bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive factors of incomplete aneurysm occlusion after endovascular treatment with the Pipeline embolization device
Authors: Maragkos Georgios A. , Ascanio Luis C. , Salem Mohamed M. , Gopakumar Sricharan , Gomez-Paz Santiago , Enriquez-Marulanda Alejandro , Jain Abhi , Schirmer Clemens M. , Foreman Paul M. , Griessenauer Christoph J. , Kan Peter , Ogilvy Christopher S. , Thomas Ajith J.
Published: April 2019

OBJECTIVE

The Pipeline embolization device (PED) is a routine choice for the endovascular treatment of select intracranial aneurysms. Its success is based on the high rates of aneurysm occlusion, followed by near-zero recanalization probability once occlusion has occurred. Therefore, identification of patient factors predictive of incomplete occlusion on the last angiographic follow-up is critical to its success.

METHODS

A multicenter retrospective cohort analysis was conducted on consecutive patients treated with a PED for unruptured aneurysms in 3 academic institutions in the US. Patients with angiographic follow-up were selected to identify the factors associated with incomplete occlusion.

RESULTS

Among all 3 participating institutions a total of 523 PED placement procedures were identified. There were 284 procedures for 316 aneurysms, which had radiographic follow-up and were included in this analysis (median age 58 years; female-to-male ratio 4.2:1). Complete occlusion (100% occlusion) was noted in 76.6% of aneurysms, whereas incomplete occlusion (≤ 99% occlusion) at last follow-up was identified in 23.4%. After accounting for factor collinearity and confounding, multivariable analysis identified older age (> 70 years; OR 4.46, 95% CI 2.30–8.65, p < 0.001); higher maximal diameter (≥ 15 mm; OR 3.29, 95% CI 1.43–7.55, p = 0.005); and fusiform morphology (OR 2.89, 95% CI 1.06–7.85, p = 0.038) to be independently associated with higher rates of incomplete occlusion at last follow-up. Thromboembolic complications were noted in 1.4% and hemorrhagic complications were found in 0.7% of procedures.

CONCLUSIONS

Incomplete aneurysm occlusion following placement of a PED was independently associated with age > 70 years, aneurysm diameter ≥ 15 mm, and fusiform morphology. Such predictive factors can be used to guide individualized treatment selection and counseling in patients undergoing cerebrovascular neurosurgery.
Stasis index from hemodynamic analysis using quantitative DSA correlates with hemorrhage of supratentorial arteriovenous malformation: a cross-sectional study
Authors: Lin Te Ming , Yang Huai Che , Lee Cheng Chia , Wu Hsiu Mei , Hu Yong Sin , Luo Chao Bao , Guo Wan Yuo , Kao Yi Hsuan , Chung Wen Yuh , Lin Chung Jung
Published: April 2019

OBJECTIVE

Assessments of hemorrhage risk based on angioarchitecture have yielded inconsistent results, and quantitative hemodynamic studies have been limited to small numbers of patients. The authors examined whether cerebral hemodynamic analysis using quantitative digital subtraction angiography (QDSA) can outperform conventional DSA angioarchitecture analysis in evaluating the risk of hemorrhage associated with supratentorial arteriovenous malformations (AVMs).

METHODS

A cross-sectional study was performed by retrospectively reviewing adult supratentorial AVM patients who had undergone both DSA and MRI studies between 2011 and 2017. Angioarchitecture characteristics, DSA parameters, age, sex, and nidus volume were analyzed using univariate and multivariate logistic regression, and QDSA software analysis was performed on DSA images. Based on the QDSA analysis, a stasis index, defined as the inflow gradient divided by the absolute value of the outflow gradient, was determined. The receiver operating characteristic (ROC) curve was used to compare diagnostic performances of conventional DSA angioarchitecture analysis and analysis using hemodynamic parameters based on QDSA.

RESULTS

A total of 119 supratentorial AVM patients were included. After adjustment for age at diagnosis, sex, and nidus volume, the exclusive deep venous drainage (p < 0.01), observed through conventional angioarchitecture examination using DSA, and the stasis index of the most dominant drainage vein (p = 0.02), measured with QDSA hemodynamic analysis, were independent risk factors for hemorrhage. The areas under the ROC curves for the conventional DSA method (0.75) and QDSA hemodynamics analysis (0.73) were similar. A venous stasis index greater than 2.18 discriminated the hemorrhage group with a sensitivity of 52.6% and a specificity of 81.5%.

CONCLUSIONS

In QDSA, a higher stasis index of the most dominant drainage vein is an objective warning sign associated with supratentorial AVM rupture. Risk assessments of AVMs using QDSA and conventional DSA angioarchitecture were equivalent. Because QDSA is a complementary noninvasive approach without extra radiation or contrast media, comprehensive hemorrhagic risk assessment of cerebral AVMs should include both DSA angioarchitecture and QDSA analyses.
Comparative analysis of anterior cervical discectomy and fusion in the inpatient versus outpatient surgical setting
Authors: Patel Dil V. , Yoo Joon S. , Haws Brittany E. , Khechen Benjamin , Lamoutte Eric H. , Karmarkar Sailee S. , Singh Kern
Published: April 2019

OBJECTIVE

In a large, consecutive series of patients treated with anterior cervical discectomy and fusion (ACDF) performed by a single surgeon, the authors compared the clinical and surgical outcomes of patients who underwent ACDF in an inpatient versus outpatient setting.

METHODS

Patients undergoing primary ACDF were retrospectively reviewed and stratified by surgical setting: hospital or ambulatory surgical center (ASC). Data regarding perioperative characteristics, including hospital length of stay and complications, were collected. Neck Disability Index (NDI) and visual analog scale (VAS) scores were used to analyze neck and arm pain in the preoperative period and at 6 weeks, 3 months, 6 months, and 12 months postoperatively. Postoperative outcomes were compared using chi-square analysis and linear regression.

RESULTS

The study included 272 consecutive patients undergoing a primary ACDF, of whom 172 patients underwent surgery at a hospital and 100 patients underwent surgery at an ASC. Patients undergoing ACDF in the hospital setting were older, more likely to be diabetic, and had a higher comorbidity burden. Patients receiving treatment in the ASC were more likely to carry Workers’ Compensation insurance. Patients in the hospital cohort were more likely to have multilevel procedures, had greater blood loss, and experienced a longer length of stay. In the hospital cohort, 48.3% of patients were discharged within 24 hours, while 43.0% were discharged between 24 and 48 hours after admission. Both cohorts had similar VAS pain scores on postoperative day (POD) 0; however, the hospital cohort consumed more narcotics on POD 0. One patient in the ASC cohort had a pretracheal hematoma that was evacuated immediately in the same surgical center. There were 8 cases of dysphagia in the hospital cohort and 3 cases in the ASC cohort, all of which resolved before the 6-month follow-up. Both cohorts demonstrated similar NDI and VAS neck and arm pain scores preoperatively and at every postoperative time point.

CONCLUSIONS

Although patients undergoing ACDF in the hospital setting were older, had a greater comorbidity burden, and underwent surgery on more levels than patients undergoing ACDF at an outpatient center, this study demonstrated comparable surgical and clinical outcomes for both patient groups. Based on the results of this single surgeon’s experience, 1- to 2-level ACDFs may be performed successfully in the outpatient setting in appropriately selected patient populations.
Effect of decompressive craniectomy in the postoperative expansion of traumatic intracerebral hemorrhage: a propensity score–based analysis
Authors: Cepeda Santiago , Castaño-León Ana María , Munarriz Pablo M. , Paredes Igor , Panero Irene , Eiriz Carla , Gómez Pedro A. , Lagares Alfonso
Published: April 2019

OBJECTIVE

Traumatic intracerebral hemorrhage (TICH) represents approximately 13%–48% of the lesions after a traumatic brain injury (TBI), and hemorrhagic progression (HP) occurs in 38%–63% of cases. In previous studies, decompressive craniectomy (DC) has been characterized as a risk factor in the HP of TICH; however, few studies have focused exclusively on this relationship. The object of the present study was to analyze the relationship between DC and the growth of TICH and to reveal any correlation with the size of the craniectomy, degree of cerebral parenchymal herniation (CPH), or volumetric expansion of the TICH.

METHODS

The authors retrospectively analyzed the records of 497 adult patients who had been consecutively admitted after suffering a severe or moderate closed TBI. An inclusion criterion was presentation with one or more TICHs on the initial or control CT. Demographic, clinical, radiological, and treatment variables were assessed for associations.

RESULTS

Two hundred three patients presenting with 401 individual TICHs met the selection criteria. TICH growth was observed in 281 cases (70.1%). Eighty-two cases (20.4%) underwent craniectomy without TICH evacuation. In the craniectomy group, HP was observed in 71 cases (86.6%); in the noncraniectomy group (319 cases), HP occurred in 210 cases (65.8%). The difference in the incidence of HP between the two groups was statistically significant (OR 3.41, p < 0.01). The mean area of the craniectomy was 104.94 ± 27.5 cm2, and the mean CPH distance through the craniectomy was 17.85 ± 11.1 mm. The mean increase in the TICH volume was greater in the groups with a craniectomy area > 115 cm2 and CPH > 25 mm (16.12 and 14.47 cm3, respectively, p = 0.01 and 0.02). After calculating the propensity score (PS), the authors followed three statistical methods—matching, stratification, and inverse probability treatment weighting (IPTW)—thereby obtaining an adequate balance of the covariates. A statistically significant relationship was found between HP and craniectomy (OR 2.77, p = 0.004). This correlation was confirmed with the three methodologies based on the PS with odds greater than 2.

CONCLUSIONS

DC is a risk factor for the growth of TICH, and there is also an association between the size of the DC and the magnitude of the volume increase in the TICH.
High-resolution in vivo imaging of peripheral nerves using optical coherence tomography: a feasibility study
Authors: Carolus Anne E. , Lenz Marcel , Hofmann Martin , Welp Hubert , Schmieder Kirsten , Brenke Christopher
Published: April 2019

OBJECTIVE

Because of their complex topography, long courses, and small diameters, peripheral nerves are challenging structures for radiological diagnostics. However, imaging techniques in the area of peripheral nerve diseases have undergone unexpected development in recent decades. They include MRI and high-resolution sonography (HRS). Yet none of those imaging techniques reaches a resolution comparable to that of histological sections. Fascicles are the smallest discernable structure. Optical coherence tomography (OCT) is the first imaging technique that is able to depict a nerve’s ultrastructure at micrometer resolution. In the current study, the authors present an in vivo assessment of human peripheral nerves using OCT.

METHODS

OCT measurement was performed in 34 patients with different peripheral nerve pathologies, i.e., nerve compression syndromes. The nerves were examined during surgery after their exposure. Only the sural nerve was twice examined ex vivo. The Thorlabs OCT systems Callisto and Ganymede were used. For intraoperative use, a hand probe was covered with a sterile foil. Different postprocessing imaging techniques were applied and evaluated. In order to highlight certain structures, five texture parameters based on gray-level co-occurrence matrices were calculated according to Haralick.

RESULTS

The intraoperative use of OCT is easy and intuitive. Image artifacts are mainly caused by motion and the sterile foil. If the artifacts are kept at a low level, the hyporeflecting bundles of nerve fascicles and their inner parts can be displayed. In the Haralick evaluation, the second angular moment is most suitable to depict the connective tissue.

CONCLUSIONS

OCT is a new imaging technique that has shown promise in peripheral nerve surgery for particular questions. Its resolution exceeds that provided by recent radiological possibilities such as MRI and HRS. Since its field of view is relatively small, faster acquisition times would be highly desirable and have already been demonstrated by other groups. Currently, the method resembles an optical biopsy and can be a supplement to intraoperative sonography, giving high-resolution insight into a suspect area that has been located by sonography in advance.
FOSTERING CLINICAL THINKING IN DENTAL DOCTORS THROUGH POST-GRADUATION PROFESSIONAL TRAINING
Authors: Padalka A. I. , Kostenko V. G. , Sheshukova O. V.
Published: April 2019

During the internship training, future dental doctors expand knowledge about understanding the pathogenetic mechanisms of various pathological conditions or illnesses. Most contemporary effective diagnosis and treatment approaches are based on clinical thinking skills, the link between sciences and practice. The purpose of this study is to investigate and analyze the peculiarities of building up clinical thinking skills in future paediatric dentists at the postgraduate stage of their training. Developing clinical thinking skills in dental students typically starts since their junior years at the medical university, when they begin studying basic sciences. The background obtained during undergraduate training should be enriched in order to improve recognizing a wide variety of diseases and conditions through the internship training course. Professional thinking skills are fostered at the chair-side practice, when dealing with patients under the guidance of experienced mentors and clinicians. Clinical thinking switches on since the first minutes of doctor-patient interaction and goes on through the treatment course. At the postgraduate stage, it is essential to continue developing the holistic vision of the patient that will help to combine the evidence-based standards of medical care and patient-centred approach (personalized medical care). Conclusion. Thus, the training activities for dental intern doctors should be designed in order to maximally contribute to fostering clinical thinking skills. The mentors and teaching assistants must have clear and deep understanding of what factors can promote this process, and what can not. Among the most significant methodological achievements of postgraduate education is the emphasis on the development of critical and creative thinking skills, which are most clearly manifested by the creativity of clinical thinking.
METABOLISM OF HOMOCYSTEIN AND GLUTATHIONE IN ERYTHROCYTES IN HYPOTHERMAL STORAGE
Authors: Ramazanov V.V. , Volovelskaya E.L. , Rudenko S.V. , Semenchenko A.Yu. , Bondarenko V.A.
Published: April 2019

When hypothermic storage of red blood cellsб there is a decrease in the level of glutathione and an increase in the concentration of homocysteine, at the same time, inclusion in the medium of substrate amino-acids of the synthesis of glutathione activates the utilization of this cytotoxin. Moreover, stimulation of the synthesis of glutathione reduces the loss of membrane proteins and lowers the intensity of hemoglobin oxidation that ensures the preservation of the osmotic stability of erythrocytes. Red blood cells as a component of the body redox homeostasis absorb and neutralize reactive oxygen and nitrogen species, which normally determine a certain antioxidant potential and are not enough to maintain the structural and functional state of red blood cells after isolation from donor blood and storage. Oxidative stress in cells, including red blood cells, in various pathologies usually causes a decrease in the level of glutathione and an impairment of its synthesis that leads to an increase in the production of homocysteine ​​and its entry into the blood plasma. Homocysteine ​​is a cytotoxic amino acid that enhances the production of superoxide, limits the bioavailability of nitric oxide and causes the development of vascular pathology. The data presented in the review indicate that stimulation of the antioxidant potential of erythrocytes during the storage may prevent the development of oxidative stress and inflammation during subsequent transfusion. In addition, the preservation of the viability indicators of various cells during cryopreservation in a medium with substrate amino-acids shows that stimulation of the antioxidant potential contributes to an increase in the cell resistance to the damaging factors of freeze-thawing.
ANALGESIA FOR AGED AND GERIATRIC PATIENTS DURING CARDIAC SURGERY WITH CARDIOPULMONARY BYPASS
Authors: Druzhyna О.М. , Loskutov О.А. , Maruniak S.R.
Published: April 2019

Balanced perioperative multimodal analgesia using multiple synergistic agents minimizes side effects that can be caused by high doses of only one aesthetic agent. The aim of the work was to determine the efficacy of perioperative multimodal low-opioid analgesia as anesthetic assurance techniques in aged and geriatric patients during cardiac surgery with cardiopulmonary bypass.Materials and methods. The study included 18 patients (11 (61.1%) men and 7 (38.9%) women) aged from 63 to 76 years old (mean age 69.5±6.2 years), who underwent coronary artery bypass grafting with cardiopulmonary bypass support. The average body weight was 89.6±13.9 kg (75 to 115 kg). The anaesthesia consisted of intravenous (iv) administration of propofol in a dose of 1.52±0.05 mg/kg and fentanyl in a dose of 1 μg/kg. Muscle relaxation was achieved by injecting pipecuronium bromide in a dose of 0.1 mg/kg. Sevoflurane inhalation was used to maintain anesthesia. Before making incision, the subnarcotic dose of ketamine (0.5 mg / kg) and lidocaine 1 mg/kg bolus were added with simultaneous administration of the continuous infusion of the latter in a dose of 1.5-2 mg/kg per hour. For postoperative analgesia ketorolac tromethamine was used. The intensity of the pain syndrome was assessed using a 10-point visual-analog scale of pain. The level of endocrine-metabolic response was determined by measuring the dynamics of lactate and cortisol.Results. The average dose of fentanyl, which was used for the patient during the whole time of anaesthesia, was 1.09±0.03 μg / kg per hour (on average 358.3±27.1 μg for all time of surgery). During the extracorporeal circulation and in the early postoperative period, the blood circulation parameters in all patients examined corresponded to the hemodynamic profile of the operated pathology. Positive verbal contact with patients was recorded in 18.6±3.4 minutes after the end of anaesthesia. The level of cortisol in the early postoperative period was 479.3±26.4 nmol/l. The average values of the intraoperative level of lactate were 1.61±0.2 mmol/l. The mean pain level in the first postoperative day in the examined patients was 4.6 ± 1.2 (3-6) scores by VAS, one day after the operation – 2.6±1.1 (1.5-4) scores by the VAS.Conclusions. Multimodal low-opioid analgesia provides an adequate analgesic effect in aged and geriatric patients that is confirmed by the absence of hemodynamic and endocrine-metabolic disorders. The use of ketorolac as a component of multimodal low-opioid analgesia is an effective method for achieving adequate postoperative analgesia and contributes to reducing the side effects associated with the use of narcotic analgesics.
NEUROPHYSIOLOGICAL FEATURES OF THE NOCICEPTIVE TRIGEMINAL PATHWAY DURING DIFFERENT PHASES OF EPISODIC MIGRAINE
Authors: Nikiforova O. , Delva M.
Published: April 2019

Migraine is one of the most common primary headaches, caused by functional abnormalities of information processing, which can be investigated by neurophysiological means during the various phases of the migraine cycle. The aim of the work was to study neurophysiological changes by means of nociception-specific blink reflex characteristics of trigeminocervical complex and to compare neuro-physiological data with clinical manifestations during various phases of episodic migraine. Methods. A 24-year old female patient with episodic migraine without aura underwent daily nociceptive stimulation of the trigeminal nerve for 30 days. Clinical data were collected directly from the patient using structured questionnaires. Neurophysiological changes were assessed using electromyography study of trigeminocervical blink reflex that was caused by stimulation of the supraorbital nerve with high current density electrode. Results. Within one month, the patient had two migraine attacks, preceded by the prodromal phase, and at the end of both migraine attacks, postdrome symptoms were present. We observed cyclical changes in the characteristics of component R2 of the nociception-specific blink reflex that coincided with clinical manifestations in different phases of the migraine cycle. Conclusions. 1. Electrophysiological excitability of trigeminocervical complex nociceptors differs significantly during different phases of the migraine cycle. 2. The habituation of component R2 is observed in the period between attacks can be considered as a specific phenomenon that probably is the background for migraine attack occurrence. 3. The highest excitability and facilitation of the trigeminocervical complex (increased amplitude and decreased latency of component R2) were observed during ictal phase that is additional evidence of the key role of the brainstem in migraine pathophysiology.
THE INFLUENCE OF BACTERIAL OVERGROWTH SYNDROME ON THE EFFECTIVENESS OF ANTI-HELICOBACTER THERAPY IN PATIENTS WITH CHRONIC GASTRITIS AND TYPE 2 DIABETES MELLITUS
Authors: Radionova T.O.
Published: April 2019

Diabetic neuropathy often results in dysmotility of the gastrointestinal tract that induces further changes in its microbiotic spectrum. This can influence the course of concomitant diseases not related to diabetes mellitus and determine the effectiveness of their treatment. Aim: to investigate the effectiveness of anti-Helicobacter therapy in patients with chronic gastritis and concomitant type 2 diabetes, considering small intestinal bacterial overgrowth syndrome. Materials and methods: 64 patients with chronic Helicobacter pylori-positive gastritis were examined, 34 out of them had type 2 diabetes mellitus. Pantoprazole 40 mg, clarithromycin 500 mg, amoxicillin 1000 mg bid were prescribed to all the patients for 10 days. Before the treatment, on the 14th and 28th days of the therapy, a hydrogen breath test with lactulose to reveal small intestinal bacterial overgrowth, gastrointestinal symptoms monitoring, and re-determining Helicobacter pylori focal antigen on 28th day were performed. Results: on the 14th day of the treatment a decrease in the pain syndrome (n=28, 93% vs. n=10, 33%; p> 0.05), postprandial fullness (n=14, 47% vs. n = 4, 13% p>0.05) and nausea (n=13, 43% vs. n=4, 13% p>0.05) was observed among the non-diabetic patients with chronic gastritis. No statistical significance regarding abdominal pain regressing in patients with type 2 diabetes mellitus was found (n=16, 47% vs. n=9, 26%), postprandial fullness did not change noticeably (n=27, 79% vs. n=26, 76%), while the frequency of nausea increased (n=14, 41% vs. n=18, 53%). The incidence of small intestinal bacterial overgrowth significantly increased compared with the data before the therapy (n=16, 47% vs. n=27, 79%; p>0.05) and with non-diabetic patients (n = 15, 50% vs. n = 27,79%; p> 0.05). The effectiveness of H. pylori therapy was higher among patients without diabetes mellitus (77% vs. 65%). Conclusions: it has been found out anti-Helicobacter therapy is less effective in the patients with chronic gastritis and concomitant type 2 diabetes mellitus that is accompanied by the enhancement of bacterial overgrowth syndrome and associated with worse clinical dynamics compared to patients without carbohydrate metabolism disorders.
EFFECT OF TRANSCRIPTION FACTOR KAPPA B INHIBITORS ON METABOLIC AND STRUCTURAL DISORDERS IN BONE TISSUE UNDER COMBINED EXCESSIVE INTAKE OF FLUORIDE AND SODIUM NITRATE
Authors: Kovalova I.O. , Kostenko V.O.
Published: April 2019

This experiment carried on 40 white Wistar rats aimed at studying the effect produced by inhibitors of the nuclear transcriptional factor kappa B (NF-κB) activation on the mechanisms of metabolic and structural disorders in the femoral bones and vertebrae under combined surplus fluoride and sodium nitrate intake. It has been found out that co-administration of sodium fluoride (10 mg/kg body weight) and sodium nitrate (500 mg/kg of body weight) for 30 days disrupts the autoregulation mechanism of nitrogen monoxide (NO) level in the femoral bones of the test rats that is manifested by an increase in the activity of total NO synthase and its inducible isoform against the background of a decrease in the total arginase activity and the activity of the constitutive NO synthase isoenzymes. Under these conditions, there has been observed the growth in the concentration of free hydroxyproline, N-acetylneuraminic and hexuronic acids in the femoral bones and vertebrae that is indicative of depolymerization of collagen, sialoglycoproteins and proteoglycans, decrease in bone mass, their density, mineral saturation, strength (the Simon index elevated). Inhibitors of NF-κB activation (ammonium pyrolidine dithiocarbamate and a water-soluble form of quercetin) restore the autoregulation mechanism of the NO level in the rats’ femoral bones that is accompanied by a decrease in the total activity of NO synthase, the activity of its inducible isoform, an increase in the total arginase activity and by limited peroxinitrite formation. Ammonium pyrolidine dithiocarbamate and a water-soluble form of quercetin have been shown to result in lowering in the content of free hydroxyproline, N-acetylneuraminic and hexuronic acids in bones that confirms their effectiveness as a means for correcting depolymerization of collagen, sialoglycoproteins and proteoglycans. There has been found their property to promote the growth of bone mass and density of the femurs and vertebrae.
CURRENT DIFFERENCES IN PSYCHOSOCIAL MALADJUSTMENT AMONG INTERNALLY DISPLACED PERSONS WITH NEUROTIC PATHOLOGY
Authors: Halchenko A.
Published: April 2019

In recent years, 1.5 million internally displaced persons from Donetsk, Luhansk regions and Crimea have been registered in Ukraine. Half a million people of working age experienced psychological traumas due to the need to migrate. This psychological traumatic experience can produce a significant impact on the further life and all spheres of activity. Better understanding of the patterns underlying the formation of psychosocial maladjustment in forced migrants with neurotic disorders, early diagnosis of adjustment disorders in this group of population, effective psychosocial rehabilitation and prevention of traumatic experience can contribute into solving the pressing issues of modern psychiatry: to prevent efficiency failure, disturbances in social functioning and lower quality of life. The purpose of the work was to determine the dominant variants and severity of psychosocial maladjustment in internally displaced persons with neurotic pathology. We examined 78 persons who are internally displaced persons from Donetsk, Luhansk regions and Crimea diagnosed to have pathologies of the neurotic register. According to the results obtained, it has been found out that the nosological structure of the internally displaced persons is represented mainly by adjustment disorders in 28 persons (35.9%), mixed anxiety-depressive disorder in 25 (32.1%) and somatoform disorders in 13 (16, 7%) individuals. Psychosocial maladjustment was detected in a large majority of patients, in 69 (88%) people. Maladjustment in the main group reached mainly moderate and severe levels, while in the control group we revealed mild and moderate levels of the maladjustment. The combined variants of psychosocial maladjustment have been found out to prevail in patients with non-psychotic mental disorders of the main group, among them the leading place it taken by the information sphere.
PROGNOSTIC MARKERS IN IMMUNOHISTOCHEMICAL DIAGNOSIS OF METASTASES OF COLORECTAL PHENOTYPE CARCINOMA OF UNKNOWN PRIMARY
Authors: Poslavska O.V.
Published: April 2019

Most metastases of cancers of unknown primary (80% -85%) are known as having unfavourable prognostic variants due to their large extant and low susceptibility to the therapy. Studies of prognostic immunohistochemical markers will provide an opportunity to understand the biological features of the rapid dissemination of individual colorectal phenotypes. In recent decades, p53 and Ki-67, the most popular antibodies have been investigated as prognostic factors for colorectal cancer. The p53 protein is a regulatory protein that is at the crossroads of cell division and cell death. The goal of this study is to explore the expression features of prognostic immunohistochemical markers Ki-67, p53, β-catenin, AMACR (p503s), HER2-new in carcinomas of unknown primary of the colorectal phenotype compared with primary tumours of the colon, to improve diagnostic algorithms. Materials and methods. A study of biopsy material taken from 37 patients aged 28 to 81 years (mean 58.46 ± 12.28; median 58), group 1, with metastases without primary localization was carried out; the immunohistochemical investigation revealed adenocarcinomas of the colorectal phenotype CK20 + / CDX2 + / CK7; the investigation of postoperative material in 41 patients aged 27 to 76 years (mean 60.56 ± 12.81; median 64), group 2, revealed primary colon tumour. Results. Positive focal expression of p53 was found in the colorectal cancers of the proximal sections (located to the right), it is they that more often have microsatellite instability, compared to distal carcinomas. Amplification of the Her-2-new gene (expression at the level of 2+ and 3+) was found in 35% (13 of 37) of metastasis of colorectal cancers, and in almost 15% (6 of 41) of primary colon adenocarcinomas that suggests the appropriateness in applying targeted therapy.Conclusions. Nuclear translocation of β-catenin, positive “focal” expression of p53 and amplification of the Her-2-new gene are statistically significantly more common in colorectal phenotype metastases compared with primary colon adenocarcinomas (all р> 0.05).
COMPREHENSIVE EXAMINATION OF PATIENTS WITH PATHOLOGICAL FACIAL SCARS
Authors: Avetikov D.S. , Bukhanchenko O.P. , Ivanyts’ka O.S. , Havryl’iev V.M. , Skrypnyk V.М.
Published: April 2019

Introduction. The urgency of the issue on diagnosis of pathological head and neck scars has resulted from a growing prevalence of pathological scars. Quite often, patients with pathological scars require psychological rehabilitation. The purpose of our study is to improve the effectiveness of the treatment of scars by identifying a specific type of scar and taking into account the psychological state of the patient. Materials and methods. Under our supervision, there were 60 people with head and neck scars aged 20-50 years (mean age 31.2 ± 11.1 years). In addition, the study involved 20 healthy individuals (mean age 30.9 ± 10.7 years). Clinical examination of patients was supplemented by digital imaging of graphic images in the RGB system in Adobe Photoshop. An integral part of the clinical examination of patients with head and neck scars was a detailed study of their individual personality characteristics. The study included the techniques to assess patients’ general health condition, general activity and emotional state; a questionnaire for evaluating mental stress and the "Integrative Anxiety Test" was also used.

Results. By applying the RGB colour system, statistically significant differences in colour indices were revealed. It was established that all the indicators of intensity of spectral radiation tended to decrease: the red colour indicator tended to decrease on average by 4 units, the same was relevant for the green spectrum indicator. The average values of the reduction of the blue colour intensity were 10 units.

Mental and emotional states of the patients with pathological scars are characterized by specific features that distinguish them from the emotional state of healthy individuals. Significant differences in the emotional states between the emotional states of the patients and healthy individuals included both quantitative (higher rates of most of the investigated parameters) and qualitative parameters (different proportion of components in the structure of the emotional state). The obtained data testify that the patients with pathological scars tend to respond to the traumatic situation (including the situation of the disease) by intense feeling of physiological and psychological discomfort, depressed mood, mental stress, anxiety, hypochondria, exaggeration of negative experience.

Conclusions. The application of the RGB system in the diagnosis of pathological scarring in the face allows us to reliably determine the type of scar, and depending on the scar type to choose the optimal method of the therapy. Inclusion in the comprehensive examination of psychodiagnostic methods is sufficiently feasible and can contribute to the development of an integrated approach in the treatment of pathological scars.
Support for regional export activities (cases of regions leaders in growth of export quota)
Authors: Shirokova E. Yu.
Published: April 2019

Foreign trade activity has a strong influence on the socio-economic development of the country. In turn, each of the constituent entities of the Russian Federation contributes, in accordance with the specifics of its location, existing on the territory of the natural resource potential. Due to the fact that the role of the regions in the implementation of the development strategy of the country’s foreign trade is increasing, it is necessary to investigate the problems of foreign trade regulation in order to achieve the required results. To assess the effectiveness of foreign policy conducted, the ranking of all Russian regions for 2010 – 2016 was carried out. in terms of the openness of the economy and the contribution of exports to the size of the gross regional product is estimated. The study analyzed the export activities of the leading regions in the growth of export quotas. Existing measures of state support of foreign trade in the Republic of Buryatia, Magadan region, Kamchatka, Primorsky and Khabarovsk Krai, Orenburg, Rostov, Arkhangelsk, Vologda, Murmansk and Kemerovo regions are considered. The article discusses the impact of government measures to support exports on regional development and suggests ways to adjust them. The study is based on general scientific methods of comparison, analysis and synthesis. As an information base, we used statistical data from state statistical bodies, a strategy for the socio-economic development of regions, and official data from the sites of regional state executive bodies.
On the issues of industrialization of economy in the context of Presidential «may decrees»
Authors: Lukin E. V.
Published: April 2019

The article shows that the implementation of the new may presidential decree on Russia’s entry into the top five economies of the world and ensuring economic growth above the world requires a significant transformation of the state economic policy. Based on the assessment of the results of socio-economic development of the Russian Federationin 1991-2017 and based on the opinions of authoritative domestic and foreign scientists, the conclusion is made about the exhaustion of the existing export-raw material model. Its main limitations – high dependence on the external environment and the results of export-import activities, the narrowness of the domestic consumer and investment market-are systematized. To change the situation, it is proposed to adjust the state policy aimed at increasing the income of all economic entities (population, companies, state) by forming their own value chains that produce goods for final consumption. It is shown that the basis of these transformations should be the policy of a new industrialization of the economy, which will help to overcome the technological gap and create their own high-tech industrial capital. The key characteristics of the neoindustrial growth paradigm based on high labor productivity as a complex expression of intensification of all factors of production are briefly described.
Intangible personnel motivation in order to improve the efficiency of the organization
Authors: Magzumova N. V. , Kolesnik A. E. , Avanesov A. S.
Published: April 2019

The article reveals the content of the concept of non-material motivation of the staff, what goals it carries out and the ways of its implementation. Among the bright advantages of non – material motivation of employees is healthy competition in the team and unity of all employees. There are four types of non-material motivation on which managers rely: social motivation, psychological motivation, moral motivation and organizational motivation Any company can apply different methods of motivation, regardless of the number of employees or volume of production. The use of various methods of motivation contribute not only to increase the productivity of employees of the organization, but also increase the efficiency of the organization as a whole. There is also the fact that it is the use of non-material motivation that allows you to see a person from the other side and help him uncover unused resources. The difficulty of using this method of influencing the activities of employees lies in the fact that it is not always possible for the manager to choose a method depending on the individual characteristics of a person.
The auction trade in Russia
Authors: Saprykina V. Yu. , Milvanov V. F.
Published: April 2019

Auction trading is a form of market relations, it is a specially organized operating market in which transactions of purchase and sale are carried out by price competition between buyers. The auction is an open auction of various valuable items: collectible and antique items, precious products, coffee, tea, fur, other raw materials and various finished goods.

Conclusion auction trade to a new level contributed to the rapid development of the Internet. Every year the number of online auctions and the number of their participants is growing. Online auctions are one of the most important and promising business models in the world economy. The importance of online auctions is determined by the fact that they are a cost-effective tool in the modern mechanism of market economy, and their implementation contributes to a significant increase in the effectiveness of foreign economic activity of enterprises, the formation of conditions for the development of modern infrastructure of foreign trade.

To date, the share of online auctions in the turnover of e-Commerce is up to 25% in theUSand up to 40% inGermany. Despite the fact that the auction is widespread in the world, inRussiatheir conduct for a long time was extremely limited. The reform of the Russian economy has caused the rapid development of auction activities in all its forms.
Budaya Patriarki dan Kekerasan Terhadap Perempuan (Sejarah dan Perkembangannya)
Authors: Israpil Israpil
Published: April 2019

Masyarakat Indonesia secara kultural memang sangat kental dengan adat patriarki. Patriarki adalah konsep yang digunakan dalam ilmu-ilmu sosial, terutama dalam ilmu Antropologi. Konsep patriarki dan kekerasan terhadap perempuan menjadi pembahasan utama dalam makalah ini. Budaya patriarki secara turun temurun membentuk perbedaan perilaku, status dan otoritas antara laki-laki dan perempuan, distribusi kekuasaan laki-laki memiliki keunggulan dibanding dengan perempuan dalam satu atau lebih aspek, seperti penentuan garis keturunan (keturunan patrilineal eksklusif dan membawa nama belakang), hak-hak anak sulung, otonomi pribadi dalam hubungan sosial, partisipasi dalam status publik dan politik. Laki-laki memonopoli seluruh peran. Hubungan yang timpang itu seringkali memunculkan konflik di dalam masyarakat, terutama konflik dalam rumah tangga yang berujung pada tindak kekerasan terhadap perempuan.
Islam dan Kristen Di Tanah Bugis Soppeng (Sejarah Dan Perkembangannya)
Authors: Arafah Sitti
Published: April 2019

Penelitian ini bertujuan mengambarkan  sejarah dan perkembangan Islam dan Kristen di Tanah Bugis Soppeng. Jenis penelitian ini adalah  kualitatif menggunakan metode pengumpulan data observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa Islam dan Kristen menjadi anutan bagi masyarakat Bugis di Tanah Soppeng, yang nota bene bahwa orang Bugis tentulah beragama Islam, namun tidak demikian adanya di Tanah Bugis Soppeng. Tampak bahwa Kekristenan di Sulawesi Selatan lebih dahulu masuknya agama Islam sebagai agama resmi di seluruh kerajaan di Sulawesi Selatan. Kristen masuk di Sulawesi Selatan sekitar abad- ke 15-16 khususnya  Katolik yang berlangsung lebih 100 tahun 1530-an-1668). Sedangkan Islam masuk di Sulawesi Selatan disebarkan oleh tiga datuk pada akhir abad ke- 16. Namun demikian walaupun kehadiran agama Kiristen di Sulawesi Selatan, namun pada kenyataan bahwa masuknya Kristen dan Katolik di Tanah Bugis Soppeng diperkirakan tahun 1935-1940, sehingga Islam jauh lebih dahulu menjadi agama anutan masyarakat.
Memahami Konsep Matematika dengan Quantum Learning dan Quantum Teaching
Authors: Fatimah Andriani , Rahman Ulfiani , Prasasti Andi Ika
Published: April 2019

Artikel ini membahas tentang perbandingan penerapan model pembelajaran Quantum Learning dan Quantum Teaching terhadap kemampuan pemahaman konsep matematika siswa kelas VIII SMP IT Wahdah Islamiyah Makassar. Penelitian ini bertujuan untuk (1) mengetahui kemampuan pemahaman konsep matematika siswa yang diajar dengan menerapkan model pembelajaran Quantum Learning; (2) mengetahui kemampuan pemahaman konsep matematika siswa yang diajar dengan menerapkan model pembelajaran Quantum Teaching; (3) mengetahui perbedaan yang signifikan antara kemampuan pemahaman konsep matematika melalui penerapan model pembelajaran Quantum Learning dengan model pembelajaran Quantum Teaching. Pendekatan penelitian ini adalah kuantitatif dengan jenis Quasi Experiment dengan design Nonequivalent Control Group Design. Sampel pada penelitian ini adalah siswa Kelas VIII B2 dan Kelas VIII B3 yaitu 60 orang dari jumlah keseluruhan siswa kelas VIII 120 orang. Instrumen penelitian yang digunakan adalah soal tes kemampuan pemahaman konsep matematika, lembar observasi dan dokumentasi. Data dianalisis dengan analisis statistik deskriptif dan statistik inferensial. Hasil penelitian menunjukkan bahwa (1) kemampuan pemahaman konsep matematika siswa yang diajar dengan menerapkan model pembelajaran Quantum Learning mengalami peningkatan; (2) kemampuan pemahaman konsep matematika siswa yang diajar dengan menerapkan model pembelajaran Quantum Teaching mengalami peningkatan; (3) terdapat perbedaan yang signifikan antara kemampuan pemahaman konsep matematika melalui penerapan model pembelajaran Quantum Learning dengan model pembelajaran Quantum Teaching.

 

Kata Kunci: Kemampuan Pemahaman Konsep Matematika, Quantum Learning, Quantum Teaching
Análisis del ciberperiodismo en México, con énfasis en el estado de Sinaloa
Authors: López Ayala Mario Guadalupe , Osuna Flores Israel
Published: April 2019

Se hace una revisión y análisis del ciberperiodismo en México con  énfasis en el estado Sinaloa, tomando en cuenta los principales trabajos de reconocidos investigadores en el ciberperiodismo en Iberoamérica y México y  se realizó una investigación  sobre el estado actual del periodismo digital  en el estado de Sinaloa. En él se contempla los principales antecedentes del periodismo digital a nivel nacional y estado; así como,  la discusión sobre la problemática actual y perspectivas a futuro. En  México, se han dado casos aislados de trabajos de investigación sobre el desarrollo y actuación de los periódicos digitales mexicanos, registrándose apenas unos pocos textos acerca de esta actividad informativa; todos ellos desarticulados, por lo que no se puede considerar que exista un claro intento a nivel nacional para develar las particularidades del ciberperiodismo mexicano; la academia mexicana tiene un déficit en este punto. Son pocos los trabajos que describen el desarrollo y análisis del periodismo digital en México y escasos antecedentes para el estado de Sinaloa; y que en ambos casos,  se tiene una discontinua información, observándose  que el ciberperiodismo en México y en Sinaloa está dentro de las primeras fase de su desarrollo. Una tendencia interesante detectada en este análisis fue que varios de los cibermedios mejor valorados pertenecen a la zona noroeste de México, conformada por los estados de Sinaloa, Sonora y Baja California Norte, lo que indica una tendencia de competencia positiva en esa región y un claro avance en el estado de Sinaloa, México.
Editorial Volume 4 (1) 2019 - Development and evolution of the journal
Authors: Gómez Oscar R.
Published: April 2019

This editorial describes our journal’s evolution since 2016 as well as the actions taken by the editorial committee to achieve objectives that have allowed us to be among the leading journals in the world. It also presents our goal for 2020: To keep on funding authors by covering the processing, editing, and layout charges and to allocate more financial resources to fund authors’ research devoted to make visible problems and solutions related to suffering caused by social inequalities.
EXPERIMENTAL RESULTS OF SOFTWARE ALGORITHMIC SYNCHRONIZATION OF DISTRIBUTED RADIO SYSTEM WITH MOBILE CARRIERS
Authors: Kryuchkov I. V. , Noniashvili M. I. , Skachkova A. I. , Filatov A. A.
Published: April 2019

Introduction. One of the classes of modern radio engineering systems are systems with spatial diversity of transmitting, receiving or transceiving elements. In such systems, an increase of the information content is achieved by signal coprocessing ensuring synchronization in time and phase of the carrier oscillation. Currently, the researchers do not pay enough attention to the requirements for the accuracy of synchronization of distributed systems of different applications, as well as simple and affordable ways to synchronize them.

Objective. The paper main objective is the search for technical solutions for clock and phase synchronization without atomic frequency standards and external sources of coordinate-time information.

Methods and materials. The paper considers a distributed radio engineering system with non-rigid structure. Each element of the system has reference signal from its own crystal oscillator. The oscillators are not physically aligned. The phases of their oscillations are periodically compared by the method of two-way transmission of synchronizing signals (from one element to another and vice versa). The synchronization technique (software algorithmic approach) is reduced to the coprocessing signal correction according to estimated frequency (phase) drifts. The testing of the proposed technical solution is presented on a hardware model consisting of ten receiving and transmitting modules.

Results. The experiment showed that RMS of synchronization errors does not exceeded 12 degrees by phase (for VHF), or 0.2 ns by time. These results are acquired for spatial diversity up to several hundred meters, mutual speed of the modules up to several meters per second and may be extended for higher frequencies (in particular, UHF).

Conclusion. The paper proposes a method of multilateral propagation to synchronize distributed radioengineering systems. Combined with software algorithmic technique this method enables to obtain synchronization accuracy in real-time sufficient for coherent diversity technique.