bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic detection of mosaicism by using digital NGS reveals three new MEN1 mosaicisms
Authors: Lagarde Arnaud , Mougel Grégory , Coppin Lucie , Haissaguerre Magalie , Le Collen Lauriane , Mohamed Amira , Klein Marc , Odou Marie-Françoise , Tabarin Antoine , Brixi Hedia , Cuny Thomas , Delemer Brigitte , Barlier Anne , Romanet Pauline
Published: September 2022

Purpose

Mosaicism is a feature of several inherited tumor syndromes. Only a few cases of mosaicism have been described in multiple endocrine neoplasia type 1 (MEN1). Next-generation sequencing (NGS) offers new possibilities for detecting mosaicism. Here, we report the first study to systematically look for MEN1 mosaicism, using blood DNA, in MEN1-suspected patients but without MEN1 pathogenic variants (PV) in a heterozygous state.

Methods

Digital targeted NGS, including unique molecular identifiers (UMIs), was performed in routine practice, and the analytic performance of this method was verified.

Results

Among a cohort of 119 patients harboring from 2 to 5 MEN1 lesions, we identified 3 patients with MEN1 mosaic PVs. The allele frequencies ranged from 2.3 to 9.5%. The detection rate of MEN1 mosaicism in patients bearing at least 3 MEN1 lesions was 17% (3/18). No cases were detected in patients with two lesions.

Conclusion

We report here three new cases with MEN1 mosaicism. This study examined the performance of UMI in the diagnosis of MEN1 mosaicism in routine practice, and our results underline that the frequency of mosaicism is probably underestimated in patients with suspected MEN1.
Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia
Authors: Rytkönen Kalle T , Adossa Nigatu , Mahmoudian Mehrad , Lönnberg Tapio , Poutanen Matti , Elo Laura L
Published: September 2022

In brief

Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia.

Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.
Effect of integration method and carbonization temperature on the performance of an integrated hydrothermal carbonization and CHP plant
Authors: Saari Jussi , Kuparinen Katja , Sermyagina Ekaterina , Vakkilainen Esa , Kaikko Juha , Sergeev Vitaly
Published: September 2022

Wood-fired small- and medium-scale combined heat and power (CHP) plants are a proven technology for producing domestic, carbon-neutral heat and power. Hydrothermal carbonization (HTC) is a promising conversion technology for producing an improved, more versatile wood fuel. By integrating the HTC and CHP processes, the HTC process can be notably simplified. This study compares six different integration schemes to non-integrated plants. The overall energy conversion efficiencies were similar in all six schemes, but there were differences in power output and in plant complexity, and thus likely differences in investment cost and operability. The most promising cases were evaluated at varying HTC temperatures. This comparison showed that temperatures over 220 °C became problematic for the simpler heat recovery schemes, which resulted in poor efficiencies.
ZnCl2 pretreatment of bamboo chips to produce chemi-thermomechanical pulp: Saving refining energy and improving pulp properties
Authors: Hu Zhijun , Musikavanhu Brian , Li Jing , Lin Jiang , He Zhibin
Published: September 2022

The pretreatment of biomass materials is critical for improvement of the overall production process and product quality. In this work, a dilute zinc chloride (ZnCl2) solution was used to pretreat bamboo chips, followed by defiberization (mechanical pulping). Compared to the results from the traditional chemi-thermomechanical pulping process, the results from this study showed that the refining energy consumption of the modified process was lowered 27%, and the tensile and burst index of the resultant pulp increased 22% and 82%, respectively. The morphological changes on the fiber surface, functional groups, and crystallinity of resultant pulps due to the ZnCl2 treatment were also analyzed.
Degumming crude enzyme produced by Bacillus cereus HDYM-02 and its application in flax retting
Authors: Zhao Dan , Pan Chao , Ping Wenxiang , Ge Jingping
Published: September 2022

A cellulase-free, degumming crude enzyme was produced by Bacillus cereus HDYM-02, using konjaku flour as an inexpensive substrate. After 48 h fermentation, this crude enzyme consisted of pectinase and mannanase, whose maximum activity was 756.7 U/mL and 2967.3 U/mL, respectively. This crude enzyme exhibited considerable stability under the conditions resembling industrial flax retting. After 120 h incubation, more than 50% of the maximum activity of both pectinase and mannanase was retained at pH value 4.0 to 7.0, and at least 70% of the maximum activity was detected at 25 °C to 40 °C. The degumming liquid retted by this crude enzyme contained more galacturonic acid and reducing sugar than those in the degumming liquid retted by commercial pectinase. The application of B. cereus HDYM-02 crude enzyme resulted in higher weight loss of flax stems, better properties, higher productivities, and smoother surfaces of flax fibres. This study showed promise for the use of B. cereus HDYM-02 crude enzyme for flax retting in the textile industry.
Features of social and legal protection of employees on labor platforms and directions of formation of regulatory policy of Ukraine under conditions of martial law
Authors:   Institute of Industrial Economics of NAS of Ukraine, Pankova Oksana , Kasperovich Olexandr ,   Institute of Industrial Economics of NAS of Ukraine
Published: September 2022

The article explores and reveals the problems and opportunities for creating an effective system of social and legal protection of workers in the platform segment of employment in Ukraine, grounding on the analysis and generalization of results of the expert survey, in the preparation and conduct of which the authors were directly involved. The conditions of the military conflict and the needs of postwar reconstruction of Ukraine are also taken into account. The main reasons hindering the legal and social protection of platform workers are identified. The key ones among them are the following: legal uncertainty of the status of subjects of labor platforms (both platform workers and labor platforms themselves); low opportunities for collective representation of the interests of employees on the platforms; reluctance of employees to officially register and declare their income. Also, a set of factors of a social, informational, communicative, organizational, managerial and technical nature was revealed. These factors arise in the process of interaction of the subjects of the platform economy and increase the social and legal insecurity of the platform employees. The obtained results were interpreted by the authors in the context of the martial law in Ukraine. It is stated that the basic prerequisite for the development of an effective system of social and legal protection of platform employees is the creation of a legally regulated system of interaction between subjects of the platform economy, which requires appropriate regulatory, organizational and management support, formalization and exit from the "shadow" of relationships on labor platforms, implementation of mechanisms of sustainable representation of interests of the subjects of the platform economy. The vision of the main characteristics of the effective system of ensuring the legal and social protection of platform workers and priority of key measures to ensure the effectiveness of their social protection process are substantiated. Basing on the generalization of the results of the research conducted, the authors have developed a scheme of conceptualization of the regulatory policy development process, which is focused on the possibility of ensuring the social and legal protection of platform workers. The authors' proposals are consistent with the main guidelines of the proposals for Directive on improving the working conditions in platform work for EU. The authors also defined and substantiated the priority areas of regulatory policy in the context of mitigating the impact of martial law on the labor market and of the prospects for further post-war restoration of Ukraine.
Prognosis of Children Undergoing Liver Transplantation: A 30-Year European Study
Authors: Baumann Ulrich , Karam Vincent , Adam René , Fondevila Constantino , Dhawan Anil , Sokal Etienne , Jacquemin Emmanuel , Kelly Deirdre A. , Grabhorn Enke , Pawlowska Joanna , D’Antiga Lorenzo , Jara Vega Paloma , Debray Dominique , Polak Wojciech G. , de Ville de Goyet Jean , Verkade Henkjan J. ,   European Liver and Intestine Transplant Association (ELITA) and all ELTR contributing centers
Published: September 2022

OBJECTIVES

The European Liver Transplant Registry has been collecting data on virtually all pediatric liver transplant (PLT) procedures in Europe since 1968. We analyzed patient outcome over time and identified parameters associated with long-term patient outcome.

METHODS

Participating centers and European organ-sharing organizations provided retrospective data to the European Liver Transplant Registry. To identify trends, data were grouped into consecutive time spans: era A: before 2000, era B: 2000 to 2009, and the current era, era C: since 2010.

RESULTS

From June 1968 until December 2017, 16 641 PLT were performed on 14 515 children by 133 centers. The children <7 years of age represented 58% in era A, and 66% in the current era (P <.01). The main indications for PLT were congenital biliary diseases (44%) and metabolic diseases (18%). Patient survival at 5 years is currently 86% overall and 97% in children who survive the first year after PLT. The survival rate has improved from 74% in era A to 83% in era B and 85% in era C (P <.0001). Low-volume centers (<5 PLT/year) represented 75% of centers but performed only 19% of PLT and were associated with a decreased survival rate. In the current era, however, survival rates has become irrespective of volume. Infection is the leading cause of death (4.1%), followed by primary nonfunction of the graft (1.4%).

CONCLUSIONS

PLT has become a highly successful medical treatment that should be considered for all children with end-stage liver disease. The main challenge for further improving the prognosis remains the early postoperative period.
Association between prehospital recognition of acute myocardial infarction and length of stay in the emergency department
Authors: Song So Ra , Kim Ki Hong , Park Jeong Ho , Song Kyoung Jun , Shin Sang Do
Published: September 2022

Objective This study aimed to evaluate the association between prehospital recognition of acute myocardial infarction (AMI) and length of stay (LOS) in the emergency department (ED) of emergency medical service (EMS)-transported AMI patients.Methods A multicenter retrospective observational study was conducted using prehospital and hospital data from three tertiary emergency departments. Patients diagnosed with AMI between January 2015 and December 2018 were enrolled. Study groups were categorized according to prehospital recognition and prehospital 12-lead electrocardiography (ECG) into three groups based on an EMS cardiovascular registry: group A, no prehospital recognition (reference group); group B, prehospital recognition without 12-lead ECG; and group C, prehospital recognition with 12-lead ECG. The primary outcome was an ED LOS of less than 4 hours.Results Among 1,237 study participants, 722 (58.4%) were in group A, 325 (26.3%) were in group B, and 190 (15.4%) were in group C. Multivariable logistic regression showed that groups B and C had a higher likelihood of a short ED LOS (adjusted odds ratio [95% confidence interval]: group B, 1.64 [1.21–2.22] and group C, 1.88 [1.30–2.71]) than group A. There was no significant difference in ED LOS according to whether prehospital 12-lead ECG was conducted.Conclusion Prehospital recognition of AMI by EMS personnel, with or without 12-lead ECG, was associated with a short ED LOS.
Educadoras na educação infantil
Authors: Ferrari Andrea Gabriela , Couto Marcela Graef do , Kessler Júlia Avila , Silva Milena da Rosa
Published: September 2022

Este escrito é um desdobramento de um projeto de pesquisa-extensão desenvolvido pelo Núcleo de Estudos em Psicanálise e Infâncias (NEPIs) junto a berçários de escolas de educação infantil municipais e conveniadas de Porto Alegre. A partir dessa experiência, tomamos como questão o trabalho de educação-cuidado desenvolvido nas instituições de educação infantil e alguns atravessamentos de gênero, raça e classe que marcam essa profissão no Brasil. Para tanto, por meio de uma revisão narrativa de literatura, traçamos uma breve retomada histórica acerca da constituição da educação infantil nos contextos europeu e brasileiro e apresentamos trechos dos diários clínicos – materiais de registro adotados pelas pesquisadoras –extensionistas – que se articulam às questões discutidas. A partir desse processo de escrita, mostrou-se evidente a importância de considerar o trabalho das educadoras das escolas de educação infantil como uma confluência de aspectos históricos e sociais e como um panorama interseccional, permeado por atravessamentos de gênero, raça e classe, e por processos de desvalorização de diversas ordens.
corpo constituinte no pensamento sartriano?
Authors: Souza Thana Mara de
Published: September 2022

Pretende-se, neste artigo, compreender o que é uma conduta emotiva para Jean-Paul Sartre, a partir de Esboço de uma Teoria das Emoções. Para tanto, será necessário descrever as diferenças entre os modos pragmático e mágico de ser-no-mundo, dado que a emoção se constitui como crença no aspecto mágico. Esta noção de crença, na medida em que se localiza no corpo, exige, por sua vez, uma discussão sobre o papel do corpo e sua relação com a consciência. Veremos que, embora com oscilações e sem desenvolvê-la, Sartre abre a perspectiva de pensar a relação consciência-corpo como totalidade sintética, a qual se manterá como fundamental em sua filosofia.
Examining Progress Toward Elimination of Racial and Ethnic Health Disparities for Healthy People 2020 Objectives Using Three Measures of Overall Disparity
Authors: Huang David , Bassig Bryan , Hubbard Kate , Klein Richard , Talih Makram
Published: September 2022

This report examines changes in health disparities over time by race and ethnicity for HP2020 objectives using three measures of disparity.
Diversidade e diferença: desafios para a formação dos profissionais de saúde
Authors: Machin Rosana , Paulino Danilo Borges , Pontes Júlia Clara de , Rodrigues Raphaela Rezende Nogueira
Published: September 2022

Resumo O artigo tem como objetivo discutir a questão da diversidade a partir da sua incorporação na formação dos profissionais de saúde por meio da análise das Diretrizes Curriculares Nacionais (DCN) de dois cursos de graduação na área da saúde no Brasil: medicina e psicologia. Para isso, problematiza a questão da diversidade a partir da contribuição das ciências sociais, ao considerar as múltiplas noções presentes na natureza das diferenças sociais e culturais, rompendo com conceitos essencialistas de diferença. Reflete-se sobre como a diversidade está presente nas diretrizes curriculares desses cursos e, a partir de trabalhos recentes, analisa-se como a diversidade tem sido contemplada na formação, bem como os principais desafios colocados. A interseccionalidade é considerada um referencial teórico político importante para apreender a articulação de múltiplas diferenças e desigualdades que atuam de forma dinâmica, fluida e flexível a partir de contextos históricos particulares, sendo nesse sentido sensível para abordar a questão da diversidade na formação dos profissionais de saúde. Destaca-se a importância de realizar uma análise das diferenças, sugerindo um quadro analítico que articule discursos e práticas, formas de subjetivação e relações sociais.
Grammars of ableism: dialogues in the folds between disability, gender, childhood, and adolescence
Authors: Moreira Martha Cristina Nunes , Dias Francine de Souza , Mello Anahi Guedes de , York Sara Wagner
Published: September 2022

Abstract In this theoretical essay, we assume ableism as a grammar that sustains several duplicities that hierarchize and discriminate reputed dissident corporalities. We maintain this argument based on the violation of rights to health and life of disabled people, travestis, trans and intersex people, and children and adolescents, in practices of surveillance and correction, which sustain health and education institutions, and Language as the central point of such enabling.
“But the category of exposure also has to respect identity”: MSM, classifications and disputes in AIDS policy
Authors: Calazans Gabriela , Facchini Regina
Published: September 2022

Abstract This essay explores the relationship between diversity and public health by addressing tensions related to classifications and recognition in the field of HIV and AIDS policy. The objective is to reflect on how classificatory and operative categories are articulated within the scope of programmatic responses towards the social production of differences and inequalities. To do so it draws from the theoretical framework of studies on vulnerability and recognition and from a methodology that includes a critical review of the literature on the category men who have sex with men (MSM) and ethnographic material, derived from the authors’ research and a literature review related to social movements, and research and policies focused on lesbians, gays, bisexuals, transvestites and transsexuals (LGBT). It reviews how the MSM category was constructed in the field of HIV and AIDS prevention policies at an international level, situating political actors and tensions. It problematizes these tensions by analyzing processes of production of political subjects as well as changes in socio-state relations that involve LGBT. It emphasizes the importance of considering how differences and inequalities emerge in socio-political processes and of dedicating studies to improve policies, ensuring an effectively more respectful care.
Filling out the race/skin color item in the patient identification form: aspects of its implementation in a university hospital
Authors: Geraldo Rafael Marques , Oliveira Júlio César de , Alexandre Larissa Sousa Cardoso , Aguiar Marília Ribeiro de Azevedo , Vieira Abna Faustina Sousa , Germani Ana Claudia Camargo Gonçalves
Published: September 2022

Abstract Thirteen years after the publication of the National Policy for the Comprehensive Health of the Black Population (PNSIPN, Política Nacional da Saúde Integral da População Negra), filling out the race/skin color question in the patient identification form remains a challenge. Authors have focused on the need to integrate knowledge from the science of implementation into public policies. The aim of this article is to describe and analyze the implementation of the collection of the race/skin color item carried out by the professionals responsible for the registration of patients at a university hospital in the city of São Paulo. This was an exploratory and descriptive study, structured from three constructs of the Consolidated Framework for Implementation Research (CFIR): intervention, internal scenario and characteristics of individuals. Most records of race/skin color in the observed institution are made by heteroidentification. Based on the CFIR constructs, aspects identified as obstacles and facilitators are identified. The implementation of the collection of the race/skin color item by self-declaration, as provided for in the PNSIPN and in Ordinance n. 344/2017, is still incipient and depends mainly on organizational changes, which can favor its effectiveness.
E se Dona Violeta fosse uma mulher negra? Reflexões a partir de “O cuidado, os modos de ser (do) humano e as práticas de saúde”
Authors: Borret Rita Helena do Espírito Santo
Published: September 2022

Resumo É possível discutir humanização em saúde sem dar centralidade para as expressões do racismo nos processos de adoecimento? Seria possível pensar práticas humanizadas de cuidado sem considerar o racismo estrutural e institucional na saúde? Uma resposta afirmativa para uma dessas perguntas reforça o vigente mito da democracia racial brasileira, que nos impede de reconhecer ou validar o quanto o racismo está presente em nossa sociedade e produz experiências desiguais de viver, adoecer e morrer para a população negra, que contabiliza mais de 56% da população brasileira. Neste artigo, procuro, em diálogo com a produção de Ayres sobre Projetos de Felicidade e saúde, refletir sobre a produção de cuidado em saúde no contexto brasileiro, considerando o racismo estrutural e o vigente mito da democracia racial na centralidade desta produção de cuidado. Enquanto instituição saúde e objetivando garantir saúde como direito à cidadania, deveríamos nos comprometer com projetos de felicidade ou viabilizar e apoiar projetos de emancipação e liberdade?
What if Dona Violeta was a black woman? Considerations on “O cuidado, os modos de ser (do) humano e as práticas de saúde”
Authors: Borret Rita Helena do Espírito Santo
Published: September 2022

Abstract Can we discuss humanization in health without bringing the expressions of racism in the health-ilness process to the centrality of the debate? Would it be possible to think of humanized care practices without considering structural and institutional racism in health? An affirmative answer to one of these questions reinforces the current myth of Brazilian racial democracy, which prevents us from recognizing or validating how much racism is alive in our society and produces unequal experiences of living, sickening, and dying for the black population, which accounts for more than 56% of the Brazilian population. In this article, in dialogue with Ayres’ production on Happiness Projects and healthcare, I seek to reflect on the production of health care in the Brazilian context, considering structural racism and the prevailing myth of racial democracy in the centrality of this care production. As a health institution aiming to ensure health as a right to citizenship, should we commit to projects of happiness or enable and support emancipation and freedom projects?
Agendas de saúde voltadas para gays e lésbicas
Authors: Gomes Romeu
Published: September 2022

Resumo O estudo objetivou validar agendas reivindicadas por representantes de grupos homossexuais voltadas para a atenção integral à saúde de gays e lésbicas. Para isso, foi elaborada uma matriz de agendas de saúde baseada na consulta a acervo de outro estudo, composto por 25 narrativas de representantes de 16 grupos de dez capitais brasileiras. As agendas foram consideradas validadas a partir da média de pontuações igual ou superior a sete e desvio padrão igual ou inferior a dois. As agendas validadas se relacionaram às seguintes temáticas: violência física ou psicológica; atenção às lésbicas relacionada aos cânceres de útero e mama; saúde mental; capacitação de profissionais de saúde; prevenção e atenção voltadas para a Aids; reprodução assistida para lésbicas; atenção a gays relacionada ao atendimento urológico e proctológico; desenvolvimento de materiais informativos sobre a saúde em geral; e informação e tratamento das infecções sexualmente transmissíveis. Conclui-se que os movimentos de gays e lésbicas podem ser atores importantes no âmbito da saúde coletiva, não só indicando pautas a serem consideradas nas políticas e nos planejamentos voltados para a saúde de seus integrantes, podem também ser mediadores entre os profissionais de saúde e os homossexuais que buscam os cuidados desses profissionais.
AN ANISOTROPIC EXTENSION FOR A THERMOVISCOPLASTIC GTN DUCTILE DAMAGE MODEL
Authors: Pascon João Paulo , Waisman Haim
Published: September 2022

In this work, a thermoviscoplastic GTN ductile damage model is extended to account for anisotropic plastic behavior. The novel feature of the proposed model is the enrichment of a GTN model, with the Hill's yield criterion accounting for hardening, softening, strain-rate effect, plastic work heating, thermal diffusion, and void shearing mechanism. The anisotropy is introduced by changing the equivalent stress definition, which provides greater flexibility to the model. The resultant modifications in the yield criterion and in the damage evolution equations are described. Two numerical problems involving plates subjected to tension loading that leads to ductile damage and eventual fracture are presented and discussed in order to validate the present approach. A mixed finite element formulation is adopted together with the fully damaged zone technique to represent the ductile fracture. Results obtained through computational simulations highlight the effect of the anisotropic parameters on mechanical behavior in terms of the global stress-strain curve and the local evolution of plastic strains, porosity and temperature. We conclude that the proposed anisotropic model is simple to implement yet provides more flexibility in capturing complex ductile fracture processes.
Saúde mental de pessoas transgênero: revisão integrativa de literatura
Authors: Alvares Joana , Penna Marcela Nunes , Garcia Lana Dal Magro , Falcke Denise
Published: September 2022

O fenômeno da transgeneridade ocorre quando a pessoa não se identifica com o seu gênero atribuído ao nascimento, o que geralmente é marcado por conflitos e lutas internas. O presente estudo objetivou mapear os estudos nacionais e internacionais sobre a saúde mental de pessoas transgênero nos últimos cinco anos. Foi desenvolvida uma revisão integrativa da literatura, seguindo o protocolo PRISMA (Preferred Reporting Items for Systematic Reviews and Meta Analyses), através de quatro bases de dados, utilizando os descritores “transexual OR transgender” AND “mental health. Os resultados foram analisados a partir de 16 artigos localizados e divididos em três categorias: agravos à saúde mental, fatores de risco e fatores de proteção. Evidenciou-se alta prevalência de agravos à saúde mental de pessoas transgênero, como sintomatologia deprimida e ansiosa, uso de substâncias psicoativas e álcool, tentativa e ideação suicida, comportamento auto lesivo e diminuição de autoestima. Os principais fatores de risco foram estigma social e preconceito, além de falta de apoio social. Por outro lado, os fatores de proteção à saúde mental foram suporte social, relacionamento conjugal funcional e possibilidade de processos de afirmação de gênero. Conclui-se que é de suma relevância que o cenário científico brasileiro possa contribuir para o aprofundamento da compreensão de questões de saúde mental no contexto nacional e para que se planeje estratégias interventivas de inclusão social e combate ao preconceito à identidade de gênero.
“Estamos sendo submetidos a uma escravidão disfarçada”: análise de relatos de motoristas de aplicativo à luz da Psicodinâmica do Trabalho
Authors: João dos Santos Jefferson , Bacarol Kerber Gabriel , Rissi Vanessa
Published: September 2022

O estudo teve por objetivo investigar e compreender as vivências de prazer e sofrimento, e as estratégias de mediação notrabalho a partir de publicações feitas por motoristas de aplicativos em um grupo numa rede social entre dezembro de 2019 e fevereiro de 2020. Foram selecionadas 282 laudas que passaram por uma análise temática e foram definidas em três categorias sob a luz da abordagem da Psicodinâmica do Trabalho: 1) as características do trabalho de motoristas por aplicativos; 2) as vivências de prazer e sofrimento no trabalho; 3) estratégias de mediação elaboradas pelos motoristas por aplicativos. O extrato das publicações realizadas por motoristas permitiu evidenciar que as inserções nas plataformas digitais surgem como alternativa ao desemprego ou complemento de renda. Os trabalhadores indicaram o reconhecimento dos passageiros e a gratificação como suas vivências de prazer. As vivências de sofrimento apontaram para características de servidão do trabalho e descontentamento, por razão da submissão por critérios de avaliação de desempenho, controle e vigilância pelos algoritmos digitais, e a imposição dos trabalhadores à uma intensa produtividade, longas jornadas de trabalho, baixa remuneração e falta de segurança. Foi possível notar estratégias de enfrentamento como a criação de clientelas particulares para aumentar seus rendimentos, a adoção de recursos tecnológicos para cuidados entre si, cooperação e compartilhamento de informações no ambiente virtual.
A late Pleistocene fossiliferous paleokarst site in the Western Mecsek Mts (Bükkösd, SW Hungary)
Authors: Sebe Krisztina , Szentesi Zoltán , Pazonyi Piroska , Surányi Gergely , Csillag Gábor
Published: September 2022

In the framework of a project studying the karst region of the Western Mecsek Mts in 2018–19, a new paleokarst cavity containing abundant vertebrate remains was found near the village of Bükkösd, extending the sparse Quaternary vertebrate record of the region. Th e herpetofauna is represented by a salamandrid, a true frog, lacertid lizards and colubrid snakes, the latter dominating the vertebrate material. Th e poor mammal material shows that the area was inhabited by insectivores, bats, mice, hamsters and voles. Th e vertebrate remains show no signs of long transport. Th e composition of the total vertebrate fauna suggests a sunny, rocky hillside with scrub and trees in places in the immediate vicinity of the accumulation site. Th e age of the charcoal recovered from the cavity fi ll (41–42 ka) suggests that the fauna is late Pleistocene (MIS 3), this makes the assemblage the fi rst proven MIS 3 fauna in southern Hungary. Th e re-evaluation of the paleokarstrelated fossil material previously reported from the Mecsek revealed a further assemblage probably also of MIS 3 age, the Mélyvölgy Rock shelter. Th e palaeoclimate reconstructed from the palaeoecological analysis of the faunas is warmer than that from coeval sites in northern Hungary, with more closed (forested) vegetation than the northern mammoth steppes. Th is refers to the existence of a north-south thermal gradient in the Carpathian Basin at the time. Th e U-series dating of speleo thems showed that the karst cavity had existed for more than 0.5 Ma. During MIS 3, the cavity stopped to be part of an active karst conduit and it was fi lled up by loess-derived silt. Th e site was lying above the karst water table then, and it may have acted as a trap either for the live animals or for the bones deposited on the surface. With 25 figures and 3 tables.
Honderd jaar Afrikaanse Woordelys en Spelreëls - 'n Oorsig en waardering. Deel 1: Die woordelys
Authors: Bosman N , Taljard E , Prinsloo D
Published: September 2022

In 2017 sal die Afrikaanse Woordelys en Spelreëls (hierna afgekort as AWS) 'n volle eeu oud wees, en hierdie bydrae gedenk die mylpaal met 'n (her)waardering van veral die woordelysdeel van die AWS. Aanvanklik word ŉ historiese oorsig gegee oor die ontstaan en ontwikkeling van die woordelys met 'n fokus op sy funksie, aard en omvang. 'n Evaluasie van die spelreëls het buite die bestek van die artikel geval, maar daar word wel kortliks stilgestaan by die grondbeginsels van die Afrikaanse spelling. Aspekte wat ondersoek is, was lemmakeuse, wat op sy beurt weer beïnvloed is deur beginsels van die Afrikaanse spelreëls soos 'n algemeen gebruiklike uitspraak, die bepaling van wat as "Standaardafrikaans" beskou kan of moet word en ander kwessies. Die doel en aard van die woordelys - kan dit byvoorbeeld as 'n spesiale soort woordeboek beskou word? - lemmaseleksie en mikrostrukturele bewerking, wisselvorme en die hantering van vreemde woorde, die normerende rol van die AWS en die omvang en volledigheid van die woordelys, kry aandag in hierdie eerste van twee artikels. Die gevolgtrekking waartoe gekom word, is dat die woordelys baie waardevol is as naslaanbron, maar wel tot 'n mate as belangrike gebruikersbron gekortwiek word deur sy aard: staties, onvolledig en voorskriftelik. Met die gebruiker in gedagte val die klem in Deel 2 dan op die nuwe moontlikhede wat 'n elektroniese woordelys sou kon bied.
Morbidade hospitalar das internações por urgências clínicas
Authors: Oliveira Tâmara Ingrid de , Moura Edilson Leite de , Moura Douglas Leite Leal , Santos Ana Caroline Melo dos , Farias Karol Fireman de
Published: September 2022

OBJETIVO: analisar o perfil epidemiológico das internações hospitalares por urgências clínicas em adultos. MÉTODO: Estudo descritivo, retrospectivo, com abordagem quantitativa. Os dados foram obtidos a partir do Departamento de Informática do SUS (DATASUS) oriundos do grupo Morbidade Hospitalar do SUS (SIH/SUS), entre janeiro de 2014 a dezembro de 2018. Para análise dos dados utilizou-se a estatística descritiva RESULTADOS: Esse estudo revelou que os homens são internados, principalmente, por doenças do aparelho digestivo e algumas doenças infecciosas e parasitárias (56,83%), enquanto que a internação das mulheres foi ocasionada, a priori, por doenças do aparelho geniturinário (84,4%), seguido de neoplasias (76,9%). Quanto aos grupos etários, identificou-se que indivíduos com idades de 50 a 59 anos tiveram o maior número de internações (27,1%). Ademais, durante o período analisado, observou-se um maior número de internações na primavera em se tratando de todos os grupos de doenças estudados. CONCLUSÕES: As doenças do aparelho digestivo e algumas doenças infecciosas e parasitárias foram as principais causas de hospitalização em homens, enquanto que doenças do aparelho geniturinário e neoplasias acometeram mais as mulheres.
EVALUATION OF ROCKWORK ELEMENTS USED IN THE GARDENS OF YILDIZ PALACE
Authors: UĞURYOL Drahşan
Published: September 2022

Rocks have been used in landscape architecture for both ornamental and plant growing purposes. In the historical process, developments in materials and design have turned rockworks into garden elements with high expressive power and artistic features in different cultures. Rocks were also included in the Ottoman gardens during the Westernization Period. Aim: The gardens of Yıldız Palace are important examples having elements made using artificial rock. Examining the designs, material properties and construction techniques of such garden items are important in terms of their conservation. In this context, Hasbahçe, garden of Şale Pavilion and Yıldız Park were chosen as the study area. Method: The rockwork arrangement in the gardens, the photographs in Yıldız Albums were examined, the relevant archival documents and literature were reviewed. Findings and Conclusion: It has been observed that these decorations built in the form of "rockwork" such as rocks, cliffs, grottos, and cascades are used on the edge of a promenade or stairs, or used on the shore of an artificial pond whether in the form of individual or groups of rocks, or used as part of a water element. Large-scale rockwork is not preferred in these gardens as in the other gardens of Yıldız Palace. It has been concluded that these elements are as qualified as those produced in Europe with their layout, design, other garden elements with which they are associated. However, it has been observed that some of the rockworks could not be preserved due to neglect, material deterioration and new garden arrangements, and a part of the survivors have conservation problems.
Morphological reconstruction of the bladder in the process of age-related involution
Authors: Kulikov Sergey V. , Shormanov Igor S. , Solovyev Andrey S.
Published: September 2022

BACKGROUND: Population aging has caused a steady increase in morbidity associated with gerontological pathology with lesions of various organs and systems, including those associated with structural changes in the bladder.
AIM: To study morphological rearrangements of the bladder and its vascular system in elderly and senile people.
MATERIAL AND METHODS: Autopsy material of the bladder wall from 25 men aged 6080 years was studied using histological, morphometric, and statistical techniques. As a control, we used material from 10 persons aged 2030 years who died from injuries.
RESULTS: Our results show that, in men in the process of aging, atherosclerotic changes occur in the extra-organic arteries,, leading to a narrowing of the lumen. In the intra-organ arteries, thickening of the media, hyperelastosis, and hyalinosis are observed, leading to a reduction in blood flow and are markers of arterial hypertension. The formation of the so-called closing arteries with a powerful intimate layer indicates adaptation to hemodynamic disorders. Over time, sclerosis grows in the media of arteries and in the intima of the closing vessels. The veins of the bladder lose a powerful smooth muscle layer in the wall and undergo sclerosis, making blood outflow difficult, and aggravating chronic hypoxia. Remodeling of the vascular bed of the bladder leads to detrusor atrophy and degenerative-dysregenerative changes in the urothelium.
CONCLUSIONS: In the vascular bed of the urinary bladder in elderly and senile men, atherosclerotic and angiotonic changes characteristic of arterial hypertension progress occur, followed by the development of detrusor atrophy and impaired urothelium regeneration.
Comparative characteristics of human stem cells
Authors: Pototska Olha Yu. , Shevchenko Ekaterina N.
Published: September 2022

Stem cell (SC) therapy is one of the most promising methods of clinical medicine. Although most stem cell-containing products are still being investigated in clinical trials, some of them are already approved for treatment in many countries. Therefore, modern medicine providing basic understanding of SC subtypes, their properties and potential risks should be incorporated in educational programs of medical universities.
The aim of this review is to compare SC types, methods of their procurement, and perspectives of their use.
Stem cells can be grouped according to the age of the donor organism. Embryonic SCs are those isolated from blastocysts, obtained from extracorporeal fertilization, cloning, semi-cloning or parthenogenesis (androgenetic and gynogenetic SCs). Fetal SCs are those isolated from embryonic and fetal tissues before birth or from miscarriage and abortion material (including ectopic pregnancies). Fetal SCs include a special group of perinatal extraembryonic SCs, which are obtained from extraembryonic organs (umbilical cord, amnion, placenta) after birth; among them hematopoietic, mesenchymal, epithelial and decidual cells are distinguished. Adult SCs (somatic or tissue specific) are isolated from different tissues and organs of adult organisms throughout their life. Their properties depend on their location and age of the donor. Additionally, induced pluripotent SCs are created artificially from mature cells by modification of gene expression. Every group of SCs is heterogenous and has its advantages and drawbacks analyzed in this review. Also considered in this review is the application of exosomes produced by stem cells as an alternative to cellular therapy.
Salt stress and ambience in the culture of yellow passion-fruit
Authors: Da Conceição Mendes Semedo Tamires , Gomes de Sousa Geocleber , Castelo Sousa Henderson , Baldé Bubacar , Nojosa Lessa Carla Ingryd , Machado de Sousa José Thomas
Published: September 2022

Salt stress negatively affects the emergence and initial growth of crops. However, the use of protected environments emerges as an alternative to enhance these parameters. In this sense, the objective was to evaluate the effect of different environments and the salinity of the irrigation water on the emergence and development of yellow passion-fruit seedlings. The experiment was conducted at the University for International Integration of the Afro-Brazilian Lusophony, in the city of Redenção, Ceará. The experimental design was entirely randomized in a subdivided plot scheme, with four cultivation environments under different shading screens (black screen; white screen; red screen; all with 50% shading; and full sun), and two electrical conductivities of irrigation water: 0.3 dS m-1 and 3.0 dS m-1, with five repetitions of 25 seeds. The protected environment with 50% black roofing stood out from the others providing a better percentage of emergence, seedling height, stem diameter, number of leaves and radicle length in yellow passion-fruit. The deleterious effects of salts on the rate of emergence and shoot dry matter were reduced when the 50% black shade cloth was used. Irrigation with water of higher conductivity caused reductions and retardation in the emergence of passion-fruit. Besides negatively affecting seedling height, stem diameter and shoot dry matter.
Bazı Bitki Ekstraktlarının Tribolium confusum’un Jacquelin Du Val (Coleoptera: Tenebrionidae) Larva ve Ergin Dönemleri Üzerine Etkileri
Authors: KÜÇÜKTOPCU Yeter , CAN Beyza , SARUHAN İslam
Published: September 2022

Bu çalışmada; sıcak ve soğuk su yöntemi ile Nigella sativa ve Lavandula angustifolia bitkilerinden elde edilen ekstraktların üçer farklı (10, 15 ve 20 w/w) konsantrasyonlarına ait süspansiyonları, önemli bir depo zararlısı olan Kırma un biti (Tribolium confusum Jacquelin du Val. (Coleoptera: Tenebrionidae))’nin ergin ve larva dönemlerine karşı fumigant etkileri üzerine değerlendirilmiştir. Çalışmada ayrıca ekstraktların T. confusum erginlerinin bir sonraki nesilleri üzerine olan etkisi de incelenmiştir. Tüm denemeler 4 tekerrürlü ve her tekerrürde 10 adet larva ve 10 adet ergin olacak şekilde yürütülmüştür. Çalışma, 27±2 °C ve %65±5 bağıl nem koşullarındaki tamamen karanlık inkübatörde yürütülmüştür. Çalışma ikişer gün arayla 13 gün boyunca takip edilerek ölü bireyler not edilmiş ve yüzde ölüm oranları belirlenmiştir. Uygulamanın 13. gününde L. angustifolia ekstraktlarının zararlının erginleri üzerindeki ölüm oranları, %5.71-62.86 arasında değişim gösterirken; zararlının larvaları üzerindeki ölüm oranları ise %75.68-91.43 arasında değişim göstermiştir. N. sativa ekstraktlarının zararlının erginleri üzerindeki ölüm oranları, %30.93-89.69 arasında değişim gösterirken; zararlının larvaları üzerindeki ölüm oranları ise %26.47-89.47 arasında değişim göstermiştir. Denemelerde kullanılan tüm bitki ekstraktları ise istatistiksel olarak kontrolden farklı grupta yer almışlardır (P=0.000). Yapılan çalışmaya genel olarak bakıldığında, bitki ekstraktlarının zararlının larvaları üzerindeki fumigant etkisi zararlının erginleri üzerindeki fumigant etkisine göre daha yüksek olmuştur. Zararlının erginleri üzerinde yürütülen çalışma sonucundaki F1 dölü üzerine etkisine bakıldığında ise N. sativa ekstraktlarının L. angustifolia ekstraktlarına kıyasla F1 dölünü azaltmada daha başarılı olduğu belirlenmiştir. Yapılan çalışmada N. sativa sıcak ve soğuk su ekstraktının %20 konsantrasyonunda zararlının yeni nesil yavru çıkışında %100 oranında azalma tespit edilmiştir. Sonuç olarak N. sativa ekstratlarının T. confusum zararlısı ile mücadelede etkili bir şekilde kullanılabileceği belirlenmiştir.
Afiliación sindical y satisfacción laboral: análisis del caso colombiano
Authors: Morales Martínez José Daniel , Moreno Monastoque César Augusto
Published: September 2022

Understanding how the perception of worker satisfaction can be influenced by union coverage would offer important elements for the design and implementation of labor welfare policies. This paper analyzes how unionization decisions in Colombia may affect employee satisfaction on various dimensions of well-being. For this study of the Colombian case, microdata from the 2015 Gran Encuesta Integrada de Hogares were used. The results are based on Linear Probability Models for job satisfaction functions, using a methodology that simultaneously controls for sample selection bias and the endogeneity of the union membership variable, based on an instrumental variables approach and two-stage estimators. The results highlight the relevance of unions as institutions of the labor economy that favor the welfare and quality of working life of their members, despite the political and socioeconomic difficulties that have affected the development processes of trade unionism in Colombia.
La gobernanza de datos en la gestión organizacional de las instituciones de educación superior: un análisis bibliométrico
Authors: Jiménez-Ramos Luisa M , Villa-Garzón Fernán A , Branch-Bedoya John W
Published: September 2022

Organizations consider data as essential assets for their operation; data represents the people, processes and technology that make it up. In other words, data is a necessary input for the business, its organizational management and competitive advantage, which must be aligned with its governance. In this work, a bibliometric analysis is carried out on the relationship that Data Governance has in the Organizational Management of Colombian Higher Education Institutions, since it is essential that researchers interested in this topic have a global vision of the state of the studies carried out in the global context. For the analysis, the review of 407 documents from the Scopus database was taken into account with an observation window of the last 10 years, between 2012 and 2022, using the keywords such as organizational management, data, data governance and its variations.
Origen, evolución y tendencias de investigación en marketing: Una perspectiva analítica desde el mapeo científico enriquecido
Authors: Duque-Oliva Edison Jair
Published: September 2022

This article seeks to retrospectively identify the research developed in the last twenty years of marketing literature and how it is associated with the progress of schools of thought in marketing. For this purpose, a bibliometric review based on co-citation and scientific mapping tools enriched by network analysis is carried out in order to provide some research suggestions based on clusters that give an overview of the progress of research in the discipline. In terms of its design, methodology and approach, a bibliometric analysis enriched with networks is developed under the procedure of Donthu et al. (2021).
The results show seven retrospective trends in marketing research: 1. The marketing and consumer process in a social world (offline, online); 2. The performance and impact of business at local, regional and international levels; 3. The psychology of the consumer; 4. The performance of service and customer relations; 5. The characteristics and models of advertising in the social context and its effects on social networks; 6. These elements gather the research of the last twenty years in the marketing discipline and provide information on how the research has evolved and where it can go.
This article contributes to a theoretical and general understanding of the evolution of marketing research with an approach from data science and enriched bibliometric techniques, in a broad and introductory way, but not in a deep way. Due to the amount of data, the result is global, but there is a need for further development of this type of reviews with greater delimitation and depth in the study of specific research production and thus contribute to a greater understanding of marketing as an academic discipline and its areas of action.