bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review of the Effects of Textual Enhancement on Second Language Learning
Authors: Guo Tiantian
Published: January 2023

Textual enhancement refers to techniques for making target linguistic features in a text more perceptually salient. Textual enhancement has been frequently studied as a promising instructional method for promoting language learning. This paper reviewed studies on the role of textual enhancement in terms of vocabulary and grammar learning, second language speaking, writing, reading, and pragmatic competence. In addition, this paper also pointed out the problems of current research and the direction of future research. To prove the effectiveness of second language learning, researchers should further explore the effects of textual enhancement in various language environments.
PENGARUH BAHAN TANAM DAN PEMBERIAN PACLOBUTRAZOL TERHADAP PERTUMBUHAN DAN PEMBUNGAAN TANAMAN HORTENSIA (Hydrangea macrophylla)
Authors: Nawahepta Dwinesa Aprinda , Kusumaningrum Nora Augustien , Sutini Sutini
Published: January 2023

Pemangkasan dengan meninggalkan 1-2 ruas dan penambahan ZPT paclobutrazol pada tanaman hortensia mampu menghasilkan bunga yang banyak atau lebih cepat dari sebelumnya. Tujuan dari penelitian ini adalah mengetahui kombinasi antara jumlah ruas bahan tanam dan konsentrasi paclobutrazol terhadap hasil pembungaan tanaman hortensia. Penelitian dilaksanakan di Taman Bunga Coban Talun, Dusun Wonorejo, Desa Tulungrejo, Kecamatan Bumiaji, Kota Batu, Provinsi Jawa Timur. Penelitian dilaksanakan pada bulan April sampai September 2020. Penelitian ini merupakan percobaan factorial yang disusun berdasarkan Rancangan Acak Lengkap (RAL), faktor pertama bahan tanam (1 pasang daun, 2 pasang daun) faktor kedua konsentrasi paclobutrazol (konsentrasi 0 ppm, 100 ppm, 200ppm, 300 ppm, 400ppm) dan 3 kali ulangan. Hasil terbaikdihasilkan pada perlakuanbahantanam 1 pasangdaun + konsentrasi paclobutrazol 0 ppm (B1P0) terhadap tinggi tanaman; perlakuan bahan tanam 2 pasang daun + konsentrasi paclobutrazol 200 ppm (B2P2) terhadap jumlah daun; perlakuan 2 pasang daun + konsentrasi paclobutrazol 400 ppm (B2P4) terhadap waktu bunga terbentuk.
KEANEKARAGAMAN SERANGGA HAMA PADA TANAMAN PADI DENGAN APLIKASI Streptomyces sp. DAN Trichoderma sp. DI DESA MOJOTENGAH KABUPATEN GRESIK
Authors: Wiranthi Alifta , Suryaminarsih Penta , Windriyanti Wiwin
Published: January 2023

Tanaman padi seringkali mendapat gangguan dari organisme pengganggu tumbuhan (OPT) yang mengakibatkan menurunnya kualitas serta kuantitas produksi padi. upaya meningkatkan produksi bahan, agar mendapatkan hasil produksi dengan kualitas dan kuatitas yang tinggi adalah dengan pengendalian hama terpadu (PHT). Permasalahan hama dan penyakit tanaman merupakan bagian yang tidak dapat lepas dalam budidaya tanaman. Pemanfaatan agensi hayati sangat efektif dari segi biaya dan mengurangi efek negatif yan ditimbulkan oleh penggunaan pestisida kimia. Mikroorganisme merupakan agensi hayati yang mampu mengendalikan serangga hama. Genus Steptomyces sp. dan Trichoderma sp. menghaslkan enzim kitinase. Penelitian ini bertujuan mengetahui pengaruh aplikasi agensi hayati Streptomyces sp. dan Trichoderma sp. terhadap jenis, komposisi, dan populasi serangga, indeks keanekaragaman hama pada lahan tanaman padi  di Desa Mojotengah Kabupaten Gresik. Penelitian ini menggunakan metode survei menggunakan cara pengamatan langsung, penangkapan serangga dilakukan menggunakan jaring (sweep net), perangkap likat kuning (yellow sticky trap), dan perangkap sumuran (pitfall trap). hasil penelitian dilahan pertanaman padi dengan populasi serangga yang ditemukan pada lahan dengan aplikasi agensi hayati sejumlah 280 individu dan tanpa agensi hayati 775 individu. Aplikasi agensi hayati Streptomyces sp. dan Trichoderma sp. berpengaruh terhadap jumlah  populasi hama. Aplikasi agensi hayati Streptomyces sp. dan Trichoderma sp. berpengaruh terhadap nilai indeks keanekaragaman jenis termasuk kategori sedang, indeks kemerataan pada kedua lahan termasuk kategori sedang, indeks kekayaan jenis menunjukkan tingkat kekayaan jenis tinggi pada kedua lahan, indeks dominasi  menunjukan nilai termasuk kategori sedang.
Development of Empirical Models to Predict Gap Acceptance Parameter Based on the Geometrical and Operational Parameters of Different Roundabouts
Authors: Al Hasanat Haitham A. , Juhász János
Published: January 2023

This paper develops a mathematical formula that accounts the influence of roundabout’s design and performance parameters to predict the gap acceptance parameter “Critical gap”. Thirteen roundabouts in Hungary having different geometric and operational parameters were selected. The geometrical and operational data of each roundabout’s leg was collected. Raff's method was used to estimate the critical gap for each roundabout leg. Firstly, the collinearity analysis was carried out to identify independent parameters to avoid any possible negative impact on the developed predictive models. Nine out of ten parameters passed the collinearity test. These nine parameters are the main parameters used in the model development. Three models were developed. The first model (M1) is based on Multivariate Adaptive Regression Spline (MARS) algorithm. The second model (M2) is based on Pearson correlation. The last model (M3) was based on Spearman correlation. Linear regression models were constructed using the retained parameters of the M2 and M3 models. Subsequently a comparison of the three developed models is done based on R2 and RMSE values. Based on the results obtained from the comparison, the MARS model (M1) is the best predictive model of the critical gap. According to the results of the MARS model, the most important parameters for predicting critical gap value are circulating traffic flow and the distance between neighboring legs.
Societal disorder as a precursor to dangerous minds in politics
Authors: Lee Bandy X.
Published: January 2023

Violence as a public health emergency, and the rise in recent years of dangerous, mentally impaired leaders across the globe demonstrates vividly the importance of education and prevention with respect to the public health and mental health factors that play a role in contemporary international politics. “Strongmen”—or, more accurately, fragile men—including Donald Trump, Vladimir Putin, Jair Bolsonaro, Rodrigo Duterte, Mohammed bin Salman, Kim Jong-un, and Xi Jinping, amongst others, all portray themselves in a defensive and overcompensating show of force that threatens not just their own people and neighbouring countries, but the survival of humankind. This article will outline the importance of considering these leaders in public health terms, as manifestations of a societal and cultural disorder after decades of toleration of structural violence and violent policies. As personality disorder writ large, cultural disorder not only gives rise to but supports the rise of dangerous personalities in leadership positions.
Nontradional Detection of Soil Moisture Content Based On Hyperspectral Imaging Technique
Authors: Wu Longguo , Jiang Qiufei , Zhang Yao , Wang Songlei
Published: January 2023

In the study, Vis-NIR hyperspectral imaging technique was investigated for non-destructive determination of soil moisture content. A total of 208 spectral information of soil samples by hyperspectral imaging system were collected. The differences between soil's moisture content and spectral changes were compared. Different methods of spectral data preprocessing methods, characteristic wavelengths extraction, and building models had influences on the performance of model established. Results from this investigation demonstrated that the reflectivity of soil spectrum were declining with the increase of soil moisture content. Once soil moisture content reached the limit of the field water holding capacity, the reflectivity of soil spectrum were increasing with the increase of soil moisture content. The methods of different pretreatment were analyzed, and the pretreatment method of normalization of unit vector was proposed. The number of characteristic wavelengths extracted by the method of uninformative variable eliminate (UVE), competitive adaptive reweighted sampling (CARS), beta coefficient (β), successive projections algorithm (SPA) were 49, 30, 5, 7, respectively. In order to reduce data redundancy, characteristic wavelengths extracted by the method of UVE and CARS were further extracted by SPA method. The number of characteristic wavelengths extracted by the method of UVE + SPA and CARS + SPA were 5, 8, respectively. The MLR model built based on the characteristic wavelengths extracted by the β coefficient was chosen as the best model, which of the optimal characteristic wavelengths were 411, 440, 622, 713, 790 nm, respectively. The correlation coefficient (Rp) and the root mean square error (RMSEP) for prediction set were 0.979 and 0.763, respectively. Therefore, it is feasible to predict soil moisture content using hyperspectral imaging technique.
Bangladesh J. Bot. 51(4): 1039-1049, 2022 (December) Special
Girón Atlas Cantonal
Authors:   Universidad del Azuay, Ochoa-Arias Paúl
Published: January 2023

Algunos de los atributos representativos del cantón son las tres cascadas del Chorro, la primera de ellas tiene una altura de 70m y forma una poza de agua cristalina y fresca, muy aprovechada por los turistas. A lo largo del recorrido que se realiza caminando, se puede divisar una especial y variada flora, fauna y paisajes naturales. El cantón está constituido por tres parroquias: Girón, San Gerardo y Asunción. La primera de ellas ocupa aproximadamente el 70 % de la superficie total, y las otras dos el 16% y 14 % respectivamente. Recorren sus territorios los ríos Girón, Santa Ana, Rircay y San Gregorio. 126 páginas e-ISBN 978-9942-847-15-7
ENGLISH VOCABULARY AND GRAMMAR PROFICIENCIES OF SMPN 17 STUDENTS IN BENGKULU CITY
Authors: Muhamad Reza , Zahrida  , Mukhrizal
Published: January 2023

The objectives of this research were to find out “how the student’s English vocabulary and grammar proficiencies were” . The population was all students of SMP N 17 Bengkulu City. The samples were approximately 57 students, with detail were 4 classes of 7th grade. The design of the research was descriptive quantitative. The instrument was English grammar and vocabulary test to measure students’ skill. The results of the research showed that the total average score from grade 7th, their total average score was 33, their average vocabulary score was 20 and then their average grammar score was 44. Based on the results, it can be concluded that the 7th grade students’ vocabulary and grammar skills of SMPN 17 Bengkulu City were still low, also the difference between their average grammar and vocabularyscores of grade 7 was very far, but both’s scores were still under the minimum score (75). This phenomenon could have been prevented if junior high school students had received English background knowledge when they were still in elementary school.This phenomenon is what the researchers are trying to show that this is the effect of not getting background knowledge of English when they were in elementary school. Of course this will cause problems for these students in the future, because the level of difficulty in terms of English study they will encounter in the future will be more difficult.
Computed tomography in the diagnosis of COVID-19 associated pneumonia in Med-Art medical center
Authors:   Med-Art Medical Center, Khabarovsk, Russia, Puchnin V.V. , Puchnin A.V. ,   Med-Art Medical Center, Khabarovsk, Russia, Savkova V.M. ,   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai
Published: January 2023

Given the gained experience, the algorithm of spiral computed tomography in the diagnosis of focal changes in the lungs caused by the new coronavirus infection Covid-19 (SARS-CоV-2) is described in the article
Providing medical care to patients with acute ocular pathology in pandemic
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russia, Udovichenko E.V. , Kolenko O.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russia, Pshenichnov1 M.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russia, Danilova L.P. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, Khabarovsk, Russia, Sorokin E.L.
Published: January 2023

Purpose. Comparative assessment of frequency and structure of patients who underwent inpatient treatment for acute eye pathology before and during the coronavirus infection (COVID-19) pandemic. Material and methods. A quantitative analysis was carried out in 826 patients treated for various acute eye pathologies in the Khabarovsk branch of the S. Fyodorov Eye Microsurgery Federal State Institution (the Branch) for the time periods: from May 2018 to February 2020 (the first) and from March 2020 to the end of December 2021 (the second). An assessment of frequency and nosological forms of diseases was carried out, examples of most severe cases of diseases and injuries were given.Results. For the first period, 318 patients were treated, for the second period - 508 patients. In the second period, there was significant increase in number of patients with acute eye pathology by 1.6 times. In both periods, patients with inflammatory lesions of tuveal tract prevailed: before the pandemic - 179 eyes, during the pandemic - 243 eyes. Also in the second period, 29 cases of severe burns of the cornea - II and III degrees were registered. Conclusion. All patients who applied to the Branch during study periods and needed emergency ophthalmic care were provided in timely manner and in full. The COVID-19 pandemic has made significant adjustments to work of the entire Branch, including work of Complex Rehabilitation Treatment Department in form of increase in number of patients with acute eye pathology by 1.6 times.
MEDICAL CADRES DECIDE EVERYTHING
Authors:   Government of the Khabarovsk Krai, Khabarovsk, Russia, Nikonov E.L. , Boychenko Yu.Ya. ,   Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia, Chumakova O.A. ,   Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia, Korablev V.N.
Published: January 2023

he article is devoted to assessing the situation to ensure healthcare of the Khabarovsk Krai with medical personnel. The authors analyzed the dynamics of the number of doctors and nurses of medical organizations subordinate to the Ministry of Health of the Khabarovsk Krai, from 2010 to 2021, as well as the staffing of healthcare institutions, the age breakdown of the personnel, and employment. Separately covered the problems of the provision of the out-patient clinics by district doctors, the implementation of the Zemsky doctor / Zemsky Feldsher program, the admission of students at the Far Eastern Medical University for employer-sponsored education, and the provision of housing for medical workers. The final part of the article is devoted to the main areas of solving the problem of eliminating the shortage of medical personnel
The case of the successful application of the method of bone-skin reconstruction reposition-flap in the complete removal of the distal phalanx of the finger
Authors:   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Berezutsky S.N. , Volovik V.E. ,   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Rykov A. G. ,   RZhD-Meditsina, Clinical Hospital of Russian Railways, Khabarovsk, Russia, Chechurin A.S. ,   O. V. Vladimirtsev Regional Clinical Hospital of the Ministry of Health of the Khabarovsk Krai, Khabarovsk, Russia
Published: January 2023

This clinical case presents a successful bone reconstruction of the distal finger after its complete removal using the reposition- flap method in modification in the 23 years old patient. The methodology of the operation is described, the closest postoperative outcome, the features of the managment of this category of patients are shown
Critically endangered franciscana dolphins in an estuarine area: fine-scale habitat use and distribution from acoustic monitoring in Babitonga Bay, southern Brazil
Authors: Paitach RL , Bortolotto GA , Amundin M , Cremer MJ
Published: January 2023

Franciscana dolphins in Babitonga Bay represent the only fully estuarine population of this critically endangered species, but this location is also home to a population of Guiana dolphins. Surrounded by large cities and harbors, Babitonga Bay presents intense human activities and potential impacts that may threaten the dolphins. Understanding their habitat use and distribution can inform the implementation of conservation actions and mitigation of such impacts. Here, we used acoustic data from 60 fixed passive acoustic monitoring stations, implemented between June and December 2018. The relationship between the occurrence of franciscanas and environmental variables was investigated with generalized additive mixed models. The selected model presented 51% of explained deviance and included time of day, intensity of presence of Guiana dolphins, maximum slope, and bottom sediment, among other less statistically significant variables. A daily distribution pattern was identified, with franciscanas remaining in the areas of greatest occurrence especially in the morning and seeming to prefer sandy bottom and flatter areas. Areas intensively used by Guiana dolphins were avoided. Additionally, we mapped their distribution using empirical Bayesian kriging to identify the main areas of occurrence and for foraging. Franciscanas are consistently predominant in the innermost region of the estuary, without expressive use of the entrance channel, but with a wider range in winter than in spring. The area around the islands, between the north and south banks, represents an important foraging area, a behavior more frequent during dawn and night. This study provides important insights into critical habitats and behavioral patterns of critically endangered franciscanas in Babitonga Bay.
Demystifying the Discussion of Sequencing Panel Size in Oncology Genetic Testing
Authors: Durães Cecília , Pereira Gomes Carla , Costa Jose Luis , Quagliata Luca
Published: January 2023

Clinical laboratories worldwide are implementing next-generation sequencing (NGS) to identify cancer genomic variants and ultimately improve patient outcomes. The ability to massively sequence the entire genome or exome of tumour cells has been critical to elucidating many complex biological questions. However, the depth of information obtained by these methods is strenuous to process in the clinical setting, making them currently unfeasible for broader adoption. Instead, targeted sequencing, usually on a selection of clinically relevant genes, represents the predominant approach that best balances accurate identification of genomic variants with high sensitivity and a good cost-effectiveness ratio. The information obtained from targeted sequencing can support diagnostic classification, guide therapeutic decisions, and provide prognostic insights. The use of targeted gene panels expedites sample processing, including data analysis, results interpretation, and medical reports generation, directly affecting patient management. The key decision factors for selecting sequencing methods and panel size in routine testing should include diagnostic yield and clinical utility, sample availability, and processing turnaround time.

Profiling by default all patients with late-stage cancer with large panels is not affordable for most healthcare systems and does not provide substantial clinical benefit at present. Balancing between understanding cancer biology, including patients in clinical trials, maximising testing, and ensuring a sustainable financial burden for society requires thorough consideration. This review provides an overview of the advantages and drawbacks of different sizes NGS panels for tumour molecular profiling and their clinical applicability.
Pyoderma Gangrenosum: A Mini-Review
Authors: Rosmaninho Aristóteles , Carvalho Sandrina , Teixeira Vera
Published: January 2023

Pyoderma gangrenosum (PG) is a rare, chronic neutrophilic dermatosis of unknown aetiology that usually presents with necrotising ulcers, although the evolution of the disease can be variable and is not always progressive. Its pathogenesis is poorly understood but an underlying immunological abnormality seems to be implicated in the genesis of the lesions. This hypothesis is supported by its frequent association with inflammatory bowel disease, malignancies, and rheumatological disorders. The diagnosis is challenging even for dermatologists as there are no specific tests or histological features. There are no clinical trials evaluating the efficacy of the different drugs used to treat the disease due to its rarity, and therefore there is no ’gold standard’ therapy. In this mini-review we describe the main clinical aspects of PG, its pathophysiology, association with underlying diseases, diagnosis, treatment options, and prognosis.
KOMUNIKASI KEBIJAKAN PUBLIK DALAM PENGGUNAAN APLIKASI SISTEM PENGELOLAAN PENGADUAN PELAYANAN PUBLIK NASIONAL LAYANAN ASPIRASI DAN PENGADUAN ONLINE RAKYAT (SP4N LAPOR) DI KECAMATAN PANONGAN KABUPATEN TANGERANG
Authors: Ranama Aniza Lestari , Mulyanto Agus Iwan , Kurniawan Irvan Arif
Published: January 2023

Komunikasi kebijakan publik dilatarbelakangi dengan permasalahan kurangnya sosialisasi dari pihak Kecamatan Panongan untuk memberikan edukasi terkait penggunaan aplikasi SP4N LAPOR yang mengakibatkan masyarakat belum terbuka dan terbentuk wawasan serta keterampilannya mengenai aplikasi tersebut, tujuannya agar masyarakat lebih memahami adanya satu saluran penyampaian pengaduan masyarakat terkait pelayanan publik. Metode dalam penelitian ini menggunakan kualitatif deskriptif. Dari hasil penelitian yang didapat adalah perubahan sikap dan bertambahnya pengetahuan masyarakat mengenai aplikasi SP4N LAPOR sehingga sangat membantu masyarakat dalam berkomunikasi dengan Pemerintah. Namun untuk perubahan sikap secara menyeluruh, Kecamatan Panongan perlu waktu untuk menyelesaikan masalah karena hal tersebut berkaitan dengan pilihan seseorang dan tidak dapat dipaksakan.
Kata Kunci: Komunikasi, Kebijakan Publik, SP4N LAPOR
Kan Kültürü Örneklerinden İzole Edilen Gram Negatif Bakterilerin Antibiyotik Direnç Profillerinin İncelenmesi
Authors: KALAYCI ÇEKİN Zuhal , BEHÇET Mustafa , AVCIOĞLU Fatma , AFŞAR Yusuf , ŞENTÜRK Ersin , KURTOĞLU Muhammet
Published: January 2023

Amaç: Son yıllarda geniş spektrumlu antibiyotiklerin yaygın kullanımı nedeniyle çoklu ilaca dirençli bakterilerde meydana gelen artışlar dünya çapında acil bir sorun haline gelmiştir. Bu çalışmada kan kültürü örneklerinden izole edilen Gram negatif bakterilerin antimikrobiyal direnç paternlerinin saptanarak ampirik tedavi ve antibiyotik kullanım politikalarına katkıda bulunulması amaçlanmıştır. Gereç ve Yöntemler: Laboratuvarımıza Haziran 2018-Haziran 2021 tarihleri arasında gönderilen kan kültüründen izole edilen 495 Gram negatif bakteri izolatı retrospektif olarak incelenmiştir. Bakterilerin identifikasyonu için konvansiyonel yöntemler ve tam otomatize cihaz (VITEK2, bioMerieux, Fransa) kullanılmıştır. Tiplendirme sonrasında izolatların antibiyotik duyarlılık testleri, VITEK2 sistemi ile yapılmış, EUCAST (European Committee on Antimicrobial Susceptibility Testing) kriterlerine göre yorumlanmıştır. Bulgular: Gram negatif izolatlar, sıklıkla yoğun bakım servislerinden izole edilmiştir (%39). Gram negatif bakteriyemilerde saptanan etkenler sıklık sırasına göre; Escherichia coli %33,9, Klebsiella pneumoniae %19,1, Acinetobacter spp. %18,5, Pseudomonas spp. %10,3 ve Enterobacter spp. %4,6 bulunmuştur. E.coli’ de daha az direnç karbapenemlere (meropenem %0, imipenem %2,9 ve ertapenem %3,7) , tigesikline %1,8, ve amikasine karşı %2 saptanmıştır. Enterobacterales izolatlarında daha az direnç oranları sırasıyla karbapenemlere (%6,8-14,5) amikasine (%10,6) ve tigesikline (%15,9) karşı bulunmuştur. Pseudomonas spp.’de daha az direnç amikasine (%11,8) ve karbapenemlere (%13,7-22,7) karşı saptanmıştır. Sonuç: Karbapenemler, amikasin ve tigesiklin dışındaki bazı antibiyotiklere direnç oranlarının yüksek oranda saptanması, hastalara ampirik antibiyotik tedavinin dikkatli şekilde uygulanması gerektiğini göstermektedir. Bu sonuçların hastanemizde akılcı antibiyotik kullanımına ve ampirik tedavi seçimine katkı sağlayacağı kanaatindeyiz.
Helicobacter pylori Eradikasyonunda Kullanılan Kombine Tedavilerin Etkinliklerinin Karşılaştırılması
Authors: ÇAĞLAR Recep
Published: January 2023

Amaç: Helicobacter pylori; ülser, gastrik atrofi, intestinal metaplazi ve gastrik adenokanserlere neden olabilmektedir. Bu çalışmada H. pylori eradikasyonunda kullanılan kombine tedaviler ve bu tedavilere bizmut subsitrat (BS) eklenerek H. pylori eradikasyon oranlarının karşılaştırılması amaçlanmıştır.
Gereç ve Yöntemler: Ocak 2019- Ocak 2022 tarihleri arasında Mersin Şehir Eğitim Araştırma Hastanesi Gastroenterolojik Cerrahi Kliniğinde endoskopik biyopside H. pylori tespit edilen ve eradikasyonda 14 günlük; 1- Klasik üçlü tedavi, 2- Klasik üçlü tedavi + BS, 3- proton pompa inhibitörleri (PPI) + amoksisilin-klavulanik asit + metranidazol ve 4- PPI + amoksisilin-klavulanik asit + metranidazol + BS kombine tedavileri kullanan 190 hasta retrospektif olarak dört gruba ayrılarak çalışmaya dahil edildi.
Bulgular: Çalışmaya alınan 190 hastanın 85’i (%44,70) erkek, 105’i (%55,30) kadın ve yaş ortalaması 41,90 idi. H. pylori eradikasyonu için klasik üçlü tedavi kullanan 42 (%22,10) hastanın 27’si (%64,28), klasik üçlü tedavi + BS kullanan 44 (%23,20) hastanın 33’ü (%75), PPI + amoksisilin-klavulanik asit + metranidazol kullanan 43 (%22,60) hastanın 35’i (%81,39) ve PPI + amoksisilin-klavulanik asit + metranidazol + BS tedavi kullanan 61 (%32,10) hastanın 54’ünde (%88,52) H. pylori eradikasyonunun başarılı olduğu görülmüştür (p=0,027). Her dört grupta da H. pylori eradikasyon başarısı istatistiksel olarak anlamlı bulunmuştur (p<0,05).
Sonuç: H. pylori eradikasyonunda kombine tedavilere BS eklenmesi tedavi başarı oranlarını arttırmıştır. H. pylori eradikasyonunun başarılı şekilde yapılabilmesi, seçilen tedavi rejimi, hastanın uyumu ve antibiyotik direncine bağlıdır.
A Study on the Needs of Teaching and Learning Neologism: Focusing on Foreign Students and Preparatory Korean Language Teachers
Authors:   The Korean Society of Culture and Convergence, Lee Yeonjeong , Lee Jumi
Published: January 2023

In this paper, the perception of neologism was investigated and analyzed for foreign undergraduates and foreign preliminary Korean teachers. The list of newly coined words prepared in previous studies was presented to foreign undergraduates to analyze vocabulary awareness and perception of neologism, and the recognition and educational needs of neologism were analyzed and listed in the same way for foreign Korean teachers. Both foreign undergraduates and foreign prospective Korean teachers had low awareness of neologism, but the demand for teaching and learning was high. Although there is a limitation in that the survey was conducted on limited subjects, it is meaningful that vocabulary recognition and vocabulary education needs were analyzed and listed as priorities. In the future, it is necessary to structure the vocabulary list of neologism for education by organizing the high-frequency vocabulary list used by undergraduate students in college.
A Study on the Analysis and Support of Foreign Students' College Life in Korea : Focusing on the Case of B University
Authors:   The Korean Society of Culture and Convergence, Lee Hoohee
Published: January 2023

This study explored various experiences and difficulties in adapting to university life by foreign students through in-depth interviews related to university life in Korea. The study subjects were 9 international students enrolled in University B, which were sampled using the target sampling method, and in-depth interviews were conducted. Data were collected and analyzed based on Giorgi's phenomenological method. The research results were derived into a total of four components: academic adaptation, emotional adaptation, cultural adaptation, and social adaptation. In addition, the sub-components according to each component were finally organized into 10 categories. Based on these research results, the measures to be supported for foreign students to adapt to Korean university life were discussed in detail, and suggestions were made for follow-up research.
Augustine in the Journey of Remember the Truth
Authors:   The Korean Society of Culture and Convergence, Kim Youngchul
Published: January 2023

The purpose of this study is to discuss the meaning of true confession in the life of Augustine, who devoted his life to the search for truth. In addition, it is to look at the process of passion and confession that he dedicated to reminding of the truth. The contents of this study were as follows. First, Augustine's quest for truth was rational. His life of searching for the truth was full of mental wanderings and contradictions, but he overcame them with philosophical reason. Second, his journey to search for the truth was religious. And on that journey, there were philosophy and Christian teachings. Third, he was able to recognize the truth through conversion through harmony between reason and faith.
A Study on Rha Hye-seok’s Modern View of ‘Nature’
Authors:   The Korean Society of Culture and Convergence, Kim Yunkyung
Published: January 2023

This article examines the self-construction logic of the first-generation new women who planned themselves as modern subjects who confront the world through changes in the meaning of the word 'nature' translated in Na Hye-seok's early writings. If Lee Kwang-soo or Choi Nam-seon's 'nature' clearly exists as an object of conquest and overcoming at the opposite point of modern man, Rha Hye-seok's 'nature' exists as a vivid reality in the body of modern man and still dominates it. human destiny. It is a painful awakening to a powerful and incomprehensible object. If the former is a masculine modern experience represented by 'boy' or 'youth', the latter is a feminine modern experience represented by 'wife' or 'mother'.
A Study of Expanding Museum Visits for the Visually Impairments: A Proposal for Exhibition Using Lee Eungno’s
Authors:   The Korean Society of Culture and Convergence, Choi Seongmi
Published: January 2023

The purpose of this study is to suggest concrete ways to increase museum accessibility for the visual impairment, the most vulnerable group, so that the museum can be accessible to people with or without disabilities. The visual impairment is also a representative of cultural alienated in museums where most of exhibitions are visually oriented. Investigate the demands of visually impairment who want to visit museums and analyze new exhibition aids for the visual impairment set up by national museums. The exhibition method that is equally set up for the visual impairment from the standpoint of general visitors is discussed and proposed the policy. In addition, including the necessity and possibility of preparing an exhibition considering the visual impairment, the exhibition using Lee Eungno's  is examined. This study meaningful in suggesting the possibility of an exhibition that considering the visual impairment as a part of an lower the physical and psychological barriers of the museum.
The Structural Relationship Among Social Support, Grit, and Academic Self-efficacy in Nursing Students
Authors:   The Korean Society of Culture and Convergence, Lee Sangmi
Published: January 2023

This study was performed to investigate the structural relationship among social support, grit, and academic self-efficacy in nursing students. A descriptive survey study was performed from October 1 to 14, 2022. Self-reported data using structured questionaries were collected from 122 nursing students in an University. Collected data were analyzed by structural equation model using SmartPLS 3.3.7. Among social support systems in nursing students, parental and professional supports had significant positive impacts on the grit. The grit had significant positive impacts on academic self-efficacy. Also, the grit mediates significantly the relationship between parental support and academic self-efficacy. The grit is significant predictor of academic self-efficacy in nursing students. To enhance academic self-efficacy of nursing students, it is necessary to be developed the grit improvement programs considering to social support system.
Differences in Leisure Time by Age and Period of the Older Adults in Gyeonggi Province
Authors:   The Korean Society of Culture and Convergence, Kim Chunnam , Yoo Jaeeon
Published: January 2023

The purpose of this study is to provide academic and practical directions for leisure life in later life by empirically analyzing the differences in leisure time by age and period of the older adults in Gyeonggi province. Using the life time survey data of the National Statistical Office in 1999, 2004, 2009, 2014, and 2019, we examined the changes in leisure time and differences by characteristics of the older adults over 65 in Gyeonggi province. The Tobit analysis model to examine the difference in leisure time by age group and period was divided into weekdays and weekends, respectively. The dependent variables, leisure activities, were also subdivided into total, socialization and participation, culture and tourism, media use, sports, and others. The analysis results show that the weekend leisure time of older elderly over 75 years old is long, and the weekday leisure time of young elderly under the aged of 75 is relatively short. In recent years compared to the past, socialization and participating, and other leisure time have decreased, while media use and leisure time for sports have increased. These analysis results report the fact that the difference in leisure time between weekdays and weekends is complicated by age group and period of the older adults. Therefore, these results suggest that future studies should monitor the diversified leisure time of the older adults, and that social supports need to respond appropriately to their rapidly changing leisure needs and activities.
Protective forest plantations in potential conflict zones of transport and ecological networks
Authors: Lavrov V. , Zhytovoz А. , Sahdjejeva T.
Published: January 2023

According to the ideology of restoring the integrity plant cover areas, all transportation routes, other engineering structures and landscapes altered by man should be seen as barriers to the migration of wild animals and living matter in general. In sparsely wooded and agricultural areas such as south of Kiev region, almost only corridors for connection fragments of natural ecosystems, separated biotopes, remnants of natural areas frame are complexes of protective fo rest stands. We consider the degree of violation of the state, structure and development of protective forest stands of different functional purpose as part of the eco-network around the city of Bila Tserkva and arboretum «Oleksandria». The features of their anthropogenic damage, depending on the forest type, their position in the landscape concerning the different systems of transport communications and settlements have been determined. A considerable part of the tract «Tovsta» disappeared in the ХІХ–ХХ centuries as a result of development the city of Bila Tserkva, other settlements and the expansion of agricultural land. Nowadays tracts «Tovsta» and «Tomylivska cottage» stands close to settlements and transport routes that are attractive and accessible to people suffer the most. They dissected by railway connecting the city Kyiv with southern regions, Kyiv-Odessa highway and several other roads which are sources of negative impact on forest ecosystems. It was revealed in stands: unauthorized construction; extensive network of roads and trails; violation, trampling and sometimes destruction of the living over-soil cover, weeding it; contamination of territory with domestic and construction waste; mechanical damage, weakening trees and drying; major and accompanying species displaces alien Acer negundo L. Weakened stands — 29% (mostly oak), greatly weakened (pine, silver maple, elm, alder, oak, etc.) — 53, such that dry up (birch, elm) — 18%.
Molecular dynamics simulation of an entire cell
Authors: Stevens Jan A. , Grünewald Fabian , van Tilburg P. A. Marco , König Melanie , Gilbert Benjamin R. , Brier Troy A. , Thornburg Zane R. , Luthey-Schulten Zaida , Marrink Siewert J.
Published: January 2023

The ultimate microscope, directed at a cell, would reveal the dynamics of all the cell’s components with atomic resolution. In contrast to their real-world counterparts, computational microscopes are currently on the brink of meeting this challenge. In this perspective, we show how an integrative approach can be employed to model an entire cell, the minimal cell, JCVI-syn3A, at full complexity. This step opens the way to interrogate the cell’s spatio-temporal evolution with molecular dynamics simulations, an approach that can be extended to other cell types in the near future.
Case Report: Septic arthritis in children caused by Streptococcus pyogenes–rational use of antibiotics
Authors: Yu Dingle , Gao Waiwai , Guo Danchun , Lu Qinghua , Chen Yunsheng , Zheng Yuejie , Wang Wenjian , Yang Yonghong
Published: January 2023

To investigate the clinical characteristics and treatment of septic arthritis caused by Streptococcus pyogenes(S. pyogenes) in children, we retrospectively analyzed the clinical data, laboratory results, treatments and outcomes of three pediatric cases of septic arthritis caused by S. pyogenes occurring from 2016–2018. The three cases of septic arthritis included 1 boy and 2 girls, aged from 2–7 years. Two patients experienced fever, and in all three cases, the affected joints showed redness, swelling, an increased local skin temperature, tenderness and restricted limb movement. At the first visit, all three cases showed a significantly increased white blood cell count [(27.68–32.02)×109/mL] and a significantly increased erythrocyte sedimentation rate (113–134 mm/h). The C-reactive protein level was significantly increased in two cases (67 mg/L, 147.7 mg/L) and normal in one case. The procalcitonin level was normal in 1 case, elevated in 1 case, and undetected in 1 case. S. pyogenes isolated from cases 1 and 2 were emm1/ST28 and from case 3 was emm12/ST36. All patients were treated by abscess incision and drainage, and S. pyogenes was cultured in the abscess puncture fluid. All patients were treated with intravenous antibiotics after admission, and all patients were cured and discharged. The patients were followed up for 2 months, and their condition was improved and stable. No sequelae such as heart and kidney damage were detected. In conclusion, for children with septic arthritis, early diagnosis and timely treatment with incision and drainage followed by culture of the abscess puncture fluid are important. Once S. pyogenes infection is confirmed, β-lactam antibiotics provide effective treatment, avoiding use of broad-spectrum antibiotics.
Hybrids of Ixodes ricinus and Ixodes persulcatus ticks effectively acquire and transmit tick-borne encephalitis virus
Authors: Belova Oxana A. , Polienko Alexandra E. , Averianova Anastasia D. , Karganova Galina G.
Published: January 2023

Ixodes rici nus and Ixodes persulcatus ticks are the main vectors of tick-borne encephalitis virus (TBEV), which has three main subtypes connected with certain tick species: the European subtype, associated with I. ricinus, and the Siberian and Far-Eastern subtypes, associated with I. persulcatus. Distribution ranges of these species overlap and form large sympatric areas in the East European Plain and Baltic countries. It has previously been shown that crossing of I. ricinus and I. persulcatus is possible, with the appearance of sterile hybrids. Hybridization of ticks can affect not only the spread of ticks but also the properties of natural foci of arbovirus infections, in particular TBEV. In the present study, we analyzed the effectiveness of virus transmission from infected mice to larvae and nymphs and trans-stadial transmission (from larvae to nymph and adult) in I. ricinus, I. persulcatus, and hybrids. For this purpose, we bred a hybrid generation from the crossing of I. persulcatus females and I. ricinus males, and we used the Siberian and European subtypes of TBEV. We showed that after feeding on infected mice, virus prevalence in engorged ticks decreased over time, and after molting, the opposite was true. In hybrids we observed the highest acquisition effectiveness and RNA copy numbers during Siberian TBEV subtype transmission. The efficiency of trans-stadial transmission of both TBEV subtypes was similar in hybrids and parental species. After the second trans-stadial TBEV transmission, a significant increase in ticks’ infection rates was observed only in specific subtype-tick combination. Our data demonstrate the possible features of TBEV circulation in the I. ricinus and I. persulcatus sympatry area.
Developing a music-based digital therapeutic to help manage the neuropsychiatric symptoms of dementia
Authors: Russo Frank A. , Mallik Adiel , Thomson Zoe , de Raadt St. James Alexander , Dupuis Kate , Cohen Dan
Published: January 2023

The greying of the world is leading to a rapid acceleration in both the healthcare costs and caregiver burden that are associated with dementia. There is an urgent need to develop new, easily scalable modalities of support. This perspective paper presents the theoretical background, rationale, and development plans for a music-based digital therapeutic to manage the neuropsychiatric symptoms of dementia, particularly agitation and anxiety. We begin by presenting the findings of a survey we conducted with key opinion leaders. The findings highlight the value of a music-based digital therapeutic for treating neuropsychiatric symptoms, particularly agitation and anxiety. We then consider the neural substrates of these neuropsychiatric symptoms before going on to evaluate randomized control trials on the efficacy of music-based interventions in their treatment. Finally, we present our development plans for the adaptation of an existing music-based digital therapeutic that was previously shown to be efficacious in the treatment of adult anxiety symptoms.
Research on the spatial characteristics of urban integration from multi-dimensions: A case study in the Guangzhou-Qingyuan metropolitan area
Authors: Tang Bo , Huang Zhangdi
Published: January 2023

The urban integration of metropolitan areas is an important embodiment of the high-quality development of urban agglomerations. Using the data of 2012–2020 NPP-VIIRS night light, social economy, OSM, and Baidu migration, etc., we explore the characteristics of Guangzhou-Qingyuan’s urban integration from four dimensions, such as economic development, industrial structure, transportation facilities, and public services using the methods such as geographical information method, commodity urban integration index, industrial structure similarity index, etc. The research results are as follows: The spatial pattern of economic development in the Guangzhou-Qingyuan differs greatly, but with the advancement of the integration process, regional economic exchanges have been enhanced; the commodity urban integration index is on the increase, the degree of market segmentation is gradually shrinking, and the level of commodity market urban integration is constantly improving. The industrial integration of the Guang-Qing area has an obvious effect. Although the index of similarity of industrial structure is high, there is a trend of gradual convergence and coordination; the leading industries are not the same, and the industrial demands are complementary to realize the coordinated development of the industry. The trend of the transportation urban integration in Guangzhou-Qingyuan is obvious, and the road network develops rapidly, but the travel time between the two cities is still relatively long. The transportation accessibility presents a circle-layer structure on the whole, and the transportation accessibility at the boundary area between the two cities has been greatly improved. Due to the close links between the historical foundation and social culture, inter-city people flow frequently, the public service facilities in Guangzhou-Qingyuan show an obvious trend of urban integration, but the relevant infrastructure needs to be improved urgently.
Analysis of ecosystem resilience in Jiuzhaigou Valley Scenic Area under the effect of geohazards
Authors: Sui Haixia , Liu Chang , Ye Chengming , Xu Xiaolong , Sui Tianbo
Published: January 2023

The effects of geohazards on the ecological environment and ecological spatial pattern have received wide attention from scholars. However, the positive role played by ecological restoration projects on the environment and in the reduction of geohazards has usually been neglected. Jiuzhaigou Valley Scenic Area is a world natural heritage area, has a high incidence of geohazards, and is a demonstration area for ecological restoration projects. Based on remote sensing technology, this paper adopted an InVEST model (Integrated Valuation of Ecosystem Services and Tradeoffs) and ecological landscape index to extract information about spatio-temporal changes in Jiuzhaigou from 2013 to 2020. This study utilized a quantitative analysis of the ecological recoverability of Jiuzhaigou in cases of artificial restoration and spontaneous restoration under different types of geohazards. Results showed that forests play a vital role in maintaining and controlling habitat quality; artificial restoration can significantly ameliorate the impact of geohazards on the scenic area. As of 2020, the forested scenic area recovered 3.868 km2, and the habitat quality index rebounded to 98.88% of the historical high. The ecological restoration project significantly shortened the scenic area recover time of its ecosystem service capability.
Evolutionary mechanisms of the strong winds associated with an intense cold wave event and their effects on the wind power production
Authors: Ma Hui , Li Guoqing , Zeng Chuikuan , Wang Fei , Jin Shuanglong , Fu Shenming
Published: January 2023

Cold wave events (CWEs) often cause major economic losses and serious casualties in the cold seasons, making CWEs among the most significant types of disastrous weather. Previous studies have mainly focused on disasters due to abrupt drops in surface temperatures, with less discussion of the strong winds associated with CWEs. Based on an intense CWE that occurred in late December 2020, we investigated the evolutionary mechanisms of the associated strong winds in terms of kinetic energy (KE) budget and evaluated the effects of this CWE on wind power production based on quantitative comparisons with the mean state. The results showed that the CWE occurred under favorable background conditions, which were characterized by a southward-moving transversal trough and a southeastward-moving shortwave trough in the middle troposphere. The surface high ridge that formed around Lake Baikal and the cold front around the southern periphery of the ridge were key factors related to the CWE evolution. The positive work carried out on the horizontal wind by the pressure gradient force that linked a lower tropospheric high-pressure ridge inland and a low-pressure trough offshore and the downward momentum transportation due to the descending motions behind the cold front dominated the enhancement and sustainment of the CWE-associated strong winds. The CWE contributed to wind power production by 1) increasing the wind power density (by an average of ∼1.05-fold) and 2) improving the availability of the wind to generate power, as it reduced the percentage of zero wind power generation by ∼6.4%, while maintaining the high-wind-velocity cut-out percentage.