bluuebunny/crossref_metadata_2025 huggingface dataset:
Modifikasi Concentrated Yogurt Susu Kambing Dengan Penambahan Tepung Porang (Amorphophallus oncophyllus) ditinjau dari Persentase Produk, Whey Bebas, Sineresis, dan pH
Authors: Prayitno Salvian Setyo , Maharani Nadia , Rusti Nanda
Published: May 2023

Penelitian ini bertujuan untuk mempelajari peningkatan kualitas concentrated yogurt susu kambing yang dimodifikasi dengan tepung porang. Kualitas concentrated yogurt yang diamati meliputi persentase produk (yield), whey bebas, sineresis, dan pH. Materi yang digunakan yaitu susu kambing Peranakan Etawah (PE), kultur starter yogurt komersial, dan tepung umbi porang (dibuat sendiri). Rancangan percobaan yang digunakan adalah rancangan acak lengkap (RAL) dengan 4 perlakuan dan 5 ulangan. Perlakuan terdiri atas kontrol yaitu tanpa penambahan tepung porang (P0), penambahan tepung porang 0,5% (w/w)(P1), tepung porang 1% (w/w)(P2), dan tepung porang 1,5% (w/w)(P3). Susu difermentasi menjadi yogurt selama 5 jam pada inkubator (42°C), sebelum disaring menjadi concentrated yogurt. Parameter concentrated yogurt yang diuji berupa persentase yield, whey bebas, sineresis, dan pH yang diukur setelah yogurt disaring selama 24 jam pada refrigerator (10°C). Hasil penelitian menunjukan bahwa tepung porang secara nyata (P<0,05%) menyebabkan peningkatan persentase yield dan pH concentrated yogurt, sedangkan whey bebas dan sineresis mengalami penurunan. Penambahan tepung porang 1,5% (P3) pada pembuatan concentrated yogurt menghasilkan persentase yield, whey bebas, sineresis, dan pH terbaik dibandingkan perlakuan lainnya. Berdasarkan hasil penelitian dapat disimpulkan bahwa kualitas concentrated yogurt meningkat secara nyata dengan dimodifikasi penambahan tepung porang. Manfaat penelitian ini adalah memberikan informasi penggunaan tepung porang ternyata dapat meningkatkan kualitas concentrated yogurt susu kambing.
Development of a Mobile Application for Grid - Tied Solar Photovoltaic (PV) System Design for Residential Buildings
Authors: ABDELSALAM YOUSIF MOHAMEDELAMEN ELTEGANI
Published: May 2023

As digital technology is continually evolving and an increasing number of people from diverse backgrounds are spending more time on their mobile phones, building a mobile app for solar PV system design is beneficial for homeowners who wish to invest in solar energy as an alternative source of power for their appliances. The study aimed to develop a smartphone app for integrating solar photovoltaic systems in existing and new residential buildings. The software provides design on the rated capacity of the photovoltaic array, the size of the tie-inverter, the overall cost of the photovoltaic system, yearly savings, and return on investment. The software was created using solar radiance data, net-metering, and local government permitting requirements. The researcher collected 12 months of solar radiance data from five Dagupan City households before developing the app's design guidelines. The developed smartphone app was tested on residences with existing solar PV systems and compared to the real parameters of current solar PV systems. The results showed that the mobile app is a dependable tool for supporting residential clients in identifying suitable solar system sizes for their homes.
Rain Process Education as Interactive Multimedia in Early Childhood using the Multimedia Development Life Cycle (MDLC)
Authors: Nur Yohani Setiya Rafika , Aldo Dasril , Utami Annisaa
Published: May 2023

Learning media has a positive impact because it can be fun, increase students' interest in learning, and be interactive. The learning method in Early Childhood Education (PAUD) Ratnanigsih uses a Sentra approach and the environment by playing sambal learning to develop the intelligence of a potential child. The facts in PAUD Ratnaningsih found obstacles in the teaching and learning process. These obstacles occur due to the lack of visualization or media for teachers, and the absence of variations in learning can cause saturation in children. Users in this study are early childhood teachers in PAUD Ratnaningsih. Based on these problems, a learning press is needed for teacher and child relations educated at PAUD Ratnaningsih. The learning media design method in this study uses the Multimedia Development Life Cycle (MDLC) approach and learning media using Macromedia Flash 8. The results of this study are in the form of storyboard design, visualization of interface design, implementation of learning media, and testing with Blackbox Testing. Based on the conclusions of this study shows that all components and features of learning media function properly and can be used by teachers in the learning process "Universe" with the sub-theme "Rain".
PENGARUH VARIASI SURFAKTAN TERHADAP SIFAT FISIK SAMPO BERBASIS MINYAK SERAI WANGI (Cymbopogon nardus (L.) Rendle) DAN EKSTRAK LIDAH BUAYA (Aloe vera)
Authors: Nareswari Tantri Liris , Nurjannah Okta , Sari Lusi Meliyana Nur Indah , Syafitri Erga
Published: May 2023

Sampo merupakan salah satu sediaan kosmetik yang digunakan untuk keramas sehingga membuat rambut menjadi bersih dan mudah untuk diatur. Sediaan sampo terdiri dari berbagai komponen, dengan surfaktan merupakan kunci dari pembersihan rambut karena memiliki struktur molekul yang terdiri dari bagian hidrofilik dan lipofilik dengan kemampuan menurunkan tegangan permukaan antara air dan kotoran sehingga tersuspensi dalam fase air. Penelitian ini dilakukan untuk melihat pengaruh variasi sodium lauril sulfat (SLS) terhadap karakteristik sifat fisik sampo cair (organoleptik, pH, viskositas, dan bobot jenis). Sampo dibuat dengan metode emulsifikasi menggunakan minyak serai wangi (Cymbopogon nardus (L.) Rendle) dan ekstrak lidah buaya (Aloe vera) sebagai zat aktif. Pada awal formulasi, HPMC dikembangkan terlebih dahulu kemudian dicampurkan dengan fase air lain (berupa SLS, aloe vera, cocomide DEA, propil paraben, metil paraben, mentol, akuades). Fase air dan fase minyak (minyak serai wangi) dipanaskan pada suhu masing-masing 60-70˚C kemudian dicampurkan dicampurkan dengan magnetic stirrer pada kecepatan 800 rpm selama 15 menit. Hasil penelitian menunjukkan SLS berpengaruh signifikan (p<0,05) terhadap peningkatan pH, viskositas, dan bobot jenis dari sampo. Korelasi Pearson pada konsentrasi SLS terhadap pH yaitu R=0,926; terhadap viskositas yaitu R=0,973; sedangkan terhadap bobot jenis yaitu R=0,918. Kesimpulan dari penelitian ini adalah SLS berpengaruh besar pada peningkatan pH, viskositas, dan bobot jenis sediaan sampo berbasis minyak serai wangi dan ekstrak lidah buaya.
Dukungan Keluarga terhadap Pengendalian Hipertensi pada Lansia di Wilayah Rw 10 Kelurahan Utan Panjang Jakarta Pusat
Authors: Kurwiyah Neneng , Anwar Syamsul , Herlinah Lily , Suharsiwi Suharsiwi , Annantusia Annantusia , Pangerstu Shania Desi
Published: May 2023

ABSTRAK Fokus utama pelayanan keperawatan/kesehatan masyarakat lebih ditekankan pada upaya promotive dan preventif agar para lansia mampu menolong dirinya sendiri dibidang kesehatan sesuai dengan kebutuhan dan masalah kesehatan yang seringkali dialaminya, oleh karenanya pengetahuan keluarga dengan lansia mengenai upaya kesehatan perlu menjadi perhatian. Tujuan penelitian ini yaitu meningkatan pengetahuan keluarga dengan lansia mengenai posyandu lansia dan meningkatkan kemampuan keluarga dengan masyarakat lansia khususnya dalam mengenali dan mengatasi permasalahan kesehatan yang dihadapi. Metode yang digunakan yaitu  tahapan-tahapan yang akan dilakukan mulai dari membangun kemitraan, menyiapkan bahan/alat yang akan digunakan, melakukan promosi/pendidikan kesehatan kepada keluarga dengan kelompok lansia, pembentukan/pengaktifan posyandu lansia, serta pengorganisasian kelompok keluarga lansia diwilayah binaan. Hasil penelitian ini yaitu dari kuesioner pre dan posttest didapatkan hasil terjadi peningkatan pengetahuan lansia setelah dilakukan kegiatan penyuluhan sebesar 78% dan dukungan keluarga sebesar 75%. Kata Kunci: Dukungan Keluarga, Pengendalian Hipertensi, Lansia  ABSTRACT The main focus of public health services is more emphasis on promotive and preventive efforts so that the elderly are able to help themselves in the health sector according to their needs and health problems that they often experience, by providing knowledge to families and the elderly regarding health efforts that need to be a concern. The purpose of this research is to increase the knowledge of families with the elderly regarding the elderly Posyandu and to improve the ability of families and the elderly, especially in recognizing and dealing with health problems they face. The method used is the stages that will be carried out starting from building partnerships, preparing materials/tools to be used, conducting health promotion/education for families with elderly groups, forming/ activating elderly Posyandu, and organizing groups of elderly families in the target area. The results of this study, namely from the pre and posttest questionnaires, showed that there was an increase in the knowledge of the elderly after counseling activities by 78% and family support by 75%. Keywords: Family Support, Hypertension Control, Elderly
ЗНИЩЕННЯ ЄВРЕЙСЬКОГО НАСЕЛЕННЯ В КАЛІНІНДОРФСЬКОМУ ЄВРЕЙСЬКОМУ НАЦІОНАЛЬНОМУ РАЙОНІ ВОСЕНИ 1941 р.
Authors: Круглов Олександр
Published: May 2023

Нижченаведені документи, більшість яких публікуються вперше, у своїй сукупності створюють більш-менш повну і цілісну картину того, що відбувалося в Калініндорфському районі восени 1941 р., розкривають механізм масових вбивств євреїв, а також міру участі в цих вбивствах старост і поліцейських з числа місцевого населення. У 1944–1947 рр. та в 1952 р. щонайменше 37 таких осіб було виявлено радянськими органами безпеки та засуджено: частину – до смертної кари, частину – до різних строків каторжних робіт . З членів Sonderkommando 10а, які вчинили розстріли євреїв, ніхто до відповідальності за ці вбивства не був притягнутий, до того ж прокуратура Мюнхена, яка свого часу розслідувала злочини, вчинені цією командою, не мала жодної інформації про акції в цьому районі.
Analysis and solution strategies of the early retirement trend of teachers in Malaysia
Authors: Zhao Na , Li Han
Published: May 2023

This study examines the trend of early retirement among teachers in Malaysia. The paper investigates the underlying influencing factors, the implications of the issue, proposes five realistic solutions, and provides a preventive mechanism from an organizational management perspective. The study employed a combination of keyword search and literature review to gather relevant information. The findings suggest that teachers in Malaysia are leaving early due to factors such as excessive workload, health-related issues, family responsibilities, lack of job advancement opportunities, and employment opportunities outside the education sector. The implications of early retirement are far-reaching, including increased workload for remaining teachers, loss of institutional knowledge, and cost of replacing experienced teachers. This paper proposes five realistic solutions, including providing opportunities for career advancement, reducing workload, improving health and safety measures, promoting work-life balance, and offering better compensation and benefits. The preventive mechanism from an organizational management perspective suggests the importance of creating a positive work environment, fostering open communication, providing professional development opportunities, and supporting teachers in their personal and professional lives.
Responses of Lotus pedunculatus to sulphur fertiliser and defioliation regime in acid soils at low temperature
Authors: Stevens David , Casey Marie , Bennett Charlie , Thompson Bryan , Garden Nick , Garden Pat
Published: May 2023

The potential for Lotus pedunculatus is greatest in acid soils on hill and high country, but requires establishment success, nutrient supply and grazing management. This work investigated the role of sulphur fertiliser and the influence of defoliation regime on production of Lotus in low pH, high aluminium soils. Yields measured in year one were positively related to soil sulphate but not phosphorus. Sulphur, applied at two sites (low or high productivity) at 0, 24 or 78 kg S/ha, failed to alter yield over three years. The site, at 1000 m a.s.l., had base vegetation of unimproved tussock, low soil pH and P (4.8 and 7 respectively) and high Al (30-40 ppm). Yields ranged between 1900 and 3200 kg DM/ha/annum and was reduced when initial plant numbers were lower. Lotus contributed 65- 85% of the herbage for grazing (excluding tussocks). Yields were maximised by defoliation to 2 cm height each season or once in autumn. Establishing high plant numbers increased productivity. Single, late season grazing promoted rhizome development and resulted in the highest yields by year 3. Grazing to 2 or 5 cm residual once a season produced similar herbage, but lower rhizome development.
Justice-involved girls and me
Authors: Peng Lance
Published: May 2023

This presentation was delivered at the work-in-progress meeting of the Cambridge Educational Dialogue Research Group on May 2, 2023. It focused on ongoing research for my PhD thesis which employed an interpretative phenomenological framework and creative methods to investigate the gender identity of justice-involved adolescent girls in the context of education within out-of-home placements. The session featured insights gained from recent fieldwork and data collection expeditions. It was designed to offer an informed perspective and critical reflections. During the presentation, the hauntological approach in research was introduced to provide a deeper understanding of the ethical and practical implications of redirecting research focus mid-way through fieldwork. This was illustrated with relevant examples to enhance the audience's comprehension of the complexities involved in qualitative research and the importance of ethical considerations in research design.
Peningkatan Value Usaha Mikro Kecil Menengah (UMKM) di Kabupaten Pasuruan Melalui Kesadaran Taat Pajak
Authors: Lazuardi Yanuar , Rakhmayani Anis Nur
Published: May 2023

Meningkatnya belanja pemerintah pusat dan pemerintahan daerah menyebabkan meningkatnya pengeluaran pemerintah dari tahun ke tahun. Hal ini mendorong pemerintah meningkatkan jumlah penerimaan Negara, salah satunya penerimaan dari sektor pajak. Pajak sebagai sumber pendapatan terbesar penerimaan Negara diharapkan mampu menutupi pengeluaran-pengeluaran Negara agar terwujud APBN yang mandiri, seimbang dan dinamis sesuai tujuan pembangunan nasional. Untuk mewujudkan kondisi tersebut langkah yang dilakukan pemerintah dengan melakukan perubahan mendasar pada peraturan perpajakan atau Tax Reform. Perubahan tersebut tentunya berdampak pada Usaha Mikro Kecil Menengah sebagai subjek pajak dalam negeri. Tidak dapat dipungkiri, banyak diantara pelaku Usaha Mikro Kecil Menengah di Indonesia kurang memahami secara utuh peraturan perpajakan yang ada, selain itu  mindset pajak merupakan unsur yang dapat mengurangi perolehan keuntungan, dapat dipahami jika Wajib Pajak berusaha membayar pajaknya dengan efektif dan efisien mungkin dalam rangka optimalisasi manajemen laba, akan tetapi hal tersebut harusnya tetap dilakukan dalam bingkai peraturan yang ada. Oleh karena sistem perpajakan di Indonesia menganut Self Assesment maka kepatuhan pajak menjadi unsur yang penting untuk diperhatikan, kesalahan dalam menghitung, membayar dan melaporkan kewajiban perpajakan berakibat timbulnya sanksi perpajakan. Tidak jarang Usaha Mikro Kecil Menengah gulungtikar dalam sekejap karena sanksi perpajakan yang didapat tidak dapat dilunasinya.
Pendampingan Pengenalan BEI pada Sekolan Menengah Kejuruan
Authors: Setiadi Arvieka Sabilla Putri , Setianingsih Novie Astuti
Published: May 2023

Generasi muda ini perlu dikenalkan dengan hal-hal yang positif dan bermanfaat bagi kemajuan negara. Salah satunya adalah pengenalan saham pada Bursa Efek Indonesia (BEI). Metode pembelajarannya adalah: 1. Metode Ceramah; 2. Metode Diskusi; 3. Metode Tanya jawab; 4. Metode demonstrasi. Program PKM ini memberikan dampak yang positif dan peningkatan pengetahuan tentang saham di pasar modal pada mitra. Peningkatan yang dimaksud adalah peningkatan pengetahuan yang semula belum tahu dan belum paham apa itu saham di pasar modal, kemudian setelah kegiatan PKM ini mitra mengetahui, memahami dan bisa melakukan trading saham sendiri sehingga bisa memperoleh return dari jual beli saham tersebut.
Diseminasi Mesin Penggiling Pada Home Industry Sambel Pecel Dapoer Wima Kediri
Authors: Wahyu Mujahid , Hendarti Devina Rosa , Wibowo Alvalo Toto , Setiawan Deny , Cahyono Hiding
Published: May 2023

Sambal pecel merupakan salah satu produk makanan khas nusantara. Home industry Dapoer Wima termasuk salah satu produsen makanan khas tersebut yang berasal dari Kediri. Kebutuhan pasar yang menjanjikan, namun di home industry tersebut belum didukung oleh peralatan produksi yang memadai. Proses penggilingan sambel pecel dilakukan di luar area produksi sehingga tidak efisien serta tidak terjaminnya higienitas produk. Tujuan dari program ini adalah untuk mendesiminasikan mesin penggiling pada home industry Sambel Pecel Dapoer Wima sehingga lebih efektif dan higienis produknya. Metode pelaksanaan program meliputi pengumpulan data, pembuatan desain mesin, perhitungan perancangan mesin, manufaktur mesin, pengujian mesin, dan bimbingan teknis pengoperasian serta penyerahan mesin ke pengguna. Hasil program yaitu mesin penggiling sambel pecel berkapasitas 10 kg/jam dengan sepesifikasi penggerak berupa motor listrik AC 1 phasa berdaya 0,5 hp, menggunakan transmisi berjenis pulley berdiamater 7,62 cm dan 25,4 cm  dan v-belt tipe A, penggiling menggunakan screw conveyor dengan kapasitas pemindah 0,0257 m3/menit, dan material rangka menggunakan besi siku.
Application of Blockchain Technology at Sekolah Islam Terpadu Al-Madinah
Authors: Mohammad Kahfi Abdul Azis  , Dewi Wahyuningsih  , Patras Yuyun Elizabeth Patras
Published: May 2023

Abstract: The purpose of this study is to discuss Blockchain Technology and the application of Sisko at the Al-Madinah Integrated Islamic School, where the students’ cognitive development varies from 4 years to 17 years old. This article uses the library research method which refers to 19 articles downloaded from Google Scholar and Crossref. Blockchain technology is a system that limits its users according to its boundaries but can still be connected with other users. One of the systems for implementing Blockchain Technology at the Sekolah Islam Terpadu Al-Madinah is Sisko SIT Al-Madinah, which contains a database about education from Kindergarten to High School within the Al-Madinah Integrated Islamic School. The menu in the Sisko system is different for each user, for example students use Sisko for exams and assignments, teachers use Sisko to input grades and savings, principals and vice principals use Sisko to manage curriculum, add and edit student data, map students into classes, and finally the Sisko admin uses it to add and edit report formats, map user accounts and archive school databases. Sisko is highly recommended for schools that want to be more effective and efficient in managing data, finances, learning outcomes and in archiving all of their data because schools must be ready to shift into school digitalization in this era.
Integrated multi-trophic aquaculture with sugar kelp and oysters in a shallow coastal salt pond and open estuary site
Authors: Green-Gavrielidis Lindsay A. , Thornber Carol S. , Oczkowski Autumn
Published: May 2023

Sustainable aquaculture includes the aquaculture of non-fed crops that provide ecosystem services including nutrient extraction and water quality improvement. While shellfish are the most farmed sustainable aquaculture crops in the USA, shellfish farmers in the northeastern US have an interest in diversifying their crops and incorporating seaweeds into their farms. In this study, we worked with oyster farmers to investigate the potential for farming sugar kelp, Saccharina latissima, across different environmental regimes in coastal Rhode Island USA. Kelp seed spools were outplanted at two time points in the fall/winter of 2017 and 2018 at four sites and cultivated until harvest the following spring. Kelp performance (length, width, yield), tissue content, and nutrient extraction were determined for each line in each year; oyster growth was also measured monthly for one year at each site. We found that kelp could successfully grow in both shallow coastal lagoons and estuarine sites, although the timing of planting and placement of sites was important. Lines that were planted earlier (as soon as water temperatures<15°C) grew longer and yielded more biomass at harvest; overall, kelp blade yield ranged from 0.36 ± 0.01 to 11.26 ± 2.18 kg/m long line. We report little variation in the tissue quality (C:N) of kelp among sites, but differences in biomass production led to differences in nutrient extraction, which ranged from 0.28 ± 0.04 to 16.35 ± 4.26 g nitrogen/m long line and 8.93 ± 0.35 to 286.30 ± 74.66 g carbon/m long line. We found extensive variability in kelp growth within and between lines and between years, suggesting that crop consistency is a challenge for kelp farmers in the region. Our results suggest that, as there is a lower barrier in terms of permitting (versus starting a new aquaculture farm), it may be a worthwhile investment to add sugar kelp to existing oyster farms, provided they have suitable conditions. At current market rates of US$0.88-$3.30 per kg, farmers in southern New England have the potential to earn US$2,229 per 60 m longline. While seaweed aquaculture is growing, considerable barriers still exist that prevent wide-scale kelp aquaculture adoption by existing aquafarmers.
Successful simultaneous stenting of a pulmonary artery and vein in pulmonary vascular stenosis due to silicosis. Case report and literature review
Authors: Westhoff M. , Hardebusch T. , Litterst P. , Breithecker A. , Haas M. , Kuniss M. , Neumann T. , Guth S. , Wiedenroth C. B.
Published: May 2023

A 58-year-old patient was admitted to the emergency department due to severe respiratory insufficiency. Anamnesis revealed that the patient had experienced increasing stress dyspnea for a few months. Upon imaging, an acute pulmonary embolism was excluded, but peribronchial and hilar soft tissue proliferation with compression of central parts of the pulmonary circulation was found. The patient had a history of silicosis. The histology report showed tumor-free lymph node particles with prominent anthracotic pigment and dust depositions without evidence of IgG4-associated disease. The patient was administered steroid therapy and underwent simultaneous stenting of the left interlobular pulmonary artery and the upper right pulmonary vein. As a result, a significant improvement in symptoms and physical performance was achieved. The diagnosis of inflammatory or, in particular, fibrosing mediastinal processes can be challenging and important clinical symptoms must be taken into account, especially if the pulmonary vasculature is involved. In such cases, the possibility of interventional procedures should be examined in addition to drug therapy options.
Study on safety assessment methods of gravity anchors based on a simplified mechanical model
Authors: Li Hongru , Yang Min , Yin Xiaotao
Published: May 2023

Gravity anchor blocks are a common type of ground anchor used for suspension bridges, whose bearing depends on its large body and gravity. As there is no stratum requirement, the safety of the anchor block is important for bridge stability. This study summarizes all available estimation indexes, calculating methods, and evaluation criteria for gravity anchor block safety for the Ruili bank of the Banjin Dam grand suspension bridge. The anti-overturning, anti-sliding, base stress, and deformation safeties were comprehensively evaluated using methods including the suggested specification method (SM), simplified mechanical method (SMM), and finite element method (FEM), the results of which were compared and analyzed. The reasons for errors and improved formulas and working conditions were presented. The main conclusions were as follows. 1) The methods for calculating different evaluation indexes according to specifications lack consistency. Moreover, FEM requires that designers have good computer skills and has low feasibility in practice. 2) The SMM for gravity anchor block safety estimation as described in this study, whose indexes cover systematic and overall, the computational formula is simple and speedy, with relatively conservative results and good practicability. 3) SM, SMM, and FEM were all used for the safety estimation of gravity anchor blocks in Ruili bank. The anti-overturning and anti-sliding stability coefficients must all meet the specification requirements of 2.0. SM cannot be used to estimate the base tensile stress under limited conditions. SMM denoted tensile stress at 2.5 times the main cable design force, compared to 3.2 P for FEM. Deformation calculation methods are not given by SM, but can be suggested by SMM based on the elastic mechanics. The horizontal displacements under design load conditions were 122 mm (SMM), 108 mm (FEM), and 44 mm (composite foundation treated by root piles), with a safety standard of <80 mm. The vertical displacements were 338 mm (SMM), 110 mm (FEM), and 123 mm (composite foundation treated by root piles), with a safety standard of <160 mm. These findings proved the feasibility of SMM for the safety design of gravity anchor blocks in cases lacking regional experience.
Triple bottom line aspects and sustainable supply chain resilience: A structural equation modelling approach
Authors: Tundys Blanka , Wiśniewski Tomasz
Published: May 2023

The purpose of this paper is to investigate which of sustainability elements, in the context of triple bottom line (TBL), are used to build sustainable supply chain resilience. This paper presents a new body of knowledge and contribution to the literature by relating the triple bottom line (TBL) context to the building of sustainable supply chain resilience using structural equation modelling. The research were used to understand that individual sustainability factors matter and play a role in the context of supply chain resilience. A survey questionnaire was designed to collect this data from the research respondents. To statistical analysis was first Confirmatory Factor Analysis (CFA) conducted and used, then for the analysis and interpretation structural equation model. The findings indicate that individual sustainability factors matter and play a role in the context of supply chain resilience. A number of previous studies have developed broad catalogues of sustainability factors influencing supply chains, however, to date no convincing evidence has been presented as to which of the range of elements identified, and how they influence supply chain resilience building. Despite the large number of publications on sustainable supply chain and resilience building, there is still a gap and lack of proper consideration of TBL-related criteria as elements that can determine mechanisms for building supply chain resilience in the context of sustainable development. This paper operationalizes a using the structural research model to using a structural research model to investigate how and in which relationships the different elements of the triple bottom line influence the resilience of supply chains.
Attrition in the Gothenburg H70 birth cohort studies, an 18-year follow-up of the 1930 cohort
Authors: Rydén Lina , Wetterberg Hanna , Ahlner Felicia , Falk Erhag Hanna , Gudmundsson Pia , Guo Xinxin , Joas Erik , Johansson Lena , Kern Silke , Mellqvist Fässberg Madeleine , Najar Jenna , Ribbe Mats , Rydberg Sterner Therese , Sacuiu Simona , Samuelsson Jessica , Sigström Robert , Skoog Johan , Waern Margda , Zettergren Anna , Skoog Ingmar
Published: May 2023

Background

Longitudinal studies are essential to understand the ageing process, and risk factors and consequences for disorders, but attrition may cause selection bias and impact generalizability. We describe the 1930 cohort of the Gothenburg H70 Birth Cohort Studies, followed from age 70 to 88, and compare baseline characteristics for those who continue participation with those who die, refuse, and drop out for any reason during follow-up.

Methods

A population-based sample born 1930 was examined with comprehensive assessments at age 70 (N = 524). The sample was followed up and extended to increase sample size at age 75 (N = 767). Subsequent follow-ups were conducted at ages 79, 85, and 88. Logistic regression was used to analyze baseline characteristics in relation to participation status at follow-up.

Results

Refusal to participate in subsequent examinations was related to lower educational level, higher blood pressure, and lower scores on cognitive tests. Both attrition due to death and total attrition were associated with male sex, lower educational level, smoking, ADL dependency, several diseases, poorer lung function, slower gait speed, lower scores on cognitive tests, depressive symptoms, and a larger number of medications. Attrition due to death was also associated with not having a partner.

Conclusions

It is important to consider different types of attrition when interpreting results from longitudinal studies, as representativeness and results may be differently affected by different types of attrition. Besides reducing barriers to participation, methods such as imputation and weighted analyses can be used to handle selection bias.
Genetic diversity and genome-scale population structure of wild Indian major carp, Labeo catla (Hamilton, 1822), revealed by genotyping-by-sequencing
Authors: Sahoo Bismay , Das Gargee , Nandanpawar Priyanka , Priyadarshini Nirjharini , Sahoo Lakshman , Meher Prem Kumar , Udit Uday Kumar , Sundaray Jitendra Kumar , Das Paramananda
Published: May 2023

Labeo catla (catla) is the second most commercially important and widely cultured Indian major carp (IMC). It is indigenous to the Indo-Gangetic riverine system of India and the rivers of Bangladesh, Nepal, Myanmar, and Pakistan. Despite the availability of substantial genomic resources in this important species, detailed information on the genome-scale population structure using SNP markers is yet to be reported. In the present study, the identification of genome-wide single nucleotide polymorphisms (SNPs) and population genomics of catla was undertaken by re-sequencing six catla populations of riverine origin from distinct geographical regions. DNA isolated from 100 samples was used to perform genotyping-by-sequencing (GBS). A published catla genome with 95% genome coverage was used as the reference for mapping reads using BWA software. From a total of 472 million paired-end (150 × 2 bp) raw reads generated in this study, we identified 10,485 high-quality polymorphic SNPs using the STACKS pipeline. Expected heterozygosity (He) across the populations ranged from 0.162 to 0.20, whereas observed heterozygosity (Ho) ranged between 0.053 and 0.06. The nucleotide diversity (π) was the lowest (0.168) in the Ganga population. The within-population variation was found to be higher (95.32%) than the among-population (4.68%) variation. However, genetic differentiation was observed to be low to moderate, with Fst values ranging from 0.020 to 0.084, and the highest between Brahmani and Krishna populations. Bayesian and multivariate techniques were used to further evaluate the population structure and supposed ancestry in the studied populations using the structure and discriminant analysis of principal components (DAPC), respectively. Both analyses revealed the existence of two separate genomic clusters. The maximum number of private alleles was observed in the Ganga population. The findings of this study will contribute to a deeper understanding of the population structure and genetic diversity of wild populations of catla for future research in fish population genomics.
Interferon and autoantigens: intersection in autoimmunity
Authors: Antiochos Brendan , Casciola-Rosen Livia
Published: May 2023

Interferon (IFN) is a key component of the innate immune response. For reasons that remain incompletely understood, the IFN system is upregulated in several rheumatic diseases, particularly those that feature autoantibody production, such as SLE, Sjögren’s syndrome, myositis and systemic sclerosis. Interestingly, many of the autoantigens targeted in these diseases are components of the IFN system, representing IFN-stimulated genes (ISGs), pattern recognition receptors (PRRs), and modulators of the IFN response. In this review, we describe features of these IFN-linked proteins that may underlie their status as autoantigens. Note is also made of anti-IFN autoantibodies that have been described in immunodeficiency states.
Real-life impact of highly effective CFTR modulator therapy in children with cystic fibrosis
Authors: Olivier Margarete , Kavvalou Alexandra , Welsner Matthias , Hirtz Raphael , Straßburg Svenja , Sutharsan Sivagurunathan , Stehling Florian , Steindor Mathis
Published: May 2023

Introduction: Recently, cystic fibrosis transmembrane regulator modulator therapy with elexacaftor/tezacaftor/ivacaftor has become available for children with cystic fibrosis (CF) carrying at least one F508del mutation.

Objective: To assess the intermediate term effects of elexacaftor/tezacaftor/ivacaftor in children with cystic fibrosis in a real-world setting.

Methods: We performed a retrospective analysis of records of children with cystic fibrosis, who started elexacaftor/tezacaftor/ivacaftor between 8/2020 and 10/2022. Pulmonary function tests, nutritional status, sweat chloride and laboratory data were assessed before, 3 and 6 months after the start of elexacaftor/tezacaftor/ivacaftor respectively.

Results: Elexacaftor/tezacaftor/ivacaftor was started in 22 children 6–11 years and in 24 children 12–17 years. Twenty-seven (59%) patients were homozygous for F508del (F/F) and 23 (50%) patients were transitioned from ivacaftor/lumacaftor (IVA/LUM) or tezacaftor/ivacaftor (TEZ/IVA) to elexacaftor/tezacaftor/ivacaftor. Overall, mean sweat chloride concentration decreased by 59.3 mmol/L (95% confidence interval: −65.0 to −53.7 mmol/L, p < 0.0001) under elexacaftor/tezacaftor/ivacaftor. Sweat chloride concentration also decreased significantly after transition from IVA/LUM or TEZ/IVA to elexacaftor/tezacaftor/ivacaftor (−47.8 mmol/l; 95% confidence interval: −57.6 to −37.8 mmol/l, n = 14, p < 0.0001). Sweat chloride reduction was more marked in children with the F/F than in those with the F/MF genotype (69.4 vs 45.9 mmol/L, p < 0.0001). At 3 months follow-up, body-mass-index-z-score increased by 0.31 (95% CI, 0.2–0.42, p < 0.0001) with no further increase at 6 months. BMI-for-age-z-score was more markedly improved in the older group. Overall pulmonary function (percent predicted FEV1) at 3 months follow-up increased by 11.4% (95% CI: 8.0–14.9, p < 0.0001) with no further significant change after 6 months. No significant differences were noted between the age groups. Children with the F/MF genotype had a greater benefit regarding nutritional status and pulmonary function tests than those with the F/F genotype. Adverse events led to elexacaftor/tezacaftor/ivacaftor dose reduction in three cases and a temporary interruption of therapy in four cases.

Conclusion: In a real-world setting, elexacaftor/tezacaftor/ivacaftor therapy had beneficial clinical effects and a good safety profile in eligible children with cystic fibrosis comparable to previously published data from controlled clinical trials. The positive impact on pulmonary function tests and nutritional status seen after 3 months of elexacaftor/tezacaftor/ivacaftor therapy was sustained at 6 months follow-up.
Effects of phenylcapsaicin on aerobic capacity and physiological parameters in active young males: a randomized, triple-blinded, placebo-controlled, crossover trial
Authors: Jiménez-Martínez Pablo , Alix-Fages Carlos , Janicijevic Danica , Miras-Moreno Sergio , Chacón-Ventura Sara , Martín-Olmedo Juan J. , De La Cruz-Márquez Juan Carlos , Osuna-Prieto Francisco J. , Jurado-Fasoli Lucas , Amaro-Gahete Francisco J. , García-Ramos Amador , Colado Juan C.
Published: May 2023

Objective: Phenylcapsaicin (PC) is a new capsaicin analog which has exhibited a higher bioavailability. This sudy assessed the effects of a low dose (LD) of 0.625 mg and a high dose (HD) of 2.5 mg of PC on aerobic capacity, substrate oxidation, energy metabolism and exercise physiological variables in young males.

Materials and methods: Seventeen active males (age = 24.7 ± 6.0 years) enrolled to this randomized, triple-blinded, placebo-controlled, crossover trial. Participants attended the laboratory on 4 sessions separated by 72–96 h. A submaximal exercise test [to determine maximal fat oxidation (MFO) and the intensity at MFO (FATmax)] followed by a maximal incremental test (to determine VO2max) were performed in a preliminary session. The subsequent sessions only differed in the supplement ingested [LD, HD or placebo (PLA)] and consisted of a steady-state test (60 min at FATmax) followed by a maximal incremental test. Energy metabolism, substrate oxidation, heart rate, general (gRPE) and quadriceps (RPEquad) rate of perceived exertion, skin temperature and thermal perception were tested.

Results: Clavicle thermal perception was lower in HD compared to PLA and LD (p = 0.04) across time. HD reduced maximum heart rate in comparison to PLA and LD (p = 0.03). LD reported higher general RPE (RPEg) values during the steady-state test compared to PLA and HD across time (p = 0.02). HD and LD elicited higher peak of fat oxidation during the steady-state test compared with PLA (p = 0.05). Intra-test analyses revealed significant differences for fat oxidation (FATox) in favor of HD and LD compared to PLA (p = 0.002 and 0.002, respectively), and for carbohydrate oxidation (CHOox) (p = 0.05) and respiratory exchange ratio (RER) (p = 0.03) for PLA. In the incremental test, only general RPE at 60% of the maximal intensity (W) differed favoring HD (p ≤ 0.05).

Conclusion: Therefore, PC may contribute to increase aerobic capacity through the improvement of fat oxidation, maximum heart rate and perceptual responses during exercise.
Mental health state and its determinants in German university students across the COVID-19 pandemic: findings from three repeated cross-sectional surveys between 2019 and 2021
Authors: Tsiouris Angeliki , Werner Antonia M. , Tibubos Ana N. , Mülder Lina M. , Reichel Jennifer L. , Heller Sebastian , Schäfer Markus , Schwab Lisa , Rigotti Thomas , Stark Birgit , Dietz Pavel , Beutel Manfred E.
Published: May 2023

Background

Students were at an increased risk for elevated mental symptoms during the first year of the COVID-19 pandemic compared to pre-pandemic levels. As universities remained closed much longer than anticipated, the mental burden was expected to persist through the second year of the pandemic. The current study aimed to investigate the prevalence of mental distress from 2019 through 2021 and identify risk factors for elevated mental burden, focusing on gender.

Methods

We analyzed three cross-sectional online surveys among students at the University of Mainz, conducted in 2019 (n = 4,351), 2020 (n = 3,066), and 2021 (n = 1,438). Changes in the prevalence of depressive symptoms, anxiety, suicidal ideation, and loneliness were calculated using Pearson's chi-square tests and analyses of variance. Multiple linear regressions yielded associated risk factors.

Results

The proportion of students with clinically relevant depressive symptoms was significantly higher during the pandemic (38.9% in 2020, and 40.7% in 2021), compared to pre-pandemic (29.0% in 2019). Similarly, more students reported suicidal ideation and generalized anxiety during the pandemic with a peak in the second pandemic year (2021). The level of loneliness was significantly higher in 2020, compared to 2019, and remained at a high level in 2021 (p < 0.001, ηp2 = 0.142). Female and diverse/open gender, being single, living alone, and being a first-year student were identified as risk factors associated with mental burden during the pandemic.

Discussion

Mental burdens remained elevated among students through the second year of the pandemic and were associated with socio-demographic risk factors and pandemic-related concerns. Future research should monitor recovery and evaluate the need for psychosocial support.
Self-Assembled Monolayers Derived from Positively Charged Adsorbates on Plasmonic Substrates for MicroRNA Delivery: A Review
Authors: Hoang Johnson , Tajalli Pooria , Omidiyan Mina , Marquez Maria D. , Khantamat Orawan , Tuntiwechapikul Wirote , Li Chien-Hung , Kohlhatkar Arati , Tran Hung-Vu , Gunaratne Preethi H. , Lee T. Randall
Published: May 2023

MicroRNA (miRNA) has emerged as a promising alternative therapeutic treatment for cancer, but its delivery has been hindered by low cellular uptake and degradation during circulation. In this review, we discuss the various methods of delivering miRNA, including viral and non-viral delivery systems such as liposomes and nanoparticles. We also examine the use of nanoparticles for miRNA-based diagnostics. We focus specifically on non-viral delivery systems utilizing coinage metals in the form of nanoparticles and the use of self-assembled monolayers (SAMs) as a method of surface modification. We review the use of SAMs for the conjugation and delivery of small noncoding ribonucleic acid (ncRNA), particularly SAMs derived from positively charged adsorbates to generate charged surfaces that can interact electrostatically with negatively charged miRNA. We also discuss the effects of the cellular uptake of gold and other plasmonic nanoparticles, as well as the challenges associated with the degradation of oligonucleotides. Our review highlights the potential of SAM-based systems as versatile and robust tools for delivering miRNA and other RNAs in vitro and in vivo and the need for further research to address the challenges associated with miRNA delivery and diagnostics.
Holographic Optical Tweezers That Use an Improved Gerchberg–Saxton Algorithm
Authors: Zhou Zhehai , Hu Guoqing , Zhao Shuang , Li Huiyu , Zhang Fan
Published: May 2023

It is very important for holographic optical tweezers (OTs) to develop high-quality phase holograms through calculation by using some computer algorithms, and one of the most commonly used algorithms is the Gerchberg–Saxton (GS) algorithm. An improved GS algorithm is proposed in the paper to further enhance the capacities of holographic OTs, which can improve the calculation efficiencies compared with the traditional GS algorithm. The basic principle of the improved GS algorithm is first introduced, and then theoretical and experimental results are presented. A holographic OT is built by using a spatial light modulator (SLM), and the desired phase that is calculated by the improved GS algorithm is loaded onto the SLM to obtain expected optical traps. For the same sum of squares due to error SSE and fitting coefficient η, the iterative number from using the improved GS algorithm is smaller than that from using traditional GS algorithm, and the iteration speed is faster about 27%. Multi-particle trapping is first achieved, and dynamic multiple-particle rotation is further demonstrated, in which multiple changing hologram images are obtained continuously through the improved GS algorithm. The manipulation speed is faster than that from using the traditional GS algorithm. The iterative speed can be further improved if the computer capacities are further optimized.
Transforming a Computational Model from a Research Tool to a Software Product: A Case Study from Arc Welding Research
Authors: Murphy Anthony B. , Thomas David G. , Chen Fiona F. , Xiang Junting , Feng Yuqing
Published: May 2023

Arc welding is a thermal plasma process widely used to join metals. An arc welding model that couples fluid dynamic and electromagnetic equations was initially developed as a research tool. Subsequently, it was applied to improve and optimise industrial implementations of arc welding. The model includes the arc plasma, the electrode, and the workpiece in the computational domain. It incorporates several features to ensure numerical accuracy and reduce computation time and memory requirements. The arc welding code has been refactored into commercial-grade Windows software, ArcWeld, to address the needs of industrial customers. The methods used to develop ArcWeld and its extension to new arc welding regimes, which used the Workspace workflow platform, are presented. The transformation of the model to an integrated software application means that non-experts can now run the code after only elementary training. The user can easily visualise the results, improving the ability to analyse and generate insights into the arc welding process being modelled. These changes mean that scientific progress is accelerated, and that the software can be used in industry and assist welders’ training. The methods used are transferrable to many other research codes.
Risk Management of Supply Chain Green Finance Based on Sustainable Ecological Environment
Authors: Zhao Hailei
Published: May 2023

Green supply chain finance is a new financing method that focuses on corporate restructuring and promotes corporate capital flow and the development of environmental protection. This paper used BP neural network technology to study the green financing of the supply chain under the sustainable ecological environment. The method played an important role in the trial. Due to the more uncertain factors faced and the more complex environment, the risks of green supply chain finance are more hidden, diverse, and complex. The BP neural network is relatively mature in both network theory and performance. Its outstanding advantages are its strong nonlinear mapping ability and flexible network structure. The positive effect of BP neural network on green financial risk management is verified by experiments. Green supply chain finance is an innovative model of green finance. This experiment studies the risk management of green finance in supply chain and the evaluation index of green finance risk management through BP neural network method, and shows that the evaluation results are highly scientific. In addition, based on the green supply chain model, the historical data of different regions provide a scientific basis for the sustainable ecological development of the region. This paper provides guidance for the sustainable development of green finance in the supply chain and makes contributions to promoting the development of green economy. In order to control the risks of supply chain financing business, the risks of supply chain financing business are classified and analyzed, and specific project risk levels and points are determined to propose control measures to ensure effective control of the business risks.
Incidental Finding of Dirofilaria immitis (Spirurida: Onchocercidae) Microfilariae in the Bone Marrow of a Dog with Mixed Leishmania infantum-Dirofilaria immitis Infection
Authors: Lensi Ilaria , Lubas George , Papini Roberto Amerigo
Published: May 2023

We report a rare and interesting case of mixed infection with Leishmania infantum and Dirofilaria immitis associated with the incidental finding of microfilariae in the bone marrow of a 9-year-old, intact, male Bullmastiff which was seropositive to L. infantum. Clinical signs showed progressive weakness, pale mucosae membranes, and a very low body condition score. Laboratory abnormalities included moderate, normocytic, normochromic, non-regenerative anemia; mild leukocytosis, neutrophilia, monocytosis, and eosinopenia; low platelet count; elevated C reactive protein; mild hyperkalemia, hypoalbuminemia, and hyperbeta-2-globulinemia; and a low A/G ratio. Hypoadrenocorticism, euthyroid sick syndrome, and alteration in the fibrinolytic phase of hemostasis were also detected. Microfilariae were incidentally found in bone marrow cytology aspirate in the absence of clinical features indicative of co-infection with D. immitis. PCR confirmed the identification of the Dirofilaria species. It is assumed that the microfilariae may have left the microcirculation and migrated to bone marrow tissues by crossing the vessel wall. To the best of our knowledge, only one such case has been previously reported in dogs.