bluuebunny/crossref_metadata_2025 huggingface dataset:
A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys
Authors: Chen Dijun , Qu Jiao , Yang Fa , Zhu Tao , Wang Yingshuo , Fang Wen , Ding Yan , Zhao Xue , Qi Xianjia , Xie Qiangmin , Xu Qiang , Xie Yicheng , Sun Yang
Published: February 2022

Non-human primates (NHP) are attractive laboratory animal models that accurately reflect both developmental and pathological features of humans. Here we present a compendium of cell types from the cynomolgus monkey Macaca fascicularis (denoted as ‘Monkey Atlas’) using both single-cell chromatin accessibility (scATAC-seq) and RNA sequencing (scRNA-seq) data at the organism-wide level. The integrated cell map enables in-depth dissection and comparison of molecular dynamics, cell-type composition and cellular heterogeneity across multiple tissues and organs. Using single-cell transcriptomic data, we inferred pseudotime cell trajectories and cell-cell communications to uncover key molecular signatures underlying their cellular processes. Furthermore, we identified various cell-specific cis-regulatory elements and constructed organ-specific gene regulatory networks at the single-cell level. Finally, we performed a comparative analysis of single-cell landscapes among mouse, cynomolgus monkey and human, and we showed that cynomolgus monkey has significantly higher degree of cell-type similarity to human than mouse. Taken together, our study provides a valuable resource for NHP cell biology.
The foot drawing method: Reliability of measuring foot length and outward rotation in children with clubfoot.
Authors: Manousaki Evgenia , Andriesse Hanneke , Hägglund Gunnar , Ström Axel , Esbjörnsson Anna-Clara
Published: February 2022

Background: The Ponseti method is the gold standard for clubfoot treatment. However, relapse and residual gait deviations are common, and follow-up until 7 years of age is recommended. We evaluated the reliability of the foot drawing method, a new instrument for the follow-up of clubfoot. The method uses drawings of the foot in the neutral position and external rotation to measure foot length and outward rotation.Methods: Nineteen children aged 2.5–7 years who were treated with the Ponseti method for congenital clubfoot were included. Two raters made the drawings twice (D1 and D2). Each rater measured foot length, foot rotation, and foot–tibial rotation independently (D1). Later, the raters repeated the measurements (D2). Interrater reliability was assessed using the D1 from each rater. Intrarater reliability was assessed using the measurements from each rater’s D1 and D2. Bland–Altman plots were used to visualize the limits of agreement (LoA). The mean, 95% confidence interval, and one standard deviation of the differences in all measurements were calculated.Results: The mean differences between and within raters were: foot length <1 mm, foot rotation <1°, and foot–tibia rotation <2°, which indicated no systematic differences. The LoA for foot length were: 4.5 mm and 5.9 mm between raters for D1, –4.8 mm and 5.9 mm for rater 1 (D1–D2), and –5.1 mm and 5 mm for rater 2 (D1–D2). The LoA for foot rotation: were –12° and 10.6° between raters (D1), –8.4° and 6.6° for rater 1 (D1–D2), and –14° and 14.1° for rater 2 (D1–D2). The LoA for foot–tibia rotation were: –17.8° and 14.3° between raters (D1), –12° and 12.2° for rater 1 (D1–D2), and –12.7° and 13.6° for rater 2 (D1– D2).Conclusions: The absence of systematic differences between and within raters, and LoA observed indicate that the foot drawing method is applicable in clinical practice and research. However, the results of the foot and foot–tibia rotation analyses imply that caution is needed when interpreting changes in foot rotation in feet with higher degrees of rotation.
Not waiting for the death knell. A pilot study to examine supplementation and survivorship in a declining population of Tasmanian eastern quoll (Dasyurus viverrinus).
Authors: Hamer Rowena P , Robinson Natasha , Brewster Rob , Barlow Molly , Guinane Morrigan , Humphrey Morgan , Mifsud Adrian , Kutt Alex S.
Published: February 2022

Tasmanian populations of the eastern quoll Dasyurus viverrinus, which represent the last wild stronghold of this species after its extirpation from the Australian mainland, have experienced declines of more than 50% over the past three decades. In this pilot study, we investigate the feasibility of supplementing wild populations with captive-bred individuals to attempt to reverse observed declines. Our results are encouraging, in that we recorded high initial survival and low initial dispersal of captive-bred individuals relative to previous release attempts in mainland Australia. Further work is ongoing to determine long-term survival of released individuals and the genetic and population-level impacts on local populations. Our preliminary results support the use of population supplementation as an effective conservation action, which allows for early intervention to address species declines while simultaneously testing hypotheses about their underlying causes.
Molecular xenomonitoring as a complement to human antigen seroprevalence for lymphatic filariasis surveillance in Samoa
Authors: McPherson Brady , Mayfield Helen J. , McLure Angus , Gass Katherine , Naseri Take , Thomsen Robert , Williams Steven A. , Pilotte Nils , Kearns Therese , Graves Patricia M. , Lau Colleen L.
Published: February 2022

Molecular xenomonitoring (MX), the detection of filarial DNA in mosquitoes using molecular methods (PCR), is a potentially useful surveillance strategy for lymphatic filariasis (LF) elimination programs. Delay in filarial antigen (Ag) clearance post-treatment limits the usefulness of human surveys as an early indicator of the effectiveness of mass drug administration (MDA), and MX may be more sensitive in this setting. We compared prevalence of infected mosquitoes pre- and post-MDA (2018 and 2019) in Samoa, and investigated associations between presence of PCR-positive mosquitoes and Ag-positive humans. We observed a statistically significant decline in mosquito infection prevalence post-MDA, but no change in human Ag prevalence during this time. Presence of PCR-positive pools of ‘all species’ was most sensitive (78.6%) for detecting villages with Ag-positive humans, while Ae. polynesiensis provided the highest positive predictive value (81.8%). Our study provides promising evidence for MX as a complement to human surveys in post-MDA surveillance.
Effects of a New Filling Technique on the Mechanical Properties of ABS Specimens Manufactured by Fused Deposition Modeling
Authors: Hussam Heba , Abdelrhman Yasser , Soliman Mohamed Emad S. , Hassab-Allah Ibrahim M.
Published: February 2022

No one can deny the widespread of 3D printing in many different fields. This paper aims to improve the mechanical properties of parts printed by fused deposition modeling (FDM) technique. Acrylonitrile butadiene styrene (ABS) specimens are printed with custom printing parameters, these parameters give a tensile strength that is 86% of the injection molded ABS strength, and give one of the best results recorded for 100% infill printed ABS tensile specimens. Furthermore, a post filling technique has been studied, specimens are printed with inner voids and different densities using slicing software. Void shape is precisely selected to conform to the filling process. High-strength low-cost thermoset resin is injected through specimens to fill these voids. A tensile test has been performed after full curing of the resin and a morphology analysis is done. By this technique strength to printed weight ratio is improved by 151% and the cost is reduced by 51%.
The design of novel intelligent paradigms for future prediction smoking model with saturated occurrence rate
Authors: Nisar Kottakkaran Sooppy , Shoaib Muhammad , Zubair Ghania , Raja Muhammad Asif Zahoor , Morsy Ahmed
Published: February 2022

The approach of artificial neural network backpropagation with Levenberg Marquardt algorithm (LMA) and Bayesian Regularization algorithm (BRA) is used to analyze the smoking model in this study. We start by looking at a delayed smoking model wherein potential smokers be supposed to meet the logistic equation. As in manner of Delayed Differential Equations (DDEs), we analyze the dynamic characteristics of the developed framework and provide criteria regarding asymptotic stability of the system in steady condition. The model's Hopf bifurcation study is also addressed. The Adam numerical approach is used to build the reference dataset in Mathematica. The numerical and graphical results to the smoking problem is then interpreted using this dataset in MATLAB. The validity of applied techniques is validated using regression plots, MSE curves, and error histogram.
Impact of COVID19 pandemic on the incidence of health-care associated Clostridioides difficile infection
Authors: Merchante Nicolás , Chico Pablo , Márquez-Saavedra Esther , Riera Gerónima , Herrero Rocío , González-de-la-Aleja Pilar , Aller Ana I. , Rodríguez Juan Carlos , Rodríguez-Fernández Miguel , Ramos José Manuel , Trigo-Rodríguez Marta , Merino Esperanza
Published: February 2022

Objective: To investigate the impact of COVID19 pandemic on the incidence of health-care associated Clostridioides difficile infection (HA-CDI).Methods: Retrospective study conducted in the Hospital Universitario de Valme (HUV) and the Hospital General Universitario de Alicante (HGUA) in Spain between January 2019 and February 2021. The study period was divided into non-COVID19 period (2019 and months from 2020-2021 with ≤ 30 hospitalized COVID19 patients) and COVID19 period (months from 2020-2021 with > 30 COVID19 patients). HA-CDI incidence rates (IR) were calculated as the number of new CDI cases per 10.000 occupied bed-days (OBD) and antimicrobial consumption by means of the defined daily dose (DDD) per 1000 OBD. Results: During the COVID19 period, HA-CDI IR in the HUV was 2.6 per 10.000 OBD, which was lower than what was observed during the non-COVID19 period (4.1 per 10.000 OBD; p=0.1). In the HGUA, HA-CDI IR during COVID19 period was 3.9 per 10.000 OBD, which was not significantly different to the IR observed during the non-COVID19 period (3.7 per 10.000 OBD; p=0.8). There was a slight increase in the total antibiotic consumption during COVID19 period in both hospitals, with significant increases of certain high-risk antibiotics as cephalosporins. Conclusions: HA-CDI incidence has not increased during the COVID19 pandemic in two tertiary centers in Spain, in spite of a slightly higher antibiotic consumption during the COVID19 period in both hospitals. These findings suggest that, in the presence of strict infection control measures, hospital antibiotic consumption might have a lower impact than expected on HA-CDI.
OsWDRP3, a WD-40 repeat protein interacts with OsBAK1 to control leaf angle by modulating BR signaling
Authors: Zhang Lei , Xi Di , Wang Zi-Ying , Long Chen-Jie
Published: February 2022

Leaf angle is an essential component of plant architecture. Brassinosteroids (BRs) plays important roles in regulating leaf angle. WD-40 repeat proteins (WDRPs) act as versatile scaffolds for protein–protein interactions and participate in plant growth and development. To date, the functions of OsWDRPs have been largely unknown. Here, we found that OsWDRP3 regulates leaf angle through the BR pathway in rice. qRT–PCR and GUS reporter assays revealed that OsWDRP3 was expressed in a variety of tissues, especially leaves. OsWDRP3 predominantly resides in the cytoplasm and aggregates near the cell membrane. OsWDRP3-RNAi plants exhibited less sensitivity to BR than the wild type. Using bimolecular fluorescence complementation assays and Co-IP, we determined that OsWDRP3 interacts physically with OsBAK1. More importantly, an in vitro cell-free degradation assay showed that OsWDRP3 participates in the protein degradation of OsBAK1. We also found that the degradation of OsBAK1 was delayed in OsWDRP3 RNAi plants. In conclusion, our data suggest that OsWDRP3 affects BR signaling by regulating the concentration of OsBAK1 in the cytoplasm and thus regulating the leaf angle in rice.
Detection of anti-SARS-CoV-2 S1 RBD-specific antibodies prior to and during the pandemic in 2011-2021 and Covid-19 observational study in 2019-2021
Authors: Gumanova Nadezhda , Gorshkov Alexander U. , Bogdanova Natalya L. , Korolev Andrew I.
Published: February 2022

BackgroundLongitudinal surveys to continually monitor the seroprevalence around the globe are required to support the prevention and control efforts for assessment of the levels of endemic stability in certain countries and regions. We investigated seroprevalence of anti-SARS-CoV-2-S1 receptor-binding domain (RBD)–specific antibodies in the samples of participants recruited for various cardiovascular studies unrelated to exposure to the virus in 2011-2021. A cohort study recruited in 2019-2021 was used to evaluate the vaccination and anti-IgG-SARS-CoV-2–S1 RBD-positive statuses to assess the resistance and severity of Covid-19. Materials and MethodsThe present observational study included subjects 18 years of age and older randomly selected from various cohorts previously recruited from 2011 to 2021 from the city of Moscow and Moscow Region for a total of 565 serum samples including recent participants (N = 310); recruited in 2019-2021. The phone survey of the participants of this cohort was conducted in October, 2021. Anti-SARS-CoV-2 S1 RBD-specific antibodies were assayed in the serum samples (N = 565). At endpoint (October 30, 2021), participants of the 2019-2021 cohort (N = 310) were interviewed over phone using a questionnaire that included 5 questions as follows: 1) did the participant experience a respiratory disorder at any time before or after the enrolment in the study; 2) the date of the disorder; 3) severity of the disorder, including asymptomatic, mild, medium (fever and cough), or severe (hospitalization); 4) was the participant vaccinated and the date of vaccination; and 5) brand of a vaccine. ResultsThe data of the present study indicated that a small percentage (3-6%) of SARS-CoV-2-S1 RBD-specific antibodies was detected in participants recruited in 2011-2019. The percentage of SARS-CoV-2-S1 RBD-specific antibodies was increased to 16.5% in 2020 and to 46% in 2021. The vaccination rate of 238 respondents of this cohort was 58% from August, 2020 to October, 2021. If this rate is added to the rate of not vaccinated SARS-CoV-2-S1 RBD-positive subjects (11%), collective immunity was able to reach 69%. The data indicated that 12% of respondents were hospitalized. No cases of hospitalization were reported in vaccinated respondents. The morbidity rate in the subgroup of anti-SARS-CoV-2-S1 RBD-positive respondents was 5.4-fold higher than that in the subgroup of vaccinated respondents (OR = 5.4; CI: 1.4 -19.8; P = 0.01).ConclusionDetected small percentage of SARS-CoV-2-S1 RBD-specific antibodies in participants recruited in 2011-2019 indicated possible spreading of coronaviruses during the pre-pandemic period. Collective immunity in Moscow and Moscow region was able to reach 69% from August, 2020 to October, 2021. Obtained results demonstrated that vaccination protects against COVID-19 and related hospitalization
Fish skin microbiota under healthy and diseased conditions
Authors: Al-Ashhab Ashraf , Alexander-Shani Rivka , Avrahami Yosef , Erlich Roberto , Strem Rosa Ines , Meshner Shiri , Shanital Noam , Sharon Galit
Published: February 2022

Background: The welfare of farmed fish is influenced by numerous environmental and management factors. Fish skin is an important site for immunity and a major route by which infections are acquired. The objective of this study was to characterize bacterial composition variability on skin of healthy, diseased and recovered Gilthead Seabream (Sparus aurata) and Barramundi (Lates calcarifer). S. aurata, which are highly sensitive to gram-negative bacteria, were challenged with Vibrio harveyi. In addition, and to provide a wider range of infections, both fish species (S. aurata and L. calcarifer ) were infected with gram-positive Streptococcus iniae, to compare the response of the highly sensitive L. calcarifer to that of the more resistant S. aurata. All experiments also compared microbial communities found on skin of fish reared in UV (a general practice used in aquaculture) and non-UV treated water tanks. Results: Skin swab samples were taken from different areas of the fish (lateral lines, abdomen and gills) prior to controlled infection, and 24, 48 and 72 hours, 5 days, one week and 1 month post-infection. Fish skin microbial communities were determined using Illumina iSeq100 16S rDNA for bacterial sequencing. The results showed that naturally present bacterial composition is similar on all sampled fish skin sites prior to infection, but the controlled infections (T1 24 h post infection) altered the bacterial communities found on fish skin. Moreover, when the naturally occurring skin microbiome did not quickly recover, fish mortality was common following T1 (24 h post infection). We further confirmed the differences in bacterial communities found on skin and in the water of fish reared in non-UV and UV treated water under healthy and diseased conditions. Conclusions: Our experimental findings shed light on the fish skin microbiome in relation to fish survival (in diseased and healthy conditions). The results can be harnessed to provide management tools for commercial fish farmers; predicting and preventing fish diseases can increase fish health and welfare, and enhance commercial fish yields.
Genomic analyses identify significant genes and processes in adrenocortical carcinoma cells with overexpressed Ptch1
Authors: Zhang Min , Guo Hongmei , Gu Hanming , Liu James
Published: February 2022

Adrenocortical carcinoma is a rare malignancy that mainly comes from family diseases. However, the mechanism and treatment of this cancer are still unclear today. Here, our objective is to determine the significant genes and signaling by analyzing the RNA-seq data from the Ptch1 overexpression cancer cells. The KEGG and GO analyses showed the Calcium signaling pathway and Pathogenic Escherichia coli infection were the key signaling pathways in Ptch1-overexpressed cancer cells. Moreover, we further identified the ten interactive molecules including ALB, STAT3, FOS, NRXN1, SNAP25, SYP, FYN, SPP1, THY1, GRIN2A. Our study may provide insights into the mechanism of Ptch1 regulating adrenocortical carcinoma.
The asymmetric effect of technology shocks on CO2 emissions: A panel analysis of BRICS economies
Authors: Chen Jingjing , Yang Fuwei , Liu Yicen , Usman Ahmed
Published: February 2022

Technological innovation positively contributes to economic development in BRICS countries; their environmental consequences cannot be ignored. Thus, it is imperious to explore the impact of technological shocks on environmental quality. We used ARDL and NARDL models to draw empirical consensus on the data set from 1990 to 2019 for BRICS economies. The results of ARDL model reveal that technological shocks positively affect carbon emissions in the long-run and short-run. The findings of NARDL model reveal that positive shocks in technology positively affect carbon emissions in the long-run and short-run, implying that an increase in technological development triggers an increase in carbon emissions. However, the negative shocks in technology have a negative impact on carbon emissions in the long-run, inferring that a reduction in technological development leads to a decrease in carbon emissions. The negative shock in technology has no significant impact on carbon emissions in the short-run. The findings emphasize the importance of environmental-friendly technology to achieving sustainable development goals.
Preharvest Applications of Chitosan, Salicylic Acid, and Calcium Chloride Have a Synergistic Effect on Quality and Storability of Date Palm Fruit (Phoenix dactylifera L.)
Authors: Ahmed Zienab F.R. , Kaur Navjot , Maqsood Sajid , Schmeda-Hirschmann Guillermo
Published: February 2022

The ‘Khenizi’ date palm is one of the most recognized date palm cultivars. It is commonly consumed at the Bisr, Rutab, and Tamr stages of ripening; however, the fruit has a short shelf/storage life at this stage of maturity even with refrigeration. Preharvest application of a natural elicitor chitosan (Ch) has been reported to have positive influences on quality and shelf life of many fruits; however, synergetic effects of Chand other natural elicitors have not been investigated. Therefore, this study aimed to investigate the synergistic effect of preharvest spray treatments with Ch 1% in combination with calcium chloride (Ca) 3% and salicylic acid (SA) 2 mm on ‘Khenizi’ date fruit quality and storage life. Fruit quality parameters, including physical and physiochemical characteristics, phytochemical content, and bioactive properties, were determined at harvest time and during cold storage at 2 °C for 60 days for 2 months. Our results revealed that a combination of these elicitors had significantly influenced the fruit quality during storage compared with control. For instance, Ch+SA and Ch+Ca+SA treatments improved total phenolic content (TPC), and the antioxidant activity at harvest and at specific times during the postharvest storage period. Furthermore, Ch+SA+Ca treatment significantly delayed senescence in treated fruits during cold storage for 45 days as compared with other treatments and the control. In addition, Ch+Ca-treated fruits had the lowest weight loss after 45 days of cold storage. Ch+SA treatment had the lowest microbial counts as compared with other treatments, including the control. The significance of this study is that it provides evidence that a combination of these elicitors has the potential to improve fruit quality at harvest, as well as during postharvest storage Future studies should be directed to fine tune the concentrations and combinations that may have commercial applications.
PERFIL DE ELEMENTOS INORGÂNICOS EM AMOSTRAS DE MEL DO ESTADO DO MARANHÃO COMO UM POTENCIAL BIOINDICADOR DE ORIGEM GEOGRÁFICA
Authors: Leal Sonaly , Sousa Eliane , Silvério Gilmar , Lima Paulo
Published: February 2022

PROFILE OF INORGANIC ELEMENTS IN HONEY SAMPLES FROM THE MARANHÃO STATE AS A BIOINDICATOR OF GEOGRAPHICAL ORIGIN. Honey is a substance that contains a variety of macro and micro minerals present in the range between 0.02-1.03%. The main objective of this study was to determine the concentration of elements inorganic in 15 honey samples collected in various regions of Maranhão (Northeast Brazil), using highly sensitive analytical techniques, such as inductively coupled plasma optical emission spectrometry (ICP-OES), in addition to applying multivariate statistical tools, such as Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) in the treatment of data. The method presented detection limits between 0.4 to 2.8 mg kg-1. Fifteen samples and 19 metals were analyzed, and two of these samples had high levels of lead, exceeding the limits allowed by Brazilian legislation. Thus, it can be concluded that the presence of potentially toxic metals in honey is an indication that the production areas may be contaminated by different external sources. The chemometric analysis of the data by PCA and HCA allowed to classify honey in two main groups: honey produced in urban areas and honey produced in rural areas with PCA explaining 73% of the data variance with the sum of the first 3 components.
Factores asociados al consumo de drogas en estudiantes de Artes
Authors: Pavón León Patricia , Salas García Betzaida , De San Jorge-Cárdenas Xóchitl , Cruz Juárez Alma de los Ángeles
Published: February 2022

Introducción: Hay preocupación en todo el mundo por el incremento sostenido del consumo de drogas legales e ilegales entre jóvenes, particularmente entre estudiantes universitarios. En el caso de los estudiantes de Artes, el uso y abuso de drogas suele asociarse tradicionalmente con la creación artística. Sin embargo, existe poca evidencia científica que permita conocer las causas de este problema. Este artículo se propone analizar el consumo de drogas legales e ilegales en estudiantes del área académica de artes de una universidad pública mexicana y los factores psicosociales a los que están asociados.
Método: El diseño del estudio fue cuantitativo, transversal y analítico. La fuente de información fue la base de datos derivada del Cuestionario para el Consumo de Drogas en Estudiantes Universitarios (CODEU-2) empleado en el Segundo diagnóstico de percepción, riesgo y consumo de drogas en estudiantes universitarios, realizado en una universidad pública del estado de Veracruz, México. Este cuestionario fue aplicado en línea en la plataforma Lime Survey a los estudiantes de todos los periodos/semestres. Para identificar las diferencias entre variables, se utilizó la prueba exacta de Fisher y ji al cuadrado. Se consideró un nivel de significancia de 0.05. Además, se realizó un análisis de correspondencia múltiple para caracterizar a los estudiantes que consumen drogas legales e ilegales.
Resultados: El análisis del consumo de drogas ilegales en los últimos doce meses, mostró que 30.7 % de los estudiantes de Artes había consumido mariguana, 9.4 % drogas médicas sin prescripción, 6.8 % alucinógenos, 4.2 % cocaína y 3.6 % metanfetaminas. Respecto del consumo de drogas legales, el test AUDIT mostró que 62.21 % presentó consumo de bajo riesgo, 20.35 % consumo de riesgo moderado, 2.91 % de alto riesgo y 2.32 % de muy alto riesgo. En cuanto al consumo problemático de mariguana, 41.84 % mostró consumo de bajo riesgo, 12.27 % de riesgo moderado y 5.10 % de alto riesgo. En el análisis de correspondencias múltiples se identificaron cuatro grupos para los estudiantes que consumieron drogas legales. En el consumo de drogas ilegales se conformaron tres grupos.
Discusión: El consumo de drogas en los estudiantes de Artes es preocupante. Se recomienda desarrollar más y mejores estrategias preventivas dirigidas a jóvenes caracterizados por la vocación y la necesidad de ser creativos.
Flood frequency analysis and inundation mapping for lower Narmada basin, India
Authors: Mangukiya Nikunj K. , Mehta Darshan J. , Jariwala Raj
Published: February 2022

Floods are one of the world's most destructive natural disasters, taking more lives and causing more infrastructural damage than any other natural phenomenon. Floods have a significant economic, social, and environmental impact in developing countries like India. As a result, it is essential to address this natural disaster to mitigate its effects. The lower Narmada basin has experienced numerous floods, including severe flooding in 1970, 1973, 1984, 1990, 1994, and 2013. The objective of the present study is to use flood frequency analysis to anticipate peak floods and prepare flood inundation maps for the lower Narmada River reach. The flood frequency analysis was carried out using Gumbel's and Log-Pearson Type III Distribution methods. The hydrodynamic simulation was performed using HEC-RAS v6.0 to prepare flood inundation maps for predicted flood peaks. The result shows that the Log-Pearson Type-III distribution method gives good results for the lower return period while Gumbel's method gives good results for the higher return period. The hydrodynamic model results indicate that as the return period increases, the area of the high-risk zone increases while the area of the low-risk zone remains almost constant. The present study concludes that the existing embankment system on the banks of the Narmada River is not sufficient for significant floods. The developed maps will be helpful to government authorities and individual stakeholders to decide the flood mitigation measures.
Effects of community-based water management decisions at catchment scale, an interdisciplinary approach: the case of the Great Ruaha River Catchment, Tanzania
Authors: Richards Nathalie , Gutierrez-Arellano Claudia
Published: February 2022

Water User Associations are community-based institutions that cover segments of rivers and are responsible for water management decisions. These are the result of institutional blueprints designed by the international community, widely adopted around the world. However, the implementation gaps between these generic institutional designs and the working on the ground are vast and require site-specific information to support water management decisions at the local scale. We used a hydrological modelling approach to assess how community-based decisions can maximize their outcomes and improve overall availability of water resources in the Great Ruaha River Catchment in Tanzania, a catchment that is under severe drought pressures and is of the utmost ecological, social, and political relevance at the national scale. We provide information to support decisions on when and where to focus conservation and management strategies by identifying the seasonal and spatial variability of water availability in the catchment. Our methods have the potential to be used in other catchments around the world. This study shows the importance of assessing the hydrological processes affecting the geographies of community-based institutions to identify priority areas of action.
Pobreza multidimensional femenina brasileña en 2015
Authors: Batista Ravena de Carvalho Reis , De Oliveira Sibele Vasconcelos
Published: February 2022

Estudios desarrollados por las ciencias sociales vienen dedicándose al análisis del proceso de feminización de la pobreza explorando condicionantes de las diferentes fuentes de privación a las cuales las mujeres sonsometidas. Esta investigación pretende analizar la pobreza multidimensional femenina en el Brasil en 2015 calculando este nivel de pobreza a través del método Alkire-Foster. Los resultados mostraron que el 13,63% de las mujeres brasileñas fue considerada multidimensionalmente pobre, y que las mayores privaciones sufridas por ellas son el acceso a la educación formal y a las buenas condiciones de trabajo doméstico.
Polymeric Nanoparticles for the Treatment of Prostate Cancer-
Technological Prospecting and Critical Analysis
Authors: Droppa-Almeida Daniela , de Oliveira Clauberto Rodrigues , Padilha Francine Ferreira , de Souza Roberto Rodrigues , de Albuquerque-Júnior Ricardo Luiz Cavalcanti
Published: February 2022

Background:

Polymeric nanoparticles have a wide diversity, and due to their toxicity and
biodegradability, they have been widely used in the health area. Its use allows stability of some compounds,
targeted delivery, and increased half-life, in this context, making some treatment proposals
more effective. Prostate cancer, in turn, is among the types of cancer with the highest mortality, and the
lack of effective treatment causes several strategies to meet this need.

Objective:

The objective of this work was to verify patents that use polymeric nanoparticles for the
treatment of prostate cancer.

Methods:

For that, specific keywords to direct the search were applied in Patent Scope. After obtaining
the patents, one was selected for the development of critical analysis in relation to its chemistry and biology.

Results:

A total of five patents were found and, of these, an invention that used PCL-PLGA-PEGCOOH
polymeric nanoparticles with two natural compounds, resveratrol and celastrol, providing an
alternative method to traditional monotherapies.

Conclusion:

The prospective analysis serves to direct us in relation to the technologies currently used
in certain fields. Based on several cases of cancer and specifically the countless cases of prostate cancer,
five recent patents were found using polymeric nanoparticles. However, only one brought a different
aspect of all the treatments used lately. It brought an invention containing two natural compounds
being carried with polymeric nanoparticles with promising results.
Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and
Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines
Authors: Rizk Sandra , Idriss Maya , Younes Maria , Abou Najem Sonia , Hodroj Mohammad Hassan , Fakhoury Rajaa
Published: February 2022

Background:

Breast Cancer is one of the most commonly diagnosed cancers worldwide and a major cause of death among women. Although chemotherapeutic agents remain the keystones in cancer therapy, significant side effects have failed to provide a safe and tolerable treatment for cancer patients. Dietary antioxidant vitamins were extensively investigated over the past years and their relevance in cancer chemotherapy remains to be elucidated.

Objective:

In the current study, we aimed to investigate the anti-proliferative and apoptotic effects of combining γ-tocotrienol, a member of the vitamin E family, with the chemotherapeutic drug etoposide in MCF-7 and MDA-MB-231 breast cancer cell lines.

Methods:

The antiproliferative effect of etoposide combined with γ-tocotrienol was measured using MTS viability reagent. The pro-apoptotic effect was elucidated through Cell Death ELISA and dual Annexin V/PI staining followed by flow cytometric analysis.

Results:

Our results showed that etoposide significantly decreased the cell growth of both cell lines, with MDA-MB-231 cells being more sensitive to etoposide treatment than MCF-7. Moreover, sim-ultaneous treatment of both breast cancer cell lines with low doses of γ-tocotrienol and etoposide induced a synergistic antiproliferative effect (CI<1). Furthermore, the combination therapy signifi-cantly increased the percentage of total apoptotic cells in the MDA-MB-231 cell line and the degree of DNA fragmentation as compared to treatment with either compound alone.

Conclusion:

In conclusion, our results provide evidence for the profound anti-tumorigenic effect of combined etoposide and γ-tocotrienol in the breast cancer cell lines.
Opus Dei e a santificação do trabalho uma versão católica da ética protestante?
Authors: Vilaça Helena , Elias Rúben
Published: February 2022

This article analyses the ideal of sanctification of the work of Opus Dei, a Catholic organization with a more conservative nature and target of media coverage and general common sense perceptions. Through mobilization ofthe Weberian perspective of the Protestant work ethic, it is possible to find similarities between (intramundane) asceticism ofOpus Dei and the Puritan work ethic, mainly of a Calvinist slant. To identify common traits, empirical research was carried out in the Metropolitan Areas of Portoand Lisbon, based on interviews with members of Opus Dei. The analysis of the results allowed us to obtain a deeper knowledge not only about the conception of work and lifestyles, but also about the dynamics of this institution.
Qual é o teu legado?: a renovação digital do Museu do Coa como instrumento de aproximação às suas comunidades
Authors: Fernandes António Batarda , Pereira Pedro Daniel , Aubry Thierry , Santos André Tomás
Published: February 2022

The Coa Museum, open in 2010, is the entryway to the Coa Valley Archaeological Park. The visit to the rock art sites at the Coa is an authentic, irreplaceable experience that does not need ‘artifices’ to be enjoyed beyond a captivating guide delivering scientifically approved knowledge to visitors on the art and its natural and cultural context. Thus, the Museum’s exhibition programme was originally thought of as a complement to the visit to the Park that could summarize the scientific information collected in the last decades in the Coa Valley as well as presenting the most relevant rock imagery of a territory that extends for about 200 km2 . A decade after inauguration, taking advantage of the augmented and virtual reality devices that have now been made available, time had come to update the exhibit, making the visit even more captivating. Therefore, this chapter intends to present, discuss, and muse on the digital renovation recently implemented at the Coa Museum.
Da documentação à divulgação : contributos para a acessibilidade digital da coleção de instrumentos musicais do Museu Nacional da Música
Authors: Furtado Cláudia
Published: February 2022

Evolving from an introductory Massive Open Online Course (MOOC), the Specialization Pilot Course “Digital Skills for Museum Professionals of the 21st Century”, within the scope of the Mu.SA - Museum Sector Alliance Project (2016-2020) integrated a practical component of an internship, or work-based learning. In the case of this contribution, this materialized at the Museu Nacional da Música, in Lisbon, developing competences within the scope of the functional profile of the Digital Collections Curator. During the internship, a detailed diagnosis of the contents of the inventory sheets of the museum’s instrumental collection was carried out, to contribute to the qualification and promotion of the accessibility of the information available, in public access, through the Matriznet platform, which is presented. This contribution also addresses a series of questions about the need for technological evolution within museological institutions and the role that specialized training plays in the development of competences in museum professionals.
Pemberdayaan Anggota Kelompok Pkk Desa Sukomulyo Sebagai Upaya Membentuk Jiwa Wirausaha dan Meningkatkan Kesejahteraan
Authors:   Universitas Muhammadiyah Malang, Indratmi Dian Indratmi , Zalizar Lili ,   Universitas Muhammadiyah Malang, Sujono Sujono ,   Universitas Muhammadiyah Malang
Published: February 2022

Program pemberdayaan masyarakat telah dilakukan kepada anggota kelompok PKK desa Sukomulyo Kecamatan Pujon Kabupaten Malang oleh tim pelaksana Program Pengembangan Desa Mitra (PPDM), dari Universitas Muhammadiyah Malang. Program bertujuan untuk membentuk wirausaha baru di bidang olahan susu yang dapat meningkatkan kesejahteraan masyarakat Desa Sukomulyo. Metode pelaksanaan meliputi ceramah dan diskusi, demonstrasi dan praktek langsung/pelatihan serta pendampingan. Anggota kelompok PKK mendapatkan pelatihan pembuatan berbagai olahan susu meliputi susu pasteurisasi, susu jelly, stick susu dan kerupuk susu; serta pendampingan dalam manajemen usaha dan pemasaran produk. Hasil kegiatan menunjukkan program pemberdayaan anggota PKK telah sukses melahirkan wirausahawan baru di bidang olahan susu sebesar 31,25 % dari yang mengikuti kegiatan pelatihan. Program juga terbukti mampu meningkatkan pendapatan dan kesejahteraan keluarga peternak, yang ditunjukkan dengan keberhasilan pemasaran produk hasil pelatihan seperti susu jelly, stick susu, dan kerupuk susu. Ketiga produk tersebut merupakan makanan yang bergizi, sehingga program ini juga telah mendukung peningkatan kesehatan masyarakat.
Canadian Intelligence for the Dangerous Decades
Authors: Fyffe Greg
Published: February 2022

On November 23, 2021, Mr. Greg Fyffe presented Canadian Intelligence for the Dangerous Decades at the 2021 CASIS West Coast Security Conference. The presentation was followed by a question and answer period with questions from the audience and CASIS Vancouver executives. The key points of discussion included an overview of Mr. Fyffe’s most recent report on the structure of the Canadian intelligence system and points of improvement for both the Canadian intelligence system as well as the national security strategy.
Police Ethics
Authors: Lewis Richard
Published: February 2022

On November 25, 2021, Chief Cst. Richard Lewis from Cleveland Police (United Kingdom) presented Police Ethics at the 2021 CASIS West Coast Security Conference. The presentation was followed by a question and answer period. The key points discussed were police ethics in the United Kingdom (UK), the role of the National Police Ethics Committee, and public involvement to maintain a trusting relationship between the public and law enforcement.
Introduction to Re@ct: Social Change Art Technology
Authors: DeLappe Joseph , Leuzzi Laura
Published: February 2022

This is the Introduction to the special issue Re@ct: Social Change Art Technology, co-edited by Sarah Cook, Joseph DeLappe, and Laura Leuzzi. The issue gathers essays, artists' statements, and experimental writing projects from selected participants in a three-day symposium held in Dundee, Scotland in 2019, in partnership with the NEoN Digital Arts Festival.
The Shadow Database: Activism, Art, and Aspiration within Urban Regeneration
Authors: Keene Tom
Published: February 2022

This visual essay presents Database (E)state, which is an artist and activist-led PhD research project that explores the role of relational databases in processes of urban regeneration. The essay addresses the proposed demolition of Cressingham Gardens Estate by Lambeth Borough Council, in South West London, in the UK. By depicting the problems associated with accessing, comprehending, and creating a resident-controlled ‘Shadow Database’ of Lambeth’s databases systems, the essay points to the material, ethical, and political implications of database technologies in residents' lives. This articulation draws from art practice, philosophical theories derived from Gilbert Simondon and Michel Foucault, and also histories of database technologies. The act of creating the Shadow Database, therefore, combines theory, art, and activism as a means to make human and technical components of Lambeth’s databases more accountable to residents.
The Ghost Newspaper: Fake Journalism in the Mexican Drug War
Authors: Velazco Fernando Martín
Published: February 2022

During the 2010s, Tamaulipas, a border state in northern Mexico, became a “silenced zone” for journalism as a result of the Mexican Drug War. In 2016, during an international theatre festival in the port of Tampico, the Stultifera Navis Institutom collective intervened at the headquarters of what used to be one of the most important journals in the city. The building, located in downtown Tampico, had been abandoned for thirty-three years. For three days, we brought the newspaper “back to life,” using only fake news.
This essay recovers the experience of this multidisciplinary site-specific intervention by casting a critical look at its theoretical foundation in Jacques Derrida’s concept of “Hauntology” and Georges Didi-Huberman’s method of “Anachronism.” Engaging deontological debates within media practice and the “virtuality” concept in literature, it analyzes the use of fiction as an act of discursive rebellion. Finally, “spectrality” and Aby Warburg’s notion of “images in history” are problematized with a decolonial perspective, concluding with a reflection on the theatrical character of historical resurgences through an analysis of Shakespeare’s Hamlet.
Scientific Literacy: To days Necessity
Authors: Mishra Dr. Pratima
Published: February 2022

This era of the 21st century has been termed as the digital age because in this era the changes taking place in the living conditions of human beings have been such that the digital society has been born. The pace of developmental change in this digital society is so fast that keeping pace with it is a challenging task. In this digital world scientific literacy is very important factor.. In this research we found that urban students are leading in the comparison of rural students and girls are moving faster than boys. It is required to improve scientific literacy in rural area and hurdle is lack of supply of electricity and unavailability of resources.
Prevalence and Factors Associated with Hydatidiform Mole among Patients with Missed Abortion
Authors: Mutalib Dr. Trifa Yousif
Published: February 2022

A large number of studies have reported different prevalence rates for hydatidiform mole in different regions, making it difficult to determine the exact prevalence of this condition. There has been no previous study that has determined the prevalence of HM and the risk factors associated with it among patients who have had an missed abortion and were evacuated from the Medical Center and private hospitals in Erbil. Between August 2015 and October 2021, a total of 180 patients who had undergone amissed abortion were enrolled.. Participation in this study was voluntary and included one hundred and eighty patients with missed abortions who were scheduled for uterine evacuation. The prevalence of HM was 12.8 percent in the overall population. The vast majority of patients with HM (27.5 percent) were under the age of twenty-one years. Risk factors such as parity, contraceptive use, previous abortion, and blood group were not found to have a statistically significant association with the outcome. Prevalence of HM among patients with missed abortion was high (12.8 percent), with age between 15-20 years being the only significant risk factor associated with the presence of HM among those who had anmissed abortion. As a result, we recommend that evacuated products of conception be submitted for histopathological analysis in order to reduce the number of missed opportunities.
Technological Revolution in Computer Aided Education
Authors: Sivaranjani Ms. S.
Published: February 2022

Abstract: Computer-assisted education is a critical component in increasing the efficacy and quality of the training system. Computer education is a part of the school and college curricula since it is essential for today's child or adult. The intention of this article is to emphasise the role of computers in education especially for people who are suffering from Autism Disorder.
Sumário
Authors: Mazzioni Sady , Fossá Juliano Luiz , Baú Dal Magro Cristian , Ghisi Feuerschütte Simone
Published: February 2022

Sumário
Considerações sobre o sublime e a poética do movimento
Authors: Brazón Mariela
Published: February 2022

O objetivo deste artigo é examinar os pontos de contato entre a arte cinética e a poética do sublime, explorando diálogos com outras categorias estéticas e relações com expressões artísticas em que o sublime é manifestamente tratado. Para o desenvolvimento das ideias, usamos como referências as análises de Julian Bell, Barnett Neuman e Robert Rosemblum. No que diz respeito à arte do movimento, o ponto de partida foi a revisão histórico-crítica de Frank Popper, com destaque para suas colocações sobre a estética do sublime. Foram identificadas pelo menos três abordagens para o problema: as relações com a natureza, a imersão na luz e na cor, e o espírito de sacralidade presente em momentos de criação e revelação.

Palavras chaves

Sublime, Arte cinética, Arte do movimento
Augmented Reality dan Pehitungan Rendemen pada Produksi Kayu Profil Menggunakan Mesin Router
Authors: Hermawan Hermawan , Wihartiko Fajar Delli , Abdillah Yugo Ahmad
Published: February 2022

Salah satu produk olahan kayu yang masih banyak diminati pasar adalah wood profile moulding. Bentuk profil yang tidak mengikuti ruang dasar geometris tertentu dapat dihadirkan melalui Augmented Reality. Pendugaan rendemen produksi kayu profil menjadi kurang akurat dengan bentuknya yang tidak beraturan. Augmented Reality memberikan bentuk nyata dari profil kayu yang akan dibentuk dari pilihan bit router. Augmented Reality dibangun menggunakan penanda (marker) yang diberikan dalam bentuk desain bit router 2D. Aplikasi yang dibuat dengan platform Android bahkan memudahkan pengguna untuk memilih jenis dan spesifikasi bit router, sesuai dengan bentuk profil yang diinginkan. Telah diuji untuk jenis Carbide Cove Router dengan tujuh bit router. Aplikasi dilengkapi dengan perkiraan jumlah profil, volume, hasil produksi, dan limbah kayu yang dihasilkan dari bahan baku kayu yang akan dikerjakan. Percobaan dilakukan pada bahan baku papan berukuran 30x200x2000 mm, menghasilkan jumlah profil cekung yang bervariasi antara 3-5 buah, sesuai dengan ukuran mata bor terluar. Hasil produksi bervariasi dari 42,95 hingga 74,44%. Peningkatan rendemen tersebut sejalan dengan jumlah bilah kayu profil yang diproduksi.