bluuebunny/crossref_metadata_2025 huggingface dataset:
The risk of arrhythmia by calculating with new electrocardiographic parameters in pregnant women with heart failure
Authors: GÖÇER Hakan , KAYACIK GÜNDAY Özlem , ÜNAL Mustafa
Published: November 2018

Aim: To evaluate cardiac arrhythmias with surface 12 lead electrocardiography
(ECG) parameters during pregnancy
in women with mild heart failure. Material and Cardiovascular
deaths usually occur in older pregnancies and arrhythmia is the third most
common cause. Our study aimed to determine whether the risk of arrhythmia
increases in pregnancy with advanced age.Go to:Methods:This cross-sectional study was approved by the local
ethics committee of bicard clinic and our hospital 53 consecutive patients were
accepted. All patients were admitted to hospital for cesarean section. Patients
were grouped to heart failure (group 1) and control (group 2) (healthy group). A
12 lead ECG and N-terminal pro B-type
natriuretic peptide (NT-pro BNP) plasma levels was
recorded for every woman at 48 hour before cesarean section. They were evaluated
P wave, qt, qtc and Twave peak to end, preoperative NT-pro BNP and compared statistically.In
total, 280 pregnant women, of whom 98 were of advanced age and 182 were under
35 years of age were included in the study. The risk of arrhythmia was
evaluated by calculating the electrocardiographic P-wave duration, QT interval,
T peak-to-end interval, and the Tp-e/QT ratio.Go to:Results: There were statistically
significant differences in the Tp–e interval and Tp-e/QTc ratio between the two
groups, the maximum QTc, minimum QTc, and QTc dispersion values, P wave
dispersion were significantly higher in group-1 compared to the group-2. In
addition, preoperative NT-pro BNP plasma levels was greater in the group 1
pregnant women. And there was a positive correlation between ECG parameters and
NT-pro BNP plasma levels in group 1.Although
there were no differences in the Tp-e interval and Tp-e/QTc ratio between the
groups, the maximum QTc, minimum QTc, and QTc dispersion values were significantly
higher in advanced-age pregnancies compared to the control group. In addition,
the P dispersion was greater in advanced-age pregnancies. In correlation
analysis, the increased dispersion of QTc and P were positively correlated with
maternal age. Multiple linear regression analysis showed that QTc dispersion
was independently associated with maternal age.Go to:

Conclusion: In conclusion, repolarization
parameters were increased in patients with heart failure with elevated NT-pro
BNP. Pregnancy and heart failure has known risk for pregnant women. But there is
no clear cut atrial and ventricular arrhythmias risk scoring parameters for these
kind patients. We found that ECG parameters which had significantly different
in pregnant women with heart failure than control group and these changes correlated
with NT-pro BNP levels. This is pathological; arrhythmia risk scorings should
be established to reduce mortality and morbidity in heart failure patients with
elevated BNP levels.
Message from Editor
Authors: Tayauova Gulzhanat
Published: November 2018

Dear Readers,It is the great honor for us to publish seventh volume, second issue of Global Journal of Business,Economics and Management: Current Issues.
Responsible sourcing practices in hazelnut industry
Authors: Yigit Sema , Mumcu Ahmet
Published: November 2018

Companies may play an important role to guarantee the supply of their basic raw ma terials and hereby to support sustainability. The aim of this study is to investigate the companies’ responsible sourcing practices in hazelnut industry in Turkey. Turkey is the world’s leading producer and exporter of hazelnuts, accounting for around 75% of the world’s supply. Survey, interview and analysis of secondary data method were used together. Responsible sourcing practices of companies were analysed into two parts as assessment and collaboration. Besides, under-age workers on hazelnut production are one of the major problems that companies ha ve to struggle to prevent it in the context of responsible sourcing.
Keywords: Responsible sourcing, hazelnut, Turkey
Applicable quality management tools in a production cycle of a selected company
Authors: Zach Martin
Published: November 2018

The paper deals with quality control in a Czech manufacturing company, especially at its quality department. The objective is to define the identified production failures, using selected quality management tools, and to determine the causes of technological problems. The following methods and tools were used: cause and effect analysisâ€”Fishbone diagrams (Ishikawa diagrams); Pareto charts, flowcharts and others methods, whose results have been visually displayed. Based on a detail analysis of the production failures, the proposal to eliminate them as well as a draft implementation of the corrective action and its effect on enhancing quality in the production company are presented. The elements such as frequency of controls, adherence to regular inspections and replacement of filters in air conditioning units, cleaning and compliance with the work rules were monitored, as these elements have an impact on product quality and customer satisfaction. The implementation of the corrective actions and the related financial estimate are presented.

 

Keywords: Quality, production process, quality management tools, quality management, implementation, Pareto diagrams, cause and effect diagrams, safety.
Websites of Slovak sports clubs-Analysis, evaluation and recommendations
Authors: Varmus Michal , Vodak Josef , Ferenc Patrik
Published: November 2018

The paper analyses the websites of sports teams of most popular Slovak sports. For assessment were established 13 parameters. The evaluation focused on the relationship of the club through the website with fans, sponsors and youth. The results of this analysis shows the shortcomings and common features various clubs, in view of the approach to addressing the issue. This article also shows the difference between the clubs and their approach with regard to the sports sector in which they operate.

 

Keywords: Web site; Critical Success; Factors; Sport; Marketing
Shareholder value: An analysis of return on assets and equity and their impact on corporate strategic donation using profit margin and turnover
Authors: Arhin Solomon
Published: November 2018

Return on Assets(ROA) and Return on Equity(ROE) are key performance indicators that the investors of company shares always look at to assess their future earning potentials. Any shareholder who anticipates a decline in return on his assets or equity in the form of shares usually takes proactive step to avoid such an unprecedented, unforeseen and undesired events to happen.  From the biblical perspective, in Mathew 25:27, investors put their moneys into the bank to obtain interest. This study focuses on establishing relationship between Return on Asset and Return on Equity  using Gross margin and Turnover as a model of Corporate strategic Donation in the selected firms. The population for the study is made up all the companies registered with Security and Exchange Commission database. The study uses sample size of consolidated financial statement of 471 subsidiaries that were registered and reported their financial statement with Security and Exchange database. It is a quantitative study that used IBM SPSS version 21 to analyze the data obtained from the secondary source. The responses received were analyzed   through descriptive statistics in the form of percentages, mean score , standard deviation , Simple and Multiple Regression Analysis and ANOVA tests  to determine how the various groups within the data collected may have greater or lesser influence on the success of Corporate strategic Donation as discretionary management tool. The research reveal that Corporate strategic Donation does not  have adverse impact on the measurement of Return on Asset(ROA,) and Return on Equity(ROE,) as the main dependable variables used in the analysis . While Turnover has positive impact on Corporate Strategic Donations, Profit Margin has negative relationship with Corporate Strategic Donation. The study concluded that emerging firms from the downturn were committed to their communities, but also seeking to generate a bigger impact with their contributions. The study recommends that future researchers can  use  large sample size  to show the relationship between corporate donations and their resultant effect on  shareholder returns.
Precious metals market in the new millennium
Authors: Badura Peter , KalusovÃ¡ Lenka , KmeÅ¥koc Miroslav , SedliaÄikovÃ¡ Mariana , VavrovÃ¡ KatarÃ­na
Published: November 2018

In the ever-changing investment environment it is not easy to find a relatively safe investment option. That is the reason why a large part of investors (respective both, the financial science as well as the financial practice) is increasingly concerned with the benefits and risks of investing into precious metals. The aim of this paper was to find out how the prices of gold, silver, platinum and palladium have been behaving in the last 15 years, from January 2001 to December 2015. The prices of selected precious metals, their cross-correlation and their volatility in the last millennium as well as the relation of precious metals prices to S&P 500 index values have been analyzed. The method of correlation analysis has been used as the main research method. Our findings showed that despite the fact that some of the precious metals seemed to be a good choice as a profitable investment none of them have been a good choice for investment diversification, neither with each other nor with the S&P 500 index that represented the stock market. The precious metals can be easily used as a form of financial investments. Unlike S&P 500 index or some other underlying assets the precious metals (especially gold) are financial instruments that are liquid in any part of the world.

Â© 2016 The Authors. Published by Elsevier B.V.

Peer-review under responsibility of Academic World Research and Education Center.

Keywords: precious metals; S&P 500 index; price correlations; standard deviation; new millennium;
Message from Editor
Authors: Bektas Prof. Dr. Cetin
Published: November 2018

Dear Readers,

It is the great honor for us to publish seventh volume, second issue of Global Journal of Business, Economics and Management: Current Issues.

 

Global Journal of Business, Economics and Management: Current Issues is an international, multi- disciplinary, peer-refereed journal which aims to provide a global platform for professionals working in the field of business, economics, management, accounting, marketing, banking and finance and scholars and researchers to share their theoretical, empirical and practical knowledge on current issues in the area of business, economics and management.

 

The scope of Global Journal of Business, Economics and Management: Current Issues includes; but is not limited to current issues on; Accounting, Advertising Management, Business and Economics, Business Ethics, Business Intelligence, Business Information Systems, Business Law, International Finance, Labor Economics, Labor Relations & Human Resource Management, Law and Economics, Management Information Systems, Business Law, Business Performance Management, Business Statistics, Communications Management, Comparative Economic Systems, Consumer Behavior, Corporate Finance and Governance, Corporate Governance, Cost Management, Management Science, Market Structure and Pricing, Marketing Research and Strategy, Marketing Theory and Applications, Operations Research, Organizational Behavior & Theory, Organizational Communication, Prices, Business Fluctuations, and Cycles, Product Management, Decision Sciences, Development Planning and Policy, Economic Development, Economic Methodology, Economic Policy and so on.
Effectiveness measurement of spectral clustering algorithm
Authors: Kuwil Farag Homed Ali
Published: November 2018

Abstract

 

After the Kuwil method was found for applying the spectral clustering algorithm, we need a way to make sure of the results, because in many cases the nature of data is not compatible with the algorithm; also, when the data contain more than three dimensions (3D) the results cannot be displayed on the monitor. So I found two techniques, first, for measuring the strength and effectiveness of S.C.A, such as some comparative relationships that measure the following: Effectiveness of algorithm applying, the strength of every cluster and the effectiveness of data correlation inside every cluster. Secondly, analysis of variance (ANOVA) for S.C.A; this depends on distance variance instead of values variance. I applied the methods above to calculate the strength and effectiveness of S.C.A, and they showed good results, so they can offer more reliability for the outputs of the algorithm. Using these relations and ANOVA for S.C.A help us to measure the data receptivity for applying the algorithm by â€˜Kuwil methodâ€™, so the outputs will be more reliable and that will help to spread the use of this algorithm among researchers, analysts and other users.

Keywords: Spectral clustring, algorithm effectiveness, Kuwil method.
Effects of fixed and roaming CN on MIPv6 networks
Authors: Djassi Papa
Published: November 2018

Mobile Internet protocol version 6 (MIPv6) is a protocol that allows mobile nodes (MNs) to remain accessible while moving in the IPv6 network, providing users with a form of transparency in spite of the mobility. Mobile networks consist of different nodes such as the MN, correspondent node (CN), home agent (HA), foreign agent or router (FA or FR) and mobile router (MR). One of the vital nodes in a mobile network is CN, a node that communicates with the MN. In the future, in times of need, for instance, during wars, disasters or natural hazards, an MN may require the services of a CN in order to roam. In this paper, we analyse the effect of fixed and roaming CN on MIPv6 networks. The results show that, with a fixed CN, the delay variation performance, end-to-end delay and packet received are better than having a roaming CN in the mobile networks. This requires the attention of researchers, especially when all the communicating nodes (i.e., MN and CN) are roaming in the mobile networks to reduce the delay and packet drop, especially during the handover process.

Keywords: MIPv6, fixed CN, roaming CN, MN, HA and FA.
Performance analysis of software maintenance process using stochastic Petri nets
Authors: Nabeel Muhammad , Anwar Zeeshan , Ahsan Ali
Published: November 2018

Software maintenance is a time taking activity in the real world. Execution time of software maintenance process may get increased due to interdepartmental communication, thus, increasing the cost and decreasing the performance of the process. We suggested performance evaluation of software maintenance process through the transformation of activity diagram into generalised stochastic Petri nets (GSPN). For this study, execution time and cost of maintenance process are defined as performance measures, and the role-based approach is used to understand the flow of software maintenance activities in a software organisation. Activity diagram is constructed to be transformed into GSPN. We used PIPE2 to analyse the GSPN. PIPE2 calculates average number of tokens on a place in the GSPN, throughput of timed transition and state space analysis. State space involves calculation of the reachability of the GSPN net that shows whether a GSPN holds the property of safeness, boundness and is deadlock free.

 

Keywords: Generalised stochastic Petri nets (GSPN), GSPN analysis, performance evaluation, performance modelling, software maintenance process, stochastic Petri nets.
Study and identification of short-circuit currents at the complex distribution network SIDER EL Hadjar (ex ArceloMittal-Algerie)
Authors: Hakim Benhamida , Tarek Mesbah
Published: November 2018

Because of an upcoming modernisation of the electricity distribution network in the SIDER EL HADJAR steel complex, a new calculation of the short-circuit current must be taken into account. The objectives are to determine the precise values of the currents of maximum and minimum fault by each start 225 kV, 63 kV and 15 kV of the distribution network to ensure the reliability of the existing system, and to validate the sizing of the 63 kV bus bar follows the increase of the load of the transformer station P4 by replacing the 70 MVA transformer with a 120 MVA transformer and comparing the results to the old computation. The calculation of short-circuit currents is a key step in qualifying the equipment to withstand the thermal and electromagnetic effects. So, to appreciate the reliability of numerical computation of the currents of short circuits requires modelling and simulations with software NEPLAN V5.

Keywords: Initial short-circuit current, power supply system (SIDER EL HADJAR), IEC 60909-0, peak value of short-circuit current, NEPLA software.
A technological platform for the creation and evaluation of psycho-technical tests
Authors: Almeida Fernando , Castelo Daniela
Published: November 2018

This paper proposes the development of a technological platform for support of psycho-technical tests in higher education institutions. This subject deals with a topic extremely important for the institution and for students, because the platform will serve internally to assist students in preparing them for the professional life. The application is web hosted and exclusively built using open source technologies. The application allows teachers to create new psycho-technical tests in various technical and scientific fields. Each psycho-technical test is composed of several multiple-choice questions, and the teacher may specify the list of alternative answers and indicate a maximum response time for each question. For its part, the students can visualise the list of psycho-technical tests available organised by subject. The platform registers the performance of students in several domains and allows students to practice and improve their skills. In this way, students may be better prepared for job interviews and, consequently, for the job market.
Keywords: Psycho-technical tests, web applications, software engineering, student evaluations, information technology.
Implementasi Fitur Haar-like dalam Mendeteksi dan Menghitung Jumlah Orang pada Noised Digital Image
Authors: Hidayatur-Rohman Qisthi Al Hazmi
Published: November 2018

Mendeteksi objek pada citra digital bagi manusia pada umumnya merupakan hal yang tidak sulit, namun tidak bagi komputer. Komputer membutuhkan teknologi khusus untuk mengolah suatu citra hingga dapat mendeteksi objek pada citra digital. Visi komputer memberikan solusi pada komputer untuk dapat mendeteksi objek pada citra digital. Salah satu fitur yang dapat diimplementasikan adalah Fitur Haar-like. Dengan fitur Haar-like, komputer akan mengekstraksi citra digital yang nantinya akan dideteksi suatu objek pada citra tersebut dengan algoritma Viola-Jones, yaitu algoritma cascade classifier yang berfungsi untuk mendeteksi suatu objek pada citra berdasarkan data citra terlatih (trained data). Pada penelitian ini, Fitur Haar dapat mendeteksi objek pada citra digital dengan tiga kondisi yang berbeda, yaitu saat kondisi normal, kondisi citra dengan derau, dan kondisi citra dengan pencahayaan rendah. Visi komputer dengan Fitur Haar-like dapat mendeteksi objek pada ketiga kondisi citra tersebut dengan prosentase kesalahan yang cukup rendah.
Emendas temporais e provisórias: que processo legislativo é este?
Authors: Bonizzato Luigi , Monteiro Julia Iunes , Moulin Isabelle Esteves
Published: November 2018

O presente artigo jurídico, valendo-se de estudo investigativo histórico, consolidado por meio da análise de todas as Emendas, relativas a todas as Constituições brasileiras, desde a independência do Brasil, procede a um exame comparativo e, de modo bem delimitado e recortado, qualitativo, da Emenda Constitucional nº 91, de 18 de fevereiro de 2016. Para além do já dito, os Autores utilizam método dedutivo, após rigorosos levantamentos de dados e obtenção de resultados para, também com base na Constituição de 1988 e em teorias jurídicas, abordar, já no capítulo primeiro, o processo legislativo brasileiro e sua relação com a referida Emenda nº 91. Por fim, no segundo e último capítulo, a pesquisa histórico-comparativa é diretamente utilizada para que conclusões sejam tiradas e sedimentadas, com base, reforce-se, no objeto de estudo e na escolha temática, ambos direcionados à realidade jurídica, política, constitucional e institucional do país.
A relação entre inovação e controle da administração pública
Authors: Jordão Eduardo
Published: November 2018

Este artigo discute a relação bidirecional entre inovação e controle da administração pública. Primeiramente, examina o impacto da inovação sobre o controle, ilustrando como novas tecnologias, processos ou ideias podem impactar a atividade de fiscalização da atuação das autoridades administrativas. Em seguida, busca discutir a medida em que o controle da administração pública pode incentivar ou limitar o desenvolvimento de novas ideias e novas tecnologias na sociedade e na administração pública.
Serviço Social Autônomo: alternativa à implementação de políticas públicas não exclusivas de Estado
Authors: Cunha Junior Luiz Arnaldo Pereira da , Saddy André , Knopp Glauco da Costa , Aureliano Junior Eurípedes
Published: November 2018

Este artigo tem como objetivo geral traçar a origem e a evolução do modelo Serviço Social Autônomo no Brasil, além de demostrar que o conceito veiculado pela doutrina pátria está defasado, desconsiderando a realidade fática e jurisprudencial, motivo pelo qual se estabelece um conceito mais preciso e atual de Serviço Social Autônomo, identificando suas principais características. Para alcançar este objetivo, apoiou-se fundamentalmente nas normativas que regulamentam a criação e o funcionamento dessas entidades, além de fazer uma análise, de forma complementar, na doutrina e da jurisprudência sobre o tema. Ao todo foram identificadas 36 (trinta e seis) SSAs, até dezembro de 2017, sendo 31 (trinta e um) em funcionamento, 03 (três) extintos, 01 (um) transformado em outro modelo, 01 (um) em liquidação extrajudicial e, também, a existência de Projetos de Lei para criação de mais entidades na esfera federal. Destas em funcionamento, 13 (treze) foram criadas por Leis Federais, 11 (onze) por legislação estadual e 06 (seis) por legislação municipal e 01 (um) por legislação distrital. Deste total, 04 (quatro) formam o Sistema “S” original e outros 04 (quatro) são fruto da expansão deste sistema, já os outros representam a derivação do modelo original, com atuação em diversas áreas: assistência, educação, meio ambiente, desenvolvimento científico e tecnológico, desenvolvimento econômico, desenvolvimento urbano, previdência, saúde e apoio à promoção agropecuária.
Big Data in the public sector
Authors: Bellocchio Lucía
Published: November 2018

There is no doubt that one of the most obvious and far-reaching derivations of the Internet and global interconnection through the network is the enormous volume of information to which we have access. It is in this context that the so-called "Big Data" appears, exposing us to great changes in the different areas of our lives, proposing scenarios that point to open governments, transparency and greater closeness to citizens. However, there are many challenges that this new reality poses on Public Administration and there appears not to be unique strategies or models for its implementation. The aim of this work is to review some of the most important concepts that are involved in this era of Big Data in the public sector.
Are Personas Done? Evaluating Their Usefulness in the Age of Digital Analytics
Authors: Salminen Joni , Jansen Bernard J. , An Jisun , Kwak Haewoon , Jung Soon-gyo
Published: November 2018

In this research, we conceptually examine the use of personas in an age of large-scale online analytics data. Based on the criticism and benefits outlined in prior work and by practitioners working with online data, we formulate the major arguments for and against the use of personas given real-time online analytics data about customers, analyze these arguments, and demonstrate areas for the productive employment of data-driven personas by leveraging online analytics data in their creation. Our key tenet is that data-driven personas are located between aggregated and individual customer statistics. At their best, digital data-driven personas capture the coverage of the customer base attributed to aggregated data representations while retaining the interpretability of individual-level analytics; they benefit from powerful computational techniques and novel data sources. We discuss how digital data-driven personas can draw from technological advancements to remedy the notable concerns voiced by scholars and practitioners, including persona validation, inconsistency problem, and long development times. Finally, we outline areas of future research of personas in the context of online analytics. We argue that to survive in the rapidly developing online customer analytics industry, personas must evolve by adopting new practices.
Getting Under The(ir) Skin: Applying Personas and Scenarios with Body-Environment Research for Improved Understanding of Users’ Perspective in Architectural Design
Authors: Doktor Olsen Tvedebrink Tenna , Jelić Andrea
Published: November 2018

The aim of this paper is to move established positions in architectural design by discussing a more refined user perspective. The motivation is threefold. Firstly, fields like environmental psychology and cognitive science for architecture have in recent years brought novel insights on the embodied nature of human spatial experience, and the extensive effects of the built environment on people’s psychosomatic health and behaviour that are not well-captured by existing building standardization systems. Secondly, while the fast growing trends of user-centred and research-based design in architecture have showed that users’ experience is a valuable source of design knowledge, the methods for incorporating this wealth of new insights in the architectural design process are still underdeveloped. Finally, the example of the newly built psychiatric department in Aabenraa, Denmark, whose interior, despite an international architectural award in 2016, had to be re-designed one year after construction due to poor understanding of the users, indicates existing discrepancies in the current approaches to translating research information in user-centred design.
 
To address these issues, we discuss the experiences from a new masters’ course in ‘Architecture, Health, and Well-being’ and propose that user-centred methods like ‘personas’ and ‘scenarios’ used in IT, marketing, and product development also have a potential to develop more in-depth research-informed user perspectives. As well as, to help students envision and strengthen the architectural quality of the programming and building design throughout the architectural design process, by supporting a ‘design empathic’ understanding and immersion in user perspectives.
Design Personas – New Ways, New Contexts
Authors: Nielsen Lene
Published: November 2018

Design personas have, since their origins in the late 1990s, been recognised as a design tool to foster ideation and empathy with different user groups. The method originates from software development and has since its instigation become a widespread method adopted in many design disciplines and processes, such as innovation and ideation of IT products, User Experience design, agile systems developing, communication, and marketing (Nielsen 2012; Pruitt & Grudin 2003). To get product design closer to the everyday lives of the users, design personas are a means to capture the everyday experiences and needs of users and customers. Focusing on the user or customer in the design process is in opposition to an artistic understanding of the designer as someone who, by experimentation with materials and form, gets inspiration to create unique products.
Premedication with intranasal dexmedetomidine decreases barbiturate requirement in pediatric patients sedated for magnetic resonance imaging: a retrospective study
Authors: Uusalo Panu , Lehtinen Mirjam , Löyttyniemi Eliisa , Manner Tuula , Scheinin Mika , Saari Teijo I.
Published: November 2018

Background: Barbiturates are commonly used in ambulatory sedation of pediatric patients. However, use of barbiturates involve risks of respiratory complications. Dexmedetomidine, a highly selective α2-adrenoceptor agonist, is increasingly used for pediatric sedation. Premedication with intranasal (IN) dexmedetomidine offers a non-invasive and efficient possibility to sedate pediatric patients undergoing magnetic resonance imaging (MRI). Our hypothesis was that dexmedetomidine would reduce barbiturate requirements in procedural sedation.

Methods: We included 200 consecutive pediatric patients undergoing MRI, and analyzed their hospital records retrospectively. Half of the patients received 3 μg/kg of IN dexmedetomidine (DEX group) 45-60 min before MRI while the rest received only thiopental (THIO group) for procedural sedation. Sedation was maintained with further intravenous thiopental dosing as needed. Thiopental consumption, heart rate (HR) and peripheral oxygen saturation were recorded.

Results: The cumulative thiopental requirement during MRI was (median and interquartile range [IQR]) 4.4 (2.7-6.0) mg/kg/h in the DEX group and 12.4 (9.8-14.8) mg/kg/h in the THIO group (difference 7.9 mg/kg/h, 95% CI 6.8–8.8, P < 0.001). Lowest measured peripheral oxygen saturation remained slightly higher in the DEX group compared to the THIO group (median nadirs and IQR: 97 (95-97) % and 96 (94-97) %, P < 0.001). Supplemental oxygen was delivered to 33 % of the patients in the THIO group compared to 2 % in the DEX group (P < 0.001). The lowest measured HR (mean and SD) was lower (78 (16) bpm) in the DEX group compared to the THIO group (92 (12) bpm) (P < 0.001).

Conclusion: Premedication with IN dexmedetomidine (3 μg/kg) was associated with markedly reduced thiopental dosage needed for efficient procedural sedation for pediatric MRI.
DIAGNOSTIC METHODS OF CANINE TRANSMISSIBLE VENEREAL SARCOMA
Authors: Pashkevych Iryna , Stybel Volodymyr , Soroka Natalia
Published: November 2018

Modern diagnostic of oncological diseases, along with classical clinical and morphological methods, provides for the mandatory use of instrumental immunological, immunocytochemical and molecular genetic research methods. The main tasks of such a complex of diagnostic measures are aimed at monitoring oncological diseases at all stages of the diagnostic and treatment process, namely: the detection of a tumor at early stages of its development and the study of changes in metabolic processes in the body under the influence of neoplasms, morphological confirmation of the diagnosis, identification of histostructure and histogenesis of the tumor, determination the degree of its malignancy, detection of metastatic lesion (regional and distant lymph nodes and other organs) or assessment of the risk of its occurrence. It is well know that the early stages of oncological diseases are difficult to diagnose. At the same time, early detection of the disease can save or significantly extend the life of the patient. In such cases, the determination in the blood of specific substances, which are produced by tumors of the respective organs, the so-called oncomarkers, has been successfully used by world medical practice for more than 40 years to establish the affected organ. In combination with instrumental methods (ultrasound, endoscopy, X-ray), diagnostic efficiency is sharply increasing. Successful treatment of malignant tumors is possible under the conditions of their early detection and thorough histological diagnosis. Almost 50 % of the total number of oncologically diseased dogs has tumorous processes in the tissues of their genital organs, aggressiveness and metastasis, which often leads to lethal consequences, even after radical interventions. The aim of our research was to study the histological, cytological and immunohistochemical characteristics of transmissible venereal sarcoma. It has be en established that histologically, the tumor belongs to the low-differentiated round-cellular sarcoma of the alveolar type. Typical is tumor infiltration by lymphocytes, plasma cells, macrophages. Tumor cells are characterized by the presence of a mesenchymal marker vimentine. A positive local reaction on myogenin, cytokeratin and negative on CD31, CD34, S-100 protein and desmin was observed.
INVESTIGATION OF THE CHEMICAL COMPOSITION AND EFFICIENCY OF SEED OIL OF SPINDLE TREE (EUONYMUS EUROPAEA L.) ON THE MODEL OF NON-ALLERGIC DERMATITIS
Authors: Vrubel Olha , Nektegaev Igor , Antonyuk Volodymyr
Published: November 2018

The aim of the research was to study the chemical composition and effectiveness of the seed oil of Spindle tree (Euonymus europaea L.) on the non-allergic contact dermatitis model.

The oil was obtained by the extraction by petroleum ether from the seeds. The analysis of fatty acids and determination of their quantitative content was carried out using gas chromatography. Determination of carotenoids and tocopherols content in fatty oils was carried out after chromatography on a silica gel column. Investigation of anti-inflammatory action of the Spindle tree seed oil on white rats was carried. Determination of biochemical parameters of blood plasma was performed on the semi-automatic biochemical analyzer BS3000M (Poland).

The yield of oil was 20–28 % of the weight of the seeds. Nine fatty acids were identified in the oil by the gas chromatography, among which 4 are unsaturated (oleic, palmitoleic, linoleic and linolenic), which together make up 87.79 % of all fatty acids from this oil. Spindle tree oil contains 26±5 mg – % carotenoids and 40±5 mg – % tocopherols, which were separated by chromatography on a silica gel column. There were no symptoms of intoxication with the introduction of Spindle tree oil in the stomach of rats and it can be classified in the 4 the grade of danger in accordance with GOST 12.1.005-88.

The anti-inflammatory activity of Spindle tree oil in comparison with the oil of Sea buckthorn on the model of non-allergic contact dermatitis was weaker, but sufficient to recommend it for the treatment of skin diseases in ointments.
PARANOID SCHIZOPHRENIA NEGATIVE SYMPTOMS FEATURES IN CASE OF PRESENCE OF MUSICAL EAR
Authors: Kostyuchenko Natalya , Filts Olexander
Published: November 2018

In our work, we propose one of the options for a prognostic criterion, which at the beginning of the disease can provide sufficient evidence to predict the form and severity of negative symptoms in schizophrenia.

Aim. To investigate the influence of the presence of ear on music on the degree of severity of deficiency symptoms in paranoid schizophrenia.

The study was conducted on the basis of the third clinical department of the Lviv Regional Clinical Psychiatric Hospital for the period of 2015. 40 patients with paranoid form of schizophrenia, aged 18 to 35, were examined, of which: group I – 20 patients with advanced ear on music (average age 28.60±1.01 years) and group II – 20 patients with no ear on music (average age 27.30±1.15 years). The main methods of studying the observation groups were: clinical-psychopathological, pathopsychological, and statistical. The pathopsychological study of the evaluation of negative symptoms was conducted using the "Qualitative Assessment Scale for Positivity, Negative and General Psychopathological Syndromes" (PANSS – Positive and Negative Syndrome Scale), namely, its PANSS-NS subscale. Comparison of the probability of the difference between the average indices of unrelated groups was carried out using the Mann-Whitney method, comparing the relative parameters of the distribution structure by the xi-square criterion.

Analysis of the results of the study shows that in patients with developed ear on music, the level of deficiency symptoms of negative symptoms under the PANSS-NS subclass is 2.2 times lower (p <0.01) than in patients with no developed ear on music: 2.04±0.14 against 4.46±0.17 points, respectively. Comparing the key indicators of the PANSS-NS subscale in patients with paranoid schizophrenia with advanced ear on music, it was found that the manifestations of "Violations of abstract thinking" (N5 – 2.35±0.15 points), "Violation of spontaneity and smoothness in the conversation" (N6 – 2.30±0.15 points) and "Stereotyped thinking" (N7 – 2.20±0.16 points). All these negative symptoms were in patients with muscular earache with significantly lower scores: from lack of severity (1 point) to weakness (3 points). The lack of expressiveness (1 point) was most common in N4 "Passive-apathy social strangeness " - 35.00±10.67 % of patients, very weak severity (2 points) - for N1 "Blurred passion" - 75.00±9.68 % of patients (p <0.05 with the proportion of negative symptoms 1 and 3 points), weakness (3 points) - for N5 – 45.00±11.12 % of patients (p <0.05 with the proportion of negative symptoms 1 point ) The highest proportion (70.00±10.25 %, p <0.05 with a share of negative symptoms of 6 points) of patients with paranoid schizophrenia without ear on music had a high severity (5 points) of rigidity and stereotyping of thinking (N7).

The obtained data prove the influence of the factor of the presence of ear on music on deficit syndrome, as well as on the forms and degree of severity of negative symptoms in paranoid schizophrenia.
INDICATORS OF RESPIRATORY SYSTEM IN CONDITIONS OF CHRONIC ACTION OF HARMFUL ENVIRONMENTAL FACTORS WITH TYPE OF BODY CONSTITUTION
Authors: Pshybelsky Volodymyr , Zhuravlov Oleksandr , Shevchuk Tetiana , Zhuravlova Olena
Published: November 2018

The article presents the results of the study of the peculiarities of the respiratory system functioning in unfavorable environmental conditions in workers involved in industrial production and agrarian sector, taking into account the type of constitution of their bodies. Investigation of the influence of the complex of anthropogenic factors associated with production on the parameters of the respiratory system revealed a significant level of interconnection of the investigated parameters with anthropometric indicators.

During the experiment, a significant decrease in the functional lung capacity in the studied subjects involved in industrial production was shown, compared with the control group and workers of argo-industrial production. Such a trend may be evidence of functional violations of tracheobronchial conduction, which is indirectly confirmed by the values of the Tifno index, which is the main method of an objective assessment of respiratory tract imperfections, and which is characterized by significantly lower values in the group of workers involved in industrial production compared with residents relative to environmentally friendly areas.

The analysis of the pneumatachographic survey performed on the basis of the Pignier index revealed some differences in the functional parameters of the respiratory system in the groups of hyposthenics (capacity of the lungs) and hypersthenics (maximum volume velocity of 75 %). In the group of normosthenics, intergroup differences were found for the values of functional lung capacity in comparison with all groups, and for the Tifno index, the reliable difference between the indicators was noted only between the group of industrial workers and the control group.
«NOVUMEDICAL» DEVICES ARE THE VECTOR OF REALIZATION OF P4 MEDICINE COURSE
Authors: Shuvalova Irina
Published: November 2018

The issues of modern personified preventive medicine, the development of modern methods, courses, technologies of healthy active longevity are in the focus of attention and these issues are relevant. The purpose of the article is to study the influence on prevention of diseases, improving the quality of life by massage and thermal device «NovuМedical» intended for home use.

In the research the analysis of results of the equipment use in 140 patients aged from 61 to 78 years is conducted by the method of comparison and grouping. A significant improvement in the quality of life, stabilization of the psycho-emotional state and blood pressure is noted among 93.5 % of patients. Reduction of pain syndrome is noted among 85 % of patients, reduction in serum cholesterol is noted among 30 %, glucose normalization is noted among 25 % of patients, and 46 % has a tendency to reduce it. A tendency to normalize blood coagulation function is noted among 40 % of patients, that makes prevention and correction of diseases legitimate and necessary, timely with the help of «NovuMedical» devices at home. «NovuMedical» devices allows both to improve well-being, normalize homeostasis, and to form in patients a system of knowledge and skills to improve the quality of life, and include them in active actions for health self-improvement, mental and physical self-improvement. This participatory approach leads to a fundamentally new paradigm of caring and managing health, when not only the social institutions of the state, but also patients themselves are direct and active participants in the process of preserving and strengthening their own health.
SCHEMES OF SOLID-PHASE SPECTROPHOTOMETRIC ANALYSIS OF FOOD OBJECTS
Authors: Kostenko Elizaveta , Butenko Elena , Arseneva Larisa
Published: November 2018

The aim of research is development of approaches to the development of schemes for microelement analysis of food objects. This will make it possible to monitor food quality by simple and affordable methods in factory laboratories.

Based on data on the immobilization of dyes on ion exchangers and on the interaction of metal ions or their complexes with immobilized dyes, solid-phase spectrophotometric (SPS) and photometric methods for determining metal ions in food technology, biotechnology and the environment have been developed.

Techniques are sensitive. High distribution coefficients (D³104 cm3/g) of metal ions help to reduce the detection limit when using immobilized dye as compared to the reaction in solution. Based on the detection limit values (DLV), the proposed sorption-spectrophotometric methods for determining metal ions are second only to the atomic absorption (AAS) determination of Cd (II) and Hg (II) ions and the polarographic determination of Cd (II) ions. However, the proposed methods for the determination of these metal ions are sufficient for the determination of Cd (II) and Hg (II) ions in food products at the MPC level. In the case of determination of Pb (II), Zn (II), Cu (II), Fe (III) ions, the developed methods have advantages over standard methods for determination of metal ions in food products, since they make it possible to determine these ions at a level ≤0.1…0.5 MPC;

Ion exchangers with immobilized dyes and solid-phase spectrophotometric determination methods with their participation are environmentally safe, since they do not require the use of toxic organic reagents; are simple in execution and economically advantageous because of the low cost of used materials and reagents.

The correctness of the results of the determination by the developed methods is proved: by comparison with the results of determinations on standard methods at various analysis objects using the method of additives, standard samples. The relative standard deviation of the developed SPS determination procedures does not exceed 0.10, which indicates satisfactory reproducibility of the results. The developed methods exceed the majority of standard and best analogs, known from the literature, for sensitivity and selectivity. The used methods of analysis are characterized by the simplicity of the experiment, ecological safety, do not require special expensive equipment, highly qualified personnel and a stationary laboratory.
DEVELOPMENT OF THE NEW POINT SCALE OF ORGANOLEPTIC EVALUATION AT MANUFACTURING ORGANIC CAKES
Authors: Tkachenko Alina
Published: November 2018

The article presents the ground of developing the 50-point scale for evaluating cakes by organoleptic parameters. The aim of the article is to create the new point scale of organoleptic evaluation for using at producing organic cakes. It was established, that for today such important parameters as “flavor”, “post-flavor”, “porosity structure” are not always used at the organoleptic evaluation of cakes’ quality. The article describes the recipes of four developed cakes, produced of the organic raw materials – “Grechanyk”, based on buckwheat flour, “Zhytnytsa’, based on rye flour, “Golden amaranth”, based on amaranth flour and “Hempen delight”, based on hempen flour. For evaluating organoleptic characteristics of cakes, there was presented 50-point scale that includes evaluation of the following parameters: form, surface condition, color of crust, condition and color of crumble, porosity structure, smell, taste, flavor, post-taste, malaxation of crumble. Based on the method of expert evaluations, there were determined significance coefficients for each parameter. Thus, coefficient 0,5 was set for the parameters “porosity structure” and 1,5 for “color” and “smell”, the significance coefficient was equal 1 for a series of other parameters. The developed scale provided the following criteria of cakes evaluation: 45–50 points − "perfectly”, 40–44 points − "well", 30–39 points − "satisfactorily”, lower 30 points – “unsatisfactorily”. Based on the developed scale, the developed cakes were evaluated by the gustatory commission. All developed cakes corresponded to the mark “perfectly” by organoleptic parameters. The highest index of the quality level was inherent to the cake “Grechanyk” " – 0,99 at general sum of points for the gustatory evaluation 49,95. The cake Zhytnytsa corresponded to 0,98 by the quality level, "Hempen delight" – 0,96. The lowest quality level was detected in the cake “Golden amaranth” (0,94),that is caused by the specific taste of amaranth flour.
DEVELOPMENT OF RECIPTURES OF CANNED SMOTHIES MADE FROM ZUCCHINI AND FRUITS
Authors: Tokar Anastasiia , Matenchuk Liudmyla , Kharchenko Zinaida , Haidai Iryna , Zahorko Nadiia , Tarasenko Vira , Verkholantseva Valentуna , Palianychka Nadiia , Povorozniuk Inna , Kravchenko Lesia
Published: November 2018

Rational nutrition for a whole year is possible with a well-established system of storage and processing of plant raw materials. Products with vegetable and fruit raw materials due to their availability and nutritional value are in demand among the population. There is a constant interest in new products with increased biological value. The preservation of ascorbic acid, the main source of which is vegetables and fruits, is also affected by the technology of production. Despite the damaging effect of the heat treatment temperature of canned products on thermolabile components, the sterilization regimes should be relaxed. To this end, it has been proposed to produce beverages from vegetables and fruits for scientifically-based recipes, which allows them to be processed at a temperature of 100 °C, as well as juices with pulp and sugar. Smoothie, made on the basis of zucchini with the addition of gooseberries and blackcurrant puree contain respectively 13.3 and 41.8 mg/100 g of ascorbic acid, have an optimal for good perception of the sugar-acid index 21,4-21,5 compared with juices from soft pulp and sugar from gooseberry and black currant, which produces industry. The latter is explained by the fact that instead of sugar syrup, natural juice from zucchini was used in the recipe.