bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancement of bioavailability of perinodopril using lipid based nanaocarrier mediated oral drug delivery system
Authors: Pg Mahesh , Somasundaram I.
Published: May 2022

Hypertension is a serious cardiovascular event which refers to rise in the arterial blood pressure. Perinodopril which has been classified as calcium channel blocker is utilized in the treatment of hypertension. Perinodopril comes under BCS class II drug (low solubility/high permeability) which shows variable absorption pattern due to solubility limitation. Therefore, nanostructured lipid carrier (NLC) of Perinodopril was developed which is suitable for drug with high log P value as it offers the advantage of high drug entrapment and loading capacity to lipophilic drugs. Tween 80 and Poloxamer 188 were reportedly P-gp efflux inhibitors which would be an added feature to the property of Perinodopril -NLC thus enhancing drug availability across intestine. Therefore, the objectives of the present work were to develop an optimized Perinodopril -NLC using Quality by design (QbD) and evaluating it for enhancement in intestinal uptake and solubilisation fate (in physiologically simulating gastro intestinal milieu) of Perinodopril which would further enhance the oral bioavailability. Physicochemical characterization of the drug by means of UV spectra, DSC and FT-IR concluded that Perinodopril is pure and authentic. Both medium chain triglycerides (MCT) and long chain triglycerides (LCT) were used in the solubility studies of Perinodopril.
Evaluation and invivo studies of solid lipid nano carrier mediated drug delivery system of perinodopril
Authors: Pg Mahesh , Somasundaram I.
Published: May 2022

High BP is one of the most predominant causes of heart diseases and cerebrovascular problems. Perinodopril is an ACE inhibitor that is a non sulfhydryl derivative that is used for the treatment of hypertension. To enhance the effect of the drug it was formulated into Lipid based nano carrier system (NLC) to improve the bioavailability and thereby the therapeutic potential. So the objective of the current work was to evaluate the NLC of perinodopril formulation and to evaluate the same. The invivo estimation of the activity was carried out on Albino wistar rats that are maintained under room conditions and the formulation was investigated for the Pharamcokinetic and pharmacodynamic paramteres in rat plasma. Also they were tested for their stability invitro. Results show that the nano particles measured as 0.207nm in size. The invitro drug release studies suggest that the formulations were releasing the drug in controlled fashion during 23 hrs. stability studies proves the drug is very stable in the formulation. With R2 = 0.9683, the in vitro-in vivo correlation research clearly shows good agreement between in vitro drug solubilization during lipolysis and in vivo drug absorption during pharmacokinetic studies.
Genetic polymorphism of AKR1B1 with diabetic retinopathy
Authors: Alnaji Haider Ali , Hassan Azhar Hamza , Omran Rabab
Published: May 2022

Background. Diabetic retinopathy (DR) is one of the most common consequences of diabetes. Retinopathy risk may be affected by genetic polymorphisms in the AKR1B1 gene. Method. One hundred thirty-four people with diabetes enrolled in the current study with 36 health control. An ophthalmological evaluation was done along with genotyping for the AKR1B1 rs9640883 SNP for all participants. Results. The result of genotyping the rs9640883 SNP in AKR1B1 with diabetic retinopathy is a GG pattern in all recruited cases with DR or cases without this complication (134 patients) and 36 controls. The mutant AA genotype and the heterozygote GA genotype were absent in the samples. Conclusion. rs9640883 polymorphism was absent in our samples of DR, and it suggests the presence of the wild type in this locus. The A allele of rs9640883 polymorphism was absent in our samples of DR, and it suggests the presence of the wild type (G allele) in this locus.
NGAL as a biomarker in chronic kidney disease
Authors: Abdulameer Ali Nahedh , Jaffat Haider Salih
Published: May 2022

The current study was performed with 65 patients with Chronic kidney disease, their mean age (44.38±14.59) years, who have visited the physician's consultancies and the kidney disease unit at Al-Sadder Teaching hospital in Al-Najaf, Iraq, and 25 persons as a healthy control group their mean age (48.68±16.37) years. The study was conducted from September 2021 to May 2022. In this study, serum NGAL levels were measured in patients and healthy groups. It also assays the relationship between levels of these biomarkers with some hematological and biochemical parameters RBCs, Hb, PCV, Creatinine, Urea, GFR. The results revealed that there was a Significant decrease with mean± SD of RBCs, HGB, as well as PCV, (3.36±0.69 X106/ mm3), (8.99±1.76mg/dl), (28.47±4.2%) respectively of patients with kidney disease as compared with healthy groups (4.55±0.47 x 106mm3), (14.28±1.43 mg/dl), and (40.11±3.84 %) respectively. The results also shows significant difference (p-value<0.05) decreased with mean± SD of eGFR in Kidney failure patients (13.42±13.83 ml/min/1.73 m2) as compared with healthy control group (114.12±12.49 ml/min/1.73 m2).
Development of autoshg machine learning algorithm for prediction and business porting
Authors: Kadapatti Anita G.
Published: May 2022

Computational intelligence is a domain of research for a decade. The applied research provides a big way for designing and implementing the smart systems in terms of predictive analysis, automatic execution, etc. As the covid-19 pandemic given birth to many necessities, there is one segment of society is struggling to lift up their earnings. Hence, this paper presents the automation in women's self-help groups (SHGs) businesses. Paper provides a new AutoSHG machine learning algorithm which can be used for product and profit prediction, decision-making and also taking SHGs to new small E-Commerce platform. Many predictive analysis algorithms are discussed and research gaps are identified. The one hurdle for implementation of algorithm is the dataset is imbalanced in the case of SHGs and needs to be a re-generative dataset development. The proposed algorithm is very useful for world-wide SHGs society and instead of physical product prediction; this can be suitable for stepping into Pico-e-commerce concept.
Design, optimization, characterization of dapagliflozin loaded nlc using box-behnken design
Authors: Ritesh  , Chaurasia Himanshu , Singh Ranjit
Published: May 2022

Dapagliflozin used to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes is the model drug selected in the present research titled Design, Optimization, and Characterization of Dapagliflozin Loaded NLC Using Box-Behnken Design. Nano formulations are capable of providing site-specific delivery of anti-diabetic molecules to their specific site of action; this enhances the loco-regional concentration of the drug and reduces the systemic side-effects. Dapagliflozin loaded NLCs were prepared by emulsion–evaporation technique using Stearic acid as lipid and tweens & spans as surfactant. NLCs were characterized for particle size, zeta potential, entrapment efficiency and % drug release. The effects of composition of lipid materials and surfactant mixture and homogenization speed on the particle size, zeta potential, drug entrapment efficiency and in vitro drug release behavior were optimized. The optimized formulation OPT-DP-NLC has shown a particle size, entrapment efficiency and Zeta potential within projected limits, at 69.99 nm, 81.94% and -28.99 respectively.
Implementation of IoT for disease detection and prevention
Authors: Singh Guddi
Published: May 2022

An irresistible sort of infection influences countless people. A ton of examination being Led all through world. There are numerous intelligent equipment stage bundles like IoT in counting brilliant following, shrewd sensors, and clinical gadget reconciliation accessible on lookout. Arising innovation like IoT has a remarkable capacity towards hold patients secure and restorative and furthermore upgrade how doctors supply care. Medical care IoT additionally can reinforce impacted individual pride by allowing patients towards invest more energy cooperating with their clinical specialists because of reality docs aren't as taken with ordinary and repetition parts of their vocation. most impressive benefit towards IoT in medical care is that it upholds specialists in endeavor extra huge clinical work in a calling that as of now is encountering an overall expert difficult work lack. This paper researches premise investigation of relevance of IoT in medical care System.
Retinoblastoma
Authors: Aneesh Aneesh , Muneeswaran V.
Published: May 2022

Eye cancer is extremely rare. It can harm the eye's outer parts, such as the eyelid, which is made up of muscles, skin, and nerves. Intraocular cancer occurs when cancer begins inside the eyeball. Melanoma and lymphoma are perhaps the very familiar intraocular cancers in grown-up person. Retinoblastoma, which begins in the cells of the retina, seems to be the most common type of eye cancer in children. Cancer can also disperse from several other parts of the human body to the eye. Therapies for eye cancer vary depending on the type and stage of the disease. Radiation therapy, Surgery, laser therapy, and freezing or heat therapy are all the possibilities. Medical imaging techniques such as Ultrasound, Magnetic Resonance Imaging and Computed Tomography supports in obtaining the anatomical structure of the eye. By the introduction of the image segmentation algorithms, the infected portion in the eye image is segmented and the information such as the size and location of the tumor is also identified. This can assist the clinicians make more rapid and accurate diagnosis. The various studies using conventional segmentation methodologies on Retinoblastoma were reviewed in this paper.
Managing bachelors of logistics
Authors: Dung Pham Quang
Published: May 2022

Objective of the study: To evaluate the current situation in the management of training bachelors of logistics in universities in Vietnam, from there, suggesting these institutions on how to manage training bachelors of Logistics effectively, to meet the requirements of society. Method of the study: Qualitative research is mainly used, the tool is a questionnaire designed on the framework proposed by (Mangan and Christopher, 2005). The participants list has 65 people (which include: business representatives, lecturers, bachelor's training experts in the logistics industry in Vietnam), the survey was conducted during the period from June 2020 to December 2021. Result of the study: The training and teaching programs at the surveyed universities have ensured relatively adequate problem-solving skills for students; communication skills, behavior; Logistics professional knowledge. However, only about half of the knowledge in the multidisciplinary knowledge and group of skills is focused on training students.
Effect of abutment tooth geometry on the accuracy of 2 intraoral scanners
Authors: Mahdy Eslam Mostafa , Elkhodary N , Hamdy I
Published: May 2022

Aim: The aim of this in-vitro study was to evaluate the effect of abutment tooth geometry on the accuracy of two intraoral scanners. Methodology: The study was conducted using maxillary typodont. Six full coverage crown preparations were performed on central incisors, 1st premolars and 1st molars with known axial wall taper (6o and 12o) using dental parallelometer. Highly accurate table-top scanner (Identica T500) was used to obtain reference scan to the typodont. Two intraoral scanners (3shape Trios 3 and Medit i500) scanned the typodont 13 times to obtain total samples of prepared teeth (n=39) for each group. All scans were exported in standard tessellation language (STL) format. Measurements of trueness and precision for respective tooth preparation were evaluated using reverse engineering software for superimposition and deviation analysis.  Comparison between groups was performed by using One-Way ANOVA test followed by Tukey`s Post Hoc test and Independent t- test. Results: Statistical analysis showed no significant difference in trueness between the two intraoral scanners. Trueness values were 39.9 µm and 41 µm for Trios 3 and Medit i500. Trios 3 was significantly more precise (23.6 µm) compared to Medit i500 (34.7 µm).
Clinical assessment of color stability and patient satisfaction for polished versus glazed lithium disilicate glass ceramic restorations
Authors: Mosallam R. , Taymour M. , Katamish H. , Kheirallah L.
Published: May 2022

Aim: To evaluate clinically the color stability and patient satisfaction of polished versus glazed lithium disilicate glass ceramic restorations. Methodology: Twenty full coverage crowns were fabricated from IPS e. max press in the posterior area. The patients were randomly divided into two equal groups according to the applied crown surface treatment. Group 1 (control group) 10 glazed crowns and Group 2 (intervention group) 10 polished crowns. ΔE was measured using Vita easyshade and patient satisfaction was evaluated through Visual Analogue Scale (VAS), immediately after cementation and every two months for one year. Data were analyzed using two-way ANOVA and t-test. P ≤ 0.05 was considered statistically significant. Results: The results showed that the polishing technique had a statistically significant mean ΔE than glazing but both were clinically acceptable. Regarding the follow up period results showed that time had no statistically significant effect on mean ΔE values. There was also no statistically significant difference in patient satisfaction within each technique and at the different follow up times. Conclusion: Although polishing showed higher color change than glazing, it was clinically acceptable. Therefor polishing can be recommended as an alternative to glazing for IPS e.max crowns.
Open knowledge management in university education in the context of digital transformation
Authors: Tinh Tran Trung , Ha Nguyen Thi Thu , Cuong Tran Viet , Thang Pham Dinh
Published: May 2022

Research objectives: this study aims to clarify the role of knowledge in social development, and open knowledge management in higher education. Research Methods: The authors mainly use theoretical research methods. Research through documents: retrospective, summarizing, systematizing theories from domestic and foreign studies, selected documents closely related to the task of knowledge research, knowledge management, thereby, act as a scientific basis for further studies to propose appropriate measures for higher education in Vietnam in the digital transformation period in education. Research results: the study shows the role of knowledge in the process of social development. In addition, the study points out the importance of open knowledge management to the training process in universities.
Adverse effects followed by immunization with COVISHIELD and COVAXIN among health care personnel in a tertiary care hospital of India
Authors: Koyagura Narendar , Patnaik Prashanth Kumar , Konda Jaya Prakash , Vedula Prasanna , Kumar Ksheerasagar Vinay , Anumolu Goparaju
Published: May 2022

The ongoing Corona Virus Disease (COVID-19) is a pandemic disease adversely affecting health and also incurred severe financial losses globally.  Vaccination is the important preventing measure to combat COVID-19 infection. Vaccine hesitancy due to the fear of side effects is a major drawback for successful implementation of immunization programs. Extensive studies on safety of COVID-19 vaccination are much needed to address this problem. The current study aims at evaluating adverse effects following vaccination against COVID-19 infection. A total of 584 healthcare personnel who received either COVISHIELD or COVAXIN were included in the study. The adverse effects after first and second dose of vaccines in different time intervals (<24hrs, 24-48hrs, 3-7days) were recorded by using World Health Organization (WHO) based questionnaire. Among the participants, 360 received COVISHIELD and 220 received COVAXIN vaccine. Majority of the subjects experienced side effects within first 24hrs of first dose (COVISHIELD 84%, COVAXIN 90%) and also of second dose (COVISHIELD 73%, COVAXIN 89%). Side effects like general weakness, headache, fever, chills and myalgia were the most common side effects observed with both vaccines.
Post-Graduate training in Vietnam
Authors: Hang Tran Thi Minh , Trung Nguyen Dang
Published: May 2022

With the explosion of knowledge and science-technology, the development of post-graduate training programs needs to be continuously adjusted, built and enhanced to suit the needs of society. In the context of current educational innovation, the development of post-graduate training programs is a global, inevitable trend in institutions and a good solution for higher education. In this study, the author will give general comments from the manager’s angle about post-graduate training in Vietnam.
Ramalina digitellata, A New Lichen Record for Türkiye
Authors: BARAK Mehmet Ünsal , KOCAKAYA Mustafa , KOCAKAYA Zekiye
Published: May 2022

Ramalina digitellata is reported for the first time from Türkiye. Ecological and distribution information and photos of the species were given. Ramalina digitellata can be easily distinguished from other species belonging to the Ramalina genus due to the fact that the apical parts of the branches have finger-like protrusions. Besides the morphological and anatomical features, the phylogenetic tree obtained by comparing the sequence analyzes of the ITS regions was also given. The phylogenetic tree is consistent with the morphological and anatomical results.
A New Name at the Rank of Genus, Kandemiria (Asteraceae)
Authors: YILDIRIMLI Şinasi , DOĞRU KOCA Aslı
Published: May 2022

Candollea (Asteraceae), a new genus from Türkiye, was introduced to the scientific world and became homonymous. The new name of Kandemiria (Asteraceae) replaced Candollea at the rank of genus due to presence of many previous generic names for Candollea. This new genus is based on Scorzonera coriacea, S. davisii, S. elata, S. mollis, S. szowitzii and S. turkestanica of the Scorzonera s.l. species with typical features, such as perennial herb; several branched, long, erect, leafy stems; linear, nerved leaves; spiciform, raceme to subcorymbose, scape inflorescence; capitula (1)38 per stem; yellow flowers; and shortly stipitate achenes. The required new combinations of the genus and infrageneric taxa were made. As a result of the homonymous correction of the genus, a new identification key for the closely related genera of this new Kandemiria genus was provided.
Research of Speech Style Transfer Based on Neural Network
Authors: Sun Ziyi
Published: May 2022

This paper draws inspiration from image style transfer model - neural style transfer, which leads to the research topic of speech style transfer based on neural network. First, the article describes the extraction process on 2D spectrogram of speech signal. Then, the speech style transfer based on convolutional neural network is constructed.
Comparing SVM with BP to Identify the Young Females' Body Type
Authors: Zhang Suyu
Published: May 2022

Nowadays, from mass production to mass customization has occupying the domain of apparel industry. And new techniques that provide fitting apparel are needed to satisfy individual demands. In the paper, a math arithmetic using SVM(Support Vector Machine) is introduced. Firstly, a new strategy of dependency analysis is proposed. Secondly, the paper compares the approach ability of SVM and BP. Finally, some chosen feature types are used for learning and for creating the modification matrix using SVM and BP. Two model is established to identify body type. The result, which realizes auto-mapping from body data to specific estimation, has increase accuracy highly by using SVM.
Diplomazia pontificia e Comunità internazionale nel contesto del contributo della Santa Sede al bene dell’umanità
Authors: Giarnieri Enrico
Published: May 2022

SOMMARIO: 1. La funzione e il ruolo della diplomazia pontificia nella Comunità internazionale - 2. Le dimensioni dell’attività diplomatica della Santa Sede dal pontificato di Giovanni Paolo II a quello di Francesco - 3. Il riconoscimento dei diritti umani nella diplomazia di Papa Francesco - 4. A servizio della pace nel mondo - 5. Libertà religiosa, cooperazione per il bene comune e promozione della persona umana - 6. Annotazioni conclusive.

Diplomacy of the Holy See and the International Community In the context of the Holy See’s contribution to the good of mankind

ABSTRACT: The article takes into consideration the reasons and purposes for the presence of the ‘supreme governing body of the Catholic Church’ in the international Community. The author reflects on the relationship between the diplomatic activity of the Holy See and the delicate issues of peace and war. Therefore, attention is given to the methods of intervention put in place by Pope Francis with reference to the protection of fundamental human rights. In fact, from the pontificate of Paul VI, to those of John Paul II and Benedict XVI, to even the present pontificate of Francis, the juridical and geo-political questions concerning peace and terrorism, war and nuclear disarmament, the defense of religious freedom and the improvement of universal relations between states, the reform of international organizations and the promotion of human rights have strongly characterized the modus agendi of the two thousand year-old papal diplomacy. Faced with these questions, the Holy See seems to confirm both its own sui generis international juridical subjectivity and its own ‘positive neutrality’ by means of a significant work of mediation in offering universally shared solutions to protect the ontological, irrepressible dignity of the human person.
Le antiche chiese orientali e la loro conformità alla fede calcedonese
Authors: Parlato Vittorio
Published: May 2022

SOMMARIO: 1. Premessa - 2. La realtà ecclesiale e i riti - 3. La Chiesa armena gregoriana - 4. la Chiesa copta d’Egitto - 5.La Chiesa etiope e la Chiesa eritrea - 6- La Chiesa siro-giacobita - 7. La Chiesa siriaca orientale o malankarese - 8. La Chiesa assiro-orientale o caldea.

The Ancient Oriental Churches and their conformity to the calcedonese faith

ABSTRACT: Historical and doctrinal genesis of the non-chalcedon Churches and their current consistency. The recent clarification about the Christology of many of these Churches, especially in documents common with the Catholic Church.
Gesù davanti a Pilato. Rilievi procedurali su un caso di legalizzazione di linciaggio ecclesiastico
Authors: Zanchini di Castiglionchio Francesco
Published: May 2022

SOMMARIO: 1. All’origine (antropologica) del problema: tra scandalo e linciaggio rituale - 2. Competenza confessionale (legalmente pacifica) sull’accusa - 3. (intermezzo) Parallelismi tra linciaggio e scomunica - 4. (segue) Natura giuridica dell’intervento di Pilato. Una lezione di laicità.

Jesus before Pilate. Procedural remarks on a case of legalisation of ecclesiastical lynching

ABSTRACT: The Author wants to reconsider the trial of Jesus through a double critical grid: that of elimination by lynching of those who, by causing scandals, have cracked, regardless of any guilt, the certainties of the group (model dating back to immemorial times, and expression of pagan myths), and that of the execution of the death sentence issued by the great Sanhedrin of Jerusalem against the Nazarene, subject to adequate control by the Roman praetor (limited, however, only to the conditions of its admissibility by the imperial system). The discussion proceeds by underlining the full autonomy in merit of the confessional verdict, which the execution power accessed as a mere formal verification of the existence of conditions of public order considered indispensable by the State system. On the side-lines, the Author takes the opportunity to highlight how these precautions have become less and less renounceable over time, in face of the recurrent ecclesiastical claim to re-propose in new forms the ancestral logic of the ritualized lynching of discuting members.
Osservazioni su "Un’inedita e ignota recensione di Giacomo Leopardi («L’ombra di Dante»)"
Authors: Cadioli Alberto
Published: May 2022

Il breve libro di Christian Genetelli, Un’inedita e ignota recensione di Giacomo Leopardi («L’ombra di Dante») (Milano, LED-Edizioni universitarie, 2020, collana Palinsesti, diretta da William Spaggiari), presenta una carta inedita di Giacomo Leopardi, sfuggita ai tanti studiosi che hanno compulsato l’archivio del poeta conservato presso la Biblioteca Vittorio Emanuele di Napoli, o da loro valutata di poco conto. Le modalità con le quali Genetelli la presenta meritano una particolare attenzione, almeno per due ragioni: una prima, naturalmente, relativa a Leopardi, e una seconda perché esemplifica bene il metodo di indagine storico-filologico che, ancora una volta, si conferma di grande efficacia per la conoscenza di un testo e del suo autore.
EFFECTS OF DROUGHT AND BIOGAS WASTE WATER APPLICATIONS ON MAIZE SEEDLING GROWTH
Authors: Zahoor MJ , Robina K , Rafi R , Abbas HG
Published: May 2022

Plant growth and development are influenced by a variety of biotic and abiotic factors. Drought and salinity are major constraints for the growth of plants all over the world. Maize has received attention because of their massive production in drought and salt stress. So, an experiment was conducted for improving the knowledge about the performance of maize seedlings behind the drought tolerance in different varieties of maize. Seeds of maize were submitted to different stress treatments like drought, wastewater, and biogas with the objective of evaluating the effects of drought, wastewater, and biogas treatments on early seedling growth. EV-1097Q, Raka-Poshi, Pak-Afgoi seeds were sown in 36 pots which were filled with 1.5kg of sand. Then stress treatments were applied and results were observed.  The results were observed for eleven variables which are root length, shoot length, leaf area, and root shoot weight ratio. From the results, it was found that these selected genotypes of maize showed a different level of tolerance to the stress treatments. Most of the genotypes have shown negative results which means that they did not tolerate the stress treatments. In the future, there is a need for exploratory research for understanding the mechanism behind tolerance.
Detección de Adenovirus Entéricos en infantes con enfermedad diarreica aguda de la Ciudad de Chihuahua
Authors: De La O-Contreras Carmen Myriam , Zermeño-Ortega Miriam Rosario , Manjarrez-Nevárez Laura Alicia , Reyes-Martínez Reyna
Published: May 2022

El objetivo del estudio fue detectar la presencia de Adenovirus entéricos en muestras de heces de infantes menores de cinco años con enfermedad diarreica aguda (EDA) en la ciudad de Chihuahua, México, en el período de 2004 a 2008 y 2012. Se analizaron un total de 236 muestras de heces diarreicas provenientes de infantes hospitalizados con EDA de la ciudad de Chihuahua, México, con la técnica PCR utilizando los iniciadores Hex1deg y Hex2deg. Se determinaron los serotipos entéricos, en las muestras positivas para Adenovirus, mediante el patrón de las enzimas de restricción HaeIII y Hinfl obtenidos de los productos de PCR. Los resultados obtenidos revelaron que el 24 %, de las 236 muestras analizadas fueron positivas para Adenovirus entéricos, de las cuales 22.3 % correspondieron al serotipo 41 y 1.7 % al serotipo 40, con una mayor cantidad de casos en el período invernal. Con este estudio se detectó la presencia de Adenovirus entérico como agente etiológico de EDA en infantes menores de cinco años en la ciudad de Chihuahua, México, en el periodo 2004-2008, además se encontró la presencia de Adenovirus no entéricos sugiriendo su atención en el futuro como agentes causales de EDA.
PENGUASAAN NEGARA DAN PERAN MASYARAKAT ATAS SEKTOR PERTAMBANGAN MINERAL DAN BATUBARA
Authors: Silviana Putri Szyva
Published: May 2022

Indonesia has a lot of natural resources, one of which is minerals and coal. Of course, in its management must be with the attention and role of the government in the management of these resources. The role of the government in mastery in the mining sector is needed. What's more, the mining sector is a sector that is in great demand by foreign investors, so the government must take part in regulators to regulate exploitation in the mining sector. so that the creation of balance in its use or management which of course must be based on the welfare of the people. Therefore, the guidelines for the rule of law in the management of minerals and coal are needed in their application. So that in carrying out and managing it in accordance with the NRI Constitution, as well as the applicable law in order to get maximum utilization of natural resources without damaging nature, so that posterity can feel and utilize it as well
PENINGKATAN TRANSAKSI PRODUK SIMPANAN DI KOPERASI SYARIAH MELALUI ETIKA PEMASARAN ISLAM
Authors: Rohmatuzzakiyah Alvi , Sadiqin Amin
Published: May 2022

Penelitian ini bertujuan untuk mengetahui Etika pemasaran yang diterapkan oleh KSPPS Muamalah Berkah Sejahtera dalam meningkatkan Transaksi Produk Simpanan nya. Metode yang peneliti gunakan dalam penelitian ini adalah metode penelitian deskriptif dengan pendekatan kualitatif. Penelitian ini dilaksanakan pada bulan Maret tahun 2022. Jenis data yang digunakan pada penelitian ini adalah data primer, yaitu data penilaian dari anggota dan etika pemasaran. Sedangkan data sekunder, yaitu penelitian terdahulu. Terdapat dua sumber data pada penelitian ini, yaitu sumber data primer yang berupa wawancara dengan informan. Sedangkan sumber data sekunder buku dan jurnal terkait pemasaran islam, simpanan koperasi syariah, etika bisnis islam. Teknik pengumpulan data yang digunakan pada penelitian ini adalah wawancara, observasi dan dokumentasi. Terdapat 3 langkah dalam teknik pengolahan data yang digunakan pada penelitian ini yaitu editing, organizing dan analyzing. Berdasarkan hasil penelitian pada bab sebelumnya, maka dapat disimpulkan bahwa pemasaran yang dilakukan KSPPS MBS telah sesuai dengan teori atau konsep marketing islam yang terdiri dari praktik dan etika pemasaran yang sesuai dengan sifat Nabi Muhammad SAW dan Al-Ghazali. Etika pemasaran islam yang diterapkan di KSPPS MBS sudah menjadi budaya kerja bersama baik pada atasan sampai dengan bawahan dalam memjalankan tugasnya sebagai pemasar. Hal ini dapat dilihat dari bertambahnya jumalah keanggotaan koperasi dari tahun ke tahun.
OBTAINING AND RESEARCH OF PALLADIUM COMPLEXES WITH 4-AMINOPIRIDINE
Authors:   «OilGasScientificResearchProject» Institute, SOCAR, Baku, Azerbaijan, Gasanov Kh.I. , Ajalova G.I. , Gasimov Sh.H.
Published: May 2022

The obtaining and investigation of various complex compounds of the biologically active aromatic heterocyclic ligands with platinum and palladium are of interest due to their potential medical applications. To that end, 4-amino pyridine containing cyclic and exocyclic nitrogen atoms has been used. The main aim of this work is to clarify which nitrogen atom of the ligand composes stronger and more stable bond. As a result of IR-spectroscopic investigation of synthesized complexes, the acquired information demonstrated that the pyridine nitrogen atom of the ligand is protonated and composes outer sphere as monocharged cation. However, tetraacidoanion is formed in the inner sphere. In the alkaline medium the ligand is monodentately coordinated with palladium through nitrogen atom of pyridine. The exocyclic nitrogen atom of the ligand does not participate in the coordination regardless of pH of the medium and stoichiometric ratio of the taken compounds The initial biological probes were accomplished and the correlation between their biological activities, composition and structures of complexes were determined.
OBTAINING OF METAL-DEL BIOCOMPLEXES WITH Cu (li), Co (li) AND Ni (li) IONS OF POLY-N-VINYLPYRROLIDONE AND STUDY OF IMMOBILIZATION OF THRIPS TO THEM
Authors:   «OilGasScientificResearchProject» Institute, SOCAR, Baku, Azerbaijan, Tapdigov Sh.Z.
Published: May 2022

Metal gel complexes of Cu (II), Co (II) and Ni (II) ions of hydrogels obtained by construction of poly-N-vinylpyrrolidone (PVPr) with N, N-methylene bisacrylamide (MBAA) with average molecular weight of 10 kDa and 40 kDa were synthesized. The capacity of the obtained biologically important complexes for metal ions was determined to be 3.3-3.6 mg/g. Immobilization of trypsin in polymer-metal complexes was carried out, and for thrips of metal gel complexes, the capacity was increased by 7-8 times, the degree of immobilization by 2 times, and the specific activity of the enzyme from 38 to 92 ED/mg. It was found that triple polymer-metal-trypsin systems have greater communication resistance than polymer-trypsin binary systems, which is due to the binding of trypsin to the polymer network by metal ions. In addition, the structure of the obtained complexes was identified by IR-Fourier and UV spectroscopic methods.
Comparative Analysis of Teaching Strategies Used in Lessons on Culture and Lessons on Heritage of a Selected Chinese-Filipino School
Authors: Mainit Karen Pedernal , Leon John Angelo Vinuya De
Published: May 2022

This paper seeks to identify the teaching strategies used in Grade 4 Culture and Heritage lessons in a Chinese-Filipino School. Further, it is important to effectively address these with constructivist-based teaching strategies to help maximize the learning experience. This study used qualitative method where Ethnographic research design and Descriptive method were used to conduct classroom observations. The instruments used to obtain the results were patterned and modified from Craig Kissock’s (1981) Curriculum Planning for Social Studies Teaching: A Cross-cultural Approach, a self-made Teachers’ Self-evaluation form and Peer Observation form participated by nine teachers of a Chinese-Filipino School in Quezon City, Philippines. The analysis of the results identified five teaching strategies with Discussion and Lecture strategy as the most applied alongside Game strategy, Question and Answer strategy, and Project method. Other activities that strengthened the Culture and Heritage awareness were integrated through a collaborative effort with other subject areas. As a result, the study supported that Social Development theory affects the teaching-learning process where opportunities for social interaction helps in the development of a child. Using various teaching strategies encouraged students to interact with one another, to freely express their thoughts, and to participate in fun and healthy competition. It also encouraged students to think and to unleash their creativity and imagination. At the same time, the use of tools and other resources helped increase student engagement.
PENGARUH MODEL PEMBELAJARAN DARING TERHADAP HASIL BELAJAR MATA KULIAH MEDIA PEMBELAJARAN DI MASA COVID-19 MAHASISWA PROGRAM STUDI PENDIDIKAN TEKNIK MESIN FAKULTAS TEKNIK UNIVERSITAS NEGERI MAKASSAR
Authors: Anwar Badaruddin , Adam Asmah , Ismail Ismail
Published: May 2022

Penelitian ini adalah penelitian kuantitatif yang bertujuan untuk mengetahui pengaruh model pembelajaran daring terhadap hasil belajar Mata Kuliah Media Pembelajaran di masa Pandemi Covid-19. Subjek penelitian ini adalah Mahasiswa Program Studi Pendidikan Teknik Mesin Fakultas Teknik Universitas Negeri Makassar. Teknik pengumpulan data yang digunakan adalah menggunakan kuesioner untuk data model pembelajaran daring dan studi dokumentasi untuk data hasil belajar Media Pembelajaran. Data penelitian ini dianalisis statistik deskriptif dan regresi linear sederhana. Hasil yang diperoleh menunjukkan bahwa model pembelajaran daring berpengaruh signifikan sebesar 22,3% terhadap hasil belajar Mata Kuliah Media Pembelajaran. Persamaan regresi yang diperoleh dalam penelitian ini adalah Y= 2,196 + 0,013X. Penelitian ini diharapkan dapat menjadi referensi pada pendidikan mengenai efektivitas pembelajaran daring selama Pandemi Covid-19 terutama di Universitas Negeri Makassar.
การศึกษาคุณลักษณะความสามารถในการคิดเชิงบริหารสำหรับเด็กปฐมวัย
Authors: นันตาเขียน วรรธนา , สุธาสิโนบล กิตติชัย , แย้มรุ่ง รุ่งทิวา , ลังกา วิไลลักษณ์
Published: May 2022

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อศึกษาคุณลักษณะความสามารถในการคิดเชิงบริหารสำหรับเด็กปฐมวัย กลุ่มตัวอย่างได้แก่ ผู้ทรงคุณวุฒิด้านการศึกษาปฐมวัย ผู้บริหาร ครูผู้สอนในโรงเรียน ผู้ปกครองนักเรียน จำนวน 8 ท่าน เครื่องมือที่ใช้ในการศึกษาครั้งนี้ คือข้อคำถามในการสนทนากลุ่มเกี่ยวกับคุณลักษณะความสามารถในการคิดเชิงบริหารสำหรับเด็กปฐมวัย จำนวน 15 ข้อ โดยคัดเลือกจากผลการตรวจสอบค่าดัชนีความสอดคล้อง (IOC) ของคำถามเกี่ยวกับคุณลักษณะความสามารถในการคิดเชิงบริหารสำหรับเด็กปฐมวัย ที่มีค่าเฉลี่ยเท่ากับ 0.5 ขึ้นไป ผู้วิจัยใช้วิธีการบันทึกการสนทนากลุ่ม (Focus Group Discussion) และนำเสนอด้วยข้อความเชิงบรรยายที่ประกอบด้วยคุณลักษณะความสามารถในการคิดเชิงบริหารสำหรับเด็กปฐมวัย

ผลการวิจัยพบว่า ผลการสนทนากลุ่มกับผู้เชี่ยวชาญและผู้ปฏิบัติ โดยมีความคิดเห็นตรงกันว่าคุณลักษณะของความสามารถในการคิดเชิงบริหารสำหรับเด็กปฐมวัยควรมี 3 ด้าน ได้แก่ ด้านการยับยั้งชั่งใจ ด้านการเปลี่ยนความคิดและด้านการควบคุมอารมณ์
Perspectiva y representación arquitectónica
Authors:   McGill University, Pérez Gómez Alberto
Published: May 2022

Las herramientas de representación no son nunca neutrales, al contrario, son la razón fundamental de la elaboración onceptual de los proyectos arquitectónicos y del proceso de generación de la forma. Incitados por las cambiantes tecnologías informáticas, los arquitectos contemporáneos a veces reconocen las limitaciones de las herramientas de ideación; de hecho, todavía se espera que plantas, alzados y secciones predigan con exactitud un significado intencionado tal y como aparecería ante un sujeto situado en la obra construida. De cualquier modo, hasta ahora no se ha considerado seriamente ninguna alternativa significativa para la generación de la forma al margen del dominio del moderno perspectivismo epistemológico, esto es, del entendimiento del proyecto como una “imagen.”
1963-2013. 50 AÑOS DEL INSTITUTO DE INVESTIGACIONES ESTÉTICAS, HOY INSTITUTO CARLOS ARBELÁEZ CAMACHO PARA EL PATRIMONIO ARQUITECTÓNICO Y URBANO EN BOGOTÁ
Authors:   Kioto University, Niglio Olimpia
Published: May 2022

Con los primeros 50 años del Instituto de Investigaciones Estéticas, hoy Instituto Carlos Arbeláez Camacho para el patrimonio arquitectónico y urbano en Bogotá, este artículo tiene como finalidad recorrer las etapas fundamentales del desarrollo de la cultura de la restauración en Colombia gracias a la obra del profesor Carlos Arbeláez Camacho. Su obra se desarolló en un contexto cultural muy complejo donde la práctica de la conservación del patrimonio cultural no era de interés para la comunidad más interesada a la modernización del país. Sin embargo el trabajo de sensibilización desarrollado por Carlos Arbeláez Camacho con sus alumnos ha puesto las bases por una cultura de la restauración, hoy con más de cincuenta años de historia y de experiencias muy interesantes.
Carta Editorial 2
Authors:   Instituto Politécnico Nacional, Pastrana Salcedo Tarcicio
Published: May 2022

En el ámbito de la conservación arquitectónica, los debates son frecuentes, son parte intrínseca de una actividad multidisciplinaria que presenta aristas, zonas y diferentes puntos de vista que se plasman en etapas históricas, ideas y soluciones. Por consiguiente es común discrepar, tener diferencias que existan en múltiples discusiones realizada con el anhelo de expresar una idea, una opinión. Ese anhelo de debatir es la sangre que corre y vitaliza una actividad que básicamente busca preservar los vestigios de épocas pasadas.
Carta Editorial 3
Authors:   Instituto Politécnico Nacional, Pastrana Salcedo Tarcicio
Published: May 2022

La tecnología es una aplicación. Aterriza los conocimientos científicos, los convierte en bienes, productos y servicios. Según el diccionario de la RAE(2015) en su primera definición tecnología es: “Conjunto de teorías y de técnicas que permiten el aprovechamiento práctico del conocimiento científico”.
CARATERÍSTICAS DA RESPOSTA IMUNE INATA NA DOENÇA DE ALZHEIMER
Authors: Passos Amábylle Costa , Morais Alanna Michely Batista de
Published: May 2022

Objetivo: definir quais as características da resposta imune inata na doença de Alzheimer. Métodos: efetuou-se uma revisão integrativa da literatura, utilizando-se a seguinte questão de pesquisa: “Quais as características da resposta imune inata na doença de Alzheimer?”. Utilizaram-se as bases de dados Medical Publisher (PubMed) e Science Direct, totalizando a amostra final de 14 artigos. Resultados: as principais características da resposta imune inata na doença de Alzheimer são a participação ativa na regulação de processos neuroinflamatório e de plasticidade neuronal, por meio das células de defesa da micróglia e de neuroreceptores existentes no tecido cerebral, como o TREM2 e a proteína tau. A regulação na formação e degradação de placas de peptídeo beta-amiloide (Aβ) é também importante na patogênese da doença de Alzheimer e as células de defesa do sistema imune inato participam ativamente nesse processo. Considerações finais: pode-se afirmar que as células de defesa do sistema imune inato possuem um papel fundamental na patogênese da doença de Alzheimer. A regulação da neuroinflamação possui relação com lesão neuronal e equilíbrio das células neuronais, sendo essencial sua regulação adequada para evitar atrofia neuronal.
CONSEQUÊNCIAS PSICOSSOCIAIS ENTRE PROFISSIONAIS DE SAÚDE DECORRENTE DA PANDEMIA DO COVID-19
Authors: Araújo José Luíz neto Ferreira de , Souza Waerson José De , Sousa Milena Nunes Alves de
Published: May 2022

RObjetivo: Apresentar e exemplificar o desfecho das consequências psicossociais nos profissionais de saúde decorrente da pandemia do COVID-19. Método: trata-se de uma revisão sistemática da literatura realizada por meio da busca por publicações científicas indexadas nas bases de dados Biblioteca Virtual em Saúde (BVS), Medical Publisher (PUBMED) e Scientific Electronic Library Online (SCIELO). Os seguintes descritores foram utilizados: “Saúde mental”, “Profissionais de saude”, “Linha de frente”e “COVID-19”. Resultados: a análise dos estudos evidenciou que o trabalho árduo dos profissionais de saúde na linha de frente direto para pacientes infectados com SARS-CoV-2 tem expostos esses profissionais a ambientes e jornada de trabalho desfavorável, com jornada longa e sobrecarga de trabalho e recursos limitados para agir e controlar a propagação do vírus, levando em consideração esta intensa jornada de trabalho, esta situação, além do medo de contágio, causou sofrimento mental e físico para profissionais de saúde, devido o desconhecimento da doença e alta transmissibilidade do vírus, muitas deficiências foram vistas na saúde pública com o desenvolver do novo cenário. Conclusão: Instituições de saúde devem refletir profundamente sobre o seu papel na promoção, manutenção e criação de atividades e programas de prevenção do sofrimento psíquico ou transtornos mentais identificados nos profissionais de saúde que nelas atuam. Estas contribuirão para a organização de melhores estratégias que preservem a saúde mental dos profissionais, com consequências positivas na sociedade como um todo.
ALOPECIA ANDROGENÉTICA: MINOXIDIL ORAL VERSUS OUTRAS TERAPIAS MEDICAMENTOSAS
Authors: Figueirêdo André Mendes , Egypto Lívio Vasconcelos do
Published: May 2022

Objetivo: Analisar a terapia com o minoxidil oral para a alopecia androgenética e comparar com outras terapias medicamentosas. Métodos: Esse estudo trata-se de uma revisão sistemática da literatura, de caráter qualitativo, que utilizou-se da base de dados do Medical Publisher (PUBMED) e da Biblioteca Virtual em Saúde como fonte de pesquisa, pesquisa essa com objetivo de encontrar artigos que respondessem a questão norteadora “Em pacientes com Alopecia Androgenética, quais os efeitos do tratamento com minoxidil oral em comparação com outras terapias medicamentosas?”. A população alvo desse estudo são os pacientes com AGA que fazem uso de alguma terapia medicamentosa. Resultados: A AGA é uma doença muito prevalente na população mundial, trazendo outras sequelas além da perda de cabelo. Dentre as alternativas para o seu tratamento tem-se: minoxidil oral e tópico, finasterida oral, Plasma Rico em Plaquetas, Fatores de Crescimento de Fibroblasto, cetirizina tópica, fototerapia, etc. Alguns grupos de pacientes relataram efeitos adversos a depender da medicação empregada. Conclusão: Dentre as opções de tratamento, a associação de 2 terapias mostrou resultado superior em relação as monoterapias. Embora algumas reações adversas tenham sido relatadas, poucos pacientes tiveram que interromper o tratamento por conta delas.
ЗНАЧЕНИЯ ТЕРМОТОПОГРАФИИ И ПРАВО-ЛЕВЫХ ГРАДИЕНТОВ ТЕМПЕРАТУРЫ КОЖИ НОВОРОЖДЕННЫХ
Authors: Мавжуда Абдуллаева
Published: May 2022

Аннотация. В статье представлены результаты исследований термотопографии кожи новорожденных, право-левые градиенты температуры кожи на отдельных участках тела у новорожденных в зависимости от пола. Показано, что в первый месяц жизни ребенок обладает высокой активностью так называемого «несократительного» термогенеза, за счет бурой жировой ткани, обладающей высокими энергетическими возможностями. В работе отмечено, что у мальчиков активация теплопродукции бурого жира высокая, чем у девочек, что обеспечивает более высокую температуру на некоторых участках тела. Результаты исследования показали, что новорожденные, рождающиеся с нормальными основными антропометрическими данными, не однородны по зрелости и температурным градиентам в сравнении по полу.
ОРГАНИЗАЦИЯ МЕДИЦИНСКОГО ОБЕСПЕЧЕНИЯ ОБРАЗОВАТЕЛЬНОГО ПРОЦЕССА В СОВРЕМЕННЫХ УСЛОВИЯХ КАК ФАКТОР, ОПРЕДЕЛЯЮЩИЙ СОСТОЯНИЕ ЗДОРОВЬЯ ДЕТЕЙ ШКОЛЬНОГО ВОЗРАСТА (обзор литературы)
Authors: Abdumuxtarova Madina
Published: May 2022

Значительное влияние на состояние здоровья детей оказывает обучение в образовательных организациях, которое совпадает с периодом интенсивного роста и развития детского организма. Систематическое и длительное воздействие факторов школьной среды накапливается и приводит к различным нарушениям здоровья. Степень влияния школьных факторов зависит также от исходного состояния здоровья ребѐнка. Развитие и интенсификация школьного образования обострило проблему сохранения здоровья учащихся. Среди детей, начинающих регулярное обучение, увеличивается распространѐнность пограничных расстройств здоровья с формированием в дальнейшем хронической патологии, поэтому особенно актуален поиск методов ранней донозологической диагностики и профилактики заболеваний. В связи с этим Всемирная организация здравоохранения одним из приоритетных направлений определяет поддержку здоровья, укрепление безопасности и благополучия детей и подростков. Разработаны стандарты качества школьных медицинских услуг, которые должны обеспечить укрепление здоровья молодых людей во всех образовательных учреждениях. Несмотря на признание того, что задачи по сохранению и укреплению здоровья современных школьников могут и должны решаться непосредственно в образовательном учреждении, до сих пор не найдены универсальные и эффективные формы организации учебного процесса, не решѐн вопрос оптимизации двигательной активности, питания учащихся. Актуальной разработка новых концептуальных положений организации профилактики с использованием системного подхода, изменения роли врача как организатора школьного здравоохранения и научно обоснованной интеграции педагога в систему профилактики нарушений развития и состояния здоровья детей школьного возраста.