bluuebunny/crossref_metadata_2025 huggingface dataset:
Discontinuation and relapse with paliperidone palmitate three-monthly for maintenance of schizophrenia: Two year follow-up of use in clinical practice
Authors: Wallman Phoebe , Clark Ivana , Taylor David
Published: April 2021

Background:

The use of antipsychotic long-acting injections (LAI) aims to reduce risk of relapse and hospitalisation in patients with schizophrenia compared with oral medication. Paliperidone palmitate is currently the only LAI that can be administered at three-monthly intervals for maintenance treatment of schizophrenia.

Aim:

This prospective study aimed to evaluate relapse and continuation in licensed use of paliperidone palmitate three-monthly (PP3M) over a 2-year follow-up in clinical practice.

Method:

Non-interventional, observational study of patients treated in the South London and The Maudsley NHS Foundation Trust.

Results:

A total of 166 patients initiated on PP3M, 55 were excluded from the study (non-F20 diagnosis ( n = 43); F20 >65 years old ( n = 12)). Of the 111 patients included, 67 (60%) continued PP3M for 2 years. Overall 102 patients received more than one dose of PP3M and 92 (90%) remained on the same dose of PP3M for the whole of their treatment duration. Relapse (defined as a step-up in clinical care) occurred in eight patients (7%) while on PP3M. The most common reason for discontinuation was patient refusal and the most frequent medication prescribed after discontinuation was paliperidone palmitate one-monthly (PP1M). Post hoc, we analysed outcome in those continuing any form of PPLAI (those continuing with PP3M and those switching back to PP1M). Continuation over 2 years with any PPLAI formulation was 73% (81/111) and relapse was recorded in 9% (10/111).

Conclusion:

Overall, PP3M was an effective maintenance treatment for schizophrenia after stabilisation on PP1M in a clinical setting.
Employee Engagement Among Public Employees: Exploring the Role of the (Perceived) External Environment
Authors: Hameduddin Taha
Published: April 2021

While previous public management research has focused on how leadership, managerial behavior, job characteristics, and human resource management policies influence employee attitudes and behavior, we know little about the role of the external environment (both perceived and actual). By comparison, research on the external environment of public organizations has mostly focused on performance, organizational structure, and goal ambiguity. This article connects these two streams of research, develops a theoretical model to examine whether perceived environmental support (PES) influences employee engagement and considers the moderating roles of public opinion, media, and political salience. The findings suggest that PES does matter for the level of employee engagement and that this influence is moderated by political salience. This in turn has implications for how public organizations motivate their employees, manage their external reputations, and navigate their external environments. The paper ends with a discussion of the theoretical and practical implications of the findings and limitations of the study.
Sevoflurane represses the migration and invasion of gastric cancer cells by regulating forkhead box protein 3
Authors: Yong Fangfang , Wang Hemei , Li Chao , Jia Huiqun
Published: April 2021

Objective

Previous studies suggested that sevoflurane exerts anti-proliferative, anti-migratory, and anti-invasive effects on cancer cells. To determine the role of sevoflurane on gastric cancer (GC) progression, we evaluated its effects on the proliferation, migration, and invasion of SGC7901, AGS, and MGC803 GC cells.

Methods

GC cells were exposed to different concentrations of sevoflurane (1.7, 3.4, or 5.1% v/v). Cell viability, migration, and invasion were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and Transwell assays. Immunohistochemical staining and immunoblotting were performed to analyze forkhead box protein 3 (FOXP3) protein expression in tissue specimens and cell lines, respectively.

Results

FOXP3 was downregulated in human GC specimens and cell lines. Functionally, FOXP3 overexpression significantly inhibited the proliferation, migration, and invasion of GC cells and accelerated their apoptosis. Moreover, sevoflurane significantly blocked GC cell migration and invasion compared with the findings in the control group. However, FOXP3 silencing neutralized sevoflurane-induced apoptosis and the inhibition of GC cell migration and invasion. Sevoflurane-induced apoptosis and the suppression of migration and invasion might be associated with FOXP3 overactivation in GC cells.

Conclusions

Sevoflurane activated FOXP3 and prevented GC progression via inhibiting cell migration and invasion in vitro.
Clinical presentation of Rett syndrome in relation to quality of life and family functioning
Authors: Rozensztrauch Anna , Sebzda Agnieszka , Śmigiel Robert
Published: April 2021

Objective

Rett syndrome (RTT) is a chronic condition that manifest in young children, with concomitant comorbidities such as respiratory problems, scoliosis, epilepsy, and malnutrition, which may affect children’s quality of life (QoL) and family functioning. The objective of this cross-sectional descriptive correlation study was to understand the clinical presentation of RTT in relation to QoL and family functioning.

Methods

We included 23 parents of children with RTT. In this study, we used the PedsQL™ Family Impact Module, the Pediatric Quality of Life Inventory 4.0 generic core scales (PedsQL™ 4.0), and an author-designed questionnaire to assess QoL and family functioning.

Results

A significant relationship was observed between PedsQL™ 4.0 score and child’s age in the physical functioning dimension. Children aged 8 to 12 years demonstrated significantly higher scores than those in the other age groups. Malnutrition in the child significantly affected functioning of the family in the family relationships dimension. Children receiving 5 hours of rehabilitation treatment a week had significantly higher QoL in the school functioning dimension.

Conclusions

QOL in children with RTT, as perceived by their parents, is reduced. RTT has a significant negative correlation with family functioning.
Sema3C promotes hepatic metastasis and predicts poor prognosis in gastric adenocarcinoma
Authors: Li Maoran , Xu Danhua , Xia Xiang , Ni Bo , Zhu Chunchao , Zhao Gang , Cao Hui
Published: April 2021

Objective

Semaphorin 3C (Sema3C) may regulate tumor metastasis and prognosis. We determined the biological roles of Sema3C in the hepatic metastasis of gastric adenocarcinoma and evaluated its clinical significance as a potential biomarker.

Methods

Sema3C expression in gastric cancer (GC) cell lines and tissues was measured using RT-qPCR and western blotting. Moreover, Sema3C functions were analyzed using Transwell assays and in vitro metastasis assays in gain- and loss-of-function experiments. Furthermore, the impact of Sema3C on the prognosis of 80 randomly selected patients with GC was investigated by immunohistochemistry. Additionally, the expression of epithelial-mesenchymal transition (EMT) indicators was verified by immunohistochemistry in GC tissues.

Results

Sema3C expression was significantly upregulated in highly metastatic GC cell lines and tissues. Additionally, Sema3C promoted invasion, migration and hepatic metastasis in GC cells. Moreover, Sema3C expression was positively correlated with clinicopathological features in GC and paired hepatic metastatic tissues, and Sema3C expression was an independent prognostic factor. Finally, Sema3C expression was associated with node metastasis, hepatic metastasis and EMT marker expression.

Conclusions

Sema3C may play roles in regulating the EMT and metastasis of gastric adenocarcinoma, highlighting its potential use as a prognostic factor for hepatic metastasis and poor prognosis in gastric adenocarcinoma.
Oesophageal carcinoma with solitary patellar metastasis: a rare case report
Authors: Zhao Yi , Zhang Qianqian , Feng Helin , Zhu Xiyan
Published: April 2021

The incidence of tumours found in the patella, including primary and metastatic tumours, is low. Solitary metastasis of oesophageal carcinoma (OC) in the patella is even rarer. A 50-year-old man presented to our clinic because of pain and limited range of motion in the right knee for 4 hours and after a fall. On the basis of the patient’s medical history, he was diagnosed with OC 2 months previously and underwent two cycles of paclitaxel liposome combined with tiggio chemotherapy (oral tiggio, 40 mg, two times/day, with a treatment cycle of 3 weeks). A 99mTc-methylene diphosphonate bone scintigraphy scan showed increased radioactivity in the right patella. A right knee biopsy showed the presence of patellar metastasis from OC. Unfortunately, the patient denied additional treatment and was discharged for personal reasons. At the 1-month follow-up, which was conducted by a telephone survey, we learned that the patient had died of acute pulmonary embolism. X-rays and computed tomography are useful for diagnosing patellar metastases, but 99mTc-methylene diphosphonate bone scintigraphy can help physicians diagnose patellar metastasis of OC more rapidly. Biopsy with pathology is the gold standard for diagnosing patellar metastases. Additionally, timely surgical treatment prolongs the survival time of these patients.
rs1840680 single nucleotide polymorphism in Pentraxin 3: a potential protective biomarker of severe community-acquired pneumonia
Authors: Zeng Qiaojun , Tang Tiantian , Huang Biru , Bu Shiyi , Xiao Yingqi , Dai Yumeng , Wei Zixin , Huang Linjie , Jiang Shanping
Published: April 2021

Objective

Single nucleotide polymorphisms (SNPs) of pentraxin 3 ( PTX3) are associated with various outcomes of lung infections. This study aimed to analyze the relationship between PTX3 polymorphisms and the severity of community-acquired pneumonia (CAP).

Methods

This is a retrospective case-control study comprising 43 patients with severe CAP (SCAP) and 97 patients with non-severe CAP. Three SNPs in the PTX3 gene (rs2305619, rs3816527, and rs1840680) from peripheral blood samples were genotyped by real-time polymerase chain reaction. The association between each SNP and the CAP severity was analyzed by logistic regression analysis.

Results

We found that the rs1840680 polymorphism was significantly associated with CAP clinical severity. However, no such association was observed for the genotypes and allele frequencies of rs2305619 or rs3816527. The PTX3 rs1840680 AG genotype was an independent factor for a lower risk of SCAP after multivariate logistic regression analysis. Male sex and coronary heart disease were associated with an increased risk of SCAP.

Conclusions

The PTX3 rs1840680 AG genotype was found to be associated with a lower risk of SCAP, and may serve as a potential protective biomarker to help clinical judgment and management.
Clinical application of a multi-groove silicone drain combined with unidirectional negative-pressure drainage system in single-operating-port video-assisted thoracoscopic lung cancer surgery: a comparison study
Authors: Wang Ze , Lv Jian , Zhang Si’ang , Chen Wenjie , Wu Bin , Xue Lei
Published: April 2021

Objective

To evaluate the effect of a new negative-pressure drainage system in thoracoscopic lung cancer surgery; thereby, providing a new option for postoperative drainage.

Methods

We retrospectively analyzed data for 200 patients who underwent thoracoscopic surgery between May 2018 and October 2019. According to the thoracic drainage method, the patients were divided into the thoracic tube group and the new system group. The epidemiological and clinicopathological data were compared before operation, and the clinical effect of thoracic drainage was compared after operation.

Results

There was no significant difference in epidemiological and clinicopathological data between the two groups. There was also no significant difference in drain removal time, hospital stay, and complication rates between the two groups. However, the incidences of pleural effusion and poor incision healing in the new system group were lower than in the thoracic tube group. Visual analog scale (VAS) scores in the new system group were lower than those in the thoracic tube group at each postoperative interval; therefore, the new system group required less analgesia.

Conclusion

The new system was not inferior to thoracic tubes regarding the drainage effect after thoracoscopic lung cancer surgery. Hence, the system is an alternative to traditional thoracic tubes.
Field Density Investigation of Asphalt Mixtures in Minnesota
Authors: Yan Tianhao , Marasteanu Mihai , Bennett Chelsea , Garrity John
Published: April 2021

In a current research effort, University of Minnesota and Minnesota Department of Transportation have been working on designing asphalt mixtures that can be constructed at 5% air voids, similar to the Superpave 5 mix design. High field density of asphalt mixtures is desired because it increases the durability and extends the service life of asphalt pavements. The paper investigates the current situation of field densities in Minnesota, to better understand how much improvement is needed from the current field density level to the desired level, and to identify possible changes to the current mix design to improve field compactability. Field densities and material properties of 15 recently constructed projects in Minnesota are investigated. First, a statistical analysis is performed to study the probability distribution of field densities. Then, a two-way analysis of variance is conducted to check if the nominal maximum aggregate size and traffic levels have any significant effect on field densities. A correlation analysis is then conducted to identify significant correlations between the compactability of mixtures and their material properties. The results show that the field density data approximately obey normal distribution, with an average field density of 93.4% of theoretical maximum specific gravity; there are significant differences in field density between mixtures with different traffic levels; compactability of mixtures is significantly correlated with fine aggregate angularity and fine aggregate gradation of the mixtures.
Exploring the Perth Hamstring Assessment Tool and Lower Extremity Functional Scale in a Proximal Hamstring Avulsion Cohort: A Cross-sectional Study
Authors: Pihl Elsa , Jonsson Kenneth B. , Berglöf Mida , Brodin Nina , Sköldenberg Olof , Hedbeck Carl Johan
Published: April 2021

Background:

The goal of treatment for a proximal hamstring avulsion (PHA) is an objectively restored muscle and a subjectively satisfied, pain-free patient at follow-up. Different self-reported and performance-based outcome measures have been used to evaluate recovery, but their validity is poorly investigated.

Purpose:

To investigate (1) the correlation between the commonly used self-reported outcome measurements, the Perth Hamstring Assessment Tool (PHAT) and the Lower Extremity Functional Scale (LEFS); (2) to what extent these scores can be explained by physical dysfunction as measured by performance-based tests; (3) whether performance-based tests can discriminate between the injured and uninjured extremity; and (4) which activity limitations are perceived by patients several years after the injury.

Study design:

Cohort study (Diagnosis); Level of evidence, 3.

Methods:

We included a consecutive series of patients treated for or diagnosed with PHA in our department between 2007 and 2016 having at least 2 tendons avulsed from the ischial tuberosity. Participants attended 2 study visits, answered questionnaires (PHAT, LEFS, and Patient-Specific Functional Scale [PSFS]), and performed physical performance–based tests (single-leg hop tests, single–step down test, and isometric and isokinetic strength tests).

Results:

A total of 50 patients were included (26 men [52%], 24 women [48%]; mean age, 50.9 years [SD, 9.8 years]). The mean follow-up time was 5.5 years (SD, 2.7 years), and 74% had been surgically treated. The correlation between PHAT and LEFS was strong ( r = 0.832) and statistically significant ( P < .001). Seven of the performance-based tests exhibited a statistically significant but weak correlation with LEFS (0.340-0.488) and 3 of the tests to PHAT (–0.304 to 0.406). However, only peak torque could significantly discriminate between the extremities. The activity limitation most commonly mentioned in PSFS was running (16 patients [32%]).

Conclusion:

Although PHAT and LEFS correlated strongly, the correlations between functional tests and the patient-reported outcome scores were weak, and most functional tests failed to discriminate between the injured and uninjured lower extremity in patients with PHA 5 years after injury. In general, patients alleged few activity limitations, but running difficulty was a common sequela after PHA.
Characterization and projection of dry season municipal solid waste for energy production in Ilorin metropolis, Nigeria
Authors: Ibikunle RA , Titiladunayo IF , Dahunsi SO , Akeju EA , Osueke CO
Published: April 2021

This research investigates the quantity of municipal solid waste produced during the dry season, and its characterization at Eyenkorin dumpsite of Ilorin metropolis, along the Lagos-Ilorin express way. The physicochemical and thermal compositions of the combustible fractions of municipal solid waste were analysed, to ascertain the available calorific value. In this research, the quantity (tonnes) of waste generated, the rate of generation (kg per capita per day), its sustainability and the likely energy and power potentials in the dry season, were essentially predicted. The population responsible for municipal solid waste generation during this study was 1,120,834 people. During the characterization study from November 2018 to February 2019, it was established that 203,831 tonnes of municipal solid waste was produced during the four months of the dry season, at the rate of 1.12 kg per capita per day. It was found that 280 tonnes/day of municipal solid waste with low heating value of 19 MJ kg-1, would generate 1478 MWh of heat energy and 18 MW of electrical energy potentials discretely, and grid of 13 kW.
Environmental impact assessment of organic fraction of municipal solid waste treatment by anaerobic digestion in Sri Lanka
Authors: Weligama Thuppahige Rasangika Thathsaranee , Babel Sandhya
Published: April 2021

The management of organic fraction of municipal solid waste (OFMSW) has continued to be a significant challenge in Sri Lanka. Anaerobic digestion is one of the management options of OFMSW. However, it generates unavoidable environmental impacts that should be addressed. The present study focuses to assess the environmental impact of a full-scale anaerobic digestion plant in Sri Lanka from a life cycle perspective. The inventory data were obtained from direct interviews and field measurements. Environmental burdens were found to be in terms of global warming potential (230 kg CO2 eq) ozone formation on human health (6.15 × 10−6 kg NO x eq), freshwater eutrophication (2.92 × 10−3 kg P eq), freshwater ecotoxicity (9.27 × 10−5 kg 1,4 DCB eq), human carcinogenic toxicity (3.98 × 10−4 kg 1,4 DCB eq), land use (1.32 × 10−4 m2 a crop eq) and water consumption (2.23 × 10−2 m3). The stratospheric ozone depletion, fine particulate matter formation, ozone formation on terrestrial ecosystems, terrestrial acidification, marine eutrophication, ecotoxicity (terrestrial and marine), human non-carcinogenic toxicity, mineral resource scarcity and fossil resource scarcity, were avoided due to electricity production. Results show that the direct gaseous emissions and digestate generation should be addressed in order to reduce the burdens from the anaerobic digestion plant. Finally, the results of the study could help in policy formation and decision-making in selecting future waste management systems in Sri Lanka.
Applying the extended producer responsibility towards plastic waste in Asian developing countries for reducing marine plastic debris
Authors: Johannes Hendro Putra , Kojima Michikazu , Iwasaki Fusanori , Edita Ellen Putri
Published: April 2021

The extended producer responsibility (EPR) has been adopted in many countries throughout the world to give producers responsibility to manage their products until the post-consumer stage. On many occasions in developing countries, the system is mostly implemented for electronic waste. However, with the rising concern on the marine plastic issue, developing countries, including those in Asia, have started to apply EPR for package and container waste. In practice, developing countries show significant differences in their EPR implementation compared with developed ones due to contrasting conditions of several factors, including social, economic and technology. This article aims to explore the challenges of developing countries to apply EPR as well as determine possible measures to overcome the challenges. Results show that applying EPR system for plastic waste in developing countries faces many challenges, such as the existence of a market-based collection system of recyclables, high transportation cost, lack of waste collection services in rural areas, a limited number of facilities to manage certain types of plastic waste, insufficient pollution control and free riding and orphan products. The challenges, furthermore, can be minimised by differentiating the responsibility of producers, focusing on rural and remote areas, involving informal sectors, creating joint facilities in recycling parks, expanding waste management collection services, increasing the use of EPR and minimising free riding.
Which Aspects of the CanMEDS Competencies are Most Valued in Radiologists? Perspectives of Trainees From Other Specialties
Authors: Lee Stefanie Y. , Sharma Namita , Kagoma Yoan K. , Lum P. Andrea
Published: April 2021

Purpose:

Radiologists work primarily in collaboration with other healthcare professionals. As such, these stakeholder perspectives are of value to the development and assessment of educational outcomes during the transition to competency-based medical education. Our aim in this study was to determine which aspects of the Royal College CanMEDS competencies for diagnostic radiology are considered most important by future referring physicians.

Methods:

Institutional ethics approval was obtained. After pilot testing, an anonymous online survey was sent to all residents and clinical fellows at our university. Open-ended questions asked respondents to describe the aspects of radiologist service they felt were most important. Thematic analysis of the free-text responses was performed using a grounded theory approach. The resulting themes were mapped to the 2015 CanMEDS Key Competencies.

Results:

115 completed surveys were received from residents and fellows from essentially all specialties and years of training (out of 928 invited). Major themes were 1) timeliness and accessibility of service, 2) quality of reporting, and 3) acting as a valued team member. The competencies identified as important by resident physicians were largely consistent with the CanMEDS framework, although not all key competencies were covered in the responses.

Conclusions:

This study illustrates how CanMEDS roles and competencies may be exemplified in a concrete and specialty-specific manner from the perspective of key stakeholders. Our survey results provide further insight into specific objectives for teaching and assessing these competencies in radiology residency training, with the ultimate goal of improving patient care through strengthened communication and working relationships.
Emotion information processing as a new component of emotional intelligence: Theoretical framework and empirical evidence
Authors: Fiori Marina , Udayar Shagini , Vesely Maillefer Ashley
Published: April 2021

The relationship between emotional intelligence (EI) and emotion information processing (EIP) has received surprisingly little attention in the literature. The present research addresses these gaps in the literature by introducing a conceptualization of emotional intelligence as composed of two distinct components: (1) EIK or emotion Knowledge component, captured by current ability emotional intelligence tests, related to top-down, higher order reasoning about emotions, and which depends more strongly on acquired and culture-bound knowledge about emotions; (2) EIP or emotion information Processing component, measured with emotion information processing tasks, requires faster processing and is based on bottom-up attention-related responses to emotion information. In Study 1 ( N = 349) we tested the factorial structure of this new EIP component within the nomological network of intelligence and current ability emotional intelligence. In Study 2 ( N =111) we tested the incremental validity of EIP in predicting both overall performance and the charisma of a presenter while presenting in a stressful situation. Results support the importance of acknowledging the role of emotion information processing in the emotional intelligence literature and point to the utility of introducing a new EI measure that would capture stable individual differences in how individuals process emotion information.
Seeing Isn’t Always Believing: Gender, Academic STEM, and Women Scientists’ Perceptions of Career Opportunities
Authors: Bird Sharon R. , Rhoton Laura A.
Published: April 2021

Studies about women’s underrepresentation in the U.S. science, technology, engineering, and mathematics (STEM) academic workforce have flourished in the past decade. Much of this research focuses on institutionalized gender barriers and implicit biases, consistent with theorizing about how work organizations disproportionately benefit men, white people, and other systemically advantaged groups. But to what extent do faculty most likely disadvantaged by systematic inequities actually perceive “barriers” to equity in the context of their own work lives? What might the repercussions associated with variation in perceptions about inequity be, especially within institutions of higher education actively pursuing equity agendas under such programs as the National Science Foundation’s ADVANCE program? Using interview data from 53 STEM women faculty working at a university that received a 5-year NSF ADVANCE IT award, we examine the range of views held among women scientists about the extent to which opportunity and success are a function of meritocratic versus nonmeritocratic processes. Findings show that almost a third of participants held the view that opportunities and advancement are primarily a function of meritocratic processes. We discuss implications of these findings for broader institutional efforts to reduce inequities in academic STEM.
The effect of entrepreneurship education on nascent entrepreneurship
Authors: Onjewu Adah-Kole Emmanuel , Haddoud Mohamed Yacine , Nowiński Witold
Published: April 2021

The literature has been enriched by studies examining the effect of entrepreneurship education on entrepreneurial or goal intention. Yet, few articles have considered how entrepreneurship education affects nascent entrepreneurship as a more sought-after outcome. Similarly, some scholars assess entrepreneurship education as an aggregate rather than a multidimensional construct comprised of alternative methods with peculiar characteristics yielding distinct student outcomes. Possibly, the present shortage of specificity in the investigation of methods in entrepreneurship education reduces empirical understanding of efficacious teaching and learning modes for optimising entrepreneurial behaviour. Hence, by way of contribution, this inquiry isolates and measures the direct effect of courses, workshops, guest speakers and simulations on new venture creation among UK students. It also measures indirect influence in the same relationships, with self-efficacy as a mediator. A structural equation analysis is performed and the findings show that discretely, in this order, simulations, workshops and courses stimulate nascent entrepreneurship. However, there is particular insignificance in the direct link between guest speakers and nascent entrepreneurship, and further dissociation in the indirect link between workshops and simulations leading to self-efficacy. Theoretical implications arise for future correlation and configurational studies, as well as practical ramifications for entrepreneurship education practitioners, simulation developers and public institutions.
Encoding Context Determines Risky Choice
Authors: Madan Christopher R. , Spetch Marcia L. , Machado Fernanda M. D. S. , Mason Alice , Ludvig Elliot A.
Published: April 2021

Both memory and choice are influenced by context: Memory is enhanced when encoding and retrieval contexts match, and choice is swayed by available options. Here, we assessed how context influences risky choice in an experience-based task in two main experiments (119 and 98 participants retained, respectively) and two additional experiments reported in the Supplemental Material available online (152 and 106 participants retained, respectively). Within a single session, we created two separate contexts by presenting blocks of trials in distinct backgrounds. Risky choices were context dependent; given the same choice, people chose differently depending on other outcomes experienced in that context. Choices reflected an overweighting of the most extreme outcomes within each local context rather than the global context of all outcomes. When tested in the nontrained context, people chose according to the context at encoding and not retrieval. In subsequent memory tests, people displayed biases specific to distinct contexts: Extreme outcomes from each context were more accessible and judged as more frequent. These results pose a challenge for theories of choice that rely on retrieval as guiding choice.
Mollusc successions reveal northward postglacial shifts of Alpine species ranges (Bohemian Massif, Czech Republic)
Authors: Juřičková Lucie , Menšík Jakub , Horáčková Jitka , Ložek Vojen
Published: April 2021

The Alps are an important hotspot of species diversity and endemism, as well as a presumed glacial refugium of several species’ groups including land snails. The recent ranges of Alpine endemics are well known, but their fluctuations during the postglacial period mirroring local climate changes are understudied. By analysing five Late Glacial and Holocene mollusc successions from two areas in the southernmost part of the Bohemian Massif (Czech Republic) situated about 100 km north of the Alps, we reveal details of these fluctuations. The Alpine endemic rocky dweller Chilostoma achates had reached the southern part of the Bohemian Massif already in the Late Glacial and disappeared in the Mid-Holocene canopy forest optimum. On the contrary, the northern boundaries of Alpine canopy forest epigeic snails extended further north than today at the turn of the Middle and Late-Holocene, pointing to a more favourable forest microclimate. The earliest known occurrences of several temperate canopy forest central European species, especially Causa holosericea and Discus perspectivus, imply the role of different areas in the Alps as their glacial refugia.
Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism
Authors: Rahi S , Gupta R , Sharma A , Mehan S
Published: April 2021

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disease characterized by cognitive and sensorimotor impairment. Numerous research findings have consistently shown that alteration of Smo-Shh (smoothened-sonic hedgehog) signaling during the developmental process plays a significant role in ASD and triggers neuronal changes by promoting neuroinflammation and apoptotic markers. Purmorphamine (PUR), a small purine-derived agonist of the Smo-Shh pathway, shows resistance to hippocampal neuronal cell oxidation and decreases neuronal cell death. The goal of this study was to investigate the neuroprotective potential of PUR in brain intoxication induced by intracerebroventricular-propionic acid (ICV-PPA) in rats, with a focus on its effect on Smo-Shh regulation in the brain of rats. In addition, we analyze the impact of PUR on myelin basic protein (MBP) and apoptotic markers such as Caspase-3, Bax (pro-apoptotic), and Bcl-2 (anti-apoptotic) in rat brain homogenates. Chronic ICV-PPA infusion was administered consecutively for 11 days to induce autism in rats. In order to investigate behavioral alterations, rats were tested for spatial learning in the Morris Water Maze (MWM), locomotive alterations using actophotometer, and beam crossing task, while Forced Swimming Test (FST) for depressive behavior. PUR treatment with 5 mg/kg and 10 mg/kg (i.p.) was administered from day 12 to 44. Besides cellular, molecular and neuroinflammatory analyses, neurotransmitter levels and oxidative markers have also been studied in brain homogenates. The results of this study have shown that PUR increases the level of Smo-Shh and restores the neurochemical levels, and potentially prevents morphological changes, including demyelination.
Post-Hoc Analysis of a Randomized, Double Blind, Prospective Study at the University of Chicago: Additional Standardizations of Trial Protocol are Needed to Evaluate the Effect of a CXCR1/2 Inhibitor in Islet Allotransplantation
Authors: Bachul Piotr J. , Golab Karolina , Basto Lindsay , Zangan Steven , Pyda Jordan S. , Perez-Gutierrez Angelica , Borek Peter , Wang Ling-Jia , Tibudan Martin , Tran Dong-Kha , Anteby Roi , Generette Gabriela S. , Chrzanowski Jędrzej , Fendler Wojciech , Perea Laurencia , Jayant Kumar , Lucander Aaron , Thomas Celeste , Philipson Louis , Millis J. Michael , Fung John , Witkowski Piotr
Published: April 2021

A recent randomized, multicenter trial did not show benefit of a CXCR1/2 receptor inhibitor (Reparixin) when analysis included marginal islet mass (>3,000 IEQ/kg) for allotransplantation and when immunosuppression regimens were not standardized among participating centers. We present a post-hoc analysis of trial patients from our center at the University of Chicago who received an islet mass of over 5,000 IEQ/kg and a standardized immunosuppression regimen of anti-thymocyte globulin (ATG) for induction. Twelve islet allotransplantation (ITx) recipients were randomized (2:1) to receive Reparixin ( N = 8) or placebo ( N = 4) in accordance with the multicenter trial protocol. Pancreas and donor characteristics did not differ between Reparixin and placebo groups. Five (62.5%) patients who received Reparixin, compared to none in the placebo group, achieved insulin independence after only one islet infusion and remained insulin-free for over 2 years ( P = 0.08). Following the first ITx with ATG induction, distinct cytokine, chemokine, and miR-375 release profiles were observed for both the Reparixin and placebo groups. After excluding procedures with complications, islet engraftment on post-operative day 75 after a single transplant was higher in the Reparixin group ( n = 7) than in the placebo ( n = 3) group ( P = 0.03) when islet graft function was measured by the ratio of the area under the curve (AUC) for c-peptide to glucose in mixed meal tolerance test (MMTT). Additionally, the rate of engraftment was higher when determined via BETA-2 score instead of MMTT ( P = 0.01). Our analysis suggests that Reparixin may have improved outcomes compared to placebo when sufficient islet mass is transplanted and when standardized immunosuppression with ATG is used for induction. However, further studies are warranted. Investigation of Reparixin and other novel agents under more standardized and optimized conditions would help exclude confounding factors and allow for a more definitive evaluation of their role in improving outcomes in islet transplantation. Clinical trial reg. no. NCT01817959, clinicaltrials.gov
Picking up Pieces of Good Corporate Governance to Sustain National Railways of Zimbabwe
Authors: Chigudu Daniel
Published: April 2021

Zimbabwe’s state-owned enterprises (SOEs) have a significant role to play in providing service delivery for basics like electricity, health, water, transport and communication. With such socio-economic importance, it is imperative that any SOE should be, transparent, accountable, effective, efficient, profitable and sustainable. However, incompetent performance has stalked most of the country’s SOEs and the National Railways of Zimbabwe (NRZ) has not been an exception. It has been caught up with successive failures and forced to rely heavily on grants from government for its sustainability. This study sought to identify the challenges in the NRZ and suggest measures to solve them and sustain the entity. A descriptive research design was employed based on a critical review and analysis of extant literature. The information and data used in this study were obtained mainly from the audit reports, research and media reports on this enterprise. Issues of governance, accountability and transparency are examined. Polices in place for good corporate governance and monitoring meant to provide guidance, and sustainability are critiqued. In light of the challenges and gaps identified in running the NRZ, recommendations to revamp the system operations are given. A field for further research is suggested which could direct future management controls.
Designing an Indigenous Voice that empowers: How constitutional recognition could strengthen First Nations sovereignty
Authors: O’Neil Jason
Published: April 2021

This article considers how a First Nations Voice to Parliament, if carefully designed, could strengthen the land-based sovereignty and autonomy of First Peoples in Australia. It critiques the proposals presented in the Indigenous Voice Co-design Process' Interim Report released January 2021 for its emphasis on the role of government and existing structures. It responds to Indigenous critiques of the Uluru Statement from the Heart, while arguing for a constitutionally enshrined Voice to Parliament that respects and defers to First Nations' Country-based authority.
Challenges, Changes, and Choices: Immigrant Academics of Color in American Academia
Authors: Delgado Rosite K. G. , Sun Qi
Published: April 2021

Immigration is a hotly debated and deeply polarizing topic in American society. The past few decades have seen an influx of immigrants from Asia, Africa, and the Americas who contend with having a double-minority status. This qualitative study advances an understanding of the lived experiences and acculturation process of immigrant academics of color within American academia. Findings indicate struggles of cultural disequilibrium, marginalization, and the challenges of gaining or regaining cultural, professional, and social capital. Their experiences and perspectives have explicit implications for adult learning.
Writing a Different Story of Music Learning
Authors: Liu Chiao-Wei
Published: April 2021

Recently, the United States has witnessed an uptick of racially and culturally motivated events that continue to challenge the role of our schools in creating a more socially just nation. In light of these issues, it is important that we consider what role school music education plays in addressing issues related to social justice. In this column, I started by sharing a class conversation on the analogies related to immigrants in the U.S. and then explored the implication of these analogies/stories. Inspired by Chinua Achebe’s analysis on literature and its relation to reality, I ask, not only what stories we tell about music learning at school, whose interest these stories serve, and whose voices/music are privileged? I propose that multiple stories of our students’ music learning may be enacted as forces to counter the dominate narrative. I end with some curriculum ideas for teachers to adapt in their classrooms.
Scaffolding the Case Analysis in an Organizational Behavior Course: Making Analytical Language Explicit
Authors: Pessoa Silvia , Mitchell Thomas D. , Gomez-Laich Maria Pia , Maune Michael , Le Roux Cecile
Published: April 2021

This article describes an innovative interdisciplinary collaboration between English faculty and an organizational behavior (OB) professor to scaffold case analysis writing in an upper-level OB course at an English-medium university in the Middle East. Case analysis writing is challenging for students as an academic genre or type of writing because they do not always know when to report on the case, when to explain OB concepts, and when to go beyond reporting or explaining by using analysis in support of claims. Combining the English faculty’s linguistic knowledge with the OB professor’s disciplinary knowledge, we developed visual support materials to make the valued features of case analysis writing explicit for students. We describe two sets of instructional materials that we used to help students meet genre expectations. We provide evidence from multiple data sources, including on-going analysis of student writing, that points to the effectiveness of our innovative interdisciplinary collaboration. Our findings provide evidence of the benefits of distributed responsibilities in teaching and assessing university students’ communication skills in disciplinary contexts, particularly for L2 learners.
Undergraduates’ Motivation Following a Zoo Experience: Status Matters but Structure Does not
Authors: Heim Ashley B. , Holt Emily A.
Published: April 2021

Background: Free-choice learning, which often takes place in settings such as zoos, is where the learner has autonomy to choose what, where, how, and with whom to learn. Currently, little is known about the potential of free-choice learning experiences at informal settings to engage undergraduates in biology. Purpose: We sought to explore how participation in structured versus free-choice learning experiences and a student’s status in their program relate to their motivation, interest, and self-regulation to learn biology after a zoo trip. Methodology/Approach: Students in both introductory and advanced biology courses were assigned to either a structured or free-choice learning group during a zoo visit. Participating students completed a set of surveys before and after the zoo trip to gauge their incoming self-regulation and changes in motivation and interest to learn biology. Findings/Conclusions: We found that advanced students reported higher intrinsic motivation to learn biology than introductory students. In addition, grade motivation decreased and self-efficacy increased after the zoo trip across all students. Implications: Ultimately, there may be numerous ways for instructors to make visits to the zoo and other informal settings more meaningful for undergraduates. Both structured and autonomous learning experiences offer benefits for students across program levels.
A Novel IRF6 Frameshift Mutation in a Large Chinese Pedigree With Van der Woude syndrome
Authors: Peng Qi , Qin Wenyan , Li Siping , Huang Meihua , Rao Chunbao , Lu Xiaomei
Published: April 2021

Aims:

Van der Woude syndrome (VWS) is one of the most common craniofacial anomalies, causing significant functional and psychological burden to the patients. This study aimed to identify the genetic cause of VWS in a Chinese family.

Methods:

Whole genome sequencing (WGS) was performed to screen for pathogenic mutations. Various Bioinformatics tools were used to assess the pathogenicity of the variants. Cosegregation analysis of the candidate variant was carried out. Interpretation of variants was performed according to the American College of Medical Genetics and Genomics guidelines.

Results:

A novel frameshift duplication c.373_374dupAA (p.Asn125Lys fs*43) was identified in exon 4 of the interferon regulatory factor 6 (IRF6) gene in all 3 affected members, which were not found in unaffected family members. The novel mutation leads to a frameshift and a premature stop codon which caused putative truncated protein. Protein alignment indicated high evolutionary conservation of the p.N125 residue, and this mutation was predicted by online tools to be damaging and deleterious.

Conclusions:

This study demonstrates that the novel mutation c.373_374dupAA (p.Asn125Lysfs*43) in the IRF6 gene corresponds to the VWS in this family. The discovery of this pathogenic variant enriches the genotypic spectrum of IRF6 gene and contributes to genetic diagnosis and counseling of families with VWS.
Policing the COVID-19 Pandemic: Exploratory Study of the Types of Organizational Changes and Police Activities Across the Globe
Authors: Maskály Jon , Ivković Sanja Kutnjak , Neyroud Peter
Published: April 2021

The COVID-19 pandemic upended major facets of global society, including policing. This study describes three types of changes that police agencies in counties worldwide made. First, how have various domains of policing changed and how much did they change? Second, were these changes regulated by the official policy? Third, what are the potential consequences of the changes made during the pandemic? Taking a mixed-methods approach, our quantitative survey data from 27 countries, buttressed by qualitative responses, enable us to examine changes in these three areas. Our results suggest there is a great deal of heterogeneity in the degree of change, the use of policy to make the changes, and the perceived effects of the changes. Some changes (i.e., the use of personal protective equipment) are relatively ubiquitous and common sense based on the pandemic. Other organizational changes show a great deal more variation, especially when considering the valence of the change. Finally, the police executives from these countries express a highly optimistic—and potentially overly rosy—view of the potential longer term consequences of the pandemic or the operational changes made because of it. Overall, the results paint a more complicated picture of the responses to the pandemic made by the police organizations included in our sample. We conclude by discussing the implications of these findings for future research, police practice, and the development of policy.
An Integrated Model of Social Impacts and Resident’s Perceptions: From a Film Tourism Destination
Authors: Kim Sangkyun , Park Eerang
Published: April 2021

Minimal research has been carried out regarding the host community’s perceptions of and reactions to film tourism impacts, utilizing a mainstream tourism destination such as Bali. This article aims to identify and explain residents’ perceptions of and attitudes toward the social impacts of film tourism, proposing an integrated theoretical model of social exchange theory, social representations theory and place change theory. Results indicate that the integrated model is particularly robust in explaining what caused a condition or event to be perceived as negative, positive or neutral place change, and why such changes are interpreted and evaluated in the social and cultural contexts. It also suggests that the locals do not perceive or necessarily respond to tourism impacts uniformly. As such, it contributes to a more wholesome understanding of the underlying dynamics and complexities involved in identifying and explaining the perceived impacts of tourism on the residents of a community in a theoretically rigorous, nuanced manner.