bluuebunny/crossref_metadata_2025 huggingface dataset:
Seasonal and multiannual dynamics of sedentary species populations of hunting interest
Authors:   Institute of Zoology, Republic of Moldova, Savin Anatol , Ciocoi Oleg ,   Institute of Zoology, Republic of Moldova, Scerbliuc Mihail ,   Institute of Zoology, Republic of Moldova, Grosu Gheorghe ,   Institute of Zoology, Republic of Moldova, Nistreanu Victoria ,   Institute of Zoology, Republic of Moldova
Published: October 2021

The aim of the research was to study the number dynamics of the populations of dominant sedentary species of hunting interest as a theoretical context in arguing sustainable measures for the management of economic interest fauna. The studies between 2000-2021 shows that after a period of depression in the populations of sedentary species of hunting interest in 2004-2012 there is an increase from 2016-2017 till present of reproductive stocks in all studied species on average by 95%. The losses in the cold period of the year varied depending on the climatic conditions of the cold period of the year, as well as the age structure at the end of the reproductive period: for the hare between 14% and 30%, with an average of 23%; in grey partridge from 56% to 71% and in pheasant they fluctuate between 48% and 56% of the autumn number, being lower in warm winters (37%). Analyzing the dynamics of annual increases in sedentary small game species in different climatic conditions, it was found that arid conditions during nesting and offspring growth, decrease annual increases by 143% in pheasants, 122% in hares, and only 74% in partridges, which is a species less dependent on aridizations in the vegetative period.
Seasonal and multiannual dynamics of rodent species number under the influence of climate factors and anthropic modifications
Authors:   Institute of Zoology, Republic of Moldova, Sitnic Veaceslav , Nistreanu Victoria ,   Institute of Zoology, Republic of Moldova, Larion Alina ,   Institute of Zoology, Republic of Moldova, Caraman Natalia ,   Institute of Zoology, Republic of Moldova, Caldari Vladislav ,   Institute of Zoology, Republic of Moldova
Published: October 2021

The research was carried out in agricultural experiment stations in the central area of the Republic of Moldova during a period of 35 years. It was determined that cyclic oscillations with an interval of 3-4 years are not typical of Microtus arvalis, as can be seen in other parts of the area. Intense anthropogenic influence determines the type of numerical dynamics. A certain periodicity is observed in the species Mus spicilegus, but during the last 30 years the dynamics has become acyclic. In the populations of the species Apodemus sylvaticus there was a more pronounced periodicity of the oscillation of the herd, once every two years.
The state of Moldavian viper (Vipera Ursinii Moldavica) in the context of the action plan for their conservation (annexed to the Bern convention)
Authors:   Institute of Zoology, Republic of Moldova, Turcan Vladimir
Published: October 2021

Based on the generalization of data from previous publications and own results, regarding the distribution of Meadow Viper (Vipera ursini) in the Dniester - Prut interfluve, the current species state in the context of the Action Plan for conservation, annexed to the Bern Convention, is characterized. The need to complex study of local habitat status and to take measures for their conservation is discussed. The influence of some anthropogenic and climatic factors upon the habitats and the problems of their conservation in the current conditions of agrolandscape are analyzed.
Presarcopenia and chronic cough due to chronic obstructive pulmonary disease successfully treated with nutraceutical supplements and physical exercise
Authors: De Carvalho Jozélio Freire , Lerner Aaron
Published: October 2021

Objective: To describe a patient with presarcopenia and chronic cough secondary to chronic obstructive pulmonary disease (COPD) successfully treated with supplements and physical exercise.Case report: A 75-year-old female patient with a positive past medical history of systemic hypertension, dyslipidemia, heart arrhythmia, and smoking during 20 years evolved with chronic cough due to a chronic obstructive pulmonary disease diagnosed ten years ago. She came to our private clinic due to low weight, low energy. Her weight was 44.8 kg, her height 1.57 m, body mass index of 18.18 kg/m2. Laboratory tests showed SDHEA 76.3, vitamin D of 15.6 ng/ml (nr: > 30 ng/ml), C-reactive protein (CRP) of 55 mg/ml. Computed tomography showed bronchiectasis. She had an skeletal muscle mass index of 5.0 kg/m2 (nr: > 5.5 kg/m2) by DXA. A diagnosis of presarcopenia was determined based on DXA evaluation with low muscle mass but normal gait speed handgrip strength. We suggested to the patient to increase physical exercise and prescribed a supplement formula. After five months, she returned asymptomatic, without cough, marked improvement of fatigue, increased energy levels, and weight increased to 50 kg, BMI of 20.28 kg/m2. Laboratory tests showed SDHEA to 140, vitamin D3 to 64.5 ng/ml, reduced CRP reduced to 5 mg/dl, and amlodipine was excluded due to better blood pressure control. Currently, two years later, the patient continues without cough and has dyspnea only with high efforts, without fatigue, and her weight is 52 kg and BMI 21.1 kg/m2. She also reduced her conventional treatment for COPD, using only a bronchodilator on-demand, without topical corticoids.Conclusions: This case illustrates an interesting case of a patient with presarcopenia and chronic cough, refractory to conventional approach, successfully treated with a combination of nutraceuticals and physical exercises.
Modeling the Exchange Rate Volatility Using the BRICS GARCH-type Models
Authors: Metsileng Lebotsa Daniel , Moroke Ntebogang Dinah , Tsoku Johannes Tshepiso
Published: October 2021

The paper models the performance of GARCH-type models on BRICS exchange rates volatility. The levels of interdependence and dynamic connection among the BRICS financial markets using appropriate univariate time series models were evaluated for the period January 2008 to January 2018. The results revealed the presence of ARCH effects in the BRICS exchange rates. The univariate GARCH models for the BRICS exchange rates were fitted to the data using Student t-distribution. The GARCH (1,1) model found the unconditional volatility for each of the BRICS exchange rates series while EGARCH (1,1) and TGARCH (1,1) models presented the leverage effect. Moreover, the EGARCH (1,1) model illustrated that the asymmetric effects dominate the symmetric effects except for South Africa. The TGARCH (1,1) model on the other hand revealed contrary findings. The paper recommends a study be considered to draw comparison on the different types of GARCH models on the time varying integrated data other than the ones used in the paper.
CLARA Review: K. F. B. Fletcher & Osman Umurhan (eds), 2020: Classical Antiquity in Heavy Metal Music.
Authors: Kiilerich Bente
Published: October 2021

The concepts ‘classical antiquity’ and ‘heavy metal music’ may appear to be worlds apart. Not only are they separated chronologically but each belongs to an entirely different habitus. While the classical is associated with tradition, good taste and harmony, heavy metal is, at least by some, associated with the very opposite: the breaking of tradition, bad taste and disharmony. And yet, as the present book shows, a very large number of heavy metal bands reference antiquity in various ways, including exponents of Thrash Metal, characterised by speed and aggressiveness; Death Metal, characterised by macabre subject matter and growling vocals; Black Metal with related subject matter but less polished style, and other subgenres. Bands from countries ranging from Greece and Italy to Scandinavia incorporate classical quotations in their lyrics or rewrite ancient texts and myths. Some sing in Greek or Latin, others in Italian or English. The titles of songs, such as Hymn to Apollo, Hymn to Zeus, Medusa and so on, further show the classical inspiration.
Modulation of Fibroblast Growth Factor-21 and βklotho Proteins Expression in Type 2 Diabetic Women with Non-alcoholic Fatty Liver Disease Following Endurance and Strength Training
Authors: Astinchap Afsaneh , Monazzami Amirabbas , Fereidoonfara Khadijeh , Rahimi Zohreh , Rahimi Mehrali
Published: October 2021

Background: There is limited research on the effects of physical activity with moderate intensity on βklotho (BKL) and fibroblast growth factor-21 (FGF-21) proteins expression in diabetic patients with non-alcoholic fatty liver disease (NAFLD). Objectives: This study was aimed to determine the effects of eight weeks of endurance and resistance training on BKL and FGF-21 proteins expression in diabetic women with NAFLD. Methods: Forty-five diabetic women (age: 51 ± 8 years, height: 158 ± 2 cm, weight: 75 ± 8 kg) with NAFLD participated. The subjects were randomly divided into three groups, including control (n = 15), endurance training (n = 15), and resistance training (n = 15). The enzyme-linked immunosorbent assay (ELISA) was used to measure BKL and FGF-21 proteins. Two-way ANOVA with repeated measures was applied to determine differences at a significant level of P < 0.05. Results: Eight weeks of endurance and resistance training reduced AST, ALT, and FGF-21 (25, 26, 19% and 13, 16, 13%, respectively) and increased BKL (16% and 18, respectively). However, in the variables of HDL, insulin, AST, ALT, FGF-21, and BKL, a significant difference was observed in the control group (P < 0.05). Also, there was a significant difference between the control and training groups in BKL and FGF21 proteins expression (P < 0.05), but no significant difference was observed between the two training groups (P > 0.05). Conclusions: The results suggest that both moderate-intensity endurance and resistance training can modulate the destructive effects of type 2 diabetes and NAFLD on BKL and FGF-21 proteins expression, and there is no difference between the two training methods.
Is Digital Breast Tomosynthesis Superior to Digital Mammography? A Preclinical Evaluation of Tumor Histopathological Markers Using Digital Breast Tomosynthesis
Authors: Altunkeser Aysegul , Arslan Zeynep Fatma , Eryilmaz Mehmet Ali , Korez Muslu Kazım , Bayramoğlu Zeynep
Published: October 2021

Background: Digital mammography (DM) and digital breast tomosynthesis (DBT) are important radiological modalities, which increase the survival of breast cancer patients. Breast cancer is a morphologically heterogeneous disease with various histopathological parameters and multiple receptors in its biological profile. Objectives: This study aimed to analyze the morphological features of invasive breast cancer on DM and DBT, to investigate the contribution of DBT to DM, to examine the association of DBT findings with pathological molecular subtypes, Bloom-Richardson grade, and Ki-67 index, and to determine the effect of breast parenchyma density on the relationship between DBT findings and hormone receptors. Patients and Methods: A total of 36 patients with malignant lesions were evaluated in this study. According to the American College of Radiology (ACR) classification, the lesion features were divided into subgroups based on DM and DBT, and the findings were compared. The relationships between DBT findings and the hormone receptor status, molecular classification, and Bloom-Richardson grade were also investigated, and the effect of density on these relationships was assessed. Results: The mean age of the patients (n = 36) was 53 years. Based on the comparison of DM and DBT findings, spiculated margins, mass density, architectural distortion, and microcalcifications were significantly more frequent in DBT. Lesions with indistinct margins on DM were observed as mass lesions with spiculated margins on DBT (P < 0.001). Regarding the relationship between DBT findings and hormone receptor status and Ki-67 proliferation index, in progesterone receptor (PR)-positive patients, an irregular tumor shape was more common (89.7%). In PR-negative patients, skin changes and nipple retraction were more frequently seen (P = 0.03 for skin changes, and P = 0.049 for nipple retraction). Regarding the association between Bloom-Richardson grade (BRG) and DBT findings, tumors with a higher grade were more likely to be associated with a high tumor density (P = 0.032). Also, considering the relationship between molecular classification and DBT findings, skin changes and nipple retraction were significantly more frequent in triple-negative masses compared to other subtypes (P = 0.011 for skin changes and P = 0.016 for nipple retraction). Conclusion: DBT is superior to DM, as it reveals the lesion margins, density, and architectural distortion more accurately. The majority of PR-positive tumors were irregular, while most PR-negative cases were round. The mass density also increased as the tumor grade increased. Skin change and nipple retraction were frequently seen in triple-negative tumors compared to other subtypes. Therefore, DBT is a promising diagnostic tool for showing molecular subtypes in dense breasts.
TWENTY YEARS OF "REGIONAL RESEARCH" JOURNAL
Authors: Katrovskiy A.P. , Shuvalov V.E. , Aguirrechu A.A.
Published: October 2021

The article is dedicated to the 20th anniversary of the publication of the scientific journal «Regional Research». The history of the journal’s creation is briefly considered, the main stages of its formation and development are highlighted. An analysis of a number of bibliometric indicators of the journal is given in comparison with other geographical periodicals. Thematic profiles of articles are analyzed. It is noted that at all stages of the journal’s development, the leading place among the directions was occupied by theoretical issues of socio-economic geography, social geography in general, as well as economic geography itself. political and recreational geography. Articles on regional economics and sociology also occupied an important place in the journal. The most cited authors and articles published in the journal over the past 20 years are highlighted.
Unfinished topics and points of growth in my author’s works
Authors: Rodoman B.B.
Published: October 2021

While the main author’s work «Forms of Regionalization» remains unfinished, its pieces can easily be found in different minor papers. «Territorial areals and networks» is open for various researchers to develop different topics from it. «Rodoman-style» cartoids nowadays can easily be created and transformed by means of computer programs. The author’s conclusions on Russia’s cultural landscape are successfully confirmed and developed by V. Kagansky. The works by B. Rodoman in the field of recreation and tourism studies, on personality development during leisure activities, on travel psychology, on the role of fieldwork in young people’s education progress etс. could attract the attention of psychologists, sociologists, health scientists. B. Rodoman considers the terms highlighted through the paper in italics as a points of specific research growth: these concepts can serve as ideas for articles, term papers, theses, or dissertations. The author has compiled a draft dictionary «Basic terms of theoretical geography and rayonistics (zoning studies)».
Current state and development opportunities for closed towns of nuclear industry
Authors: Faikov D.Yu. , Baydarov D.Yu.
Published: October 2021

The article examines the current trends in the development of closed cities of the nuclear industry, the changes taking place in them and the opportunities for development. The relevance of these issues is due to the need to use the scientific and technological potential of cities for the innovative development of the country. Based on foreign experience, it is confirmed that the presence of nuclear industry enterprises on the territory contributes to the creation of innovative ecosystems, makes the territory attractive for business development. In terms of socio-economic development, attention is focused on the movement of the population, the activities of city-forming enterprises and small businesses, the income of the population and local budgets. New trends characteristic of closed cities are identified: strengthening the role of the ROSATOM State Corporation in the management system of nuclear closed cities; diversification of their economy based on the stable operation of the city-forming enterprise and the creation of other high-tech industries with the participation of the ROSATOM State Corporation; the dependence of the population of cities on the state of affairs at the city-forming enterprise; weak interest in the development of small businesses; the appearance of pendulum migration. The further development of closed cities through the expansion of the market of highly qualified labor in them is proposed: the activation of civil research and development; the formation of research networks using unique scientific installations and supercomputer capacities, etc. To attract qualified labor, it is necessary to create comfortable living conditions, which is more likely with the participation of the ROSATOM State Corporation. Some of the proposals are being tested. The results obtained may be of methodological and practical interest not only for closed cities, but also for other single-industry towns, as well as city-forming holdings.
"Child's Play"; Pestering Power Influencing a Parent's Purchasing Behavior in Sri Lanka
Authors: Wasala W. M. A. S. M. , Ravindran N. , Bandara W. A. S. C. , Pratheepan T. , Jayasuriya N. A. , Munasinghe A. A. S. N.
Published: October 2021

Aims: For years, there has been extensive attention in both theoretical and sociological literature regarding a child's ability to exert influence on behavior; in both developed and developing countries, a child's pester power has well recognized by interested parties. Pester Power, often known as the 'nag factor,' refers to adolescent shopping requests directed at their parents.

Methodology: Due to the scarcity of information available on this social phenomenon in Sri Lanka, this paper focuses on conceptualizing a consistent set of factors and determinants discovered after an extensive literature review from a large number of sources and providing a foundation for future research that addresses an empirical and practical gap.

Results: This paper presents a concept model that can be used by Sri Lankan sociological as well as theoretical academicians and researchers to predict the pester power of Sri Lankan youth and adolescents. The model includes demographic, socio-psychographic, and informative factors that could influence the pester power of Sri Lankan youth and adolescents.

Originality: Because this is the first study of its kind in Sri Lanka, marketers and academics will be able to focus their attention on the growing behavior of young consumers in Sri Lanka in relation to the FMCG market by using this consistent set of factors.

Conclusion: Despite the fact that Sri Lanka has a very traditional culture that places a premium on conformity to group norms and social acceptance and thus confirms a collectivistic culture in which children are expected to be subservient, there is this new wave of incredibly energetic, more informed young children who make their own consumer decisions. Empirical evidence on the increasing participation of children in family purchasing and their conversion into active consumers in a rapidly expanding market in south east Asian countries is predominant.
Jaundice Detection System Using Physiological Characteristics
Authors: Layefa Ekereke, , Asagba Prince O.
Published: October 2021

Jaundice is the abnormal accumulation of Bilirubin in the blood, constant checking of their content level in the blood of new born children is vital as going for Anti-natal because its effect is dangerous and irreversible. At the moment, the standard method to determining the concentration of bilirubin in neonates is Laboratory Blood Test (TSB) test and this method can be traumatic for babies due to the constant blood extraction. Our goal in this research is to use hybridized machine learning techniques to develop a jaundice detection system using all the possible physiological characteristics or symptoms. The developed jaundice detection system is capable of detecting the presence of jaundice in neonate non-invasively, it also has a 0.07% standard error coefficient and a Percentage Value of 0.001 when the outcome was compared to TSB of all Test and Validation samples.
Role of CT Angiography in Diagnosis of Reno-Vascular Abnormalities
Authors: Ismail Marei Diaa Mustafa , Dawoud Rasha Mahmoud , Al Ghazaly Ghada Mahmoud , Nooman Darwesh Abdelmonem
Published: October 2021

Background: Reno-vascular disease is a complex disorder, the most common cause of which is RAS. Multi detector computed tomography angiography (MDCTA) plays an important role in assessment of the renal vasculature. Despite conventional angiography is still considered the gold standard in reno-vascular imaging, MDCTA is increasingly used as it is less invasive, easily applicable and available.

Aim of the Study: In our study we aimed to assess the role of CT Angiography in diagnosis of renal vasculature abnormalities.

Patients and Methods: This prospective study was carried out at The Radio-diagnosis and Medical Imaging Department in our institute, conducted on 40 Patients who are clinically suspected to have reno-vascular abnormalities in the period from September 2018 to February 2021. Their ages ranged from 33 to 56 years old.

Results: Based on CTA findings, out of 40 patients, 6 (15%) patients were confirmed to have accessory renal arteries, 6 (15%) patients had renal artery aneurysm, 6 (15%) patients had nutcracker syndrome, 6 (15%) patients had dual venous drainage of both kidneys, two of them showed retro-aortic left renal vein &10 (25%) patients were confirmed to have renal artery stenosis.

Conclusion: CT Angiography with multiplanar reconstruction and three-dimensional display is valuable in studying patients with reno-vascular lesions involving the proximal renal vessels. MDCT angiography is advantageous being a non-invasive technique that can be done on outpatient basis without pre or post-procedure admission, no special post-procedure care and less cost.
The Potential of Differentiation-Related Gene-1 (DRG1) as a Biomarker for Metastasis of Estrogen Receptor-Positive Breast Cancer
Authors: Bor Hillary , Maina Esther N. , Nyambega Benson , Patel Kirtika Tushar , Ochieng’ Olwal Charles , Nalyanya Walter , Gavamukulya Yahaya
Published: October 2021

Introduction: Breast cancer is major burden worldwide and the majority of breast cancers express estrogen receptors (ER) suggesting a high dependence on estrogen hormone. Age is among the major determinants of breast cancer development, however, although Western Kenya is one of the areas with high breast cancer cases, age distribution of ER-positive breast cancer in the sub-region remains largely undocumented. Differentiation-related gene-1 (DRG1) is a metastasis suppressor and thus a potential biomarker for predicting level of metastasis but its potential application in assessing extent of metastasis of ER positive breast cancer has not been fully explored. This study therefore investigated the age distribution and the potential of expression of DRG1 in assessing metastasis of ER positive breast cancer.

Materials and Methods: Breast cancer tumour blocks archived in safe cabins in the histology laboratory section, Moi Teaching and Referral hospital, Eldoret, Kenya were used. Clinico-pathological parameters such as histology grade, tumor size, which are associated with metastatic cancer, were assessed using the archived clinico-pathological reports and/or histological analysis of the tumour blocks. Expression of DRG1 and Ki-67 proteins were determined using immunohistochemistry.

Results: ER positive breast cancer was predominant among women aged 40 and 50 years. No association was observed between immunohistochemical expression of DRG1 and parameters such as histology grade, tumor size or expression of Ki-67 protein expressed DRG1 (p > 0.05).

Conclusion: The findings suggest that expression of DRG1 protein is not associated with parameters that indicate breast cancer metastasis. Thus, DRG1 expression is not a potential biomarker candidate for ER positive breast cancer metastasis. However, since the small sample size was used, further research using larger prospective study is necessary to support the present findings.
Quantum‐Rod On‐Chip LEDs for Display Backlights with Efficacy of 149 lm W−1: A Step toward 200 lm W−1
Authors: Kang Chengbin , Prodanov Maksym F. , Gao Yiyang , Mallem Kumar , Yuan Zhengnan , Vashchenko Valerii V. , Srivastava Abhishek K.
Published: October 2021

Efficient white light‐emitting diodes (LEDs) with an efficacy of 200 lm W−1 are much desirable for lighting and displays. The phosphor‐based LEDs in use today for display applications offer poor color saturation. Intensive efforts have been made to replace the phosphor with quantum‐dot‐based downconverters, but the efficiency and stability of these devices are still in their infancy. Quantum rods (QRs), nanoparticles with an elongated shape, show superior properties such as relatively larger Stokes shifts, polarized emission, and high light out‐coupling efficiency in the solid‐state. However, these QRs usually suffer from poor optical quality for PL wavelengths < 550 nm. Herein, a gradient alloyed CdSe/ZnxCd1−xS/ZnS and CdSe/CdS/ZnS core/shell/shell QR downconverters showing high efficacy LEDs covering a wide color gamut are reported. These QRs show high stability and a precisely tunable photoluminescence peak. The engineered shell thickness suppresses energy transfer and thus maintains the high quantum yield in the solid‐state (81%). These QR‐based LEDs attain an efficacy of 149 lm W−1 (@10mA) and wide color gamut (118% NTSC), which is exceedingly higher than state‐of‐the‐art quantum dots and phosphor‐based on‐chip LEDs.
Vertically Stacked Full Color Quantum Dots Phototransistor Arrays for High‐Resolution and Enhanced Color‐Selective Imaging
Authors: Kim Jaehyun , Jo Chanho , Kim Myung‐Gil , Park Gyeong‐Su , Marks Tobin J. , Facchetti Antonio , Park Sung Kyu
Published: October 2021

Color‐selective multifunctional and multiplexed photodetectors have attracted considerable interest with the increasing demand for color filter‐free optoelectronics which can simultaneously process multispectral signal via minimized system complexity. The low efficiency of color‐filter technology and conventional laterally pixelated photodetector array structures often limit opportunities for widespread realization of high‐density photodetectors. Here, low‐temperature solution‐processed vertically stacked full color quantum dot (QD) phototransistor arrays are developed on plastic substrates for high‐resolution color‐selective photosensor applications. Particularly, the three different‐sized/color (RGB) QDs are vertically stacked and pixelated via direct photopatterning using a unique chelating chalcometallate ligand functioning both as solubilizing component and, after photoexposure, a semiconducting cement creating robust, insoluble, and charge‐efficient QD layers localized in the a‐IGZO transistor region, resulting in efficient wavelength‐dependent photo‐induced charge transfer. Thus, high‐resolution vertically stacked full color QD photodetector arrays are successfully implemented with the density of 5500 devices cm–2 on ultrathin flexible polymeric substrates with highly photosensitive characteristics such as photoresponsivity (1.1 × 104 AW–1) and photodetectivity (1.1 × 1018 Jones) as well as wide dynamic ranges (>150 dB).
High Dynamic Range Smart Window Display by Surface Hydrophilization and Inkjet Printing
Authors: Jin Qihao , Zhang Qiaoshuang , Chen Junchi , Gehring Tim , Eizaguirre Santiago , Huber Robert , Gomard Guillaume , Lemmer Uli , Kling Rainer
Published: October 2021

Mechanoresponsive smart windows have been intensively investigated in recent years as they offer various applications for signage and light management. However, integrating a display functionality into such smart windows remains a challenge since the realization of pixels in these devices is difficult. In addition, mechanoresponsive smart windows with a high dynamic range are rarely demonstrated because they would suffer from complex fabrication processes and high costs. In this work, a novel surface modification process and digital encoding were developed for direct inkjet printing of micro‐etching‐masks on hydrophobic elastomers, and a pixelated haze distribution was realized. Compared to the traditional mechanoresponsive smart windows, which modify the optical performance by applied strain solely, here, a smart window with haze tunability in either static or strain‐applied state is demonstrated. The work enhances the potential of the fabricated smart window to be applied in high dynamic range signage displays.
Predictors of recurrence in early hepatocellular carcinoma patients treated with surgical resection
Authors: Cheng Tzu‐Hsuan , Cheng Yu‐Ming , Wu Chao‐Chuan , Tzeng I‐Shiang , Wang Chia‐Chi
Published: October 2021

Although surgical resection is a curative treatment for early hepatocellular carcinoma (HCC), the incidence of recurrence is still high. The factors associated with HCC recurrence are unclear and deserve investigation. The early HCC patients receiving surgical resection in Taipei Tzu Chi Hospital were enrolled retrospectively. Those with histologically microvascular invasion and largest tumor size >5 cm were excluded. Aggressive recurrence was defined as multiple recurrence (>3), invasion to vessel or extrahepatic metastasis at the first time of recurrence. A total of 125 HCC patients (86 male; mean age 68.74 ± 11.57 year‐old) were included for final analysis. The survival rate was 96%, 91.2%, and 89.6%, at year 1, 3, and 5, respectively. Sixty one (48.8%) patients had HCC recurrence during the median follow‐up duration of 4.4 years. Of them, aggressive recurrence was present in 17 (27.4%) patients. Among patients with recurrent HCC, those with aggressive recurrence had worse survival rates than those without (P = .008). Multifocal tumor was the predictor associated with HCC recurrence using logistic regression analysis; tumor size was associated with earlier recurrence in aggressive recurrence of HCC using stepwise method (P = .042). Although early HCC patients had satisfactory 5‐year survival rates after surgical resection, the incidence of HCC recurrence was still high. The presence of aggressive recurrence had a negative impact on overall survival. Multifocal tumor in histology has higher risk of HCC recurrence, but not the pathologic grade of differentiation. Tumor size was associated with early recurrence in HCC patients with aggressive recurrence.
High‐oxygen‐affinity hemoglobinopathy‐associated erythrocytosis: Clinical outcomes and impact of therapy in 41 cases
Authors: Gangat Naseema , Oliveira Jennifer L. , Hoyer James D. , Patnaik Mrinal M. , Pardanani Animesh , Tefferi Ayalew
Published: October 2021

We describe presenting features, treatment strategies, and follow‐up events involving 41 patients (median age 39 years, range 1–81; 54% males) with high oxygen affinity (HOA) hemoglobinopathy‐associated erythrocytosis, seen at our institution (1973–2020). Thirty‐four (83%) patients carried β‐chain (13 Malmo, 4 Olympia, 3 San Diego, 2 Wood) and 7 (17%) α‐chain (4 Dallas and one each Columbia‐Missouri, Jackson, and Wayne) variants. Median (range) hemoglobin (Hgb)/hematocrit (Hct), serum erythropoietin and p50 were 18 g/dL/52.9% (16–21.9/48–66), 10.4 mIU (4–36.3), and 20 mmHg (12–25), respectively. Family history was documented in 24 patients and history of thrombosis in two (5%). Treatment included phlebotomy in 23 and antiplatelet therapy in 21 patients. At a median follow‐up of 10 years, 23 (56%) patients reported one or more symptoms that were thought to be related to their increased Hct while thrombosis was documented in 10 (24%) patients. Neither Hgb/Hct level nor active phlebotomy showed a significant correlation with either thrombotic or nonthrombotic symptoms (p > .1 in all instances). Among 23 pregnancies recorded, 78% resulted in live births and no fetal loss was attributed to erythrocytosis. The current study does not implicate Hgb/Hct level as a major contributor of morbidity in HOA hemoglobinopathy‐associated erythrocytosis and suggests limited therapeutic value for phlebotomy.
Effect of the Particles Morphology on the Electrochemical Performance of Na3V2(PO4)2F3‐yOy
Authors: Fang Runhe , Olchowka Jacob , Pablos Chloé , Camacho Paula Sanz , Carlier Dany , Croguennec Laurence , Cassaignon Sophie
Published: October 2021

Among all the positive electrode materials explored for Na‐ion batteries, the family of Na3VIII2‐y(VIVO)y(PO4)2F3‐y (NVPFOy) has attracted extensive attention for its high operating voltage and structural stability. In order to promote better performance at high rates, it appears interesting to consider the correlation between NVPFOy’s composition, morphology (size and shape) and electrochemical properties. Here, solvothermal syntheses were considered in order to obtain a series of NVPFOy compounds showing different morphologies (such as nanospheres, flakes, cylindrical aggregates or desert‐roses) by playing on different synthesis parameters like water/ethanol ratio, stoichiometry of the precursors’ mixture, heating rate, and the presence or not of a surfactant. Four compounds presenting different morphology have been fully characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, infrared, NMR and XPS spectroscopies. Their electrochemical properties are studied using electrodes rich in active material in order to better observe the influence of the morphology on the energy storage performance and are compared to those of Na3V2(PO4)2F3 and Na3V2(PO4)2FO2 reference materials obtained by solid‐state synthesis and with shapeless morphology.
Phytochemical Variation within Aerial Parts of Ferula cupularis Populations, an Endangered Medicinal Plant from Iran
Authors: Narimani Rasoul , Tarakemeh Ameneh , Moghaddam Mohammad , Mahmoodi Sourestani Mohammad
Published: October 2021

Ferula cupularis (Boiss.) Spalik et S. R. Downie is an endangered endemic Iranian medicinal plant with occurrence restricted to Fars and Kohkilooyeh Boyerahmad provinces, Iran. F. cupularis is cited for strong antibacterial activity, usages in foodstuffs preservation, and has long been used by local peoples for ulcer treatment. In this research, the aerial parts of F. cupularis wild populations were collected from three natural habitats: Eqlid‐Kaftar (FC1), Kakan (FC2), and Sepidan‐Komohr (FC3), to assess phytochemical diversity and antioxidant activity. The quantity of essential oil (EO) ranged remarkably from 0.42 to 0.72 % v/w among the populations. Results obtained from the EO analysis by GC‐FID and GC/MS detected up to 56 compounds. α‐Pinene (21.65–31.53 %), sabinene (4.74–11.39 %), phellandrene (1.78–5.1 %), δ‐3‐carene (1.85–7.18 %), limonene (4.12–7.45 %), (Z)‐β‐ocimene (9.08–17.64 %), and elemicin (0.23–5.74 %) were the major compounds of EOs varied significantly among the populations. Moreover, total phenol content (250.54 to 387.45 mg gallic acid/100 g dry weight (DW)) and flavonoids (34.38 to 41.12 mg quercetin/100 g DW) of methanolic extracts varied substantially among the populations. Antioxidant activities of F. cupularis EOs and extracts were assessed by DPPH (2,2,1‐diphenyl‐1‐picrylhydrazyl) radical scavenging method. EOs exhibited EC50 values ranging from 8.88 to 9.67 μg mL−1 and the EC50 values for the extract ranged from 941.36 to 1335.96 μg mL−1 within the populations. Results demonstrated significantly different levels of antioxidant capacities among the studied populations. Monitoring the data, the population collected from Eqlid‐Kaftar (FC1) was selected as the most potent population concerning the highest EO content and antioxidant activity level. The obtained data provided new insights for an initial source of breeding plans and ultimately massive production for food and pharmaceutical industries.
Chemical Preintercalation of H2V3O8‐reduced Graphene Oxide Composites for Improved Na‐ and Li‐ion Battery Cathodes
Authors: Söllinger Daniela , Berger Thomas , Redhammer Günther J. , Schoiber Jürgen , Pokrant Simone
Published: October 2021

Due to a growing demand for sustainable electrical energy storage alternatives to Li‐ion batteries (LIBs), Na‐ion batteries (SIBs) are of great interest because of the abundance of Na+. By modifying layered H2V3O8 by preintercalation and composite formation, improved electrochemical properties were obtained in LIBs. In analogy, a scalable soft chemistry synthesis is developed, to chemically presodiate H2V3O8 for the first time, in addition to a composite formation reaction with reduced graphene oxide (rGO). Crystal structure and morphology of all compounds are determined and their electrochemical properties as cathode are evaluated with respect to both Na+ and Li+ intercalation. The combination of preintercalation and composite formation leads to excellent initial capacities of 96 mAh ⋅ g−1 for SIBs and 371 mAh ⋅ g−1 for LIBs (58 % and 48 % higher than unmodified H2V3O8) at a practical current density of 100 mA ⋅ g−1, demonstrating that H2V3O8 is a promising cathode material for SIBs and LIBs.
Porous 3D Architecture of Carbon‐Encapsulated Fe3O4Nanospheres Anchored on Networks of Carbon Nanotubes as Anodes for Advanced Lithium‐Ion Batteries
Authors: Yuan Yapeng , Kong Zhen , Qiao Lei , Xu Zhengguan , Wang Zongyu , Teng Xinghe , Dong Yuhao , Liu Xuehua , Fu Aiping , Li Yanhui , Li Hongliang
Published: October 2021

The application of Fe3O4as anode material for lithium‐ion batteries is hindered by the capacity fade owing to its enormous volume expansion and the inherent low conductivity. Herein, carbon‐encapsulated Fe3O4nanospheres anchored on carbon nanotubes (Fe3O4/CNTs@C) have been successfully fabricated. The obtained Fe3O4/CNTs@C composites show that numerous Fe3O4nanospheres are held and connected by the CNT network, forming a composite of porous three‐dimensional structure. The unique structure improves the conductivity and structural stability of the Fe3O4/CNTs@C composite. The encapsulation with carbon enhances the contact between Fe3O4nanospheres and carbon nanotubes and shortens the ion‐transport path. As a result, the Fe3O4/CNTs@C delivers a high capacity of 612 mA h g−1at 1 A g−1, even after 200 cycles, and shows a superior rate performance of 523 mA h g−1at 5 A g−1. This work provides a preparation strategy that could be easily applied to other functional materials for energy storage and/or catalysis.
Herstellung und Charakterisierung von Polysulfon‐Membranen für die Gastrennung
Authors: Kluge Steven , Weiß Michael
Published: October 2021

Polysulfon (PSU) ist ein geeignetes Material für die industrielle Gastrennung. In der vorliegenden Studie konnten mit speziellen Gießlösungen über den Trocken/Nass‐Phaseninversionsprozess PSU‐Flachmembranen mit einer porösen Stützstruktur und einer trennaktiven Deckschicht im Mikrometerbereich in einem Schritt hergestellt werden. Durch Variation der Zusammensetzung der Gießlösung und des Fällungsmediums konnte die Ausprägung der einzelnen PSU‐Schichten variiert werden. Zum Nachweis der Schichtstrukturen der PSU‐Flachmembranen wurden rasterelektronenmikroskopische Aufnahmen angefertigt. Die Gastrenneigenschaften wurden anhand von Permeabilitäten und idealen Trennfaktoren durch Gaspermeationsmessungen ermittelt.
Optimization of Gas Scrubbing in the Calcination of Struvite
Authors: Thumeyer Lucas , Bertau Martin , Fröhlich Peter
Published: October 2021

During the calcination of magnesium ammonium phosphate hexahydrate (struvite) in the process of recycling to obtain phosphoric acid, ammonia is released in addition to water and carbon dioxide. With a gas scrubber, e.g., in the form of a bubble column reactor, ammonia can be recovered as a usable valuable material. With water as an inexpensive and effective absorbent, almost complete absorption (92 %) of the ammonia from the exhaust air can be achieved.
The prevalence and clinical associations of ultrasound measures of congestion in patients at risk of developing heart failure
Authors: Cuthbert Joseph J. , Pellicori Pierpaolo , Flockton Rachel , Kallvikbacka‐Bennett Anna , Khan Javed , Rigby Alan S. , Girerd Nicolas , Zannad Faiez , Cleland John G.F. , Clark Andrew L.
Published: October 2021

Aims

Congestion is a cardinal feature of untreated heart failure (HF) and might be detected by ultrasound (US) before overt clinical signs appear.

Methods and results

We investigated the prevalence and clinical associations of subclinical congestion in 238 patients with at least one clinical risk factor for HF (diabetes, ischaemic heart disease, or hypertension) using three US variables: (i) inferior vena cava (IVC) diameter; (ii) jugular vein distensibility (JVD) ratio (the ratio of the jugular vein diameter during the Valsalva manoeuvre to that at rest); (iii) the number of B‐lines from a 28‐point lung US. US congestion was defined as IVC diameter > 2.0 cm, JVD ratio < 4.0 or B‐lines count > 14. The prevalence of subclinical congestion (defined as at least one positive US marker of congestion) was 30% (13% by IVC diameter, 9% by JVD ratio and 13% by B‐line quantification). Compared to patients with no congestion on US, those with at least one marker had larger left atria and higher plasma concentrations of natriuretic peptides. Patients with raised plasma N‐terminal pro‐B‐type natriuretic peptide/B‐type natriuretic peptide had a lower JVD ratio (7.69 vs. 8.80; P = 0.05) and more often had at least one lung B‐line (74% vs. 63%; P = 0.05). However, plasma natriuretic peptide concentrations were more closely related to left atrial volume than other US measures of congestion.

Conclusions

Subclinical evidence of congestion by US is common in patients with clinical risk factors for HF. Whether these measurements provide additional value for predicting the development of HF and its prevention deserves consideration.
Power of moment‐based normality tests: Empirical analysis on Indian stock market index
Authors: Shaik Muneer , Gulhane Rutvik Digambar
Published: October 2021

In this paper, we study the power of moment‐based normality tests which include Jarque Bera (JB) test and D′Agostino and Pearson (DP) omnibus tests. Power comparison were obtained via Monte Carlo simulation of sample data generated from four alternative distributions like Uniform, Logistic, Student t and Gamma distribution. Our simulation results show that for Uniform distribution, DP test has better power compared to JB test. For Logistic, Student t and Gamma distributions, we find JB normality test to be powerful compared to DP test. We further apply the moment‐based normality tests empirically on the Indian stock market indices (NSE Nifty 50 and BSE Sensex) for different frequencies (daily, weekly, monthly and quarterly) during the period from 2010 to 2020. We find that daily returns of Indian stock indices are non‐normal whereas weekly, monthly and quarterly returns are normally distributed.
Comparative performance of annual wellness visits between pharmacists and physicians at primary care clinics
Authors: Moffatt Evelyn Kisakye , Wargo Ryan , Johnson Christa , Kawaguchi‐Suzuki Marina
Published: October 2021

Introduction

Annual wellness visits (AWVs) can help close care gaps, defined as differences between guideline‐recommended practice and actual care. The purpose of this study was to compare the performance of AWVs conducted by pharmacists and physicians toward care gap closure for the prevention and treatment of cardiovascular disease and osteoporosis.

Methods

A retrospective chart review was conducted to evaluate interventions made during AWVs by pharmacists and physicians at primary care clinics. The variables of interest were (a) use of aspirin, statins, angiotensin‐converting enzyme inhibitors/angiotensin receptor II blockers, bisphosphonates, calcium/vitamin D, and proton pump inhibitors, and (b) need for dual energy x‐ray absorptiometry (DEXA) scans. The primary outcome was the rate of care gap closure examined between pharmacists' and physicians' panels.

Results

Among 416 AWVs completed by pharmacists, 233 care gaps were identified, and 120 care gaps were closed. Similarly, among 169 AWVs completed by physicians, 103 care gaps were identified, and 27 gaps were closed. The rates of care gap closure were 0.29 ± 0.43 for physicians and 0.53 ± 0.48 for pharmacists (mean ± SD). The number of care gaps significantly improved between pre‐ and post‐AWVs for both groups (P < .01). The noninferiority test showed that the rates were noninferior for pharmacists compared with physicians (95% confidence interval: 0.12‐0.36). Overall, the most notable care gaps identified were (a) missing DEXA screenings, (b) inappropriate statin therapy, and (c) inappropriate calcium/vitamin D therapy. Reasons for not closing gaps were (a) declined drug therapy, (b) prior intolerance to medication, and (c) not completed DEXA scans. AWVs also corrected medication list inaccuracies and increased vaccination.

Conclusion

This study showed that both pharmacists and physicians can utilize AWVs to close care gaps for the prevention and treatment of cardiovascular disease and osteoporosis, and the performance of pharmacists was noninferior to that of physicians.
Polyphenolic composition and antioxidant potential of underutilized Himalayan wild edible berries by high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry
Authors: Sendri Nitisha , Bhandari Pamita
Published: October 2021

The Himalayan wild berries Myrica esculenta, Duchesnea indica, Prunus cerasoides, and Berberis lycium were studied for the first time for polyphenolic compositions using high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry. The chemical analysis of extracts resulted in the identification of 69 polyphenols, including 11 anthocyanins, 28 phenolic acids, 19 flavanoids, 10 ellagitannins, and 1 dihydrochalcone. The caffeoylquinic acids, quercetin, kaempferol, and cyanidin are the common moieties in studied wild berries. In addition, seven phenolic compounds, that is, gallic acid, vanillic acid, caffeic acid, rutin, ferulic acid, quercetin, and myricetin were quantified. Among anthocyanins, cyanidin‐3‐O‐glucoside was the majorly quantified anthocyanin that ranged from 2.52 to 6.18% followed by delphinidin‐3‐O‐glucoside (0.6%–5.53%). The samples were assessed for total phenolics, total anthocyanin content, and antioxidant potential. The results showed that M. esculenta and B. lycium had the highest total phenolic and anthocyanin content and exhibited promising antioxidant activity with IC50 of 32.100 ± 0.42 and 48.44 ± 0.46 μg/mL, respectively. Principal component analysis was able to clearly differentiate between four underutilized Himalayan wild edible berries. The wide variability of polyphenolic constituents supports the consumption of these berries not only to achieve the nutrient requirements among local people but also as promising sources of antioxidants for the food industry.