bluuebunny/crossref_metadata_2025 huggingface dataset:
Software tools for analysis and synthesis of stochastic systems with high availability (XII)
Authors: Konashenkova T.D. , Sinitsyn I.N. , Sinitsyn V.I. , Korepanov E.R.
Published: November 2021

The article proceeds the thematic cycle dedicated to analysis and synthesis for mean square criteria software tools for vector nonstationary (e.g. shock disturbances) linear stochastic systems with high availability (StSHA). Methodological support is based on Haar wavelet expansions (WLE) and wavelet canonical expansions (WLCE). Sect.1 is dedicated to problems statements. General basic algorithm is given in Sect. 2. Algorithms for StSHA with linear parameters and additive noises based on WLE and WLCE are described in Sect.3. Software tools in MATLAB are considered in Sect. 4. For typical shock disturbances bank of algorithms is developed. Complex of examples is given in Sect.5. Some generalizations are presented.
The methodological approach to the evaluation of the stability of the digital data in the information systems
Authors: Solovyev A.V.
Published: November 2021

When developing information systems aimed at long-term storage of digital data, it is necessary to think over solutions that allow not only to ensure storage security, storage reliability, but also to ensure the safety of digital data in the event of a possible destabilizing effect, including a catastrophic one. That is, there is a need to ensure the stability of digital data under natural, man-made, anthropogenic or other stored influences. The first step towards digital data resilience is to assess data resilience. The aim of the work is to develop a methodological apparatus for assessing the stability of digital data in information systems operating in conditions of disasters and destabilizing factors. The article presents a methodological approach to assessing the stability of digital data, including long-term storage. The stability of digital data to destabilizing influences in the article is understood as the ability to recover in a minimum period of time both the data itself and the operability of applications responsible for the interpretation of this data, as well as the operability of other software and hardware, without which the use of digital data is not possible. The author of the article proposes a methodology for creating a mathematical model for assessing sustainability, presents a model for assessing the sustainability indicator in general. The main steps for the development of a mathematical model of stability are described. Areas of further research on the development of methodological and algorithmic apparatus for modeling the stability of digital data have been identified. The methodological approach proposed in the article can be used to solve the problems of stability of digital data of a fairly wide class of applied information systems operating in conditions of disasters and destabilizing factors. The proposed approach presupposes redundancy of software and hardware of information systems, additional time spent in the design for compiling models, additional costs for storing the "history" of the functioning of information systems, description of destabilizing factors, etc. However, according to the author of the article, this is necessary and justified to ensure the safety of valuable digital data with a long storage period.
Intracavity antenna for multichannel radiothermograph
Authors: Nazarov V.G. , Agasieva S.V. , Sedankin M.K. , Vesnin S.G. , Leushin V.Yu. , Dudkin D.I. , Myshletsov I.I.
Published: November 2021

The development of an intracavitary multichannel diagnostic radiothermograph based on monolithic integrated circuits will allow creating a medical device that allows diagnosing diseases of internal organs of the human body. Purpose: to consider the option of constructing a diagnostic intracavity antenna with several measurement channels for a multichannel radiothermograph built on the basis of monolithic integrated circuits. A variant of constructing a multichannel radiothermograph for intracavity thermometry, implemented in the form of an intracavity antenna with five channels, a microwave switch and a microwave single-channel radiometer, is proposed. The intracavity antenna allows you to measure the temperature at five points of the biological cavity. The antennas are switched using a multi-channel switch integrated with the microwave radiometer. The conducted theoretical studies confirm the possibility of using multichannel microwave radiometry in medicine for intracavitary thermometry The basis for creating a model of a multichannel microwave radiothermograph based on monolithic integrated circuits for intracavitary examination is laid.
Thematic Analysis on COVID-19 Photojournalism in Indonesia
Authors: Widiatmojo Radityo , Fuad Moch Nasvian
Published: November 2021

The spread of COVID-19 in Indonesia is massive in terms of sufferers. This article aims to seek how national photo news agency ANTARA visualized the pandemic as part of contribution to COVID-19 research in the communication field. By utilizing thematic analysis and qualitative approach, the researchers want to identify, analyze, organize, describe, and report particular themes within an extensive data set of 466 photojournalism. The photos collected from www.antarafoto.com, start from 1 May until 12 May 2020. The finding shows that ANTARA visualized the current Indonesian condition of facing COVID-19 in 8 main themes, determined the countless efforts of ANTARA photojournalists working with a new protocol, and simultaneously also face the new resistance from society. The most popular theme produced by ANTARA photojournalists is economics (183 photos), Social (164), and health (80). Discussion on the most popular is divided into specific topics, namely location, subject’s gender, photographic approach, image format, and news photo category. By utilizing visual ethics on the field, photojournalists communicate the symbols and reality of the real world into a frame to change people’s views about COVID-19 amid the increasingly uncontrolled infodemic flow.
A avaliação institucional e a gestão na/da educação infantil em meio à covid-19
Authors: Louzada Virgínia , Amancio Cristiane , Rossato Bruno
Published: November 2021

Este ensaio discute os processos de avaliação numa perspectiva da gestão democrática e participativa com o grupo de professoras de uma instituição pública de educação infantil do Rio de Janeiro, no cenário gerado pela pandemia da covid-19. Buscou-se compreender como as concepções presentes nos discursos e fazeres docentes traduzem-se em práticas pedagógicas que possibilitem experiências significativas às crianças menores de seis anos. Para tanto, utilizou-se a avaliação institucional como caminho formativo para que as docentes e os gestores pudessem refletir sobre suas ações naquele contexto, gerando a qualificação das práticas. Os resultados indicam que esse é um processo em desenvolvimento na instituição e evidenciam a potência da avaliação para a formação continuada de professores.
What drives DS30 Index amid bourse lockdown decision? An emerging economy perspective
Authors: Faruq Mohammad Omar
Published: November 2021

This study measures the impact of the COVID-19 pandemic outbreak on the stock market of Bangladesh amid bourse lockdowns. The top 30 blue-chip companies listed in the DS30 Index of the Dhaka Stock Exchange are used as the sample for this study. Panel data regression analysis has been used after performing several diagnostics tests to assess the impact for January to December during the year 2020. The regression model used in the study considers three key aspects, namely COVID-19, firm-specific factors, and macroeconomic variables amid the bourse lockdown. This study finds that daily trend in affected cases, death cases and investors' attention significantly affect the stock market but does not show any negative relation to conclude. The Government imposed lockdown shows a negative relation with the stock market significantly. Firm-specific variables like daily market capitalization and book to market ratio show a significant negative relationship with the stock market. On the other hand, macroeconomic factors have a significantly positive impact on the stock market amid bourse lockdowns. This study assesses the performance of the Bangladesh stock market by use of DS30 Index listed firms during the COVID-19 pandemic in response to the Government imposed bourse lockdown. This study provides unique insights into how the Bangladesh stock market reacted during the pandemic, along with a rare bourse lockdown decision.
Determinants of Sustainability of Rural Agricultural Projects in Rwanda: Case of Maize Projects in Budubi Irrigation Scheme in Nyanza District
Authors: Alice MUHONGERWA
Published: November 2021

This study aimed at assessing the influence of financial input on the sustainability of maize projects in Budubi Irrigation Scheme; to investigate influence of Irrigation Scheme management on the sustainability of maize projects in Budubi Irrigation Scheme; to examine influence of benefits from maize on the sustainability of maize projects in Budubi Irrigation Scheme and to assess influence of care for environment on the sustainability of maize projects in Budubi Irrigation Scheme. The study was guided by the sustainability theory and applied a descriptive cross-sectional design, and population of 392 persons out of which a sample of 198 was applied. Document review, questionnaire, interview, and observation methods were used to collect data, while descriptive statistics and content analysis was applied for data analysis.

Key words: Irrigation scheme, sustainability, agricultural projects, Maize projects.
Analysis of Bus Passenger Demand and Supply: Case Study on Western Province, Sri Lanka
Authors: Amalan Thivya
Published: November 2021

Buses carried about 47% of passengers crossing the Colombo Municipal Council (CMC) boundary in 2013. The Sri Lanka Transport Board (SLTB) and private bus companies operates roughly 680 intra-provincial bus routes and 400 inter-provincial bus routes in the Western Province according to the bus route information from the National Transport Commission (NTC, 2012) . The number of buses on the seven (7) major radial corridors carries more bus passengers than other roads in the Western Province. Kandy, Galle and Malabe Road corridors are the highest followed by High Level, Negombo, Horana and Low Level Road corridors. This research paper is an attempt to analyse the bus passenger demand and supply on seven major corridors connecting Western Province boundaries. The impact of the passenger demands and volumes from the seven major corridors and the traffic speed are the main outcome of this analysis. The present bus traffic information and the impact of the traffic congestion due to the high traffic flow on major corridors are discussed in the analysis. The research will also focus on alternative solutions and the importance of integrating other public transport modes to cater the demand from the major seven corridors for the better utilisation of public transport inside the Western Province boundaries.
Establishment of an Innovative Telehealth Speech and Language Therapy Placement as a Rapid Response to COVID-19: Sharing the Learning
Authors: Lyons Rena , Loftus Laura , Rodden Margaret , Ward Lynch Siobhan , Gaffney Sonya , McAndrew Brid
Published: November 2021

The aim of this evaluation was to explore practice educators’ and speech and language therapy (SLT) students’ experiences of a rapid response telehealth placement in response to the COVID-19 pandemic in order to inform quality improvement. In March 2020, public health restrictions were imposed across Ireland in efforts to ‘flatten the curve’ in response to the COVID-19 pandemic. All placements were cancelled. According to an Irish Association of Speech and Language Therapists survey in April 2020, 47% of SLTs were redeployed to swabbing and contact tracing roles, and many remain redeployed seven months later. This redeployment, along with strict public health measures in clinical sites, significantly reduced the availability of clinical placements. A rapid response was required to enable students to develop clinical competencies. Although telehealth has been used to deliver speech and language therapy in other countries, it had not been used routinely in service provision in Ireland. In this article, we outline how we built on existing partnerships with practice educators, both on- and off-site, to design a much-needed telehealth placement. We explored educators’ and students’ experiences using an online focus group and online survey respectively. The evaluations of practice educators were positive in that despite their initial apprehension, they reported that this placement provided valuable learning opportunities for students while also providing benefits for clients. They also reported some technological and sustainability challenges. The students also evaluated this placement positively with 83.3% of respondents rating the placement as ‘excellent ‘and 16.7% rating it as ‘good’. All stakeholders valued this learning experience.
Analyse transversale des activités et paradigme de la transformation
Authors: Marynowicz-Hetka Ewa
Published: November 2021

Le but de cet article, intentionnellement préparé pour le numéro thématique « Pensée transformation » est de montrer comment l’analyse transversale des activités et le paradigme de la transformation, présents dans l’œuvre de Jean-Marie Barbier (2016, 2017), traversent également la perspective socio-pédagogique. Dans le texte, nous réfléchissons sur les cadres épistémologiques et les caractéristiques de l’approche transversale ainsi que sur ses relations avec le paradigme de la transformation. Le concept d’analyse transversale de l’activité et ses liens avec le paradigme transversal de la transformation en pédagogie sociale sont également introduits.
Transformer les perceptions avant d’engager l’action
Authors: Hyppolite Marie Jasmine
Published: November 2021

Les transformations perceptives sont à la fois des produits de l’interaction et des outils pour l’interaction. Les changements de perceptions et des cadres perceptifs contribuent à la construction de nouveaux possibles d’activités. Les acteurs disposent de nouveaux canevas prêts à agir dans leur environnement « ici et maintenant » mais également pour « demain et ailleurs » Engagés dans des situations de crise, d’incertitude, les transformations perceptives se mobilisent. Notre étude « se préparer à une action de négociation collective » éclaire la façon dont les acteurs se construisent afin d’anticiper la pression inhérente à la singularité de cette situation. Une approche anthropologique des activités permet l’analyse de l’interaction des acteurs présents. Emergent des « mouvements conversationnels » mettant en lumière le processus de transformations des activités et de transformations des acteurs en activité. Les ruptures, les articulations et les continuums sont repérés. Les résultats manifestent une catégorisation des activités de transformation.
Transformacje życia profesjonalnego asystentów rodziny: komunikowanie doświadczeń
Authors: Kamińska-Jatczak Izabela
Published: November 2021

Przedmiotem przeprowadzonych badań były doświadczane transformacje życia profesjonalnego ujawnione w komunikacji asystentów rodziny. Efektem tej komunikacji są zapisy wypowiedzi, które poddano konceptualizacji w oparciu o podejście transwersalnej analizy aktywności − holistyczne ujmowanie aktywności profesjonalnych i spoglądanie na nie przez pryzmat procesów transformacji, jakie nieustannie się w nich dokonują. Wypowiedzi asystentów skonceptualizowano pod kątem zidentyfikowania modyfikacji procesów transformacji życia profesjonalnego, na które one wskazywały. W rezultacie interpretacji wyłoniono styl komunikowania doświadczenia profesjonalnego. Tekst sugeruje możliwość wykorzystania potencjału interpretacji, jaki można wydobyć z komunikacji o zmianach zachodzących w życiu profesjonalnym, w procesie stymulowania refleksji podmiotu działającego.
Forming cognitive activity in primary school students with samples of folk oral literature
Authors: Elmira Uaidullakyzy , Omarov Nurlybek , Konyrbayeva Sarash , Jazdykbayeva Mariya , Orazbayeva Elmira , Tautaeva Guldariga , Eskaraeva Aigul
Published: November 2021

The goal of every nation is to raise a healthy and conscious generation that will continue their life and experience. Therefore, in this article, the aim was to comment on the concepts of samples of folk oral literature and analyze the problem of forming the cognitive activity of Primary School students. In this regard, the research work was carried out in primary classes of multidisciplinary Secondary School No. 156 in Almaty (Kazakhstan). The participants were primary school teachers and primary school students who participated in a pedagogical experiment. The results were analyzed using percentages.  As a result, it was concluded that tasks prepared using samples of oral folk art and effective and modern methods of its use in the classroom allow us to form the cognitive activity of Primary School students. This, in turn, contributes to the comprehensive development of students as a person.

Key words: samples of oral folk art, cognition, cognitive activity, Primary School students.
Repercussions of Covid-19 crisis on students’ remote learning in Saudi universities
Authors: Al-Qahtania Norah , Al-Salem Wafa Abdullah
Published: November 2021

This study aims to identify the positive and negative repercussions of the novel Coronavirus crisis on students’ remote learning in Saudi universities. A descriptive survey method is carried out using a questionnaire and distributed to a cluster sample of 651 undergraduate students. Results reveal the most prominent positive repercussions, which are that the university cares about the learners' safety and health health and places them at the highest priority, review of recorded lectures and investing time. Results also reveal the most prominent negative repercussions, which are students’ concern about their academic conditions, reduced access to teaching and research facilities and laboratories, and large assignments. Statistically significant differences are also found in favour of males, health disciplines, and King Faisal University and University of Hail.
 
Keywords: Repercussions,covid-19, student,remote learning,Saudi universities
Do direito à tortura
Authors: Dos Santos Fernandes Ionara
Published: November 2021

A tortura é uma prática milenar que atravessa continentes. No Brasil, ainda que proibida e criminalizada, segue sendo exercida. Atualmente apresenta uma série de variações que estão em disputa no âmbito conceitual, político e jurídico no país e no mundo. Neste trabalho, a partir de um estudo de caso, faço uma análise das variações da tortura, identificadas a partir de um incêndio ocorrido em uma unidade socioeducativa do Rio de Janeiro, registrado por um órgão de fiscalização dos espaços de privação de liberdade, o Mecanismo Estadual de Prevenção e Combate à Tortura do Rio de Janeiro.  Observou-se que a arquitetura precária e antiga da unidade, a superlotação e o acesso limitado e inadequado aos serviços de saúde se configuram em práticas de tortura no corpo populacional, e ainda se articulam com práticas de violência individualizada. Tais ações são articuladas e implementadas por diversas instituições, evidenciando que as práticas de tortura são conformadas a partir das relações de poder, fundamentadas nas desigualdades.
Technical and economic comparison of power supply systems providing various degrees of reliability
Authors:   Ural state university of railway transport (USURT), Pyshkin Anatolij A. , Lesnikov Dmitrij V. ,   Ural state university of railway transport (USURT)
Published: November 2021

The article presents a method of technical and economic comparison of power supply systems with different degrees of reliability, taking into account the potential economic damage from power supply interruptions. At the same time, the economic damage is determined based on the probability of emergency operating conditions and planned repair of a power supply system. In the vast majority of cases, it is inappropriate to achieve an excessive increase in the reliability of a power supply system, as this may lead to an economically unprofitable solution.
Anti-bacterial activity of Rosela Flower Extract (Hibiscus sabdariffa L.) against Extended-Spectrum Beta-Lactamase (ESBL) Eschericia coli
Authors: Fathoni Muhammad Mu’amar , Isnaeni Isnaeni , Darmawati Asri
Published: November 2021

Roselle (Hibiscus sabdariffa L.) contains cyanidin-3-rutinoside, delphinidin, delphinidin-3-monoglucoside, cyanidin-3-monoglucoside, cyanidin-3-sambubioside, cyanidin-3,5-diglucoside may inhibit the growth of Extended-Spectrum-Beta-Lactamase (ESBL) Escherichia coli, but there is no research reported the determination of MIC of Roselle (Hibiscus sabdariffa L.) extract powder against ESBL E.coli ATCC 6110 and ATCC 5949 and their potency ratio compared to meropenem. This study aimed to determine the MIC of Roselle flower extract powder on the growth of ESBL E. coli ATCC 6110 and ATCC 5949 and determine the potency ratio compared to meropenem. This study used two methods in determining MIC, namely the agar diffusion method and the dilution method with Nutrient Agar media which was incubated at 37 ±1°C for 24 hours, while the determination of the potency ratio was carried out by diffusion method with the same media which was incubated at 37 ±1°C for 24 hours. The results obtained were diameter of inhibition zone (mm) which were then observed and analyzed to calculate the potency ratio. The results showed that the MIC of Roselle flower extract powder was obtained at a concentration of 12,500 ppm by diffusion method and at a concentration of 3,125 ppm by dilution method with 24 hours incubation at 37 ± 1o C and the potency ratio of Roselle flower extract powder compared to meropenem was 89.7% and 97.97% against ESBL E.coli ATCC 6110 and ESBL E.coli ATCC 5949 respectively.
Carcinoid of the Operated Stomach: Difficulties in Diagnosis
Authors: Nudnov N. V. , Kolesnikov R. V. , Bolotina N. A. , Vorob’eva V. O.
Published: November 2021

Gastric neuroendocrine tumors commonly called carcinoids arise from enterochromaffin cells of the stomach and are rare. Recently, their incidence has increased, which may be due to the improvement of diagnostic and therapeutic capabilities. The article describes a rare clinical case of gastric carcinoid 23 years after surgical removal of gastric cardia cancer.
Améliorer l'efficacité des systèmes laitiers herbagers en milieux tempérés
Authors: DELABY Luc , HORAN Brendan
Published: November 2021

Au cours des prochaines décennies, la croissance démographique, l'urbanisation et l'augmentation des revenus, en particulier dans les pays en développement, laissent présager une hausse significative de la demande alimentaire mondiale. L'augmentation de la production agricole devra cependant être obtenue avec une efficacité accrue et dans le respect de l'environnement. Les prairies, qui couvrent une grande partie de la planète, constituent une ressource indirecte importante dans l'approvisionnement alimentaire mondial, grâce notamment aux ruminants qui les valorisent. Dans ce contexte, les productions animales issues de systèmes basés sur les prairies et le pâturage s’avèrent bien placées pour fournir des aliments de qualité destinés à la consommation humaine tout en assurant une grande variété de services écosystémiques. Des progrès notables ont été réalisés dans la gestion des prairies afin d’assurer à la fois une productivité élevée et une production alimentaire de qualité. Le rôle des quantités d’herbe offerte et de la hauteur d’herbe résiduelle a été mieux quantifié et les règles de gestion à l’échelle de la parcelle ont ainsi pu être élaborées afin d’optimiser le compromis entre l’herbe valorisée par vache et par hectare. À l’échelle de la saison de pâturage, les conditions de réussite reposent à la fois sur une gestion rigoureuse, et sur des vaches dont les caractéristiques génétiques spécifiques, notamment l’aptitude à se reproduire, sont mieux connues. Le défi pour les éleveurs est d’aboutir à une valorisation plus efficace des pâturages grâce à gestion mieux anticipée et adaptée aux conditions spécifiques de l’année, de leur parcellaire et de leur situation d’élevage. Ainsi, le développement et la diffusion d'outils d'aide à la gestion du pâturage pour conforter la prise de décision reste un objectif important pour les organismes de recherche et de développement dans le monde entier.
INVENTARISASI, KARAKTERISASIMORFOLOGI, DAN UJI VIABILITAS BENIHPACAR TERE (Impatiens platypetala Lindl.)HASIL EKSPLORASI DI KAWASAN TAMAN NASIONAL BROMO TENGGER SEMERU
Authors:   Pusat Penelitian Konservasi Tumbuhan dan Kebun Raya LIPI, Renjana Elga , Rahadiantoro Apriyono , Wige Ningrum Linda , Ayu Lestari Dewi , Rifqi Firdiana Elok , Trimanto Trimanto , Mas'udah Shofiyatul , Hapsari Lia
Published: November 2021

BromoTenggerSemeruNationalPark(BTSNP)isoneofnaturalconservationareasinEastJavawitharound1,025plantspecies.Impatiensplatypetala,locallyknownaspacartere,isaplantspeciesmostlybefoundinmountainousareasofJavaandwithhighpotentialasmedicinalandornamentalplant.However,researchonthisspeciesisstilllimited.Thisstudywasconductedtoinventory,describethemorphologicalcharacteristicsandtesttheseedviabilityofpacartereinfourresortsofBTSNP,namelyRPTNGunungPenanjakan,CobanTrisula,Senduro,andRanuDarungan.Surveymethodwasusedtoinventorytheplantpopulations.Directfieldobservationwasusedtocharacterizetheplantmorphology.Seedsviabilitytestwasconductedthroughgerminationonstrawpapermedia.TheresultsshowedthatpacarterepopulationswerefoundinthosefourBTSNPresorts,onshadeandhumidhabitats,alsoinopenareaswithwetsoilconditions.Theplantischaracterizedasanerectparennialherb,spursedpinkflower,capsulafruitwhichdehiscentwhenripe,withflattenedcone-shapedandsmoothhairyseeds.Seedgerminationtestshowedthattheseedsbegantogerminateonday5aftersowing(around20sprouts/day),epigealtype,withpercentageofgerminationandviabilitywas56%and90%respectively.ResultsofthisstudyareexpectedtoprovidebasicinformationtosupporttheconservationeffortsofI.platypetalabothin-situandex-situ(seedandlivingplant),alsoitspropagationeffortsforfurtherbioprospectingresearches
Classification of energy impacts by their effect on the structure and properties of reinforced reactoplasts
Authors: Cheremukhina I. V.
Published: November 2021

The use of various physical influences is an economical and highly effective direction for regulating and improving the characteristics of the modified reinforced polymer composite materials developed in this work. The methods of energy effects studied in this work were used at the stage of impregnation of technical threads of various chemical nature with an oligomeric binder and a hardener (when preparing prepregs by the traditional method) or with a binder solution and a curing system (when preparing prepregs by the method of layered application of components) Based on the conducted research, a classification of the applied methods of physical modification according to the principle of the influence of energy fields is proposed. The studied methods of energy effects are divided into orienting and energetically energizing effects. The first group includes treatments with constant magnetic (PMP) or electric fields (PEP), and constant mechanical loads. The second group includes energy effects that have a wave nature (energetically energizing), and vibration, ultrasonic effects, and ultraviolet radiation are attributed to them. Modification methods of the first group contribute to a decrease in the mobility of binder molecules during curing, while the formation of branches of polymer chains occurs during the curing process, which leads to a predominant increase in the destructive stress during static bending. Energetically energizing effects contribute to the relative acceleration of the process of linear growth of polymer chains during curing, which is accompanied by the formation of a more sparsely cross-linked mesh structure, which leads to a predominant increase in impact strength. Of the two competing processes in the curing of epoxy oligomers, this one requires a higher activation energy, which is confirmed by the results of studies. Analyzing the results obtained, it can be concluded that the modification methods used in the work allow not only to obtain polymer composite materials with high strength characteristics, but also to directly adjust the properties of composites depending on the requirements for the products. Orienting modification methods lead to hardening of the resulting polymer composite material with a predominant increase in the destructive stress during static bending from 20 to 47%. When using energetically energizing influences in the technology of producing reinforced reactoplasts, the impact strength increases mainly from 19 to 40%.
Application of the method of differential scanning calorimetry in the study of the properties of oilseeds
Authors: Saranov I. A. , Rudakov O. B. , Polansky K. K. , Ramazanov A. S. , Balaeva S. A. , Kiselev D. S.
Published: November 2021

The method of differential scanning calorimetry (DSC) is used to characterize the thermophysical properties during melting of samples of milk thistle oil of various geographic origins, seeds and meal. The world experience in applying the DSC method on the study of milk thistle oils is generalized. The temperature measurement program is described. It is shown that, despite the general similarity of the curve profiles of the melting DSC, there are differences in the profiles due to genotypic and phenotypic factors - variety and growing location. The DSC curves of freshly squeezed oil distinguish from the DSC curves after 6 months storage of the oil due to oxidative deterioration and the formation of more refractory partially oxidized triacylglycerols. This fact is relevant to determining the capabilities of the DSC method in controlling the freshness of vegetable oils. The peaks amplitudes in the DSC curves of fresh oil are higher than those of oils that has been stored at room temperature for six months. Double differentiation of the melting curves makes it possible to reveal the temperatures of phase transitions in the case of overlapping endothermic peaks, the establishment of which is difficult without double differentiation. Using the «Netzsch Peak Separation» software to divide the peaks in the melting curves allows at once to estimate the areas of overlapping peaks and increase the informativeness of the DSC data. Thermal analysis of milk thistle seeds and meal reveals that the meal contains a residual amount of oil, in which the proportion of triunsaturated fats is overestimated in comparison to seeds, indicating that triunsaturated fats are more difficult to extract from oil by cold pressing.
Mathematical Incorrectnes of So Called Higuchi‘S Fractal Dimension
Authors: Martišek Dalibor
Published: November 2021

So called Higuchi’s method of fractal dimension estimation is widely used and the term Higuchi’s fractal dimension even occurs in many publications. This paper deals with this method from mathematical point of view. Terms distance and dimension and its basic properties are explained and Higuchi’s dimension according the original source is defined. Definition of Higuchi’s dimension was comparated with mathematical definition of the distance and dimension. It is showed, that the definition of the Higuchi’s dimension does not satisfy axioms of distance and dimension. So called Higuchi’s method and Higuchi’s dimension are mathematically incorrect. Therefore, all results achieved by this method are scientifically unreliable.
Locally Advanced Rectal Cancer Patients Got PCR After Chemoradiotherapy May Have Better Survival Outcomes: A Retrospective Analysis of 246 Patients.
Authors: Wang Yong , Liu Dongyan , Peng Lisha , Wang Feng , Li Rongqing
Published: November 2021

Objective: To investigate whether the locally advanced rectal cancer patients who got a pathological complete response after neo-adjuvant chemoradiotherapy have a better survival. Methods: From January 1 2014 to January 1 2018, the clinical information of locally advanced rectal cancer patients who underwent neo-adjuvant chemoradiotherapy were collected for a retrospective analysis. Then a telephone follow-up visit was done to get the patients’ survival information of progression-free survival and overall survival. At last the information was analyzed by Kaplan-Meier analysis, log-rank test and cox-regression analysis. Results: The clinical information of 246 locally advanced rectal cancer patients were collected and analyzed, which shows that the PCR rate after chemoradiotherapy was 20.3% in these patients. There were correlations between pathological grade(grade III-IV Vs. I-II, P=0.001), CRM invasion(positive Vs. negative, P=0.001), clinical T stage(T4 Vs. T1-3, P=0.000), PCR status(PCR Vs. Non-PCR, P=0.027), downstage after preoperative therapy(yes Vs. not, P=0.009) and PFS. Similarly, age(≤60 Vs. >60, P=0.000), pathological grade(grade III-IV Vs. I-II, P=0.016), EMVI status(positive Vs. negative, P=0.005), CRM invasion(positive Vs. negative, P=0.000), clinical T stage(T4 Vs. T1-3, P=0.000), clinical N stage(N0-1 Vs. N2, P=0.013), PCR status(PCR Vs. Non-PCR, P=0.010), downstage after preoperative therapy(yes Vs. not, P=0.002) were associated with the OS. After the Cox-regression analyses, the responses after preoperative therapy or T4 tumors were identified as the prognostic factors that affected PFS and OS. Conclusions: The PCR rate after chemoradiotherapy was 20.3% in locally advanced rectal patients. Stage T1-3, better response after chemoradiotherapy tumors (PCR or downstage) might have a better survival outcome.
Contextualising English generalist day centres for older people: operational characteristics and typical days. Findings from case study research
Authors: Orellana Katharine , Manthorpe Jill , Tinker Anthea
Published: November 2021

Reports of Covid-19 pandemic related day centre closures impacting negatively on their attenders and family carers have fuelled a resurgence of interest in these services. The absence of detailed descriptions of this common, but often ‘invisible’, preventive service from the literature limits the evidence base since outcomes data without context are less meaningful. This descriptive article aims to demystify these diverse and multi-faceted settings by painting a rich, contemporary, pre-Covid pandemic picture of four purposively selected English day centres for older people using data from diary notes made during 56 full-day visits, documentation provided by centre managers, and interviews with 23 centre managers, staff and volunteers. The article aims to further understanding of these settings for potential collaborators and social care and health professionals, particularly in the context of rising social prescribing initiatives in England with their focus on linking older people to asset-based community resources. We provide baseline data for conversations concerning optimisation of such services in the post-pandemic recovery period and beyond: how buildings may be regarded as valuable community assets with potential, and how other parts of the health and care system may better interact with day services to improve older people’s, carers’ and others’ health and wellbeing, and to benefit of staff working elsewhere in health and care.
“Such Conversations Are Not Done in the Families”: A Qualitative Study of the Determinants of Early Adolescents’ Access to Sexual and Reproductive Health and Rights Information in Rwanda.
Authors: Mbarushimana Valens , Conco Daphney Nozizwe , Goldstein Susan
Published: November 2021

Background

Acces to sexual and reproductive health and rights information during adolescence is a basic human right. This study investigated the key informants’ perspectives on the benefits, sources of information, and the determinants (enablers and hindrances) of sexual and reproductive health and rights information among early adolescents in Rwanda.
Methods

a qualitative study using semi-structured interviews with purposively selected public and private key informants in Rwanda was conducted. Interview transcripts were imported in Nvivo 11 for thematic analysis.
Results

In total, sixteen interviews involving an equal number of male and female participants were conducted. Despite it being perceived as a taboo topic, participants acknowledged sexuality education as beneficial for early adolescents and confirmed that there are various channels for accessing gender and sexuality information. The school comprehensive sexuality education was depicted as a common source of information, while parents were not. Participants highlighted disparities in information access between rural and urban settings. Faith-based organizations and public institutions did not share the same perspective on the topics that should be covered in gender and sexuality education. Faith-Based Organizations focused on moral values of abstinence and virginity, while public institutions emphasized ways of having safe sex including the use of modern contraceptive methods. Participants noted the need to address the confusion about the concept of gender. Participants’ reflections on gender dynamics revealed that compared to girls, boys culturally override sexual health. Participants thought that access to gender and sexuality information by early adolescents depended on multiple factors at the individual (curiosity, age, behaviours), relationships (discussions with parents, peer sexual norms), community (the content of the curriculum, culture, religious beliefs), and societal (economic challenges, policy, and laws) levels.
Conclusion

Participants from various backgrounds acknowledged the benefits of sexuality education, as well as the various channels available to younger adolescents for accessing SRHR information, even though their perspectives on the content differed. The study’s multi-layered analysis revealed potential areas for improving early adolescents’ access to gender and SRHR information.
Association Between the Dietary Literacy of Children's Daily Diet Providers and School-age Children's Nutritional Status and Eating Behaviours: A Cross-sectional Study
Authors: Chang Jun-Jie , Xu Nuo , Song Ling-Ling , Li Yong-Han , Yuan Meng-Yuan , Zhang Ting-Ting , He Yang , Chen Shan-Shan , Wang Geng-Fu , Su Pu-Yu
Published: November 2021

BackgroundOverweight and obesity rates have increased rapidly in Chinese school-age children, and previous studies have indicated that poor dietary literacy can lead to poor eating behaviours. However, few studies have investigated the association between the dietary literacy of daily diet providers and the eating behaviours and nutritional status of school-age children raised by the providers. Thus, we aimed to explore this association.MethodsWe collected data on the eating behaviours and nutritional status of children in two primary schools in Anhui Province, as well as the dietary literacy of their daily diet providers. T-tests, one-way ANOVA, and multiple linear regression were used to analyse the association.ResultsWe found significant differences in the scores on the Questionnaire of Children's Daily Diet Providers' Dietary Literacy (QCDDPDL) by region, relationship with the child, age, and educational level of the daily diet provider (all p < .05). Moreover, the children in the low QCDDPDL score group were inclined to engage in unhealthy eating behaviours (p < .05). In addition, the incidence of overweight and obesity was higher in the low QCDDPDL attitude score group than the high score group (p = .006).Conclusions﻿Our study showed that the dietary literacy of diet providers may influence children's health and eating behaviours. Improving the dietary literacy of diet providers may promote the health status and eating behaviours of school-age children.
Fasudil attenuates Neuro-Inflammation and Oxidative Stress via Rhoa/Rock Pathways in Delayed Neuropsychologic Sequelae Mice Model
Authors: Yan Xiang , Fu Meng , Gao Ye , Han Qin , Li Shuang , Xia Huan , Li Jinglun
Published: November 2021

Background

Delayed neuropsychologic sequelae is common in patients after carbon monoxide poisoning without effective methods worldwide. Fasudil exerts neuroprotective effect and alleviates oxidative stress in some neurodegenerative disorders. However, the mechanism between DNS and FS remains unclear. The study aims to explore the efficacy and mechanism of Fasudil in DNS mice model.
Objective

The delayed neuropsychologic sequelae model was induced with a hyperbaric oxygen chamber. All rats were randomly assigned to three groups (n=10): air control group (AC), CO poisoning group (CO), and CO poisoning +Fasudil group (CO+FS). Rats in the CO+FS group were given Fasudil (10 mg/kg/day, ip). The morris water maze was documented to estimate spatial learning and memory of mice. The demyelination state in brain was observed through LFB staining. The protein of MBP was examined with immunofluorescence staining. The levels of IL-6, TNF-α, TGF-β, SOD, and MDA were examined by ELISA. The mRNA levels of Rho, ROCK2, MLC1 and MYPT1 were analyzed by rt-PCR.
Result

The cognitive impairment in the CO+FS group were significantly reduced than those of the CO group (P<0.05). LFB staining and immunofluorescence staining of MBP results showed that FS significantly treatment attenuated demyelination (P<0.05). Compared with the CO group, the levels of TNF-α, IL-6, MDA, ROCK2, MLC1, and MYPT1 significantly decreased (P<0.05), and the levels of SOD were significantly increased in the CO+FS group (P<0.05).
Conclusion

In a word, Fasudil attenuated delayed neuropsychologic sequelae by inhibiting inflammation, oxidative stress and downregulating Rho/ROCK pathway in DNS mice model. We conclude that Fasudil may be a novel treatment for delayed neuropsychologic sequelae.
Effects of TSH Suppressive Therapy On Bone Mineral Density (BMD) and Bone Turnover Markers (BTMs) in Patients with Differentiated Thyroid Cancer in Northeast China: A Prospective Controlled Cohort Study
Authors: Wang Shiwei , Wang Yu , Zhu Li , He Liang , Lv Mutian , Zhang Hao , Wang Haoyu , Zhang Fan , Lai Yaxin , Li Yushu , Shan Zhongyan , Teng Weiping
Published: November 2021

Purpose This study aimed to evaluate the effects of thyroid-stimulating hormone (TSH) suppressive therapy on bone mineral density (BMD) and bone turnover markers (BTMs) in differentiated thyroid cancer (DTC) patients after postoperative 1-2 years in Northeast China. Methods Five male, sixteen premenopausal, and eight postmenopausal female DTC patients receiving TSH suppressive therapy after thyroidectomy were enrolled. Patients were matched with healthy controls in a ratio of 1:2. All participants completed postoperative 1-year follow-up, and postmenopausal women completed 2-year follow-up. We measured BMD of the lumbar spine (LS), femoral neck (FN), and total hip (TH) using dual-energy X-ray absorptiometry (DXA). Bone formation marker P1NP and bone resorption marker β-CTX were also evaluated. Fracture risks were assessed by FRAX. Results There was no difference in BMD and BTMs between DTC patients and controls in the male group at 1-year follow-up. In the premenopausal women, the LS-BMD, FN-BMD, and TH-BMD in DTC patients were all higher than those in controls, but only FN-BMD showed a significant difference. The change rate of P1NP showed a significant difference between DTC patients and controls, while no difference was found in the β-CTX level. In the postmenopausal women, no difference in BMD and BTMs were observed between DTC patients and controls at the 1-year and 2-year follow-up. Conclusion Our study indicated that postoperative 1-year TSH suppressive therapy did not show detrimental effects on BMD and BTMs in men, premenopausal, and postmenopausal DTC patients. The 2-year postoperative TSH suppressive therapy did not lead to additional loss of bone mass in postmenopausal DTC patients.
Integration of Gene Expression Profile Data of Human Epicardial Adipose Tissue From Postoperative Atrial Fibrillation to Verification of Hub Genes
Authors: Cui Yajuan , Wang Xue , Liu Qiang , Gao Wen , Dong Bo
Published: November 2021

Background: The occurrence of post-operative atrial fibrillation (POAF) can significantly reduce the prognosis of patients and increase the mortality of cardiovascular diseases. Meanwhile, epicardial adipose tissue (EAT), plays a crucial role in the occurrence and development of a variety of cardiovascular diseases.Methods: To link EAT with POAF and explore biomarkers with predictive value or therapeutic intervention significance for POAF in EAT.Through the Gene Expression Omnibus (GEO) database, gene expression profiles were collected while GSE 143924 contained EAT from POAF patients and sinus rhythm (SR) patients. And the R package "ClusterProfiler" as well as genetic ontology (GO) and The Kyoto Genomic Encyclopedia (KEGG) were utilized to annotate differential genes and to assess relevant functional categories. Cytoscape was used for protein interaction network (PPI) analysis of the differentially expressed genes. In the end, specimens from clinical patients were collected to further verify the selected genes.Results: The screened differentially expressed genes includes 53 up-regulated genes and 95 down-regulated genes. According to the results obtained by analyzing KEGG, GO enrichment analysis and PPI were made to identify the five genes with the highest degree of connectivity, which includes TNF-α, TLR2, CCL4, TIMP1 and CDH2. Therefore, in peripheral blood samples of clinical POAF patients, CCL4 showed significantly high expression while TIMP1 and CDH2 showed low expression, which was consistent with the results of data screening. But the expression of TLR2 is higher in the POAF group, which is inconsistent with the results of data screening.Conclusion: TNF-α and CCL4 were up-regulated and TIMP1 and CDH2 were down-regulated in EAT with POAF through data analysis and clinical experiments, which features great clinical value for the prevention, diagnosis and treatment of POAF.
Involvement of Ischemia-driven 5LPOX-RvE1-ChemR23 axis in the resolution of post-CABG inflammation in Coronary Arteries
Authors: Thankam Finosh , Wilson Victoria E. D. , Radwan Mohamed M , Siddique Aleem , Agrawal Devendra K
Published: November 2021

Aims: Expression status of pro-resolving lipid mediators (PLM) and receptors in the post-CABG coronary arteries are largely unknown. Here, we aim to investigate the expression of PLMs in the atherosclerotic post-CABG swine LAD compared to without CABG (LAD-AS), and in isolated coronary artery smooth muscle cells (CASMCs) cultured under ischemia. Methodology: The arteries of interest were harvested from post-CABG atherosclerotic swine and the histomorphology and the expression status of key PLM mediators were quantified using immunostaining. SMCs were cultured under ischemia and confirmed the expression on PLM mediators at transcript and protein level.Results: The histomorphometric analysis revealed considerable alterations in the tissue architecture in LAD-CABG and LAD-AS arteries compared to control. PLM synthetic enzyme 5LPOX was significantly upregulated in LAD-CABG and LAD-AS whereas the other mediators including 12LPOX, 15LPOX, COX2, ChemR23, GPCR18, GPCR120 were decreased in LAD-CABG than control. LPOX enzymes and PLM receptors were upregulated in ischemic CASMCs with respect to control. Western blot showed the upregulation of 5LPOX, and ChemR23. Additionally, higher level of RvE1 was observed in ischemic control CASMCs which was decreased following reperfusion. Conclusion: These findings suggest that the CASMCs withstand the ischemia-triggered proinflammatory episodes by increasing the secretion of RvE1 mediated through 5LPOX and ChemR23 signaling.