bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanoscale covariance magnetometry with diamond quantum sensors
Authors: Rovny Jared , Yuan Zhiyang , Fitzpatrick Mattias , Abdalla Ahmed I. , Futamura Laura , Fox Carter , Cambria Matthew Carl , Kolkowitz Shimon , de Leon Nathalie P.
Published: December 2022

Nitrogen vacancy (NV) centers in diamond are atom-scale defects that can be used to sense magnetic fields with high sensitivity and spatial resolution. Typically, the magnetic field is measured by averaging sequential measurements of single NV centers, or by spatial averaging over ensembles of many NV centers, which provides mean values that contain no nonlocal information about the relationship between two points separated in space or time. Here, we propose and implement a sensing modality whereby two or more NV centers are measured simultaneously, and we extract temporal and spatial correlations in their signals that would otherwise be inaccessible. We demonstrate measurements of correlated applied noise using spin-to-charge readout of two NV centers and implement a spectral reconstruction protocol for disentangling local and nonlocal noise sources.
Invasive management of non-ST elevation myocardial infarction (NSTEMI) in a patient with severe thrombocytopenia secondary to adult-onset immune thrombocytopenic purpura
Authors: Shah Muhammad Usman , Muhammad Asif , Davison Benjamin , Naqvi Syed Yaseen
Published: December 2022

Managing patients with immune thrombocytopenic purpura (ITP) and thrombocytopenia is challenging when they present with acute coronary syndrome (ACS). They are at high risk of thrombotic events; however, antiplatelet medications may further lower the platelet count and predispose them to significant bleeding events, especially if undergoing percutaneous coronary intervention (PCI). We present a case of a man in his 70s, previously diagnosed with adult-onset ITP, admitted with ACS and severe thrombocytopenia. He was treated with a single antiplatelet and commenced on high-dose steroids. Once platelet levels had improved, he was started on second antiplatelet and underwent successful PCI with drug-eluting stent. He was safely discharged with dual antiplatelets for 1 month and then lifelong clopidogrel without any immediate complications. Our case shows that such patients, if stable, can be safely and successfully treated with steroids to improve platelet count before proceeding to invasive management and dual antiplatelet medications.
Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review
Authors: Brunner Laureline , Rodondi Nicolas , Aubert Carole Elodie
Published: December 2022

Objective

To synthesise the current knowledge on barriers and facilitators to deprescribing cardiovascular medications (CVMs) at the levels of patients, informal caregivers and healthcare providers (HCPs).

Design/setting

We conducted a systematic review of studies exploring/assessing patient, informal caregiver and/or HCP barriers and/or facilitators to deprescribing CVMs.

Data sources

Ovid/MEDLINE and Embase from January 2003 to November 2021.

Data extraction and synthesis

We performed a deductive thematic analysis based on the framework of specific barriers and facilitators to deprescribing CVMs created by Goyalet al. We added a quantification of the occurrence of categories and themes in the selected articles to identify the resounding themes that indicate the greater impetus to address in future research.

Results

Most frequent deprescribing barriers for patients, informal caregivers and HCPs included uncertainty due to lack of evidence regarding CVM deprescribing (in n=10 studies), fear of negative consequences following deprescribing (n=13) and social influences (n=14). A frequently reported facilitator to deprescribing, especially for patients and informal caregivers, was the occurrence of adverse drug events (n=7). Another frequently reported facilitator for patients were dislike of CVMs (n=9). Necessity and benefit of CVMs were seen as barriers or facilitators similarly by patients and HCPs.

Conclusion

The differences in patient, informal caregiver and HCP regarding barriers and facilitators to deprescribing CVMs stress the need for ground discussions about beliefs and preferences of each stakeholder implicated in deprescribing decisions. Furthermore, HCP uncertainty regarding CVM deprescribing highlights the need to provide HCPs with tools that enable sharing the risks and benefits of deprescribing with patients and ensure a safe deprescribing process.

PROSPERO registration number

CRD42020221973.
Concerns about and stimuli of COVID-19 vaccination hesitancy among diverse occupational groups in metropolitan areas of China: a cross-sectional study
Authors: Xie Zhilan , Tan Yinliang , Yan Yuge , Gu Xiaoqing , Chen Haiying , Huang Qian , Wang Zhaoxin , Gu Jie , Huang Jiaoling
Published: December 2022

Objectives

In this study, we aimed to identify concerns and stimuli regarding COVID-19 vaccination acceptance and to compare the findings by occupation.

Methods

We conducted a cross-sectional study of individuals vaccinated against COVID-19 between 1 April and 30 June 2021 in four metropolitan areas of China. A total of 20 863 participants completed questionnaires, 20 767 of which were eligible for analysis. We used ordered logistic regression to assess the association of vaccination concerns and stimuli with vaccination hesitancy according to occupation.

Results

Farmers were mainly concerned about the quality of vaccines (adjusted OR (aOR): 3.18, 95% CI (CI): 1.83 to 5.54). Among civil servants, media publicity reduced hesitancy (aOR: 0.44, 95% CI: 0.21 to 0.92). Among medical staff, concerns about a short duration of protective effects increased hesitancy (aOR: 8.31, 95% CI: 2.03 to 33.99). For most occupations, concerns about side effects, poor protective effects and health status increased hesitancy. In contrast, protecting oneself and protecting others acted as a stimulus to decrease hesitancy. Interestingly, ‘people around me have been vaccinated’ was associated with higher vaccination hesitancy among farmers (aOR: 2.19, 95% CI: 1.20 to 4.00).

Conclusion

The association of vaccination concerns and stimuli with vaccination hesitancy varied by occupation. The characteristics and concerns of specific target audiences should be considered when designing informational campaigns to promote vaccination against COVID-19.
Integration of a personalised mobile health (mHealth) application into the care of patients with brain tumours: proof-of-concept study (IDEAL stage 1)
Authors: Gvozdanovic Andrew , Jozsa Felix , Fersht Naomi , Grover Patrick James , Kirby Georgina , Kitchen Neil , Mangiapelo Riccardo , McEvoy Andrew , Miserocchi Anna , Patel Rayna , Thorne Lewis , Williams Norman , Kosmin Michael , Marcus Hani J
Published: December 2022

Objectives

Brain tumours lead to significant morbidity including a neurocognitive, physical and psychological burden of disease. The extent to which they impact the multiple domains of health is difficult to capture leading to a significant degree of unmet needs. Mobile health tools such as Vinehealth have the potential to identify and address these needs through real-world data generation and delivery of personalised educational material and therapies. We aimed to establish the feasibility of Vinehealth integration into brain tumour care, its ability to collect real-world and (electronic) patient-recorded outcome (ePRO) data, and subjective improvement in care.

Design

A mixed-methodology IDEAL stage 1 study.

Setting

A single tertiary care centre.

Participants

Six patients consented and four downloaded and engaged with the mHealth application throughout the 12 weeks of the study.

Main outcome measures

Over a 12-week period, we collected real-world and ePRO data via Vinehealth. We assessed qualitative feedback from mixed-methodology surveys and semistructured interviews at recruitment and after 2 weeks.

Results

565 data points were captured including, but not limited to: symptoms, activity, well-being and medication. EORTC QLQ-BN20 and EQ-5D-5L completion rates (54% and 46%) were impacted by technical issues; 100% completion rates were seen when ePROs were received. More brain cancer tumour-specific content was requested. All participants recommended the application and felt it improved care.

Conclusions

Our findings indicate value in an application to holistically support patients living with brain cancer tumours and established the feasibility and safety of further studies to more rigorously assess this.
Effects of flow rate and pore size variability on capillary barrier effects: a microfluidic investigation
Authors: Li Guang-yao , Zhan Liang-tong , Chen Yun-min , Feng Song , Zhang Zhi-hong , Du Xiu-li
Published: December 2022

Capillary barrier effects (CBEs) have been applied in capillary barrier systems as effective means of protecting underground regions from wetting. However, the microscale behavior of CBEs and related influencing factors are not well understood. This study utilized microfluidics to investigate effects of flow rate and pore size variability on CBEs at the microscale. Imbibition processes of water displacing air were imposed on three water-wet microfluidic chips with different degrees of pore size variability and injection rates. The obtained results demonstrated that the increasing injection rate changed water invasion pattern from finger growth to compact displacement. The CBEs could increase Swf (water saturation of fine sections at the onset of breakthrough) by up to 44%. The increase in Swf became smaller at a higher injection rate but was insensitive to the pore size variability within the investigation range. This study also elaborated the specific effect of inertia on pore body invasions under different pore characteristics. Among the materials with close average pore size, those with more uniform pore sizes are recommended for the construction of capillary barrier systems. For capillary barrier systems with robust CBEs, increasing the thicknesses of coarse layers has insignificant effect on reducing deep percolation.
Biochar applications to boreal podzol improve soil hydraulic properties and control nitrogen dynamics
Authors: Saha Ratnajit , Thomas Raymond , Hawboldt Kelly , Nadeem Muhammad , Cheema Mumtaz , Galagedara Lakshman
Published: December 2022

The study aimed to investigate the effects of biochar (BC) application on hydraulic properties and nitrogen (N) transport in a podzolic soil profile. Soil samples were collected from an agricultural research field in Pasadena, Newfoundland, Canada. The following three types of leaching columns were prepared: ( i) topsoil, ( ii) top and E-horizon soil, and ( iii) mixed soil (2:1 ratio of topsoil and E-horizon soil). Granular biochar (GBC) and powder biochar (PBC) were mixed with soils at the rate of 0%, 1% and 2% (w/w). BC’s morphological structure and pore size distribution were examined using a scanning electron microscope, and the specific surface area was assessed by the Brunauer−Emmett−Teller method. Soil physical and hydraulic properties (bulk density, porosity, field capacity (FC), permanent wilting point, plant available water (PAW)), leaching concentration of nitrate (NO3 −) and ammonium (NH4 +), and volume of leachate were measured through a total of 378 experiments under laboratory conditions. GBC and PBC showed hydrophobic and hydrophilic characteristics, respectively. With the 2% PBC amendment, porosity increased by 3%, FC by 10%, and PAW by 13% in the mixed soil and reduced NO3 − leaching by 36% in top and E-horizon soil and NH4 + leaching by 72% in mixed soil. On the other hand, NO3 − and NH4 + leaching was reduced by 26% and 33% in mixed soil when treated with 2% GBC. A 2% application rate for both BC (GBC and PBC) showed the best performance to enhance soil hydraulic properties and retain significant amounts of NO3 − and NH4 + in the boreal podzol.
Single-boson exchange functional renormalization group application to the two-dimensional Hubbard model at weak coupling
Authors: Fraboulet Kilian , Heinzelmann Sarah , Bonetti Pietro M. , Al-Eryani Aiman , Vilardi Demetrio , Toschi Alessandro , Andergassen Sabine
Published: December 2022

We illustrate the algorithmic advantages of the recently introduced single-boson exchange (SBE) formulation for the one-loop functional renormalization group (fRG), by applying it to the two-dimensional Hubbard model on a square lattice. We present a detailed analysis of the fermion-boson Yukawa couplings and of the corresponding physical susceptibilities by studying their evolution with temperature and interaction strength, both at half filling and finite doping. The comparison with the conventional fermionic fRG decomposition shows that the rest functions of the SBE algorithm, which describe correlation effects beyond the SBE processes, play a negligible role in the weak-coupling regime above the pseudo-critical temperature, in contrast to the rest functions of the conventional fRG. Remarkably, they remain finite also at the pseudo-critical transition, whereas the corresponding rest functions of the conventional fRG implementation diverge. As a result, the SBE formulation of the fRG flow allows for a substantial reduction of the numerical effort in the treatment of the two-particle vertex function, paving a promising route for future multiboson and multiloop extensions.

Graphic abstract
Parton distributions and new physics searches: the Drell–Yan forward–backward asymmetry as a case study
Authors: Ball Richard D. , Candido Alessandro , Forte Stefano , Hekhorn Felix , Nocera Emanuele R. , Rojo Juan , Schwan Christopher
Published: December 2022

We discuss the sensitivity of theoretical predictions of observables used in searches for new physics to parton distributions (PDFs) at large momentum fraction x. Specifically, we consider the neutral-current Drell–Yan production of gauge bosons with invariant masses in the TeV range, for which the forward–backward asymmetry of charged leptons from the decay of the gauge boson in its rest frame is a traditional probe of new physics. We show that the qualitative behaviour of the asymmetry depends strongly on the assumptions made in determining the underlying PDFs. We discuss and compare the large-x behaviour of various different PDF sets, and find that they differ significantly. Consequently, the shape of the asymmetry observed at lower dilepton invariant masses, where all PDF sets are in reasonable agreement because of the presence of experimental constraints, is not necessarily reproduced at large masses where the PDFs are mostly unconstrained by data. It follows that the shape of the asymmetry at high masses may depend on assumptions made in the PDF parametrization, and thus deviations from the traditionally expected behaviour cannot be taken as a reliable indication of new physics. We demonstrate that forward–backward asymmetry measurements could help in constraining PDFs at large x and discuss the accuracy that would be required to disentangle the effects of new physics from uncertainties in the PDFs in this region.
KELLY TRADING AND MARKET EQUILIBRIUM
Authors: BERMIN HANS-PETER , HOLM MAGNUS
Published: December 2022

The Kelly framework is the natural multi-period extension of the one-period mean-variance model of Markowitz in the sense that the efficient frontier is characterized by trading strategies having maximal instantaneous Sharpe ratio. We show that Kelly traders naturally trade in such a way as to induce an equilibrium for the instantaneous covariance matrix. This equilibrium, arising from trading alone, has the property that the equilibrium correlation can be described as the saddle point of a stochastic differential game. However, because the game is not necessarily a zero-sum game the equilibrium volatility is shown to be lower than what is predicted from the game. The covariance equilibrium is fully specified by the rate of logarithmic return, the interest rate and the aggregate willingness to leverage seen in the market.
A Frequency-Domain Formulation for Predicting Multi-Frequency Noise Generated by Flows with Periodically Moving Boundaries
Authors: Zhou Zhiteng , Wang Hongping , Zang Zhenyu , Wang Shizhao
Published: December 2022

A frequency-domain formulation is proposed to compute the far-field noise generated by flows with periodically oscillating or rotating boundaries. The proposed formulation significantly enhances the efficiency of the frequency-domain method in handling the multi-frequency sources with nonrectilinear motion. The novelty of the proposed method is that the frequency- and time-dependent components of the Ffowcs Williams and Hawkings (FW-H) integral are separated by using the far-field asymptotic Green’s function. The separation of the frequency- and time-dependent components avoids the need for an expensive time integration in computing the multi-frequency noise generated by flows with periodically moving boundaries. They proposed only one Fourier transform computation in obtaining the noise at different frequencies. The efficiency of the proposed formulation is investigated by analyzing the required number of floating-point operations. Its validity is examined by computing the noise from rotating or oscillating permeable boundaries around composite monopoles and a flapping wing. The proposed formulation is applicable to the FW-H integral with periodically oscillating or rotating boundaries when the maximum velocity on the moving boundary is subsonic.
Efficient Analysis of Energy-Based Surface Contributions for an Entire Acoustic Cavity
Authors: Gurbuz Caglar , Marburg Steffen
Published: December 2022

Sound radiation from vibrating structures is a crucial concern in the vehicle design process. One effective tool to recover vibration patterns on surfaces is the surface contribution analysis. Recent implementations, however, focus on surface contributions with respect to single evaluation points. For a contribution analysis regarding an entire volume, the tedious volume integration is required. This study aims to develop an efficient contribution analysis technique for the acoustic evaluation of an entire cavity. In order to circumvent the cumbersome volume integral, the acoustic quantities are evaluated at regularly distributed field points. For this purpose, the three-dimensional Helmholtz equation is solved by using the boundary element method. Moreover, the eigendecomposition of the accompanying coupling matrices is involved in the proposed method. In contrast to traditional techniques, the sound energy is deployed as the objective function, since the sound energy is not only sensitive to the sound pressure but also to the particle velocity. Another beneficial aspect is that the energy-based contributions are nonnegative. In this way, acoustic short circuits are avoided. The proposed method is validated for two numerical examples: the inward radiating sphere and the vehicle interior noise problem. Initial findings already reveal that entire volumes can be analyzed with the energy-based contribution analysis. By this means, our method designates an efficient method to evaluate contributing surfaces with regard to entire cavities. This research emphasizes the relevance of an energy-based contribution analysis, since they provide deep insights into the acoustic behavior of cavities.
A Randomized Controlled Trial of Dose Reduction of Biologic Therapy in Axial Spondyloarthritis: Rationale and Protocol of an Open-Label Non-inferiority Study and a Review of Literature
Authors: Chan Shirley Chiu Wai , Kwan Ian Yue Kit , Shum Wing Zi , Yeung Matthew Shi Chun , Chung Ho Yin
Published: December 2022

Axial spondyloarthritis (SpA) is a spectrum of inflammatory conditions predominantly involving the spine and sacroiliac (SI) joints. The development of biological therapies has revolutionized the treatment paradigm in SpA. This has led to a great improvement in clinical outcomes, including inflammation suppression, symptom alleviation, and functional improvement. Despite its usefulness, the question regarding the optimal duration of therapy remains unanswered. This is particularly important given the cost associated with biological therapies, and the potential side effects related to immune suppression. Currently, guideline and data regarding dose reduction of biologics treatment in axial SpA has not been well established. This randomized controlled trial aims to study the possibility of biologic dose reduction in patients with axial SpA. The primary measure will be the occurrence of disease flare up in participants undergoing biologics tapering compared with participants on standard dose of treatment. The study also aims to evaluate the role of anti-drug antibodies in disease flare, the effect of biologics dose reduction on structural changes, and the cost effectiveness of biologics dose reduction. The results of this study will be crucial for clinical decisions and establishing future guidelines regarding dose reduction of biologics in SpA.
Depositional environment and provenance of Early Carboniferous clastic sedimentary rocks at McIsaacs Point, Nova Scotia: implications for syntectonic basin development during the formation of Pangaea
Authors: Malay Bailey C. , Braid James A. , Archibald Donnelly B. , McFarlane Chris R. M.
Published: December 2022

Following the collision of Gondwana and Laurussia to form Pangaea, a large system of regional-scale strike-slip faults developed which resulted in the formation of transtensional syncollisional basins. One such basin, the Antigonish Basin, contains late Devonian fluvial, marine and lacustrine sedimentary rocks, including sandstone, conglomerate and shale. LA-ICP-MS U–Pb detrital zircon data from three samples from the lower and middle of the McIsaacs Point section have a strong Silurian–Devonian (
c.
440–380 Ma) population whereas the top of the section lacks these age populations and is instead dominated by Neoproterozoic (
c.
630–550 Ma) grains. Detritus was derived from a mix of local Avalonian and more distal Meguma terrane sources. Detrital zircon and field data show that sediments were deposited in a braided to meandering fluvial system transitional to a proximal braided stream environment followed by evolution to a more distal braided stream environment. As the basin evolved, the source of detritus shifted from a dominantly Meguma terrane source to a more local Avalonian source. This temporal evolution in provenance and depositional environment attests to the complex depositional processes associated with syntectonic basin evolution during the formation of Pangaea.
Detrital zircon geochronology from the Nueva Segovia Schist, Nicaragua: evidence for the tectonic evolution of the Chortis Block?
Authors: Freeborne Sean , Braid James A.
Published: December 2022

The Chortis Block of Central America is a cratonic-type peri-Gondwanan terrane and is commonly included in Neoproterozoic–Paleozoic palaeogeographical reconstructions. At present, most research has focused on the Mesozoic evolution of the Chortis Block, however, its earlier history remains poorly constrained. As a result, there is considerable debate surrounding the internal complexities of the Chortis Block and its tectonothermal evolution has not been well established by geochronological and geochemical data. New field investigations from the Nueva Segovia Schist (Northern Nicaragua), considered one of the oldest exposed parts of the Chortis Block, reveal it is composed primarily of deformed sequences of greenschist facies marine clastic and chemical sediments in conformable contact with felsic volcanics. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) detrital zircon data from two samples taken from the Nueva Segovia Schist reveal a youngest age peak of
c.
250 Ma with other significant peaks at
c.
500 Ma,
c.
1.0 Ga and
c.
1.2 Ga. Taken together with field observations, these data suggest the Nueva Segovia Schist was likely deposited between
c.
250 and 110 Ma proximal to Amazonia during the Late Paleozoic, and they support a Precambrian age for the basement of the East Chortis Terrane. Taken together the data support a Pangaean position of the Chortis Block, adjacent to Amazonia inboard of Oaxaquia.
The Effect of Penalty Factors of Constrained Hamiltonians on the Eigenspectrum in Quantum Annealing
Authors: Roch Christoph , Ratke Daniel , Nüßlein Jonas , Gabor Thomas , Feld Sebastian
Published: December 2022

Constrained optimization problems are usually translated to (naturally unconstrained) Ising formulations by introducing soft penalty terms for the previously hard constraints. In this work, we empirically demonstrate that assigning the appropriate weight to these penalty terms leads to an enlargement of the minimum spectral gap in the corresponding eigenspectrum, which also leads to a better solution quality on actual quantum annealing hardware. We apply machine learning methods to analyze the correlations of the penalty factors and the minimum spectral gap for six selected constrained optimization problems and show that regression using a neural network allows to predict the best penalty factors in our settings for various problem instances. Additionally, we observe that problem instances with a single global optimum are easier to optimize in contrast to ones with multiple global optima.
The Landscape of Computational Thinking Problems for Practice and Assessment
Authors: Pelánek Radek , Effenberger Tomáš
Published: December 2022

To provide practice and assessment of computational thinking, we need specific problems students can solve. There are many such problems, but they are hard to find. Learning environments and assessments often use only specific types of problems and thus do not cover computational thinking in its whole scope. We provide an extensive catalog of well-structured computational thinking problem sets together with a systematic encoding of their features. Based on this encoding, we propose a four-level taxonomy that provides an organization of a wide variety of problems. The catalog, taxonomy, and problem features are useful for content authors, designers of learning environments, and researchers studying computational thinking.
Let’s have that Conversation: How Limited Epistemological Beliefs Exacerbates Inequities and will Continue to be a Barrier to Broadening Participation
Authors: Ross Monique S.
Published: December 2022

A call to the computer science education community to make our values match our actions related to broadening participation through epistemological inclusion.
Flexible Graphite-Based Humidity Sensor Using Green Technology
Authors: Mansoori A. , Ahmad S. , Bansal Sonia , Vashishath M.
Published: December 2022

The low-cost graphite based pattern on cellulose paper was investigated in the present work. The graphite pattern used was fabricated by using normal inkjet printer on paper substrate that acted as working substrate as well as sensing material for humidity measurements. The quantitative electrical characterizations were measured by using different saturated salt-solutions producing relative humidity (RH) of 15%–92% at room conditions of 27 °C and 40%RH. The developed humidity sensor shows the sensitivity of 0.57 MΩ/%RH in the whole range of 15%–92%RH with a linearity co-efficient of R2 = 0.968, response (τ
res) and recovery (τ
rec) time of 294 s and 306 s respectively. The hydrophilic nature of the paper substrate is helpful for sensing, though the fabricated sensor is not so viable in terms of sensitivity, repeatability, and reuse but the method was simple, low-cost, bio-degradable, and use & throw which can be used for flexible and green electronics.
Development of the Physiology Professional Skills Curriculum Mapping Tool (PS-MAP)
Authors: Zubek J. , Johnson K. M. S. , Luttrell M. J. , Bryner R. W. , Choate J. K. , French M. B.
Published: December 2022

In addition to foundational physiology knowledge, undergraduate physiology and related STEM majors should develop a range of transferable professional skills. However, evidence of this curricular goal has been lacking. Therefore, the Professional Skills Committee of the Physiology Majors Interest Group (PMIG) developed the freely available and convenient Physiology Professional Skills Curriculum Mapping Tool (PS-MAP) to assist educators in mapping these professional skills throughout their programs.
A Cuproptosis-Related lncRNAs Signature Could Accurately Predict Prognosis in Patients with Clear Cell Renal Cell Carcinoma
Authors: Zhang Wei , Wang Han , Wang Wei , Xue Haoqiang , Qiao Maolin , Song Liying , Wang Shuang , Ren Zhaoyu , Ma Zhifang
Published: December 2022

Background. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancers. As cuproptosis, a new cell death mechanism proposed recently, differs from all other known mechanisms regulating cell death, we aimed to create prognostic markers using cuproptosis-related long non-coding ribonucleic acids (RNAs; lncRNAs) and elucidate the molecular mechanism. Methods. Data from transcriptome RNA sequencing of ccRCC samples and the relevant clinical data were downloaded from The Cancer Genome Atlas, and Pearson’s correlation analysis was implemented to obtain the cuproptosis-related lncRNAs. Then, univariate Cox, multivariate Cox, and Least Absolute Shrinkage and Selection Operator Cox analyses were performed to construct the risk signatures. The cuproptosis-related lncRNAs predictive signature was evaluated with receiver operating characteristic curves and subgroup analysis. Finally, Gene Set Enrichment Analysis (GSEA), single-sample GSEA (ssGSEA), tumor immune microenvironment (TIME), and immune checkpoints were performed to explore the relationship between immunity and patient prognosis. Results. Five cuproptosis-related lncRNAs, including FOXD2-AS1, LINC00460, AC091212.1, AC007365.1, and AC026401.3, were used to construct the signature. In the training and test sets, low-risk groups (as identified by a risk score lower than the median) demonstrated a better prognosis with an area under the curve for 1-, 3-, and 5-year survival being 0.793, 0.716, and 0.719, respectively. GSEA analysis suggested significant enrichment of the tricarboxylic acid cycle and metabolism-related pathways in the low-risk group. Besides, both ssGSEA and TIME suggested that the high-risk group exhibited more active immune infiltration. Conclusion. We proposed a cuproptosis-related lncRNAs signature, which had the potential for prognoses and prediction. Our findings might contribute to elucidating potential genomic biomarkers and targets for future therapies in the cuproptosis-related signaling pathways.
A Deep Intelligent Attack Detection Framework for Fog-Based IoT Systems
Authors: Gudla Surya Pavan Kumar , Bhoi Sourav Kumar , Nayak Soumya Ranjan , Singh Krishna Kant , Verma Amit , Izonin Ivan
Published: December 2022

Fog computing provides a multitude of end-based IoT system services. End IoT devices exchange information with fog nodes and the cloud to handle client undertakings. During the process of data collection between the layer of fog and the cloud, there are more chances of crucial attacks or assaults like DDoS and many more security attacks being compromised by IoT end devices. These network (NW) threats must be spotted early. Deep learning (DL) assumes an unmistakable part in foreseeing the end client behavior by extricating highlights and grouping the foe in the network. Yet, because of IoT devices’ compelled nature in calculation and storage spaces, DL cannot be managed on those. Here, a framework for fog-based attack detection is proffered, and different attacks are prognosticated utilizing long short-term memory (LSTM). The end IoT gadget behaviour can be prognosticated by installing a trained LSTMDL model at the fog node computation module. The simulations are performed using Python by comparing LSTMDL model with deep neural multilayer perceptron (DNMLP), bidirectional LSTM (Bi-LSTM), gated recurrent units (GRU), hybrid ensemble model (HEM), and hybrid deep learning model (CNN + LSTM) comprising convolutional neural network (CNN) and LSTM on DDoS-SDN (Mendeley Dataset), NSLKDD, UNSW-NB15, and IoTID20 datasets. To evaluate the performance of the binary classifier, metrics like accuracy, precision, recall, f1-score, and ROC-AUC curves are considered on these datasets. The LSTMDL model shows outperforming nature in binary classification with 99.70%, 99.12%, 94.11%, and 99.88% performance accuracies on experimentation with respective datasets. The network simulation further shows how different DL models present fog layer communication behaviour detection time (CBDT). DNMLP detects communication behaviour (CB) faster than other models, but LSTMDL predicts assaults better.
The Restoring Effect of Human Umbilical Cord-Derived Mesenchymal Cell-Conditioned Medium (hMSC-CM) against Carbon Tetrachloride-Induced Pulmonary Fibrosis in Male Wistar Rats
Authors: Khajvand-Abedini Maryam , Bahmani Mahdi , Ziamajidi Nasrin , Nourian Alireza , Habibi Parisa , Heidarisasan Shirin , Abbasalipourkabir Roghayeh
Published: December 2022

Objective. Pulmonary toxicity induced by CCl4, a model of idiopathic pulmonary fibrosis (IPF), leads to tissue remodeling and inflammation. Human umbilical cord mesenchymal cell-conditioned medium (hMSC-CM) is a potent anti-inflammatory, antioxidative, and antifibrotic agent. Methods. Forty male Wistar rats were assigned to the control (C), olive oil control (C.O) (hMSC-CM), control (C.Ms), fibrosis (fb), and fibrosis with hMSC-CM (f.Ms) treatment groups. The groups C, C.O, and C.Ms received PBS (200 µl), olive oil (1 ml/kg), and hMSC-CM (100 μg protein/kg), respectively. The fibrosis group was administered with only CCl4 (1 ml/kg). The last group, f.Ms was treated with CCl4 (1 ml/kg) and 100 μg protein/kg IV hMSC-CM. While the treatment with olive oil and CCl4 was performed for 2 days/week from the first week for 12 weeks, the treatment with PBS and hMSC-CM was carried out 2 days/week from week 4th to week 12th. The effect of the UC-MSC culture medium treatment on the lung was evaluated by assessing lysyl oxidase (LOX), tumor necrosis factor-alpha (TNF-α), and transforming growth factor-β1 (TGF-β1) genes, and proteins expression by real-time RCR and western blotting, respectively. Results. Lysyl oxidase (LOX), tumor necrosis factor-alpha (TNF-α), transforming growth factor-b1 (TGF-β1), malondialdehyde (MDA), and oxidative stress levels were markedly higher in the fibrosis group than in the control groups (

p
≤
0.001

). Additionally, glutathione (GSH) in the fibrosis group was markedly lower than those in the control groups (

p
≤
0.001

). Fibrosis in the UC-MSC treatment group had milder histopathological injuries than in the fibrosis group. Conclusion. hMSC-MSC as a strong anti-inflammatory, antioxidative, and antifibrotic decreases the level of oxidative stress, proinflammatory cytokines, and MDA causing a restoring effect against CCl4-induced pulmonary fibrosis.
Intelligent Recommendation Algorithm Combining RNN and Knowledge Graph
Authors: Zeng Fengsheng , Wang Qin
Published: December 2022

With the continuous application and development of big data and algorithm technology, intelligent recommendation algorithms are gradually affecting all aspects of people’s daily life. The impact of smart recommendation algorithm has both advantages and disadvantages; it can facilitate people’s life, but also exists at the same time the invasion of privacy, information cocoon, and other problems. How to optimize intelligent recommendation algorithms to serve the society more safely and efficiently becomes a problem that needs to be solved nowadays. We propose an intelligent recommendation algorithm combining recurrent neural network (RNN) and knowledge graph (KG) and analyze and demonstrate its performance by building models and experiments. The results show that among the five different recommendation models, the intelligent recommendation algorithm model combining RNN and knowledge graph has the highest AUC and ACC values in the Book-Crossing and MovieLens-1M. At the same time, the algorithm’s rating prediction error values are small (less than 2%) in extracting different users’ ratings for different books. In addition, the intelligent recommendation algorithm combining RNN and knowledge graph has the lowest RMSE and MAE values in the comparison of three different recommendation algorithms, indicating that it has better performance and stability, which is important for the improvement of user recommendation effect.
CDCA2 Promotes HCC Cells Development via AKT–mTOR Pathway
Authors: Li Kai , Fan Tingting , Shi Zhongxing , Jiang Huijie
Published: December 2022

Background. Hepatocellular carcinoma (HCC) is a highly aggressive and solid malignancy with a poor prognosis. Cell division cycle associated 2 (CDCA2) is highly expressed in HCC and is considered to be closely related to the prognosis of patients with HCC. In this research, we aimed to investigate the function and potential mechanism of CDCA2 in HCC cells. Methods. Gain- and loss-of-function experiments were conducted to determine the biological function of CDCA2 in HCC cells. Quantitative reverse transcription-polymerase chain reaction and western blot were utilized to examine the Messenger RNA (mRNA) and protein levels of CDCA2 in HCC cells. The malignant behaviors of HCC cells were analyzed by several biological experiments including cell viability, cell colony formation, and transwell assays. Western blot was also implemented to examine the expression of : AKT, protein kinase B and mTOR, mammalian target of rapamycin (AKT–mTOR) pathway related proteins and Cyclin D1. Results. A significant increase of CDCA2 was observed in HCC cell lines. Upregulation of CDCA2 resulted in the enhancement of the growth, migration, and invasion of HCC cells. Inversely, depletion of CDCA2 displayed the opposite results. Furthermore, the protein levels of p-AKT, p-mTOR, and Cyclin D1 were elevated with CDCA2 upregulation and reduced with CDCA2 depletion in HCC cells. Conclusion. Our observations revealed that CDCA2 promoted the malignant development of HCC cells, and AKT–mTOR pathway might involve in the underlying mechanism.
Impact of Pretransplant Salvage Therapies on Outcome of Hodgkin Lymphoma Patients Performing Allogeneic Transplant
Authors: Fanelli Fulvia , Hohaus Stefan , Cantonetti Maria , Cimino Giuseppe , Pennese Elsa , Battistini Roberta , Galli Eugenio , Cerretti Raffaella , Proia Anna , Fatone Federica , Provenzano Ida , Abruzzese Elisabetta , Finolezzi Erica , Pulsoni Alessandro , Rigacci Luigi
Published: December 2022

Background: Allogeneic transplant is an effective salvage therapy in patients with Hodgkin lymphoma (HL) relapsed or refractory (R/R) to previous treatments. In recent years, immunotherapies (conjugated antibody and checkpoint inhibitors [CPI]) showed interesting results and were used as bridge therapies to allotransplant. Aim: The aim of this retrospective study in Lazio region was to evaluate the impact of these new therapies on outcome after allogeneic hematopoietic stem cell transplantation (allo-SCT) in comparison with standard chemotherapies used in the past. Methods: We selected all consecutive patients with diagnosis of HL transplanted in four hematology transplant units, and we collected data obtained from patients’ records concerning all the treatments before allo-SCT. Results: A total of 56 patients were enrolled in this study. All patients underwent allo-SCT for R/R HL. Seventeen patients (30%) received chemotherapy prior to allo-SCT (group B); they were treated between 2008 and 2015; and 39 patients (70%) received brentuximab vedotin (BV), CPI, or both before allo-SCT as a bridge to transplant (group A); they were treated between 2012 and 2020. Twenty-five patients were treated with BV alone, 2 with CPI alone, and 12 first with BV and then with CPI. No patient received concomitant BV and CPI. At 5 years from allo-SCT, overall survival (OS) was 59% and progression-free survival (PFS) was 65%. No statistical differences in OS or PFS were observed between patients in groups A and B. Relapse was significantly associated with a lower survival. The only factor associated with a reduced risk of relapse was development of any grade acute graft versus host disease (GVHD) (p > 0.02). Conclusions: This regional real-world experience shows the changes that have taken place in the last 10 years in R/R HL using new drugs to render a patient eligible for allo-SCT. This strategy appears to guarantee an impressive disease control with an increased risk of complications, for example, aGVHD, that appear to nullify this advantage at least in part.
Traumatic Orbital Floor Fracture Causing Therapeutic Orbital Decompression in Thyroid Eye Disease
Authors: Buoniconti Patrick , Magidenko Maria , Hassan Adam
Published: December 2022

This is a case of a 67-year-old female with a history of Graves’ disease and associated thyroid eye disease who presented to the emergency room after falling and hitting her head. Subsequently, she noted periorbital air on the left side when blowing her nose. A CT scan in the emergency room revealed a left orbital floor fracture and decompression of the left orbit. While nonsurgical orbital decompression in the setting of Graves’ eye disease has been reported in several instances, spontaneous ethmoid bone remodeling or fracture has been the most cited mechanism, with rarer instances of true spontaneous orbital floor fracture. Furthermore, there exist only two known case reports of traumatic orbital floor fractures with subsequent orbital decompression in the setting of thyroid eye disease. In only one of the two known cases, therapeutic effect was established. However, no significant follow-up period was noted. This case represents a rare traumatic orbital floor fracture resulting in orbital decompression with demonstrably improved exophthalmos. It is the first to include definitive follow-up both before and after operative management of the contralateral orbit.
Accuracy of Two Visual Criteria for the Assessment of Caries around Restorations: A Delayed-Type Cross-Sectional Study
Authors: Stolfo Uehara Juliana Lays , Signori Cácia , Digmayer Romero Vitor Henrique , Mendes Fausto Medeiros , Cenci Maximiliano Sérgio ,   CaCIA collaborative group
Published: December 2022

The aim of this study was to compare the performance of two visual criteria used for the detection of caries around restorations in permanent teeth. In this delayed-type cross-sectional study, the study sample was randomly allocated to one of two visual criteria for the assessment of restorations as follows: (a) International Dental Federation (FDI) criteria, considers marginal staining, marginal adaptation, and caries recurrence and (b) Caries Associated with Restorations or Sealants (CARS) criteria, defined by the International Caries Classification and Management System. A calibrated examiner assessed the restorations using two reference standards as follows: (i) for restorations requiring operative interventions (repair/replacement), the restoration was partially or totally removed and the presence or absence of carious tissue was assessed; and (ii) for restorations requiring nonoperative intervention, follow-up for a period of 1 year was recommended to allow identification of the presence of new lesions not detected at baseline. The sensitivity, specificity, area under receiver operating characteristic curve (Az), and accuracy of the criteria were assessed. The study included 305 restorations. The FDI marginal staining parameter had the lowest Az value (Az = 0.501), while similar sensitivity was observed between the CARS (62.0%), FDI presence of caries (65.0%), and FDI marginal adaptation (74.0%) parameters. CARS exhibited the highest specificity (88.3%) and accuracy (85.6%). The CARS criteria exhibited better specificity and accuracy in detecting caries around restorations, followed by the FDI criteria for caries recurrence and marginal adaptation. Considering marginal staining or combining multiple marginal features to assess secondary caries resulted in an increased risk of false-positive outcomes and overtreatment.
Problematizando a Pós-Custódia com a contemporaneidade da Cadeia de Custódia Digital Arquivística compartilhada e distribuída na Preservação Digital Sistêmica
Authors: Gava Tânia Barbosa Salles , Flores Daniel
Published: December 2022

Este artigo tem como objetivo problematizar a pós-custodia com a contemporaneidade da custódia digital compartilhada e distribuída na Preservação Digital Sistêmica, contemplando tanto a ruptura de paradigma quanto a transição paradigmática da cadeia de custódia arquivística do ambiente analógico para o ambiente digital. Em relação aos objetivos, a metodologia adotada foi a pesquisa exploratória. Em relação aos procedimentos metodológicos, trata-se de uma pesquisa bibliográfica e documental. O artigo traz como principais resultados a problematização da Arquivologia pós-custodial, principalmente na visão de Terry Cook, repensando os conceitos envolvidos, principalmente o conceito de custódia no contexto da Preservação Digital Sistêmica, perpassando todos os ambientes envolvidos no ciclo de vida dos documentos, que são o ambiente de gestão de documentos, o ambiente de preservação e o ambiente de acesso e difusão. Concluímos que na preservação digital sistêmica deve-se prever uma cadeia de custódia arquivística ressignificada para o ambiente digital, ou seja, uma Cadeia de Custódia Digital Arquivística (CCDA) que deve ser compartilhada com os papeis de administrador de preservação e administrador de TI (Tecnologia da Informação) e distribuída em diferentes locais e diferentes tipos de armazenamento, como o armazenamento em nuvem.
Estudos e práticas de Catalogação na Itália: a experiência de Lucia Sardo
Authors: Zafalon Zaira Regina , Silva Márcia Regina da , Crippa Giulia
Published: December 2022

Entrevista com Lucia Sardo
Dramaturgia como performance alegórica
Authors: Koudela Ingrid Dormien
Published: December 2022

A dramaturgia vem sendo objeto de expansão que opera dentro da própria lógica de sua estrutura. Neste artigo, procuro demonstrar a história dos avanços estéticos que trazem em seu bojo implicações para a performance. Como método pedagógico e de encenação, suas características híbridas apontam o rompimento com inúmeros cânones do teatro tradicional. Uma performance alegórica parte de referências historicamente informadas, destacando que o texto e/ou a imagem deixa de ser uma figuração ilustrativa, tornando-se um espaço de jogo entre a alegoria e o imaginário do leitor, atuante ou espectador.
Flora da Serra do Cipó, Minas Gerais: Malvoideae (Malvaceae)
Authors: Camargo Rafaela Passos , Bezerra Flávia de Oliveira , Yoshikawa Vania Nobuko , Esteves Gerleni Lopes , Duarte Marília Cristina
Published: December 2022

O presente estudo compõe parte do projeto “Flora da Serra do Cipó, Minas Gerais, Brasil”. Malvoideae representa a maior das nove subfamílias de Malvaceae sensu lato. Como caráter diagnóstico da subfamília há a presença de frutos esquizocárpicos ou cápsula, no entanto, algumas características típicas não-sinapomorficas podem ser encontradas em Malvoideae, sendo elas a presença de folha simples inteiras, partidas ou lobadas, epicálice geralmente presente, estames geralmente numerosos em um tubo estaminal, flores congestas ou solitárias no ápice ou na axila dos ramos. Na área de estudo foram encontrados dez gêneros (Abutilon, Gaya, Herissantia, Hibiscus, Malvastrum, Pavonia, Peltaea, Quararibea, Sida e Wissadula) e 27 espécies, sendo diferenciados principalmente pela presença de epicálice, características do fruto e mericarpos. O gênero Sida se mostrou mais frequente, com dez espécies. Chaves de identificação em nível genérico e específico, bem como descrições detalhadas, ilustrações, comentários taxonômicos e lista de material examinado são também apresentados. A partir disso, a monografia de Malvaceae para a Serra do Cipó é finalizada, sendo incluída uma chave de identificação de subfamílias neste trabalho.