bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Lasting Insecticide Net Ownership, Access and Use in Southwest Ethiopia: A Community-Based Cross-Sectional Study
Authors: Seyoum Dinberu , Speybroeck Niko , Duchateau Luc , Brandt Patrick , Rosas-Aguirre Angel
Published: October 2017

Introduction:A large proportion of the Ethiopian population (approximately 68%) lives in malaria risk areas. Millions of long-lasting insecticide treated nets (LLINs) have been distributed as part of the malaria prevention and control strategy in the country. This study assessed the ownership, access and use of LLNs in the malaria endemic southwest Ethiopia. Methods: A community-based cross-sectional study was conducted in southwest Ethiopia during October–November 2015, including 836 households from sixteen villages around Gilgel-Gibe dam area. Indicators of ownership, access and use of LLINs were derived following the Roll Back Malaria (RBM) guidelines. Factors associated with failure for both LLIN access and use were analysed at household level using a multivariate logistic regression model. Results: The proportion of households with at least one LLIN was 82.7% (95% CI: 80.0, 85.1). However, only 68.9% (95% CI: 65.6, 71.9) had enough LLINs to cover all family members (with ≥one LLIN for every two persons). While 75.3% (95% CI: 68.4, 83.0) of the population was estimated to have accessed to LLINs, only 63.8% (95% CI: 62.3, 65.2) reported to have used a LLIN the previous night. The intra-household gap (i.e., households owning at least one LLIN, but unable to cover all family members) and the behavioral gap (i.e., household members who did not sleep under a LLIN despite having access to one) were 16.8% and 10.5%, respectively. Age, marital status and education of household heads, as well as household size and cooking using firewood were associated with the access to enough LLINs within households. Decreased access to LLINs at households was the main determinant for not achieving ≥80% household members sleeping under a LLIN the previous night. Other associated factors were household size and education level of household head. Conclusions: LLIN coverage levels in study villages remain below national targets of 100% for ownership and 80% for use. The access to enough LLINs within the households is the main restriction of LLIN use in the study area.
Effects of Late Gestational Fetal Exposure to Dexamethasone Administration on the Postnatal Hypothalamus-Pituitary-Adrenal Axis Response to Hypoglycemia in Pigs
Authors: Schiffner René , Rodríguez-González Guadalupe , Rakers Florian , Nistor Marius , Nathanielsz Peter , Daneva Teodora , Schwab Matthias , Lehmann Thomas , Schmidt Martin
Published: October 2017

Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pituitary-adrenocortical axis (HPAA), and correspondingly the adenocorticotropic hormone (ACTH) and cortisol levels after birth. The dosages required for these effects are critically discussed. Activation of the HPAA is related to metabolic syndrome and diabetes mellitus. Hypoglycemia is the classic side effect of antidiabetic treatment. We hypothesized that a low dosage of dexamethasone in late pregnancy alters the HPAA response to hypoglycemia in pigs. Methods: 12 pregnant sows were randomly assigned to two groups which received either a low-dose intramuscular injection (99th and 100th day of gestation) of dexamethasone (0.06 μg/kg body weight) or vehicle. Three months after birth, 18 dexamethasone-treated anaesthetized offspring and 12 control offspring underwent a 75 min hypoglycemic clamp (blood glucose below 4 mmol/L) procedure. Heart rate (HR), blood pressure, ACTH and cortisol levels and body weight (at birth and after three months) were recorded. Results: Dexamethasone-treated animals exhibited significantly elevated ACTH (139.9 ± 12.7 pg/mL) and cortisol (483.1 ± 30.3 nmol/L) levels during hypoglycemia as compared to the control group (41.7 ± 6.5 pg/mL and 257.9 ± 26.7 nmol/L, respectively), as well as an elevated HR (205.5 ± 5.7 bpm) and blood pressure (systolic: 128.6 ± 1.5, diastolic: 85.7 ± 0.7 mmHg) response as compared to the control group (153.2 ± 4.5 bpm; systolic: 118.6 ± 1.6, diastolic: 79.5 ± 1.4 mmHg, respectively; p < 0.001). Conclusions: Low-dose prenatal administration of dexamethasone not only exerts effects on the HPAA (ACTH and cortisol concentration) and vital parameters (HR and diastolic blood pressure) under baseline conditions, but also on ACTH, HR and systolic blood pressure during hypoglycemia.
Antifungal Effect of Polygodial on Botrytis cinerea, a Fungal Pathogen Affecting Table Grapes
Authors: Carrasco Héctor , Robles-Kelly Christian , Rubio Julia , Olea Andrés , Martínez Rolando , Silva-Moreno Evelyn
Published: October 2017

The antifungal activity of polygodial, a secondary metabolite extracted from Canelo, on mycelial growth of different Botrytis cinerea isolates has been evaluated. The results show that polygodial affects growth of normal and resistant isolates of B. cinerea with EC50 values ranging between 117 and 175 ppm. In addition, polygodial markedly decreases the germination of B. cinerea, i.e., after six hours of incubation the percentage of germination decreases from 92% (control) to 25% and 5% in the presence of 20 ppm and 80 ppm of polygodial, respectively. Morphological studies indicate that conidia treated with polygodial are smaller, with irregular membrane border, and a lot of cell debris, as compared to conidia in the control. The existence of polygodial-induced membrane damage was confirmed by SYTOX® Green uptake assay. Gene expression studies confirm that the effect of polygodial on B. cinerea is mainly attributed to inhibition of germination and appears at early stages of B. cinerea development. On the other hand, drimenol, a drimane with chemical structure quite similar to polygodial, inhibits the mycelial growth efficiently. Thus, both compounds inhibit mycelial growth by different mechanisms. The different antifungal activities of these compounds are discussed in terms of the electronic density on the double bond.
Reg Gene Expression in Periosteum after Fracture and Its In Vitro Induction Triggered by IL-6
Authors: Tohma Yasuaki , Dohi Yoshiko , Shobatake Ryogo , Uchiyama Tomoko , Takeda Maiko , Takasawa Shin , Tanaka Yasuhito , Ohgushi Hajime
Published: October 2017

The periosteum is a thin membrane that surrounds the outer surface of bones and participates in fracture healing. However, the molecular signals that trigger/initiate the periosteal reaction are not well established. We fractured the rat femoral bone at the diaphysis and fixed it with an intramedullary inserted wire, and the expression of regenerating gene (Reg) I, which encodes a tissue regeneration/growth factor, was analyzed. Neither bone/marrow nor muscle showed Reg I gene expression before or after the fracture. By contrast, the periosteum showed an elevated expression after the fracture, thereby confirming the localization of Reg I expression exclusively in the periosteum around the fractured areas. Expression of the Reg family increased after the fracture, followed by a decrease to basal levels by six weeks, when the fracture had almost healed. In vitro cultures of periosteal cells showed no Reg I expression, but the addition of IL-6 significantly induced Reg I gene expression. The addition of IL-6 also increased the cell number and reduced pro-apoptotic gene expression of Bim. The increased cell proliferation and reduction in Bim gene expression were abolished by transfection with Reg I siRNA, indicating that these IL-6-dependent effects require the Reg I gene expression. These results indicate the involvement of the IL-6/Reg pathway in the osteogenic response of the periosteum, which leads to fracture repair.
P2X4 Receptor-Dependent Ca2+ Influx in Model Human Monocytes and Macrophages
Authors: Layhadi Janice , Fountain Samuel
Published: October 2017

Monocytes and macrophages express a repertoire of cell surface P2 receptors for adenosine 5′-triphosphate (ATP) a damage-associated molecular pattern molecule (DAMP), which are capable of raising cytoplasmic calcium when activated. This is achieved either through direct permeation (ionotropic P2X receptors) or by mobilizing intracellular calcium stores (metabotropic P2Y receptors). Here, a side-by-side comparison to investigate the contribution of P2X4 receptor activation in ATP-evoked calcium responses in model human monocytes and macrophages was performed. The expression of P2X1, P2X4, P2X5 and P2X7 was confirmed by qRT-PCR and immunocytochemistry in both model monocyte and macrophage. ATP evoked a concentration-dependent increase in intracellular calcium in both THP-1 monocyte and macrophages. The sarco/endoplasmic reticulum Ca2+-ATPase inhibitor thasigargin (Tg) responses to the maximal ATP concentration (100 μM) in THP-1 monocytes, and responses in macrophage were significantly attenuated. Tg-resistant ATP-evoked calcium responses in the model macrophage were dependent on extracellular calcium, suggesting a requirement for calcium influx. Ivermectin (IVM) potentiated the magnitude of Tg-resistant component and slowed the decay of response in the model macrophage. The Tg-resistant component was attenuated by P2X4 antagonists 5-BDBD and PSB-12062 but not by the P2X1 antagonist Ro0437626 or the P2X7 antagonist A438079. shRNA-mediated P2X4 knockdown resulted in a significant reduction in Tg-resistant ATP-evoked calcium response as well as reduced sensitivities towards P2X4-specific pharmacological tools, IVM and PSB-12062. Inhibition of endocytosis with dynasore significantly reduced the magnitude of Tg-resistant component but substantially slowed decay response. Inhibition of calcium-dependent exocytosis with vacuolin-1 had no effect on the Tg-resistant component. These pharmacological data suggest that P2X4 receptor activation contributed significantly towards the ionotropic calcium response evoked by ATP of the model human macrophage.
New Trends for Reinforced Concrete Structures: Some Results of Exploratory Studies
Authors: Carmo Ricardo , Júlio Eduardo
Published: October 2017

Today, the concrete sector is being pushed to innovate in order to better address current challenges with higher competitiveness and more sustainable solutions. Different research studies have been conducted all over the world in which novel approaches and paths were proposed. It is important to spread information to define new strategies for the future of this industry. The enhancement of concrete properties and the impact of these changes in structural design are some of the topics analysed in those studies. This paper presents four experimental studies conducted by the authors where different types of concrete and structural members were tested. The common goal of these studies was to develop innovative solutions with high performance and low environmental impact. The scope of the first study was the structural behaviour of members produced with lightweight aggregate concrete (LWAC). Results of several beams, ties, and slabs are herein presented and analysed. The advantage of using glass fibre–reinforced polymer (GFRP) rebars was addressed in a second study, and main results obtained with this type of rebar are also herein presented. Recent advances in nanotechnology led to the development of concretes incorporating nanoparticles into the binder matrix. Typically, these nanoparticles have a diameter of 10–300 nanometers and are added to the mixture to reduce the porosity and increase the density of the binder matrix, improving the mechanical properties and durability. To analyse their influence on steel-to-concrete bonding and on the shear and flexural behaviour of the beams was the main goal of the third study herein described. Finally, a new concept to produce reinforced concrete members with high durability using a special concrete cover, which was the goal of the fourth study, is also herein presented.
Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson’s Disease
Authors: Al Shahrani Mesfer , Heales Simon , Hargreaves Iain , Orford Michael
Published: October 2017

Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular and ultimately tissue and organ dysfunction. Mitochondria, as well as being a source of ROS, are vulnerable to oxidative stress-induced damage with a number of key biomolecules being the target of oxidative damage by free radicals, including membrane phospholipids, respiratory chain complexes, proteins, and mitochondrial DNA (mt DNA). As a result, a deficit in cellular energy status may occur along with increased electron leakage and partial reduction of oxygen. This in turn may lead to a further increase in ROS production. Oxidative damage to certain mitochondrial biomolecules has been associated with, and implicated in the pathophysiology of a number of diseases. It is the purpose of this review to discuss the impact of such oxidative stress and subsequent damage by reviewing our current knowledge of the pathophysiology of several inherited mitochondrial disorders together with our understanding of perturbations observed in the more commonly acquired neurodegenerative disorders such as Parkinson’s disease (PD). Furthermore, the potential use and feasibility of antioxidant therapies as an adjunct to lower the accumulation of damaging oxidative species and hence slow disease progression will also be discussed.
Experimental Analysis of Grease Friction Properties on Sliding Textured Surfaces
Authors: Hua Xijun , Puoza Julius , Zhang Peiyun , Xie Xuan , Yin Bifeng
Published: October 2017

There is comprehensive work on the tribological properties and lubrication mechanisms of oil lubricant used on textured surfaces, however the use of grease lubrication on textured surfaces is rather new. This research article presents an experimental study of the frictional behaviours of grease lubricated sliding contact under mixed lubrication conditions. The influences of surface texture parameters on the frictional properties were investigated using a disc-on-ring tribometer. The results showed that the friction coefficient is largely dependent on texture parameters, with higher and lower texture density resulting in a higher friction coefficient at a fixed texture depth. The sample with texture density of 15% and texture depth of 19 μm exhibited the best friction properties in all experimental conditions because it can store more grease and trap wear debris. The reduction of friction is mainly attributable to the formation of a stable grease lubrication film composed of oil film, transfer film and deposited film, and the hydrodynamic pressure effect of the surface texture, which increases the mating gap and reduces the probability of asperity contact. This result will help in understanding the tribological behaviour of grease on a textured surface and in predicting the lubrication conditions of sliding bearings for better operation in any machinery.
(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione—Synthesis and Crystallographic Studies
Authors: Mieczkowski Adam , Trzybiński Damian , Wilczek Marcin , Psurski Mateusz , Bagiński Maciej , Bieszczad Bartosz , Mroczkowska Magdalena , Woźniak Krzysztof
Published: October 2017

(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(11H,12aH)-dione was obtained in a three-step, one-pot synthesis, starting from optically pure (S)-2-piperazine carboxylic acid dihydrochloride. Selective acylation of the β-nitrogen atom followed by condensation with isatoic anhydride and cyclization with HATU/DIPEA to a seven-member benzodiazepine ring, led to the tricyclic benzodiazepine derivative. Crystallographic studies and initial biological screening were performed for the title compound.
Pore Size Distribution in Granular Material Microstructure
Authors: Roozbahani M. , Borela Rodrigo , Frost J.
Published: October 2017

Pore scale modeling plays a key role in fluid flow through porous media and associated macroscale constitutive relationships. The polyhedral shape and effective local pore size within granular material microstructure are computed in this study by means of the Euclidean Distance Transform (EDT), a local maxima search (non-maximum suppression), and a segmentation process. Various synthetic packed particles are simulated and employed as comparative models during the computation of pore size distribution (PSD). Reconstructed un-sheared and sheared Ottawa 20–30 sand samples are used to compute PSD for non-trivial and non-spherical models.
Analysis of the Microstructure and Mechanical Properties of Titanium-Based Composites Reinforced by Secondary Phases and B4C Particles Produced via Direct Hot Pressing
Authors: Montealegre-Melendez Isabel , Arévalo Cristina , Ariza Enrique , Pérez-Soriano Eva , Rubio-Escudero Cristina , Kitzmantel Michael , Neubauer Erich
Published: October 2017

In the last decade, titanium metal matrix composites (TMCs) have received considerable attention thanks to their interesting properties as a consequence of the clear interface between the matrix and the reinforcing phases formed. In this work, TMCs with 30 vol % of B4C are consolidated by hot pressing. This technique is a powder metallurgy rapid process. Incorporation of the intermetallic to the matrix, 20 vol % (Ti-Al), is also evaluated. Here, the reinforcing phases formed by the reaction between the titanium matrix and the ceramic particles, as well as the intermetallic addition, promote substantial variations to the microstructure and to the properties of the fabricated composites. The influences of the starting materials and the consolidation temperature (900 °C and 1000 °C) are investigated. By X-ray diffraction, scanning and transmission electron microscopy analysis, the in-situ-formed phases in the matrix and the residual ceramic particles were studied. Furthermore, mechanical properties are studied through tensile and bending tests in addition to other properties, such as Young’s modulus, hardness, and densification of the composites. The results show the significant effect of temperature on the microstructure and on the mechanical properties from the same starting powder. Moreover, the Ti-Al addition causes variation in the interface between the reinforcement and the matrix, thereby affecting the behaviour of the TMCs produced at the same temperature.
Ultra-Thin Multi-Band Polarization-Insensitive Microwave Metamaterial Absorber Based on Multiple-Order Responses Using a Single Resonator Structure
Authors: Cheng Yong , Cheng Zheng , Mao Xue , Gong Rong
Published: October 2017

We design an ultra-thin multi-band polarization-insensitive metamaterial absorber (MMA) using a single circular sector resonator (CSR) structure in the microwave region. Simulated results show that the proposed MMA has three distinctive absorption peaks at 3.35 GHz, 8.65 GHz, and 12.44 GHz, with absorbance of 98.8%, 99.7%, and 98.3%, respectively, which agree well with an experiment. Simulated surface current distributions of the unit-cell structure reveal that the triple-band absorption mainly originates from multiple-harmonic magnetic resonance. The proposed triple-band MMA can remain at a high absorption level for all polarization of both transverse-electric (TE) and transverse-magnetic (TM) modes under normal incidence. Moreover, by further optimizing the geometric parameters of the CSRs, four-band and five-band MMAs can also be obtained. Thus, our design will have potential application in detection, sensing, and stealth technology.
Krishnolides A–D: New 2-Ketokhayanolides from the Krishna Mangrove, Xylocarpus moluccensis
Authors: Zhang Qun , Satyanandamurty Tirumani , Shen Li , Wu Jun
Published: October 2017

Four new khayanolide-type limonoids with a 2-carbonyl group, named krishnolides A–D (1–4), were isolated from the seeds of an Indian mangrove, Xylocarpus moluccensis, collected in the mangrove swamp of Krishna estuary, Andhra Pradesh. The relative and absolute configurations of these compounds were established by HR-ESIMS, extensive NMR investigations, single-crystal X-ray diffraction analysis with CuKα radiation, and experimental electronic circular dichroism (ECD) spectra. Krishnolides A–D are unusual khayanolides containing two large ester substituents of five or four carbon atoms at the C-3 and C-30 positions, respectively. Krishnolide A, containing an 8,14-epoxy group, exhibited moderate anti-Human Immunodeficiency Virus (HIV) activity with an IC50 value of 17.45 ± 1.65 μM and a CC50 value of 78.45 ± 1.69 μM, respectively. This is not only the first report of natural khayanolides from Indian mangroves of the genus Xylocarpus, but also the first report of the anti-HIV activity of khayanolide.
Numerical Predictions of the Occurrence of Necking in Deep Drawing Processes
Authors: Chalal Hocine , Abed-Meraim Farid
Published: October 2017

In this work, three numerical necking criteria based on finite element (FE) simulations are proposed for the prediction of forming limit diagrams (FLDs) for sheet metals. An elastic–plastic constitutive model coupled with the Lemaitre continuum damage theory has been implemented into the ABAQUS/Explicit software to simulate simple sheet stretching tests as well as Erichsen deep drawing tests with various sheet specimen geometries. Three numerical criteria have been investigated in order to establish an appropriate necking criterion for the prediction of formability limits. The first numerical criterion is based on the analysis of the thickness strain evolution in the central part of the specimens. The second numerical criterion is based on the analysis of the second time derivative of the thickness strain. As to the third numerical criterion, it relies on a damage threshold associated with the occurrence of necking. The FLDs thus predicted by numerical simulation of simple sheet stretching with various specimen geometries and Erichsen deep drawing tests are compared with the experimental results.
Study of the Influence of TiB Content and Temperature in the Properties of In Situ Titanium Matrix Composites
Authors: Arévalo Cristina , Montealegre-Melendez Isabel , Pérez-Soriano Eva , Ariza Enrique , Kitzmantel Michael , Neubauer Erich
Published: October 2017

This work focuses on the study of the microstructure, hardening, and stiffening effect caused by the secondary phases formed in titanium matrices. These secondary phases originated from reactions between the matrix and boron particles added in the starting mixtures of the composites. Not only was the composite composition studied as an influencing factor in the behaviour of the composites, but also different operational temperatures. Three volume percentages of boron content were tested (0.9 vol %, 2.5 vol %, and 5 vol % of amorphous boron). The manufacturing process used to produce the composites was inductive hot pressing, which operational temperatures were between 1000 and 1300 °C. Specimens showed optimal densification. Moreover, microstructural studies revealed the formation of TiB in various shapes and proportions. Mechanical testing confirmed that the secondary phases had a positive influence on properties of the composites. In general, adding boron particles increased the hardness and stiffness of the composites; however rising temperatures resulted in greater increases in stiffness than in hardness.
Rethinking the Design of Low-Cost Point-of-Care Diagnostic Devices
Authors: Kimani Faith , Mwangi Samuel , Kwasa Benjamin , Kusow Abdi , Ngugi Benjamin , Chen Jiahao , Liu Xinyu , Cademartiri Rebecca , Thuo Martin
Published: October 2017

Reducing the global diseases burden requires effective diagnosis and treatment. In the developing world, accurate diagnosis can be the most expensive and time-consuming aspect of health care. Healthcare cost can, however, be reduced by use of affordable rapid diagnostic tests (RDTs). In the developed world, low-cost RDTs are being developed in many research laboratories; however, they are not being equally adopted in the developing countries. This disconnect points to a gap in the design philosophy, where parameterization of design variables ignores the most critical component of the system, the point-of-use stakeholders (e.g., doctors, nurses and patients). Herein, we demonstrated that a general focus on reducing cost (i.e., “low-cost”), rather than efficiency and reliability is misguided by the assumption that poverty reduces the value individuals place on their well-being. A case study of clinicians in Kenya showed that “zero-cost” is a low-weight parameter for point-of-use stakeholders, while reliability and standardization are crucial. We therefore argue that a user-driven, value-addition systems-engineering approach is needed for the design of RDTs to enhance adoption and translation into the field.
Stenotrophomonas maltophilia: A Gram-Negative Bacterium Useful for Transformations of Flavanone and Chalcone
Authors: Kostrzewa-Susłow Edyta , Dymarska Monika , Guzik Urszula , Wojcieszyńska Danuta , Janeczko Tomasz
Published: October 2017

A group of flavones, isoflavones, flavanones, and chalcones was subjected to small-scale biotransformation studies with the Gram-negative Stenotrophomonas maltophilia KB2 strain in order to evaluate the capability of this strain to transform flavonoid compounds and to investigate the relationship between compound structure and transformation type. The tested strain transformed flavanones and chalcones. The main type of transformation of compounds with a flavanone moiety was central heterocyclic C ring cleavage, leading to chalcone and dihydrochalcone structures, whereas chalcones underwent reduction to dihydrochalcones and cyclisation to a benzo-γ-pyrone moiety. Substrates with a C-2–C-3 double bond (flavones and isoflavones) were not transformed by Stenotrophomonas maltophilia KB2.
Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation
Authors: Pagano Bruno , Caterino Marco , Filosa Rosanna , Giancola Concetta
Published: October 2017

Harmine belongs to a group of β-carboline alkaloids endowed with antitumor properties. Harmine and its derivatives are thought to bind to DNA and interfere with topoisomerase activities. We investigated the base-dependent binding of harmine, and three of its synthetic anticancer-active derivatives to the genomic DNA from calf thymus and two synthetic 20-mer double helices, the poly(dG-dC)·poly(dG-dC) and the poly(dA-dT)·poly(dA-dT), by means of UV-Vis and circular dichroism (CD) spectroscopies. The data show that the DNA binding and stabilising properties of the investigated derivatives are base pair-dependent. These results could be used as a guide to design and develop further bioactive analogues.
UPLC-PDA-Q/TOF-MS Profile of Polyphenolic Compounds of Liqueurs from Rose Petals (Rosa rugosa)
Authors: Cendrowski Andrzej , Ścibisz Iwona , Kieliszek Marek , Kolniak-Ostek Joanna , Mitek Marta
Published: October 2017

Polyphenolic compounds, as a secondary metabolite of plants, possess great nutritional and pharmacological potential. Herein, we applied the green analytical method to study the nutrient profile of Rosa rugosa petals and liqueurs manufactured from them. Using the fast and validated ultra performance liquid chromatography-photodiode detector-quadrupole/time of flight-mass spectrometry (UPLC-PDA-Q/TOF-MS) method, we confirm the presence of the following compounds: phenolic acids, flavonols, flavan-3-ols and hydrolisable tannins (gallotannins and ellagitannins). R. rugosa petals contains up to 2175.43 mg polyphenols per 100 g fresh weight, therein 1517.01 mg ellagitannins per 100 g fresh weight. Liqueurs, traditionally manufactured from said petals using a conventional extraction method (maceration), also contain polyphenols in significant amounts (from 72% to 96% corresponding to percentage of theoretical polyphenol content in the used petals), therein ellagitannins amount to 69.7% on average. We confirmed that traditional maceration, most common for the isolation of polyphenols, is still suitable for the food industry due to its using aqueous ethanol, a common bio-solvent, easily available in high purity and completely biodegradable. Therefore R. rugosa used as a food may be considered as an ellagitannin-rich plant of economic importance. Manufactured rose liqueurs were stable and kept all their properties during the whole period of aging.
The Compounds Responsible for the Sensory Profile in Monovarietal Virgin Olive Oils
Authors: Campestre Cristina , Angelini Guido , Gasbarri Carla , Angerosa Franca
Published: October 2017

Monovarietal virgin olive oils (VOOs) are very effective to study relationships among sensory attributes, the compounds responsible for flavour, and factors affecting them. The stimulation of the human sensory receptors by volatile and non-volatile compounds present in monovarietal virgin olive oils gives rise to the sensory attributes that describe their peculiar delicate and fragrant flavours. The formation of these compounds is briefly illustrated and the influence of the agronomic and technological factors that affect their concentrations in the oil is examined. The relationships between compounds responsible for the olive oil flavour and sensory attributes are discussed. Several approaches for the varietal differentiation of monovarietal virgin olive oils are also overviewed.
‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents
Authors: Li Xiang , Wu Yue , Wang Yanyan , You Qidong , Zhang Xiaojin
Published: October 2017

DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor druglike properties. In order to improve the druglike properties and in vivo antitumor potency, a novel series of ten triazole-bearing caged xanthone derivatives of DDO-6101 has been efficiently synthesized by ‘click chemistry’ and evaluated for their in vitro antitumor activity and druglike properties. Most of the target compounds have sustained cytotoxicity against A549, HepG2, HCT116, and U2OS cancer cells and possess improved aqueous solubility, as well as permeability. Notably, these caged xanthones are also active towards taxol-resistant or cisplatin-resistant A549 cancer cells. Taking both the in vitro activities and druglike properties into consideration, compound 8g has been advanced into in vivo efficacy experiments. The results reveal that 8g (named as DDO-6318), both by intravenous or per os administration, are much more potent than the lead DDO-6101 in A549-transplanted mice models and it could be a promising antitumor candidate for further evaluation.
Semisynthesis, an Anti-Inflammatory Effect of Derivatives of 1β-Hydroxy Alantolactone from Inula britannica
Authors: Chen Lin , Zhang Jian-Ping , Liu Xin , Tang Jiang-Jiang , Xiang Ping , Ma Xing-Ming
Published: October 2017

1β-hydroxy alantolactone, a sesquiterpene lactone mainly isolated from Inula genus plants, exhibits potent anti-inflammatory and anticancer activities. In this work, 1β-hydroxy alantolactone was isolated and five derivatives were prepared through different reactions at the C1-OH and C13-methylene motifs. The structure–activity relationships (SAR) of anti-inflammatory effects against NO production in RAW264.7 cells showed that the α-methylene-γ-butyrolactone motif was essential for NO production suppression and that retaining the C1-OH group can remarkably improve this effect. The NF-κB signaling pathway plays a pivotal role in the regulation of NO expression. Moreover, the levels of p65 and p50 phosphorylation were investigated and active compound 1 inhibited phosphorylation of p65 and p50 in TNF-α-induced NF-κB signaling. Further molecular docking suggested that 1 may target the p65 of NF-κB.
Fluorescent “Turn-Off” Detection of Fluoride and Cyanide Ions Using Zwitterionic Spirocyclic Meisenheimer Compounds
Authors: Benet Marina , Villabona Marc , Llavina Carles , Mena Silvia , Hernando Jordi , Al-Kaysi Rabih O. , Guirado Gonzalo
Published: October 2017

Stable zwitterionic spirocyclic Meisenheimer compounds were synthesized using a one-step reaction between picric acid and diisopropyl (ZW1) or dicyclohexyl (ZW3) carbodiimide. A solution of these compounds displays intense orange fluorescence upon UV or visible light excitation, which can be quenched or “turned-off” by adding a mole equivalent amount of F− or CN− ions in acetonitrile. Fluorescence is not quenched in the presence of other ions such as Cl−, Br−, I−, NO2−, NO3−, or H2PO4−. These compounds can therefore be utilized as practical colorimetric and fluorescent probes for monitoring the presence of F− or CN− anions.
Controlling the Mechanical Properties of Bulk Metallic Glasses by Superficial Dealloyed Layer
Authors: Wang Chaoyang , Li Man , Zhu Mo , Wang Han , Qin Chunling , Zhao Weimin , Wang Zhifeng
Published: October 2017

Cu50Zr45Al5 bulk metallic glass (BMG) presents high fracture strength. For improving its plasticity and controlling its mechanical properties, superficial dealloying of the BMG was performed. A composite structure containing an inner rod-shaped Cu-Zr-Al amorphous core with high strength and an outer dealloyed nanoporous layer with high energy absorption capacity was obtained. The microstructures and mechanical properties of the composites were studied in detail. It was found, for the first time, that the mechanical properties of Cu50Zr45Al5 BMG can be controlled by adjusting the width of the buffer deformation zone in the dealloyed layer, which can be easily manipulated with different dealloying times. As a result, the compressive strength, compressive strain, and energy absorption capacity of the BMGs can be effectively modulated from 0.9 to 1.5 GPa, from 2.9% to 4.7%, and from 29.1 to 40.2 MJ/m3, respectively. The paper may open a door for developing important engineering materials with regulable and comprehensive performances.
Food-Related Impulsivity in Obesity and Binge Eating Disorder—A Systematic Update of the Evidence
Authors: Giel Katrin , Teufel Martin , Junne Florian , Zipfel Stephan , Schag Kathrin
Published: October 2017

The specific eating pattern of Binge Eating Disorder (BED) patients has provoked the assumption that BED might represent a phenotype within the obesity spectrum that is characterized by increased impulsivity. Following the guidelines of the PRISMA statement (preferred reporting items for systematic reviews and meta-analyses), we here provide a systematic update on the evidence on food-related impulsivity in obese individuals, with and without BED, as well as normal-weight individuals. We separately analyzed potential group differences in the impulsivity components of reward sensitivity and rash-spontaneous behavior. Our search resulted in twenty experimental studies with high methodological quality. The synthesis of the latest evidence consolidates conclusions drawn in our initial systematic review that BED represents a distinct phenotype within the obesity spectrum that is characterized by increased impulsivity. Rash-spontaneous behavior in general, and specifically towards food, is increased in BED, while food-specific reward sensitivity is also increased in obese individuals without BED, but potentially to a lesser degree. A major next step for research entails the investigation of sub-domains and temporal components of inhibitory control in BED and obesity. Based on the evidence of impaired inhibitory control in BED, affected patients might profit from interventions that address impulsive behavior.
Social Demography of Transitional Dietary Patterns in Thailand: Prospective Evidence from the Thai Cohort Study
Authors: Papier Keren , Jordan Susan , D’Este Catherine , Banwell Cathy , Yiengprugsawan Vasoontara , Seubsman Sam-ang , Sleigh Adrian
Published: October 2017

In recent decades, a health-risk transition with changes in diet and lifestyle in low and middle-income countries (LMICs) led to an emergence of chronic diseases. These trends in Southeast Asian LMICs are not well studied. Here, we report on transitional dietary patterns and their socio-demographic predictors in Thai adults. Dietary data in 2015 were from a random sub-sample (N = 1075) of 42,785 Thai Cohort Study (TCS) members who completed all three TCS surveys (2005, 2009, 2013). Principle Component Analysis identified dietary patterns and multivariable linear regression assessed associations (Beta estimates (ß) and confidence intervals (CIs)) between socio-demographic factors and dietary intake pattern scores. Four dietary patterns emerged: Healthy Transitional, Fatty Western, Highly Processed, and Traditional. In women, higher income (≥30,001 Baht/month vs. ≤10,000) and managerial work (vs. office assistant) was associated with lower scores for Traditional (ß = −0.67, 95% CI −1.15, −0.19) and Fatty Western diets (ß = −0.60, 95% CI −1.14, −0.05), respectively. University education associated with lower Highly Processed (ß = −0.57, 95% CI −0.98, −0.17) and higher Traditional diet scores (ß = 0.42, 95% CI 0.03, 0.81). In men and women, urban residence associated with higher Fatty Western and lower Traditional diets. Local policy makers should promote healthy diets, particularly in urban residents, in men, and in low-SEP adults.
Effect of Probiotics and Prebiotics on Immune Response to Influenza Vaccination in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Lei Wei-Te , Shih Pei-Ching , Liu Shu-Jung , Lin Chien-Yu , Yeh Tzu-Lin
Published: October 2017

We conducted a meta-analysis to evaluate the effects of probiotics and prebiotics on the immune response to influenza vaccination in adults. We conducted a literature search of Pubmed, Embase, the Cochrane Library, the Cumulative Index to Nursing and Allied Health (CINAHL), Airiti Library, and PerioPath Index to Taiwan Periodical Literature in Taiwan. Databases were searched from inception to July 2017. We used the Cochrane Review risk of bias assessment tool to assess randomized controlled trial (RCT) quality. A total of 20 RCTs comprising 1979 adults were included in our systematic review. Nine RCTs including 623 participants had sufficient data to be pooled in a meta-analysis. Participants who took probiotics or prebiotics showed significant improvements in the H1N1 strain seroprotection rate (with an odds ratio (OR) of 1.83 and a 95% confidence interval (CI) of 1.19–2.82, p = 0.006, I2 = 0%), the H3N2 strain seroprotection rate (OR = 2.85, 95% CI = 1.59–5.10, p < 0.001, I2 = 0%), and the B strain seroconversion rate (OR = 2.11, 95% CI = 1.38–3.21, p < 0.001, I2 = 0%). This meta-analysis suggested that probiotics and prebiotics are effective in elevating immunogenicity by influencing seroconversion and seroprotection rates in adults inoculated with influenza vaccines.
Properties of Electrospun Nanofibers of Multi-Block Copolymers of [Poly-ε-caprolactone-b-poly(tetrahydrofuran-co-ε-caprolactone)]m Synthesized by Janus Polymerization
Authors: Shah Muhammad , Yang Zhening , Li Yao , Jiang Liming , Ling Jun
Published: October 2017

Novel biodegradable multiblock copolymers of [PCL-b-P(THF-co-CL)]m with PCL fractions of 53.3 and 88.4 wt % were prepared by Janus polymerization of ε-caprolactone (CL) and tetrahydrofuran (THF). Their electrospun mats were obtained with optimized parameters containing bead-free nanofibers whose diameters were between 290 and 520 nm. The mechanical properties of the nanofiber scaffolds were measured showing the tensile strength and strain at break of 8–10 MPa and 123–161%, respectively. Annealing improved their mechanical properties and their tensile strength and strain at break of the samples increased to 10–13 MPa and 267–338%, respectively. Due to the porous structure and crystallization in nanoscale confinement, the mechanical properties of the nanofiber scaffolds appeared as plastics, rather than as the elastomers observed in bulk thermal-molded film.
Reincarnation: Mechanics, Narratives, and Implications
Authors: Chapple Christopher
Published: October 2017

This essay explores the mechanics associated with rebirth, noting differences between Hindu, Buddhist, and Jain narratives. It examines the concept of subtle body and the liṅgam in Sāṃkhya. According to the Hindu tradition, the remains of the departed person, when cremated, merge with clouds in the upper atmosphere. As the monsoon rain clouds gather, the leftovers mingle with the clouds, returning to earth and eventually finding new life in complex biological cycles. According to Tibetan and Chinese Buddhism, the remains of a person take a ghostly form for 49 days until taking a new birth. According to Jainism, the departed soul immediately travels to the new birth realm at the moment of death. According to Jain karma theory, in the last third of one’s life, a living being makes a fateful choice that determines his or her next embodiment. The 20th century Hindu Yoga teacher Paramahamsa Yogananda, in his commentary on the Bhagavad Gita, provides an alternate description of a twofold astral and causal body. One hallmark of the Buddha and of the 24 Jain Tīrthaṅkaras was that they remembered all the lives they had lived and the lessons learned in those lives. The Buddha recalled 550 past lives and used these memories to fuel many of his lectures. Mahāvīra remembered his past lives and also the past lives of others. Patañjali’s Yoga Sūtra states that through the perfection of giving up all things, including psychological attachments, one spontaneously will remember past lives. In the Yogavāsiṣṭha, a Hindu text, Puṇya remembers the past lives of his grieving brother as well as his own prior experiences.
The Aerosol Index and Land Cover Class Based Atmospheric Correction Aerosol Optical Depth Time Series 1982–2014 for the SMAC Algorithm
Authors: Jääskeläinen Emmihenna , Manninen Terhikki , Tamminen Johanna , Laine Marko
Published: October 2017

Atmospheric effects, especially aerosols, are a significant source of uncertainty for optical remote sensing of surface parameters, such as albedo. Also to achieve a homogeneous surface albedo time series, the atmospheric correction has to be homogeneous. However, a global homogeneous aerosol optical depth (AOD) time series covering several decades did not previously exist. Therefore, we have constructed an AOD time series 1982–2014 using aerosol index (AI) data from the satellite measurements of the Total Ozone Mapping Spectrometer (TOMS) and the Ozone Monitoring Instrument (OMI), together with the Solar zenith angle and land use classification data. It is used as input for the Simplified Method for Atmospheric Correction (SMAC) algorithm when processing the surface albedo time series CLARA-A2 SAL (the Surface ALbedo from the Satellite Application Facility on Climate Monitoring project cLoud, Albedo and RAdiation data record, the second release). The surface reflectance simulations using the SMAC algorithm for different sets of satellite-based AOD data show that the aerosol-effect correction using the constructed TOMS/OMI based AOD data is comparable to using other satellite-based AOD data available for a shorter time range. Moreover, using the constructed TOMS/OMI based AOD as input for the atmospheric correction typically produces surface reflectance [-20]values closer to those obtained using in situ AOD values than when using other satellite-based AOD data.
Species Richness (of Insects) Drives the Use of Acoustic Space in the Tropics
Authors: Aide T. , Hernández-Serna Andres , Campos-Cerqueira Marconi , Acevedo-Charry Orlando , Deichmann Jessica
Published: October 2017

Acoustic ecology, or ecoacoustics, is a growing field that uses sound as a tool to evaluate animal communities. In this manuscript, we evaluate recordings from eight tropical forest sites that vary in species richness, from a relatively low diversity Caribbean forest to a megadiverse Amazonian forest, with the goal of understanding the relationship between acoustic space use (ASU) and species diversity across different taxonomic groups. For each site, we determined the acoustic morphospecies richness and composition of the biophony, and we used a global biodiversity dataset to estimate the regional richness of birds. Here, we demonstrate how detailed information on activity patterns of the acoustic community (<22 kHz) can easily be visualized and ASU determined by aggregating recordings collected over relatively short periods (4–13 days). We show a strong positive relationship between ASU and regional and acoustic morphospecies richness. Premontane forest sites had the highest ASU and the highest species richness, while dry forest and montane sites had lower ASU and lower species richness. Furthermore, we show that insect richness was the best predictor of variation in total ASU, and that insect richness was proportionally greater at high-diversity sites. In addition, insects used a broad range of frequencies, including high frequencies (>8000 Hz), which contributed to greater ASU. This novel approach for analyzing the presence and acoustic activity of multiple taxonomic groups contributes to our understanding of ecological community dynamics and provides a useful tool for monitoring species in the context of restoration ecology, climate change and conservation biology.
Enhanced Resolution of Microwave Sounder Imagery through Fusion with Infrared Sensor Data
Authors: Yanovsky Igor , Behrangi Ali , Wen Yixin , Schreier Mathias , Dang Van , Lambrigtsen Bjorn
Published: October 2017

The images acquired by microwave sensors are blurry and have low resolution. On the other hand, the images obtained using infrared/visible sensors are often of higher resolution. In this paper, we develop a data fusion methodology and apply it to enhance the resolution of a microwave image using the data from a collocated infrared/visible sensor. Such an approach takes advantage of the spatial resolution of the infrared instrument and the sensing accuracy of the microwave instrument. The model leverages sparsity in signals and is based on current research in sparse optimization and compressed sensing. We tested our method using a precipitation scene captured with the Advanced Microwave Sounding Unit (AMSU-B) microwave instrument and the Advanced Very High Resolution Radiometer (AVHRR) infrared instrument and compared the results to simultaneous radar observations. We show that the data fusion product is better than the original AMSU-B and AVHRR observations across all statistical indicators.