 20. In trying to distill a simple covenant concept, however, Cross collapses distinctions of genre and context, reducing the significance of secular covenant as a form of political bond to simply merging kinship groups. In this article, I reanalyze the oath in 1 Sam 20:12–17, contextualizing it with other material throughout 1 and 2 Samuel and comparing it to ancient Near Eastern treaty formulations to show its political significance in Israelite history. In contrast to Cross’s notion of imposing kinship obligations, the oath addresses questions of succession and dynasty, anticipating the political turmoil of David’s ascension to the throne. Deuteronomistic language and concern with Davidic succession shared between the oath and the divine promise in 2 Sam 7 point to a common vision of a united kingship. Far from the reiteration of a simple kinship bond, Jonathan’s oath of loyalty to their covenant becomes a keystone in the Deuteronomistic ideal of an eternal Davidic dynasty.