bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical Stress Modulates the RANKL/OPG System of Periodontal Ligament Stem Cells via α7 nAChR in Human Deciduous Teeth: An In Vitro Study
Authors: Chen Yujiang , Yang Kuan , Zhou Zhifei , Wang Lulu , Du Yang , Wang Xiaojing
Published: May 2019

The aim of this study was to investigate the mechanism by which periodontal ligament stem cells (PDLSCs) modulate root resorption of human deciduous teeth under mechanical stress. In this investigation, the PDLSCs were derived from deciduous and permanent teeth at different stages of root resorption. A cyclic hydraulic pressure was applied on the PDLSCs to mimic chewing forces in the oral environment. The cultured cells were characterized using osteogenic and adipogenic differentiation assays, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting analysis. The PDLSCs exhibited the ability to induce osteoclast differentiation under certain mechanical stresses. As the expressions of RUNX2, alkaline phosphatase (ALP), and osteoprotegerin (OPG) were significantly reduced, the receptor activator of the nuclear factor kappa-B ligand (RANKL) was upregulated increasing the RANKL/OPG ratio. Under hydrodynamic pressure at 0-135 kPa, the expressions of alpha 7 nicotinic acetylcholine receptors (α7 nAChR), p-GSK-3β, and active-β-catenin were markedly upregulated in PDLSCs from unresorbed deciduous teeth. Treatment with the α7 nAChR inhibitor alpha-bungarotoxin (α-BTX) and the Wnt pathway inhibitor DKK1 may reverse the mechanical stress inducing upregulation of RANKL and reduction of RUNX2, ALP, and OPG. Alizarin red staining confirmed these results. The mechanical stress applied on the deciduous tooth PDLSCs can induce osteoclastic effects through upregulation of α7 nAChR and activation of the canonical Wnt pathway. It can be suggested that chewing forces may play a major role at the beginning of the physiological root resorption of deciduous teeth.
Construction and Evaluation of a Subcutaneous Splenic Injection Port for Serial Intraportal Vein Cell Delivery in Murine Disease Models
Authors: Miki Toshio , Takano Chika , Garcia Irving M. , Grubbs Brendan H.
Published: May 2019

The liver is the largest internal organ and the center of homeostatic metabolism. Liver-directed cell transplantation is, therefore, an attractive therapeutic option to treat various metabolic disorders as well as liver diseases. Although clinical liver-directed cell transplantation requires multiple cell injections into the portal venous system, a mouse model is lacking which allows us to perform repetitive cell injections into the portal venous system. Here, we propose a surgical model that utilizes the spleen as a subcutaneous injection port. Mouse spleens were translocated under the skin with intact vascular pedicles. Human placental stem cell transplantations were performed one week following this port construction and repeated three times. Cell distribution was analyzed by quantifying human DNA using human Alu-specific primers. About 50% of the transplanted cells were located homogeneously in the liver one hour after the splenic port injection. Fluorescent-labeled cell tracking and antihuman mitochondrion immunohistochemistry studies demonstrated that the cells localized predominantly in small distal portal branches. A similar cell distribution was observed after multiple cell injections. These data confirm that the subcutaneous splenic injection port is suitable for performing repetitive cell transplantation into the portal venous system of mouse models.
Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage
Authors: Song Myung Jin , Lim Sung Yoon , Park Jong Sun , Yoon Ho il , Lee Jae-Ho , Kim Song Yee , Jung Ji Ye , Kang Young Ae , Park Moo Suk , Kim Young Sam , Chang Joon , Lee Sang Hoon , Lee Choon-Taek
Published: May 2019

Introduction. Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer development, and small cell lung cancer (SCLC) comprises 15-20% of lung cancers with IPF. The objective of this study was to investigate survival outcomes and treatment-related complications according to GAP (gender, age, and physiology) stage in patients having SCLC with IPF (SCLC-IPF). Materials and Methods. Retrospectively collected data of SCLC-IPF patients from two tertiary care university hospitals in South Korea were reviewed. A total of 59 SCLC-IPF patients were identified and categorized according to GAP stage, which was proposed by Ley et al. in 2012 to predict the prognosis of IPF. Survival outcomes and treatment-related complications were compared between the two groups. Results. In a total of 59 patients, the median age was 71 years and 58 (98.3%) were male. In a comparison of the median overall survival (OS) according to GAP stage, median OS of the advanced GAP stage group was significantly shorter than median OS of GAP stage I group (7.1 months vs. 16.1 months; p = 0.002). Treatment-related complications occurred more frequently in the advanced GAP stage group; advanced GAP stage was the only predictor that exhibited a significant association with the incidence of acute exacerbation of IPF. Conclusions. Inferior survival outcome and higher incidence of treatment-related pulmonary toxicities were noted in the advanced GAP stage group. Furthermore, advanced GAP stage was the only predictor of treatment-related acute exacerbation of IPF. Physicians should thus consider GAP stage, which reflects the severity of IPF, during treatment of SCLC-IPF.
The Mitla Landslide, an Event That Changed the Fate of a Mixteco/Zapoteco Civilization in Mesoamerica
Authors: Garduño-Monroy V. H. , Figueroa-Soto A. , Magaña-García N. , Ruiz-Figueroa A. , Gómez-Cortés J. , Jiménez-Haro A. , Hernández-Madrigal V. M.
Published: May 2019

Before the arrival of the Spanish conquerors, Mitla was the second most important city in the valleys of Oaxaca, México. However, the ruins that are visible today do not seem to match the size of a city of more than 10,000 inhabitants. Geological and geophysical studies suggest that part of the city was covered by the deposits of a dry landslide likely to have been caused by an earthquake with a magnitude that could vary between 6 and 7. This landslide is monolithological, which is why two geophysical methods were used in order to evaluate its geometrical characteristics and to suggest the possible existence of archeological remains under the landslide.
Dynamics Modeling and Analysis of SIS Epidemic Spreading in Cluster Networks
Authors: Tian Jingjing , Li Shuping
Published: May 2019

In this paper, we propose and study an SIS epidemic model with clustering characteristics based on networks. Using the method of the existence of positive equilibrium point, we obtain the formula of the basic reproduction number R0. Furthermore, by constructing Lyapunov function, we also prove that the disease-free equilibrium of the model is globally asymptotically stable when R0<1. When R0>1, there is only one positive equilibrium point which is globally asymptotically stable. It is also shown that the infection proportion and the basic reproduction number R0 increases as the clustering coefficient increases when the average degree of networks is fixed.
The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway
Authors: Aquila Giorgio , Marracino Luisa , Martino Valeria , Calabria Donato , Campo Gianluca , Caliceti Cristiana , Rizzo Paola
Published: May 2019

Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have been shown to be involved in the processes underlying atherosclerosis, and evidence has been accumulating for the crucial role of Notch receptors in regulating the functions of the diverse cell types involved in atherosclerosis onset and progression. Several classes of nutraceuticals have potential benefits for the prevention and treatment of atherosclerosis and CVDs, some of which could in part be due to their ability to modulate the Notch pathway. In this review, we summarize the current state of knowledge on the role of Notch in vascular health and its modulation by nutraceuticals for the prevention of atherosclerosis and/or treatment of related CVDs.
Osseous Sarcoma: Is Sarcoma the New Emperor of Maladies? Case-Series with Brief Review of the Literature
Authors: Sharma Dikshya , Narula Naureen , Mudduluru Bindu , Joseph Bino , Elsayegh Dany
Published: May 2019

Sarcoidosis is multisystem disease that has been amusing physicians since its discovery in 1989 by Caesar Boeck. More than 10,000 articles have been published in the literature by far, and each time it affects a new organ. Involvement of bone has been recently discovered and because it is still a rare entity, it is important to focus on the presenting systems and also to be able to differentiate it from other closely related diseases including but not limited to tumor and other infectious processes. We describe two cases of osseous sarcoma in two relatively young but surprisingly asymptomatic patients.
Liver Transplantation from Voluntary Organ Donor System in China: A Comparison between DBD and DCD Liver Transplants
Authors: Chen Wei , Yadav Dipesh Kumar , Bai Xueli , Lou Jianying , Que Risheng , Gao Shunliang , Li Guogang , Ma Tao , Wang Ji , Huang Bingfeng , Liang Tingbo
Published: May 2019

Background. In China, the cases of liver transplantation (LT) from donation after citizens’ death have rose year by year since the citizen-based voluntary organ donor system was initiated in 2010. The objective of our research was to investigate the early postoperative and late long-term outcomes of LT from donation after brain death (DBD) and donation after circulatory death (DCD) according to the current organ donation system in China. Methods. Sixty-two consecutive cases of LT from donation after citizens’ death performed in our hospital between February 2012 and June 2017 were examined retrospectively for short- and long-term outcomes. These included 35 DCD LT and 27 DBD LT. Result. Subsequent median follow-up time of 19 months and 1- and 3-year graft survival rates were comparative between the DBD group and the DCD group (81.5% and 66.7% versus 67.1% and 59.7%; P=0.550), as were patient survival rates (85.2% and 68.7% versus 72.2% and 63.9%; P=0.358). The duration of ICU stay of recipients was significantly shorter in the DBD group, in comparison with that of the DCD group (1 versus 3 days, P=0.001). Severe complication incidence (≥grade III) after transplantation was identical among the DBD and DCD groups (48.1% versus 60%, P=0.352). There was no significant difference in postoperative mortality between the DBD and DCD groups (3 of 27 cases versus 5 of 35 cases). Twenty-one grafts (33.8%) were lost and 18 recipients (29.0%) were dead till the time of follow-up. Malignancy recurrence was the most prevalent reason for patient death (38.8%). There was no significant difference in incidence of biliary stenosis between the DBD and DCD groups (5 of 27 cases versus 6 of 35 cases, P=0.846). Conclusion. Although the sample size was small to some extent, this single-center study first reported that LT from DCD donors showed similar short- and long-term outcomes with DBD donors and justified the widespread implementation of voluntary citizen-based deceased organ donation in China. However, the results should be verified with a multicenter larger study.
Concise Robust Control of Marine Engine Speed Based on Backstepping and Its Fuzzy Comprehension
Authors: Wang Lijun , Wang Sisi
Published: May 2019

In this paper, a concise robust control law based on Backstepping for marine engine speed regulation is presented with the uniform asymptotic stability of the closed‐loop system proved by Lyapunov synthesis, and the control parameters have obvious physical meaning. Furthermore, parameter determination method is given by virtue of closed‐loop gain shaping algorithm. To overcome the perturbation due to load or interference change, variable universe fuzzy inference is introduced to optimize the control system on‐line. Compared with the existing research literature, the design method and performance of the controller are more in line with the ocean engineering practice. The results of the simulations of the proposed controller are presented and compared.
Perspectives for Clinical Translation of Adipose Stromal/Stem Cells
Authors: Patrikoski Mimmi , Mannerström Bettina , Miettinen Susanna
Published: May 2019

Adipose stromal/stem cells (ASCs) are an ideal cell type for regenerative medicine applications, as they can easily be harvested from adipose tissue in large quantities. ASCs have excellent proliferation, differentiation, and immunoregulatory capacities that have been demonstrated in numerous studies. Great interest and investment have been placed in efforts to exploit the allogeneic use and immunomodulatory and anti-inflammatory effects of ASCs. However, bridging the gap betweenin vitroandin vivostudies and moving into clinical practice remain a challenge. For the clinical translation of ASCs, several issues must be considered, including how to characterise such a heterogenic cell population and how to ensure their safety and efficacy. This review explores the different phases ofin vitroand preclinical ASC characterisation and describes the development of appropriate potency assays. In addition, good manufacturing practice requirements are discussed, and cell-based medicinal products holding marketing authorisation in the European Union are reviewed. Moreover, the current status of clinical trials applying ASCs and the patent landscape in the field of ASC research are presented. Overall, this review highlights the applicability of ASCs for clinical cell therapies and discusses their potential.
Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB
Authors: Zhong Hairong , Hong Choyoung , Han Zhouxin , Hwang Seung Jin , Kim Byunghyun , Xu Zihang , Lee Junmun , Hoon Kim Ki , Jin Mu Hyun , Zou Chunpu
Published: May 2019

In oriental medicine, mixtures of medical plants are always used as prescriptions for diseases. Natural products extracted from herbs have great potential antiaging effects. Previous studies and clinical trials have shown several critical functions of Erjingwan (EJW), such as nourishing Yin, kidney tonifying and aging-resistance. We assumed that EJW extracts exerted the antiaging effects through nourishing Yin. We examined the antiaging effects of EJW extracts on healthy human skin by noninvasive measurements. Then we estimated the cell proliferation and DPPH radical scavenging rate. Western blotting analysis was used to determine the expressions of matrix metalloproteinase-1 (MMP-1), type I collagen (COL1A2), p-NF-κB, NF-κB, p-IκBα, IκBα, p-Nrf2, and HO-1. EJW extracts did not affect moisture content, TEWL and skin chroma, while it significantly improved skin glossiness and skin elasticity. Moreover, EJW extracts could downregulate the MMP1 expression and upregulate the COL1A2 expression. In addition, it promoted the Nrf2 pathway while it inhibited the NF-κB pathway. With the application of cream containing EJW extracts, the skin aging state was significantly improved. Furthermore, in vitro studies showed that EJW extracts contributed to the repair of skin after injury. Taken together, the antiaging effects of EJW extracts were related to its antioxidant and anti-inflammatory abilities.
Intramuscular Hemangioma of the Forearm with Flexion Contracture
Authors: Niempoog Sunyarn , Pholsawatchai Waroot
Published: May 2019

Intramuscular hemangiomas can be an infrequent but important cause of musculoskeletal pain. This report describes a 25-year-old male who presented with pain in the right forearm and contracture of the right hand for 4 years. Physical examination revealed severe tenderness of the midforearm with contracture of the flexor tendons in the index, middle, ring, and little fingers. Conventional radiography of the forearm revealed a soft tissue phlebolith. Magnetic resonance imaging showed a well-defined lobulated mass partially involving the FDP tendon. An intramuscular hemangioma within the deep anterior compartment of the forearm was suspected. Following surgical excision of the hemangioma, the patient’s symptoms resolved completely. In conclusion, intramuscular hemangioma can be a rare cause of flexion contracture of the hands and should be considered as a cause of a flexion contracture that fails to respond to conservative treatment.
The Trimming-Based Design Method for PWR Coolant Flow Distribution Device
Authors: Hui Qian , Li Wenqiang , Li Yan , Wang Zhonghui , Li Hao , Guo Xin
Published: May 2019

In order to resolve the situations of nonuniform coolant flow distribution and insufficient vortex suppression, the existing Pressurized Water Reactor (PWR) usually adopts complex coolant mixing structures. However, those structures will greatly increase the complexity and maintenance cost of the system. To solve this problem, a trimming-based design method is proposed in this paper for the complex system and applies it to the design process of the PWR coolant flow distribution device. The function model of the coolant flow distribution system is built based on its functional analysis, and, according to the result of the component feature analysis, the columns and part of the basket are trimmed in order to simplify the overall structure of the system. To further solve the technical contradictions occurred in the simplified system, the contradiction solving tools of TRIZ theory are adopted. By setting the stereo flow equalizing plate, which can strengthen the function of flow distribution and vortex suppression, a coolant flow distribution device for PWR based on dome structure is obtained finally. This device owns a simple structure with good effect on coolant flow distribution and vortex suppression, which can achieve the goal of uniform coolant flow distribution of the system effectively.
Circulating MicroRNA-499 as a Diagnostic Biomarker for Acute Myocardial Infarction: A Meta-analysis
Authors: Zhao Jingyi , Yu Hairong , Yan Peng , Zhou Xiaohui , Wang Ying , Yao Yinhui
Published: May 2019

Background. Recent studies have shown that circulating microRNA-499 could be a powerful biomarker of acute myocardial infarction (AMI). Interest in circulating microRNA-499 for detecting AMI is increasing rapidly. To evaluate the diagnosis of circulating microRNA-499 for AMI, this study was performed. Methods. We searched PubMed, Embase, and the Cochrane Library for studies published up to December 31, 2018, as well as the reference lists of relevant studies. Studies were included if they assessed the accuracy of blood circulating microRNA-499 or cardiac troponin T (cTnT) for AMI and provided sufficient data to construct a 2×2 contingency table. Extracted data were analysed for sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operator curve (SROC) analyses. Prespecified subgroup analysis and metaregression were also performed. Results. Fourteen studies including 3816 participants were included in this meta-analysis. The overall pooled sensitivity and specificity were 0.84 (95% CI: 0.64-0.94) and 0.97 (95% CI: 0.90-0.99), respectively. The area under the SROC curve (AUC) was 0.98 (95% CI: 0.96-0.99). The studies had substantial heterogeneity (I2=98.74%). Seven studies also used cTnT as a marker for the diagnosis of AMI. The overall pooled sensitivity and specificity of cTnT were 0.95 (95% CI: 0.87-0.98) and 0.96 (95% CI: 0.85-0.99), respectively. The area under the SROC curve (AUC) was 0.99 (95% CI: 0.97-0.99). The DOR of circulating miR-499 and cTnT were 188 (95% CI: 19-1815) and 420 (95% CI: 86-2038), respectively. Metaregression analysis suggested that specimen and healthy controls were the main sources of heterogeneity. No publication bias was suggested by Deeks’ regression test of asymmetrical funnel plot (t=0.85; p value = 0.41). Conclusion. The results showed that circulating microRNA-499 is a reliable biomarker for diagnosing AMI patients.
Utilization of Synthesized Zeolite for Improved Properties of Pyrolytic Oil Derived from Used Tire
Authors: Osayi Julius I. , Osifo Peter
Published: May 2019

This paper reports the investigation of zeolite NaY synthesized from kaolin, a locally abundant soil material found in the Benin City metropolis, Nigeria, as a suitable catalyst and its effect on the properties of pyrolytic oil produced from used tires. The pyrolysis process was conducted from a range of 1 to 10 wt.% of catalyst concentration to the used tire at an operating temperature of 600°C, heating rate of 15°C/min, and particle size of 6 mm. An increase in the catalyst weight gave a maximum yield of catalytic pyrolytic oil (CPO) of 21.3 wt.% at a catalyst-to-tire ratio of 7.5 wt.%. Although this was lower than the noncatalyzed pyrolytic oil yield (34.40 wt.%), the quality in terms of chemical composition and hydrocarbon fuel range varied from that of the noncatalyzed pyrolytic oil, as indicated by the FT-IR, NMR, and GC-MS analyses. From the GC-MS result, the CPO gave a benzene yield higher than that of noncatalyzed pyrolytic oil. The CPO benzene yield can be ranked as CPO (5 wt.%) > CPO (1 wt.%) > CPO (10 wt.%) > CPO (7.5 wt.%) > noncatalyzed pyrolytic oil. The catalyst also improved the yield of other valuable chemicals such as ethylbenzene, o- and p-xylene, styrene, toluene, quinoline, pyrene, thiophene, P-cresol, phenol, and limonene in the pyrolytic oil. For hydrocarbon range, the catalyst displayed the potential to increase the yield of carbon range (C6–C15), which is similar to gasoline (C6–C12) and kerosene (C11–C14), with a lower yield of diesel and fuel oils (C11–C20) when compared to the noncatalyzed pyrolytic oil.
Research on the Development Mechanism of Postpeak Cracks in Sandstone under Different Confining Pressures
Authors: Zhang Jihua , Wang Lianguo , Dong Yun , Chen Yadong , Jiang Yang , Sun Huasheng , Chen Jiarui , Fan Yuqing
Published: May 2019

Water inrush happens occasionally during deeper roadways excavation. It is mainly due to the lack of understanding in the formation and development mechanism of cracks and its spatial distribution pattern under ground stress. In view of this, this paper used different stress levels to represent the fracture state of different parts of the surrounding rock of the deep roadway; CT detection technique is used to scan the fractured sandstone in the postpeak state; and the CT images under different confining pressures are thus obtained. The geometrical parameters such as area, length, and width of the crack are used to describe the distribution patterns based on CT images processing technique and statistical principle. These patterns are then analyzed under varying postpeak stress levels and confining pressures. The result shows that, as the area, length, and width of the cracks get larger, number of cracks increases with decreasing stress level; at different stress levels, sandstone crack area probability density, crack length probability density, and crack width probability density form exceptional, linear, and Gaussian distribution, respectively. The amount of confining pressure affects the size of cracks and the extent of expansion. This means that the higher the confining pressure is, the easier the internal crack will be penetrated and expanded and the bigger the cracks are, and the number of cracks gets lesser. Such research results can be used to describe the propagation and evolution law of cracks under different stress states of postpeak rock, which also provide an important basis for further analysis of its permeability and the stability of roadway surrounding rock.
Pattern Synthesis of Time-Modulated Array Antenna Based on an Improved Invasive Weed Optimization Method
Authors: Zhang Zhenkai , Liu Xinxing , Zhang Bing , Li Hailin
Published: May 2019

In this paper, pattern synthesis through time-modulated linear array is studied, and a novel strategy for harmonic beamforming in time-modulated array is proposed. The peak side lobe level is designed as optimization objective function, and the switch-on time sequence of each element is selected as optimization variable. An improved invasive weed optimization (IWO) algorithm is developed in order to determine the optimal parameters describing the pulse sequence used to modulate the excitation weights of array elements. Representative results are reported and discussed to point out potentialities and advantages of the proposed approach, which can obtain lower objective function values.
Investigation of Pressure Rise and Flame Acceleration Characteristics in a Single Channel of Wave Rotor Combustor with Spoilers
Authors: Li Jianzhong , Zhang Kaichen , Li Wei , Yuan Li
Published: May 2019

A simplified single channel wave rotor combustor (WRC) experimental rig was established, in which the spoilers with different blockage ratios (BR) could be conveniently installed and disassembled. The spoilers were firstly used for WRC to improve the pressure rise. The effects of different blockage ratios on the pressure rise and flame acceleration characteristics in a single channel of the WRC were investigated. The addition of spoilers could remarkably improve the pressure rise and flame propagation speed in a single channel of the WRC. While the blockage ratio of the spoiler increases, both pressure rise and mean flame propagation speed are improved. When the spoilers with a blockage ratio of 38.91% are used, the peak pressure increases by 200% compared to that of WRC without the spoilers. When the spoilers of different blockage ratios (23.35%, 31.13%, and 38.91%) are used, it is found that the flame propagation speed is significantly improved with the increasing of the blockage ratio. Specifically, the maximum flame propagation speed reaches 55 m/s, and the maximum mean flame propagation speed is 36.95 m/s. Furthermore, combustion becomes more intense, and the flame is brighter around the spoiler.
Miniaturization of a Microstrip Patch Antenna with a Koch Fractal Contour Using a Social Spider Algorithm to Optimize Shorting Post Position and Inset Feeding
Authors: Souza Eduardo A. M. , Oliveira Phelipe S. , D’Assunção Adaildo G. , Mendonça Laércio M. , Peixeiro Custódio
Published: May 2019

This paper presents a social spider optimization (SSO) design of a small-size microstrip antenna. Two antenna miniaturization techniques, based on the use of a Koch fractal contour and a shorting post (connecting the patch to the ground plane), are combined to enable a major size reduction. The antenna is inset fed by a microstrip line. The developed SSO algorithm is used to find out the best radius and position of the shorting post and the length of the inset feed, to achieve the desired resonant frequency with good impedance matching. Antenna prototypes have been fabricated and measured. The good agreement obtained between numerical simulation and experimental results has validated the design procedure. Compared with a conventional rectangular patch, the antenna resonance frequency is reduced from 2.45 GHz to 730 MHz, which corresponds to a remarkable miniaturization of about 70%. The proposed antenna is suitable for applications in the 700-800 MHz frequency range, such as 4G mobile communication systems.
Fractional‐Order Accumulative Linear Time‐Varying Parameters Discrete Grey Forecasting Model
Authors: Gao Pumei , Zhan Jun , Liu Jiefang
Published: May 2019

Traditional discrete grey forecasting model can effectively predict the development trend of the stabilizing system. However, when the system has disturbance information, the prediction result will have larger error, and there will appear significant downward trend in the stability of the model. In the presence of disturbance information, this paper presents a fractional‐order linear time‐varying parameters discrete grey forecasting model to deal with the system that contains both linear trend and nonlinear trend. The modeling process of the model and calculation method are given. The perturbation bounds of the new model are analyzed by using the least‐squares method of perturbation theory. And it is compared with that of the first‐order linear time‐varying parameters discrete grey forecasting model. Finally, two real cases are given to verify the effectiveness and practicality of the proposed method.
Level and Correlates of Unmet Need of Contraception among Women in Extended Postpartum in Northern Ethiopia
Authors: Embafrash Gurja , Mekonnen Wubegzier
Published: May 2019

Background. About 222 million women in developing countries had unmet need for contraception. Women in their first year after childbirth had the largest proportion of unmet need for contraception. This first year after delivery is described as an extended postpartum period. Objective. To determine the level and correlates of unmet need for family planning among women who are in an extended postpartum period in the Tahtay Koraro District, Northern Ethiopia. Material and Method. A cross-sectional facility-based study complemented by in-depth interview of key informant was implemented. A total of 409 women in the 1st year after delivery were recruited. The study period was from 1st February to March 30, 2014. For quantitative data Epi-Info version 3.5.4 software was used for data entry, and then data were exported to SPSS Version 21 software for further analysis. Logistic regression model was used to identify factors associated with the outcome variable. The transcribed and translated qualitative text data were imported into an Open Code program and coded. Then codes were categorized and thematically described. Results. The overall unmet need for family planning was 150 (36.7%), with 121 (29.6%) for spacing and 29 (7.1%) for limiting. One hundred twenty (29.3%) women were using family planning and 94 (78.3%) of them were using injectable. The commonest reasons for nonuse of FP were nonmenstruating since last birth 201 (69.6%), side effects 39 (13.5%), and not having sex 25 (8.7%). Rural residence (AOR=7.16, 95% CI 2.57-19.95), postpartum week (26-38 weeks; AOR=8.16, 95% CI 4.24-15.71), and low perceived risk of pregnancy (AOR=1.79, 95% CI 1.04-3.09) were significantly associated with high unmet need. Opposition from different groups of the community, low perceived risk of pregnancy, provider refusal of removal of implants, and misunderstanding of FP use and side effects were additional triggering factors for unmet need. Conclusion and Recommendation. The unmet need for family planning was high. Rural residence, increased maternal postpartum week, and low perceived risk of pregnancy were associated with high unmet need. Opposition from different sects of the community and provider refusal of implant removal were also other factors triggering unmet need. Empowering women with knowledge of the risk of pregnancy and FP use during an extended postpartum period should be enhanced. Further awareness creation should be extended to periphery at different levels of the community.
Validation of the Revised Knox Preschool Play Scale for the Brazilian Population
Authors: Sposito Amanda Mota Pacciulio , Santos Jair L. F. , Pfeifer Luzia Iara
Published: May 2019

Background. Play is essential to child development, and its evaluation is considered valid to indicate the stage of development of the child and indicate possible lagging. The Revised Knox Preschool Play Scale (RKPPS) provides an evolving description of the typical play behavior of preschool children, in six-month periods from zero to three years of age and then in annual periods up to six years of age. The RKPPS has already undergone the process of cultural adaptation for use in the Brazilian population, and it is necessary to analyze its applicability. Aims. To verify the reliability and internal consistency of the RKPPS for Brazilian children. Method. 135 children participated in the study, divided into different age groups with 15 in each group, and were filmed during free play in school or home contexts. Two independent raters evaluated the footage from two different times. Based on these evaluations, a statistical analysis was carried out in order to ascertain the reliability and the internal consistency of the Brazilian version of the RKPPS. Results. Intra- and interrater reliability showed a predominance of near-perfect to moderate agreement; however, some dimensions of certain age groups presented reasonable to poor agreement. The internal consistency was found to be satisfactory for most of the items evaluated; however, there were items with poor results in some dimensions of certain age groups. Conclusions. There is a need for further analysis of these items by a committee of experts to ensure the reproducibility of the instrument.
Determination of Progestin Residues in Fish by UPLC-Q-TOF/MS Coupled with QuEChERS
Authors: Gu Chunxiu , Cheng Yanling , Zhen Xin , Chen Xiaoxuan , Zhou Kaowen
Published: May 2019

A novel method was developed for simultaneous determination of 10 progestin residues in fish by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) combined with a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The homogenized samples were dispersed by water, extracted with acetonitrile, and then purified by QuEChERS reagent. The concentrated analytes were detected by UPLC-Q-TOF/MS. High linearities (R2 > 0.995) and recoveries (85.71–117.08%) at three spiked levels (5, 10, and 20 ng/g) and low relative standard deviation values (<8.83%, n = 7) and limits of detection (0.23–0.66 ng/g) were obtained. This method is simple, rapid, reliable, sensitive, and efficient and can be used for monitoring of progestin residues in fish. This method provides a strong guarantee to deal with food emergencies for the laboratory, provides technical support for the screening and quantitative detection of progesterone in fish, and provides technical support for the food safety of aquatic products.
Asymptotic Behavior of Almost Quartic ⁎-Derivations on Banach ⁎-Algebras
Authors: Kim Hark-Mahn , Shin Hwan-Yong , Park Jinseok
Published: May 2019

The purpose of this paper is to obtain the stability theorems of quartic ⁎-derivations associated with the quartic functional equation f(3x-y)+f(x+y)+6f(x-y)=4f(2x-y)+4f(y)+24f(x) on Banach ⁎-algebras.
Predicting Success of Two-Stage Exchange for Prosthetic Joint Infection Using C-Reactive Protein/Albumin Ratio
Authors: Hong Cierra S. , Ryan Sean P. , Gabor Jonathan A. , Bergen Michael A. , Schwarzkopf Ran , Seyler Thorsten M.
Published: May 2019

Two-stage exchange is most commonly used for treatment of prosthetic joint infections (PJI) but, this may fail to eradicate infections. C-reactive protein/albumin ratio (CAR) has been used to predict survival and operative success in other surgical subspecialties and so, we assess the association between CAR and reimplantation success during two-stage revision for PJI defined by the Musculoskeletal Infection Society following a primary total hip (THA) or knee (TKA) arthroplasty. From January, 2005 to December, 2015, two institutional databases were queried and patient demographics, antibiotic duration, C-reactive protein, and albumin were collected prior to reimplantation. Two-stage revisions were considered successful if patients were off of antibiotics and did not require a repeat surgery. CAR was available for 79 patients (34 hips and 46 knees) with 61 successful two-stage revisions and 18 failures. The average CAR for patients with successful reimplantation was 1.2 (0.2, 3.0) compared to 1.0 (0.4, 3.2) for treatment failure. However, this was not statistically significant (p=0.766). Therefore, CAR is not applicable in predicting the prognosis of two-stage revisions for PJI in total arthroplasty but other preoperative inflammatory-based prognostic scores should be explored.
Reticulated Open-Celled Zinc Oxide Ceramic Foams: Manufacturing, Microstructure, Mechanical, and Thermal Properties
Authors: Betke Ulf , Scheffler Michael
Published: May 2019

Open-celled zinc oxide ceramic foams were prepared by the polymer sponge replication (Schwartzwalder) technique from aqueous ZnO dispersions with Sb2O3 and Bi2O3 as sintering additives, and mechanically stable ZnO foams with an average porosity of 93.6% were obtained. Their microstructure consists of ZnO grains with a Bi-containing grain boundary phase together with a Zn-Sb-O secondary phase with spinel structure. The obtained ZnO ceramic foams were characterized with respect to their morphology by computed tomography; in addition, the compressive strength and the thermal conductivity were determined, and the data were applied for modelling of the mechanical and thermal properties of the bulk ZnO strut material.
The Fractal Geometry of the Cosmic Web and Its Formation
Authors: Gaite Jose
Published: May 2019

The cosmic web structure is studied with the concepts and methods of fractal geometry, employing the adhesion model of cosmological dynamics as a basic reference. The structures of matter clusters and cosmic voids in cosmological N-body simulations or the Sloan Digital Sky Survey are elucidated by means of multifractal geometry. A nonlacunar multifractal geometry can encompass three fundamental descriptions of the cosmic structure, namely, the web structure, hierarchical clustering, and halo distributions. Furthermore, it explains our present knowledge of cosmic voids. In this way, a unified theory of the large-scale structure of the universe seems to emerge. The multifractal spectrum that we obtain significantly differs from the one of the adhesion model and conforms better to the laws of gravity. The formation of the cosmic web is best modeled as a type of turbulent dynamics, generalizing the known methods of Burgers turbulence.
Improving Wood Resistance to Decay by Nanostructured ZnO-Based Treatments
Authors: Weththimuni Maduka L. , Capsoni Doretta , Malagodi Marco , Licchelli Maurizio
Published: May 2019

In this study, the maple wood surface was coated with nanostructured zinc oxide, grown on the surface by using a hydrothermal process, and furtherly treated with shellac varnish. Samples obtained both after ZnO treatment and after the final varnish application were characterized by different techniques, i.e., X-ray diffraction (XRD), scanning electron microscopy combined with energy-dispersive X-ray spectroscopy (SEM-EDS), micro-FTIR with attenuated total reflectance (μ-ATR-FTIR), chromatic variation measurements, and contact angle determinations. Analytical results showed that the wood surface was covered by quite a homogeneous array of inorganic nanoparticles and that the natural resin forms a regular film over the ZnO nanostructures. An accelerated aging test was used to evaluate the protecting effectiveness of the treatments towards UV-induced decay of wood material. After the test, wood treated with ZnO and with the shellac/ZnO combination underwent a considerably lower chromatic change if compared to the untreated wood, suggesting an enhanced resistance of the treated maple to the decay due to light exposition. The presence of nanostructured ZnO protects from decay not only the wood substrate but also the shellac film. A microbiology test showed that growth of fungal species, e.g., common mold, is prevented on the wood surface treated with ZnO or with shellac/ZnO, indicating that the nanostructured zinc oxide also provides an effective protection from biodeterioration. The coating obtained by consecutive application of nanosized ZnO particles and shellac varnish combines the excellent aesthetical features and water repellence of the traditional finish with the protecting effectiveness of the nanostructured inorganic component.
Experimental Investigation of the Permeability Measurement of Radial Flow through a Single Rough Fracture under Shearing Action
Authors: Tan Ran , Chai Junrui , Cao Cheng
Published: May 2019

Water flow is commonly observed in rock fractures, and this flow has considerable significance in many aspects of rock engineering. In this study, seepage‐stress coupled tests were performed on fractured rock masses using a computer‐controlled direct shear device for rock with seepage control. The flow direction was radial. Eight types of test case were designed, and subgroup tests with varied normal stress, shear velocity, and roughness of fracture surface were conducted. The failure state of the fracture surface after the shear test, changes in shear stress, and fissure width and permeability under the above conditions were analyzed. The results include the following: the grain size of gouge fragments produced in rough fracture decreased with an increase in normal stress during shearing; the grain size of gouge fragments affected the fracture permeability; and the influence of shear velocity on the test results was mainly reflected after the peak strength. Additionally, a new expression describing fluid flow through fracture gouge is proposed.
Assessment of Flexural Behavior of Pultruded GFRP Laminates for Bridge Deck Applications
Authors: Zhang Youyou , Mosallam Ayman , Liu Yuqing , Sun Yun , Xin Haohui , He Jun
Published: May 2019

In this study, flexural behaviors of the pultruded composite laminate were evaluated through experiments and theoretical analysis. Three-point flexural tests were performed for pultruded specimens. The typical failure mode for the longitudinal flexural specimens was local crush on the top surface accompanied with local cracks on the bottom surface at midspan. For the transverse tests, the specimens presented a failure pattern with local cracks initiated and propagated at both the top and bottom sides at the midspan. Theoretical analysis, based on micromechanics and macromechanics, was performed to predict flexural deformation and stress distribution of the pultruded laminate beam. Based on the continuum damage model proposed by the authors, this paper mainly investigates the flexural behavior and failure pattern of pultruded lamination. The theoretical and finite element results agreed well with the test results. The results can provide a reference for the design of the structural pultruded modular systems.
Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration
Authors: Xia Kaishun , Zhu Jian , Hua Jianming , Gong Zhe , Yu Chao , Zhou Xiaopeng , Wang Jingkai , Huang Xianpeng , Yu Wei , Li Liming , Gao Jianqing , Chen Qixin , Li Fangcai , Liang Chengzhen
Published: May 2019

Background. Cell replacement therapy is an attractive alternative for treating degenerated intervertebral discs (IVDs), which are related to the reduction of nucleus pulposus-like cells (NP-lCs) and the loss of the extracellular matrix. Induced pluripotent stem cells (iPSCs) which resemble embryonic stem cells are considered to be a potential resource for restoring NP-lCs and disc homeostasis. Here, we proposed an efficient two-step differentiation protocol of human iPSCs into NP-lCs and continuously tested their in vivo ability to regenerate IVDs. Methods. A polymeric gelatin microsphere (GM) was generated for sustained release of growth and differentiation factor-5 (GDF-5) and as a cell delivery vehicle of NP-lCs. By injecting NP-lC-seeded GDF-5-loaded GMs into the rat coccygeal intervertebral discs, the disc height and water content were examined with the molybdenum target radiographic imaging test and magnetic resonance imaging examination. Histology and immunohistochemistry results were shown with H&E, S-O-Fast Green, and immunohistochemistry staining. Results. We demonstrated that the injection of NP-lC-seeded GDF-5-loaded GMs could reverse IDD in a rat model. The imaging examination indicated that disc height recovered and water content increased. Histology and immunohistochemistry results indicated that the NP cells as well as their extracellular matrix were partially restored. Conclusions. The results suggest that NP-lC-seeded GDF-5-loaded GMs could partially regenerate degenerated intervertebral discs after transplantation into rat coccygeal intervertebral discs. Our study will help develop a promising method of stem cell-based therapy for IDD.
Mining the Hidden Link Structure from Distribution Flows for a Spatial Social Network
Authors: Zheng Yanqiao , Zhao Xiaobing , Zhang Xiaoqi , Ye Xinyue , Dai Qiwen
Published: May 2019

This study aims at developing a non‐(semi‐)parametric method to extract the hidden network structure from the {0,1}‐valued distribution flow data with missing observations on the links between nodes. Such an input data type widely exists in the studies of information propagation process, such as the rumor spreading through social media. In that case, a social network does exist as the media of the spreading process, but its link structure is completely unobservable; therefore, it is important to make inference of the structure (links) of the hidden network. Unlike the previous studies on this topic which only consider abstract networks, we believe that apart from the link structure, different social‐economic features and different geographic locations of nodes can also play critical roles in shaping the spreading process, which has to be taken into account. To uncover the hidden link structure and its dependence on the external social‐economic features of the node set, a multidimensional spatial social network model is constructed in this study with the spatial dimension large enough to account for all influential social‐economic factors. Based on the spatial network, we propose a nonparametric mean‐field equation to govern the rumor spreading process and apply the likelihood estimator to make inference of the unknown link structure from the observed rumor distribution flows. Our method turns out easily extendible to cover the class of block networks that are useful in most real applications. The method is tested through simulated data and demonstrated on a data set of rumor spreading on Twitter.
Mesenchymal Stem Cells Derived and Cultured from Glioblastoma Multiforme Increase Tregs, Downregulate Th17, and Induce the Tolerogenic Phenotype of Monocyte-Derived Cells
Authors: Tumangelova-Yuzeir Kalina , Naydenov Emanuil , Ivanova-Todorova Ekaterina , Krasimirova Ekaterina , Vasilev Georgi , Nachev Sevdalin , Kyurkchiev Dobroslav
Published: May 2019

Mesenchymal stem cells (MSCs) possess immunosuppressive properties and have been described in the tumor microenvironment of glioblastoma multiforme (GBM). This manuscript has two major topics—first, to describe isolated and cultured MSCs derived from GBM (GB-MSCs) and second, to examine theirin vitroimmunosuppressive capacity. Our results display cells with morphology and phenotype, clonogenic ability, and osteogenic potential, typical for MSCs. Furthermore, the cultured cells show intracellular expression of the neural markers Nestin and GFAP. They express PD-L1 and secrete TGFβ, CCL-2, PGE2, IL-6, and sVEGF. Coculturing of GB-MSCs with PBMCs isolated from healthy donors results in a decreased percentage of Th17 lymphocytes and an increased percentage of Tregs. Regarding the impact of GB-MSCs on monocytes, we establish an augmented expression of CD14 and CD86 along with diminished expression of HLA-DR and CD80, which is associated with tolerogenic phenotype monocyte-derived cells. In conclusion, our results describe in detail GBM-derived and cultured cells that meet the criteria for MSCs but at the same time express Nestin and GFAP. GB-MSCs express and secrete suppressive molecules, influencingin vitroT cells and monocytes, and are probably another factor involved in the immune suppression exerted by GBM.
The Partial Second Boundary Value Problem of an Anisotropic Parabolic Equation
Authors: Zhan Huashui
Published: May 2019

Consider an anisotropic parabolic equation with the variable exponents vt=∑i=1n(bi(x,t)vxipi(x)-2vxi)xi+f(v,x,t), where bi(x,t)∈C1(QT¯), pi(x)∈C1(Ω¯), pi(x)>1, bi(x,t)≥0, f(v,x,t)≥0. If {bi(x,t)} is degenerate on Γ2⊂∂Ω, then the second boundary value condition is imposed on the remaining part ∂Ω∖Γ2. The uniqueness of weak solution can be proved without the boundary value condition on Γ2.