bluuebunny/crossref_metadata_2025 huggingface dataset:
Anger in Consumer Reviews: Unhelpful but Persuasive?
Authors:   University of South Florida, Yin Dezhi , Bond Samuel ,   Georgia Institute of Technology, Zhang Han ,   Georgia Institute of Technology
Published: September 2021

A common assumption in prior research and practice is that more helpful online reviews will exert a greater impact on consumer attitudes and purchase decisions. We suggest that this assumption may not hold for reviews expressing anger. Building on the theory of emotions as social information (EASI), we propose that although expressions of anger in a negative review tend to decrease reader perceptions of review helpfulness, the same expressions tend to increase the negative influence of the review on reader attitudes and decisions. Results from a series of laboratory experiments provide support for our claims. Our findings challenge the widely accepted assumption that more “helpful” reviews are ultimately more persuasive and extend the current understanding of the interpersonal effects of emotion in online communication. Our findings also suggest implications for review platforms, retailers, marketers, and manufacturers faced with the task of managing consumer reviews.
When All Products Are Digital: Complexity and Intangible Value in the Ecosystem of Digitizing Firms
Authors:   University of Georgia, Rahmati Pouya , Tafti Ali ,   University of Illinois at Chicago, Westland J. Christopher ,   University of Illinois at Chicago, Hidalgo Cesar ,   University of Toulouse
Published: September 2021

During the last four decades, digital technologies have disrupted many industries. Car control systems have gone from mechanical to digital. Telephones have changed from sound boxes to portable computers. But have the firms that digitized their products and services become more valuable than firms that didn’t? Here we introduce the construct of digital proximity, which considers the interdependent activities of firms linked in an economic network. We then explore how the digitization of products and services affects a company’s Tobin’s q—the ratio of market value over assets—a measure of the intangible value of a firm. Our panel regression methods and robustness tests suggest the positive influence of a firm’s digital proximity on its Tobin’s q. This implies that firms able to come closer to the digital sector have increased their intangible value compared to those that have failed to do so. These findings contribute a new way of measuring digitization and its impact on firm performance that is complementary to traditional measures of information technology (IT) intensity.
Capability Development through Just-in-Time Access to Knowledge in Document Repositories: A Longitudinal Examination of Technical Problem Solving
Authors:   University of Minnesota, Subramani Mani , Wagle Mihir ,   Microsoft, Ray Gautam ,   University of Minnesota, Gupta Alok ,   University of Minnesota
Published: September 2021

With knowledge and expertise increasingly being recognized as important, firms have made significant investments in document repositories as part of their knowledge management initiatives. Document repositories are intended to enhance the ability to access codified knowledge and help improve task performance through knowledge reuse. However, it is not clear what effects they have on how knowledge workers perform their tasks. Using longitudinal data on repository accesses and calls to technical support by field technicians in an engineering firm, we examine how just-in-time access to codified knowledge affects patterns of help-seeking from technical support. We find evidence that greater accessing of codified knowledge reduces calls for help to technical support. The type of codified knowledge accessed from the repository affects field technicians’ calling behavior. Accessing general knowledge reduces calls to support for low-complexity problems, while accessing procedural knowledge reduces calls related to high-complexity problems. Further, accessing procedural knowledge is significantly associated with promotion, suggesting that the use of document repositories can help individuals build firm-specific human capital. Building on the insights of cognitive load theory, this study suggests that making information available just in time through document repositories reduces the cognitive load involved for task performance and enables learning. This work contributes to a greater understanding of the value of knowledge management systems and suggests that, beyond the efficiencies gained from knowledge reuse, just-in-time access to knowledge repositories builds problem solving capabilities and contributes to human capital development.
When Digital Technologies Enable and Threaten Occupational Identity: The Delicate Balancing Act of Data Scientists
Authors: Vaast Emmanuelle ,   McGill University, Pinsonneault Alain ,   McGill University
Published: September 2021

Occupations are increasingly embedded with and affected by digital technologies. These technologies both enable and threaten occupational identity and create two important tensions: they make the persistence of an occupation possible while also potentially rendering it obsolete, and they magnify both the similarity and distinctiveness of occupations with regard to other occupations. Based on the critical case study of an online community dedicated to data science, we investigate longitudinally how data scientists address the two tensions of occupational identity associated with digital technologies and reach transient syntheses in terms of “optimal distinctiveness” and “persistent extinction.” We propose that identity work associated with digital technologies follows a composite life-cycle and dialectical process. We explain that people constantly need to adjust and redefine their occupational identity, i.e., how they define who they are and what they do. We contribute to scholarship on digital technologies and identity work by illuminating how people deal in an ongoing manner with digital technologies that simultaneously enable and threaten their occupational identity.
AI on Drugs: Can Artificial Intelligence Accelerate Drug Development? Evidence from a Large-Scale Examination of Bio-Pharma Firms
Authors:   University of Connecticut, Lou Bowen , Wu Lynn ,   University of Pennsylvania
Published: September 2021

Advances in artificial intelligence (AI) could potentially reduce the complexities and costs in drug discovery. We conceptualize an AI innovation capability that gauges a firm’s ability to develop, manage, and utilize AI resources for innovation. Using patents and job postings to measure AI innovation capability, we find that it can affect a firm’s discovery of new drug-target pairs for preclinical studies. The effect is particularly pronounced for developing new drugs whose mechanism of impact on a disease is known and for drugs at the medium level of chemical novelty. However, AI is less helpful in developing drugs when there is no existing therapy. AI is also less helpful for drugs that are either entirely novel or those that are incremental “follow-on” drugs. Examining AI skills, a key component of AI innovation capability, we find that the main effect of AI innovation capability comes from employees possessing the combination of AI skills and domain expertise in drug discovery as opposed to employees possessing AI skills only. Having the combination is key because developing and improving AI tools is an iterative process requiring synthesizing inputs from both AI and domain experts during both the development and the operational stages of the tool. Taken together, our study sheds light on both the advantages and the limitations of using AI in drug discovery and how to effectively manage AI resources for drug development.
George Steiner y el ocaso de las Humanidades
Authors:   Universidad de Piura, Sánchez-Costa Enrique
Published: September 2021

El poeta indio Tagore denunciaba en 1917: «El hombre moral, el hombre íntegro, está cediendo cada vez más espacio […] al hombre comercial, el hombre limitado a un solo fin. Este proceso […] causa el desequilibrio moral del hombre y oscurece su costado más humano bajo la sombra de una organización sin alma» (Nussbaum, 2010, p. 7). Cien años después, las palabras de Tagore son más actuales y acuciantes que nunca. El técnico, el científico y el empresario son hoy los señores del mercado (lo que, para muchos, es tanto como decir: los señores del mundo). La educación ha sido obligada a discurrir por el cauce estrecho de las «competencias», que la reducen a lo utilitario, lo lucrativo, lo pragmático. La cantidad se impone a la calidad; el hacer, al ser.
Virosomes as drug delivery system: An updated review
Authors: Mohd Muaz Mughees  , Mughees Ahmad Ansari  , Afifa Mughees  , Faisal Farooque  , Mohd Wasi
Published: September 2021

Amid the era of development in all sphere of Biotechnology, Biochemistry and Pharmacology, it would not be an exaggeration to say that we have a myriad of molecules available to us in labs with promising results against many diseases. The limitation lies in the fact that some molecules are toxic when they act on organs other than their targets. Yet others cannot reach their targets in the desired concentration, be it due to easy degradation in the gut or high first-pass metabolism or very short half-life, etc. Thus, to overcome this, we have an alternate drug delivery system, namely Virosomes. The purpose of this review is to understand the drug delivery aspect of the virosomes, its type, structure, method of preparation, mechanism of action, administration routes and the application in the medical field. Virosomes are the regenerated viral envelope having a central empty space that can act as the vehicles for drug delivery. The central empty space can be filled with the desired bioactive molecule. Virosomes are most commonly prepared by using the reconstituted viral envelope of the Influenza virus, but other virus such as Sendai or HVJ, Hepatitis B Virus, HIV, New castle Disease Virus etc., can also be used for the preparation of virosomes. Virosomes has a great potential as the drug delivery system for almost all types of the drugs, and this encourages the researchers and therapeutic industries to enhance their pharmacological profiles, clinical result and stability.
“Gingival Crevicular Fluid Levels of Interleukin-35 in Periodontal Health, Chronic Periodontitis & the Effect of Scaling & Root Planning on Interleukin-35 Levels in Chronic Periodontitis – A Randomized Controlled Clinical Study”
Authors: Varghese Dr. Ammu , Mysore Babu Dr. Harsha , R Naik Dr. Archana , A M Dr. Savita , Nanaiah Kukkera Dr. Pallavi
Published: September 2021

Background & Objectives: Interleukin-35 (IL-35) is a newly identified anti-inflammatory cytokine generated by T regulatory cells. They are most effective at high inflammation sites and are a potent activator of T regulatory cells. Hence this study aimed to assess gingival crevicular fluid levels of IL-35 in healthy subjects and chronic periodontitis patients and to compare the levels of IL-35, before and after scaling and root planing in chronic periodontitis patients. Methods: Forty subjects were selected and categorised into 3 groups. Group 1: Periodontally healthy individuals, Group 2A: Chronic periodontitis patients and Group 2B: Group 2A patients who were evaluated 6 weeks after scaling and root planing. Gingival bleeding index, probing pocket depth and clinical attachment level were recorded. Gingival crevicular fluid samples were collected and stored at -800 C till they were subjected to analysis by Enzyme Linked Immunosorbent Assay (ELISA). Results: On intergroup comparison, the difference in mean IL-35 levels and clinical parameters were highly statistically significant between Group 1 and Group 2A while between Group 1 and Group 2B were not significant. On comparing Group 2A and Group 2B, the mean differences were highly statistically significant P (<0.001). Significant reductions in all parameters were noted in Group 2B. Conclusion: Significant reduction of IL-35 levels in chronic periodontitis patients, 6-8 weeks after scaling and root planing and their presence in periodontally healthy subjects suggest the role of IL-35 in controlling the inflammation and their protective role in maintaining periodontal health. Key message: IL-35 has an effective role in controlling the inflammation and in maintaining periodontal health. IL-35 can be considered as a promising prognostic biomarker in periodontal diseases.
21. yüzyıl becerileri bağlamında öğrenci, öğretmen ve eğitim ortamları
Authors: ÇİFTCİ Serkan , YAYLA Ahmet , SAĞLAM Abdulkadir
Published: September 2021

20. yüzyılda başlayan ve son yüzyılda devam eden yenilikler yaşamın her alanına etki etmektedir. Dünyadaki değişim ve yeniliklere uyum sağlayabilmek, yön verebilmek için bireylerin hayatlarının her aşamasında öğrenmeyi sürdürmeleri gerekmektedir. Dünyadaki bu hızlı değişim ve gelişim, her gün beraberinde yeni bilgiler, yeni teknolojiler ve yeni yaklaşım tarzları ortaya çıkarmaktadır. Yaşam boyu öğrenmenin sürdürülebilir hale gelmesi için en önemli etmen, eğitim sisteminin 21.yüzyıl becerilerine sahip bireyler yetiştiren bir metodu hayata geçirmesi olacaktır. Burada eğitim sisteminden, sistemi meydana getiren temel öğelerden öğrenciler, öğretmenler ve eğitim ortamının oluşturduğu yapı kastedilmektedir. Eğitim sistemlerinde öğrencilerin ihtiyaç duyacağı eğitsel donanımlar, eğitim sisteminin amaçlarına ulaşması için gereklidir. Bu amaçlar doğrultusunda 21. yy. becerilerine sahip öğrencilerin ve eğitim sisteminin çıktılarının gerekli özelliklerle donatılmış olarak işgücü piyasasına veya yüksek öğretime dâhil olması beklenir. Eğitimciler ve işgücü piyasası uzmanları, çocukların 21. yy. becerilerini kazanmaları gerektiğini vurgulamakta ve bu beceriler olmadan onların küresel eğitim ve işgücü piyasasına katılmada başarısız olabileceklerini ifade etmektedirler. Bu çalışmada 21.yüzyıl becerilerinin eğitim sistemindeki yerinin incelenmesi amaçlanmıştır. Bunu yaparken 21. yüzyıl becerilerinin ve alt boyutlarının neler olduğu, bu beceriler kapsamında öğrencilerin, öğretmenlerin ve eğitim ortamlarının sahip olması gereken özelliklerin neler olması gerektiği üzerinde durulmuştur.
İl Özel İdarelerinde Kamu Hizmeti Motivasyonu: Burdur İli Örneği
Authors: ÖZTÜRK Hasret
Published: September 2021

Bu çalışmanın amacı Burdur İl Özel İdaresinde görev yapan personelin kamu hizmeti motivasyonu algılarını belirlemektir. Betimsel tarama modelinde desenlenen bu çalışmanın evrenini Burdur İl Özel İdaresinde görev yapan 112 memur ve 226 işçi oluşturmaktadır. Örneklem büyüklüğü 83’ü memur ve 110’u işçi olmak üzere 193 olarak belirlenmiştir. Çalışmanın verileri Kamu Hizmeti Motivasyonu Ölçeği kullanılarak toplanmıştır. Yapılan analizler sonucunda, Burdur İl Özel İdaresinde görev yapan personelin kamu hizmeti motivasyonu algıları istihdam türü, cinsiyet, çalışma süresi, eğitim düzeyi değişkenlerine göre farklılık gösterirken, yaş değişkenine göre değişiklik göstermediği sonucuna varılmıştır. Araştırmanın bulgularına dayalı olarak, iş zenginleştirme ve iş rotasyonu gibi insan kaynakları uygulamaları önerilmiştir.
Çalışma Sermayesi Etkinliği Ölçümünde Endeks Yöntemi: Borsa İstanbul Yiyecek-İçecek, Konaklama ve Havayolu Ulaştırma İşletmelerinde Bir Uygulama
Authors: GÜNAY Fatih
Published: September 2021

Çalışma sermayesi kararları işletmelerin likidite, kredibilite ve satışların arttırılmasında etkilidir. Çalışma sermayesi yönetim etkinliği kârlılığı ve firma değerini arttırabildiği gibi işletme başarısızlığına ve iflasa sebep olabilir. Endeks yöntemi satışlardaki değişimlerle yönetici kararlarının sonucu olan çalışma sermayesindeki değişimlerin ilişkilendirildiği etkinlik ölçüm yöntemidir. Finansman kararlarını dikkate almaması endeks yönteminin zayıf yönü olmakla birlikte diğer yöntemlere kıyasla belirli üstünlükleri bulunmaktadır. Bu çalışmada endeks yöntemi açıklanarak, Borsa İstanbul’da işlem gören yiyecek içecek, konaklama ve havayolu ulaştırma işletmelerinde çalışma sermayesi yönetim etkinliğinin ölçülmesi amaçlanmıştır. Borsa İstanbul yiyecek içecek ve konaklama sektöründe listelenen 9 işletme ve havayolu ulaştırma sektöründen 2 işletmenin 2009-2019 dönemi yıllık gözlemlerinde etkinlik değerleri hesaplanmıştır. Endeks yöntemiyle gerçekleştirilen sınırlı literatüre katkı sağlayan çalışmada elde edilen bulgular, yiyecek içecek ve konaklama işletmeleri etkinliğinin dalgalı, havayolu işletmeleri etkinliklerinin ise dengeli olduğunu göstermektedir. Ayrıca yiyecek içecek ve konaklama işletmelerinde çalışma sermayesi yönetim etkinliğinin havayolu ulaştırma işletmelerine kıyasla daha zayıf diğer ifadeyle satış gelirlerini arttırmada dönen varlık kullanım etkinliğinin yetersiz olduğu tespit edilmiştir. Turizmi ve sektörü etkileyen gelişmelerin olduğu dönemlerde satışlardaki daralmaya karşı yiyecek içecek ve konaklama işletmelerinin çalışma sermayesi kararlarında aynı yön ve düzeyde tepkiler vermediği sonucuna ulaşılmıştır.
Uluslararası Halkla İlişkiler Faaliyetlerinde Devlet Başkanı Eşleri: Mihriban Aliyeva Örneği
Authors: MAMMADOV Musa , TURHAN Miraç Savaş
Published: September 2021

Devlet, organizasyon çalışmalarının ve uluslararası halkla ilişkiler alanının kesişim kümesinde yer alan inceleme nesnelerinden biridir. Devlet başkanlarının eşleri ve politikadaki varlıkları da geniş sayılabilecek bir yazına sahiptir. Ancak başkan eşlerinin devletlerin uluslararası halkla ilişkiler faaliyetlerindeki rollerini konu edinen çalışmaların halen katkıya açık bir alanı oluşturduğu gözlemlenmektedir. Bu çalışmada, devlet başkanı eşlerinin uluslararası arenada devletlerinin halkla ilişkiler faaliyetlerinde oynadıkları rollerin kapsamının anlaşılabilmesi amaçlanmaktadır. Bu bağlamda, Azerbaycan Cumhurbaşkanı İlham Aliyev’in eşi Mihriban Aliyeva’yı inceleme konusu eden bir nitel durum/vaka (örnek olay) analizi tasarlanmış ve Mihriban Aliyeva’nın, ikincil kaynaklardan elde edilen ve uluslararası halkla ilişkiler konusu kapsamında değerlendirilebilecek, faaliyetleri yazında yaygın olarak üzerinde durulan halkla ilişkiler uygulamaları çerçevesinde içerik analizi ile incelenerek değerlendirilmiştir. Ulaşılan bulgular, Aliyeva’nın farklı halkla ilişkiler uygulamaları kapsamında değerlendirilebilecek çeşitli faaliyetlerini göstermektedir.
Gebelerde HBsAg, Anti-HCV Seroprevalansı ve Hepatit B Bağışıklığının Değerlendirilmesi: Tanımlayıcı Çalışma
Authors: ÖNER Sedef Zeliha , KALIPCI İrem , OKUR Asuman
Published: September 2021

Amaç: Çalışmada, kadın hastalıkları ve doğum polikliniğinde takipli gebelerde hepatit B yüzey antijeni (HBsAg), anti-HCV seroprevalansı ve Hepatit B Virus’e karşı bağışıklık durumunun değerlendirilmesi amaçlanmıştır.

Materyal ve Metot: Tanımlayıcı tipteki bu çalışmada kadın hastalıkları ve doğum polikliniğinde Kasım 2018 - Kasım 2019 tarihleri arasında muayene olan gebelerin serum örneklerinde HBsAg, anti-HBs ve anti-HCV tetkik sonuçları değerlendirildi. Örnekler HBsAg, anti-HBs ve anti-HCV elektrokemiluminesans immünoassay (ECLIA) yöntemi (Cobas e 601, Roche Diagnostics, Mannheim, Germany) kullanılarak çalışıldı.

Bulgular: Kadın hastalıkları ve doğum polikliniğine başvuran 1361 gebe değerlendirilmeye alındı. Gebeler 17-49 yaş aralığına sahipti. Yaş ortalaması 27.7±4.8 yıl olarak tespit edildi. Gebelerin 21’inde (%1.5) HBsAg, 2’sinde (%0.15) anti- HCV, 708’inde (%52) anti-HBs pozitif olarak değerlendirildi. HBsAg ve anti-HCV seropozitifliği oranları ile yaş grupları arasında anlamlı bir farklılık bulunmadı (p>0,05). Anti-HBs seropozitifliği oranı yaş grupları arasında farklı dağılmıştır (p=0,001). Yirmi yaş ve altındaki gebelerin anti-HBs seropozitifliği oranları ile 20 yaş üstü gebeler anti-HBs seropozitifliği oranları arasındaki fark istatistiksel olarak anlamlı bulundu (p=0,015).

Sonuç: Anti-HCV seropozitifliği ülkemizde son yıllarda yapılan çalışma sonuçlarına göre daha düşük ve HBsAg seropozitifliği ise benzer bulunmuştur. Bu çalışmanın yapıldığı popülasyonun yarıdan fazlası anti-HBs seropozitifliğine sahipti. Çalışmada 20 yaş ve altında olan gebelerde HBsAg seropozitifliği görülmemesinin ve anti-HBs seropozitiflik oranın diğer yaş gruplarına göre yüksek olmasının ulusal aşılama programının etkinliğinden kaynaklandığı düşüncesindeyiz.
İzmir’de Toplumda Kanser Tarama Testleri Farkındalığı ve Bireylerin Kanser Tarama Testlerine Katılımını Etkileyen Faktörler
Authors: BABAOĞLU Asya , BÜYÜKÖZMEN Eren , CAN Fatma
Published: September 2021

Kanserler tüm dünyada önde gelen mortalite ve morbidite nedenleri arasındadır. Türkiye’de 2008’den beri “Ulusal Kanser Tarama Programı” yürütülmektedir. Ancak yapılan çalışmalar tarama programına katılım oranlarının yeterli seviyede olmadığını göstermektedir. Bu çalışmanın amacı, bireylerin Ulusal Kanser Tarama Programı kapsamındaki testler konusundaki farkındalıklarını ve bu testleri yaptırma durumlarını etkileyen değişkenleri tespit etmektir.

Kesitsel tipteki çalışmada 449 kişiye yüz yüze anket uygulanmıştır. Meme, serviks ve kolorektal kanser tarama testlerini yaptırma oranları, duyma oranları ile karşılaştırıldığında oldukça düşüktü. Üç tarama programında da en önemli katılmama nedenleri bilgi eksikliği olarak tespit edildi. Sağlık personeli, medya ve diğer sağlık okuryazarlığını artırıcı çalışmalarla toplumda bilgi eksikliğinin giderilmesi ve hatalı bilgilerin yerine doğru bilgilerin getirilmesi, tarama testlerine katılımı artıracak çalışmalar olarak önerilmektedir.
The need for basic medical science knowledge in clinical setting: perspective of early clinicians
Authors: KAYA Oktay
Published: September 2021

Aim: The aim of the study was to evaluate the opinions of research assistants working in clinical departments about basic medical sciences education and their tendency in career choices.

Methods: The study was conducted on 110 research assistants working in the internal and surgical medical sciences. The data were obtained by using a questionnaire developed by the researcher and based on volunteering.

Results: When the study group was asked about the field of basic medical sciences they used most during their professional lives, physiology ranked first with 36.8% (n=32). 73.2% of the participants responded to the proposition that I need basic medical science knowdelge in my specialty. 43.1% of the participants agreed with the statement that I absolutely did not want to do specialty training in the field of basic medical sciences.

Conclusion: It was thought that basic medical sciences curriculum should be structured according to the needs of clinical sciences. The positive opinion on basic medical education does not reflect on career choice.
Diz Osteoartriti Hastalarında Tanı ve Kılavuzlar Işığında Güncel Tedavi
Authors: YILMAZ DEMİRİZ Serap , SARIKAYA Selda
Published: September 2021

Osteoartrit (OA) eklem sertliği ve ağrı ile birlikte; işlevsellikte azalma ve ardından yaşam kalitesinde bozulmaya yol açan; genellikle yaşla ilişkili, inflamatuar kaynaklı, dejeneratif bir eklem hastalığıdır ve dünya çapında pek çok insanı etkilemektedir. Diz eklemi primer olarak osteoartritin en sık görüldüğü eklemlerden biri olup, diz OA yaşlılardaki ağrı ve fiziksel engelliliğin ana nedenleri arasında yer alır. Diz OA tanısı her ne kadar klinik bulgular ve fizik muayene ile yapılabilse de, eklem tutulumunun derecesinin yanı sıra diyagnostik doğrulama için radyolojik değerlendirme yapılır. OA’de tedavi planlanması hastanın eğitimi, semptomların kontrol altına alınması, hastalık progresyonunun sınırlandırılması, fonksiyonların korunması ve iyileştirilmesi üzerine kurulmalıdır. Bu hedeflere ulaşabilmek için diz OA tedavisi, nonfarmakolojik, farmakolojik ve gerektiğinde cerrahi yöntemleri içermelidir. OA hastaları için literatürde yeni tedavi önerileri sunan çalışma raporlarının yayınlanmasına devam edilmekte ve bu hastaların tedavi seçeneklerini içeren yönergeler gün geçtikçe güncellenmektedir. Bu derlemenin amacı diz OA hakkındaki genel bilgilerin değerlendirilmesi ve bu hastalıktaki güncel tedavi rehberlerinin kanıt düzeyleri eşliğinde sunulmasıdır.
Tuberosklerozda intrakranyal lezyonların Difüzyon Tensör Görüntüleme bulguları
Authors: ÇEŞME Dilek Hacer
Published: September 2021

Amaç: Tuberoskleroz’lu (TSC) olgularda kortikal/subkortikal yerleşimli tuberler ile beyaz cevher lezyonlarının (BCL) normal görünen karşı serebral hemisfer (NGKSH) ve korpus kallozum genu (KKG) ile KK splenium (KKS), ADC (görünür difüzyon katsayısı) ve FA (fraksiyonel anizotropi) değerleri açısından farklılık gösterip göstermediğini ve aralarındaki korelasyonu araştırmayı amaçladık.
Gereç ve Yöntem: TSC’li 23 olgunun beyin MRG ve DTG (Difüzyon Tensör Görüntüleme) bulguları geriye dönük olarak değerlendirildi. Tuberler, BCL, NGKSH, KKG ve KKS’nin ADC ve FA değerleri ölçülerek karşılaştırıldı.
Bulgular: Tuber ve BCL’nin ADC değerleri, NGKSH, KKG ve KKS’a göre belirgin yüksek izlenirken, FA değerlerinde azalma saptandı (Herbiri için; p= 0.0001). Tuber ADC değerleri ile KKS FA değerleri arasında negatif korelasyon mevcuttu (p=0.003, r= -0.304). BCL’nin FA değerleri ile KKS ADC değerleri arasında negatif korelasyon saptandı (p=0.02, r= -0.395).
Sonuç: TSC’li olgularda ADC ve FA değerlerindeki değişiklikler hamartomatöz proliferasyona ve miyelin kılıf bozukluklarına bağlı yapısal değişikliklerle açıklanabilir. DTG, TSC’li olgularda beyin lezyonlarının oluşum mekanizmasını hücresel düzeyde daha iyi anlamamıza katkıda bulunacağı görüşündeyiz.
Familial Mediterranean Fever Present with Gastrointestinal Manifestations of Henoch Schonlein Purpura
Authors: BATTAL Fatih , GÜZEL Yusuf , KAYMAZ Nazan , KİRMİZİTAŞ Ezgi , KURTULUŞ Şenay
Published: September 2021

Henoch Schönlein Purpura is the most common small vessel vasculitis in childhood which is characterized with non-thrombocytopenic purpuric skin rash, arthritis, abdominal pain and renal disease. Palpable purpura usually occurs as the first clinical finding. However, gastrointestinal symptoms can rarely appear before the rash and may cause delays in diagnosis. Here, we present a case of Henoch Schönlein Purpura who underwent appendectomy with the diagnosis of acute abdomen and developed skin involvement in clinical follow-up. Another significant point of the case is having anamnesis of recurrent abdominal pain and the diagnosis of Familial Mediterranean Fever by genetic analysis after Henoch Schönlein Purpura attack.
ANALYSIS OF HEAT RELEASE RATE IN ENGINE ROOM FIRES OF 300 GT FERRY RO-RO PASSENGER BY USING WATER MIST SYSTEM AND CO2 SYSTEM
Authors: Setiawan Wira , Kotanjungan Distyan
Published: September 2021

Based on statistical data in recent years, there are still quite a number of ship accidents due to fires, including on passenger ships. The water mist system is a fire suppression system that allows it to be used in the engine room with the advantage that it can keep the heat production rate low during the extinguishing process and can be operated earlier than the CO2 system. The research is conducted by using fire dynamic simulator in the engine room of a 300 GT ferry ro-ro passenger to compare the heat release rate of fire without an extinguishing system, an existing CO2 system, and a water mist system. The result shows that the CO2 fire suppression system reduces the heat release rate more rapidly to the decay phase at 375 seconds while the water mist takes more than 900 seconds. However, the fully developed phase of the water mist suppression system occurs more quickly than CO2 because the sprinklers are activated shortly after a fire occurs. Unlike water mist, the CO2 system is activated at 60 seconds so that the pre-combustion, growth, flashover, and fully developed phases are at the same HRR and time as the natural one.
Migração Intra-Abdominal de Sistema Intrauterino Após Perfuração Uterina
Authors: Sousa Teresa Maria , Martins Helga
Published: September 2021

Mulher de 37 anos, 2 gesta, 2 para (G2P2), sem antecedentes de relevo, colocou um sistema intrauterino (SIU) em consulta de ginecologia, dois meses após o segundo parto, em 2017. Foi realizada uma ecografia ginecológica imediatamente após a sua colocação, que assegurou o correto posicionamento do SIU. [...]
Mapeamento georreferenciado do patrimônio material e imaterial localizado no município de Nova Iguaçu, Rio de Janeiro.
Authors: Reis Emanuela de Almeida Rangel
Published: September 2021

O presente trabalho integra-se à pesquisa “O estado da arte da aplicação de tecnologias digitais na documentação do patrimônio material imóvel no Brasil”, que investiga a aplicação de tecnologias da i
A CONSTRUCTIVIST ANALYSIS OF THE IMPACT OF INDIA’S DOMESTIC IDENTITIES ON ITS NEIGHBOURHOOD POLICIES TOWARDS SOUTH ASIA
Authors: RAFİQUE Shakaib
Published: September 2021

Domestic factors especially national identities of a Nation State influence its foreign policy by distinguishing that country’s perception of “self” from that of “others”. By employing the case study of India, this paper assesses the way India perceives its national identities and the resultant effects on its foreign policies towards South Asia. The paper assesses that in India, its peculiar political construct superimposed by British colonizers and multiple ethno-religious groups stacked together under a Hindutva-inspired political system serve as an aberration from the evolution of indexical “self” of different nationalities in that country. Accordingly, India’s national identity formation is premised on “exclusion” and it attempts to overcome this challenge through externalization of its internal problems towards neighbourhood.
The Impact of Mobile Health on Breast Cancer Patient’s Life and Treatment: A Systematic Review
Authors: Sohrabei Solmaz , Atashi Alireza
Published: September 2021

Introduction: Breast cancer rates have been increasing worldwide, particularly among young women, suggesting important interactions between genes and health behaviors. At the same time, mobile technology, including smartphones applications (apps), has emerged as a new tool for delivering healthcare and health-related services. In 2019, there were nearly 670 publicly available breast cancer apps designed to provide disease and treatment information, to manage disease, and raise overall awareness.Material and Methods: In order to conduct a review, the Medline, Scopus and PubMed databases were searched with the keywords "mobile health", "mobile health in electronics health", "breast cancer and electronic health"," mobile health and breast cancer"," mobile health and breast cancer qualify life" and their equivalent. Out of the 60 articles found, after the depth of the criteria Inclusion in the study, 16 articles remained, which were reviewed and given using PRISMA 2020 checklist. SPSS software v.22 was used for description analysis.Results: A total of 16 articles met the inclusion criteria and were included in this review. All studies have determined the positive impact of applications on cancer detection and clinical health outcomes. In addition, more than half of mobile applications have multiple functions, such as providing information, planning and education. Furthermore, most studies examining patient satisfaction and quality improvement have shown that users of healthcare applications are significantly more satisfied with life, leading to better quality.Conclusion: The evidence of the studies which are included in this systematic review is currently limited, but it suggests that the mobile apps might be an acceptable information source for women with breast cancer and lead to improved patient well-being.
Integration of Genomics Data and Electronic Health Records Toward Personalized Medicine: A Targeted Review
Authors: Najafi Ali , Emami Neda , Samad-Soltani Taha
Published: September 2021

Introduction: Integration of rapidly expanding high-throughput omics technologies and electronic health record (EHR) has created an unprecedented advantage in terms of acquiring routine healthcare data to accelerate genetic discovery. In this regard, EHR can also provide several important advantages to omics research if the integration challenges are well handled. The main purpose of the present study was to review available and published knowledge in the related literature and then to classify and discuss stakeholders’ requirements in this domain.Material and Methods: At first, a broad electronic search of all available literature in English was conducted on the topic through a search in the databases of Medline, Web of Science, Institute of Electrical and Electronics Engineers (IEEE), Scopus, and Cochrane. Then, stakeholders’ requirements were tabulated, and finally, a word cloud was generated and analyzed to achieve functional and non-functional cases.Results: A total of 81 articles were included in the given analysis. Integration requirements also consisted of nine functional cases including a uniform approach to the interpretation of genetic tests, standardized terminologies and ontologies, structured data entry as much as possible, an integrated online patient portal, multiple data source handling, machine-readable storing and reporting, research-oriented requirements, pharmacogenomics decision support capabilities, and phenotyping algorithms and knowledge base. Besides, there were three non-functional cases comprised of interoperability of multiple systems, ethical, legal, security factor, and big data computations.Conclusion: The main challenges in this way could also have semantic and technical themes. Therefore, system developers could guarantee the success of systems by overcoming the given challenges.
The Importance of Recording Self-Reported Information in the Management of COVID-19 Virus Variants: A Technology-Based Approach
Authors: Salmanizadeh Farzad , Ameri Arefeh
Published: September 2021

COVID-19 virus variants are rapidly spreading across the world. Successful tracing of contacts and early isolation after the onset of symptoms are vital, because, in this period, patients can infect other people having contact with them before isolation. One method for identifying, tracing, screening, and monitoring the potential patients can be self-reporting of information by these individuals. The present letter suggested importance of recording self-reported information in the management of COVID-19 virus variants using technology-based devices.
TRAVELLING HABITS OF PEOPLE WITH DISABILITIES
Authors:   University of Pécs, Faculty of Business and Economics, Department of Marketing and Tourism, Pécs, Hungary, GONDA Tibor
Published: September 2021

Accessible tourism is an under-researched area in Hungary. Based on the results of a questionnaire survey, the aim of the present study is to present several specific features of the travel demand of people with disabilities, the foremost focus being the examination of the most popular tourism products in the demand of people with disabilities. 268 Hungarians responded to the survey in online and face-to-face contexts. In addition to the Hungarian survey, the article also covers small-sample research results from four other countries (Germany, Italy, Spain and Croatia). The results show that members of the target group reject segregation solutions during their travels, and, as opposed to integration, clearly demand inclusion. Their travel frequency is above average of the entire population, with interests as diverse as those without disabilities. The issue of accessible tourism affects 10% of the European population, and thus, besides the significance of the issue from a social and societal point of view, this segment cannot be neglected in terms of its market value either. Understanding the expectations of stakeholders and their specific consumer habits is an essential requirement in the development of appropriate tourism supply and in ensuring equal access to services.
Innovation Ecosystem: Review of the Research Field
Authors:   Institute of Economics of the Ural branch of RAS, Akberdina V.V. , Vasilenko E.V. ,   Institute of Economics of the Ural branch of RAS
Published: September 2021

The article focuses on a relatively new concept of innovation ecosystem. The purpose of this article is to provide an analytical review of the Russian and international research field associated with this concept. The study relies on the methods of meaningful content analysis of publications. The article outlines the history of the concept’s emergence; six different approaches to its understanding and their evolution. Based on a wide range of sources, the analysis reveals the fundamental aspects of the concept directly related to the diversity of its applications. Demonstrating the differences between the concept of innovation ecosystem and other similar concepts (e. g. digital ecosystem, regional innovation ecosystem), we show the main feature of all ecosystems — the coevolution of its participants throughout their interaction. The factors that affect the development of innovation ecosystems are also identified. The final part of the article is devoted to the analysis of the interpretations of the concept ‘innovation ecosystem’ and to the conceptual ‘traps’ inherent in the operationalization of this concept. The concept ‘innovation ecosystem’ is now beginning to acquire practical significance marking the transition to a new paradigm in management; it is the starting point for a variety of approaches designed to solve specific practical problems.
Recent Issues in High-Level Perception
Authors: Helton Grace
Published: September 2021

Recently, several theorists have proposed that we can perceive a range of high-level features, including natural kind features (e.g., being a lemur), artifactual features (e.g., being a mandolin), and the emotional features of others (e.g., being surprised). I clarify the claim that we perceive high-level features and suggest one overlooked reason this claim matters: it would dramatically expand the range of actions perception-based theories of action might explain. I then describe the influential phenomenal contrast method of arguing for high-level perception and discuss some of the objections that have been raised against this strategy. Finally, I describe two emerging defenses of high-level perception, one of which appeals to a certain class of perceptual deficits and one of which appeals to adaptation effects. I sketch a challenge for the latter approach.
Process drivers, inter-model spread, and the path forward: A review of amplified Arctic warming
Authors: Taylor Patrick , Boeke Robyn , Boisvert Linette , Feldl Nicole , Henry Matthew , Huang Yiyi , Langen Peter , Liu Wei , Pithan Felix , Sejas Sergio , Tan Ivy
Published: September 2021

Arctic amplification (AA) is a coupled atmosphere-sea ice-ocean process. This understanding has evolved from the early concept of AA, as a consequence of snow-ice line progressions, through more than a century of research that has clarified the relevant processes and driving mechanisms of AA. The predictions made by early modeling studies, namely the fall/winter maximum, bottom-heavy structure, the prominence of surface albedo feedback, and the importance of stable stratification have withstood the scrutiny of multi-decadal observations and more complex models. Yet, the uncertainty in Arctic climate projections is larger than in any other region of the planet, making assessment of high-impact, near-term regional changes difficult or impossible. Reducing this large spread in Arctic climate projections requires a quantitative process understanding. This manuscript aims to build such understanding by synthesizing current knowledge of AA and to produce a set of recommendations to guide future research. It briefly reviews the history of AA science, summarizes observed Arctic changes, discusses modeling approaches and feedback diagnostics, and assesses the current understanding of the most relevant feedbacks to AA. These sections culminate in a conceptual model of the fundamental physical mechanisms causing AA and a collection of recommendations to accelerate progress towards reduced uncertainty in Arctic climate projections. Our conceptual model highlights the need to account for local feedback and remote process interactions, specifically the water vapor triple effect, within the context of the annual cycle to constrain projected AA. We recommend raising the priority of Arctic climate sensitivity research, improving the accuracy of Arctic surface energy budget observations, rethinking climate feedback definitions, coordinating new model experiments and intercomparisons, and pursuing the role of episodic variability in AA as a research focus area.
Differential contributions of inferior frontal gyrus subregions to sentence processing guided by intonation
Authors: van der Burght Constantijn L , Numssen Ole , Schlaak Benito , Goucha Tomás , Hartwigsen Gesa
Published: September 2021

Auditory sentence comprehension involves processing content (semantics), grammar (syntax), and intonation (prosody). The left inferior frontal gyrus (IFG) is involved in sentence comprehension guided by these different cues, with neuroimaging studies preferentially locating syntactic and semantic processing in separate IFG subregions. However, this regional specialisation has not been confirmed with a neurostimulation method. Consequently, the causal role of such a specialisation remains unclear. This study probed the role of the posterior IFG (pIFG) for syntactic processing and the anterior IFG (aIFG) for semantic processing with repetitive transcranial magnetic stimulation (rTMS) in a task that required the interpretation of the sentence’s prosodic realisation. Healthy participants performed a sentence completion task with syntactic and semantic decisions, while receiving 10 Hz rTMS over either left aIFG, pIFG, or vertex (control). Initial behavioural analyses showed an inhibitory effect on accuracy without task-specificity. However, electrical field simulations revealed differential effects for both subregions. In the aIFG, stronger stimulation led to slower semantic processing, with no effect of pIFG stimulation. In contrast, we found a facilitatory effect on syntactic processing in both aIFG and pIFG, where higher stimulation strength was related to faster responses. Our results provide first evidence for the functional relevance of left aIFG in semantic processing guided by intonation. The stimulation effect on syntactic responses emphasises the importance of the IFG for syntax processing, without supporting the hypothesis of a pIFG-specific involvement. Together, the results support the notion of functionally specialised IFG subregions for diverse but fundamental cues for language processing.
What you hear is what you see: Sounds alter the contents of visual perception
Authors: Williams Jamal Rodgers , Markov Yuri , Tiurina Natalia , Störmer Viola
Published: September 2021

Visual object recognition in the real world is not performed in isolation, but is instead dependent on contextual information such as the visual scene an object is found in. And our perceptual experience is not just visual: objects generate specific and unique sounds which can readily predict which objects are outside of our field of view. Here, we test whether and how naturalistic sounds influence visual object processing and demonstrate that auditory information both accelerates visual information processing and modulates the perceptual representation of visual objects. Specifically, using a visual discrimination task and a novel set of ambiguous object stimuli, we find that naturalistic sounds shift visual representations towards the object features that match the sound (Exp. 1a- 1b). In a series of control experiments, we replicate the original effect and show that these effects are not driven by decision- or response biases (Exp. 2a-2b) and are not due to the high-level semantic content of sounds generating explicit expectations (Exp.3). Instead, these sound-induced effects on visual perception appear to be driven by the continuous integration of multisensory inputs during perception itself. Together, our results demonstrate that visual processing is shaped by auditory context which provides independent supplemental information about the entities we encounter in the world.
Geology and sedimentary environment of the Surma Group of rocks, Bandarban anticline, Bandarban, Bangladesh
Authors: Haque Md. Masidul , Roy Mrinal Kanti
Published: September 2021

The study illustrates the effect of tectonics, climate, and relative sea-level change on the depositional process of the Miocene Bhuban and Boka Bil Formation of Bengal Basin. Outcrop sediments of five transverse sections exposed along the axial zone of Bandarban anticline were studied. Twelve lithofacies such as Gm, Gms, Sm, ST, Sp, Sr, Sl, Sf, Sll, Fw, Fl and Fm have been identified within the successions and grouped into (i) turbidite generated, (ii) outer fan distal lobe basin plain and (iii) tide-influenced facies association. The analyses reveal that the Bhuban Formation was turbidite- generated that deposited below the continental shelf-slope environment. The Lower Bhuban Member consists of gray to brownish-gray calcareous sandstone with shale deposited under the channelized lobe of submarine fan. The Middle Bhuban Member dominated by black shale-siltstone deposited in distal turbidite lobe due to change the flow regime. The Upper Bhuban Member consists of yellow to yellowish gray, coarse to medium-grained sandstone-siltstone with black shale that deposited under channelized to nonchannelized lobes of submarine fan. The increasing sedimentation during the formation of the Upper Bhuban Member can be caused by increased the intensity of the Asian Monsoon that carried huge sediment from the Himalaya. The Boka Bil Formation was deposited under estuary to tidal flat environment. The area was uplifted during and/or after subduction of the Indian Plate beneath the Burmese Plate. The monsoonal intensity enhances sedimentation that moved prograding delta towards the south. These processes shifted depositional environment from continental shelf-slope to marginal shallow marine during deposition of the Boka Bil Formation. The continental slope aligned east-west direction and sediments likely derived from the Himalaya and Trans-Himalaya in the present geographical setup during deposition of the sediments.
TEACHING SUMMARIZING AND PARAPHRASING SKILLS IN A FOREIGN LANGUAGE CLASSROOM
Authors:   Ph. D Associate Professor, VSU, Vanadzor, Armenia, Papoyan A.
Published: September 2021

Paraphrasing and summarizing are powerful skills that everyone should develop while learning a foreign language. These two tools are the main clues for integrating the sources into the papers. Paraphrasing and summarizing are very useful as they allow to convey other’s ideas in one’s speech without cluttering up the paragraphs with quotation marks. It is important to be able to summarize and paraphrase correctly to effectively integrate the research into the paper without any plagiarism. By paraphrasing and summarizing the writer shows a full understanding of the topic, identifies the most important information and explains it using his way of outlook. The article tries to highlight the main characteristic features of paraphrasing and summarizing skills, suggests some ways how to develop them and tries to find out the existing differences between them.