bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multi-Material Additive Manufacturing virtual prototyping method for design to improve part strength
Authors: Kakaraparthi Shivaram , Chen Niechen
Published: January 2023

Multi-Material Additive Manufacturing (MMAM) offers new opportunities to realize components with more integrated features and functionalities in reduced manufacturing costs by eliminating assembly processes. However, the weak mechanical bond between different materials often results in unexpected weakness sections that reside around the multi-material boundary interface. Thus, strengthening the boundary interface is critical to enabling the wide application of MMAM processes in production. Our work approaches this challenge by introducing a new virtual prototyping method to strengthen MMAM parts by facilitating the design and planning process. In our work, a computational part strength prediction model is built, and this model is used to quickly and realistically predict the mechanical strength of a part design within the context of its manufacturing plan. This enables fast iteration of redesigns to create parts that can be directly printed with improved strength. Compared to the commonly used Design of Experiment-based approaches, this new virtual prototyping method offers a more time and cost-efficient solution that delivers better designs in a shorter design cycle and with no material wastage by eliminating the need for physical test printing.
Therapeutic potential of hesperidin: Apoptosis induction in breast cancer cell lines
Authors: ONDER Gozde Ozge , GOKTEPE Ozge , BARAN Munevver , BITGEN Nazmiye , AYDIN Funda , Yay Arzu
Published: January 2023

Purpose
Hesperidin is a flavonoid commonly found in citrus fruits. Studies have shown that hesperidin has anti-inflammatory, analgesic, and antimicrobial properties, as well as its effectiveness in carcinogenesis. In this paper, we aim to investigate the molecular mechanisms of hesperidin-induced apoptosis in MCF-7 and MDA-MB-231 cancer cells.
Methods
Hesperidin’s 50% inhibitory concentrations in the cells were evaluated by the MTT assay. Cell cycle analysis of hesperidin-treated cells was then performed, as well as immunocytochemical analysis of the effect on the apoptosis pathway (TUNEL, Bax, and Bcl-2 expression).
Results
Moreover, hesperidin induced cell apoptosis in MCF-7 breast cancer cells by inhibiting Bcl-2 and enhancing Bax expression at protein levels. On the other hand, hesperidin caused apoptosis in the MDA-MB-231 breast cancer cell line, but it did not activate the Bax/Bcl-2 pathway. Hesperidin also induced cell cycle arrest at the S phase in the MCF-7 and MDA-MB-231 cell lines.
Conclusion
These findings showed that hesperidin is a potential therapeutic candidate for preventing the progression of breast cancer. In addition, hesperidin could significantly stimulate the death mechanisms in ER/PR (+) MCF-7 cells by changing the expression balance of Bax and Bcl-2 proteins, but lead ER/PR (-) MDA-MB-231 breast cancer cells to apoptosis in a different way.
How Personality Influences Health Outcomes and Quality of Life in Adult Patients with Cystic Fibrosis
Authors: Niehammer Ute , Straßburg Svenja , Sutharsan Sivagurunathan , Taube Christian , Welsner Matthias , Stehling Florian , Hirtz Raphael
Published: January 2023

Background: The present study evaluates personality traits in adult patients with cystic fibrosis (CF) and correlates these results with health-related quality of life (HRQoL) and other clinical parameters indicative of disease severity.
Methods: Seventy adults completed the Cystic Fibrosis Questionnaire-Revised (CFQ-R +14), a CF-specific measure of HRQoL, and a self-administered questionnaire about personality traits and disorders. Mean subscale scores and the prevalence of extreme personality traits on the `Persönlichkeits-Stil- und Störungs-Inventar (PSSI)´ were compared to the norming sample. Moreover, a cluster analysis was conducted to identify personality styles among people with cystic fibrosis (pwCF). The relationship between mean PSSI subscale scores and personality clusters with HRQoL and clinical outcomes, e.g., percent predicted forced expiratory volume in one second (ppFEV1), and body mass index (BMI), was studied by regression analysis considering important confounders.
Results: On several of the subscales of the personality questionnaire, people with cystic fibrosis (pwCF) showed either significantly higher or lower scores than the norm sample. In further analyses, two personality clusters could be identified. PwCF from the cluster with predominantly low scores on the subscales `negativistic´, `schizoid´, `borderline´, `depressed´, and `paranoid´ showed better HRQoL than pwCF from the other cluster with mainly high normal or elevated scores. The studied health outcomes proved to be independent of the respective personality clusters.
Conclusions: In pwCF, HRQoL is mainly determined by psychological factors, including personality. Since more recent personality theories assume that personality is modifiable, our findings imply that patients with accentuated personality traits may benefit from psychosocial support.
The prognostic value of the NECPAL instrument, Palliative Prognostic Index, and PROFUND index in elderly residents of nursing homes with advanced chronic condition
Authors: Esteban-Burgos Ana Alejandra , Hueso-Montoro César , Mota-Romero Emilio , Montoya-Juárez Rafael , Gómez-Batiste Xavier , García-Caro María Paz
Published: January 2023

Background: It is essential to assess the need for palliative care and the life prognosis of elderly nursing home residents with an advanced chronic condition, and the NECPAL ICO-CCOMS©4.0 prognostic instrument may be adequate for both purposes. The objective of this study was to examine the predictive capacity of NECPAL, the Palliative Prognosis Index, and the PROFUND index in elderly residents with advanced chronic condition with and without dementia, comparing their results at different time points.
Methods: This prospective observational study was undertaken in eight nursing homes, following the survival of 146 residents with advanced chronic condition (46.6% with dementia) at 3, 6, 12, and 24 months. The capacity of the three instruments to predict mortality was evaluated by calculating the area under the receiver operating characteristic curve (AUC), with 95% confidence interval, for the global population and separately for residents with and without dementia. Results: The mean age of residents was 84.63 years (±8.989 yrs); 67.8% were female. The highest predictive capacity was found for PROFUND at 3 months (95%CI: 0.526-0.756; p=0.016), for PROFUND and NECPAL at 12 months (non-significant; AUC >0.5), and NECPAL at 24 months (close-to-significant (AUC=0.624; 95% CI: 0.499-0.750; p=0.053). The highest capacity at 12 months was obtained using PROFUND in residents with dementia (AUC=0.698; 95%CI: 0.566-0.829; p=0.003) and NECPAL in residents without dementia (non-significant; AUC=0.649; 95%CI: 0.432-0.867; p=0.178). Significant differences in AUC values were observed between PROFUND at 12 (p=0.017) and 24 (p=0.028) months. Conclusions: PROFUND offers the most accurate prediction of survival in elderly care home residents with advanced chronic condition overall and in those with dementia, especially over the short term, whereas NECPAL ICO-CCOMS©4.0 appears to be the most useful to predict the long-term survival of residents without dementia. These results support early evaluation of the need for palliative care in elderly care home residents with advanced chronic condition.
Analysis about the Continuous Participation Behavior of Dance for All Participants during the COVID-19 Pandemic by applying the Extended Health Belief Model
Authors: An Jung-Hun , Lim Sun-Young , Lee Ji-Seol
Published: January 2023

Background: Based on EHBM theory, this study added the concepts of DFAP’s attitudes toward COVID-19 and perceived behavior control to the main components perceived susceptibility, perceived benefit, and perceived barriers. In addition, these factors intended to verify the continuous behavioral intention of physical activity through DFA by empirically analyzing the influence relationship of the EHBM by CA into media information exposure and personal information exposure for COVID-19.
Methods:A survey was conducted on DFAP’s 665, who joined public sports facilities, academies, and clubs in Seoul and Gyeonggi Province in South Korea from August 2020 to February 2022. Data analysis was performed on Windows PC/SPSS 26.0 and AMOS 24.0 ver. frequency analysis, correlation analysis, confirmatory factor analysis and structural equation modeling were used to analyze the survey results.
Results:First, PB a sub-factor of the EHBM of have a statistically significant (p<0.05) effect on CPB. Second, the sub-factors of EHBM, CA and AT, have a statistically significant (p<0.001) effect on CPB. Third, PBC have a statistically significant (p<0.001) effect on CPB.
Conclusions:The results derived in the process of achieving this purpose are academically meaningful in that they present the direction of DFA activation in the 'New Normal Era' provide practical implications for related workers.
Transcription factor PRDM15 binds to the promoter mutation locus of PPP2R5C promoted proliferation of goat granulosa cells
Authors: Wang Peng , Li Wentao , Liu Ziyi , He Xiaoyun , Liu Yufang , Chu Mingxing
Published: January 2023

Protein phosphatase 2 regulatory subunit B’gamma (PPP2R5C) is involved in a variety of physiological processes in mammals, such as growth and development, cellular metabolism, and immunity. Here, the PCR sequencing and KASP genotyping sequencing were used to detect the distribution of SNPs of PPP2R5C, and then a series of molecular biology technology were used to detect the regulation pathway between PPP2R5C and kidding number trait of goats. The sequencing results showed that there was a g.65977460A > G mutation locus in the promoter region of PPP2R5C, and there were 223 individuals with genotype GG, 91 with genotype GA, and 51 with genotype AA in the tested population of Yunshang black goats. Association analysis showed that the kidding number trait of second and third parity were significantly higher for the individuals with AA genotype than those with the AG and GG genotypes. Subsequently, the results of dual luciferase activity assay showed that the promoter activity of PPP2R5C-mutant-A was significantly higher than that of PPP2R5C-Wild-G (P < 0.05). The transcription factor PRDM15 was predicted to bind to a mutation in PPP2R5C (g.65977460A > G). The results of ChIP-qPCR showed that the transcription factor PRDM15 could bind to the promoter region of PPP2R5C. Moreover, the expression of PPP2R5C, proliferation factors CDK4 and Cyclin-D2 in goat GCs was significantly increased after PRDM15 (PR/SET domain 15) overexpression (P < 0.05). While the results of EdU and CCK-8 showed that the proliferation rate of goat GCs increased after PRDM15 overexpression and the proliferation efficiency of goat GCs was significantly reduced after PRDM15 inhibition (P < 0.05).Finally, the expression of the PI3K-Akt pathway (phosphatidylinositol-3-kinase/protein kinase B) marker AKT2 (AKT serine/threonine kinase 2) was significantly increased in granulosa cells overexpressing PRDM15, and the opposite was true after inhibition of PRDM15. Together, our results showed that PPP2R5C g.65977460A > G was significantly associated with the kidding number in Yunshang black goats. The transcription factor PRDM15 was identified to bind to the promoter region of PPP2R5C g.65977460A > G mutation locus promoted the proliferation of goat granulosa cells (GCs) by the PPP2R5C/PI3K-Akt pathway. These results provide a new insight into the molecular mechanisms underlying the phenotypic changes in goats.
OsWRKY76 positively regulates drought stress via OsbHLH148-mediated jasmonate signaling in rice
Authors: Zhang Mingxing , Zhao Ranran , Huang Kai , Wei Zhiqi , Guo Boya , Huang Shuangzhan , Li Zhao , Jiang Wenzhu , Wu Tao , Du Xinglin
Published: January 2023

Drought stress is a major environmental threat that limits plant growth and crop productivity. Therefore, it is necessary to uncover the molecular mechanisms behind drought tolerance in crops. Here, OsWRKY76 positively regulated drought stress in rice. OsWRKY76 expression was induced by PEG treatment, dehydration stress, and exogenous MeJA rather than by no treatment. Notably, OsWRKY76 knockout weakened drought tolerance at the seedling stage and decreased MeJA sensitivity. OsJAZ12 was significantly induced by drought stress, and its expression was significantly higher in OsWRKY76-knockout mutants than in wild-type ZH11 under drought stress. Yeast two-hybrid and bimolecular fluorescence complementation assays showed that OsWRKY76 interacted with OsJAZ12. OsWRKY76 weakened the interaction between OsbHLH148 and OsJAZ12 in yeast cells. The OsJAZ12 protein repressed the transactivation activity of OsbHLH148, and this repression was partly restored by OsWRKY76 in rice protoplasts. Moreover, OsDREB1E expression was lower in OsWRKY76-knockout mutants than in wild-type ZH11 under drought stress, but it was upregulated under normal growth conditions. Yeast one-hybrid, electrophoretic mobility shift, and dual-luciferase assays showed that OsWRKY76 and OsbHLH148 bound directly to the OsDREB1E promoter and activated OsDREB1E expression in response to drought stress. These results suggest that OsWRKY76 confers drought tolerance through OsbHLH148-mediated jasmonate signaling in rice, offering a new clue to uncover the mechanisms behind drought tolerance.
The Vladimirov-Taibleson Operator: Inequalities, Dirichlet Problem, Boundary H\"older Regularity
Authors: Kochubei Anatoly
Published: January 2023

We study the Vladimirov-Taibleson operator, a model example of a pseudo-differential operator acting on real- or complex-valued functions defined on a non-Archimedean local field. We prove analogs of classical inequalities for fractional Laplacian, study the counterpart of the Dirichlet problem including the property of boundary H\"older regularity of solutions.
MSC 2020. Primary: 35S05. Secondary: 11S80, 47G30, 35S11; 35R11.
Appendicitis and peritonitis in children with a ventriculo-peritoneal shunt
Authors: Fröschle Glenn M C , Hagens Johanna , Mannweiler Philip , Groth Friederike Sophie , Kammler Gertrud , Reinshagen Konrad , Tomuschat Christian
Published: January 2023

Purpose:
The purpose of this study was to outline the management of patients with appendicitis and ventriculoperitoneal shunt (VPS).
Methods:
Patients with VPS presenting with an acute abdomen between 2012 and 2022 at a tertiary-care pediatric facility were the subject of a descriptive analysis. Patients were divided into two groups based on their diagnoses: group A (appendicitis) and group B (primary peritonitis). Medical records were analyzed to look at the diagnostics, operative approach, complications, peritoneal and liquor culture and antibiotic treatment.
Results:
A total of 17 patients were examined: 7 patients in group A and 10 individuals in group B. In the present study patients in group A typically present younger, sicker, and with more neurological symptoms than those in group B. All patients with appendicitis had their VPS exteriorized and a new shunt system into the peritoneum reimplanted 20 days later.
Conclusion
Surgery should be aggressively administered to patients who present with an acute abdomen and a VPS. In those with evident perforation, change of the whole shunt system is suggested. Shunt infection and dysfunction should be ruled out in patients with abdominal symptoms, and surgical care should be started with a low threshold.
High-tech equipment configuration and management policy assessment: An equity and efficiency analysis of MRI services in Henan province, China
Authors: Huang Xiaoling , Wei Yan , Sun Hui , Huang Jiaqi , Chen Yingyao , Cheng Jingliang
Published: January 2023

Background: By evaluating equity and effectiveness, this study provides evidence-based knowledge for scientific decision-making and the optimization of magnetic resonance imaging (MRI) configuration and utilization at the provincial level.
Methods: Using data of 2017, we apply a Gini coefficient to analyze the equity of MRI services in 11 sample cities in Henan province. An agglomeration degree is then applied to measure equity from the perspective of population and geography, and a data envelope analysis is used to evaluate MRI efficiency.
Results: The overall Gini coefficient of MRI allocation by population in the 11 sample cities is 0.117; however, the equity varies considerably among the sample cities. The sample’s comprehensive efficiency is only 0.732, indicating the overall ineffectiveness of provincial MRI utilization. The pure technical and scale efficiency of four sample cities are both below 1, indicating lower MRI effectiveness than the rest.
Conclusions: Although the overall equity of configuration at the provincial level is relatively good, equity varies at the municipal level. Our results show a low MRI utilization efficiency, which policymakers should consider carefully during policy implementation.
Evaluation of community-based vector surveillance system for routine entomological monitoring under low malaria vector densities and high bednet coverage in western Kenya
Authors: Abong’o Bernard , Stanton Michelle C. , Donnelly Martin J. , Ochomo Eric , Kuile Feiko O. ter , Samuels Aaron M. , Kariuki Simon , Musula George , Oxborough Richard , Munga Stephen , Torr Steve J. , Gimnig John E.
Published: January 2023

Introduction. Entomological surveillance is traditionally conducted by supervised teams of trained technicians. However, it is expensive and limiting in the number of sites visited. Surveillance through community-based collectors (CBC) may be more cost-effective and sustainable for longitudinal entomological monitoring. This study evaluated the efficiency of CBCs in monitoring mosquito densities compared to quality-assured sampling conducted by experienced entomology technicians.
Methodology. Entomological surveillance employing CBCs was conducted in eighteen clusters of villages in western Kenya using indoor and outdoor CDC light traps and indoor Prokopack aspiration. Sixty houses in each cluster were enrolled and sampled once every month. Collected mosquitoes were initially identified to the genus level by CBCs, preserved in 70% ethanol and transferred to the laboratory every two weeks. Parallel, collections by experienced entomology field technicians were conducted monthly by indoor and outdoor CDC light traps and indoor Prokopack aspiration and served as a quality assurance of the CBCs.
Results. Per collection, the CBCs collected 80% fewer An. gambiae s.l. [RR=0.2; (95%CI: 0.14 – 0.27)] and An. coustani [RR=0.2; (95%CI: 0.06-0.53)] and 90% fewer An. funestus [RR=0.1; (95%CI: 0.08-0.19)] by CDC light traps compared to the quality assured (QA) entomology teams. Significant positive correlations were however observed between the monthly collections by CBCs and QA teams for both An. gambiae and An. funestus. In paired identifications of pooled mosquitoes, the CBCs identified 4.3 times as many Anophelescompared to experienced technicians. The cost per person-night was lower in the community-based sampling at $9.1 compared to $89.3 by QA per collection effort.
Conclusion. Unsupervised community-based mosquito surveillance collected substantially fewer mosquitoes per trap-night compared to quality-assured collection by experienced field teams, while consistently overestimating the number of Anophelesmosquitoes during identification. However, the numbers collected were significantly correlated between the CBCs and the QA teams suggesting that trends observed by CBCs and QA teams were similar. Further studies are needed to evaluate whether adopting low-cost, devolved supervision with spot checks, coupled with remedial training of the CBCs, can improve community-based collections to be considered a cost-effective alternative to surveillance conducted by experienced entomological technicians.
Targeted-Gene Sequencing and Bioinformatics Analysis of Patients with Gallbladder Neuroendocrine Carcinoma: A Case Report and Literature Review
Authors: Yang Yunchuan , Chen Zhitao , Tang Hui , Wan Dalong , Liu Mulin
Published: January 2023

Background: Gallbladder Neuroendocrine carcinomas (NEC) is a subtype of gallbladder malignant tumour that is characterized by low incidence, high malignancy and poor prognosis. To date, the genetic alterations, mechanistic relationships among mutated genes and signaling pathways of gallbladder NEC are unclear.
Patient and Methods: This paper presents a case of rare primary gallbladder NECin a 73-year-old female patient. A radical cholecystectomy associated with hepatic hilar lymphadenectomy, resection of segments IV-B and V of the liver were performed. Targeted-gene sequencing and bioinformatics analysis tools, including STRING, GeneMANIA, Metascape, TRRUST, Sangerbox, cBioPortal and GSCA, are used to clarify the biological functions and features of mutated genes in gallbladder NEC.
Results: Twelve gene mutations (APC, ARID2, IFNA6, KEAP1, RB1, SMAD4, TP53, BTK, GATA1, GNAS and PRDM3) were observed, and a tumor mutation burden (TMB) of 9.52 muts/Mb was calculated in the gallbladder NEC using targeted-gene sequencing. Protein-protein interaction network was constructed, which showed the significant interactions among twelve mutated genes. In terms of the functions and pathways of twelve gene mutations based on GO and KEGG, 40 tumor-related results are presented in this paper. Key regulated factor of Neuroendocrine carcinoma of gallbladder-related genes was established. In addition, the biological functions and features of gallbladder NEC are further compared with gallbladder carcinoma.
Conclusion: Gallbladder NEC urgently requires standardized and effective treatment protocols. Gallbladder NEC can be compared with other gallbladder carcinoma that have characteristic clinical phenotype, molecular alterations, functional information and enrichment pathway.
The entry sum of the inverse Cauchy matrix
Authors: Grinberg Darij
Published: January 2023

[This is submitted for the "Gems and Curiosities" column, which usually does not have abstracts.]
To determine if changing to white light street lamps improves road safety: A multilevel longitudinal analysis of road traffic collisions during the relighting of Leeds, a UK city
Authors: Marchant Paul , Norman Paul
Published: January 2023

Background
Large-scale installation of broad-spectrum (white) road lighting has been claimed to bring about a substantial reduction in road traffic collisions (RTCs). This confirmatory study estimates the effect on personal injury RTCs of a relighting programme that installed nearly 80,000 new white lamps, between the years 2005 and 2013, throughout the large UK city of Leeds.
Methods
Time series of weekly RTC personal injury counts in 107 areas, within the city over nearly 9 years when its road lighting was almost completely relit, were analysed, using multilevel modelling. The background change in each area when and where no lighting was being changed was separated from that associated with when and where new replacement white lamps were installed by including a polynomial for the underlying time-trend. The key interest is how the installation of the new lamps affects the ratio of the rate of collisions occurring in darkness to those occurring in daylight. The measure sought is given by the daylight adjusted darkness collision rate ratio (CRR) for the specified amount of relighting, that is the factor by which the daylight adjusted collision rate changes by the specified change in lighting.
Results
The daylight adjusted darkness collision rate ratio (CRR) has a point estimate of 0.990 and a 95% confidence interval, CI (0.971, 1.010) for 100 replaced lamps; representing a range between a 3% reduction in the collision rate to a 1% increase. Using the series truncated at the end of 2011 that seems more trustworthy, gives a revised point estimate of 0.993 and a CI (0.971, 1.015). Both CIs include one, therefore no effect on road safety was detected. The CIs for any other number of lamps installed will also include one. Typically, the plausible range of road safety impact brought by the new white lamps for a typical area with 700 lamps, roughly spans 20% reduction to a 10% increase for the daylight adjusted darkness collision rate.
Conclusion
No convincing evidence was found for an improvement (or detriment) in road safety by relighting with white lamps, despite the extensive, city-wide installation efforts and associated costs.
Monitoring and Evaluation of 2015 Devrek Zonguldak Landslide within the scope of Flood Risk Assessment by Landsat-8 Satellite Data
Authors: GÜVEL Şerife Pınar , AKGÜL Mehmet Ali , AKKOYUNLU Mehveş Feyza
Published: January 2023

The mass movement towards stream beds and their accumulation there may cause flood events as a result of landslide events. In this study, Devrek Landslide, which occurred in 2015, was investigated by using a remote sensing technique. The Çomaklar stream is located at the lower elevations of this landslide region. Çomaklar stream and surrounding settlements are at risk of flooding due to the probability of preventing the water flow in the stream because of the effects of the landslide. Devrek district is located in Zonguldak in the northern part of Turkey. LANDSAT-8 satellite images between the dates 27 January 2015 and 22 July 2015 were used to investigate the location and size of the Devrek district landslide. Satellite-derived remote sensing data have been widely used in recent years to monitor changes on the earth's surface and to provide information. In this study, the Spectral Angle Difference method was used to compare the images before and after the landslide event. A change detection analysis was conducted between pre-landslide and post-landslide images to investigate the area affected by the disaster. As a result, the landslide was determined as 1050 meters in length and 110 meters in width, and the landslide area was calculated as 10.87 ha.
The Academic Integrity Technological Arms Race and its Impact on Learning, Teaching, and Assessment
Authors: Eaton Sarah Elaine
Published: January 2023

This essay discusses the technological arms race that has developed in response to academic cheating. The author highlights three technological advances that impact academic integrity, from oldest to newest: a) text-matching software, b) online exam proctoring software, and c) artificial intelligence and Large Language Models (LLMs). This essay argues that there is no “silver bullet” to preventing or investigating academic misconduct and that our ethical obligations for learning, teaching, and assessment must include a human focus to promote student success.
Ezoteryzm jako problem socjologiczny. Socjologia ezoteryzmu – socjologia religii – socjologia duchowości: wspólne i różne pola badawcze, wzajemne relacje
Authors: Kasperek Andrzej
Published: January 2023

Choć problematyka ezoteryczna nie należy do zbyt często podejmowanych na gruncie socjologii, nie znaczy to wcale, że jest ona nieistotna dla samej teorii socjologicznej. W ezoteryzmie przecinają się bowiem kluczowe socjologiczne zagadnienia: nowoczesności, zmiany społecznej, odczarowania świata, sekularyzacji czy kontrkultury. W artykule zostanie przedstawiona próba umieszczenia problematyki ezoteryzmu w socjologii w ramach oddzielnej subdyscypliny oraz określone zostaną najważniejsze pola badawcze tej subdyscypliny socjologicznej. Zwrócona zostanie także uwaga na wzajemne relacje, wspólne pola badawcze, ale i odmienne przedmioty zainteresowania socjologii ezoteryzmu, socjologii religii oraz socjologii duchowości.
educación ambiental promovida por las políticas de educación ambiental de Brasil y Colombia
Authors: Toro Luisa Fernanda Mejia , Vaz Arnaldo
Published: January 2023

Este trabajo tiene como objetivo comprender la corriente de educación ambiental (Sauvé, 2005) que se moviliza en las políticas públicas de educación ambiental de Brasil y Colombia, así como las disputas que se dieron para su elaboración. Analizamos el discurso de los documentos institucionales, para el Brasil la Ley 9.975 de 1999, el decreto 4281 de 2002 y el Programa Nacional de EA (2003, 2005, 2014); y para Colombia los Lineamientos generales para una política de Educación Ambiental (1995), y la ley 1549 de 2012 que consolida la política de educación ambiental de 2002. Presentamos un histórico de la construcción de estos programas, y un análisis sobre el concepto de Educación Ambiental presente en su discurso. Se destaca una predominancia de las corrientes crítica en Brasil y Sistémica en Colombia, además de identificar otras perspectivas del área como estrategia política y de negociación con otros sectores políticos e ideológicos.
tendência política da matriz nacional de competências para diretores escolares e o nascimento de uma proposta sociopolítica
Authors: Aguiar Viviane Barbosa Perez , Ruiz Maria José Ferreira , Silva Waléria Pimenta Martins
Published: January 2023

Este artigo problematiza a aprovação do projeto de resolução da Matriz Nacional de Competências para Diretores Escolares pelo Conselho Nacional de Educação (CNE). Tem como objetivo geral demonstrar o projeto de formação de diretores escolares direcionado pela resolução em questão. Como objetivos específicos pretende: (i) demonstrar os elementos neoliberais presentes na Matriz Nacional e o seu compromisso com o modelo de gestão gerencial; (ii) discutir a orientação epistemológica que fundamenta o documento; (iii) apresentar uma proposta de matriz de conteúdo para a formação de diretores e coordenadores. O estudo pautou-se no desenvolvimento de pesquisa bibliográfica e análise documental, como instrumentos metodológicos. Conclui-se que o documento elaborado pelo MEC tem orientação política voltada ao neoliberalismo e, no campo do conhecimento, à Epistemologia da Prática, portanto, não atende as necessidades formativas para o exercício da função na gestão escolar. Finaliza-se com uma possível alternativa de matriz formativa centrada na formação sócio-histórica.
WITHDRAWN: The ceRNA Network of Long Non-Coding RNA PCAT1/miR-128- 3p/SEC61A1 in Colon Cancer Cell Proliferation and Invasion
Authors: Xu Xiaoqing , Zhou Ronghong
Published: January 2023

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Renoprotective Effect of Thymoquinone against Streptozotocin-Induced
Diabetic Nephropathy: Role of NOX2 and Nrf2 Signals
Authors: Hofni Amal , Ali Fares E.M. , Ibrahim Ahmed R. N. , Aboubaker Esam M.
Published: January 2023

Objective:

Diabetic nephropathy is an unavoidable complication of chronic uncontrolled
diabetes mellitus. The pathogenesis of diabetic nephropathy is multifactorial, and the
development of an effective therapy remains to be elucidated. The aim of the present study was
to assess the role of NOX2 and Nrf2 in the protective mechanism of thymoquinone (THQ)
against streptozotocin (STZ)-induced diabetic nephropathy.

Methods:

Rats were injected with STZ (55 mg/kg) to induce diabetes. The diabetic rats were
orally treated with THQ (10 mg/kg/day) for eight weeks.

Results:

STZ-treated rats exhibit an elevation of serum creatinine, serum urea, and creatinine
clearance. The renal abnormalities were associated with increased NADPH oxidase isoform,
NOX2 protein expression, and activity, along with elevated malondialdehyde (MDA). In addition,
the tumor necrotic factor-alpha (TNF-α) level and nitric oxide (NO) bioavailability, as well as the
transforming growth factor-beta (TGF)-β, were markedly increased. On the other hand, the nuclear
factor-E2-related factor (Nrf2) protein expression was significantly reduced in diabetic rats
compared to the control. However, treatment with THQ significantly reversed these alterations
with subsequent ameliorating renal dysfunction and pathological abnormalities.

Conclusion:

The present study demonstrates that THQ could protect against STZ-induced diabetic
nephropathy by modulating the Nrf2/NOX2 signaling pathway.
Development of an Interpolation Scheme for Seismic Indexes in Lima Metropolitan, Peru
Authors: Garay Avendaño Roger Leonardo , Moya Huallpa Luis Angel , Gonzales Trujillo Carlos Eduardo , Lazares La Rosa Luis Fernando , Diaz Figueroa Miguel Augusto , Zavala Toledo Carlos Alberto , Yamazaki Fumio , Calderon Cahuana Diana Lucia , Huerta Gonzales Kevin Steve
Published: January 2023

In recent years, the development of seismic networks in Metropolitan Lima, administrated by public and private institutions, has received special attention since it makes possible the quantification of different seismic indexes under the occurrence of earthquakes. Therefore, the integration of the information both from acceleration sensors and site conditions from microzoning studies allows the estimation of the possible extent of the damage in quasi-real time. In this study, the implementation of a system to evaluate seismic parameters in a uniform grid of 250 x 250 m2 resolution is reported. In this regard, peak ground acceleration (PGA) values from the available time-history records are computed and reduced to the engineering bedrock level. Then, by means of the interpolation technique called Ordinary Kriging, in which each seismic station is considered as a random variable and the correlation between a pair of such random variables depends only on the distance between their coordinates, the acceleration distribution is evaluated. Amplification factors are applied in order to finally bring the PGA up to the surface level. A quantitative evaluation of the accuracy of our results is performed using two recent earthquakes with moment magnitude larger than 5:  the 2019 Mw 8.0 Lagunas earthquake and 2021 Mw 6.0 Mala earthquake. The results have reproduced to some extent the seismic response of the diverse geomorphological deposits in Metropolitan Lima and suggest the inclusion of a larger number of strong motion stations in order to reduce the estimation errors.
Modeling and simulation of magnetorheological dampers for the reduction of the seismic response of structures using simulink
Authors: Guzmán Prado Miguel Raúl
Published: January 2023

The control devices can be used to dissipate the energy of structures subjected to dynamic loads in order to reduce structural damage and prevent the failure of them. The semiactive control devices that have received great attention in recent years are magnetorheological (MR) fluid dampers due to their mechanical simplicity, high dynamic range, large temperature operating range and low power requirements. In the present research work, Matlab and Simulink are used as computational tools for the modeling and simulation of structural control systems with magnetorheological dampers (MRDs). To begin with, the modeling is carried out through simulink block diagrams of the governing differential equations of representative mathematical models of MRDs. Next, a series of simulations is performed in order to replicate experimental results and to be able to validate the modeling step. Finally, the MRDs are integrated together with a semiactive control algorithm and an idealized ten-degrees-of-freedom structure. The main expected outcome is the reduction of the seismic response (response histories, drifts, shear forces and overturning moments).
Estudio experimental de las propiedades mecánicas del hormigón simple y reforzado con fibras bajo carga monotónica
Authors: Reyna Salazar Roy , Santos Acco Cristiam's Jesús , Acuña Asenjo Carlos Alberto
Published: January 2023

Concrete is one of the main building materials in Peru and worldwide, the study of its mechanical properties and concrete mix elaboration have been extensively developed over time. In the last years, new ways of elaboration with different materials have been searched, in order to improve its mechanical properties, including the fiber reinforced concrete. The study of its strain-stress mechanical properties of fiber reinforced concrete under monotonic load is the objective of this investigation, based on experimental tests performed in 90 samples, taking into account the influence of many factors, such as: Compression strength design, sample section geometry (square or circular section), slenderness (height/depth ratio), and the comparison of the reinforced concrete with its equivalent plain concrete in terms of mix design. From the experimental results, the use of fiber reinforcement increases the deformation capacity of the concrete under monotonic compression, but its resistance is not improved significantly. On the other hand, square section specimens have a higher deformation capacity for slenderness 1:2 and 1:3 in comparison with circular section specimens.
Structure and properties of composites based on aluminum and gallium nitrides grown on silicon of different orientations with a buffer layer of silicon carbide
Authors: Sharofidinov Sh. Sh.  , Kukushkin S. A.  , Staritsyn M. V.  , Solnyshkin A. V.  , Sergeeva O. N.  , Kaptelov E. Yu.  , Pronin I. P.
Published: January 2023

The microstructure and pyroelectric properties of AlxGa1-xN composite epitaxial layers grown on SiC/Si(111) and SiC/Si(110) hybrid substrates by the chloride-hydride epitaxy have been studied. The phenomenon of spontaneous formation of a system of heterojunctions consisting of periodic AlxGa1-xN layers of different composition located perpendicular to the direction of growth, was discovered during the growth of layers. Measurements of the pyroelectric coefficients of these heterostructures have shown that regardless of the orientation of the initial Si substrate and their pyroelectric coefficients have close values of the order of γ~(0.7-1)·10-10 C/cm2K. It is shown that to increase the magnitude of the pyroresponse it is necessary to deposit an AlN layer with a thickness exceeding 1 μm on the AlxGa1-xN/SiC/Si surface. This leads to record values of the pyroelectric coefficient γ~18·10-10 C/cm2K for AlN crystals and films. Keywords: silicon carbide-on-silicon substrates, chloride-hydride epitaxy, AlGaN epitaxial layers, aluminum nitride, gallium nitride, pyroelectric properties.
The effect of line-by-line laser scanning on the properties of laser-induced graphene
Authors: Mikheev K. G.  , Zonov R. G.  , Syugaev A. V.  , Bulatov D. L.  , Mikheev G. M.
Published: January 2023

Technology of polyimide (PI) film carbonization by direct laser treatment attracts much attention due to the versatility and ease of obtaining the carbon material, laser-induced graphene (LIG), used in the creation of various sensors and functional devices. In this work LIG film structures are obtained by line-by-line scanning of a cw CO2 laser beam over the surface of the PI film. The synthesized carbon film material is studied by optical and scanning electron microscopy, X-ray photoelectron spectroscopy and Raman spectroscopy. It is shown that the Raman spectra of a single LIG line and a set of overlapping LIG lines significantly differ from each other. It is found that multiple laser scanning of the PI film leads to a marked decrease in the number of defects in the LIG structure as well as to a significant decrease in the specific surface resistance of the synthesized film material. The results obtained can be used in the synthesis of LIG film structures with improved characteristics. Keywords: laser-induced graphene, polyimide film, line-by-line laser scanning.
Ab initio and Experimental Study of Vibrational Properties of In-=SUB=-2-=/SUB=-Se-=SUB=-3-=/SUB=-
Authors: Jahangirli Z.A.  , Gojayev E.M.  , Qaribli A.F.  , Bayramova T.O.
Published: January 2023

The results of investigation of the vibrational properties of the semiconductor compound In2Se3: by the density functional perturbation theory (DFPT) and experimentally using Raman spectroscopy are presented. Comparison of Raman scattering measurements and results of calculations of lattice dynamics allowed us to identify four Raman active modes found at 91.28, 104.5, 182.68 and 193.6 cm-1. The phonon modes were identified by considering the point group symmetry. The results of identification of phonon modes confirmed the R3m-symmetry of the α-In2Se3 phase. A comparison is also made with the results of the experimental data available in the literature obtained by the method of Raman spectroscopy. The calculated frequencies and symmetries of the phonon modes at the center of the Brillouin zone are in good agreement with the experimental data. Keywords: In2Se3, Raman scattering, IR- and Raman active modes, phonon dispersion, phonon density of states.
Control of the direction of propagation of spin waves in an ensemble of laterally and vertically connected ferrite microstrips
Authors: Khutieva A. B.  , Akimova B. R.  , Beginin E. N.  , Sadovnikov A. V.
Published: January 2023

The possibility of controlling the direction of propagation of spin waves in an ensemble of laterally and vertically connected microstrips of iron-yttrium garnet (YIG) is shown by numerical modeling. Using the finite element method, the magnitude of the coupling length of spin waves in lateral and vertical geometries was calculated. The numerical value of the spin wave coupling coefficients was found by the finite element method as a result of solving a system of Maxwell equations with a magnetic permeability tensor obtained from the linearization of the Landau-Lifshitz equation. By integrating the equation of coupled waves, the possibility of changing the direction of propagation of the spin-wave signal in the structure under consideration is shown. The signal transmission spectra obtained in micromagnetic modeling indicate a change in the nature of the localization of the spin wave power in the output sections of the microwave with a change in the frequency at the input of the structure. The system of laterally and vertically connected microwave diodes is an element of interconnections for three-dimensional topologies of magnon networks, while demonstrating the functionality of spatial-frequency signal demultiplexing. Keywords: spin waves, magnonics, lateral structures, magnonic crystal, ensembles of related structures. Keywords: spin waves, magnonics, lateral structures, magnonic crystal, ensembles of related structures.
Diffusion of Phosphorus and Gallium from a Deposited Layer of Gallium Phosphide into Silicon
Authors: Zikrillaev N. F.  ,  Koveshnikov S. V.  , Kh.S. Turekeev Kh. S.  , Norqulov N.  ,  Tachilin S. A.
Published: January 2023

Diffusion from a layer of gallium phosphide GaP deposited onto a silicon surface was studied. After diffusion, the silicon samples were examined by the Van der Pauw method, and a scanning electron microscope was used to determine the concentration distribution of phosphorus and gallium atoms impurity. Keywords: diffusion, gallium phosphide, silicon, solubility, concentration, binary complexes.
Formation of catalyst nanoparticles for the growth of carbon nanotubes during annealing of amorphous Co-Zr-O films
Authors: Bulyarskiy S.V.  , L'vov P. E.  , Pavlov A. A.  , Terentyev A.V.
Published: January 2023

The formation of nanosized catalyst particles for the growth of carbon nanotubes can be carried out during the crystallization of amorphous films consisting of two metals, one of which has higher free energy of the oxide. During annealing in the presence of oxygen, this metal is oxidized with the reduction of the second metal, which leads to the formation of nanoparticles embedded in the oxide of the first metal. This the process has been experimentally and theoretically studied by the example of the formation of cobalt nanoparticles on the surface of amorphous Co-Zr-O films as a result of the decomposition of a supersaturated solid solution and mechanical stresses arising during the oxidation of zirconium. We have proposed a mechanism for the formation of catalyst nanoparticles and phenomenological model of this process developed on the basis of the phase-field theory. Keywords: carbon nanotubes, nanoparticles of catalyst, phase transitions, decomposition of supersaturated solid solutions.
Influence of intragranular Meissner currents and magnetic flux trapped in granules on the effective field in the intergranular medium and the magnetoresistance hysteresis of a granular HTSC
Authors: Balaev D. A.  , Semenov S.V.  , Gokhfeld D. M.
Published: January 2023

The concept of an effective field in an intergranular medium is used to describe the hysteresis magnetoresistance of granular HTSCs. This effective field is a superposition of the external magnetic field and the field induced by the magnetic moments of the superconducting granules. The magnetic moment of the granules is contributed by the shielding currents and the trapped magnetic flux. We studied and analyzed the effect of the trapped flux on the magnetoresistance. It has been experimentally shown that the dependence of the residual resistance RRem (after applying of the external field) on the trapped flux clearly correlates with the behavior of the remanent magnetization. In addition, special attention was paid to a detailed comparison of the magnetoresistance of the granular YBa2Cu3O7-delta for two cases: (a) the magnetization of HTSC-granules is caused only by the trapped magnetic flux (in a zero external field) and (b) HTSC-granules are in the Meissner state (the external field is smaller than the first critical field of the granules). It has been found that Abrikosov vortices and intragranular Meissner currents differently affect the effective field in the intergranular medium (for the same values (of magnetization for cases (a) and (b) ). A possible reason for this difference is discussed. Keywords: granular HTSC, magnetoresistance hysteresis, magnetization hysteresis, trapped flux, screening currents.
Phonons and the Ioffe-Regel crossover in random lattices with arbitrary dimension
Authors: Conyuh D. A.
Published: January 2023

In the frame of the random matrix theory, it was shown, that the relaxation of the projection of the initial plane wave with the wave vector q is described by the equation of motion with the memory function which corresponds to the complex dynamical Young modulus E(ω). In the harmonic scalar model of displacements with the absence of energy dissipation, the Ioffe-Regel crossover arises universally in amorphous systems with the dimension d≥3. Vibrations above the Ioffe-Regel crossover are related to the diffusive nature and can be described by the diffusion equation with the damping ( q) propto q2. Keywords: Amorphous solids, diffusons, random matrices.