bluuebunny/crossref_metadata_2025 huggingface dataset:
APPLICATION OF THE LIBS TECHNIQUE IN THE DETECTION OF Ti ININDUSTRIAL LIQUID EFFLUENTS
Authors:   Centro de Investigación en Física e Ingeniería del Centro de la Prov. de Buenos Aires (CICPBA – CONICET – UNCPBA)Pinto 366 – Tandil - Prov. Buenos Aires – Argentina. Facultad de Cs. Exactas (FCEx – UNCPBA), Pinto 366 – Tandil - Prov. Buenos Aires. Comisión de Investigaciones Científicas (CIC)., Bayala M.P. , D’Angelo C. ,   Centro de Investigación en Física e Ingeniería del Centro de la Prov. de Buenos Aires (CICPBA – CONICET – UNCPBA)Pinto 366 – Tandil - Prov. Buenos Aires – Argentina. Facultad de Cs. Exactas (FCEx – UNCPBA), Pinto 366 – Tandil - Prov. Buenos Aires. Comisión de Investigaciones Científicas (CIC).
Published: October 2022

In the graphic and textile industries, liquid effluents are generated from the dyes used in the different processes. In these effluents, a heavy metal of great interest, such as Titanium (Ti), is found. This element is not currently contemplated in the environmental legal framework in Argentina, and there are no known diagnostic techniques that are responsible for its measurement. This work studied the feasibility of applying the Laser-Induced Breakdown Spectroscopy (LIBS)technique for detecting Ti in industrial effluents. In the assembly of samples, a possible stabilization method was established for their final disposal, considering the encapsulation in cement for construction. Based on this, four samples were assembled with Portland cement with the addition of ashes, obtained from subjecting the effluents of a graphic industry to a series of physicochemical processes. For a possible quantification process by LIBS, the thin plasma model was proposed, which established the best post-breakdown and integration times for registering the 521.04 nm line ofTi I. As the study’s final results, apost-breakdowntime was 35μs and an integration time of 300 ns. With this, it is intended to optimize the measurement parameters for the analysis and calculation of concentrations, thus promoting the use of the LIBS technique as feasible for this type of measurement.
X-RAY MICROTOMOGRAPHY TO CHARACTERIZE THE ROOT CANAL VOLUME EXTRACTED IN ENDODONTIC INSTRUMENTATION
Authors:   Facultad de Matemática, Astronomía, Física y Computación (FAMAF), Universidad Nacional de Córdoba (UNC),Córdoba, Argentina. Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes de Rayos X (LIIFAMIRx⃝) - FAMAF -Universidad Nacional de Córdoba, Argentina, Gilli R. , Mattea F. ,   Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes de Rayos X (LIIFAMIRx⃝) - FAMAF -Universidad Nacional de Córdoba, Argentina. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), CONICET, Córdoba, Argentina. Departamento de Química Orgánica - Facultad de Ciencias Químicas (FCQ) - UNC, CONICET, Martin G. ,   Carrera de Especialización de Endodoncia, Facultad de Ciencias de la Salud, Universidad Católlica de Córrdoba, Argentina. Carrera de Especialización de Endodoncia, Facultad de Odontología, Universidad Nacional del Nordeste, Argentina. Cátedra de Endodoncia, Facultad de Odontología, Universidad Nacional de Córdoba, Argentina., Valente M. ,   Facultad de Matemática, Astronomía, Física y Computación (FAMAF), Universidad Nacional de Córdoba (UNC),Córdoba, Argentina. Laboratorio de Investigación e Instrumentación en Física Aplicada a la Medicina e Imágenes de Rayos X (LIIFAMIRx⃝) - FAMAF -Universidad Nacional de Córdoba, Argentina. Instituto de Física E. Gaviola (IFEG), CONICET-UNC. Centro de excelencia en FÍsica e IngenierÍa en Salud (CFIS) - Universidad de La Frontera, Temuco; Chile
Published: October 2022

During the last decades, the analytical techniques of X-ray absorption contrast imaging have systematically gained greater relevance, mainly due to the ability to attain non-destructive exploration of the sample interior. The significant improvement in spatial resolution offered by X-ray micro-tomography, as compared to conventional computed tomography, has motivated its insertion in many biomedical fields, among which dentistry stands out. Particularly, for endodontics, microCT appears as a method of remarkable potential interest to study procedures involved in root canal treatments, where one of the main needs is the anatomical characterization of the root canal in the teeth. The present work reports on the adaptation of the microCT equipment of the LIIFAMIRx⃝laboratory at the E. Gaviola Physics Institute, CONICET and UNC, thus allowing to acquire of radiographic images of dental samples of interest, to be later used in the implementation of algorithms, intended to tomographic reconstruction and volume segmentation. As a result, radiographic images of premolar teeth were obtained with good contrast between the different materials present, and three-dimensional representations, whose visualization is comparable with the real samples. Moreover, it was possible to characterize the root canal volume of the tooth both in its natural form and after having undergone the instrumentation process in which the pulp tissue is extracted.
LARGE AMPLITUDE ALFVÉN WAVES IN PARTIALLY IONIZED PLASMAS
Authors:   Facultad de Ciencias Astronómicas y Geofísicas – Universidad Nacional De La PlataPaseo del Bosque s/n – (1900) La Plata – Prov. Buenos Aires – Argentina, Sallago P.A.
Published: October 2022

In this paper it is analyzed the propagation of large amplitude Alfvén waves in partially ionized plasmas (PIP) when electronic pressure, Hall and ambipolar terms of Ohm’s law are taken into account. Instead of linearizing and developing the perturbation in monochromatic waves, it is proposed that the perturbation satisfy the Alfvén wave’s conditions. As a result, a solution is found that in the fully ionized limit, it coincides with Sallago and Platzeck solution for Alfvénwaves in Hall magnetohydrodynamics (doi:10.1029/2003JA009920 ). Furthermore, if electronic pressure and Hall terms are null, in the linearized limit, the damping is equal to the one described by De Pontieu, B. Martens, P. C. H. and Hudson, H. S. (DOI = 10.1086/322408), if one imposes that the plasma is a perfect conductor.
Applications of Noble Nanomaterials in Ensuring Food Safety: A Review of Recent Developments
Authors: Mitra Kamala
Published: October 2022

Compounds derived from natural sources, as well as industrial and agricultural waste, are examples of food contaminants. Food contaminants found naturally are mostly of microbiological origin, including pathogenic organisms and some other fungal and bacterial toxins. Food is among the most significant priorities for public security because it is one of the most basic components of living organisms. As a result, precautions are needed to make sure that foods are exempt from contaminants that enter the food supply via food handling, manufacturing, and dispersion. At the moment, people are increasingly concerned with the accuracy, convenience, and efficiency of food quality and safety testing. On the other hand, many traditional detection methods have drawbacks such as inconvenient operation, interference factors, and long detection times. Nanomaterials can also be used to monitor the lifespan of preserved foods. These can be developed to fluoresce when exposed to food pathogens, chemicals, or contaminants, acting as a sensor for detecting small traces of contaminants. As a result, functionalized nanomaterials with higher selectivity and sensitivity, such as pesticides, veterinary drugs, heavy metals, additives, and synthetic pigments, pathogenic bacteria, and mycotoxins, are widely used in food detection. This paper looks into how noble nanomaterials that can be placed precisely can be used to check the quality and safety of food.
Micelles and Reverse Micelles: a Fascinating Micro-reactor
Authors: Debnath Sisir
Published: October 2022

Reactions in micro-heterogeneous systems have been found to be of great interest in the past few decades. Two such micro-heterogeneous aggregates are micelles and reverse micelles, which are formed by surface active agents or surfactants. In numerous chemical reactions, the use of these systems as microreactors increases the rate of the reaction up to 10-100 folds. This chapter will be concentrated on micelles and reverse micelles as catalytic reactors since, in the past few decades, numerous numbers of reactions have been successfully carried out in these systems.
Role of Probiotics on Skin Health
Authors: Chatterjee Shamba , Das Sucheta
Published: October 2022

Like the internal digestive system, the largest organ of our body, the skin, maintains a healthy balance with the natural inhabitants of it. Skin act as a host for several microorganisms (about one million per square centimetre) including different types of bacteria, fungi, and viruses. This microbiome takes active role in the fighting with infection, providing protection against environmental damage, regulation of pH and in keeping the skin hydrated and healthy. Probiotics are live and healthy microorganisms that can be consumed directly to restore the pH levels and the balance in the guts. They act like good bacteria and are important to keep away the “bad” bacteria from multiplying in different organ of human body. They can also be applied on the skin to restore the skin's ecosystem, pH and immunity. Again, long term exposure to solar radiation may induce UV damaged skin cancer. The utilization of probiotic bacteria in skin cancer research may help in development of new skin cancer prevention and treatment options.
Ethnomedicinal Plants used in Diﬀerent Seasons by Tribals of Asansol Raniganj Coalﬁeld area of West Bengal, India
Authors: Saha Amit
Published: October 2022

Ethnomedicinal plants are very popular among the various tribal communities in India. An ethnomedicinal study was conducted in the Asansol-Raniganj coalfield area of West Bengal during the period 2012–2015. It was found that this area is rich in both mineral resources and ethnomedicinal plant resources. The specific use of the ethnomedicinal plant species and their use in different seasons were noted. The preference for ethnomedicine by the tribals of the Asansol-Raniganj coalfield area strengthens the importance of documentation of these ethnomedicinal plants.
Waste Production in Aquaculture
Authors: Golder Tarikul Islam
Published: October 2022

Due to rivalry resulting from the exploitation of natural resources such as soil and water by other production and development businesses, strengthening aquaculture has emerged as an alternative to boosting aquatic production. However, enhanced waste disposal from aquaculture production systems is required for resilience, as is extra inclusion, such as fish and food, in each cultural region. Polluted aquatic animal products have sparked public outrage and jeopardised the long-term viability of aquaculture operations. The need to boost aquatic product output cannot be overstated, and as a result, cultural systems must be developed that will increase fish production through effective waste management, reducing environmental deterioration caused by marine pollution and ensuring its sustainability. This paper examined the various aspects of waste production from aquaculture, including its sources, components, and management practises in various cultural systems, with a focus on waste production from food, feedstuffs, fertilisers, pesticides, herbicides, and other sources, as well as to identify waste sources, content, and potential hazards to both fish culture and the environment. To ensure the development of enhanced and sustainable aquatic animals, waste management proposals in diverse cultural systems were produced.
CURRENT STATE OF ZOOPLANKTON IN LAKE KULUNDINSKOE, ALTAI TERRITORY DURING THE TRANSGRESSION PHASE
Authors: Vesnina L. V. , Vesnin Yu. A.
Published: October 2022

Lake Kulundinskoye (Kulunda) has been experiencing a downward trend in water salinity over the past three years (from 2017 to 2020) due to an increase in the overall level of moisture in the Altai Territory. In connection with this decrease, the authors observe changes in the composition of the zooplankton in the hypersaline water reservoir. The biota is replenished with brackish-water hydrobionts and the density of various aged individuals of Artemia crustacean and its cysts decreases under conditions of low water salinity.
SOCIAL FUNCTIONS OF SELF-EMPLOYMENT IN MODERN RUSSIA IN THE PERIOD OF PANDEMIC, SANCTIONS, ISOLATION
Authors: Plotnikov I. N.
Published: October 2022

In the article, the author presents a theoretical analysis of the social functions of self-employment in modern Russia during a pandemic, sanctions, and isolation based on a sociological study. The public sector, which has dominated Russia for a little less than a century, has practically given way to the private sector, forcing a new attitude to many facts, such as self-employment. The shadow market of the self-employed turns out for Russia, first of all, in huge, incomparable budget losses. The shadow labour market of self-employed citizens makes representatives of small and medium-sized businesses engaged in similar activities uncompetitive. Self-employment and this is a fact, is inextricably linked with corruption. At the same time, it should be noted that self-employment also performs positive social functions. First of all, self-employment regulates the labour market, does not allow unemployment to grow, and contributes to the survival of a large stratum of our citizens who, for various reasons, due to various life circumstances, found themselves below the poverty line. For several years now, thanks to self-employment in our society, the gap between the poor and the super-rich has been narrowing. Self-employment has played a significant role and will certainly continue to play in the context of the pandemic. The historic events of February 24 this year, related to the special operation in Ukraine, showed that thanks to the efforts of the leader of our country, the Russian army has already gained the ability to ensure the security of our Motherland for many years to come. And this is very important. Tough sanctions, an attempt at an economic blockade, and isolation of our state will allow us to create a model of a new economy based on our strengths. Now the key task for Vladimir Putin is precisely the solution to the issue of economic independence. Self-employment should again play a positive role in the abundance of sanctions and isolation, when tens of thousands, hundreds of thousands, and possibly millions of our fellow citizens have lost and continue to lose their means of subsistence in an instant.
ASSESSMENT OF THE QUALITY AND NUTRITIONAL VALUE OF FIRST GRADE WHEAT FLOUR FROM DIFFERENT MANUFACTURERS
Authors: Naumova N. L. , Betz Yu. A.
Published: October 2022

Despite the sufficient volume of wheat flour production, there are low-grade, falsified products on the consumer market, and flour with low baking properties is also found. In this regard, the purpose of the research was to assess the quality and nutritional value of first grade baking wheat flour from different manufacturers. Studied: organoleptic, physico-chemical, hygienic quality indicators, the content of dietary fiber, mineral elements and vitamins. It was determined that all flour samples in terms of organoleptic indicators met the regulated requirements of GOST 26574-2017, in terms of the amount of pesticides and mycotoxins - the norms of SanPiN 2.3.2.1078-01 and TR TS 021/2011. Flour produced by IP A.A. Mikhailyuta (Omsk region, Kormilovsky district, Pobeditel village) met the requirements of the current standard for first-class products in terms of physical and chemical parameters, was safe in terms of the level of heavy metals within the framework of current regulatory documents, and had a complete macro- and micronutrient composition. Flour produced by JSC “Shadrinsk combine of bread products” (Kurgan region, Shadrinsk) turned out to be unsafe in terms of Pb content, the excess of which was more than 3 times, which is unacceptable. Flour produced by KFH V.V. Malyutov (Ivanovo region, Puchezhsky district, Poperekovo village) did not meet the requirements of GOST 26574-2017 in terms of such indicators as the quantity and quality of gluten, ash content, which may indicate its falsification.
Analisa Pengaplikasian Sistem Rekam Medis Elektronik di Rumah Sakit Setia Mitra
Authors: Gemilang Garis , Kristina Indah , Amarullah Aji
Published: October 2022

From the observation at Setia Mitra Hospital, there have been issues relating to the appliance of electronic medical record (EMR) system. As we all know, the EMR system is currently starting to be a must use system on every hospital. The advancement of technology has shift the use of paper based medical record to EMR. But since it's still newly developed, the application of the system in a newly applied EMR on a hospital is an interesting topic for review. Therefore the writer has chosen this topic to be the main issue on this research. This research main purpose is to find and identify the application of EMR in Rumah Sakit Setia Mitra. For this research, the writer is using a qualitative descriptive research, in which the data colletion is based on the observation done by the writer and also based on interviews that's done with the medical record staffs, and will be analyzed and compared with theories that already exist as the based accepted method on EMR and it's application. The results of the research done by the writers have found that EMR application at Setia Mitra Hospital is not yet been applied according with the theory that's aready exist, and the mains source of this difference is because the EMR on the hospital's information system is still under heavy development. Therefore, the author has suggested that the completeness of the hospital information system must take priority, especeially regarding it's medical record system need to be pushed into an EMR system, so it can create a much more complete, better and robust health information management at Rumah Sakit Setia Mitra
Literature Review on Causes of Claim Return for Inpatients’ Social Security for Health Agency
Authors: Astuti Nina Dwi , Hidayah Andrika Nurul
Published: October 2022

Claim returns for Social Security for Health Agency (BPJS Kesehatan) always become a cliché in the field of health budgeting in the National Health Security (JKN) era. Some studies have examined factors causing claim return; however, the issue has not been figured out yet because every hospital has different troubles. This study was conducted to identify the troubles possibly causing claim returns faced by hospitals. This qualitative study was conducted at a type-C hospital owned by the government in Central Java province. In-depth interviews were conducted with assembling staff, coder, case-mix officer, internal verificatory, and head of the medical record unit. Results showed that claim returns occurred because the hospital information system had not been integrated with e-claim and v-claim apps. The hospital lacked the number of case-mix officers, and old-fashioned information about the INA CBGs payment scheme from the officers including coders, doctors, and other medical officers; the hospital also had inadequate supporting facilities such as echocardiography and endoscopy, and its staff had a lack of work experience and training for coders. Managerial support is tremendously required to solve the issues related to claim returns for BPJS Kesehatan.
Dysphagia in progressive supranuclear palsy: A scoping review protocol
Authors: Flynn Éadaoin , Regan Julie , Radtke Julia , O’Dowd Sean , Walshe Margaret
Published: October 2022

BACKGROUND: One of the most prevalent types of atypical Parkinsonian syndrome is progressive supranuclear palsy (PSP). PSP is associated with early onset of dysphagia which can result in malnutrition, dehydration, and aspiration pneumonia, affecting quality of life and increasing mortality rate. To date, research describing dysphagia in PSP and its impact is scant. OBJECTIVE: The objective of this scoping review is to determine the characteristics of dysphagia in PSP, differences in dysphagia presentation according to PSP subtype, principal methods used for identifying and diagnosing dysphagia and the impact dysphagia has on quality of life in individuals with PSP. METHODS: The proposed scoping review will be conducted in accordance with the JBI methodology for scoping reviews. The Preferred Reporting Items for Systematic Reviews and Meta Analysis extension for scoping reviews (PRISMA-ScR) will be used to guide the reporting of the review (Tricco et al., 2018). Articles completed at any time, which include participants with dysphagia and a clinical diagnosis of PSP will be included. Studies involving participants who have a co-morbidity/morbidities which could cause dysphagia and secondary research will be excluded. Relevant electronic databases, trial registries and grey literature without any date or language restrictions will be searched. Two independent reviewers will assess articles for eligibility and will extract relevant data. CONCLUSIONS: This scoping review will provide important evidence on dysphagia and PSP. It will describe the principal methods used for identifying and diagnosing dysphagia in this population. The results will guide future research in dysphagia and PSP.
Effects of Mindful Awareness Practice (MAP) on Subclinical Depressive and Anxiety Symptoms and General Cognitive Function in Older Adults with Mild Cognitive Impairment: A 5-Year Follow-Up of the MAP-Randomized Controlled Trial
Authors: Ng Ted Kheng Siang , Tan Xiang Ren , Todd Michael , Chen Angela Chia-Chen , Feng Lei , Lu Yanxia , Yu Fang , Kua Ee Heok , Mahendran Rathi
Published: October 2022

Background: Few randomized controlled trials (RCTs) investigated the effects of mindfulness intervention on affective and cognitive symptoms in older adults with mild cognitive impairment (MCI). Furthermore, no RCTs on mindfulness followed participants beyond two years. Objective: To examine the longitudinal effects of a mindful awareness practice (MAP) intervention on depressive, anxiety, and cognitive symptoms in MCI. Methods: In this parallel-arm and assessor-blinded RCT, 55 community-dwelling older adults with MCI were randomized into the MAP or active control, i.e., health education program (HEP). Intervention sessions were conducted weekly for three months and monthly for the subsequent six months. Assessments and follow-up were conducted at baseline, 3-month, 9-month, and 5-year time points. Depressive, anxiety, and cognitive symptoms were measured using the Geriatric Depression Scale-15 (GDS-15), Geriatric Anxiety Inventory-20 (GAI-20), and Mini-Mental State Examination (MMSE), respectively. Linear-mixed models, following the intention-to-treat principle, were used for data analyses. Results: A total of 55 participants aged 60 to 86 (Mean age: 71.3±6 years old) was recruited, with n = 28 allocated to the MAP arm and n = 27 allocated to the HEP arm. Compared to HEP, GDS-15, GAI-20, and MMSE scores did not differ significantly in MAP during follow-ups. Conclusion: Compared to HEP, MAP did not improve affective symptoms nor delay deteriorations in general cognition in community-dwelling older adults with MCI. Compared to our previous findings showing domain-specific improvements in MAP over HEP in attention and memory up to 9 months, this study highlights the importance of examining domain-specificity using detailed cognitive measures in non-pharmacological intervention with MCI.
Hypertensive Aspects of Cardiometabolic Disorders Are Associated with Lower Brain Microstructure, Perfusion, and Cognition
Authors: Hughes Timothy M. , Lockhart Samuel N. , Suerken Cynthia K. , Jung Youngkyoo , Whitlow Christopher T. , Bateman James R. , Williams Benjamin J. , Espeland Mark A. , Sachs Bonnie C. , Williamson Jeff , Cleveland Maryjo , Yang Mia , Rogers Samantha , Hayden Kathleen M. , Baker Laura D. , Craft Suzanne
Published: October 2022

Background: Cardiometabolic disorders (hypertension, diabetes) are key modifiable risk factors for Alzheimer’s disease and related disorders. They often co-occur; yet, the extent to which they independently affect brain structure and function is unclear. Objective: We hypothesized their combined effect is greater in associations with cognitive function and neuroimaging biomarkers of white matter (WM) health and cerebral perfusion in a diverse older adult cohort. Methods: Participants aged 50-85 years received: clinical evaluation, oral glucose tolerance testing, neuroimaging, cognitive testing, and adjudication. Neuroimaging included: T1 (gray [GM]/WM segmentation, regional volumes/thicknesses); FLAIR (WM hyperintensity volume [WMHv]; arterial spin labeling (cerebral blood flow); diffusion tensor imaging (fractional anisotropy [FA]); and neurite orientation dispersion and density imaging (Free Water). Hypertension (HTN) and impaired glucose tolerance (IGT) were staged and cardiometabolic status was categorized (HTN only, IGT only, IGT+HTN, neither). Multivariable linear regression modeled associations with cognitive and neuroimaging measures (covariates: age, gender, race). Results: MRI was available for 478 participants (35% mild cognitive impairment, 10% dementia) with mean age 70±8 years, 74% with HTN, 61% with IGT, and 15% self-identified as Black/African-American. IGT+HTN was significantly associated with cognitive impairment, higher WM Free Water and WMHv, lower FA, and lower GM perfusion compared to neither factor. HTN alone was associated with poorer cognition and lower GM perfusion. Cardiometabolic factors were not associated with GM macrostructure (volumes, temporal lobe cortical thickness) or cognitive status. Conclusion: HTN and its co-occurrence with IGT (HTN+IGT) were associated with lower global cognitive performance and reduced GM perfusion and impaired WM microstructure.
Disease Burden of Spinal Muscular Atrophy: A Comparative Cohort Study Using Insurance Claims Data in the USA
Authors: Mouchet Julie , Roumpanis Spyros , Gaki Eleni , Lipnick Scott , Oskoui Maryam , Scalco Renata S. , Darras Basil T.
Published: October 2022

Background:

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by homozygous deletion or loss-of-function mutations of the survival of motor neuron 1 ( SMN1) gene, resulting in reduced levels of SMN protein throughout the body. Patients with SMA may have multiple tissue defects, which could present prior to neuromuscular symptoms.

Objective:

To assess the signs, comorbidities and potential extraneural manifestations associated with SMA in treatment-naïve patients.

Methods:

This observational, retrospective and matched-cohort study used secondary insurance claims data from the US IBM® MarketScan® Commercial, Medicaid and Medicare Supplemental databases between 01/01/2000 and 12/31/2013. Treatment-naïve individuals aged≤65 years with≥2 International Classification of Diseases, Ninth Revision (ICD-9) SMA codes were stratified into four groups (A–D), according to age at index (date of first SMA code recorded) and type of ICD-9 code used, and matched with non-SMA controls. The occurrence of ICD-9 codes, which were converted to various classifications (phecodes and system classes), were compared between groups in pre- and post-index periods.

Results:

A total of 1,457 individuals with SMA were included and matched to 13,362 controls. Increasing numbers of SMA-associated phecodes and system classes were generally observed from pre- to post-index across all groups. The strongest associations were observed in the post-index period for the youngest age groups. Endocrine/metabolic disorders were associated with SMA in almost all groups and across time periods.

Conclusions:

This exploratory study confirmed the considerable disease burden in patients with SMA and identified 305 unique phecodes associated with SMA, providing a rationale for further research into the natural history and progression of SMA, including extraneural manifestations of the disease.
Sample-motion-synchronized neutron stroboscope at RANS
Authors: Taketani Atsushi , Takanashi Takaoki , Iwamoto Chihiro , Kobayashi Tomohiro , Takamura Masato
Published: October 2022

A sample-motion-synchronized neutron stroboscope is developed using the RIKEN accelerator-based compact neutron source (RANS). When a sample reaches a specified rotation phase, a phase timing signal is generated, triggering a proton pulse at the proton accelerator. A neutron pulse exposes the imaging detector through the sample. By controlling the delay time between the phase signal and the proton pulse timing, the neutron exposure timing is always synchronized with the specific sample rotation phase. A sample rotating at a speed of 1800 RPM is prepared, and clear still images of neutrons are taken.
The impact of kangaroo mother care on work of breathing and oxygen saturation in very low birth weight infants with respiratory insufficiency
Authors: Gable M. , Shaffer T. H. , Locke R. , Mackley A. , Kovatis K.Z.
Published: October 2022

BACKGROUND: Kangaroo mother care (KMC) is defined as prolonged skin to skin care between a mother and infant with the infant lying in prone position on mom’s chest. KMC decreases morbidity and mortality and promotes physiologic stability. The aim of this study is to measure work of breathing (WOB) during KMC in very low birth weight (VLBW) infants on non-invasive respiratory support. METHODS: A prospective observational pilot study was conducted comparing WOB indices during standard care (SC) and KMC. Respiratory inductive plethysmography (RIP) measured WOB indices non-invasively: phase angle and labored breathing index. VLBW infants who were stable on non-invasive respiratory support were randomized to receive RIP measurements during KMC or during SC first. Summary statistics and mixed linear models were used to compare WOB and vital signs. RESULTS: A total of 32 infants were consented for the study, data collection and analysis was completed on 28 infants. There were no significant differences in mean phase angle during KMC or SC (73.5±4.6 SE deg vs 66.8±3.9 SE deg, p = 0.25). No differences in WOB and vital signs were detected. Controlling for respiratory support or randomization/first location did not change the results. CONCLUSION: In this pilot cohort, infants demonstrated no differences in work of breathing indices or oxygen saturation during KMC or SC while receiving non-invasive respiratory support. KMC appears to be safe and well tolerated with no worsened WOB. Larger studies should be performed to confirm our findings.
Premature monochorionic monoamniotic twins have lower lung compliance at birth than matched dichorionic diamniotic twins
Authors: Jordan Brian K. , Bernard Leah , Segel Sally , Go Mitzi D. , Schilling Diane , McEvoy Cindy T.
Published: October 2022

BACKGROUND: Premature infants are born with immature lungs that demonstrate abnormal pulmonary function with differences in passive respiratory system compliance and resistance, and functional residual capacity. To our knowledge, no studies have evaluated differences in neonatal pulmonary function based on the type of twin gestation, or chorionicity. Given the effect of chorionicity on outcomes, we aimed to study the effect of twin type, monochorionic monoamniotic (MCMA) vs dichorionic diamniotic (DCDA), on neonatal early pulmonary function tests. METHODS: In this prospective cohort study, 5 sets of DCDA twins were matched to 5 sets of MCMA twins on gestational age at delivery, latency from antenatal corticosteroid exposure, birthweight, race and gender. Mean values were compared for passive respiratory system compliance and resistance, functional residual capacity, and tidal volume. RESULTS: MCMA infants had a significantly lower compliance (0.64 vs 1.25 mL/cm H2O /kg; p = 0.0001) and significantly higher resistance (0.130 vs 0.087 cm H2O /mL/sec; p = 0.0003) than DCDA infants. Functional residual capacity was lower for MCMA than DCDA infants (17.5 vs 23.4 mL/kg; p = 0.17). Further, 80% of MCMA infants required intubation for surfactant administration compared to 20% of DCDA infants, indicating the clinical significance of these objective measures. CONCLUSIONS: Due to the matched case-control design, causality cannot be established. However, we speculate that these differences in lung function may derive from differential exposure to preterm labor and endogenous maternal corticosteroid exposure. Further study is necessary to establish the true causal relationship.
Workplace accommodations during the COVID-19 pandemic: A scoping review of the impacts and implications for people with disabilities
Authors: Fuentes Kristina , Lindsay Sally
Published: October 2022

BACKGROUND: The COVID-19 pandemic has led to widespread changes in the way people work. Some of these changes represent the same kinds of work modifications or adjustments that have often been requested as workplace accommodations, and which may improve labour market and employment outcomes for people with disabilities. OBJECTIVE: The aim of this scoping review was to examine the literature on workplace accommodations in the pandemic and their impacts and implications for people with disabilities. METHODS: Following a search of six international databases, articles were selected by two reviewers, and data were abstracted in accordance with scoping review methodology. A thematic analysis was used to report the relevant findings. RESULTS: Thirty-seven articles met the inclusion criteria, and three main themes were identified: positive impacts of pandemic-related workplace accommodations on people with disabilities (e.g., improved accessibility, reduced stigma around workplace accommodations, rapid implementation of workplace accommodations, opportunities for advocacy); negative impacts (e.g., worsened physical and mental health, new accommodation needs); and action needed and recommendations (e.g., revisit legislation and policy on accommodations, ensure representation of people with disabilities). Overall, our review identified a mixed assessment of the impacts of pandemic-related accommodations on people with disabilities. However, there was a broader consensus regarding the importance of learning from the experiences of the pandemic to improve workplace accommodation policies in the future. CONCLUSIONS: The pandemic may present opportunities for improving workplace accommodation policies, but our review also highlights the need for more research examining how workplace changes due to the COVID-19 pandemic have impacted people with disabilities.
Safety behavior of agricultural workers around face mask-wearing during the COVID-19 pandemic
Authors: Hayati Abdollah
Published: October 2022

BACKGROUND: Agricultural labor-intensive activities have been threatened by COVID-19. Wearing a face mask has been introduced as one of the personal protective equipment (PPE) to reduce COVID-19 risk. OBJECTIVE: The present study aimed to investigate the safety behavior of urban green space workers around wearing a face mask in the time of COVID-19 before vaccination. METHODS: The personal and safety backgrounds of 61 male participants were collected using a designed questionnaire. The nonparametric correlation coefficients of Spearman and logistic regressions were used to investigate the relationships among variables. RESULTS: Above one-third of workers (37.7%) got COVID-19 in the past year. Although all of the participants were aware of wearing a face mask is a protocol against COVID-19, only about half of them (50.8%) completely wear face masks at work. Non-smoking participants were 5.5 times more likely to influence their personal preference on wearing the mask. CONCLUSION: Safety attitude may be a key variable in relation to the factors that influence the wearing face mask. The causes of face mask-wearing during a pandemic such as COVID-19 as well as safety attitudes may be behind the factors studied in this study. Although some significant linkages were found, they were not enough to conclude a comprehensive action program. This concern is still open to discovering factors that influence wearing face mask.
Impact of reimbursement program “Аffordable Medicines” on consumptiom of beta-blockers in Ukraine in 2017-2020
Authors: Gonchar Anton , Sholoiko Natalia
Published: October 2022

Abstract: the article presents the results of the study of impact of the reimbursement program “Affordable medicines” on consumption of beta-blockers in Ukraine, used for treatment of cardiovascular diseases. Analysis was conducted based on analytical data of Ukrainian pharmaceutical market research system “PharmXplorer” of the company “Proxima Research”, with current legislation taken into account. It was estimated, that in 2021, according to international non-proprietary name and 5th level of ATC classification - two non-selective beta-blockers: propanolol (ATC code С07АА05) and sotalol (С07АА07); six selective beta-blockers: metoprolol (С07АВ02), atenolol (С07АВ03), betaxolol (С07АВ05), bisoprolol (С07АВ07), esmolol (С07АВ09) and nebivolol (С07АВ12); and one beta-blocker from alpha and beta blocking agents group – carvedilol (C07GA02) are allowed for medical use in Ukraine. From the beginning, when reimbursement program “Affordable medicines” was implemented (April 1st, 2017), only 4 beta-blockers were included in the reimbursement list. Consumption patterns were analyzed in terms of defined daily dose, and it was estimated that bisoprolol was the leader among all beta-blockers in terms of consumption in period from 2016 to 2020. The findings show, that among beta-blockers, that were included in the reimbursement list, the major annual growth of consumption was detected for bisoprolol and carvedilol, although the growth of consumption of metoprolol and atenolol was noted only within the first year of functioning of the reimbursement program “Affordable medicines”, and beginning from 2018, the consumption of these two beta-blockers was declining annually. Among beta-blockers, that were not included in the reimbursement list, the increase in annual growth of consumption was spotted for nebivolol and sotalol. DDD/1000 inhabitants/day indicators were calculated for each beta-blocker. It was found, that throughout the years the biggest value of this indicator was for bisoprolol – 8,46 in 2016; 11,74 in 2017; 15,28 in 2018 ; 16,88 and 17,48 in 2019 and in 2020 respectfully. The growth of this indicator can give evidence about positive effect of the reimbursement program “Affordable medicines” on consumption of bisoprolol and its affordability for population in Ukraine in 2017-2020.
Nutritional support for patients under the ERAS protocols during TAPP in wartime and the COVID-19 pandemic
Authors: Prykhodko Yevhenii , Ioffe Oleksandr , Stetsenko Oleksandr , Kryvopustov Mykola
Published: October 2022

the problem of rapid recovery, reduction after surgical stress is becoming more relevant every day, so we propose to consider the impact of sip feeding nutritional support under the ERAS protocols (Sánchez C, A., & Papapietro V, K. (2017)) in patients with inguinal hernias. This study used the method of interviewing 41 patients who were treated at the Department of General Surgery №2 NMU named after O.O. Bogomolets, a planned TAPP operation was performed using ERAS and sip feeding nutritional support (group 1) and comparison of the obtained data
Підковоподібна нирка, комплексне радіонуклідне дослідження
Authors: Tertychna Daryna , Romanenko Anna , Tkachenko Mikhail
Published: October 2022

в статі розглянуті питання встановлення функціональної здатності підковоподібної нирки як загалом, так і по її номінальних частках, за допомогою динамічної реносцинтиграфії. Такі дослідження є необхідними для дітей будь якого віку з виявленими аномаліями розвитку сечовивідної системи для одночасного дослідження анатомо-топографічного стану і функціональної здатності аномально розвинутої нирки.
End-use energy indicator approach to improve energy performance at the National University of Colombia Bogotá, under the parameters of the ISO 50001 standard
Authors: Medina Wintaco Pierre Anthony , Tellez Sandra Milena , Prias Omar Fredy
Published: October 2022

The university belongs to the services sector, which is why it cannot implement traditional industry indicators such as energy consumption per unit produced. For this reason, we propose indicators for the final use of energy. The indicators were developed through an energy review process of the information in the database of advanced energy meters with the support of the Specialist in Geographic Information Systems of the Environmental Management Office (EMO). Additionally, we considered several existing reports that characterized the final use of energy for some buildings and essential data for defining the percentages each final use will have within the conglomerate of loads registered. Continuity was also given to this process by collecting face-to-face information with the support of each building’s environmental manager. This article shows the behavior of two buildings of the National University Bogotá, the Uriel Gutiérrez building and the Roberto Franco Station, to propose an indicator of final energy use. This approach enabled determining in which end-use the load has the highest consumption, taking into account that this may contribute to the management system energy of the university. This article uses the guidelines implemented in the ISO 50001 standard.
Suppression of the Testis-Specific Transcription of the ZBTB32 and ZNF473 Genes in Germ Cell Tumors
Authors: Bulanenkova Svetlana S. , Filyukova Olga B. , Snezhkov Eugene V. , Akopov Sergey B. , Nikolaev Lev G.
Published: October 2022

The family of genes containing C2H2 zinc finger domains, which has more than 700 members, is one of the largest in the genome. Of particular interest are C2H2 genes with potential tissue-specific transcription, which determine the functional properties of individual cell types, including those associated with pathological processes. The aim of this work was to identify C2H2 family genes with tissue-specific transcription and analyze changes in their activity during tumor progression. To search for these genes, we used four databases containing data on gene transcription in human tissues obtained by RNA-Seq analysis. The analysis showed that, although the major part of the C2H2 family genes is transcribed in virtually all tissues, a group of genes has tissue-specific transcription, with most of the transcripts being found in the testis. After having compared all four databases, we identified nine such genes. The testis-specific transcription was confirmed for two of them, namely ZBTB32 and ZNF473, using quantitative PCR of cDNA samples from different organs. A decrease in ZBTB32 and ZNF473 transcription levels was demonstrated in germ cell tumors. The studied genes can serve as candidate markers in germ cell tumors.
Human Artificial Chromosomes and Their Transfer to Target Cells
Authors: Ponomartsev Sergey V. , Sinenko Sergey A. , Tomilin Alexey N.
Published: October 2022

Human artificial chromosomes (HACs) have been developed as genetic vectors with the capacity to carry large transgenic constructs or entire gene loci. HACs represent either truncated native chromosomes or de novo synthesized genetic constructs. The important features of HACs are their ultra-high capacity and ability to self-maintain as independent genetic elements, without integrating into host chromosomes. In this review, we discuss the development and construction methods, structural and functional features, as well as the areas of application of the main HAC types. Also, we address one of the most technically challenging and time-consuming steps in this technology – the transfer of HACs from donor to recipient cells.
Visualization of G-Quadruplexes, i-Motifs and Their Associates
Authors: Dubrovin Evgeniy V. , Barinov Nikolay A. , Klinov Dmitry V.
Published: October 2022

The non-canonical structures formed by G- or C-rich DNA regions, such as quadruplexes and i-motifs, as well as their associates, have recently been attracting increasing attention both because of the arguments in favor of their existence in vivo and their potential application in nanobiotechnology. When studying the structure and properties of non-canonical forms of DNA, as well as when controlling the artificially created architectures based on them, visualization plays an important role. This review analyzes the methods used to visualize quadruplexes, i-motifs, and their associates with high spatial resolution: fluorescence microscopy, transmission electron microscopy (TEM), and atomic force microscopy (AFM). The key approaches to preparing specimens for the visualization of this type of structures are presented. Examples of visualization of non-canonical DNA structures having various morphologies, such as G-wires, G-loops, as well as individual quadruplexes, i-motifs and their associates, are considered. The potential for using AFM for visualizing non-canonical DNA structures is demonstrated.
Reporter Transgenes for Monitoring the Antitumor Efficacy of Recombinant Oncolytic Viruses
Authors: Semenova Anastasiya V. , Sivolobova Galina F. , Grazhdantseva Antonina A. , Agafonov Alexander P. , Kochneva Galina V.
Published: October 2022

Accurate measurement of tumor size and margins is crucial for successful oncotherapy. In the last decade, non-invasive imaging modalities, including optical imaging using non-radioactive substrates, deep-tissue imaging with radioactive substrates, and magnetic resonance imaging have been developed. Reporter genes play the most important role among visualization tools; their expression in tumors and metastases makes it possible to track changes in the tumor growth and gauge therapy effectiveness. Oncolytic viruses are often chosen as a vector for delivering reporter genes into tumor cells, since oncolytic viruses are tumor-specific, meaning that they infect and lyse tumor cells without damaging normal cells. The choice of reporter transgenes for genetic modification of oncolytic viruses depends on the study objectives and imaging methods used. Optical imaging techniques are suitable for in vitro studies and small animal models, while deep-tissue imaging techniques are used to evaluate virotherapy in large animals and humans. For optical imaging, transgenes of fluorescent proteins, luciferases, and tyrosinases are used; for deep-tissue imaging, the most promising transgene is the sodium/iodide symporter (NIS), which ensures an accumulation of radioactive isotopes in virus-infected tumor cells. Currently, NIS is the only reporter transgene that has been shown to be effective in monitoring tumor virotherapy not only in preclinical but also in clinical studies.
MicroRNA Expression Profile Changes in the Leukocytes of Parkinson’s Disease Patients
Authors: Ardashirova Natalia S. , Abramycheva Natalia Yu. , Fedotova Ekaterina Yu. , Illarioshkin Sergey N.
Published: October 2022

Parkinsons disease (PD) is one of the most common movement disorders. It is primarily diagnosed clinically. A correct diagnosis of PD in its early stages is important for the development of a pathogenic treatment, which necessitates a search for potential biomarkers of the disease. We evaluated the diagnostic value of several microRNAs and their relationship with the clinical characteristics of PD. The study included 70 PD patients and 40 healthy volunteers. We analyzed the expression of 15 microRNAs in blood leukocytes, which were selected based on literature data and modern concepts of molecular PD pathogenesis. All patients were evaluated using the Hoehn and Yahr scale, UPDRS, NMSQ, and PDQ-39. The data analysis revealed a statistically significant increase in the expression of miR-7-5p, miR-29c-3p, and miR-185-5p and a statistically significant decrease in the expression of miR-29a-3p and miR-30c-1-5p in leukocytes in PD. However, the altered microRNA profile was shown to have a moderate diagnostic value for PD diagnosis. MicroRNA expression changes were associated with the motor and non-motor phenotypic features of PD and administration of anti-Parkinsons drugs. Also, a relationship between some of the microRNAs studied and the duration and severity of PD was found, which may potentially be used to monitor disease progression.