bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Corporate Political Activity an Investment or Agency? An Application of System GMM Approach
Authors: Lin Woon Leong
Published: January 2019

Corporate political activity (CPA) has been recognized as bearing a significant impact on financial performance (FP). Nevertheless, there has been a lack of considerable research to date. The results of the research regarding the relationship between CPA and FP have been contradictory and this has necessitated further investigation of this relationship. Nonetheless, rather than examining the relationship between CPA and FP, research scholars have revealed that a contingency perspective must be employed for revealing the conditions and the context which enhance the relationship between these two constructs. This study offers a quite distinctive viewpoint with respect to the link between CPA and FP as regards the corporate reputation perspective. For this reason, the study obtained data from the Fortune list of top 100 World Most Admired Companies (WMAC) for the period of 2007 and 2016. This data was utilized to examine the relationship between CPA and FP using the dynamic panel data system GMM (Generalized Method of Moments) estimator. This study finds virtually no support for the hypothesis that lobbying and PACs (political action committees) represent an investment in political capital. Instead, CPA is symptomatic of agency problems within firms. This study also argues that corporate reputation moderates the effect of CPA on the FP and the analysis supports the argument. Our results are particularly useful in light of the reputable corporation, which is greatly to likely increase the use of corporate funds for political contributions.
Brillouin Optical Correlation-Domain Technologies Based on Synthesis of Optical Coherence Function as Fiber Optic Nerve Systems for Structural Health Monitoring
Authors: Hotate Kazuo
Published: January 2019

Brillouin optical correlation-domain technologies are reviewed as “fiber optic nerve systems” for the health monitoring of large structures such as buildings, bridges, and aircraft bodies. The Brillouin scattering property is used as a sensing mechanism for strain and/or temperature. Continuous lightwaves are used in the technologies, and their optical coherence properties are synthesized to realize position-selective measurement. This coherence manipulation technology is called the “synthesis of optical coherence function (SOCF)”. By utilizing SOCF technologies, stimulated Brillouin scattering is generated position-selectively along the fiber, which is named “Brillouin optical correlation domain analysis (BOCDA)”. Spontaneous Brillouin scattering, which takes place at any portion along the fiber, can also be measured position-selectively by the SOCF technology. This is called “Brillouin optical correlation domain reflectometry (BOCDR)”. When we use pulsed lightwaves that have the position information, sensing performances, such as the spatial resolution, are inherently restricted due to the Brillouin scattering nature. However, in the correlation-domain technologies, such difficulties can be reduced. Superior performances have been demonstrated as distribution-sensing mechanisms, such as a 1.6-mm high spatial resolution, a fast measurement speed of 5000 points/s, and a 7000-με strain dynamic range, individually. The total performance of the technologies is also discussed in this paper. A significant feature of the technologies is their random accessibility to discrete multiple points that are selected arbitrarily along the fiber, which is not realized by the time domain pulsed-lightwave technologies. Discriminative and distributed strain/temperature measurements have also been realized using both the BOCDA technology and Brillouin dynamic grating (BDG) phenomenon, which are associated with the stimulated Brillouin scattering process. In this paper, the principles, functions, and applications of the SOCF, BOCDA, BOCDR, and BDG-BOCDA systems are reviewed, and their historical aspects are also discussed.
Regularization Factor Selection Method for l1-Regularized RLS and Its Modification against Uncertainty in the Regularization Factor
Authors: Lim Junseok , Lee Seokjin
Published: January 2019

This paper presents a new l1-RLS method to estimate a sparse impulse response estimation. A new regularization factor calculation method is proposed for l1-RLS that requires no information of the true channel response in advance. In addition, we also derive a new model to compensate for uncertainty in the regularization factor. The results of the estimation for many different kinds of sparse impulse responses show that the proposed method without a priori channel information is comparable to the conventional method with a priori channel information.
Subirrigation Effects on Larch Seedling Growth, Root Morphology, and Media Chemistry
Authors: Wan Fangfang , Ross-Davis Amy L. , Shi Wenhui , Weston Christopher , Song Xiehai , Chang Xiaochao , Davis Anthony S. , Liu Yong , Teng Fei
Published: January 2019

Subirrigation (SI), where water is provided to container seedlings from below and rises through the growing media via capillary action, is regarded as an environmentally-responsible method of delivering water and fertilizer to nursery-grown plants, resulting in more uniform crops and improved production efficiency. While a concern around adopting this method is that a potential higher salt concentration in the upper layers of growing media under SI may inhibit root growth and result in decreased plant quality, few studies have focused on how root morphology is altered by SI. Therefore, a balanced two-factor factorial design with three rates of fertilization (50, 100, and 150 mg N seedling−1) and two irrigation methods (SI or overhead irrigation (OI)) was used to examine the growth response of Prince Rupprecht’s larch (Larix principis-rupprechtii Mayr) seedlings for one nursery season. Associated changes between rhizosphere electrical conductivity (EC) and root morphology of different root size classes were analyzed. Results show that (1) height, root-collar diameter, and root volume were similar between seedlings grown under SI and OI. However, (2) compared to seedlings receiving OI, SI-seedlings had less root mass, length, and surface area but greater average root diameter (ARD). (3) Morphological differences were evident primarily in root diameter size classes I–III (D ≤ 1.0 mm). (4) Fertilizer rate influenced root length and surface area up to 130 days after sowing but affected ARD throughout the growing season such that seedlings treated with 50 mg N had smaller ARD than seedlings treated with 100 mg N. (5) As the growing season progressed, SI-media had significantly higher EC compared to OI-media and EC increased with increasing fertilizer rate under SI but not under OI. These results indicate that SI can produce larch seedlings of similar height and root collar diameter (RCD) compared to OI, but root systems are smaller overall with fewer small-diameter roots, which may be related to high EC levels in SI-media, which is exacerbated by the use of high rates of fertilizer. Therefore, the EC in the media should be monitored and adjusted by reducing fertilizer rates under SI.
Acknowledgement to Reviewers of Games in 2018
Authors:   Games Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Genetic Dissection of Grain Nutritional Traits and Leaf Blight Resistance in Rice
Authors: Descalsota-Empleo Gwen Iris , Noraziyah Abd Aziz Shamsudin , Navea Ian Paul , Chung Chongtae , Dwiyanti Maria Stefanie , Labios Reuben Jacob Dicen , Ikmal Asmuni Mohd , Juanillas Venice Margarette , Inabangan-Asilo Mary Ann , Amparado Amery , Reinke Russell , Cruz Casiana M. Vera , Chin Joong Hyoun , Swamy B.P. Mallikarjuna
Published: January 2019

Colored rice is rich in nutrition and also a good source of valuable genes/quantitative trait loci (QTL) for nutrition, grain quality, and pest and disease resistance traits for use in rice breeding. Genome-wide association analysis using high-density single nucleotide polymorphism (SNP) is useful in precisely detecting QTLs and genes. We carried out genome-wide association analysis in 152 colored rice accessions, using 22,112 SNPs to map QTLs for nutritional, agronomic, and bacterial leaf blight (BLB) resistance traits. Wide variations and normal frequency distributions were observed for most of the traits except anthocyanin content and BLB resistance. The structural and principal component analysis revealed two subgroups. The linkage disequilibrium (LD) analysis showed 74.3% of the marker pairs in complete LD, with an average LD distance of 1000 kb and, interestingly, 36% of the LD pairs were less than 5 Kb, indicating high recombination in the panel. In total, 57 QTLs were identified for ten traits at p < 0.0001, and the phenotypic variance explained (PVE) by these QTLs varied from 9% to 18%. Interestingly, 30 (53%) QTLs were co-located with known or functionally-related genes. Some of the important candidate genes for grain Zinc (Zn) and BLB resistance were OsHMA9, OsMAPK6, OsNRAMP7, OsMADS13, and OsZFP252, and Xa1, Xa3, xa5, xa13 and xa26, respectively. Red rice genotype, Sayllebon, which is high in both Zn and anthocyanin content, could be a valuable material for a breeding program for nutritious rice. Overall, the QTLs identified in our study can be used for QTL pyramiding as well as genomic selection. Some of the novel QTLs can be further validated by fine mapping and functional characterization. The results show that pigmented rice is a valuable resource for mineral elements and antioxidant compounds; it can also provide novel alleles for disease resistance as well as for yield component traits. Therefore, large opportunities exist to further explore and exploit more colored rice accessions for use in breeding.
DEMMI Scores, Length of Stay, and 30-Day Readmission of Acute Geriatric Patients in Denmark: A Cross-Sectional Observational Study with Longitudinal Follow-Up
Authors: Melgaard Dorte , Rodrigo-Domingo Maria , Mørch Marianne M. , Byrgesen Stephanie M.
Published: January 2019

The aims of this study are to describe the mobility of acute geriatric patients, the length of stay, and to characterise patients who were readmitted within 30 days based on the De Morton Mobility Index (DEMMI). A cross-sectional observational study with longitudinal follow-up was conducted in the period from 1 March 2016 to 31 August 2016. Inclusion criteria were acute geriatric patients hospitalised for a minimum of 24 h. Of the 418 patients hospitalised during the study period, 246 (59%) participated in this study (44% male, median age 83 years [70; 94]). For patients in an acute geriatric department, the median DEMMI score was 41 and the mean score was 39.95. Patients with a DEMMI score ≤40 show a significantly lower Barthel 100 index, lower 30 s. sit-to-stand scores and were significantly more likely to be bedridden or, amongst those not bedridden, to use a mobility aid. Lower DEMMI scores were associated with longer admissions. DEMMI seems to have the ability to predict discharge within one week. There was no significant association between a lower DEMMI score and higher risk for 30-day readmission. Further research is needed to determine whether the DEMMI is suitable for identifying the patient’s need for further rehabilitation following the discharge.
Is There an Association between Physical Activity and Sleep in Community-Dwelling Persons with Dementia: An Exploratory Study Using Self-Reported Measures?
Authors: Bartfay Emma , Stewart Paige , Bartfay Wally , Papaconstantinou Efrosini
Published: January 2019

Sleep disturbances are common in persons with dementia (PWD). While pharmacotherapy is widely used, non-pharmacological interventions are beginning to surface as first-line management strategies. This study sought to investigate if physical activity was associated with more favourable sleep patterns in PWD, and to compare the sleep quantity and quality between active and inactive PWD. We conducted an exploratory study to tackle these research questions. Self-reported telephone questionnaires were administered to 40 caregivers of PWD, who answered questions as proxies on behalf of their care recipient. Just over half (55%) of our participants met the criteria for being active. Walking was the most popular form of physical activity for both active and inactive PWD. Active PWD also preferred exercise classes and gardening, whereas inactive PWD favoured chair exercises. Compared to their inactive counterparts, active PWD were more likely to experience appropriate sleep quantity (p = 0.00). The active group also reported significantly better overall sleep quality (p = 0.003). Together, our findings suggest that physical activity may be associated with improved sleep in PWD. Future studies are warranted to investigate whether physical activity can be promoted as a safe and effective means to improve quality-of-life in this population.
Implementation of Quiet Areas in Sweden
Authors: Cerwén Gunnar , Mossberg Frans
Published: January 2019

The notion of quiet areas has received increasing attention within the EU in recent years. The EU Environmental Noise Directive (END) of 2002 stipulates that member states should map existing quiet areas and formulate strategies to keep these quiet. Quiet areas could play an important role in balancing densified urban development by ensuring access to relative quietness and associated health benefits. This paper reports on a recent study investigating how the notion of quiet areas has been implemented in Sweden. The study, initiated by the Sound Environment Center in 2017, was carried out in two phases. In phase one, an overview of the current situation was obtained by scrutinizing regional and municipal mapping initiatives, aided by a short digital questionnaire sent out to all 290 municipalities in Sweden. This provided a general understanding and highlighted initiatives for further study in phase two. The results revealed that 41% (n = 118) of Sweden’s municipalities include quiet areas in their general plans, but that significantly fewer of these have sophisticated strategies for implementation (n = 16; 6%). Moreover, the interest in quiet areas in municipalities does not seem to be directly related to the END, but is instead inspired by previous regional initiatives in Sweden. The study highlights a number of considerations and examples of how quiet areas are approached in Sweden today. In general, Sweden has come a long way in terms of identifying and mapping quiet areas, but more progress is needed in developing strategies to protect, maintain, and publicize quiet areas.
Elimination of Schistosoma japonicum Transmission in China: A Case of Schistosomiasis Control in the Severe Epidemic Area of Anhui Province
Authors: Li Linhan , Zhou Yibiao , Wang Tianping , Zhang Shiqing , Chen Gengxin , Zhao Genming , He Na , Zhang Zhijie , Yang Dongjian , Yang Ya , Yang Yu , Yuan Hongchang , Chen Yue , Jiang Qingwu
Published: January 2019

Over the several decades, China has been incessantly optimizing control strategies in response to the varying epidemic situations of schistosomiasis. We evaluated continuously the changing prevalence under different control strategies of two villages, Sanlian and Guifan, in China through five phases lasting 37 years. We tested residents, calculated prevalence and discussed change causes. We found the prevalence in Sanlian did not differ significant from that of Guifan (p = 0.18) in 1981, but decreased to 2.66%, much lower than Guifan’s 11.25%, in 1984 (p = 0). Besides, prevalence in Guifan increased to 21.25% in 1987, while in Sanlian it rose to 20.78% until 1989. Those data confirmed that praziquantel combined with snail control could better reduce the prevalence. From 1992 to 1994, the prevalence in the two villages displayed downtrends, which showed the World Bank Loan Project worked. From 1995 to 2004, repeated oscillations with no obvious change trend was seen. Since 2005, the prevalence in both villages has shown a significant downtrend (p < 0.05), which suggests the integrated strategy is effective. We considered the control strategies were implemented suitably in the study area under changing social circumstances. Adjusting the strategy in consideration of social transformations is necessary and vital. The experience may be useful for policy making of other epidemic areas with an analogous situation.
Trends in Workplace Injuries in Slovak Forest Enterprises
Authors: Gejdoš Miloš , Vlčková Mária , Allmanová Zuzana , Balážová Žaneta
Published: January 2019

The aim of the paper is to analyse the effect of key factors affecting the risk of workplace injuries and to identify the most common workplace accidents regarding injured body parts with respect to anthropometric data measurements of the population. Data associated with workplace accidents over the years 2000–2016 were drawn from the records of the state enterprise Forests of the Slovak Republic, situated in Banská Bystrica. Gathered data were processed and entered into the database complemented by the data on accidents of the self-employed working in the forestry industry. A total of 1874 workplace accidents in the state enterprise were recorded and statistically evaluated during the analysis period. A method for contingency table was used to analyse correlation between qualitative (categorical) variables in the dataset. A Poisson regression model was used to determine the injury rate. Forest harvesting is considered the most risky phase of the process of harvesting, processing, and transport. The highest number of workplace accidents (31.8% of all recorded workplace accidents) occurred during the forest harvesting phase during the analysis period. Timber skidding, with 16% of recorded accidents, was the second highest-risk phase. The workplace injury rate in the forest industry in Slovakia decreased over the course of the years 2000–2016. Head and facial injuries were those with the highest rate (67.1% injuries of these body parts) during the phase of harvesting and skidding.
Corticosteroids in Moderate-To-Severe Graves’ Ophthalmopathy: Oral or Intravenous Therapy?
Authors: Penta Laura , Muzi Giulia , Cofini Marta , Leonardi Alberto , Lanciotti Lucia , Esposito Susanna
Published: January 2019

Background: Ophthalmopathy is a rare extra-thyroid manifestation of Graves’ disease, in paediatrics. Intravenous corticosteroids are the main treatment of moderate-to-severe Graves’ orbitopathy. In this paper, we describe a moderate-to-severe active Graves’ ophthalmopathy in a child and the response to oral therapy with prednisone. Case presentation: A nine-year-old male child suffering for a few months, from palpitations, tremors, and paresthesia was hospitalized in our Pediatric Clinic. At admission, the thyroid function laboratory tests showed hyperthyroidism with elevated free thyroxine (FT4) and free triiodothyronine (FT3) levels and suppressed thyroid-stimulating hormone (TSH) levels. These findings, combined with the clinical conditions—an ophthalmologic evaluation (that showed the presence of exophthalmos without lagophthalmos and visual acuity deficiency), thyroid ultrasound, and TSH receptor antibody positivity—led to a diagnosis of Graves’ disease. Therefore, methimazole was administered at a dose of 0.4 mg/kg/day. After 4 months, thyroid function was clearly improved, with normal FT3 and FT4 values and increasing TSH values, without adverse effects. Nevertheless, an eye examination showed ophthalmopathy with signs of activity, an increase in the exophthalmos of the right eye with palpebral retraction, soft tissue involvement (succulent and oedematous eyelids, caruncle and conjunctival hyperaemia and oedema) and keratopathy, resulting from exposure. We began steroid therapy with oral administration of prednisone (1 mg/kg/day) for four weeks, followed by gradual tapering. After one week of therapy with prednisone, an eye assessment showed reduced retraction of the upper eyelid of the right eye, improvement of right eye exophthalmometry and reduction of conjunctival hyperaemia. After four weeks of therapy with prednisone, an eye assessment showed reduction of the right palpebral retraction without conjunctival hyperaemia and no other signs of inflammation of the anterior segment; after twelve weeks, an eye assessment showed a notable decrease in the right palpebral retraction and the absence of keratitis, despite persisting moderate conjunctival hyperaemia. No adverse event associated with steroid use was observed during the treatment period and no problem in compliance was reported. Conclusion: Prednisone seems a better choice than intravenous corticosteroids, for treating moderate-to-severe and active Graves’ ophthalmopathy, keeping in mind the importance of quality of life in pediatric patients.
Cotreatment of MSWI Fly Ash and Granulated Lead Smelting Slag Using a Geopolymer System
Authors: Liu De-Gang , Ke Yong , Min Xiao-Bo , Liang Yan-Jie , Wang Zhong-Bing , Li Yuan-Cheng , Fei Jiang-Chi , Yao Li-Wei , Xu Hui , Jiang Guang-Hua
Published: January 2019

Municipal solid waste incineration fly ash (MSWI FA) and granulated lead smelting slag (GLSS) are toxic industrial wastes. In the present study, granulated lead smelting slag (GLSS) was pretreated as a geopolymer precursor through the high-energy ball milling activation process, which could be used as a geopolymeric solidification/stabilization (S/S) reagent for MSWI FA. The S/S process has been estimated through the physical properties and heavy metals leachability of the S/S matrices. The results show that the compressive strength of the geopolymer matrix reaches 15.32 MPa after curing for 28 days under the best parameters, and the physical properties meet the requirement of MU10 grade fly ash brick. In addition, the toxicity characteristic leaching procedure (TCLP) test results show that arsenic and heavy metals are immobilized effectively in the geopolymer matrix, and their concentrations in the leachate are far below the US EPA TCLP limits. The hydration products of the geopolymer binder are characterized by X-ray diffraction and Fourier transform infrared methods. The results show that the geopolymer gel and Friedel’s salt are the main hydration products. The S/S mechanism of the arsenic and heavy metals in the geopolymer matrix mainly involves physical encapsulation of the geopolymer gel, geopolymer adsorption and ion exchange of Friedel’s salt.
The “Land of Fires” Toxic Waste Scandal and Its Effect on Consumer Food Choices
Authors: Cembalo Luigi , Caso Daniela , Carfora Valentina , Caracciolo Francesco , Lombardi Alessia , Cicia Gianni
Published: January 2019

The present study focused on an environmental scandal that occurred in Italy, the Land of Fires toxic waste scandal, which caused consumer concerns related to the safety of food produced in the affected region, as well as massive market reduction in products associated with the polluted area. Based on a representative sample of Italian households (N = 1134), this study applied an extended Theory of Planned Behavior (TPB) model to analyze consumer purchases of regional food products after this environmental hazard. In addition to attitudes, subjective norms and perceived behavioral control, the model included risk perception, trust, and actual purchases. Using a structural equation model, our results provided support to the hypothesis that consumer perceptions of risk negatively impacted their purchase behaviors and suggested that increasing Italians’ trust in government information could reduce their perceived risk and, consequently, increase their intention to purchase regional food.
The Role of Copper Homeostasis at the Host-Pathogen Axis: From Bacteria to Fungi
Authors: Li Chao , Li Yanjian , Ding Chen
Published: January 2019

Copper is an essential trace element participating in many vital biological processes, however it becomes a toxic agent when in excess. Thus, precise and tight regulation of copper homeostasis processes, including transport, delivery, storage, detoxification, and efflux machineries, is important, ensuring that only the amount needed to sustain basic biological functions and simultaneously prevent copper toxicity in the cell is maintained. Numerous exciting studies have revealed that copper plays an indispensable role at the microbial pathogen-host axis for entities ranging from pathogenic bacteria to deadly fungal species. Analyses of copper homeostases in bacteria and fungi extensively demonstrate that copper is utilized by the host immune system as an anti-microbial agent. The expression of copper efflux and detoxification from microbial pathogens is induced to counteract the host’s copper bombardment, which in turn disrupts these machineries, resulting in the attenuation of microbial survival in host tissue. We hereby review the latest work in copper homeostases in pathogenic bacteria and fungi and focus on the maintenance of a copper balance at the pathogen-host interaction axis.
Comparison between Polybutylcyanoacrylate Nanoparticles with Either Surface-Adsorbed or Encapsulated Brain-Derived Neurotrophic Factor on the Neural Differentiation of iPSCs
Authors: Lin Martin Hsiu-Chu , Chung Chiu-Yen , Chen Kuo-Tai , Yeh Jih-Chao , Lee Tsong-Hai , Lee Ming-Hsueh , Lee I-Neng , Huang Wei-Chao , Yang Jen-Tsung
Published: January 2019

The brain-derived neurotrophic factor (BDNF) is vital in the neural differentiation of neural stem/progenitor cells, and together may have therapeutic potential for neural regeneration. In this study, a multiplexed polybutylcyanoacrylate nanoparticle (PBCA NP) delivery platform was constructed, incorporating either surface-adsorbed or encapsulated BDNF for the induction of neural differentiation in induced pleuripotent stem cells (iPSCs), where tween 80 (T80) and superparamagnetic iron oxide (SPIO) were added for central nervous system (CNS) targeting and magnetic resonance (MR) image tracking, respectively. Both methods by which the BDNF was carried resulted in loading efficiencies greater than 95%. The nanoparticle-mediated delivery of BDNF resulted in neural differentiation of iPSCs detected on immunofluorescence staining as early as 7 days, with enhanced differentiation efficiency by 1.3-fold compared to the control on flow cytometry; the delivery system of surface-adsorbed BDNF gave rise to cells that had the best neural development than the encapsulated formulation. T80-coating disrupted the in vitro blood–brain barrier model with a corresponding 1.5- to two-fold increase in permeability. SPIO-loaded PBCA NPs exhibited a concentration-dependent, rapid decay in signal intensity on the phantom MR experiment. This study demonstrates the versatility of the PBCA NP, and the surface-adsorption of BDNF is the preferred method of delivery for the differentiation of iPSCs.
Bacteriocins and Bacteriophages: Therapeutic Weapons for Gastrointestinal Diseases?
Authors: Lopetuso Loris Riccardo , Giorgio Maria Ernestina , Saviano Angela , Scaldaferri Franco , Gasbarrini Antonio , Cammarota Giovanni
Published: January 2019

Bacteriocins are bactericidal peptides, ribosomally synthesized, with an inhibitory activity against diverse groups of undesirable microorganisms. Bacteriocins are produced by both gram-positive and gram-negative bacteria, and to a lesser extent by some archaea. Bacteriophages are viruses that are able to infect bacterial cells and force them to produce viral components, using a lytic or lysogenic cycle. They constitute a large community in the human gut called the phageome, the most abundant part of the gut virome. Bacteriocins and bacteriophages may have an influence on both human health and diseases, thanks to their ability to modulate the gut microbiota and regulate the competitive relationship among the different microorganisms, strains and cells living in the human intestine. In this review, we explore the role of bacteriocins and bacteriophages in the most frequent gastrointestinal diseases by dissecting their interaction with the complex environment of the human gut, analyzing a possible link with extra-intestinal diseases, and speculating on their possible therapeutic application with the end goal of promoting gut health.
High Expression of IL-1RI and EP2 Receptors in the IL-1β/COX-2 Pathway, and a New Alternative to Non-Steroidal Drugs—Osthole in Inhibition COX-2
Authors: Kordulewska Natalia Karolina , Cieślińska Anna , Fiedorowicz Ewa , Jarmołowska Beata , Kostyra Elżbieta
Published: January 2019

Background: Osthole (7-methoxy-8-isopentenylcoumarin) is natural coumarin isolated from the fruit of Cnidium monnieri (L.) Cusson, which is commonly used in medical practice of traditional Chinese medicine (TCM) in various diseases including allergies and asthma disorders. Purpose: Osthole was tested for the anti-histamine, anti-allergic, and inhibitory effects of COX-2 (cyclooxygenase-2) in children with diagnosed allergies. Additionally, we hypothesize that stated alterations in children with diagnosed allergies including increased expression of interleukin 1-β receptor type 1 (IL-1 type I) and E-prostanoid (EP) 2 receptors, as well as raised expression, production, and activity of COX-2 and IL-1β in incubated medium are approximately connected. Furthermore, we establish the mechanisms included in the changed regulation of the COX-2 pathway and determine whether osthole may be COX-2 inhibitor in peripheral blood mononuclear cells (PBMCs). Method: PBMCs were obtained from peripheral blood of healthy children (control, n = 28) and patients with diagnosed allergies (allergy, n = 30). Expression of the autocrine loop components regulating PGE2 production and signaling namely IL-1 type I receptor (IL-1RI), cyclooksygenaze-2 (COX-2), E-prostanoid (EP) 2, and also histamine receptor-1 (HRH-1) was assessed at baseline and after stimulation with histamine, osthole, and a mixture of histamine/osthole 1:2 (v/v). This comprised the expression of histamine receptor 1 (HRH-1), IL-1RI, COX-2, EP2 receptor, and the secretion of IL-1β and COX-2 in cultured media and sera. Results: Compared with control group, basal mRNA expression levels of HRH-1, IL-1RI, COX-2, and EP2 were higher in the allergy group. Histamine-induced EP2 and COX-2 expression mRNA levels were also increased. Conclusions: Osthole successively inhibits PGE2 and COX-2 mRNA expression. Furthermore, osthole reduces the secretion of COX-2 protein in signaling cellular mechanisms. Changed EP2 expression in children with allergies provides higher IL-1RI induction, increasing IL-1β capacity to increase COX-2 expression. This effects in higher PGE2 production, which in turn increases its capability to induce IL-1RI.
Extracellular Matrix in Development and Disease
Authors: Oxford Julia Thom , Reeck Jonathon C. , Hardy Makenna J.
Published: January 2019

The evolution of multicellular metazoan organisms was marked by the inclusion of an extracellular matrix (ECM), a multicomponent, proteinaceous network between cells that contributes to the spatial arrangement of cells and the resulting tissue organization. [...]
Host-Induced Gene Silencing: A Powerful Strategy to Control Diseases of Wheat and Barley
Authors: Qi Tuo , Guo Jia , Peng Huan , Liu Peng , Kang Zhensheng , Guo Jun
Published: January 2019

Wheat and barley are the most highly produced and consumed grains in the world. Various pathogens—viruses, bacteria, fungi, insect pests, and nematode parasites—are major threats to yield and economic losses. Strategies for the management of disease control mainly depend on resistance or tolerance breeding, chemical control, and biological control. The discoveries of RNA silencing mechanisms provide a transgenic approach for disease management. Host-induced gene silencing (HIGS) employing RNA silencing mechanisms and, specifically, silencing the targets of invading pathogens, has been successfully applied in crop disease prevention. Here, we cover recent studies that indicate that HIGS is a valuable tool to protect wheat and barley from diseases in an environmentally friendly way.
Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration
Authors: Blasiak Janusz , Pawlowska Elzbieta , Szczepanska Joanna , Kaarniranta Kai
Published: January 2019

Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, including defective cellular waste management in retinal pigment epithelium (RPE). Main cellular waste in AMD are: all-trans retinal, drusen and lipofuscin, containing unfolded, damaged and unneeded proteins, which are degraded and recycled in RPE cells by two main machineries—the ubiquitin-proteasome system (UPS) and autophagy. Recent findings show that these systems can act together with a significant role of the EI24 (etoposide-induced protein 2.4 homolog) ubiquitin ligase in their action. On the other hand, E3 ligases are essential in both systems, but E3 is degraded by autophagy. The interplay between UPS and autophagy was targeted in several diseases, including Alzheimer disease. Therefore, cellular waste clearing in AMD should be considered in the context of such interplay rather than either of these systems singly. Aging and oxidative stress, two major AMD risk factors, reduce both UPS and autophagy. In conclusion, molecular mechanisms of UPS and autophagy can be considered as a target in AMD prevention and therapeutic perspective. Further work is needed to identify molecules and effects important for the coordination of action of these two cellular waste management systems.
Translatomics: The Global View of Translation
Authors: Zhao Jing , Qin Bo , Nikolay Rainer , Spahn Christian M. T. , Zhang Gong
Published: January 2019

In all kingdoms of life, proteins are synthesized by ribosomes in a process referred to as translation. The amplitude of translational regulation exceeds the sum of transcription, mRNA degradation and protein degradation. Therefore, it is essential to investigate translation in a global scale. Like the other “omics”-methods, translatomics investigates the totality of the components in the translation process, including but not limited to translating mRNAs, ribosomes, tRNAs, regulatory RNAs and nascent polypeptide chains. Technical advances in recent years have brought breakthroughs in the investigation of these components at global scale, both for their composition and dynamics. These methods have been applied in a rapidly increasing number of studies to reveal multifaceted aspects of translation control. The process of translation is not restricted to the conversion of mRNA coding sequences into polypeptide chains, it also controls the composition of the proteome in a delicate and responsive way. Therefore, translatomics has extended its unique and innovative power to many fields including proteomics, cancer research, bacterial stress response, biological rhythmicity and plant biology. Rational design in translation can enhance recombinant protein production for thousands of times. This brief review summarizes the main state-of-the-art methods of translatomics, highlights recent discoveries made in this field and introduces applications of translatomics on basic biological and biomedical research.
Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy
Authors: Nomoto Haruka , Takami Akiyoshi , Espinoza J. Luis , Onizuka Makoto , Kashiwase Koichi , Morishima Yasuo , Fukuda Takahiro , Kodera Yoshihisa , Doki Noriko , Miyamura Koichi , Mori Takehiko , Nakao Shinji , Morishita Eriko
Published: January 2019

Relapse remains a major obstacle to the survival of patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation. A disintegrin-like and metalloprotease with a thrombospondin type 1 motif (ADMATS13), which cleaves von Willebrand factor multimers into less active fragments, is encoded by the ADAMTS13 gene and has a functional single-nucleotide polymorphism (SNP) rs2285489 (C > T). We retrospectively examined whether ADAMTS13 rs2285489 affected the transplant outcomes in a cohort of 281 patients who underwent unrelated human leukocyte antigen (HLA)-matched bone marrow transplantation for hematologic malignancies. The recipient ADAMTS13 C/C genotype, which putatively has low inducibility, was associated with an increased relapse rate (hazard ratio [HR], 3.12; 95% confidence interval [CI], 1.25–7.77; P = 0.015), resulting in a lower disease-free survival rate in the patients with a recipient C/C genotype (HR, 1.64; 95% CI, 1.01–2.67; P = 0.045). Therefore, ADAMTS13 rs2285489 genotyping in transplant recipients may be a useful tool for evaluating pretransplantation risks.
Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy
Authors: Reddy Sandesh , Younus Iyan , Sridhar Vidya , Reddy Doodipala
Published: January 2019

This article provides an overview of neuroimaging biomarkers in experimental epileptogenesis and refractory epilepsy. Neuroimaging represents a gold standard and clinically translatable technique to identify neuropathological changes in epileptogenesis and longitudinally monitor its progression after a precipitating injury. Neuroimaging studies, along with molecular studies from animal models, have greatly improved our understanding of the neuropathology of epilepsy, such as the hallmark hippocampus sclerosis. Animal models are effective for differentiating the different stages of epileptogenesis. Neuroimaging in experimental epilepsy provides unique information about anatomic, functional, and metabolic alterations linked to epileptogenesis. Recently, several in vivo biomarkers for epileptogenesis have been investigated for characterizing neuronal loss, inflammation, blood-brain barrier alterations, changes in neurotransmitter density, neurovascular coupling, cerebral blood flow and volume, network connectivity, and metabolic activity in the brain. Magnetic resonance imaging (MRI) is a sensitive method for detecting structural and functional changes in the brain, especially to identify region-specific neuronal damage patterns in epilepsy. Positron emission tomography (PET) and single-photon emission computerized tomography are helpful to elucidate key functional alterations, especially in areas of brain metabolism and molecular patterns, and can help monitor pathology of epileptic disorders. Multimodal procedures such as PET-MRI integrated systems are desired for refractory epilepsy. Validated biomarkers are warranted for early identification of people at risk for epilepsy and monitoring of the progression of medical interventions.
Unique Biological Activity and Potential Role of Monomeric Laminin-γ2 as a Novel Biomarker for Hepatocellular Carcinoma: A Review
Authors: Yasuda Hiroshi , Nakagawa Masatoshi , Kiyokawa Hirofumi , Yoshida Eisaku , Yoshimura Toru , Koshikawa Naohiko , Itoh Fumio , Seiki Motoharu
Published: January 2019

Laminin (Ln)-332 consists of α3, β3, and γ2 chains, which mediate epithelial cell adhesion to the basement membrane. Ln-γ2, a component of Ln-332, is frequently expressed as a monomer in the invasion front of several types of malignant tissues without simultaneous expression of Ln-α3 and/or Ln-β3 chains. Moreover, monomeric Ln-γ2 induces tumor cell proliferation and migration in vitro. These unique biological activities indicate that monomeric Ln-γ2 could be a candidate biomarker for early cancer surveillance. However, the present immune method for monomeric Ln-γ2 detection can only predict its expression, since no antibody that specifically reacts with monomeric γ2, but not with heterotrimeric γ2 chain, is commercially available. We have, therefore, developed monoclonal antibodies to specifically detect monomeric Ln-γ2, and devised a highly sensitive method to measure serum monomeric Ln-γ2 levels using a fully automated chemiluminescent immunoassay (CLIA). We evaluated its diagnostic value in sera from patients with several digestive cancers, including hepatocellular carcinoma (HCC), and found serum monomeric Ln-γ2 to be a clinically available biomarker for HCC surveillance. The combination of monomeric Ln-γ2 and prothrombin induced by Vitamin K Absence II (PIVKA-II) may be more sensitive for clinical diagnosis of HCC than any currently used combination.
Relapse of Acute Myeloid Leukemia after Allogeneic Stem Cell Transplantation: Prevention, Detection, and Treatment
Authors: Rautenberg Christina , Germing Ulrich , Haas Rainer , Kobbe Guido , Schroeder Thomas
Published: January 2019

Acute myeloid leukemia (AML) is a phenotypically and prognostically heterogeneous hematopoietic stem cell disease that may be cured in eligible patients with intensive chemotherapy and/or allogeneic stem cell transplantation (allo-SCT). Tremendous advances in sequencing technologies have revealed a large amount of molecular information which has markedly improved our understanding of the underlying pathophysiology and enables a better classification and risk estimation. Furthermore, with the approval of the FMS-like tyrosine kinase 3 (FLT3) inhibitor Midostaurin a first targeted therapy has been introduced into the first-line therapy of younger patients with FLT3-mutated AML and several other small molecules targeting molecular alterations such as isocitrate dehydrogenase (IDH) mutations or the anti-apoptotic b-cell lymphoma 2 (BCL-2) protein are currently under investigation. Despite these advances, many patients will have to undergo allo-SCT during the course of disease and depending on disease and risk status up to half of them will finally relapse after transplant. Here we review the current knowledge about the molecular landscape of AML and how this can be employed to prevent, detect and treat relapse of AML after allo-SCT.
An Improved Reversible Image Transformation Using K-Means Clustering and Block Patching
Authors: Zhong Haidong , Chen Xianyi , Tian Qinglong
Published: January 2019

Recently, reversible image transformation (RIT) technology has attracted considerable attention because it is able not only to generate stego-images that look similar to target images of the same size, but also to recover the secret image losslessly. Therefore, it is very useful in image privacy protection and reversible data hiding in encrypted images. However, the amount of accessorial information, for recording the transformation parameters, is very large in the traditional RIT method, which results in an abrupt degradation of the stego-image quality. In this paper, an improved RIT method for reducing the auxiliary information is proposed. Firstly, we divide secret and target images into non-overlapping blocks, and classify these blocks into K classes by using the K-means clustering method. Secondly, we match blocks in the last (K-T)-classes using the traditional RIT method for a threshold T, in which the secret and target blocks are paired with the same compound index. Thirdly, the accessorial information (AI) produced by the matching can be represented as a secret segment, and the secret segment can be hided by patching blocks in the first T-classes. Experimental results show that the proposed strategy can reduce the AI and improve the stego-image quality effectively.
Laser Cutting: A Review on the Influence of Assist Gas
Authors: Riveiro Antonio , Quintero Félix , Boutinguiza Mohamed , Del Val Jesús , Comesaña Rafael , Lusquiños Fernando , Pou Juan
Published: January 2019

Assist gas plays a central role in laser fusion cutting. In this work, the aerodynamic interactions between the assist gas and the workpiece are reviewed. An insight into those phenomena that hinder the cutting quality and performance is provided. These phenomena include shock waves, choking, boundary layer separation, etc. The most relevant and promising attempts to overcome these common problems related to the gas dynamics are surveyed. The review of the current scientific literature has revealed some gaps in the current knowledge of the role of the assist gas dynamics in laser cutting. The assist gas interactions have been investigated only under static conditions; and the dynamic interaction with the molten material on the cutting front has not been addressed. New nozzle designs with improved efficiency of molten material removal are required to improve cut quality; and cutting speed in current industrial laser cutting machines; especially in those assisted by new high-brightness laser sources.
Erratum: Il’ina, M.V.; et. al. Piezoelectric Response of Multi-Walled Carbon Nanotubes. Materials 2018, 11, 638
Authors:   Materials Editorial Office
Published: January 2019

The Materials Editorial Office would like to report errors in the published paper [...]
Effect of Two-Step Austempering Process on Transformation Kinetics of Nanostructured Bainitic Steel
Authors: Chu Chunhe , Qin Yuman , Li Xuemei , Yang Zhinan , Zhang Fucheng , Guo Changhong , Long Xiaoyan , You Leilei
Published: January 2019

The two-step austempering process has been reported to be an effective method to accelerate the bainitic transformation process by introducing martensite (Q-M-B). However, in this study, it was found that the Q-M-B process reduced the incubation time, but the transformation duration remained nearly unchanged. The notably reduced activation energy barrier for nucleation of bainitic ferrite on the preformed martensite should be responsible for the reduced duration time of the Q-M-B process. A process that both of the two steps were above, Ms (Q-B-B), has been demonstrated to increase transformation rate and improve the amount of bainitic ferrite, which probably results from the additional hysteresis free energy provided by the first quenching process.
Design of an Integrated Optics Sensor Structure Based on Diamond Waveguide for Hemoglobin Property Detection
Authors: Struk Przemysław
Published: January 2019

This manuscript presents a theoretical analysis of a diamond-based integrated optics structure for applications in biosensors. The geometrical, optical, and sensitivity properties of an integrated optical structure were theoretically analyzed and optimized for biosensor applications. The analysis focused on determining the waveguide properties, including the effective refractive index Neff as a function of refractive index nw and thickness dw of waveguide layer, refractive index of the hemoglobin cover layer ncH and substrate layer ns, homogeneous sensitivity dNeff/dncH, and modal field distribution of guided waveguide modes. The analysis was completed for two types of waveguide layer materials: undoped or boron-doped diamond films with or without the hemoglobin cover layer. The presented experimental results form a base for developing biosensor structures based on integrated optics for determining the properties of hemoglobin.
Perspective on Plasma Polymers for Applied Biomaterials Nanoengineering and the Recent Rise of Oxazolines
Authors: Macgregor Melanie , Vasilev Krasimir
Published: January 2019

Plasma polymers are unconventional organic thin films which only partially share the properties traditionally attributed to polymeric materials. For instance, they do not consist of repeating monomer units but rather present a highly crosslinked structure resembling the chemistry of the precursor used for deposition. Due to the complex nature of the deposition process, plasma polymers have historically been produced with little control over the chemistry of the plasma phase which is still poorly understood. Yet, plasma polymer research is thriving, in par with the commercialisation of innumerable products using this technology, in fields ranging from biomedical to green energy industries. Here, we briefly summarise the principles at the basis of plasma deposition and highlight recent progress made in understanding the unique chemistry and reactivity of these films. We then demonstrate how carefully designed plasma polymer films can serve the purpose of fundamental research and biomedical applications. We finish the review with a focus on a relatively new class of plasma polymers which are derived from oxazoline-based precursors. This type of coating has attracted significant attention recently due to its unique properties.