bluuebunny/crossref_metadata_2025 huggingface dataset:
Kajian Tingkat Kebisingan di Kawasan Pendidikan SMP Negeri 5 Kota Sorong
Authors: Widodo Slamet , Manaf Murshal , Kastono Kastono
Published: May 2023

Sekolah adalah tempat berlangsungnya proses belajar mengajar. Salah satu factor untuk mencapai kondisi lingkungan belajar yang baik adalah terhindar dari masalah kebisingan. Sekolah yang berada dekat dengan jalan raya akan sangat mengganggu aktivitas siswa yang berlangsung. Adapun gangguan yang sering ditemui di sekolah – sekolah adalah gangguan kebisingan yang berasal dari aktivitas lalu lintas. Oleh sebab itu, penelitian tentang Kajian Tingkat Kebisingan di Kawasan Pendidikan SMP Negeri 5 Kota sorong yang berlokasi di Jalan Basuki Rahmat KM 12,5 Kota Sorong. Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar tingkat kebisingan yang terjadi pada sekolah SMP Negeri 5 Kota Sorong dan bagaimana pengaruhnya terhadap (persepsi) konsentrasi belajar siswa di Kawasan Pendidikan SMP Negeri 5 Kota Sorong. Pengukuran kebisingan lingkungan dilakukan selama 2 minggu menggunakan alat Sould Level Meter pada 11 titik sampling untuk kemudian dihitung nilai Leq nya. Tingkat ketergangguan dianalisis berdasarkan kuisioner yang di bagikan kepada 100 responden sebagai sampel. Berdasarkan hasil pengukuran, hari, rentang waktu dan titik lokasi dengan tingkat kebisingan tertinggi yaitu pada hari senin pukul 17.00-17.10 di titik 1 (Halaman Depan Sekolah (1)) kebisingan di sekolah tersebut telah memenuhi standart baku mutu tingkat kebisingan yang ditetapkan oleh KepMenLH No. 48 Tahun 1996. Didapatkan data bahwa tingkat kebisingan tertinggi berada pada titik yang berada di dekat jalan dan akan semakin berkurang tingkat kebisinganya pada titik yang berada jauh dari jalan. Berdasarkan hasil analisis kuisioner, sebanyak 44% responden terganggu dengan kebisingan yang terjadi.
Sistem Informasi Pengelolaan Service Komputer Berbasis Web Di Central Media Computer Palopo
Authors: Khair M Ummul , Dani Ahmad Ali Hakam , Muhallim Muhlis
Published: May 2023

Penelitian ini bertujuan Merancang sistem informasi pengelolaan service komputer berbasis web di Central Media Computer Palopo dan Implementasi sistem informasi pengelolaan service komputer berbasis web di Central Media Computer Palopo. Adapun metode penelitian yang digunakan ialah metode kualitatif dengan Teknik pengumpulan data menggunakan metode observasi, wawancara, kuesioner, studi pustaka. Dalam tahapan pembuatan sistem informasi ini menggunakan metode pengembangan sistem waterfall. Sistem yang diusulkan dalam aplikasi ini adalah user dapat mengakses informasi dan mengecek status kepemilikan service mampu melakukan interaksi perbaikan alat tanpa harus datang ke tempat service. Dengan adanya sistem informasi berbasis web yang ada pada Central Media Computer ini memudahkan bagi seluruh pelanggannya. Dari hasil pengujian sistem menggunakan pengukuran skala likert menunjukkan tingkat kelayakan sebesar 64,8%. Hasil dari uji validitas instrument adalah valid untuk tiap butir soal Nilai rxy dibandingkan dengan rtabel. Nilai rtabel 0,279 dengan taraf signifikansi 5%. Hasil dari uji realibilitas instrument adalah 0,985 reliabel.
Aplikasi Multimedia Pembelajaran Pengenalan Komponen Komputer dan Simulasi Perakitan CPU (Studi Kasus SMAN 3 Palopo)
Authors: Febriani Reskika , Suppa Rinto , Dani Ahmad Ali Hakam
Published: May 2023

Penelitian ini bertujuan untuk membangun Aplikasi Multimedia Interaktif Pengenalan Komponen Komputer dan Simulasi Perakitan CPU dan mengetahui kualitas dari Aplikasi Multimedia Interaktif Pengenalan Komponen Komputer dan Simulasi Perakitan CPU. Metode penelitian yang digunakan ialah metode research and development dengan teknik pengumpulan data menggunakan metode wawancara, kuesioner, dan studi pustaka. Adapun software yang di gunakan dalam perancangan dan pengimplementasi sistem menggunakan Adobe Animate. Aplikasi Multimedia Interaktif Pengenalan Komponen Komputer dan Simulasi Perakitan CPU meliputi pembahasan materi tentang perangkat keras, perangkat lunak, bagian-bagian komputer disertai latihan soal untuk melihat sejauh mana pemahaman siswa. Aplikasi telah diujicobakan oleh satu ahli materi dengan memperoleh hasil 80% dengan kategori baik. Ujicoba pengguna dilakukan pada siswa di SMAN 3 Palopo yang berjumlah 30 orang dengan memperoleh hasil 75% dan terletak pada kategori baik.
Klasifikasi Stadium Kanker Serviks Menggunakan Non-Deterministic Finite State Automata
Authors: Asrun Budyanita , Irmayani Irmayani
Published: May 2023

Kanker serviks atau kanker leher rahim adalah suatu penyakit yang menyerang sistem reproduksi pada wanita.Kanker ini adalah kanker yang terjadi pada area leher rahim yaitu bagian rahim yang menghubungkan rahim bagian atas dengan vagina. Kanker serviks disebabkan infeksi virus HPV(Human Papilloma Virus) atau virus papiloma manusia. HPV menimbulkan kutil pada pria maupun wanita, termasuk kutil pada kelamin yang disebut kondiloma akuminatum. Hanya beberapa saja dari ratusan varian HPV yang dapat menyebabkan kanker.Kanker serviks atau kanker leher rahim bisa terjadi jika terjadi infeksi yang tidak sembuh-sembuh untuk waktu lama. Sebaliknya, kebanyakan infeksi HPV akan hilang sendiri, teratasi oleh sistem kekebalan tubuh. Konsep Automata dapat diterapkan dalam membantu memprediksi diagnosa awal tingkat stadium kanker serviks yang diderita oleh pasien berdasarkan keluhan yang diderita oleh pasien. Penelitian ini akan menghasilkan output tingkat klasifikasi stadium kanker. Penerapan automata digunakan untuk mengenal dan menangkap pola. Adapun dalam merancang dan mendesain digunakan model Non-Deterministic Finite State Automata (NFA).
Penerapan Konsep Non-Deterministic Finite Automata dalam Diagnosa Penyakit Jantung
Authors: Asrun Budyanita , Irmayani Irmayani
Published: May 2023

Penyakit jantung merupakan salah satu penyakit yang mematikan di dunia. Serangan jantung mendadak seringkali merupakan pertanda terjadinya penyumbatan pembuluh darah yang menyebabkan aliran darah ke jantung menjadi terhambat. Untuk itu diperlukan suatu sistem konsep ilmu komputer yang dapat digunakan dalam membantu tenaga medis dalam mendiagnosa awal penyakit tersebut, sehingga pasien bisa lebih cepat menerima penanganan yang tepat. Non-Deterministic Finite  Automata (NFA) merupakan salah satu konsep  algoritma yang dapat diterapkan untuk memprediksi awal jenis penyakit jantung yang diderita oleh pasien berdasarkan data gejala atau keluhan dari pasien. Tujuan penelitian ini untuk membuat dan merancang pemodelan Non-Deterministic Finite Automata (NFA) yang  akan menghasilkan output berupa jenis penyakit jantung yang diduga diderita oleh pasien.
Aplikasi Antrian Online Berbasis Android (Studi Kasus: Antrian Puskesmas Bua Kabupaten Luwu)
Authors: Pitaloka Andi Nadya Bestari , Suppa Rinto , Dani Ahmad Ali Hakam
Published: May 2023

Penelitian ini bertujuan untuk merancang sebuah Aplikasi Antrian Online yang Berbasis Android pada Puskesmas Bua Kabupaten Luwu agar mempermudah pasien dalam mengantri yang lebih efektif. Metode pengembangan yang digunakan adalah metode prototype yang terdiri dari tujuh tahapan, yaitu pengumpulan kebutuhan, membangun prototyping, evaluasi prototyping, coding, uji system, evaluasi sitem, penggunaan sistem. Metode penelitian yang digunakan ialah metode kualitatif dengan teknik pengumpulan data menggunakan metode observasi, wawancara, studi pustaka, kuesioner. Aplikasi antrian online ini dalam perancangannya menggunakan metode UML (unifield modelling language) yang terdiri dari use case diagram, activity diagram, dan sequence diagram. Hasil penelitian aplikasi antrian online di Puskesmas Bua Kabupaten Luwu telah diujicobakan sehingga diperoleh hasil yang berjalan dengan baik.
Nikah Muda : Antara Solusi Versus Belenggu Patriarki (Studi Kasus di Desa Bandang Laok Bangkalan)
Authors: Shalvena Aura Azzura  , Khoirun Nisa  , Devy Kusuma Dian Andani
Published: May 2023

The meaning of customs and traditions passed down from ancestors is something that is difficult to just leave even though times have changed because they are deeply rooted and practiced continuously. One example is early marriage among the Madurese community, especially in Bandang Laok Bangkalan Village. Among the Madurese, their children, especially girls, choose to get married immediately rather than continue their studies or work. This study aims to find out how the perspectives of the Madurese people and ordinary people regarding early marriage in Madura, where this phenomenon is still common, especially in rural areas. The researcher also relates it to the Symbolic Interactionism Theory with the concept of mind, self and society to be analyzed from a sociological point of view. In this study, researchers used literature studies to obtain data and indirect observations. The results of this study are that this phenomenon is a real form of human unconsciousness about themselves, maybe they agree about arranged marriages carried out by their parents or family, but actually they are also depressed.
Vinculación con la sociedad en la formación tecnológica. Aprendizaje en el contexto post COVID-19
Authors: Peñaloza Montenegro Byron Calixto , Catota Mesías Vicente David , López Moreno Jorge Luis
Published: May 2023

La presente tiene como objetivo principal exteriorizar el aprendizaje de la ejecución de proyectos de Vinculación con la Sociedad, mediante una investigación de campo no experimental de tipo descriptiva, tras la ejecución de los proyectos de vinculación con la sociedad 2021 y 2022 en el Instituto Superior Tecnológico Universitario España, ISTE. Las organizaciones beneficiarias están enmarcadas en la oferta académica de Administración, Administración Financiera, Marketing y Desarrollo de Aplicaciones Web. La investigación desarrolló un análisis de la información levantada para la ejecución de proyectos, mediante la aplicación de la técnica de encuesta, con un instrumento avalado por juicio de expertos. En este proceso, se destaca la aprobación de los proyectos mediante la firma de cartas de aceptación. Así, se afirma el crecimiento exponencial de estudiantes técnicos y tecnológicos en Ecuador y el incremento de ejecución de proyectos, beneficiarios y entidades cooperantes. Finalmente, el contexto COVID-19 abrió la oportunidad de mejorar procesos vinculatorios desarrollados en la educación superior tecnológica, con la aplicación de estrategias, herramientas y recursos actuales.
PEMIMPIN PEREMPUAN PERSPEKTIF BUYA HAMKA DALAM TAFSIR AL-AZHAR
Authors: Syawqibik Ahmad
Published: May 2023

Skripsi ini ditulis bertujuan untuk mengetahui tentang legalitas pemimpinperempuan dalam tafsir al-Azhar karya Hamka. Hal ini sangat penting karena banyak dari kaum perempuan yang meginginkan jabatan pemimpin yang diemban laki-laki. Penelitian ini berbeda dengan penilitian yang dilakukan oleh Rohmat Sraiffudin (Tahun 2017) yang mengerucutkan pembahasannya pada status keislaman seorang pemimpin itu sendiri. Penelitian ini sama dengan penelitian Fitriyani (Tahun 2014) dalam pengangkatan temanya, yaitu Kepemimpinan perempuan. Penelitian ini menggunakan jenis penelitian kualitatif dengan menjadikan Tafsir Al-Azhar sebagai sumber data premier. Adapun teknik pengumpulan data yang digunakan dalam penelitian adalah metode dokumentasi. Untuk mencapai suatu kesimpulan yang konkrit maka penulis menggunakan metode deskriptif-analisis, yaitu dengan cara mengumpulkan data-data yang ada kaitannya dengan permasalahan dan memeriksa secara konseptual makna yang terkandung dalam istilah-istilah yang digunakan untuk mendapatkan kejelasan makna yang sebenarnya. Berdasarkan metode tersebut, penulis memperoleh suatu kesimpulan bahwa Hamka mengatakan seluruh manusia baik laki-laki ataupun perempuan diciptakan dari satu diri yang sama, sama-sama diturunkan ke bumi sebagaimana Adam dan Hawa, dan sama-sama mendapat tugas. Akan tetapi meskipun keduanya memikul tugas tidaklah sama masing-masing dari tugas mereka itu. Salah satunya adalah tugas memimpin yang merupakan tugas seorang laki-laki, bukanlah tugas seorang perempuan.
MODERASI DALAM AL-QUR’AN (Diskursus Kisah-Kisah 25 Rasul)
Authors: Sofiuddin Sofiuddin
Published: May 2023

Jurnal ini berjudul "MODERASI DALAM AL-QUR’AN (Diskursus Kisah-Kisah 25 Rasul)". Penelitian ini dibatasi pada lingkup, tema dan objek. Pembatasan dari segi tema yaitu potret komprehensif tentang konsep moderat dalam al- Qur’an, sedangkan objek penelitiannya yaitu kisah-kisah 25 Rasul yang mencerminkan sikap moderat. Dalam upaya penelitan skripsi ini, penulis ingin memberikan paparan data tentang kisah- kisah 25 Rasul yang dalam hidupnya mereka semua telah mengajarkan kepada seluruh umat di dunia berprilaku baik, mempunyai sikap teladan dan berfikir secara matang sebelum melakukan sesuatu dengan mengusung semangat moderasi.Peran penting penelitian ini untuk memberikan kontribusi pengetahuan tentang sikap-sikap moderat yang berdasarkan keteladanan 25 Rasul, disamping untuk mengisi ruang kosong yang belum pernah diteliti oleh peneliti terdahulu (yakni para peneliti secara intens yang ingin mengembangkan wacana Islam moderat yang bisa ditransmisikan pada seluruh elemen masyarakat). Dengan demikian penulis memilih judul “MODERASI DALAM AL-QUR’AN (Diskursus Kisah-Kisah 25 Rasul)” yang menurut penulis kiranya penelitian ini dapat dijadikan bahan acuan berfikir masyarakat secara luas.
METODE PENAFSIRAN MUHAMMAD BIN ALI AL-BALANSI DALAM TAFSIR MUBHAMAT AL-QUR’AN
Authors: Hamzah Hamzah , Haris Noor
Published: May 2023

Kajian ini berjudul “Metode penafsiran Muhammad bin Ali al-Balansi dalam Tafsir Mubhamat Al-Qur’an”, tema ini diangkat karena keresahan penulis terhadap perhatian salah satu ilmu Al-Qur’an, yaitu mubham yang seringkali agak kurang diperhatikan. Karena dengan ilmu mubham ini, penjelasan Al-Qur’an akan lebih jelas dengan Asbab al-Nuzulnya.  Pemilihan Tafsir Mubhamat Al-Qur’an dikarenakan satu kitab tafsir ini yang spesifik membahas tentang kata-kata mubham yang ada dalam Al-Qur’an dan kitab ini tergolong langka dalam penelitian ilmiah, khususnya di bangku perkuliahan.Dalam kajian ini membahas tentang pengertian mubham, alasan-alasannya secara umum beserta contohnya, namun lebih khususnya dan spesifiknya adalah mengkaji metode yang digunakan oleh Muhammad bin Ali al-Balansi dalam menafsirkan Tafsir Mubhamat Al-Qur’an dengan menggunakan metode penelitian Deskriptif Analisis.          Setelah dianalisa, Mubham dalam Al-Qur’an disebabkan tujuh alasan yang menjadikan rahasia kenapa subjek atau tokoh dalam Al-Qur’an tersebut disamarkan. Sedangkan metode yang digunakan Muhammad bin Ali al-Balansi dalam menafsirkan Tafsir Mubhamat Al-Qur’an adalah menggunakan metode Ijmali dan Muqaran, serta menggunakan pendekatan bi al-Ma’tsur dan bi al-Ra’yi sekaligus.
La importancia del conocimiento del entorno para la construcción de identidad y sentido de pertenencia a través del ABP (Aprendizaje Basado en Proyectos) en el segundo ciclo de Educación Infantil
Authors: Díaz Montero Amelia , Quintero Cabello Ana
Published: May 2023

En el presente trabajo se pone de manifiesto la importancia de trabajar el área de conocimiento del entorno en la etapa de Educación Infantil. Los niños necesitan establecer vínculos afectivos con las personas que les rodean. El pueblo es el lugar idóneo para ello, sentir que son importantes y queridos por su comunidad. El sentido de comunidad influye en las relaciones entre los miembros de un mismo colectivo y se nutren del arraigo, apoyo y sentimiento de interdependencia. Se desarrolla una propuesta educativa, “Conoce tu pueblo, Marchena”, basada en la metodología ABP (Aprendizaje Basado en Proyectos) donde el menor aprenderá de forma activa, autónoma y experiencial, siendo en todo momento el promotor de su propio aprendizaje. El ABP fomenta el desarrollo integral del alumnado respetando los diferentes ritmos de aprendizaje y sus intereses por su entorno más inmediato. Mediante esta propuesta los alumnos conocerán mejor su pueblo, Marchena, y se reconocerán como marcheneros. Sentirse marchenero contribuirá a una mejor autoestima y autoconcepto desarrollando lazos afectivos con sus vecinos. El conocimiento del entorno más cercano, su pueblo, Marchena, conocer su cultura, costumbres y tradiciones contribuirá al desarrollo de la identidad y sentido de pertenencia al mismo.
Eficacia del ejercicio terapéutico en niños con leucemia linfoblástica aguda durante el período de administración de quimioterapia: Revisión Bibliográfica
Authors: Ortega Valle David , Muñoz Fernández María Jesús
Published: May 2023

El cáncer infantil es el proceso neoplásico que incluye a niños y adolescentes, siendo éste la principal causa de muerte en esta población. La leucemia es considerada el cáncer más común en este grupo. La quimioterapia es el tratamiento principal para abordar este tipo de neoplasias, ocasionando diversos efectos adversos sobre el organismo. El ejercicio terapéutico es usado comúnmente en adultos con cáncer para combatir la sintomatología derivada del tratamiento médico, es por ello que el objetivo de esta revisión ha sido conocer la eficacia de los efectos del ejercicio terapéutico en niños que padecen LLA durante el período de administración de quimioterapia, frente a los cuidados tradicionales. Metodología: se ha realizado una revisión bibliográfica de la literatura actual en cinco bases de datos electrónicas documentales, entre diciembre de 2021 hasta marzo de 2022: “Cinhal”, “Cochrane”, “PEDro”, “Pubmed”, “Scopus” y “Web of Science” (WOS). Utilizando solamente ECAs, aplicándose criterios/filtros de inclusión y exclusión. Resultados: el ejercicio terapéutico, en ciertas modalidades, demostró que podría ser, según algunos autores, beneficioso para las variables calidad de vida, la fuerza, la capacidad cardiovascular, aumentando la respuesta inmunológica y disminuyendo la fatiga. Conclusión: según los estudios analizados, el ejercicio terapéutico de diferentes tipos, demostró cierta eficacia en las variables medidas, siendo un método seguro y prometedor para pacientes con LLA durante la administración de quimioterapia.
El Patio del Recreo en educación infantil: ¿espacios creativos o espacios olvidados?
Authors: Vargas Martínez María , Jiménez López Juan José
Published: May 2023

El patio del recreo es considerado como un lugar de desfogue, algo que en cier-ta manera es así, pero sobre todo debemos de valorarlo como un lugar de aprendizaje educativo y creativo. Podemos observar cómo desde hace bastantes años, la distribución de este espacio y su uso no ha cambiado. Es a partir de esta reflexión donde nos planteamos nuestra investigación. Destacaremos los diferentes aspectos educativos que influyen en los niños y su aprendizaje. Consideramos que debería llegar el momento de que se tengan en cuenta las nuevas formas de aprendizaje en los diferentes espacios que podrían transformar las escuelas: los patios. La actitud y motivación del docente es fundamental para el proceso de enseñanza-aprendizaje para tener presente este es-pacio como un tercer contexto de enseñanza. Con la realización de este estudio se propone conocer cuál es la realidad que acompaña a este espacio y las problemáticas que se plantean en el mismo, algo que se realizará a través de un análisis detallado.
Influence of organizational culture factors on employee performance at PT. Bank Syariah Mandiri Malang branch
Authors: Rosyidi Mochamad Anwar
Published: May 2023

This research is to find out how the influence of organizational culture on employee performance. In the context of empowering human resources, in order to produce professional employees with high integrity, it is necessary to have a company standard reference imposed by something. The standard reference is an organizational culture that systematically guides employees to improve their performance. One of the elements that influence employee behavior is the environment of the employee itself, which in this case is the surrounding corporate culture. Organizational culture can influence the way employees behave, the way they describe their work, the way they work with colleagues, and the way they view the future with broad insights defined by their norms, values, and beliefs. Organizational culture determines what can and cannot be done by members of the organization, determines the normative limits of the behavior of members of the organization, determines the nature and form of organizational control and supervision, determines the managerial style that can be accepted by members of the organization, determines the right way of working, and so on. -other. Thus the data is explained through a description of the frequency and proportion. Data analysis using multiple linear regression analysis techniques, and determination. To test the hypothesis is done by using the f test and t test. This study shows that (1) organizational culture has a simultaneous effect on employee performance. (2) there is a dominant influence between trustworthiness and tabligh culture on employee performance. The dominant variable affecting employee performance is the tabligh variable.
Effect of fundamental variables on stock prices (studies on mining companies that go public on the Jakarta stock exchange)
Authors: Hidayah Akhmad Nur
Published: May 2023

This study aims to determine the effect of fundamental variables consisting of Debt To Equity Ratio (DER), Return On Equity (ROE), Dividend Per Share (DPS), Earning Per Share (EPS), and Price Earning Ratio (PER) on stock prices. The shares in question are shares of mining companies that go public on the Jakarta Stock Exchange. To find out the effect of fundamental variables on stock prices, multiple linear regression analysis was used. The results of the multicollinearity test showed that the DPS and EPS variables were collinear, so that the DPS variables were excluded from the regression model. The results of multiple linear regression analysis show that DER, ROE, EPS and PER simultaneously have a significant effect on stock prices. Then EPS partially has a significant and dominant influence on stock prices. This means that EPS is the main consideration for investors in investing in stocks, especially in mining companies. Therefore EPS can be used as input in predicting stock prices for investors and issuers. For investors who will invest, it is necessary to make EPS as a reference in making investment decisions. For issuers who want to increase their share price in the capital market, they can take steps to improve the company's performance by increasing their EPS because the company sells shares with the consequence that it must meet the investor's goal, namely to get maximum profit. This is the company's obligation to investors. If the investor's goals cannot be met, the company's credibility will decrease.
Influence of the marketing mix on the decision to purchase Oepet Oe cigarette products in the people of Pamekasan district
Authors: Asepta Uki Yonda
Published: May 2023

The purpose of this research is to analyze the significant effect simultaneously of the marketing mix on the purchasing decision of Oepet Oe cigarettes. purchasing decisions for Oepet Oe cigarettes. Companies that are able to demonstrate effective performance will be able to face competitive conditions between industrial environments. The condition of the business environment that continues to develop with a high level of competition requires companies to be able to overcome the impact of these changes on the company's future. To be able to face a competitive level of competition, companies need to develop and apply competitive advantage on an ongoing basis, for this reason there must be careful planning by taking into account the company's industrial (internal and external) environmental factors. The results of this study aim to find out how the consumer's response or consumer's decision to purchase an item is seen from the way the marketing is done so that customers have an attraction to these commodities both by planning and promotion carried out, therefore the method used in this research is the survey method. . According to Singarimbun and Effendi (1995: 3) survey research is research that takes a sample from a population and uses a questionnaire as a data collection tool with the main sample in this study being consumers of these goods.
Readiness of the national textile industry in facing trade liberalization
Authors: Ming Tjia Chen
Published: May 2023

This study found that there are three alternative strategies, namely: strength-opportunity, weakness-opportunity, weakness-threats. The support needed by the business world from the government is: R & D development, information on market opportunities, ease of export, sources of funds other than the banking industry to carry out machine restructuring. The textile industry on the world stage is no longer a new figure but an old face. The term textile that we usually hear comes from the Latin word "texere" which means to weave. Textile is a commodity that has wide usage. Most of the output from the textile industry by the community is used to meet clothing needs. However, apart from being used for clothing, textiles can also be used for other things, such as medicine, the car industry. The car industry uses textile products in the form of upholstery covers. Textile products used in the medical world include: surgical threads, bandages. How a country takes advantage of the new, overcomes the challenges that arise depending on the strengths & weaknesses inherent in the respective national textile industries. This study aims to describe what strategies can be carried out by the national textile industry to obtain maximum benefits from the elimination of textile export quotas. The research data will be analyzed using the SWOT analysis method.
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
Authors: Jain Kanishk , Marunde Matthew R , Burg Jonathan M , Gloor Susan L , Joseph Faith M , Poncha Karl F , Gillespie Zachary B , Rodriguez Keli L , Popova Irina K , Hall Nathan W , Vaidya Anup , Howard Sarah A , Taylor Hailey F , Mukhsinova Laylo , Onuoha Ugochi C , Patteson Emily F , Cooke Spencer W , Taylor Bethany C , Weinzapfel Ellen N , Cheek Marcus A , Meiners Matthew J , Fox Geoffrey C , Namitz Kevin EW , Cowles Martis W , Krajewski Krzysztof , Sun Zu-Wen , Cosgrove Michael S , Young Nicolas L , Keogh Michael-Christopher , Strahl Brian D
Published: May 2023

In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation (e.g. K9ac, K14ac, K18ac) is linked to increased H3K4me3 engagement by the BPTF PHD finger, but it is unknown if this mechanism has a broader extension. Here, we show that H3 tail acetylation promotes nucleosomal accessibility to other H3K4 methyl readers, and importantly, extends to H3K4 writers, notably methyltransferase MLL1. This regulation is not observed on peptide substrates yet occurs on the cis H3 tail, as determined with fully-defined heterotypic nucleosomes. In vivo, H3 tail acetylation is directly and dynamically coupled with cis H3K4 methylation levels. Together, these observations reveal an acetylation ‘chromatin switch’ on the H3 tail that modulates read-write accessibility in nucleosomes and resolves the long-standing question of why H3K4me3 levels are coupled with H3 acetylation.
Neural dynamics underlying self-control in the primate subthalamic nucleus
Authors: Pasquereau Benjamin , Turner Robert S
Published: May 2023

The subthalamic nucleus (STN) is hypothesized to play a central role in neural processes that regulate self-control. Still uncertain, however, is how that brain structure participates in the dynamically evolving estimation of value that underlies the ability to delay gratification and wait patiently for a gain. To address that gap in knowledge, we studied the spiking activity of neurons in the STN of monkeys during a task in which animals were required to remain motionless for varying periods of time in order to obtain food reward. At the single-neuron and population levels, we found a cost–benefit integration between the desirability of the expected reward and the imposed delay to reward delivery, with STN signals that dynamically combined both attributes of the reward to form a single integrated estimate of value. This neural encoding of subjective value evolved dynamically across the waiting period that intervened after instruction cue. Moreover, this encoding was distributed inhomogeneously along the antero-posterior axis of the STN such that the most dorso-posterior-placed neurons represented the temporal discounted value most strongly. These findings highlight the selective involvement of the dorso-posterior STN in the representation of temporally discounted rewards. The combination of rewards and time delays into an integrated representation is essential for self-control, the promotion of goal pursuit, and the willingness to bear the costs of time delays.
Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program
Authors: Smith Christina M. , Grow Edward J. , Shadle Sean C. , Cairns Bradley R.
Published: May 2023

The embryonic transcription factor DUX regulates chromatin opening and gene expression in totipotent cleavage-stage mouse embryos, and its expression in embryonic stem cells promotes their conversion to 2-cell embryo-like cells (2CLCs) with extraembryonic potential. However, little is known regarding which domains within mouse DUX interact with particular chromatin and transcription regulators. Here, we reveal that the C-terminus of mouse DUX contains five uncharacterized ∼100 amino acid (aa) repeats followed by an acidic 14 amino acid tail. Unexpectedly, structure-function approaches classify two repeats as ‘active’ and three as ‘inactive’ in cleavage/2CLC transcription program enhancement, with differences narrowed to a key 6 amino acid section. Our proximity dependent biotin ligation (BioID) approach identified factors selectively associated with active DUX repeat derivatives (including the 14aa ‘tail’), including transcription and chromatin factors such as SWI/SNF (BAF) complex, as well as nucleolar factors that have been previously implicated in regulating the
Dux
locus. Finally, our mechanistic studies reveal cooperativity between DUX active repeats and the acidic tail in cofactor recruitment, DUX target opening, and transcription. Taken together, we provide several new insights into DUX structure-function, and mechanisms of chromatin and gene regulation.
Bacterial DNA on the skin surface overrepresents the viable skin microbiome
Authors: Acosta Ellen M , Little Katherine A , Bratton Benjamin P , Lopez Jaime G , Mao Xuming , Payne Aimee S , Donia Mohamed , Devenport Danelle , Gitai Zemer
Published: May 2023

The skin microbiome provides vital contributions to human health. However, the spatial organization and viability of its bacterial components remain unclear. Here, we apply culturing, imaging, and molecular approaches to human and mouse skin samples, and find that the skin surface is colonized by fewer viable bacteria than predicted by bacterial DNA levels. Instead, viable skin-associated bacteria are predominantly located in hair follicles and other cutaneous invaginations. Furthermore, we show that the skin microbiome has a uniquely low fraction of viable bacteria compared to other human microbiome sites, indicating that most bacterial DNA on the skin surface is not associated with viable cells Additionally, a small number of bacterial families dominate each skin site and traditional sequencing methods overestimate both the richness and diversity of the skin microbiome. Finally, we performed an in vivo skin microbiome perturbation-recovery study using human volunteers. Bacterial 16S rRNA gene sequencing revealed that, while the skin microbiome is remarkably stable even in the wake of aggressive perturbation, repopulation of the skin surface is driven by the underlying viable population. Our findings help explain the dynamics of skin microbiome perturbation as bacterial DNA on the skin surface can be transiently perturbed but is replenished by a stable underlying viable population. These results address multiple outstanding questions in skin microbiome biology with significant implications for future efforts to study and manipulate it.
Bacterial DNA on the skin surface overrepresents the viable skin microbiome
Authors: Acosta Ellen M , Little Katherine A , Bratton Benjamin P , Lopez Jaime G , Mao Xuming , Payne Aimee , Donia Mohamed S , Devenport Danelle , Gitai Zemer
Published: May 2023

The skin microbiome provides vital contributions to human health. However, the spatial organization and viability of its bacterial components remain unclear. Here we apply culturing, imaging, and molecular approaches to human and mouse skin samples, and find that the skin surface is colonized by fewer viable bacteria than predicted by bacterial DNA levels. Instead, viable skin-associated bacteria are predominantly located in hair follicles and other cutaneous invaginations. Furthermore, we show that the skin microbiome has a uniquely low fraction of viable bacteria as compared to other human microbiome sites, indicating that most bacterial DNA on the skin surface is not associated with viable cells Additionally, a small number of bacterial families dominate each skin site and traditional sequencing methods overestimate both the richness and diversity of the skin microbiome. Finally, we performed an in-vivo skin microbiome perturbation-recovery study using human volunteers. Bacterial 16S rRNA gene sequencing revealed that, while the skin microbiome is remarkably stable even in the wake of aggressive perturbation, repopulation of the skin surface is driven by the underlying viable population. Our findings help explain the dynamics of skin microbiome perturbation, as bacterial DNA on the skin surface can be transiently perturbed but is replenished by a stable underlying viable population. These results address multiple outstanding questions in skin microbiome biology with significant implications for future efforts to study and manipulate it.This study provides a crucial update to the skin microbiome paradigm by showing that viable bacteria of the skin microbiome are primarily localized to hair follicles and other sub-cutaneous structures rather than the skin surface. The native distribution of skin-associated bacteria has not been previously evaluated, and here we show that the skin surface has few intact bacteria while deeper structures are replete with bacterial contents. We used orthogonal approaches to evaluate the source of bacterial DNA and the dynamics of bacterial repopulation on the skin surface to develop an updated model of the skin microbiome. By adjusting the current understanding of the skin microbiome to match this model, we will be able to address outstanding questions in the field.
Inositol pyrophosphate dynamics reveals control of the yeast PHO starvation program through 1,5-IP8 and the SPX domain of Pho81
Authors: Chabert Valentin , Kim Geundon , Qiu Danye , Mayer Lydie Michaillat , Jessen Henning Jakob , Mayer Andreas
Published: May 2023

Eukaryotic cells control cytosolic inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impacts. Phosphate homeostasis depends on a conserved signaling pathway including inositol pyrophosphates (PP-IPs) and SPX receptor domains. Since cells synthesize various PP-IPs and SPX domains bind them promiscuously, it is unclear whether a specific PP-IP regulates SPX domains in vivo, or whether multiple PP-IPs act as a pool. In contrast to previous models, which postulated that phosphate starvation is signaled by increased 1-IP
7
production, we now show that the levels of all detectable PP-IPs of yeast, 1-IP
7
, 5-IP
7
and 1,5-IP
8
, strongly decline upon phosphate starvation. Among these, specifically the decline of 1,5-IP
8
triggers the transcriptional phosphate starvation response, the PHO pathway. 1,5-IP
8
inactivates the cyclin-dependent kinase inhibitor Pho81 through its SPX domain. This stimulates the cyclin-dependent kinase Pho85/Pho80 to phosphorylate the transcription factor Pho4 and repress the PHO pathway. Combining our results with observations from other systems we propose a unified model where 1,5-IP
8
signals cytosolic phosphate abundance to SPX proteins in fungi, plants, and mammals. Its absence triggers starvation responses.Cytosolic P
i
is of prime importance for cellular bioenergetics because P
i
influences free energy of nucleotide hydrolysis and the metabolite fluxes through glycolysis and oxidative phosphorylation. Eukaryotic cells signal P
i
via SPX domains binding critical ligands, inositol pyrophosphates (IP
7
, IP
8
), which control P
i
homeostasis through a network of target proteins that import, export, store or detoxify P
i
. Studies with different systems failed to yield a coherent model on this regulation.We performed the first time-resolved profiling of the full isomer spectrum of inositol pyrophosphates and dissected the isomer that is relevant to intracellular P
i
signaling. Our results support a unified model of P
i
signaling across all eukaryotic kingdoms, which is in accord with the fundamental importance of P
i
management for metabolism.
The Generation of White Mountain
Authors: Sutherland Suzanne
Published: May 2023

This chapter examines the “generation of White Mountain,” which refers to members of a transregional military elite who fought at White Mountain or were inspired to join or otherwise support Catholic imperial forces in the aftermath of the battle. Historians of the eighteenth- and nineteenth-century Austro-Hungarian Empire have long noted the commitment of the Austro-Hungarian army's international officer corps to the Habsburg dynasty as one of the army's most distinctive features. An examination of one especially successful cohort of officers in imperial service, Italian noblemen, indicates that the origins of these relationships can be traced back to the late sixteenth and early seventeenth centuries. The Battle of White Mountain and the ensuing Thirty Years' War were an especially critical turning point in Habsburg military culture. The aftermath of Catholic victory at White Mountain also included a decade of acquisitive behavior and inconclusive fighting that Raimondo Montecuccoli's patrons found ways to benefit from. Harsh conditions meant that many Italian military entrepreneurs failed to achieve the glory they originally sought. Nonetheless, they remained loyal to the Habsburgs and developed an aristocratic identity revolving around service to the dynasty.
From Battlefield to Court
Authors: Sutherland Suzanne
Published: May 2023

This chapter focuses on Raimondo Montecuccoli's diplomatic career. It looks at his 1653–55 posts as imperial diplomat to Queen Christina of Sweden in Uppsala and the Spanish Netherlands and his 1666 assignment to greet Emperor Leopold I's bride, the Spanish infanta Margarita Teresa, at the Italian port of Finale. Each of these assignments played a role in his advancement, because they widened and enriched his web of patrons, opening further pathways into a lively Catholic Habsburg political universe with hubs in Vienna, Madrid, Rome, and Brussels. Although military entrepreneurs have rarely been studied outside of their military contexts, the chapter argues that they are ideal figures to analyze in order to shed light on political activity during these decades because they inhabited both battlefield and court. Montecuccoli's journals, alongside official instructions, letters, military treatises, and other documents, indicate that officers were part of a larger, mobile group of elites who exchanged scholarship and intelligence, competed over status, participated in intrigue, and volunteered for war.
Epilogue
Authors: Sutherland Suzanne
Published: May 2023

This epilogue reviews how Raimondo Montecuccoli's experiences in imperial service from the 1630s through the 1670s are a testament to the incremental nature of rewards available to talented and well-connected military entrepreneurs capable of adapting to changes in warfare and committed to long-term Habsburg service. After his death, Montecuccoli's reputation was initially a product of how contemporaries read accounts of the 1663-64 war against the Ottomans, above all his own. Montecuccoli's works, as well as the example he had set in his lifetime, had a major impact on the generation of officers who succeeded him in the imperial army, the “generation of 1683.” These men witnessed the Ottoman Siege of Vienna or were inspired by the dramatic relief of the siege to participate in the subsequent conquest of Eastern Europe. Two slightly later figures, Eugene of Savoy and Luigi Ferdinando Marsigli, show how the patterns of expertise and professionalism embodied by Montecuccoli developed into the eighteenth century.
Old Woes and New Pains
Authors: Ding Iza
Published: May 2023

This chapter provides necessary historical background on China's state environmentalism and makes three main points about environmental pollution and governance in China. First, environmental degradation existed long before its impact entered the public consciousness. Second, rising scrutiny was not merely a product of objective pollution levels, but also of international and domestic political shifts. Third, the development of contemporary China's environmental bureaucracy over the past four decades followed certain predictions of typology. The chapter points out how environmental governance in China was largely inert as the bureaucracy neither possessed the capacity that would allow it to govern, nor confronted the public scrutiny inciting it to act. It points out that China's environmental state has at times switched gears toward substantive governance, but substantive environmental governance remains sporadic.
PERFORMANCE AND PERFORMANCE
Authors: Ding Iza
Published: May 2023

This chapter reflects the double-meaning of the word performance, noting how separation of appearance and substance follows a long tradition among Enlightenment thinkers. It explores how performative governance relates to the Chinese Communist Party's (CCP) ongoing battle against bureaucratic formalism and the potential for a collapsing together of the bureaucratic and the political in our present information age. It also reviews the intellectual separation of what is commonly called “government performance” from the government's theatrical representation of its performance. The chapter uses “performative governance” to describe the theatrical representation of good governance, especially when substantive performance is wanting. It shows how environmental bureaucracy engaged in performative governance to appease its scrutinizing citizen audience when it lacked the ability to fulfil its function of improving environmental outcomes.
Shenzhen and the Diasporic Relationship
Authors: Trémon Anne-Christine
Published: May 2023

This chapter provides a background on the changing relationship between Pine Mansion, a Hakka lineage–village community in Shenzhen, and its emigrants and their descendants in Tahiti and around the world. It reviews how the community members' migratory past shapes their outlook on the diasporic relationship and how they reinterpret their relations with their overseas kin in relation to China's changing position in the world. It also initiates the reconceptualization of the act of leaving the country, citing inhabitants of Shenzhen that see relatives in the diaspora as remote and emigration as passé. The chapter shows how the relationship between the emigrant community and its migrants and their descendants has altered in a context of accelerated change. It highlights that the revived form of the lineage is not identical to that of the past and is more involved than the reestablishment of Confucian modes of social organization.
A Globalized Lineage
Authors: Trémon Anne-Christine
Published: May 2023

This chapter is based on the material in the lineage genealogy and recent surveys in the Hakka lineage–village that estimated the number of kin living abroad and in Hong Kong. It discusses how the comparison of these two sources reveals the extent to which ties with relatives who are not only geographically remote but also genealogically distant have relaxed. It also distinguishes between two main migration periods: the first is at the end of the nineteenth century and the two decades following the revolution of 1911, while the second follows the advent of the Communist regime in 1949. The chapter highlights the difference between these two periods in terms of the mobilization of kinship ties. It mentions a hypermobile class of entrepreneurs that differ from those of the older diaspora and are the focus of the current Chinese authorities' discourse on patriotic migrants.
Reversed Feng Shui and Sociodicies of (Im)Mobility
Authors: Trémon Anne-Christine
Published: May 2023

This chapter considers narratives and statements about geomancy (feng shui), the desirability of emigration and the possibility of return, and donations from overseas. Geomancy and donations from overseas are indicative of how Pine Mansioners question the distribution of value between themselves and those who have left. It highlights that the improvement in local livelihoods reduces the incentive to migrate and engenders sociodicies of (im)mobility. The chapter reviews moralized comparisons of people's trajectories according to whether they have stayed in the village or left. It analyzes the implicit moral condemnation of migration by those who have stayed, and the local, more than national, morality revealed by the way some illustrious returnees are considered exemplary figures. How the acts of migrating and returning, or not returning, are morally valued, vary notably according to historical period and social class.
Returning to One’s Roots Through Journeys and Quests
Authors: Trémon Anne-Christine
Published: May 2023

This chapter is based on the visit of a group of Tahitian Chinese to their villages of origin, who experienced the journey as a return although none of them were first-generation emigrants. It considers the travel itself as a continuation of their quest for identity and a response to an absence of knowledge transmission within the family. Because many of the villages of origin have now vanished, searching for their roots is becoming increasingly difficult for diasporic visitors. The chapter examines the main elements that account for the Tahitian Chinese's approach that is largely based on searching for clues and signs, making the journey itself much like a detective game. One of the travelers' paradoxical uses of the Tahitian term mana, the magical power and energy emanating from the ancestors, reveals the tension at the heart of the diasporic relationship.
The Global Health Frontier
Authors: Brada Betsey Behr
Published: May 2023

This chapter examines how Eastern University Medical School (EUMS) educators and trainees and Referral Hospital's medical staff employed and contested local and resource-limited in their efforts to position themselves as experts and assert the value of their own labor. For EUMS personnel, global health emerged in contrast to a parochial, outdated, morally suspect biomedical practice ascribed to “local doctors.” The chapter considers the conceptualization of global health as a frontier or imaginative project rather than an arrangement of biological threats and expert practices. It shows how American medical personnel's ability to do global health rested on their assertion of temporal and spatial contrasts between “global” and “local” and to enforce the boundaries of these categories. The chapter argues that “global health” and the “resource-limited settings” in which it takes place are not born.