bluuebunny/crossref_metadata_2025 huggingface dataset:
THE COVID-19 PANDEMIC AND INDIAN PHARMACEUTICAL COMPANIES: AN EVENT STUDY ANALYSIS
Authors: Behera Chinmaya , Rath Badri Narayan
Published: March 2021

Although there is a plethora of studies which examine the impact of the COVID-19 pandemic on India’s financial sector, we contribute by investigating the effect of the ongoing COVID-19 pandemic on stock returns of Indian pharmaceutical companies. By employing an event study methodology, our results indicate that the average returns of the pharmaceutical sector are positive during the COVID-19 phase although mixed evidence is found at the firm level. This finding is also robust to alternative model specifications.
Geological Implications for Gas Saturation of Bottom Sediments in Sedimentary Basins in the Southeastern Sector of the East Siberian Sea
Authors: Gresov A.I. , Yatsuk A.V.
Published: March 2021

—We present research results for the geologic structure of the De Long, Aion, and Pegtymel sedimentary basins of the East Siberian Sea. The materials of geological surveys and drilling in their land area and island surroundings, the data obtained from geophysical surveys conducted by Dal’morneftegeofizika, MAGE, and Sevmorgeologiya, and the seismic and deep-drilling data on the U.S. sector of the Chukchi Sea are summarized and analyzed. Pre-Paleozoic strata and the sedimentary cover have been identified throughout the sections of the sedimentary basins, which suggests the existence of a geologic “cover–basement” boundary rather than an arbitrary called “acoustic basement” horizon. The data on the geologic structure and gas saturation of the upper parts of the sedimentary sections were obtained during the study and gas-geochemical testing of core samples and bottom sediments from coastal shallow wells and corers. Gas contained in the rocks and bottom sediments in the study area includes hydrocarbon gases (HCGs) (СН4, С2–С5, and their unsaturated homologues), СО2, Н2, Не, N2, Ar, and, seldom, CO and H2S. The data on gas saturation of bottom sediments and the geochemical parameters of their syngenetic and epigenetic gases are presented. Areas of abnormal saturation of sediments with CO2, СН4, other HCGs, H2, and He (>5, 0.05, 0.001, 0.005, and 0.005 cm3/kg, respectively) have been identified, and maps of the gas saturation patterns in bottom sediments have been compiled. It is established that both gas saturation and distribution are determined mainly by the geologic evolution, tectonics, magmatism, geocryologic conditions, lithologic composition, catagenesis, coal content, bituminosity of sedimentary rocks, and oil and gas potential of the study area.
An Awakening Magmatic System beneath the Udina Volcanic Complex (Kamchatka): Evidence from Seismic Unrest of 2017–2019
Authors: Kugaenko Yu.A. , Saltykov V.A. , Koulakov I.Yu. , Pavlov V.M. , Voropaev P.V. , Abkadyrov I.F. , Komzeleva V.P.
Published: March 2021

—The Udina volcanic complex located in the southeastern part of the Klyuchevskoy group of volcanoes in Kamchatka remained dormant for several thousand years, but the magmatic system beneath the area may be awakening judging by seismic unrest. Seismicity in the area is characterized by data from permanent regional seismic stations and campaign local stations, as well as by data of the Kamchatka earthquake catalog. Seismic activity having nucleated at shallow depths in the vicinities of the Udina volcanoes since October 2017 may reflect a beginning cycle of volcanism. The earthquakes are mainly long-period (LP) 0.5–5 Hz events, which are commonly attributed to the movement of viscous magma and resonance phenomena in magma conduits. Such earthquakes may be a response to inputs of new magma batches to the plumbing system that feeds the volcanoes and thus may be precursors of volcanic unrest. Seismic campaigns of May–July 2018 near the Udina complex provided more rigorous constraints on earthquake coordinates and origin depths and showed that most of the earthquakes originated within 5 km beneath the Bolshaya Udina Volcano. Seismic tomographic inversion using the LOTOS code revealed a zone of high P-wave velocities, low S-wave velocities, and a high vP/vS ratio directly beneath the volcano. Such a combination of parameters typically occurs in active volcanic areas and marks intrusion of partially molten magma and/or liquid fluids. The velocity anomaly detected in 2018 is shallower than that recovered in 2014–2015. The seismic evidence, along with the available geological and geophysical data, record the movement of viscous magma related to the Udina feeding system in the middle crust, which is implicit proof for connection between the intermediate crustal and deep mantle magma sources renewed after a long lull.
Causes of the Occurrence of A-Type Volcanic Rocks in Active Continental Margins (Southern Sikhote-Alin, Russian Far East)
Authors: Grebennikov A.V. , Maksimov S.O.
Published: March 2021

––New isotope-geochemical data on the volcanic complexes of the South Yakut and Martel volcanic depressions in southern Primorye are presented. Their formation in the early Eocene (54.3 Ma) and Late Cretaceous (83.5 Ma), respectively, is evidenced by U–Pb zircon dating (LA-ICP-MS). Based on the geochemical characteristics, it is concluded that the volcanics are typical A-type igneous rocks. Their formation coincides with the sudden change in the vector of motion of the Pacific slab with respect to the continent in the Campanian and Paleocene–Eocene, which caused destruction of the slab with its probable discontinuity and the injection of the subslab asthenosphere. The effect of mantle fluids on the continental lithospheric-rock melting determined the generation of magmas with the specific geochemical features of A-type igneous rocks. The regularities of their composition are due to the deep-seated reduced F-rich fluids that caused the intense differentiation of magmas accumulating fluidized melts enriched in mobile components in the apical part.
Data-Driven Integration to Delineate Zonal Isolation and Casing Deterioration Using Advanced Ultrasonic Technology – A Blueprint to Well Integrity Evaluation
Authors: Khan Mohammad Rasheed , Ahmed Hassaan , Bari Abdul , Rashid Kamran , Ali Syed Dost , Zubair Talha , Anjum Usman
Published: March 2021

State-of-the-art advanced ultrasonic measurement through the Leaky-Lamb wave imaging technique (more commonly known as the flexural waveform analysis) was introduced nearly two decades ago to expand the envelope beyond which the classical pulse-echo evaluation operated. This technology has proven to be a game-changer in cement evaluation through provision of an integrated analysis which deconvolutes beyond the casing-cement interface and investigates further into the third interface. In this work, we integrate the cutting-edge analysis provided by ultrasonic flexural mode with the classical pulse-echo approach to yield a novel well-integrity evaluation blueprint. Subsequently, it is shown how this workflow is applied to an ultra-high pressure (UHP) exploratory well for integrity evaluation which will aid in future optimization of completion strategies and constitute a continuous improvement cycle for other wells. The subject well faced potential integrity related uncertainties due to fishing and cementing related issues.

A three-tier approach was adopted to develop the blueprint, starting off with problem identification with respect to the various operations and incidents that occurred on this well. Next, based on the anticipated problems, associated solutions to evaluate the same were investigated by considering the technologies and standard procedures practiced by the industry. Finally, based on the previous two steps, a multi-physics approach was adopted that makes use of a combination of pulse-echo and flexural ultrasonic analysis, in addition to multiple well integrity workflows. Consequently, combination of flexural attenuation and acoustic impedance allows for a comprehensive evaluation of the medium behind the casing through the Solid-Liquid-Gas map. Simultaneously, it is possible to quantify casing thickness and internal radius variations through pulse-echo amplitude and resonance frequency characterization. Furthermore, the Third-Interface-Echo analysis is conducted to determine annulus geometry descriptions and produce a unique in-situ casing centralization measurement.

The proposed well integrity blueprint contains various building blocks that are key to evaluation processes and provide a linkage-based approach to delineate potential problems. Accordingly, application of this blueprint illustrated the investigative approach it delivers with respect to cement barrier classification and casing condition assessment
Challenging Catenary Coiled Tubing Thru Tubing Screen Deployment Operation Offshore Borneo
Authors: Jong Seng Wei , Yong Yee Tzen , Azizan Yusri , Hampson Richard , Hj Abd Rani Rudzaifi Adizamri , Muhammad Khairul Amilin , Gurmin Ian
Published: March 2021

Production decline caused by sand ingress was observed on 2 offshore oil wells in Brunei waters. Both wells were completed with a sub-horizontal openhole gravel pack and were subsequently shut in as the produced sand would likely cause damage to the surface facilities.

In an offshore environment with limited workspace, crane capacity and wells with low reservoir pressures, it was decided to intervene the wells using a catenary coiled tubing (CT) vessel. The intervention required was to clean out the sand build up in the wells and install thru-tubing (TT) sand screens along the entire gravel packed screen section.

Nitrified clean out was necessary due to low reservoir pressures while using a specialized jetting nozzle to optimize turbulence and lift along the deviated section. In addition, a knockout pot was utilized to filter and accommodate the large quantity of sand returned.

The long sections of screens required could not be accommodated inside the PCE stack resulting in the need for the operation to be conducted as an open hole deployment using nippleless plug and fluid weight as well control barrier. A portable modular crane was also installed to assist the deployment of long screen sections prior to RIH with CT.

Further challenges that needed to be addressed were the emergency measures. As the operation was to be conducted using the catenary system, the requirement for an emergency disconnect between the vessel and platform during the long cleanout operations and open hole deployment needed to be considered as a necessary contingency. Additional shear seal BOPs, and emergency deployment bars were also prepared to ensure that the operation could be conducted safely and successfully.
Advance Live-Well Deployment System in Caspian Sea Wells
Authors: McClean C. , Parra D. , Piven A. , Rhahimov K. , Hadiaman F.
Published: March 2021

Over the past years the usage of coiled tubing as a prefer method to deploy long and heavy guns in highly deviated wells has been widely spread in the oil industry to provide a single run without killing the well, perforate in underbalance conditions, reduce risks and improve job efficiency. The three wells are located in the Caspian Sea. In two wells, the objective was to isolate lower intervals and perforate a new zone through tubing and casing between two packers. On the other well, the objective was to perforate a new interval through casing after running a new completion and isolate lower production zones.

Due to the challenges involving gross length of the new intervals, guns size, well deviation and live deployment needs several techniques were evaluated. The best approach was to use an Advance Live-Well Deployment (ALWD) system to deploy and retrieve the guns with a tube wire-enabled Coiled Tubing Telemetry (CTT) system focus on both safety and cost saving compare with conventional wireline perforating. Extensive job planning involved coiled tubing (CT) simulations to reach target depths, shock loading modeling to ensure forces are within CT string limitations, system integration test to verify deployment/reverse technique procedure and system communication to electrically activate guns.

CTT integrated sensor assembly was used during deployment/reverse operation with a tension, compression and torque (TCT) sub-assembly to monitor accurate upward/downward forces. In addition, CTT logging adapter assembly was used for depth correlation and electrical guns activation. The ALWD system; composed by connectors and deployment blow out preventor (BOP), prove to be an efficient way to run, perforate and retrieve gross intervals of 212 m, 246 m and 104 m with guns successfully. During all these jobs several lessons learnt were created in order to improve the deployment/reverse procedure for future jobs including not only operational steps but also deployment/reverse bottom-hole assembly (BHA) configurations.

Based on the success of these case histories, the ALWD combined with CTT system has been proven to be the preferred method when dealing with long perforation intervals in life well conditions, thru-tubing environment.
Case Study of Underbalance Coiled Tubing Drilling to Increase Well Productivity and Ultimate Recovery in Tight Gas Reservoir Onshore Field, Abu Dhabi
Authors: Ladmia Abdelhak , Culen Martin , Al Katheeri Abdulla Bakheet , Al Hosani Fahad Mustfa Ahmed , Edmonstone Graham F. J. , Mantilla Alfonso , Baslaib Mohamed Ahmed , Nabil Ihab Mohamed , Yousfi Fawad Zain , Al Hosani Mariam Ahmed , Almenhali Salem Saleh , El Shahat Ayman , Abdulsallam Fouad , Al-Khatib Haitham Mohamed , Al Jaberi Fawzi Omar , Al Beshr Huda , Mcneilly Kevin Dean
Published: March 2021

Coiled Tubing Drilling (CTD) has been growing and developed rapidly through the last two decades. There have been numerous highly successful applications of CTD technology in Alaska, Canada, Oman and the United Arab Emirates (Sharjah Sajaa and Dubai Murgham fields), among other places. Currently, Saudi Arabia has undertaken a campaign for the last seven years that has shown successful results in gas reservoirs.

ADNOC initiated a trial Coiled Tubing Underbalanced Drilling (CTUBD) project in the onshore tight gas reservoirs in Abu Dhabi, United Arab Emirates beginning operations 1-December-2019. The initial trial will consist of three (3) wells. The purpose of the trial is to assess the suitability of CTUBD for drilling the reservoir sections of wells in these fields, and further application in others.

The reason for choosing coiled tubing for drilling the reservoir sections is based upon the high H2S content of the reservoir fluids and the premise that HSE can be enhanced by using a closed drilling system rather than an open conventional system.

The three wells will be newly drilled, cased and cemented down to top reservoir by a conventional rig. The rig will run the completion and Christmas tree before moving off and allowing the coiled tubing rig to move onto the well. The coiled tubing BOPs will be rigged up on top of the Christmas tree and a drilling BHA will be deployed through the completion to drill the reservoir lateral.

The wells will be drilled underbalanced to aid reservoir performance and to allow hole cleaning with returns being taken up the coiled tubing / tubing annulus. The returns will be routed to a closed separation system with produced gas and condensate being primarily exported to the field plant via the production line, solids sparge to a closed tank or pit and the drilling fluid re-circulated. The primary drilling fluid will be treated water; however, nitrogen may be required for drilling future wells in the field and will be required regardless for purging gas from the surface equipment during operations. A flare will also be required for emergency use and for start-up of drilling. If the trial proves a success, a continuous drilling plan will be put in place.
Intervention Multi-Skilled Crew Reduces Personnel on Board, Footprint and Costs
Authors: Hillier Jill , Bruce Wayne , Arnold James , Delot Marc
Published: March 2021

This paper will highlight the advantages of multi-skilling intervention personnel on offshore installations. Crew members are from different service lines including Wireline, Slickline, Coiled Tubing and Gas Lift (completions). It will discuss how a multi-skilled crew is formed, specific scenarios on how they are utilized and how to develop and maintain the competencies of these personnel.

Through Multi-skilling personnel there is a potential to reduce crew sizes up to 50% for some standard intervention operations. Multi-skilling personnel during the 2020/2021 global pandemic has become critical as personnel movements across regions have become limited or nonexistent in some cases.

Reducing personnel on board has several benefits including lower personnel and logistics costs, lower carbon footprint of transportation of personnel, higher utilization of personnel, and motivating and retaining high skilled personnel as they learn new skills. It also allows for local personnel to be used for multiple operations permitting lower cost interventions to continue during a major global crisis.
Implementing Business Analytics Software to Optimize Coiled Tubing Operations: A Digital Approach to Operations Efficiency
Authors: Bautista Alarcon Xaymaca , Torres Carlos
Published: March 2021

This paper describes how business analytics novel software tools combined with advanced data management techniques can be integrated to management workflows and decision-making processes of a Coiled Tubing Service Company (CTSC).

An advanced data wrangling process (transforming and mapping data) was designed and implemented to unify current and historical coiled tubing operational data into a single data set. The latter was regularly updated with the latest operational information through an automated data querying process that eliminated the need for manually repeating the data wrangling. A Business Analytics Software (BAS) was used to accelerate the engineering of a Data Analytics (DA) process, identify correlations and trends, design data models, and create relevant Key Performance Indicators (KPI). Finally, BAS visualization tools were used to prepare and publish comprehensive cloud-based Business Intelligence (BI) dashboards and reports.

The BI dashboard allows the coiled tubing company to quickly perform accurate and efficient analysis of the KPI trends of its coiled tubing units and well interventions. The cloud-based Dashboard enables the CTSC to:

Effectively identify Coiled Tubing Strings utilization, costs, failures, vendors, and design performance trends based on factual data, thus enabling informed pipe management decisions. Clearly Identify high performance coiled tubing units and crews and make strategic decisions for high profile jobs. Identify equipment failures, non-productive time (NPT) trends and define, implement, and monitor maintenance and asset management strategies to tackle the failures with mayor impact on operations performance. Easily incorporate fresh operational data and detect record-breaking operations. Improve Customer Relationship Management by a quickly responding to customer inquiries for tailor-made operations performance reports. Decrease workload on repetitive processes by enabling reports generation with relevant and accurate data faster that previous methods in place. Quickly customize and create accurate documentation compiling relevant performance data in a consistent and standardized fashion. Perform well interventions technical analysis.

The contemporary approach to integrate BI Software to coiled tubing operations is a step change in how service companies and operators are analyzing and monitoring performance (efficiency, safety, and quality) to differentiate from each other, optimize results and minimize costs. This paper describes an example of a simple yet sophisticated and effective way of incorporating digital tools in the oilfield services processes by utilizing in house talent and resources.
RISK TRANSMISSION AND CONTROL OF PORT-HINTERLAND SERVICE NETWORK: FROM THE PERSPECTIVE OF PREVENTIVE INVESTMENT AND GOVERNMENT SUBSIDIES
Authors:   Collaborative Innovation Center for Transport Studies, Dalian Maritime University, Dalian 116026, China, Pengfei Zhang , Bing Han , Haibo Kuang ,   Shipping Economics and Management College, Dalian Maritime University, Dalian 116026 China,   Transportation Engineering College, Dalian Maritime University, Dalian 116026, China
Published: March 2021

The increase in risk prevention investments in the port-hinterland service network (PHSN) effectively enhances the network’s ability to resist risks and improve the sustainability and stability of ocean transportation. Based on the construction of the PHSN risk prevention investment utility model, the equilibrium strategy, the related characteristics of each participant in the complementary networks and the complete network are analyzed. Similarly, the subsidy policy of the government under the utility maximization of the whole service network is studied. We further propose new types of subsidy strategies based on the key nodes and key groups given the resources available and the subsidy efficiency constraints imposed, while also validating the advantages of this method based on a case analysis. The results indicate that the (1) equilibrium risk prevention investment is closely related to the Katz-Bonacich centrality, network interaction intensity, cost of unit risk prevention investment and competition intensity; (2) an undifferentiated subsidy strategy cannot improve the risk prevention effectiveness of the whole network; (3) the subsidy strategy based on key nodes and key groups effectively improves the risk prevention efficiency; and (4) the subsidy strategy of key groups is superior to the subsidy strategy of key nodes. Accordingly, the results of this study provide a reference for participants and managers in the PHSN when making risk prevention investment decisions.
INTERACTIVE MULTIMEDIA VALIDATION OF INTEGRATED NATURAL SCIENCE WITH THE THEME OF MOTION IN LIFE USING AN INTEGRATED SCIENTIFIC APPROACH TO 21ST CENTURY LEARNING
Authors:   Student Of Magister Degree Program Of Physics Education, UniversitasNegeri Padang Jl. Prof. Dr. Hamka Air Tawar Barat Padang-25131, Indonesia., Kurniawati Annisa , a Ratnawulan ,   Lecturer Of Master Degree Program Of Physics Education, UniversitasNegeri Padang, Jl. Prof Hamka Air Tawar Barat Padang-25131, Indonesia., Fauzi Ahmad ,   Lecturer Of Master Degree Program Of Physics Education, UniversitasNegeri Padang, Jl. Prof Hamka Air Tawar Barat Padang-25131, Indonesia.
Published: March 2021

Learning with interactive multimedia integrated natural science is expected to improve students 21st-century skills so that it can help students face the challenges of the 21st century.This study aims to determine the validation of the product developed, namely interactive multimedia integrated natural science with the theme of motion in life using an integrated scientific approach to 21st-century learning. Integrated natural science interactive multimedia is assessed from the aspects of the feasibility of content, constructs, graphics, and language. The validation was carried out by three validators. The instrument used was a validation instrument in the form of a questionnaire.The results of the research are interactive multimedia integrated natural science with the theme of motion in life using an integrated scientific approach to 21st century learning with valid criteria so that it can be used by educators in the natural science learning process in schools.
A CASE OF TRAUMATIC NEUROMA OF THE COMMON BILIARY DUCT SIMULATING A CHOLANGIOCARCINOMA
Authors:   Pathology Department, Mohammed VI university Hospital, Oujda., Najioui Younesse , Miry Achraf ,   Pathology Department, Mohammed VI university Hospital, Oujda., Mehdi Tiabi El. ,   Pathology Department, Mohammed VI university Hospital, Oujda., Malki Samia ,   Pathology Department, Mohammed VI university Hospital, Oujda., Haloui Anas ,   Pathology Department, Mohammed VI university Hospital, Oujda., Aissaoui Asmae ,   Pathology Department, Mohammed VI university Hospital, Oujda., Madani Ayoub ,   General Surgery Department, Mohammed VI University Hospital, Oujda., Abdelouaheb Hajar ,   Radiology Department, Mohammed VI University Hospital, Oujda., Bouziane Mohammed ,   General Surgery Department, Mohammed VI University Hospital, Oujda., Kamaoui Imane ,   Radiology Department, Mohammed VI University Hospital, Oujda., Bennani Amal ,   Pathology Department, Mohammed VI university Hospital, Oujda.
Published: March 2021

We present a case of traumatic neuroma of the common bile duct in a 53-year-old woman who presented with jaundice,5months after cholecystectomy. Physical examination revealed jaundice, epigastric pain and scratching lesions. Gamma glutamyl transferase (GGT) at 109 U/L, Alkaline phosphatase at 175U/L. CA19-9 was at 500U/mlMagnetic resonance cholangiopancreatography revealed a T1 and T2hyperintense lesion of peri-hilar fat. An increase in intensity was noted after useof gadolinium.Exploratory laparotomy was performed with the presumptive diagnosis of cholangiocarcinoma. Pathologic analysis of the surgical specimen revealed Haphazard mature nerves, consistent with a bile duct neuroma. Follow-up of the patient showed no post-operative complications or signs of recurrence.
SOCIAL JUSTICE AMONG ELDERLY ADULTS WITH DISABILITY: IMPLICATION FOR ACCESS TO SOCIAL BENEFITS
Authors: Wumpini Osman Shamrock
Published: March 2021

Late-life has traditionally been regarded as a time for relaxation and reflection upon the time spent in life. However, this experience is often not the case for older adults in developing countries. Despite the growing numbers of older adults and efforts to support this population, there continue to be significant setbacks emerging from a lack of policy sensitivity and numerous implementation challenges, especially for older adults with physical disabilities who seek to access social benefits. Many older adults with disabilities continue to experience diverse social, cultural, and economic challenges spanning from financial insecurity, social isolation, mental and physical health needs, and elder abuse. These challenges, confounded with the presence of a disability, may result in older adults taking up laboured activities, such as street begging in urban environments around the country or engage in subsistence farming as a coping mechanism to challenges they face in late-life. This paper looks into the characteristics of older adults Ghana and policies that affect their access to social benefits. Recommendations in this paper include a call for the Government of Ghana to revise the retirement age from 60 to 65 years and focus on challenges associated with reports of corrupt practices among appointees in the distribution of disability funds through local government structures. Keywords: Disability, older adults, Ghana, social benefits, retirement.
DETECÇÃO E QUANTIFICAÇÃO DE NANOPARTÍCULAS DE PRATA POR SPICP-MS
Authors: Bazilio Fabio , Silva Cristiane , Santos Lísia , Vicentini Santos , Jacob Silvana , Abrantes Shirley
Published: March 2021

DETECTION AND QUANTIFICATION OF SILVER NANOPARTICLES BY spICP-MS. The growing interest in nanotechnology has led to an increase in the production and application of nanoparticles worldwide. Due to the unique functional properties of nanoparticles, these materials are being used by many industries, including the agricultural and food sectors. Among the commercially available nanomaterials, it is possible to highlight those produced with silver nanoparticles. One of the most promising techniques for the analysis of metallic nanoparticles is the Inductively coupled plasma mass spectrometry (ICP-MS) performed in single particle mode (spICP-MS). However, the use of the technique in the detection and measurement of nanoparticles requires that the equipment be operated differently than when used to analyze dissolved metal solutions. Thus, this article presents the use of the spICP-MS technique for the measurement and quantification of nanoparticles, as well as their validation. The method proved to be adequate for the purpose, presenting a satisfactory result for the selectivity test and recovery of 83.7 (40 nm) and 77.6% (80 nm). The detection limits, determined for the most frequent size, dissolved silver concentration and particle concentration, were 17.5 nm, 0.736 ng mL-1,146 particles mL-1, respectively. Thus, the results obtained indicated the possibility of using the technique to determine the size and concentration of silver nanoparticles.
Quercetin: A Potential Candidate for the Treatment of Arthritis
Authors: Goyal Ahsas , Agrawal Neetu
Published: March 2021

:

Diet plays a significant role in ensuring healthy life and the bioactive compounds present in food and medicinal plants may be developed as drugs that combat various illnesses. A bioactive flavanoid, quercetin which is a dietary component possesses numerous health-promoting effects. In preclinical models of rheumatoid arthritis, gouty arthritis and osteoarthritis, quercetin has shown significant joint protective effects. Taking into account the significance of this compound, the present review discusses its anti-arthritic properties, demonstrating its mechanism of action for the treatment of arthritis with its therapeutic potential.
Large-scale Prediction of Drug-Protein Interactions Based on Network
Information
Authors: Li Xinsheng , Ma Daichuan , Ren Yan , Luo Jiesi , Li Yizhou
Published: March 2021

Background:

The prediction of drug-protein interaction (DPI) plays an important role in drug
discovery and repositioning. Unfortunately, traditional experimental validation of DPIs is expensive and
time-consuming. Therefore, it is necessary to develop in silico methods for the identification of potential
DPIs.

Method:

In this work, the identification of DPIs was performed by the generated recommendation of the
unexplored interaction of the drug-protein bipartite graph. Three kinds of recommenders were proposed to
predict the potential DPIs.

Results:

The simulation results showed that the proposed models obtained good performance in crossvalidation
and independent test.

Conclusion:

Our recommendation strategy based on collaborative filtering can effectively improve the
DPI identification performance, especially for certain DPIs lacking chemical structure similarity or genomic
sequence similarity.
Time-Domain Signal Reconstruction of Vehicle Interior Noise Based on
Data-Driven Method
Authors: Cao Jiaqi , Wang Xiaolan , Wang Yansong , Li Zhuo , Yang Dongpo
Published: March 2021

Background:

In the process of high-speed driving, there are many source signals that affect the ear noise of passengers in the car. It is important to obtain the reference signal of Active Noise Control (ANC) of the vehicle at high speed condition.

Objective:

This paper introduces a method to study the time-domain signal reconstruction of interior noise based on data-driven method.

Methods:

Based on the noise signal collected in a car, the key point signals affecting the interior noise are determined by the acoustic transfer path analysis method. Considering the time-varying characteristics of the noise signal and the complex nonlinear relationship of interior noise, a noise reconstruction model based on wavelet decomposition Radial Basis Function (RBF) neural network is established. And the BP neural network noise reconstruction model is set up to compare the reconstruction effect.

Results:

According to the reconstruction comparison, the average absolute error (0.0072) of the proposed algorithm model is smaller than the average absolute error of the noise reconstruction BP network model based on wavelet decomposition (0.0280), and the accuracy is improved by 74.29%. The average absolute error between the reconstructed value of RBF neural network and the real-value is smaller than that of BP neural network, and the error of the proposed model is less than 0.01. The method proposed in this paper can reconstruct the interior noise signal of vehicle accurately and effectively.

Conclusion:

This paper proposes a reconstruction model of vehicle interior noise signal based on wavelet decomposition RBF neural network algorithm driven by data-driven, and verifies the effectiveness of the algorithm with the real vehicle test data. The reconstruction method of RBF neural network based on data-driven wavelet decomposition provides a certain reference value for ANC to obtain high-precision reference signal.
Littérature Orale et Société. La Chanson 'Attention au SIDA' et la Vie Sociale en RD Congo
Authors: Mbwangi Mbwangi Julien
Published: March 2021

La littérature est bel et bien un essai de construction d’un monde idéal. Ainsi, tout texte littéraire, quelle que soit sa nature est en miniature une construction mentale dans laquelle le réel est perçu comme palimpseste de l’imaginaire. Dans ce sens, les écrivains, les artistes, les musiciens ont une responsabilité face aux événements qui affectent leur environnement. Par leur esprit de projection, ils ont le pouvoir d’orienter le cours des événements. Luambo Makiadi Franco dont nous avons ana- lysé le texte est un exemple d’un auteur sensible qui, par son art, a donné une orientation objective devant un problème social. La littérature de ce point de vue constitue une loupe pour bien voir la société et l‘orienter.

MOTS CLÉS: LITTÉRATURE ORALE, SOCIÉTÉ, VIE SOCIALE, RESPONSABILITÉ, CONSTRUCTION, DÉCONSTRUCTION.

Literature is a construct that tests the possibilities of an ideal world. Thus, any literary text, whatever its nature, is in miniature a mental construct in which reality is perceived as a palimpsest of the imagination. In this way writers, artists and musicians have a responsibility to treat events that affect their environment. With their talent of projection, they have the power to direct the course of events. Luambo Makiadi Franco, whose text is the subject of analysis in this paper, is an example of a sensitive author, whose art has given us an intersubjective understanding of a social problem. In this type of work, literature is a magnifying glass through which society is examined and guided in a particular direction.

KEY WORDS : ORAL LITERATURE, SOCIETY, SOCIAL LIVE, RESPONSIBILITY, CONSTRUCTION, DECONSTRUCTION.
COVID-19 Lockdown in Wuhan: Heart Rate Variability in Females and Males – A Pilot Study
Authors:   Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine, Research Unit for Complementary and Integrative Laser Medicine, and Traditional Chinese Medicine (TCM) Research Center Graz, Medical University of Graz, 8036 Graz, Austria, Litscher Gerhard , Li Tong , Liang Fengxia
Published: March 2021

In a pioneer transcontinental pilot study conducted with 50 volunteers, it was revealed that women could have apparently overcome the world's toughest lockdown in terms of changes in the general state of health measured using the heart rate variability parameter better than men. The results of the present study obtained in Wuhan provide information on the initial trend in this regard.
Competitividad de la fresa mexicana en el mercado estadounidense de 1992 a 2017
Authors: Arroyo Cossio Arturo Julian , Hernández Flores Alondra Alejandra
Published: March 2021

Las exportaciones de fresa a nivel internacional han alcanzado un promedio de 457.703 t en los últimos 30 años; el 2012 fue el año más importante con 852.369 t exportadas en total. Para el 2013, el valor de estas exportaciones fue de USD 2.330.136, y entre 1983 y 2013, el promedio fue de USD 971.262. La producción de fresa en México ha incrementado debido a programas enfocados en el fomento de la agricultura y la aplicación de métodos de producción. En 2011, los mayores exportadores de fresa fueron España, EE. UU., Países Bajos, Bélgica y México. El principal destino de exportación fue EE. UU., que concentró el 96 % para complementar su demanda. Los datos de producción y exportación ubican a México en el segundo lugar de producción y el quinto lugar de exportación a nivel mundial. Este estudio tuvo por objetivo determinar la competitividad de la fresa mexicana en el mercado estadounidense y su comportamiento en comparación con otros países exportadores como España y EE. UU. Para medir la competitividad, se utilizó el índice de Balassa y el índice de grado de apertura en exportaciones, que señalaron una competitividad positiva. Sin embargo, se requiere mayor especialización para aumentar los niveles competitivos existentes.
HOPES: An Integrative Digital Phenotyping Platform for Data Collection, Monitoring, and Machine Learning
Authors: Wang Xuancong , Vouk Nikola , Heaukulani Creighton , Buddhika Thisum , Martanto Wijaya , Lee Jimmy , Morris Robert JT
Published: March 2021

The collection of data from a personal digital device to characterize current health conditions and behaviors that determine how an individual’s health will evolve has been called digital phenotyping. In this paper, we describe the development of and early experiences with a comprehensive digital phenotyping platform: Health Outcomes through Positive Engagement and Self-Empowerment (HOPES). HOPES is based on the open-source Beiwe platform but adds a wider range of data collection, including the integration of wearable devices and further sensor collection from smartphones. Requirements were partly derived from a concurrent clinical trial for schizophrenia that required the development of significant capabilities in HOPES for security, privacy, ease of use, and scalability, based on a careful combination of public cloud and on-premises operation. We describe new data pipelines to clean, process, present, and analyze data. This includes a set of dashboards customized to the needs of research study operations and clinical care. A test use case for HOPES was described by analyzing the digital behavior of 22 participants during the SARS-CoV-2 pandemic.
A Natural Language Processing–Based Virtual Patient Simulator and Intelligent Tutoring System for the Clinical Diagnostic Process: Simulator Development and Case Study
Authors: Furlan Raffaello , Gatti Mauro , Menè Roberto , Shiffer Dana , Marchiori Chiara , Giaj Levra Alessandro , Saturnino Vincenzo , Brunetta Enrico , Dipaola Franca
Published: March 2021

Background

Shortage of human resources, increasing educational costs, and the need to keep social distances in response to the COVID-19 worldwide outbreak have prompted the necessity of clinical training methods designed for distance learning. Virtual patient simulators (VPSs) may partially meet these needs. Natural language processing (NLP) and intelligent tutoring systems (ITSs) may further enhance the educational impact of these simulators.

Objective

The goal of this study was to develop a VPS for clinical diagnostic reasoning that integrates interaction in natural language and an ITS. We also aimed to provide preliminary results of a short-term learning test administered on undergraduate students after use of the simulator.

Methods

We trained a Siamese long short-term memory network for anamnesis and NLP algorithms combined with Systematized Nomenclature of Medicine (SNOMED) ontology for diagnostic hypothesis generation. The ITS was structured on the concepts of knowledge, assessment, and learner models. To assess short-term learning changes, 15 undergraduate medical students underwent two identical tests, composed of multiple-choice questions, before and after performing a simulation by the virtual simulator. The test was made up of 22 questions; 11 of these were core questions that were specifically designed to evaluate clinical knowledge related to the simulated case.

Results

We developed a VPS called Hepius that allows students to gather clinical information from the patient’s medical history, physical exam, and investigations and allows them to formulate a differential diagnosis by using natural language. Hepius is also an ITS that provides real-time step-by-step feedback to the student and suggests specific topics the student has to review to fill in potential knowledge gaps. Results from the short-term learning test showed an increase in both mean test score (P<.001) and mean score for core questions (P<.001) when comparing presimulation and postsimulation performance.

Conclusions

By combining ITS and NLP technologies, Hepius may provide medical undergraduate students with a learning tool for training them in diagnostic reasoning. This may be particularly useful in a setting where students have restricted access to clinical wards, as is happening during the COVID-19 pandemic in many countries worldwide.
An App-Based Parenting Program to Promote Healthy Energy Balance–Related Parenting Practices to Prevent Childhood Obesity: Protocol Using the Intervention Mapping Framework
Authors: Karssen Levie T , Vink Jacqueline M , de Weerth Carolina , Hermans Roel C J , de Kort Carina P M , Kremers Stef PJ , Ruiter Emilie L M , Larsen Junilla K
Published: March 2021

Background

The family environment plays an important role in the development of children’s energy balance–related behaviors. As a result, parents’ energy balance–related parenting practices are important targets of preventive childhood obesity programs. Families with a lower socioeconomic position (SEP) may benefit from participating in such programs but are generally less well reached than families with a higher SEP.

Objective

This paper describes the application of the Intervention Mapping Protocol (IMP) for the development of an app-based preventive intervention program to promote healthy energy balance–related parenting practices among parents of children (aged 0-4 years) with a lower SEP.

Methods

The 6 steps of the IMP were used as a theory- and evidence-based framework to guide the development of an app-based preventive intervention program.

Results

In step 1, behavioral outcomes for the app-based program (ie, children have a healthy dietary intake, sufficient sleep, and restricted screen time and sufficient physical activity) and sociocognitive (ie, knowledge, attitudes, and self-efficacy) and automatic (ie, habitual behaviors) determinants of energy balance–related parenting were identified through a needs assessment. In step 2, the behavioral outcomes were translated into performance objectives. To influence these objectives, in step 3, theory-based intervention methods were selected for each of the determinants. In step 4, the knowledge derived from the previous steps allowed for the development of the app-based program Samen Happie! through a process of continuous cocreation with parents and health professionals. In step 5, community health services were identified as potential adopters for the app. Finally, in step 6, 2 randomized controlled trials were designed to evaluate the process and effects of the app among Dutch parents of infants (trial 1) and preschoolers (trial 2). These trials were completed in November 2019 (trial 1) and February 2020 (trial 2).

Conclusions

The IMP allowed for the effective development of the app-based parenting program Samen Happie! to promote healthy energy balance–related parenting practices among parents of infants and preschoolers. Through the integration of theory, empirical evidence, and data from the target population, as well as the process of continued cocreation, the program specifically addresses parents with a lower SEP. This increases the potential of the program to prevent the development of obesity in early childhood among families with a lower SEP.

Trial Registration

Netherlands Trial Register NL6727, https://www.trialregister.nl/trial/6727; Netherlands Trial Register NL7371, https://www.trialregister.nl/trial/7371.
An mHealth App (Speech Banana) for Auditory Training: App Design and Development Study (Preprint)
Authors: Ratnanather J Tilak , Bhattacharya Rohit , Heston Margo B , Song Joanne , Fernandez Lindsey R , Lim Hong Seo , Lee Seung-Wook , Tam Edric , Yoo Sungho , Bae Seung-Ho , Lam Inez , Jeon Hyoung Won , Chang Son A , Koo Ja-Won
Published: March 2021

BACKGROUND

With the growing adult population using electronic hearing devices such as cochlear implants or hearing aids, there is an increasing worldwide need for auditory training (AT) to promote optimal device use. However, financial resources and scheduling conflicts make clinical AT infeasible.

OBJECTIVE

To address this gap between need and accessibility, we primarily aimed to develop a mobile health (mHealth) app called Speech Banana for AT. The app would be substantially more affordable and portable than clinical AT; would deliver a validated training model that is reflective of modern techniques; and would track users’ progress in speech comprehension, providing greater continuity between periodic in-person visits. To improve international availability, our secondary aim was to implement the English language training model into Korean as a proof of concept for worldwide usability.

METHODS

A problem- and objective-centered Design Science Research Methodology approach was adopted to develop the Speech Banana app. A review of previous literature and computer-based learning programs outlined current AT gaps, whereas interviews with speech pathologists and users clarified the features that were addressed in the app. Past and present users were invited to evaluate the app via community forums and the System Usability Scale.

RESULTS

Speech Banana has been implemented in English and Korean languages for iPad and web use. The app comprises 38 lessons, which include analytic exercises pairing visual and auditory stimuli, and synthetic quizzes presenting auditory stimuli only. During quizzes, users type the sentence heard, and the app provides visual feedback on performance. Users may select a male or female speaker and the volume of background noise, allowing for training with a range of frequencies and signal-to-noise ratios. There were more than 3200 downloads of the English iPad app and almost 100 downloads of the Korean app; more than 100 users registered for the web apps. The English app received a System Usability Scale rating of “good” from 6 users, and the Korean app received a rating of “OK” from 16 users.

CONCLUSIONS

Speech Banana offers AT accessibility with a validated curriculum, allowing users to develop speech comprehension skills with the aid of a mobile device. This mHealth app holds potential as a supplement to clinical AT, particularly in this era of global telemedicine.