bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Innovations in Education: Students Satisfaction and Career Adoptability
Authors: Tutar H. , Karademir O. , Guler S. , Tutar S.
Published: January 2020

Open and distance education, unlike the traditional style of education, does not have to come to the campus, courses are processed in a completely virtual environment through the computer, live and interactive is the name of the training that the participant can watch them again and again at any time. Open and distance education in this aspect; Student Centre is an ideal educational model for people who cannot benefit from traditional education, providing equal opportunities, providing education opportunities for physically disabled students, eliminating geographical and regional barriers. Besides, it is a modern and innovative education model that ensures the continuation of the education of the people working in their businesses. Career compliance is a process that starts from preparation for the profession and starts from employment, progress in career and ending a career. Career compliance reflects an individual’s capacity to cope with potential changes that may arise in the present and future business life. Besides, employees’ level of coping with new job responsibilities, unexpected career changes and the ability to overcome obstacles that may arise. The main purpose of this study is to examine the relationship between education satisfaction levels and career adaptability perceptions of participants taking education within open or distance education model. The study is important in terms of developing and improving the open or distance education model when considering that the number of people taking education within the open or distance education model in our country is more than three and a half million today. Besides, one of the important issues in working life in contemporary societies is the career issue and it is thought that the adaptability of employees with their occupations has an important role in their productivity. Therefore, determining the level of educational satisfaction and career adaptability is thought to be important. In the study, which is based on «lifelong learning theory», the quantitative research method was preferred. To collect data, the «Distance Education Satisfaction Scale» and the «Career-related Adoptability» scales were employed. Data collected from a sample of 527 individuals were analysed by difference, relationship and impact tests and it was found that distance education satisfaction had a positive effect on career adaptability.
Keywords: education satisfaction, career adaptability, distance education, open education, e-learning.
New insights on Br speciation in volcanic glasses and structural controls on halogen degassing
Authors: Louvel Marion , Cadoux Anita , Brooker Richard A. , Proux Olivier , Hazemann Jean-Louis
Published: January 2020

The volcanic degassing of halogens, and especially of the heavier Br and I, received increased attention over the last 20 years due to their significant effect on atmospheric chemistry, notably the depletion of stratospheric ozone. While the effect of melt composition on halogen diffusion, solubility, or fluid-melt partitioning in crustal magma chambers has been thoroughly studied, structural controls on halogen incorporation in silicate melts remain poorly known, with only few studies available in simplified borosilicate or haplogranite compositions.

Here, we demonstrate that high-energy resolution fluorescence detection X-ray absorption spectroscopy (HERFD-XAS) with a crystal analyzer spectrometer (CAS) is well-suited for the study of Br speciation in natural volcanic glasses which can contain lower Br concentrations than their laboratory analogs. Especially, HERFD-XAS results in sharper and better-resolved XANES and EXAFS features than previously reported and enables detection limits for EXAFS analysis down to 100 ppm when previous studies required Br concentrations above the 1000 ppm level. XANES and EXAFS analyses suggest important structural differences between synthetic haplogranitic glass, where Br is surrounded by Na and next-nearest oxygen neighbors, and natural volcanic glasses of basaltic to rhyodacitic compositions, where Br is incorporated in at least three distinct sites, surrounded by Na, K, or Ca. Similar environments, involving both alkali and alkaline earth metals have already been reported for Cl in Ca-bearing aluminosilicate glass and our study thus underlines that the association of Br with divalent cations (Ca2+) has been underestimated in the past due to the use of simplified laboratory analogs. Overall, similarities in Cl and Br structural environments over a large array of compositions (46–67 wt% SiO2) suggest that melt composition alone may not have a significant effect on halogen degassing and further support the coupled degassing of Cl and Br in volcanic systems.
Personnel management professional standards: development and implementation in Ukraine
Authors: Kravchuk Oksana
Published: January 2020

The transformation of the modern labor market, the development of the educational services market and changes in the field of implementation of the personnel management function are accompanied by a number of problems that be facilitated by the introduction of professional standards in personnel management in Ukraine. The relevance of this research is exacerbated by the need to move the personnel management system in the country to a new quality level, to organize work with people in accordance with international standards and best practices, and to reform the state personnel policy. Therefore, it is relevant to justify the need and opportunities of developing a personnel management professional standard, to summarize its methodological aspects, and to generate recommendations for implementing activities of HR-departments and specialized educational institutions. The article deals with the current state of scientific research and regulation of development and implementation of professional standards in personnel management. It also substantiates the influence of professional standards on the development of personnel management, the system of vocational education and the quality of supply on the labor market in the personnel management segment. Stakeholder interests are broadened to develop and implement professional standards in HR. Proposals to improve methodological support for the development of personnel management professional standards have been developed. Prospective directions of introduction and use of personnel management professional standards in Ukraine are offered.
Treatment of acute lymphoblastic leukemia in children: a review of literature
Authors: Aleskerova G. A.
Published: January 2020

The article tells about the main stages of improving treatment regimens for acute lymphoblastic leukemia (ALL) in children, from monotherapy with prednisolone and 6-mercaptopurine to novel multicomponent risk-adapted chemotherapy protocols. The focus is on evaluating risk factors which varied with the expansion of knowledge about the molecular biological profile of ALL. Only the detailed analysis of the clinical and immunobiological characteristics of ALL allowed to develop novel, highly effective treatment schemes leading to recovery in over 80% of patients.
Hemorrhoids in pregnant and postpartum women: principles of therapy
Authors: Lomova N. A. , Dubrovina N. V. , Dragun I. E. , Tolstopyatova E. S.
Published: January 2020

Hemorrhoids is one of the most common diseases during pregnancy and in the postpartum period. It can be acute and chronic, and manifests itself in the form of thrombosis, inflammation or bleeding. The course of the disease can be either chronic or acute. Acute hemorrhoids is a complication of the chronic process and is further subdivided into forms according to the severity of inflammation and thrombosis. The classification reflects the pathogenesis of hemorrhoids; it is convenient and practical allowing for an unbiased approach in outlining indications and selecting the desired method of treatment depending on the stage of the disease and its severity. Conservative treatment of acute and chronic hemorrhoids is aimed at relief of symptoms of acute hemorrhoids, preventing complications as well as exacerbations of the chronic disease. Medications used in the treatment have anti-inflammatory, analgesic, hemostatic effects, improve blood flow and blood circulation in cavernous formations. The article tells about the drug of choice in the treatment of hemorrhoids in pregnant and postpartum women.
Synthesis and application of magnetized nanoparticles to remove lead from drinking water: Taguchi design of experiment
Authors: Jalees Muhammad Irfan
Published: January 2020

Contamination in drinking water from heavy metals like Pb2+ has severe effects on health. In this study, potato peel (PP) was used as the substrate and magnetic iron nanoparticles (MI) were deposited on PP using a co-precipitated method. Fourier transformation infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis confirmed the deposition of MI on PP. The L16 (4^4) method of Taguchi design of experiment (DOE) was used for the optimization of adsorption condition, i.e., at 6 pH, 10 min of contact time, and a dose of 15 g/L can give more than 90% removal efficiency of Pb2+ using PP-MI. Contour maps, Taguchi response analysis, and analysis of variance (ANOVA) suggested that pH has a dominant contribution in the removal of Pb2+. The adsorption process was favorable, spontaneous, and exothermic in nature and was followed by pseudo second order kinetics. A comparison of the sorption capacity of PP-MI for Pb2+ with literature values suggested that PP-MI has good potential for the removal of Pb2+.

This article has been made Open Access thanks to the generous support of a global network of libraries as part of the Knowledge Unlatched Select initiative.
Biofilme a partir de gelatina e glicerol com a adição de íons de prata como agente antimicrobiano
Authors: Leite Inacio de sá , Pinto Jr Wilson Rodrigues , SILVA LEONARDO DE ARAÚJO
Published: January 2020

O interesse por embalagens biodegradáveis tais como os bioplásticos está aumentando porque o uso de materiais e recursos renováveis contribui para a preservação ambiental. Entre todos os biopolímeros, a gelatina está sendo pesquisada como um material com grande potencial para elaboração de filmes biodegradáveis. O objetivo deste estudo foi à elaboração de um biofilme de gelatina e glicerol com propriedade antibacteriana. O bioplástico formulado na proporção 1:1 (16% de gelatina e 16% de glicerol) apresentou aspecto homogêneo, transparente, com ausência de bolhas na superfície e boa flexibilidade (facilidade de manuseio e ausência de rupturas e zonas quebradiças). O filme apresentou total solubilidade em ácido clorídrico 1N e a análise de biodegradabilidade indicou uma perda de massa total durante 30 dias enterrados no solo.  A solução de íons de prata teve um efeito bactericida, com base na concentração inibitória mínima (1 mg. mL-1, 0,5 mg. mL-1, 0,25 mg. mL-1) testada, frente ao microrganismo Escherichia colli ATCC 25922. Esse efeito continuou presente quando os íons de prata (1 mg. mL-1) foram adicionados no biofilme, visto que para todos os filmes testados foram observados halos de inibição maiores ou iguais a 30 mm. Os resultados apontam perspectivas da utilização do biofilme formulado a base de gelatina com adição de íons de prata na categoria de embalagens ativas.
Zihinsel Yetersizliği Olan Öğrencilere Matematiksel Kavram ve Becerilerinin Öğretimine Yönelik Öğretmenlerin Sınıf İçi Uygulamalarının Belirlenmesi
Authors: Çay Evgin , Yıkmış Ahmet
Published: January 2020

Bu araştırmanın amacı; hafif düzey zihinsel yetersizliği olan öğrencilere matematiksel kavram ve becerilerinin öğretimine yönelik öğretmenlerin sınıflarında yaptıkları uygulamaları incelemektir. Araştırmanın örneklem grubunu Sakarya’da özel eğitim okulunda çalışan 10 özel eğitim öğretmeni oluşturmaktadır. Verilerin toplanmasında, görüşme türlerinden yarı yapılandırılmış görüşme tekniğinden yararlanılmıştır. Araştırmacılar tarafından hazırlanan yarı yapılandırılmış görüşme soruları kullanılarak veriler toplanmıştır. Verilerin çözümlenmesinde betimsel analiz kullanılmıştır. Araştırmanın sonunda özel eğitim okulunda çalışan öğretmenler, matematiksel kavram ve becerilerin öğretimi sırasında bireyselleştirilmiş eğitim ve öğretim planı yaptıklarını ifade etmişlerdir. Öğretmenler, matematiksel kavram ve becerilerin öğretimi sırasında öğrencilerin dikkatini çekmeye ve sürdürmeye yönelik öğrencinin yakın çevresinden örnekler verdiğini ifade etmişlerdir.
Türklerin Düğün Geleneklerinde Özgün Bir Tasarım: Gelin Habercisi Çengel
Authors: Gürcan Akbaş Kevser
Published: January 2020

Türk kültüründe evlenme önemli bir olgudur. Efsaneler, hikayeler, masallar, mitler gibi kültürel taşıyıcılığın etkin araçlarıyla aktarılagelenler, Türklerin tarihleri boyunca yaşadıkları coğrafyalarda sayısız çeşitlilikte evlenme ritüeli gerçekleştirdiklerini göstermektedir. Evlenme, toplumun en küçük yapı taşı olan aile oluşumunun başlangıcıdır. Doğum ve ölümün yanısıra insan ve toplum hayatını düzenleyen üç geçiş döneminden biridir. Kişinin özellikle de kadının bir taraftan diğer tarafa geçişini temsil etmektedir ve merkezinde gelin yer almaktadır. Türk inanışlarında “gelinin göçü” olarak da ifadesini bulan bu mitolojik yolculuğun özünde, gelinin baba ocağından yeni yurduna gidişin ötesinde yaradılış mitlerinden günümüze kültürel seyahatimizin şifreleri korunmaktadır. Bugün Anadolu düğün adetleri aynı geçmişte olduğu gibi sayısız çeşitliliğe ve anlam zenginliğine sahip uygulamalarla doludur. Bunların yanısıra uygulamasından vazgeçilmiş ancak sözlü ya da maddi kültürümüzde izleri bulunan bazı adetlerinde yok olmakla var olmak arasında kaldığı görülmektedir. Bu adetler en azından literatüre geçirilmeyi ve kültür hazinemizde yer edinebilmeyi haketmektedirler. Bu adetlerden biri Gaziantep ve Malatya bölgesindeki köylerde hafızalarda kısmen muhafaza edilebilen; “gelin habercisi / çengel” olarak adlandırılan bir unsurdur. Elimizde örneği bulunan Çengel; Türk mitolojisinin ana karakterlerinden biri olan -kadınların ve çocukların koruyucusu- “Umay Ana”, olgusu üzerine yoğunlaşmaktadır. Türk inanç sistemine göre şekillenen evren tasarımı, dokuma, nakış, deniz kabukları, sedef düğmeler ve boncuk işleme gibi detaylarla hem geleneksel el sanatlarımıza ışık tutan hem de tasarım sektörüne ilham verici nitelikte olan bir kültür ögemizdir. Gelin tarafından genç bir çocuk bu haberciyi kafileden önce damat tarafına götürmekte ve gelini bekleyenler gelin alayının yola çıkmış olduğunu bu sayede anlamaktadır. Gelinin damadın evine gelmesinden sonra da kadınlar gelinin çeyizini, özellikle de Çengel’i görmek istemektedir. Çengel’in üzerinde bulunan malzemelerin ve uygulamaların niteliği gelinin ailesinin ekonomik durumunu ve gelinin becerisini göstermektedir. Düğünden sonra da bu Çengel, yeni gelin evinin en nadide köşesinde nazarlık olarak asılı tutulmaktadır.
Deciphering the Nature of Caffeic Acid to Inhibit the HSA Aggregation Induced by Glyoxal
Authors: Bhat Waseem Feeroze , Ahmed Azaj , Abbass Shabeena , Afsar Mohammad , Bano Bilqees , Masood Akbar
Published: January 2020

Background:

Under certain circumstances, the path for protein folding deviates and
attains an alternative path forming misfolded states, which are the key precursors for protein
aggregation. Protein aggregation is associated with variety of diseases and leads to the cytotoxicity.
These protein aggregate related diseases have been untreated so far. However, extensive attempts
have been applied to develop anti-aggregating agents as possible approaches to overcome protein
aggregation. Different types of substances have been reported to halt or decrease the formation of
ordered protein aggregates both in vitro and in vivo, such as polyphenols and metal ions.

Objective:

In the present study the in vitro aggregation of human serum albumin (HSA) by using a
reactive dicarbonyl glyoxal has been investigated, simultaneously an attempt has been done to
inhibit the glyoxal (GO) induced aggregation of (HSA) by caffeic acid (CA).

Methods:

Different methods have been employed to investigate the process, fluorescence
spectroscopy, circular dichroism, cango red binding assay, thioflavin T dye binding, turbidimetric
analysis, docking study and transmission electron microscopy.

Results:

Results have shown that elevated concentration of GO forms aggregates of HSA, and the
activity of CA suggested the possibility of inhibiting the HSA aggregation at higher concentrations,
and this compound was found to have an anti-aggregation property.

Conclusion:

The present study explained that micro molar concentrations of CA inhibits the
aggregation of HSA and showed pronounced anti-aggregation effect at increasing concentrations in
the presence of GO which is elevated in diabetic and hyperglycaemia conditions.
Renin-Angiotensin-Aldosterone System and Migraine: A Systematic Review of Human Studies
Authors: Sassi Karina Lúcia Moreira , Martins Laís Bhering , de Miranda Aline Silva , Teixeira Antonio Lucio
Published: January 2020

Migraine is a common neurologic condition marked by recurrent episodes of headache.
Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms.
The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential
pharmacological target for migraine treatment. We carried out a systematic review of the studies
evaluating the involvement of RAS in patients with migraine. There is evidence from genetic
studies exploring the relation between migraine and RAS-related genes and from clinical trials
evaluating the efficacy of Angiotensin II Type 1 (AT1) receptor antagonists and angiotensin
converting enzyme inhibitors in migraine prophylaxis. RAS seems to play a role in the
pathophysiology of migraine, but more direct evidence is still missing.
In Silico Elucidation of the Plausible Inhibitory Potential of Withaferin A of Withania Somnifera Medicinal Herb Against Breast Cancer Targeting Estrogen Receptor
Authors: Ali Mohammad A. , Farah Mohammad Abul , Al-Anazi Khalid M. , Basha Syed H. , Bai Fang , Lee Joongku , Al-Hemaid Fahad M.A. , Mahmoud Ahmed H. , Hailan Waleed A.Q.
Published: January 2020

Background:

Estrogen Receptors (ER) are members of the nuclear intracellular receptors
family. ER once activated by estrogen, it binds to DNA via translocating into the nucleus and regulates
the activity of various genes. Withaferin A (WA) - an active compound of a medicinal plant Withania
somnifera was reported to be a very effective anti-cancer agent and some of the recent studies has
demonstrated that WA is capable of arresting the development of breast cancer via targeting estrogen
receptor.

Objective:

The present study is aimed at understanding the molecular level interactions of ER and Tamoxifen
in comparison to Withaferin A using In-silico approaches with emphasis on Withaferin A
binding capability with ER in presence of point mutations which are causing de novo drug resistance to
existing drugs like Tamoxifen.

Methods:

Molecular modeling and docking studies were performed for the Tamoxifen and Withaferin
A with the Estrogen receptor. Molecular docking simulations of estrogen receptor in complex with
Tamoxifen and Withaferin A were also performed.

Results:

Amino acid residues, Glu353, Arg394 and Leu387 was observed as crucial for binding and
stabilizing the protein-ligand complex in case of Tamoxifen and Withaferin-A. The potential of
Withaferin A to overcome the drug resistance caused by the mutations in estrogen receptor to the existing
drugs such as Tamoxifen was demonstrated.

Conclusion:

In-silico analysis has elucidated the binding mode and molecular level interactions which
are expected to be of great help in further optimizing Withaferin A or design / discovery of future
breast cancer inhibitors targeting estrogen receptor.
A Comparative Review on Current and Future Drug Targets Against Bacteria & Malaria
Authors: Rout Usha K. , Sanket A.S. , Sisodia Brijesh S. , Mohapatra Pradyumna K. , Pati Sanghamitra , Kant Rajni , Dwivedi Gaurav R.
Published: January 2020

Long before the discovery of drugs like ‘antibiotic and anti-parasitic drugs’, the infectious
diseases caused by pathogenic bacteria and parasites remain as one of the major causes of morbidity
and mortality in developing and underdeveloped countries. The phenomenon by which the organism
exerts resistance against two or more structurally unrelated drugs is called multidrug resistance
(MDR) and its emergence has further complicated the treatment scenario of infectious diseases. Resistance
towards the available set of treatment options and poor pipeline of novel drug development
puts an alarming situation. A universal goal in the post-genomic era is to identify novel targets/drugs
for various life-threatening diseases caused by such pathogens. This review is conceptualized in the
backdrop of drug resistance in two major pathogens i.e. “Pseudomonas aeruginosa” and “Plasmodium
falciparum”. In this review, the available targets and key mechanisms of resistance of these pathogens
have been discussed in detail. An attempt has also been made to analyze the common drug targets of
bacteria and malaria parasite to overcome the current drug resistance scenario. The solution is also hypothesized
in terms of a present pipeline of drugs and efforts made by scientific community.
Gelatin and Glycerine-Based Bioadhesive Vaginal Hydrogel
Authors: Cassano Roberta , Curcio Federica , Mandracchia Delia , Trapani Adriana , Trombino Sonia
Published: January 2020

Aim:

The work’s aim was the preparation and characterization of a hydrogel based on gelatin
and glycerine, useful for site-specific release of benzydamine, an anti-inflammatory drug, able to attenuate
the inflammatory process typical of the vaginal infection.

Objective:

The obtained hydrogel has been characterized by Electronic Scanning Microscopy (SEM)
and Differential Scanning Calorimetry (DSC). In addition, due to the precursor properties, the hydrogel
exhibits a relevant mucoadhesive activity.

Methods:

The swelling degree was evaluated at two different pHs and at defined time intervals. In particular,
phosphate buffers were used at pH 6.6, in order to mimic the typical conditions of infectious
diseases at the vaginal level, particularly for HIV-seropositive pregnant women, and pH 4.6, to simulate
the physiological environment.

Results:

The obtained results revealed that the hydrogel swells up well at both pHs.

Conclusion:

Release studies conducted at both pathological and physiological pHs have shown that
benzydamine is released at the level of the vaginal mucosa in a slow and gradual manner. These data
support the hypothesis of the hydrogel use for the site-specific release of benzydamine in the vaginal
mucosa.
A Computational Study of the Conformational Behavior of 2,5-Dimethyl- 1,4-dithiane-2,5-diol and Analogous S and Se: DFT and NBO Study
Authors: Danaie Elmira , Masoudi Shiva , Masnabadi Nasrin
Published: January 2020

Conformational behaviors of 2,5-dimethyl-1,4-dithiane-2,5-diol (compound 1), 2,5- dimethyl-1,4-dithiane-2,5-dithiol (compound 2) and 2,5-dimethyl-1,4-dithiane-2,5-diselenol (compound 3) were investigated by the B3LYP/6-311+G **, the M06-2X/aug-ccpvdz levels of theory and natural bond orbital NBO analysis. The structures and the structural parameters of the mentioned molecules were optimized by the B3LYP and the M06-2X methods. We assessed the roles and contributions of the effective factors in the conformational properties of the mentioned compounds by means of the B3LYP and M06-2X levels of theory and the NBO interpretations. The stereoelectronic effects of the mentioned molecules were studied using the NBO analysis. The results showed that the stereoelectronic effects were in favor of the (ax,ax) conformers (the most stable conformations), from compound 1 to compound 3; therefore, these effects have impacts on the conformational properties of compounds 1-3, and stabilization energies associated with LP2X→ σ*S1-C2 electron delocalization, where [X= O, S, and Se], for 1-ax, ax conformer has the greatest value between all of the other conformers. Therefore, according to the calculated thermodynamic parameters, the stability of the 1-ax, ax compound was justified by the presence of LP2X→σ*S1-C2 electron delocalization. A molecular orbital explanation was conducted to investigate the correlations between the linear combinations of natural bond orbitals in the HOMOs, LUMOs and the molecular reactivity parameters. There is a direct relationship between the stereoelectronic effects, molecular reactivity and thermodynamic parameters of compounds 1 to 3 as the harder ax, ax conformations with the greater stereoelectronic effects and ΔG(eq-ax) values are more stable than their corresponding eq, eq conformers. Besides frontier molecular orbitals (FMOs), mapped molecular electrostatic potential (MEP) surfaces of conformations of compounds 1 to 3 were investigated.
Preliminary Analysis of Anti-proliferative, Apoptotic, and Anti-migratory Effects llw-3-6 in Skov-3 Ovarian Cystadenocarcinoma Cell Line
Authors: Gregory-Bass Rosalind , Winfield Leyte L.
Published: January 2020

Background:

Ovarian cancer and ovarian related diseases affect reproductive health.
Therapeutic molecules are needed to improve treatment outcomes and overcome drug resistance.
The benzimidazole-based sulphonamide LLW-3-6 has both anti-apoptotic and anti-proliferative
effects when used to treat prostate, breast, and brain cancer cells.

Objective:

The study described herein evaluates the anti-proliferative and anti-migratory effects of
LLW-3-6 in SKOV-3 ovarian cystadenocarcinoma cell line.

Methods:

Studies were conducted using SKOV-3 cells treated with LLW-3-6. The cell line was
propagated and proliferative activity was evaluated by hemocytometric and MTT colorimetric
assays. Cellular apoptosis was assessed using caspase-3 spectrophotometric analysis. Lastly, a
scratch wound assay was conducted at several concentrations and time points to assess the effect of
LLW-3-6 on migration.

Results & Conclusion:

Proliferative studies suggest, SKOV-3 cells exposed to LLW-3-6 in culture
resulted in decreased growth and proliferation of cells in a time and dose-dependent manner. The
apoptotic effect of this agent was noted with the confirmed presence of Caspase-3 in a dose and
time-dependent manner as well. Preliminary studies also suggest an anti-migratory effect of LLW-3-
6, confirmed by scratch wound analysis.

Conclusion:

LLW-3-6 is potentially a chemotherapeutic option for decreasing proliferation and
inducing apoptosis in ovarian carcinomas. Additional biological analysis are ongoing to further
assess the utility of the molecule and its mechanism of action.
A Concise Review on Mesenchymal Stem Cells for Tissue Engineering with a Perspective on Ocular Surface Regeneration
Authors: Salih Mohamed , Shaharuddin Bakiah , Abdelrazeg Samar
Published: January 2020

Organ and tissue transplantation are limited by the scarcity of donated organs or tissue
sources. The success of transplantation is limited by the risk of disease transmission and immunological-
related rejection. There is a need for new strategies and innovative solutions to make transplantation
readily available, safer and with less complications to increase the success rates. Accelerating progress
in stem cell biology and biomaterials development have pushed tissue and organ engineering to a
higher level. Among stem cells repertoire, Mesenchymal Stem Cells (MSC) are gaining interest and
recognized as a cell population of choice. There is accumulating evidence that MSC growth factors, its
soluble and insoluble proteins are involved in several key signaling pathways to promote tissue development,
cellular differentiation and regeneration. MSC as multipotent non-hematopoietic cells with
paracrine factors is advantageous for regenerative therapies. In this review, we discussed and summarized
the important features of MSC including its immunomodulatory properties, mechanism of homing
in the direction of tissue injury, licensing of MSC and the role of MSC soluble factors in cell-free
therapy. Special consideration is highlighted on the rapidly growing research interest on the roles of
MSC in ocular surface regeneration.
Effects of Electrical Stimulation on Stem Cells
Authors: Heng Wang , Bhavsar Mit , Han Zhihua , Barker John H.
Published: January 2020

Recent interest in developing new regenerative medicine- and tissue engineering-based treatments has motivated researchers to develop strategies for manipulating stem cells to optimize outcomes in these potentially, game-changing treatments. Cells communicate with each other, and with their surrounding tissues and organs via electrochemical signals. These signals originate from ions passing back and forth through cell membranes and play a key role in regulating cell function during embryonic development, healing, and regeneration. To study the effects of electrical signals on cell function, investigators have exposed cells to exogenous electrical stimulation and have been able to increase, decrease and entirely block cell proliferation, differentiation, migration, alignment, and adherence to scaffold materials. In this review, we discuss research focused on the use of electrical stimulation to manipulate stem cell function with a focus on its incorporation in tissue engineering-based treatments.
Characterization of Antimicrobial Resistance Patterns of Klebsiella pneumoniae Isolates Obtained from Wound Infections
Authors: Ghanavati Roya , Kazemian Hossein , Asadollahi Parisa , Heidari Hamid , Irajian Gholamreza , Navab-Moghadam Fatemeh , Razavi Shabnam
Published: January 2020

Background:

Multidrug resistance among ESBL producing isolates has limited the administration
of proper antibiotics. It is, therefore, important to monitor the resistance patterns of
Klebsiella pneumoniae isolates and provide infection control strategies to prevent nosocomial outbreaks.
This study was aimed to determine antimicrobial resistance patterns of K. pneumoniae isolates
obtained from wound infections of patients in Tehran, Iran.

Methods:

A total of 102 K. pneumoniae isolates were obtained from wound infections of patients
in Tehran, Iran. The production of phenotypic ESBL and carbapenemase was assessed using the
double-disc synergy test (DDST) and modified Hodge test (MHT), respectively. PCR was performed
for the detection of ESBL, carbapenemase, quinolone and aminoglycoside resistance genes.

Results:

Forty-six (45.1%) and 23 (22.5%) isolates, out of the 102 isolates, were phenotypically detected
as ESBL and carbapenemase producers, respectively. The PCR results showed that 80/102
(78.4%) and 51/102 (50%) isolates possessed at least one of the assessed ESBL and carbapenemase
genes, respectively. Quinolone resistance determinants (QRDs) and aac(6')-Ib genes were
found amongst 50 (49%) and 67 (65.7%) isolates, respectively. Four isolates carried blaTEM, blaSHV,
blaCTX-M, qnrB, qnrS and aac(6’)-Ib genes, simultaneously.

Conclusion:

Due to the presence of multiple resistance genes among some K. pneumoniae strains,
antibiotic agents should be used with caution to preserve their efficacy in case of life-threatening infections.
Neovascular Age-Related Macular Degeneration and its Association with Alzheimer’s Disease
Authors: Papadopoulos Zois
Published: January 2020

:

In developed countries, people of advanced age go permanently blind most often due to
age-related macular degeneration, while at the global level, this disease is the third major cause of
blindness, after cataract and glaucoma, according to the World Health Organisation. The number of
individuals believed to suffer from the disease throughout the world has been approximated at 50
million. Age-related macular degeneration is classified as non-neovascular (dry, non-exudative)
and neovascular (wet, exudative). The exudative form is less common than the non-exudative as it
accounts for approximately 10 percent of the cases of the disease. However, it can be much more
aggressive and could result in a rapid and severe loss of central vision. Similarly, with age-related
macular degeneration, Alzheimer’s disease is a late-onset, neurodegenerative disease affecting millions
of people worldwide. Both of them are associated with age and share several features, including
the presence of abnormal extracellular deposits associated with neuronal degeneration, drusen,
and plaques, respectively. The present review article highlights the pathogenesis, clinical features,
and imaging modalities used for the diagnosis of neovascular age-related macular degeneration. A
thorough overview of the effectiveness of anti-VEGF agents as well as of other treatment modalities
that have either lost favour or, are rarely used, is provided in detail. Additionally, the common
histologic, immunologic, and pathogenetic features of Alzheimer’s disease and age-related macular
degeneration are discussed in depth.
The Effect of Grain Size on Microwave Interaction of Magnetite Concentrate Mixed with Carbonized Biomass Waste
Authors: Öztürk Elif Aranci , Boyrazli Mustafa , Turan Mehmet Deniz , Erdemoğlu Murat
Published: January 2020

Aims:

In this study, microwave interaction of magnetite ore concentrate which
was mixed with carbonized biomass waste and divided into different grain sizes, was
studied.

Materials and Methods:

The mixture consisting of magnetite concentrate and carbonized
product was pelletized by the addition of molasses and jelly as binders. The pellets prepared
with various particle size powders were subjected to microwave treatment at different
times.

Results:

emperature of the pellet produced with powders between -212 +150 μm grain
sizes and -45 μm were measured as 837.5°C at 304th second and 945.9°C at 210th second
respectively.

Conclusion:

Although there was a large temperature difference between the core and the
surface of the pellet, a high degree of metallization was observed in these samples.
Amelioration of Dementia and Antioxidant Activity of Holarrhena antidysenterica Bark in Mice
Authors: Kaur Jasleen , Kumar Manish , Bansal Nitin
Published: January 2020

Background:

Holarrhena antidysenterica is a deciduous shrub/small-tree having
bioactive alkaloids such as conessine, known for astringent, antidysenteric, anthelmintic,
stomachic, febrifugal, tonic and anti-acetylcholinesterase properties. Dementia is an
age related neurodegenerative syndrome with Alzheimer’s disease, the most prominent
cause, which has limited therapeutic options available.

Objective:

The present study aimed to explore the potential benefits of H. antidysenterica
in the management of dementia.

Method:

Aqueous and methanol extracts of powdered bark of H. antidysenterica were
prepared, concentrated and conessine concentration was estimated using High Performance
Thin Layer Chromatography (HPTLC) method. Methanol extract of H. antidysenterica
(MEHA) was administered at doses 100, 150 and 200 mg/kg (i.p.) to mice (20-30 g) for 14
consecutive days. Scopolamine (Scop; 1 mg/kg) and Lipopolysaccharide (LPS; 250 μg/kg)
were given (i.p.) before behavioural trials to induce memory impairment. Learning and
memory functions in mice were evaluated. Brain acetylcholinesterase (AChE) activity,
glutathione (GSH) and Thiobarbituric Acid Reactive substances (TBARS) levels were estimated.

Results:

MEHA markedly increased learning and memory of mice. Scop or LPS caused a
significant decline of spatial memory in mice, which was attenuated by MEHA (100 and
200 mg/kg). Furthermore, LPS conspicuously increased the lipid peroxidation and compromised
antioxidant levels in mice brains. MEHA pre-treatment significantly increased
GSH content and decreased TBARS level in the brain of LPS administered mice. AChE
activity was significantly decreased by MEHA in the brain of mice.

Conclusion:

The methanol extract of H. antidysenterica may prove to be a useful remedy
in the management of dementia.
K-means Clustering-based Radio Neutron Star Pulsar Emission Mechanism
Authors: Shrimali Shubham , Pandey Amritanshu , Chowdhary Chiranji L.
Published: January 2020

Aim:

The aim of this paper is to work on K-means clustering-based radio neutron star
pulsar emission mechanism.

Background:

The pulsars are a rare type of neutron stars that produce radio rays. Such types of
rays are detectable on earth and have attracted scientists because of their concern with space-time,
interstellar medium, and states of matter. During the rotation of pulsar rays, rays are emitted in the
whole sky and after crossing the threshold value, the pattern of radio emission broadband is detected.
As rotation speed of pulsar increases then accordingly the types of the patterns are produced
periodically. Every pulsar emits different patterns that are a little bit different from each
other which fully depends on its rotation. The detected signals are known as a candidates. It can be
determined by the length of observation and it is average of all the rotations of the pulsar.

Objective:

The main objectives of this radio neutron star pulsar emission mechanism are: (a) Decision
Tree Classifier (2) K-means Clustering (3) Neural Networks.

Methods:

The Pulsar Emission Data was broken down into two sets of data: Training Data and
Testing Data. The Training Data is used to train the Decision Tree, the algorithm, K-means clustering
and Neural Networks to allow it to identify, which attributes (Training Labels) are useful for
identification of Neutron Pulsar Emissions.

Results:

The analysis used multiple machine learning algorithms. It was concluded that using neural
networks is the best possible method to detect pulsar emissions from neutron stars. The best result
achieved was 98% using Neural Networks.

Conclusion:

There are so many benefits of pulsar rays in different technologies. Earth can detect
pulsar ray from low orbit. Earth can completely absorb X-ray in the atmosphere and due to this
reason we can say that the wavelength is limited to those who do not have an atmosphere like
space. According to our result, it can be concluded that the algorithm can be successfully used for
detecting the pulsar signals.
An Intelligent Ranking Model for Multi-Criteria Decision Making Using Fuzzy Matrix Method
Authors: Dahiya Naveen , Sangwan Pardeep
Published: January 2020

Background:

In the daily life, one may encounter several problems whose solution is based on the
consideration of several criteria altogether. To generate a solution for such problems is in fact a complex task. If
one generates a solution, then there is no guarantee that the solution is optimal. It is really challenging to take
into account all the criteria at the same time and generate a solution that is optimal. Several techniques have been
proposed to solve multi-criteria decision making problems.

Methods:

In this paper, we propose an intelligent solution to multi criteria decision making problem by means
of fuzzy aggregation using matrix method. The proposed method finds application in solving such problems
where the criteria are defined in qualitative form (fuzzy linguistic variables) rather than in quantitative form
(crisp). A novel application of the proposed approach to rank the employees in an organization is presented in
the paper.

Results:

The proposed method is empirically validated by applying it to find the best employee in a institute of
repute. Data collection is done in real time to prove the utilization of proposed approach in a efficient manner.

Conclusion:

The results obtained after application of proposed method to rank the employees are realistic as it
takes into consideration the ambiguity involved in human thought process.
Pengaruh Perubahan Ketebalan Terhadap Tegangan Ambang Dan Waktu Tanggap Pada Sel Twisted Nematic (Halaman 21 s.d. 25)
Authors: Setyo Adhidhuto Linus , Yusuf Yusril
Published: January 2020

Telah dilakukan penelitian pengaruh ketebalan sel kristal cair terhadap tegangan ambang serta waktu tanggap untuk sel Twisted Nematic (TN). Digunakan 4 sel TN dengan ketebalan berbeda 50 μm, 100 μm, 150 μm, dan 200 μm, yang masing-masing diisi dengan kristal cair jenis 4-n-pentyl-4’-cyanobiphenyl (5CB). Ketebalan sel tidak mempengaruhi tegangan ambang, namun mempengaruhi waktu tanggap. Waktu tanggap yang diteliti ada 2 jenis yaitu rise time dan fall time. Semakin tebal sel TN, maka semakin besar pula rise time dan fall time.
Kajian Magnetoresistansi pada Nanopartikel Magnetite (Fe3o4) yang Dienkapsulasi dengan Polyethylene Glycole (PEG) dan Biomaterial dengan Sensor Lapisan Tipis Co/Cu Multilayer Berbasis Giant Magnetoresistance (GMR) (Halaman 13 s.d. 19)
Authors: Artauli Hasibuan1 Ferawati , Pardede Indra , Suharyadi Edi
Published: January 2020

Telah dilakukan kajian magnetoresistansi (MR) pada nanopartikel magnetit (Fe3O4) yang dienkapsulasi dengan poliethilen glikol (PEG)-4000 dan biomolekul menggunakan sensor lapisan tipis berbasis giant magnetoresistance (GMR). Lapisan tipis yang digunakan adalah Si/Cr(5nm)/[Co(1,5nm)/Cu(x)]20/Cr(5nm) multilayer (x = 0,8; 0,9; dan 1,0 nm).  Fenomena GMR dipengaruhi oleh variasi ketebalan lapisan tipis dan pelapisan nanopartikel Fe3O4 yang dienkapsulasi dengan PEG dan penambahan biomolekul yang mengganggu mobilitas momen magnetik material. Resistansi pada ketebalan lapisan tipis Cu 0,8; 0,9; dan 1,0 nm ketika H=0  masing-masing 3,7; 3,5; dan 2,7 Ohm dan ketika H=599,7 G masing-masing 3,5; 3,2; dan 2,3 Ohm. Nilai MR ketika lapisan tipis dilapisi nanopartikel Fe3O4, Fe3O4 yang dienkapsulasi dengan PEG, dan Fe3O4 yang dienkapsulasi dengan PEG dan penambahan biomolekul masing-masing mengalami perubahan yang berbeda. Perubahan nilai MR pada lapisan tipis multilayer sebelum dan setelah pelapisan nanopartikel menunjukkan bahwa lapisan tipis Co/Cu multilayer dapat diaplikasikan sebagai sensor medan magnet dan potensial sebagai biosensor.
Implementasi Kurikulum 2013: MOODLE (Modular Object Oriented Dynamic Learning Environment) dalam Pembelajaran Fisika melalui Lembar Kerja Siswa pada Materi Optik di SMA (Halaman 54 s.d. 58)
Authors: Joyo Sampurno Pandu , Maulidiyah Rizky , Zuliana Puspitaningrum Hidayah
Published: January 2020

Perkembangan teknologi menuntut dunia pendidikan terus meningkatkan mutu penggunaan teknologi informasi dalam pembelajaran. Media pembelajaran berbasis teknologi komputer seperti moodle merupakanmedia belajar untuk diaplikasikan sesuai tuntutan kurikulum 2013. Moodle merupakan model tempat belajar dinamis berorientasi objek yang berbasis web. Pengaplikasian moodle dapat membantu siswa mendapatkan tambahan pengetahuan berupa: (1) Materi pembelajaran optik di upload melalui fitur moodle; (2) Lembar Kerja Siswa (LKS) yang inovatif dan meningkatkan kemandirian siswa sesuai tuntutan kurikulum 2013.Jenis penelitian yang digunakan adalah Research and Development (R & D), yaitu penelitian dan pengembangan.Metode penelitian dan pengembangan adalah metode penelitian yang digunakan untuk menghasilkan produk tertentu, dan menguji keefektivan produk tersebut. Tujuan dari penelitian adalah mengembangkan Lembar Kerja Siswa (LKS) pada pembelajaran fisika pada materi optik melalui moodle berbasis e-learning sebagai upaya inovatif untuk mendukung implementasi kurikulum 2013.
Pengembangan Pendingin Termoakustik dengan Menggunakan Penukar Kalor Tambahan dalam Resonator (Halaman 59 s.d. 63)
Authors: P. Asmara , A. Pebriarti , I. Setiawan , Bambang S.U. Agung
Published: January 2020

Telah dilakukan penelitian piranti termoakustik dengan mengamati pengaruh heat exchanger menggunakan berbagai debit cairan dan jenis cairan pada penurunan suhu tandon panas dan tandon dingin.   Hasil yang diperoleh sebagai cairan terbaik yang digunakan adalah air, disamping mudah didapat juga tidak menimbulkan korosi pada pipa tembaga sehingga aliran cairan dalam pipa berjalan dengan lancar dan diperoleh penurunan suhu pada tandon panas sebesar 5,5 °C serta 1,3 °C pada tandon dingin. Adapun penurunan suhu optimum tandon panas sebesar 5,4 °C dan tandon dingin sebesar 1,8 °Cyang terjadi pada saat pipa tembaga dialiri air dengan debit (2,47 ± 0,01) mL/s. Terlihat dengan adanya penggunaan heat exchanger berupa pipa tembaga yang dialiri cairan menyebabkan tandon panas mengalami penurunan suhu sehingga tandon panas belum jenuh dan pemompaan kalor dari tandon dingin ke tandon panas tetap stabil (dingin) yang berarti kinerja sistem meningkat.
Aplikasi Sensor Smartphone dalam Eksperimen Penentuan Percepatan Gravitasi (Halaman 10 s.d. 13)
Authors: Suciarahmat Aan , Pramudya Yudhiakto
Published: January 2020

Telah dilakukan penelitian untuk menentukan nilai percepatan gravitasi menggunakan aplikasi sensor Smartphone berbasis Android. Analisis matematis dilakukan menggunakan teknik rata-rata dari data yang terekam oleh aplikasi sensor Accelerometer.  Analisis data smartphone ini dibandingkan dengan data yang diperoleh dari video analisis program Logger Pro, dan untuk membantu perhitungan dilakukan analisis dengan pendekatan Regresi Linier. Dari hasil analisis data smartphone, diperoleh nilai percepatan gravitasi adalah (9,7245±0,005) m/s2.
Karakterisasi Sifat Optik Lapisan Tipis ZnO doping Al yang di Deposisi diatas Kaca dengan Metode Sol-Gel Teknik Spray-Coating (Halaman 38 s.d. 40)
Authors: Durri Sufwan , Sutanto Heri
Published: January 2020

Telah dilakukan sintesis dan deposisi ZnO doping Al mengunakan metode sol-gel teknik spray coating. Lapisan tipis ZnO dengan variasi doping Al diuji menggunakan UV-Vis Spestroscopy. Pengaruh penambahan doping Al pada lapisan tipis ZnO mempengaruhi pergeseran (Shift Blue) pada panjang gelombang 360 nm–380 nm, nilai transmitansi lapisan tipis pada sinar tampak dengan rentang 64%-96% dan lapisan tipis ZnO tanpa doping nilai transmitansi pada sinar tampak rata-rata lebih dari 90%. Energi celah pita optik Eg meningkat seiring dengan meningkatnya konsentrasi doping dari 0%, 2% dan 4% dengan nilai Eg 3,102 3,115 eV dan 3,118 eV.
Analisis Akord Dmayor pada Alat Musik Gitar Acoustik (Halaman 77 s.d. 81)
Authors: Anwar Khairil , Isnaini M. , Sekar Utami Linda
Published: January 2020

Bunyi alat musik gitar merupakan salah satu gejala fisika yang menarik untuk dikaji, karena menghasilkan nada kompleks yang merupakan superposisi dari banyak nada murni (harmonik). Akord merupakan prinsip utama dalam memainkan alat musik gitar, salah satunya akord Dmayor yang merupakan superposisi nada A, Fis, dan D secara bersamaan. Secara fisis, kita belum mengetahui mengapa akord Dmayor tersusun atas tiga nada tersebut dan belum terbukti secara konsep fisika apakah benar pernyataan tersebut. Oleh karena itu makalah ini bertujuan untuk menyelidiki dan menganalisis fenomena akord Dmayor tersebut berdasarkan frekuensi harmonik yang terbentuk. Metode yang digunakan adalah eksperimen laboratorium berbasis teknologi komputer dengan bantuan perangkat lunak MacScope II dan Matlab. Data direkam dan dianalisis dengan metode matematika FFT (Fast Fourier Transform) untuk menentukan frekuensi harmonik nada-nada penyusun akord Dmayor. Berdasarkan hasil analisis diperoleh bahwa Nada Fis (F#4) memiliki frekuensi dasar (harmonik pertama) hingga ke-empat, Nada D4 muncul frekuensi harmonik pertama hingga ke lima, Nada A3 diperoleh frekuensi harmonik berturut-turut hingga harmonic ke lima, sedangkan frekuensi harmonik nada D3diperoleh berturut-turut hingga harmonik ke lima, dan akord Dmayor hanya muncul dua frekuensi secara harmonik, dimana frekuensi dasar dan frekuensi atas satu (harmonik ke dua) berturut-turut diperoleh penyimpangan terhadap frekuensi acuan sebesar 0,07%, dan 0,24%. Jadi, berdasarkan hasil analisis data disimpulkan bahwa akord Dmayor tersusun atas nada-nada D3, A2, D4, dan Fis, hal ini dikarenakan semuanya mengandung frekuensi harmonik yang sesuai dengan frekuensi bunyi akord Dmayor.