bluuebunny/crossref_metadata_2025 huggingface dataset:
Una mayor empatía al VIH/SIDA a través de la educomunicación = A greater empathy for HIV/AIDS through educommunication
Authors: Grande-López Víctor
Published: June 2019

Desde el inicio del VIH/sida en los años 80, el relato audiovisual no sólo ha servido para situar al espectador en un contexto social sino que le ha ayudado a reflexionar sobre la epidemia más devastadora de la medicina contemporánea. El miedo y el desconocimiento han fomentado procesos de discriminación provocando que personas con VIH/sida no sean tratadas con dignidad y respeto. Desde el ámbito de la educomunicación como vehículo de transmisión de conocimientos a través del medio, se pretende como objetivo principal concienciar sobre la importancia de la prevención del VIH/sida a la generación Z, los primeros adolescentes del siglo XXI. Para ello, se presenta una metodología: mediante una propuesta edu-inclusiva con pequeñas píldoras audiovisuales de la serie de televisión Élite (2018) y a través de la teoría ecológica de Bronfenbrenner sobre cómo influye en el desarrollo cognitivo y conductual los ambientes que rodean a una persona. Dando como resultados un impacto a nivel sensorial, actuando como transformador de conciencia saludable y logrando subsanar prejuicios y heridas sociales. Se concluye que es esencial trabajar sobre VIH/sida desde edades tempranas, ya que más vale comunicar para prevenir que callar para curar.Palabras clave: cine; VIH/sida; adolescentes; educación para la salud; series tv.; comunicación.Abstract Since the beginning of HIV/AIDS in the 1980s, the audiovisual story hasn´t only served to situate the viewer in a social context but it has helped him to reflect on the most devastating epidemic of contemporary medi­cine. Fear and ignorance have fostered discrimination processes causing people with HIV/AIDS not to be treated with dignity and respect. From the field of educommunication as a vehicle for the transmission of knowledge through the media, the main objective is to raise awareness of the importance of HIV/AIDS pre­vention to Generation Z, the first teenagers of the 21st century. Because of this, it is presented a methodo­logy through an edu-inclusive proposal with small audiovisual pills from the TV series Élite (2018) and through Bronfenbrenner´s ecological systems theory about how the environments that surround a person can influence cognitive and behavioural development. As a result there is an impact at sensory level, acting as a healthy conscience transformer and managing to correct prejudices and social wounds. In conclusion: it´s essential to work on HIV/AIDS from an early age, because it´s better to communicate to prevent than be silent in order to heal.Keywords: cinema; HIV/AIDS; teenagers; education for the health; TV series; communication.
Life Writing Therapy Decreases Depression in Late Adolescence
Authors: Istiqomah Zulaikah Nur , Erawati Erna , Suyanta Suyanta
Published: June 2019

Introduction: Late adolescence (16-18 years old) usually experiences a crucial period in life which makes teenagers vulnerable to mood disorders such as depression. One of the interventions that can decrease depression is writing a memoir, biography, diary, and life writing. Writing can disclose the feeling and help mind care. The objective of this study was to investigate the influence of life writing therapy to decrease depression in late adolescence.Methods: This study used pretest-post-test control group design with 40 people as samples, divided into intervention and control groups. Before and after the treatment, both groups were measured using the scale of the PHQ-9A to see the depression in late adolescence of high school students.Results: Life writing therapy shows differences in mean between intervention group and control group with a p-value of 0.000 (α <0.05).Conclusion: The life writing therapy has an effect in reducing depression in students. It facilitates subjects to evaluate, analyze, and reassess past, current and future events so that subjects can get an understanding, develop a solution and self-motivation, accept the existing situation, learn from what is experienced, focus thoughts on positive things, and assess positive things from an event.
Improving Self-Protection Knowledge Against Sexual Abuse by Using Dreall Healthy and Animation Video
Authors: Pradita Adelia , Kusumaningrum Arie , Natosba Jum
Published: June 2019

Introduction: The number of child sexual abuse cases in Indonesia are still high, including in Ogan Komering Ilir Regency, South Sumatera. One of the preventive effort that can be practiced is teaching them about children self-protection knowledge from sexual abuse through sexual education using appropriate methods and media, such as watching animated video and dreall healthy. The aim of this research was to determine difference in dreall healthy and animated video about sexual education toward children self-protection knowledge from sexual abuse.Methods: This research was a quantitative study and use quasi experiment design with pretest-postest group. Samples in this research were 40 children in dreall healthy group and 37 children in the animated video group, the samples were taken using purposive sampling technique. The data were collected by using questionnaire and data analysis was using paired t test and independent t test.Results: This research showed that there was  difference in children self-protection knowledge from sexual abuse before and after sexual education with dreall healthy and animated video with p value 0.000 (α ≤0.05) and there was difference in children self-protection knowledge from sexual abuse between dreall healthy and animated video with p value 0.014 (α ≤0.05).Conclusion: Sexual education with dreall healthy is more effective to increase children self-protection knowledge because it can stimulate the children’s brain nerves so that their memory could be better. It was expected that parents, public health center staffs, and counselor in schools be able to provide sexual education as early as possible to the children.
The Correlation Between Motivation and Health Locus of Control with Adherence Dietary of Diabetes Mellitus
Authors: Kusnanto Kusnanto , Susanti Retno Dwi , Ni'mah Lailatun , Zulkarnain Hakim
Published: June 2019

Introduction: Controlling blood sugar can be done by dietary adherence of DM. To control glycemic, it is necessary to have motivation and health locus of control to face boredom in dietary adherence of DM. The aim was to analyse the correlation between motivation and health locus of control with dietary adherence of DM.Methods: Cross-sectional design was conducted and involved 106 respondents from five public health centers in Surabaya selected by random sampling. Data were collected by questionnaire Treatment Self-Regulation Questionnaire (TSRQ), Multidimensional Health Locus of Control Scales” (MHLC), and Diet Adherence. The analysis data was using statistical Spearman rho (α ≤ 0.05).Results: There was no correlation between motivation and dietary adherence (p=0.178), and there was a correlation between health locus of control with dietary adherence (p = 0.002).Conclusion: According to analysis, it can be concluded that motivation is influenced by many things to the role the forming of patient behavior in dietary adherence of DM while health locus of control has an influence to dietary adherence of DM. Because of that, it is necessary to increase the factor that influences the behavior of DM control. One of it is health locus of control. So that the glycemic control with dietary adherence of DM can increase and be better.
DÜNYA’DA VE TÜRKİYE’DE KARBON TİCARETİ VE KARBON MUHASEBESİ UYGULAMALARI ÜZERİNE BİR ARAŞTIRMA - A RESEARCH ON CARBON TRADE AND CARBON ACCOUNTING APPLICATIONS IN THE WORLD AND TURKEY
Authors: GÜRBÜZ Cennet , ARACI Özlem Nilüfer Karataş , BEKCİ İsmail
Published: June 2019

Sanayi devriminden bu yana, küreselleşmeyle birlikte hızla gelişen sanayi ve ticaret daha fazla doğal kaynak ve enerji ihtiyacını beraberinde getirmiştir. Bu ihtiyaçlar karşılanırken birçok ekolojik problem ortaya çıkmıştır. Bunlardan en vahimi küresel ısınmaya bağlı olarak iklim değişikliğidir. İklim değişikliğinin en önemli sebebi sera gazı emisyonlarının atmosferde birikmesidir. Dolayısıyla iklim değişikliği ve küresel ısınmanın önüne geçebilmek için başvurulabilecek mücadele yöntemlerinden en önemlisi, bu gazların emisyonlarının azaltılmasıdır. Bu bağlamda, mücadelenin uluslararası boyutta yapılabilmesi için bazı anlaşmalar imzalanmaktadır. Bu anlaşmaların sonuçlarından bir tanesi karbon ticaretidir. Bu ticaret, işletmelerin karbon emisyonlarının ölçülmesi, kayıt altına alınması, finansal raporlarda yer alması ve ayrıca maliyetlerinin hesaplanması ve kontrol edilmesi ihtiyaçlarını doğurmuştur. Böylelikle karbon muhasebesi ortaya çıkmıştır. Bu çalışmada Dünya’da ve Türkiye’de karbon ticaretinin boyutları ele alınmış ve karbon muhasebesinde yer alan farklı uygulamalar örneklerle açıklanmıştır.
Predicting Motor Insurance Claims Using Telematics Data—XGBoost vs. Logistic Regression
Authors: Pesantez-Narvaez Jessica , Guillen Montserrat , Alcañiz Manuela
Published: June 2019

XGBoost is recognized as an algorithm with exceptional predictive capacity. Models for a binary response indicating the existence of accident claims vs. no claims can be used to identify the determinants of traffic accidents. We compare the relative performances of logistic regression and XGBoost approaches for predicting the existence of accident claims using telematics data. The dataset contains information from an insurance company about individuals’ driving patterns – including total annual distance driven and percentage of total distance driven in urban areas. Our findings show that logistic regression is a suitable model given its interpretability and good predictive capacity. XGBoost requires numerous model-tuning procedures to match the predictive performance of the logistic regression model and greater effort as regards interpretation.
The Endocannabinoid System of Animals
Authors: Silver Robert
Published: June 2019

The endocannabinoid system has been found to be pervasive in mammalian species. It has also been described in invertebrate species primitive as the Hydra. Insects apparently are devoid of this otherwise ubiquitous system that provides homeostatic balance to the nervous and immune systems, as well as many other organ systems. The endocannabinoid system (ECS) has been defined to consist of three parts: 1. Endogenous ligands, 2. G-protein coupled receptors (GPCRs), and 3. Enzymes to degrade and recycle the ligands. Two endogenous molecules have been identified as ligands in the ECS to date. These are the endocannabinoids: Anandamide (arachidonoyl ethanolamide) and 2-AG (2-arachidonoyl glycerol). Two G-coupled protein receptors have been described as part of this system, with other putative GPC being considered. Coincidentally, the phytochemicals produced in large quantities by the Cannabis sativa L plant, and in lesser amounts by other plants, can interact with this system as ligands. These plant-based cannabinoids are termed, phytocannabinoids. The precise determination of the distribution of cannabinoid receptors in animal species is an ongoing project, with the canine cannabinoid receptor distribution currently receiving the most interest in non-human animals.
ThriveNYC: Delivering on Mental Health
Authors: Belkin Gary , McCray Chirlane
Published: June 2019

Promoting population mental health and meeting the burdens of mental illness is a priority public health challenge of the 21st century. But too little attention has been placed on how to design and sustain the scope of strategies and commitments that credibly live up to the full breadth of that challenge.

ThriveNYC is an effort by New York City to fill that gap, through a public health approach backed by investment in resources and leadership.

ThriveNYC can by example help mobilize a larger community of investigators and policymakers to consider how to meet this challenge, to get to consensus on key elements for effective action and implementation, to reimagine who and what the mental health “system” includes, and, in doing so, to strengthen the social contract that underlies well-being.
Two-Year Changes in Neighborhood Juvenile Arrests After Implementation of a Park-Based Afterschool Mental Health Promotion Program in Miami–Dade County, Florida, 2015–2017
Authors: D’Agostino Emily M. , Frazier Stacy L. , Hansen Eric , Patel Hersila H. , Ahmed Zafar , Okeke Deidre , Nardi Maria I. , Messiah Sarah E.
Published: June 2019

Objectives. To examine the association of Fit2Lead, an afterschool park-based youth mental health promotion program, and neighborhood juvenile arrests (2015–2017) in Miami–Dade County, Florida.

Methods. We tracked juvenile (ages 12–17 years) arrest rates over 2 years of program implementation across zip codes matched by (1) park and (2) baseline sociodemographics and youth arrests. Fit2Lead mental and physical health, meditation, resilience, and life skills activities were offered in 12 high-need areas for youths (n = 501) aged 12 to 17 years. We tested the association of Fit2Lead implementation (binary variable) and change in juvenile arrest rates by zip code, adjusting for area-level gender, age, race/ethnicity, single-parent households, and poverty.

Results. Fit2Lead was offered in areas composed of 48% male youths, 60% Hispanics, 29% non-Hispanic Blacks, 33% single-parent households, and 33% of residents living in poverty. After covariate adjustment, zip codes with Fit2Lead implementation showed a significant mean reduction (P < .001) in youth arrests per 10 000 youths aged 12 to 17 years per year compared with zip codes without program implementation (b = −6.9; 95% confidence interval = −9.21, −4.65).

Conclusions. Park-based programs may have the potential to promote mental health and resilience, and also to prevent violence among at-risk youths.
Ocular findings in Universal Eye Screening of healthy, full-term newborn infant in Jakarta. The incidence and its risk factors: an observational study
Authors: Sitorus Rita S , Pambudy Indra Maharddhika , Rohsiswatmo Rinawati , Barliana Julie Dewi , Yulia Dian Estu , Widyahening Indah Suci
Published: June 2019

Background

To document ocular abnormalities in healthy full-term newborn infants using wide-field digital imaging and to analyze factors associated with the findings.

Methods

A total of 1208 full-term newborn infants at a tertiary eye hospital (Cipto Mangunkusumo National Referral Hospital) and a district hospital in Jakarta (Koja Hospital) were enrolled to the study. All eligible newborns underwent fundus examination within 48 hours after birth using the RetCam shuttle (Natus Medical Incorporated, USA). All eye findings were documented and analyzed according to obstetric and neonatal risk factors.

Results

Of the 1208 newborn infants enrolled, ocular abnormalities were found in 150 infants (12.4%). Retinal hemorrhage (RH) was the most common findings (88%) in which 2.67% involved the macula, followed with chorioretinitis (4.67%). Univariate analysis showed caesarean section (C-section) (OR 0.27, 95% CI 0.18-0.41, p<0.001) as the protective factor towards RH, while prolonged labor increased the risk of developing RH (OR 1.84, 95% CI 1.24-2.72, p=0.002). Further multivariate analysis showed similar protective association between C-section and risk of RH (OR 0.29, 95% CI 0.19-0.44, p<0.001), while other risk factors were not.

Conclusions

Our study supports previous reports that universal eye screening is an essential procedure which may detect several important ocular abnormalities. Retinal hemorrhage is the most common ocular abnormality and is associated with the methods of delivery and duration of labor. As the ocular abnormalities may go unnoticed during standard practice, a universal eye screening program could be considered as an essential part of newborn screening especially amongst those with prolonged labors.
Risk factors of cartilage regeneration in patients who underwent high tibial osteotomy combined with microfracture
Authors: Seon Jong Keun , Ingle Pramod Shaligram , Song Eun-Kyoo , Cho Kyu-Jin , Na Seung-Min , Ko Jee-Wook
Published: June 2019

Background: One of the option for treating unicompartmental osteoarthritis (OA) is high tibial osteotomy (HTO). HTO which can shift the mechanical axis to the lateral compartment, can performed with microfracture which provides cells capable of producing cartilage. And this procedure is one of the common combinations that orthopaedic surgeons are in practice recently. The purpose of this study was to evaluate the degree of regeneration of cartilage after performing microfracture (MF) with high tibial osteotomy (HTO) after 2- year follow up and identify the factors influencing the regeneration of cartilage after the procedure. We also evaluated whether the regenerated cartilage status affects clinical outcomes.
Methods: A total of 81 cases that underwent second-look arthroscopy at the time of plate removal after MF and HTO with a minimum two-year follow-up were included. The patients were divided into two groups according to femoral cartilage regeneration. Multivariable logistic regression analyses were performend to identify independent factors that influence cartilage regeneration. We also compared differences in functional outcomes between the two groups.
Results: On the femoral side, grade I cartilage regeneration was found in seven (8.6%), grade II in 19 (23.5%), grade III in 26 (32.1%), and grade IV in 29 cases (35.8%), resulting in 26 (32.1%) patients belonging to well regenerated group (group A) and 55 (67.9%) to the poorly regenerated group (group B). Among factors, the size of the cartilage lesion (P=.011) and the presence of kissing lesions (P=.027) significantly affected cartilage regeneration. There were no statistically significant differences between group A and group B in terms of KSS and WOMAC scores.
Conclusions: A large cartilage defect and the presence of kissing lesions are associated with poor cartilage regeneration after combined MF and HTO surgery. However, the quality of regenerated cartilage does not affect functional outcomes in patients with MF and HTO.

Keywords: High tibial osteotomy, Microfracture, Second-look arthroscopy, Cartilage regeneration, risk factor
Challenges with Scale-up of GeneXpert MTB/RIF® in Uganda: a Health Systems Perspective
Authors: Nalugwa Talemwa , Shete Priya B. , Nantale Mariam , Farr Katherine , Ojok Christopher , Ochom Emma , Mugabe Frank , Joloba Moses , Dowdy David W. , Moore David A.J. , Davis J. Lucian , Cattamanchi Adithya , Katamba Achilles
Published: June 2019

Background

Many high burden countries are scaling-up GeneXpert® MTB/RIF (Xpert) testing for tuberculosis (TB) using a hub-and-spoke model. However, the effect of scale up on reducing TB has been limited. We sought to characterize variation in implementation of referral-based Xpert TB testing across Uganda, and to identify health system factors that may enhance or prevent high-quality implementation of Xpert testing services.

Methods

We conducted a cross-sectional study triangulating quantitative and qualitative data sources at 23 community health centers linked to one of 15 Xpert testing sites between November 2016 and May 2017 to assess health systems infrastructure for hub-and-spoke Xpert testing. Data sources included a standardized site assessment survey, routine TB notification data, and field notes from site visits.

Results

Challenges with Xpert implementation occurred at every step of the diagnostic evaluation process, leading to low overall uptake of testing. Of 2,241 patients eligible for TB testing, only 580 (26%) were referred for Xpert testing. Of those, 57 (9.6%) were Xpert confirmed positive just over half initiated treatment within 14 days (n=33, 58%). Gaps in required infrastructure at 23 community health centers to support the hub-and-spoke system included lack of refrigeration (n=14, X%) for sputum testing and lack of telephone/mobile communication (n=21, 91%). Motorcycle riders responsible for transporting sputum to Xpert sites operated variable with trips once a week, 2x/week or 3x/week at 10 (43%), 9 (39%) and 4 (17%) health centers, respectively. Staff recorded Xpert results in the TB laboratory register at only one health center and called patients with positive results at only 2 health centers. Of the 15 Xpert testing sites, 5 (33%) had at least one non-functioning module. The median number of tests per day was 3.57 (IQR 2.06-4.54), and 10 (67%) sites had error/invalid rates >5%.

Conclusions

Although Xpert devices are now widely distributed throughout Uganda, health system factors across the continuum from test referral to results reporting and treatment initiation preclude effective implementation of Xpert testing for patients presenting to peripheral health centers. Support for scale up of innovative technologies should include support for communication, coordination and health systems integration.
Prediction of hemodynamic reactivity by electroencephalographically derived Pain Rating Index in children during general anesthesia: a prospective observational study
Authors: Wu Lei , Wang Siyuan , Wang Yanting , Zhang Kan , Bai Jie , Zhang Mazhong , Zheng Jijian
Published: June 2019

Background: Pain rating index (PRI) is a novel measure of nociception based on integrated electroencephalogram parameters during general anesthesia. Wavelet index (WLI) as a sedation index reflects the patient's sedation state. This study aims to evaluate the performance of PRI and WLI to predict hemodynamic reactivity after tracheal intubation and skin incision in pediatric patients.
Methods: 134 children undergoing elective general or urinary surgery were analyzed. PRI, WLI, heart rate (HR), and mean blood pressure (MBP) were measured at predefined time-points during tracheal intubation and skin incision. Receiver-operating characteristic (ROC) curves were computed to evaluate the predictive performance of PRI and WLI to measure hemodynamic reactivity (increase by more than 20% of either MBP or HR) during general anesthesia.
Results: In 134 patients, positive reactivity of HR and MBP was observed in 95 (70.9%) and 61 (45.5%) patients induced by endotracheal intubation and 19 (14.2%) and 24 (17.9%) patients induced by skin incision. Using either HR or MBP reactivity induced by tracheal intubation as a dichotomous variable, the areas under the curves (AUCs) [95% CI] of PRI and WLI were 0.81[0.73-0.87] and 0.58[0.49-0.67] with the best cutoff values of 62 and 49; The AUCs [95% CI] of PRI and WLI were 0.82[0.75-0.88] and 0.61[0.52-0.69] after skin incision, the best cutoff values of PRI and WLI were 60 and 46, respectively.
Conclusions: PRI can predict hemodynamic reactivity with the best cutoff values of 62 and 60 after tracheal intubation and skin incision in pediatric patients during general anesthesia while WLI failed in predicting hemodynamic changes.
Trial registration: Chinese Clinical Trial Register (Unique identifier: ChiCTR1800015969, Date of registration: May 3, 2018).
Key words: Pain Rating Index, Wavelet index, Hemodynamic reactivity, Pediatric patients
A comparison between the Disposcope endoscope and fiberoptic bronchoscope for nasotracheal intubation-A randomized controlled trial
Authors: Yu Junma , Hu Rui , Wu Lining , Sun Peng , Zhang Zhi
Published: June 2019

Background

Nasotracheal intubation (NTI) is frequently performed in oral and maxillofacial surgeries. This study evaluated whether NTI is easier when guided by Disposcope endoscopy or fiberoptic bronchoscopy.

Methods

Sixty patients (30 per group) requiring NTI were randomly assigned to undergo fiberoptic bronchoscopy-guided (fibreoptic group) or Disposcope endoscope-guided (Disposcope group) NTI. Then, the NTI time were recorded. Epistaxis was recorded using direct laryngoscopy ﬁve minutes after completing NTI.

Results

The time to complete NTI was significantly longer in the fiberoptic group than the Disposcope group (38.4 sec vs 24.1 sec; mean difference, 14.2 sec; 95% CI, 10.4 to 18.1). In addition, Mild epistaxis (nasal bleeding) was observed in 8 patients in the fiberoptic group and 7 patients in the Disposcope group (26.7% vs 23.3%, respectively; relative risk, 1.2; 95% CI, 0.4 to 3.9). No moderate or severe epistaxis occurred in either group. Furthermore, there was no obvious nasal pain at any time point after extubation in the Disposcope group, and there was no significant difference between the two groups.

Conclusion

NTI can be completed successfully using either fiberoptic bronchoscopy or a Disposcope endoscope as a guide without any severe adverse reactions. However, compared to fiberoptic bronchoscopy, the Disposcope endoscope requires less transaction time.
Relación entre la exposición a la violencia de pareja y los malos tratos en el noviazgo
Authors: Bonilla-Algovia Enrique , Rivas-Rivero Esther
Published: June 2019

El objetivo de la investigación es analizar la relación entre la exposición a la violencia de pareja y la victimización y perpetración de malos tratos en el noviazgo. La información se obtuvo mediante un cuestionario autoaplicado y la metodología fue de corte transversal. La muestra está compuesta por 443 estudiantes (317 mujeres y 126 hombres) de diferentes universidades colombianas. Los resultados muestran que el 60% fue testigo de agresiones físicas y psicológicas entre alguna pareja del entorno; la mayoría de estas se ejercieron contra mujeres. La exposición a la violencia está relacionada tanto con la perpetración como con la victimización de maltrato en el noviazgo. En consecuencia, la identificación de los factores de riesgo de este tipo de violencia permite realizar programas de intervención específicos, prevenir su aparición y reducir su prevalencia.
Aplicación de normas de inocuidad y calidad en el Asparagus Officinalis peruano
Authors: Vilca Miriam
Published: June 2019

El objetivo del presente artículo es insertar los conocimientos básicos para los estudiantes de Ingeniería Agroindustrial, Ingenieros de Alimentos, Ingenieros Químicos y carreras afines, también al público interesado en conocer más sobre el Espárrago de nuestro País. Las Empresas no establecen un estándar en la determinación de las normas de inocuidad y calidad en los espárragos, motivo por el cual se pretende plantear el ciclo de Deming (Planear, hacer, verificar, y actuar) y con el Kaizen aportar a la mejora continua. El Perú podría recuperar siendo el primer productor a nivel mundial y ganarle a México, puesto que hay factores climáticos del niño costero que hacen dificultoso sea relevante. El precio según AGRODATA menciona que en el 2018 estaba en 18% y este año 2019 alcanzo en el mes de Enero apenas el 8%.Palabras clave: Normas, espárrago, calidad, inocuida
Gnoseología del docente universitario como elemento social Posgrado de la Universidad Alas Peruanas
Authors: Ramirez Julca Máximo , Estrada Mauro , Ramírez Rodolfo
Published: June 2019

La investigación realizada tuvo como objetivos: describir y explicar la relación que existe entre gnoseología del docente universitario como elemento social en la Escuela de Posgrado de la Universidad Alas Peruanas, para estar a la par con el cambio acelerado de la ciencia y la tecnología en el proceso de enseñanza y aprendizaje, en la formación del docente universitario. El método de muestreo utilizado fue el aleatorio simple empleando una muestra por conglomerados. El instrumento aplicado fue la encuesta que tuvo por finalidad conocer la opinión de los docentes universitarios, acerca de la relación existente entre la gnoseología como elemento social a nivel de la docencia universitaria. En actuales circunstancias, la ciencia y la tecnología suministra herramientas necesarias para hacer realidad el estudio de la gnoseología, social empero, no se trata de convertir al docente universitario en un pedagogo o un tecnólogo profesional, ello solo haría descuidar su disciplina profesional y científica, sino que aporta a la formación social del profesional, con nuevas posibilidades en los procesos de enseñanza y aprendizaje, mediante la virtualización de la información.
The Effect of Flaxseed Flour on the Rheological Properties of Dough Made of Flaxseed and Wheat Flour and Bread Quality
Authors: Конева Светлана , Koneva Svetlana , Егорова Елена , Egorova Elena , Козубаева Людмила , Kozubaeva Lyudmila , Резниченко Ирина , Reznichenko Irina
Published: June 2019

Flax seeds are a valuable source of several active components and can be used for controlled modeling of bakery food value. The study featured flour mixes of first grade wheat flour and flaxseed flour (flax meal) in the ratio 92.5%:7.5%; 90.0%:10.0%, and 87.5%:12.5%. The rheological properties of the dough were studied using the Mixolab (Chopin Technologies, France). The laboratory was located at the Polzunov Altai State Technical University (Barnaul, Russia). The mixolabogram and radial diagram were used to define the differences in the parameters of the rheological profile of the 4 flour samples. With the increase of flaxseed flour in the composition, the mixing time increased from 5.58 to 5.77 minutes, and the stable state of the dough became longer: from 9.25 to 9.67 minutes. The water ab-sorption capacity of flour mixes directly depended on the dosage of flax flour and increased from 69.4 to 72.9%. However, viscosity, amylolytic activity, and retrogradation revealed inversed dependence on the dosage of flax flour. The moisture content of the dough increased from 47.0 to 50.0% and the initial acidity of the dough increased from 2.5 to 3.5 degree with the increasing dosage of flax flour, which changed the dynamics of acidification during fermentation. This resulted in a more rapid maturation of dough and reduced the total fermentation period from 90 to 60 minutes. Thus, the flax flour mixes can be characterized as “fillers” that produce bread of reduced volume. The authors state the optimal dosage of flax flour as 7.5–10.0% and propose various modes of the technological process for obtaining bread with good consumer properties.
Assessing vertical and horizontal movements of algal blooms in a coastal water using satellite remote sensing for optimal operation of desalination plants
Authors: Chen H. , Park M.-H.
Published: June 2019

Harmful algal blooms (HABs) are global concerns in coastal waters due to diffuse pollution and climate change. Emerging issues of HABs include their impact on desalination operations for water supply. This study utilizes composite satellite images to detect movement and propagation of algal blooms. Time series images from the Moderate-Resolution Imaging Spectroradiometer (MODIS) were used for monitoring chlorophyll-a in the Persian (Arabian) Gulf, which neighboring countries depend upon for desalination as their freshwater resource. Bi-daily MODIS data from the Terra and Aqua satellites were used to detect both vertical migration and horizontal movement of algal blooms. The results will be useful for creating an early warning system for desalination plants to anticipate operating strategies and intake locations to minimize impacts.
Degradation of α-terpineol in aqueous solution by UV/H2O2: kinetics, transformation products and pathways
Authors: Yao Jie , Guo Jinglin , Yang Zhaoguang , Li Haipu , Qiu Bo
Published: June 2019

The monoterpene alcohol α-terpineol is extensively used as the foaming agent in mineral processing and can be released to environment along with the wastewater. This study evaluated the feasibility of eliminating α-terpineol in water by ultraviolet irradiation (UV) in combination with hydrogen peroxide (H2O2). Within an H2O2 dose of 10 mg/L and an UV fluence of 64.8 J/cm2, more than 95% of the α-terpineol can be removed. The reactions fitted well to pseudo-first-order kinetics, and the apparent rate constant was 0.0678 min−1. The effects of matrix species including various anions and humic acid (HA), were evaluated. The degradation rate decreased significantly with the addition of bicarbonate and HA. Further verification was carried out with three types of real water samples. In the ground water and the surface water, the degradation rate decreased likely due to the presence of natural organic matter. Finally, possible degradation pathways were proposed based on the identification of transformation products, and the occurrence of two main transformation products were monitored. This study demonstrated that the UV/H2O2 is an effective technology for the degradation of α-terpineol in water.
Recent Advances in Spontaneous Raman Spectroscopic Imaging: Instrumentation and Applications
Authors: Wang Nan , Cao Honghao , Wang Lin , Ren Feng , Zeng Qi , Xu Xinyi , Liang Jimin , Zhan Yonghua , Chen Xueli
Published: June 2019

Background:

Spectroscopic imaging based on the spontaneous Raman scattering effects
can provide unique fingerprint information in relation to the vibration bands of molecules. Due to its
advantages of high chemical specificity, non-invasive detection capability, low sensitivity to water,
and no special sample pretreatment, Raman Spectroscopic Imaging (RSI) has become an invaluable
tool in the field of biomedicine and medicinal chemistry.

Methods:

There are three methods to implement RSI, including point scanning, line scanning and
wide-field RSI. Point-scanning can achieve two-and three-dimensional imaging of target samples.
High spectral resolution, full spectral range and confocal features render this technique highly attractive.
However, point scanning based RSI is a time-consuming process that can take several hours
to map a small area. Line scanning RSI is an extension of point scanning method, with an imaging
speed being 300-600 times faster. In the wide-field RSI, the laser illuminates the entire region of
interest directly and all the images then collected for analysis. In general, it enables more accurate
chemical imaging at faster speeds.

Results:

This review focuses on the recent advances in RSI, with particular emphasis on the latest
developments on instrumentation and the related applications in biomedicine and medicinal chemistry.
Finally, we prospect the development trend of RSI as well as its potential to translation from
bench to bedside.

Conclusion:

RSI is a powerful technique that provides unique chemical information, with a great
potential in the fields of biomedicine and medicinal chemistry.
Factors Affecting the Metabolite Productions in Endophytes: Biotechnological Approaches for Production of Metabolites
Authors: Morales-Sánchez Viridiana , Fe Andrés Maria , Díaz Carmen Elisa , González-Coloma Azucena
Published: June 2019

:

Since 1980, many species and different strains from endophytic genera of Phomopsis, Fusarium, Pestaliopsis and Aspergillus have been studied because of their ability to produce medicinal compounds found in their host plants. Some of these medicinal agents such as Taxol, Brefeldine A, Camptothecin and Podophyllotoxin are being produced in large-scale after an optimization process. However, the potential of fungal endophytes to produce host-like medicinal compounds remains largely unexplored.
Personalized Peptide-based Vaccination for Treatment of Colorectal Cancer: Rational and Progress
Authors: Parizadeh Seyed Mostafa , Jafarzadeh-Esfehani Reza , Ghandehari Maryam , Rezaei-Kalat Afsaneh , Parizadeh Seyed Mohammad Reza , Javanbakht Afsane , Hassanian Seyed Mahdi , Ferns Gordon A. , Khazaei Majid , Avan Amir
Published: June 2019

Colorectal cancer (CRC) is one of the most common cancers globally and is associated with
a high rate of morbidity and mortality. A large proportion of patients with early stage CRC, who undergo
conventional treatments develop local recurrence or distant metastasis and in this group of advanced
disease, the survival rate is low. Furthermore there is often a poor response and/or toxicity associated
with chemotherapy and chemo-resistance may limit continuing conventional treatment alone.
Choosing novel and targeted therapeutic approaches based on clinicopathological and molecular features
of tumors in combination with conventional therapeutic approach could be used to eradicate residual
micrometastasis and therefore improve patient prognosis and also be used preventively. Peptide-
based vaccination therapy is one class of cancer treatment that could be used to induce tumorspecific
immune responses, through the recognition of specific antigen-derived peptides in tumor
cells, and this has emerged as a promising anti-cancer therapeutic strategy. The aim of this review was
to summarize the main findings of recent studies in exciting field of peptide-based vaccination therapy
in CRC patients as a novel therapeutic approach in the treatment of CRC.
Three Cases of Leber’s Hereditary Optic Neuropathy with Rapid Increase in Visual Acuity After Gene Therapy
Authors: Zhang Yong , Yuan Jia-jia , Liu Hong-li , Tian Zhen , Liu Si-wei , Li Bin
Published: June 2019

Background:

During the first few trials of gene therapy for Leber’s hereditary optic
neuropathy performed by our group, the visual acuity of the patients increased gradually over several
months, or even years. However, in the current round of gene therapy for Leber’s hereditary optic neuropathy,
we noted that the visual acuity of three patients increased rapidly, within a few days after
treatment.

Case presentation:

Three patients who were diagnosed with mitochondrial gene 11778 mutation (associated
with a G-to-A transition at Mt-11778 in the ND4 subunit gene of complex I of mitochondrial
DNA that changes an arginine to histidine at amino acid 340) by genetic diagnosis were followed up
three times before gene therapy, which lasted for 1 year, without spontaneous improvement of vision.
Visual acuity in one or both eyes of each of the three patients increased rapidly after the initial gene
therapy treatment.

Conclusions:

We suspect that in some patients with Leber’s hereditary optic neuropathy, a portion of
the retinal ganglion cells might remain in a “dormant” state for a certain period of time; these may be
activated, within an optimal timeframe, during gene therapy for Leber’s hereditary optic neuropathy.
Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases
Authors: Ivasiv Viktoriya , Albertini Claudia , Gonçalves Ana E. , Rossi Michele , Bolognesi Maria L.
Published: June 2019

Molecular hybridization is a well-exploited medicinal chemistry strategy that aims to combine
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been recognized
as an effective approach to design ligands able to modulate multiple targets of interest. Hybrid compounds
can be obtained by linking (presence of a linker) or framework integration (merging or fusing)
strategies. Although very promising to combat the multifactorial nature of complex diseases, the development
of molecular hybrids faces the critical issues of selecting the right target combination and the
achievement of a balanced activity towards them, while maintaining drug-like-properties. In this review,
we present recent case histories from our own research group that demonstrate why and how molecular
hybridization can be carried out to address the challenges of multitarget drug discovery in two therapeutic
areas that are Alzheimer’s and parasitic diseases. Selected examples spanning from linker- to fragment-
based hybrids will allow to discuss issues and consequences relevant to drug design.
How to Treat Osteoarthritis in Obese Patients?
Authors: Conrozier Thierry
Published: June 2019

:

The close association between osteoarthritis (OA) and obesity is well established.
Mechanisms linking obesity and OA involve multifactorial phenomena such as systemic factors
(i.e. adipokines and pro-inflammatory cytokines), hormonal disturbances (hyperinsulinemia) and
muscule changes (i.e. sarcopenia and lower muscular tone). The concomitant increasing prevalence
of the two diseases have major health, social and economic consequences. However, to date no
specific recommendation for the medical management of obese patients with OA have been published.
Current recommendations only specify that obese patients must lose weight and practice
regular physical activity in addition to the usual care. Weight loss improves not only OA symptoms
but also metabolic abnormalities and cardiovascular risk factors commonly altered in subjects with
obesity. OA symptoms’ improvement has been shown to become clinically relevant from a weight
loss > 5% of the body weight. In case of morbid obesity, bariatric surgery may be the only alternative
for pain relief. After bariatric surgery, an appropriate calcium and vitamin D intake is recommended,
since it has been shown that bariatric surgery was associated with a reduction in the bone
mineral density and increased risk of fractures. An exercise program is essential for preserving
healthy muscles during weight loss.

:

Non-steroidal anti-inflammatory drugs and corticosteroids must be avoided, especially in obese patients
with metabolic syndrome. In such patients symptomatic slow acting drugs for OA (i.e. glucosamine,
chondroitin) and some anti-oxidant drugs (i.e. curcumin, ginger extracts, copper) may be
helpful thanks to their excellent benefit/risk ratio and their mode of action which may have a positive
impact on both OA and obesity-related metabolic disorders. Recent research focuses on the development
of molecules aimed for promoting the production of heme oxygenase (HO-1). HO-1 decreases
the production of oxygen free radicals and protects tissues from oxidative stress in the insulin
resistance syndrome. Intra-articular (IA) injections of hyaluronic acid and corticosteroid have
few adverse events. However, physicians must inform patients that IA treatments have a lower success
rate in obese patients than in those with normal body mass index. Spa therapy contributes to
relief pain, favour weight-loss and reduces metabolic abnormalities with a favourable risk/benefit
balance.
Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?
Authors: Salazar Juan , Rojas-Quintero Joselyn , Cano Clímaco , Pérez José L. , Ramírez Paola , Carrasquero Rubén , Torres Wheeler , Espinoza Cristobal , Chacín-González Maricarmen , Bermúdez Valmore
Published: June 2019

Arterial hypertension is the most prevalent chronic disease in the adult population of developed
countries and it constitutes a significant risk factor in the development of cardiovascular
disease, contributing to the emergence of many comorbidities, among which heart failure excels, a
clinical syndrome that nowadays represents a major health problem with uncountable hospitalizations
and the indolent course of which progressively worsens until quality of life decreases and
lastly death occurs prematurely. In the light of this growing menace, each day more efforts are invested
in the field of cardiovascular pharmacology, searching for new therapeutic options that allow
us to modulate the physiological systems that appear among these pathologies. Therefore, in
the later years, the study of natriuretic peptides has become so relevant, which mediate beneficial
effects at the cardiovascular level such as diuresis, natriuresis, and decreasing cardiac remodeling;
their metabolism is mediated by neprilysin, a metalloproteinase, widely expressed in the human and
capable of catalyzing many substrates. The modulation of these functions has been studied by decades,
giving room to Sacubitril, the first neprilysin inhibitor, which in conjunction with an angiotensin
receptor blocker has provided a high efficacy and tolerability among patients with heart failure,
for whom it has already been approved and recommended. Nonetheless, in the matter of arterial
hypertension, significant findings have arisen that demonstrate the potential role that it will play
among the pharmacological alternatives in the upcoming years.
Therapeutic Value of Vitamin D as an Adjuvant Therapy in Neonates with Sepsis
Authors: Hagag Adel A. , El Frargy Mohamed S. , Houdeeb Hoassam A.
Published: June 2019

:

Sepsis is unusual systemic reaction to an ordinary infection, and it probably represents
a pattern of response by the immune system to the injury. Vitamin D is a fat-soluble steroid hormone
that contributes to the maintenance of normal calcium homeostasis and skeletal mineralization.
Vitamin D has an important role in the regulation of both innate and adaptive immune systems.

Aim of the Work:

The current study aimed to evaluate the therapeutic value of vitamin D supplementation
as an adjuvant therapy in neonates with sepsis.

Subjects and Method:

This study included 60 neonates with sepsis who were randomly divided
into 2 equal groups; group I: 30 neonates with sepsis who received antibiotic only, Group II: 30
neonates with sepsis who received antibiotic therapy and vitamin D. This study also included 30
healthy neonates as a control group. For all patients and controls, serum level of 25 (OH) vitamin
D and highly sensitive C reactive protein (hs-CRP) were immunoassayed.

Results:

There is no significant difference between groups I, II and controls regarding weight,
gestational age, sex and mode of delivery. There were significant differences between groups I
and II in sepsis score and hs-CRP after 3, 7, 10 days of treatment (p values for sepsis score were
0.009, 0.006, 0.004 respectively and for hs-CRP were 0.015, 0.001, 0.001 respectively). There
was a significant difference in immature /total (I/T) ratio after 7, and 10 days of treatment (p
value= 0.045, 0.025, respectively,) while there was no significant difference in immature /total
(I/T) ratio after 3 days of treatment (p value = 0.624).Serum 25(OH) vitamin D levels were significantly
lower in neonates with sepsis (group I and II) than the controls (p value < 0.05, while
there were no significant differences between the three groups considering serum calcium and
phosphorus levels (P =1.000, 1.000, respectively). Isolated organisms from blood culture in neonates
with sepsis (group I and group II) were most commonly B- hemolytic streptococci, E-coli,
hemophilus influenza and staphylococcus aurous. There was a significant negative correlation between
hs-CRP and serum 25 (OH) vitamin in group II on entry (r = - 0.832 and P value = 0.001)
and after 2 weeks (r = - 0.590 and P value = 0.021). ROC curve of specificity and sensitivity of 25
(OH) vitamin D level in prediction of early-onset neonatal sepsis showed that cutoff value of vitamin
D was ≤20 ng/ml, sensitivity was 100%, specificity was 73%, positive predictive value was
73%, negative predictive value was 100% and accuracy was 87.

Conclusion and Recommendation:

Serum 25 (OH) vitamin D levels of neonates with the early
onset neonatal sepsis were significantly lower than the healthy controls. Vitamin D supplementation
improved sepsis score and decrease high levels of hs-CRP; this reflects the role of vitamin D
as a target therapy for neonatal sepsis. Further studies are warranted to confirm the therapeutic
value of vitamin D in neonatal sepsis.