bluuebunny/crossref_metadata_2025 huggingface dataset:
La caravana migrante en las noticias de La Jornada y The New York Times
Authors: Mukhortikova Tatiana
Published: July 2022

Este artículo analiza los encuadres aplicados en el tratamiento de la caravana migrante 2018 en las versiones digitales del diario mexicano La Jornada y en el periódico estadounidense The New York Times, que representan dos países, uno de los cuales es el destino de los inmigrantes y el otro es un país de tránsito. Los resultados del estudio revelan significativas diferencias en la manifestación y la distribución de los encuadres. Si el diario estadounidense se centró en las reacciones y consecuencias a nivel político, geopolítico o económico, manteniendo un tono distante, el periódico mexicano prestó mayor atención a la gestión de la caravana y a las causas de los desplazamientos, manteniendo el foco en las historias personales.
Semiótica en Chile. Cartografía 1990-2015
Authors: Ossandón Buljevic Carlos
Published: July 2022

Reseña del libro de Elizabeth Parra, Sandra Meza y Gabriel Guajardo. (2021). Semiótica en Chile. Cartografía 1990-2015. Santiago de Chile: Ediciones Escaparate. 311 páginas. ISBN 978-956-394-055-8.
Evaluation of the effect of using different doses of levothyroxine on some biochemical parameters in hypothyriod patients
Authors: Al-Nasiri Maryam Thaer Saadi , Alsamarai Abdulsalam Tawfeeq Salih
Published: July 2022

The current study included the collection of ninety serum samples to evaluate the effect of using different doses of levothyroxine on some biochemical parameters in patients with thyroid disorders. Samples were collected for the period between 15/9/21 to 10/1/2022. Sixty samples were taken from patients with hypothyroidism(G1) who subdivided into two subgroups; 26 of them took the levothyroxine dose of 200 µg/day (G2), and 34 of them took the levothyroxine dose of 100 µg/day (G3), and 30 samples were taken as a control group, their ages ranged between (46-60) years. The level of hepcidin hormone and the activity of the alkaline phosphatase-ALP, Alanine amino transferase-ALT, and Aspartate amino transferase-AST enzymes were evaluated in the serum of hypothyroid patients and healthy subjects as a control group. The results showed that the level of hepcidin hormone significantly (P≤0.05) elevated in serum of patients in group (G3) than the control group and the rest of the other groups. The results showed a significant increase(P≤0.05) in the activity of aspartate aminotransferase enzyme, alanine transferase enzyme and alkaline phosphatase enzyme activities in the serum of patients with hypothyroidism compared to the control group.
role of digital technology in visual display methods in natural history museums around the world
Authors: Mahmod Waad Addnan
Published: July 2022

The current research, entitled (The Role of Digital Technology in Display Methods in Natural History Museums around the world), presents the discovery and knowledge of the importance of employing this in showing different aesthetics and techniques.Thus, the researcher presented the goal of the research in chapter one in identifying the role of technology in perceiving the variables that occur in the visual display methods of natural history museums.As for chapter two, the researcher divided it into two topics, the first one titled: Transformers of Digital Technology in Museum Display Methods, in which the researcher tracks the methods presented by digitals in contrast to the methods of museum presentation, whether in form, presenting information, or stimulating the senses of the recipient, while topic two bears the title: The Museum of Natural History between Digital technology and visual display methods, and the researcher tracks natural history museums and their investment in technology transformations in building a different display space from the above, while chapter presented models for natural history museums in which the role of digital technology in visual presentations was made, while chapter four reached the results and conclusions, including (there are two results, after which recommendations and suggestions are presented.
Serological study of human Cytomegalovirus spread among aborted women in Najaf Governorate and assessment of MCP-1 chemokine effect on the virus
Authors: Al-Kinani Roaa Mohammed Hussein , Al-Kaabi Azhar Jasim
Published: July 2022

This study aims to determine the prevalence of IgM, IgG, anti-Human cytomegalovirus (HCMV) in Najaf women and determining the level of MCP-1 chemokine concentration and its role in the immune response. This study was conducted on 65 were suffering from HCMV infection and were referred to the women's consulting clinic and maternity halls in each of the Al-Zahra teaching hospital and Al-Manathira general hospital and 15 women as a control without any miscarriage, during the period from 6 April to 12 June, and these samples were chosen within the age range is between (18 to 40) years. HCMV IgM, IgG antibody tests were performed using Enzyme-Linked Immunosorbent Assay, and the result showed that the prevalence of IgG and IgM immunoglobulins in pregnant women with miscarriages according to the statistical analysis that there is a high significantly difference with a level ≤ P 0.05 in IgG and IgM concentration within different age groups of aborted women compared to the control treatment group of women.
Evaluation of tumor necrosis factor alpha and interlukine-11 in a sample of aborted women infected with human Cytomegalovirus
Authors: Al-Kinani Roaa Mohammed Hussein , Al-Kaabi Azhar Jasim
Published: July 2022

This study aimed to evaluate the immunological role of TNF-alpha and interlukine-11 for a sample of women infected with HCMV. 65 blood samples were collected from aborted women and 15 blood samples were collected from healthy non-aborted women (as a control group) during the period from 6 April to 12 June from reviews Al-Zahra teaching hospital and Al-Manathira general hospital in Najaf governorate. HCMV IgM, IgG antibody tests were performed by using Enzyme-Linked Immunosorbent Assay (ELISA- Human, Germany).The results showed that the prevalence of IgG and IgM immunoglobulins against HCMV in pregnant women with miscarriages according to the statistical analysis that there is a high significantly difference with a level ≤ P 0.05 in IgG and IgM concentration within different age groups of aborted women compared to the control treatment group of women.The samples under study were also tested to measure the level of TNF-α and IL-11 cytokines by using a quantitative technique the enzyme-linked immunosorbent assay as well, the results showed that there is a hight significant in the concentration of TNF-α protein in aborted women, which reached 8.24 ± 1.58 (pg/ml)., and this was significant at P ≤ 0.003 compared with the control group 5.51 ± 2.96(pg/ml).
Minimally invasive fixations in management of pilon fractures in adults
Authors: Shehata Ahmed Elsayed Abdelraouf , Mostafa Ibrahim Ahmed , Abdelmotaleb Mohamed Moawad
Published: July 2022

Background: Pilon fractures make up one percent of all breaks in the lower extremities and five to seven percent of all fractures of the tibia. Pilon fractures are caused by events with a lot of force like car accidents and falls from a high place, which put direct axial pressure on the tibial plafond and push it into the joint. The most common way to break a pilon is to fall from a high place. Even though there have been a lot of improvements in how these fractures are treated in the last few years, there is still a lot of disagreement about which treatment is best. Aim of the Work: The goal of this study is to look at both the effectiveness of minimally invasive fixations and the results of these types of fixations in treating pilon fractures in adults. Patients and Methods: This research was carried out between January 2021 and December 2021 at the hospitals affiliated with the Al-Azhar University, which are known as the Al-Hussien and Sayed Galal hospitals.
study regarding the interrelation between subclinical hypothyroidism & insulin resistance among PCOS women
Authors: Rosivari Pravallika Sudharani , Kalki Hymavathi , Deekala Ravi Sankar
Published: July 2022

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder (5-10%) in women of reproductive age. It is characterized by clinical and biochemical hyperandrogenism, menstrual irregularities, infertility and metabolic syndrome. Hypothyroidism is more common in PCOS. Subclinical hypothyroidism may aggravate insulin resistance. Objective: To find any relationship between subclinical hypothyroidism and Insulin resistance in PCOS patients. Materials and Methods: Study Design:  A hospital based cross sectional study, Study Subjects: PCOS cases fulfilling the inclusion and exclusion criteria, SAMPLE SIZE: 100 PCOS cases attending to Gynaecology OPD, Study Setting: Gynaecology OPD of a Medical College hospital, Study Duration: January 2015 to August 2016.  This included all PCOS patients, who had the criteria of Rotterdam for PCOS. Clinical examination, height, weight, BMI and lab data were measured including thyroid hormone and biochemical profile. Data were analysed by SPSS software version 21. Results: Out of 100 study subjects 52 were Euthyroid (TSH < 5) and 48 were SCH (TSH ≥ 5). Fasting serum Insulin, and HOMA IR were significantly elevated in SCH group compared to Euthyroid group (p = < 0.05.).
Deep learning approach to identify abnormalities in blood cell images
Authors: Jane F. Mary Magdalene , Sudha V. Pream , Soundarraj A. C.
Published: July 2022

Blood cell imaging provides crucial diagnostic information about a person's atypical problems. Due to their multi-level structures, Deep Learning models aid in extracting complicated insights from input images. The power of automatic feature extraction makes Convolutional Neural Networks (CNN) the most widely used deep learning approach for blood cell categorization. Blood cells are classified using a recurrent neural network (RNN), which captures long-term relationships between elements. The possibility of CNN-RNN-based models for blood cell image classification is investigated in this work. The results prove that CNN-LSTM based model outperforms in classifying the blood cell images with an accuracy of 92.1%.
Survey on optimization algorithms in speech processing
Authors: Manjutha M , Subashini P
Published: July 2022

Nature is a tremendous provenance of resolving hard and complex problems that exist in the field of computer science because it reveals a very diverse, robust, dynamic, and interesting phenomenon. It constantly finds the optimal solution to resolve its problem which accomplishes exact equity among its element. Nature-inspired algorithms are the heuristic high-level procedure that interprets nature to solve the optimization problem which popularized in the new era of computation. The main objective of this paper is to evaluate the modern technology and enhancement in the nature-inspired algorithm, especially in the application of speech processing, speech recognition, and speech feature selection problems. This paper presents broad collections of global optimization algorithms which have been successfully applied to generate recognition systems that are integrated with metaheuristic algorithms.
Morphological characteristics and genetic diversity of the Anadara antiquata distribution in Central Vietnam
Authors: Nguyen Thi Nhu Y , Tran Thi Kim Anh , Tran Quoc Dung , Tran Van Giang
Published: July 2022

Anadara antiquata belongs to the Mollusca phylum, class Bivalvia, distributed in the coastal areas of Vietnam, with high nutritional and economic value. This study focused on the morphological characteristics and genetic diversity of A. antiquata in six regions of central Vietnam (Da Nang, Quang Nam, Phu Yen, Nha Trang, Binh Thuan and Thanh Hoa). The analysis of morphology of A. antiquata had the following results: shell width (SW: 41.45 mm), shell length (SL: 22.54 mm), right shell height (HRV: 29.27 mm), height left sheath (Coach: 28.49 mm), ligament length (LL: 25.74 mm), right trochanteric cavity depth (UHR: 7.90 mm), left trochanteric space depth (UHL: 8, 33 mm), right case symmetry (SRV: 8.58 mm) and left case symmetry (SLV: 8.41 mm). The mean shell volume (SV) and shell cavity volume (DSWT) were 4.45 ml and 11.11 ml, respectively. The average dry peel weight was 11.17 g. Genetic diversity showed that the 8 random primers used to analyze DNA polymorphisms of 41 A. antiquata had 87 amplified polymorphic DNA bands.
An exploratory study to identify risk for reproductive tract infections among women in selected areas of Pune city with a view to develop self- instructional module
Authors: Bharam Dipali Laxman , Gadade Manisha Sanjay
Published: July 2022

An exploratory study to identify the risk for reproductive tract infection among women in selected areas of Pune city with a view to develop self-instructional module”. Objectives: To identify the risk for reproductive tract infection. 2. To find association between the findings with selected demographic variable. 3. To develop self-instructional module on reproductive tract infection. Material and Method: A quantitative research design used in this study. A study was conducted in selected areas of Pune city, India. Non- probability purposive sampling technique was used. Total 260 sample of married women were included in this study. Self- structure questionnaire was prepared to identify the risk for reproductive tract infection. The collected data were analyses by using descriptive, frequency and percentage statistics and logistic regression analysis. The chi-square is used to see the association between demographic variable and outcome variable of RTI. The self-instructional module was prepared on reproductive tract infection. Result: Data shown the majority of risk factor found i.e. Vaginal discharge 212(81%) followed by difficulty in micturition 128(49%) and itching over perinium 114(43%). Among 260 women 167 women are at high risk for developing the reproductive tract infection.
Factors affecting the level of learning satisfaction among first-year accounting students
Authors: Uvathi Uvathi , Zainol Arnee Zulia , Din Norkhairul Azlina , Aziz Asmawana , Mohamad Mafuzah
Published: July 2022

In particular, “this research investigates the elements that influence students' happiness with their learning experiences in business school and accounting.” Following “a series of focus group sessions involving 45 university students,” the results of which were used to build an instrument for measuring student learning satisfaction, there were factors of student satisfaction determined from 550 students' responses, with all criterion receiving good marks from the students who participated. In addition, “it was discovered that gender and major had an effect on the relationship between the seven factors and students' reported” happiness with their education.
Didactic strategy to promote logical-mathematical thinking in middle school students
Authors: Quijije-Castro Mercedes Berónica , Pinargote-Jiménez Joel Antonio
Published: July 2022

The research was based on investigating a didactic strategy that favors mathematical logical thinking to solve reasoning problems, through playful activities, which implies the incorporation of the game, so that the middle school students of the Ibarra Educational Unit # 2 of the Chone canton They will have quality learning. A diagnosis was made through field research, observing, and analyzing the difficulties encountered in mathematics; Topics from different authors were studied. The objective was to evaluate a didactic strategy to favor mathematical logical thinking, its quantitative approach and analytical methods were used - synthetic, inductive - deductive, statistical, surveys were applied to teachers, parents and observation sheet to teachers and students. The process of teaching mathematics requires learning that allows comprehensive problem solving that develops logical thinking, for which a didactic strategy such as playful activities is proposed, in which mental calculation is developed through a game guide. interactive. As a result, recreational activities were obtained as a didactic strategy that favors mathematical logical thinking, allowing students to be actors of their own knowledge with a high development of reasoning.
effect of the simple moving average on the movement of bank stock prices applied research in a sample of Iraqi private commercial banks
Authors: Jihad Asaad Ghani , Ismail Ahmed Muqdad
Published: July 2022

This study aims to identify one of the indicators of technical analysis, which is the simple moving average (SMA), and its impact on the movement of stock prices in private Iraqi commercial banks, by standing on the methods used in technical analysis and its various Models in general, and ways to benefit from them in determining the direction of stock prices in order to make the appropriate investment decision to buy or sell, diagnose the obstacles and difficulties that the participants face in predicting stock prices, and propose solutions and recommendations to overcome and overcome them from a scientific and practical perspective. Where the research community consisted of (25) Iraqi private commercial banks, while the research sample consisted of (5) banks with a rate of (20%) of the research community. The study used the analytical approach to the financial statements during the period between (1/2/ 2022-30/4/2022, where the financial data (banks stock prices) were calculated through the mathematical equation of the Simple Moving Average Index (SMA)) .
Smart car parking system for smart cities using IoT
Authors: Surya M. J. Aswin Jaya , Karthick P. S. Kamalesh , Raja P. Senthil
Published: July 2022

Using internet of things technology, an effective and smart solution to automate the administration of the parking system that assigns an efficient parking spot. The Internet of Things gives wireless connectivity to the system, and the user may keep track of the parking area's availability. With a growth in the number of automobiles in metropolitan centres, road congestion is a big issue. The purpose of this study is to address this issue. The user frequently wastes time and effort looking for available parking spaces in a certain parking lot. The user receives parking information through notification. As a result, the user's waiting time for a parking place is reduced.
Multifaced Hungarian Kin-State Activism in Szeklerland: Rebuilding the Last ‘Nation' Through Restorative Nostalgia and Lieux de Mémoire
Authors:   Johan Skytte Institute of Political Studies at the University of Tartu, Estonia, Chiruta Ionut
Published: July 2022

This article explores the cultural dynamics of Fidesz's kin-state policies achieved in Romania between 2015 and 2020, particularly in the enclave of Szeklerland. In recent years, Fidesz's external policies constructed a transborder “synthetic home” connected to Hungary by memory spaces. Consequently, this study investigates how the ethnocultural reproduction and redefinition of the Hungarian heritage in Romania has evolved under these influences. To understand Fidesz's ethnic parallelism, this article studies Fidesz's overseas financial assistance for Hungarian cultural heritage and the actions of long-distance Hungarian nationalists from Romania. By analysing the lieux de mémoire from Szeklerland and the activities of political agents, this paper reveals how public spaces are nationalised under a Hungarian identity. This paper also shows that the dialectic of lieux, in the case of minorities separated from their homeland, features both a restorative process and commemorative rhetoric of a positive past. Finally, this paper reveals that lieux de mémoire are instrumental when synthetically reconstructing the lost home through religious and nationalist revivals.
Epónimos y terminología moderna en la historia del hipertiroidismo
Authors: Jácome Roca Alfredo
Published: July 2022

Propósito. El objetivo de esta revisión es la de conocer en el contexto actual el uso de los numerosos epónimos del hipertiroidismo del siglo XIX, y la de describir la historia correspondiente.
Contenidos.  Usando las palabras clave en varias bases de datos, encontramos información entre 2012-2022. Posteriormente narramos la historia de hechos y personajes involucrados en las primeras observaciones sobre el bocio exoftálmico hipertiroideo.
Contribuciones. La utilización de los epónimos del hipertiroidismo se ha reducido notoriamente, y la tendencia actual es la de usar palabras descriptivas y un sistema de códigos que permite explicar más claramente la enfermedad que afecta a un paciente dado, cuando se trata de enviar una cuenta de cobro.
Hiperplasia adrenal congénita asociada a mutación no descrita en el gen CYP17A1
Authors: Builes-Montaño Carlos E. , Rueda-Galvis Myriam V. , Fragozo-Ramos María C. , Agredo-Delgado Valentina , Zea-Lopera Julián , Muñetón-Peña Carlos M.
Published: July 2022

Introducción: La deficiencia de 17?-hidroxilasa / 17,20-liasa es causada por un defecto en el gen CYP17A1 que codifica una enzima que expresa tanto actividad 17?-hidroxilasa como 17,20-liasa en las glándulas suprarrenales y las gónadas. El fenotipo de esta condición es muy característico, pero lo pueden compartir otros defectos enzimáticos. La adecuada relación genotipo-fenotipo es importante para el correcto diagnóstico, enfocar el tratamiento y la consejería a los pacientes. 
Objetivo del caso: Reportar por primera vez una variante genética potencialmente relacionada con una hiperplasia adrenal congénita  en una paciente con un fenotipo compatible con una deficiencia de 17?-hidroxilasa y la 17,20-liasa.
Presentación del caso: Se presenta el caso de una mujer que consultó por infantilismo sexual y amenorrea primaria en presencia de cariotipo 46XX. Durante su evolución cursó con hipertensión e hipokalemia que condujo a la sospecha diagnóstica de una hiperplasia adrenal congénita (HAC).  El estudio genético reveló una mutación de cambio de sentido erróneo, homocigota, en el exón 8, c.1250 T>C; p. Phe417Ser del gen de la CYP17A1.  Se ha demostrado previamente que mutaciones en esta localización suprimen las actividades 17?-hidroxilasa y la 17,20-liasa lo que explica el fenotípico clínico observado. Reportamos por primera vez en el mundo la mutación de cambio de sentido erróneo, c.1250 T>C; p. Phe417Ser, en el gen CYP17A1, relacionada con la HAC.
Conclusión: Los análisis genéticos en todos los pacientes con HAC son necesarios para definir la frecuencia de esta y otras mutaciones en la población colombiana y relacionar el fenotipo de la enfermedad con su genotipo.
Analogos de GLP1: marcando nuevas rutas en el manejo de la diabetes
Authors: Casas Figueroa Luz Angela
Published: July 2022

En los inicios del siglo XX (1902), los investigadores Bayliss y Starling describieron que las secreciones pancreáticas se producían por estímulos químicos, así como estímulos neurales, y que las secreciones que provenían del intestino contenían “algo” que se liberaba dentro de la circulación y tenía la capacidad de estimular las secreciones pancreáticas, denominándose la primera hormona como secretina. Estos hallazgos contribuyeron a comprender que existen interacciones clave entre las hormonas y el sistema nervioso, las cuales son necesarias para las funciones gastrointestinales. Pocos años después se consideró que estas hormonas contribuían a la regulación de la glucosa en los pacientes diabéticos, apoyados en los experimentos de Barre, clarificándose posteriormente con las investigaciones publicadas por Perley y Kipnis el efecto de la incretina, dada por las hormonas gastrointestinales después de la carga oral de glucosa. En 1983 se aisló del intestino un péptido similar al glucagón (GLP-1) y se descubrió que este estimulaba la secreción de insulina e inhibía la secreción de glucagón, además, se encontraron efectos inhibidores sobre la ingesta de alimentos y el vaciamiento gástrico, lo cual impulso al desarrollo de tratamientos basados en GLP-1.
A NOVEL VALIDATED BIO-ANALYTICAL METHOD DEVELOPMENT FOR AZELNIDIPINE (DIHYDROPYRIDINE) IN INDIAN HUMAN PLASMA BY LIQUID CHROMATOGRAPHY QUADRUPLE TANDEM MASS SPECTROMETRY (LC-ESI-MS/MS, API-4000) WITH AN APPLICATION TO IN VIVO PHARMACOKINETIC AND BIOEQUIVA
Authors:   Bio-Analytical Unit, TAAB Biostudy Services, 77/2/1B/1 Baderaipur Road, Jadavpur - 700 032, Kolkata, West Bengal, India, Mandal Pallab , Chakraborty Soumya , Bera Rakesh , Saha Chiranjit , Pal Tapan K. , Ghosh Balaram , Poddar Sourav
Published: July 2022

Azelnidipine is a dihydropyridine used as a calcium channel blocker. The main aim of this study was to develop a validated bio-analytical method (as per US-FDA and EMA guidelines) for in vivo pharmacokinetic and bioequivalence study of azelnidipine in human plasma by LC-MS/MS, API-4000. In this method, the drug was ionized in negative mode and gave adequate response because this drug was highly sensitive and had high electron affinity due to the presence of the electron-withdrawing the nitro group in the structure of azelnidipine. The deprotonated precursor ions [M-H]- at mz-1 581.2 and consistent fragment ion selected was mz-1 491.0. For internal standard, the deprotonated precursor ions [M-H]- at mz-1 269.0 (highest peak) was observed in Q1 MS and characteristic product ions or fragment ions found in Q3 MS were at mz-1 169.8. For plasma extraction, the liquid-liquid extraction technique was used. The calibration concentrated points of azelnidipine were 0.15 to 10.00 ng mL-1 including LLOQ 0.15 ng mL-1, LQC 0.46 ng mL-1, MQC 3.75 ng mL-1 and HQC 7.50 ng mL-1. The LOD value was 0.07 ng mL-1. The result of matrix effect of internal standard (tolbutamide) ranges between 93.51% - 98.68% and 91.94% - 95.07% for azelnidipine, recovery result after extraction of plasma of azelnidipine was 90.73% to 100.46% and for IS it was 95.95% to 98.82%. After administration of film-coated azelnidipine 8mg of test drug at 2.92±0.77h. Cmax obtained was 5.98±1.93ng mL-1 whereas for reference drug it was 6.18±1.96ng mL-1 Cmax at 3.03±0.98h. This method was validated as per regulatory guidelines and is highly selective, specific, highly sensitive and reproducible with low ionic suppression and high recovery, High throughput screening method was successfully applied to in vivo pharmacokinetic and bioequivalence study of azelnidipine.
2D QSAR STUDIES OF NOVEL TRIAZOLINONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS USING TOPOLOGICAL DESCRIPTORS
Authors:   Department of Pharmaceutical Chemistry, School of Pharmacy, Devi Ahilya University, Khandwa Road, Indore - 452 001, Madhya Pradesh, India, Sharma Mukesh C. , Kohli D. V.
Published: July 2022

Quantitative Structure Activity Relationship (QSAR) model on a series of triazolinone derivatives acting as angiotensin II receptor using partial least squares regression analysis was performed to compute the relationship with 2D structure descriptors. The computational studies were performed with trial version V-life Molecular Design Suite software. The developed models were validated using an internal predictive power and predictivity for the external test set of 0.8653, and 0.7981 were obtained. The F test value shows the overall statistical significance level. Models developed in this study have potential application in the prediction of binding affinity for the newly synthesized compounds.
FORMULATION DEVELOPMENT OF DICLOFENAC SODIUM LOTION USING MIXED SOLVENCY CONCEPT AND IN VITRO EVALUATION
Authors:   Department of Pharmacy, Shri G.S Institute of Technology & Sciences, 23, Sir M. Visvesvaraya Marg, Vallabh nagar, Indore - 452 003, Madhya Pradesh, India, Padiyar Anirudh , Maheshwari Rajesh K.
Published: July 2022

The concept of mixed solvency is an emerging field which can serve as a new method for solubility enhancement and therefore deserves urgent attention of the scientific community to assess its efficiency and applicability. Mixed solvency concept suggests that each substance present on the earth whether solid, liquid or gas has solubilizing power. An objective of the present research was to develop an aqueous based diclofenac sodium lotion and to prove solubilizing power of solid substances. The described research is one typical example where safe concentrations of solid additives have been used to prepare aqueous based topical lotion (solution) of diclofenac sodium (a sparingly water soluble drug as per IP solubility descriptive term). Conventionally, diclofenac sodium is a drug of first choice as NSAID in the treatment of osteoarthritis, due to its less dose and lesser side effects as compared to other drugs. Diclofenac or its pharmaceutically acceptable salts and other NSAIDs produce their anti-inflammatory analgesic action through inhibition of prostaglandin synthesis. In the present research, blend of caffeine and niacinamide is used as solubilizer for solubility enhancement of diclofenac sodium. Approximate solubility of diclofenac sodium in DM water at room temperature was 1.2 % w/V. An aqueous blend containing two solid additives, namely niacinamide (5 % w/V) and caffeine (5 % w/V) was observed to have approximate solubility of diclofenac sodium 10 % w/V at room temperature. Therefore, a topical lotion of diclofenac could be developed. Diclofenac sodium, vitamin B3 (niacinamide), caffein, glycerin and sodium sulfite, were used for preparing topical formulation. Selection of solubilizers was done on the basis of solubility studies in various blends of solubilizers. Aqueous diclofenac lotion was formulated and in vitro evaluation was performed.
Problem-Based Learning in Traditional Chinese Medicine
Authors: Law Siukan , Au Dawn Chingtung , Leung Albert Wingnang , Xu Chuanshan
Published: July 2022

Problem-Based Learning (PBL) is innovative teaching approved nowadays. Chinese medicine is a difficult subject to translate and explain in a foreign language, such as English. Can PBL incorporate with Chinese medicine and learn in the correct direction of Traditional Chinese Medicine (TCM)? However, there are still some considerations and investigations on the PBL for TCM.
The Impact of COVID-19 and Challenges of Online Learning: Evidence from Technologically Under-developed Country
Authors: Ghimire Subekshya , Khanal Jeevan
Published: July 2022

Objective: To determine the difficulties faced by students that are learning online in less technologically advanced nations following the COVID-19 pandemic. We intend to find out some of the difficulties that students encounter, and how students perceive themselves in this new learning environment. Methods: A total of 18 students pursuing a Master of Philosophy (M.Phil.) degree from two universities in Nepal were included in this study. Semi-structured interview questions were used to reach the findings. Results: Four themes emerged from the data collected about the challenges faced by students: (1) Monotony and difficulties adjusting to online learning. (2) Uncertainty and inability to focus. (3) A feeling of being ignored. (4) Inconsistency between the students’ preferred method of learning and the learning environment. Conclusion: The greatest challenges of online learning were linked to the learning environment, monotony and difficulties adjusting to the new mode of learning. While reviewing the literature, we did not come across any proper term that adequately describes the doubts that students have about themselves, or the sense of loss of existence felt by the students. Therefore, the phrase “Edu-Centric Inexistence” was coined to describe these emotions.
Talking Testimonio: Telling History and Memory
Authors: Perez Domino Renee , Cantú Norma E.
Published: July 2022

Distinct from personal or first-person narrative, testimonio is both an action and a form for transmitting particular kinds of experiences. Pushing the boundaries around how people think of testimonio and the various forms it can take, the authors reflect on witnessing, community, and empowerment as related to testimonio to show its ongoing utility and necessity for folklorists and literary critics. Through their contrapuntal conversation, the authors identify and engage with some of the major conversations and criticisms related to testimonio in the field of folklore and beyond.
10 Lessons in Community Love
Authors: Morales Selina , Alvarez Maribel
Published: July 2022

This conversation engages one of folklore's foundational tasks: the recording, archiving, and sharing of the diversity of experiences and points of view that shape human experience. Modeling the practice of collaboration they advocate for the folklorist/documentarian, the authors Selina Morales and Maribel Alvarez explore through conversation a pedagogy of documentation from a critical racial justice lens. Moving across a spectrum from family stories to public folklore projects and reflecting on their deep roots in community organizing, they draw attention to the dynamics of power that impact whose stories are told and which assumptions of disciplinary knowledge are applied to theorizing documentation practices.
Doing Research of/from/at Home: Fieldwork Research Ethics in Latinx Contexts
Authors: Martínez-Rivera Mintzi Auanda
Published: July 2022

This essay explores the idea, construction, and performance of campo/field. Specifically, it challenges narrow, colonial, Western, imperialistic approaches that imagined campo/field as a remote area, removed from civilization and inhabited by Indigenous others. Contrary to this, and inspired by decolonial and anti-oppressive research methodologies, this essay provides alternative conceptualizations and ways of beingdoingseeing the campo/field. In addition, it provides a brief overview of works conducted by and of Latinx communities, and how scholars have presented different ways of engaging, documenting, and imagining Latinx cultural contexts.
Contrapunteo 1: Intersectionality and Genealogies of Third World Feminist Thought
Authors: Mayer-García Eric
Published: July 2022

In this essay, I define “Latinx” as a gender-inclusive umbrella term, as a descriptor that emphasizes queer feminist critique and community-making, and as a cultural identity emerging through difference as a connective tissue and vitalizing force. I begin by unpacking some aspects of the relationship between ideological subjugation and Latinx difference as a way of establishing the importance of multiplicity and fluidity to latinidad as a decolonial project in the United States. Discussing several examples of feminist theater, I trace the connections between Latinx and the philosophy of early generations of Third World Feminist thinkers. Specifically, I explore the importance of intersectionality to the emergence and meaning of Latinx.
Rekeying Latinx Performance: Gesture, Ancestors, and Community
Authors: Otero Solimar
Published: July 2022

This keyword article is about how hemispheric, Latinx, Afro-Latinx, transnational feminist, and queer “performance” is rooted in an understanding of the importance of rematerialization as a vitalizing, regenerative force. This means that performances take on multiple forms of presence that refer to everyday acts of creative expression as resilience. Further, performance practices in these contexts are tied to ritual acts that serve to ignite moments of recognition, inspiration, and action for communities.
Pengaruh Pendekatan Contextual Teaching And Learning Terhadap Minat Belajar Peserta Didik Mata Pelajaran Matematika
Authors: Muamar Muamar Achmad Hamdani , Agustyarini Yhasinta
Published: July 2022

Jika dilihat dari data PISA tahun 2018, Indonesia berada pada posisi ke-72 dari 79 negara dalam bidang matematika. Salah satu alasannya adalah penjelasan yang abstrak dan sulit dipahami anak, sehingga sangat penting untuk diberikan pendekatan CTL atau kontekstual yang menghubungkan materi dan contoh secara langsung dengan dunia nyata di lingkungan sekitar siswa. Sehingga penjelasan materi mudah dipahami oleh siswa. Penelitian ini dilakukan untuk mengetahui pendekatan CTL terhadap minat belajar lulusan kelima MI Addiniyah Jiyu pada mata pelajaran matematika materi pengolahan data. Jenis penelitian ini menggunakan desain kontrol satu kelompok dengan sampel 18 siswa dari semua kelas V. Penelitian ini menggunakan angket dan pertanyaan dalam pengumpulan data selama penelitian. Berdasarkan hasil analisis data yang telah dilakukan peneliti dapat diketahui bahwa terdapat pengaruh pendekatan CTL terhadap minat belajar siswa kelas V MI Addiniyah jiyu pada pelajaran matematika pada materi pengolahan data. Artinya, jika uji-t sampel berpasangan kuesioner dan pertanyaan menghasilkan nilai Sig (2-tailed) 0,05, maka H0 ditolak dan Ha diterima.
Comparison Between Preoperative Inflammation Based Scores and TNM Staging in Patients with Oral Cancer
Authors: Ram Bhargav
Published: July 2022

Abstract Background: India, one of the countries with the highest incidence of oral cancer, accounting for 30% of all new oral cancer cases in the world. Therefore, strong diagnostic markers are critical for the diagnosis and survival of patients suffering from oral cancer. Based on this relationship between inflammation and cancer progression, several inflammation-based scores have been demonstrated to have diagnostic and prognostic value in many types of malignant solid tumours. Objective: To compare the correlation between systemic inflammation based prognostic scores and tumour node metastasis (TNM) stage in patients undergoing oral cancer treatment. Methods: The inflammation-based scores were calculated for 120 patients with oral squamous cell carcinoma divided into four groups based on TNM staging. Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), tumour size, nodes involved were analysed. Statistics were performed to compare the diagnostic value of the selected scores and TNM stage. Results: This current study compares 30 patients in each stage of TNM stages 1,2,3 and 4. The mean tumour size is 1.8 x 1.41, 3.23x2.28, 2.85x2.43 and 3.78x 3.06 in stage 1,2,3 and 4 respectively. The largest lymph node measurable was 1.33x1.36 in stage 3 and 1.84x 1.38 in stage 4. The number of lymph nodes involved in stage 3 are 1.1 and 2.82 in stage 4. The mean NLR in stage 1,2,3 and 4 were 2.68, 2.72, 3.17 and 3.68 respectively. The mean PLR in stage 1, 2,3 and 4 were 106.4, 117.8, 108.2 and 182.2 respectively. Conclusion: The present study indicates that elevated NLR and PLR values are associated with advanced stages of TNM staging for Oral squamous cell carcinoma.
English-Medium Instruction and Content Learning in Freshman Year: An Investigation of a Saudi University Students’ Challenges and Learning Strategies
Authors: Altheyab Nourah A. , Alalwi Fahd Sh.
Published: July 2022

The present study investigates the challenges that science freshmen perceive in English-medium instruction at Prince Sattam bin Abdelaziz University in terms of language and learning as well as the frequency of relevant learning strategies employed by students. A questionnaire was used to collect data from 376 students enrolled in the First Year Program at Prince Sattam Bin Abdelaziz University, considering their gender, scientific tracks, and previous English exposure. Results reveals that females were less comfortable communicating with professionals in their classrooms. Simultaneously, freshmen females perceive greater challenges in content comprehension, knowledge application, and learning adaptability. Therefore, they relied on learning strategies supported by L1 more frequently than males. Comparison of groups based on tracks shows that engineering students have more difficulty communicating with professionals than medical students. Furthermore, freshmen with extensive prior English exposure had fewer difficulties communicating with their peers and professionals. They perceived fewer difficulties with content comprehension, knowledge application, and learning adaptability. In contrast, freshmen with little prior exposure to English relied more on L1-related learning strategies. The findings show significant differences in perceiving EMI-related challenges and adopted learning strategies based on the relevant variables. They suggest that the shift from high school Arabic-medium education to English-medium instruction in higher education requires careful institutional and individual planning.
Docencia con perspectiva de género: un must en la sociedad actual
Authors: Borges Blázquez Raquel
Published: July 2022

Aplicar la perspectiva de género en las clases de Derecho Procesal es un must en
la sociedad actual. Para llevar a cabo este proceso de deconstrucción utilizo la
tecnología como aliada. Realizamos un Kahoot! previo a la impartición de la parte
procesal de la asignatura de Género y Violencia donde repasamos los principios
procesales básicos. Estos Kahoots! se han realizado en los Grupos de la asignatura de
Género y Violencia del Grado en Criminología (35072). El porcentaje de respuestas
correctas fue del 64% en el grupo de Valenciano y del 66,06% en el grupo de castellano.
Estas respuestas nos muestran la pervivencia de mitos erróneos en el imaginario
colectivo, inclusive en el alumnado de Derecho.
PowerPoint como herramienta gamificadora en grados científico-técnicos
Authors: Consejo Alejandra , Sevillano Pascual
Published: July 2022

El "Trivia challenge" es un recurso didáctico de implementación sencilla
en Microsoft PowerPoint con el objetivo primario de aumentar el dinamismo de las clases
magistrales de Física (asignatura obligatoria de primer curso en grados de ingeniería).
Objetivos secundarios son fomentar la cercanía del profesor al estudiantado, y favorecer
la colaboración entre alumnos. El "Trivia challenge" es un juego de preguntas
y respuestas. Puede implementarse en una sola diapositiva de PowerPoint. Implementar el
recurso en PowerPoint ofrece mucha flexibilidad al docente: se pueden añadir imágenes y
vídeos; adaptar el tiempo del cronómetro; modificar la cantidad de opciones de
respuesta, etc. Para que otros docentes puedan aplicarlo, en el presente trabajo se
describe en detalle cómo implementar dicho recurso en PowerPoint.
La farmacogenética: la llave para salir del aula
Authors: García García Cristina B. , Sangüesa Sangüesa Estela , Concha Mayayo Julia , Ribate Molina Mª Pilar
Published: July 2022

En esta experiencia se propone una actividad de gamificación educativa, como el
escape room, con el objetivo de fomentar la motivación de los alumnos del Grado en
Farmacia por el aprendizaje de la Farmacogenética, la adquisición de conocimientos sobre
esta ciencia y el desarrollo de competencias básicas para su futuro profesional. Se
trata de un juego en el que los alumnos tendrán que resolver diferentes enigmas
vinculados a la Farmacogenética que les permita salir del aula en menos de una hora. Se
plantea un escenario que simula una situación real que permita a los alumnos integrar
los conocimientos adquiridos en la asignatura, así como los de otras materias del
grado.
Recursos digitales en la enseñanza de las Clásicas: una experiencia con
Nearpod
Authors: Lesage Gárriga Luisa
Published: July 2022

El entorno educativo está experimentando cambios drásticos que tendrán una
continuidad más allá de la pandemia. Por ello, debemos reflexionar sobre la adecuación y
utilidad de herramientas y aplicaciones didácticas de cara a implementarlas con unos
objetivos claros. La enseñanza de las lenguas cultura clásicas, de corte generalmente
tradicional, no es una excepción: es necesaria una actualización metodológica que
permita sumarnos a una nueva modalidad educativa ineludible. A partir de la experiencia
con Mito en la Cultura Digital y el uso de Nearpod, se reflexiona sobre cómo la correcta
implementación de herramientas digitales en la enseñanza de las Clásicas contribuye a
asegurar la asistencia y atención del alumnado y fomentar su participación activa en un
entorno de enseñanza online-híbrida.
Tú también puedes ser un booktuber
Authors: Franco González Verónica
Published: July 2022

Se trata de una experiencia de innovación docente que desarrolla la competencia
digital y la competencia comunicativa oral en el aula de Secundaria desde la materia de
Lengua castellana y Literatura. Si bien se trabaja la competencia comunicativa de forma
constante en esta asignatura, a las destrezas orales no se les ha dedicado demasiado
tiempo, pues a veces la extensión del currículo no nos permite a los docentes tratar
cuestiones eminentemente prácticas como sería este caso. Aquí exponemos un proyecto
desarrollado a partir del fenómeno de los booktubers como una estrategia para fomentar
la lectura al tiempo que se desarrollan las habilidades comunicativas y el uso de las
TIC, con el objetivo de generar mayor motivación entre nuestros alumnos.
Un ejemplo de aplicación del pensamiento de diseño en Lengua Castellana y
Literatura
Authors: Ramírez Quesada Estrella
Published: July 2022

Este capítulo muestra una aplicación del pensamiento de diseño, técnica originada
en el ámbito empresarial, en el aula de Lengua Castellana y Literatura. Así pues, se
presenta el contexto y el marco teórico de la actividad, además de su desarrollo,
atendiendo a la temporalización (una semana en la que los estudiantes tuvieron que
diseñar objetos para distintos personajes literarios) y a la situación de pandemia de
covid-19, lo que muestra la adaptabilidad del enfoque. Finalmente, se constata que los
resultados de la experiencia de innovación fueron satisfactorios en cuanto a la
participación y recepción por parte del alumnado y se ofrecen indicaciones para futuras
actuaciones.
Enseñanza de elementos tridimensionales mediante diseño 3D
Authors: Vergara Rodríguez Diego , Martín Herráez Fernando , Fernández Arias Pablo , García Ajates Javier , Gómez Vallecillo Ana Isabel , Ordóñez Olmedo Eva
Published: July 2022

La falta de habilidades espaciales del alumnado es uno de los aspectos que más
dificultades presenta al profesorado cuando se deben explicar conceptos 3D. En este
sentido, el uso de las TIC puede ayudar al docente en su labor diaria y, por ello, cada
día existen más experiencias educativas con diferentes recursos digitales para explicar
este tipo de contenidos. En este artículo se presenta una experiencia educativa en 2º
curso de Bachillerato usando las TIC para reforzar la comprensión espacial de las redes
cristalográficas, en la asignatura Tecnología.
Determinants of Rural Youth Participation in Livestock Farming Activities in Andhra Pradesh
Authors:   Department of Veterinary and A.H. Extension Education, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati, Andhra Pradesh, Anusha Donapati
Published: July 2022

The study was undertaken to fi nd out the determinants of rural youth participation in various livestock farming activities in Kadapa, Nellore and Srikakulam districts of Andhra Pradesh. The fi ndings of the study revealed that the variables namely age, land holding, education levels, training received, annual income, employment generation, herd size, mass media exposure, extension contact, market orientation, risk orientation, economic orientation, decision making behavior, knowledge, perception and livelihood security through dairy farming had positive and signifi cant relationship with the participation of rural youth in dairy farming. The variables gender, education, family background, training received, knowledge, perception, mass media exposure, extension contact, economic orientation, decision making behavior, annual income, market orientation, employment generation had infl uence over the participation of rural youth in sheep/goat farming activities. Gender, education, perception, employment generation, income generation, mass media exposure, extension contact, market orientation, decision making behavior infl uenced the participation in backyard poultry farming and the variables gender, economic orientation, herd size, livelihood security had infl uence over the participation in pig farming