bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical implications of PON1 (rs662) and TNF-α (rs1799964) genes polymorphism in patients with coronary artery disease
Authors: Raza Syed Tasleem , Abbas Shania , Wani Irshad Ahmad , Eba Ale , Mahdi Farzana
Published: July 2022

Background

Coronary artery disease (CAD) is the most common kind of heart problem, currently became one of the leading causes of death worldwide and is predicted to persist so for the next 20 years. The global risk factors to CAD include atherosclerosis, genetic predisposition, environment and the lifestyle. This study is aimed to find out the genotypic association of PON1 (rs662) and TNF-α (rs1799964) genes with CAD among North Indian populations. A total of 330 subjects including 175 CAD cases and 155 healthy controls were enrolled in this study. Single nucleotide polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) method. χ2 and Student's t-tests were applied for the comparison of alleles and genotype frequencies in cases and controls. Logistic regression analysis was applied to calculate the 95% confidence intervals and odds ratios (OR) for assessing the association of genotype with disease.

Results

The PON1 gene QQ, QR, RR genotypes frequencies were 36.57%, 50.29%, 13.14% in CAD cases and 60%, 38.71%, 1.29% in controls, respectively. OR for the genotype QQ, QR, RR was 0.38, 1.6, 11.57 (P < 0.001, P = 0.035, P < 0.001). The TNF-α gene CC, CT, TT genotypes frequencies in cases were 4.57%, 50.29%, 45.14% and controls 3.23%, 46.45%, 50.32%, respectively. OR for CC, CT, TT genotype was 1.437, 1.166, 0.812 (P = 0.531, P = 0.487, P = 0.347). We found significant difference in the genotype and allele frequencies of PON1 gene between cases and control, while no significant difference was observed in TNF-α gene between cases and control.

Conclusions

The PON1 (rs662) gene polymorphisms were significantly associated with an elevated risk of CAD, while no significant association was observed with TNF-α (rs1799964) gene polymorphism and the risk of CAD.
Investigation of the relationship between perceived social support and body image in women with breast cancer
Authors: Doori Zahra , Hekmat Khadijeh , Mousavi Parvaneh , Latifi Seyed Mahmood , Shahbazian Hojatollah
Published: July 2022

Background

Patients with breast cancer have more body image disorders than healthy individuals. The present study aimed to determine the relationship between perceived social support and body image in women with breast cancer. This descriptive-analytical study was performed on 192 women with breast cancer undergoing mastectomy or tumor resection with breast preservation referred to Golestan Hospital in Ahvaz from February 2016 to May 2017. Data collection tools included Demographic Information, Perceived Social Support, and Multidimensional Body-Self Relationship Questionnaires (MBSRQ). Data analysis was performed using SPSS 22 and Pearson correlation coefficient and multivariate linear regression. A p value less than 0.05 was considered significant.

Results

The Pearson correlation test showed a positive and significant relationship between perceived social support from family, friends, and leading people and body image in mastectomy (r 0.81) and tumor resection groups with breast preservation (r 0.78) (p < 0.001).

Conclusion

The results showed a direct relationship between perceived social support and body image in women with breast cancer. Accordingly, by educating patients and their families and medical staff about the importance of perceived social support, it is possible to help improve the dimensions of social support in these patients and improve the body image of these patients.
Symmetry and financial markets
Authors: Andersen Jorgen Vitting , Nowak Andrzej
Published: July 2022

It is hard to overstate the importance that the concept of symmetry has had in every field of physics, a fact alluded to by the Nobel Prize winner P.W. Anderson, who once wrote that “physics is the study of symmetry”. Whereas the idea of symmetry is widely used in science in general, very few (if not almost no) applications has found its way into the field of finance. Still, the phenomenon appears relevant in terms of for example the symmetry of strategies that can happen in the decision making to buy or sell financial shares. Game theory is therefore one obvious avenue where to look for symmetry, but as will be shown, also technical analysis and long term economic growth could be phenomena which show the hallmark of a symmetry.
Ανάπτυξη δεοντολογικών προτύπων για τα ΜΜΕ
Authors: Βασιλόπουλος Βασίλειος
Published: July 2022

Σκοπός της ερευνητικής εργασίας ήταν να εντοπίσει και στη συνέχεια να συνθέσει τα αυτορρυθμιστικά πρότυπα που θα μπορούσαν ως ήπιο δίκαιο να επηρεάσουν ένα Μέσο ενημέρωσης στην κατεύθυνση της ανεξαρτησίας, της διαφάνειας, της λογοδοσίας, της ποιότητας, της δεοντολογίας και της επιχειρηματικότητας. Ενταγμένη στο θεωρητικό πλαίσιο της Ηθικής και Δεοντολογίας υπό την οπτική της Διακυβέρνησης των Μέσων, η μελέτη στοχεύει στην ενοποίηση σε ένα κοινό πλαίσιο τις ηθικές υποχρεώσεις, τόσο της εταιρικής διοίκησης, όσο και της δημοσιογραφικής διεύθυνσης, διαθέτοντας σε αυτές ένα νέο εργαλείο επιθεώρησης, μέτρησης και πιστοποίησης της συμμόρφωσης με τη δεοντολογία. Για την επίτευξη του στόχου της αξιοποίησης της δεοντολογίας ως soft law αυτορρυθμιστικού εργαλείου διακυβέρνησης στα ΜΜΕ, μέσω της ανάπτυξης ενός Προτύπου Δεοντολογίας, μελετήθηκε ο ρόλος της δεοντολογίας ως αξία στο οικοσύστημα της Βιομηχανίας των Μέσων. Ζητήθηκε από ειδικούς, δημοσιογράφους, εκπροσώπους εκδοτών, πανεπιστημιακούς και συμβούλους πιστοποίησης, η συμβολή τους για τον εντοπισμό κοινής αποδοχής προτύπων ποιότητας δημοσιογραφικού έργου και δεοντολογίας. Επιχειρήθηκε, με την υπαγωγή των κανόνων του Δεοντολογικού Προτύπου του Κώδικα Ηθικής από το Ερευνητικό Κέντρο Αθηνά, στο Πρότυπο ISO 9001, ένα νέο Σύστημα Διαχείρισης Δεοντολογίας και Ποιότητας Διακυβέρνησης των Μέσων που μπορεί να εφαρμοστεί σε κάθε εκδοτικό οργανισμό ανεξάρτητα από το μέγεθός του, το θεματικό του πεδίο, τη μορφή διανομής περιεχομένου και το νομικό, ρυθμιστικό και εξωτερικό περιβάλλον των εμπλεκόμενων μερών. Το αποτέλεσμα δεσμεύει την εταιρική διοίκηση σε θέματα ηθικής στο 70% των απαιτήσεων και δεν επιφέρει περισσότερο γραφειοκρατικό βάρος στην εταιρική διακυβέρνηση.
The contribution of adult education to economic development
Authors: Χατζημιχαηλίδου Παναγιώτα
Published: July 2022

Η παρούσα μελέτη διερευνά τον ρόλο της εκπαίδευσης ενηλίκων στην οικονομική ανάπτυξη στο πλαίσιο της Διεθνούς Πολιτικής Οικονομίας. Για το σκοπό αυτό πραγματοποιήθηκε μελέτη περίπτωσης στην Ε.Ε. προκειμένου να διερευνηθεί ο ρόλος των τριών θεσμικών ρυθμίσεων, δηλ. του κράτους, της αγοράς και της κοινωνίας των πολιτών τόσο στη διαμόρφωση της πολιτικής για την εκπαίδευση ενηλίκων, όσο και στη διαδικασία μετασχηματισμού των νοητικών σχημάτων και των νοητικών θεωρήσεων των ενήλικων εκπαιδευομένων, η οποία ανοίγει το δρόμο για μια βαθύτερη κατανόηση της αλληλεπίδρασης μεταξύ του ατόμου και της κοινωνικής δράσης προς την οικονομική ανάπτυξη. Η τελευταία ταυτίζεται με την ευφορία, που σημαίνει βελτίωση των συνθηκών διαβίωσης των κατοίκων που ζουν εντός της επικράτειας ή με άλλα λόγια ότι η ζωή τους βελτιώνεται. Η προσέγγιση του Κονστρουκτιβισμού και η Θεωρία της Μετασχηματίζουσας Μάθησης είναι η προτεινόμενη θεωρητική βάση για την εξήγηση του τρόπου με τον οποίο η εκπαίδευση ενηλίκων συσχετίζεται με την οικονομική ανάπτυξη μέσω της συμμετοχής ενηλίκων εκπαιδευομένων. Η οικονομική ανάπτυξη μπορεί να έχει θετικό αντίκτυπο στην ενοποίηση της Ευρώπης, μια ιδέα που υποστηρίζεται από αυτή τη μελέτη, η οποία περιλαμβάνει οικονομικές, πολιτικές και πολιτιστικές συνιστώσες.
Πολιτικές χειραφέτησης
Authors: Τατίδου Σοφία
Published: July 2022

Η παρούσα διατριβή αποσκοπεί στη διερεύνηση της γυναικείας χειραφέτησης σε μια κομβική -ως προς αυτό το ζήτημα- περίοδο της ιστορίας του σύγχρονου κόσμου. Πρόκειται για το «γύρισμα» ανάμεσα στον 19ο και στον 20ό αιώνα, όταν οι νέες συνθήκες ζωής επαναπροσδιορίζουν τη θέση των γυναικών στον νέο κόσμο που προοδευτικά παγιώνεται και δημιουργούν τους όρους και τις προϋποθέσεις για την κοινωνική και πολιτική τους χειραφέτηση. Η έρευνα επικεντρώνεται στις «τεχνικές», στις διαδρομές, στις μεθόδους που ακολουθεί αυτή η πορεία και, πιο ειδικά, σε ένα φαινόμενο που απασχόλησε έντονα την επιστήμη αλλά και το κοινό αίσθημα εκείνα τα χρόνια της μετάβασης: πρόκειται για το φαινόμενο των γυναικείων αυτοκτονιών, το οποίο εντάθηκε σε τέτοιο βαθμό, ώστε οδήγησε στη διατύπωση του όρου «επιδημίες αυτοκτονιών». Επιδημίες που αφορούσαν σε πρώτο λόγο τις αυτοκτονίες-διακηρύξεις που συνδέονταν με τη διεκδίκηση των προσωπικών ή των κοινωνικών τους δικαιωμάτων.
The potential utility of an augmented data collection approach in understanding the journey to care of pregnant women for maternal and perinatal death surveillance and response
Authors: Banke-Thomas Aduragbemi
Published: July 2022

Background: The Maternal and Perinatal Death Surveillance and Response (MPDSR) proposed by the World Health Organization recognises the importance for health systems to understand the reasons underpinning the death of a pregnant woman or her newborn as an essential first step in preventing future similar deaths. Data for the surveillance component of the MPDSR process are typically collected from health facility sources and post-mortem interviews with affected families, though it may be traumatising to them. This brief report aimed to assess the potential utility of an augmented data collection method for mapping journeys of maternal and perinatal deaths, which does not require sourcing additional information from grieving family members.

Methods: A descriptive analysis of maternal and perinatal deaths that occurred across all 24 public hospitals in Lagos State, Nigeria, between 1st November 2018 and 30th October 2019 was conducted. Data on their demographic, obstetric history and complication at presentation, travel to the hospital, and mode of birth were extracted from their hospital records. The extracted travel data was exported to Google Maps, where driving distance and travel time to the hospital for the period of the day of travel were also extracted.

Results: Of the 182 maternal deaths, most presented during the week (80.8%), travelled 5-10 km (30.6%) and 10-29 minutes (46.9%), and travelled to the nearest hospital to their places of residence (70.9%). Of the 442 pregnant women who had perinatal deaths, most presented during the week (78.5%), travelled <5 km (26.9%) and 10-29 minutes (38.0%). For both, the least reported travel data was the mode of travel used to care (>90.0%) and the period of the day they travelled (approximately 30.0%).

Conclusion: An augmented data collection approach that includes accurate and complete travel data and closer-to-reality estimates of travel time and distance can be beneficial for MPDSR purposes.
Impact of a postgraduate year one (PGY-1) otolaryngology bootcamp on procedural skill development
Authors: Wajsberg Benjamin , Li Daniel , Kohanzadeh Avraham , Bitners Anna C. , Gorthey Scott , Gibber Marc J. , Rong Esther , Bent John P. , Gangar Mona , Yang Christina J.
Published: July 2022

Background: To measure the impact of an intensive eight-week postgraduate year one (PGY-1) otolaryngology bootcamp on the acquisition and retention of otolaryngology residents’ procedural skills compared to the traditional method of skill acquisition through clinical exposure.

Methods: Residents at our institution were evaluated on their performance of flexible laryngoscopy, suture ligature, and rigid bronchoscopy setup at three time points: pre-bootcamp, one-week post-bootcamp, and one-year post-bootcamp. Video recordings were scored by two blinded faculty reviewers using a multipoint rating system. A control group of rising postgraduate year two (PGY-2) residents who did not participate in bootcamp were recorded performing these same skills. Scores in the three skills were compared between groups via t-tests. The eight-week bootcamp curriculum for PGY-1s was held at the Montefiore Einstein Center for Innovation in Simulation at Albert Einstein College of Medicine/Montefiore Medical Center. The participants were two classes of PGY-1 residents (n=8) at our institution who participated in a bootcamp at the beginning of residency, and one class of rising PGY-2 residents (n=3) who did not participate in a bootcamp (control group).

Results: A comparison of pre-bootcamp scores to one-week post-bootcamp scores showed significant improvement in suture ligature (P<0.05) and rigid bronchoscopy (P<0.05), but no difference in flexible laryngoscopy (P=0.54). Suture ligature (P=0.09) and rigid bronchoscopy (P=0.25) skills were not significantly different from one-week post-bootcamp to one-year post-bootcamp; however, a significant skill improvement was observed in flexible laryngoscopy (P<0.05). By June of PGY1 year, the two bootcamp cohorts were similar to controls in all three skills: flexible laryngoscopy (P=0.05), rigid bronchoscopy (P=0.26), and suture ligature (P=0.10).

Conclusions: Participation in PGY-1 bootcamp was associated with improved acquisition and short-term retention of basic procedural skills, suggesting that bootcamps can be an effective arena to teach basic skills in otolaryngology. PGY-1 bootcamp is a promising arena for multi-institutional development.
Industrial policy and crisis management enterprises
Authors: Lifshits Arkady , Kulikov Vladimir , Ibragimova Rozaliya , Novikov Viktor
Published: July 2022

Investigated theoretical - methodological and applied problems of industrial policy and crisis management. Substantiates the design mechanisms of structural, investment and innovative development strategies of the region’s industry. It reveals the processes and methods of strategic crisis management. It proved theoretically and practically the leading controlling role as an instrument of crisis management. The results of the testing methods study efficiency standards, planned targets and the extent of tolerance deviations.
The monograph is intended for researchers, managers and specialists of industrial enterprises and public services, professors, teachers and students.
ON THE WAY TO QMS IMPLEMENTATION: THE MAIN MILESTONES AND ISSUES IN EMERGING ECONOMY
Authors: Lebedynets Viacheslav , Prokhorenko Olena , Brin Pavlo , Nehme Mohamad
Published: July 2022

The aim of the research is to analyze typical problems in the implementation of quality management systems (QMS) on the basis of private production enterprises which operate in emerging economy context and to develop a rational strategic plan for the design and implementation of such a system, taking into account the experience of successful organizations. The main benefits of implementing QMS are presented. In the article it is recommended to consider the formation of QMS as a project with the appropriate stages of activities. The following positions are envisaged at the initiation stage: formalization of the decision on QMS implementation, appointment of project participants, project team training, as well as development of mission, vision, quality policy and QMS process structure. At the implementation stage, it is proposed to develop and approve QMS documents, as well as to implement an internal audit program. At the stage of project closure, it is advisable to put into operation the developed system and pass a certification audit in order to obtain a certificate of compliance with the requirements of ISO 9001. The article presents the structure, content, sequence and estimated duration of all the stages of the project, as well as the division of responsibilities between the project team members. Emphasis is placed on the main issues which can arise at different stages of such a project. In the paper the following range of issues was identified: inconsistency of QMS processes structure with the existing organizational structure of the enterprise; incorrect definition of the performance indicators for processes at different hierarchy levels; erroneous decisions in the internal documentation system organizing. In its turn, in the article the causes for the above-mentioned issues were identified, namely: insufficient motivation of project participants, lack of time or other necessary resources, unwillingness to change the current management system of the company, inconsistency of real goals with the stated ones, etc. In the article it is proposed to divide the main causes of issues into three basic groups: by project participants (personal), bureaucratic (systemic) and leadership (administrative). The authors propose a number of measures to minimize the risks of issues in the QMS implementation, and determine the distribution of areas of responsibility for these measures organizing.
Cigarette Butts Valorization: Activated Hydrochar for Methylene Blue Removal
Authors:   Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand, Phasukarratchai Naphatsarnan , Yattipat Budsarin ,   Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand,   Environmental Science and Technology Program, Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand, Muengkrajang Parichat ,   Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand,   Environmental Science and Technology Program, Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand, Permpoon Sasishai ,   Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand,   Environmental Science and Technology Program, Faculty of Environment and Resource Studies, Mahidol University, Salaya, Phutthamonthon, Nakhon Pathom, 73170, Thailand, Reungsang Alissara ,   Department of Biotechnology, Faculty of Technology, Khon Kaen University, Khon Kaen, 40002, Thailand,   Research Group for Development of Microbial Hydrogen Production Process, Khon Kaen University, Khon Kaen, 40002, Thailand,   Academy of Science, Royal Society of Thailand, Bangkok, 10300, Thailand
Published: July 2022

Cigarette butts (CB) are a toxic waste that is harmful to both environment and health. This research utilized CB as activated carbon (AC) to adsorb methylene blue (MB). The AC production involved the conversion of CB to hydrochar (HC) followed by activation with KOH. The production of HC by hydrothermal carbonization, determined using a central composite robust design (CCRD),was found to be at 200° C for 5.83 h. The AC prepared from HC had a maximal MB adsorption efficiency of 97.49% from an initial MB concentration of 150 mg/L. AC, HC, and CB had significantly different MB removal efficiencies of 97.49%, 7.03% and 6.93%, respectively. The adsorption isotherm of AC with MB fit with Langmuir isotherm absorption which demonstrated that MB is adsorbed on the AC surface by chemical bonding with a single layer. By analyzing the functional groups of organic compounds using FTIR, no carbonyl groups were found in HC which indicates the destructure of cellulose-acetate. Moreover, the weight loss during measured during TGA shows that the mass composition in AC is mostly carbon black. These results show the potential of using AC prepared from waste cigarette butts as an adsorbent to removal color contaminants from water.
Development of Sequential Injection Analysis for the Determination of Lead in Vegetables
Authors:   Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand, Wonganan Tharinee , Chaiyasing Kanokwan ,   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand, Liawruangrath Boonsom ,   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand,   Cosmetic Technology, Faculty of Science and Technology, North-Chiang Mai University 52000, Thailand, Rannurags Narabhats ,   Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand, Liawruangrath Saisunee ,   Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand,   Center of Excellent in Materials Science and Technology, Chiang Mai University, Chiang Mai 50200, Thailand
Published: July 2022

A sequential injection analysis incorporated with spectrophotometric method was developed for determination of lead, based on reaction of dithizone with lead producing pink complex and absorbance of the complex was measured at 515 nm. The analytical parameters of the system were optimized by univariate method such as reagent concentration, fl ow rate of reagent and injection volume. Linear calibration curve over the range of 0.02-0.08 mg L-1 and 0.1-2.0 mg L-1 lead was obtained. The detection limit of lead was 0.012 mg L-1. The relative standard deviations for fi ve replicate injections was 0.77-1.54% for intra-day and 0.86-1.80% for inter-day. The recovery of 98.75-101.20% was achieved with sample throughput of 45 samples per hour. The proposed method has been applied to the determination of lead in vegetable samples. The obtained results were in good agreement with those obtained by the ICP-MS standard method, verifi ed by the student t-test at the 95% confi dence level.
Qualidade de Vida Capacidade Funcional de Idosos Fisicamente Ativos: Possíveis Relações
Authors: Vicentini de Oliveira Daniel , Martins Peres Priscila , Rosas Moreira Caio , Aguiar Pereira Daniel , Assis Silva Nathaly , Silva Sherdson Emanuel , Andrade do Nascimento Júnior José Roberto
Published: July 2022

Objetivo: investigar a relação entre a qualidade de vida (QV) e a capacidade funcional de idosos fisicamente ativos. Materiais e Métodos: Estudo transversal realizado com 73 idosos de ambos os sexos. Foi utilizado o Questionário Internacional de Atividade Física (IPAQ), o WHOQOL-Bref e Old, Escala de Katz e Escala de Lawton. Para análise dos dados foram utilizados os testes de Kolmogorov-Smirnov, "U" de Mann-Whitney e a correlação de Spearman. Resultados: Os idosos irregularmente ativos percebem melhor QV em relação aos aspectos psicológicos (p=0,074) e à intimidade (p=0,017) em detrimento aos idosos muito ativos/ativos. Verificou-se correlação das atividades básicas de vida diária com os domínios físico (r=0,32), psicológico (r=0,35) da QV, e as facetas de funcionamentos dos sentidos (r=0,34) e participação pessoal (r=0,35). Já as atividades instrumentais de vida diária apresentaram correlação significativa com os domínios físico (r=0,45), psicológico (r=0,52), relações sociais (r=0,34) e auto avaliação (r=0,49) da QV, e as facetas de autonomia (r=0,33), participação pessoal (r=0,46) e morte e morrer (r=0,46). Conclusão: Conclui-se que o há relação entre o aumento da capacidade funcional e o aumento da percepção de qualidade de vida em idosos fisicamente ativos.
Utilização das terminologias urgência e emergência em odontologia no contexto da pandemia da COVID-19: Uma revisão de escopo
Authors: Schiochet Gabriela Fernanda , Jagas Neves Gabrielle , Galvan Jessica , De Souza Martins Alessandra , Bucholdz Teixeira Alves Fabiana , Berger Fadel Cristina
Published: July 2022

Introdução: Após o surto da COVID-19, a área odontológica conhecida pelo contato próximo profissional-paciente, logo foi identificada como um cenário de alto potencial de contaminação pelo Sars-CoV-2. Com isso, decisões governamentais foram tomadas com vistas à paralisação dos serviços de rotina de saúde bucal em diversos países. No entanto, as necessidades odontológicas de atendimento de urgência e emergência puderam ser mantidas. Assim, a interpretação dos conceitos do que poderia ou não ser realizado no atendimento odontológico, gerou dúvidas entre os profissionais da saúde bucal no contexto da pandemia do COVID-19. Objetivo: Relacionar o modo de utilização dos termos urgência e emergência odontológica no contexto da pandemia da COVID-19. Materiais e Métodos: Foi realizada uma revisão de escopo seguindo a metodologia do Joanna Briggs Institute (JBI). Foram considerados artigos publicados em português, inglês e espanhol, nas plataformas MEDLINE/PubMed, SCOPUS (Elsevier), Web of Science e EMBASE (Elsevier). Resultados: Foram localizados 959 estudos e incluídos 48 destes. Os resultados encontrados demonstram que muitas definições se repetem pelos autores nas utilizações dos termos urgência odontológica e emergência odontológica. Conclusão: O conceito e aplicação das terminologias urgência odontológica e emergência odontológica ainda não se encontram totalmente consolidados por acadêmicos e profissionais da saúde bucal, sendo muitas vezes utilizadas como sinônimos. Tal fato dificulta a sua interpretação e padronização em estudos científicos, além de desencadear possíveis prejuízos aos serviços que adotam classificação de casos segundo escala de gravidade, preconizadas por diversos órgãos de saúde, em especial o Ministério da Saúde do Brasil.
Composição corporal e fatores associados à doença cronônica venosa em pacientes submetidos à cirurgia de varizes em membros inferiores
Authors: Ballerini Ana Paula , Neves Lucas , Novo Neil , Tonhosolo Renata , França Carolina Nunes
Published: July 2022

Introdução: A doença varicosa em membros inferiores é uma patologia de alta prevalência na população, e diversos fatores são relacionados com seu aparecimento e evolução. Objetivo: avaliar a associação da alteração na composição corporal a fatores associados à doença crônica vascular (DCV) com varizes de membros inferiores. Métodos: trata-se de estudo transversal, prospectivo, com pacientes submetidos à cirurgia de varizes de membros inferiores em hospital referência, no período de maio a novembro de 2018. Utilizou-se instrumento de pesquisa semiestruturado com questões que abordavam fatores associados a DVC. Para análise dos dados foram utilizados os testes qui-quadrado de Pearson e Teste Exato de Fisher, além do Teste de Concordância de Kendall. Resultados: Foram selecionados 146 indivíduos, dos quais 89% do sexo feminino, e com idade média de 48,89 anos. A grande maioria (76%) apresentava história familiar de doença venosa, não possuía história de úlceras venosas, tromboembolismo venoso individual e familiar ou cirurgias anteriores. Além disso, mais de 50% não realizava atividade física, e 65% encontravam-se em sobrepeso ou obesidade. Quando analisados estatisticamente, os fatores não diferiram entre não-eutróficos e eutróficos. O Teste de Concordância de Kendall mostrou boa correlação entre a ordem de aparecimento dos fatores entre todos os grupos estudados. Conclusões: Os fatores associados mais prevalentes na população estudada foram a presença de história familiar de varizes em membros inferiores, sexo feminino e presença de sobrepeso/obesidade. A presença de alteração do peso corporal não determinou diferenças na ocorrência e aparecimento dos fatores avaliados.
Evolução dos cadastros individuais no SISAB a partir do novo financiamento da atenção básica: Um estudo descritivo
Authors: Lopes Síntique Priscila Alves , Araujo Juliana de Sousa , Figueiredo Laís Gomes Martins , Almeida Michele Alcântara de , Araújo Bianca Lís Souza , Moreira Marcela Beatriz Aguiar , Cangussu Maria Cristina Teixeira Cangussu
Published: July 2022

Introdução: Compreende-se que o novo financiamento da Atenção Básica através do Previne Brasil instituído em novembro de 2019, implicou na necessidade de cadastros individuais como premissa para repasse de recursos aos municípios. Objetivo: Este estudo pretende evidenciar a evolução do número de cadastros individuais entre os estados do Nordeste no período entre o terceiro quadrimestre de 2019 (2019Q3) e o terceiro quadrimestre de 2020 (2020Q3). Materiais e métodos: Trata-se de um estudo transversal descritivo de natureza quantitativa pautado em dados secundários coletados do Sistema de Informação da Atenção Básica (SISAB) entre fevereiro e março de 2021. Resultados: A Bahia apresentou maior evolução no número de cadastros com percentual equivalente a 7,12% enquanto o Ceará não apresentou crescimento no número de cadastros. Os outros estados que compõem a região Nordeste, não apresentaram variação crescente superior a 4%.  Conclusão: Em um ano de implantação do Programa, observou-se que a evolução dos cadastros ainda é incipiente, sendo necessárias novas investigações junto aos municípios a fim de serem levantadas estratégias para incremento dos cadastros individuais e por conseguinte manutenção do custeio da Atenção Primária à Saúde.
The Triple Helix in transition economies and Skolkovo: a Russian innovation ecosystem case
Authors: Chekanov Alexander
Published: July 2022

Public administrations undertake initiatives to foster knowledge ecosystems in scientific and technology hotspots. It is assumed that innovation ecosystems will create value networks through which participants can develop and commercialize their value propositions. Value networks refer to innovation ecosystems where the final product or service is offered by a constellation of businesses that complement each other. The innovation ecosystems literature suggests that innovation ecosystems lead to competitive advantages for each of the partners in the ecosystem, creating value for all its actors. Based on a longitudinal case study of the Skolkovo Innovation Center with more than 3000 innovative startups in the Moscow district in Russia, this study explores how value is created in innovation ecosystems in transition economies and the roles of the contributing stakeholders. Through a longitudinal case study and using the Triple Helix framework, this study finds that in transition economies, the state tends to undertake the leading role in establishing the pillars of innovation ecosystems, followed by solid support from state-related industry partners, being the role of universities underrepresented in the initial stages of the ecosystem development. These findings refine the applicability of the triple helix model in transition economies by adjusting the weighting of the different parts of the model when establishing an innovation ecosystem.
Early Evolution of an Innovation District: Origins and Evolution of MID and RMIT University’s Social Innovation Precinct in Melbourne’s City North
Authors: Fernandez Marta , Bentley Tom
Published: July 2022

The development of an urban innovation district requires a unique, densely populated site connecting knowledge-intensive institutions with public spaces, large businesses, startups and SMEs, social hubs, and cultural institutions. Based on conceptual frameworks in the field including urban development theory, quintuple helix model, entrepreneurship and open innovation models, this paper uses a case research study approach, the Melbourne Innovation District. The context is Melbourne’s city centre immediately prior to and during Covid-19 recovery. The work analysed the vision and ambitions for the innovation district, the role of technology and enterprise in place-making and the impact of the pandemic in driving social innovation, the acceleration of demand for a ‘wellbeing economy,’ and incentives for collaboration between institutions. This work contributes to existing literature by examining the evolution and progress of Melbourne Innovation District as a case, and the influence of the 22@ district in Barcelona, highlights practical and strategic insights into how the Melbourne Innovation District formed and built capability for collective strategy in a knowledge-intensive urban settings, and the role of innovation ecosystems to develop dynamic, inclusive urban economies in the pandemic recovery era.
Through this work we observed the key elements for the success in the early development of an innovation district including: the consideration of the real costs of collaboration; the establishment early on of a common vision and a long-term aspiration; the importance of achieving critical mass; the scattered evidence base; the need for ‘anchoring’ project and backbone organisation; the fragmented governance environment; the need for persistence with an integrated vision, that is connected to the overall city strategy; the identification of practical innovations that feed each other and create momentum.
Impact of peers on educational outcomes in Economics
Authors: Abio Gemma , Alcañiz Manuela , Belloni Carlos M. , Gómez-Puig Marta , Ortiz-Gracia Luis , Royuela Vicente , Rubert Glòria , Serrano Mònica , Stoyanova Alexandrina
Published: July 2022

INTRODUCTION. This paper contributes to the study of peer
interactions in the university classroom. METHOD. We evaluate the
effects of teamwork on individual academic performance in four Team
Based Learning (TBL) courses in the degrees of Economics and
Business Administration. RESULTS. We found that the average grade of
the rest of the team members has a significant and positive
association with the grade of the individual student. The student’s
personal test score increases about 0.65 points for every 1-point
increase in the average score of their teammates. This association
remains positive and significant even when we include
socio-demographic variables to control for individual
characteristics. We also tested the heterogeneity of peer effects in
relation to the ability of individual and team performance.
DISCUSSION. The results suggest there is no heterogeneity in
individual ability; however, we found a positive or slightly
negative difference in the magnitude of the peer effect for teams in
the top/bottom quartile compared to teams in the middle of the
distribution.
Infraestruturas de papel: novos instrumentos de financeirização do espaço
Authors: Marostica Stroher Laisa Eleonora , Altavini de Abreu Marlon , Yassu Alexandre , Klink Jeroen Johannes , Cunha Luis Felipe
Published: July 2022

No limiar do novo século, com a intensificação da dominância financeira sobre o sistema capitalista e uma ampliação da busca por novos espaços de acumulação, presenciamos a retomada do debate internacional sobre o padrão de financiamento da infraestrutura. Este artigo explora um conjunto de dados empíricos sobre novos mecanismos do financiamento privado da infraestrutura no Brasil, com ênfase no período pós-2011, em função da disseminação mais expressiva de novos produtos, como as debentures incentivadas de infraestrutura. O primeiro objetivo é explorar o processo de construção da narrativa hegemônica de neoliberalização do Estado para a provisão da infraestrutura, enraizada numa visão binária entre o público e privado. O segundo objetivo relaciona-se aos resultados de nossa pesquisa empírica, a partir dos quais discutimos o neoliberalismo realmente existente, que aponta para um padrão de financiamento emergente marcado pelo hibridismo entre a esfera pública e privada.
Turizmus és reziliencia
Authors: Gonda Tibor
Published: July 2022

A tanulmány a napjainkban egyre több tudományterületen használt reziliencia fogalmát értelmezi, és helyezi a turizmus kontextusába. Bemutatásra kerül a fogalom interdiszciplináris jellege és a különböző tudományágakban megfigyelhető jelentéstartalma. A hazai turizmuskutatás még nem foglalkozik kellő mélységben a kérdéskörrel, és a turizmussal foglalkozó nemzetközi szakirodalomban is csak kevés tanulmányban fordul elő a reziliencia kifejezés. A hazai és nemzetközi szakirodalom vizsgálata során leszűrhető az a következtetés, hogy a reziliencia kérdésének előtérbe kerülése összhangban áll a fenntartható fejlődés törekvésének sikertelenségével. A turizmus, mint világviszonylatban az egyik legdinamikusabban fejlődő gazdasági ágazat, jelentős mértékben felelős a fenntarthatóság megbomlásáért. Az egyes desztinációk olyan népszerűségre tettek szert, hogy kialakult a túlturizmus jelensége, amely – mint láttuk – komoly károkat okozhat a fogadóterület társadalmi és természeti környezetében. Egy-egy fogadóterület természeti és társadalmi szféráját ért hatások vizsgálata kapcsán viszont, elemezve az adott desztináció ellenálló és védekező képességét, a következő időszakban egyre többször fog előtérbe kerülni a reziliencia kérdésköre.
Climate Imperialism in the Twenty-First Century
Authors: Ghosh Jayati , Chakraborty Shouvik , Das Debamanyu
Published: July 2022

Climate imperialism has emerged as a new—and potentially even the most lethal—form of imperialism in the world economy today. Confronting it requires recognizing and dealing with all its different aspects. But it also requires addressing the monopolies of knowledge created by the global regime of intellectual property rights that has been instituted and cemented by hegemonic world powers.
Psychiatric Comorbidities in Epilepsy
Authors: Rodríguez Carlos Arteaga , Kubis Mariana Menine , Arteaga Carlos Bruno Teixeira , Fustes Otto Jesus Hernandez
Published: July 2022

Background and Purpose: Psychiatric comorbidities (PC) occur more frequently in patients with epilepsy than in the general population. To determine the main PC associated with epilepsy and its association with demographic data and clinical features of epilepsy.Methods: A retrospective study was carried out on patients with epilepsy at the Medical Specialties Center of the Municipal Health Department. Demographic data, crisis onset, time range of seizures evolution, type of epileptic seizures, types of epilepsy, etiology, brain injury, topographic location, hemispheric location, type of antiepileptic drugs (AEDs), use of monotherapy or polytherapy, control of epileptic seizures and the PC were recorded.Results: One hundred forty adult patients were studied 51.4% male, mean age 44.9 years, time of evolution of the crises was 14 years, focal crisis 88.6%, mesial temporal sclerosis 42%, controlled 92.4%, monotherapy 66.1%, and the most used AEDs were carbamazepine (33.1%), valproic acid (28.2%), and phenobarbital (10.4%). The PC present in 67.1% of the patients was depression (22.8%), anxiety disorder (AD) (17.8%), psychosis (10%), dementia (9.2%) and bipolar affective disorder (BAD) (8.5%). The relationship between PC and crisis control was significant (p<0.009).Conclusions: Schooling was lower than that reported in the general population in Brazil, and we found a low rate of unemployment or retirement. Epilepsy is associated with PC, the most frequent being depression, AD, psychosis, dementia and BAD. The absence of a relationship between depression and brain damage; anxiety disorder with education, types of epilepsy and etiology; psychosis with sex and time of epilepsy evolution were significant.
The third-generation biodiesel blends corrosion susceptibility of oxide particle-reinforced Si-rich aluminum alloy matrix composites
Authors: Hosseinabadi Navid , Moheimani Navid R.
Published: July 2022

The study of a stir cast Al356-Nb2O5)P composite immersed in third-generation microalgal-derived biodiesel blends with enhanced plasma electrolyte oxidation surface modification revealed the corrosion susceptibility and possible by-product formation. The effect of (oxide)P reinforcement and mixed-oxide surface coatings were studied separately and cumulatively. Samples were immersed in different biodiesel and petrodiesel blends for up to 3000 h, and their corrosion and electrochemical behavior was studied. Although some weight change was recorded in all samples, the corrosion rates significantly decreased from 1.8 to 1.3 by 10 wt% Nb2O5)P reinforcement, which further decreased 10 times after surface modification. Electron microscopy revealed primary fine-grained microstructure with low porosity content of fine and needlelike dendritic structures in composites and irregular volcanic with scattered micropores and microcracks in surface-modified composites that changed to corrosion spots and flake-covered microcracks after immersion.
Graphene-based coatings for magnesium alloys: exploring the correlation between coating architecture, deposition methods, corrosion resistance and materials selection
Authors: Lopes de Oliveira Mara Cristina , Antunes Renato Altobelli
Published: July 2022

Graphene and its derivatives have attracted much interest as corrosion-resistant coatings for magnesium alloys since 2014, when the first reports appeared in the literature. The interest in the use of such carbonaceous compounds to protect magnesium and its alloys from corrosion relies on a set of attributes such as chemical inertness, and high surface area. To support the development of optimized graphene-based films it is imperative to expand the current knowledge toward a deeper understanding of corrosion mechanisms and their interaction with practical aspects related to coating deposition and morphology. In the present work, graphene-based coatings for magnesium alloys are reviewed. We explored the correlation between coating architecture, deposition methods and materials selection using the Ashby approach. The results of the materials selection process revealed that composite coatings consisting of an inorganic matrix obtained by plasma electrolytic oxidation of magnesium alloys and graphene oxide nanosheets as blocking agents can provide surfaces with high corrosion resistance in sodium chloride solution. For biomedical applications, composite coatings consisting of a mixture of organic matrices such as chitosan and graphene oxide as reinforcing particles are attractive candidates. The results are discussed based on coating architecture and its interplay with the corrosion properties.
Status of liquid profiling in precision oncology – the need for integrative diagnostics for successful implementation into standard care
Authors: Froelich Matthias F. , Schoenberg Stefan O. , Neumaier Michael , Haselmann Verena
Published: July 2022

The liquid profiling approach is currently at the threshold of translation from research application in various clinical trials to introduction into the management of cancer patients in the context of clinical care. Routine application has focused primarily on the analysis of single blood-based biomarkers for companion diagnostics. However, liquid profiling promises much broader diagnostic potential, which is discussed and illustrated in this manuscript through several case reports. These clinical cases range from identification of druggable targets to the detection of subclonal resistance mechanisms. In addition, liquid profiling can be used in clinical practice to identify complex molecular patterns or as a personalized tumor marker for patient-specific monitoring of response to treatment. These examples highlight both the value and limitations of liquid profiling in various clinical settings, which could be overcome by an integrative diagnostic approach with imaging techniques. The complementary advantages of both diagnostics approaches will allow combining high sensitivity with genetic tumor profiling and topologic assignment. Therefore, we advocate interdisciplinary integrated collaboration between laboratory and imaging experts to unravel the potentials of precision diagnostics in cancer care.
Liquid profiling for cancer patient stratification in precision medicine – current status and challenges for successful implementation in standard care
Authors: Haselmann Verena , Hedtke Maren , Neumaier Michael
Published: July 2022

Circulating tumor DNA (ctDNA), accurately described by the term liquid profiling (LP), enables real-time assessment of the tumor mutational profile as a minimally invasive test and has therefore rapidly gained traction, particular for the management of cancer patients. By LP, tumor-specific genetic alterations can be determined as part of companion diagnostics to guide selection of appropriate targeted therapeutics. Because LP facilitates longitudinal monitoring of cancer patients, it can be used to detect acquired resistant mechanisms or as a personalized biomarker for earlier detection of disease recurrence, among other applications. However, LP is not yet integrated into routine care to the extent that might be expected. This is due to the lack of harmonization and standardization of preanalytical and analytical workflows, the lack of proper quality controls, limited evidence of its clinical utility, heterogenous study results, the uncertainty of clinicians regarding the value and appropriate indications for LP and its interpretation, and finally, the lack of reimbursement for most LP tests. In this review, the value proposition of LP for cancer patient management and treatment optimization, the current status of implementation in standard care, and the main challenges that need to be overcome are discussed in detail.
Metonymy in the Korean internally headed relative clause construction
Authors: Park Chongwon
Published: July 2022

This article aims to analyze the Korean internally headed relative clause (IHRC) construction from a Cognitive Grammar perspective. The primary issue concerning the Korean IHRC construction is the mismatch between the syntactic object and the semantic head. While the whole embedded clause headed by kes functions as a grammatical object, the semantic head may acquire the object status. I demonstrate that the mismatch is nothing but a metonymic process, just like the mismatch we observe in the loon in the water; even when only the loon’s feet are in the water, the expression is felicitously understood without identifying the particular portion of the loon under water. Just like the speaker accesses the loon’s feet through the loon, she accesses the semantic head through the reified embedded clause in the IHRC construction. I show that adopting this general human cognitive process helps us reach a broader generalization and sheds new light on hitherto neglected examples.
BaFe0.875Re0.125O3−δ
and BaFe0.75Ta0.25O3−δ
as potential cathodes for solid-oxide fuel-cells: a structural study from neutron diffraction data
Authors: García-Ramos Crisanto , Cascos Vanessa , Prado-Gonjal Jesús , Schmidt Rainer , Fernández-Díaz María Teresa , Krezhov Kiril , Alonso José Antonio
Published: July 2022

In this work, two new perovskites of composition BaFe0.875Re0.125O3−δ
and BaFe0.75Ta0.25O3−δ
, designed from ab-initio calculations to fulfill different requisites of cathode materials for solid-oxide fuel cells (SOFC), were prepared and studied from the structural point of view from neutron powder diffraction (NPD) data. They are both derivatives of BaFeO3 hexagonal perovskite (space group P6

3
/mmc), typified as the 6H polytype, stabilized when the perovskite tolerance factor slightly overpasses the unity. Whereas BaFe0.875Re0.125O3−δ
keeps this structural type, as demonstrated in this crystallographic study from NPD data at 295 and 4 K, with unit-cell parameters a = 5.70177(7); c = 14.0334(2) Å at 295 K, the second material, BaFe0.75Ta0.25O3−δ
, is cubic and can be defined in the Pm-3m space group, corresponding of the perovskite arystotype, with a = 4.05876(3) Å. A conspicuous oxygen deficiency is observed, with a refined stoichiometry of 2.86(3) per formula unit. The anisotropic displacement factors for oxygen atoms in this last material are flattened disks perpendicular to the (Fe,Ta)-O-(Fe,Ta) direction, suggesting a dynamic tilting of the octahedra that could be related to the oxygen motion via oxygen vacancies across the structure. This is a pre-requisite for functional mixed-ionic-electronic (MIEC) materials performing as cathodes in SOFC.