Investigation of biological compatibility of polytetrafluoroethylene grade PN-90 on experimental animals
Authors:   chief engineer of the Educational, Scientific and Technological Laboratory "Technologies of Polymer Nanocomposites", Institute of Natural Sciences, Sidorova D.N. ,   Research Engineer, Laboratory of Medical Biotechnologies, Medical Institute, NEFU, Spiridonov A.M. ,   Candidate of Chemical Sciences, Leading Researcher, Head of the Laboratory Polymer composites for the North, Institute of Natural Sciences, NEFU, Troev I.P. ,   Senior Researcher, Laboratory of Medical Biotechnologies, Medical Institute, NEFU, Marinova L.G. ,   Candidate of Medical Sciences, Researcher, Laboratory of Medical Biotechnologies, Medical Institute, NEFU, Kirillina M.P. ,   Yakut Science Centre of Complex Medical Problems (YSC CMP), Yakutsk, Ru, Palshin G.A. ,   Doctor of the Medical Sciences, Professor, Head of the Department of Traumatology, Orthopedics and Disaster Medicine, Medical Institute, NEFU, Sivtsev D.V. ,   Student of the Chemical Department of the Institute of Natural Sciences, NEFU, Dyakonov A.A. ,   Candidate of Technical Sciences, Senior Researcher of the Educational, Scientific and Technological Laboratory Technologies of Polymer Nanocomposites, Institute of Natural Sciences, NEFU, Lazareva N.N. ,   Candidate of Technical Sciences, Leading Researcher - Head of the laboratory of the Educational, Scientific and Technological Laboratory "Technologies of Polymer Nanocomposites", Institute of Natural Sciences, NEFU, Okhlopkova A.A. ,   Doctor of Technical Sciences, Professor of the Chemical Department, Chief Researcher of the Educational, Scientific and Technological Laboratory "Technologies of Polymer Nanocomposites", Institute of Natural Sciences, NEFU
Published: January 2025

Polymer products are widely used in the field of medicine in the form of implants, artificial vessels, heart valves, etc. However, the tasks of searching, developing and studying the properties of polymeric materials for medical purposes remain relevant. This paper presents the results of biocompatibility research of PN-90 polytetrafluoroethylene implanted in the subcutaneous fat space of laboratory animals (Wistar rats). The implantation of the polymer was carried out under general anesthesia in the subscapular area. Histological sections of tissues from the control area and adjacent to the implant were studied. Around the implanted polytetrafluoroethylene there was is an intensive growth of new vessels of various calibers combined with severe fibroblasts proliferation. The polymeric material was also investigated by means of an IR spectrometer and a scanning electron before and after implantation. According to the results of IR spectroscopy the chemical composition of the polymer remained unchanged. The surface of polytetrafluoroethylene after implantation was practically identical to the surface of the initial polymer. Based on the data obtained, it can be concluded that polytetrafluoroethylene is biologically compatible and can be used in medicine as a base for implants.
Keywords: biocompatibility, inflammation, wear resistance, implantation, polytetrafluoroethylene, rats.