bluuebunny/crossref_metadata_2025 huggingface dataset:
Direito à alimentação saudável do Povo Iny (Karajá) no período da pandemia de Covid-19
Authors: Pinheiro de Carvalho Suyanne  Magda
Published: January 2024

O presente trabalho discute a garantia do direito à alimentação saudável do povo indígena Iny (Karajá) no período da pandemia da Covid-19. A pesquisa é um estudo de caso, realizado com observação participativa e entrevistas a uma família Iny (Karajá) que mora na Aldeia Hawalorá, uma das três aldeias Iny situada no município de Santa Terezinha – MT. Como principais achados, a pandemia revelou as fragilidades tanto no setor de saúde, quanto na segurança alimentar dos povos indígenas, uma vez que faltou alimento nas aldeias no período do isolamento, conclui também que os sistemas alimentares sustentáveis dessa população estão fragilizados e precisam ser potencializados. O estudo aponta para a necessidade de articulação das políticas de saúde, agricultura e meio ambiente, que possibilitem efetivação de produção de alimentos de forma sustentável nas comunidades indígenas, através do fortalecimento de suas práticas tradicionais que estão cada vez mais esquecidas.
Atendimento de Crianças e Adolescentes Vítimas de Crimes Sexuais como Garantia de Direitos Humanos
Authors: Reis Lima da Silva Dieise , Leão Marcelo Franco
Published: January 2024

A violência sexual envolvendo crianças e adolescentes é um assunto degrande complexidade. Em razão disso, surgem grandes desafios tanto na identificação,quanto no tratamento dos casos, o que exige um atendimento especializado e integradopor parte dos órgãos da rede proteção, mais especificamente a segurança pública, pormeio da polícia judiciária civil. Pensando nisso, este estudo teve por intuito demonstrarcomo acontece o atendimento de crianças e adolescentes vítimas ou testemunhas decrimes sexuais em uma Delegacia de Polícia do interior do estado de Mato Grosso.Quanto à metodologia utilizada neste estudo, trata-se de uma pesquisa qualitativa,iniciada pela revisão de literatura, na qual foram utilizadas doutrinas e artigospublicados em jornais, revistas jurídicas e científicas, além do ambiente virtual(internet), seguida da coleta de dados a campo. Para isso, no segundo semestre de 2022,foram realizadas conversas informais e entrevistas com alguns servidores da delegaciaconsultada, na intenção de verificar qual o protocolo aplicado durante o atendimento decrianças e adolescentes vítimas ou testemunhas de crimes sexuais. A análise dos dadoscoletados permite considerar que nessa unidade policial não é realizado o mecanismo daescuta especializada, haja vista não ter pessoal qualificado nem tampouco localapropriado para isso, contudo, os demais protocolos são seguidos. Logo, essainvestigação buscou dar apontamentos para um atendimento mais humanizado paraessas vítimas, assegurando dessa maneira a preservação dos seus direitos fundamentais.
Perfil do doador de sangue na Unidade de Coleta e Transfusão de Porto Alegre do Norte-MT: Garantia de Direitos
Authors: Pereira Siglia Maria
Published: January 2024

A doação de sangue é uma atividade fundamental para o bem-estar da sociedade, pois através dela é possível salvar vidas ao proporcionar um tratamento adequado às pessoas que necessitam de transfusões por agravos à saúde. No entanto, é importante levar em consideração que essa prática está intrinsecamente relacionada aos direitos humanos, uma vez que assegura a todas as pessoas o direito à saúde e à vida. Trata-se do resultado parcial de um estudo de cunho teórico-reflexivo, contendo informações relacionadas ao processo de doação de sangue através da verificação de dados que constituem os elementos do relatório HEMOPROD, a fim de caracterizar o perfil epidemiológico do doador. Constitui-se de um estudo de cunho observacional e transversal em caráter quantitativo, realizado na Unidade de Coleta e Transfusão do município de Porto Alegre do Norte, estado de Mato Grosso, durante 2017 a 2022. Os registros dos tipos sanguíneos apontam para uma predominância do tipo O + com 2378 doadores e o tipo AB- com apenas 42 doadores. Os indivíduos do sexo feminino com mais de 29 anos representam uma significativa predominância entre os doadores sangue, principalmente em 2018, período com maiores números de doação. Foi possível identificar as condições de inaptidão clínica, como:  malária, hepatite, IST 's, anemia, hipertensão e outras causas. Como um direito à saúde e à vida, é importante que as pessoas sejam incentivadas a doar sangue regularmente e que haja disponibilidade de bancos de sangue para atender às necessidades dos pacientes.
Pegadas
Authors: Barros José D'Assunção
Published: January 2024

Poema no qual o eu-lírico expressa uma mágoa amorosa, a partir da metáfora de que seu coração foi pisado pela amada
Futuromundo
Authors: Ferreira da Cunha Nathalia
Published: January 2024

A presente obra é parte da produção final da tese de doutorado intitulada "RESSIGNIFICAÇÃO DA POLÍTICA NACIONAL DE RESÍDUOS SÓLIDOS EM PROJETOS DE EDUCAÇÃO AMBIENTAL DO CENTRO DE EDUCAÇÃO AMBIENTAL DE RIO DAS OSTRAS-RJ", e com "O futuromundo" trago à todos os leitores à reflexão da sociedade contemporânea frente aos danos observados na atualidade e a necessidade de se repensar o futuro frente aos padrões de consumo.
Formula E=mc2 as a Property of a Spin Vortex in the Physical Vacuum. The Force of Inertia
Authors:   The State University of Management, Moscow, Russia, Boldyreva Liudmila Borisovna
Published: January 2024

The aim of this work is to show that in well-known expression Е=mc2 symbols m and E denote respectively the mass and energy of spin vortex (of photon or virtual photon) in the physical vacuum, and the energy may be written by expression: E = ℏω, where ℏ is the Planck constant, ω is the precession frequency of spin in the spin vortex. For this purpose, the properties of spin vortex (spin, mass, electric dipole moment) are analyzed. Based on the conducted investigation, the expression for the force of inertia of a moving body is deduced, and it is proven that experimentally observed change in the weight of body during its rotation can be accomplished by the force of inertia. It is shown that the mass connected with the motion of quantum object is formed in a virtual photon like the rest mass of quantum object is formed in a photon, and this formation is carried out by pseudomagnetic interaction
Avaliação de Desempenho de Recursos Humanos no Setor Público
Authors: Leal Guimarães Duanne Emanuel , Ribeiro Bitencourt Iago , Sausen Soares Cristiano
Published: January 2024

O artigo tem por objetivo analisar as características do campo de estudos relacionado à avaliação de desempenho de recursos humanos no setor público e suas oportunidades de pesquisa. Propõe uma revisão bibliométrica realizada com o auxílio do Knowledge Development Process-Constructivist (ProKnow-C). A análise bibliométrica das variáveis propostas a partir do Portfólio Bibliográfico (PB) aponta como principais achados: (i) a mudança de foco da medição para a gestão de desempenho; (ii) 21% dos trabalhos do PB não utilizaram teorias de base; (iii) destaque para domínio contextual psicológico da avaliação de desempenho; e (iv) foco nos estágios de desenho e implantação do ciclo de vida dos sistemas de avaliação de desempenho (SAD). A pesquisa contribui ao fornecer subsídios aos pesquisadores e gestores públicos sobre as oportunidades de pesquisa e evolução da avaliação de desempenho de recursos humanos no setor público.
Sartre’s Ontology and its implications on Education in Kenya: Critical Reflections on Bhadra’s Phenomenology and Existentialism
Authors: Afubwa Peter , Anne Njoki , Kauka Elvis Omondi
Published: January 2024

Jean Paul Sartre, a French philosopher, was a prolific author of over 50 literary works. Some of his Philosophical essays include; The Transcendence of the Ego (1936), Imagination: A Psychological Critique (1936), Sketch for a Theory of the Emotions (1939), The Imaginary (1940), Being and Nothingness (1943), Existentialism and Humanism (1946), Existentialism and Human Emotions (1957), Search for a Method (1957), Critique of Dialectical Reason (1960, 1985), Notebooks for Ethics (1983) and Truth and Existence (1989). Sartre is considered to be the first Philosopher to use the term existentialism as a philosophical system. Existentialism in education is a teaching and learning philosophy that focuses on the student’s freedom and agency to choose their future (Ginny, 2012). Sartre first used it to describe his life and that of the postwar literary and philosophical output of his associates. Sartre argued for the different themes across his literary works, yet the bottom line of his thought was not only based on his ‘lived-experiences’ but also his view of reality, better considered as Sartre’s ontology. This paper therefore discussed Sartre’s ontology and its implication to educational practices and policies in Kenya.
Food Shortage: Filipino – American Cooperation Against Famine, 1900-1910
Authors: Soquino Sarreal D.
Published: January 2024

This study has reviewed the ability of the Filipino farmers in the island of Panay, part of Central Philippines, confront the food shortage as they sought for abundant harvest and ensure the steady supply of food needed by the hard-pressed population. This study investigates how the 2nd Philippine Commission and the local population averted the outbreak of famine in the island of Panay. It traces the existing indicators that famine may break out and become a potential threat to the population of the said island at the advent of the 20th century. This paper also probes how the farming communities and their provincial governments addressed the problem of food shortage, and stresses the significant role of three colonial agencies – the Bureau of Agriculture, Bureau of Public Works, and Bureau of Public Health – which the Philippine Commission utilized in its campaign against food shortage.
Post-Pandemic Business Recovery Experiences of Samal Island Beach Resorts Owners: A Hermeneutic Phenomenological Inquiry
Authors: Dalagan Alezandra Marzeil A. , A. Sy, Jr. Melecio
Published: January 2024

The tourism industry globally was primarily affected by the covid-19 pandemic travel restrictions due to the suspension of tourism activities including the tourism of small islands like the Island Garden City of Samal. The purpose of this study is to find the meaning of the experiences, coping mechanisms, and insights of the resort owners, managers, and local government tourism workers. This is a qualitative study using a phenomenological approach to understand the recovery experiences of island beach resorts. There were six purposively chosen owners and managers of beach resorts in Samal underwent in-depth interviews, while six participants took part in a focus group discussion. Thematic analysis was applied to the gathered information. The study found that the resorts were able to re-operate gradually and business continuity was manifested. The most relevant theme presented was Tourism business renovation. Participants seized the pandemic as an opportunity to upgrade resort facilities, enhance amenities, and improve service quality, providing job stability for employees through construction projects.
Evolution of Tourism through Travel Agencies: A Case Study on Bangladesh
Authors: Tahmina Tahmina , Muhsina Kamarun
Published: January 2024

The aim of this research paper is to examine the role of travel agencies in the advancement of tourism in Bangladesh. Travel agents are currently assuming a significant role in facilitating this relationship. The aforementioned entities engage in the production of various package tours, distribution of these packaged products, and promotion of tourism in Bangladesh to potential tourist clientele. However, the travel agents in Bangladesh are limited in their ability to fulfil their job to its fullest degree. This is mostly due to the small size of their organizations, insufficient money, a shortage of skilled professionals, a lack of government policy support, and several other restraints that they encounter. It is imperative to address these issues and promptly implement appropriate measures to enhance the performance of travel agencies and facilitate the desired growth of the tourism sector in Bangladesh.
Post Concession and Users’ Perceptions of Seaports in Nigeria
Authors: Obi Abang , P. Ologunwa O.
Published: January 2024

Seaports in Nigeria are gradually moving away from being publicly operated to engaging the private sectors in terminal operations through concession contracts. This paper examined the Users’ Perceptions of the Pre and Post Concession of Nigerian seaports. The study employed qualitative and quantitative research method with data spanning between 1994 and 2019. The results showed that; the performances of Pre concession was perceived poor by the users in Onne seaport (mean = 1.84) while it was graded good at Post concession (mean = 3.49). Port users Perceived the performances of Apapa seaport at Pre concession as poor (mean = 1.88) while it was perceived as good at Post concession (mean = 3.11). Port users Perceived the performances of Warri port at Pre concession as poor (mean = 1.75), while it was perceived good at Post concession (mean = 3.09). However Port Users in all the ports perceived level of corruption lower at the pre concession (mean = 1.64) than the post concession (mean = 2.87). In all the selected ports, users rated relevance of ICT in cargo clearance as most perceived good while the satisfaction of the port services was perceived least at concession (mean =3.64, 2.75). The paper concludes that there was an improvement in the provision of adequate & modern critical infrastructures at concession. The relevance of ICT in cargo clearance improved at concession as well as the managerial competency of the terminal operator. However, at the period of this paper, levels of corruption were perceived positive and significant at concession.
Mathematical Analysis on Dispersion Relation of Rayleigh Wave for an Initially Stressed Magneto-Poroelastic Material with Corrugated and Impedance Boundary
Authors: Anya Augustine Igwebuike , Uche Ugochukwu David , Nwachioma Christian
Published: January 2024

This study showcases the Mathematical modelling of elastic surface waves and the analysis of dispersion relations of Rayleigh-type of wave in an initially stressed homogeneous porous magneto-elastic material having corrugated and impedance boundary exhibitions. Adoption of the classical harmonic method of wave analysis, non-dimensionalization of the resulting equations of motion, and corrugated-impedance boundary conditions produced by the modeled problem are also captured. The dispersion equation was analytically and graphically presented. Effects of the contributing physical quantities, such as impedance and corrugated boundary parameters, on Rayleigh waves for the chosen material are analyzed. The magnetic field’s influences and the wavenumber associated with the corrugated boundary surfaces on the material increase the dispersion relations of the Rayleigh wave profile on the material. In addition, we noted that the dispersion relations of the wave increases for increasing phase velocity and some parameters of voids. Also, a void parameter triggered a decrease on the dispersion profile of the Rayleigh wave when increased while noting some uniform exhibitions from other voids coefficients. This work holds the potential to provide more insights into studies involving displacement distributions in earthquake sciences, stress-strain analysis in Structural Engineering materials, among others.
 
Received: 17 October 2023 | Revised: 14 December 2023 | Accepted: 28 December 2023
 
Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
 
Author Contribution Statement
Augustine Igwebuike Anya: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision, Project administration; Ugochukwu David Uche: Methodology, Software, Validation, Formal analysis, Investigation, Resources, Writing - original draft, Writing - review & editing, Visualization; Christian Nwachioma: Methodology, Software, Validation, Investigation, Resources, Writing - original draft, Writing - review & editing, Visualization.
Study on the simultaneous determination of bixin and norbixin in foods by high-performance liquid chromatography
Authors: Vu Thi Trang , Luu Thi Huyen Trang , Le Thi Thuy , Nguyen Nhu Thuong , Vu Thi Nhat Le , Do Doan Phuong Loan , Ngo Thuy Linh , Nguyen Thi Anh Huong , Le Thi Hong Hao ,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   Hanoi University of Pharmacy, Hanoi, Vietnam,   Hanoi University of Pharmacy, Hanoi, Vietnam,   University of Science, Vietnam National University, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam
Published: January 2024

Bixin and norbixin are two types of apocarotenoids that can be extracted from the seeds of cashew nuts (Bixa orellana). They are the main components of annatto, a natural food coloring agent, which is widely used in the food industry to impart yellow and orange-red hues to various food products. The objective of this study was to develop a method for the simultaneous determination of bixin and norbixin in different food samples using high performance liquid chromatography (HPLC-PDA). The samples were extracted with ethanol by ultrasonic vibration at room temperature for 20 minutes. The extracted samples were then analyzed by HPLC-PDA using XBridge C18 chromatography column (150 mm x 4.6 mm; 5 µm), and isocratic elution with a mobile phase consisting of 0.5 % formic acid in water: MeOH (15:85, v:v) at 450 nm detection wavelength. The method showed good specificity, high correlation coefficients (R2 > 0.9999) for the calibration curves, acceptable repeatability (1.9-4.2% for bixin and 4.1-5.9% for norbixin), satisfactory recovery (96.0-107% for bixin and 95.0-109% for norbixin), low limits of detection (LOD) (0.17-0.5 mg/kg for both bixin and norbixin), and low limits of quantification (LOQ) (0.56-1.31 mg/kg for both bixin and norbixin). The method was successfully applied to the simultaneous determination of bixin and norbixin in 35 food samples. The results showed: concentrations ranging from 736 mg/100g to 5911 mg/100g (bixin) and from 8.91 mg/100g to 51.9 mg/100g (norbixin) for raw material samples and from 5.85 mg/kg to 490 mg/kg (bixin) and 0.83 ng/kg to 8.02 mg/kg (norbixin) for food samples.
Quantification of lactoferrin in dietary supplements using a Heparin affinity clean-up column by HPLC PDA detector
Authors: Nguyen Quang Hung , Tran Ngoc Lan , Kieu Van Anh , Doan Thu Thuong , Nguyen Van Khoa , Pham Thanh Mai , Thai Nguyen Thao Linh , Nguyen Thi Van Anh , Cao Cong Khanh , Mac Thi Thanh Hoa ,   National Institute for Food Control, Hanoi, Vietnam,   Vietnam University of Traditional Medicine, Hanoi, Vietnam,   Hanoi University of Science, Vietnam National University, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   Hanoi University of Pharmacy, Hanoi, Vietnam,   Hanoi University of Pharmacy, Hanoi, Vietnam,   Vietnam University of Traditional Medicine, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam
Published: January 2024

The use of dietary supplements containing lactoferrin is a growing trend. As a result, there is a need for a simple and reliable analytical method to determine the content of lactoferrin in these supplements to ensure food quality. In this study, an HPLC method was developed and validated for determining lactoferrin in dietary supplements using a HiTrap Heparin clean-up column in combination with HPLC. The study involved selecting optimal conditions for extracting lactoferrin from the sample matrix, followed by chromatography conditions using a C4 column (150 mm × 4.6 mm, 3.5 µm). The limit of detection (LOD) and limit of quantification (LOQ) were determined, with the achieved values being 1.2 mg/100g and 4.0 mg/100g, respectively. The method has shown good recovery (99.5–103.4%) and precision (RSD 1.76–3.44%), meeting the method performance requirements outlined in AOAC SMPR 2020.005. The validated method was applied to determine the contents of lactoferrin in dietary supplement samples.
Simultaneous determination of capsanthin and capsorubin in foods by high-performance liquid chromatography using PDA detector
Authors: Le Thi Thuy , Vu Thi Trang , Do Truc Quynh , Le Viet Ngan , Nguyen Quang Huy , Hoang Thi Lan Anh , Le Thi Hong Hao ,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam,   University of Medicine and Pharmacy, Thai Nguyen University, Thai Nguyen, Vietnam,   Military Institute of Preventive Medicine, Hanoi, Vietnam,   National Institute for Food Control, Hanoi, Vietnam
Published: January 2024

A high-performance liquid chromatography method with a photodiode array detector (HPLC-PDA) was developed for the simultaneous determination of Capsanthin and Capsorubin in food. These are the two main carotenoids responsible for the red color found in Capsicum annuum and lily (Lilium). Analytes were extracted by ultrasonic vibration method with solvent of acetonitrile (ACN): ethyl acetate containing 0.1% butyl hydroxytoluene (BHT) (1:1, v/v) at a temperature of 40oC for 20 minutes. The sample extract solution was determined by HPLC–PDA with the following conditions: InterSustain C18 column (250 mm x 4.6 mm; 5 µm), mobile phase consisting of a 5 mM ammonium acetate solution, ACN, MeOH, and water following with gradient program, detection wavelength at 450 nm. The method has good specificity, the calibration curve of Capsanthin and Capsorubin has R2 > 0.9997 and the repeatability and recovery meet AOAC requirements. The limit of detection (LOD) and limit of quantification (LOQ) were 0.20 mg/kg and 0.67 mg/kg, respectively. The method was applied to simultaneously determine Capsanthin and Capsorubin in 35 different food products including chili powder, spices, soft drinks, canned products, confectionery, ice cream, and cheese. Capsanthin was detected with a content of 10.5-15.8 mg/kg in chili powder and 3.86-9.78 mg/kg in spices, capsorubin was detected with a content of 2.86-3.92 mg/kg in chili powder and 0.76 -1.64 mg/kg in spices.
Caso de hanseníase virchoviana subpolar tratado com a PQT/OMS
Authors: OPROMOLLA Diltor V.A. , FLEURY Raul Negrão , TABORDA Paulo Rogério O.
Published: January 2024

Os autores apresentam um caso de hanseníase virchoviana subpolar tratado com a PQT/OMS. Após a alta com 2 anos de terapêutica, apresentou reação tipo Eritema nodoso hansênico, intensa, com dores articulares, edema nas extremidades e lesões ósseas múltiplas. Analisam a literatura e comentam a incidência pouco freqüente de lesões ósseas especificas, as características radiológicas e histopatológicas das mesmas, e a raridade dos casos com lesões disseminadas No caso estudado encontraram infiltrado dimorfo na biópsia óssea acompanhado de focos supurativos característicos de uma reação tipo ll,que vieram contribuir para a classificação do paciente como virchoviano subpolar e justificar o aparecimento das lesões. Discutem a gênese da destruição óssea durante o processo reacional e lamentam a falta de mais estudos bem controlados sobre as lesões ósseas na hanseníase que poderiam contribuir para uma melhor compreensão da fisiopatologia da moléstia.
Recaídas en Hanseniasis: experiencia personal
Authors: Aguas José Terencio de Las
Published: January 2024

En un total de 451 pacientes tratados con Monoterapia con Sulfonas, se han observado 31 recaídas, 15 de ellas de forma dimorfa. El intervalo de tiempo entre inactividad y recaídas oscila entre 6 y 39 anos. En los enfermos tratados con Multiterapia se ha observado un único caso.
Comparação de dois esquemas poliquimioterápicos com duração fixa em hanseníase Multibacilar
Authors: Gallo Maria Eugenia Noviski
Published: January 2024

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Early detection os subclinical leprosy
Authors: Gillis Thomas P.
Published: January 2024

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A hanseníase após a cura
Authors: Opromolla Diltor Vladimir Araújo
Published: January 2024

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EROSIVE PROCESSES IN BURACO FUNDO’s GULLY, MIDWEST OF (RS) / PROCESSOS EROSIVOS NA VOÇOROCA DO BURACO FUNDO, CENTRO-OESTE DO RS
Authors: GABRIEL SCHNORR GIORGE , AUGUSTO VOLPATO SCCOTI ANDERSON
Published: January 2024

Entre as formas decorrentes de erosão, a voçoroca é a qual possui os maiores impactos e destruição. O presente trabalho objetiva identificar e mapear os processos erosivos acelerados na voçoroca do Buraco Fundo, Centro-Oeste do Rio Grande do Sul. Para isso, organizou-se o trabalho partindo de uma visão sistêmica e um banco de dados georreferenciado foi elaborado com base em trabalhos de campo e bases cartográficas. O processo referido se desenvolve principalmente em um espesso manto de materiais alterados e inconsolidados, cuja estrutura e textura resultam em processos de solapamento de bordas, caracterizada como erosão remontante, tendo a intervenção antrópica como condicionante dos processos. A proposição deixada é o isolamento da área da voçoroca, principalmente onde há a sua reativação, por meio das alterações do uso da terra e práticas não efetivas de controle.
Some winter active flies from snow and caves of Vârghiș, Romania
Authors: Kurina Olavi , Dénes Anna , Dvořák Libor , Dvořáková Kateřina , Oboňa Jozef , Roháček Jindřich , Manko Peter
Published: January 2024

This paper attempts to fill the gaps in knowledge about the biodiversity of some winter-active fly families from snowfields and caves in Vârghiș, Romania. A total of 15 fly species were recorded from caves and 9 species from snowfields. Exechiopsis (Exechiopsis) pseudindecisa Lastovka et Matile, 1974 and Rymosia placida Winnertz, 1863 from caves and Mycetophila mitis (Johannsen, 1912) (all Mycetophilidae) from snow represent the first records for Romania. Habitus photographs of these three species are provided.
Hepatobiliary complications in autosomal recessive polycystic kidney disease
Authors: Brndiarová Miroslava , Haláčová Nikola , Kozár Marek , Demeter Michal , Schnierer Martin , Havlíčeková Zuzana
Published: January 2024

Súhrn: Úvod: Polycystická autozomálne recesívna choroba obličiek (ARPCHO) je raritná, značne fenotypovo variabilná primárna cíliopatia. Poškodenie obličiek a pečene sú typickými prejavmi a prognóza ochorenia závisí od ich progresie v čase. Hlavným extrarenálnym prejavom je fibrocystická prestavba pečene, ktorá sa prejavuje intrahepatálnou portálnou hypertenziou a cholangitídou. Metódy: Retrospektívne zhodnotenie výskytu a vývoja hepatobiliárnych prejavov ochorenia. Výsledky: Do súboru bolo zaradených 8 detí s polycystickou autozomálne recesívnou chorobou obličiek. Poškodenie obličiek a hypertenzia boli prítomné u všetkých detí v súbore. Hepatobiliárne prejavy boli popísané u 5 detí (62,5 %). Trombocytopénia predchádzala splenomegáliu v časovom období jeden rok. Súčasťou výsledkov sú aj tri kazuistiky. Záver: Pacienti s ARPCHO by mali byť cielene vyšetrení so zameraním na posúdenie hepatálnych prejavov ochorenia. Kľúčové slová: autozomálne recesívna polycystická choroba obličiek – fibrocystická prestavba pečene – ezofágové varixy – trombocytopénia Summary: Introduction: Autosomal recessive polycystic kidney disease (ARPKD) is a rare, phenotypically variable primary ciliopathy. Kidney and liver damage are typical manifestations, and the prognosis of the disease depends on their progression over time. The main extrarenal manifestation is fibrocystic rebuilding of the liver, which is manifested by intrahepatic portal hypertension and cholangitis. Methods: The aim of the retrospective study was to evaluate the incidence and development hepatobiliary manifestations. Results: Eight children with polycystic autosomal recessive kidney disease were included in the group. Renal damage and hypertension were present in all children. Hepatobiliary manifestations were described in five children (62.5%). Thrombocytopenia preceded splenomegaly by one year. The results also include three case reports. Conclusion: Patients with ARPKD should be examined with a focus on the presence of hepatic manifestations of the disease. Key words: autosomal recessive polycystic kidney disease – esophageal varices – fibrocystic disorder – thrombocytopenia
Evaluation of the association between red cell distribution width (anisocytosis) and degree of liver fibrosis in children with chronic liver diseases
Authors: Dehghani Seyed Mohsen , Bordbar Mahammad Reza , Gashtaseb Mahsa Borjzadeh , Shahramian Iraj , Tahani Masoud
Published: January 2024

Summary: Background: Red cell distribution width (RDW) demonstrates the heterogeneity of red cell volume and is a component of the complete blood count. Recent studies, however, have reported that RDW is associated with increased mortality in many clinical conditions and found that high RDW is associated with an increase in all-cause mortality. Some studies have also reported the association between RDW values and the severity of liver diseases. It has been claimed that elevated RDW values positively correlate with MELD scores in different disease statuses of hepatitis B virus infection. In addition, RDW increased with the worsening of Child-Pugh grade in hepatic cirrhosis. Methods: This study investigated the clinical utility of RDW values for indicating the presence of liver fibrosis in children with chronic liver diseases. We have conducted a retrospective study on 413 patients. We collected demographic, clinical, and laboratory data and pathologic reports of the liver fibrosis stage from the medical record and analyzed them with SPSS. Result: In our study, there was no significant association between the values of RDW and different stages of fibrosis, but the association between the values of RDW and worsening of Child-Pugh score, APRI, RPR, FIB-4, and PELD score was significant. Conclusion: We cannot find any correlation between RDW and the stage of liver fibrosis. Key words: liver – RDW – fibrosis – cirrhosis
Pharmacological characteristics of subcutaneously administered monoclonal antibodies
Authors: Urbánek Karel
Published: January 2024

Summary: Subcutaneous administration is a simple method of parenteral administration with a minimum of possible complications, also suitable for home treatment. Moreover, it can be used to influence the pharmacokinetics of the administered drug. For therapeutically used monoclonal antibodies, it brings several advantages in terms of simplifying treatment and improving patient’s adherence. In addition, it appears that by targeting pharmacokinetic parameters, lower immunogenicity, and achievement of pharmacokinetic-pharmacodynamic targets can be achieved and thus, likely improve treatment outcomes. Key words: monoclonal antibodies – pharmacokinetics – pharmacodynamics – subcutaneous administration
A temporary regulation to manage an impending shortage due to extraordinary prescribing patterns of chloroquines observed during early phase of COVID-19 epidemic
Authors: Kälkner Karl-Mikael , Sundström Anders , Juhasz Haverinen Maria , Nordback Kenneth , Arthurson Veronica , Zethelius Björn , Ljung Rickard
Published: January 2024

Background: Chloroquine and hydroxychloroquine (C/HC) received considerable international media attention due to anticipated treatment effect in COVID-19. This led to increased prescriptions threatening to generate product shortages for patients prescribed within approved indications.

We evaluated effects of a temporary regulation mandating pharmacies to only dispense C/HC prescribed by physicians with defined specialties.

Methods: Data from Region Stockholm, which include 2.4 out of 10 million Sweden’s population, were used. Weekly time trends of prescriptions and requisitions of C/HC by prescriber’s workplace during January to April 2020 were followed.

Results: Numbers of unique individuals with filled prescriptions of chloroquine increased tenfold and of hydroxychloroquine more than threefold from January to March. In the first week of April, filled prescriptions of C/HC dropped. In the later weeks of April, the number of filled prescriptions was back at similar levels as before the SARS-CoV-2 outbreak.

During January and February, specialists in rheumatology accounted for 686 out of all 979 prescriptions dispensed (70.1%) of C/HC. In March, a large proportion of prescriptions dispensed were from specialists not usually prescribing C/HC, and rheumatology accounted for 628 out of all 1,639 prescriptions (38.3%). In April, specialists in rheumatology accounted for 386 out of all 641 prescriptions dispensed (60.0%).

Conclusion: After an observed increase in prescriptions of C/HC, a temporary regulation was introduced on 2nd April 2020 to reduce prescriptions from specialists not usually prescribing C/HC to avoid shortages for patients within approved indications. Subsequently, dispensed prescriptions decreased from April and remained at pre-COVID-19 levels thereafter.
giros del giro afectivo: la centralidad de la vida sensible para teorizar lo social.
Authors: López Sánchez Oliva
Published: January 2024

En este artículo presento un panorama de los aspectos epistemológicos y políticos que propiciaron la construcción del giro afectivo, perspectiva que coloca de manera central a las emociones, sentimientos y afectos para teorizar lo social. Las críticas  de la teoría feminista y entre otras de los años de 1960 hacia los paradigmas racionalistas construidos en la posguerra (after 1945) posibilitaron la inclusión de esas dimensiones soslayadas en las investigaciones socio antropológicas e historiográficas. A partir de un recorrido estratégico que incorpora los giros del giro afectivo señalo algunos atisbos ontológicos y epistemológicos compartidos por distintas aproximaciones. Enfatizo las aporías de los intentos por diferenciar, de manera excluyente, la vida afectivo-emocional y destaco la trascendencia heurística de su incorporación en la investigación por cuanto importa lo que organizan en el mundo social (relaciones) más que por su definición. Se presenta el desarrollo del campo desde una mirada en clave latinoamericana.
Francois Hartog: el comienzo de una trayectoria
Authors: Durán Norma
Published: January 2024

Este ensayo trata de explicar el comienzo de la trayectoria intelectual de François Hartog y, a partir de esto, entender la función que puede tener la historiografía en la actualidad, cuando el “presentismo” consume todo al instante e impide percibir algún horizonte para la disciplina que no sea “el tiempo presente”. A partir de hacer historiografía sobre los libros de Hartog se puede ver cómo elabora sus preguntas y su manera de leer los textos, cuestión que le permitió ir del tema de la alteridad a sus “regímenes de historicidad”. Finalmente, ver que la historiografía implica un cierre epistemológico a partir de la propia historia y que es desde ella misma que ha sido posible pensar la historicidad de la escritura de la historia.
STATISTICAL VALIDATION OF TRIPLE COLOCALIZATION ANALYSIS
Authors: BUONFIGLI Julio , QUINTERO Cristian , SÁNCHEZ Diego , LEIVA Natalia , DAMIANI Maria Teresa
Published: January 2024

Background: in the last decades, colocalization analysis of fluorescently tagged biomolecules has proven to be a powerful approach to studying functional relationships between these biomolecules. However, in many cases, to give this analysis a biological meaning, colocalization coefficients must be tested statistically, comparing them with the colocalization expected by chance. Aim: It addressed the statistical significance of triple colocalization to distinguish real triple colocalization and classify different triple signal scenarios. Methods: we use biological and generated images of triple signal scenarios to contrast seven independent statistical facts with independent statistical tests. Three of these tests correspond to pairwise relationships (double scrambling tests), and the others correspond to triple relationships: single scrambling tests (red, green, and blue scrambling) and the triple scrambling test. The analysis and methodology proposed can be reproduced using the application developed in our laboratory. Results: In the study approach, we found true triple relationships ignored by using traditional methods of computing the statistical significance, while we could reinterpret cases of not significant triple colocalization wrongly considered as significant by traditional methods. Discussion: single scrambling tests can reveal significant triple colocalization for low levels of triple co-occurrence, even when all pairwise relationships were exclusion relationships. Moreover, on the other hand, single scrambling tests can reveal the absence of a significant triple colocalization for high levels of triple co-occurrence, even when all pairwise relationships were significant colocalization. Conclusion: all scrambling tests are useful to classify a specific scenario of a triple relationship. Dynamics like mitosis can be distinguished into their phases by triple signal relationships using these 7 independent statistical tests.
REVIEW OF AIR POLLUTION RESEARCH RESULTS ON THE EXAMPLE OF TBILISI
Authors: KUPATADZE Ketevan
Published: January 2024

Background: Air pollution is one of the significant environmental challenges facing modern humanity. Atmospheric air is polluted with harmful substances emitted from anthropogenic and natural sources. Aim: The presented paper provides an overview of monitoring results conducted in the Capital of Georgia for 2023. Results from air quality monitoring sensors show that particulate matter, sulfur, and nitrogen dioxide represent problematic pollutants in different city areas. Methods: The research was carried out through sensors installed in different districts of Tbilisi. The investigation was carried out within the NATO SPS program project REACT. Results: Atmospheric air pollution was monitored at four stationary sensor sets on K. Cholokashvili, Nutsubidze Street, Chavchavadze Avenues, and the Old Tbilisi area. The results are presented in the article in the form of tables. Discussion: Average indexes of sulfur dioxide and PM particles were observed in all areas. Nitrogen dioxide indices were both low and medium. Conclusions: Based on the data obtained, it can be assumed that the air in most districts of Tbilisi is moderately polluted, and in some cases, the data exceeds the maximum allowable norm. There may be several reasons for this.: 1. Unauthorized slashing of Green islands and massive construction of high-rise residential buildings on their place in Tbilisi. 2. Malfunctioning vehicles, the technical inspection of which has recently been made stringent. However, some vehicles still pollute the air. 3. Emissions produced by mini factories and enterprises.
SOUTHERN JOURNAL OF SCIENCES ANNUAL TRANSPARENCY REPORT
Authors: Pelaez Walter José , Brandini De Boni Luis Alcides
Published: January 2024

ATR 2023. SOUTHERN JOURNAL OF SCIENCES ANNUAL TRANSPARENCY REPORT.
Emerging Threats of Begomoviruses to Cultivating Vegetables, Fruits, and Medicinal Plants and Their Management Strategies in Oman.
Authors: Haq Quazi M. I. , Alnaabi Alzahra A. A. , Al-saadi Marwa S. M. , Alrasbi Fatma H.
Published: January 2024

Begomoviruses, a group of plant-infecting viruses transmitted by whiteflies, have emerged as a significant threat to agricultural productivity in Oman. This comprehensive review examines the escalating challenges posed by begomoviruses to the cultivation of vegetables, fruits, and medicinal plants in the Omani agroecosystem, while also scrutinizing the various management strategies employed to mitigate their detrimental effects. The review begins by elucidating the molecular and ecological aspects of begomoviruses, providing an in-depth understanding of their diversity, evolution, and host interactions. A critical analysis of the impact of begomovirus infections on key crops in Oman follows, exploring the nuances of symptomatology, yield reduction, and economic consequences. Emphasis is placed on the unique agroclimatic conditions in Oman that contribute to the increased vulnerability of crops to begomovirus outbreaks. Subsequently, the review synthesizes the existing knowledge of management strategies, encompassing both traditional and cutting-edge approaches. The efficacy of breeding for resistance, cultural practices, biological control, and emerging biotechnological interventions is evaluated in the context of Omani agriculture. Special attention is given to the socio-economic implications of begomovirus-related crop losses, highlighting the need for integrated and sustainable management practices to safeguard food security and farmer livelihoods. By synthesizing the latest research findings and identifying knowledge gaps, this review serves as a valuable resource for researchers, policymakers, and practitioners involved in agricultural development in Oman. It sets the stage for future research directions and underscores the importance of a multidisciplinary approach in addressing the emerging threats of begomoviruses to the diverse and vital crops cultivated in the Sultanate.
KẾT QUẢ ĐIỀU TRỊ U LYMPHO KHÔNG HODGKIN VÙNG RÌA BIỂU HIỆN TẠI HỐC MẮT
Authors: Nguyễn Ngọc An Nguyên , Đỗ Huyền Nga , Nguyễn Thị Thu Hường
Published: January 2024

Mục tiêu: Đánh giá kết quả điều trị bước đầu u lympho không Hodgkin vùng rìa biểu hiện tại hốc mắt. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả chùm ca bệnh trên 56 bệnh nhân u lympho không Hodgkin vùng rìa biểu hiện tại hốc mắt được chẩn đoán và điều trị tại bệnh viện K từ tháng 3/2019 đến tháng 6/2023. Kết quả nghiên cứu: Nghiên cứu thực hiện trên 56 bệnh nhân. Tuổi trung bình của bệnh nhân là 59,2 ± 12,8; tỉ lệ nam/nữ là 2,3/1. Sờ thấy u là triệu chứng cơ năng thường gặp nhất (21,4%). Khoảng 1/4 bệnh nhân có tổn thương ngoài hốc mắt, chủ yếu là hệ thống hạch (66,6%) và 87,5% bệnh nhân ở giai đoạn I, II. Tỉ lệ đạt bệnh ổn định với các bệnh nhân có chỉ định theo dõi không điều trị do không có triệu chứng lâm sàng sau 12 tháng là 83,3%. Với các bệnh nhân có chỉ định điều trị, tỉ lệ đáp ứng hoàn toàn sau điều trị là 40,6%, trong đó hóa trị kết hợp Rituximab  là 52,4%, với Rituximab đơn trị là 50%, với tia xạ là 0%. Phác đồ R-bendamustin được sử dụng nhiều nhất và đạt được đáp ứng hoàn toàn tốt nhất (60%). Kết  luận: Theo dõi không điều trị mang lại hiệu quả cao. Tỉ lệ đáp ứng với các bệnh nhân có chỉ định điều trị khá tích cực, trong đó hóa trị kết hợp điều trị đích có hiệu quả lớn nhất, đặc biệt là phác đồ R-bendamustin. Điều trị đích hoặc tia xạ cũng là một phương pháp điều trị khả quan với giai đoạn I.
ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA CÁC BỆNH NHÂN HẠ NATRI MÁU TẠI KHOA NỘI TIẾT - ĐÁI THÁO ĐƯỜNG BỆNH VIỆN BẠCH MAI
Authors: Nguyễn Đức Thắng , Nguyễn Quang Bảy , Lê Quang Toàn
Published: January 2024

Mục tiêu: Mô tả đặc điểm lâm sàng, cận lâm sàng của các bệnh nhân hạ Natri máu điều trị nội trú tại khoa Nội tiết- Đái tháo đường Bệnh viện Bạch Mai. Đối tượng và phương pháp: Nghiên cứu mô tả trên 50 bệnh nhân có Natri máu giảm < 135 mmol/L được điều trị tại Khoa Nội tiết, Bệnh viện Bạch Mai từ tháng 1/2023 đến 7/2023. Kết quả: Tuổi trung bình của các bệnh nhân là 65,86 ± 12,71, nhóm tuổi hay gặp nhất là trên 60, tỷ lệ bệnh nhân nam/nữ là 1,4:1. 42% bệnh nhân có hạ Natri máu cấp tính và 58% có hạ Natri máu mạn tính. Nồng độ Natri lúc vào viện trung bình là 121.38 ± 9.07, 40% bệnh nhân có hạ Natri máu nặng < 120 mmol/L, bệnh nhân có nồng độ Natri từ 120-129 mmol/L và ≥ 130 mmol/L lần lượt chiếm 36% và 24%. Tỉ lệ bệnh nhân hạ natri máu không có triệu chứng là 46%, chủ yếu thuộc nhóm hạ Natri máu nhẹ; triệu chứng hay gặp nhất là đau đầu với 46%, thường xảy ra ở nhóm bệnh nhân hạ Natri máu cấp tính, mức độ trung bình đến nặng. Sau 24 giờ điều trị thì nồng độ Natri trung bình là 126.36 ± 6.78 mmol/L và 16% bệnh nhân có Natri máu vẫn < 120 mmol/L. Kết luận: Triệu chứng lâm sàng và cận lâm sàng của bệnh nhân hạ Natri máu rất đa dạng và không đặc hiệu, phụ thuộc nhiều vào mức độ và tốc độ hạ Natri máu cũng như nguyên nhân gây hạ Natri và các bệnh đồng mắc.
ĐẶC ĐIỂM LÂM SÀNG VÀ CÁC TỰ KHÁNG THỂ CỦA VIÊM THỊ THẦN KINH
Authors: Đỗ Thị Hà , Nguyễn Thanh Bình
Published: January 2024

Mục tiêu: Mô tả đặc điểm lâm sàng và các tự kháng thể của bệnh viêm thị thần kinh ở người lớn. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 62 bệnh nhân được chẩn đoán viêm thị thần kinh theo tiêu chuẩn bộ y tế, 2015 tại Trung tâm thần kinh – Bệnh viện Bạch Mai và khoa Nội tổng hợp – Bệnh viện Đại học y Hà Nội từ tháng 7 năm 2022 đến tháng 8 năm 2023. Kết quả: Tuổi trung bình của nhóm nghiên cứu là 45,45 ± 15,28. Tỉ lệ nam/ nữ là 0,55. 100% bệnh nhân có triệu chứng giảm hoặc mất thị lực. 73,1% bệnh nhân có thị lực <5/10. Phù gai thị là đặc điểm tổn thương đáy mắt thường gặp nhất lúc nhập viện với 57,6% trường hợp. Thời gian tiềm sóng P100 kéo dài được ghi nhận ở 69,2% số mắt bệnh. AQP4-IgG có tỷ lệ dương tính cao nhất với 22,6%, tiếp đến là MOG-IgG và Oligoclonal bands với tỷ lệ lần lượt là 11,3% và 8,1%. Bệnh nhân có OCBs dương tính có tỷ lệ tổn thương chất trắng cao hơn so với nhóm OCBs âm tính (23,8% so với 0%). Kết luận: Viêm thị thần kinh có thị lực giảm nặng khi khởi bệnh. Tỷ lệ OCBs dương tính cao hơn ở nhóm có tổn thương chất trắng trên CHT sọ não – hốc mắt so với nhóm không có tổn thương chất trắng.
NGHIÊN CỨU MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ HIỆU QUẢ THU TINH TRÙNG BẰNG PHƯƠNG PHÁP MICRO TESE Ở BỆNH NHÂN KLINEFELTER VÔ TINH
Authors: Phạm Đức Minh , Đoàn Thị Hằng , Trịnh Thế Sơn
Published: January 2024

Mục tiêu: Mô tả một số đặc điểm lâm sàng, cận lâm sàng và xác định tỷ lệ thu tinh trùng bằng phương pháp Micro TESE ở bệnh nhân Klinefelter vô tinh. Đối tượng và phương pháp nghiên cứu: Nghiên cứu được tiến hành trên 25 bệnh nhân Klinefelter vô tinh tại Viện mô phôi lâm sàng Quân đội- Học viện Quân y, Bệnh viện Nam học và hiếm muộn Hà Nội, Trung tâm IVF- bệnh viện Đa khoa Hà Nội. từ tháng 5 năm 2023 đến tháng 9 năm 2023. Kết quả: Thời gian vô sinh trung bình là 5,24±3,93 năm, trong đó tỷ lệ vô sinh nguyên phát chiếm 92%. Thể tích tinh hoàn trung bình bên trái và bên phải lần lượt là 1,35±0,55 mL và 1,43±0,66 mL. Nồng độ FSH, LH, Testosterone trung bình lần lượt là 34,01±22,45 mIU/mL; 22,14 ± 8,88 mIU/mL và 5,46 ± 5,05 ng/mL; Tỷ lệ thu được tinh trùng ở bệnh nhân Klinefelter vô tinh là 24%. Kết luận: Kết luận nghiên cứu cho thấy bệnh nhân KS có những đặc điểm lâm sàng điển hình như thân hình cao lớn, thể tích tích hoàn teo nhỏ; nồng độ hormone FSH, LH tăng rất cao. Tỷ lệ thu được tinh trùng bằng vi phẫu micro- TESE ở bệnh nhân Klinefelter là 24%.
ĐỘ TIN CẬY CỦA NGHIỆM PHÁP 1STST TRONG ĐÁNH GIÁ KHẢ NĂNG GẮNG SỨC Ở NGƯỜI BỆNH PHỔI TẮC NGHẼN MẠN TÍNH
Authors: Nguyễn Thị Thu Hằng , Nguyễn Thành Luân
Published: January 2024

Mục tiêu: Xác định độ tin cậy của nghiệm pháp đứng lên - ngồi xuống trong 1 phút (1STST) trong đánh giá khả năng gắng sức ở người bệnh COPD. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang, phân tích kết quả kiểm tra-kiểm tra lại 1STST ở 122 người bệnh COPD tại 2 thời điểm: lần khám đầu tiên của bệnh nhân và sau 1 tháng tái khám để đánh giá tính lặp lại và độ tin cậy của nghiệm pháp. Ngoài ra, tại mỗi thời điểm, các đối tượng lặp lại bài kiểm tra 1STST sau khoảng thời gian 30p - 1 giờ. Như vậy, mỗi người bệnh sẽ thực hiện tổng cộng 4 lần nghiệm pháp. Kết quả và kết luận: 1STST là nghiệm pháp có độ tin cậy cao để đánh giá khả năng gắng sức ở người bệnh COPD, không có hiệu ứng học tập.