bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental health assessment of healthcare workers in the Emergency Department of a low middle-income country during COVID 19 pandemic
Authors: Waheed Shahan , Kumar Nirdosh , Qureshi Bushra , Rahim Ahmed
Published: July 2021

Introduction:

Emergency department healthcare workers of Pakistan during COVID 19 pandemic are facing an acute rise of mental illnesses. In the present study, the authors aim to assess the frequency of anxiety and depression among healthcare workers in the emergency department.
Methods:

A cross-sectional online survey was conducted in the emergency department between July to August 2020 at Aga Khan University Hospital Karachi, Pakistan. The Hospital Anxiety and Depression (HAD) scale was used for mental illness assessment among emergency physicians and nurses. Descriptive analysis of grading as per Likert scale is done through frequencies, means and standard deviations. Categorical variables were expressed as frequency (%). Mann-Whitney U test was used to compare scores of various groups and sub-groups and Chi-square test was used to assess the association of depression and anxiety categories among the groups.
Results:

In the emergency department, 127 healthcare professionals (physicians and nurses) were included in this survey. Median depression score was 8 (IQR 6–10) with 21% (27) fall under depression and 39% (50) to borderline depression. Median anxiety score was 9 (IQR 7–12) with 33% (42) had abnormal, 38% (48) had borderline anxiety. Healthcare workers working for > 45 hours per week have odds of 3.62 [1.374–9.549] of developing depression compared to anxiety with a p-value of 0.009. Similarly, nurses and medical officers develop depression with odds of 2.18 [1.016–4.686] p-value 0.045 and 5.18 [0.197–1.02] p-value 0.002, respectively.
Conclusion:

In our study, we determined that healthcare workers working in the Emergency Department during COVID-19 pandemic suffered high levels of anxiety and depression, which is a matter of concern. Therefore, comprehensive support and training of emergency department healthcare providers are paramount to promote physical and mental wellbeing specifically through adequate provision and training on the use of personal protective equipment, strict infection control practices, shorter shift length, and provision of mental health and support services.
Proteome analysis of the Gram-positive fish pathogen Renibacterium salmoninarum reveals putative role of membrane vesicles in virulence
Authors: Kroniger Tobias , Flender Daniel , Schlüter Rabea , Köllner Bernd , Trautwein-Schult Anke , Becher Dörte
Published: July 2021

The bacterial kidney disease (BKD) is a chronic bacterial disease affecting both wild and farmed salmonids. The causative agent for BKD is the Gram-positive fish pathogen Renibacterium salmoninarum. As treatment and prevention of BKD has proven to be difficult, it is important to know and identify the key bacterial proteins that interact with the host. We used subcellular fractionation to report semi-quantitative data for the cytosolic, membrane, extracellular and membrane vesicle (MV) proteome of R. salmoninarum. These data can aid as a backbone for more targeted experiments regarding the development of new drugs for the treatment of BKD. Further analysis was focused on the MV proteome, where both major immunosuppressive proteins P57/Msa and P22 and proteins involved in bacterial adhesion were found in high abundance. Interestingly, the P22 protein was enriched only in the extracellular and MV fraction, implicating that MVs may play a role in host-pathogen interaction. Compared to the other subcellular fractions, the MVs were also enriched in lipoproteins and all four cell wall hydrolases belonging to the New Lipoprotein C/Protein of 60 kDa (NlpC/P60) family were detected, suggesting an involvement in the formation of the MVs.
Heart failure with reduced, mid-range and preserved left ventricular ejection fraction in Chinese with type 2 diabetes: risk factors and prognosis from time of first index hospitalization
Authors: Luk Andrea O.Y , Zhang Xinge , Fung Erik , Wu Hongjiang , Lau Eric S.H , Yang Aimin , Chow Elaine , Kong Alice P.S , Ma Ronald C.W , Chan Juliana C.N
Published: July 2021

BackgroundThe clinical predictors and prognosis of heart failure (HF) by categories of left ventricular ejection fraction (LVEF) have not been well studied in people with diabetes. In a retrospective cohort of Chinese with type 2 diabetes, we examined 1) clinical factors associated with incident decompensated HF, and 2) mortality post-HF, stratified by LVEF.MethodsWe conducted a retrospective analysis of the Hong Kong Diabetes Register comprising 23,348 people with type 2 diabetes without history of HF enrolled between 1993–2015, followed for incident decompensated HF until 2017. Heart failure subtypes were defined according to LVEF on echocardiography. Multivariate Cox proportional hazards models were used to identify clinical factors associated with incident HF versus no HF, stratified by HF subtypes. All-cause mortality rates were compared by HF subtypes.ResultsOver median follow-up of 7.1 years from enrolment, 1,195 (5.1%) people developed decompensated HF. Among 611 (51.1%) people with echocardiography, 24.1% had HF with reduced LVEF (HFrEF) (LVEF < 40%), 15.2% had HF with mid-range LVEF (HFmrEF) (LVEF 41–49%), and 60.7% had HF with preserved LVEF (HFpEF) (LVEF ≥ 50%). Old age, low GFR, albuminuria and coronary artery disease were associated with increased hazards for all HF subtypes. During median follow-up of 2.1 years post-HF, 760 (63.6%) people died. One-year mortality rate was lower in people with HFpEF (16.2%) than those with HFmrEF (vs 26.9%,p = 0.034) and HFrEF (vs 31.3%,p < 0.001). At 10 years, mortality rates in HFpEF group (58.0%) remained lower than HFmrEF group (vs 71.0%,p = 0.38), but similar to HFrEF group (vs 55.8%,p = 0.651).ConclusionsIn Chinese with type 2 diabetes, HFpEF was the predominant HF subtype. One-year mortality following decompensated HF was lowest in HFpEF group but 10-year mortality was similar between HFpEF and HFrEF.
Angioplasty for dysfunctional arteriovenous fistulas: a meta-analysis of recent randomized controlled trials compared paclitaxel-coated balloon versus conventional balloon angioplasty
Authors: Yang Qin , Zhou Yi , Cai Kui , Chen Yufang , Xia Congying
Published: July 2021

Background

Stenosis in arteriovenous fistulas (AVF) due to neointimal hyperplasia is one of the most common causes of hemodialysis vascular access dysfunction. Treating patients with dysfunctional AVF with drug-coated balloon (DCB) angioplasty may potentially improve outcomes. This systematic review aimed to compare the effectiveness and safety of DCB angioplasty versus conventional balloon angioplasty by pooling evidence from the most recent randomized controlled trials.
Methods

We conducted a comprehensive literature search in the Medline, Embase, and Cochrane central databases. Two independent researchers screened the article, extracted interest and evaluated included studies for risk of bias. Pooled estimation was conducted in terms of 6-month target-lesion primary patency (TLPP) and target-lesion reintervention (TLR), as well as other outcomes. Results were expressed with odds ratio (OR) and 95% confidence interval (CI).
Results

A total of 4 RCTs were identified and included in the meta-analyses, with 911 participants. There was no significant increase in rates of 6-month TLPP (OR 1.63, 95%CI 0.39–6.79, p = 0.35), or decrease in 6-month TLR (OR 0.45, 95%CI 0.17–1.19 p = 0.07) in patients who received DCB as compared to those who received conventional balloon angioplasty. Similarly, we found no difference in the 6-month access circuit primary patency and reinvention between the two groups.
Conclusion

There was no evidence supporting that DCB has a statistically significant higher rate of TLPP and lower rates of TLR in the treatment of dysfunctional AVF than conventional balloon angioplasty. However, DCB was non-inferior to conventional balloon angioplasty in terms of safety. Therefore, further study is needed to clarify whether DCB angioplasty can benefit hemodialysis patients with dysfunction AVF.
Fast and noninvasive electronic nose for sniffing out COVID-19 based on exhaled breath-print recognition
Authors: Nurputra Dian Kesumapramudya , Kusumaatmadja Ahmad , Hakim Mohamad Saifudin , Hidayat Shidiq Nur , Julian Trisna , Sumanto Budi , Mahendradhata Yodi , Saktiawati Antonia Morita Iswari , Wasisto Hutomo Suryo , Triyana Kuwat
Published: July 2021

Despite its high accuracy to detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the reverse transcription-quantitative polymerase chain reaction (RT-qPCR) approach possesses several limitations (e.g., the lengthy invasive procedure, the reagent availability, and the requirement of specialized laboratory, equipment, and trained staffs). We developed and employed a low-cost, noninvasive method to rapidly sniff out the coronavirus disease 2019 (COVID-19) based on a portable electronic nose (GeNose C19) integrating metal oxide semiconductor gas sensor array, optimized feature extraction, and machine learning models. This approach was evaluated in profiling tests involving a total number of 615 breath samples (i.e., 333 positive and 282 negative COVID-19 confirmed by RT-qPCR) obtained from 83 patients in two hospitals located in the Special Region of Yogyakarta, Indonesia. Four different machine learning algorithms (i.e., linear discriminant analysis (LDA), support vector machine (SVM), stacked multilayer perceptron (MLP), and deep neural network (DNN)) were utilized to identify the top-performing pattern recognition methods and to obtain high system detection accuracy (88–95%), sensitivity (86–94%), specificity (88–95%) levels from the testing datasets. Our results suggest that GeNose C19 can be considered a highly potential breathalyzer for fast COVID-19 screening.
The Impact and Modelling of Concentrated Butt-Joints on Vertically Laminated Bamboo-Timber Hybrid Bio-Flitch Beams
Authors: Zhang Hexin , Gharavi Niaz , Wong Simon H.F. , Deng Yu , Bahadori-Jahromi Ali , Limkatanyu Suchart , Qiao Yao , Kuang J.S.
Published: July 2021

This paper presents the experimental and analytical studies to investigate the impact of concentrated laminated bamboo butt-joints on the flexural properties of vertically laminated bamboo-timber hybrid beams (VLHBs, or flitch beam). The experimental results reveal that the concentrated butt-joints significantly reduce the flexural strength of the VLHB. They also suggest that the failure mechanism of the VLHBs with or without concentrated butt-joints are completely different. In addition, laminated bamboo lumber with concentrated butt-joints was found to be unsuitable for structural applications. The analytical estimations show close agreement with the experimental results. However, due to the layout of the sample VLHB, the experimental study cannot confirm the impact of the butt-joints on the modulus of elasticity in bending.
Chemical compositions and antioxidant activities of four different mushroom species collected from Turkey
Authors: ŞIHOĞLU TEPE Arzuhan
Published: July 2021

Many researchers agree that edible mushrooms have beneficial effects on human health. The aim of this study is to investigate the chemical composition and antioxidant activities of methanol extracts obtained from Coprinus comatus, Hydnum repandum, Agaricus impudicus ve Sarcodon imbricatus collected from Yuvacık-İzmit, Kastamonu, and Uzungöl-Trabzon. Spectrophotometric analysis showed that the total phenolic (64.69 mg GAEs/g) and flavonoid (1.73 mg QEs/g) content of S. imbricatus was higher than that of the others. In line with its superiority in phytochemical composition analyzes, S. imbricatus extract showed the highest activity in -carotene bleaching, DPPH free radical scavenging and reducing power assays (836.0, 89.0 and 267.0 mg TEs/g extract, respectively). Metal chelating test resulted in the superiority of A. impudicus (1282.0 mg TEs/g). Relative antioxidant capacity index (RACI) value of S. imbricatus was quite high compared to other extracts (0.90). Apart from the metal chelating assay, there was a high correlation between the antioxidant activities of the extracts and their RACI values. Pearson correlation analysis showed that the correlation between the phenolic/flavonoid contents of the extracts and their antioxidant activities was over 0.9. The antioxidant activity of A. impudicus was brought to the literature for the first time with this study. When the data obtained from the current study were evaluated as a whole, it was concluded that S. imbricatus could be a rich source for new and alternative antioxidant compounds.
Didaktičke smjernice za implementaciju kurikuluma međupredmetne teme »Održivi razvoj« u predmetne kurikulume
Authors: Marin Gabrijela
Published: July 2021

Održivi razvoj kao koncept promjena koji je usmjeren stvaranju okruženja u kojemu pojedinac živi u suglasju s prirodom je imperativ kojemu moramo težiti. U posljednjih dvadesetak godina, unatoč zakonskoj regulativi, implementacija tema održivog razvoja u nastavne programe bila je sporadična, prihvaćena od strane ekološki senzibiliziranijih nastavnika, a realizirana najčešće kroz projektne aktivnosti. Iako se kurikularnom reformom održivom razvoju priznala važnost kroz uvođenje međupredmetne teme »Održivi razvoj«, realizacija odgojno-obrazovnih očekivanja je upitna. Upravo konceptualna složenost novoga kurikuluma koja se temelji na interdisciplinarnosti podrazumijeva mnogo širi spektar znanja i vještina od onoga što je jedan nastavnik stekao formalnim obrazovanjem. Cilj je ovoga rada iznijeti pregled najznačajnijih događaja u povijesti obrazovanja za održivi razvoj u Republici Hrvatskoj te na temelju istraživanja hrvatskih i stranih autora izdvojiti didaktičke smjernice koje će nastavnicima olakšati implementaciju novoga kurikuluma u njihovom predmetu, a koje se odnose na izbor sadržaja, korištenje strategija učenja i poučavanja te vrednovanje.
Experiencias corporales de mujeres excombatientes de las FARC-EP. Un análisis de género
Authors: Acevedo Valencia Jenny Marcela , Castaño Torres Stefani , Velásquez Velásquez Ángela María
Published: July 2021

El articulo analiza experiencias de corporeidad de mujeres excombatientes de las FARC-EP, a partir de una investigación sociocrítica, fenomenológica y feminista, que implementó estrategias dialógicas, participativas, contextualizadas y problematizadoras. Los resultados describen los órdenes discursivos insurgentes en torno a la igualdad, los procesos de socialización que moldean cuerpos militantes y a la vez los controlan desde lo normativo; frente a estos últimos se vislumbran prácticas de fuga que evidencian las tensiones entre el orden insurgente y el de la vida civil. Se concluye que el grupo armado moldea una subjetividad que combina elementos de las construcciones de género del contexto campesino de origen y referentes ideológicos y prácticos del contexto bélico que se esfuerza por configurar cuerpos fuertes y disciplinados.
Biodiversity and the Indian Judiciary: Tracing the Trajectory
Authors: Gill G. N. , Chowdhury N. , Srivastava N.
Published: July 2021

The Covid-19 narrative spotlights the necessity to conserve biological diversity (biodiversity) including ecosystems and wildlife. Biodiversity problems are global, and associated governance issues range beyond geographical and spatial boundaries. The globalisation and internationalisation of biodiversity concerns have resulted in the emergence of biodiversity legal frameworks designed to conserve and sustainably use our planet’s biological resources. As an “organic and evolving discipline,” biodiversity laws are increasingly important and affect the Earth’s natural systems that support human life. The article analyses the judicial space that makes, interprets and enforces laws that conserve and support the sustainable use of biodiversity. The proactive, creative judiciary, acting as amicus environment, has produced a major shift in the Indian environmental landscape. The use of public interest litigation (PIL) in both environmental and biodiversity matters is welcomed by the senior judiciary (Supreme Court and High Courts) and also by the specialised environmental tribunal, National Green Tribunal (NGT). The terminological reach of the popular descriptive words, environment, nature and ecology, on occasions including biodiversity, introduced matters litigated in the courts and tribunal. The combination of legal, scientific, and technical expertise in the three judicial fora recognize and consider conservation and protection of biodiversity as an inextricable part of life. The article follows the chronological path of biodiversity litigation, i.e. pre 1992–2002; then 2002–2010 and finally 2010–2020 and examines significant aspects of the three decades of biodiversity litigation.
Rethinking the Education of Multilingual Learners
Authors: Cummins Jim
Published: July 2021

Over the past 40 years, Jim Cummins has originated theories which have had a profound effect on the education of multilingual learners across the world. In this book he traces the development of these theories, and addresses the critiques they have received and their subsequent impact on his thinking and the application of his theories in schools.
The Transformative Materiality of Meaning-Making
Authors: Parkin David
Published: July 2021

This book explores verbal and non-verbal communication from a social anthropological viewpoint, drawing on ethnographic data from fieldwork in eastern Africa. It gives an overview of developments since the 1960s in the anthropology of language use and how these have influenced the author’s thinking.
Зарядоперенос между нейтронно-индуцированным и активаторным центрами в монокристалле LuAG : Pr
Authors: Исламов А.Х. , Ибрагимова Э.М. , Хайитов И.А. , Вильданов Р.Р.
Published: July 2021

Исследованы спектры поглощения, гамма-люминесценции и интегральные кривые термовысвечивания (300-605 K) номинально чистых кристаллов LuAG и активированных ионами празеодима (LuAG : Pr) до и после облучения быстрыми (> 0.1 MeV) нейтронами в интервале флюенсов 1015-1017 cm-2. Оптические спектры LuAG : Pr, облученного флюенсом 1017 cm-2 нейтронов, после термического обесцвечивания до 605 K и последующего 60Со γ-облучения и фотоподсветки в наведенной полосе 573 nm свидетельствуют о переносе электрона от наведенного VО(Cdop)-центра к дырочному Pr4+ с излучением в Pr3+. В случае облучения в суперколлайдере (HL-LHC) быстрыми нейтронами до 5·1015 cm-2 при >300 K локализация электронов на наведенных дефектах F+ и VО(Cdop) и дырок на активаторных Pr4+-центрах приводит к снижению интенсивности быстродействующего (20 ns) активаторного свечения и появлению длительной компоненты в отклике детектора. Ключевые слова: лютеций алюминиевый гранат Lu3Al5O12 : Pr, нейтрон-наведенные дефекты, центры окраски, гамма-индуцированная люминесценция, термовысвечивание, люминесценция.
Electricity, Computing Hardware, and Internet Infrastructures in Health Facilities in Sierra Leone: Field Mapping Study
Authors: Chukwu Emeka , Garg Lalit , Foday Edward , Konomanyi Abdul , Wright Royston , Smart Francis
Published: July 2021

Background

Years of health information system investment in many countries have facilitated service delivery, surveillance, reporting, and monitoring. Electricity, computing hardware, and internet networks are vital for health facility–based information systems. Availability of these infrastructures at health facilities is crucial for achieving national digital health visions.

Objective

The aim of this study was to gain insight into the state of computing hardware, electricity, and connectivity infrastructure at health facilities in Sierra Leone using a representative sample.

Methods

Stratified sampling of 72 (out of 1284) health facilities distributed in all districts of Sierra Leone was performed, factoring in the rural-urban divide, digital health activity, health facility type, and health facility ownership. Enumerators visited each health facility over a 2-week period.

Results

Among the 72 surveyed health facilities, 59 (82%) do not have institutionally provided internet. Among the 15 Maternal and Child Health Posts, as a type of primary health care unit (PHU), 9 (60%) use solar energy as their only electricity source and the other 6 (40%) have no electricity source. Similarly, among the 13 hospitals, 5 (38%) use a generator as a primary electricity source. All hospitals have at least one functional computer, although only 7 of the 13 hospitals have four or more functional computers. Similarly, only 2 of the 59 (3%) PHUs have one computer each, and 37 (63%) of the PHUs have one tablet device each. We consider this health care computing infrastructure mapping to be representative with a 95% confidence level within an 11% margin of error. Two-thirds of the PHUs have only alternate solar electricity, only 10 of the 72 surveyed health facilities have functional official internet, and most use suboptimal computing hardware. Overall, 43% of the surveyed health facilities believe that inadequate electricity is the biggest threat to digitization. Similarly, 16 (22%) of the 72 respondents stated that device theft is a primary hindrance to digitization.

Conclusions

Electricity provision for off-electricity-grid health facilities using alternative and renewable energy sources is emerging. The current trend where GSM (Global System for Mobile Communication) service providers provide the internet to all health facilities may change to other promising alternatives. This study provides evidence of the critical infrastructure gaps in health facilities in Sierra Leone.
Understanding “Internet Plus Healthcare” in China: Policy Text Analysis (Preprint)
Authors: Yang Feng , Shu Huilin , Zhang Xiaoqian
Published: July 2021

BACKGROUND

The combination of the internet and healthcare has excellent benefits and far-reaching positive effects in improving service efficiency and promoting social equity. The role of the “internet plus healthcare” (IPHC) has been recognized, especially during the COVID-19 pandemic. This new healthcare model is also familiar to people and shows a bright prospect.

OBJECTIVE

This article seeks to accurately understand and fully grasp the characteristics of IPHC policies that can enlighten the formulation of future policies.

METHODS

The content analysis method was used to analyze China’s IPHC policies collected from the Beida Fabao database and several official websites.

RESULTS

We found that the development of IPHC policy has gone through 4 stages and is currently entering a phase of rapid development. IPHC policymakers are primarily health administrative departments. In addition, policy instruments are classified into either supply, environment, or demand, and policy themes can be summarized into 4 categories: facilities, technology, service, and management.

CONCLUSIONS

China’s IPHC policy has good prospects from the perspective of development trends. The health administrative departments mainly lead the development of China’s IPHC policy. It is suggested that these departments involve other stakeholders (ie, medical workers, medical industries, and technology sectors) in formulating policies. Policies prefer to use supply-based and environment-based policy instruments. The policy themes emphasize improving infrastructure construction and high-quality diagnostic and treatment services, strengthening the supporting role of information technology, and ensuring all stakeholders understand their responsibilities.
One Decade of Online Patient Feedback: Longitudinal Analysis of Data From a German Physician Rating Website (Preprint)
Authors: Emmert Martin , McLennan Stuart
Published: July 2021

BACKGROUND

Feedback from patients is an essential element of a patient-oriented health care system. Physician rating websites (PRWs) are a key way patients can provide feedback online. This study analyzes an entire decade of online ratings for all medical specialties on a German PRW.

OBJECTIVE

The aim of this study was to examine how ratings posted on a German PRW have developed over the past decade. In particular, it aimed to explore (1) the distribution of ratings according to time-related aspects (year, month, day of the week, and hour of the day) between 2010 and 2019, (2) the number of physicians with ratings, (3) the average number of ratings per physician, (4) the average rating, (5) whether differences exist between medical specialties, and (6) the characteristics of the patients rating physicians.

METHODS

All scaled-survey online ratings that were posted on the German PRW jameda between 2010 and 2019 were obtained.

RESULTS

In total, 1,906,146 ratings were posted on jameda between 2010 and 2019 for 127,921 physicians. The number of rated physicians increased constantly from 19,305 in 2010 to 82,511 in 2018. The average number of ratings per rated physicians increased from 1.65 (SD 1.56) in 2010 to 3.19 (SD 4.69) in 2019. Overall, 75.2% (1,432,624/1,906,146) of all ratings were in the best rating category of “very good,” and 5.7% (107,912/1,906,146) of the ratings were in the lowest category of “insufficient.” However, the mean of all ratings was 1.76 (SD 1.53) on the German school grade 6-point rating scale (1 being the best) with a relatively constant distribution over time. General practitioners, internists, and gynecologists received the highest number of ratings (343,242, 266,899, and 232,914, respectively). Male patients, those of higher age, and those covered by private health insurance gave significantly (P<.001) more favorable evaluations compared to their counterparts. Physicians with a lower number of ratings tended to receive ratings across the rating scale, while physicians with a higher number of ratings tended to have better ratings. Physicians with between 21 and 50 online ratings received the lowest ratings (mean 1.95, SD 0.84), while physicians with >100 ratings received the best ratings (mean 1.34, SD 0.47).

CONCLUSIONS

This study is one of the most comprehensive analyses of PRW ratings to date. More than half of all German physicians have been rated on jameda each year since 2016, and the overall average number of ratings per rated physicians nearly doubled over the decade. Nevertheless, we could also observe a decline in the number of ratings over the last 2 years. Future studies should investigate the most recent development in the number of ratings on both other German and international PRWs as well as reasons for the heterogeneity in online ratings by medical specialty.
Evaluation of patients' satisfaction on booking appointment system in dental school of Isfahan during (Preprint)
Authors: Nilchian Firoozeh , Jamshidian Hamid
Published: July 2021

BACKGROUND

With the development of technology in recent years, booking appointment software systems have gained special and significant popularity among physicians and patients. As Medical university of Isfahan is one of the leading universities of the country the results of this study could be very important for the use of other health systems in different states of country.

OBJECTIVE

This research aimed to assess the patients’ satisfaction of the booking appointment system services of Isfahan dentistry faculty, considering its different types of booking systems and patient satisfaction.

METHODS

The study was descriptive and cross-sectional. The questionnaire was prepared using Zhang study in 2014 and the standard Forward-Backward translation method. In order to investigate the validity, the opinions of the professors of Isfahan Dental School were taken and the professional opinions of the individuals were applied. The questionnaire was distributed among patients referring to the dental school who had undergone the initial examination. After completing the data, SPSS software version 20 and descriptive and analytical statistical tests were used to analyze the data (a = 0.05).

RESULTS

In this study, independent t-test, Kruscal-Wallis test and Pearson correlation test were used to investigate the data. The Kruscal-Wallis test showed that overall satisfaction was significantly higher in patients who booked appointment online than in other patients (P = 0.003). The independent t-test showed that the mean scores of patient satisfaction with staff behavior (P = 0.03) and satisfaction with the waiting time (P = 0.01) were significantly different between native, non-native and passenger patients.

CONCLUSIONS

Most of the people surveyed were generally relatively satisfied with the booking appointment services. Most of them surveyed came in person to queue. Most people cited cheap services as the main reason for their visits. Most people cited telephone busy signal as the reason for not using the telephone booking system.

CLINICALTRIAL

Not require
Information Technology Ambidexterity, Digital Dynamic Capability, and Knowledge Processes as Enablers of Patient Agility: Empirical Study (Preprint)
Authors: van de Wetering Rogier , Versendaal Johan
Published: July 2021

BACKGROUND

There is a limited understanding of information technology’s (IT) role as an enabler of patient agility and the department’s ability to respond to patients’ needs and wishes adequately.

OBJECTIVE

This study aims to contribute to the insights of the validity of the hypothesized relationship among IT resources, practices and capabilities, and hospital departments’ knowledge processes, and the department’s ability to adequately sense and respond to patient needs and wishes (ie, patient agility).

METHODS

This study conveniently sampled data from 107 clinical hospital departments in the Netherlands and used structural equation modeling for model assessment.

RESULTS

IT ambidexterity positively enhanced the development of a digital dynamic capability (β=.69; t4999=13.43; P<.001). Likewise, IT ambidexterity also positively impacted the hospital department’s knowledge processes (β=.32; t4999=2.85; P=.005). Both digital dynamic capability (β=.36; t4999=3.95; P<.001) and knowledge processes positively influenced patient agility (β=.33; t4999=3.23; P=.001).

CONCLUSIONS

IT ambidexterity promotes taking advantage of IT resources and experiments to reshape patient services and enhance patient agility.
Quality of life problems in children with juvenile idiopathic arthritis and its subtype associated with uveitis (literature review and own research)
Authors: Bogmat L.F. , Fadieieva A.A. , Shevchenko N.S.
Published: July 2021

Background. The problem of the quality of life (QoL) is relevant nowadays, especially for patients with chronic diseases, including juvenile idiopathic arthritis (JIA) and the subtype of JIA associated with uveitis (JIA-u). The purpose was to carry out a literature review on the QoL in children with JIA and JIA-u, with an analysis of existing tools, the possibility of their use in children, and to assess the QoL indicators of children with JIA, who were treated in a specialized department of the hospital. Materials and methods. The search was performed in the PubMed, Medline, and Google databases using the keywords: JIA, rheumatoid arthritis, uveitis, JIA-u, arthritis with uveitis, QoL, QoL in children. Inclusion criteria were as follows: publication after 2010, use of questionnaires to assess QoL, the sample of patients over 30 people. The type of instrument for assessing QoL, the sample nature, and the QoL indicators of patients were analyzed. The study was carried out at the premises of the State Institution “Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine” and involved 41 children with JIA (22 with polyarticular, and 19 with oligoarticular variants): 25 girls and 16 boys aged 3–17 years with disease duration of 40.2 ± 6.2 months. Thirty-six of them received methotrexate, and 5 — sulfasalazine. The disease activity was assessed by the Juvenile Arthritis Disease Activity Score (JADAS27) and the functional state — by the Childhood Health Assessment Questionnaire (CHAQ). For quality of life assessment, the Pediatric Quality of Life InventoryTM validated for Ukraine was used. Results. The analysis included 73 foreign scientific papers from 2011 to 2021, among which 11 are fully devoted to the assessment of QoL in children with JIA, and 62 partially cover this topic in children and adults with arthritis. In Ukraine, these issues are not discussed enough (6 articles on the evaluation of QoL in children), the factors for its deterioration remain unclear. The level of activity according to JADAS27 in children in subgroups with both poly- and oligoarticular variants was high (11.20 ± 7.04 and 8.9 ± 4.2 points), and the functional state (on CHAQ) — 0.19 ± 0.17. In children with JIA, QoL indicators are reduced, especially on the scales of emotional and school functioning, and closely correlate with disease activity (r = 0.784, p < 0.05). Conclusions. The analysis of the conducted studies showed that decreased disease activity is not accompanied by the QoL indicators optimization, which remain reduced. Recently, the situation with the QoL assessment in domestic medicine has been improving, relevant questionnaires are being actively introduced. However, the ambiguity of the results in world medicine and the presence of a small number of works on this topic determine the urgency of the problem of QoL in children with JIA in Ukraine.
Dynamics of inflammatory changes of the gastric mucosa in children with duodenal ulcer
Authors: Sorokman T.V. , Moldovan P.M. , Khlunovska L.Yu. , Lozyuk I.Ya.
Published: July 2021

Background. The problem of gastrointestinal diseases in children remains quite relevant due to the high prevalence and presence of atypical symptoms and comorbidities pathogenetically associated with acid-dependent diseases. The purpose was to study the dynamics of inflammatory changes of the mucous membrane in children with duodenal ulcer (DU). Materials and methods. One hundred and six children aged 10 to 18 years with DU were examined. To verify the diagnosis, all children underwent endoscopy, pH-metry, morphological examination of gastrobiopsy samples, examination for Helicobacter pylori (H.pylori). Results. 49.1 % of children with DU were diagnosed with impaired motor-evacuatory function in the form of duodenogastric and/or gastrooesophageal reflexes, 81.1 % of patients presented with H.pylori was determined. Erythematous changes of the gastric and duodenal mucosa predominated. 92.4 % of patients were diagnosed with chronic non-atrophic gastritis and/or gastroduodenitis with varying degrees of inflammation, 7.6 % of children — chronic atrophic gastritis. There was a decrease in height and signs of desquamation of the superficial epithelium, in 72.3 % — the development of granular dystrophy, in 6.9 % of patients without H.pylori infection and in 57.5 % of H.pylori infected — neutrophilic infiltration of the mucous membrane. In the dynamics after 3 months, the height of the superficial epithelium and the frequency of desquamative changes decreased, and the proliferation of the glandular epithelium 12.4 % increased. Conclusions. Morphological changes in biopsies of the gastric mucosa differ depending on the presence of H.pylori infection and partially persist for 3 months after treatment.
The problem of dehydration in pediatrics
Authors: Kramarov S.O. , Yevtushenko V.V. , Yevtushenko О.М. , Maevska Ye.A. , Babak V.V.
Published: July 2021

Dehydration syndrome often complicates the course of various diseases in children. The article covers the main pathological conditions that are accompanied by fluid loss, such as infectious diarrhea, cyclic vomiting syndrome, non-diabetic ketosis and ketoacidosis. The pathophysiological mechanisms that lead to water and electrolyte loss are described, as well as methods for correcting dehydration in pediatrics. We presented the results of a clinical study of Reogel, which was used for oral rehydration in children with acute infectious diarrhea receiving inpatient treatment. According to the results of this observation, we did not find a significant difference in the duration of the main clinical symptoms of the disease, such as diarrhea, vomiting and dehydration symptoms, as well as the frequency and duration of parenteral rehydration between groups of children receiving Reogel and standard oral rehydration. The results of this study give grounds to consider Reogel as an alternative to traditional oral rehydration in children with infectious diarrhea, accompanied by mild and moderate dehydration.
Regulation of miRNA content. Part 1. Editing miRNA. Тailing miRNA
Authors: Abaturov A.E. , Babуch V.L.
Published: July 2021

This scientific review presents the processes of regulation of miRNA content. To write the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library, CyberLeninka databases. The article presents the characteristics of the processes of microRNA editing and microRNA tailing, which regulate the content of microRNA through the transcription control. It is emphasized that editing is the most important mechanism of posttranscriptional regulation of microRNA that occurs with the help of RNA-specific adenosine deaminase. The article shows that editing leads to a change in the secondary structure of the microRNA molecule and the deviation of the process of microRNA maturation. It is shown that microRNA tailing is a posttranscriptional elongation of the tail of the molecule by adding nucleotides to the 3’-end of RNA. It has been found that uridinylation is a very common posttranscriptional process that regulates gene expression. The effect of uridinylation on microRNA biogenesis has been demonstrated on the example of the miR let-7 family, which inhibits proliferation and promotes cell differentiation. It has been established that another type of microRNA tailing, namely adenylation, most often contributes to the stabilization of the molecule, but in some cases can lead to microRNA degradation. Thus, the regulation of miRNA content is carried out by editing miRNA, microRNA tailing. Due to editing, the secondary structure of the microRNA molecule changes and the microRNA maturation process deviates. MicroRNA tailing is a post-transcriptional elongation of the tail of the molecule by adding nucleotides to the 3’-end of RNA by polyuridinylation or polyadenylation. Uridinylation affects the processing and degradation of miRNA precursors with different molecular effects, which in some cases contribute to the development of diseases.
Сlinical and laboratory features of Reye’s syndrome in children: a clinical case
Authors: Koloskova O.K. , Tkachuk R.V. , Bilous T.M. , Kolyubakina L.V. , Bogutska N.K.
Published: July 2021

Reye’s syndrome is a very rare disease that occurs in the pediatric population with a frequency of approximately 6 cases per 100,000 children, but the mortality due to this nosology is quite high and depends on its severity and prognostic factors. This pathology should be a warning for practitioners in terms of diagnosis and timely precautions for possible progression of the disease, taking into account the high mortality rate, the rapid progression of neurological symptoms, and lack of clear predictors of Reye’s syndrome. The article presents modern views on the etiology, pathogenesis, clinical course, laboratory and morphological diagnosis of Reye’s syndrome. Recommended by the Center for Disease Control and Prevention in Atlanta criteria for the diagnosis of Reye’s syndrome are given in the article. The article describes the differential diagnosis between classical (aspirin-associated, idiopathic) and atypical Reye’s syndrome (Reye’s-like syndrome), as well as focuses on a set of diagnostic and therapeutic measures. A clinical case of the classic Reye’s syndrome in pediatric practice is presented, which occurred in the Regional Municipal Non-Profit Enterprise “Chernivtsi Regional Children’s Clinical Hospital”. The presented clinical case, unfortunately, was fatal and the body was subjected to an autopsy, the results of which, as well as morphological changes in the section material after specific staining with Sudan III, are also described in the article. The review of the case ends with a summary and conclusions, authors emphasize the need to draw the attention of practitioners to the possibility of developing rare Reye’s syndrome in children after the use of acetylsalicylic-containing drugs; for the verification of nosology, a doctor should take into account specific changes in clinical and paraclinical parameters, and due to the absence of a minimum permitted dose of acetylsalicylic acid it should be prohibited for use in pediatric practice as an antipyretic drug.
Humanism in Norman Mailer's War Novels
Authors: Lateef Dr. Wisam Hamid
Published: July 2021

The justification for undertaking this study lies in presenting a compact picture of war themes in the novels of Norman Mailer. He feels that war can give men an opportunity to encounter an essential human condition in which an individual must call upon his deepest resources to survive. He is always conscious of his death. He feels that life is war. The Second World War presents a mirror to the human condition, which blinded anyone who looked into it. The method of searching the theme has been analytical. This paper is based on his novel, The Naked and the Dead, a traditional and symbolic novel, crystallizes the evil of War. It is the best war novel after the Second World War. Mailer's other War novel, An American Dream, is a catalogue of the conflicts. The novel presents the vision of hope for individual salvation and spiritual growth. It shows that war dehumanizes man and brings disaster of every kind.
formulação de política pública de preservação do patrimônio pelo parlamento brasileiro
Authors: Ribeiro Adriano da Silva
Published: July 2021

Resenha do livro O poder legislativo no desenho institucional da política de preservação do patrimônio cultural no Brasil de Mila Batista Leite Corrêa da Costa.
Resource-Optimized Fermionic Local-Hamiltonian Simulation on a Quantum Computer for Quantum Chemistry
Authors: Wang Qingfeng , Li Ming , Monroe Christopher , Nam Yunseong
Published: July 2021

The ability to simulate a fermionic system on a quantum computer is expected to revolutionize chemical engineering, materials design, nuclear physics, to name a few. Thus, optimizing the simulation circuits is of significance in harnessing the power of quantum computers. Here, we address this problem in two aspects. In the fault-tolerant regime, we optimize the Rz and T gate counts along with the ancilla qubit counts required, assuming the use of a product-formula algorithm for implementation. We obtain a savings ratio of two in the gate counts and a savings ratio of eleven in the number of ancilla qubits required over the state of the art. In the pre-fault tolerant regime, we optimize the two-qubit gate counts, assuming the use of the variational quantum eigensolver (VQE) approach. Specific to the latter, we present a framework that enables bootstrapping the VQE progression towards the convergence of the ground-state energy of the fermionic system. This framework, based on perturbation theory, is capable of improving the energy estimate at each cycle of the VQE progression, by about a factor of three closer to the known ground-state energy compared to the standard VQE approach in the test-bed, classically-accessible system of the water molecule. The improved energy estimate in turn results in a commensurate level of savings of quantum resources, such as the number of qubits and quantum gates, required to be within a pre-specified tolerance from the known ground-state energy. We also explore a suite of generalized transformations of fermion to qubit operators and show that resource-requirement savings of up to more than 20%, in small instances, is possible.
Technology-Enhanced Course in English Theoretical Grammar and Phonetics at Tertiary Level
Authors: Kuzmina Jana , Vinčela Zigrīda
Published: July 2021

The advancement of technologies and the recently forced lockdown by Covid-19 are bringing changes to the organisation of the learning process by accelerating the introduction of e-learning to create a learner-centred technology-based approach to English studies, thus stepping towards digital humanities. These trends initiated the institutional project Mobile and Desktop Software Integration in Bachelor and Master Study Programmes. The present study, using a questionnaire, elicits university students’ attitudes to the mobile applications and speech analysis software-based seminar activities in Moodle e-course in accordance with the blended learning model selected for the studies of theoretical grammar and phonetics. It is a cross-sectional, focused, and exploratory case study, comprising a description of factors, contributing to the problem of blended learning model selection. The yielded data demonstrate that students do not possess extensive prior experience with the use of software and mobile applications to study English grammar and phonetics. After completing seminar tasks, they favourably account for the integrated blended learning materials and consider that those facilitate their learning process.
From Defoe to Coetzee’s Foe/Foe through Authorship
Authors: Suciu Andreia Irina , Culea Mihaela
Published: July 2021

The article investigates the concept of authorship in the works of two authors separated by three centuries, namely, Daniel Defoe and J. M. Coetzee, both concerned, in different ways, with aspects regarding the origin and originators of literary works or with the act of artistic creation in general. After a brief literature review, the article focuses on Coetzee’s contemporary revisitation of the question of authorship and leaps back and forth in time from Defoe’s Robinson Crusoe (1719) to Coetzee’s Foe (1986). The purpose is that of highlighting the multiple perspectives (and differences) regarding the subject of authorship, including such notions and aspects as: canonicity related to the act of writing and narrating, metafiction, self-reflexivity and intertextuality, silencing and voicing, doubling, bodily substance and the substance of a story, authenticity, (literary) representation and the truth, authoring, the author’s powers, the relation between author and character or between narrator and story, authorial self-consciousness, agency, or ambiguity. The findings presented in the article show that both works are seminal in their attempts to define and redefine the notion of authorship, one (Defoe) concerned with the first literary endeavours of establishing the roles of professional authorship in England, while the other (Coetzee), intervenes in existing literary discussions of the late twentieth century concerning the postmodern author and (the questioning of or liberation of the text from) his powers.
Improving the Competitiveness of Russian Universities and the Role of State Programs in the Development of Higher Education
Authors: Gertsik Yu. G. , Moskovkin V. M.
Published: July 2021

The project aimed to increase the competitiveness of Russian universities among the world’s leading research and educational centers, which was called “5–100”, was completed in 2020. The aim of this project assumed the entry of five Russian universities into the TOP 100 world institutional rankings. However, due to the fact that there are currently a large number of international rankings among higher education institutions, both global and industry-specific or subject-specific, the indicators achieved within the framework of the “5–100” project are still being discussed by the expert community. For the further effective implementation of the national project “Science“ in terms of achieving the priority state development goals in the field of science and education, it is important to formulate proposals and mechanisms for realization the strategic academic leadership program” Priority-2030“ on the basis of available data and the results of the analysis of the experience gained, which are presented in this paper.