bluuebunny/crossref_metadata_2025 huggingface dataset:
Theoretical Study of ClOO + NO Reaction: Mechanism and Kinetics
Authors: Wu Nan-Nan , Ou-Yang Shun-Li , Li Liang
Published: December 2017

Theoretical investigations are performed on mechanism and kinetics of the reaction of halogen peroxy radical ClOO with NO radical. The electronic structure information for both of the singlet and triplet potential energy surfaces (PESs) is obtained at the MP2/6-311 + G(2df) level of theory, and the single-point energies are refined by the CCSD(T)/6-311 + G(2df) level. The rate constants for various product channels of the reaction in the pressure range of 1-7600 Torr are predicted. The main results are as follows: On the singlet surface, the addition-elimination mechanism is the most important. First, the N atom of the NO radical can attack the O atom of the ClOO radical to form an energy-riched intermediate IM1 ClOONOtp (21.3 kcal/mol) barrierlessly, then IM1 could isomerizes to IM2 ClOONOcp (22.1 kcal/mol) via a low energy barrier. Both IM1 and IM2 can dissociate to the primary product P1 ClNO + 1O2 and the secondary product P2 ClO + NO2. On the triplet surface, the direct Cl-abstraction reaction is the most feasible pathway. The Cl-abstraction can take place via a van der Waals complex, 3IM1 ONClOO (4.1 kcal/mol), then it fragments readily to give P1’ ClNO + 3O2 with a small barrier. The kinetic calculations show that at low temperatures, the singlet bimolecular product P1 is the primary product, while at high temperatures, the triplet product P1’ becomes the primary one; only at high pressures and low temperatures, the unimolecular products IM1 and IM2 can be found with quite small yields. At experimentally measured temperature 213 K, ClNO is the primary product in the whole pressure range, which is consistent with the previous experiment. The present study may be useful for further experimental studies for the title reaction.
QNA-Based Prediction of Sites of Metabolism
Authors: Tarasova Olga , Rudik Anastassia , Dmitriev Alexander , Lagunin Alexey , Filimonov Dmitry , Poroikov Vladimir
Published: December 2017

Metabolism of xenobiotics (Greek xenos: exogenous substances) plays an essential role in the prediction of biological activity and testing for the subsequent research and development of new drug candidates. Integration of various methods and techniques using different computational and experimental approaches is one of the keys to a successful metabolism prediction. While multiple structure-based and ligand-based approaches to metabolism prediction exist, the most important problem arises at the first stage of metabolism prediction: detection of the sites of metabolism (SOMs). In this paper, we describe the application of Quantitative Neighborhoods of Atoms (QNA) descriptors for prediction of the SOMs using potential function method, as well as several different machine learning techniques: naïve Bayes, random forest classifier, multilayer perceptron with back propagation and convolutional neural networks, and deep neural networks.
Resveratrol Role in Autoimmune Disease—A Mini-Review
Authors: Oliveira Ana , Monteiro Valter , Navegantes-Lima Kely , Reis Jordano , Gomes Rafaelli , Rodrigues Dávila , Gaspar Silvia , Monteiro Marta
Published: December 2017

Autoimmune diseases are still considered to be pressing concerns due the fact that they are leaders in death and disability causes worldwide. Resveratrol is a polyphenol derived from a variety of foods and beverages, including red grapes and red wine. Anti-inflammatory, antioxidant, and antiaging properties of resveratrol have been reported, and in some animal and human studies this compound reduced and ameliorated the progression of autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and type 1 diabetes mellitus. Thus, this review aims to summarize and critically analyze the role of resveratrol in the modulation of several organ-specific or systemic autoimmune diseases.
Vitamin D: Moving Forward to Address Emerging Science
Authors: Taylor Christine , Sempos Christopher , Davis Cindy , Brannon Patsy
Published: December 2017

The science surrounding vitamin D presents both challenges and opportunities. Although many uncertainties are associated with the understandings concerning vitamin D, including its physiological function, the effects of excessive intake, and its role in health, it is at the same time a major interest in the research and health communities. The approach to evaluating and interpreting the available evidence about vitamin D should be founded on the quality of the data and on the conclusions that take into account the totality of the evidence. In addition, these activities can be used to identify critical data gaps and to help structure future research. The Office of Dietary Supplements (ODS) at the National Institutes of Health has as part of its mission the goal of supporting research and dialogues for topics with uncertain data, including vitamin D. This review considers vitamin D in the context of systematically addressing the uncertainty and in identifying research needs through the filter of the work of ODS. The focus includes the role of systematic reviews, activities that encompass considerations of the totality of the evidence, and collaborative activities to clarify unknowns or to fix methodological problems, as well as a case study using the relationship between cancer and vitamin D.
Effect of Cross-Linking on the Performances of Starch-Based Biopolymer as Gel Electrolyte for Dye-Sensitized Solar Cell Applications
Authors: Nagaraj Pavithra , Sasidharan Asija , David Velayutham , Sambandam Anandan
Published: December 2017

Dye-sensitized solar cells (DSSCs) have become a validated and economically credible competitor to the traditional solid-state junction photovoltaic devices. DSSCs based on biopolymer gel electrolyte systems offer the perspective of competitive conversion efficiencies with a very low-cost fabrication. In this paper, a new starch-based biopolymer gel electrolyte system is prepared by mixing lithium iodide and iodine with bare and citric acid cross-linked potato starches with glycerol as the plasticizing agent. The effect of the preparation methods on the starch cross-linking degree as well as the photoconversion efficiency of the resulting DSSC cells is carefully analyzed. Fourier transform spectroscopy, X-ray diffraction, and scanning electron microscopy were used to characterize the morphology and conformational changes of starch in the electrolytes. The conductivity of the biopolymer electrolytes was determined by electrochemical impedance spectroscopy. DSSC based on the starch-gel polymer electrolytes were characterized by photovoltaic measurements and electrochemical impedance spectroscopy. Results clearly show that the cross-linking increases the recombination resistance and open circuit voltage (VOC) of the DSSC, and thereby the photoconversion efficiency of the cell. In particular, electrolytes containing 1.4 g bare and cross-linked starches showed ionic conductivities of σ = 1.61, 0.59, 0.38, and 0.35 S cm−1, and the corresponding DSSCs showed efficiencies of 1.2, 1.4, 0.93, and 1.11%, respectively.
Isolation and Characterization of Serum Extracellular Vesicles (EVs) from Atlantic Salmon Infected with Piscirickettsia Salmonis
Authors: Lagos Leidy , Tandberg Julia , Kashulin-Bekkelund Alexander , Colquhoun Duncan , Sørum Henning , Winther-Larsen Hanne
Published: December 2017

Secretion of extracellular vesicles (EVs) is a common feature of both eukaryotic and prokaryotic cells. Isolated EVs have been shown to contain different types of molecules, including proteins and nucleic acids, and are reported to be key players in intercellular communication. Little is known, however, of EV secretion in fish, or the effect of infection on EV release and content. In the present study, EVs were isolated from the serum of healthy and Piscirickettsia salmonis infected Atlantic salmon in order to evaluate the effect of infection on EV secretion. P. salmonis is facultative intracellular bacterium that causes a systemic infection disease in farmed salmonids. EVs isolated from both infected and non-infected fish had an average diameter of 230–300 nm, as confirmed by transmission electron microscopy, nanoparticle tracking, and flow cytometry. Mass spectrometry identified 180 proteins in serum EVs from both groups of fish. Interestingly, 35 unique proteins were identified in serum EVs isolated from the fish infected with P. salmonis. These unique proteins included proteasomes subunits, granulins, and major histocompatibility class I and II. Our results suggest that EV release could be part of a mechanism in which host stimulatory molecules are released from infected cells to promote an immune response.
GPS and BeiDou Differential Code Bias Estimation Using Fengyun-3C Satellite Onboard GNSS Observations
Authors: Li Wenwen , Li Min , Shi Chuang , Fang Rongxin , Zhao Qile , Meng Xiangguang , Yang Guanglin , Bai Weihua
Published: December 2017

Differential code biases (DCBs) are important parameters in GNSS (Global Navigation Satellite System) applications such as positioning as well as ionosphere remote sensing. In comparison to the conventional approach, which utilizes ground-based observations and parameterizes global ionosphere maps together with DCBs, a method is presented for GPS and BeiDou system (BDS) satellite DCB estimation using onboard observations from the Chinese Fengyun-3C (FY3C) satellite. One month worth of GPS and BDS data during March 2015 was exploited and the GPS C1C-C2W and BDS C2I-C7I DCBs were explored. To improve DCB estimation precision, the dual frequency carrier phase measurements leveled by code measurements were used to form basic observation equation. Code multipath errors of the FY3C onboard GPS/BDS observations were assessed and modeled as grid maps, and their impact on DCB estimation was analyzed. By correcting code multipath errors, the stability of DCB estimates was improved by 5.0%, 3.1%, 16.2% and 13.6% for GPS, and BDS geosynchronous orbit satellites (GEOs), inclined geosynchronous satellite orbit satellites (IGSOs) and medium Earth orbit satellites (MEOs), respectively. The monthly stability of FY3C-based DCBs was at the order of 0.1 ns for GPS satellites, 0.2 ns for BDS GEOs and 0.1 ns for BDS IGSOs and MEOs. By comparison to the ground-based DCB products issued by other institutions, FY3C-based DCBs showed stability degradation for BDS C02 and C05 satellites, while, for other satellites, the stability reached a similar or even superior level. The estimated FY3C receiver DCB stability was at the order of 0.2 ns for both GPS and BDS. In addition to the DCB estimates, the obtained vertical total electron content above the FY3C satellite orbit was also investigated and its realism was examined in physical and numerical aspects.
Investigating the Influence of Variable Freshwater Ice Types on Passive and Active Microwave Observations
Authors: Gunn Grant , Duguay Claude , Derksen Chris , Clausi David , Toose Peter
Published: December 2017

Dual-polarized airborne passive microwave (PM) brightness temperatures (Tb) at 6.9 GHz H/V, 19 GHz H/V and 37 GHz H/V and spaceborne active microwave (AM) X-band (9.65 GHz VV, VH) backscatter (σ0) are observed coincident to in situ snow and lake-ice measurements collected over two lakes near Inuvik, Canada. Lake-ice thickness is found to be positively correlated with 19 GHz V emission (R = 0.67) and negatively with 19 GHz H emission (R = −0.79), indicating surface ice conditions influence microwave interaction. Lake ice types are delineated from TerraSAR-X synthetic aperture radar (SAR) images using the iterative region growing with semantics (IRGS) segmentation algorithm implemented in the MAGIC (MAp Guided Ice Classification) system. The spatial extent of derived ice type classes correspond well to in situ observations. The overall magnitude of emission at 19 GHz H and X-band VH σ0 increase with the scattering potential of associated ice types (grey/rafted ice). Transects of 6.9 GHz PM and 19 GHz PM exhibit positive relationships with VH σ0 over freshwater lake ice, with the greatest R coefficients at H-pol (R = 0.64, 0.46). Conversely, 6.9 GHz Tb and 19 GHz Tb exhibit negative R coefficients in regions of brackish water due to tubular bubble and brine inclusions in the ice. This study identifies congruency between PM and AM scattering mechanisms over lake ice for the purpose of identifying the influence of ice types on overall microwave interaction within the lake-ice system.
Determination of the Downwelling Diffuse Attenuation Coefficient of Lake Water with the Sentinel-3A OLCI
Authors: Shen Ming , Duan Hongtao , Cao Zhigang , Xue Kun , Loiselle Steven , Yesou Herve
Published: December 2017

The Ocean and Land Color Imager (OLCI) on the Sentinel-3A satellite, which was launched by the European Space Agency in 2016, is a new-generation water color sensor with a spatial resolution of 300 m and 21 bands in the range of 400–1020 nm. The OLCI is important to the expansion of remote sensing monitoring of inland waters using water color satellite data. In this study, we developed a dual band ratio algorithm for the downwelling diffuse attenuation coefficient at 490 nm (Kd(490)) for the waters of Lake Taihu, a large shallow lake in China, based on data measured during seven surveys conducted between 2008 and 2017 in combination with Sentinel-3A-OLCI data. The results show that: (1) Compared to the available Kd(490) estimation algorithms, the dual band ratio (681 nm/560 nm and 754 nm/560 nm) algorithm developed in this study had a higher estimation accuracy (N = 26, coefficient of determination (R2) = 0.81, root-mean-square error (RMSE) = 0.99 m−1 and mean absolute percentage error (MAPE) = 19.55%) and validation accuracy (N = 14, R2 = 0.83, RMSE = 1.06 m−1 and MAPE = 27.30%), making it more suitable for turbid inland waters; (2) A comparison of the OLCI Kd(490) product and a similar Moderate Resolution Imaging Spectroradiometer (MODIS) product reveals a high consistency between the OLCI and MODIS products in terms of the spatial distribution of Kd(490). However, the OLCI product has a smoother spatial distribution and finer textural characteristics than the MODIS product and contains notably higher-quality data; (3) The Kd(490) values for Lake Taihu exhibit notable spatial and temporal variations. Kd(490) is higher in seasons with relatively high wind speeds and in open waters that are prone to wind- and wave-induced sediment resuspension. Finally, the Sentinel-3A-OLCI has a higher spatial resolution and is equipped with a relatively wide dynamic range of spectral bands suitable for inland waters. The Sentinel-3B satellite will be launched soon and, together with the Sentinel-3A satellite, will form a two-satellite network with the ability to make observations twice every three days. This satellite network will have a wider range of application and play an important role in the monitoring of inland waters with complex optical properties.
On-Orbit Radiometric Calibration for a Space-Borne Multi-Camera Mosaic Imaging Sensor
Authors: Xie Yong , Han Jie , Gu Xingfa , Liu Qiyue
Published: December 2017

As the core and foundational technology, on-orbit radiometric calibration of a space-borne sensor is of great importance for quantitative remote sensing applications. As for the space-borne multi-camera mosaic imaging sensor, however, the currently available on-orbit radiometric calibration method cannot carry out the integrated processing of on-orbit absolute radiometric calibration and relative radiometric correction simultaneously between cameras, influencing the accuracy of quantitative applications. Therefore, taking the GaoFen-1 (GF-1) wide-field-of-view (WFV) sensor as an example in this research, an innovative on-orbit radiometric calibration method is proposed to overcome this bottleneck. Firstly, according to the principle of the cross-calibration approach, we retrieve valid MODIS and GF-1 WFV image pairs over the Dunhuang radiometric calibration sites (DRCS) in China by using a set of criteria and extract the radiometric control points (RCPs) connecting in both images. Secondly, the DEM-aided block adjustment of the rational function model is applied to eliminate the geometrical misalignment of GF-1 WFV images at the same orbit. Then, the average digital numbers of spectral and spatial homogeneous surfaces are calculated and chosen as the radiometric tie points (RTPs) extracted from the overlapping region of the adjacent WFV cameras. Thirdly, the radiometric block adjustment (RBA) algorithm is introduced into on-orbit radiometric calibration of the space-borne multi-camera mosaic imaging sensor. Finally, the radiometric calibration coefficients are solved by the least square method. The validation results indicate that our proposed method can acquire high absolute radiometric calibration accuracy and achieve relative radiometric correction between cameras. Compared with the results using the cross-calibration method to calibrate each WFV camera independently, the advantages of RBA are presented. In addition, the uncertainties caused by RCPs’ distribution are discussed, which is beneficial to further optimize the calibration program.
Efficient Background Segmentation and Seed Point Generation for a Single-Shot Stereo System
Authors: Yang Xiao , Chen Xiaobo , Xi Juntong
Published: December 2017

Single-shot stereo 3D shape measurement is becoming more popular due to its advantages of noise robustness and short acquisition period. One of the key problems is stereo matching, which is related to the efficiency of background segmentation and seed point generation, etc. In this paper, a more efficient and automated matching algorithm based on digital image correlation (DIC) is proposed. The standard deviation of image gradients and an adaptive threshold are employed to segment the background. Scale-invariant feature transform (SIFT)-based feature matching and two-dimensional triangulation are combined to estimate accurate initial parameters for seed point generation. The efficiency of background segmentation and seed point generation, as well as the measuring precision, are evaluated by experimental simulation and real tests. Experimental results show that the average segmentation time for an image with a resolution of 1280 × 960 pixels is 240 milliseconds. The efficiency of seed point generation is verified to be high with different convergence criteria.
A Pseudorange Measurement Scheme Based on Snapshot for Base Station Positioning Receivers
Authors: Mo Jun , Deng Zhongliang , Jia Buyun , Bian Xinmei
Published: December 2017

Digital multimedia broadcasting signal is promised to be a wireless positioning signal. This paper mainly studies a multimedia broadcasting technology, named China mobile multimedia broadcasting (CMMB), in the context of positioning. Theoretical and practical analysis on the CMMB signal suggests that the existing CMMB signal does not have the meter positioning capability. So, the CMMB system has been modified to achieve meter positioning capability by multiplexing the CMMB signal and pseudo codes in the same frequency band. The time difference of arrival (TDOA) estimation method is used in base station positioning receivers. Due to the influence of a complex fading channel and the limited bandwidth of receivers, the regular tracking method based on pseudo code ranging is difficult to provide continuous and accurate TDOA estimations. A pseudorange measurement scheme based on snapshot is proposed to solve the problem. This algorithm extracts the TDOA estimation from the stored signal fragments, and utilizes the Taylor expansion of the autocorrelation function to improve the TDOA estimation accuracy. Monte Carlo simulations and real data tests show that the proposed algorithm can significantly reduce the TDOA estimation error for base station positioning receivers, and then the modified CMMB system achieves meter positioning accuracy.
A Direct Bicarbonate Detection Method Based on a Near-Concentric Cavity-Enhanced Raman Spectroscopy System
Authors: Yang Dewang , Guo Jinjia , Liu Chunhao , Liu Qingsheng , Zheng Ronger
Published: December 2017

Raman spectroscopy has great potential as a tool in a variety of hydrothermal science applications. However, its low sensitivity has limited its use in common sea areas. In this paper, we develop a near-concentric cavity-enhanced Raman spectroscopy system to directly detect bicarbonate in seawater for the first time. With the aid of this near-concentric cavity-enhanced Raman spectroscopy system, a significant enhancement in HCO3− detection has been achieved. The obtained limit of detection (LOD) is determined to be 0.37 mmol/L—much lower than the typical concentration of HCO3− in seawater. By introducing a specially developed data processing scheme, the weak HCO3− signal is extracted from the strong sulfate signal background, hence a quantitative analysis with R2 of 0.951 is made possible. Based on the spectra taken from deep sea seawater sampling, the concentration of HCO3− has been determined to be 1.91 mmol/L, with a relative error of 2.1% from the reported value (1.95 mmol/L) of seawater in the ocean. It is expected that the near-concentric cavity-enhanced Raman spectroscopy system could be developed and used for in-situ ocean observation in the near future.
Marked Object Recognition Multitouch Screen Printed Touchpad for Interactive Applications
Authors: Nunes Jivago , Castro Nelson , Gonçalves Sergio , Pereira Nélson , Correia Vitor , Lanceros-Mendez Senentxu
Published: December 2017

The market for interactive platforms is rapidly growing, and touchscreens have been incorporated in an increasing number of devices. Thus, the area of smart objects and devices is strongly increasing by adding interactive touch and multimedia content, leading to new uses and capabilities. In this work, a flexible screen printed sensor matrix is fabricated based on silver ink in a polyethylene terephthalate (PET) substrate. Diamond shaped capacitive electrodes coupled with conventional capacitive reading electronics enables fabrication of a highly functional capacitive touchpad, and also allows for the identification of marked objects. For the latter, the capacitive signatures are identified by intersecting points and distances between them. Thus, this work demonstrates the applicability of a low cost method using royalty-free geometries and technologies for the development of flexible multitouch touchpads for the implementation of interactive and object recognition applications.
PCA Based Stress Monitoring of Cylindrical Specimens Using PZTs and Guided Waves
Authors: Quiroga Jabid , Mujica Luis , Villamizar Rodolfo , Ruiz Magda , Camacho Jhonatan
Published: December 2017

Since mechanical stress in structures affects issues such as strength, expected operational life and dimensional stability, a continuous stress monitoring scheme is necessary for a complete integrity assessment. Consequently, this paper proposes a stress monitoring scheme for cylindrical specimens, which are widely used in structures such as pipelines, wind turbines or bridges. The approach consists of tracking guided wave variations due to load changes, by comparing wave statistical patterns via Principal Component Analysis (PCA). Each load scenario is projected to the PCA space by means of a baseline model and represented using the Q-statistical indices. Experimental validation of the proposed methodology is conducted on two specimens: (i) a 12.7 mm ( 1 / 2 ″ ) diameter, 0.4 m length, AISI 1020 steel rod, and (ii) a 25.4 mm ( 1 ″ ) diameter, 6m length, schedule 40, A-106, hollow cylinder. Specimen 1 was subjected to axial loads, meanwhile specimen 2 to flexion. In both cases, simultaneous longitudinal and flexural guided waves were generated via piezoelectric devices (PZTs) in a pitch-catch configuration. Experimental results show the feasibility of the approach and its potential use as in-situ continuous stress monitoring application.
Triple Recycling Channel Strategies for Remanufacturing of Construction Machinery in a Retailer-Dominated Closed-Loop Supply Chain
Authors: Huang Min , Yi Pengxing , Shi TieLin
Published: December 2017

Firms engaged in remanufacturing activities generally adopt more than one recycling channel to collect more used products and gain more profits. This paper explores the optimal strategies for a retailer-dominated closed-loop supply chain (CLSC) with a triple recycling channel in the construction machinery remanufacturing context. In this special system, the retailer is the leader and authorized by the original equipment manufacturer (OEM) to remanufacture. Moreover, the OEM, the retailer, and the secondary market all take part in the used products collection activities. Considering the differentiation of the OEM, the retailer, and the secondary market in collecting the used construction machinery, a mathematical model of the CLSC system based on reasonable assumptions is built, the closed-form optimal pricing decisions are derived, and the optimal collection efforts allocation strategies are explored within the framework of the game theory. In addition, the impacts of the reverse logistics cost coefficient, the competing coefficient, and the buy-back price coefficient on the supply chain performance are elaborately analyzed. These achievements provide decision makers with managerial insights and offer efficient guidelines for the construction machinery remanufacturing firms to solve similar puzzles.
Studies on Pounding Response Considering Structure-Soil-Structure Interaction under Seismic Loads
Authors: Li Peizhen , Liu Shutong , Lu Zheng
Published: December 2017

Pounding phenomena considering structure–soil–structure interaction (SSSI) under seismic loads are investigated in this paper. Based on a practical engineering project, this work presents a three-dimensional finite element numerical simulation method using ANSYS software. According to Chinese design code, the models of adjacent shear wall structures on Shanghai soft soil with the rigid foundation, box foundation and pile foundation are built respectively. In the simulation, the Davidenkov model of the soil skeleton curve is assumed for soil behavior, and the contact elements with Kelvin model are adopted to simulate pounding phenomena between adjacent structures. Finally, the dynamic responses of adjacent structures considering the pounding and SSSI effects are analyzed. The results show that pounding phenomena may occur, indicating that the seismic separation requirement for adjacent buildings of Chinese design code may not be enough to avoid pounding effect. Pounding and SSSI effects worsen the adjacent buildings’ conditions because their acceleration and shear responses are amplified after pounding considering SSSI. These results are significant for studying the effect of pounding and SSSI phenomena on seismic responses of structures and national sustainable development, especially in earthquake prevention and disaster reduction.
A Model for Shovel Capital Cost Estimation, Using a Hybrid Model of Multivariate Regression and Neural Networks
Authors: Yazdani-Chamzini Abdolreza , Zavadskas Edmundas , Antucheviciene Jurgita , Bausys Romualdas
Published: December 2017

Cost estimation is an essential issue in feasibility studies in civil engineering. Many different methods can be applied to modelling costs. These methods can be divided into several main groups: (1) artificial intelligence, (2) statistical methods, and (3) analytical methods. In this paper, the multivariate regression (MVR) method, which is one of the most popular linear models, and the artificial neural network (ANN) method, which is widely applied to solving different prediction problems with a high degree of accuracy, have been combined to provide a cost estimate model for a shovel machine. This hybrid methodology is proposed, taking the advantages of MVR and ANN models in linear and nonlinear modelling, respectively. In the proposed model, the unique advantages of the MVR model in linear modelling are used first to recognize the existing linear structure in data, and, then, the ANN for determining nonlinear patterns in preprocessed data is applied. The results with three indices indicate that the proposed model is efficient and capable of increasing the prediction accuracy.
Continuity of Fuzzified Functions Using the Generalized Extension Principle
Authors: Wu Hsien-Chung
Published: December 2017

To fuzzify the crisp functions, the extension principle has been widely used for performing this fuzzification. The purpose of this paper is to investigate the continuity of fuzzified function using the more generalized extension principle. The Hausdorff metric will be invoked to study the continuity of fuzzified function. We also apply the principle of continuity of fuzzified function to the fuzzy topological vector space.
Characterization of the EBV-Induced Persistent DNA Damage Response
Authors: Hafez Amy , Luftig Micah
Published: December 2017

Epstein-Barr virus (EBV) is an oncogenic herpesvirus that is ubiquitous in the human population. Early after EBV infection in vitro, primary human B cells undergo a transient period of hyper-proliferation, which results in replicative stress and DNA damage, activation of the DNA damage response (DDR) pathway and, ultimately, senescence. In this study, we investigated DDR-mediated senescence in early arrested EBV-infected B cells and characterized the establishment of persistent DNA damage foci. We found that arrested EBV-infected B cells exhibited an increase in promyelocytic leukemia nuclear bodies (PML NBs), which predominantly localized to markers of DNA damage, as well as telomeric DNA. Furthermore, arrested EBV-infected B cells exhibited an increase in the presence of telomere dysfunction-induced foci. Importantly, we found that increasing human telomerase reverse transcriptase (hTERT) expression with danazol, a drug used to treat telomere diseases, permitted early EBV-infected B cells to overcome cellular senescence and enhanced transformation. Finally, we report that EBV-infected B cells undergoing hyper-proliferation are more sensitive than lymphoblastoid cell lines (LCLs) to inhibition of Bloom syndrome-associated helicase, which facilitates telomere replication. Together, our results describe the composition of persistent DNA damage foci in the early stages of EBV infection and define key regulators of this barrier to long-term outgrowth.
The Interplay between Natural Killer Cells and Human Herpesvirus-6
Authors: Eliassen Eva , Di Luca Dario , Rizzo Roberta , Barao Isabel
Published: December 2017

Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Natural killer (NK) cells are lymphocytes that, along with neutrophils and monocytes/macrophages, participate in the critical innate immune response during viral infections, but can also mediate the antigen-specific memory responses generally associated with adaptive immunity. NK cells compose the first barrier that viruses must break through to continue replication and dissemination, and a weak NK cell response may predispose an individual to chronic viral infections. Both HHV-6A and HHV-6B can interfere with NK cell-mediated anti-viral responses but the mechanisms by which each of these viruses affect NK cell activity differs. In this review, we will explore the nuanced relationships between the two viruses and NK cells, discussing, in addition, relevant disease associations.
Chikungunya Virus: Pathophysiology, Mechanism, and Modeling
Authors: Ganesan Vaishnavi , Duan Bin , Reid St
Published: December 2017

Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, is recurring in epidemic waves. In the past decade and a half, the disease has resurged in several countries around the globe, with outbreaks becoming increasingly severe. Though CHIKV was first isolated in 1952, there remain significant gaps in knowledge of CHIKV biology, pathogenesis, transmission, and mechanism. Diagnosis is largely simplified and based on symptoms, while treatment is supportive rather than curative. Here we present an overview of the disease, the challenges that lie ahead for future research, and what directions current studies are headed towards, with emphasis on improvement of current animal models and potential use of 3D models.
Water Security in Times of Climate Change and Intractability: Reconciling Conflict by Transforming Security Concerns into Equity Concerns
Authors: Powell Neil , Kløcker Larsen Rasmus , De Bruin Annemarieke , Powell Stina , Elrick-Barr Carmen
Published: December 2017

This paper considers how to achieve equitable water governance and the flow-on effects it has in terms of supporting sustainable development, drawing on case studies from the international climate change adaptation and governance project (CADWAGO). Water governance, like many other global issues, is becoming increasingly intractable (wicked) with climate change and is, by the international community, being linked to instances of threats to human security, the war in the Sudanese Darfur and more recently the acts of terrorism perpetuated by ISIS. In this paper, we ask the question: how can situations characterized by water controversy (exacerbated by the uncertainties posed by climate change) be reconciled? The main argument is based on a critique of the way the water security discourse appropriates expert (normal) claims about human-biophysical relationships. When water challenges become increasingly securitized by the climate change discourse it becomes permissible to enact processes that legitimately transgress normative positions through post-normal actions. In contrast, the water equity discourse offers an alternative reading of wicked and post-normal water governance situations. We contend that by infusing norm critical considerations into the process of securitization, new sub-national constellations of agents will be empowered to enact changes; thereby bypassing vicious cycles of power brokering that characterize contemporary processes intended to address controversies.
Hydraulic Parameter Generation Technique Using a Discrete Fracture Network with Bedrock Heterogeneity in Korea
Authors: Cheong Jae-Yeol , Hamm Se-Yeong , Lim Doo-Hyun , Kim Soo-Gin
Published: December 2017

In instances of damage to engineered barriers containing nuclear waste material, surrounding bedrock is a natural barrier that retards radionuclide movement by way of adsorption and delay due to groundwater flow through highly tortuous fractured rock pathways. At the Gyeongju nuclear waste disposal site, groundwater mainly flows through granitic and sedimentary rock fractures. Therefore, to understand the nuclide migration path, it is necessary to understand discrete fracture networks based on heterogeneous fracture orientations, densities, and size characteristics. In this study, detailed heterogeneous fracture distribution, including the density and orientation of the fractures, was considered for a region that has undergone long periods of change from various geological activities at and around the Gyeongju site. A site-scale discrete fracture network (DFN) model was constructed taking into account: (i) regional fracture heterogeneity constrained by a multiple linear regression analysis of fracture intensity on faults and electrical resistivity; and (ii) the connectivity of conductive fractures having fracture hydraulic parameters, using transient flow simulation. Geometric and hydraulic heterogeneity of the DFN was upscaled into equivalent porous media for flow and transport simulation for a large-scale model.
Robust nanobubble and nanodroplet segmentation in atomic force microscope images using the spherical Hough transform
Authors: Wang Yuliang , Lu Tongda , Li Xiaolai , Ren Shuai , Bi Shusheng
Published: December 2017

Interfacial nanobubbles (NBs) and nanodroplets (NDs) have been attracting increasing attention due to their potential for numerous applications. As a result, the automated segmentation and morphological characterization of NBs and NDs in atomic force microscope (AFM) images is highly awaited. The current segmentation methods suffer from the uneven background in AFM images due to thermal drift and hysteresis of AFM scanners. In this study, a two-step approach was proposed to segment NBs and NDs in AFM images in an automated manner. The spherical Hough transform (SHT) and a boundary optimization operation were combined to achieve robust segmentation. The SHT was first used to preliminarily detect NBs and NDs. After that, the so-called contour expansion operation was applied to achieve optimized boundaries. The principle and the detailed procedure of the proposed method were presented, followed by the demonstration of the automated segmentation and morphological characterization. The result shows that the proposed method gives an improved segmentation result compared with the thresholding and circle Hough transform method. Moreover, the proposed method shows strong robustness of segmentation in AFM images with an uneven background.
Evaluation of the Subjective Effect of Middle Ear Implantation in Hearing-Impaired Patients with Severe External Otitis
Authors: Snik Ad F.M. , van Duijnhoven Noortje T.L. , Mulder Jef J.S. , Cremers Cor W.R.J.
Published: December 2017

The subjective benefit of middle ear implantation was studied in a group of 23 hearing-impaired patients who could not use conventional hearing aids owing to severe chronic external otitis. Changes in hearing disability (Abbreviated Profile of Hearing Aid Benefit [APHAB]) and changes
in quality of life (Glasgow Benefit Inventory [GBI]) were determined. Mean benefit value on the APHAB for the subscale Ease of Communication was close to the mean reference value for conventional hearing aids. For the subscales Reverberation and Background Noise, a poorer result was found.
Individual analysis of the APHAB scores showed significant benefit in 12 out of the 23 patients. According to the GBI, 16 out of 17 patients reported that middle ear implantation had made a positive impact on their quality of life. It is concluded that middle ear implantation has a positive
effect on hearing difficulties and quality of life in hearing-impaired subjects who cannot use conventional devices. The APHAB outcomes were not better than those reported for conventional devices. Se estudió el beneficio subjetivo de la implantación del oído medio en
un grupo de 23 pacientes hipoacúsicos que no podían utilizar auxiliares auditivos convencionales debido a una otitis externa crónica severa. Se determinaron los cambios en discapacidad auditiva (Perfil Abreviado del Beneficio del Auxiliar Auditivo [APHAB]) y los cambios
en la calidad de vida (Inventario Glasgow de Beneficio [GBI]). El valor medio de beneficio en el APHAB para la sub-escala Facilidad de Comunicación fue cercano al valor medio de referencia para los auxiliares auditivos convencionales. Para las sub-escalas de Reverberación y Ruido
de Fondo, se encontró un resultado más pobre. El análisis individual de los puntajes APHAB mostró un beneficio significativo en 12 de los 23 pacientes. De acuerdo con el GBI, 16 de los 17 pacientes reportaron que la implantación del oído medio había
tenido un impacto positivo en la calidad de sus vidas. Se concluye que la implantación del oído medio tiene un efecto positivo sobre las dificultades de comunicación y sobre la calidad de vida en sujetos hipoacúsicos que no pueden utilizar dispositivos convencionales.
Los resultados del APHAB no fueron mejores que aquellos reportados con dispositivos convencionales.
Constraints on the Obliquities of Kepler Planet-hosting Stars
Authors: Winn Joshua N. , Petigura Erik A. , Morton Timothy D. , Weiss Lauren M. , Dai Fei , Schlaufman Kevin C. , Howard Andrew W. , Isaacson Howard , Marcy Geoffrey W. , Justesen Anders Bo , Albrecht Simon
Published: December 2017

Stars with hot Jupiters have obliquities ranging from 0° to 180°, but relatively little is known about the obliquities of stars with smaller planets. Using data from the California-Kepler Survey, we investigate the obliquities of stars with planets spanning a wide range of sizes, most of which are smaller than Neptune. First, we identify 156 planet hosts for which measurements of the projected rotation velocity (

) and rotation period are both available. By combining estimates of v and

, we find nearly all the stars to be compatible with high inclination, and hence, low obliquity (≲20°). Second, we focus on a sample of 159 hot stars (

K) for which

is available but not necessarily the rotation period. We find six stars for which

is anomalously low, an indicator of high obliquity. Half of these have hot Jupiters, even though only 3% of the stars that were searched have hot Jupiters. We also compare the

distribution of the hot stars with planets to that of 83 control stars selected without prior knowledge of planets. The mean

of the control stars is lower than that of the planet hosts by a factor of approximately

, as one would expect if the planet hosts have low obliquities. All these findings suggest that the Kepler planet-hosting stars generally have low obliquities, with the exception of hot stars with hot Jupiters.
New Orbits for 18 Binaries
Authors: Cvetković Z. , Pavlović R.
Published: December 2017

Orbital elements of 18 visual binaries are computed using the measurements collected in the Fourth Catalog of Interferometric Measurements of Binary Stars; 15 orbits are determined for the first time and three orbits are revised. Eleven of the binaries, denoted as HDS, were discovered during the Hipparcos mission. The remaining binaries were discovered a few years earlier or later than 1991. All studied pairs are close, and all measured separations are less than

. The shortest orbital period is 10 years and the longest orbital period is 127 years. Dynamical parallaxes and total masses of systems are derived from the orbital elements. We also give absolute magnitudes, spectral types, and

residuals in θ and ρ.
Estimating Spectra from Photometry
Authors: Kalmbach J. Bryce , Connolly Andrew J.
Published: December 2017

Measuring the physical properties of galaxies such as redshift frequently requires the use of spectral energy distributions (SEDs). SED template sets are, however, often small in number and cover limited portions of photometric color space. Here we present a new method to estimate SEDs as a function of color from a small training set of template SEDs. We first cover the mathematical background behind the technique before demonstrating our ability to reconstruct spectra based upon colors and then compare our results to other common interpolation and extrapolation methods. When the photometric filters and spectra overlap, we show that the error in the estimated spectra is reduced by more than 65% compared to the more commonly used techniques. We also show an expansion of the method to wavelengths beyond the range of the photometric filters. Finally, we demonstrate the usefulness of our technique by generating 50 additional SED templates from an original set of 10 and by applying the new set to photometric redshift estimation. We are able to reduce the photometric redshifts standard deviation by at least 22.0% and the outlier rejected bias by over 86.2% compared to original set for z ≤ 3.
Hubble Space Telescope Imaging of the Active Dwarf Galaxy RGG 118
Authors: Baldassare Vivienne F. , Reines Amy E. , Gallo Elena , Greene Jenny E.
Published: December 2017

RGG 118 (SDSS 1523+1145) is a nearby (z = 0.0243), dwarf disk galaxy (

) that is found to host an active ∼50,000 solar mass black hole at its core. RGG 118 is one of a growing collective sample of dwarf galaxies known to contain active galactic nuclei (AGNs)—a group that, until recently, contained only a handful of objects. Here, we report on new Hubble Space Telescope Wide Field Camera 3 UVIS and IR imaging of RGG 118, with the main goal of analyzing its structure. Using 2D parametric modeling, we find that the morphology of RGG 118 is best described by an outer spiral disk, an inner component consistent with a pseudobulge, and a central point-spread function (PSF). The luminosity of the PSF is consistent with the central point source that is being dominated by the AGN. We measure the luminosity and the mass of the “pseudobulge” and confirm that the central black hole in RGG 118 is under-massive, with respect to the

and

relations. This result is consistent with a picture in which black holes in disk-dominated galaxies grow primarily through secular processes.
The Behavior of Selected Diffuse Interstellar Bands with Molecular Fraction in Diffuse Atomic and Molecular Clouds
Authors: Fan Haoyu , Welty Daniel E. , York Donald G. , Sonnentrucker Paule , Dahlstrom Julie A. , Baskes Noah , Friedman Scott D. , Hobbs Lewis M. , Jiang Zihao , Rachford Brian , Snow Theodore P. , Sherman Reid , Zhao Gang
Published: December 2017

We study the behavior of eight diffuse interstellar bands (DIBs) in different interstellar environments, as characterized by the fraction of hydrogen in molecular form (f
H2), with comparisons to the corresponding behavior of various known atomic and molecular species. The equivalent widths of the five “normal” DIBs (λλ5780.5, 5797.1, 6196.0, 6283.8, and 6613.6), normalized to E

B–V
, show a “lambda-shaped” behavior: they increase at low f
H2, peak at f
H2 ∼ 0.3, and then decrease. The similarly normalized column densities of Ca, Ca+, Ti+, and CH+ also decline for f
H2 > 0.3. In contrast, the normalized column densities of Na, K, CH, CN, and CO increase monotonically with f
H2, and the trends exhibited by the three C2 DIBs (λλ4726.8, 4963.9, and 4984.8) lie between those two general behaviors. These trends with f
H2 are accompanied by cosmic scatter, the dispersion at any given f
H2 being significantly larger than the individual errors of measurement. The lambda-shaped trends suggest the balance between creation and destruction of the DIB carriers differs dramatically between diffuse atomic and diffuse molecular clouds; additional processes aside from ionization and shielding are needed to explain those observed trends. Except for several special cases, the highest W

λ
(5780)/W

λ
(5797) ratios, characterizing the so-called “sigma-zeta effect,” occur only at f
H2 < 0.2. We propose a sequence of DIBs based on trends in their pair-wise strength ratios with increasing f
H2. In order of increasing environmental density, we find the λ6283.8 and λ5780.5 DIBs, the λ6196.0 DIB, the λ6613.6 DIB, the λ5797.1 DIB, and the C2 DIBs.
A Jet Source of Event Horizon Telescope Correlated Flux in M87
Authors: Punsly Brian
Published: December 2017

Event Horizon Telescope (EHT) observations at 230 GHz are combined with Very Long Baseline Interferometry (VLBI) observations at 86 GHz and high-resolution Hubble Space Telescope optical observations in order to constrain the broadband spectrum of the emission from the base of the jet in M87. The recent VLBI observations of Hada et al. provide much stricter limits on the 86 GHz luminosity and component acceleration in the jet base than were available to previous modelers. They reveal an almost hollow jet on sub-mas scales. Thus, tubular models of the jet base emanating from the innermost accretion disk are considered within the region responsible for the EHT correlated flux. There is substantial synchrotron self-absorbed opacity at 86 GHz. A parametric analysis indicates that the jet dimensions and power depend strongly on the 86 GHz flux density and the black hole spin, but depend weakly on other parameters, such as jet speed, 230 GHz flux density, and optical flux. The entire power budget of the M87 jet,

, can be accommodated by the tubular jet. No invisible, powerful spine is required. Even though this analysis never employs the resolution of the EHT, the spectral shape implies a dimension transverse to the jet direction of 12–21

(

) for

(

), where M is the mass and a is the angular momentum per unit mass of the central black hole.