bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic Introgression and Morphological Variation in Naked-Back Bats (Chiroptera: Mormoopidae: Pteronotus Species) along Their Contact Zone in Central America
Authors: Méndez-Rodríguez Aline , Juste Javier , Centeno-Cuadros Alejandro , Rodríguez-Gómez Flor , Serrato-Díaz Alejandra , García-Mudarra Juan Luis , Guevara-Chumacero Luis Manuel , López-Wilchis Ricardo
Published: April 2021

Two sibling bare-backed bat species (Pteronotus fulvus and P. gymnonotus) have been traditionally differentiated by their size. However, intermediate specimens between the two species have been found in sympatric populations along southern Mexico and it has been suggested that they may be the outcome of a hybridization process between the two species. We used one mitochondrial (COI), three nuclear markers (PRKCL, STAT5A and RAG2) and 13 microsatellites to explore the evolutionary relationships between these two species and elucidate whether the intermediate morphotypes correspond to hybrid individuals. These markers have been analyzed in sympatric and allopatric populations of the two species plus the closely related species Pteronotus davyi. We confirmed the species-level differentiation of the three lineages (P. fulvus, P. davyi and P. gymnonotus), but the phylogenetic hypotheses suggested by the nuclear and mitochondrial markers were discordant. We confirm that the discordance between markers is due to genetic introgression through the mitochondrial capture of P. fulvus in P. gymnonotus populations. Such introgression was found in all P. gymnonotus specimens across its sympatric distribution range (Mexico to Costa Rica) and is related to expansion/retraction species distribution pulses associated with changes in forest distribution during the Quaternary climate cycles. Microsatellite analyses showed contemporary genetic contact between the two sympatric species and 3.0% of the samples studied were identified as hybrids. In conclusion, we found a historical and asymmetric genetic introgression (through mitochondrial capture) of P. fulvus into P. gymnonotus in Mexico and Central America and a limited contemporary gene exchange between the two species. However, no relationship was found between hybridization and the intermediate-sized specimens from southern Mexico, which might likely result from a clinal variation with latitude. These results confirm the need for caution when using forearm size to identify these species in the field and when differentiating them in the laboratory based on mitochondrial DNA alone.
Tomato Landraces Are Competitive with Commercial Varieties in Terms of Tolerance to Plant Pathogens—A Case Study of Hungarian Gene Bank Accessions on Organic Farms
Authors: Boziné-Pullai Krisztina , Csambalik László , Drexler Dóra , Reiter Dániel , Tóth Ferenc , Tóthné Bogdányi Franciska , Ladányi Márta
Published: April 2021

Landraces are generally neglected by industrialized agriculture, regardless of their potential to provide valuable genetic material for breeding and to diversifying the available assortment for producers and markets. They may also excel in certain plant protection issues with possible resistance or tolerance to plant pathogens. This is the first report on the disease susceptibility traits of Hungarian on certain indeterminate and determinate tomato gene bank accessions under on-farm organic conditions. For this, a three-year on-farm experiment was conducted in two management systems, open-field and protected. Yield and disease symptoms data obtained from ten tomato landraces were compared to commercial varieties. The incidence and severity of three important diseases (caused by late blight ‘Phytophthora infestans’, early blight ‘Alternaria solani’ and Septoria leafspot ‘Septoria lycopersici’), as well as yield, were recorded and assessed. According to these results, there were no significant difference between landraces and control varieties (San Marzano, Kecskeméti 549) regarding the studied parameters, and year was a determinant factor in the occurrence and severity of the infection of the studied diseases. In 2016, rainy, humid weather induced a severe late blight infection, causing serious damage to the open field, while the weather in 2015 and 2017 was favorable for tomato production and our measurements. There were some differences within and between landraces in terms of susceptibility. The investigation revealed that certain accessions can be highly recommended, e.g., the indeterminate ‘Fadd’ (RCAT030275) and ‘Mátrafüred’ (RCAT057656) had suitably high yields with significantly lower susceptibility to late blight, and the determinate ‘Szentlőrinckáta’ (RCAT078726) with high yield as well as tolerance to early blight is also recommendable, but it is sensitive to late blight under an adverse environment. This study suggests that landraces are competitive with the studied commercial varieties under organic production systems. Considering yield and the prevention of the major diseases of tomato, the studied tomato gene bank accessions are recommended for organic field and protected management systems.
Radiomics and Artificial Intelligence Analysis with Textural Metrics Extracted by Contrast-Enhanced Mammography in the Breast Lesions Classification
Authors: Fusco Roberta , Piccirillo Adele , Sansone Mario , Granata Vincenza , Rubulotta Maria Rosaria , Petrosino Teresa , Barretta Maria Luisa , Vallone Paolo , Di Giacomo Raimondo , Esposito Emanuela , Di Bonito Maurizio , Petrillo Antonella
Published: April 2021

The aim of the study was to estimate the diagnostic accuracy of textural features extracted by dual-energy contrast-enhanced mammography (CEM) images, by carrying out univariate and multivariate statistical analyses including artificial intelligence approaches. In total, 80 patients with known breast lesion were enrolled in this prospective study according to regulations issued by the local Institutional Review Board. All patients underwent dual-energy CEM examination in both craniocaudally (CC) and double acquisition of mediolateral oblique (MLO) projections (early and late). The reference standard was pathology from a surgical specimen for malignant lesions and pathology from a surgical specimen or fine needle aspiration cytology, core or Tru-Cut needle biopsy, and vacuum assisted breast biopsy for benign lesions. In total, 104 samples of 80 patients were analyzed. Furthermore, 48 textural parameters were extracted by manually segmenting regions of interest. Univariate and multivariate approaches were performed: non-parametric Wilcoxon–Mann–Whitney test; receiver operating characteristic (ROC), linear classifier (LDA), decision tree (DT), k-nearest neighbors (KNN), artificial neural network (NNET), and support vector machine (SVM) were utilized. A balancing approach and feature selection methods were used. The univariate analysis showed low accuracy and area under the curve (AUC) for all considered features. Instead, in the multivariate textural analysis, the best performance considering the CC view (accuracy (ACC) = 0.75; AUC = 0.82) was reached with a DT trained with leave-one-out cross-variation (LOOCV) and balanced data (with adaptive synthetic (ADASYN) function) and a subset of three robust textural features (MAD, VARIANCE, and LRLGE). The best performance (ACC = 0.77; AUC = 0.83) considering the early-MLO view was reached with a NNET trained with LOOCV and balanced data (with ADASYN function) and a subset of ten robust features (MEAN, MAD, RANGE, IQR, VARIANCE, CORRELATION, RLV, COARSNESS, BUSYNESS, and STRENGTH). The best performance (ACC = 0.73; AUC = 0.82) considering the late-MLO view was reached with a NNET trained with LOOCV and balanced data (with ADASYN function) and a subset of eleven robust features (MODE, MEDIAN, RANGE, RLN, LRLGE, RLV, LZLGE, GLV_GLSZM, ZSV, COARSNESS, and BUSYNESS). Multivariate analyses using pattern recognition approaches, considering 144 textural features extracted from all three mammographic projections (CC, early MLO, and late MLO), optimized by adaptive synthetic sampling and feature selection operations obtained the best results (ACC = 0.87; AUC = 0.90) and showed the best performance in the discrimination of benign and malignant lesions.
Partial Discharge Analysis and Simulation Using the Consecutive Pulses Correlation Method
Authors: Kozák Ondřej , Pihera Josef
Published: April 2021

The behaviour of partial discharge as consequences of an alternating current (AC) is already well defined. AC partial discharges have completely different behaviour, background physics and parameters than partial discharges (PD) under direct current (DC) stress. This paper focuses on the most used and promising evaluation method of the PD DC stress—pulse sequence analysis (PSA). The first step is understanding and verifying the mechanisms and principles of this method. It is provided by well-known fundamentals of AC PD and by comparison with the other diagnostic and fault-locating methods such as phase-resolved partial discharge (PRPD) and pulse diagrams. The paper shows the PSA simulations and PD analyses performed at AC and partly at DC test conditions on typical PD test arrangements such as corona, surface and internal discharges. It is shown that the simulations performed, compared and validated with data obtained from measurements on different PD arrangements are a good match. This fact opens the way for the PD source recognition in DC, especially the time-resolved pulse sequence analysis described in detail in the paper.
Local Communities’ Energy Literacy as a Way to Rural Resilience—An Insight from Inner Peripheries
Authors: Chodkowska-Miszczuk Justyna , Kola-Bezka Maria , Lewandowska Agata , Martinát Stanislav
Published: April 2021

Energy transition is surely not only about the technological change, but it also has to necessarily reflect socio-cultural and environmental transformations on the local level. Hence, local communities’ energy literacy belongs to the crucial elements in designing successful energy transition and strengthening rural resilience. Energy literacy is a concept widely related to the multifaceted phenomenon of energy consumption, both in its individual and collective dimensions. Therefore, the aim of the present study is to analyse the level of energy literacy in rural conditions, considering its three key dimensions (awareness, attitude, and behaviour). Our reflective considerations about energy literacy build on the current knowledge that stress its importance for the reinforcement of rural resilience. The case study, Zławieś Wielka, in the north-central Poland, was selected where a social survey (N = 300) on the relation between energy literacy and rural resilience was conducted. By means of employing the cross-tabulations method for data analyses, our results signal that certain indications of the ecological awareness among the rural residents are being formed. Our findings clearly suggest that, on the one hand, the needs for more environmentally reasonable management with energy, including electricity and heat, come to the fore. On the other hand, various types of investments in improving the energy efficiency of residential buildings and utilising energy generation from renewable energy sources are observed. It seems that the surveyed community has a clear potential to become the vector for sustainable and just energy transition of the countryside. The essential conditions that urgently need to be implemented to ensure the viability of rural energy transition are the educational reinforcement within the community and more generous long-term institutional support from the central government, targeted on endogenous development and enhancing the local social capital.
Current Status of Energy Production from Solid Biomass in Southern Italy
Authors: Moliner Cristina , Arato Elisabetta , Marchelli Filippo
Published: April 2021

This work analyses and discusses data on thermochemical plants in Southern Italy that are fed with solid biomass. The analysis takes into account the biomass availability and potential together with the cost-benefit analysis using technology development and economic indicators (LCOE). A total of 63,762 units have been categorised according to the employed technology and produced energy: power plants for electricity production or cogeneration plants for combined heat and electricity production (53 plants) and thermal units for heat production (63,709 units). The eight regions of the area have noteworthy differences. In terms of electricity generated from solid biomass Calabria is by far the largest producer, followed by Apulia. Sicily, Sardinia and Molise provide lower amounts while Abruzzo, Basilicata and Campania generate almost negligible amounts. Regarding thermal production, Campania and Calabria are the largest producers, but Basilicata, Molise and Abruzzo generate the highest amount per capita. The area is far from fully exploiting its biomass potential, and there are also no district heating grids. Bioenergy can be remarkably competitive, provided that capital costs are relatively low and low-cost biomass is available, as it is the case of Italy. New applications and markets for sub-products (i.e., char, ash) would help in lowering the still not competitive economic indicators (LCOE).
The Interdependencies between Economic Growth, Energy Consumption and Pollution in Europe
Authors: Androniceanu Ane-Mari , Căplescu Raluca Dana , Tvaronavičienė Manuela , Dobrin Cosmin
Published: April 2021

The strong interdependency between economic growth and conventional energy consumption have led to significant environmental impact, especially with respect to greenhouse gas emissions. Conventional energy-intensive industries release increasing quantities every year, which has prompted global leaders to consider new approaches based on sustainable consumption. The main purpose of this research is to propose a new energy index that accounts for the complexity and interdependences between the research variables. The methodology is based on Principal Component Analysis (PCA) and combines the key components determined into a score that allows for both temporal and cross-country comparisons. All data analyses were performed using IBM SPSS Statistics 25™. The main findings show that most countries improved their economic performance since 2014, but the speed of the improvement varies a lot from one country to another. The final score determined reflects the complex changes taking place in each country and the efficiency of the governmental measures for sustainable economic growth based on low energy consumption and low environmental pollution.
Design of a 1 MWth Pilot Plant for Chemical Looping Gasification of Biogenic Residues
Authors: Marx Falko , Dieringer Paul , Ströhle Jochen , Epple Bernd
Published: April 2021

Chemical looping gasification (CLG) is a promising process for the thermochemical solid to liquid conversion route using lattice oxygen, provided by a solid oxygen carrier material, to produce a nitrogen free synthesis gas. Recent advances in lab-scale experiments show that CLG with biomass has the possibility to produce a carbon neutral synthesis gas. However, all experiments have been conducted in externally heated units, not enabling autothermal operation. In this study, the modification of an existing pilot plant for demonstrating autothermal operation of CLG is described. Energy and mass balances are calculated using a validated chemical looping combustion process model extended for biomass gasification. Based on six operational cases, adaptations of the pilot plant are designed and changes discussed. A reactor configuration using two circulating fluidized bed reactors with internal solid circulation in the air reactor is proposed and a suitable operating strategy devised. The resulting experimental unit enables a reasonable range of operational parameters within restrictions imposed from autothermal operation.
Identification of Internal Defects in Potato Using Spectroscopy and Computational Intelligence Based on Majority Voting Techniques
Authors: Imanian Kamal , Pourdarbani Razieh , Sabzi Sajad , García-Mateos Ginés , Arribas Juan Ignacio , Molina-Martínez José Miguel
Published: April 2021

Potatoes are one of the most demanded products due to their richness in nutrients. However, the lack of attention to external and, especially, internal defects greatly reduces its marketability and makes it prone to a variety of diseases. The present study aims to identify healthy-looking potatoes but with internal defects. A visible (Vis), near-infrared (NIR), and short-wavelength infrared (SWIR) spectrometer was used to capture spectral data from the samples. Using a hybrid of artificial neural networks (ANN) and the cultural algorithm (CA), the wavelengths of 861, 883, and 998 nm in Vis/NIR region, and 1539, 1858, and 1896 nm in the SWIR region were selected as optimal. Then, the samples were classified into either healthy or defective class using an ensemble method consisting of four classifiers, namely hybrid ANN and imperialist competitive algorithm (ANN-ICA), hybrid ANN and harmony search algorithm (ANN-HS), linear discriminant analysis (LDA), and k-nearest neighbors (KNN), combined with the majority voting (MV) rule. The performance of the classifier was assessed using only the selected wavelengths and using all the spectral data. The total correct classification rates using all the spectral data were 96.3% and 86.1% in SWIR and Vis/NIR ranges, respectively, and using the optimal wavelengths 94.1% and 83.4% in SWIR and Vis/NIR, respectively. The statistical tests revealed that there are no significant differences between these datasets. Interestingly, the best results were obtained using only LDA, achieving 97.7% accuracy for the selected wavelengths in the SWIR spectral range.
Price Fairness of Processed Tomato Agro-Food Chain: The Italian Consumers’ Perception Perspective
Authors: Samoggia Antonella , Grillini Giulia , Del Prete Margherita
Published: April 2021

Food consumers are increasingly searching for emotions and values when purchasing and consuming food. They search for products that ensure social and environmental sustainability, in addition to more common extrinsic product attributes, such as price, packaging, origin, and brand. In particular, there is increasing interest towards product price fairness. The current study aims at exploring consumers’ perception and understanding of price fairness, focusing on the processed tomato products agro-food chain. The study interviewed 832 people. Data were collected through an online questionnaire with the support of Qualtrics software, and data elaboration was carried out with Statistical Package for Social Science (SPSS). The elaboration includes an Exploratory Factor Analysis (EFA) to identify existing latent factors in the consumers’ perception of enabling agro-food system elements influencing farmers’ reception of fair prices. Then, factor mean values were cross-analysed with socio-economic characteristics and processed tomato consumption habits with Analysis of Variance (ANOVA). Results support the idea that consumers are limitedly aware of the processed tomato agro-food chain dynamics and consider farmers as the most unfairly remunerated partner. Women and frequently purchasing consumers of processed tomato products believe farmers should be treated more fairly. There is a difference between what consumers perceive as fair price distribution and actual price distribution among processed tomato chain actors. Further studies may focus on how fairness attribute impacts on consumer purchasing behaviour.
Bolaamphiphilic Bis-Dehydropeptide Hydrogels as Potential Drug Release Systems
Authors: Amorim Carolina , Veloso Sérgio R. S. , Castanheira Elisabete M. S. , Hilliou Loic , Pereira Renato B. , Pereira David M. , Martins José A. , Jervis Peter J. , Ferreira Paula M. T.
Published: April 2021

The self-assembly of nanometric structures from molecular building blocks is an effective way to make new functional materials for biological and technological applications. In this work, four symmetrical bolaamphiphiles based on dehydrodipeptides (phenylalanyldehydrophenylalanine and tyrosyldehydrophenylalanine) linked through phenyl or naphthyl linkers (terephthalic acid and 2,6-naphthalenedicarboxylic acid) were prepared, and their self-assembly properties were studied. The results showed that all compounds, with the exception of the bolaamphiphile of tyrosyldehydrophenylalanine and 2,6-naphthalene dicarboxylic acid, gave self-standing hydrogels with critical gelation concentrations of 0.3 wt % and 0.4 wt %, using a pH trigger. The self-assembly of these hydrogelators was investigated using STEM microscopy, which revealed a network of entangled fibers. According to rheology, the dehydrodipeptide bolaamphiphilic hydrogelators are viscoelastic materials with an elastic modulus G′ that falls in the range of native tissue (0.37 kPa brain–4.5 kPa cartilage). In viability and proliferation studies, it was found that these compounds were non-toxic toward the human keratinocyte cell line, HaCaT. In sustained release assays, we studied the effects of the charge present on model drug compounds on the rate of cargo release from the hydrogel networks. Methylene blue (MB), methyl orange (MO), and ciprofloxacin were chosen as cationic, anionic, and overall neutral cargo, respectively. These studies have shown that the hydrogels provide a sustained release of methyl orange and ciprofloxacin, while methylene blue is retained by the hydrogel network.
E hoki mai nei ki te ūkaipō—Return to Your Place of Spiritual and Physical Nourishment
Authors: Boulton Amohia , Allport Tanya , Kaiwai Hector , Potaka Osborne Gill , Harker Rewa
Published: April 2021

This paper presents the findings of the Perceptions of Papakāinga project, which explores the connection between place, genealogy, and identity for two Māori (New Zealand’s Indigenous people) communities: one living within an iwi (tribal) context, and one living within an urban context. The research explores how Māori-specific concepts which define home and identity are perceived and enacted across all participants, and how participants define ‘home’ in relation to fluid understandings of genealogy, community, and identity. Across the diverse experiences of participants, the concept of ‘whakapapa’ (genealogy), can be seen to act as a way to understand the connections between identity, people and place.
Non-Penetrance for Ocular Phenotype in Two Individuals Carrying Heterozygous Loss-of-Function ZEB1 Alleles
Authors: Dudakova Lubica , Stranecky Viktor , Piherova Lenka , Palecek Tomas , Pontikos Nikolas , Kmoch Stanislav , Skalicka Pavlina , Vaneckova Manuela , Davidson Alice E. , Liskova Petra
Published: April 2021

ZEB1 loss-of-function (LoF) alleles are known to cause a rare autosomal dominant disorder—posterior polymorphous corneal dystrophy type 3 (PPCD3). To date, 50 pathogenic LoF variants have been identified as disease-causing and familial studies have indicated that the PPCD3 phenotype is penetrant in approximately 95% of carriers. In this study, we interrogated in-house exomes (n = 3616) and genomes (n = 88) for the presence of putative heterozygous LoF variants in ZEB1. Next, we performed detailed phenotyping in a father and his son who carried a novel LoF c.1279C>T; p.(Glu427*) variant in ZEB1 (NM_030751.6) absent from the gnomAD v.2.1.1 dataset. Ocular examination of the two subjects did not show any abnormalities characteristic of PPCD3. GnomAD (n = 141,456 subjects) was also interrogated for LoF ZEB1 variants, notably 8 distinct heterozygous changes presumed to lead to ZEB1 haploinsufficiency, not reported to be associated with PPCD3, have been identified. The NM_030751.6 transcript has a pLI score ≥ 0.99, indicating extreme intolerance to haploinsufficiency. In conclusion, ZEB1 LoF variants are present in a general population at an extremely low frequency. As PPCD3 can be asymptomatic, the true penetrance of ZEB1 LoF variants remains currently unknown but is likely to be lower than estimated by the familial led approaches adopted to date.
Experimental and Numerical Investigations of a River Embankment Model under Transient Seepage Conditions
Authors: Ventini Roberta , Dodaro Elena , Gragnano Carmine Gerardo , Giretti Daniela , Pirone Marianna
Published: April 2021

The evaluation of riverbank stability often represents an underrated problem in engineering practice, but is also a topical geotechnical research issue. In fact, it is certainly true that soil water content and pore water pressure distributions in the riverbank materials vary with time, due to the changeable effects of hydrometric and climatic boundary conditions, strongly influencing the bank stability conditions. Nonetheless, the assessment of hydraulic and mechanical behavior of embankments are currently performed under the simplified hypothesis of steady-state seepage, generally neglecting the unsaturated soil related issues. In this paper, a comprehensive procedure for properly defining the key aspects of the problem is presented and, in particular, the soil characterization in partially saturated conditions of a suitably compacted mixture of sand and finer material, typical of flood embankments of the main river Po tributaries (Italy), is reported. The laboratory results have then been considered for modelling the embankment performance under transient seepage and following a set of possible hydrometric peaks. The outcome of the present contribution may provide meaningful geotechnical insights, for practitioners and researchers, in the flood risk assessment of river embankments.
The Effect of College Students’ Physical Activity Level on Depression and Personal Relationships
Authors: Kim Chang-Hwan , Song Young-Eun , Jeon Yoo-Jeong
Published: April 2021

Background: Physical activity greatly affects human physical and mental health. This study investigated the effect of college students’ physical activity levels on depression and personal relationships. Methods: Participants were 525 college students from five Korean cities. The International Physical Activity Questionnaire, Beck’s Depression Inventory, and Leary’s interpersonal orientation paper test measured physical activity volume, depression, and interpersonal relationships, respectively. Data were analyzed using descriptive statistics, reliability analysis, one-way analysis of variance (ANOVA), and Pearson’s correlation analysis. Results: The results revealed significant differences among emotional, cognitive, and synchronous symptoms of depression across activity level groups. Regarding interpersonal relationships according to physical activity, for the sociometric disposition, there were differences between groups in the sympathetic-acceptable and sociable-friendliness factors and, for the expressive disposition, in the competitive-aggressive and rebellious-distrustful factors. Conclusions: There were statistical correlations between the physical activity volume and depression and the physical activity and interpersonal relationships. Subsequent research should examine college students’ physical activities and causal relationships among various psychological variables.
Impact of COVID-19 on Swimming Training: Practical Recommendations during Home Confinement/Isolation
Authors: Haddad Monoem , Abbes Zied , Mujika Iñigo , Chamari Karim
Published: April 2021

The COVID-19 pandemic has had severe effects on communities globally, leading to significant restrictions on all aspects of society, including in sports. Several significant decisions were made to postpone or cancel major swimming events by FINA (Fédération Internationale de Natation). Swimmers were no longer allowed to continue their usual training in swimming pools and were confined to their homes. These unusual circumstances may represent a good opportunity to strengthen different areas of swimmer preparation and potentially enhance performance when resuming regular aquatic training. We searched major databases for relevant information, and the present article provides practical information on home-based training for swimmers of all ages. The COVID-19 crisis and its consequences on the swimming community have created a myriad of challenges for swimmers around the world, including maintaining their fitness level and preparing to return optimally and safely to pool training and competitions. Unfortunately, the mental consequences that might arise after the pandemic may also have an impact. We strongly recommend encouraging the swimmers to consider quarantine as an opportunity for development in specific areas of preparation and learn how to best cope with this special situation of self-isolation and/or “physical distancing” for their mental health and in case a similar situation is faced again in the future.
Testing ActiveYou II: Applying Cognitive Interviews in Improving Item Quality and Applicability of a Web-Based, Self-Report Instrument on Participation in Children with Disabilities
Authors: Steinhardt Friedolin , Jahnsen Reidun , Dolva Anne-Stine , Ullenhag Anna
Published: April 2021

Background: Children and youth with disabilities participate less in leisure activities than their nondisabled peers. Increasing participation is a primary goal of rehabilitation interventions. However, valid measures that include the individual’s perspectives and facilitating and hindering factors for participation are lacking in the Norwegian setting. In this study, ActiveYou II, a self-report, web-based instrument under development, was tested to obtain item quality and applicability. Methods: Nine children with disabilities participated in cognitive interviews, testing a first set of ActiveYou II items. The verbal probe method for cognitive interviews was applied. Results: The children’s comprehension and responses through cognitive interviews improved the applicability and item quality of ActiveYou II. Item adjustments were made to the wording of the questions and response alternatives, and the number of response alternatives were decreased where appropriate. Conclusions: The use of cognitive interviews with children before performing further psychometric testing has been very useful in the development process of ActiveYou II. Adjustments of the questions and response alternatives were made accordingly.
Knowledge, Attitudes and Practices Regarding Pre-Exposure Prophylaxis (PrEP) in a Sample of Italian Men Who Have SEX with MEN (MSM)
Authors: Voglino Gianluca , Gualano Maria Rosaria , Rousset Stefano , Forghieri Pietro , Fraire Isabella , Bert Fabrizio , Siliquini Roberta
Published: April 2021

Background: Pre-exposure prophylaxis (PrEP) is suitable for high human immunodeficiency virus (HIV)-infection risk people, foremost among whom are males who have sex with other males (MSM). This study evaluated knowledge, attitudes and practices regarding PrEP in a sample of Italian MSM, in order to hypothesize strategies to implement PrEP awareness and use. No previous study has assessed this issue; Methods: An online survey was given to an opportunistic sample of Italian MSM. The questionnaire investigated sexual behaviour and habits, HIV/acquired immune deficiency syndrome (AIDS) knowledge and PrEP awareness, attitudes and practices. Univariable and multivariable logistic regressions were conducted to identify factors associated with PrEP knowledge; Results: A total of 196 MSM participated in this survey. Overall data showed that 87.2% of participants knew what PrEP is, but only 7.5% have ever used it. The main reason for not using PrEP was the cost of the therapy (26.9%). The principal source of PrEP information was the Internet (68.4%). Being regularly tested for HIV was significantly associated with PrEP knowledge (adjusted odds ratio (AdjOR) = 3.16; confidence interval (CI) = 1.06–9.29); Conclusions: Knowledge regarding PrEP was well established, but PrEP use was not equally widespread. It is necessary to improve research on PrEP usage in order to PrEP access to be granted.
Human Adenovirus Molecular Characterization in Various Water Environments and Seasonal Impacts in Riyadh, Saudi Arabia
Authors: Nour Islam , Hanif Atif , Zakri Adel M. , Al-Ashkar Ibrahim , Alhetheel Abdulkarim , Eifan Saleh
Published: April 2021

The regular monitoring of water environments is essential for preventing waterborne virus-mediated contamination and mitigating health concerns. We aimed to detect human adenovirus (HAdV) in the Wadi Hanifah (WH) and Wadi Namar (WN) lakes, King Saud University wastewater treatment plant (KSU-WWTP), Manfouha-WWTP, irrigation water (IW), and AnNazim landfill (ANLF) in Riyadh, Saudi Arabia. HAdV hexon sequences were analyzed against 71 HAdV prototypes and investigated for seasonal influence. ANLF had the highest HAdV prevalence (83.3%). Remarkably, the F species of HAdV, especially serotype 41, predominated. Daily temperature ranges (22–45 °C and 10–33 °C) influenced the significance of the differences between the locations. The most significant relationship of ANLF and IW to WH and KSU-WWTP was found at the high-temperature range (p = 0.001). Meanwhile, WN was most correlated to ANLF at the low-temperature range (p < 0.0001). Seasonal influences on HAdV prevalence were insignificant despite HAdV’s high prevalence in autumn and winter months, favoring low temperatures (high: 22–25 °C, low: 14–17 °C) at five out of six locations. Our study provides insightful information on HAdV prevalence and the circulating strains that can address the knowledge gap in the environmental impacts of viruses and help control viral diseases in public health management.
The Impact of COVID-19 Restrictions on Mental Well-Being and Working Life among Faroese Employees
Authors: Davidsen Annika H. , Petersen Maria S.
Published: April 2021

The societal changes caused by COVID-19 have been far-reaching, causing challenges for employees around the world. The aim of this study was to assess the effect of the COVID-19 restrictions on mental well-being, working life, family life and social life among Faroese employees within a broad range of professions. A total of 1328 Faroese employees answered an anonymous self-report survey from 13 April to 4 May 2020. Employee mental well-being was only modestly affected by the restrictions and the respondents had a mean score of 50.7 on the Warwick–Edinburgh Mental Wellbeing Scale where a score between 41–44 is found to correspond with possible depression. Work commitment, work and family life, work satisfaction and work ability were all rated significantly worse after the COVID-19 outbreak than before (all p values < 0.005). Contrary to previous research, employees in health services assessed their work ability significantly higher than employees in teaching, and child and youth care (p < 0.05). Working parents had higher levels of stress and assessed their work ability significantly lower than employees without children (p < 0.05), and women tended to be more worried than men because of the pandemic. In conclusion, the overall mental well-being of Faroese employees was on an average level during lock-down in April and May 2020. Their working life seemed, however, to be worse than usual.
Mediating and Moderating Effects of Family Cohesion between Positive Psychological Capital and Health Behavior among Early Childhood Parents in Dual Working Families: A Focus on the COVID-19 Pandemic
Authors: Cho In Young , Moon Sun-Hee , Yun Ji Yeong
Published: April 2021

This study examined the mediating and moderating effects of family cohesion on the relationship between positive psychological capital and health promotion behaviors among dual working parents of young children during the COVID-19 pandemic. We collected data from 214 dual working parents and analyzed the results using the IMB SPSS version 26.0 software. We found that positive psychological capital had significant effects on both family cohesion (β = 0.19, p < 0.001) and health promotion behaviors (β = 0.26, p < 0.001), while family cohesion showed a significant mediating effect on health promotion behaviors (β = 0.34, p = 0.002). Positive psychological capital (independent variable) also had significant effects on health promotion behaviors (β = 0.19, p < 0.001). Finally, a Sobel test showed that family cohesion had a significant partial mediating effect on the relationship between positive psychological capital and health promotion behaviors (Z = 2.70, p = 0.005) but no moderating effect. Thus, it is necessary to enhance health promotion behaviors through programs focused on both family cohesion and positive psychological capital. However, the fact that participants in this study were only from South Korea highlights the requirement for future research that includes participants from different cultural contexts and social systems.
Efficacy and Pharmacological Appropriateness of Cinnarizine and Dimenhydrinate in the Treatment of Vertigo and Related Symptoms
Authors: Plescia Fulvio , Salvago Pietro , Dispenza Francesco , Messina Giuseppe , Cannizzaro Emanuele , Martines Francesco
Published: April 2021

Vertigo is not itself a disease, but rather a symptom of various syndromes and disorders that jeopardize balance function, which is essential for daily activities. It is an abnormal sensation of motion that usually occurs in the absence of motion, or when a motion is sensed inaccurately. Due to the complexity of the etiopathogenesis of vertigo, many pharmacological treatments have been tested for efficacy on vertigo. Among these drugs, cinnarizine, usually given together with dimenhydrinate, appears to be the first-line pharmacotherapy for the management of vertigo and inner ear disorders. Based on these considerations, the present non-interventional study aimed to investigate the clinical efficacy and tolerability of a fixed combination of cinnarizine (20 mg) and dimenhydrinate (40 mg) in patients suffering from vertigo-related symptoms. To this end, we enrolled 120 adults—70 males, and 50 females—with an average age of 64 years. Before beginning pharmacological treatment, all patients were screened for the intensity of vertigo, dizziness, and concomitant symptoms through the Visual Scale of Dizziness Disorders and Dizziness Handicap Inventory scales. At the end of the anamnestic evaluation, patients received the fixed-dose combination of cinnarizine (20 mg) plus dimenhydrinate (40 mg) 3 times daily, for 60 days. The results of this study provide further insight regarding the efficacy of the fixed combination when used to reduce symptoms of vestibular vertigo of central and/or peripheral origin, after both the 15- and 60-day therapies. Independent of the type of vertigo, the fixed combination was able to reduce dizziness- and vertigo-associated symptoms in more than 75% of all patients treated, starting from 15 days of therapy, and improving 60 days after starting the therapy. Interestingly, we also found differences between male and female patients in the framework of the pharmacological effects of therapy. This study provides further details concerning the therapeutic efficacy of the fixed combination of cinnarizine and dimenhydrinate, and also focuses attention on the possibility that these drugs could act in a gender-specific manner, paving the way for further research.
Illicit Drug Use and Associated Problems in the Nightlife Scene: A Potential Setting for Prevention
Authors: Feltmann Kristin , Elgán Tobias H. , Strandberg Anna K. , Kvillemo Pia , Jayaram-Lindström Nitya , Grabski Meryem , Waldron Jon , Freeman Tom , Curran Helen Valerie , Gripenberg Johanna
Published: April 2021

Illicit drug use is prevalent in the nightlife scene, especially at electronic dance music (EDM) events. The aim of the present study was to investigate illicit drug use patterns and consequences of drug use among frequent visitors of EDM events. Young adults (18–34 years old) who had visited at least six EDM events in Sweden during the past year participated in a web-based survey on drug use patterns and its consequences. Fifty-nine percent of participants had used illicit drugs during the past year, most often cannabis followed by ecstasy, cocaine, and amphetamine. Nightlife venues were identified as the main setting for the use of central stimulants, while cannabis was mostly used at home. Frequent alcohol and tobacco use was associated with illicit drug use. The most prevalent negative consequences of drug use were related to mental health, such as impairments in mood, sleep, and memory problems, but physical manifestations were also reported, such as palpitations and collapsing. These findings confirm that drug use is prevalent and associated with negative health effects among EDM nightlife attendees. The nightlife scene is a setting with promising potential to reach a high-risk target group with illicit drug use prevention interventions.
Parental Self-Efficacy to Promote Children’s Healthy Lifestyles: A Pilot and Feasibility Study
Authors: Ruiz-Zaldibar Cayetana , Serrano-Monzó Inmaculada , Lopez-Dicastillo Olga , Pumar-Méndez María Jesús , Iriarte Andrea , Bermejo-Martins Elena , Mujika Agurtzane
Published: April 2021

Positive parenting programs are a key strategy to promote the development of parental competence. We designed a pilot study based on parental self-efficacy to promote healthy lifestyles in their children aged between 2 to 5 years old. In this pilot study, we aimed to assess the effects of a parenting program on parental self-efficacy and parenting styles. Twenty-five parents were allocated into intervention (N = 15) and control group (N = 10). Parents from the intervention group received four group sessions (120 mi per session) to develop a positive parenting, parenting styles and parenting skills regarding to children’s diet, exercise, and screen time, and two additional sessions about child development and family games. Parents from the control group received these two latter sessions. Parental self-efficacy, parenting styles, and meal-related parenting practices were measured before and after the intervention and at 3-month follow-up. Acceptability and feasibility of the program was also measured. Quantitative data were analyzed using the repeat measures ANOVA and ANCOVA tests and the effect size calculation. Content analysis was used to analyse open questions. Positive trends were found regarding parental self-efficacy and the use of authoritative parenting style. Parents also reported a great acceptability of the program getting high satisfaction. According to the feasibility barriers and facilitators aspects were identified. The positive trends founded in this study support the development of parenting programs to promote healthy lifestyle in children.
A Decision-Tree Approach to Assist in Forecasting the Outcomes of the Neonatal Brain Injury
Authors: Neamțu Bogdan Mihai , Visa Gabriela , Maniu Ionela , Ognean Maria Livia , Pérez-Elvira Rubén , Dragomir Andrei , Agudo Maria , Șofariu Ciprian Radu , Gheonea Mihaela , Pitic Antoniu , Brad Remus , Matei Claudiu , Teodoru Minodora , Băcilă Ciprian
Published: April 2021

Neonatal brain injury or neonatal encephalopathy (NE) is a significant morbidity and mortality factor in preterm and full-term newborns. NE has an incidence in the range of 2.5 to 3.5 per 1000 live births carrying a considerable burden for neurological outcomes such as epilepsy, cerebral palsy, cognitive impairments, and hydrocephaly. Many scoring systems based on different risk factor combinations in regression models have been proposed to predict abnormal outcomes. Birthweight, gestational age, Apgar scores, pH, ultrasound and MRI biomarkers, seizures onset, EEG pattern, and seizure duration were the most referred predictors in the literature. Our study proposes a decision-tree approach based on clinical risk factors for abnormal outcomes in newborns with the neurological syndrome to assist in neonatal encephalopathy prognosis as a complementary tool to the acknowledged scoring systems. We retrospectively studied 188 newborns with associated encephalopathy and seizures in the perinatal period. Etiology and abnormal outcomes were assessed through correlations with the risk factors. We computed mean, median, odds ratios values for birth weight, gestational age, 1-min Apgar Score, 5-min Apgar score, seizures onset, and seizures duration monitoring, applying standard statistical methods first. Subsequently, CART (classification and regression trees) and cluster analysis were employed, further adjusting the medians. Out of 188 cases, 84 were associated to abnormal outcomes. The hierarchy on etiology frequencies was dominated by cerebrovascular impairments, metabolic anomalies, and infections. Both preterms and full-terms at risk were bundled in specific categories defined as high-risk 75–100%, intermediate risk 52.9%, and low risk 0–25% after CART algorithm implementation. Cluster analysis illustrated the median values, profiling at a glance the preterm model in high-risk groups and a full-term model in the inter-mediate-risk category. Our study illustrates that, in addition to standard statistics methodologies, decision-tree approaches could provide a first-step tool for the prognosis of the abnormal outcome in newborns with encephalopathy.
Hospitalizations and Treatment Outcomes in Patients with Urogenital Tuberculosis in Tashkent, Uzbekistan, 2016–2018
Authors: Ismatov Bakhtiyor , Sereda Yuliia , Sahakyan Serine , Gadoev Jamshid , Parpieva Nargiza
Published: April 2021

Despite the global shift to ambulatory tuberculosis (TB) care, hospitalizations remain common in Uzbekistan. This study examined the duration and determinants of hospitalizations among adult patients (≥18 years) with urogenital TB (UGTB) treated with first-line anti-TB drugs during 2016–2018 in Tashkent, Uzbekistan. This was a cohort study based on the analysis of health records. Of 142 included patients, 77 (54%) were males, the mean (±standard deviation) age was 40 ± 16 years, and 68 (48%) were laboratory-confirmed. A total of 136 (96%) patients were hospitalized during the intensive phase, and 12 (8%) had hospital admissions during the continuation phase of treatment. The median length of stay (LOS) during treatment was 56 days (Interquartile range: 56–58 days). LOS was associated with history of migration (adjusted incidence rate ratio (aIRR): 0.46, 95% confidence interval (CI): 0.32–0.69, p < 0.001); UGTB-related surgery (aIRR: 1.18, 95% CI: 1.01–1.38, p = 0.045); and hepatitis B comorbidity (aIRR: 3.18, 95% CI: 1.98–5.39, p < 0.001). The treatment success was 94% and it was not associated with the LOS. Hospitalization was almost universal among patients with UGTB in Uzbekistan. Future research should focus on finding out what proportion of hospitalizations were not clinically justified and could have been avoided.
Personality Prototypes in People with Type 1 Diabetes and Their Relationship with Adherence
Authors: Sánchez-Urbano Carmen , Pino María J. , Herruzo Carlos
Published: April 2021

Type 1 diabetes (Dm1) is a chronic endocrine and metabolic disease that affects the whole person and requires active, decisive treatment. However, personality traits may influence a patient’s adherence to treatment guidelines. The objective of this work is firstly to identify the 3 Asendorpf personality prototypes (resilient, undercontrolled and overcontrolled) in a sample of Dm1 individuals and determine whether there are any differences in comparison with a control sample; and, secondly, to study their association with adherence to self-care guidelines using both physiological indicators (HbA1C) and self-report measures. To achieve these objectives, a descriptive cross-sectional study was carried out. The sample comprised 294 participants, of whom 104 were people with Dm1 and 190 were controls. The participants, aged between 14 and 34 years, were classified by their scores in NEO-FFI-R, according to the personality characteristics inherent to Asendorpf’s prototypes. Asendorpf’s 3 prototypical personality patterns were found both in the group of people with Dm1 and in the control sample. These patterns showed different degrees of association with adherence to self-care guidelines for this disease and with psychological health factors. Importance should therefore be attached to the personality traits and Asendorpf prototypes of people with Dm1 when proposing interventions to address medical, psychological, and behavioral aspects.