bluuebunny/crossref_metadata_2025 huggingface dataset:
Colchicine for the treatment of cardiovascular diseases: old drug, new targets
Authors: Andreis Alessandro , Imazio Massimo , De Ferrari Gaetano Maria
Published: August 2020

Well known in past centuries as a herbal remedy for osteoarticular pain and commonly used in the treatment of gout and familial Mediterranean fever, colchicine has an emerging role in the setting of cardiovascular diseases. Its unique properties not only target the key mechanisms of recurrent inflammation underlying pericardial syndromes but also inflammation within atherosclerotic plaques, atrial fibrillation recurrence and adverse ventricular remodelling leading to heart failure.

The effect of colchicine in the treatment of cardiovascular diseases along with essential pharmacology will be discussed, reviewing the most important and recent clinical studies. Colchicine is a valuable, well tolerated and inexpensive drug in the setting of cardiovascular diseases.
Emerging therapy in light-chain and acquired transthyretin-related amyloidosis: an Italian single-centre experience in heart transplantation
Authors: Di Nora Concetta , Sponga Sandro , Ferrara Veronica , Patriarca Francesca , Fanin Renato , Nalli Chiara , Lechiancole Andrea , Vendramin Igor , Livi Ugolino
Published: August 2020

Aims

The prognosis for patients affected by light-chain cardiac amyloidosis and acquired transthyretin-related (TTR) amyloidosis is poor. Heart transplantation (HTx) could improve prognosis also enabling autologous stem cell transplantation (ASCT) in the first group.

Methods and results

A total of 36 patients affected by systemic amyloidosis have been referred to our centre from 2009 to 2019. Of these, nine had cardiac involvement: seven by light-chain amyloidosis and two by acquired TTR amyloidosis. None died while waiting for HTx. A specific internal protocol useful to select candidates and to monitor the organ involvement after HTx was developed. Median age at diagnosis was 54 years and 66% were male. The most common short-term complication after HTx was renal failure (44%), followed by acute cardiac rejection more than 2R (22%). ASCT was performed in six out of seven light-chain cardiac amyloidosis patients, with a median time of 6 months after HTx. Two patients affected by light-chain cardiac amyloidosis died due to amyloidosis relapse: one before undergoing ASCT. After a median follow-up of 31 (7–124) months, 1- and 5-year survival was 88 and 66% in the cardiac light-chain amyloidosis group. Conversely, 1- and 5-year survival was 100% in the acquired TTR amyloidosis group.

Conclusion

HTx may represent a valuable option in carefully selected patients. ASCT after HTx is an effective treatment that could decrease amyloidosis relapse in light-chain cardiac amyloidosis patients. A multidisciplinary approach is mandatory to select the best candidates and to obtain the most effective results with a specific surveillance follow-up protocol.
Ovarian remnant syndrome in a cat with ovarian tissue in the omentum
Authors: Fontes Gabrielle S. , McCarthy Robert J.
Published: August 2020

CASE DESCRIPTION

A 2-year-old spayed female domestic shorthair cat was evaluated for recurring estrous behavior after ovariohysterectomy and 2 subsequent exploratory laparotomies.

CLINICAL FINDINGS

Physical examination revealed no abnormalities. A serum sample tested positive for anti-Müllerian hormone and had a progesterone concentration consistent with the presence of an ovarian remnant. Results of abdominal ultrasonographic examination suggested presence of a slightly hyperechoic mass caudal to the left kidney.

TREATMENT AND OUTCOME

Exploratory laparotomy was performed when the cat was showing estrous behavior. Tissues at the right and left ovarian pedicles and the uterine stump appeared grossly normal but were excised and submitted for histologic examination. Two small nodules associated with the omentum were removed, and histologic examination results for one of these nodules indicated ovarian tissue with secondary and graafian follicles. Clinical signs of estrus resolved after surgery, and hormonal assay results were within ranges expected for an ovariectomized cat.

CLINICAL RELEVANCE

To the authors’ knowledge, the present case represented the first clinical report of ovarian remnant syndrome in a cat or dog in which persistent ovarian tissue was not found at the site of an ovarian pedicle. Our findings emphasized the importance of exploring the entire abdominal cavity when evaluating a patient for possible ovarian remnant tissue and confirming the excision of ovarian remnant tissue by histologic assessment.
Relationships Between Fat and Cholesterol Contents and Fatty Acid Composition in Different Meat-Producing Animal Species
Authors: Razmaitė Violeta , Šiukščius Artūras , Šveistienė Rūta , Bliznikas Saulius , Jatkauskienė Virginija
Published: August 2020

The objective of this study was to determine the relationships between intramuscular fat, cholesterol contents and fatty acid composition in the muscles of different animal species. Intramuscular fat, cholesterol and fatty acid composition in 207 muscle samples from 129 animals of different species (pigs, beef cattle, farmed red deer, horses and geese) were determined and analysed. The obtained results indicated unequal relations between intramuscular fat and cholesterol contents and fatty acid proportions in the muscles of different animal species. The increase of intramuscular fat content resulted in higher monounsaturated and lower polyunsaturated fatty acid contents in most muscles of meat producing animals. In all the species higher fatness did not show any increase in cholesterol content and also cholesterol contents were lower as fat increased in m. semimembranosus of pigs and m. pectoralis profundus of horses. The cholesterol content positively correlated with saturated and monounsaturated fatty acids in the longissimus muscle with the lowest fat content found in red deer and beef cattle, whereas the correlations between these measures were negative in m. pectoralis profundus of horses and the breast of goose containing high fat levels. Negative correlations between polyunsaturated fatty acids and cholesterol content were found in the longissimus muscle of red deer and cattle, whereas these correlations in goose breast and horse meat were positive.
Experimental Validation of Equivalent Circuit Modelling of the Piezo-Stripe Harvester Attached to the SFSF Rectangular Plate
Authors: Koszewnik Andrzej
Published: August 2020

Plate-like structures with attached piezo-patch elements are widely used in marine, aerospace and civil infrastructure applications to power small devices with low power demand or used for monitoring of vibration structures. In order to assess the feasibility of an energy harvesting system to generate power output from a harvester, an accurate electromechanical model of the piezo-patch harvester attached to a 2D structure in modal coordinates is required. Taking into account this fact, this study is focused on the analysis of the piezoharvester orientations on the SFSF (Simply Supported-Free-Simply Supported-Free) plate undergoing forced dynamic excitation. The results obtained from the numerical analysis of a smart structure led to determining quasi-optimal piezo-harvester location on the structure, and next, to determining a multi-mode representation of the equivalent circuit model. The experimental set-up carried out on the lab stand properly verified the parameters of the ECM model. Finally, the proposed approach can be used for the structural health monitoring of vibration of some 2D mechanical structures like the front wall of a dishwasher.
Pure Bending of Strip (BEAM) with Crack in Strip of Tensile Stress with Allowance for Plastic Strips Near Crack Tips
Authors: Sulym Heorgij , Opanasovych Viktor , Slobodian Mykola , Bilash Oksana
Published: August 2020

In the article, the pure bending problem for strip (beam) with straight, perpendicular to its axis crack located in the zone of tensile stresses is investigated on the assumption of narrow plastic strips near crack tips. Using methods of the theory of functions of a complex variable and complex potentials, the problem is reduced to the several linear conjunction problems. The solutions of latter problems are obtained in the class of functions confined in the edges of plastic strips. Formulas for the calculation of their lengths are derived. Expressions for the determination of crack tip opening values are written. Numerical analysis of the problem is performed.
An Exploratory Study on the Accuracy of Parts Printed in FDM Processes from Novel Materials
Authors: Nieciąg Halina , Kudelski Rafał , Dudek Piotr , Cieślik Jacek
Published: August 2020

The paper describes the experiment of assessing the chosen geometric characteristics of test models with simple geometry, shaped by the FDM (fused deposition modelling) method of different materials. The influence of the material grade and the degree of infill density on the shrinkage affecting their dimensional deviations and selected surface topography parameters of printed parts was examined and compared. Three different types of materials were used to fabricate the test models, namely HDGLASS and NANOCARBON, two new fibre reinforced composites available in the market and, additionally ABS, a popular monoplastic material. An infill density ratio of 10, 50 and 90% was assumed for each material. Three specimens were made on the same printer for each infill density, which allowed to assess the repeatability of the analysed characteristics. From among many possible shapes of models, a cube was chosen as representing the simplest geometry, facilitating the measurements themselves and the interpretation of the results. New fibre-reinforced materials are more attractive in industrial applications than pure plastics (ABS) due to their mechanical properties or appearance. They are characterized by a relatively low melting point and short cooling time, after which they can return to their original geometry; however, there is a lack of detailed data on the geometric accuracy of parts made of used composite materials. The presented work was to explanatorily broaden the knowledge about the properties of composite made parts. The practical purpose of the research was that on the basis of measurements, it would be possible to indicate among the materials used that particular material whose properties and method of application would allow obtaining the best quality surface and would be the most resistant to thermal loads. An attempt was also made to explain the possible causes of the differences in the observed characteristics of the tested materials.
Temperature-Dependent Fatigue Characteristics of P91 Steel
Authors: Egner Władysław , Sulich Piotr , Mroziński Stanisław , Egner Halina
Published: August 2020

In this paper, the experimental investigations, constitutive description and numerical modelling of low-cycle fatigue behaviour of P91 steel in non-isothermal conditions are presented. First, experimental tests are performed to recognise different aspects of material behaviour. Then, an appropriate constitutive model is developed within the framework of thermodynamics of irreversible processes with internal state variables. The model describes two phases of cyclic softening, related to plastic mechanisms. An important goal of the presented research is to include thermomechanical coupling in the constitutive modelling. Next, the model parameters are identified based on the available experimental data. Some parametric studies are presented. Finally, numerical simulations are performed, which indicate the significant influence of thermomechanical coupling on the response of the constitutive model in thermomechanical fatigue conditions.
Effect of Pressure Fluctuations on the Temperature During Braking
Authors: Topczewska Katarzyna , Zamojski Przemysław
Published: August 2020

The aim of this study is to develop the numerical–analytical model of frictional heating in a pad/disc system during braking including the pressure fluctuations, engendered by the pump in an anti-skid braking operation. For this purpose, the problem of motion and the one-dimensional thermal problem of friction for a semi-space/semi-space tribosystem were formulated and solved. Obtained solutions allow to calculate temperature distribution on the contact surface and inside the friction elements. Thermal analysis was performed for a metal–ceramic pad and a cast iron disc during one-time braking including the time-dependent, oscillating pressure. The influence of amplitude of pressure fluctuations on the temperature variations was investigated, especially on the value of maximum temperature achieved during braking.
Impact of Psychosocial Stress on the Morbidity of Healthcare Professionals
Authors: Boariu Dan-Ioan , Armean Petru
Published: August 2020

We have analysed the impact of psychosocial risks on the health of hospital staff, in an attempt to determine whether there is a correlation between the risk level assessed and the number of days of medical absenteeism through diseases with psychosocial stress as a contributory or aggravating factor. There is a strong correlation between the risk level assessed by sectors of activity and the number of days of medical absenteeism through diseases caused or favoured, potentially aggravated by occupational psychosocial stress.
Quality of Occupational Therapy Services in the Ergotherapy Department of the “Dr. Gh. Preda” Psychiatric Hospital of Sibiu
Authors: Anghel Claudia , Băcilă Ciprian
Published: August 2020

The patients with psychiatric pathology, during the hospitalization in the “Dr.Gh.Preda” Psychiatric Hospital of Sibiu attend to the activities carried out in the ergotherapy department. The complementary therapies are designed to help the patient to integrate socially and professionally easier. To make this possible, the quality of the services provided to the patients is important. We conducted this study in order to evaluate the quality of these services and to find solutions for possible problems. Occupational therapy has had an important place in the history of our hospital, being a department with tradition in which the quality of the services offered has always been emphasized.
Migraine as the First Symptom for Setting a Clinical Diagnosis
Authors: Neagoe Mariana-Alis
Published: August 2020

The migraine is among the most frequent complains of the patients requesting a medical consultation. I am presenting hereby the case of a 34-year old patient, who complained of diffuse migraine followed several weeks later by vomiting and seizures. The brain computed tomography (CT) and magnetic resonance imaging (MRI) examinations indicate an intracranial spread located in the left (temporal) hemisphere, which had a mass effect on the ventricular system. When performing the extemporaneous examination, it was found an anaplastic oligodendroglioma. Subtotal resection under microscopic guidance was performed, as well as radiotherapy and chemotherapy after the surgery. When discharged from hospital, the patient was surgically cured and had an improved neurological state. The repeated checkups (clinical and paraclinical) indicated no signs of local relapse. Approximately 8 years after the first surgery, the patient returned for a check-up, in view of investigations and treatment, while complaining of migraine and a nervousness state that was bothering his family. The brain MRI indicated a large tumour relapse located in the left temporal-hippocampal region. The histopathology examination indicated that it was an anaplastic oligodendroglioma relapse. Surgery was performed and the tumour relapse located in the left temporal-hippocampal region was completely ablated. After the surgery, the patient was conscious and had no movement dysfunctions.
Neurosteroids in Cognitive Disorder - From Well-Known Pharmacological Aspects to a Source of Controversy
Authors: Bătrînu Mădălina-Georgiana , Tero-Vescan Amelia
Published: August 2020

The nervous system is not just a target organ for synthetic steroids. It is also controlled in a certain manner by steroids synthesized de novo in the brain, at the level of both neurones and glial cells. The impressive recent number of literature studies, clearly demonstrates the presence of enzymes necessary for syntheses of central neurosteroids and also the mechanism by which they act. Neurosteroids play a considerable part as an endogenous modulator of brain function and behaviour processes, and the decrease of their concentration can be associated with the pathophysiology of different neurological diseases accompanied by cognitive disorders such as depression, anxiety, schizophrenia, Alzheimer disease.
Charcot Foot, a Rare and Severe Complication of Diabetes Mellitus
Authors: Mihețiu Alin , Matei Ioana , Sandu Alexandra , Rizea Elena , Nicolae Sînziana
Published: August 2020

Charcot foot or Charcot neuropathy is a rare disease found in patients with diabetes mellitus and is characterized by bone damage to the foot leading to deformities, instability, functional impotence and even amputation. The mechanism is still under discussion, without a consensus regarding the pathophysiology of this condition. The treatment is a complex one, non-surgical and surgical, the non-surgical one addressing especially the acute phase of the disease, the surgical one being complex and ranging from osteotomy, debridement, arthrodesis, internal or external fixation or even amputation. A good management of diabetes, of its peripheral complications, an early recognition of the Charcot type foot, prevents the evolution towards this serious condition.
A Peculiar Case of Cutaneous Eyelid Melanoma: Clinicopathological Questions and Therapeutic Challenges
Authors: Ciubotaru Alin Dumitru , Grigoraș Constantin , Leferman Carmen-Ecaterina
Published: August 2020

Primary melanoma of the eyelid is a rare malignant tumour that accounts for <1% of all malignant melanomas and about 1% of malignant tumours of the eyelid. The most common clinical presentation of melanoma is an oval lesion; linear presentation is uncommon. We presented a 79-year-old woman with a several-month history of a rapidly-growing, irregular, linear, pigmented cutaneous lesion on the right lower eyelid, involving the eyelid margin. The lesion measured 2 cm x 0,8 cm x 0,2 cm. Anterior and posterior segments appeared normal in both eyes, without pathological findings on ocular ultrasound examination. After excision biopsy, histopathological examination revealed a nodular melanoma. The case underwent additional investigations for staging and therapy. The current therapeutic strategies in eyelid melanoma include surgical excision, systemic chemotherapy, immunotherapy, targeted therapy or radiotherapy. Despite advanced research methods in the field, the management of eyelid melanoma is still a major challenge.
General and Particular Aspects of Infective Risk in Orthodontics and Dentofacial Orthopedics - Part II
Authors: Mihai Cristina Nicoleta , Stanciu Dragoș , Ciochindă Gabriel , Burlibașa Mihai , Perieanu Viorel ștefan , Păcurar Mariana , Beuran Irina Adriana , Donciu Irina , Ionescu Ileana , Perieanu Mădălina Violeta , Burlibașa Liliana , Tănase Gabriela , Mihai Laura Lelia
Published: August 2020

The infectious risk in the dental practice, including in the orthodontic practice, represents a real danger for both the medical team (orthodontic specialist, dental nurse and dental technician), but also for the patient. But, dental orthodontics and dentofacial orthopedics is a specialty in the field of dentistry with a special content and special instruments and, therefore, by conducting this study, even if it is only preliminary, we set out to highlight a succession of concepts, the objective being to familiarize the specialists in orthodontics and dentofacial orthopedics with certain rules with theoretical and practical character, which aim to prevent and combat the infectious risk in orthodontic practice.
Fabrication of an Occlusal Appliance Using a Fully Digital Protocol: A Technical Report
Authors: Babiuc Iuliana , Ciur Lucian , Păuna Mihaela , Burlibașa Mihai , Tănase Gabriela , Burlibașa Liliana , Donciu Irina , Beuran Irina Adriana , Ionescu Ileana , Ionescu Camelia
Published: August 2020

A good outcome of an occlusal appliance requires a well-adapted device, both in terms of occlusal relations and internal fit, which helps achieve patient comfort and compliance. Digital technology had led to the manufacturing of night guards that display a better accuracy and properties of the resin, ease of fabrication in terms of time and materials and the possibility of duplication. This technical report describes the clinical and laboratory steps that need to be followed to produce an occlusal appliance in a fully digital protocol. Intraoral scans were acquired, as well as digital occlusal records. A virtual 3D dental device was designed using a CAD software, which was later manufactured via 3D printing technology. The occlusal appliance displayed a good internal fit and enhanced properties of the resin. Minimal occlusal adjustments were required to secure functional guidance during protrusive and lateral movements of the mandible.
Population dynamics and the risk of stock extinction of Persian sturgeon (Acipenser persicus Borodin) in the Caspian Sea
Authors: Fazli Hasan , Tavakoli Mahmoud , Khoshghalb Mohammad Reza , Moghim Mehdi , Valinasab Tooraj
Published: August 2020

Persian sturgeon, Acipenser persicus Borodin, has been the most significant proportion of Iranian commercial sturgeon catches in the Caspian Sea over in the last three decades. This endemic species has suffered continuous population declines from the impact of anthropogenic factors. The present study filled in information gaps on underlying population biology parameters, evaluated the population status, and determined the vulnerability risk of the stock extinction of Persian sturgeon in the south Caspian basin of Iran. Growth parameters were L

∞
= 224.7 cm, K = 0.058 years−1, t

0
= -3.4 years. Sexual maturity of 50% for males and females was FL = 127.2 cm and 137.5 cm, respectively. The long-term age composition data showed 35 age groups, and the ages of 14–18 years comprised 80% of the total catch. Natural mortality was 0.123 years−1, and fishing mortality ranged between 0.104 and 0.331 years −1. The total biomass trend decreased and collapsed from 6,071.3 tons in 1990–91 to 144.1 tons in 2014–15. Although >93% of the catch included maturing specimens, the Persian sturgeon stock is now critically endangered because of several anthropogenic factors.
Runt sturgeon – the case study of abnormal growth in Acipenseridae juveniles
Authors: Adamek-Urbańska Dobrochna , Jabłońska Katarzyna , Rzepkowska Małgorzata , Fajkowska Magdalena , Śliwiński Jerzy , Ostaszewska Teresa
Published: August 2020

The occurrence of runt sturgeon in stocks reared in recirculating aquatic systems is highly undesirable for both production and fish welfare. The aim of this study was to describe the anatomopathological and histopathological changes accompanying the phenomenon of runt sturgeon reared in fully controlled recirculating aquatic conditions. These individuals were characterized by emaciation and cachexia. Histopathological analysis indicated severe chronic non-purulent inflammation of the gastrointestinal tract and exfoliation of enterocytes into the lumen, accompanied by chronic, non-purulent pancreatitis. All pathological findings were probably the result of malnutrition, which further escalated into the disorders observed.
Developmental-induced changes of metabolic and antioxidant responses in the skeletal muscles of sea trout (Salmo truttaL.)
Authors: Kurhaluk Natalia , Tkachenko Halyna
Published: August 2020

The goal of the current study was to characterize developmental-induced changes of the metabolic and antioxidant responses in the skeletal muscles of the anadromous sea trout (Salmo truttaL.) from the Baltic Sea and its catchment area rivers. Activities of the metabolic enzymes, i.e., lactate dehydrogenase, succinate dehydrogenase, alanine and aspartate aminotransferases, their ratios representing aerobic, anaerobic, and amino acid metabolisms, the level of the metabolites (pyruvate and lactate), the activities of several key antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, and reductase), and a marker of lipid peroxidation (2-Thiobarbituric acid reactive substances, TBARS) were evaluated. The current study revealed the impact of the sex and different developmental stages of the sea trout (parr, smolts, spawners, adults, and kelts) on the effective formation of adaptive oxygen-dependent mechanisms. A stable developmental-related tendency toward increased lipid peroxidation in muscle tissues was observed. Glutathione peroxidase in muscle tissues played a leading role in the different stages of trout development. A switch of the muscle cytosolic redox potential from the aerobic pathway to anaerobic glycolysis was observed. These results indicated that energy-related cellular components and metabolic enzymes could compensate for adaptive mechanisms without any serious damage to muscle tissues. The differences in the enzyme activities were associated with the reorganization of the energy-related metabolic pathways (anaerobic and aerobic pathways) during spawning. This process was one of the adaptation mechanisms of this fish.
Morphohistology and histopathology of the digestive organs of the deep-water fish greater forkbeard, Phycis blennoides
Authors: Alioua Zakia , Amira Soumia , Semiane Nesrine , Zerouali-Khodja Fatiha
Published: August 2020

The aim of this paper was to report on an examination of the digestive organs in the deep-water fish Phycis blennoides (Brünnich) from Algerian coastal waters. A total of 1,019 specimens (5.7–62.7 cm in total length) obtained from commercial fisheries were examined between December 2013 and May 2017. The anatomical study was conducted using morphometric measurements of different sections of the digestive tract of P. blennoides. The histological features of the digestive tract were examined in the esophagus, stomach, intestine, and pyloric cecum. They were compatible with carnivorous feeding behavior and confirmed by a low intestinal quotient (IQ = 0.72 ± 0.13). The histopathological assessment highlighted the hepatic steatosis and parasitic infestation in its intestine from Anisakis simplex, which also occurs in Algerian coastal waters. According to our knowledge, this paper reports for the first time the morphohistological analysis of the digestive tract of a Phycidae species in Africa and provides the first histopathological assessment of the digestive organs of the greater forkbeard in the southwestern Mediterranean Sea.
Ziziphus mauritiana (Jujube) Seed as a Protein Source in the Diet Promote Growth Performance and Stabilized Hematology, Lipid Profile and Serum Chemistry Profile of Rattus norvergicus
Authors: Alawode Adenike R. , Iyaka Ahmed Y. , Ndamitso Muhammed M. , Anuonye Julian C.
Published: August 2020

The increase search for easily available and cheaper alternative sources of proteins to meet up the increase protein demand necessitated the present study which was design to assess the effects of graded levels of jujube (Ziziphus mauritiana) seed inclusion in the diets of weaners rats. Twenty-five weaner rats were allocated into five groups of formulated diet consisting of treatment 1 - 5 in which soya bean was replaced with Ziziphus mauritiana seed at 0% (control), 25%, 50%, 75%, and 100% respectively for 3 weeks. Effects of the diets on lipid profile, haematology and serum chemistry were evaluated. Rats fed 25%, 50% and 100% Z. mauritiana had significantly higher feed intake and weight gain when compared with the normal control. All levels of inclusion tested increases the concentrations of serum total proteins and bilirubin but decreases the cholesterol and platelet counts when compared with the control. No diet related alterations were recorded for the relative organ’s ratio, aspartate transaminase, alanine transaminase, albumins, urea, creatinine, sodium, chloride, high- and low-density lipoprotein, triglyceride and hematological indices analyzed. However, seed inclusion only at 100% significantly (p<0.05) increases the total white blood cell count and relative liver weight ratio. Ziziphus mauritiana seed possess good dietary protein quality for optimal growth of rats and does not elicit any adverse effect on haematological and serum biochemical indices of organs integrity.
Rosehip (Rosa canina) as a Beneficial Dietary Feed in Poultry Nutrition: Review
Authors: Vlaicu Alexandru P. , Turcu Raluca P. , Panaite Dumitra T.
Published: August 2020

Today the aromatic and medicinal plants have gained more recognition as dietary supplements because they are characterized as natural, safe, eco-friendly, and possess many health-promoting properties, making their ongoing usage part of an emerging field at the cutting edge of science. Rosehip (Rosa canina), a medicinal plant, is widely known as a valuable source of various nutrients and biologically active substances, mostly polyphenols and vitamin C. The chemical composition differs depending on the climate, growing region, cultivation practice, maturity, soil type, harvesting and storage conditions. Over the years, significant variations in vitamins (106-967 mg/100 g), minerals (Fe 59.40-72.90 ppm; Zn 3.69-4.51 ppm; Ca 133.30-146.70 ppm), essential fatty acids (33.8% - 49.7% α-linolenic), phenols (9982 GAE - mg/100 g), antioxidants (lutein, zeaxanthin) among other bioactive components and nutrients have been reported by various researchers. Both in vivo and in vitro studies have shown that rosehip used at an appropriate dose in broilers and laying hens dietary feed, could have some beneficial effects.
Effect of Diet Supplemented with Dennettia tripetala Fruits on Serum Antioxidants and Biochemical Parameters of Albino Rats
Authors: Yetunde Adebiyi H. , Muhammed Dauda , Richard Babatunde O. , Bernard Odey O. , Omolaiye Aderemi C. , Onoruoiza Suleiman I.
Published: August 2020

This study was carried out to determine the effect of dietary supplementation of Dennettia tripetala on some biochemical parameters of rats. Twenty-five rats were used and were divided in to five groups of 5 rats. Group 1 served as control while group 2-5 were fed dietary inclusion of Dennettia tripetala fruits for 28 days. After the feeding trials, the rats were sacrificed and blood was collected for biochemical analyses. The serum concentration triglyceride and glucose were significantly lowered (p<0.05) while total protein, catalase and high-density lipoprotein were significantly higher (p<0.05) in rats fed with the formulated diet. There was no significant difference (p<0.05) in the serum level of superoxide dismutase, albumin, cholesterol and low-density lipoprotein of rats fed with the formulated diet. In conclusion, the study has shown that dietary inclusion of Dennettia tripetala fruits has hypoglycaemic, antioxidant and hypolipidemic effect. Therefore, it may help in the prevention of coronary heart disease, diabetes mellitus and cancer.
Effect of Fires on Certain Properties of Forest Soils in Western Algeria
Authors: Allam Ayoub , Borsali Amine Habib , Kefifa Abdelkrim , Zouidi Mohamed , Gros Raphael
Published: August 2020

Natural disturbances, such as forest fires, cause significant changes in the structure and functioning of semi-arid ecosystems. After such disturbances, the impact on the soil ecosystem in its entirety is misunderstood. In this study, two years after the last fire, changes in the physicochemical and biological properties of Aleppo pine forest soils in the semi-arid zone were observed. Among all physical properties analysed, only the soil moisture remained significantly lower in the burnt zone in contrast to control zone. Considering the chemical properties, the only negatively affected parameter is the rate of organic matter. In terms of biological properties, results showed that the fire caused a significant decrease in soil microorganisms by decreasing basal respiration and microbial biomass. Conversely, the metabolic quotient recorded higher values in the fire zone than in the control zone. These results indicate that microbial communities in semi-arid soils, already stressed by climatic hazards, are very sensitive to the passage of even low-intensity fires.
Evaluation of Properties of Pellets Made of Swine Manure
Authors: Kažimírová Viera , Kubík Ľubomír , Mihina Štefan
Published: August 2020

This paper deals with assessment of density, moisture content and mechanical properties of pellets made of dry swine manure utilizing pellet production line MGL 200. Pellets were subsequently subjected to compressive loading test. Furthermore, the values obtained were measured by means of device Andilog Stentor 1000 and compression diagrams were plotted. In terms of compressive strength, pellet type 1 showed value of 10.47 MPa; pellet type 2 showed value of 6.24 MPa. Considering the elasticity modulus, pellet type 1 showed value of 122.39 MPa; pellet type 2 showed value of 71.12 MPa. Other observed properties included force necessary for 10% compression strain; force in the first maximum of force-strain curve; force in the inflection point of the force-time curve. Results obtained from compressive loading test provide a basis for innovations in pellet production utilizing materials other than wood biomass.
Application of acute whole-body vibration and lower-body exercise: effects on concentric torque in lower-limb muscles
Authors: Hawkey Adam , Dallaway Alexander
Published: August 2020

Study aim: With contrary evidence regarding the effectiveness of acute whole-body vibration training (WBVT) on sporting performance, the current study examined WBVT’s effect on concentric torque of the quadriceps (Q) and hamstrings (H).

Material and methods: Following ethical approval, 11 male team sport players (age: 22.9 ± 3.3 yrs, height: 1.80 ± 0.07 m, mass: 82.5 ± 12.6 kg) completed three separate weekly WBVT sessions. Baseline and post – WBVT intervention measurements of Q and H concentric torque were recorded, using an isokinetic dynamometer, at each session. Isokinetic knee extension and flexion was performed at 180os−1 through 90o range of motion. For the training intervention, vibration amplitude remained at 2 mm, while frequency was set at 0Hz, 30Hz or 50 Hz; randomised so participants experienced one frequency per session. Torque data (Nm) and H and Q ratio (H: Q) were analysed using 3-way and 2-way ANOVA with repeated measures respectively, with three within subjects’ factors: frequency, muscle group and intervention.

Results: Main interaction effect (frequency x muscle group x intervention) was insignificant (P = 0.327). Significant muscle group x frequency (P = 0.029) and muscle group x intervention (P = 0.001) interactions were found. Intervention, regardless of WBVT, significantly increased concentric torque of H (P = 0.003) and significantly reduced concentric torque of Q (P = 0.031). While H: Q x frequency interaction was insignificant (P = 0.262), the intervention significantly improved H: Q (P = 0.001).

Conclusions: Team sport athletes experience a muscle-specific response in peak concentric torque to lower-body exercise. Acute WBVT does not provide additional positive or negative effects on Q or H strength.
Effect of a 5-month exercise program on blood pressure and glucose: A case study of a 68-year-old woman with diabetes mellitus type II and hypertension
Authors: Kekelekis Afxentios , Knechtle Beat , Nikolaidis Pantelis T.
Published: August 2020

Introduction: The aim of the present case study was to examine the effect of a 5-month exercise intervention on glucose and hypertension level of a patient with diabetes mellitus.

Material and methods: A 68-year-old woman (weight 70 kg, height 163 cm) with diabetes mellitus and hypertension performed a 5-month exercise program (two sessions per week with each session lasting 45 min).

Results: A decrease of blood glucose across time was observed, except for after exercise. No change was observed in pre-exercise levels of systolic and diastolic blood pressure across time.

Conclusions: In summary, the present case study showed that an adult woman with diabetes mellitus and hypertension benefited from a 5-month exercise program combining aerobic and resistance training in terms of blood glucose regulation, physical condition and quality of life.
Posture of adolescent volleyball players – a two-year study
Authors: Grabara Małgorzata
Published: August 2020

Study aim: The aim of this study was to assess and compare the posture of male and female adolescent volleyball players and non-training individuals over a 2-year period.

Material and methods: The study group comprised 32 volleyball players and 30 non-athlete peers. Posture was assessed with a photogrammetric method based on the moiré phenomenon. Participants were examined 3 times at the ages of 14, 15 and 16 years. Training experience of the studied volleyball players at the time of the 1st measurement was less than 5 months.

Results: In volleyball players greater asymmetry in the pelvis position was noted (rotation to the right). The right scapula was more outlying than the left, and the right shoulder was more elevated than the left. Volleyball training did not result in sagittal spinal curvatures. Male non-athlete participants exhibited a significant increase in thoracic kyphosis and a decrease in lumbar lordosis over a two-year period.

Conclusion: Volleyball training affects the alignment of the pelvis, shoulder girdle and scapulae. The study revealed a number of differences in spinal curvatures between male volleyball players and non-athletes which could be associated with growth velocity and differences in body height.
β-Elemene inhibits the proliferation and migration of human glioblastoma cell lines via suppressing ring finger protein 135
Authors: Alizada M , Li J , Aslami H , Yang D , Korchuganova T , Xu YH
Published: August 2020

β-Elemene is commonly used as an anti-cancer agent in different types of cancers and its effects on glioblastoma have been studied through different pathways. However, its effect through ring finger protein 135 (RNF135, OMIM 611358) (RNF135), which is upregulated in glioblastomas, has not yet been explored. The current study is focused on the effects of β-elemene on human glioblastoma cell lines U251, U118, A172 and U87 through RNF13 5. A cell counting kit-8 assay and wound healing assay have been utilized to test the proliferation and migration of the cells. Western blot and quantitative real-time-polymerase chain reaction (qRT-PCR) were used to evaluate the level of expression of RNF135. A model of nude mice was used to explore progression of the tumor in vivo. It was observed that increasing treatment time or dose of β-elemene remarkably decreased viability of the cells. The cells that were treated with β-elemene had a much lower speed of moving toward the gap in comparison to untreated cell lines. β-Elemene-treated cells showed a much lower level of expression of RNF135 mRNA than control groups (p <0.05) and the levels of RNF135 protein were lower in the cells treated with β-elemene than in control groups (p <0.05). Moreover, tumor progression in subcutaneous xenograft nude mice was delayed with the injection of β-elemene. Altogether, our findings suggest that β-elemene inhibits proliferation, migration and tumorigenicity of human glioblastoma cells through suppressing RNF135.
Implication of VDR rs7975232 and FCGR2A rs1801274 gene polymorphisms in the risk and the prognosis of
autoimmune thyroid diseases in the Tunisian population
Authors: Mestiri S , Zaaber I , Nasr I , Marmouch H
Published: August 2020

Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are autoimmune thyroid diseases (AITD) that cause hypothyroidism and hyperthyroidism, respectively. The vitamin D receptor (VDR) and the Fey receptor IIA (FcγRIIA), are implicated in the etiology of AITD. This study was conducted to examine the implication of VDR rs7975232 and FCGR2A rs 1801274 variations in the susceptibility and the prognosis of AITD in the Tunisian population. The rs7975232 and rs1801274 (R131H) polymorphisms were analyzed in 162 controls and 162 AITD patients (106 HT and 56 GD) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and amplification of refractory mutation system-PCR (ARMS-PCR), respectively. No significant difference was demonstrated for the rs7975232 between patients and controls. However, a significant association was shown between the rs1801274 polymorphism and AITD or HT in the dominant (p = 0.03 or p = 0.01), codominant (p = 0.019 or p = 0.026) and allelic (p = 0.011 or p = 0.012) models. The rs7975232 was associated with the absence or the presence of anti-thyroglobulin antibody, with the age of AITD and GD patients during the first diagnosis (p = 0.01 and p = 0.009, respectively) and with a high T4 level at the beginning of HT disease. However, the FCGR2A gene polymorphism was associated with a low T4 level at the beginning of GD disease. In conclusion, this study indicates that only the FCGR2A variation could be related to AITD and HT susceptibility and that VDR and FCGR2A gene variations constitute factors to prognosticate the severity of AITD, HT and GD.
A new splice-site mutation of SPINK5 gene in the Netherton syndrome with different clinical features: A case report
Authors: Erden E , Ceylan AC , Emre S
Published: August 2020

Netherton syndrome (NS) is a rare genodermatosis characterized by the triad of ichthyosiform erythroderma, hair shaft abnormality and an atopic diathesis. We report a case of a 20-year-old male patient presented with pruritus, decreased sweat secretion and generalized erythema on his body. Netherton syndrome is caused by mutations in the SPINK5 gene that is a crucial role for epidermal barrier function in the skin. Different clinical and phenotypical features can occur based on various LEKTI-domains mutations. Diagnosis is made by the atopic story, hair shaft abnormality, cutaneous lesions and identification of the SPINK5 gene mutation. In our patient, we detected a new splice site mutation in the SPINK5 gene and pili annulati as hair abnormality. Affected patients are usually misdiagnosed because of cutaneous lesions such as atopic dermatitis. Therefore, each clinical finding should be evaluated together. We aimed to present a case with a new SPINK5 gene mutation and different clinical features in NS.
Ankyloblepharon-ectodermal defects-cleft lip-palate syndrome due to a novel missense mutation in the SAM domain of the TP63 gene
Authors: Tajir M , Lyahyai J , Guaoua S , El Alloussi M , Sefiani A
Published: August 2020

Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome is a rare genetic disease with an autosomal dominant transmission, characterized by several congenital anomalies. Clinical features include ectodermal defects affecting the skin, hair, teeth, nails and sweat glands, associated with typical eyelid fusion in addition to a cleft lip and/or palate. The diagnosis is based on clinical criteria and molecular genetic testing of TP63 gene, the gene related to AEC syndrome. In this context, most reported mutations induce an amino acid change in the sterile alpha motif (SAM) domain, and are predicted to disrupt protein-protein interactions. We here describe the case of a 2-year-old Moroccan girl diagnosed with AEC syndrome on the basis of clinical features. The molecular studies and bioinformatics tools revealed a novel heterozygous missense mutation c.1798G>C (p.Gly600Arg) in exon 14 of the TP63 gene, that was not found in her parents. The molecular analysis and the early diagnosis of this syndrome are important to offer appropriate genetic counseling and management to patients and their families.
The development of orchard fruit-growing in Poland in the period of impact of the Common Agricultural Policy. Production-related and spatial issues
Authors: Wójcik Marcin , Traczyk Anna
Published: August 2020

In the early 21st century, orchard fruit-growing is one of Poland's most rapidly-growing branches of agriculture. The rate and direction of this process of development have obviously been under the fundamental influence of an European Union Common Agricultural Policy (CAP) binding upon Poland since 2004. A series of changes concerning orchard fruit-growing have been ushered in this way, with production intensifying and spatial reorganisation taking place. The work described here has thus sought to determine changes in the level of output achieved by fruit-growing, as well as changes in the distribution of orchards, during the time over which the CAP's instruments have been exerting their influence on Polish agriculture. Research first concentrated on identification of the key CAP instruments capable of influencing the development of orcharding in Poland. Analyses were then carried out in respect of changes in the level of fruit production and the area devoted to orchard cultivation. Impacts on production, including those manifested in increased exports of fresh fruit, are shown to have helped Poland maintain position on European and world markets, with consequences including an increased area assigned to the growing of the most in-demand fruit (i.e. apples and raspberries), in peripheral regions especially. This can therefore be thought to reflect both growing specialisation in farming, and a way of maintaining some economic vitality in rural areas far from large urban agglomerations.
Obesity around Retirement Age: International Comparison Using SHARE
Authors: Pertold Filip
Published: August 2020

In this article, we aim to explain international differences in socio-demographic structure of population among people around retirement age. We further test if transition into retirement is an important factor for obesity. Using Survey of Health, Ageing and Retirement in Europe (SHARE) data, we first document that the Czech Republic has a significant and increasing trend in body mass index (BMI) and obesity (BMI > 29.99) for both men and women aged 50–70 years compared to other countries. Men have much higher level of BMI in comparison to many other European countries, whereas BMI of women is comparable to Estonia and Slovenia. However, we show a little evidence that underlying structure of Czech population with respect to education, occupation, health, age, and so on may explain increasing trend as well as higher level of obesity when compared to other European countries. Furthermore, we show that the transition into retirement is not associated with an increase in BMI. Using fixed effect model, we found that the obesity is directly related to increasing trend in obesity already before entering the retirement.
Influencing Factors of the Informal Investment in Central Europe
Authors: Györfy Lehel , Madaras Szilárd
Published: August 2020

This paper examines the influencing factors of becoming informal investors in two groups of Central European countries: the innovation-driven (Estonia, Latvia, Slovenia and Slovakia) and efficiency-driven economies (Croatia, Hungary, Lithuania, Poland and Romania), based on the GEM (Global Entrepreneurship Monitor) database from 2014. According to the results, in the studied innovation-driven economies of Central Europe the probability of becoming an informal investor is higher for those, who know other entrepreneurs, who are confident in their own entrepreneurial skills, who are in the higher percentile of the household income, who are older and male. The results also suggest that in the studied efficiency-driven economies of Central Europe the probability of becoming an informal investor is higher for those who are confident in the own entrepreneurial skills, who know other entrepreneurs, who are in the higher percentile of the household income, who are older and male. The probability is decreased, if somebody is employed full-time. The study emphasises similarities instead of differences regarding the analysed aspect between the two groups of countries.