bluuebunny/crossref_metadata_2025 huggingface dataset:
An Overview on Sources, Biosynthesis and Bioactivities of Osthole: A
Potential Bioactive Compound
Authors: Singh Gurdeep , Singh Mukesh Kr.
Published: March 2023

Different plants are rich in medicinal properties, which nature has provided in abundance
for the living beings of this earth. Since the dawn of time, nature has proven to be a rich
source of bioactive scaffolds that have been exploited in the creation of pharmaceuticals. Osthole
is a natural coumarin derivative and potential bioactive compound found in plants. Herein, we
aimed to review the origins, biology and pharmacological profiles of osthole, a plant-derived
coumarin that is found in a variety of therapeutic plants, including Cnidium monnieri. Osthole,
also called 7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one, is a naturally occurring
coumarin found to be present in different plants of the Apiaceae family, i.e., Cnidium monnieri
and Angelica pubescens. The biological potential of the osthole in medicine has been investigated
using a variety of literature databases. This study gathered diverse scientific research data on
osthole from various literature sources and analysed, including Scopus, Google Scholar, Web of
Science and PubMed. From the collected data, it was found that osthole have potential pharmacological
activities, such as anticancer, antioxidant, osteogenic, cardioprotective, antimicrobial, antiparasitic,
anti-hyperglycaemic, neuroprotective, and antiplatelet. The data in this review paper
supports the pharmacological potential of osthole, but to completely appreciate the pharmacological
potential of this therapeutically powerful chemical, researchers must focus their efforts on further
experimentation, biosafety profiling and synergistic effects of this compound. The purpose of
this study was to learn more about the origins, biology, and therapeutic benefits of osthole in medicine
in order to develop better treatments for human diseases.
Molecular Pathology and Therapeutic Strategies of Type 2 Diabetes
Authors: Liao Helen Ziqing , Liang Yanting , Wang Ye , Liang Chun
Published: March 2023

Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia. Over the years, scientists have identified many factors that may have causal relationships with DM develop-ment. Identified factors are either genetic or environmental, and they may promote or prevent DM development. This review discusses various factors that are involved in the molecular pathogenesis, development, and therapeutic strategies of type 2 diabetes. DM is caused by interactions between multiple factors and triggers. Altered metabolic pathways and cellular functions, primarily in organs involved in glucose metabolisms, such as the pancreas and liver, often result in metabolic dysfunc-tion, leading to DM. Additionally, abnormal levels of some factors, the presence of some pathogens, or the use of some types of medicine, such as immuno-inflammatory mediators, glucagon, apolipo-protein E4, chromogranin-A, exosomes, vitamin D, viruses, glucocorticoid medication, and antipsy-chotic drugs, may play roles in the development of DM. Some of these factors and mechanisms are well-studied, while others are more controversial and have contradicting experimental results. Further research is needed to confirm the roles of these factors in DM and fully understand how they contrib-ute to DM development. Numerous medications for diabetics have been developed to help alleviate the symptoms of hyperglycemia and its complications. Several types of small compounds or peptide drugs with anti-diabetic effects can decrease blood glucose levels, improve insulin resistance, and inhibit key enzymes involved in the development and progression of diabetes. Here, we review the commonly used effective antidiabetic drugs, including the most recent innovative ones, such as GLP-1R/GIPR and GLP-1R/GCGR agonists, and Chinese medicine.
Effects of architectural space design on predicting turning in daily life
Authors: Matsunami Y.
Published: March 2023

Abstract. In recent years, the diversification of lifestyles and the increase in the number of elderly single-person households have increased the need to introduce robots and sensors into living spaces to control living spaces appropriately for individuals. To realize these goals, it is necessary to predict people’s non-steady motions which is one of the challenges in introducing robots into living spaces. In response, we have conducted research on motion prediction systems using robots and sensors. These studies will contribute to the realization of safe and comfortable architectural spaces by introducing robots into living spaces and collaborating with various space controls such as automatic doors and lighting. In this study, we focused on turning related to walking, which is the most basic motion in activities of daily living. As turning is a non-steady motion greatly affected by aging and disease, it is difficult to predict while is highly useful as a health indicator. Previous studies have suggested that architectural space design can influence the prediction of turning, but the actual effects are not clear because these studies were conducted only under highly constrained conditions in a laboratory environment. Thus, existing systems for predicting turning have not been validated in daily living environments due to issues such as instructions of motions to participants, limitations of natural motions because of contact sensors, and validation in experimental environments that are specially prepared to ensure reproducibility. Therefore, the purpose of this study was to introduce our sensing systems into actual living spaces and to validate our turning prediction system using acquired data on participants’ natural motion. In addition, the influence of architectural space design on predicting turning was clarified by conducting an experiment at a T-junction with an open space and a crossroad with poor visibility. In this study, an office space was selected as the experimental field as a living space to verify the feasibility of our turning prediction system.
Seismic damage assessment of building with strong non-linearity based on particle filter
Authors: Hida T.
Published: March 2023

Abstract. Various structural health monitoring (SHM) methods based on system identification using strong motion records of buildings were proposed in previous studies. Methodologies based on linear state-space models such as subspace state-space system identification (4SID) [1][2] were often used to assess the structural damage in past studies. However, it is inappropriate to apply methods based on linear state-space representations when evaluating damage to buildings that exhibit strong nonlinearity, such as wooden structures that were severely damaged due to an earthquake. To evaluate the seismic damage of a building, it is desirable to observe the strong motion on all floors of the building. However, such cases are rare in real buildings due to various restrictions such as cost and/or spatial limitation. Based on the background mentioned above, this paper investigates the applicability of the particle filter [3][4] to assess the structural integrity of highly nonlinear buildings using the strong motion records observed on a limited number of floors.
High-precision dimensional measurement of a curtain wall cross-section using image super-resolution
Authors: Park J.S.
Published: March 2023

Abstract. Dimensional quality is critical to the successful installation of curtain walls, and the required dimensional tolerances are typically less than a millimeter. However, high-precision dimensional measurement of a curtain wall cross-section is practically difficult and time-consuming because the cross-sectional shapes are various and complicated, and dimensional measurement is usually performed manually in the actual field. To improve these problems, various vision-based methos are being attempted, but there have been limitations in terms of precision due to row image resolution. Therefore, this study confirmed whether image super-resolution can contribute to overcoming these limitations. To this end, an experiment on a curtain wall profile cross-section was conducted, and super-resolution generative adversarial network (SRGAN) was applied as an image super-resolution method. As a result, it was confirmed that high-precision dimensional measurement is possible from an image with enhanced resolution using SRGAN.
Carbon black enhanced cementitious composites for self-sensing micro strain
Authors: Shi Z.
Published: March 2023

Abstract. As one of the non-destructive test methods, self-sensing cementitious composites have been developed for concrete structures to monitor the health condition. In this study, the focus was put on the self-sensing capacity for low amplitude strain which was often overlooked in the previous research. Carbon black nanoparticles were added as conductive filler in cementitious composites and their piezo-resistivities were recorded in low-amplitude cyclic loadings. Besides, hammer induced stress wave was utilized to activate the self-sensing mechanism in composites. Because the tunnelling effect occurs at several nanometres and is extremely sensitive to the micro strains, these signals were collected as the electrical resistance variance between two closely contacted electrodes and compared with the signals from lead zirconate titanate (PZT) sensors. The developed materials provides the potential of high-resolution strain measurement and stress wave detection without any external instruments.
Integration of wearable and ambient sensors towards characterization of physical effort
Authors: Appelle A.
Published: March 2023

Abstract. Human performance monitoring in complex operational environments calls for sensing solutions that measure human physiology as well as human interactions with their surroundings. Recent advances in multimodal sensing have led to the development of intelligent environments that analyze human activities with high granularity. One of the greatest challenges is to unify multiple discrete sensing systems through synchronization and integration of multimodal data streams. This paper describes an intelligent environment that consolidates wearable skin-strain sensors for physiological monitoring; geophones and microphones to record ambient vibrations and sounds; and video cameras to visually observe human activities. We show proof-of-concept functionality by using the system to differentiate walking effort in human subjects. First, the work shows the alignment of wearable and ambient sensor time-history records. Then, data features are extracted and correlated to walking speed using three sensor modalities. Finally, feature-level analysis is done to associate the data features with the perceived walking exertion for each subject.
Prediction of speed limit on the railway track using track quality index and multibody dynamics simulation
Authors: Widyastuti H.
Published: March 2023

Abstract. The performance of track conditions must be thoroughly assessed to ensure the safe operation of the train that travels through the track. The Track Quality Index (TQI) is used to determine the condition of the railway track. The TQI value is a statistical summary of track geometry parameters measured over a specified track length. There are several methods used to analyze TQI including the Indonesian Railway standard (PT. KAI). The KAI’s analysis method of the TQI is a sum up of four parameters which are alignment, longitudinal level, cross-level, and track gauge. Moreover, TQI is used to determine the speed limit allowed for the train to pass through the track. A multibody dynamic system simulation was recently performed as a reference to compare track quality assessments based on driving safety and vertical loads on rails, in which one of the outputs is the speed limit. This result shows that the speed limit based on the multibody system is slightly lower at certain segments compared to the TQI.
Study of Glass Ceramics with YNbO-=SUB=-4-=/SUB=- : Tb-=SUP=-3+-=/SUP=- Crystallites Synthesized at Different Temperatures
Authors: Kravets V. A.  , DementevaE.V.  , ZamoryanskayaM.V.
Published: March 2023

The optimal temperature regime for the synthesis of glass ceramics with YNbO4 : Tb3+ crystalline inclusions has been established. Glass ceramics were synthesized on the basis of a sodium borate matrix from oxide precursors. It has been established that synthesis at a temperature of 950oC is optimal, since at this temperature only one crystalline phase YNbO4 : Tb3+ is formed in the glass and its content is maximum. The spectra of crystalline inclusions and the glass matrix were obtained by the method of local cathodoluminescence, the phase composition of glass ceramics was studied by X-ray phase analysis. Keywords: YNbO4, luminescence, terbium ion, glass ceramics.
Features of the shape of the emission spectrum of a spherical microresonator with a high refractive index luminescent shell due to the polarization of the whispering gallery modes
Authors: Dukin A. A.  , Golubev V. G.
Published: March 2023

The effect of the thickness and refractive index of the shell on the amplitudes of lines of the TE and TM polarized whispering gallery modes (WGMs) in the emission spectrum of a microcavity structure consisting of a spherical core covered with a luminescent shell with a refractive index greater than that of the core is studied. The luminescence spectra of the shell, the radial distribution of the WGM field, and the mode parameters (wavelength, quality factor, and effective volume) are calculated using the method of spherical wave transfer matrices. It is shown that at certain subwavelength shell thicknesses, the amplitude of the TE mode emission peak is many times greater than the amplitude of the TM mode peak with the same polar, azimuthal, and radial indices. This is explained by the fact that with these parameters of the shell, WGMs propagate inside the shell as waveguide modes. Keywords: spherical microresonator, high refractive index luminescent shell, whispering gallery modes, mode polarization, amplitude of emission lines.
Effect of Laser Polarization on Photoionization Efficiency of Lutetium
Authors: D’yachkov A.B.  , Gorkunov A. A.  , Labozin A. V.  , Mironov S. M.  , Firsov V. A.  , Tsvetkov G. O.  , Panchenko V. Ya.
Published: March 2023

The effect of laser radiation polarization on the photoionization of lutetium is studied using three-stage scheme 5d6s2 2D3/2-5d6s6p 4Fo5/2-5d6s7s 4D3/2- (53375 cm-1)o1/2. It is shown that in a number of cases, there is a limitation of photoionization associated with the features of coherent photoexcitation. Keywords: laser selective photoionization, lutetium-177.
Localized excitons in ZnMnO
Authors: Sokolov V. I.  , Gruzdev N. B.  , Men`shenin V. V.  , Vokhmintsev A. S.  , Savchenko S. S.  , Weinstein I.A.  , Emelchenko G. A.
Published: March 2023

Lines a, b, c, d and impurity absorption edge of ZnMnO for sigma- and π-polarizations of light in temperature interval of 7-300 K were registered in this paper. Intensive lines aπ and asigma are clearly observed in interval of 7-100 K, while other lines are observed only at low temperatures. For determination of type of optical transitions, to which excitonic lines a, b, c, d are corresponding the calculation of oscillator strength of most intensive lines was made. Lines aπ and asigma have Lorentz form, parameters of this form were calculated with OriginPro 9.1 program. The energy of impurity absorption edge was determined. Lines a, b, c and d were analyzed in model of Mn2+-4O2- cluster. Optical transitions take place from antibonding (p+d5)*-states in forbidden gap to state, which is splitted from the bottom of conduction band of ZnMnO. Electron-hole pairs which are localized inside the cluster are called as local excitons. Keywords: zinc oxide, localized excitons, antibonding states.
Effect nanoparticles silicon carbide on the characteristics of solar cells based on lutetium diphthalocyanine
Authors: Rasmagin S.I.
Published: March 2023

Composites nanoparticles silicon carbide with lutetium diphthalocyanine were created. The size and shape nanoparticles silicon carbide, as well as their phase composition, were determined by electron microscopy. The absorption spectra of nanoparticles silicon carbide, a solution of lutetium diphthalocyanine, and a composite nanoparticles silicon carbide with lutetium diphthalocyanine were measured. Raman scattering spectra were obtained for nanoparticles silicon carbide. A comparative analysis of the absorption spectra of various samples was carried out. The effect of lutetium diphthalocyanine molecules on the optical properties nanoparticles silicon carbide was elucidated. The resulting composite of lutetium diphthalocyanine and nanoparticles silicon carbide was used as a sensitizer to create Gretzel cells. In the control Grotzel cell, lutetium diphthalocyanine was used as an absorber; in the working cell, lutetium diphthalocyanine was used in combination with nanoparticles silicon carbide. The open-circuit voltage and short-circuit current were measured under the same illumination of both Grotzel cells. Keywords: Solar photovoltaics, sensitizers, solar cells, silicon carbide, lutetium diphthalocyanine, semiconductor nanoparticles, Gretzel cells.
Entropy change at viscous flow of dispersive systems with a phase transition in their particles
Authors: Semikhina L. P.  , Shtykov S. V.
Published: March 2023

Based on the compensation effect, a method has been developed for the correct calculation of entropy changes at viscous flow of liquid dispersed systems using the Eyring equation. At temperature range of 313± 10 K in dispersed systems with a liquid-like state of dispersed phase particles the presence of a specific phase transition is substantiated, at which changes in enthalpy and entropy undergo a jump in these systems. Keywords: Eyring's equation, dispersed systems, phase transition.
Process of Change, Self-efficacy, Decisional Balance, and Stage Of Change of Physical Activity in Children: a Meta-analysis
Authors: Tie Yu , Tian Wen , Chen Yiru , Zang Guoqing , Shi Peng , Feng Xiaosu
Published: March 2023

Research findings on the application of the transtheoretical model (TTM) to physical activity in children and adolescents have been inconsistent, indicating that the relationships between structural elements in the TTM are unclear. We conducted a database search to collect TTM-based
cross-sectional studies and used a meta-analysis to explore the relationships between processes of change (POC), self-efficacy (SEI), decisional balance (DBL), and stages of change in children and adolescents. Meta-analysis results of 16 articles showed that physical activity stage changes
in children and adolescents were associated with POC, SEI, and DBL, and that POC, SEI, and DBL had distinct stage characteristics. Thus, POC, SEI, and DBL differ in the extent to which they play a role in adjacent stage transitions in the physical activity of children and adolescents. We recommend
that stage-matched intervention strategies be developed based on key elements of adjacent stage transitions.
Visionary Leadership and Employee Voice Behavior: Mediating Role Of Self-efficacy
Authors: Du Ming , Bao Zongke
Published: March 2023

Facilitating employee voice behavior has become an area of interest in the human resource management field, and many studies have examined the influence of leadership on employee voice behavior. However, there are limited studies on the relationship of visionary leadership to employee
voice behavior. We investigated the relationship between visionary leadership and employee voice behavior, as well as the mediating role of employee selfefficacy. Data were collected through a paper-and-pencil survey completed by 294 supervisor–subordinate dyads in China. Results of
structural equation modeling showed that visionary leadership was positively related to employee voice behavior and that this direct relationship was mediated by employee selfefficacy. This study is the first to empirically examine the relationships among visionary leadership, employee self-efficacy,
and employee voice behavior, and it provides a new path to link visionary leadership to employee voice behavior.
The Effects of Play-based Expression Activities Using Picture Books on Young Children’s Creativity
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Bae Seon Hui , Choi Sun Young
Published: March 2023

Objectives The purpose of this study is to investigate the effects of play-based expression activities using picture books on young children’s creativity. Methods The subjects of this study were 24 young children (12 experiment group in Root class and 12 control group in Sprout class) for three-year-olds in G kindergarten located in T city, Gyeongsangnam-do. The experiments was done 16 sessions during an 8 week period on the experiment group expression activities using picture books and on the control group did activites focusing on picture books. The pre- and post-test were conducted using the test tools for creativity was based on Independent samples t-test, corresponding samples t-test, and both Wilcoxon Rand sum test and Mann -Whitney U test as non-parametric test using the SPSS 25.0 program. Results First, expression activities using picture books had the positive effect on the creativity in terms of four sub-elements of creativity : dicergent thinking, curiosity, immersion/patience, denormality, independence. Conclusions Expression activites using picture books are effecitve educational ones having positive influences to promote young children’s creativity.
A Study on the Effects of Early Childhood Teachers' Mathematical Attitudes and Mathematical Knowledge for teaching on Mathematics Literacy Environment
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lim Kyung-Ryeong , Kim You-Jung
Published: March 2023

Objectives The purpose of this study is to analyze the effect of early childhood teachers' mathematical attitudes and Mathematical Knowledge for teaching on the mathematical literacy environment of early childhood education institutions. Methods Data were collected from 229 teachers working at 34 kindergartens and daycare centers located in Seoul, Gyeonggi, and Incheon using a questionnaire for teachers on mathematical attitudes, Mathematical Knowledge for teaching, and mathematics literacy environment. The collected data were analyzed using descriptive statistics, frequency analysis, t-test, one-way ANOVA, and stepwise multiple regression analysis. Results First, it was found that early childhood teachers differ in their mathematical attitudes according to the age of the class they are in charge of, and Mathematical Knowledge for teaching differs according to career, academic background, and type of institution among general variables of early childhood teachers. In addition, it was found that the environment of mathematical literacy differed according to career and educational background, type of institution, and age in charge among general variables of early childhood teachers. Second, general variables of early childhood teachers, mathematical attitudes and mathematical knowledge for teaching showed positive correlations with the environment of mathematics literacy. Third, the general variables of early childhood teachers, the motivation for mathematics in the mathematical attitude, and the knowledge of teaching and learning methods in the mathematical knowledge for teaching had explanatory power in the mathematical literacy environment. Conclusions This study investigated the effects of teachers' general variables, mathematical attitudes, and mathematical knowledge for teaching on the mathematical literacy environment of early childhood education institutions. Through this, it was emphasized that teacher education should be carried out by developing a teacher education program that can improve teachers' mathematical attitude and knowledge of mathematics and pedagogy as a way to improve the quality of the environment for mathematics literacy in the early childhood education field.
Comparative Analysis of the Guidelines for the Development of Subject Curriculum in the 2015 and 2022 Revision from the viewpoint of Coherence between General Guidelines and Subject Curriculum
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Han Hyechong
Published: March 2023

Objectives The purpose of this study is to draw implications for the next curriculum revision by comparing and analyzing the 2015 Revised Curriculum and the 2022 Revised Curriculum in terms of coherence between general guidelines and subject curriculum in Korea. Methods The focus of analysis is on the guidelines for the development of subject curriculum of 2015 Revised Curriculum and 2022 Revised Curriculum. In particular, in the case of judgment on clarity, in addition to judgment on whether or not to present, it was analyzed with a focus on whether the guideline itself was sufficient to develop the subject curriculum without any more explanation from the standpoint of the subject curriculum development team. Results Although the problem of the 2015 revision guidelines that did not provide guidance on the meaning of competency education, curriculum design principles, and national and social requirements was resolved, it is found that the 2022 revision guidelines for development of subject curriculum are still insufficient in preparing guidelines considering the characteristics of each subject and guidance on development of achievement standards as performance standards. Conclusions Based on the results of this analysis, suggestions for the next curriculum revision are presented as follows. First, it is necessary to prepare clear directions and development guidelines related to the development of achievement standards. Second, it is necessary to prepare guidelines for developing subject curriculum in consideration of the characteristics of each subject. Third, Detailed discussions on how to reflect national and social requirements are needed. As a follow-up study, it is necessary to restructure the overall structure of the subject curriculum in connection with the general direction of core competency education.
Developing a Parents-Children involved Group Counseling Program Using U&I to Improve Learning Strategy for Middle School Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Um Giran , Cho Yongsun
Published: March 2023

Objectives The purpose of this study was to devise a parent-child-linked group counseling program using U&I to improve learning strategies for middle school students, and to verify the effectiveness of the program. Methods The program design was devised through the procedure of analysis → design → development → execution → evaluation according to the procedure of the ADDIE model, which is a program development model. Next, the program was applied to the experimental group and compared with the control group to analyze the effect. For the analysis of program effects, a learning strategy measurement tool developed by Kim Dong-il (2005) was used. Results First, for program planning, the direction of program planning was set through a request survey and a review of previous studies. Then, the purpose and goal of the program were set. Next, the goal of each session of the program, the contents of the activity, and the operation strategy of the program were devised, and the final program was completed through the validation process from experts. As a result of applying the program to the experimental group, the overall score of the learning strategy of the experimental group and the score of all sub-factors were significantly higher than that of the control group. In addition, as a result of the interview analysis of children and parents, it was confirmed that children were able to establish and implement a learning strategy suitable for themselves through self-understanding, and parents were able to identify their children's learning strategy and link it to positive learning support. Conclusions As a result of applying the program to the experimental group, the overall score of the learning strategy of the experimental group and the score of all sub-factors were significantly higher than that of the control group. In addition, as a result of the interview analysis of children and parents, it was confirmed that children were able to establish and implement a learning strategy suitable for themselves through self-understanding, and parents were able to identify their children's learning strategy and link it to positive learning support.
Analysis of 6th graders' understanding of the area of the circle
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Im HunTaek , Ko Eun-Sung
Published: March 2023

Objectives In this study, the degree of understanding of the concept of measuring the area of the circle of 6th graders in elementary school was analyzed. Methods In this study, the concept of measuring the area of the circle was divided into approximate, unit repetition, rearrangement, and arrangement structure, and based on this, a task was developed for sixth-grade students. We applied the task and analyzed the response to knowing that the meaning of the area of the circle is the number of units, using strategies (approximation, strength) to find the area of the circle, and whether it can be divided and rearranged appropriately. Results Students did not properly understand the meaning and measurement concept of the area of the circle. There were many students who did not recognize the area of the circle as the number of units, and their understanding of rearrangement and arrangement structure was more insufficient than their understanding of other measurement concepts. In addition, there was a lack of understanding of the spirit that reflected the curve. Conclusions When guiding the area of a circle, it is important to guide it to understand it from the perspective of measurement, to find ways to supplement students' incomplete understanding of the unit concept, and to be given the experience of dividing and rearranging circles directly. Based on this, implications for the direction of the circle's width map and the development of the next textbook were derived.
The mediating effect of learned helplessness in the workplace bullying bystander and pro-bullying between the just world beliefs
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yang Kyudon , Jo Hanik
Published: March 2023

Objectives This study examined the mediating effects of learned helplessness in relationship among the just world beliefs, workplace bystander and workplace pro-bullying. Methods For this purpose, an online survey was conducted on 308 male and female workers aged 20 to 60 across the country who witnessed workplace bullying. Based on the collected data, descriptive statistics and correlation analysis were performed. In addition, multiple regression analysis was performed to examine the mediating effect of learned helplessness and just world beliefs, and bystander behavior and pro-bullying bystanders in workplace harassment, and significance of mediating effects was verified through the Sobel test. Results There was a significant negative correlation between the just world beliefs and learned helplessness and there were significant positive correlations among the just world beliefs, learned helplessness, and pro-bullying behavior. There was a significant partial mediating effect of learned helplessness when the just world belief of people around workplace bullying leads to pro-bullying behavior, but no significant mediating effect was derived of learned helplessness between the just world beliefs and bystander behavior. Conclusions The results of this study are interpreted to show that the just world beliefs and learned helplessness are important variables in the workplace bystander that trigger pro-bullying behavior in the bystander. Limitations of this study and suggestions for further studies were discussed.
Análisis de la oferta académica ofrecida por universidades públicas y privadas en Costa Rica para la carrera de Preescolar y su relación con la formación docente entre los años 2020 y 2021
Authors: Calvo-Achoy Mayte , Sanabria-Hernández Marcela
Published: March 2023

En el presente artículo se plantean los resultados de la investigación que desarrolló la Cátedra de Psicopedagogía de la Universidad Estatal a Distancia (UNED) entre los años 2020 y 2021, cuyo objetivo fue analizar la oferta curricular que ofrecen tanto las universidades públicas como las privadas del país, en lo que respecta a la formación de profesionales de educación preescolar. En un primer momento, el artículo describe brevemente los hitos históricos que han marcado huella en la educación preescolar y, posteriormente, se hace una reflexión teórica sobre el perfil docente y la importancia de esta formación en la atención integral de niños y niñas. A nivel metodológico, la investigación se enmarca en un enfoque cualitativo que incorpora el análisis de la información, es decir, se establecen objetivos y criterios para revisar los datos, que a la postre brinden insumos que permitan su interpretación y análisis. Los resultados evidencian semejanzas y diferencias en la oferta curricular, así como los contenidos que debieran ser considerados para una atención integral hacia la población de la primera infancia y que no están presentes en los programas. A manera de conclusión, se evidencia la necesidad de ejecutar acciones de mejora en el área curricular, administrativa y de ingreso a las carreras, así como mejorar la coordinación entre diferentes instancias públicas y privadas que permitan una formación de calidad de las personas profesionales de la educación preescolar. Se espera que los resultados y las conclusiones de esta investigación sirvan de sustento para otros estudios y sean considerados en los ejercicios de diseño, rediseño y acreditación de las carreras de educación preescolar en el país.
Uso de probióticos do gênero dos lactobacillus e seus eventos adversos em pacientes críticos
Authors:   , Amâncio, Amanda Karen Amâncio, Amanda Karen , Rodrigues, Ana Laura de Andrade Rodrigues, Ana Laura de Andrade
Published: March 2023

A microbiota intestinal é constituída por uma variedade de microrganismos vivos que colonizam grande parte de sua extensão e estabelecem uma relação de simbiose com seu hospedeiro, promovendo um papel importante para a saúde humana ao auxiliar na digestão e absorção de nutrientes, produção de vitaminas e redução de agentes patogênicos através da exclusão competitiva. Disbiose é caracterizada como um desequilíbrio destes microrganismos benéficos, levando a um aumento de microrganismos nocivos. Nos últimos anos, o surgimento de produtos funcionais, que além de suas funções nutricionais, podem modular os processos metabólicos. Dentre estes produtos funcionais, podemos destacar os probióticos, que são microrganismos vivos que, quando administrados em doses adequadas, conferem benefícios para a saúde do hospedeiro. Um dos gêneros de microrganismos mais proeminente para este fim é o Lactobacillus, que possui a capacidade de melhorar a função da barreira gastrointestinal. Sua segurança se baseia no seu histórico de uso em alimentos por séculos e estudos em populações saudáveis, contudo, é sugerido que a segurança dos probióticos não é bem elucidada pela maioria dos estudos publicados. O uso de probióticos em pacientes críticos tem sido associado a um maior risco de infecção e/ou morbidade. Neste estudo foi realizada uma revisão da literatura sobre o uso de probiótico do gênero dos Lactobacillus em pacientes críticos para observar a prevalência de efeitos adversos nesta população. Dentre 35 artigos encontrados, 8 foram selecionados para esta revisão. Após análise dos dados, apenas 1 estudo apontou a presença de eventos adversos e eventos adversos graves, enquanto 5 autores não observaram eventos adversos ou não citaram a presença de eventos adversos.
Combination of transcatheter arterial chemoembolization and anti-PD-L1 liposomes therapy suppressed hepatocellular carcinoma progression in mice
Authors: Li Jie , Zhang Lijuan , Tao Yun , Sun Zongqiong , Ge Yuxi , Hu Shudong
Published: March 2023

Background To study the effects of combination TACE and anti-PD-L1
liposome drug in treating HCC in mice models. Methods We constructed the
liposome drug with lecithin and cholesterol and mannitol, etc. Besides,
the HCC mice model was established through abdominal subcutaneous
injection HepG2 cancer cells in SD mice, then the PE-10 polyethylene
catheter was used for TACE therapy. The SD mice were separately received
TACE treatment, avelumab liposome drug therapy, and TACE combined with
avelumab liposome drug therapy. Results The liposomes drug was
successfully constructed with a diameter of 125.5 nm. After the mice
received TACE and (or) immunotherapy, the combined liposome drug therapy
significantly reduced the volume of hepatic carcinoma tissues, besides,
the apoptotic rates of hepatic carcinoma cells in the combined liposome
drug treatment group was increased obiviously compared with other
groups. Moreover, the protein TGFβR2 located in the cellular membrane
was obiviously down-regulated in the combined liposome drug therapy,
whilst, the expression of SMAD7 and PTPN14 was up-regulated in the
treatment groups compared with the mice without treatment, besides, the
protein PTPN14 was mainly located in the nucleus. Additionally, the mRNA
expression of genes SNAI1 and Vimentin was significantly down-regulated
in the combined liposome drug therapy. Conclusion Combination of
transcatheter arterial chemoembolization and anti-PD-L1 liposome drug
therapy significantly suppressed hepatocellular carcinoma proliferation
and metastasis in mice models.
On No-Man Land: Perspectives from healthcare professionals on the impact of loneliness on dissociation as a coping mechanism
Authors: Agaiby Mirit
Published: March 2023

Background: Loneliness is a “hallmark” of dissociative
disorders (DD), but its impact on DD patients is understudied in the
field. Similarly, therapeutic modalities best suited for DD patients is
an area of controversy; with research advocating cognitive therapies
(CTs) despite the risk of retriggering trauma in patients.
Research objectives: 1. To explore if dissociative episodes or
phases are triggered in individuals as a result of loneliness, using
mental healthcare professionals’ experiences in treating such patients.
2. To discuss participants’ recommended therapeutic techniques for DD
patients experiencing loneliness. Method: Using a qualitative
design, fourteen trauma and dissociation practitioners were interviewed
with semi-structured questions, and a coded thematic analysis was
conducted to extract codes, sub-themes, and themes from the data.
Results: The findings show a two-way, yet non-linear
relationship between loneliness as a trigger and the use of dissociation
to cope with it. Participants strongly advocated the use of trauma-based
modalities such as EMDR. Discussion and Conclusion: The severer
the trauma and the less effective the patients’ coping mechanisms are,
the severer their dissociation is, and their inability to connect to
their own selves, and in turn, to others, which causes them to seek
isolation. However, supportive, healthy networks, when patients
seek/have them, contribute significantly to developing a sense of
safety, which allows DD patients to feel more grounded in their outer
realities and allows them to lead more satisfying lives. Practitioners
agreed that safe therapeutic alliances are pivotal for patients; it
allows them to connect more to their therapists, and subsequently to
their social networks. Furthermore, all practitioners advocated moving
away from using extensive CTs with DD patients in the initial phase of
grounding and moving towards trauma-based and psychodynamic-based
modalities. Recommendations: For future research, it is
recommended that this link be studied by interviewing DD patients
themselves, and/or conducted using quantitative designs to raise
test-retest reliability.
Certain weighted young and Pólya-Szegö-type inequalities involving Marichev-Saigo-Maeda fractional integral operators with applications
Authors: Yang Wengui
Published: March 2023

In this paper, we establishes certain new weighted Young and
P?lya-Szeg?-type inequalities involving Marichev-Saigo-Maeda fractional
integral operators. Meanwhile, corresponding weighted Cauchy-Schwarz type
inequalities, Shisha-Mond type inequalities and Diaz-Metcalf type
inequalities for Marichev-Saigo-Maeda fractional integral operators are also
obtained. As applications, some estimates for weighted Chebyshev-type
inequalities with two unknown functions for Marichev-Saigo-Maeda fractional
integral operators are presented. The main results of this paper are more
general and include a great number of existing classical inequalities.
Nat Turner’s Rebellion: A Chronicle of Major Events
Authors: Шумаков А.А.
Published: March 2023

Восстание Ната Тернера, произошедшее в августе 1831 года в округе Саутгемптон, штат Вирджиния, является одним из самых знаковых и в то же время хорошо изученных и задокументированных событий американской истории. Тем не менее, можно с уверенностью утверждать, что в отечественной американистике должного внимания ему никогда не уделялось. До настоящего времени не вышло ни одного масштабного исследования. Даже сам ход восстания в русскоязычной литературе описан крайне поверхностно и, в основном, в публицистических работах, являющихся в большинстве своем переводом или компиляцией нескольких американских журналистских материалов. В данной статье автор попытался восполнить указанный пробел и восстановить общую картину и хронику событий, опираясь на источники и работы ведущих зарубежных специалистов по направлению «Афроамериканская история» (Black History) ⁎ . В статье подробно прослеживается маршрут продвижения группы мятежников по округу Саутгемптон и основные события, происходившие в активной фазе восстания, т.е. в период с 22 часов 21 августа до 5 часов утра 23 августа 1831 г. При этом вопросы выявления причин и предпосылок, а также непосредственной подготовки восстания автор намеренно опускает, фокусируясь исключительно на описании хода вооруженного выступления рабов. Автором предложена собственная периодизация восстания, а также определен круг причин его поражения.

Nat Turner’s Rebellion that took place in Southampton County, Virginia, in August 1831 is one of the most iconic and at the same time well-studied and documented events in American history. Nevertheless, it is safe to say that Russian American studies have never paid due attention to this issue. Not a single major study has been published so far. Even the course of the rebellion is described in Russian-language literature in a superficial manner mainly in popular science and journalistic works, which are mostly translations or compilations of several American journalistic materials. In this article, the author tried to fill this gap and to reconstruct the overall picture and chronicle of events, relying on the sources and works of leading foreign experts in the field of African American History (Black History).⁎ The article retraces in detail the advance of the rebel group through Southampton County and the main events that took place in the active phase of the rebellion, i.e. in the period between 10 p.m. on August 21 and 5 a.m. on August 23, 1831. The author deliberately omits the questions of identifying the causes and prerequisites of the rebellion as well as its immediate preparation, focusing exclusively on the description of the course of the armed slave uprising. The author proposes his own periodization of the rebellion and also determines the range of reasons for its defeat.
Vologda Merchant Gavriil (Gavrila) Fetiev: An Experiment of Personal Archaeography (About the Book by Marina Cherkasova) Review of Kupets G.M. Fetiev: issledovanie i arkhiv [Merchant G.M. Fetiev: Research and Archive] by M.S. Cherkasova (Vologda: Drevnosti Severa, 2020)
Authors: Всеволодов А.В.
Published: March 2023

Рецензируемое исследование представляет собой первый опыт систематического изложения биографии крупнейшего вологодского купца XVII столетия Г.М. Фетиева, а также сводной публикации документальных материалов, связанных с его торговой и служебной деятельностью. Оно подводит итог почти двадцати лет работы автора – видного российского медиевиста, доктора исторических наук М.С. Черкасовой.

The study under review is the first attempt of a systematic presentation of Gavriil (Gavrila) Fetiev’s biography, the largest Vologda merchant of the 17th century and a consolidated publication of documentary materials related to his trading and official activities. It summarizes almost twenty years of work of the author, Doctor of Historical Sciences, prominent Russian medievalist Marina S. Cherkasova.
Dialysis specialist care and patient survival in hemodialysis facilities: a Korean nationwide cohort study
Authors: Park Hayne Cho , Kim Do Hyoung , Cho Ajin , Kwon Young Eun , Ryu Dong-Ryeol , Kim Jinseog , Yang Ki Hwa , Shin Ji Hyeon , Son Eun Jung , Lee Young-Ki
Published: March 2023

Background: It is important for the dialysis specialist to provide essential and safe care to hemodialysis (HD) patients. However, little is known about the actual effect of dialysis specialist care on the survival of HD patients. We therefore investigated the influence of dialysis specialist care on patient mortality in a nationwide Korean dialysis cohort.Methods: We used an HD quality assessment and National Health Insurance Service claims data from October to December 2015. A total of 34,408 patients were divided into two groups according to the proportion of dialysis specialists in their HD unit, as follows: 0%, no dialysis specialist care group, and ≥50%, dialysis specialist care group. We analyzed the mortality risk of these groups using the Cox proportional hazards model after matching propensity scores. Results: After propensity score matching, 18,344 patients were enrolled. The ratio of patients from the groups with and without dialysis specialist care was 86.7% to 13.3%. The dialysis specialist care group showed a shorter dialysis vintage, higher levels of hemoglobin, higher single-pool Kt/V values, lower levels of phosphorus, and lower systolic and diastolic blood pressures than the no dialysis specialist care group. After adjusting demographic and clinical parameters, the absence of dialysis specialist care was a significant independent risk factor for all-cause mortality (hazard ratio, 1.10; 95% confidence interval, 1.03–1.18; p = 0.004).Conclusion: Dialysis specialist care is an important determinant of overall patient survival among HD patients. Appropriate care given by dialysis specialists may improve clinical outcomes of patients undergoing HD.