bluuebunny/crossref_metadata_2025 huggingface dataset:
The Rasch Analysis of Students’ Characteristics in Physics Concept Understanding Improvement through Challenge-Based Learning
Authors: Bohori Muhammad , Liliawati Winny , Suwarma Irma Rahma , Ringo Sariaman Siringo
Published: December 2022

Concept mastery is one of the main goals in the learning process. This study aimed to analyze the improvement of students’ physics concept mastery by implementing challenge-based learning with Edmodo-assisted learning. This study used mixed methods with an embedded experimental model research design. The research sample was 10th-grade students in a public vocational school’s food crops and horticulture agribusiness program. Data analysis employed the Rasch model with the help of ministeps software version 4.1.1. The results of this study indicate a significant increase in students’ conceptual mastery of +3.44 logit. The average logit value of students’ abilities is higher than the average logit value of the item difficulty level. Students’ physics concept mastery can be improved through the challenge-based learning model assisted by Edmodo.
Evaluation of shooting sports achievement development program at PB PERBAKIN
Authors: Ariesta Tiana Wanda , Pelana Ramdan , Setiakarnawijaya Yasep
Published: December 2022

The purpose of research is evaluation of the implementation of the national sports achievement development program for shooting sports in PB PERBAKIN using the CIPP evaluation model (Contexs, Input, Process, Product). The sampling technique was purposive sampling, so the sample in this study is 39 people. Collecting data using observation, interviews, questionnaires, and documentation. The data analysis technique used in this research is quantitative and qualitative descriptive analysis. The results showed that the overall results of the evaluation of the coaching program for improving national sports achievement in the airsoft sport in PB. PERBAKIN has been running well with a score of 67,92. In terms of context, it has gone well with a nikai of 69,40. In terms of input it has been going well with a value of 70,21. In terms of the process has been going well with a value of 67,35. In terms of the product, in general, the achievements achieved are quite good, but the achievement is not maximized so that a score of 56,75 is obtained even though it is not in line with expectations but in this evaluation there are good things, namely the support and enthusiasm of parents for athletes is very good.
Do hurricanes or freezing events regulate the sustainability of subtropical mangroves on the Gulf of Mexico coast?
Authors: Cohen Marcelo , Yao Qiang , de Souza Adriana V. , Liu Kam-biu , Nunes Sergio , Rodrigues Erika , Pessenda Luiz C.R. , Culligan Nicholas
Published: December 2022

Global warming has caused poleward mangrove expansion, but extreme climatic events have significantly impacted the mangroves along their boreal limits. This study aimed to determine which natural hazard is more important in limiting the sustainability and survival of subtropical black mangroves—hurricanes or freezing events? Satellite and drone images indicated Hurricanes Zeta and Ida (2020 – 2021) caused only minor damage to Avicennia trees (~5%, 6.32 ha) compared with the extensive mortality caused by the winter freeze of Dec/2017- Jan/2018 (~ 89%, 110 ha) at Port Fourchon, Louisiana. However, mangroves impacted by winter freezes had a faster recovery (~1 year), while the losses of mangrove areas by hurricanes are longer-lasting. This finding is novel and important because it implies that subtropical mangroves have low resistance but high resilience to winter freezes, while these forests present high resistance but low resilience to hurricanes. Overwash processes driven by hurricanes are the primary threat to mangroves at Port Fourchon due to the high rate of beach barrier retreat, which causes the burial of the back-barrier wetlands. In 2022 a new beach renourishment project is currently underway, resulting in shoreline progradation. This human intervention is essential to guarantee the stability of the beach barrier and slow down the increased losses of mangrove and salt marsh areas caused by sea level rise and extreme events. The mangrove at Port Fourchon is a microcosm of the general ecological balance of mangroves growing along their northern distribution limit. Thus, our findings apply to the coastal wetlands on the entire northern Gulf of Mexico.
Effects of a Multicomponent Lipid Emulsion on Brain Volumes in Extremely Low Birth Weight Infants
Authors: Costa Simonetta , Cocca Carmen , D’Apolito Gabriella , De Gisi Antonietta , Fattore Simona , Tataranno Maria Luisa , Benders Manon , Pastorino Roberta , Colosimo Cesare , Vento Giovanni
Published: December 2022

Purpose
During the early weeks of life optimization of nutrition in extremely preterm infants presents a critical opportunity to attenuate the adverse neurologic consequences of prematurity and potentially improve neurodevelopmental outcome. We hypothesized that the use of multicomponent lipid emulsion (MLE) in PN would be related to larger volume of the cerebellum on brain magnetic resonance at term of equivalent age (TEA) in extremely low birthweight (ELBW) infants.
Methods
We analyzed the brain Magnetic Resonance Imaging (MRI) at TEA of a cohort of preterm infants with gestational age (GA) ≤28 weeks and/or birthweight (BW) <1000 grams randomly assigned in our previous trial to receive a Multicomponent lipid emulsion (MLE) or Soybean-based lipid emulsion (SLE). The primary outcome of the study was the cerebellar volume (CeV) valued on MRI acquired at TEA. Secondary outcomes included total brain volume (TBV), Supratentorial Volume (SuV), Brainstem Volume (BsV) and Cerebellar volume corrected for TBV evaluated on MRI acquired at TEA.
Results
MRIs at TEA of 34 infants were then analyzed: 17 in the MLE group and17 in the SLE group. The postmenstrual age (PMA) at which MRIs were performed were comparable between the two study groups. The CeV, as well as the PMA-corrected CeV, were significantly higher in the MLE group than in the SLE group. No difference was found among the other brain volumes considered.
Conclusion
Our results suggest that the use of MLE in PN could promote CeV growth in ELBW infants, valued with MRI at TEA.
Postpartum depression and associated factors in Afar Region, Northeast Ethiopia
Authors: Mulugeta Yisahak , Adem Ahmed , Ibrahim Ibrahim , Getachew Gebru , Ahmed Kedir Yimam
Published: December 2022

Background: Understanding the magnitude and associated factors of postpartum depression (PPD) in the pastoral and hot region of the Afar Region is essential to identify current gains and future gaps for accelerating efforts in reducing the burden of PPD. No previously published study has examined the prevalence and associated factors of PPD in pastoral communities in Ethiopia (including the Afar Region). Accordingly, we investigated the prevalence and associated factors of PPD among postpartum women in the Afar Region, Northeast Ethiopia.
Methods: An institution-based cross-sectional study was conducted from June to July 2021. Postpartum women who visited the Expanded Program of Immunisation (EPI) units of health facilities were included. We used the Edinburgh Postnatal Depression Scale (EPDS) to measure PPD. Multivariable logistic regression modelling was applied to investigate associations between sociodemographic, obstetric and health service, and psychosocial factors with PPD.
Results∶ The overall prevalence of PPD was 37.4% with a 95% confidence interval (CI) from 32.0% to 43.0%. Postpartum women with a family history of mental illness (adjusted odds ratio [AOR] = 2.34; 95% CI: 1.24, 4.41), who had trouble in infant feeding (AOR = 4.26; 95% CI: 2.32, 7.83), and those who experienced intimate partner violence (AOR = 3.09; 95% CI: 1.58, 6.04) were positively associated with PPD. Postpartum women who attained high school education were less likely to experience PPD compared to those who did not attain formal schooling (AOR = 0.31; 95% CI: 0.12, 0.82).
Conclusion: Our findings showed that the prevalence of PPD is higher than the national and global averages. Findings from the study warranted the need for a PPD screening program and targeted interventions for pastoral postpartum women with risk factors.
Empirical Research on Tax Havens
Authors: Dias Paulo , Miranda Ana
Published: December 2022

The main goal of this study is to analyse and characterize the empirical research produced in the time period between the years 2008 and 2018 on tax havens. In order to achieve this goal, an analysis of the selected sample was performed in order to characterize the investigators and the content of their articles. The results of the study show that collective authorship is predominant, being that articles with two authors are more frequent, and the majority of the researchers in the sample contributed with only one article. Geographically, the continent with the highest contribution was Europe and analysing by country the United States of America held the highlighted role. Regarding the universities, Australian universities presented more affiliated authors. With regards to the content of the articles, the thirty six articles from the sample were published in twenty seven different journals, being that 2015 was the year with the most publications. Other than the topic tax havens, tax avoidance and tax evasion where the most addressed themes by the researchers.
Subject classification codes: H26; F23; M41
Disaster tweet classification: A majority voting approach using machine learning algorithms
Authors: Krishna Dasari Siva , Gorla Srinivas , D Prasad Reddy P V G
Published: December 2022

Nowadays, People share their opinions through social media. This information may be informative or non-informative. To filtering the informative information from the social media plays a challenging issue. Nevertheless, in social media especially when a disaster been occurs the peoples will interact more on that particular disaster event. They share their opinion through some textual information such as tweets or posts. In this work, we are proposing a generalized approach for categorizing the informative and non-informative on twitter media. We collected the seven natural disaster events from the crisisNLP. These datasets are different disaster events which contains the people’s opinions on that specific event. We preprocess the information which converts the tweet information into machine understandable vectors. These vectors been processed by the different machine learning algorithms. We consider the individual performance of each ML algorithm on different disaster datasets upon chosen the best five algorithms for voting techniques. We tested the performance with matrices such as accuracy, precision, recall and f1-score. We compared our results with existing models in which our proposed model performed better than other existing state of art models.
Suppressors of cytokine signalling (SOCS1) inhibits neuroinflammation by regulating TLR4 and ROS in BV2 cells
Authors: Wang Weiwei , Hu Jinxia , Hao Qi , Zhang Tao , Wang Miao , Zhang Lijie , Xiang Jie
Published: December 2022

Objective
The Suppressors of cytokine signalling(SOCS) proteins are physiological suppressors of cytokine signaling which have been identified as a negative feedback loop to weaken cytokine signaling. However, the underlying molecular mechanisms is unknown. This study was to investigate the role of SOCS1 in the oxygen-glucose deprivation and reoxygenation (OGDR) or LPS induced inflammation in microglia cell line BV-2 cells.
Materials and methods
BV-2 microglial cells were used to construct inflammation model. A SOCS1 over-expression plasmid was constructed, and the SOCS1 deficient cells were generated by utilizing the CRISPR/CAS9 system. BV-2 microglial cells were pretreated with over-expression plasmid or SOCS1 CRISPR plasmid before OGDR and LPS stimulation. The effect of SOCS1 on proinflammatory cytokines, toll-like receptor4 (TLR4), and reactive oxygen species (ROS) were evaluated.
Results
We found that SOCS1 increased in OGDR or LPS treated BV-2 microglial cells in vitro. SOCS1 over-expression significantly reduced the production of proinflammatory cytokines including tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-6, and CRISPR/CAS9-mediated SOCS1 knockout reversed this effect. Also we determined that SOCS1 over-expression reduced the level of reactive oxygen species (ROS) while the absence of SOCS1 increased the production of ROS after OGDR or LPS stimulated inflammation. Furthermore, we found that OGDR and LPS induced the expression of toll-like receptor 4 (TLR4) in BV2 cells. Nevertheless, SOCS1 over-expression attenuated the expression of TLR4, while knockdown of SOCS1 upregulated TLR4.
Conclusions
Our study indicated that SOCS1 played a protective role under inflammatory conditions in OGDR or LPS treated BV-2 cells through regulating ROS and TLR4. These data demonstrated that SOCS1 served as a potential therapeutic target to alleviate inflammation after ischemic stroke.
EHR-Safe: Generating High-Fidelity and Privacy-Preserving Synthetic Electronic Health Records
Authors: Yoon Jinsung , Mizrahi Michel , Ghalaty Nahid , Jarvinen Thomas , Ravi Ashwin , Brune Peter , Kong Fanyu , Anderson Dave , Lee George , Meir Arie , Bandukwala Farhana , Kanal Elli , Arik Sercan , Pfister Tomas
Published: December 2022

Privacy concerns often arise as the key bottleneck for the sharing of data between consumers and data holders, particularly for sensitive data such as Electronic Health Records (EHR). This impedes the application of data analytics and ML-based innovations with tremendous potential. One promising approach to avoid such privacy concerns is to instead use synthetic data. We propose a novel generative modeling framework, EHR-Safe, for generating highly realistic and privacy-preserving synthetic EHR data. EHR-Safe is based on a two-stage model that consists of sequential encoder-decoder networks and generative adversarial networks. Our innovations focus on the key challenging aspects of real-world EHR data: the data are heterogeneous, consisting of numerical and categorical features with distinct characteristics; they contain time-varying features with highly-varying sequence lengths; and the features are often highly sparse. Under numerous evaluations, we demonstrate that the fidelity of EHR-Safe is very high, i.e. it has almost-identical properties with real data while yielding almost-ideal performance in practical privacy metrics.
NUP98::NSD1 and FLT3-ITD collaborate to generate acute myeloid leukemia
Authors: Aplan Peter , Matsukawa Toshihiro , yin  , Nigam Nupur , Negi Vijay , Li Li , Small Donald , Zhu Yuelin , Walker Robert , Meltzer Paul
Published: December 2022

Nucleoporin 98 (NUP98) fusion genes and FMS-related tyrosine kinase 3 gene (FLT3) internal tandem duplications (ITDs) are recurrent events in patients with acute myeloid leukemia (AML). The NUP98::NSD1 fusion, which joins the amino terminal portion of NUP98 to the carboxy terminal portion of NSD1 (Nuclear receptor-binding SET Domain 1) is the most common NUP98 fusion in human AML. AML patients with NUP98::NSD1 fusion typically also have a FLT3-ITD mutation, and the combination of these two oncoproteins results in a poor prognosis. We established NUP98::NSD1 transgenic mice as an in vivo model. Although the penetrance of AML in mice that expressed a NUP98::NSD1 fusion was low, the incidence of AML increased dramatically when accompanied by a FLT3-ITD mutation. Gene expression profiling showed that murine NUP98::NSD1/FLT3-ITD AML were myelomonocytic, with an expression profile similar to human NUP98::NSD1 AML. Also similar to human AML, the wild type Flt3 allele was frequently lost in murine NUP98::NSD1/FLT3-ITD AML. Whole exome sequencing of NUP98::NSD1/FLT3-ITD AML revealed few Tier 1 somatic mutations, suggesting that the NUP98::NSD1 fusion protein and FLT3-ITD may be sufficient for leukemogenesis. This study demonstrates that the NUP98::NSD1 fusion gene is leukemogenic in vivo, and provides a model for pre-clinical studies.
Quality-of-life endpoints in women of childbearing age with hidradenitis suppurativa: a tertiary-care-centre-based study
Authors: Tsentemeidou Aikaterini , Sotiriou Elena , Bakirtzi Katerina , Papadimitriou Ilias , Chatzi-Sotiriou Themis , Panagopoulou Angeliki , Kougkas Nikolaos , Lallas Aimilios , Vakirlis Efstratios
Published: December 2022

Hidradenitis suppurativa (HS) principally affects women of childbearing age, who face gender-specific challenges, with lower life-quality than men. To investigate various quality-of-life endpoints in women of childbearing age with HS. A cross-sectional questionnaire-based study was performed at a university dermatology department. Eighteen yes/no and one open-ended questions explored impact of HS on social life, sexual life, family planning, working life and healthcare-backed support. Ninety-six women were included. Most women (80.8%) carry a stigma because of HS, which also affects their choice of clothes and social relationships. Sexual impairment affects 73.1% of women. One third of women wants less or no children because of HS, 67.7% worry about its impact on pregnancy, birth and the postpartum, and 84.6% worry about the impact of HS treatment on fertility and their babies’ health. Almost 43% fear losing their job because of HS, 34.4% are discriminated against at work and 33.3% state HS has hindered their career. Most women are not adequately informed about their disease or available support groups/material and 41.7% have not received good enough care through pregnancy/postpartum. Life-quality endpoints should be meticulously screened in women. Multidisciplinary-led treatment should be offered during pregnancy and the postpartum.
Applying radial basis function neural network for comprehending properties of each cluster of fuzzy c-means in coordinates analysis (case study in Iran)
Authors: Shahnavehsi Reza
Published: December 2022

For notifying the properties of special area with similar properties, clustering analysis is really helpful, and neural network methods have ability to create usable model. One of the best ways for clustering is fuzzy c-means, and fuzzy c-means by the basis of fuzzy method divides data set to different clusters. Radial basis function is neural network which is utilizing spread and this algorithm’s layers like input layer, hidden layer and output layer for creating effective neural network. This paper is introduced a novel method, in this method data points (longitude and latitude of main cities of Iran) by using fuzzy c-mean algorithm is divided to different clusters then for each cluster RBF neural networks is defined separately, and this method is FCM-RBF. The outcome of FCM-RBF build neural network for each cluster separately, and result of this study shows that radial basis function neural network can enhance the quality of analysis of outcomes of this kind of clustering and by applying this algorithms different clusters with same properties is calculated and create neural network separately for each cluster, and three clusters are proposed for this algorithms and data points of cluster2 and cluster3 has acceptable rate of adaptability with RBF neural network but data points of cluster1 can’t adapt themselves with neural network perfectly, and validity of outcomes of this clustering increase by using radial basis function neural network. In this algorithm data points of each clusters can separately analyze which is cause better comprehending of study area.
Do It Yourself: how can we use Almonds and Almond Shells in cosmetics? Easy body exfoliant and facial mask
Authors: Gonçalves Sara , Gaivão Isabel
Published: December 2022

Avoiding the potentially dangerous chemicals found in many of today's commercially made beauty products is a good reason for making our own cosmetic products. Almonds have been used for centuries in cosmetics. They enhance the glow and fairness of the skin. Almonds are easily obtained in the Trás-os-Montes area (Portugal), and suggestions on how to use them in cosmetics should be made. This study presents a method for using almonds and almond shells as a cosmetic product that can be reproduced domestically.
Biochronological ages for South African Plio-Pleistocene hominins
Authors: Thackeray Francis , Dykes Susan
Published: December 2022

The ages of South African Plio-Pleistocene hominin fossils (Australopithecus africanus, A. prometheus and early Homo) are in question. Cosmogenic dates for Australopithecus from Sterkfontein Member 4 published by Granger et al (2022) range between 3.4 and 3.7 Ma. By contrast, biochronological age estimates for this genus, as published by Frost et al (2022) from cercopithecid primates, range between 2 – 2.7 Ma. In this study a biochronological approach based on hominin teeth is adopted, initially using an equation whereby the ratio of mesiodistal (MD) and buccolingual (BL) diameters of East African hominin lower first molars (M1) can be related to radiometric dates for a sample of specimens attributed to A. afarensis, H. habilis, H. rudolfensis and H. erectus, ranging in age from 0.9 to 3.8 Ma. The equation is applied to MD/BL ratios for South African hominins. On the basis of that equation, the mean estimated age for 20 molars attributed to Australopithecus from Sterkfontein is 2.67 ± 0.53 Ma, ranging widely between 1.81 and 3.50 Ma. Results obtained by both Granger et al (2022) and by Frost et al (2022) fall closely within that range. The age estimate for the holotype of A. africanus from Taung is 2.57 Ma, while the dates for MLD 2 and MLD 40 (attributed to A. prometheus or A. africanus) from Makapansgat are 3.06 and 2.99 Ma respectively. Sterkfontein hominins controversially attributed to early Homo (Stw 151 and Sts 9) have ages of 1.80 and 2.01 Ma respectively.
Attosecond-Angstrom free-electron-laser towards the cold beam limit
Authors: Habib A. F. , Manahan G.G. , Scherkl P. , Heinemann T. , Sutherland A. , Altuiri R. , Alotaibi B. M. , Litos M. , Cary J. , Raubenheimer T. , Hemsing E. , Hogan M. , Rosenzweig J.B. , Williams P. H. , McNeil B. W. J. , Hidding B.
Published: December 2022

Electron beam quality is paramount for X-ray pulse production in free-electron-lasers (FELs). State-of-the-art linear accelerators (linacs) can deliver multi-GeV electron beams with sufficient quality for hard X-ray-FELs, albeit requiring km-scale setups, whereas plasma-based accelerators can produce multi-GeV electron beams on metre-scale distances, and begin to reach beam qualities sufficient for EUV FELs.
We show, that electron beams from plasma photocathodes many orders of magnitude brighter than state-of-the-art can be generated in plasma wakefieldaccelerators (PWFA), and then extracted, captured, transported and injected into undulators without quality loss. These ultrabright, sub-femtosecond electron beams can drive hard X-FELs near the cold beam limit to generate coherent X-ray pulses of attosecond-Angstrom class, reaching saturation after only 10 metres of undulator.
This plasma-X-FEL opens pathways for novel photon science capabilities, such as unperturbed observation of electronic motion inside atoms at their natural time and length scale, and towards higher photon energies.
Development and Characterization of Expressed Sequence-tagged Simple Sequence Repeat Markers for Denphal-type Dendrobium Cultivars and Transferability to Dendrobium Species
Authors: Yi Shuangshuang , Huang Mingzhong , Yang Guangsui , Niu Junhai , Lu Shunjiao , Yin Junmei , Zhang Zhiqun
Published: December 2022

Denphal-type Dendrobium is the most popular orchid for cut flower and potted plant trade. To improve commercial traits, many novel cultivars have been produced through hybridization by commercial breeders. However, the genetic relationship of most cultivars is unclear, thus hindering the progress of Denphal-type Dendrobium breeding programs. Therefore, the development of molecular markers is encouraged to identify different cultivars. In this study, based on the transcriptome database of the Denphal-type Dendrobium ‘Red Bull’, the polymorphisms expressed sequence tag-derived simple sequence repeat (EST-SSR) were developed from 100 pairs EST-SSRs that were randomly selected from the EST-SSR database. The genetic relationship of 42 Denphal-type Dendrobium cultivars was analyzed according to the developed EST-SSRs. Then, the transferability of EST-SSRs was analyzed by performing a relationship analysis of 40 Dendrobium species. The results showed that a total of 5174 potential EST-SSR markers were identified with 4486 unigene sequences, and 5289 primer pairs were successfully designed. Of the selected 100 pairs of EST-SSRs, a total of 86 pairs produced the expected polymerase chain reaction products of the primary screening, 58 pairs produced the expected fragment size, and 20 pairs showed polymorphisms. Furthermore, the dendrogram of 42 cultivars showed that at a genetic distance of 0.15, the cultivars collected were grouped into five clusters of three major clusters and two minor clusters; all these clusters had the same characters of each cluster. The transferability analysis showed that 18 of the 20 EST-SSR markers among the 40 Dendrobium species were polymorphic. Overall, this study developed EST-SSR markers and will be valuable to facilitating genetic diversity in Denphal-type Dendrobium cultivars and Dendrobium species.
Nanostructural domains in martian apatites that record primary subsolidus exsolution of halogens: Insights into nakhlite petrogenesis
Authors: Martínez Marina , Shearer Charles K. , Brearley Adrian J.
Published: December 2022

The microstructures of selected F-, Cl-, and OH-bearing martian apatite grains, two in Northwest Africa (NWA) 998 (cumulus apatites, embedded in pyroxene) and a set of four in Nakhla (intercumulus apatites), were studied by focused ion beam–transmission electron microscopy (FIB-TEM) techniques. Our results show that the nanostructure of martian apatite is characterized by a domain structure at the 5–10 nm scale defined by undulous lattice fringes and slight differences in contrast, indicative of localized elastic strain within the lattices and misorientations in the crystal. The domain structure records a primary post-magmatic signature formed during initial subsolidus cooling (T <800 °C), in which halogens clustered by phase separation (exsolution), but overall preserved continuity in the crystalline structure. Northwest Africa 998 apatites, with average Cl/F ratios of 1.26 and 2.11, show higher undulosity of the lattice fringes and more differences in contrast than Nakhla apatites (average Cl/F = 4.23), suggesting that when Cl/F is close to 1, there is more strain in the structure. Vacancies likely played a key role stabilizing these ternary apatites that otherwise would be immiscible. Apatites in Nakhla show larger variations in halogen and rare-earth element (REE) contents within and between grains that are only a few micrometers apart, consistent with growth under disequilibrium conditions and crystallization in open systems. Nakhla apatite preserves chemical zonation, where F, REEs, Si, and Fe are higher in the core and Cl increases toward the outer layers of the crystal. There is no evidence of subsolidus ionic diffusion or post-magmatic fluid interactions that affected bulk apatite compositions in NWA 998 or Nakhla. The observed zonation is consistent with crystallization from a late-stage melt that became Cl-enriched, and assimilation of volatile-rich crustal sediments is the most plausible mechanism for the observed zonation. This work has broader implications for interpreting the chemistry of apatite in other planetary systems.
EFFECTS OF MARKETING PROMOTION ON FARM PRODUCE IN CROSS RIVER STATE
Authors:   Department Of Marketing, Ebonyi State University, Abakaliki., Ekahe-Joseph Abua Ntamu
Published: December 2022

Increase in sales is the heartbeat of every marketer. This is achieved very much by promotion. This study evaluated the effect of marketing promotion on farm product in Cross River State . Objectives were raised for the study which led to the raising of research questions. Organically, the following hypotheses were formulated : awareness creation has no positive impact on farm products in Cross River State social media makes no positive impact on farm products in Cross River State branded promotional gifts has no correlation with sales of farm products in Cross River State and customer loyalty makes no positive impact on farm products in Cross River State . Difference in mean statistic was used to test the hypotheses which led to the following findings : awareness creation has positive impact on farm products in Cross River State social media makes positive impact on farm products in Cross River State branded promotional gifts has correlation with sales of farm products in Cross River State and customer loyalty makes positive impact on farm products in Cross River State. It was concluded that farmers can use promotion to push up demand for their farm products. It was recommended that the farmer should maximize awareness creation on his farm products since it makes positive impact on farm products social media should be well utilized by the farmer since it makes positive impact on farm products branded promotional gifts should be well considered by the farmer since it correlates with sales of farm products and customer loyalty should be always exploited by the farmer since it makes positive impact on farm products.
SUBDERMAL PLEXUS AS A GUIDE FOR SKIN FLAP THICKNESS IN MODIFIED RADICAL MASTECTOMY IN BREAST CANCER
Authors:   Assistant Professor, Department of Surgery, Zoram Medical College Hospital, Falkawn, Mizoram., Lalchhandama R. , Vanlalhlua C. ,   Associate Professor, Department of Surgery, Zoram Medical College Hospital, Falkawn, Mizoram.
Published: December 2022

Introduction: Breast cancer is the most common invasive cancer to affect women in the world and is the second highest cause of cancer death in women after lung cancer. Different surgical options are available for treating breast cancer but Modified Radical Mastectomy is still the most common surgery performed worldwide for breast cancer and has the lowest incidence of loco-regional recurrence. Aim: The aim of this study to find out the role of sub-dermal plexus as a guide to achieve optimum skin flap thickness during modified radical mastectomy for breast cancer. Materialsandmethods: This prospective study was conducted in the Department of Surgery and Pathology, Zoram Medical College Hospital, Falkawn, Mizoram. A total of 40 patients with Breast carcinoma for which Modified Radical Mastectomy were included in this study. Results: All the patients were observed for skin flap necrosis. The overall incidence of Flap necrosis was 0% as observed on POD1, POD2, POD4 and POD6. Although after POD14, there were a total of 5 patients who had surgical site infection with wound gaping for whom debridement, dressings and secondary suturing were done. Conclusion: we concluded that there is minimal chance of skin flap necrosis and minimal chance of leaving behind breast tissue using subdermal plexus of vein as a guide for optimum skin flap thickness in modified radical mastectomy in patients with breast cancer.
Does the perception of government integrity differ across regions? A comparative study between several sub-Saharan and Asian countries
Authors: Aden Kadir
Published: December 2022

The study seeks to examine if the perception of government integrity differs or is similar across regions, mainly when some factors have been included in the assessment. The paper focuses on six sub-Saharan (Mali, Nigeria, Cameroon, Zambia, Angola, and South Africa) and Asian countries (Japan, South Korea, China, Malaysia, Thailand, and Singapore) from 2016 to 2020. A nested pooled OLS regression model was employed. Government integrity was used as a predicted variable, whereas economic freedom and one government indicator (absence of violence) were independent variables. The obtained results yielded some differentiation for both regions. For instance, Sub-Saharan countries reacted positively to government spending, while the opposite reaction was detected in Asian countries. In terms of similarities, inflation has a negative impact on government integrity for both regions. In contrast, trade freedom and addressing unemployment by including it in the government’s agenda are seen as a proxy of good governance. The findings also show that labor freedom is only perceived negatively in sub-Saharan countries. On the other hand, FDI inflows show a positive effect for both regions, but it is only significant for sub-Saharan countries. Similarly, the absence of violence contributes positively to the degree of government integrity perception. This study is one of the first to conduct a comparative analysis between two regions in the context of determining factors that affect government integrity perceptions. Overall, the paper provides good insights for policymakers and official representatives to enhance the level of the state’s economic freedom.
Ethnic Resource in the Construction of Regional Identity by the President of the Republic of Tatarstan in Social Networks
Authors: Mikhaleva Albina
Published: December 2022

Social networks are an essential part of various political processes. They help to build mental models and control official public discourse. The article features the ethnic resource as part of the regional identity constructed by the President of the Republic of Tatarstan on his Instagram. The analysis relied on both the subjective and regional presentation, as well as visual and content contexts. The author analyzed Instagram posts published in 2020-2022, as well as media publications on the issue of ethno-cultural positioning. The analysis included qualitative and quantitative content analyses, as well as static and comparative methods. Rustam Minnikhanov’s Instagram proved to be an informative source that made it possible to identify the priority attitudes to the local ethno-cultural issues in the official discourse. The ethno-cultural resource was especially important for the personal self-presentation. The regional positioning maintained a multi-ethnic Tatarstan identity, where the ethnic resource played an important role, which does not mean the real parity of the corresponding ethno-cultural traditions. The author believes that the ethno-cultural resource will continue to determine the socio-political climate in the region.
Assessing the Digital Maturity of HR Management as Part of Digital Transition
Authors: Lapikov Andrey
Published: December 2022

Human resource management is a key process that affects digital transformation because any transformation is inspired, provided, and executed by personnel. The digital maturity of personnel management is a hot topic for all industries that requires scientific understanding. Digital business transformation relies on new approaches in competence development, new organizational structure, new corporate ideology, etc. A timely analysis of business processes is necessary to form a trajectory of transformations. The purpose of the study was to determine the state of human resource management as a business process and identify its elements that require development for prospective digital transformation. The author employed the systematic approach, as well as various methods of digital maturity assessment to interpret the maturity indicators of personnel management in various industries. The digital transformation of human resource management proved to require top management involvement, new digital competencies, digital services, and products, a single data source for decision-making, and a continuous chain of innovations.
Large-Scale Transport Projects and Regional Economic Growth
Authors: Pyataev Maksim
Published: December 2022

Infrastructure projects contribute to the development of regional transport and economy. This article features the impact of large-scale transport projects on economic growth. The author determined the relationship between investments in major transport projects and the consequences of their implementation. The study relied on such methods as generalization, classification, comparison, description, and mathematical statistics. One and the same large-scale transport projects are admired as beneficial and criticized as inefficient. Traditional views on investment usually provide only negative coverage. Therefore, large-scale transport projects need to be analyzed from different perspectives that meet regional and national interests. The original hypothesis was the dependence between the gross regional product and the fixed assets of transport organizations in the regions. The comprehensive analysis of this relationship in various regions of the Russian Federation proved the dependence between these parameters. A poor infrastructure was a deterrent to the regional economic growth. The author believes that the critique of large-scale infrastructure projects is unfounded. In fact, they contribute to the regional economic development, primarily in developing countries that are undergoing structural economic changes.
Industrial Tourism Potential of an Old Industrial Region
Authors: Aparina Natal'ya , Kavkaeva Natal'ya
Published: December 2022

The current crisis in the domestic economy and the tightened international sanctions exacerbate the issue of finding industries that can boost regional development. Tourism is an alternative to traditional industries in an old industrial region. It can rebrand the territory and make an industrial region generate tourist flows. Each old industrial region of the Russian Federation has its own strategies for the development of the tourism industry. Usually, they aim at a total rebranding of their territory, thus rejecting their traditional industrial image. As a result, strategic documents often ignore the touristic potential of old industrial regions. However, industrial tourism can encourage the development of the tourism industry in such regions. The present article introduces some possibilities for the development of industrial tourism in the Kemerovo Region based on consumer preferences. The research methodology relied on an integrated approach to the local touristic resources and involved 160 students of the Kemerovo State University who were asked to assess the attractiveness of the local industrial tourism. The authors used the cluster approach to describe some potential directions for industrial tourism in the Kemerovo Region.
Regional Problems of Digital Economic Development
Authors: Belchik Tatyana , Frolov Nikita
Published: December 2022

The article introduces an analysis of the digital economic development in the Kemerovo Region. The study was based on statistical data obtained from The Russian Federal Statistics Service, as well as on the expert opinion of local managers. The e-commerce of the local population and organizations remains low. All social strata lack digital skills, and IT specialists are scarce. The local digital economy depends on raw materials and suffers from youth out-migration. The National Digital Economy Project presupposes developing digital skills in all age groups and industries. The authors believe that the local authorities fail to use many opportunities provided by information and communication technologies: even some of the interviewees seemed unable to comprehend the importance of digital transformation. The article presents the dynamic indicators that describe the development of the digital economy in the Kemerovo Region, the Siberian Federal District, and the Russian Federation.
Industrial Tourism as a New Trend in the Development of Siberian Single-Industry Towns
Authors: Ivanova Marina , Matyunin Vladimir
Published: December 2022

Most Russian regions possess a certain degree of tourist and recreational potential but fail to produce any kind of tourism industry, or it develops chaotically, with no regard to the tourist infrastructure. This is especially relevant for numerous single-industry cities and towns in the Siberian Federal District, where travel industry could diversify the local economy and improve the socio-economic status. The authors believe that industrial tourism can help Siberian single-industry towns to overcome the crisis scenario. This research covered the regions of Altai, Kemerovo, Khakassia, and Irkutsk. The sampling relied on official tourist portals and independent sites where single-industry towns promote themselves as tourist and recreational places. The authors used scientific, theoretical, and quantitative methods to analyze the tourist potential of these territories and study the foreign experience of large enterprises in industrial tourism. The article contains a review of relevant scientific publications and introduces some recommendations on the development of industrial tourism in single-industry towns of the Siberian Federal District, which can be extrapolated to other single-industry urban settlements in Russia.
Financial Management of Risks: Multi-Agency Investment Projects
Authors: Vyzhitovich Aleksandr
Published: December 2022

Effective risk management needs new approaches to risk analysis, especially in multi-agent investment projects. The article focuses on cluster projects currently active in the Novosibirsk Region, as well as on specific financial risks that occur between interacting organizations of various ownership forms. The author studied the assessment methodology for risks that develop as a result of unreliable or incomplete information, violation of state subsidies, their repayment, etc. The analysis of Novosibirsk clusters involved the Kontur. Focus software. The proposed methods included defining key parameters of the control model, procedures for input reliability check, a diagnostic methodology for project members, and integrating the effectiveness of the cluster control system. These approaches and methods can be included in a new integrated approach to the mesolevel risk management of multi-agent cluster projects as part of state and corporate control.
RELATIONSHIP AMONG THE LEVELS OF DOPAMINE, THYROID AND ANTISPERMAL ANTIBODIES IN POPULATIONS OF THE EUROPEAN AND ASIAN NORTH
Authors:   Laverov Federal Center for Integrated Arctic Research of the Ural Branch of Russian Academy of Sciences, Archangelsk, Tipisova Е.V. , Alikina V.A. ,   Laverov Federal Center for Integrated Arctic Research of the Ural Branch of Russian Academy of Sciences, Archangelsk, Molodovskaya I.N. ,   Laverov Federal Center for Integrated Arctic Research of the Ural Branch of Russian Academy of Sciences, Archangelsk, Elfimova A.E. ,   Laverov Federal Center for Integrated Arctic Research of the Ural Branch of Russian Academy of Sciences, Archangelsk, Zyabisheva V.N. ,   Laverov Federal Center for Integrated Arctic Research of the Ural Branch of Russian Academy of Sciences, Archangelsk
Published: December 2022

Autoantibodies to thyroglobulin (AntiTGs) and thyroperoxydase (AntiTPs) define in many ways the thyroid activity, whereas antispermal antibodies (ASABs) control the reproductive system. Most of these antibodies belong to immunoglobulin class G; dopamine is able to control the processes of antibody production. The aim was to demonstrate differences in contents of and relationship among dopamine, thyroid and thyroid and ASABs, thyroglobulin (TG) in male and female populations on the European and Asian North of the Russian Federation. We investigated 336 essentially healthy males and females at the age of 22 to 44 and 45 to 59 years respectively. Blood serum was analyzed for autoantibodies and plasma - for dopamine. High frequency of dopamine above the upper norm margin was observed in males; dopamine concentration was undetectable in females. Increased dopamine and decreased AntiTG combined with increased TG and ASABs in the Asian North population may suggest that dopamine inhibits AbtoTG synthesis and, therefore, stimulates the thyroid activity. In females, deviations in typically increased antithyroid antibodies and typically decreased TG were more often and could be connected with a higher occurrence of undetectable levels of dopamine that inhibits the autoantibodies production and contributes in autoimmunization. In addition to the dopamine and ASAB synergy effect on spermatozoids, negative correlations between their levels in the Asian and European North populations may also suggest an inhibitive effect of dopamine on ASAB. The dopamine effect on the autoimmune effect could be a building block for preventing the risk of autoimmune pathology among people living in the extreme North environment.
DETERMINATION OF THE EFFECT OF DIRECTED LIGHTING BY BLUE LIGHT-EMITTING DIODES ON GROWTH OF TAP ROOTS OF ARABIDOPSIS THALIANA SEEDLINGS DURING SLOW 2D-CLINOSTAT ROTATION
Authors:   Institute for Biomedical Problems of Russian Academy of Sciences, Moscow, Belyak A.M. , Shilovich А.А. ,   Institute of Gene Biology of Russian Academy of Sciences, Moscow, Krivobok A.S. ,   Institute for Biomedical Problems of Russian Academy of Sciences, Moscow, Nikitin V.B. ,   Institute for Biomedical Problems of Russian Academy of Sciences, Moscow, Bibikova T.N. ,   Institute for Biomedical Problems of Russian Academy of Sciences, Moscow
Published: December 2022

The paper presents the results of experiments with 48-hour horizontal and vertical clinostatting of 5-day old Arabidopsis thaliana seedlings in 2 types of lighting, i.e. white light (4000 cd) and lateral blue light (450 nm). The experiments were performed in a clinostat designed to install Petri dishes with juvenile Arabidopsis thaliana in the horizontal and rotate it about the horizontal axis at a speed of 1 rev/min. Angular bend of the main root (MR) was measured as it elongated. It was demonstrated that, on the average, vertical clinostating in white light caused a more significant MR departure from the apical-basis axis than the horizontal clinostating. The proposed space experiments with Arabidopsis seedlings and laboratory controls will require extensive preliminary studies of the effects of specific light spectra and directions, and crop orientation. In blue light, there was no difference in the MR departure due to the seedlings placement in the clinostat; however, more than 75 % of the seedlings tended to bend away from the light source. Directed blue lighting in a 2D-clinostat can be an approach to root system orientation based on the negative phototropism.
The Effectiveness of Impact of Physical Activity on the Thinking Indicators of School Children
Authors: Polevoy Georgiy Georgievich
Published: December 2022

Purpose:

The purpose of this study is to determine the influence of physical activity in physical education classes on the thinking indicators of schoolchildren.

Methods:

This was a cross-sectional study conducted in a secondary school number 60 in Kirov (Russia), attended by ninth graders aged 15-16 years (141 schoolchildren). The main method of research was the test “Cross out an extra word”, which determined the level of development of students' thinking. The test was used before and after the physical education lesson 1 time per month for 5 months. Statistical analysis used: The student's T-criterion was used in the study.

Results:

The children who did not exercise, but completed the test, were able to only slightly improve their performance. This trend is observed every month. The indicators improved on average from 2.1% to 4.3% (p>0.05).

The situation is different for children who were engaged in physical education lessons. In each of the five months, the test indicators improved significantly, on average, from 14.2% to 18.8% (p<0.05).

Conclusion:

Physical education likely has a beneficial effect on the thinking of schoolchildren. This study will serve as an additional motivation for children to engage in physical activities, since physical exercises contribute not only to the development of physical qualities, but also to the development of schoolchildren's thinking.