bluuebunny/crossref_metadata_2025 huggingface dataset:
Opioidergic effects of transcutaneous electrical nerve stimulation on pain and inflammatory edema in a rat model of ankle sprain
Authors: Elisei Lívia Maria Silvestre , Parisi Julia Risso , Silva Josie Resende Torres , Silva Marcelo Lourenço
Published: October 2017

ABSTRACT Although transcutaneous electrical nerve stimulation (TENS) has been proposed to modulate pain and the mechanisms underlying analgesia remain poorly understood, evidence of anti-inflammatory effect is more limited. The purpose of this study was to examine the opioidergic mechanisms of TENS effects in two different frequencies on pain and inflammatory edema in the ankle sprain model in rats. Threshold to mechanical stimulation was utilized to examine the changes produced by intraperitoneal injection of non-selective opioid antagonist naloxone on the antihyperalgesic effect induced by a 20-min period of 2Hz or 100Hz TENS in the ankle sprain model, produced by manually overextending the lateral ligaments. Ankle sprain induced a long-lasting reduction in paw withdrawn latency (PWL) after 30 minutes for up to 24 hours in sham TENS (SH-TENS) treated rats. The reduced PWL after the induction of ankle sprain was restored partially at 0,1,2,3 and 6, but not 24 hours, after the termination of 2 Hz-TENS (LF-TENS). In 100Hz (HF-TENS) the reduction in PWL was shorter than LF-TENS and both LF and HF effects were fully blocked in naloxone-treated rats. LF- and HF-TENS treated rats did not reach the elevation of edema and presented a progressive edema reduction for over 24 hours when compared to SH-TENS group. Both effects were reduced by naloxone. TENS-induced antihyperalgesic and anti-edematous effects observed in ankle sprain model were mediated by the endogenous opioid system.
Efeitos da hidroginástica com exercícios dinâmicos em deslocamento sobre o equilíbrio corporal de idosos
Authors: Souza Junior Roberto Otheniel de , Deprá Pedro Paulo , Silveira Alexandre Miyaki da
Published: October 2017

RESUMO A hidroginástica é uma atividade física que pode ajudar os idosos na prevenção de perdas funcionais como o equilíbrio postural. O objetivo deste estudo foi investigar os efeitos de um programa de hidroginástica com ênfase em exercícios dinâmicos em deslocamento sobre o equilíbrio corporal de idosos. A amostra foi dividida em dois grupos: grupo experimental (GE) (n=27, idade=67,33±5,53 anos) e grupo controle (GC) (n=10, idade=67,74±7,24 anos). O GE participou de duas aulas semanais de hidroginástica com duração de cinquenta minutos, durante dezesseis semanas. O equilíbrio postural foi mensurado pelo comportamento do Centro de Pressão (COP) utilizando uma plataforma de força. Observou-se nos resultados melhor desempenho no deslocamento total e na amplitude ântero-posterior do GE comparado ao GC. Também após o período de intervenção o GC apresentou significativo aumento da área do COP. Concluiu-se que a prática da hidroginástica, enfatizando exercícios com diferentes formas de deslocamentos, pode alterar significativamente os índices de equilíbrio postural.
Analysis of pain, functional capacity, muscular strength and balance in young women with Patellofemoral Pain Syndrome
Authors: Zamboti Camile Ludovico , Silva Junior Rubens Alexandre da , Gobbi Cynthia , Shigaki Leonardo , Macedo Christiane de Souza Guerino
Published: October 2017

Abstract Introduction: Patellofemoral Pain Syndrome (PFPS) is associated with anterior knee pain, changes in functional capacity, balance and muscle strength disorders. Objective: To quantify pain, functional capacity, strength in quadriceps (Q), gluteus medium (GM), hip external rotator (ER) muscles and balance in sedentary women with PFPS. Methods: Twenty sedentary women, aged 18 to 25 years, were divided into two groups: PFPS (N=10) and control group (N=10). All the volunteers answered the items of the Visual Analogue Scale (VAS), the Lysholm Knee Score Scale, the Anterior Knee Pain Scale (AKPS), and the Lower Extremity Functional Scale (LEFS). The participants performed the following tests: maximal voluntary isometric contraction measured by dynamometry; postural balance using the Star Excursion Balance Test (SEBT) and a force platform. Statistical analyses were performed using the Shapiro Wilk test, the Mann Whitney U test and Spearman’s correlation coefficient. Data were submitted to SPSS 20 software. Results: The PFPS group presented greater pain, balance impairment and higher average velocity of oscillation; however, no differences were observed in Q, GM and RE muscle strength and in balance analyzed by SEBT. Conclusion: Women with PFPS exhibited greater pain, worse functional capacity and body balance. Moderate correlation between both balance tests suggests the use of SEBT when the force platform is not available, which could facilitate and highlight the importance of clinical diagnosis with regard to postural balance.
Therapeutic ultrasound associated with copaiba oil reduces pain and improves range of motion in patients with knee osteoarthritis
Authors: Sousa Filho Luis Fernando , Souza Jessica Batista de , Almeida Grace Kelly Melo de , Jesus Itamar Couto Guedes de , Oliveira Evaleide Diniz de
Published: October 2017

Abstract Introduction: Osteoarthritis is a disease that affects millions of Brazilians.Therapeutic ultrasound has been used in its treatment, either alone or associated with drugs. Objective: The aim of this study was to evaluate the effects of ultrasound (US) associated with Copaiba oil (CO) on knee osteoarthritis. Methods: Patients were divided into three different groups: US, US+CO, CO.Ten treatment sessions were held twice a week, 30 minutes each.Pain intensity was assessed through the Visual Analog Scale (VAS) and Range of Motion (ROM) by goniometry, and muscle strength was assessed by means of the Medical Research Council Scale. Statistical analysis was performed by Cohen’s d test, student’s t test and ANOVA, considering p<0.05 as significant. Results: Pain reduced in all groups.The US+CO group (d = -3.50) presented larger effect size when compared to the other groups. Regarding ROM, the largest effect size was observed in the US+CO group for flexion (d = 0.86) and extension (d = 0.97) in comparison with the remainder groups. Muscle strength increased in the US (d = 1.54) and US+CO (d = 1.60) groups for flexion.Regarding extension, the US group presented the largest effect size (d = 1.80). Conclusion: Therapeutic ultrasound associated with copaiba oil is a practical and effective therapy for the treatment of inflammatory diseases such as osteoarthritis.
Spastic diparetic does not directly affect the capacity to ascend and descend access ramps: three-dimensional analysis
Authors: Mélo Tainá Ribas , Guimarães Ana Tereza Bittencourt , Israel Vera Lúcia
Published: October 2017

Abstract Introduction: Diplegic children have difficulties in gait and therefore ramps are used as strategies of accessibility. Objective: The present study investigated the influence of an inclined surface (ascending and descending) on the kinematic characteristics during gait of the diplegic group (DG) when compared to typically developing children of the control group (CG). Methods: Study participants included 20 children (10 with DG and 10 CG) matched by age, which were evaluated in three experimental conditions (horizontal and inclined ascending and inclined descending surfaces of 7º) through an optoelectronic imaging system. Results: Among the linear kinematic variables, only step width differed among groups, however, without influence of the surface. The foot height differed among the groups only in the descending phase, where DG had greater difficulty in raising the foot. The 3-dimensional gait analyses could not provide more evidences of differences in kinematics variables, especially in transverse plane, between DG and CG, but provide some evidence to support that hip range of motion (ROM) during the gait cycle, hip flexion-extension in initial contact, knee ROM and the 2nd anterior-posterior trunk peak amplitude of the DG were influenced on descent by their flexor pattern. Conclusion: The DG was most affected by the inclination plane than CG especially on descent. Although a hip and knee flexor pattern is evident for DG on inclination of 7º, this angle is accessible since it allows independent gait functional activity.
Phisical modalities on the functional performance in knee osteoarthritis: a sytematic review
Authors: Ferronato Letícia , Cunha Hemily Marega , Machado Pâmela Maiara , Souza Gabriela dos Santos de , Limana Mirieli Denardi , Avelar Núbia Carelli Pereira de
Published: October 2017

Abstract Introduction: Despite recent advances in the treatment of osteoarthritis (OA), few studies have evaluated the longitudinal effect of physical modalities in functional capacity in patients with knee OA. Thereby, since the physical components and pain can affect the functional performance of daily activities, the effect of these treatment’s form is still to be established. Objective: Evaluate the effectiveness of therapeutic ultrasound, electrical stimulation and phototherapy in the functional performance, in patients with knee osteoarthritis. Methods: Articles present in the PubMed, Lilacs, SciELO and PEDro’s databases were evaluated. The used keywords were “pulsed ultrasound therapy”, “ultrasound therapy”, “electric stimulation” and “low level laser therapy” in combination with “knee osteoarthritis”. Were included in this presented review, randomized clinical studies using ultrasound, electrical and laser stimulation in subjects with knee osteoarthritis. To evaluate the methodological quality of the selected studies, was used the PEDro’s scale. The dependent variables of the study were: pain, physical function, joint stiffness, life quality and functional performance. Results: 268 studies were found, of these, 41 studies met eligibility criteria and were classified for analysis in full. The used methodology in the studies varied widely, however, in most cases there was improvement in functional performance of individuals with knee OA, with the use of physical modalities, for the pulsed ultrasound, continuous ultrasound, electrical stimulation and laser resourses. Conclusion: The physical modalities used in the studies demonstrated improvement in functional performance of individuals with knee OA.
Temporomandibular joint dysfunction in Parkinson's Disease: an integrative literature review
Authors: Silva Taysa Vannoska de Almeida , Coriolano Maria das Graças Wanderley de Sales , Lins Carla Cabral dos Santos Accioly
Published: October 2017

ABSTRACT Temporomandibular joint dysfunction is a set of disorders involving the masticatory muscles, temporomandibular joint and associated structures. It is known that the progression of motor symptoms in Parkinson's disease is an indication that these people are more prone to the development of this dysfunction. Thus, this study aims to investigate the signs and symptoms of temporomandibular dysfunction in people with Parkinson's disease. The search was performed in the databases: MEDLINE/ PubMed, LILACs, CINAHL, SCOPUS, Web of Science and PEDro, without timing or language restriction. Specific descriptors were used for each database and keywords, evaluated by the instruments: Critical Appraisal Skill Program and Agency for Health care and Research and Quality. A total of 4,209 articles were found but only 5 were included. After critical analysis of the methodology of the articles, one did not reach the minimum score required by the evaluation instruments, thus, it was excluded. The selected articles addressed, as signs and symptoms of temporomandibular joint dysfunction, the following: myofascial pain, bruxism, limitation of mouth opening, dislocation of the articular disc and asymmetry in the distribution of occlusal contacts. Further studies are needed in order to determine the relationship between cause and effect of the analyzed variables, so as to contribute to more specific and effective therapeutic interventions.
Adults writing profile at the beginning of their reading and writing acquisition
Authors: Paula Jéssica Rodrigues de , Oliveira Ariadnes Nobrega de , Costa Amanda Luiza Aceituno da , Crenitte Patrícia Abreu Pinheiro , Costa Aline Roberta Aceituno da
Published: October 2017

ABSTRACT Purpose: to describe and analyze the writing profile of 12 adults in the literacy phase. Methods: 12 students of both genders enrolled in the Youth and Adult Education Program (EJA) of public school in a medium-sized city in the state of São Paulo. The study was divided into two stages: proposal presentation to participants and School Performance Test assessment to evaluate the writing phase and the type of error presented by each participant. Results: the majority of the results belonged to the alphabetical phase (criterion established by Ferreiro and Teberosky). The most frequent errors were grapheme omissions and oral support. Conclusion: results indicated the need to focus on the alphabetic principle acquisition, which allows the initial writing by the phonological route, and to work the differences between standard and colloquial language.
Dysarthria and quality of life in patients with amyotrophic lateral sclerosis
Authors: Leite Neto Lavoisier , Constantini Ana Carolina
Published: October 2017

ABSTRACT Purpose: to analyze the impact of dysarthria on the quality of life in patients with amyotrophic lateral sclerosis. Methods: the study consisted of 32 subjects, divided into two groups (control group and study group) who underwent an initial interview for background information, followed by an evaluation based on the Dysarthria Assessment Protocol and completion of quality of life questionnaire "Living with Dysarthria - (LwD)". Exploratory data analysis was collected through mean, median, SD, minimum and maximum measures. A comparison was performed between the studied groups and a correlation was carried out between scores. The significance level adopted was 5%. Results: according to the findings, all sub-items analyzed by the dysarthria assessment protocol were statically significant (p <0.001) when comparing the groups. Regarding quality of life, a moderate positive correlation (p = 0.0008; Spearman's coefficient = 0.75202) was observed between the total score of the two protocols used, indicating that the higher the degree of dysarthria, the worse the Quality of Life (QOL) of the subject, according to the parameters evaluated. Conclusion: dysarthria affects all speech parameters herein assessed, in varying degrees, negatively impacting communication and quality of life.
Quality of life after orthognathic surgery: a case report
Authors: Torres Katarina Vilar , Pessoa Luciane Spinelli , Luna Anibal Henrique Barbosa , Alves Giorvan Ânderson dos Santos
Published: October 2017

ABSTRACT This case study aims to describe the effects of orthognathic surgery on the quality of life of a patient with class III dentofacial deformity. The protocols Oral Health Impact Profile, short version, and Orthognathic Quality of life Questionnaire were applied before and after orthognathic surgery to measure the quality of life of a subject. The data were collected from a clinical case report. We observed that, by the Oral Health Impact Profile, the quality of life was not affected by dentofacial deformity (score = 1), and that there was a 30-day postoperative score increase (score = 9), indicating a worsening of quality of life and an improvement after 90 days (score = 4). On the other hand, by the Orthognathic Quality of life Questionnaire, it was noticed that dentofacial deformity negatively affected the patient's quality of life (score = 34), and that there was a progressive improvement in scores after surgery, i.e., from score 15 to 2, showing a positive impact on quality of life. The orthognathic surgery positively influenced the patient's quality of life, requiring the application of specific protocols that accurately measure the impacts of the procedure on the individual's life.
El trabajo social en los aparatos del Estado y su posicionamiento ético-político en la garantía de los derechos sociales
Authors: Estalayo Maribel Martín , Sáez Luis Nogués
Published: October 2017

Resumen Este artículo tiene como objetivo analizar relatos de un grupo de profesionales de trabajo social en España que, bajo la pretensión de recuperar la esencia del trabajo social y con el malestar que comporta ejercer la tarea en un contexto de remercantilización y privatización de lo social, difuminan el compromiso profesional. Dichos relatos, supuestamente, se vacían ideológicamente alejándose de prácticas comprometidas con la igualdad social y la garantía de derechos sociales, conformando un pensamiento único. Plantear la importancia de que la relación profesional se teja en torno a la defensa de los derechos sociales y a la dotación de recursos y prestaciones económicas, es resistir a las visiones esencialistas del trabajo social; es superar los discursos que sitúan de modo antagónico una intervención basada en la racionalidad o en la emocionalidad; en lo objetivo o en lo subjetivo; en la ayuda material o en el apoyo psicosocial; en la burocracia o en la adhocracia. Resulta estratégico que las/los trabajadoras/es sociales del sistema público de servicios sociales adopten una actitud ética y política que contribuya a regenerar la parte social del Estado.
Herança familiar na política: retrato dos limites da democracia no Brasil contemporâneo
Authors: Nobre Maria Cristina de Queiroz
Published: October 2017

Resumo O artigo traz reflexão teórica sobre a herança familiar na política influindo nos resultados eleitorais ainda hoje, resultado de simbiose que envolve cultura do favor, marketing político e poder econômico. Condição que sugere atualização de nossas raízes coloniais patrimonialistas e registro do inconcluso processo de modernização burguesa. O objetivo da reflexão é contribuir com pistas para se compreender a crise institucional e política que provocou a perda do mandato presidencial de Dilma Rousseff em 2016 através de golpe parlamentar, midiático e jurídico. A análise pauta-se em estudo bibliográfico no contexto de pesquisa particular sobre clãs políticos familiares do Ceará. Ao considerar outros estudos sobre o Brasil, pôde-se constatar a abrangência da influência familiar em diferentes esferas do poder político. Nesses termos, conclui-se sobre a frágil democracia brasileira que é acentuada por novo ciclo neoliberal e perspectivas de perdas de direitos sociais e trabalhistas.
Host-seeking behavior of the Heterorhabditis amazonensis nematode in response to stimulant sources1
Authors: Andaló Vanessa , Moreira Grazielle Furtado , Moino Junior Alcides
Published: October 2017

ABSTRACT Several species of entomopathogenic nematodes have different host-seeking methods, and could be considered as "ambusher" or "cruiser". These differences may depend on how the nematodes detect the volatile signals used as cues for foraging. This study aimed to evaluate the locomotor response of Heterorhabditis amazonensis RSC5 to the compounds from root exudates of different plants, as well as to stimulants produced by the presence of insects or to the feeding activity of insects on plants. Arenas with agar-water substrates, containing root exudates from corn, bean, soybean, cucumber, garlic and tomato seedlings, were assembled to determine the substrates possibly preferred by H. amazonensis.Arenas with sand were also constructed to include, besides the seedling root exudates, treatments containing Spodoptera frugiperda, garlic seedlings and S. frugiperda feeding on garlic seedlings. The H. amazonensis species was attracted to the volatile chemicals emitted by all the root exudates tested, especially the exudate from garlic seedlings. However, it showed the greatest attraction to the combination of garlic seedlings and S. frugiperda, indicating that the search of H. amazonensis for its host is enhanced by the association between the insect and the volatile chemical compounds produced by plants, when attacked by insects.
Priming effect on the physiological potential of maize seeds under abiotic stress1
Authors: Gouveia Geraldo Candido Cabral , Binotti Flávio Ferreira da Silva , Costa Edilson
Published: October 2017

ABSTRACT Abiotic stress directly influences seed performance, so poor-vigor seeds under adverse conditions tend to show lower germination speed and rate. By controlling the hydration level of seeds (i.e., priming) with the addition of chemical agents, it is possible to elicit the maximum physiological potential of seeds, even under stress conditions. This study aimed to evaluate the priming effect of different chemical agents on the physiological potential of maize seeds under abiotic stress (polyethylene glycol induced water stress, hypoxia, low temperature and salt stress after controlled deterioration). The experimental design was completely randomized, in a 5 x 2 factorial scheme, consisting of different chemical agents used to hydrate the seeds [control without priming; control primed with water; calcium nitrate (0.2 %); amino acid L-phenylalanine (0.05 %); amino acid L-phenylalanine (0.5 %) + calcium nitrate (0.2 %)] and 2 seed lots, with four replicates. Priming with calcium nitrate lead to a greater germination and higher emergence rate of the seedlings under suboptimal temperature conditions, and seeds that underwent controlled deterioration showed greater germination levels with the use of calcium nitrate + phenylalanine in the priming process, regardless of the lot used. In general, seed priming allowed a greater expression of seed vigor, even though an interaction with lots was observed in some variables.
Work-home boundary limits: a study of evangelical pastors’ daily lives
Authors: Guidi Antônio Carlos , Vasconcelos César Ricardo Maia de
Published: October 2017

Abstract The aim of this research is to analyse the mutual influence in the process of negotiating work-home boundaries and personal and social identity or, in other words, to study the method of adapting and managing domestic and professional conflicts which interfere with the harmony of evangelical pastors’ work and personal lives. We conducted a qualitative study in order to achieve the proposed aims, involving an interpretative approach with the pastors of a specific ecclesiastical institution: The Assemblies of God in Brazil. A total of 20 interviews were held, and, following coding procedures, boundary-work tactics, whose taxonomy falls within physical, behavioural, temporal and communicative dimensions, were found. The results revealed that the sharp distinction seen was that the subjects were more likely to mingle interactions in work-home boundaries. The boundary-negotiation tactics were shown to be multi-functional, as they have dual function techniques, used both to segment and integrate the work-home boundary.
Apresentação de um Protocolo Assistencial para Pacientes com Distúrbios da Deglutição
Authors: Borges Mariana de Sousa Dutra , Mangilli Laura Davison , Ferreira Michelli Cristina , Celeste Letícia Correa
Published: October 2017

RESUMO Objetivo Descrever o processo de implantação de Protocolo Assistencial para os Distúrbios da Deglutição em unidade hospitalar pública de alta densidade tecnológica no Distrito Federal. Método Trata-se de um estudo descritivo do tipo Relato de Experiência com descrição do processo de implantação de Protocolo Assistencial para os Distúrbios da Deglutição em unidade hospitalar pública de alta densidade tecnológica no Distrito Federal. Resultados A implantação do Protocolo consistiu em três etapas de trabalho: Etapa 1 - busca na literatura sobre os procedimentos que caracterizariam as melhores práticas propedêuticas e terapêuticas; Etapa 2 - discussão com equipe multidisciplinar para ajustes necessários à execução da proposta de implantação de um Protocolo Assistencial para os Distúrbios da Deglutição; e Etapa 3 - proposta final do Protocolo Assistencial para os Distúrbios da Deglutição considerando as particularidades do serviço. Conclusão A proposta final do Protocolo Assistencial para os Distúrbios da Deglutição (PADD) apresenta um método sistematizado pré-definido para acompanhar os pacientes com alteração da deglutição de unidades de saúde de alta densidade tecnológica. O PADD propõe-se a favorecer a detecção precoce do distúrbio, a tomada de decisões terapêuticas uniformes, a utilização de métodos propedêuticos e terapêuticos de baixo custo e a auxiliar gestores no processo de avaliar a qualidade do serviço ofertado através da mensuração de indicadores.
Avaliação da atenção primária em saúde por usuários com e sem deficiência
Authors: Almeida Maria Helena Morgani de , Pacheco Samanta , Krebs Stephanie , Oliveira Amanda Manso , Samelli Alessandra , Molini-Avejonas Daniela Regina , Toldrá Rosé Colom , Oliver Fátima Corrêa
Published: October 2017

RESUMO Objetivo Avaliar atributos essenciais (acesso de primeiro contato, longitudinalidade, integralidade e coordenação da atenção) e derivados (orientação familiar e comunitária) da Atenção Primária em Saúde (APS) na percepção de usuários com e sem deficiência. Método Estudo transversal observacional utilizando o questionário Primary Care Assesment Tool em usuários autodeclarados com e sem deficiência de cinco unidades básicas de saúde de um município no qual 55% da população depende do SUS. Foram atribuídos escores para as respostas dadas a cada atributo de atenção primária à saúde avaliado. Resultados Participaram 93 usuários (67 com e 26 sem deficiência). Não houve diferença estatisticamente significante para nenhum dos atributos na comparação entre pessoas com e sem deficiência. Para o grupo como um todo, obtiveram-se escores acima do critério de corte: Grau de afiliação, Acesso de primeiro contato (utilização), Longitudinalidade e Coordenação da atenção (sistema de informação). Receberam pior avaliação: Acesso de primeiro contato (acessibilidade), Coordenação da atenção (integralidade do cuidado), Integralidade (serviços disponíveis e prestados) e Orientação familiar e comunitária. Os usuários reconhecem que as equipes identificam problemas de locomoção e movimentação, mas que existem falhas no reconhecimento de problemas para ouvir, falar e enxergar; e na orientação das pessoas que necessitam de auxílio e das que prestam cuidados. Conclusão Os usuários com e sem deficiência avaliaram de forma semelhante a atenção que recebem e indicaram fragilidades no reconhecimento de demandas específicas. Há necessidade de mudanças (estruturais e do processo de trabalho) para assegurar acessibilidade, integralidade do cuidado e orientação familiar e comunitária e, assim, melhor qualificar a APS.
Fruit color and post-harvest shelf life in tomato affected by the ogc, nor A, and rin alleles
Authors: Poma Betsabé Antezana , Maluf Wilson Roberto , Gouveia Beatriz Tome , Oliveira Alisson Marcel Souza de , Ferreira Rodolfo de Paula Duarte , Carvalho Regis de Castro
Published: October 2017

Abstract: The objective of this work was to evaluate the effects of the mutant alleles alcobaça (nor A ), ripening inhibitor (rin), and old gold crimson (og c ), in heterozygosity or homozygosity, on the expression of color and on the postharvest quality of fruit of experimental tomato hybrids. Fourteen hybrids with contrasting genotypic constitutions in the nor A , rin, and og c loci were evaluated in a randomized complete block design with four replicates. The following fruit postharvest quality traits were evaluated: firmness in the breaker stage, color, and soluble solids content. The rin +/rin and nor +/nor A genotypes increased firmness of tomato fruit at harvest (breaker stage). The rin + /rin genotypes displayed the worse internal fruit color. There was a positive effect of og c+ /og c in improving the internal color of rin + /rin and nor + /nor A fruit, making the color similar to that of the normal genotypes. The combination of the og c /og c rin + /rin nor + /nor A genes is effective to improve tomato fruit firmness, besides maintaining or improving internal color.
Interventions of the clinical pharmacist in an Intermediate Care Unit for elderly patients
Authors: Viana Stéphanie de Souza Costa , Arantes Tiago , Ribeiro Sabrina Corrêa da Costa
Published: October 2017

ABSTRACT Objective To discuss the role of the clinical pharmacist in hospital care of critical elderly patients. Methods Critical patients aged 60 years and over admitted by the clinical staff to an Intermediate Care Unit were followed-up for 4 months regarding their drug therapies. Medical prescriptions were reviewed daily on the basis of patients’ clinical conditions, with the view to identify opportunities for optimization of drug therapies, contributing to safer prescribing, reduced discomfort and correct and rational use of drugs. Results A total of 386 prescriptions were reviewed and 212 pharmaceutical interventions performed; 64.3% of prescriptions were classified as accepted with changes, 28.5% not accepted and 7.2% verbally accepted with no changes. Interventions included drug therapy indications, directions for dose adjustment, reduction of the use of potentially inappropriate medications for older patients, prescription adjustments, discontinuing unnecessary drugs, among others. Conclusion The significant number of interventions accepted by the healthcare staff supports the relevance of the clinical pharmacist as a member of the multiprofessional team, especially in care of the elderly.
Low-level laser irradiation promotes proliferation of cryopreserved adipose-derived stem cells
Authors: Ginani Fernanda , Soares Diego Moura , Rocha Hugo Alexandre de Oliveira , Barboza Carlos Augusto Galvão
Published: October 2017

ABSTRACT Objective To evaluate the effect of low-level laser irradiation on proliferation and viability of murine adipose-derived stem cells previously submitted to cryopreservation. Methods Adipose-derived stem cells were isolated from inguinal fat pads of three mice, submitted to cryopreservation in fetal bovine serum with 10% dimethylsulfoxide for 30 days and then thawed and maintained in normal culture conditions. Culture cells were either irradiated or not (control) with an InGaAIP diode laser at zero and 48 hours, using two different energy densities (0.5 and 1.0J/cm2). Cell proliferation was evaluated by trypan blue exclusion method and MTT assay at intervals of zero, 24, 48, and 72 hours after the first laser application. Cell viability and apoptosis of previously cryopreserved cells submitted to laser therapy were evaluated by flow cytometry. Results The Irradiated Groups (0.5 and 1.0J/cm2) showed an increased cell proliferation (p<0.05) when compared to the Control Group, however no significant difference between the two energy densities was observed. Flow cytometry revealed a percentage of viable cells higher than 99% in all groups. Conclusion Low-level laser irradiation has stimulatory effects on the proliferation of adipose-derived stem cells previously submitted to cryopreservation.
Progesterone level on the day of hCG administration in relation to the pregnancy rates of patients undergoing assisted reproduction techniques
Authors: Oliveira Renato de , Cabral Fernanda Godoy , Carvalho Waldemar de Almeida Pereira , Cordts Emerson Barchi , Bianco Bianca , Barbosa Caio Parente
Published: October 2017

ABSTRACT Objective To evaluate the predictive capacity for pregnancy of the progesterone level on the day of administering human chorionic gonadotropin, in women submitted to assisted reproductive techniques. Methods An observational study with 914 women submitted to assisted reproductive techniques from August 2014 to June 2016. Results Total pregnancy rate was 34.58%; in that, the pregnancy rate in women <35 years, between 35 and 38, and >38 years was, respectively, 42.3%, 38.7% and 16.1% (p<0.001). For embryo transfer in the same cycle, and progesterone of 1.3ng/dL, sensitivity was 4.78%, specificity, 84.18%, accuracy, 56.72%, positive likelihood ratio of 0.3019, and negative likelihood ratio of 1.1312, with receiver operating characteristic curve of 0.46 (95%CI: 0.42-0.49). Conclusion The progesterone level on the day of administering human chorionic gonadotropin of 1.3ng/dL differs from that empirically adopted at the study site (1.7ng/dL), and has a better predictive capacity for pregnancy in the patients studied. However, the low sensitivity of this examination raises questions about its real importance.
Gene therapy: advances, challenges and perspectives
Authors: Gonçalves Giulliana Augusta Rangel , Paiva Raquel de Melo Alves
Published: October 2017

ABSTRACT The ability to make site-specific modifications to the human genome has been an objective in medicine since the recognition of the gene as the basic unit of heredity. Thus, gene therapy is understood as the ability of genetic improvement through the correction of altered (mutated) genes or site-specific modifications that target therapeutic treatment. This therapy became possible through the advances of genetics and bioengineering that enabled manipulating vectors for delivery of extrachromosomal material to target cells. One of the main focuses of this technique is the optimization of delivery vehicles (vectors) that are mostly plasmids, nanostructured or viruses. The viruses are more often investigated due to their excellence of invading cells and inserting their genetic material. However, there is great concern regarding exacerbated immune responses and genome manipulation, especially in germ line cells. In vivo studies in in somatic cell showed satisfactory results with approved protocols in clinical trials. These trials have been conducted in the United States, Europe, Australia and China. Recent biotechnological advances, such as induced pluripotent stem cells in patients with liver diseases, chimeric antigen receptor T-cell immunotherapy, and genomic editing by CRISPR/Cas9, are addressed in this review.
Prediction of development length from free-end slip in pretensioned concrete members
Authors: Dang Canh N. , Floyd Royce W. , Hale W. Micah , Martí-Vargas José R.
Published: October 2017

Development length of prestressing strands is a significant parameter in the design of pretensioned concrete members. The adequacy of the code equations used to predict the development length needs to be verified when a new material or design parameter is introduced for precast, prestressed concrete applications. This study develops a simple and reliable technique to quantify the development length based on the premise of the slip theory, which proposes the free-end slip (FES) as an indicator of the development length. Twenty-five pretensioned concrete beams were cast with 15 mm diameter strands. FES was measured at both beam ends at prestress transfer. Development length was determined by performing bending tests at different embedment lengths. The experimental results were synthesised to revise the slip theory. The applicability of the revised-slip theory was validated by collected experimental data of pretensioned concrete members using various types of concrete, strand diameters and release techniques.
IN VIVO INTERACTION OF PROPYLTHIOURACIL WITH SODIUM IODIDE (Na131I) RADIOPHARMACEUTICAL IN RATS (Rattus norvegicus)
Authors: Daruwati Isti , Halimah Iim , Mahendra Isa , Deasy F Dwi , Hanafiah WS A.
Published: October 2017

IN VIVO INTERACTION OF PROPYLTHIOURACIL WITH SODIUM IODIDE (Na131I) RADIOPHARMACEUTICAL IN RATS (Rattus norvegicus).. The aim of this research is to determine the effect of propylthiouracil (PTU) treatment to pharmacokinetics interaction and biodistribution profile of Na131I radiopharmaceuticals. Three groups of animal model were used in this experiment, i.e. experimental animals which given PTU for 1 time (onset or A groups), PTU for six days (B Groups) and without treatment (control or C Groups). Pharmacokinetics and biodistribution test were conducted by giving PTU per oral and  after 24 hours, continued by giving Na131I solution per oral. In pharmacokinetics test, percentage of injection dose/gram of blood (%ID/g) was calculated to determine the absorption, distribution and elimination half time. In biodistribution test, percentage of injection dose/gram of organs was calculated to determine the accumulation of Na131I in spesific organs. The results showed that the absorption half time of A, B and C groups were 3.14 ± 1.42, 2.49 ± 0.49 and 2.52 ± 0.7 hours, respectively. The distribution half time of A, B and C groups were 10.58 + 5.85, 12.92 + 3.75 and 11.42 + 3.15 hours, respectively. The elimination half time of A, B and C groups were 113.03 + 46.03, 96.57+ 47.76 and 196.71 + 145.21 hours, respectively. Biodistribution test results showed that the accumulation of Na131I in thyroid of A, B and C groups were 1.31 + 0.45, 5.03 + 0.55 and 4.45 + 2.24 % respectively. This research was concluded that PTU treatment cannot alter absorption, distribution and elimination half time Na131I, but the accumulation in thyroid was decrease in A group to control.
Enhancing Expectations of Cooperative Learning Use through Initial Teacher Training
Authors: Duran Gisbert David , Corcelles Seuba Mariona , Flores Coll Marta
Published: October 2017

Despite of its relevance and evidence support, Cooperative Learning (CL) is a challenge for all the educational systems because of the difficulties for its implementation. This study has the objective to identify the effect of Primary Education initial teacher training in the prediction of future CL use. Two groups, of 44 and 45 students, were conceptually trained, with the latter also having the opportunity to experience CL in the university classroom. Opting for a mixed methods research, this study tries to identify changes in a pre- and post-test Cooperative Learning Implementation Questionnaire and to explain possible changes through 4 focus groups. Quantitative results show differences in expectations of CL success and index of CL use for the group who had the CL experience. Qualitative data revealed that improvements can be explained by the increase in students’ awareness of the learning opportunities that CL offered them, giving and receiving scaffold help, preparing activities and enhancing motivation.
Young Children about School: Whose Voices Do We Hear?
Authors: Tertoolen Anja , Geldens Jeannette , Van Oers Bert , Popeijus Herman
Published: October 2017

School is one of the important educational practices, in which children are actively involved. When we want to contribute to the development of young children’s voices, we need deeper insight into the way children act as they do. Therefore, we have to distinguish how young children’s voices are composed, as we proclaim that all voices are essentially polyphonic. We found children’s expressions which were not corresponding with their own teachers’ and parents’ expressions. Many of the presented examples of non-corresponding expressions by the children, refer to situations in which resistance, one of the identifiers of voice, is shown. This article is part of a larger study we conducted on young children’s voices. In our research we want to explore the content of young children’s voices and the meaning they attribute to the educational contexts they are involved in. We conducted five case studies with young children, aged 5-6, in school. We have analyzed their expressions and presented our findings earlier. In this phase of our research project we are looking for possible correspondences between the children’s expressions and the expressions of their teachers and parents
America's first century of marine national park stewardship
Authors: Davis Gary E. , Kimball Dan B.
Published: October 2017

A review of coastal national park stewardship reveals a rich history that provides evidence of how nature and human history shaped current conditions along America's coasts. Case studies of Dry Tortugas National Park and Everglades National Park in Florida, and Channel Islands National Park in California exemplify how such experiences can help identify future directions and challenges for protecting coastal areas. Discoveries include (1) ecological and political borders are often incompatible because shorelines are ineffective ecological boundaries, (2) scales of protection are critical for management efficacy, (3) forging effective management solutions requires strategic, innovative public involvement, and (4) misperceptions of connectivity, sustainability, and relevance impair effective coastal conservation. This history and these stewardship experiences also demonstrated the potential power of protected areas to halt shifting ecological and moral baselines, thereby defining realistic imagination and hope for the future. Learning from national park experiences how to understand ecosystems, how to repair damage to their integrity, how to protect and mitigate human stresses to them, and how to better connect people to these special places has not only improved the condition of nature and human heritage in parks, but also has enhanced society's capacity to improve the human condition more broadly with small, but critical success stories.
Understanding and preserving caves and karst landscapes
Authors: Pate Dale L. , Kerbo Ronal C.
Published: October 2017

Beginning in 1903 with the creation of Wind Cave National Park, ten National Park Service units have been created because of the caves they contained. Since the establishment of the National Park Service in 1916, over 5,360 caves are known to exist within at least 99 park units. These caves are found in different types of rocks and were formed by several different mechanisms. The most prolific landscapes that have formed caves are those in soluble rocks such as limestone. Known as karst landscapes, at least 114 park units contain some amount of karst. In the early days, cave parks were developed for their commercial and recreational values. Little was known of the processes that created caves or the many resources that encompassed these entire landscapes. With the help of cave and karst enthusiasts and researchers, and the advent of cave and karst resource managers, the National Park Service has made great strides in understanding these resources. This has led to increased educational opportunities and better management decisions that will enhance long-term preservation of these resources.
Pathophysiological and genetic changes in the body of a pregnant with gestational diabetes
Authors: Akhmetova Elena S.
Published: October 2017

Currently, the reduction of perinatal morbidity and mortality is a key challenge of maternity care in the world. An important role in the structure of perinatal pathology plays a gestational diabetes mellitus (GDM). High incidence of gestational diabetes mellitus (1-14%) and the associated perinatal mortality have not only medical but also social value. The aim of the study was to study the pathophysiological processes that occur in the body of the pregnant woman with GDM and lead to obstetric and perinatal complications, and possible genetic markers that increase execution risks of impaired glucose metabolism in pregnancy at the present stage of scientific development. Materials: literature data of domestic and foreign studies over the period 2006 to 2016. Methods: synthesis of literature data. Conclusion. It is necessary to identify the major genetic predictors of the development of gestational diabetes, with the aim of its prediction and timely prevention of obstetric and perinatal complications.
Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation
Authors: Yakovlev Pavel P.
Published: October 2017

The Aim of the study was to assess modern considerations about the role of aromatase P450 enzyme in female reproductive system and the effect of its activity on the protocols of in vitro fertilization (IVF).

Materials: foreign and Russian literature data from 1978 to 2016.

Methods:review and synthesis of publications has been performed.

Conclusions: Ovarian aromatase is the key steroidogenesis enzyme of the female reproductive system. Its activity depends on many factors, both of intraovarian and extragonadal origin. The ovarian follicular response and oocyte quality in IVF may depend on aromatase activity.
A case of heterotopic pregnancy with selective reduction of the ovum cervical localization and preservation of intrauterine pregnancy
Authors: Romanova Mariya L. , Nesterov Igor M. , Dyachuk Aleksandr V. , Chirskiy Vladislav V.
Published: October 2017

Failure of implantation with the formation of heterotopic pregnancy is, unfortunately, continues to accompany the IVF. This may be due to the inability of the impact on endometrial receptivity. Changing characteristics of endometrial receptivity in conducting IVF determines the probability of formation of this kind of complications. The lack of standards for the conduct of heterotopic uterine and cervical pregnancy include the woman to the group at high risk for bleeding, a subsequent hysterectomy and loss of fertility. Promptly detection of ectopic localization of the ovum by means of methods of ultrasonic diagnostics allows in some cases to carry out organ-sparing surgery. Currently, there is a need for improved approaches to preimplantation training. The article describes a clinical case of heterotopic pregnancy with successful selective reduction of cervical localization of one of the two fertilized eggs and preservation of intrauterine pregnancy.
Talent Management and Innovative Behavior Based on the Mediating Role of Organizational Learning
Authors: Khaki Iman , Erfanian Khanzadeh Hamid , Babaki Rad Azam
Published: October 2017

This study aimed to investigate the relationship between talent management and the innovative behavior of employees based on the mediating role of organizational learning. This study is a descriptive study, according to the data collection and analysis methods and, it is a survey, according to the implementation. It was conducted during 2015 to 2016 in Mashhad, Iran. Participants were 147 staffs employed in the information technology organization of Mashhad municipality. Data were collected using three valid and reliable questionnaires. Data were analyzed using SPSS software version 19. According to the main hypothesis of the study, there is a significant relationship between talent management and the innovative behavior of employees, and organizational learning mediates the relationship between talent management and the innovative behavior of employees. Also, according to the minor hypothesis, there is a significant relationship between the components of talent management and innovative behavior and the components of organizational learning can mediate the relationship between talent management and innovative behavior. Organizational learning capability has a significant relationship with innovation and innovative behavior and the organizational learning is a way in which educational and training opportunities for employees can be linked to innovative goals.
Classification and applying pharmacovigilance principles to study adverse drug reaction and its management
Authors: Pendota Srihitha , Surabhineni Sre Akshaya Kalyani , Katnapally Abhinay Sharma , Porandla Dharanija , Beemreddy Sandeep Kumar
Published: October 2017

Adverse drug reaction (ADR) is an unwanted, undesirable effect of medication resulting in mild to severe effect on the patient. This review explains definitions of ADR and it differentiation with adverse drug event, medication error. ADRs may cause increased length of stay or initial reason for admission and are major cause of morbidity and mortality worldwide. Risk factors for ADR occurrence include age, gender, patients with multiple diseases and multiple drug therapy (polypharmacy). ADRs are classified into different types based on the mechanism and onset of reaction. The causal relation between suspected drug and reaction can be assessed by using causality assessment scales. The severity and preventability of ADR can be assessed by severity assessment scale and preventability scale respectively. Clinical Pharmacists play an important role in monitoring and management of ADRs.