bluuebunny/crossref_metadata_2025 huggingface dataset:
Renal artery stenosis of atherosclerotic etiology – the single kidney surgical recurrence 12 years after nephrectomy
Authors:   Departamentul I de Medicină Internă şi Nefrologie, Facultatea de Medicină,  Spitalul Universitar de Urgenţă, Bucureşti, Tănăsescu Maria Daniela ,   Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Pălămar Marcel ,   Centrul de Dializă, Spitalul Judeţean de Urgenţă, Deva, Comşa Mihai Ovidiu ,   Departamentul I de Medicină Internă şi Nefrologie, Facultatea de Medicină,  Spitalul Universitar de Urgenţă, Bucureşti; Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Mincă Alexandru ,   Departamentul I de Medicină Internă şi Nefrologie, Facultatea de Medicină,  Spitalul Universitar de Urgenţă, Bucureşti; Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Diaconescu Alexandru Cristian ,   Secţia Nefrologie/Dializă, Spitalul Universitar de Urgenţă, Bucureşti, Frântu Mădălina ,   Secţia Nefrologie, Spitalul Universitar de Urgenţă, Bucureşti, Vicol Cezara ,   Secţia Nefrologie, Spitalul Universitar de Urgenţă, Bucureşti, Boţocan Alexandru Ciprian ,   Clinica de Nefrologie, Spitalul Clinic de Urgenţă „Sfântul Ioan“, Bucureşti, Limbău Alexandra ,   Departamentul de Dermatologie, Facultatea de Medicină, Spitalul Clinic „Dr. Victor Babeş“, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Ionescu Dorin ,   Departamentul I de Medicină Internă şi Nefrologie, Facultatea de Medicină,  Spitalul Universitar de Urgenţă, Bucureşti; Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: September 2021

Objectives. Renal artery stenosis, as main cause of renovascular secondary hypertension, is mainly caused by atherosclerosis of large vessels and is clinically characterized by resistant or malignant hypertension, impacting the kidney function to various degrees. The present article brings into attention the case of a patient which developed renal artery stenosis on the left kidney, the same condition occurring 12 years later on the right kidney. Material and method. Our patient was initially diagnosed at the age of 48 with complete occlusion of the left renal artery, for which left nephrectomy was performed, while the right artery was normal. Twelve years later she presents with renal artery stenosis on the right kidney, which is treat by stent-angioplasty. Results. After surgery, the patient’s evolution was positive, with amelioration of the laboratory values, in parallel to the arterial blood pressure. Discussions. The probability that, in the moment of diagnosis of renal artery stenosis with progressive evolution to occlusion caused by atherosclerosis, the other artery would be normal, both seen by ultrasonography and angiography, while years later to develop stenosis, is minimal. Up to present, the literature holds little evidence of such similar cases. Conclusions. In the particular case of patients that were diagnosed with severe renal artery stenosis of atherosclerotic origin and had only one of the arteries affected, it is necessary to keep a permanent monitoring, justified by the risk of development of the same pathology to the other artery
Observations and reflections based on the experience of elderly caregiving
Authors:   Centrul medico-social „Sf. Andrei“, Bucureşti, Constantin Bogdan , Ceucă Mihaela ,   Spitalul de Geriatrie „Sf. Luca“, Bucureşti
Published: September 2021

Studies dedicated to the process of frailty in geriatrics and gerontology, and also the attempts to individualize a new geriatric syndrome it was a concern in the last years. The authors of this paper, having an unique experience in caring for frail elderly (one of us directly cared frail elderly patients for more than thirty years) have accumulated many observation – clinical, laboratory, nursing and prevention – opportunity for reflection based on author’s opinions. The most important reflection expresses primarily the difficulty to mark off such a syndrome, to have a consensus, which is a condition to integrate a new entity. The rich semiology of elderly patients, the (multi) functional decline inspired over the years many researchers who elaborated nosological descriptions overlapped, more or less to the frailty syndrome. UNO proposed from several years a classification of elderly in the “active elderly” and “frail elderly”. Others described the psycho-motor regression has described as “elder’s multiple vulnerabilities syndrome”. Moreover, frailty is not a specific status of the elderly, but it could be interpreted rather as a “state” than a syndrome, such as bedridden condition, terminal condition, state of dependence, severe stages of dementias and so on. Despite the difficulties of defining the concept of frailty brings some benefit concerning the understanding of the specificity of elderly patient, the holistic approach of his problems, not least provides tools to indicate the need of preventive measures, with good effects on the longevity and the quality of life.
Present data in the diagnosis and treatment of coeliac disease (Part I)
Authors:   Spitalul Universitar de Urgenţă, Bucureşti, Olteanu Dan , Diaconescu Alexandru ,   Spitalul Universitar de Urgenţă, Bucureşti, Voiosu Radu ,   Spitalul Clinic „Colentina“, Bucureşti, Voiosu Andrei ,   Spitalul Clinic „Colentina“, Bucureşti, Olariu Cristina ,   Institutul Naţional de Boli Infecţioase „Matei Balş“, Bucureşti
Published: September 2021

Coeliac disease incidence raised during the last 50 years and represents a concern by diagnostic problems and costs. The recent data regarding etiology, pathogeny, comparative diagnostic value of serology and small intestinal biopsy are summarised. New data about refractory celiac disease to gluten free diet and therapeutic perspectives are also presented (glutenases, larazotide acetate, genetic alteration of cereals, tissulary transglutaminase inhibitors etc).
Functional Dyspepsia – Part I
Authors:   Spitalul Universitar de Urgenţă, Bucureşti, Olteanu Dan , Şchiopu Oana ,   Spitalul Universitar de Urgenţă, Bucureşti
Published: September 2021

The present pathophysiological features and therapeutic methods are presented. A treatment and diagnostic algorithm is offered. New therapies in refractory functional dyspepsia are presented.
BARIATRIC SURGERY AND OSTEOPOROSIS
Authors:   “C.I. Parhon” National Institute of Endocrinology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Carsote Mara , Petrescu Razvan ,   “Medlife”, Brasov, Nica Adriana Elena ,   University Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Ghemigian Adina ,   “C.I. Parhon” National Institute of Endocrinology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Paduraru Dan Nicolae ,   University Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Valea Ana ,   Clinical County Hospital, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca
Published: September 2021

Introduction. Bariatric surgery, regardless the type of approach, has aggressively extended nowadays. The procedure saves lives due to substantial improvement of severe cardio-metabolic co-morbidities, but the influence of nutritional status might not be completely harmless including bone and muscle changes. Our purpose is to introduce data regarding skeleton after bariatric surgery. This is a narrative mini-review including papers from PubMed. A selection of 33 papers has been done. General data. Longitudinal better than cross-sectional studies confirmed an annual rate of losing bone mineral density at lumbar and femoral neck of 3-10% starting with first year after surgery and continuing within the third year; low vitamin D and calcium absorption with associated secondary hyperparathyroidism is described; others anomalies include elevated bone remodelling markers, damage of bone microarchitecture, fracture healing disturbances and sarcopenia. Conclusion. Overall, despite spectacular results after bariatric surgery, the bone and muscle are expected to suffer a level of deterioration, which should be taken into account for assuring an adequate quality of life and an immediate and distant good post-operatory prognosis.
A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults
Authors: Ma Liyuan , Ma Jinhai , Chen Xiaoyuan , Dong Linghua
Published: September 2021

Introduction: Brucellosis is a zoonosis with a wide spectrum of clinical manifestations. However, it is still unclear whether the clinical manifestations in children are significantly different from those in adults.

Methodology: Patients with brucellosis and treated at the General Hospital of Ningxia Medical University between 2009 and 2019 were divided into two groups; children (88) and adults (354). Thereafter, the records of the two groups were analyzed retrospectively.

Results: The findings showed that: 1. School-age children, young and middle-aged individuals were more likely to suffer from brucellosis and most were male; 2. Fever and arthralgia were the most common manifestations in the two groups. In addition, fatigue and low back pain were rare in children although fever and lymphadenopathy were more common in this group. However, hepatomegaly and splenomegaly were common in both groups; 3. The most common complication was osteoarthritis and peripheral arthritis occurred more frequently in children. On the other hand, spondylitis was the most common in adults (this particularly involved the lumbar and sacral vertebrae); 4. An increase in the erythrocyte sedimentation rate, levels of the C-reactive protein and liver enzymes was common in both two groups; 5. There was no significant difference in the positive rate of the standard agglutination test between children (96.59%) and adults (95.20%). However, the positive rate of blood culture was higher in children (65.85%) than in adults (51.00%).

Conclusions: Brucellosis causes damage to multiple systems and differences in clinical characteristics were found between children and adults.
COVID-19 in socially vulnerable quilombola populations in Salvaterra, Pará, Eastern Amazon, Brazil
Authors: Veiga Gonçalves Nelson , De Melo Neto João Simão , Kazumi da Trindade Noguchi Selma , Silva Machado Andrey , Da Silva Martins Junior Alcindo , Da Silva Peixoto Maira Cibelle , Lúcia Ribeiro Raithy Alba , Maia Costa Faria Camylle , Carvalho Garcia Miranda Filgueiras Tainara , Baima Amaral Júnior Alex , Do Socorro Carvalho Miranda Claudia
Published: September 2021

Introduction: COVID-19 is a severe respiratory syndrome caused by the SARS-CoV-2 virus. In Brazil the highest infection rates are associated with socially vulnerable populations. This study therefore sought to analyze the spatial distribution of the disease and its relation with geographic, socioeconomic and public health policy characteristics associated with quilombola communities in Salvaterra municipality, state of Pará, for the period of March to September, 2020.

Methodology: This cross-sectional and ecological study used data from the Disease Notification System and the National Registry of Health Establishments of the Ministry of Health, the Income Transfer Registry of the Ministry of Citizenship and the 2010 census of the Brazilian Institute of Geography and Statistics. Statistical and spatial analysis of the data was done through percentages of cases and Flow and Kernel map techniques.

Results: Seventy-five notified cases of COVID-19 distributed among 7 quilombola communities in the municipality were analyzed. The epidemiological profile followed a national trend, with a higher percentage of cases among persons who were female, adults with low schooling levels, working as family farmers and with an outcome ending in recovery. The spatial distribution of the disease was not homogenous and showed clusters of cases and high incidence rates, especially in communities close to the municipal seat or to highways.

Conclusions: The use of data analysis techniques was satisfactory for providing an understanding of the socioeconomic production of the disease in the areas studied. Accordingly, the need for intensifying epidemiological survey actions in the quilombola communities of the municipality is emphasized.
Human Papillomavirus Prevalence and Genotype Distribution in Cervical Swab Samples in Istanbul, Turkey
Authors: Alacam Sema , Bakir Ayfer
Published: September 2021

Introduction: Human papillomavirus (HPV) is the most common sexually transmitted infection agent worldwide and, with high-risk (HR) HPV genotypes, is the main factor for development of cervical cancer. This study aimed to assess the prevalence of HPV and distribution of HR-HPV genotypes in cervical swab samples and compare them with demographic and clinical data.

Methodology: Cervical swab samples of 2,285 women between the age of 17 and 76 were assessed between January 2018 and October 2020 in order to obtain the data of Turkey. Fifteen different HR-HPV genotypes were determined using multiplex real-time polymerase chain reaction test.

Results: HPV was positive in 36.3% (829/2,285) of DNA samples. Prevalence of multiple HR-HPV infection was 40.7%. Of the women, 30.9% (256/829) were infected with HPV16, 14.6% (121/829) with HPV39, and 14.2% (118/829) with HPV51. The most frequently detected genotypes with HPV16 were HPV31, HPV39 and HPV52, respectively. In women with cervical dysplasia, HPV16, 31, and 39 were the most common, and in women with genital warts, HPV16, 59 and 66 were most common, respectively. The highest HR-HPV prevalence was detected in the 17-34 age group (44.1%) (p < 0.001).

Conclusions: The prevalence of HR-HPV was 36.3% in this study. High prevalence (44.1%) especially in young women was consistent with findings in literature. The most common HR-HPV genotypes were HPV16, 39 and 51, respectively. Determining the prevalence and genotypes of HR-HPV playing role in the etiology of cervical cancer will be guiding for measures on prevention of cervical cancer and research on preventive vaccines.
The outcomes of severe COVID-19 pneumonia managed with supportive care in Palestine: an experience from a developing country
Authors: El-Hamshari Yousef , Hamarshi Majdi , Nazzal Zaher , Akkawi Amna , Saleh Dana , Abdullah Ibtesam , Najjar Mohammed , Rabi Razan , Ruzzeh Saad
Published: September 2021

Introduction: About 14% of COVID-19 patients experience severe symptoms and require hospitalization. Managing these patients could be challenging for limited-resource countries, such as Palestine. This study aimed to evaluate hospitalized severe COVID-19 patients' treatment outcomes managed with supportive care and steroids.

Methodology: This was a single-center observational retrospective cohort study that enrolled COVID-19 patients admitted to the “Martyrs medical military complex- COVID Hospital” in Palestine. The managing physicians manually collected data through chart reviews, including patients' characteristics, complications, outcomes, and different management modalities. Continuous and categorical variables between those who were discharged alive and who died were compared using t-test and Chi-squares test, respectively.

Results: Overall, 334 patients were included in this study. Median (IQR) age was 62(11) years, 49.1% were males, and 29.6% were ICU status patients. The median (IQR) PaO2/FiO2 ratio was 76 (67), and 67.6% of these patients had moderate to severe acute respiratory distress syndrome, and 4.8% of the patients received invasive mechanical ventilation. Most of the patients (78.7%) had at least one comorbidity, and 18.3% developed at least one complication. The overall mortality was 12.3% (95% CI 8.9-16.2%), and the median (IQR) length of hospital stay was 11 (8) days. Age (aOR 1.05, p = 0.08), smoking (aOR 4.12, p = 0.019), IMV (aOR 27.4, p < 0.001) and PaO2/FiO2 ratio (aOR 1.03, p < 0.001) were found to predict higher mortality.

Conclusions: Supportive care for patients with severe COVID-19 pneumonia in a Palestinian hospital with limited resources was associated with in-hospital mortality of 12.3%.
Assessment on risk and stress of resident doctors during the COVID-19 pandemic
Authors: Emre Nilufer , Edirne Tamer , Ozsahin Aysun , Kulceler Muhammed Fahrettin
Published: September 2021

Introduction: It has been noted that post-traumatic stress disorder symptoms could be common in physicians who have experienced a traumatic event. The aim of this study was to determine the prevalence of post-traumatic stress disorder and contributing risk factors among resident doctors working in a tertiary care hospital during the COVID-19 pandemic.

Methodology: A cross-sectional study was conducted via an online survey from May to July 2020. Sociodemographic characteristics, exposure to the coronavirus, application of personal hygiene rules, presence and use of personal protective equipment, anxiety and prevalence of post-traumatic stress disorder were investigated.

Results: In total, 17.8% (n = 40) of 225 resident doctors who participated in the study had post-traumatic stress disorder. Working at a department serving to COVID-19 patients increased the risk of post-traumatic stress disorder by 2.9 times (OR = 2.936, p = 0.003) while contacting positive patients increased this risk by 2.6 times (OR = 2.607, p = 0.023) and lack of personal protective equipment by 3.6 times (OR = 3.656, p = 0.018). Anxiety scores were statistically significantly higher in women, married and those living with their parents or spouses and children (p = 0.049; p = 0.011; p = 0.004, respectively).

Conclusions: Working in a department serving to COVID-19 patients, contact with positive patients and lack of personal protective equipment were risk factors in the emergence of post-traumatic stress disorder in resident doctors. Anxiety was also found to be greater in women, married and those living with their families.
A Preliminary Scoring Model to Predict In-hospital Mortality Risk for Geriatric Patients with Delirium
Authors: Astika Nyoman , Sindhughosa Dwijo Anargha , Kuswardhani R.A. Tuty , Manuaba Ida Bagus Amertha Putra
Published: September 2021

BACKGROUND: Elderly patients are at an increased risk of death, particularly those with altered mental status. AIM: We aimed to develop a scoring model from simple clinical data and routine laboratory testing to aid in predicting in-hospital mortality risk for geriatric patients with delirium. METHODS: A total of 73 hospitalized geriatric patients with delirium were included in the study. A multivariate regression analysis employed to obtain independent risk factors to predict in-hospital mortality. All patients were followed until dead or discharged from hospital. The formula of (B/SE)/lowest B/SE was used to calculate the scores for each variable with strong discrimination power to be included in scoring system. RESULTS: A total of 25 (34.2%) of patients were death when being hospitalized. The mean age of the patients was 73.27 ± 7.8. From a total of 20 probable variables, three variables were then included in constructing the scoring model; no caregiver (p < 0.012), abnormal diastolic blood pressure (p < 0.05), and abnormal serum SGOT levels (p < 0.03). Each variable was scored as 1, following the use of formula. Total score ranges from 0 to maximum of 3. The cutoff score of ≥ 2 provided the best accuracy with sensitivity of 40% and specificity of 89.6% (p < 0.001). The probability of in-hospital mortality was 8.8%, 32.6%, 70.8%, and 92.4% for the total score of 0, 1, 2, and 3, respectively. CONCLUSION: This novel scoring system with simple examination may aid to identify geriatric patients with delirium which possess higher risk for in-hospital mortality.
Association of Plasminogen Activator Inhibitor-1 and Cardiovascular Events Development in Patients with Prediabetes
Authors: Laryushina Yelena , Parakhina Viktoriya , Turgunova Lyudmila , Sheryazdanova Dinara , Dosmagambetova Raushan , Turmukhambetova Anar , Ponamareva Olga , Orbetzova Maria
Published: September 2021

Background. Plasminogen activator inhibitor-1(PAI-1) is a marker of endothelial dysfunction(ED) and a predictor of both the development of type 2 diabetes mellitus, and a cardiovascular event(CVE). Its role in the CVE development was sufficiently studied in patients without carbohydrate metabolism disorders, and understudied in patients with prediabetes.
Aim: the research interest is the study of PAI-1 in patients with prediabetes and its effect on the CVE development.
Materials and methods. The case-control study of 168 patients aged from 18 to 65 was carried out among the local population from January to December 2019.After clinical examination, patients were divided into 3 groups: group 1 (n=55)– patients with prediabetes and with CVE; group 2 (n=93) - patients with prediabetes and without CVE; the control group n=20.
Results. Differences in PAI-1 level were found in groups 1 (Me=30718.6 pg/ml) and 2 (Me=24692.0 pg/ml; p≤0.001), even greater differences were found in both groups compared to the control one (p≤0.001).
The correlation analysis has found in both group influence such IR indicators as fasting glucose, IR-HOMA index, glucagon, C-peptide to elevation of PAI-1. These findings indicate that with an elevation of the PAI-1 level, the concentration of fasting glucose, glucagon, C-peptide and scores of IR-HOMA index increase in both group.
The Binary regression analysis has demonstrated, that an elevation of the PAI-1 biomarker increases the likelihood of CVE by 3.3 fold in patients with prediabetes (p≤0.01). In addition to, a model has been derived for assessing the risk of cardiovascular events in patients with prediabetes.
Conclusions. Elevation of PAI-1 concentration is associated with insulin resistance which leads to ED, and further development risk of CVE in patients with prediabetes.
Identité des mots, identité des diagrammes : une approche kaplanienne ?
Authors: Gandon Sébastien , Longa Gianluca
Published: September 2021

Les conditions d’identité jouent un rôle fondamental dans le débat sur le statut épistémologique des diagrammes. À cet égard, les détracteurs comme les partisans de leur utilisation en tant que moyens de preuve partagent un même présupposé, qui consiste à étendre aux diagrammes la distinction entre type et token , normalement appliquée aux mots. Dans cet article, nous entendons discuter ce présupposé. Dans la première partie, nous montrerons que la distinction entre type et token , en tant que critère d’identité des mots, ne fait pas consensus en philosophie du langage. Nous verrons, en particulier, comment David Kaplan a rejeté ce critère et proposé une approche alternative, inspirée de la conception de la monnaie courante développée par Kripke. Dans la deuxième partie, nous étudierons la possibilité d’étendre aux diagrammes l’approche kaplanienne, par moyen de quelques considérations de caractère historique concernant la transmission des textes mathématiques grecs.
Examining the Necessity of Postoperative Day-1 Review After Pars Plana Vitrectomy: A Meta-Analysis
Authors: Bheemidi Abhinav R. , Roan Vivian D. , Muste Justin C. , Singh Rishi P.
Published: September 2021

BACKGROUND AND OBJECTIVES:

This study aimed to evaluate the necessity of the postoperative day-1 (POD1) review after pars plana vitrectomy.

PATIENTS AND METHODS:

The analysis included available literature that documented medical and surgical interventions performed on POD1 review after pars plana vitrectomy. A meta-analysis of proportions was conducted using a binomial-normal model to analyze three data sets consisting of all interventions, medical interventions, and surgical interventions. Heterogeneity and publication bias analyses were performed.

RESULTS:

POD1 reviews of 2,262 patients across 14 studies were examined to yield a total POD1 intervention rate estimate of 4.7% (95% confidence interval [CI], 3.0–13.9). When stratified by medical or surgical intervention, the intervention rate estimates were 4.1% (95% CI, 1.4–11.6) and 0.7% (95% CI, 0.3–1.3), respectively. The most common complication requiring postoperative intervention was elevated intraocular pressure.

CONCLUSION:

Given the wide confidence intervals of the estimated intervention rates, variability in postoperative practices, and range of interventions performed, the POD1 review cannot be discarded in its entirety.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:513–518.]
Impact of Anxiety Levels and Sleep Patterns on Perceived Pain During Intravitreal Bevacizumab Injections
Authors: Wieder Matthew S. , Szlechter Moshe , Fischman Noam , Inker Steven , Rusu Irene , Mbekeani Joyce N.
Published: September 2021

BACKGROUND AND OBJECTIVE:

To evaluate the impact of anxiety and sleep patterns on intravitreal injection pain.

PATIENTS AND METHODS:

This prospective, noninterventional study surveyed patients scheduled for intravitreal injection by two retinal surgeons. A standard intravitreal injection technique was used. Patients filled out pre-procedure General Anxiety Disorder-7 (GAD-7) and Pittsburgh Sleep Quality Index (PSQI) questionnaires. Post-procedural pain was assessed with a visual analogue scale. Quality and hours of sleep and anxiety levels were correlated with perceived intravitreal injection pain.

RESULTS:

A total of 140 patients met inclusion criteria. Mean ± standard deviation scores were 4.9 ± 5.6 for the GAD-7, 6.3 ± 4.1 for the PSQI, and 3.69 ± 2.64 for intravitreal injection pain. Anxiety correlated with intravitreal injection pain (rho = 0.25;
P
= .003). Previous night's sleep (rho = −0.16;
P
= .057) and poor sleep quality (rho = 0.14;
P
= .11) were weakly correlated. Regression analysis revealed anxiety was the only significant predictor of intravitreal injection pain. A 1-point increase in anxiety predicted a 0.10-point increase in intravitreal injection pain (B = 0.10,
P
= .032).

CONCLUSIONS:

Anxiety level was the best predictor of perceived pain. This has implications for pre-procedural anxiety screening.

[
Ophthalmic Surgery Lasers Imaging Retina
. 2021;52:498–504.]
Characteristics of Branch Retinal Vein Occlusion in African American Patients
Authors: Ma Justin P. , Robbins Cason B. , Thomas George N. , Kiew Sieh Yean , Yoon Stephen P. , Thomas Akshay S. , Fekrat Sharon
Published: September 2021

BACKGROUND AND OBJECTIVES:

To describe the presentation, management, and clinical outcomes of branch retinal vein occlusion (BRVO) in African American patients compared to patients of other racial or ethnic backgrounds.

PATIENTS AND METHODS:

This retrospective cohort study included eyes diagnosed with BRVO and macular edema at a tertiary referral center. Presenting features, treatment, and outcomes were compared based on racial or ethnic backgrounds.

RESULTS:

The study included 285 eyes: 21.8% African American, 78.2% other. African American patients were more likely to have comorbid diabetes (
P
= .012), open-angle glaucoma (
P
< .001), and to present with subretinal fluid (
P
= .049); multivariate analysis showed race and ethnicity alone may not fully explain presenting subretinal fluid (odds ratio = 2.807; 95% CI, 0.997 to 7.903;
P
= .051). There was no difference in other comparisons of clinical outcomes or treatment burden, including visual acuity, duration, or treatment method.

CONCLUSIONS:

Despite significant differences at presentation, the management and outcomes of BRVO did not differ significantly between African American patients and patients of other racial and ethnic backgrounds.

[
Ophthalmic Surg Lasers Imaging Retina.
2021;52:492–497.]
Macular Hole as a Complication Following Laser Photocoagulation for Retinopathy of Prematurity
Authors: Mammo Danny A. , Quiram Polly A.
Published: September 2021

Complications after laser photocoagulation for retinopathy of prematurity (ROP) are rare but do occur. To the best of our knowledge, we report a previously unreported case of a unilateral macular hole that developed after resolution of an exudative retinal detachment that resulted from laser photocoagulation for ROP. Confluent laser patterns in ROP in infants who have previously received intravitreal anti-vascular endothelial growth factor may result in adverse outcomes such as exudative retinal detachments. Even more rarely, a macular hole may develop.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:510–512.]
Sharp gradient estimates on weighted manifolds with compact boundary
Authors: Dung Ha Tuan , Dung Nguyen Thac , Wu Jiayong
Published: September 2021

In this paper, we prove sharp gradient estimates for positive solutions to the weighted heat equation on smooth metric measure spaces with compact boundary. As an application, we prove Liouville theorems for ancient solutions satisfying the Dirichlet boundary condition and some sharp growth restriction near infinity. Our results can be regarded as a refinement of recent results due to Kunikawa and Sakurai.
Classification of positive radial solutions to a weighted biharmonic equation
Authors: Yan Yuhao
Published: September 2021

In this paper, we consider the weighted fourth order equation

   \begin{document}$ \Delta(|x|^{-\alpha}\Delta u)+\lambda \text{div}(|x|^{-\alpha-2}\nabla u)+\mu|x|^{-\alpha-4}u = |x|^\beta u^p\quad \text{in} \quad \mathbb{R}^n \backslash \{0\}, $\end{document}

where \begin{document}$ n\geq 5 $\end{document}, \begin{document}$ -n<\alpha<n-4 $\end{document}, \begin{document}$ p>1 $\end{document} and \begin{document}$ (p,\alpha,\beta,n) $\end{document} belongs to the critical hyperbola

   \begin{document}$ \frac{n+\alpha}{2}+\frac{n+\beta}{p+1} = n-2. $\end{document}

We prove the existence of radial solutions to the equation for some \begin{document}$ \lambda $\end{document} and \begin{document}$ \mu $\end{document}. On the other hand, let \begin{document}$ v(t): = |x|^{\frac{n-4-\alpha}{2}}u(|x|) $\end{document}, \begin{document}$ t = -\ln |x| $\end{document}, then for the radial solution \begin{document}$ u $\end{document} with non-removable singularity at origin, \begin{document}$ v(t) $\end{document} is a periodic function if \begin{document}$ \alpha \in (-2,n-4) $\end{document} and \begin{document}$ \lambda $\end{document}, \begin{document}$ \mu $\end{document} satisfy some conditions; while for \begin{document}$ \alpha \in (-n,-2] $\end{document}, there exists a radial solution with non-removable singularity and the corresponding function \begin{document}$ v(t) $\end{document} is not periodic. We also get some results about the best constant and symmetry breaking, which is closely related to the Caffarelli-Kohn-Nirenberg type inequality.
Stability and bifurcation analysis of the Bazykin's predator-prey ecosystem with Holling type Ⅱ functional response
Authors: Wang Shuangte ,   School of Mathematics and Physics, Wenzhou University, Wenzhou 325035, China, Yu Hengguo ,   Liushi No.3 Middle School, Wenzhou 325604, China,   School of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China
Published: September 2021

In the paper, stability and bifurcation behaviors of the Bazykin's predator-prey ecosystem with Holling type Ⅱ functional response are studied theoretically and numerically. Mathematical theory works mainly give some critical threshold conditions to guarantee the existence and stability of all possible equilibrium points, and the occurrence of Hopf bifurcation and Bogdanov-Takens bifurcation. Numerical simulation works mainly display that the Bazykin's predator-prey ecosystem has complex dynamic behaviors, which also directly proves that the theoretical results are effective and feasible. Furthermore, it is easy to see from numerical simulation results that some key parameters can seriously affect the dynamic behavior evolution process of the Bazykin's predator-prey ecosystem. Moreover, limit cycle is proposed in view of the supercritical Hopf bifurcation. Finally, it is expected that these results will contribute to the dynamical behaviors of predator-prey ecosystem.
EMG-Based Essential Tremor Detection Using PSD Features With Recurrent Feedforward Back Propogation Neural Network
Authors: Sriraam Natarajan
Published: September 2021

Essential tremors (ET) are slow progressive neurological disorder that reduces muscular movements and involuntary muscular contractions. The further complications of ET may lead to Parkinson’s disease and therefore it is very crucial to identify at the early onset. This research study deals with the identification of the presence of ET from the EMG of the patient by using power spectral density (PSD) features. Several PSD estimation methods such as Welch, Yule Walker, covariance, modified covariance, Eigen Vector based on Eigen value and MUSIC, and Thompson Multitaper are employed and are then classified using a recurrent feedback Elman neural network (RFBEN). It is observed from the experimental results that the MUSIC method of estimating the PSD of the EMG along with RFBEN classifier yields a classification accuracy of 99.81%. It can be concluded that the proposed approach demonstrates the possibility of developing automated computer aided diagnostic tool for early detection of Essential tremors.
Utilization of Transfer Learning Model in Detecting COVID-19 Cases From Chest X-Ray Images
Authors: Jawahar Malathy , Anbarasi L. Jani , Jayachandran Prassanna , Ramachandran Manikandan , Al-Turjman Fadi
Published: September 2021

Diagnosis of COVID-19 pneumonia using patients’ chest X-Ray images is new but yet important task in the field of medicine. Researchers from different parts of the globe have developed many deep learning models to classify COVID-19. The performance of feature extraction and classifier plays a vital role in the recognizing the different patterns in the image. The pivotal process is the extraction of optimum features from the chest X-Ray images. The main goal of this study is to design an efficient hybrid algorithm that integrates the robustness of MobileNet (using transfer learning approach) to extract features and Support Vector Machine (SVM) to classify COVID-19. Experiments were conducted to test the proposed algorithm and it was found to have a high classification accuracy of 95%.
The Study of Para-Social Interaction With E-Word-of-Mouth for Influencer Marketing by Complex Computing
Authors: Yuan Yu-Hsi , Yeh Yi-Cheng , Wu Chia-Huei , Liu Cheng-Yong , Chen Hsin-Hao , Chen Chien-Wen
Published: September 2021

The purpose of this study was focused on exploring the relationship among the fans’ preferences, fans’ para-social interaction, and fans’ word-of-mouth. A survey consisted of 21 items based on the literature review and developed by this study. An online survey was distributed to the users of YouTube in Taiwan. A total of 606 valid samples was collected by survey. The instrument passed the reliability and validity test. Further, the data process applied the PLS (partial least squares) regression analysis methodology. The result shows that the ‘attractive’ impacted ‘para-social interaction’, ‘e-word-of-mouth’, and ‘preferences of fans’ positively. In addition, the para-social interaction plays an important role as a mediator between influencer’s attractiveness, w-word-of-mouth, and preferences of fans. Some suggestions were provided for social media influence’ related studies as reference.
Machine Learning Algorithms for Big Data Applications With Policy Implementation
Authors: Wu Jianzu , Zhang Kunxin
Published: September 2021

This article examines the policy implementation literature using a text mining technique, known as a structural topic model (STM), to conduct a comprehensive analysis of 547 articles published by 11 major journals between 2000 and 2019. The subject analyzed was the policy implementation literature, and the search included titles, keywords, and abstracts. The application of the STM not only allowed us to provide snapshots of different research topics and variation across covariates but also let us track the evolution and influence of topics over time. Examining the policy implementation literature has contributed to the understanding of public policy areas; the authors also provided recommendations for future studies in policy implementation.
A Conceptual Analysis on ‘ASEAN Way’ as a Normative Approach for Conducting Regional Affairs
Authors: Padmakumara S. C.
Published: September 2021

The role of Association of Southeast Asian Nations (ASEAN) has become more important in conducting regional affairs with its distinctive approach to interstate relations and regional cooperation. This distinctive practice is called as ‘ASEAN Way’ and the scholars assert that it is a pragmatic and informal approach to conduct intraregional affairs. As viewed by the scholars, what sets the ASEAN apart from many other regional institutions is its own process of decision-making, typically referred to as the “ASEAN Way’ (Weber, 2019). The ASEAN Way consists of a code of conduct for inter-state behavior as well as decision- making process based on consultations and consensus among its member states (Acharya, 1997). This ASEAN model or ‘ASEAN Way’ provides example of how a region can manage its problem and develop a positive identity in International Relations. Therefore, both in terms of intraregional and extra regional perceptions, Southeast Asia has become a symbol of a dynamic and largely peaceful region (Acharya, 2012). The central objective of this paper is to conceptualize the significance of ‘ASEAN Way’ as a distinctive approach to conduct regional affairs and highlight its implications for sustaining regional cooperation. The idea of ‘ASEAN Way’ is examined in this paper with specific reference to two important propositions. The first holds that ‘ASEAN Way’ is a normative approach to conduct intraregional affairs and it possess distinctive features compared to other regional practices. The second proposition holds that ‘ASEAN Way’ is potential as a mean for peaceful settlement of regional disputes. In order to realize these objectives, this study intends to answer these two research questions; what are the distinctive features of ‘ASEAN Way’ as an approach to conduct regional affairs and how it can be attributed as a peaceful mean for settling regional disputes. This study adopts a qualitative approach and primarily depends on the secondary data to answer the aforesaid research questions.
Insecticidal effect of Bacillus pumilus PTB180 and Bacillus subtilis PTB185 used alone and in combination against the foxglove aphid and the melon aphid (Hemiptera: Aphididae)
Authors: Kahia Mouna , Nguyen Thi Thuy An , McCune Frédéric , Naasz Rémi , Antoun Hani , Fournier Valérie
Published: September 2021

The foxglove aphid, Aulacorthum solani (Kaltenbach) (Hemiptera: Aphididae), and the melon aphid, Aphis gossypii Glover (Hemiptera: Aphididae), are among the serious insect pests found in greenhouses. The efficacy of microbial control against these insects has been demonstrated and can be enhanced by the combination of different microbial agents. This study evaluated the efficacy of Bacillus pumilus Meyer and Gottheil PTB180 and Bacillus subtilis (Ehrenberg) Cohn PTB185, used alone and together, to control these two aphids both in the laboratory and in greenhouse on tomato, Solanum lycopersicum Linnaeus (Solanaceae), and cucumber, Cucumis sativus Linnaeus (Cucurbitaceae), plants. The results from the laboratory tests showed an increase in mortality induced by all biological treatments. In the greenhouse, all treatments induced mortality rates significantly higher than that of the control for A. solani. Similarly, all treatments performed better than the control against A. gossypii, significantly reducing its reproduction. Furthermore, we found no additive effects when mixing products nor negative interactions affecting survival for the bacteria investigated. These microorganisms therefore have potential for use in biological control.
Remdesivir Efficacy in COVID-19 Treatment: A Randomized Controlled Trial
Authors: Abd-Elsalam Sherief , Ahmed Ossama Ashraf , Mansour Noha O. , Abdelaziz Doaa H. , Salama Marwa , Fouad Mohamed Hassan Ahmed , Soliman Shaimaa , Naguib Ahmed Mohamed , Hantera Mohamed Sayed , Ibrahim Ibrahim S. , Torky Mohamed , Dabbous Hany M. , El Ghafar Mohamed Samir Abd , Abdul-Baki Enas A. , Elhendawy Mohammed
Published: September 2021

To date, no antiviral therapy has shown proven clinical effectiveness in treating patients with COVID-19. We assessed the efficacy of remdesivir in hospitalized Egyptian patients with COVID-19. Patients were randomly assigned at a 1:1 ratio to receive either remdesivir (200 mg on the first day followed by 100 mg daily for the next 9 days intravenously infused over 30–60 minutes) in addition to standard care or standard care alone. The primary outcomes were the length of hospital stay and mortality rate. The need for mechanical ventilation was assessed as a secondary outcome. Two hundred patients (100 in each group) completed the study and were included in the final analysis. The remdesivir group showed a significantly lower median duration of hospital stay (10 days) than the control group (16 days; P < 0.001). Eleven of the patients in the remdesivir group needed mechanical ventilation compared with eight patients in the control group (P = 0.469). The mortality rate was comparable between the two groups (P = 0.602). Mortality was significantly associated with older age, elevated C-reactive protein levels, elevated D-dimer, and the need for mechanical ventilation (P = 0.039, 0.003, 0.001, and < 0.001 respectively). Remdesivir had a positive influence on length of hospital stay, but it had no mortality benefit in Egyptian patients with COVID-19. Its use, in addition to standard care including dexamethasone, should be considered, particularly in low- and middle-income countries when other effective options are scarce.
“Non vide mei di me chi vide il vero”: l’arte “verace” nel girone dei superbi come mise en abyme dell’arte dantesca nella Commedia
Authors: Maślanka-Soro Maria
Published: September 2021

“Non vide mei di me chi vide il vero”: L’art “verace” in the circle of proud as a mise en abyme of Dante’s art in the Comedy The purpose of this study is to discuss the problem of meta-poetic themes in the Divine Comedy, focusing in particular on the relationship between God’s art and Dante’s art in the context of the impression caused by the sight of the rock reliefs in the cornice of the proud in the Purgatorio, where the poet, presenting and imitating the art of God, in fact shows the mastery of his own art. The analysis leads to the conclusion that the examples of humility and pride carved on the walls and the rock path – the perfect work of God-the Artist, vibrant with life and called by Dante visibile parlare – are, on the one hand, a mise en abyme of its macroscopic version, which is the Universe created by him, and, on the other hand, a mise en abyme of the universe narrated with the simile perfection by Dante.
Les traductions polonaises des Lettres persanes de Montesquieu
Authors: Matyaszewski Paweł
Published: September 2021

Polish translations of Montesquieu’s Persian Letters The purpose of the present article is to show the history of Polish translations of a famous epistolary novel Persian Letters written in 1721 by Montesquieu. In his work, the author neither introduces linguistic matters of the translations, nor he analyses their correctness; however, he presents strictly historical and cultural aspects of the process of translation. What is more, the article aims at presenting the intentions of Polish translators, the historical context of their work and its importance for a Polish reader. Regardless of the era when they produced their translations, starting as early as the eighteenth century, Polish translators always saw in Montesquieu’s Persian Letters something more than a simple and light epistolary novel of the Regency era.
Mối quan hệ giữa hành vi thiếu văn minh của khách hàng và hành vi phá hoại dịch vụ của nhân viên trong ngành dịch vụ ở Việt Nam
Authors: An Nguyễn Duy , Wang Zhenyuan
Published: September 2021

Nghiên cứu nhằm mục đích tìm hiểu tác động của hành vi thiếu văn minh của khách hàng đối với hành vi phá hoại dịch vụ của nhân viên thông qua biến trung gian kiệt sức về cảm xúc và vai trò điều tiết của sự hỗ trợ từ tổ chức trong tác động trên. Với dữ liệu thu từ 449 nhân viên thường xuyên tiếp xúc với khách hàng tại Việt Nam, nghiên cứu phân tích nhân tố khẳng định, phân tích hồi quy thứ bậc và kiểm tra Bootstrap trên phần mềm PROCESS trong SPSS. Kết quả bài nghiên cứu cho thấy: Hành vi thiếu văn minh là tác nhân trực tiếp dẫn đến hành vi phá hoại dịch vụ; kiệt sức về cảm xúc có vai trò trong gian trong ảnh hưởng của hành vi không văn minh đối với hành vi phá hoại dịch vụ; sự hỗ trợ từ tổ chức điều tiết ảnh hưởng của hành vi thiếu văn minh đối với hành vi phá hoại dịch vụ thông qua việc làm giảm tác động ảnh hưởng hành vi thiếu văn minh đối với tình trạng kiệt sức về cảm xúc. Nghiên cứu làm phong phú và mở rộng các nghiên cứu trước đây về các yếu tố ảnh hưởng đến hành vi phá hoại dịch vụ của nhân viên ở Việt Nam. Ngoài ra, nghiên cứu cũng đưa ra một số đề xuất nhằm giảm thiểu các hành vi phá hoại dịch vụ.
Ảnh hưởng của lãnh đạo tư lợi đến sự kiệt sức về tinh thần, với vai trò trung gian của sự hoài nghi đối với tổ chức: Trường hợp người lao động trong doanh nghiệp Thành phố Hồ Chí Minh
Authors: Duy Trần Minh
Published: September 2021

Lãnh đạo tư lợi, sự hoài nghi đối với tổ chức và sự kiệt sức về tinh thần đang là những chủ đề được quan tâm gần đây, vì chúng gây ra ảnh hưởng tiêu cực đến các mặt quan trọng của tổ chức. Nghiên cứu này nhằm kiểm định lại các mối quan hệ trên tại bối cảnh ở Việt Nam và củng cố những kết quả của các nghiên cứu trước đây trên thế giới. Các mối quan hệ này được kiểm định thông qua mẫu khảo sát 336 người lao động đang làm việc tại Thành phố Hồ Chí Minh. Kết quả nghiên cứu cho thấy lãnh đạo tư lợi có tác động cùng chiều trực tiếp và gián tiếp đến sự kiệt sức về tinh thần thông qua vai trò trung gian của sự hoài nghi đối với tổ chức, và kết quả này phù hợp kết quả của các nghiên cứu trước đây. Từ đó, nghiên cứu này đã đóng góp những bằng chứng thực nghiệm về mối quan hệ giữa các khái niệm này. Ngoài ra, nghiên cứu cũng đưa ra một số hàm ý quản trị và giải pháp liên quan cho tổ chức về tăng cường hiệu quả lãnh đạo và giảm thiểu các ảnh hưởng tiêu cực.
Deteksi Otomatis Jerawat Wajah Menggunakan Metode Convolutional Neural Network (CNN)
Authors: Sudana Putra Fajar , Kusrini  , Kurniawan Mei P
Published: September 2021

Perkembangan tata rias di dunia belakangan ini semakin pesat perkembangannya. Perkembangan tersebut diimbangi dengan banyaknya kemunculan kosmetik dan skin care dari berbagai merk, namun tak sedikit juga efek negatif dari penggunaan yang ditimbulkan salah satunya adalah jerawat. Jerawat merupakan salah satu masalah pada kulit terutama wajah yang timbul secara fisiologis karena hampir setiap orang pernah mengalaminya (Wasitaatmadja, 2010). Jerawat terdiri dari berbagai jenis yaitu blackhead,whitehead,papula dan kista (Bhate, K. & Williams,2013). Tidak sedikit orang yang ingin menghilangkan dan terbebas dari jerawat. Perkembangan teknologi saat ini dalam bidang image prosessing dalam beberapa tahun ini dengan penerapan jaringan saraf convolutional menunjukkan kinerja yang begitu signifikan dengan memiliki tingkat akurasi yang tinggi, misalnya deteksi objek yang mana baru-baru ini memiliki restorasi gambar. Oleh karena itu perkembangan teknologi untuk mempermudah dalam penanganan jerawat sangat dibutuhkan tenaga medis khususnya dokter spesialis kulit. Penelitian ini fokus dalam pengembangan keakurasian metode menggunakan metode hough circle transform & Convolutional Neural Network (CNN). Penelitian ini membuktikan peningkatan akurasi dan ketepatan objek deteksi jerawat menggunakan metode Convolutional Neural Network (CNN). Hasil dari proses learning didapatkan model CNN dengan akurasi 99,8% hingga 100%, Sehingga dapat disimpulkan bahwa metode CNN yang dirancang pada penelitian ini dapat mengklasifikasi citra dengan baik.