bluuebunny/crossref_metadata_2025 huggingface dataset:
GC-MS investigation of the chemical composition of honeybee drone and queen larvae homogenate
Authors: Isidorov Valery A. , Bakier Sławomir , Stocki Marcin
Published: June 2016

Honeybee larva homogenate appears to be underrated and insufficiently explored but this homogenate is an exceptionally valuable honeybee product. Drone larva homogenate is very nutritional due to its high content of proteins, free amino acids, lipids, and carbohydrates. Moreover, the biological characteristics of honeybee larvae indicate the presence of chemical substances that may be pharmacologically active. In spite of the above, the chemical composition of honeybee larva has not gained as much attention as that of other bee products. In this study, the chemical composition of honeybee brood homogenate has been investigated using gas chromatography/mass spectrometry. As a result, it was possible to isolate as many as 115 extractive organic compounds from 6 samples of crude queen and 9 samples of drone homogenate. The main groups of substances extracted from either type of homogenate were composed of free amino acids and carbohydrates. The relative content of amino acids in queen homogenate as well as the share of essential amino acids were found to be higher than in the drone homogenate. Disaccharide trehalose was the dominant sugar in the queen larvae, whilst glucose prevailed in the drone larvae. Comparative chemical analyses of honeybee queen and drone larva homogenates have allowed us to make a preliminary inference about a higher overall value of the former.
Physico-chemical characterization and antibacterial activity of different types of honey tested on strains isolated from hospitalized patients
Authors: Junie Lia M. , Vică Mihaela L. , Glevitzky Mirel , Matei Horea V.
Published: June 2016

The first aim of the study was to compare the antibacterial activity of several types of honey of different origins, against some bacterial resistant strains. The strains had been isolated from patients. The second aim was to discover the correlations between the antibacterial character of honey and the physico-chemical properties of the honey. Ten honey samples (polyfloral, linden, acacia, manna, and sunflower) from the centre of Romania were tested to determine their antibacterial properties against the following bacterial species: Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Salmonella enterica serovar Typhimurium, Bacillus cereus, Bacillus subtilis, and Listeria monocytogenes. Bacterial cultures in nutrient broth and the culture medium Mueller-Hinton agar were used. The susceptibility to antibiotics was performed using the disk diffusion method. All honey samples showed antibacterial activity on the isolated bacterial strains, in particular polyfloral (inhibition zone 13-21 mm in diameter) - because it is the source of several plants, and manna (inhibition zone 13-19.5 mm in diameter), and sunflower (inhibition zone 14-18.5 mm in diameter). Pure honey has a significant antibacterial activity against some bacteria which are resistant to antibiotics. Bacterial strains differed in their sensitivity to honeys. Pseudomonas aeruginosa and Staphylococcus aureus were the most sensitive. The present study revealed that honey antibacterial activity depends on the origin of the honey. We also found that there was a significant correlation between antibacterial activity of honeys and the colour of the honey but not between acidity and pH. The statistical analysis showed that the honey type influences the antibacterial activity (diameter of the bacterial strains inhibition zones).
Critical Congenital Heart Diseases as Life-threatening Conditions in the Emergency Room
Authors: Togănel Rodica
Published: June 2016

Critical congenital heart disease (CHD) represents a special type of cardiovascular emergency due to the complexity of the associated pathology. In many cases, urgent surgery or catheter-based intervention is required as the condition might be life-threatening. In patients with ductal-dependent lesions, closure of the patent ductus arteriosus (PDA) within the first few days postpartum, can cause sudden clinical deterioration with potentially life-threatening consequences. The diagnostic challenges, clinical presentation and particularities related to the closure of PDA in life-threatening critical CHD are presented.
How To Treat Spontaneous Coronary Artery Dissection
Authors: Sitar Jan , Groch Ladislav , Hlinomaz Ota , Rezek Michal , Seménka Jiří
Published: June 2016

Spontaneous coronary artery dissection (SCAD) is a rare disease, occurring most often in young women, around 40 years of age. Usually there is the presence of several predisposing factors. Diagnosis is made using coronary angiography, optical coherence tomography (OCT) or autopsy. Optical coherence tomography allows a precise diagnosis to be made, identifying as it can, a coronary artery intramural haematoma prior to the occurrence of a dissecting lesion. The case of a 52-year-old woman with SCAD of unknown etiology is reported.
A Holistic Synthesis of the Organisation Theories
Authors: Goldman Geoff , Callaghan C.W.
Published: June 2016

Much literature exists on the topic of ‘organisation’. Many different academic disciplinary areas stake their claim to aspects of business organisation. The social sciences offer many different perspectives of the phenomena associated with it; as different lenses, through which the object is perceived very differently. According to social constructivists, the business organisation is socially constructed. For psychologists, it exists at the nexus of individual human needs. For economists, the business organisation operates as a mechanism responding to signals of supply and demand. In this paper the business organisation is re-imaged as an entity existing within, and comprised of, chaotic systems. On the basis of a synthesis of seminal theory this paper attempts to offer a holistic perspective of business organisations; that ‘pulls together’ these multidisciplinary perspectives. On the basis of this synthesis, it is argued that the organisational context is inherently endogenous, and that qualitative research methods might offer management scientists a more valid perspective of the relationships within organisations than empirical methods can.
Visual Code Across Borders. Visual Communication as the Answer to Intercultural Management Dilemmas
Authors: Waszkiewicz-Raviv Alicja
Published: June 2016

The paper focuses on the visual communication channel and it’s practical implications to the intercultural management practice. Introducing theoretical framework provides arguments for the increasing role of the pictures in the image economy, where esthetics and visual branding are the core elements. Two main fields of business applications of visual channels are drawn in the article: external consumers communication and internal organizational communication. Author’s definition of visual marketing communication (VMC) is provided and the semiotic approach is recommended for the culturally rooted customer communication that increases consumption globally, while information design and infographics are the visual messages suggested for the second field, which is internal, employees communication management.
Effect of intramuscular cholecalciferol megadose in children with nutritional rickets
Authors: Bothra Meenakshi , Gupta Nandita , Jain Vandana
Published: June 2016

The treatment practices for vitamin D deficiency rickets are highly variable. Though a single intramuscular (IM) megadose of vitamin D is economical, and ensures good compliance, it poses the risk of hypervitaminosis D. This observational study was conducted to assess the duration of effect and safety of single IM megadose of cholecalciferol in the treatment of vitamin D deficiency rickets.

Children younger than 14 years with rickets were enrolled. Baseline investigations included radiograph of wrists and estimation of serum calcium, phosphate, alkaline phosphatase (ALP), 25(OH) vitamin D and parathormone (PTH) levels. All children received a single IM megadose of vitamin D3. Biochemical parameters were re-evaluated at 1.5, 3 and 6 months after the megadose and the values were compared to the baseline.

We enrolled 21 children, out of which nine remained under active follow-up till 6 months. Radiological evidence of rickets was present in all 21 children, 14 had hypocalcemia at the time of presentation. After IM cholecalciferol megadose, median 25 hydroxy vitamin D [25(OH)D] level remained significantly more than the baseline till 6 months after the megadose. At 1.5 months after the vitamin D megadose, three (30%) of the children were found to develop toxic levels of vitamin D (>150 ng/mL), although none had hypercalcemia or any clinical manifestation of vitamin D toxicity. At 3 months and 6 months after the megadose, 25(OH)D levels remained in the sufficient range (20–100 ng/mL) in seven out of the eight children who came for follow-up.

A single IM megadose of vitamin D may be effective in significantly increasing the 25(OH)D levels for at least 6 months in children with rickets, but elevation of 25(OH)D to toxic range raises concern regarding its safety.
Antifungal activity of essential oils on Aspergillus parasiticus isolated from peanuts
Authors: Yooussef Mina M. , Pham Quyen , Achar Premila N. , Sreenivasa Marikunte Yanjarappa
Published: June 2016

Aspergillus parasiticus is one of the most common fungi which contaminates peanuts by destroying peanut shells before they are harvested and the fungus produces aflatoxins. The aim of this study was to evaluate the antifungal activities of seventeen essential oils on the growth of the aflatoxigenic form of A. parasiticus in contaminated peanuts from commercial outlets in Georgia. The agar dilution method was used to test the antifungal activity of essential oils against this form of A. parasiticus at various concentrations: 500; 1,000; 1,500; 2,000; 2,500 ppm. Among the seventeen essential oils tested, the antifungal effect of cinnamon, lemongrass, clove and thyme resulted in complete inhibition of mycelial growth. Cinnamon oil inhibited mycelial growth at ≥ 1,000 ppm, lemongrass and clove oils at ≥ 1,500 ppm and thyme at 2,500 ppm. However, cedar wood, citronella, cumin and peppermint oils showed partial inhibition of mycelial growth. Eucalyptus oil, on the other hand, had less antifungal properties against growth of A. parasiticus, irrespective of its concentration. Our results indicate that the aflatoxigenic form of A. parasiticus is sensitive to selected essential oils, especially cinnamon. These findings clearly indicate that essential oils may find a practical application in controlling the growth of A. parasiticus in stored peanuts.
Stephanitis takeyai and S. rhododendri (Heteroptera: Tingidae) in Slovakia: first record and economic importance
Authors: Barta Marek , Bibeň Tomáš
Published: June 2016

This is the first report on the occurrence of andromeda lace bug, Stephanitis (Stephanitis) takeyai Drake and Maa, 1955, and rhododendron lace bug, Stephanitis (Stephanitis) rhododendri Horvath, 1905, in Slovakia. Syntopic colonies of both species were found on rhododendron shrubs (Rhododendron sp.) in south-western Slovakia in 2015. The feeding of the lace bugs resulted in damage to infested rhododendrons. Leaves turned yellow and brown, prematurely dropped what led to continuous drying up of twigs and the whole plants. Details on morphology of adult stages of the two species, description of damage symptoms and economic importance of these pests are presented and discussed.
Analysis of Sediments in the North-East Morainic Upland Edge Zone in the Vicinity of Piaski Pomorskie (West Pomerania, NW Poland)
Authors: Paluszkiewicz Ryszard , Paluszkiewicz Renata
Published: June 2016

the aim of this article is the description of lithofacies characteristics of sediments forming the north-east part of the morainic upland edge zone in the vicinity of Piaski Pomorskie (west Pomerania). the paper undertake also an attempt to reconstruct paleogeographical conditions of the formation of moranic uppland edge. The diversification of glaciofluvial and fluvial processes during the phase of stagnation and recession of uppervistulian ice-sheet in the vicinity of Piaski Pomorskie (western Pomerania) led to the formation of a morainic upland edge distinctly marked in morphology The edge zone separates the undulating moraine plateau from a lower situated Dębnica River Valley. This area is mostly formed by fine-grained sands with occasional layers of a coarser fraction of gravel and coarse- and medium-grained sands. The observed type of low-angle cross-stratification and trough cross-stratification indicates the dominance of diversified energy depositional environment with considerable power of water as transporting medium. the research area was formed at the front of the ice-sheet, which receded from the nearby reach of the Pomeranian Phase of the weichselian glaciation.
Tourist Behaviour of Junior High School Students of the Selected Voivodeships in Poland: the Sociodemographic Context
Authors: Lubowiecki-Vikuk Adrian P. , Podgórski Zbigniew
Published: June 2016

Leisure-time behavior, including tourist activity among contemporary adolescents has raised great interest of scientists and the representatives of the tourism industry. Not only it is important to estimate the rate of tourism activity among adolescents, but also it is necessary to bear in mind the analysis of behavior shaped on account of their gender, place of residence, or level of education. An attempt to conduct such a study was made on the basis of survey data obtained within the group of 1,067 junior high school students of the selected voivodeships in Poland. The results obtained clearly indicate that almost 1/4 of the students surveyed had not participated in tourist trips. This was particularly noticeable in the case of boys and students living in rural areas. it is important to take broader steps to stimulate young people’s needs for tourism and sightseeing. First of all, from the family which is considered a social institution, it is expected to raise young generations in the spirit of tourism and active leisure. Family’s contemporary problems: increasing poverty, or even its (partial) marginalization are commonly disregarded. A systemic approach (support for families by schools, social organizations, and government units) appears to be a successful solution, but it is a long-term and complex process.
Environmental Assessment of an Abandoned Briquette Factory – A Case Study at Nagymányok Area, Former Industrial Zone
Authors: Halász Amade , Dezső József , Poor Viktoria
Published: June 2016

The study is focused on environmental assessments of impacts by former briquette factory at the Nagymányok area in South Hungary. The (former) industrial zone is located in a northern valley of the Eastern Mecsek Mountains. Until the 1990s this company was the largest briquette factory in Hungary and the demolition works are still incomplete. former investigations were based on only five samples. our sampling sites were selected on the basis of the source of the contaminations and then we covered the whole area in equal distribution. We used the A1-F6 codes for the sample places. We have started from southwest to northeast. The samples were analyzed for Total Petrol Hydrocarbons (TPHs), Polycyclic Aromatic Hydrocarbons (PAHs) and for heavy metals. The area was heavily contaminated by TPHs and moderately heavy metals (such as Cu, Cr, Zn and Pb). Highest contaminant concentrations were found around the former industrial buildings, especially between the boiler-house and the coal-pillbox. In the industrial area the mean of the detected values is below the upper limit of the legal exposure values, but among the former industrial buildings higher (e.g. toxic level) concentration values were detected in multiple samples. Based on our investigation the pollutant can be transported by wind or by water on the surface (stream bed) or underground. The hazardous material can easily reach some part of the city, therefore reclamation is necesarry.
Using Geobia and Data Fusion Approach for Land use and Land Cover Mapping
Authors: Wężyk Piotr , Hawryło Paweł , Szostak Marta , Pierzchalski Marcin , Kok Roeland De
Published: June 2016

Land Use and Land Cover (LULC) maps play an important role in an environmental modelling, and for many years efforts have been made to improve and streamline the expensive mapping process. The aim of the study was to create LULC maps of three selected water catchment areas in South Poland using a Geographic Object-Based Image Analysis (GEOBIA) in order to highlight the advantages of this innovative, semi-automatic method of image analysis. the classification workflow included: multi-stage and multi-scale analyses based on a data fusion approach. Input data consisted mainly of BlackBridge (RapidEye) high resolution satellite imagery, although for distinguishing particular LULC classes, additional satellite images (LANDSAT TM5) and GIS-vector data were used. Accuracy assessment of GEOBIA classification results varied from 0.83 to 0.87 (kappa), depending on the specific catchment area. The main recognized advantages of GEOBIA in the case study were: performing of multi-stage and multi-scale image classification using different features for specific LULC classes and the ability to using knowledge-based classification in conjunction with the data fusion approach in an efficient and reliable manner.
Temporal Variations of Stroke Occurence
Authors: Simović Snežana , Aleksic Dejan , Matic Tatjana Boskovic , Vesic Katarina , Toncev Slavco , Drakulic Svetlana Miletic , Tončev Gordana
Published: June 2016

Stroke is one of leading causes of death worldwide. Different frequency of stroke occurence is observed in days of the week and months in the year, and incidence of stroke has irregular time pattern. We analyzed 516 patients who had acute stroke and were treated in Clinic of Neurology, Clinical Center Kragujevac from January 1, 2013 to January 1, 2014, mean age 72,11±11,52. Statistical analysis is conducted out using the SPSS software version 20.0. We used descriptive statistic, student T-test, chi-square or Fisher exact test.

Friday is day we found the most IS and all stroke types occurences, and Wednesday is day we found the most IS in men. We found the most strokes in women younger than 65 years on Wednesday, but in women older than 65 years on Friday. Monday is day with the most admissions to hospital for patients with IS, and we observed that there is average delay in the refering to the doctor for 1.80±1.44 days. Friday is the day with the most ICH symptom beginings and the most admissions to the hospital, and Saturday is the day with the least symptom beginings and admissions to the hospital in the case of IS and ICH. The most IS occured in winter (in Decembar), and the least in summer (in August). The most ICH occured in May, and the least in July and October.

We confirmed that there is a significant weekly variability in the IS symptom onset day.
Thrombotic Thrombocytopenic Purpura: Etiopathogenesis, Diagnostics and Basic Principles of Treatment
Authors: Todorović Željko , Jovanovic Milena , Todorovic Dusan , Petrovic Dejan , Djurdjevic Predrag
Published: June 2016

Thrombotic thrombocytopenic purpura (TTP) is a clinical syndrome that manifests with thrombocytopenia, microangiopathic haemolytic anaemia and symptoms and signs of kidney and brain damage, but it rarely involves other organs. The main pathophysiological cause of TTP is diminished metalloproteinase ADAMTS13 activity; the main function of ADAMTS13 is to degrade large multimers of the von Willebrand factor. Diminished activity of ADAMTS13 is caused either by a genetic mutation in the gene that codes ADAMTS13 (congenital TTP) or by antibodies that block ADAMTS13 enzyme activity or accelerate the degradation of ADAMTS13 (acquired TTP). Clinically, TTP presents most frequently with signs and symptoms of brain and kidney damage with concomitant haemorrhagic syndrome. TTP is suspected when a patient presents with a low platelet count, microangiopathic haemolytic anaemia (negative Coombs tests, low haptoglobine concentration, increased serum concentration of indirect bilirubin and lactate dehydrogenase, increased number of schysocytes in peripheral blood) and the typical clinical presentation. A definitive diagnose can be made only by measuring the ADAMTS13 activity. The differential diagnosis in such cases includes both typical and atypical haemolytic uremic syndrome, disseminated intravascular coagulation, HELLP syndrome in pregnant women and other thrombotic microangiopathies. The first line therapy for TTP is plasma exchange. In patients with acquired TTP, in addition to plasma exchange, immunosuppressive medications are used (corticosteroids and rituximab). In patients with hereditary TTP, the administration of fresh frozen plasma is sometimes required.
Effects of Plant Lectins on Human Erythrocyte Agglutination
Authors: Zubcevic Nadja , Damir Suljevic , Focak Muhamed , Rukavina Dunja
Published: June 2016

Plant lectins are carbohydrate binding proteins or phytohaemagglutinins present in most plants, especially seeds and tubers, which include cereals, potatoes and beans. Lectins have great significance in the diet because of their involvement in gastrointestinal difficulties and erythrocyte agglutination. Blood agglutination activity against A, B, AB and O groups was shown after exposing blood to extracts obtained from 55% of tested plants, while in 45% of plants, agglutination was absent. The results of our study have shown that in humans, 40% of plant extracts exhibited activity against A, 40% of plant extracts exhibited activity against B, and 50% of plant extracts exhibited activity against AB and O groups in humans. The concentration of plant lectins depends on the part of the plant. Lectins from the seeds of certain plants cause the greatest percentage of erythrocyte agglutination, while the lowest agglutination was caused by plant bulbs and leaves. However, lectins derived from all plant species of the family Fabaceae agglutinated erythrocytes of all blood types to some extent.
The Effect of the Antioxidant Drug U-74389G on Uric Acid Levels during Ischemia Reperfusion Injury in Rats
Authors: Tsompos Constantinos , Panoulis Constantinos , Toutouzas Konstantinos , Triantafyllou Aggeliki , Zografos George , Papalois Apostolos
Published: June 2016

This experimental study examined the effect of the anti-oxidant drug U-74389G in a rat model using a renal ischaemia-reperfusion (IR) protocol. The effects of the molecule were studied biochemically by assessing mean serum uric acid levels (SUA). In total, 40 rats (mean weight = 231.875 g) were used in the study. SUA levels were measured at 60 min of reperfusion for groups A and C and at 120 min of reperfusion for groups B and D. The drug U-74389G was administered only in groups C and D. U-74389G administration non-significantly increased the SUA levels by 15.43%±9.10% (p=0.096) at the representative endpoint of 1.5 h. The reperfusion time non-significantly decreased the SUA levels by 13.61%±9.18% (p=0.126). However, the interaction of U-74389G administration and reperfusion time non-significantly increased the SUA levels by 4.78%±5.64% (p= 0.387). Whether it interacted with the reperfusion time, U-74389G administration non-significantly increased SUA levels. It seems that U-74389G cannot reverse injury to IR tubular epithelial cells within 2 hours.
Humor étnico y discriminación enLa paisana Jacinta
Authors: Heros Susana de los
Published: June 2016

Los textos televisivos interpretan y analizan la realidad circundante e influyen en la visión que la audiencia tiene del mundo (Harwood y Giles, 1992, p. 409; Mintz, 1985). Es más, los programas cómicos basados en la burla y el sarcasmo hacia grupos étnicos minoritarios refuerzan estereotipos negativos y promueven la discriminación cultural (Billig, 2005). En este artículo se estudia el humor étnico enLa paisana Jacinta(1999–2015). Esta serie peruana ha sido acusada de racista por diversas personas y grupos, entre ellos, la excongresista indígena Hilaria Supa, LUNDU (Centro de Estudios y Promoción Afroperuanos) y CHIRAPAQ (Centro de Culturas Indígenas delPerú). Primero, se analizan las estrategias pragmático-lingüísticas empleadas en la construcción del humor étnico en una selección de diálogos y monólogos de Jacinta, el personaje principal de la serie. Para ello, se utiliza laTeoría General del Humor Verbal(Attardo y Raskin, 1991; Attardo 2001; Attardo, Hempelmann y Maio, 2002; Attardo, 2008). Asimismo, dado que todo texto es multimodal, se tiene también en cuenta cómo imágenes, gestos, y elementos musicales y prosódicos en la serie contribuyen en la producción de la comicidad (Kress 2010, 2012). Finalmente, a partir de estos resultados, se examina el contenido cómico del programa desde una perspectiva crítica (Billig, 2005) para determinar si este es discriminatorio.
DIAGNOSIS OF ENDOCRINE DISEASE: The diagnostic performance of adrenal biopsy: a systematic review and meta-analysis
Authors: Bancos Irina , Tamhane Shrikant , Shah Muhammad , Delivanis Danae A , Alahdab Fares , Arlt Wiebke , Fassnacht Martin , Murad M Hassan
Published: June 2016

Objective

To perform a systematic review of published literature on adrenal biopsy and to assess its performance in diagnosing adrenal malignancy.

Methods

Medline In-Process and Other Non-Indexed Citations, MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trial were searched from inception to February 2016. Reviewers extracted data and assessed methodological quality in duplicate.

Results

We included 32 observational studies reporting on 2174 patients (39.4% women, mean age 59.8 years) undergoing 2190 adrenal mass biopsy procedures. Pathology was described in 1621/2190 adrenal lesions (689 metastases, 68 adrenocortical carcinomas, 64 other malignancies, 464 adenomas, 226 other benign, 36 pheochromocytomas, and 74 others). The pooled non-diagnostic rate (30 studies, 2013 adrenal biopsies) was 8.7% (95%CI: 6–11%). The pooled complication rate (25 studies, 1339 biopsies) was 2.5% (95%CI: 1.5–3.4%). Studies were at a moderate risk for bias. Most limitations related to patient selection, assessment of outcome, and adequacy of follow-up. Only eight studies (240 patients) could be included in the diagnostic performance analysis with a sensitivity and specificity of 87 and 100% for malignancy, 70 and 98% for adrenocortical carcinoma, and 87 and 96% for metastasis respectively.

Conclusions

Evidence based on small sample size and moderate risk of bias suggests that adrenal biopsy appears to be most useful in the diagnosis of adrenal metastasis in patients with a history of extra-adrenal malignancy. Adrenal biopsy should only be performed if the expected findings are likely to alter the management of the individual patient and after biochemical exclusion of catecholamine-producing tumors to help prevent potentially life-threatening complications.
The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1
Authors: Luef Birgit , Handle Florian , Kharaishvili Gvantsa , Hager Martina , Rainer Johannes , Janetschek Günter , Hruby Stephan , Englberger Christine , Bouchal Jan , Santer Frédéric R , Culig Zoran
Published: June 2016

Due to the urgent need for new prostate cancer (PCa) therapies, the role of androgen receptor (AR)-interacting proteins should be investigated. In this study we aimed to address whether the AR coactivator nuclear receptor coactivator 1 (NCOA1) is involved in PCa progression. Therefore, we tested the effect of long-termNCOA1knockdown on processes relevant to metastasis formation. [3H]-thymidine incorporation assays revealed a reduced proliferation rate in AR-positive MDA PCa 2b and LNCaP cells upon knockdown ofNCOA1, whereas AR-negative PC3 cells were not affected. Furthermore, Boyden chamber assays showed a strong decrease in migration and invasion uponNCOA1knockdown, independently of the cell line’s AR status. In order to understand the mechanistic reasons for these changes, transcriptome analysis using cDNA microarrays was performed. Protein kinase D1 (PRKD1) was found to be prominently up-regulated byNCOA1knockdown in MDA PCa 2b, but not in PC3 cells. Inhibition ofPRKD1reverted the reduced migratory potential caused byNCOA1knockdown. Furthermore, PRKD1 was negatively regulated by AR. Immunohistochemical staining of PCa patient samples revealed a strong increase in NCOA1 expression in primary tumors compared with normal prostate tissue, while no final conclusion could be drawn for PRKD1 expression in tumor specimens. Thus, our findings directly associate the AR/NCOA1 complex withPRKD1regulation and cellular migration and support the concept of therapeutic inhibition of NCOA1 in PCa.
El mito del origen
Authors: Rodríguez Barraza Adriana
Published: June 2016

El presente artículo presenta una lectura desde Platón y Johann Gottfried Herder vertebrada por la figura del mito. Dentro de la constitución colectiva propuesta por ambos pensadores el mito es un recurso trascendental. El primero, que propone un sistema de orden social, basa su método persuasivo a través del uso del mito que va más allá de ser un simple recurso expresivo. El segundo, con una crítica a la Francia cosmopolita, plantea la idea de la identidad nacional cimentada en el mito originario. Es así como dos perspectivas permiten ver la imagen del mito del origen y su relación con el Estado como una noción vital en la construcción ya no solo cultural, sino social e histórica de toda civilización: el mito como puerta de acceso a lo primigenio, aquello que se explica más allá de las palabras, y el espejo a través del cual puede verse el surgimiento de toda sociedad.http://dx.doi.org/10.15304/ag.35.2.2412
Against Philo’s interpretation of conditional. The case of Aristotle´s thesis
Authors: López-Astorga Miguel
Published: June 2016

There is an Aristotelian thesis that can be considered controversial. That is the thesis related to a denied conditional with only one propositional variable and in which, in addition, one of its clauses is also denied. While the thesis is not a tautology, people tend to accept it as true. Pfeifer’s approach can account for this fact. However, I try to show that this problem can also be explained from other alternative frameworks, in particular, from that of the mental models theory, that of López-Astorga based on the pragmatic phenomenon of conditional perfection, and that of the mental logic theory. Likewise, I indicate the difficulties regarding Aristotle’s thesis of the mental models theory and López-Astorga’s proposal, and conclude that the account of the mental logic theory is the strongest alternative to Pfeifer’s explanation and that what is clearly obvious is that conditional should not be materially interpreted.http://dx.doi.org/10.15304/ag.35.2.2542
Imaginación y respuesta emotiva en obras de ficción: una aproximación desde la filosofía de David Hume
Authors: Guerrero Leandro
Published: June 2016

El trabajo estudia la teoría humeana de la creencia en vistas a una caracterización preliminar de la noción de ficción dentro de su teoría y a un vínculo con sus tesis estéticas, especialmente con la posibilidad de apreciar una obra de arte y de poder tener una respuesta emotiva a ella. Para ello, en primer lugar, caracterizamos la noción de creencia y la de ficción en relación a la imaginación. En segundo lugar, discutimos la noción de “sistema poético” y su relevancia a la hora de aportar a la ficción la vivacidad necesaria para constituir una experiencia estética agradable. El propósito principal es ubicar a Hume dentro del debate contemporáneo en torno a la “paradoja de la ficción”, bajo el supuesto de que tal inserción podría implicar algún aporte de relevancia teórica.http://dx.doi.org/10.15304/ag.35.2.2888
Shariah Bond as Financial Instrument For Local Government
Authors: Rahmayati Anim
Published: June 2016

This study aims to analyse the potential of sharia bonds in the region as an alternative to local financing. This research is a kind of literary descriptive qualitative research using SWOT analysis. The results of this study indicate that in the area of sharia bonds is an alternative worth considering regional funding compared to other funding. Support policy, very large financing needs for region infrastructure development, the market potential in the area of sharia bonds is an opportunity for local governments in Indonesia to immediately issue sharia bonds in the area.DOI:  10.15408/sjie.v5i1.3126
Residential Moving and Preventable Hospitalizations
Authors: Hutchings Hayley A. , Evans Annette , Barnes Peter , Demmler Joanne C. , Heaven Martin , Healy Melanie A. , James-Ellison Michelle , Lyons Ronan A. , Maddocks Alison , Paranjothy Shantini , Rodgers Sarah E. , Dunstan Frank
Published: June 2016

OBJECTIVES:

To investigate the association between moving home in the first year of life and subsequent emergency admissions for potentially preventable hospitalizations.

METHODS:

We undertook a cohort analysis of linked anonymized data on 237 842 children in the Welsh Electronic Cohort for Children. We included children born in Wales between April 1, 1999 and December 31, 2008. The exposure was the number of residential moves from birth up to 1 year. The main outcome was emergency admissions for potentially preventable hospitalizations (PPH) between the age of 1 and 5 years.

RESULTS:

After adjustment for confounders, we identified that moving home frequently in the first year of life was associated with an increased risk of emergency PPH between the ages of 1 and 5 when compared with not moving. We found significant differences associated with ≥2 moves for the following: ear, nose, and throat infections (incidence risk ratio [IRR], 1.44; 95% confidence interval [CI], 1.29–1.61); convulsions/epilepsy (IRR, 1.58; 95% CI, 1.23–2.04); injuries (IRR, 1.33; 95% CI, 1.18–1.51); dehydration/gastroenteritis (IRR, 1.51; 95% CI, 1.21–1.88); asthma (IRR, 1.61; 95% CI, 1.19–2.16); influenza/pneumonia (IRR, 1.15; 95% CI, 1.00–1.32); and dental conditions (IRR, 1.30; 95% CI, 1.03–1.64) for ≥1 moves.

CONCLUSIONS:

Children who move home in the first year of life are at substantially increased risk of emergency admissions for PPH in early childhood. Additional research that focuses on enhancing health and social support services for highly mobile families, educating parents about safety risks, and improving housing quality is warranted.
Pertussis Antibody Concentrations in Infants Born Prematurely to Mothers Vaccinated in Pregnancy
Authors: Kent Alison , Ladhani Shamez N. , Andrews Nick J. , Matheson Mary , England Anna , Miller Elizabeth , Heath Paul T. ,   on behalf of the PUNS study group
Published: June 2016

BACKGROUND AND OBJECTIVES:

Maternal antenatal pertussis-containing vaccination is recommended for the prevention of neonatal pertussis, but the ability of maternal vaccination to protect premature infants is unknown. We hypothesized that that infants born prematurely to antenatally vaccinated women would have higher pertussis antibody concentrations than those born to unvaccinated women.

METHODS:

Mothers had been offered a combined tetanus, diphtheria, 5-component acellular pertussis, inactivated polio vaccine from 28 weeks’ gestation as part of their routine antenatal care. Premature infants of vaccinated and unvaccinated mothers enrolled in a randomized controlled trial of pneumococcal conjugate vaccine schedules had antibody concentrations (pertussis toxin, filamentous hemoagglutinin [FHA], and fimbriae 2 and 3) measured at 2 months (before primary vaccination), 5 months (1 month after primary vaccination), and 12 months of age.

RESULTS:

Mothers of 31 (19%) of 160 premature infants had received combined tetanus, diphtheria, 5-component acellular pertussis, inactivated polio vaccine in pregnancy. Compared with infants of unvaccinated mothers, those born to vaccinated mothers had significantly higher antibody concentrations at 2 months for all measured vaccine antigens (P < .001). The number of days between maternal vaccination and delivery and immunoglobulin G concentration at 2 months of age was positively correlated for pertussis toxin (P = .011) and FHA (P = .001). After primary immunization, infants of vaccinated mothers had significantly lower antibody concentrations for FHA (P = .003) compared with infants of unvaccinated mothers; these differences had resolved by 12 months of age.

CONCLUSIONS:

Maternal vaccination administered early in the third trimester may provide protection for infants born prematurely.
Sustentabilidade nas organizações: vantagens e desafios
Authors: Paz Fabio Josende , Kipper Liane Mahlmann
Published: June 2016

As organizações necessitam adotar políticas e práticas sustentáveis, ocasionando a busca por modelos sustentáveis. Assim este artigo buscou verificar as vantagens da utilização dos princípios da sustentabilidade nas organizações, bem como, detectar as principais dificuldades ao implantar um modelo sustentável, identificando a existência dos princípios descritos por Oliveira et al. (2012) e outros autores. Foi realizada uma revisão sistemática da literatura para entender o “estado da arte” relativo à sustentabilidade nas organizações e dados e informações foram coletados por meio da bibliometria realizada em artigos publicados em bases de periódicos. Observou-se que existe carência em termos de artigos publicados sobre sustentabilidade nas organizações e sobre modelos de sustentabilidade. Nos estudos encontrados e avaliados evidenciou-se a importância da sustentabilidade para as organizações com reflexos no seu melhor desempenho financeiro, no estímulo à inovação, à melhoria na gestão e no envolvimento do stakeholders em seus processos, como vantagens do uso da sustentabilidade e seus modelos nas organizações. Finalizando, identificou-se os seguintes desafios: necessidade de uma averiguação da maturidade da organização na utilização de metodologias sustentáveis e o preparo dos recursos humanos para a mudança organizacional.
História e narrativa fotográfica: o caso de “Migrant Mother”, de Dorothea Lange
Authors: Bosi Antonio De Pádua
Published: June 2016

Dorothea Lange, fotógrafa documentarista, fez uma série de fotos em 1936 sobre uma família de trabalhadores migrantes. A principal dessas fotos foi denominada “Migrant Mother” e tornou-se um ícone dos tempos da grande depressão. O objetivo deste artigo é discutir a produção do conhecimento histórico a partir dessa série de imagens e da experiência de Florence Thompson, a mulher que foi fotografada. Ao fazer isto tentarei problematizar a narrativa fotográfica e alguns dos procedimentos de Lange à luz da história e do ofício do historiador.
Tempo de Perdão? Uma leitura da utopia escatológica de Paul Ricoeur em A memória, a história e o esquecimento
Authors: Pereira Mateus Henrique Faria
Published: June 2016

Para refletir sobre a relação entre perdão e história, o texto propõe uma leitura da contribuição teórica elaborada por Paul Ricoeur no livro A memória, a história e o esquecimento. A hipótese é que o “perdão difícil”, proposto pelo filósofo como um “horizonte comum” da memória, da história e do esquecimento, pode ser lido como uma utopia. No entanto, essa utopia exige algumas pré-condições para a sua realização. Enfatizaremos uma dessas pré-condições: a justiça. A fim de delimitar e compreender essa pré-condição e também uma po-ética do perdão, procura-se refletir sobre algumas dimensões da relação entre perdão, justiça, memória, anistia e esquecimento. Ao final, destacamos algumas dificuldades da experiência do perdão tendo em vista a experiência histórica brasileira recente.
A representância do passado histórico em Paul Ricoeur: linguagem, narrativa, verdade .
Authors: Mendes Breno
Published: June 2016

A representação do passado histórico na obra de Paul Ricoeur é o objeto desse artigo. O caminho escolhido para a investigação passa por conceitos correlatos ao tema, como linguagem, narrativa e verdade. Delinearemos de maneira mais precisa os contornos da representação historiadora em Ricoeur, sobretudo, a partir do neologismo representância, cunhado pelo filósofo, além de considerarmos a recepção de sua teoria entre alguns historiadores. Por fim, em nossas considerações finais, analisaremos as implicações dessa reflexão na noção de verdade histórica.
O modelo e o retrato: Jaime Cortesão, a ‘História da Formação Territorial do Brasil’ e sua articulação com a ‘História da Cartografia brasileira’
Authors: Peixoto Renato Amado
Published: June 2016

importância a sua participação nos projetos de Estado e numa produção historiográfica ligada a este. Neste artigo, procuramos discernir sua contribuição à ‘Formação Histórica do Brasil’ como uma tomada de posição, no metajogo historiográfico português e brasileiro, e na relação com os interesses nacionais. Entendemos que esta ‘metaestratégia’ foi bem sucedida porque os insumos de seu trabalho, especialmente a cartografia, já faziam parte da ‘metalógica’ da historiografia brasileira e, por causa de ter dirigido seus interesses, gradualmente, a um ‘circuito de expressão’, que prestigiou e alavancou a sua obra.
The influence of nicotine in healing of small bowel anastomoses in rats: angiogenesis and miofibroblasts
Authors: Skinovsky James , Malafaia Osvaldo , Chibata Mauricio , Tsumanuma Fernanda , Panegalli Filho Flávio , Martins Marcus Vinícius Dantas de Campos
Published: June 2016

ABSTRACT Objective: to know the effect of nicotine on angiogenesis and myofibroblast formation in anastomoses of the small bowel of rats. Methods: we randomly divided 60 Wistar rats into the groups Nicotine (N) and control (C), according to the proposed treatment. Each group was subdivided into three subgroups according to the time interval used for the evaluation (7, 14 or 28 days). The N group with 30 animals received nicotine subcutaneously at a dose of 2mg/kg body weight, diluted in 0.3ml of 0.9% saline, twice daily for 28 days prior to the operation, and for more 7, 14 or 28 days, depending on the subgroup. The C group (also 30 animals) received only saline on the same conditions and time intervals. After 28 days we carried out an end-to-end anastomosis 10cm distal to the duodenojejunal flexure in each rat. After 7, 14 or 28 days after surgery, we euthanized ten animals of each group, sent specimens of the anastomosis areas, 1cm proximal to 1cm distal, to counting of blood vessels and myofibroblasts through immunohistochemical staining by the application of monoclonal anti-factor VIII antibodies and anti-smooth muscle alpha-actin. Results: the administration of nicotine led to the decrease in the number of blood vessels measured on the 28th postoperative day and the number of myofibroblasts measured on the seventh day following completion of the anastomoses. Conclusion: administration of nicotine was deleterious on angiogenesis and myofibroblast formation in rats' small intestine anastomoses.
Extended pelvic resections for the treatment of locally advanced and recurrent anal canal and colorectal cancer: technical aspects and morbimortality predictors aftet 24 consecutive cases
Authors: Mesquita Neto José Wilson Benevides de , Machado Davy Bruno , Macedo Dárcio Jânio , Cordeiro Diego Fonseca , Brito Eurivaldo Valente de , Costa Marcelo Leite Vieira
Published: June 2016

ABSTRACT Objective: to evaluate the profile of morbidity and mortality and its predictors related to extensive pelvic resections, including pelvic exenteration, to optimize the selection of patients and achieve better surgical results. Methods: we performed 24 major resections for anorectal pelvic malignancy from 2008 to 2015 in the Instituto do Câncer do Ceará. The factors analyzed included age, weight loss, resected organs, total versus posterior exenteration, angiolymphatic and perineural invasion, lymph node metastasis and overall and disease-free survival. Results: the median age was 57 years and the mean follow-up was ten months. Overall morbidity was 45.8%, with five (20.8%) serious complications. There were no deaths in the first 30 postoperative days. The median overall survival was 39.5 months, and disease-free survival, 30.7 months. Concomitant resection of the bladder was an isolated prognostic factor for higher risk of complications (87.5% vs. 26.7%, p = 0.009). Angiolymphatic invasion and lymph node metastasis did not reach significance with respect to disease-free survival. Conclusion: treatment of advanced anorectal tumors is challenging, often requiring combined resections, such as cystectomy and sacrectomy, and complex reconstructions. The magnitude of the operation still carries a high morbidity rate, but is a procedure considered safe and feasible, with a low mortality and adequate locoregional tumor control when performed in referral centers.
Development of a strategy of physician-patient relationship for improving care for patients with disorders of sex development: a qualitative study
Authors: Telles-Silveira Mariana , Knobloch Felicia , Kater Claudio Elias
Published: June 2016

ABSTRACT: CONTEXT AND OBJECTIVE: Care for patients with disorders of sex development (DSD) should be provided in integrated-care centers by a multidisciplinary team. Implementation of this project within the teaching clinic routine presents several challenges: 1) difficulties in relationships between the medical team and patients and their families; 2) age, ethnic and cultural differences; 3) DSD-related prejudice; and 4) physicians' anxiety. We report on a psychologist's work strategy that focused on creating arrangements that could contribute towards development of the relationship between the medical team and patients and their families, as a way of preparing the clinical staff to manage treatment of adult DSD patients. DESIGN AND SETTING: Prospective qualitative study. METHODS: Between February 2010 and April 2015, we conducted a qualitative study in the Adrenal Outpatient Clinic of Escola Paulista de Medicina (São Paulo, Brazil), based on interviews, team discussions and group dynamics with resident physicians, postgraduate students and attending physicians. RESULTS: Implementation of the project allowed residents to build a story of differentiated care for their patients, thus facilitating dialog between them and making it possible to address taboo topics. Sequential care provided by the same resident led patients to feel that their doctor cared for them, with individuality, continuity and a sense of interest in their story. CONCLUSION: Presence of a psychologist in the outpatient routine enabled inclusion of subjective factors in the routine of medical consultations, thus broadening the notion of healthcare for patients with DSD, facilitating bonds and providing support for difficulties faced.
El teorema del Trabajo y la Energía en marcos de referencias rotacionales
Authors: Fernández D.M. , Carusela M.F. , Hasi C.D. El , Arriazu F. Lopez
Published: June 2016

En los libros de texto estándar de física universitaria, el Teorema del Trabajo y la Energía se presenta generalmente para sistemas de referencia inerciales, en los cuales está claro que la energía cinética se conserva cuando no hay trabajo neto de las fuerzas de interacción ¿Pero qué sucede cuando la energía y el trabajo se calculan en un marco de referencia no inercial? En general, en los textos básicos de física esta importante cuestión no es tratada. En este trabajo buscamos contribuir, en este aspecto, con una propuesta de actividades que permitan presentar y discutir este teorema parados como observadores en rotación relativa, haciendo hincapié explícitamente en las diferencias entre una y otra descripción. Esta propuesta tiene como objetivo la presentación gradual, mediante la discusión, de los conceptos a partir de ejemplos sencillos y prácticos, pero utilizando nociones básicas del formalismo vectorial.