bluuebunny/crossref_metadata_2025 huggingface dataset:
Record high Tc element superconductivity achieved in titanium
Authors: Zhang Changling , He Xin , Liu Chang , Li Zhiwen , Lu Ke , Zhang Sijia , Feng Shaomin , Wang Xiancheng , Peng Yi , Long Youwen , Yu Richeng , Wang Luhong , Prakapenka Vitali , Chariton Stella , Li Quan , Liu Haozhe , Chen Changfeng , Jin Changqing
Published: September 2022

It is challenging to search for high Tc superconductivity (SC) in transition metal elements wherein d electrons are usually not favored by conventional BCS theory. Here we report experimental discovery of surprising SC up to 310 GPa with Tc above 20 K in wide pressure range from 108 GPa to 240 GPa in titanium. The maximum Tconset above 26.2 K and zero resistance Tczero of 21 K are record high values hitherto achieved among element superconductors. The Hc2(0) is estimated to be ∼32 Tesla with coherence length 32 Å. The results show strong s-d transfer and d band dominance, indicating correlation driven contributions to high Tc SC in dense titanium. This finding is in sharp contrast to the theoretical predications based on pristine electron-phonon coupling scenario. The study opens a fresh promising avenue for rational design and discovery of high Tc superconductors among simple materials via pressure tuned unconventional mechanism.
Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth
Authors: Hall Trent D. , Kim Hyunjin , Dabbah Mahmoud , Myers Jacquelyn A. , Crawford Jeremy Chase , Morales-Hernandez Antonio , Caprio Claire E. , Sriram Pramika , Kooienga Emilia , Derecka Marta , Obeng Esther A. , Thomas Paul G. , McKinney-Freeman Shannon
Published: September 2022

While adult bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) and their extrinsic regulation is well studied, little is known about the composition, function, and extrinsic regulation of the first HSPCs to enter the BM during development. Here, we functionally interrogate murine BM HSPCs from E15.5 through P0. Our work reveals that fetal BM HSPCs are present by E15.5, but distinct from the HSPC pool seen in fetal liver, both phenotypically and functionally, until near birth. We also generate a transcriptional atlas of perinatal BM HSPCs and the BM niche in mice across ontogeny, revealing that fetal BM lacks HSPCs with robust intrinsic stem cell programs, as well as niche cells supportive of HSPCs. In contrast, stem cell programs are preserved in neonatal BM HSPCs, which reside in a niche expressing HSC supportive factors distinct from those seen in adults. Collectively, our results provide important insights into the factors shaping hematopoiesis during this understudied window of hematopoietic development.
Enabling scalable optical computing in synthetic frequency dimension using integrated cavity acousto-optics
Authors: Zhao Han , Li Bingzhao , Li Huan , Li Mo
Published: September 2022

Optical computing with integrated photonics brings a pivotal paradigm shift to data-intensive computing technologies. However, the scaling of on-chip photonic architectures using spatially distributed schemes faces the challenge imposed by the fundamental limit of integration density. Synthetic dimensions of light offer the opportunity to extend the length of operand vectors within a single photonic component. Here, we show that large-scale, complex-valued matrix-vector multiplications on synthetic frequency lattices can be performed using an ultra-efficient, silicon-based nanophotonic cavity acousto-optic modulator. By harnessing the resonantly enhanced strong electro-optomechanical coupling, we achieve, in a single such modulator, the full-range phase-coherent frequency conversions across the entire synthetic lattice, which constitute a fully connected linear computing layer. Our demonstrations open up the route toward the experimental realizations of frequency-domain integrated optical computing systems simultaneously featuring very large-scale data processing and small device footprints.
Humidity-sensitive chemoelectric flexible sensors based on metal-air redox reaction for health management
Authors: Li Shuo , Zhang Yong , Liang Xiaoping , Wang Haomin , Lu Haojie , Zhu Mengjia , Wang Huimin , Zhang Mingchao , Qiu Xinping , Song Yafeng , Zhang Yingying
Published: September 2022

Numerous studies have shown flexible electronics play important roles in health management. The way of power supply is always an essential factor of devices and self-powered ones are very attractive because of the fabrication easiness, usage comfort and aesthetics of the system. In this work, based on the metal-air redox reaction, which is usually used in designing metal-air batteries, we design a self-powered chemoelectric humidity sensor where a silk fibroin (SF) and LiBr gel matrix containing parallel aligned graphene oxide (GO) flakes serve as the electrolyte. The abundant hydrophilic groups in GO/SF and the hygroscopicity of LiBr lead to tight dependence of the output current on the humidity, enabling the sensor high sensitivity (0.09 μA/s/1%), fast response (1.05 s) and quick recovery (0.80 s). As proofs of concept, we design an all-in-one respiratory monitoring-diagnosing-treatment system and a non-contact human-machine interface, demonstrating the applications of the chemoelectric humidity sensor in health management.
Integrated wafer-scale ultra-flat graphene by gradient surface energy modulation
Authors: Gao Xin , Zheng Liming , Luo Fang , Qian Jun , Wang Jingyue , Yan Mingzhi , Wang Wendong , Wu Qinci , Tang Junchuan , Cao Yisen , Tan Congwei , Tang Jilin , Zhu Mengjian , Wang Yani , Li Yanglizhi , Sun Luzhao , Gao Guanghui , Yin Jianbo , Lin Li , Liu Zhongfan , Qin Shiqiao , Peng Hailin
Published: September 2022

The integration of large-scale two-dimensional (2D) materials onto semiconductor wafers is highly desirable for advanced electronic devices, but challenges such as transfer-related crack, contamination, wrinkle and doping remain. Here, we developed a generic method by gradient surface energy modulation, leading to a reliable adhesion and release of graphene onto target wafers. The as-obtained wafer-scale graphene exhibited a damage-free, clean, and ultra-flat surface with negligible doping, resulting in uniform sheet resistance with only ~6% deviation. The as-transferred graphene on SiO2/Si exhibited high carrier mobility reaching up ~10,000 cm2 V−1 s−1, with quantum Hall effect (QHE) observed at room temperature. Fractional quantum Hall effect (FQHE) appeared at 1.7 K after encapsulation by h-BN, yielding ultra-high mobility of ~280,000 cm2 V−1 s−1. Integrated wafer-scale graphene thermal emitters exhibited significant broadband emission in near-infrared (NIR) spectrum. Overall, the proposed methodology is promising for future integration of wafer-scale 2D materials in advanced electronics and optoelectronics.
The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure
Authors: Ito Shogo , Hashimoto Hisayuki , Yamakawa Hiroyuki , Kusumoto Dai , Akiba Yohei , Nakamura Takahiro , Momoi Mizuki , Komuro Jin , Katsuki Toshiomi , Kimura Mai , Kishino Yoshikazu , Kashimura Shin , Kunitomi Akira , Lachmann Mark , Shimojima Masaya , Yozu Gakuto , Motoda Chikaaki , Seki Tomohisa , Yamamoto Tsunehisa , Shinya Yoshiki , Hiraide Takahiro , Kataoka Masaharu , Kawakami Takashi , Suzuki Kunimichi , Ito Kei , Yada Hirotaka , Abe Manabu , Osaka Mizuko , Tsuru Hiromi , Yoshida Masayuki , Sakimura Kenji , Fukumoto Yoshihiro , Yuzaki Michisuke , Fukuda Keiichi , Yuasa Shinsuke
Published: September 2022

Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy. Here, we show that the right ventricle predominantly expresses alternative complement pathway-related genes, including Cfd and C3aR1. Complement 3 (C3)-knockout attenuates right ventricular dysfunction and fibrosis in a mouse model of right ventricular failure. C3a is produced from C3 by the C3 convertase complex, which includes the essential component complement factor D (Cfd). Cfd-knockout mice also show attenuation of right ventricular failure. Moreover, the plasma concentration of CFD correlates with the severity of right ventricular failure in patients with chronic right ventricular failure. A C3a receptor (C3aR) antagonist dramatically improves right ventricular dysfunction in mice. In summary, we demonstrate the crucial role of the C3-Cfd-C3aR axis in right ventricular failure and highlight potential therapeutic targets for right ventricular failure.
Unveiling Weyl-related optical responses in semiconducting tellurium by mid-infrared circular photogalvanic effect
Authors: Ma Junchao , Cheng Bin , Li Lin , Fan Zipu , Mu Haimen , Lai Jiawei , Song Xiaoming , Yang Dehong , Cheng Jinluo , Wang Zhengfei , Zeng Changgan , Sun Dong
Published: September 2022

Elemental tellurium, conventionally recognized as a narrow bandgap semiconductor, has recently aroused research interests for exploiting Weyl physics. Chirality is a unique feature of Weyl cones and can support helicity-dependent photocurrent generation, known as circular photogalvanic effect. Here, we report circular photogalvanic effect with opposite signs at two different mid-infrared wavelengths which provides evidence of Weyl-related optical responses. These two different wavelengths correspond to two critical transitions relating to the bands of different Weyl cones and the sign of circular photogalvanic effect is determined by the chirality selection rules within certain Weyl cone and between two different Weyl cones. Further experimental evidences confirm the observed response is an intrinsic second-order process. With flexibly tunable bandgap and Fermi level, tellurium is established as an ideal semiconducting material to manipulate and explore chirality-related Weyl physics in both conduction and valence bands. These results are also directly applicable to helicity-sensitive optoelectronics devices.
High-quality metagenome-assembled genomes from proximal colonic microbiomes of synbiotic-treated korean native black pigs reveal changes in functional capacity
Authors: Jung Jaehoon , Bugenyi Andrew W. , Lee Ma-Ro , Choi Yeon-Jae , Song Ki-Duk , Lee Hak-Kyo , Son Young-Ok , Lee Dong-Sun , Lee Sang-Chul , Son Young-June , Heo Jaeyoung
Published: September 2022

Synbiotics are feed supplements with the potential to promote health and productivity in pigs partly, through modulation of the intestinal microbiome. Our study used shotgun sequencing and 16S rRNA gene sequencing techniques to characterize the effect of a synbiotic containing three Lactobacillus species and a fructo-oligosaccharide on the proximal colonic microbiome of 4- to 7-month-old Korean native black gilts. With shotgun sequencing we constructed unique metagenome-assembled genomes of gut microbiota in Native Black Pig for the first time, which we then used for downstream analysis. Results showed that synbiotic treatment did not alter microbial diversity and evenness within the proximal colons, but altered composition of some members of the Lactobacillaceae, Enterococcaceae and Streptococcaceae families. Functional analysis of the shotgun sequence data revealed 8 clusters of orthologous groups (COGs) that were differentially represented in the proximal colonic microbiomes of synbiotic-treated Jeju black pigs relative to controls. In conclusion, our results show that administering this synbiotic causes changes in the functional capacity of the proximal colonic microbiome of the Korean native black pig. This study improves our understanding of the potential impact of synbiotics on the colonic microbiome of Korean native black pigs.
Drought characterization over Indian sub-continent using GRACE-based indices
Authors: Rawat Shivam , Ganapathy Abinesh , Agarwal Ankit
Published: September 2022

Drought is a natural disaster affects water resources, agriculture, and social and economic development due to its long-term and frequent occurrence. It is crucial to characterize and monitor drought and its propagation to minimize the impact. However, spatiotemporal assessment of drought characteristics over India at the sub-basin scale based on terrestrial water storage is unexplored. In this study, the Terrestrial water storage anomalies (TWSA) obtained from a Gravity Recovery and Climate Experiment and precipitation data are used to characterize the propagation of drought. Combined Climatological Deviation Index (CCDI) and GRACE-Drought Severity Index (GRACE-DSI) were computed as CCDI utilizes both precipitation and TWSA data while GRACE-DSI uses only TWSA data. Our results showed that GRACE-DSI exhibits significant negative trends over most of the Indian sub-basins compared to CCDI, indicating that most of the drought events are due to depletion of TWS. While other sub-basins show changing trends for GRACE-DSI and CCDI. The number of sub-basins showing significant negative trends for GRACE-DSI is more than that for CCDI. Hence TWS is depleting for most of the subbasins in India. Our results show that Indo-Gangetic plains face many drought events during 2002–2004, 2009–2014 & 2015–2017. Maximum drought duration and drought severity obtained for the area of North Ladakh (not draining into Indus basins) by GRACE-DSI are 26 months (2002–2004) and − 44.2835, respectively. The maximum drought duration and drought severity obtained for the Shyok sub-basin by CCDI is 17 months (2013–2015) and − 13.4392, respectively. Monthly trend analysis revealed that 39 & 23 no. of sub-basins show significant negative GRACE-DSI trends for October and CCDI for November, respectively. At the same time, the seasonal trend shows that total 34 and 14 sub-basins exhibited a significant negative trend at post-monsoon Kharif season for both the GRACE-DSI & CCDI, respectively.
An association between multi-morbidity and depressive symptoms among Indian adults based on propensity score matching
Authors: Singh Saurabh , Shri Neha , Dwivedi Laxmi Kant
Published: September 2022

Keeping in view the cascade of disturbances caused by the co-existence of multi-morbidity and depression among aged population, this study aims to ascertain the independent impact of multi-morbidity as a risk factor for the development of depressive symptoms among adults living in India. The present study utilizes data from the nationally representative survey “Longitudinal Ageing Study in India” (LASI, Wave-1, 2017–2018). The eligible sample size was 62,244 adults aged 45 years and above. Descriptive statistics along with bivariate analysis was used to understand the prevalence of depressive symptoms. Further, binary logistic regression and Propensity Score Matching (PSM) methods were applied to examine the independent effect of multi-morbidity on depressive symptoms while controlling the selected background characteristics. Overall, around one-third respondents had at least one chronic disease and one-fifth had multi-morbidity. The most prevalent chronic disease reported in the sampled population was hypertension followed by diabetes and joint disease. It is observed that older adults with multiple chronic diseases had 77% higher odds of having depressive symptoms as compared to those without a history of chronic disease in the multivariable logistic regression model. Results obtained from PSM indicate that the risk of having depressive symptoms was 3.7% higher for adults with multi- morbidity. Depressive symptom was identified to be associated with a wider range of multiple physical health problems and people with multi-morbidity are at a higher risk of having depressive symptoms. It is imperative that multi-morbidity can be used as a screener for identifying people with depressive symptoms.
The synergy between diurnal temperature range and calcium concentration help to predict hospital mortality in patients with acute myocardial infarction
Authors: Gu Xingbo , Liu Dandan , Hao Ning , Sun Xinyong , Liu Shulei , Duan Xiaoxu , Yang Shuang , Li Jia , Wang Shu
Published: September 2022

Epidemiological studies have suggested that cold is an important contributor to acute cardiovascular events and mortality. However, little is known about the Diurnal Temperature Range (DTR) impact on mortality of the patients with myocardial infarction. Calcium ions (Ca2+) play a vital role in the human body, such as cardiac electrophysiology and contraction. To investigate whether DTR on admission moderates the association between serum calcium and in-hospital mortality in patients with acute myocardial infarction (AMI). This retrospective study enrolled consecutive adult patients with AMI at a single center in China (2003–2012). Patients were divided into four groups (Ca-Q1–4) according to serum calcium concentration quartiles. Multivariate logistic regression modeling was used to assess whether DTR moderated the association between serum calcium and in-hospital mortality. The predictive value of serum calcium was evaluated by receiver operating characteristic (ROC) curve and net reclassification improvement (NRI) analyses. The study included 3780 patients. In-hospital mortality was 4.97% (188/3780). DTR moderated the association between serum calcium and in-hospital mortality (P-interaction = 0.020). Patients with low serum calcium in the highest DTR quartile exhibited an increased risk of in-hospital mortality (odds ratio for Ca-Q4 vs. Ca-Q1, 0.03; 95% confidence interval [95% CI], 0.01–0.20). In the highest DTR quartile, adding serum calcium concentration to the risk factor model increased the area under the ROC curve (0.81 vs. 0.76; P < 0.001) and increased NRI by 20.2% (95% CI 7.5–32.9; P = 0.001). Low serum calcium was an independent risk factor for in-hospital mortality in patients with AMI, and this association was moderated by DTR. Careful attention should be paid to patients with low serum calcium who experience a higher DTR on admission.
[4-(3-Amino-4-mehoxy-5-methylphenyl)-1-oxo-1H-phthalaz-2-yl] acetic acid hydrazide and its synergetic effect with KI as a novel inhibitor for low carbon steel corrosion in 0.5 M H2SO4
Authors: Abdullah Rokaia Safwat , Barghout Nehal A. , El-Sakka Sahar S. A. , Soliman Mohamed H. , El-Hashash Maher A. , Ragab Safaa , El Nemr Ahmed
Published: September 2022

We report the synthesis of novel [4-(3-amino-4-mehoxy-5-methyl phenyl)-1-oxo-1H-phthalaz-2-yl] acetic acid hydrazide (APPH), followed by its characterization using X-ray diffraction (XRD), Fourier transforms infrared (FT-IR) spectroscopy,1H-NMR spectroscopy, and LC/MS. Further, the inhibition effect of the varying concentration ofAPPHon the corrosion of low steel (LCS) in 0.5 M H2SO4was investigated by weight loss and electrochemical measurements at 30 °C. The percentage inhibition efficacy of APPH increased with concentration and reached about 84% at 0.5 mM at 30 °C, also rising to 88% after 6 h of exposure. According to the polarization measurements, the investigatedAPPHworks as a mixed-type inhibitor. Furthermore, the synergistic corrosion inhibition mechanismAPPHshowed that the inhibition efficiency maximizes with increasing inhibitor concentration, and the maximum value was 83% at 0.5 mMAPPH. The adsorption ofAPPHon the LCS surface is more fitting to the Langmuir isotherm model. The free energy value (–ΔG° ads) was 33.3 kJ mol−1. Quantum chemical calculation was applied toAPPHand acted as excellent support for the experimental data.
The CUN-BAE, Deurenberg Fat Mass, and visceral adiposity index as confident anthropometric indices for early detection of metabolic syndrome components in adults
Authors: López-González A. A. , Jover A. Martínez , Martínez C. Silveira , Artal P. Martínez , Bote S. Arroyo , Jané Bárbara Altisench , Ramírez-Manent J. I.
Published: September 2022

There is no definition for the metabolic syndrome; visceral obesity, elevated lipids and glucose, and hypertension coexist. The aim of the study is to determine which anthropometric indicators best determine it. Cross-sectional study in 418,343 Spanish workers. Metabolic syndrome was determined using the NCEP-ATPIII, IDF and JIS criteria. The anthropometric variables studied were: body mass index, waist circumference, waist-to-height ratio, CUNBAE, Deuremberg formula, body fat index, body surface index, normalized weight adjusted index, body roundness index, body shape index, visceral adiposity index (VAI), dysfunctional adiposity index, conicity index, metabolic score for visceral fat (METS-VF), waist triglyceride index. In men, the anthropometric indices with the largest areas under the ROC curve are VAI with ATPIII criteria and JIS. If we use the IDF criteria: waist circumference and METS-VF, with the same result. In women, the largest areas under the curve were observed with the Deuremberg formula in both ATPIII and JIS while with the IDF criteria it is METS-VF. The most useful anthropometric indices for identifying metabolic syndrome are CUN-BAE and Deuremberg, followed by the VAI. A single definition of metabolic syndrome should be agreed to determine the best anthropometric index with predictive capacity for its diagnosis.
Interactome based identification and validation of prefoldin 5-α for prognosing CNS leukemia in B-ALL patients
Authors: Xavier Tessy , Vijayachandran Lakshmi Sumitra , Chandran Rumamol , Mony Ullas , Augustine Anitha , Sidharthan Neeraj , Ganapathy Rema , Keechilat Pavithran , Sundaram K R. , Menon Krishnakumar N.
Published: September 2022

We report here the identification and validation of prefoldin 5-alpha (PFDN5-α) for the first time as prognostic biomarker for prediction of central nervous system (CNS) leukemia of B cell acute lymphoblastic leukemia (B-ALL) origin. Since cerebrospinal fluid (CSF) cytology being the gold standard of diagnosis for CNS leukemia with poor sensitivity, mandatory prophylactic intrathecal chemotherapy is administered irrespective of patients develop CNS leukemia. Thus, using interactome studies, we identified PFDN5-α as a prognostic biomarker for predicting CNS leukemia by interacting lymphoblastic proteins and CSF from B-ALL patients using far-western clinical proteomics approach. Validation by both western and ELISA methods confirmed our results. For further clinical translation, we performed Receiver Operating Characteristic (ROC) curve analysis generated from CNS +ve (n = 25) and −ve (n = 40) CSF samples from B-ALL patients and identified PFDN5-α-CSF reactivity cut-off value as 0.456. Values below 0.456 indicate the patient is at risk of developing CNS leukemia and suggestive of having intrathecal chemotherapy. Further flow cytometry validation for CNS leukemia positivity revealed that with increasing blast cells, a decrease in PFDN5-α-CSF reactivity confirming ELISA based PFDN5α-CSF reactivity assay. Predicting CNS leukemia development risk by ELISA based PFDN5-α-CSF reactivity assay could have potential in the clinical management of CNS leukemia.
Efficient removal of noxious methylene blue and crystal violet dyes at neutral conditions by reusable montmorillonite/NiFe2O4@amine-functionalized chitosan composite
Authors: Gomaa Hassanien , Abd El-Monaem Eman M. , Eltaweil Abdelazeem S. , Omer Ahmed M.
Published: September 2022

The jeopardy of the synthetic dyes effluents on human health and the environment has swiftly aggravated, threatening human survival. Hence, sustained studies have figured out the most acceptable way to eliminate this poisonous contaminant. Thereby, our investigation aimed to fabricate montmorillonite/magnetic NiFe2O4@amine-functionalized chitosan (MMT-mAmCs) composite as a promising green adsorbent to remove the cationic methylene blue (MB) and crystal violet (CV) dyes from the wastewater in neutral conditions. Interestingly, MMT-mAmCs composite carries high negative charges at a wide pH range from 4 to 11 as clarified from zeta potential measurements, asserting its suitability to adsorb the cationic contaminants. In addition, the experimental study confirmed that the optimum pH to adsorb both MB and CV was pH 7, inferring the ability of MMT-mAmCs to adsorb both cationic dyes in simple process conditions. Furthermore, the ferromagnetic behavior of the MMT-mAmCs composite is additional merit to our adsorbent that provides facile, fast, and flawless separation. Notably, the as-fabricated composite revealed an auspicious adsorbability towards the adsorptive removal of MB and CV, since the maximum adsorption capacity of MB and CV were 137 and 118 mg/g, respectively. Moreover, the isotherm and kinetic investigatins depicted that the adsorption of both cationic dyes fitted Langmuir and Pseudo 2nd order models, respectively. Besides, the advanced adsorbent preserved satisfactory adsorption characteristics with maximal removal efficacy exceeding 87% after reuse for ten consecutive cycles. More importantly, MMT-mAmCs efficiently adsorbed MB and CV from real agricultural water, Nile river water and wastewater samples at the neutral pH medium, reflecting its potentiality to be a superb reusable candidate for adsorptive removal cationic pollutants from their aquatic media.
Recording of pig neuronal activity in the comparative context of the awake human brain
Authors: Dobariya Aksharkumar , El Ahmadieh Tarek Y. , Good Levi B. , Hernandez-Reynoso Ana G. , Jakkamsetti Vikram , Brown Ronnie , Dunbar Misha , Ding Kan , Luna Jesus , Kallem Raja Reddy , Putnam William C. , Shelton John M. , Evers Bret M. , Azami Amirhossein , Geramifard Negar , Cogan Stuart F. , Mickey Bruce , Pascual Juan M.
Published: September 2022

Gyriform mammals display neurophysiological and neural network activity that other species exhibit only in rudimentary or dissimilar form. However, neural recordings from large mammals such as the pig can be anatomically hindered and pharmacologically suppressed by anesthetics. This curtails comparative inferences. To mitigate these limitations, we set out to modify electrocorticography, intracerebral depth and intracortical recording methods to study the anesthetized pig. In the process, we found that common forms of infused anesthesia such as pentobarbital or midazolam can be neurophysiologic suppressants acting in dose-independent fashion relative to anesthetic dose or brain concentration. Further, we corroborated that standard laboratory conditions may impose electrical interference with specific neural signals. We thus aimed to safeguard neural network integrity and recording fidelity by developing surgical, anesthesia and noise reduction methods and by working inside a newly designed Faraday cage, and evaluated this from the point of view of neurophysiological power spectral density and coherence analyses. We also utilized novel silicon carbide electrodes to minimize mechanical disruption of single-neuron activity. These methods allowed for the preservation of native neurophysiological activity for several hours. Pig electrocorticography recordings were essentially indistinguishable from awake human recordings except for the small segment of electrical activity associated with vision in conscious persons. In addition, single-neuron and paired-pulse stimulation recordings were feasible simultaneously with electrocorticography and depth electrode recordings. The spontaneous and stimulus-elicited neuronal activities thus surveyed can be recorded with a degree of precision similar to that achievable in rodent or any other animal studies and prove as informative as unperturbed human electrocorticography.
Study of a Si-based light initiated multi-gate semiconductor switch for high temperatures
Authors: Luan Chongbiao , Liu Hongwei , Fu Jiabin , He Yang , Xu Le , Wang Lingyun , Yuan Jianqiang , Xiao Longfei , Feng Zhuoyun , Huang Yupeng
Published: September 2022

Light initiated multi-gate semiconductor switch (LIMS) is a kind of power electronic device which has many differences from traditional thyristor triggered by electric pulse. LIMS is triggered by laser, the turn-on time is smaller, and the anti-electromagnetic interferences is strong. The opening mode of LIMS is obviously different to traditional thyristor. After the laser into the gate area, a large number of electrons and holes will appear in P-base region, holes gather in the area of P-base in PN junction J2, and electrons gather in N-drift region around the PN junction J2. PN junction J2 will open first, then PN junction J3 opens. The delay time of the NPN and PNP thyristors is close to zero when the laser pulse is narrow and the peak power is high, so the turn-on velocity is fast. To optimize the characteristics of the LIMS at high temperatures, we propose a new structure of the LIMS with the optimization of the n+layer, circular light gate, and the new-style edge termination. The diameter of the LIMS is 23 mm. The experiment results show that the leakage current of the proposed LIMS has been decreased from more than 1 mA to 500 μA at 125 °C, the output current of the LIMS is 10.2 kA with a voltage of 4 kV at 85 °C, and the output current of the LIMS is 12.1 kA with a voltage of 4 kV at − 55 °C. Additionally, di/dt is larger than 30 kA/μs.
CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles
Authors: Ohhata Tatsuya , Suzuki Maya , Sakai Satoshi , Ota Kosuke , Yokota Hazuki , Uchida Chiharu , Niida Hiroyuki , Kitagawa Masatoshi
Published: September 2022

Cis-natural antisense transcripts (cis-NATs) are transcribed from the same genomic locus as their partner gene but from the opposite DNA strand and overlap with the partner gene transcript. Here, we developed a simple and convenient program termed CCIVR (comprehensive cis-NATs identifier via RNA-seq data) that comprehensively identifies all kinds of cis-NATs based on genome annotation with expression data obtained from RNA-seq. Using CCIVR with genome databases, we demonstrated total cis-NAT pairs from 11 model organisms. CCIVR analysis with RNA-seq data from parthenogenetic and androgenetic embryonic stem cells identified well-known imprinted cis-NAT pair, KCNQ1/KCNQ1OT1, ensuring the availability of CCIVR. Finally, CCIVR identified cis-NAT pairs that demonstrate inversely correlated expression upon TGFβ stimulation including cis-NATs that functionally repress their partner genes by introducing epigenetic alteration in the promoters of partner genes. Thus, CCIVR facilitates the investigation of structural characteristics and functions of cis-NATs in numerous processes in various species.
Effects of Chlorella extracts on growth of Capsicum annuum L. seedlings
Authors: Tian Shi-Lin , Khan Abid , Zheng Wen-Na , Song Li , Liu Jun-He , Wang Xiao-Qian , Li Li
Published: September 2022

The long-term application of chemical fertilizers has caused to the farmland soil compaction, water pollution, and reduced the quality of vegetable to some extent. So, its become a trend in agriculture to find new bio-fertilizers.Chlorellaextract is rich in amino acids, peptides, nucleic acids, growth hormones, potassium, calcium, magnesium, iron, zinc ions, vitamin E, B1, B2, C, B6, folic acid, free biotin and chlorophyll.Chlorellaextract can promote biological growth, mainly by stimulating the speed of cell division, thereby accelerating the proliferation rate of cells and playing a role in promoting plant growth. WhetherChlorellaextract can be used to improve the growth of pepper (Capsicum annuum), needs to be verified. In current study, a pepper variety 'Chao Tian Jiao' was used as experiment material, by determining the changes of the related characteristics after spraying the seedlings withChlorellaextract, and its effect on growth ofCapsicum annuumplants was investigated. The results showed that theChlorellaextract significantly increased plant height of pepper seedlings (treatment: 32.2 ± 0.3 cm; control: 24.2 ± 0.2 cm), stem diameter (treatment: 0.57 ± 0.02 cm; control: 0.41 ± 0.03 cm) and leaf area (treatment: 189.6 ± 3.2 cm2; control: 145.8 ± 2.5 cm2). Particularly, the pepper seedlings treated withChlorellaextract, developed the root system in better way, significantly increased the chlorophylla, and the activities of SOD, POD and CAT enzymes were also improved significantly. Based on our results, we can speculate that it is possible to improve the growth ofCapsicum annuumseedlings and reduce the application of chemical fertilizers in pepper production by usingChlorellaextract.
Comparative transcriptome profiling and molecular marker development for oil palm fruit color
Authors: Suraninpong Potjamarn , Nuanlaong Sunya
Published: September 2022

Oil palm harvesting is normally determined by fruit exocarp color. To detect expressed sequence tag (EST)-simple sequence repeat (SSR) markers in oil palm hybrid populations, de novo transcriptomic profiling of Nigeria black and Suratthani 1 (Deli × Calabar) plants was performed. More than 46 million high-quality clean reads with a mean length of 1117 bp were generated. Functional annotation and gene ontology (GO) enrichment analysis of differentially expressed genes (DEGs) revealed that the genes were involved in fruit color development and pigment synthesis. Comparison of immature/mature DEGs indicated that nigrescent fruit color was driven by the anthocyanin biosynthesis pathway (ABP); however, the carotenoid biosynthesis pathway (CBP) was involved in the color development of both fruit types. The transcripts of both unique and different genes involved in the ABP and CBP in higher plants were highlighted for further study, especially 3GT, downstream genes in the ABP, and DEARF27 in the CBP. Additionally, SSR primer motifs, namely, 9949, discovered from the DEGs upregulated in the virescent type that encode vacuolar iron transporter (VIT), could separate the nigrescence and virescence traits of Nigeria hybrids. This novel primer has potential to be used as a molecular for further selection in breeding programs especially involving the specific genetic backgrounds described in this study.
An in vitro fibrotic liver lobule model through sequential cell-seeding of HSCs and HepG2 on 3D-printed poly(glycerol sebacate) acrylate scaffolds
Authors: Hsiao Syuan-Ku , Liang Cheng-Wei , Chang Tze-Ling , Sung Yun-Chieh , Chen Yi-Ting , Chen Yunching , Wang Jane
Published: September 2022

We use DLP-AM to create a scaffold and culture cells on it to simulate fibrotic liver tissue.
One-step and highly sensitive quantification of fusion genes with isothermal amplification initiated by a fusion-site anchored stem-loop primer
Authors: Wang Honghong , Wang Shuhui , Wang Hui , Liang Yuanwen , Li Zhengping
Published: September 2022

A one-step method was developed for the fusion gene assay with high sensitivity and specificity by a fusion-site anchored stem-loop primer to initiate isothermal amplification.
Preparation of REE-doped NaY(WO4)2 single crystals for quantitative determination of rare earth elements in REE:NaY(WO4)2 laser crystals by LA-ICP-MS
Authors: Zhang Yu , Sun Yijian , Zhou Jianzong , Yang Jian , Deng Jun , Shao Jianfeng , Zheng Tengfei , Ke Yuqiu , Long Tao
Published: September 2022

An analytical method for quantitative determination of REE concentration in NaY(WO4)2 laser crystals by LA-ICP-MS was proposed using a synthetic REE-doped NaY(WO4)2 single crystal NaYW-500 as an external calibrator.
Synthesis and characterization of a bimetallic americium(iii) pyrithionate coordination complex
Authors: Huffman Zachary K. , Sperling Joseph M. , Windorff Cory J. , Long Brian N. , Cordova Lucas , Ramanantoanina Harry , Celis-Barros Cristian , Albrecht-Schönzart Thomas E.
Published: September 2022

Pyrithione exhibits size-selective dimerization across the f-block. Experimental and computational analysis shows the Am complex contains greater covalency compared to the Nd analog.
Preparation of thioamides from alkyl bromides, nitriles, and hydrogen sulfide through a thio-Ritter-type reaction
Authors: Tang Shi-Zhong , Xiang Kai , Ye Rui , Chen Meng-En , Yu Jian-Chang , He Zhi-Juan , Zhang Fu-Min
Published: September 2022

A thio-Ritter-type reaction is explored for the first time, resulting in structurally diverse thioamides from three available feedstock chemicals.
Site-selective deuteration at the α-position of enals by an amine and bis(phenylsulfonyl)methane co-catalyzed H/D exchange reaction
Authors: Qian Pengfei , Zhang Shilei , Luo Fan , Wang Jiarui , Zhang Xinyu , Liu Xuejun , Chen Xiaodong , Wang Wei , Chen Xiaobei
Published: September 2022

An organocatalyzed reversible Michael reaction has been implemented for the α-position deuteration of enals with a high level of deuterium incorporation.
Efficient dye degradation and THz spectra of {PMo12} based rare earth phosphine oxide complexes
Authors: Hu Cong , Li Ying-Yu , Qiu Qi-Ming , Han Hong-Liang , Gu Chao-Yue , Yang Yu-Ping , Dai Li-Xiong , Jin Qiong-Hua
Published: September 2022

{PMo12} based rare earth phosphine oxide complexes have good adsorption properties for rhodamine B and can degrade methylene blue under UV irradiation.
Organotemplate-free synthesis of Al-rich ZSM-35 and ZSM-22 zeolites with the addition of ZSM-57 zeolite seeds
Authors: Dai Shujie , Tan Yangchun , Yang Yuhan , Zhu Longfeng , Liu Baogang , Du Yanyan , Cao Xuebo
Published: September 2022

An organotemplate-free synthesis of Al-rich ZSM-35 (Si/Al ratio at about 5) and ZSM-22 (Si/Al ratio at about 20) zeolites has been successfully shown with the addition of ZSM-57 zeolite seeds in the absence of organic templates.
Graph-convolutional neural networks for (QM)ML/MM molecular dynamics simulations
Authors: Hofstetter Albert , Böselt Lennard , Riniker Sereina
Published: September 2022

The use of graph convolutional neural networks for mixed (QM)ML/MM molecular dynamics simulations of condensed-phase systems is investigated and benchmarked. We find that a Δ-learning scheme using DFTB as a baseline achieves the best performance.
Process development and policy implications for large scale deployment of solar-driven electrolysis-based renewable methanol production
Authors: Abbas Abiha , Qadeer Kinza , Al-Hinai Amer , Tarar Muhammad Hazim , Qyyum Muhammad Abdul , Al-Muhtaseb Ala'a H. , Abri Rashid Al , Lee Moonyong , Dickson Rofice
Published: September 2022

Using fossil fuels to meet energy demands has led to immense CO2 emissions, resulting in global warming.
Photo-driven metal-free multicomponent reaction between aldehydes, anilines and 4-substituted-DHPs for the synthesis of secondary amines
Authors: Yao Zhen , Yang Ji , Luo Zhenli , Wang Heyu , Zhang Xin , Ye Jianhan , Xu Lijin , Shi Qian
Published: September 2022

A photocatalyst- and transition-metal-free multicomponent reaction of readily available aldehydes, primary amines and 4-alkyl-1,4-dihydropyridines for the synthesis of secondary amines under visible light irradiation has been accomplished.
Synthesis, characterization, biological properties, and molecular docking studies of new phosphoramide-based Ag(i) complexes
Authors: Gholivand Khodayar , Faraghi Mohammad , Tizhoush Samaneh K. , Ahmadi Sara , Yousefian Mostafa , Mohammadpanah Fahimeh , Roe S. Mark
Published: September 2022

The effect of two new synthesized Ag(i) complexes on their biological properties was examined.
One-pot hydrothermal synthesis of high quantum yield orange-emitting carbon quantum dots for sensitive detection of perfluorinated compounds
Authors: Hong Yushuang , Chen Xianping , Zhang Ya , Zhu Yulin , Sun Jingfang , Swihart Mark T. , Tan Kejun , Dong Lin
Published: September 2022

A carbon quantum dot with orange high quantum yield is used to detect PFOS/PFOA in cells.
Sensing and photocatalytic properties of a new 3D Co(ii) coordination polymer based on 1,1′-di(p-carboxybenzyl)-2,2′-biimidazole
Authors: Yang Bo
Published: September 2022

One novel 3D interpenetrated Co(ii) CP acts as multi-functional chemosensors in detection of Fe3+, Cr2O72−, CrO42− and nitrofurantoin and is an effective and stable photocatalyst and displays excellent photo-catalytic properties.
Interfacial engineering of a tri-phase CoFe/CoFeOx/Co–Fe3O4electrocatalyst for promoting the oxygen evolution reaction
Authors: Lei Chao , Chen Jingjuan , Lv Lin , Wan Houzhao , Wang Wenfeng , Zhang Jun , Wang Hanbin , Wang Chundong , Wang Hao
Published: September 2022

A tri-phase interfacial structure of CoFe alloy/CoFe oxide/cobalt-doped iron oxide as a highly efficient and cost-effective oxygen evolution reaction electrocatalyst was elaborately constructed by a one-step chemical bath deposition approach.
A superhydrophobic surface with a synergistic abrasion–corrosion resistance effect prepared by femtosecond laser treatment on an FeMnSiCrNiNb shape memory alloy coating
Authors: Zhang Qi , Xu Peng , Pang Chi , Cui Ke , Yu Chuan , Huang Liang
Published: September 2022

Superhydrophobic coatings prepared by femtosecond laser treatment have favorable mechanical and chemical stability.
Picrotoxane sesquiterpenoids: chemistry, chemo- and bio-syntheses and biological activities
Authors: Shi Qiang-Qiang , Tang Jiang-Jiang , Gao Jin-Ming
Published: September 2022

This review summarizes a total of 132 picrotoxane sesquiterpenoids to date, focusing on their structural diversity, chemo- and bio-syntheses, and biological activities.
Hydrothermal synthesis and controlled growth of group-VIB W metal compound nanostructures from tungsten oxide to tungsten disulphide
Authors: Wang Xue , Yao Cheng-Bao , Wang Li-Yuan , Wang Ze-Miao , Jiang Cai-Hong , Liu Xiao-Jie
Published: September 2022

A new method was developed for the construction of 2D WS2 based on an emerging synthetic route (W-O-S). The photocurrent response of WSxOy with abundant planar defects was improved ascribed to the mismatched lattice spacing between WS2 and WO3 induced strain effect.
Cyclopropylmethyldiphosphates are substrates for sesquiterpene synthases: experimental and theoretical results
Authors: Tran Cong Duc , Dräger Gerald , Struwe Henry Frederik , Siedenberg Lukas , Vasisth Somi , Grunenberg Jörg , Kirschning Andreas
Published: September 2022

Chiral cyclopropylmethyl analogs of farnesyl diphosphate undergo cationic cascade reactions by the sesquiterpene cyclase BcBOT2 yielding new unnatural homosesquiterpenoids. Activation is supported by computational DFT calculation.
Supramolecular self-associating amphiphiles as aqueous pollutant scavengers
Authors: Ellaby Rebecca J. , White Lisa J. , Boles Jessica E. , Ozturk Sena , Hiscock Jennifer R.
Published: September 2022

Combining the principles of supramolecular material formation, host–guest complex formation and the hydrophobic/hydrophilic effect to produce next-generation micropollutant clean-up agents.
Bi-functional water-purification materials derived from natural wood modified TiO2 by photothermal effect and photocatalysis
Authors: Zhang Hui , Wang Xiaohua , Wang Yao , Gu Zhizhi , Chen Liyong
Published: September 2022

A bifunctional water-purification material is designed by surficial carbonization of the semi-spherical end of a natural wood block and loading of P25 on the lateral surfaces of wood domains.
Enhanced transformation of CO2 over microporous Ce-doped Zr metal–organic frameworks
Authors: Bai Juan , Song Ziwei , Liu Lijuan , Zhu Xu , Gao Faming , Chaudhari Raghunath V.
Published: September 2022

Different doping order of Ce/Zr have a significant effect on the morphologies, acid properties as well as on the activities for CO2 conversion of the MOF materials.
The origin of stability and high Co2+/3+ redox utilization for FePO4-coated LiCo0.90Ti0.05PO4/MWCNT nanocomposites for 5 V class lithium ion batteries
Authors: Okita Naohisa , Iwama Etsuro , Takami Yusuke , Abo Shingo , Naoi Wako , Rozier Patrick , Simon Patrice , Reid McMahon Thomas Homer , Naoi Katsuhiko
Published: September 2022

The Fe3+-rich surface on LiCoPO4 prevents from irreversible crystal structure change and electrolyte decomposition, leading to long term cyclability, while Ti4+-substitution contributes to the higher utilization of Co in LiCo0.9Ti0.05PO4 crystals.
Investigating the anti-streptococcal biofilm effect of ssDNA aptamer-silver nanoparticles complex on a titanium-based substrate
Authors: Hosseini Barumand , Behbahani Mandana , Dini Ghasem , Mohabatkar Hassan , Keyhanfar Mehrnaz
Published: September 2022

Silver nanoparticles attached to the specific aptamer forStreptococcus mutans,can significantly remove the biofilm of this bacterium attached to the surface of the titanium implant.
Influence of structure phase transition on the thermoelectric properties of Cu2Se1−xTex liquid-like compounds
Authors: Mac Trung Kien , Ta Thi Thu , Nguyen Huu Tuan , Nguyen Van Du , Pham Thi Lan Huong , Duong Van Thiet , Thanh Tran Dang , Phan Bach Thang , Duong Anh Tuan
Published: September 2022

Copper chalcogenide Cu2(Se,Te) compounds are well known as typical p-type thermoelectric materials with a figure of merit (ZT) that can be optimized by the ratio of Se : Te.
Enhancement of V2O5Li-ion cathode stability by Ni/Co doped Li-borate-based glass
Authors: Siriroj Sumeth , Padchasri Jintara , Montreeuppathum Amorntep , Lomon Jidapa , Chanlek Narong , Poo-arporn Yingyot , Songsiriritthigul Prayoon , Rujirawat Saroj , Kidkhunthod Pinit
Published: September 2022

In this research, we investigate the stability of a Li-ion cathode created by mixing a borate based glass which has been doped with Ni/Co and vanadium pentoxide (V2O5).
Low Au-content CoAu electrodes for environmental applications
Authors: Radinović Kristina , Milikić Jadranka , Balčiūnaitė Aldona , Sukackienė Zita , Bošković Marko , Tamašauskaitė-Tamašiūnaitė Loreta , Šljukić Biljana
Published: September 2022

A low Au-content CoAu electrode prepared by simple electroless deposition outperforms a pure Au electrode for versatile environmental applications: As(iii) sensing in water or as electrodes in direct borohydride-hydrogen peroxide fuel cells.
One-pot strategy to simultaneously prepare dyed, flame retardant and UV-resistant silk fabric based on a safflower yellow derivative
Authors: Yu Dan , Liu Yansong , Ren Yuanlin , Liu Xiaohui , Qu Hongqiang
Published: September 2022

A facile and eco-friendly one-pot technique was used to endow silk fabric with dyeing, flame retardant and ultraviolet (UV)-resistant performance based on a safflower yellow derivative.
Mono- and dinuclear zirconocene(iv) amide complexes for the catalytic dehydropolymerisation of phenylsilane
Authors: Lindenau Kevin , Spannenberg Anke , Reiß Fabian , Beweries Torsten
Published: September 2022

Mono- and dinuclear zirconocene amide complexes were tested as catalysts for the dehydropolymerisation of phenylsilane. The dinuclear complex is surprisingly stable, producing mixtures of polysilanes and cyclic oligomers.
A chemically fueled supramolecular glue for self-healing gels
Authors: Rodon-Fores Jennifer , Würbser Michaela A. , Kretschmer Martin , Rieß Benedikt , Bergmann Alexander M. , Lieleg Oliver , Boekhoven Job
Published: September 2022

Chemically fueled supramolecular materials offer unique properties like the ability to self-heal, yet, mechanisms remain elusive. Here, we demonstrate that chemically fueled gels heal because of a molecular glue-based mechanism.
Motility-induced phase separation of self-propelled soft inertial disks
Authors: De Karmakar Soumen , Ganesh Rajaraman
Published: September 2022

Soft self-propelled inertial disks exhibit MIPS at small inertia, while MIPS vanishes at large inertia.
Capture and detection of Escherichia coli with graphene aerogels
Authors: Shi Chenyang , Tang Yanan , Yang Hanyu , Yang Junfeng , Wu Yuyang , Sun Hang , Yin Shengyan , Wang Guangbin
Published: September 2022

We constructed a biosensor for detecting E. coli using a 3D graphene aerogel as the detection substrate. The detection limit of E. coli can be as low as 10 cfu mL−1.
Ion-imprinted MnO2/CoFe2O4 Janus magnetic micromotors synthesized by a lotus pollen template for highly selective recognition and capture of Pb(ii) ions
Authors: Han Yang , Lyu Yangsai , Xing Ningning , Zhang Xiaolei , Hu Kaiyuan , Luo Hui , Ng Dickon H. L. , Li Jia
Published: September 2022

A new strategy for the design and fabrication of a biomass-based micromotor for highly selective removal of metal contaminating ions from water.