bluuebunny/crossref_metadata_2025 huggingface dataset:
Prefacio: Catálogo razonado de los murales y esculturas de las rotondas del Museo de La Plata
Authors: Lanteri Analía
Published: January 2025

The catalogue presented here is the result of research work carried out responsibly and appropriately by a team that joined the program of restoration, cataloging and digitalization of cultural heritage promoted by the direction of the La Plata Museum five years ago, providing it with theoretical and disciplinary quality. It consists of an Introduction by its editor (Marcela Andruchow), 12 chapters, bibliography (general and specific) and photographs of all the works studied.
Cacerías prehistóricas y el territorio en paisajes murales de Luis de Servi
Authors: Andruchow Marcela
Published: January 2025

This work studies the paintings that Luis de Servi made for the Museo de La Plata between 1886 and 1888. It begins with a brief biography of the artist and then analyzes and presents the interpretations of his works. de Servi painted several murals in the entrance rotunda of the Museo, eight of which are preserved: two large ones and six small ones. These are oil paintings on zinc sheet, canvas or cardboard, attached to the wall. The large paintings represent scenes from prehistoric life in Argentina, and the small ones represent various landscapes from all over the country. From a plastic arts perspective, these works are stylistically coherent with the Macchiaioli (“spot-makers”) and the Pleinairism. As for the meaning of their themes, references and models, the large murals illustrate scientific conjectures about prehistoric life held at the time, when the odest inhabitants of our continent live together with the extinct animals about 10,000 years ago. On the other hand, in addition to their decorative purpose, De Servi's small paintings take on the character of geographical documents or imaginary indicators of the national territory and may have been painted from photographs of the expeditions made by Francisco Moreno (founder and first director of the Museum). In this sense, it is worth considering that they were commissioned by the abovementioned director and that he played a decisive role in the commission and guidelines on themes, motifs and location of these works.
Nuevos territorios en los finales del Siglo XIX. Augusto Ballerini en el Museo de La Plata
Authors: Sánchez Pórfido María Elisabet , Nuñez Andrea Mónica
Published: January 2025

This work studies one of the works created by the artist Augusto Ballerini for the Museo de La Plata: the mural Selva misionera. It begins with a brief biography of the author and goes on to analyze and interpret his painting. Ballerini (1857-1902) was a multifaceted artist who worked as a teacher, illustrator, decorator, manager and visual artist. He executed several commissions in La Plata city for different government agencies, and he painted three large murals in the Museo de La Plata: Salvajes provocando fuego (1887), Vista de los Andes (1887) –both in the rotunda at the entrance to the Museum– and Selva misionera (n.d.), on the upper floor of this rotunda. Only the last of these murals is preserved today. Like many artists at a time when the matter of landscape was in full debate, and with the explicit intention of capturing different geographies of the country, Ballerini traveled through Patagonia, the Northwest, Mesopotamia, the Gran Chaco and the mountain regions in pursuit of the inclusion of national art within the iconography of the emerging Nation.
Francisco Vecchioli: multidisciplinario y peculiar
Authors: Sánchez Pórfido María Elisabet
Published: January 2025

Francisco Vecchioli (1892-1945) trained as a painter and illustrator in La Plata, France and Mallorca. He adopted naturalism and verismo with a certain eclectic quality, resulting in innovative atmospheric values ​​in his compositions. This can be seen in El ombú, a painting located in the first floor rotunda of the Museo de La Plata. His works refer to a city in full growth, whose transformations he would capture in natural and urban landscapes executed en plein air. Likewise, his representations refer to his trips to south and central Argentina, the pampas, and to European cities. Vecchioli´s works were included in exhibitions curated by prestigious critics and historians, he received numerous awards, was a member of artistic associations, taught at the Escuela Superior de Bellas Artes of the Universidad Nacional de La Plata, collaborated as a scientific illustrator at Museo de La Plata and in 1920 its director, Dr. Luis María Torres, invited him to paint the mural that is the object of this analysis (El Ombú).
Animal escondido. Obras de Maldonado en el Museo de La Plata
Authors: Ruvituso Federico
Published: January 2025

This work delves into the works that the animal sculptor Máximo Maldonado made for the Museo de la Plata in the 1940s. These are sculptural heads of animals native to Argentina made from reconstituted stone, located in the entrance hall of the Museum. These pieces summarize the characteristics that made Maldonado a renowned animalist due to the “humanizing” features that he knew how to sculpt in the eyes, brow and, above all, in the mouth of each of his creatures. The animals made by this artist are neither cold nor static scientific representations, but rather friendly, even humorous figures. This work begins with a brief review of Maldonado’s artistic career and then moves on to a plastic analysis of his sculptures and the interpretations of their exhibition within a Natural History museum.
Centenary Paper: Hacia una genética del intervalo: en torno a las series intermediales de Jorge Eduardo Eielson
Authors: PRIETO JULIO
Published: January 2025

Este ensayo pone en diálogo dos de las tendencias críticas más fecundas de las últimas décadas, la escuela francesa de la crítica genética y la escuela alemana de los estudios sobre intermedialidad, para formular un esbozo teórico sobre lo que podrían ser los principios operativos de una genética intermedial. Partiendo de la ‘genética generalizada’ de Marco de Biasi, planteo la necesidad de retomar el concepto de ‘traducción intersemiótica’ (Jakobson) para desarrollar una ‘genética de redes’ acorde con las específicas condiciones de la creación literaria y artística en la era digital, así como en la tradición moderna de los ‘desobramientos’ (Blanchot), que recorren el siglo XX, donde la categoría de ‘obra’ pierde relevancia ante las nociones de archivo, red o serie. Este modelo teórico se ilustra a partir de las series intermediales del poeta y artista plástico Jorge Eduardo Eielson, cuya polifacética producción, en cuanto caso paradigmático de ‘poesía expandida’ (Novalis), se presta idóneamente al análisis desde la perspectiva de una ‘genética del intervalo’ (Philippe Hamon) intermedial e intercultural.
Strategi Pemerintah dalam Meningkatkan Kualitas Pelayanan Publik di Kelurahan Karanganyar Kecamatan Astana Anyar Kota Bandung
Authors: Fajarwati Neri
Published: January 2025

In general, the apparatus provides services to the community according to the needs of the community itself. However, the facts on the ground are that government officials have not been able to carry out their duties and functions properly. In addition to the quality of the apparatus, this is also due to the fact that not all people can identify their own needs, so that people simply trust the apparatus in their area. The approach used in this study is a qualitative approach. The qualitative research method is a method used to study the state of a particular subject, based on the philosophy of postpositivism (Sugiyono, 2016). The data collection method in this study was based on literature studies, observations, and interviews. Public services carried out in the Karanganyar Village have been running quite well and smoothly. In its implementation, there were still a few obstacles, but this was resolved properly and quickly by the apparatus. Lack of assistance from the central government, such as facilities and infrastructure, such as filing cabinets, which are felt to be lacking and the lack of an integrated system to facilitate apparatus services to the community. As well as the need for education and training for apparatus considering the times and increasingly advanced technology in order to support the creation of quality services.
Analisis Kapasitas Kelembagaan Badan Perencanaan Pembangunan Daerah Banda Aceh dalam mendorong Pelaksanaan Inovasi Daerah di Kota Banda Aceh
Authors: Rahmanda Alfi Rizky
Published: January 2025

Problems in the public sector or government need to be solved through innovation. Innovation should be the focus of the government to do this with the aim of producing quality public services, shortening service time, and cutting bureaucracy. Law Number 23 of 2014 concerning Regional Government, has indicated that the obligation and authority for innovation does not only belong to the Central Government, but that the Regional Government has the same obligation. In increasing the innovation of a region, a strong and optimal research and development institution is needed in the framework of its implementation. This paper aims to look at the institutional capacity of the Banda Aceh City Regional Development Planning Agency (BAPPEDA) in encouraging the implementation of regional innovations in Banda Aceh City. This research uses descriptive qualitative method with data collection in the form of interviews with a number of informants, as well as through library research. The result of this research is that there is a need for institutional capacity building for BAPPEDA Kota Banda Aceh to encourage the implementation of regional innovations. It is necessary to increase the joint commitment of all parties, the existence of good conducive leadership, as well as institutional structural reform of BAPPEDA Banda Aceh. In addition, there is a need for an in-depth study related to the establishment of the Regional Innovation Research Agency (BRIDA) in order to encourage the implementation of regional research and innovation in the City of Banda Aceh.
Risk analysis of the promotion and access to oral health products through the figure of influencers in the social network Tiktok
Authors: Sandoval Frattallone Jeanna María José , Brusca Maria Isabel , Garzon Maria Laura , Vela Ferreira Atilio
Published: January 2025

The use of social media influencers has significantly transformed the promotion of dental products. These trendsetters, without dental training, disseminate information and recommend products that can have adverse effects on the oral health of their followers. In Argentina, the problem of intrusiveness in the dental profession has grown with the popularity of different platforms such as TikTok. This recent and understudied phenomenon poses significant risks to public health and the integrity of the dental profession
Tooth whitening and adherence of C.Albicans
Authors: Kees Marina Laura , Brusca María Isabel , Garzon María Laura , Vela Ferreira Atilio , Jewtuchowicz Virginia
Published: January 2025

Tooth whitening is nowadays one of the most requested aesthetic procedures by patients. Hydrogen peroxide contains unstable peroxides that produce oxygen free radicals, capable of breaking down the pigmented organic carbon components contained in the enamel matrix, converting them into shorter chain molecules and less pigmented, defined as oxidation, which continues for some time, and can decompose the organic materials into carbon dioxide and water, which would represent the loss of the enamel matrix1. One of the effects is the alteration of surface roughness and deeper cracks, as well as an increase in surface porosity, which could increase the adhesion of microorganisms. Objective: to determine if the adhesion of Candida albicans is greater in enamel subjected to bleaching with 35% hydrogen peroxide.Methods: The sample consisted of 20 healthy premolars extracted with orthodontic indication from patients between 13 and 35 years old with a post extraction time of less than 6 months.Two groups were randomly assigned, control group (no bleaching only sterile water) and experimental group (professional bleaching with 35% hydrogen peroxide). The teeth were sterilized and then incubated with Candida albicans for 36 hours. Then a sample of the vestibular side of the teeth was taken with sterile microbruhs to be centrifuged, and the seeding was performed in plates with sabouraud glucose agar from the supernatant of the centrifugation with a volume of 7 microliters, streaked with ansa. The CFU of both groups were quantified after 36 h of incubation in an oven at 37ºC.  Results: The data were processed in Excel through the real statistics add-in system, the Shapiro Wilk test was applied to determine the normal distribution of the data, the F test for variances of two samples which resulted in equal variances; therefore, the parametric T-student test for independent samples for equal variances was selected. The result for one-tailed analysis was P value of 0.04 so we can think that this difference between control and experimental group exists, and in which case there was greater adherence of Candida in the control group compared to the experimental group. Conclusion: The literature is controversial, we can assume that the greater adherence of Candida albicans in the control group was due to the antimicrobial action of the bleaching agent on the experimental group.
Causes and consequences of premature loss of primary teeth - literature review
Authors: Milivoy Ancieta , Brusca Maria Isabel , Garzon Maria Laura , Vela Ferreira Atilio
Published: January 2025

It is important to maintain the entire primary dentition until the time of replacement, since it can be affected by factors such as dental caries, premature exodontia and trauma, and can influence the physiological, psychological and social development of the child.The poor information that parents have on this subject plays an important role in the development of occlusion and in the dental care of their children.The objective of this work is to investigate the causes and consequences of premature loss of primary teeth.
Advancing Global Perspectives: Bridging Sustainability, Innovation, and Cultural Ethics in Management
Authors: Liu Bai
Published: January 2025

This issue explores the dynamic interplay between sustainability, innovation, and cultural ethics in management. The issue features four diverse contributions that address pressing challenges in management, including the integration of gender-sensitive leadership, the balance of cultural preservation and economic sustainability in ethnic minority settlements, the impact of green human resource management practices on environmental performance in developing countries, and the reconfiguration of business ethics from a Chinese perspective. Together, these articles exemplify the importance of interdisciplinary approaches and contextualized solutions in advancing global management research. By drawing on case studies, empirical analyses, and theoretical frameworks, this issue provides actionable insights for scholars, practitioners, and policymakers seeking to foster sustainable and inclusive management practices.
Sinais clínicos e tratamento da cetoacidose diabética
Authors: Medeiros Maria Eduarda Nunes de Figueiredo , Medeiros Maria Beatriz Nunes de Figueiredo , Oliveira Tarcísio Arêdes , Regis Julia Melissa Schimitt , Machado Gustavo Frederico Barbosa , Araújo Matheus Ramos Schwalb , Cantarutti Lorenna da Silva Santos , Giroto Caroline Prado , Moreira Ana Luiza Dias , Sarmento Gabrielle Nascimento da Paz , Nascimento João Paulo Silva do , Magalhães Aliandro Willy Duarte
Published: January 2025

O presente estudo revisou os sinais clínicos e o tratamento da cetoacidose diabética (CAD) por meio de uma abordagem de revisão integrativa. O objetivo foi avaliar e compreender os principais sinais clínicos associados à CAD, bem como os métodos terapêuticos mais eficazes para seu manejo. A metodologia consistiu em uma revisão integrativa realizada nas bases de dados Scientific Electronic Library Online (SCIELO), Cochrane e Medline, utilizando descritores como "Cetoacidose diabética", "Tratamento", "Diabetes mellitus" e "Distúrbios metabólicos". Os resultados indicaram que os sinais clínicos da CAD incluem hiperglicemia, respiração de Kussmaul, hálito cetônico e distúrbios eletrolíticos. O tratamento da CAD envolve a reposição de líquidos, administração de insulina intravenosa e monitoramento contínuo dos parâmetros metabólicos. Embora os tratamentos sejam eficazes e contribuam para a melhora clínica dos pacientes, o estudo aponta desafios, como a necessidade de diagnóstico precoce e a possibilidade de complicações graves, como edema cerebral. Conclui-se que a intervenção precoce e o manejo adequado são fundamentais para a redução da mortalidade e morbidade associadas à cetoacidose diabética.
PENGARUH PROMOSI DAN KUALITAS PELAYANANTERHADAP KEPUASAN PELANGGAN PADAPT ECCOMERCE CAPITAL INDONESIADI JAKARTA BARAT
Authors: Faizatul Faizatul Nisa , Sopandi Andi
Published: January 2025

ABSTRACT
 
The purpose of this research is to find out how much influence promotion has on customer satisfaction at PT Ecomerce Capital Indonesia in West Jakarta, to find out how big the influence of service quality is on customer satisfaction at PT Eccomerce Capital Indonesia in West Jakarta. and to find out how much influence promotion and service quality have on customer satisfaction at PT Ecomerce Capital Indonesia in West Jakarta". Both simultaneously. The research method in this research is a survey method. The population in this research is visitors to PT Eccomerce Capital Indonesia in West Jakarta" . totaling 1,978 customers. The sampling technique used was purpose method sampling, determining the sample size using the Slovin formula with a difficulty level of 10%, so a sample of 95 customer respondents was obtained. The test results for the promotion variable (X1) obtained a tcount value of 0.371 with a significance level of 0.711. This value is greater than 0.05 (0.711 > 0.05), so the equation obtained is tcount > ttable or 0.371 > 2.017, meaning Ho is accepted, Ha is rejected, in other words. Promotion variables have a significant effect on customer satisfaction. Meanwhile, the test results for the service quality variable (X2) obtained a calculated value of 3.645 with a significance level of 0.000. This value is smaller than 0.05 (0.000<0.05), so we get the equation tcount 2.017. This means that Ho is accepted and Ha is rejected. in other words, the service quality variable has a significant effect on customer satisfaction. Thus, it can be interpreted that promotion and service quality simultaneously have a significant influence on customer satisfaction.
 
Keywords: Promotion, Service Quality, Customer Satisfaction
Cognitive impairment in pulmonary arterial hypertension
Authors: Heller Sloane , See Claudia , Singh Inderjit , Fredericks Carolyn A.
Published: August 2023

Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary vascular remodeling with resultant abnormal increase in pulmonary artery pressure and right heart dysfunction. There is evidence that PAH includes cognitive impairment. However, the cognitive impairment syndrome has not been well described, and both the underlying mechanism and the relationship between cardiopulmonary and cognitive dysfunction in PAH are unknown. We performed cognitive evaluations and same day sub‐maximum cardiopulmonary exercise testing on adult subjects with PAH. A frontal–subcortical syndrome suggestive of vascular cognitive impairment was found in 26% of subjects and was associated with noninvasive markers of pulmonary vascular remodeling.
How long ago were the “good old days”? Comparing the prevalence of nostalgia in YouTube comments on music videos from recent versus distant decades
Authors: Areni Charles S. , Todres Mathew
Published: August 2023

Research on motives for using social media suggests competing hypotheses regarding how far back in time people vicariously travel to experience nostalgia online. Automated text analyses of user comments on 56 YouTube videos featuring Billboard Magazine's top 30 songs of the year from the 1950–2019 period identified clusters of co‐occurring words suggesting nostalgia. Boolean operators transformed the word clusters into sentence structures conveying nostalgia [e.g., (“miss” and ((“young” and “man”) or “days” or “times”)) → “I miss those days when I was a young man”]. Analysis of 37,217 comments revealed that the percentage expressing nostalgia was higher for videos from the 2000s–2010s compared to the 1950s–1980s. Social media has made instant online access to the recent past a normal part of daily life, making users more prone to expressing nostalgia toward relatively recent experiences.
Vacancy‐Ordered Superstructure‐Induced Delocalized States Enable Superior Sodium Ion Storage
Authors: Gao Yusha , Lv Ximeng , Lv Zhuoran , Peng Baixin , Zheng Gengfeng , Huang Fuqiang
Published: August 2023

Transition metal sulfides (TMSs) are perceived as competitive candidate anodes for sodium‐ion batteries (SIBs) on account of their high capacity and admirable reversibility. However, a majority of TMSs suffer from huge volume expansion and poor kinetics so they cannot achieve durable and fast Na+ storage. Herein, a cation vacancy‐ordered Cr2/3S is fabricated by extracting quantitative Cr atoms from nickel arsenide type CrS via sulfur “atomic pump,” that is, sulfur and particular sit Cr atoms are bonded to extend a new structure. The ordered vacancies not only construct a loosely‐packed crystal structure but also induce delocalized electron states of Cr atoms, hence effectively accelerating Na+ diffusion and releasing volume strain to enable high‐rate and longevous SIBs. The new Cr2/3S anode presents a high reversible capacity of 544 mAh g−1 after 100 cycles at 1 A g−1 and excellent high‐rate performance of ≈100% capacity retention after 7000 cycles at 20 A g−1. Subsequent in situ and ex situ characterizations reveal the Na+ storage mechanism of Cr2/3S. The proposed cation exaction strategy through an innovative sulfur “atomic pump” can be an efficient way to achieve loosely‐packed structure material for large‐capacity and fast‐kinetics anodes.
Stabilizing Li1.3Al0.3Ti1.7(PO4)3|Li Metal Anode Interface in Solid‐State Batteries by Kevlar Aramid Nanofiber‐Based Protective Coating
Authors: Kong Wenhan , Jiang Zhouyang , Liu Yangxi , Han Qingyue , Ding Liang‐Xin , Wang Suqing , Wang Haihui
Published: August 2023

Li1.3Al0.3Ti1.7(PO4)3 (LATP) solid‐state electrolyte has garnered considerable interest owing to its competitive room‐temperature Li‐ion conductivity, air stability, and economic nature. Nevertheless, the successful implementation of LATP in next‐generation Li‐metal solid‐state batteries (SSBs) is impeded by its high incompatibility with Li metal. Herein, combining the Kevlar aramid nanofiber (KANF) membrane with a solidified electrolyte (SE) formed via in situ polymerization, the SE@KANF protective layer for LATP can be constructed. Such a protective layer not only effectively prevents Li metal from reducing LATP but also provides intimate interface contact and limits unnecessary electron transport. Consequently, Li symmetric battery incorporating SE@KANF layer enables an ultrahigh critical current density of 1.4 mA cm−2 and stably cycles for over 2000 h at 0.2 mA cm−2. Moreover, the full SSB coupling with LiFePO4 cathode delivers a capacity retention of 95% after 180 cycles at 0.1 C at 30 °C. The present study underscores the importance of the protective interface layer in stabilizing the LATP|Li interface.
Composition Based Oxidation State Prediction of Materials Using Deep Learning Language Models
Authors: Fu Nihang , Hu Jeffrey , Feng Ying , Morrison Gregory , Loye Hans‐Conrad zur , Hu Jianjun
Published: August 2023

Oxidation states (OS) are the charges on atoms due to electrons gained or lost upon applying an ionic approximation to their bonds. As a fundamental property, OS has been widely used in charge‐neutrality verification, crystal structure determination, and reaction estimation. Currently, only heuristic rules exist for guessing the oxidation states of a given compound with many exceptions. Recent work has developed machine learning models based on heuristic structural features for predicting the oxidation states of metal ions. However, composition‐based oxidation state prediction still remains elusive so far, which has significant implications for the discovery of new materials for which the structures have not been determined. This work proposes a novel deep learning‐based BERT transformer language model BERTOS for predicting the oxidation states for all elements of inorganic compounds given only their chemical composition. This model achieves 96.82% accuracy for all‐element oxidation states prediction benchmarked on the cleaned ICSD dataset and achieves 97.61% accuracy for oxide materials. It is also demonstrated how it can be used to conduct large‐scale screening of hypothetical material compositions for materials discovery.
Polymer Chainmail: Steric Hindrance and Charge Compensation of Anion‐Doped PEDOT to Boost Stress Deformation of Compressible Supercapacitor
Authors: Xiao Bo‐Hao , Li Jian‐Xi , Xu Hong‐Yi , Huang Jia‐Le , Luo Yin‐Lin , Xiao Kang , Liu Zhao‐Qing
Published: August 2023

Conducting polymers with high theoretical capacitance and deformability are among the optimal candidates for compressible supercapacitor electrode materials. However, achieving both mechanical and electrochemical stabilities in a single electrode remains a great challenge. To address this issue, the “Polymer Chainmail” is proposed with reversible deformation capability and enhances stability because of the steric hindrance and charge compensation effect of doped anions. As a proof of concept, four common anions are selected as dopants for Poly(3,4‐ethylenedioxythiophene) (PEDOT), and their effects on the adsorption and diffusion of H+ on PEDOT are verified using density functional theory calculations. Owing to the film formation effect, the
doped PEDOT/nitrogen‐doped carbon foam exhibits good mechanical properties. Furthermore, the composite demonstrates excellent rate performance and stability due to suitable anion doping. This finding provides new insights into the preparation of electrochemically stable conductive polymer‐based compressible electrode materials.
Interfacial Assembly of Nanocrystals on Nanofibers with Strong Interaction for Electrocatalytic Nitrate Reduction
Authors: Zhang Fangzhou , Luo Jiamei , Chen Junliang , Luo Hongxia , Jiang Miaomiao , Yang Chenxi , Zhang Hui , Chen Jun , Dong Angang , Yang Jianping
Published: August 2023

One‐dimensional fiber architecture serves as an excellent catalyst support. The orderly arrangement of active materials on such a fiber substrate can enhance catalytic performance by exposing more active sites and facilitating mass diffusion; however, this remains a challenge. We developed an interfacial assembly strategy for the orderly distribution of metal nanocrystals on different fiber substrates to optimize their electrocatalytic performance. Using electrochemical nitrate reduction reaction (NO3−RR) as a representative reaction, the iron‐based nanofibers (Fe/NFs) assembly structure achieved an excellent nitrate removal capacity of 2317 mg N/g Fe and N2 selectivity up to 97.2 %. This strategy could promote the rational design and synthesis of fiber‐based electrocatalysts.
Tunable Fluorescence from 2D Assemblies of LnW10 and P2W18 Polyoxometalates Clusters with Quaternary Ammonium‐type AIEgens
Authors: Rong Shujian , Wang Mengshi , Wang Xun
Published: August 2023

Two‐dimensional (2D) AIE‐inorganic nanocomposites exhibit high stability and high fluorescence activity. However, limited by the types and properties of 2D inorganic materials, it's challenging to realize complex structures and functions. We designed a quaternary ammonium‐type AIE ligand, TPECholine. We chose TPECholine and POM clusters as building blocks and synthesized a series of single‐layer nanosheets (SLNSs) by assembling LnW10 or P2W18 POM clusters with TPECholine. By regulating the types of POM clusters and ligands, the morphology and fluorescence intensity of the SLNSs can be finely tuned. Due to the restriction of the intramolecular motions of AIEgens by the SLNSs, nanosheets can exhibit promoted quantum yield (up to 76 %). In addition, thanks to the sub‐nanometric sizes and excess surface charges, SLNSs exhibit excellent solvent compatibility, including water, chloroform, ethanol, etc. And the nanosheets showed high fluorescence intensity in these solvents.
Effect of calcium pimelate on crystallization kinetics of polyphenylene sulfide
Authors: Liu Huiqin , Feng Jiachun
Published: August 2023

The use of nucleating agents (NAs) to accelerate semicrystalline polymers crystallization is a widely recognized technique during processing. However, the commercially available NA for poly(phenylene sulfide) (PPS) has been rather limited. In this work, it is found that calcium pimelate (CaPim), a commercial nucleating agent for isotactic polypropylene, could also accelerate the crystallization process of PPS. The influence of CaPim addition on the crystallization behaviors of PPS was investigated under non‐isothermal and isothermal condition. Upon the addition of 0.3 wt% CaPim, the crystallization peak temperature and the onset crystallization temperature increases by 5.3 and 8.4°C at 10°C/min cooling rate, and the half‐time of crystallization reduces 51% at crystallization temperature of 272°C. Polarized optical observation revealed a substantial enhancement in nucleation due to the presence of CaPim. Avrami equation analysis suggested that the nucleating agent significantly increased the crystallization rate constant without affecting the growth dimension. Moreover, Lauritzen–Hoffman theory analysis indicateed that the addition of CaPim lowers the nucleation energy barrier, contributing to its high‐nucleation efficiency. These findings demonstrate that calcium pimelate holds promise as an effective nucleating agent for PPS.
Influence of microphase separation and crosslinking density on dynamic viscoelastic properties of nano‐Fe3O4 modified polyurethane
Authors: Yang Fukang , Gao Hanyang , Jiang Jiahao , Wang Mengjie , Hu Guoxin
Published: August 2023

Although there have been some studies on the preparation and characteristics of nano‐Fe3O4‐filled polyurethane (PU) composites, research focusing on the quantitative influence of the degree of microphase separation (DPS) and the crosslinking density (CLD) on dynamic viscoelastic properties is rare. In this paper, PU composites are synthesized by incorporating nano‐Fe3O4 as fillers. The dynamic mechanical properties under alternating loads are investigated using dynamic mechanical analysis. The influences of the DPS and the CLD on the dynamic hysteresis loss are analyzed. The experimental results show that the DPS and CLD of PU nanocomposites increase and then decrease with the increase of nano‐Fe3O4 addition and reached a maximum at the addition amount of 1.0 wt%. The quantitative relationships between DPS, CLD and the dynamic hysteresis loss of PU nanocomposites at different filler ratios are obtained. With a 1.0 wt% nano‐Fe3O4 content, the strain energy density (SED) and hysteresis energy density (HED) are increased by 416% and 354%, respectively. The hysteretic loss H indexes of all composites are kept lower than that of pure PU. These characteristics make nano‐Fe3O4‐filled PU a promising material for reducing the rolling resistance and increasing the service life of fuel‐saving tire materials.
Inserting urethane into 1,2,3‐triazole click‐cured solid propellant binder to form microphase separation and enhance mechanical and combustible performances
Authors: Zhang Shengda , Hu Wen , Gan Lin , Tang Gen , Guo Xiang , Pang Aimin , Huang Jin
Published: August 2023

Huisgen‐click curing systems are widely used in solid propellant binders due to their low humidity sensitivity and mild reaction conditions. However, the rigid triazole rings from the Huisgen‐click reaction decrease the molecular moving ability and increase decomposition temperature, lowering the mechanical and combustion performance. Thus, we bonded the Huisgen‐click system and polyester binders with urethane, forming microphase separation and improving chemical stability. The results show that the elongation at break, tensile strength, and Young's modulus of the binders increase by 533.3%, 201.2%, and 1263.9%, respectively. Furthermore, the urethane reduces the thermal resistance index of the binders from 191.2 to 179.2°C, which means better combustion performance. Further mechanism study reveals that the urethane leads to microphase separation, which aggregates the hard segments and weakens their restriction effect on the molecular motion of polyether. Such a microphase separation brings comprehensive improvement in the mechanical properties of the solid propellants and probably can be used in other multi‐component systems of energetic materials.
Complement
Authors: Monach Paul A.
Published: August 2023

The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized by immune‐complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications.
Improving parents' ability to advocate for services for youth with autism: A randomized clinical trial
Authors: Taylor Julie Lounds , DaWalt Leann Smith , Burke Meghan M. , Slaughter James C. , Xu Meng
Published: August 2023

Youth with autism face challenges accessing services as they transition to adulthood. Improving parents' ability to advocate for services on behalf of their youth may be an effective way to improve service access and ultimately transition outcomes in this group. In this study, we tested whether participating in an advocacy intervention improved parents' ability to advocate for services for their transition‐aged youth with autism. One hundred and eighty‐five parents of youth with autism ages 16–26, recruited across three states in the U.S., were randomized to one of two experimental conditions. The treatment condition received the ASSIST program, a 12‐week (24‐h) group‐based intervention. The control condition received the same written materials as the treatment condition. Primary outcomes for this report—parent advocacy ability—were collected at baseline (prior to randomization) and post‐test (immediately after the treatment group finished the 12‐week program) by survey. After taking ASSIST, the treatment condition had greater gains than controls in knowledge of adult services (B = −1.62, CI = −2.33 to −0.90) and perceived advocacy skills (B = −0.19, CI = −0.33 to −0.04). Participants who had less knowledge, lower perceived advocacy skills, and less active coping styles at baseline had the greatest treatment gains. Findings suggest that ASSIST is effective in improving parent advocacy ability and may be most beneficial for parents who experience greater challenges advocating for their son/daughter with autism. Future research will examine whether gains in parent advocacy ability leads to improvements in service access and post‐school outcomes for transition‐age youth with autism.
Membrane fusogenic nanoparticle‐based HLA‐peptide‐addressing universal T cell receptor‐engineered T (HAUL TCR‐T) cell therapy in solid tumor
Authors: Xu Ruihan , Wang Qin , Zhu Junmeng , Bei Yuncheng , Chu Yanhong , Sun Zhichen , Du Shiyao , Zhou Shujuan , Ding Naiqing , Meng Fanyan , Liu Baorui
Published: August 2023

T cell receptor‐engineered T (TCR‐T) cell therapy has demonstrated therapeutic effects in basic research and clinical trials for treating solid tumors. Due to the peptide‐dependent recognition and the human leukocyte antigen (HLA)‐restriction, TCR‐T cell therapy is generally custom designed to target individual antigens. The lack of suitable universal targets for tumor cells significantly limits its clinical applications. Establishing a universal TCR‐T treatment strategy is of great significance. This study designed and evaluated the HLA‐peptide‐addressing universal (HAUL) TCR‐T cell therapy based on HLA‐peptide (pHLA) loaded membrance fusogenic deliver system. The pHLA‐NP‐based tumor cell membrane modification technology can transfer the pHLA onto the surface of tumor cells through membrane fusogenic nanoparticles. Then tumor cells are recognized and killed by TCR‐T cells specifically. The HAUL TCR‐T cell therapy technology is a universal technology that enables tumor cells to be identified and killed by specific TCR‐T cells, regardless of the HLA typing of tumor cells.
Guanylate‐binding proteins signature predicts favorable prognosis, immune‐hot microenvironment, and immunotherapy response in hepatocellular carcinoma
Authors: Ning Yumei , Fang Shilin , Fang Jun , Lin Kun , Nie Haihang , Xiong Peiling , Qiu Peishan , Zhao Qiu , Wang Haizhou , Wang Fan
Published: August 2023

Background

The role of guanylate‐binding proteins (GBPs) in various cancers has been elucidated recently. However, our knowledge of the clinical relevance and biological characteristics of GBPs in hepatocellular carcinoma (HCC) remains limited.

Methods

A total of 955 HCC patients were enrolled from five independent public HCC cohorts. The role of GBP molecules in HCC was preliminarily investigated, and a GBP family signature, termed GBPs‐score, was constructed by principal component analysis to combine the GBP molecule values. We revealed the effects of GBP genes and GBPs‐score in HCC via well‐established bioinformatics methods and validated GBP1‐5 experimentally in a tissue microarray (TMA) cohort.

Results

GBPs molecules were closely associated with the prognosis of patients with HCC, and a high GBPs‐score highly inferred a favorable survival outcome. We also revealed high GBPs‐score was related to anti‐tumor immunity, the immune‐hot tumor microenvironment (TME), and immunotherapy response. Among the GBPs members, GBP1‐5 rather than GBP6/7 may be dominant in these fields. The TMA analysis based on immunohistochemistry showed positive correlations between GBP1‐5 and the immune‐hot TME with abundant infiltration of CD8+ T cells in HCC.

Conclusions

Our integrative study revealed the genetic and immunologic characterizations of GBPs in HCC and highlighted their potential values as promising biomarkers for prognosis and immunotherapy.
Patient‐reported outcomes in older breast cancer survivors with and without prior chemotherapy treatment
Authors: Adesoye Taiwo , Liao Kai‐Ping , Peterson Susan , Li Liang , Zorzi Daria , Holmes Holly M. , Chavez‐MacGregor Mariana , Giordano Sharon H.
Published: August 2023

Background

Little is known about long‐term treatment‐related symptoms in older breast cancer survivors. We characterized long‐term patient‐reported symptoms and examined factors associated with the presence and severity of symptoms, and symptom interference with daily activities.

Methods

Texas Cancer Registry (TCR) Medicare linkage data was used to identify breast cancer patients age 65 and older with local/regional stage disease diagnosed between 2012–2013. Symptom burden was assessed using breast‐specific items from the Patient‐Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO‐CTCAE™). Demographic and clinical data also were collected. Logistic regression models were used to assess the association between symptom burden and respondent sociodemographic and clinical characteristics.

Results

Of 4448 eligible patients, 1594 (response‐rate 35.8%) completed questionnaires. Of these, 1245 eligible respondents were included in the analysis based on self‐reported data. Median time from diagnosis to survey completion was 68 months (IQR: 62–73). Most frequently reported symptoms were fatigue/lack of energy (76.8%), aching muscles (72.1%) and aching joints (72.5%). Receipt of chemotherapy was associated with higher symptom burden. Patients treated with adjuvant chemotherapy had higher risk of numbness/tingling (OR: 3.16; 95% CI: 2.36–4.24), hair loss (OR: 2.72; 95% CI: 2.05–3.60), and fatigue/lack of energy (OR: 1.80; 95% CI: 1.29–2.52). Similarly, patients who received chemotherapy were more likely to report the majority of symptoms as moderate to severe and as interfering with daily activities.

Conclusion

Receipt of chemotherapy is associated with significant symptom burden more than 5 years after breast cancer treatment. Long‐term chemotherapy impact should be discussed with patients in a shared‐decision making process and approaches to symptom management during survivorship care are needed.
Disparities in pediatric cancer survivorship care: A systematic review
Authors: Mobley Erin M. , Moke Diana J. , Milam Joel , Ochoa‐Dominguez Carol Y. , Stal Julia , Mitchell Halle , Aminzadeh Naghmeh , Bolshakova Maria , Mailhot Vega Raymond B. , Dinalo Jennifer , Motala Aneesa , Hempel Susanne
Published: August 2023

Background

Childhood cancer survivors (CCS) experience many long‐term health problems that can be mitigated with recommended survivorship care. However, many CCS do not have access to survivorship care nor receive recommended survivorship care. We reviewed the empirical evidence of disparities in survivorship care for CCS.

Methods

This systematic review searched PubMed, CINAHL, and PsycINFO for studies on survivorship care for CCS (PROSPERO: CRD42021227965) and abstracted the reported presence or absence of disparities in care. We screened 7945 citations, and of those, we reviewed 2760 publications at full text.

Results

A total of 22 studies reported in 61 publications met inclusion criteria. Potential disparities by cancer treatment (N = 14), diagnosis (N = 13), sex (N = 13), and current age (N = 13) were frequently studied. There was high quality of evidence (QOE) of survivorship care disparities associated with non‐White race, Hispanic ethnicity, and being uninsured. Moderate QOE demonstrated disparities among CCS who were unemployed and older. Lower QOE was found for disparities based on cancer diagnosis, cancer treatment, age at diagnosis, time since diagnosis, sex, insurance type, income, educational attainment, and geographic area.

Conclusions

We found strong empirical evidence of disparities in survivorship care for CCS associated with race, ethnicity, and insurance status. Multiple other disparate groups, such as those by employment, income, insurance type, education, cancer diagnosis, age at diagnosis, time since diagnosis, cancer treatment, geographic area, sex, and self‐identified gender warrant further investigation. Prospective, multilevel research is needed to examine the role of other patient characteristics as potential disparities hindering adequate survivorship care in CCS.
Quinoline Hydrazone Derivatives as New Antibacterials against Multidrug Resistant Strains
Authors: Hodyna Diana , Kovalishyn Vasyl , Romanenko Yanina , Semenyuta Ivan , Blagodatny Volodymyr , Kachaeva Maryna , Brazhko Oleksandr , Metelytsia Larysa
Published: August 2023

To develop novel antimicrobial agents a series of 2(4)‐hydrazone derivatives of quinoline were designed, synthesized and tested. QSAR models of the antibacterial activity of quinoline derivatives were developed by the OCHEM web platform using different machine learning methods. A virtual set of quinoline derivatives was verified with a previously published classification model of anti‐E. coli activity and screened using the regression model of anti‐S. aureus activity. Selected and synthesized 2(4)‐hydrazone derivatives of quinoline exhibited antibacterial activity against the standard and antibiotic‐resistantS. aureusandE. colistrains in the range from 15 to 30 mm by the diameter of growth inhibition zones. Molecular docking showed the complex formation of the studied compounds into the catalytic domain of dihydrofolate reductase with an estimated binding affinity from −8.4 to −9.4 kcal/mol.
Aspirin‐induced urticaria in a recently diagnosed ischemic stroke patient: A case report and literature review
Authors: Dahal Abhinav , Gautam Sushant , Shakya Aliza , Pant Ashmita , Bhandari Kriti , Shrestha Shumneva , Shrestha Sajina , Shrestha Abhigan Babu
Published: August 2023

Key Clinical Message

NSAIDs may be rare but an important cause of urticarial which should not be missed.

The aspirin and urticaria correlation has not been fully understood. The pharmacological inference is suspected to be the diversion of arachidonic acid metabolism. Aspirin sensitivity can aggravate preexisting chronic urticaria and in some instances causes acute urticaria. We report a case of a 53‐year‐old male, recently diagnosed with a stroke, who presented with complaints of multiple rashes over the trunk and upper extremities with aspirin. NSAIDs induced urticarial are usually neglected by physicians during diagnosis.
The Best of Both Worlds: Combining the Power of MICs and WCAs To Generate Stable and Crystalline CrI‐Tetracarbonyl Complexes with π‐Accepting Ligands
Authors: Bens Tobias , Walter Robert R. M. , Beerhues Julia , Schmitt Manuel , Krossing Ingo , Sarkar Biprajit
Published: August 2023

Invited for the cover of this issue are Biprajit Sarkar and co‐workers at the University of Stuttgart and University of Freiburg. In the image, the solar flare represents the non‐innocence (fluorine‐specific interactions) of the counterion, and the black hole at the metal center illustrates the oxidation/electron deficiency of the Cr‐center, while the electron “gets lost” in the space (oxidation agent). Read the full text of the article at 10.1002/chem.202301205.
Effect of infant viral respiratory disease on childhood asthma in a non‐industrialized setting
Authors: Atwell Jessica , Chico Martha , Vaca Maritza , Arévalo‐Cortes Andrea , Karron Ruth , Cooper Philip J.
Published: August 2023

Background

There are limited data from non‐industrialized settings on the effects of early life viral respiratory disease on childhood respiratory illness. We followed a birth cohort in tropical Ecuador to understand how early viral respiratory disease, in the context of exposures affecting airway inflammation including ascariasis, affect wheezing illness, asthma, and rhinoconjunctivitis in later childhood.

Methods

A surveillance cohort nested within a birth cohort was monitored for respiratory infections during the first 2 years in rural Ecuador and followed for 8 years for the development of wheeze and rhinoconjunctivitis. Nasal swabs were examined for viruses by polymerase chain reaction and respiratory symptom data on recent wheeze and rhinoconjunctivitis were collected by periodic questionnaires at 3, 5, and 8 years. Stools from pregnant mothers and periodically from children aged 2 years were examined microscopically for soil‐transmitted helminths. Atopy was measured by allergen skin prick testing at 2 years. Spirometry, fractional exhaled nitric oxide measurement, and nasal washes were performed at 8 years. Associations between clinically significant respiratory disease (CSRD) and wheezing or rhinoconjunctivitis at 3, 5, and 8 years were estimated using multivariable logistic regression.

Results

Four hundred and twenty six children were followed of which 67.7% had at least one CSRD episode; 12% had respiratory syncytial virus (RSV)+CSRD and 36% had rhinovirus (RHV)+CSRD. All‐cause CSRD was associated with increased wheeze at 3 (OR 2.33 [95% confidence intervals (CI) 1.23–4.40]) and 5 (OR: 2.12 [95% CI 1.12–4.01]) years. RHV+CSRD was more strongly associated with wheeze at 3 years in STH‐infected (STH‐infected [OR 13.41, 95% CI 1.56–115.64] vs. uninfected [OR 1.68, 95% CI 0.73–3.84]) and SPT+ (SPT+ [OR 9.42, 95% CI 1.88–47.15] versus SPT‐ [OR 1.92, 95% CI 0.84–4.38]) children. No associations were observed between CSRD and rhinoconjunctivitis.

Discussion

CSRD was significantly associated with childhood wheeze with stronger associations observed for RHV+CSRD in SPT+ and STH‐infected children.