bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of risk factors for the development of bacteremia and complications in patients with brucellosis: Is it possible to predict the clinical course?
Authors: Kuruoglu Tuba , Sensoy Levent , Atilla Aynur , Temocin Fatih , Gur Demet , Tanyel Esra
Published: October 2023

Introduction: Brucellosis is often confused with other diseases or accompanies the conditions it imitates. It causes treatment delays, failure, relapse, and complications. This study aimed to investigate bacteremia and complication predictors in Brucellosis patients. Early detection may help reduce relapse rates, length of hospital stay, and surgical intervention rates by providing appropriate treatment.
Methodology: We examined 220 adult patients diagnosed with Brucellosis in our tertiary care hospital in the Black Sea Region between January 01, 2010, and January 01, 2022. Patients with and without bacteremia and complications were compared regarding demographic characteristics, clinical features, and laboratory parameters.
Results: The mean age was 46.4 ± 15.8 years (18-96 years), and 61% were male. Low back pain and absence of muscle pain were independent risk factors for predicting bacteremia (p = 0.049, p = 0.043, respectively). Weakness /fatigue, weight loss, and 1/320 Standard Tube Agglutination Test (STAT) or Brucella Coombs Gel Test (BCGT) titers were independent risk factors that reduced the risk of complications; in contrast, low back pain and splenomegaly were independent risk factors for development of complications. (p = 0.025, p = 0.007, p = 0.008, p = 0.003, p = 0.021 respectively). Thrombocytopenia was related to complications. When the platelet cut-off value was taken as 160,000/µL in predicting complications, the sensitivity was 31.30%, and the specificity was 97.73% (p = 0.011).
Conclusions: The risk of clinical progression and complications could be predicted with symptoms and signs such as myalgia, low back pain, weakness/fatigue, weight loss, splenomegaly, and easily accessible laboratory parameters such as serum STAT/BCGT titer and platelet level.
The in vitro equivalence study of polymorph-modified glimepiride tablets compared to Amaryl®
Authors: Darusman Fitrianti , Rusdiana Taofik , Sopyan Iyan , Aryani Ratih , Cahya Eka Darma Gita
Published: October 2023

Glimepiride (GMP) is an oral antidiabetic drug classified as BCS class II, demonstrating extremely limited solubility, with a solubility level below 0.00384 mg/mL. Some generic drug manufacturers producing GMP (copy product) tablets encountered bioavailability issues due to poor dissolution, which did not meet the requirements. Therefore, measures were taken to enhance solubility through the modification of polymorphs. It is known that GMP exists in two polymorphic forms, namely Form I and an alternative Form II, which exhibits higher solubility in water. This study aims to produce and characterize the polymorph-modified GMP compared to non-modified GMP, develop an optimal formulation for polymorph-modified GMP tablets that adhere to pharmaceutical requirements as a representative copy drug model, and determine its similarity factor to Amaryl® as the innovator. The research methodology involved initiating the study by examining the polymorph transformation of GMP through the utilization of techniques such as neat grinding, solvent drop grinding, and solvent evaporation. The resulting samples were characterized using DSC, PXRD, and SEM analysis. The performance assessment encompassed the evaluation of flow properties, compressibility index, solubility, and dissolution rate compared to the non-modified GMP. Based on the characterization results, the best polymorph-modified GMP sample was used to produce a tablet formulation containing 4 mg of GMP using the direct compression method as a copy tablet model. In vitro equivalence testing was performed using a comparative dissolution test on the polymorph-modified GMP tablet compared to its innovator, Amaryl® 4 mg, in three different dissolution media, followed by determining the equivalence status using the similarity factor (f2) calculation. Based on the screening results of polymorph transformation, it was determined that the polymorph-modified GMP, using all three techniques, did not undergo a transition from Form I to Form II. Instead, it underwent amorphization, primarily observed in the solvent evaporation technique. Tablets containing polymorph-modified GMP using the solvent evaporation technique were able to enhance the in vitro dissolution rate profile compared to non-modified GMP tablets. The f2 values for the comparative in vitro dissolution test in acetate buffer pH 4.5 and phosphate buffer pH 6.8 were 60.15 ± 0.27 and 88 ± 0.35, respectively within acceptance criteria of 50–100. However, in KCl/HCl buffer pH 1.2, the f2 value was 45.15 ± 0.23. It was concluded that the polymorph-modified GMP tablet was not similar to its innovator, Amaryl®.
Pologne, des élections qui inquiètent
Authors: Potel Jean-Yves
Published: October 2023

Les rapports de force sont toujours incertains à la veille des élections polonaises du 15 octobre 2023.
Artificial Intelligence-Based Chatbot to Support Public Health Services in Indonesia
Authors: Setiawan Rudi , Iskandar Rossi , Madjid Nadilla , Kusumawardani Ridwan
Published: October 2023

The aim of this study is to build an artificial intelligence chatbot application to support public health services. The chatbot acts as an information service that can replace the role of humans. The analysis of functional needs was obtained from information submitted by one of the heads of public health centers in Indonesia. This study uses the Scrum method with pregame stages to produce a plan consisting of functional and non-functional requirements analysis and conceptual design of the chatbot, which will be developed using Unified Modeling Language (UML) diagrams. The process of finding answers uses the matching graph master technique, which is a backtrack matching that utilizes a depth-first search strategy. There are 6 topics of chatbot services, including service schedules, health information, registration, diseases, drugs, and early care services for chatbot users. Tests conducted on these 6 topics showed an average correct answer ratio of 93.1% out of a total of 251 questions. The result of the usability measurement on the chatbot application that has been built obtained a system usability scale value of 80.1, indicating that the developed chatbots are acceptable for use.
Development and Creation of Ancient Sandstone Carvings Using 3D Software Tools and Mobile/Tablet Devices
Authors: Sookkaew Jirawat , Kaenmueang Wisoot , Chaikaew Nakarin
Published: October 2023

In the area of Phayao Province that used to be part of the ancient Lanna Kingdom, there are unique works of art that can be found until today, which are sandstone carvings caused by religious beliefs resulting in works such as Buddha statues. These are art related to religion. Nowadays, these works of art have started to fade away and receive less and less attention from people. The creation of art objects in this research therefore uses the interpretation of the creative objects in line with people’s lifestyles by selecting the lotus, which is a plant related to rivers, and is important in religion. In the lotus, which is interconnected and aligned with Buddhism, and in harmony with a way of life that aligns with the river, creative works are found in various forms, connecting people in Buddhism, including sandstone carving. In this creation, digital technology tools and methods are used to collect data to create a 3D work piece. Photogrammetry is used to record detailed proportions and information and customization of 3D work pieces. In these steps, mobile phone-type tools are used to collect image data to create the 3D work or an application is used to customize 3D work pieces from a tablet device to create prototypes of sandstone sculptures from the artisans that remain today. This can be seen in creating, maintaining, and recording digital data, creation, and the integration of knowledge. This demonstrates that today’s tools and portable devices can help create more creative pieces of work and preserve art and culture.
Low-cost Wireless Lamp Socket and Power Plug for Smart Homes and Its Comparison with Available Commercial Competitors
Authors: Fuada Syifaul , Hendriyana  , Subashri Duttagupta  , Nuur Wachid Abdul Majid
Published: October 2023

Smart home manufacturers widely produce Wireless Lamp Socket and Power Plug devices, which offer various features ranging from basic on/off control to more complex functionalities such as monitoring energy consumption, power losses, and harmonics. However, these devices tend to be expensive, as indicated by market surveys. To address this issue, the current study aimed to develop low-cost wireless control nodes for smart homes that operate using relays. The two nodes consisted of lamp socket and power plug built with lowcost electronic components, including a Wi-Fi built-in Microcontroller ESP8266 (Wemos D1 mini model) as the backbone to create ESP-Mesh wireless network and to provide control ports for high/low logic, a relay module, an AC-to-DC converter module, and terminals (E27 screw for lamp socket node and C-type plug for the power plug node). This paper primarily focuses on the hardware aspects. In order to evaluate the effectiveness of the nodes, the following tests are conducted: (1) product demonstration to assess the product functions, (2) power measurement in idle and active conditions, (3) ESP-Mesh connection testing, and (4) RSSI measurement. Functional testing is done using a smartphone with the UPISmartHome version 2.0 Android application, which successfully controlled the nodes wirelessly. In idle conditions, power plug and lamp socket nodes consume 426.36 mWatt and 418.275 mWatt of power, respectively. Further, in active conditions, power plug and lamp socket nodes consume 435.704 mWatt and 440.583 mWatt of power, respectively. RSSI testing results show that both nodes can be controlled within an optimal range of 60 meters (with reference to RSSI below –85 dBm) without the Internet, utilizing the ESP-Mesh feature of ESP8266. This range is deemed reasonable for smart homes of 21, 36, or 45 square meters. Both nodes could be controlled under the ESP-Mesh network that gets build. We also present the comparison with other products of competitors in this paper.
Optimizing Clustering Approaches in Cloud Environments
Authors: Al-Ghuwairi Abdel-Rahman , Al-Fraihat Dimah , Sharrab Yousef , Kreishan Yazeed , Alsarhan Ayoub , Idhaim Hasan , Qahmash Ayman
Published: October 2023

This study focuses on the challenge of developing abstract models to differentiate various cloud resources. It explores the advancements in cloud products that offer specialized services to meet specific external needs. The study proposes a new approach to request processing in clusters, improving downtime, load distribution, and overall performance. A comparison of three clustering approaches is conducted: local single cluster, local multiple clusters, and multiple cloud clusters. Performance, scalability, fault tolerance, resource allocation, availability, and cost-effectiveness are evaluated through experiments with 50 requests. All three approaches achieve a 100% success rate, but processing times vary. The local single cluster has the longest duration, while the local multiple clusters and multiple cloud clusters perform better and offer faster processing, scalability, fault tolerance, and availability. From a cost perspective, the local single cluster and local multiple clusters incur capital and operational expenses, while the multiple cloud clusters follow a pay-as-you-go model. Overall, the local multiple clusters and multiple cloud clusters outperform the local single cluster in terms of performance, scalability, fault tolerance, resource allocation, availability, and cost-effectiveness. These findings provide valuable insights for selecting appropriate clustering strategies in cloud environments.
Signature Verification Based on Dex CRC and Blake2 Algorithm to Prevent Reverse Engineering Attack in Android Application
Authors: Ilham  , Muhammad Niswar  , Ady Wahyudi Paundu
Published: October 2023

The rapid growth of Android applications has led to more cybercrime cases, specifically Reverse Engineering attacks, on Android apps. One of the most common cases of reverse engineering is application repackaging, where the application is downloaded via the Play Store or the official website and then repackaged with various additions or changes. One of the ways to avoid Application Repackaging attacks is to check the signature of an application. However, hackers can manipulate the application by adding a hook, i.e., replacing the original function for getting signatures with a new modified function in the application. In this research, the development of a verification method for Android applications is carried out by utilizing Dex CRC and the Blake2 algorithm, which will be written in C using the Java Native Interface (JNI). The results of this study indicate that the verification method using Dex CRC and the Blake2 algorithm can effectively protect Android applications from Application Repackaging attacks without burdening application performance.
Data Visualization of Big Data for Predictive and Descriptive Analytics for Stroke, COVID-19, and Diabetes
Authors: Segall Richard S. , Takashashi Soichiro
Published: October 2023

Visualization of big data is crucial for meaningful interpretations and especially for healthcare. Brief discussions are made for big data, background for healthcare, and recent work in big data analytics for healthcare. This research pertains to different levels of big data: 5,110 vs. 101,766 vs. 320,200 vs. 1 million data values. Data visualizations and predictive analytics are presented of big data for selected diseases of stroke with 5,110 data values, diabetes with 101,766 data values, and two COVID-19 studies: one with 320,200 data values and another with 1 million data values. Data visualizations are generated for these diseases with big data using Tableau. For stroke patients, an investigation was performed to determine how different living environments affect relationship between strokes. The data visualizations for diabetes showed impact of insulin use yielded reduced hospital stays. Data visualizations for COVID-19 provided temporal trends in confirmed cases, mortality, and recovery rates for 2020-2023. Conclusions and future directions of research are presented.
Digital Gaming for Cross-Cultural Learning
Authors: Titus Simone , Ng'ambi Dick
Published: October 2023

Although game-based learning has gained significant attention in higher education globally, it is difficult to harness its engagement and interactions to improve student success. This paper argues that the use of digital games has the potential to interrupt social practices and increase engagement and interaction, thereby fostering meaningful learning. Using a mixed-method design, a digital game was used in a sport studies programme, involving 106 participants, over a two-year period. Data were collected through surveys, focus group discussions, and reflective blog posts. Structuration theory is considered as the theoretical lens, as it purports that recursive social activities of humans are continually recreated by human agents. The paper concludes that when participants engaged in a cross-cultural game-based learning environment, the social practices acquired through their academic career were interrupted, reshaped, and reproduced into new practices. A social constructivist game-based learning model to foster interaction within multi-cultural higher education classrooms is offered.
Espaço urbano: análise sobre o gerenciamento dos resíduos sólidos produzidos pelos moradores do bairro Nossa Senhora de Fátima-Tefé/AM
Authors: Silva Luiz Carlos Souza da , Rodrigues Eubia Andréa
Published: October 2023

Esse artigo é uma reflexão sobre a produção dos resíduos sólidos no espaço urbano de Tefé-AM, especificamente no bairro Nossa Senhora de Fátima, através de uma abordagem ambiental, considerando que foi diagnosticada no bairro uma grande produção de resíduos descartados nas ruas e em lugares impróprios pelos moradores, proporcionando relevantes impactos socioambientais. Nesse sentido, foi pensada uma ação que pudesse contribuir para minimizar tais impactos. Elaboramos um projeto com o objetivo de identificar os impactos socioambientais e propor às pessoas o estímulo de participar na construção da cidadania e compreender os deveres que todos têm com uma melhor qualidade de vida. O método utilizado foi o analítico, dentro de uma abordagem empírica, onde foi possível uma conversa informal com os moradores, além de entrevistas com trinta deles para que pudéssemos construir a história do bairro e compreender as angústias e anseios dos mesmos. Os resíduos foram encontrados aos arredores das casas, nos terrenos baldios, às margens do Igarapé Xidarini e debaixo das pontes, sendo esse o maior foco de resíduos sólidos encontrados, tanto no período de cheia como na seca. Esse estudo tem o propósito de sensibilizar os moradores do bairro Nossa Senhora de Fátima a buscarem valores que conduzam para uma convivência harmoniosa com o meio e com as demais espécies que habitam o planeta, auxiliando-os a analisar criticamente os princípios que têm levado à destruição inconsequente dos recursos naturais e de várias espécies. É fundamental que cada um dos moradores desenvolva as suas potencialidades e adote posturas pessoais e comportamentos sociais construtivos, colaborando para a construção de uma sociedade justa e de um ambiente saudável.
Boerhaave’s syndrome in a case of acute exacerbation of chronic obstructive pulmonary disease managed with non-invasive ventilation: a case report
Authors: Bini Roberto , Frassini Simone , Fontana Diego , Naretto Giuseppe , Chiara Osvaldo
Published: October 2023

Barotraumatic esophageal rupture (Boerhaave’s syndrome) is a rare and life-threatening disease, described as a Non-Invasive Ventilation (NIV) complication in a very small series. We report the case of a 72-year-old man admitted to the Emergency Department (ED) for severe dyspnea in a Chronic Obstructive Pulmonary Disease (COPD) stage Gold III. After NIV treatment, the patient suffered esophageal perforation with mediastinal and pleural contamination: emergency surgical treatment was successful for the esophageal repair, but the patient developed a fatal septic shock 12 days after surgery. Among NIV complications, few cases concern esophagogastric perforation: our case report describes an uncommon clinical situation treated with a successful damage control surgery approach.
Is T3 appendiceal goblet cell adenocarcinoma still an oncological riddle for acute care surgeons? A case report
Authors: Bergna Alessandro , Salvetti Francesco , Carando Simona , Monti Marco , Segalini Edoardo
Published: October 2023

Appendectomy for acute appendicitis is one of the most commonly performed surgical procedures nowadays. Here we present the case of a 48-year-old man who was admitted to our emergency department with abdominal pain suggestive of acute appendicitis. Then, the patient underwent a laparoscopic appendectomy, and the histological examination of the surgical specimen revealed an unexpected occult neoplasm: goblet cell adenocarcinoma (GCA). After a multidisciplinary evaluation, a right colectomy was performed with good oncological and clinical outcomes at the 1-year follow-up evaluation. To date, either nonoperative strategies or surgical radicalization treatment have been proposed for this condition. Therefore, the choice of the proper therapeutic algorithm is still a challenge for surgeons. This case report is an addition to the existing literature to hold surgeons' attention when managing such cases: multidisciplinary evaluation and patient-targeted therapies are the key steps to achieving good oncological and surgical outcomes.
Overexpression of hsa_circ_0001861 inhibits pulmonary fibrosis through targeting miR-296-5p/BCL-2 binding component 3 axis
Authors: Wu Tao , Wu Shikui , Jiao Hailu , Feng Jun , Zeng Xiang
Published: October 2023

Pulmonary fibrosis is a progressive lung disorder. Evidence has shown that hsa_circular (circ)RNA_0001861 is dysregulated in pulmonary fibrosis. However, the detailed function of hsa_circRNA_0001861 in pulmonary fibrosis remains unexplored. To investigate the function of hsa_circRNA_0001861 in pulmonary fibrosis, human pulmonary fibroblasts in vitro were used, and cell counting kit-8 (CCK-8) and 5-ethynyl-2’-deoxyuridine (EdU) staining were performed to assess cell viability and proliferation, respectively. Western blot analysis and reverse transcription-quantitative PCR (RT-qPCR) were used to evaluate protein and mRNA levels. Meanwhile, the relationship among hsa_circRNA_0001861, miR-296-5p and BCL-2 binding component 3 (BBC3) was investigated by RNA pull-down assays. Furthermore, an in vivo model of lung fibrosis was constructed to assess the function of hsa_circRNA_0001861 in lung fibrosis. The data revealed that TGF‑β1 significantly increased the proliferation of pulmonary fibroblasts, while this phenomenon was markedly abolished by hsa_circRNA_0001861 overexpression. hsa_circRNA_0001861 overexpression markedly inhibited TGF‑β1‑induced fibrosis in pulmonary fibroblasts through the mediation of α-smooth muscle actin, E-cadherin, collagen III and fibronectin 1. Meanwhile, hsa_circRNA_0001861 could bind with miR-296-5p, and BBC3 was identified to be the downstream mRNA of miR-296-5p. In addition, the upregulation of hsa_circRNA_0001861 clearly reversed TGF‑β1‑induced fibrosis and proliferation in pulmonary fibroblasts through the upregulation of BBC3. Furthermore, hsa_circRNA_0001861 upregulation markedly alleviated pulmonary fibrosis in vivo. Hsa_circRNA_0001861 upregulation attenuated pulmonary fibrosis by modulating the miR-296-5p/BBC3 axis. Hence, the present study may provide some insights for the discovery of new methods against pulmonary fibrosis.
Subcutaneous Implantable Cardioverter-defibrillator Lead Repositioning Due to Device Sensing Impairment in a Patient with Scoliosis
Authors: Nourani Mahsa , Mahdinejadshani Mahdiyeh , Shirazi Samira , Pourmomeni Seyed Ali , Kamali Farzad
Published: October 2023

Despite many well-documented benefits of the transvenous implantable cardioverter-defibrillator in appropriate patients, there is a strong preference today for subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation due to the significant late complications associated with intravenous leads, especially in young patients. We report on an 18-year-old woman with S-ICD due to hypertrophic cardiomyopathy who had idiopathic dextroscoliosis. In the follow-up analysis, we observed a disturbance in the normal detection of QRS complexes by the device, which significantly reduced when the patient changed the position from standing to supine and when the brace was closed. According to the absence of lead displacement in the chest radiograph, S-ICD sense impairment was suggested due to skeletal deformity. Due to not solving this problem with device reprogramming, we had to reposition of the S-ICD lead in our patient.
Safety and Efficacy of Patent Foramen Ovale Device Closure: Evaluation of Outcomes in a Tertiary Referral Center
Authors: Favaedi Maryam , Danesh-Moghadam Maryam , Khajali Zahra , Firouzi Ata , Parsaee Mozhgan , Saedi Sedigheh
Published: October 2023

Aim and Objectives:

Recent randomized controlled trials have demonstrated the benefit of patent foramen ovale (PFO) device closure over medical therapy alone for secondary prevention of cryptogenic stroke in carefully selected patients. In the current study, we sought to investigate the outcomes and complications of PFO device closure in our referral tertiary cardiovascular center.

Materials and Methods:

In this retrospective study, 155 adult patients who underwent PFO device closure between 2006 and 2021 were included. Patient characteristics, recurrent neurologic events, and procedure-related complications were evaluated.

Results:

The follow-up period was 2.3 ± 1.2 years. The average age of the participants was 41.3 ± 10 years, and 59.4% were male. Six patients (3.9%) suffered recurrent cerebrovascular events in the follow-up. No procedure-related complications were reported in our study population. Two patients (1.3%) with recurrent stroke had developed newly diagnosed atrial fibrillation (AF).

Conclusion:

PFO device closure is a safe and effective method for the prevention of recurrent ischemic stroke in patients with no other detectable etiology. Patients, particularly those with cardiovascular risk factors, should be meticulously investigated for the asymptomatic episodes of AF as the contributing factor with prolonged Holter monitoring or use of loop recorders.
Vertebral osteomyelitis associated with Enterococcus faecalis in Broiler Breeders in Chile
Authors: Cádiz Leandro , Guzmán Miguel , Navarrete Fernando , Torres Paulina , Hidalgo Hector
Published: October 2023

Vertebral osteomyelitis is a re-emerging disease characterized by inflammation and necrosis of the thoracic vertebral body, caused by Enterococcus cecorum.  Here, we report the first case of vertebral osteomyelitis caused by Enterococcus faecalis in Broiler Breeders, in Chile, which also causes infections in humans and is resistant to multiple antimicrobials, representing a risk to public health.
Solving viscoelastic problems with a Laplace transform approach supplanted by ARX models, suggesting a way to upgrade Finite Element or spectral codes
Authors: André Stéphane , Noûs Camille
Published: October 2023

Finite Element codes used for solving the mechanical equilibrium equations in transient problems associated to (time-dependent) viscoelastic media generally relies on time-discretized versions of the selected constitutive law. Recent concerns about the use of non-integer differential equations to describe viscoelasticity or well-founded ideas based upon the use of a behavior's law directly derived from Dynamic Mechanical Analysis (DMA) experiments in frequency domain, could make the Laplace domain approach particularly attractive if embedded in a time discretized scheme. Based upon the inversion of Laplace transforms, this paper shows that this aim is not only possible but also gives rise to a simple algorithm having good performances in terms of computation times and precision. Such an approach, which fully relies on the Laplace-defined Behavioral Transfer Function (LTBF) can be promoted if it uses AutoRegressive with eXogeneous input parametric models perfectly substitutable to the real LTBF. They avoid the hitherto prohibitive pitfall of having to store all past data in the computer's memory while maintaining an equal computation precision.
Collaborative Paper Writing as a Tool to Advance Language Competence
Authors: Makena Bulelwa
Published: October 2023

As an effective tool to advance language competence, writing papers collaboratively has the characteristic of improving author language skills, providing authors with opportunities to practice language skills in meaningful contexts. As authors collaborate to yield a paper, they get exposure to grammar genres, structures, and expressions. Concurrently, during the process, language is applied to communicate ideas effectively. This paper aims to investigate whether collaboration is really a beneficial aspect for authors. This qualitative investigation was embedded in case study design to uncover truths experienced in real-life situations. To collect data, semi-structured interviews were administered to five university scholars chosen from a population of authors reported to have successfully written publishable papers. It emerged as major findings that individual comprehension can be improved when authors collaborate on paper writing, and, as authors receive written feedback from each other, language competence advances. Although previous publications on writing collaboratively exist, research is silent on improved language competence acquired through this practice. It is concluded that individual comprehension can be improved by collaborative paper writing as the process provides opportunities for authors to justify and discuss their ideas. As they work collaboratively, authors deepen their understanding of the material and enhance their language skills.
Konut Kültürü ve İzmir Yüksek Teknoloji Enstitüsü Lojmanları Uygulaması
Authors: BENLİ Ayşen Cevriye
Published: October 2023

İnsanların göçebe yerleşim biçimini benimsediklerinden ve çadırdan yerleşik düzene yuva olarak geçtikten bu yana yüzyıllar geçti. Tarihte birçok konut türü insanlığın barınma gereksinimini karşıladı. Günümüzdeyse artık çok katlı yapılarda barınmak toplu konut kavramı içinde yer alırken, eskisi gibi bir veya iki katlı bahçeli evleri yuva olarak benimsemek, olanaklar elverdikçe daha tercih edilir oldu. Bu, aslında bir yerde insanın doğaya ve özüne dönmek istemesinin en doğal sonucudur. Hiçbir yüzyılda aslında yapay özellikler taşıyan yenilikler ve toplumsal beğeniler uzun süre yaşayamamıştır. Değişen tasarımlardan, yenilenen yaşamdan söz edilmektedir. Gerçekten yenilenen bir yaşamdan çok aslımıza ve özümüze dönüşten söz edilebilir. Bütün bunlar doğanın, açık havanın ve doğal malzemenin insan yaşamı için ne kadar önemli olduğunu anımsatıyor çünkü yakın zamanda, salgını yaratan bir virüs, açık havada yaşamı ve iç mekânı nasıl olup da belirleyeceğini gösterdi. Günümüzün endüstrileşmiş ve yoğunlaşmış yaşamının ne kadar sakıncalar doğurduğu açıkça ortaya çıktı. Doğaya dönüşün önemini insanlığa anımsattı. Bir devlet üniversitesi olan ve kampüsü İzmir’in Urla ilçesinin Gülbahçe koyunun yakınında yer alan İzmir Yüksek Teknoloji Enstitüsü Lojmanları için yapılan konutlar, iki kata izin veren imar durumuna ve doğaya uyum göstererek tek katlı veya iki katlı bahçeli ikiz konutlar olarak tasarlandı. Yapım aşaması için kısıtlı bütçe ayrılmış olması tasarımı sınırlamış olmakla birlikte konutların geniş zeytinlikler içinde deniz manzaralı doğal bir ortamda bulunan yerleşkede yapılması, işin başında en olumlu yönüydü. Bu çalışmada, İYTE Lojmanları özelinde yapılarla ilgili tasarım ve yapım süreçlerine bakıldığı gibi konut tasarımıyla çevrenin biçimsel ilişkisine, konut, doğa, biçim ilişkisine ve konut kültürü ve kullanıcı ilişkisine bakılarak gelecek uygulamalara katkıda bulunulması açısından değerlendirildi.
An observational analysis of blood and urine testosterone in diagnosis of polycystic ovarian syndrome
Authors: Fernanda M.A. Hanny Ferry , Ashon Sa’adi  , Sudjarwo
Published: October 2023

Background: An important diagnostic tool for the diagnosis of Polycystic ovarian syndrome (PCOS) in women is elevated blood testosterone levels. The presence of testosterone in the urine is very likely to support the PCOS diagnosis; however, more investigation is required to determine whether blood testosterone levels are associated with PCOS.
Objective: A total of 30 PCOS-positive women participated in this observational study using a diagnostic test approach.
Method: The ELISA technique was used to measure the amounts of testosterone in the woman's urine and serum.
Result: The levels of testosterone in the urine of 30 PCOS women were lower than those in the serum, with values of 2.688 nmol/L and 8.067 nmol/L, respectively. The Spearman correlation test findings revealed a value of 0.39 at a significance level of 0.05, with a cut-off value of 2.6010 nmol/L at sensitivity and specificity of 0.625 and 0.571, showing the importance of urine testosterone levels in detecting hyperandrogenic PCOS patients.
Conclusion: In women with PCOS, serum and urine testosterone levels are correlated.
INTRODUCTION TO BRITISH HISTORY AND CULTURE https://doi.
Authors: Ignjatović Sanja
Published: October 2023

Introduction to British History and Culture sums up modest, almost a decade long, experience in teaching the course called British Studies at the Faculty of Philosophy in Niš, first as a Teaching Assistant to Professor Milena Kaličanin, using the textbook written by Professor Vesna Lopičić1. This was the same coursebook I used as a student taking this course at the Department of English, and then as Assistant Professor teaching it for the first time. Inspired by stimulating discussions with students, and contemplations on the relevance of the course to the (Gen Z) students whose knowledge of things British is often limited to interpretations offered by the popular culture, this textbook aims to provide an overview of history and shed light on the British culture as produced by complex historical circumstances. I humbly hope the textbook will complement the legacy established by Professor Lopičić in designing the course, the materials – two additional Anthologies, and the teaching style.
Ações pedagógicas no universo simbólico de crianças de 4 a 6 anos em Eirunepé, Amazonas
Authors: Ribeiro Francisco Irapuan , Silva Antônio Arlen Alves da , Souza Brendow Marques Siqueira de , Araújo Eduardo Ribeiro de
Published: October 2023

O objetivo foi revelar possíveis oportunidades para o desenvolvimento de atividades lúdicas de forma pedagógica, destinadas a crianças de 4 a 6 anos em Eirunepé, AM. Empregou-se uma abordagem de pesquisa-ação, alicerçada em fundamentos teóricos que abrangem planejamento, implementação e avaliação. Contudo, esta abordagem permanece aberta a ajustes no processo e a possíveis adaptações em suas reproduções. Os resultados primordiais indicam que as crianças são capazes de relacionar as práticas às suas vivências anteriores, envolvendo-se ativamente nas atividades. Entretanto, é essencial implementar adaptações, tanto em termos de materiais quanto de abordagens metodológicas. Isso possibilitará a rápida reestruturação de estratégias diante de possíveis desinteresses por parte das crianças, alinhando-se a experiências que as mantenham engajadas no processo de aprendizagem. A conclusão é que, mesmo possuindo um planejamento preestabelecido, é imperativo abordar cada ação de maneira pedagógica, e com as devidas adaptações que devem estar alinhadas à faixa etária das crianças.
Editorial
Authors: Salcedo Beltrán Carmen
Published: October 2023

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The Relationship Between Exclusive Breastfeeding And Complementary Feeding With The Incidence Of Stunting Babies Under Two Years In Mandailing Natal Districts North Sumatra
Authors: Nasution Zuraidah , Mahdiah Mahdiah , Nurhayati Ida , Zahara Ratna , Irianti Evi , Doloksaribu Tetty Herta
Published: October 2023

Background: Stunting is a condition in which growth and development is disrupted by children caused by chronic malnutrition. This study aims to determine the relationship between exclusive breastfeeding and the age of complementary feeding (MP-ASI) with the incidence of stunting. This study uses a quantitative approach with secondary data analysis and tested by chi-square with the sample. The statistical results show a value of p = 0.05. This study can be concluded that there is a relationship between the age of complementary feeding (MP-ASI) and the incidence of stunting. In other words, it is said that the sooner prelactal food is given, the easier it is for stunting to occur in children aged 0-2 years. The statistical results show p = 1,000, this shows that there is no relationship between exclusive breastfeeding and the incidence of stunting
Inflammatory Fibroid Polyp of the Caecum in a Patient with Neurofibromatosis
Authors: Ng C , Lam KY , Gupta TS , Ho YH
Published: October 2023

Introduction: Inflammatory fibroid polyp of the large intestine is uncommon. To our knowledge, this condition has not been reported in a patient with neurofibromatosis.

Clinical Picture: In this report, a 66-year-old woman with neurofibromatosis was found to have a large polyp in the caecum.

Treatment: Right hemicolectomy was performed because of the size of the polyp.
Outcome: Pathological examination showed that the polyp was an inflammatory fibroid polyp.

Conclusion: Clinicians should be aware that inflammatory fibroid polyps could be one of the many manifestations of neurofibromatosis in the gastrointestinal tract.
Clinico-pathological Analysis of Myelodysplastic Syndromes According to French-American-British Classification and International Prognostic Scoring System
Authors: Lau LG , Chng WJ , Liu TC , Tan LK , Ong KH , Mow BMF , Kueh YK
Published: October 2023

Introduction: The aim of this study was to analyse the clinico-pathological features of a cohort of patients with myelodysplastic syndromes (MDS).

Materials and Methods: The clinical and pathological data of 43 MDS patients over a 3-year period were reviewed. Survival analysis was performed according to the French-American-British (FAB) classification and International Prognostic Scoring System (IPSS) using the Kaplan-Meier method. Selected published studies for comparison were identified from MEDLINE search.

Results: The patients were followed up for a median duration of 175 days (range, 2 to 1044 days). The median survival for refractory anaemia (RA) and refractory anaemia with ringed sideroblasts (RARS) has not been reached, but that for refractory anaemia with excess blasts (RAEB), refractory anaemia with excess blasts in transformation (RAEB-T) and chronic myelomonocytic leukaemia (CMML) was 250 days, 49 days and 44 days, respectively. The median survival for the low-risk and intermediate-1 IPSS categories has not been reached, while that for the intermediate-2 and high-risk categories was 58 days and 49 days, respectively. The survival analyses, according to the FAB classification and IPSS system, were statistically significant (P <0.05). Comparison of our data with those from neighbouring and Western countries revealed both similarity and disparity. We also noted different cytogenetic information in our cohort of patients.

Conclusions: We found distinctly unique cytogenetic and clinico-pathological characteristics in our MDS patients. However, whether true biological differences exist among MDS patients in different geographies and populations with different genetic and environmental backgrounds require further large multinational study.
Casemix in Singapore – 5 Years On
Authors: Lim EK , Lee CE
Published: October 2023

The development of casemix classification systems started in the late 1960s when clinicians at the Yale-New Haven Medical Centre asked Professor Robert Fetter of Yale University for help with the identification of aberrant cases in utilisation review. Professor Fetter argued that in order to identify the aberrant, you had first to identify the normal, hence the advent of casemix classification systems.
Stem Cell and Cartilage in Orthopaedics
Authors: Shafi Mohamed , Hui JHP
Published: October 2023

In the past decade, much has been learnt about the regeneration and repair of skeletal tissues. Regeneration involves slow replacement of tissues with identical tissue. It occurs readily in the embryo, hardly at all in neonates, and is never observed in adults. In 1743 Hunter¹ stated, “From Hippocrates to the present age it is universally allowed that ulcerated cartilage is a troublesome thing and that, once destroyed, is not repaired.” A now extensive knowledge base of both repair and regeneration in orthopaedics tissues has enabled the development of new and innovative treatment modalities.
Testing The Theory Of Planned Behavior And Perceived Risk To Predict Intention To Used Of Pay Later Services
Authors: Lubi Ach. , Sanaji Sanaji
Published: October 2023

The phenomenon of increasing pay later consumers significantly from year to year has made many companies engaged in the technology industry vying to provide pay later services. However, from this there was a massive arrears made by consumers. Based on this phenomenon, the purpose of the authors in conducting this research is to determine the preference for the intention of using fintech and e-commerce consumers for pay later services by using TPB as a reference for this research and then adding one independent variable, namely perceived risk. This study use online survey and data will be analyzed using multiple regression analysis. The results of this study indicate that attitudes, subjective norms, perceived behavioral control, and perceived risk have a positive effect on the intention to use pay later services. Meanwhile, perceived risk has the smallest effect on the intention to use pay later services.
The Influence of eWOM and Brand Image on Brand Trust and Purchase Intention of Mixue Ice Cream & Tea Consumers in the Special Region of Yogyakarta
Authors: Marziqah Raihanah , Albari Albari
Published: October 2023

This research aims to explain the influence of electronic word of mouth (eWOM), brand image, brand trust, and consumer purchase intention on Mixue ice cream and tea. The respondents of this study were 190 individuals from the Yogyakarta Special Region, aged between 15 and 50 years old. Convenience sampling technique was used for sample selection, and the structural equation modeling (SEM) analysis technique was employed to test the model and hypotheses. The testing was conducted using Smart PLS Version 3.2.9 software. The results of this study indicate that eWOM has a positive and significant influence on purchase intention. eWOM also has a positive and significant influence on brand image, and a positive and significant influence on brand trust. Brand image has a positive and significant influence on brand trust, and a positive and significant influence on purchase intention. Lastly, brand trust has a positive and significant influence on purchase intention.
Igniting the IT Flame: a Study on IT Skills and Knowledge in Accounting Programs Among Graduating Students in Oman
Authors: Alshuriqi Shatha Hilal , Al Mahrouqi Balqees Saed , Thottoli Mohammed Muneerali
Published: October 2023

Purpose: Accountants have always been information technology (IT) users, and the case for increasing IT skills and Knowledge by accounting practitioners and graduates is stronger than ever. In business, IT is widely used and is getting more so. Without IT tools, achieving users' requirements for financial statements and other management information systems reports is no longer possible. Academics and practitioners have recognized the significance and IT (skills and Knowledge) in achieving success in the competitive business environment. Accountants who work for businesses, IT (skills and Knowledge) have necessitated the development of a new type of accountant, which is the focus of this study. Hence, this study aims to know the relationship between IT (skills and Knowledge) of accounting graduating students in Oman and university accounting programs.

Design/ Methodology/ Approach: The units of analysis for this study are graduating students in Oman. It used a survey for the year 2022 to study the effect of IT (skills and Knowledge) and accounting programs among graduating students in Oman. The present research tested its hypotheses and utilized its variables using the PLS software for data analysis.

Findings: The result revealed that IT Knowledge was significant with Accounting Programs where it was p<0.01, t ˃2.33. This result indicates that IT Knowledge has a significant impact on Accounting Programs. Further, the result revealed that IT Skills were also significant in Accounting Programs where it was p< 0.01, t=2.434. This result indicates that IT Skills have a significant impact on Accounting Programs.
FORMAÇÃO DE PREÇO DE SERVIÇO BASEADO EM CUSTOS: APLICAÇÃO PRÁTICA EM EMPRESA DE ADMINISTRAÇÃO DE CONDOMINIAL
Authors: Mota de Oliveira Paloma , Sena Thiago Rios
Published: October 2023

Estabelecer o preço de venda é um dos maiores desafios enfrentados pelos gestores e a precificação baseada em custos pode auxiliar a empresa na identificação dos gastos para alcançar os resultados esperados. Esta pesquisa tem como objetivo realizar a precificação de serviços baseada em custos de uma empresa de pequeno porte do ramo de administração de condomínios. Para isso, realizou-se um estudo de caso em uma empresa atuante no município de Salvador (BA), utilizando abordagens quantitativa e qualitativa. Os resultados encontrados demonstram que a empresa analisada não pratica nenhum tipo de controle formal dos seus gastos e foi sugerido um novo modelo de precificação baseado em custos para atingir a lucratividade esperada pelos gestores utilizando o markup. Este estudo apresenta como contribuições acadêmicas e sociais a aplicação prática da precificação baseada em custos, dessa maneira os gestores e potenciais clientes podem utilizar essas informações no processo de negociação de preços de serviços de administração condominial.
GESTÃO DE CUSTOS EM UMA PEQUENA PROPRIEDADE RURAL FAMILIAR: ANÁLISE DO CUSTEIO VARIÁVEL E ABSORÇÃO NA PRODUÇÃO DE MILHO E SOJA
Authors: Pedroso Karla Cristina , Pavão Juliane Andressa , Rivelino Martins Ribeiro Roberto , Neumann Marguit
Published: October 2023

O estudo teve como objetivo analisar as ferramentas de custeio variável e custeio por absorção em uma pequena propriedade rural familiar na produção de milho e soja. Os dados para realização da pesquisa foram obtidos por meio de entrevista com o produtor rural, relatórios emitidos pela cooperativa na qual o produtor compra os insumos e vende sua produção, e por meio de relatórios emitidos pelo banco. Com relação aos métodos de pesquisa foram classificadas como descritiva e aplicada, sendo que a abordagem do problema foi qualitativa e quantitativa, considerada uma pesquisa ex-post facto e o ambiente de pesquisa foi o campo. Concluiu-se que o produtor obteve maior custo total na produção de soja do que na produção de milho. Em relação as demonstrações de resultados, a soja obteve maior rentabilidade tendo o mesmo resultado nos dois métodos de custeio. Com relação ao ponto de equilíbrio contábil da soja, observou-se que é a quantidade de 123,75 sacas e a quantidade de 272,48 sacas para o milho. Já em relação ao ponto de equilíbrio econômico obteve-se o número de 843,73 sacas de soja e 1.681,57 sacas de milho. A alavancagem operacional revelou que a soja obteve a maior rentabilidade em comparação com o milho. A pesquisa possibilitou demonstrar a importância da gestão de custos na produção agrícola da pequena propriedade rural, gerando informações que contribuam para o processo decisório do produtor rural.
CUSTO DA PRODUÇÃO LEITEIRA EM UNIDADES DE AGRICULTURA FAMILIAR
Authors: Vaz Fabiano Nunes , Rosback João Augusto Rubin , Boscardin Mariele
Published: October 2023

O presente trabalho teve como objetivo analisar os custos da produção de leite em unidades de agricultura familiar, gerando informações sobre os custos da atividade leiteira, de forma comparativa. O método utilizado foi um estudo multicaso, envolvendo quatro unidades de produção leiteiras (UPLs) localizadas em dois municípios do Rio Grande do Sul, com áreas variando entre 15,6 e 91,0 hectares. Nas entrevistas foi feito o inventário patrimonial e relacionados os gastos e as receitas durante o ano. Observou-se que os maiores gastos dos produtores de leite estudados se referem a alimentação dos rebanhos, sendo que 70,05% a 85,68% do custo efetivo são gastos com concentrados, pastagens e silagens. Também se verificou que três das quatro UPLs possuem viabilidade econômica dos sistemas produtivos, com variação de R$ 6.698,55 e R$ 107.148,40 por ano. As lucratividades calculadas oscilaram entre 16,1% e 24,3% da receita bruta. Também se analisou que o investimento em tecnificação e estruturação demanda maior eficiência do sistema para absorver os custos, bem como se identificou que é possível obter níveis de produção satisfatórios em um sistema menos tecnificado, aproveitando o custo relativamente baixo da mão de obra familiar. Conclui-se que a produção leiteira precisa gerar uma produção superior a  5.932,94 litros por hectare para que ocorra remuneração da terra, trabalho e capital empregados na produção de leite em todas as UPLs.