bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantitative evaluation of therapy options for relapsed/refractory diffuse large B-cell lymphoma
Authors: Li Ting , Hou Mengyuan , Zha Sijie , Cheng Qingqing , Zheng Qingshan , Li Lujin , Yu Jiesen
Published: May 2022

Background
The prognosis of patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) is still poor, and their treatment options are limited, which highlights the need for new treatments. This study aimed to quantitatively evaluate the efficacy, safety, and related factors of various therapeutic options for patients with r/r DLBCL to provide necessary quantitative information for clinical practice.
Methods
A literature search was conducted using public databases. The parametric survival function was used to describe the time course of overall survival (OS) and progression-free survival (PFS) in patients with r/r DLBCL receiving various treatment regimens. A random-effects model in a single-arm meta-analysis was used to analyze the objective response rate (ORR) and grade 3–5 adverse event rates based on various treatment regimens.
Results
A total of 58 studies including 3124 subjects were included. Combination therapy had a significant benefit in terms of OS, PFS, and ORR compared with monotherapy. ORR and PFS were significantly improved in the treatment regimen, including chemotherapy, but OS did not improve, and grade 3–5 adverse events significantly increased. In terms of treatment strategy, the efficacy of chemotherapy combined with immunotherapy sequential autologous stem cell transplantation (ASCT), immunotherapy combined with immunotherapy, chemotherapy sequential ASCT, chemotherapy combined with immunotherapy, and chemotherapy combined with two types of immunotherapy is better. Specific to each treatment regimen, R-inotuzumab ozogamicin, R-BEAM + ASCT, R-ESHAP-L, iodine-131 tositumomab + BEAM + ASCT, and chemotherapy + CAR-T had better efficacy, with median OS of 48.2, 34.2, 27.8, 25.8, and 25 months, respectively. Moreover, there was a strong correlation between the 6-month PFS and 2-year OS in the combination therapy.
Conclusions
Combination therapy and chemotherapy can significantly improve the efficacy of r/r DLBCL treatment. The 6-month PFS can be used as a surrogate endpoint for the 2-year OS. This study provides the necessary quantitative information for clinical practice and clinical trial design of r/r DLBCL.
The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration
Authors: Perry Alistair , Hughes Laura , Adams Natalie , Naessens Michelle , Murley Alexander , Rouse Matthew , Street Duncan , Jones P Simon , Cope Thomas , Kocagoncu Ece , Rowe James
Published: May 2022

There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including symptomatic treatments. One approach is for experimental medicine, coupling neurophysiological studies of the mechanisms of disease with pharmacological interventions aimed at restoring neurochemical deficits. Here we consider the role of glutamatergic deficits and their potential as targets for treatment. We performed a double-blind placebo-controlled crossover pharmaco-magnetoencephalography study in 20 people with symptomatic frontotemporal lobar degeneration (10 behavioral variant frontotemporal dementia, 10 progressive supranuclear palsy) and 20 healthy age- and gender- matched controls. Both magnetoencephalography sessions recorded a roving auditory oddball paradigm: on placebo or following 10mg memantine, an uncompetitive NMDA-receptor antagonist. Ultrahigh-field magnetic resonance spectroscopy confirmed lower concentrations of GABA in the right inferior frontal gyrus of people with frontotemporal lobar degeneration. There was no overall effect of memantine on the magnitude of the mismatch negativity response in right frontotemporal cortex in patients, or controls. However, the change in right auditory cortex response to memantine (vs. placebo) in patients correlated with individuals’ prefrontal GABA concentration. There was no moderating effect of glutamate concentration, or cortical atrophy. This proof-of-concept study demonstrates the potential for baseline-dependency in pharmacological restoration of neurotransmitter deficits, to influence cognitive neurophysiology in neurodegenerative disease. With changes to multiple neurotransmitters in frontotemporal lobar degeneration, we suggest that individuals’ balance of excitation and inhibition may determine drug efficacy, with implications for drug selection and patient stratification in future clinical trials.
Application of allograft and absorbable screw in the reconstruction of massive bone defect following resection of giant osteochondroma: a retrospective study
Authors: Ma Zhihao , Yang Qiang , Liu Xinyu , Li Zhenfeng
Published: May 2022

Background: This study aims to introduce a reconstruction method that applicating allograft and absorbable screw to repair large bone defect caused by resection of giant osteochondroma.Methods: A retrospective study of a series of patients who underwent the resection of giant osteochondroma reconstructed by allograft and absorbable screw was conducted from February 2020 to September 2021. Their demographic data, location site, osteotomy length and pertinent operative details were recorded. Reconstruction modality allograft were elaborated. In the follow-up, radiographic images were utilized to determine bone union, and the Musculoskeletal Tumor Society (MSTS) score was used to evaluate the postoperative limb function.Results: A total of 7 patients were included, including 3 males and 4 females with an average age of 16.6±6.5 years. Among them, 3 cases of tumors occurred in humerus and 4 cases in femur. The average follow-up time was 11.3±3.0 months. The average area of bone graft was 25.9±8.3 cm2. No complications such as infection, nonunion and allograft bone fracture were found during the follow-up period. At six months after operation, the average MSTS score was 26.4±1.6 with acceptable postoperative function. Conclusions: The cooperative application of absorbable screw fixation and allograft including mixed cortical bone and cancellous bone，which yielded satisfactory functional outcomes and acceptable postoperative complications, is an effective reconstruction method for massive bone defect after the resection of giant osteochondroma.
Dual-Energy CT Iodine Map in Predicting the Efficacy of Neoadjuvant Chemotherapy for Hypopharyngeal Carcinoma: A Preliminary Study
Authors: Wei Xianfeng , Cao Rui , Li Han , Long Miaomiao , Sun Peipei , Zheng Yongzhe , Li Li , Yin Jianzhong
Published: May 2022

Background: Induction chemotherapy has become one of the important means for advanced hypopharyngeal carcinoma. so far, there is no effective index to predict the curative effect.To investigate the value of normalized iodine map of dual-energy computed tomography (CT) in predicting the efficacy of neoadjuvant chemotherapy for hypopharyngeal carcinoma. Methods: A total of 54 hypopharyngeal carcinoma patients who underwent two courses of TPF induction chemotherapy were recruited in this study. 3 cases had a complete response (CR), 36 cases had a partial response (PR), 11 cases had stable disease (SD), and 4 cases had a progressive disease (PD) after the chemotherapy. All patients underwent a dual-source CT scan before chemotherapy and rescanned after chemotherapy. The normalized iodine-related attenuation (NIRA) of the mean of maximum slice and most enhanced region of lesion at arterial and parenchymal phase were measured: NIRAmean-A, NIRAmax-A, NIRAmean-P, and NIRAmax-P, respectively. Correlation analysis was conducted between different metrics of NIRA and the diameter change rate of lesions, and the curative effect was evaluated based on the receiver operating characteristic (ROC) curve.Results: There were a significant correlation between NIRAmean-A, NIRAmax-A, NIRAmean-P, NIRAmax-P and the change rate of lesion’s maximum diameter (ΔD%) (all P<0.01). The NIRAmax-A, NIRAmean-P, NIRAmax-P had significant differences between CR, PR, SD, PD groups, but NIRAmean-A did not reach a significant difference. All NIRAmean-A, NIRAmax-A, NIRAmean-P, NIRAmax-P had significant differences between effective (CR+PR) and ineffective (SD+PD) groups. The ROC analysis revealed that NIRAmean-P had the largest AUC and prediction efficacy (AUC=0.809). Conclusion: Dual-energy CT normalized iodine map could predict the efficacy of neoadjuvant chemotherapy and provides imaging evidence to assist in treatment decisions for hypopharyngeal carcinoma patients.
Rubiarbonol B induces RIPK1-dependent necroptosis via NOX1-derived ROS production
Authors: Byun Hee Sun , Park Kyeong Ah , Ju Eunjin , Sohn Kyung-Cheol , Jung Chan Seok , Hong Jang Hee , Ro Hyunju , Lee Hoi Young , Quan Khong Trong , Park InWha , Na MinKyun , Hur Gang Min
Published: May 2022

The activation of receptor-interacting protein kinase 1 (RIPK1) by death-inducing signaling complex (DISC) formation is essential for triggering the necroptotic mode of cell death under apoptosis-deficient conditions. Thus, targeting the induction of necroptosis by modulating RIPK1 activity could be an effective strategy to bypass apoptosis resistance in certain types of cancer. In this study, we screened a series of arborinane triterpenoids purified from Rubia philippinesis, and identified rubiarbonol B (Ru-B) as a potent DISC-mediated caspase-8 activator. Ru-B elicited both the apoptotic and necroptotic modes of cell death, depending on the cellular expression of RIPK3. In RIPK3-expressing human colorectal cancer (CRC) cells, and the pharmacological or genetic inhibition of caspase-8 was sufficient to cause a switch in cell death mode from apoptosis to necroptosis following Ru-B treatment by necrosome formation which accompanied by the upregulation of RIPK1 phosphorylation. Conversely, Ru-B-induced cell death was almost completely abrogated by RIPK1 deficiency. The enhanced RIPK1 phosphorylation and necroptosis triggered by Ru-B treatment occurred independently of tumor necrosis factor receptor signaling, and was mediated by the production of reactive oxygen species via NADPH oxidase 1 in CRC cells. Thus, we propose Ru-B as a novel anticancer agent that enhances the cytotoxic potential of RIPK1, prompting the further development of Ru-B as a necroptosis-targeting compound in apoptosis-resistant CRC.
A Mathematical Model for Quantification of Pulmonary and Intrapulmonary Arteriovenous Anastomoses Blood Flow
Authors: Vanni Rosalba
Published: May 2022

Objectives: To develop a model for the calculation of pulmonary blood flow (Qp) and blood flow through intrapulmonary arteriovenous anastomoses (QIPAVA) under multiple physiological conditions.

Methods: A mathematical model was developed into which many experimental physiological parameters were input. Data were obtained simultaneously from arterial blood gases, metabolic measures, and non-invasive measures of cardiac output (Qt) , in young and healthy men.

Results: It was possible to precisely calculate Qp and QIPAVA at rest, and at moderate (50% of VO2max ) and heavy exercise ( 90% of VO2max ), in both normoxia (FIO2= 0.2093) and acute hypoxia (FIO2 = 0.125).
In normoxia at heavy exercise, Qp decreased slightly (97.56% of Qt) and QIPAVA represented 2.44% of Qt .
Instead in hypoxia at heavy exercise, Qp decreased significantly (85.25% of Qt) and QIPAVA increased significantly (14.75% of Qt), equal to QIPAVA of 3.48 L/min.
It was possible to demonstrate a negative contribution of QIPAVA directly on pulmonary gas exchange efficiency.
Furthermore, the model immediately identifies incorrect Qt measurements.

Conclusions: This new mathematical model is precise in calculating Qp and QIPAVA.
The required data are obtained through non-invasive instruments, easy to use and widespread in all hospitals. Qp differs significantly from Qt under some physiological conditions. The application of this model in the medical field is expected to enable further advancements in scientific research and clinical practice.
Indoor Bacterial and Fungal Aerosols as Predictors of Lower Respiratory Tract Infections Among Under-five Children in Ibadan, Nigeria
Authors: Fakunle Adekunle Gregory , JAFTA Nkosana , SMIT Lidwien A.M , NAIDOO Rajen N.
Published: May 2022

Aim
This study aimed to investigate the association between exposure to diverse indoor microbial aerosols and lower respiratory tract infections (LRTI) among children aged 1 to 59 months in Ibadan, Nigeria.
Methodology
One hundred and seventy-eight (178) hospital-based LRTI cases among under-five children were matched for age (± 3months), sex and geographical location with 180 community-based controls (under-five children without LRTI). Following consent from caregivers of eligible participants, a child’s health questionnaire, clinical proforma and standardized home-walkthrough checklist were used to collect data. Participant homes were visited and sampled for indoor microbial exposures using active sampling approach by Anderson sampler. Indoor microbial count (IMC), total bacterial count (TBC), and total fungal count (TFC) were estimated and dichotomized into high (> median) and low (≤ median) exposures. Alpha diversity measures including richness (R), Shannon (H) and Simpson (D) indices were also estimated. Conditional logistic regression models were used to test association between exposure to indoor microbial aerosols and LRTI risk among under-five children.
Results
Significantly higher bacterial and fungal diversities were found in homes of cases (R = 3.00; H = 1.04; D = 2.67 and R = 2.56; H = 0.82; D = 2.33) than homes of controls (R = 2.00; H = 0.64; D = 1.80 and R = 1.89; H = 0.55; D = 1.88) respectively. In the multivariate models, higher categories of exposure to lMC (OR = 2.67, 95% CI = 1.44–4.97), TBC (OR = 2.51, 95% CI = 1.36–4.65), TFC (OR = 2.75, 95% CI = 1.54–4.89), bacterial diversity (OR = 1.87, 95% CI = 1.08–3.24) and fungal diversity (OR = 3.00, 95% CI = 1.55–5.79) were independently associated with LRTI risk among under-five children.
Conclusions
Our study suggests an increased risk of LRTI when children under the age of five years are exposed to high levels of indoor microbial aerosols.
Subcutaneous tunnelling versus conventional insertion of peripherally inserted central catheters in hospitalized patients (TUNNEL-PICC): A study protocol for a randomized controlled trial
Authors: Kwon Yohan , Kim Eung Tae , Cho Soo Buem , Lee Jae Hwan , Shim Dong Jae
Published: May 2022

Background: Peripherally inserted central catheters (PICCs) are now widely used in modern medicine, and associated complications have also increased. Central line associated bloodstream infection (CLABSI) is the most serious complication because it can cause longer hospital stays and increase costs. Furthermore, it can contribute to dire consequences for critically ill patients. Subcutaneous tunnelling for central venous catheters is an accepted method to reduce the risk of CLABSI. However, it is not generally adopted for PICC placement in most hospitals because its safety and efficacy have not been fully evaluated. Methods: In this multi-institutional, prospective, non-blinded pragmatic randomized controlled trial, 1694 patients treated at five referral hospitals were assigned to one of two parallel arms (conventional and tunnelled PICC groups) using computer-generated stratified randomization. The conventional group underwent PICC placement by the usual practice. In the tunnelled PICC (tPICC) group, additional subcutaneous tunnelling was applied. Patients will be followed until PICC removal or the end of this study. The primary endpoint was whether subcutaneous tunnelling reduced the rate of CLABSI compared to the conventional method. The secondary endpoints are comparison of technical success rates, complications including exit-site bleeding or infection, and procedure time difference between the groups.Discussion: Subcutaneous tunnelling is a widely used method to reduce catheter-associated infection. However, it has not been thoroughly applied for PICC. A randomized trial is needed to more objectively assess the effects of subcutaneous tunnel in PICC placement. This TUNNEL-PICC trial will provide evidence for the effectiveness of subcutaneous tunnelling to decrease the risk of CLABSI.Trial registration: Clinical Research Information Service (CRiS) KCT0005521
Insights into the enhanced fluoranthene degradation in citric acid coupled Fe(II)-activated sodium persulfate system
Authors: Dong Jiaqi , Sheng Xianxian , Liu Yulong , Wang Peng , Lu Zhanpeng , Sui Qian , Lyu Shuguang
Published: May 2022

Polycyclic aromatic hydrocarbons (PAHs), which are present in contaminated groundwater, have attracted increasing attention because of their serious harm to humans. In this study, the degradation performance of fluoranthene (FLT), a typical tetracyclic PAHs in organic contaminated sites, was investigated in the persulfate (PS)/Fe(II)/citric acid (CA) system. The effects of PS, CA, and Fe(II) doses on FLT degradation were tested. With the molar ratio at 60/20/5/1 of PS/Fe(II)/CA/FLT, FLT removal reached 96.3% in 120 min, much higher than 62% removal without CA at the same PS and Fe(II) doses, indicating that the addition of CA could remarkably enhance the FLT degradation. The water quality conditions (pH, anions and humic acid) were also investigated for their effects on FLT degradation. The results of probe tests, electron paramagnetic resonance detection and scavenging experiments showed that and acted predominantly on FLT degradation. The influence of surfactants on FLT degradation was examined. Furthermore, the primary degradation intermediates of FLT were detected by GC-MS and the possible degradation pathways of FLT were proposed. Finally, the effectiveness of the PS/Fe(II)/CA process for the FLT degradation in actual groundwater demonstrated that the process has a great prospect for the remediation of FLT-contaminated groundwater.
Geophysical investigation of transmissibility and hydrogeological properties of aquifer system: A case study of Edem, Eastern Nigeria
Authors: Omeje Emmanuel T. , Ibuot Johnson C. , Ugbor Desmond O. , Obiora Daniel N.
Published: May 2022

This research study aimed at investigating the transmissibility magnitude of hydrogeologic units of Edem employing a vertical electrical sounding technique. This was as a result of the rapid increase in population and failures of water scheme projects in Edem. Hydraulic properties used in characterizing the transmissibility magnitude were calculated from values of aquifer resistivity and thickness. Results from the field data showed that the aquifer resistivity ranged from 34.800 to 67,561.200 Ωm while thickness ranged from 24.800 to 147.600 m. Fractional porosity with an average value of 0.290 ranged from 0.256 to 0.326. Values of surface area per unit pore volume and permeability range from 460.250 to 13,038.710 m−1 and 1.680E-09 to 1.973E-06 μm2 respectively. Hydraulic capillary radius ranges from 7.67 × 10−5 to 0.00217 m, while transmissivity values range from 0.8607 to 458.0727 m2/day. From the contour map, hydrogeologic units across the western and eastern parts of the area were depicted as having high indices of transmissibility magnitude. The northwestern part was characterized with very low indices of transmissibility. Plots of permeability against these hydraulic properties revealed their various coefficient of determination. The results from this study will assist in characterizing the hydrogeologic units of the area for proper groundwater exploration and management.
Identifying sources of infiltration and inflow in sanitary sewers in a northern community: comparative assessment of selected methods
Authors: Panasiuk Oleksandr , Hedström Annelie , Langeveld Jeroen , Viklander Maria
Published: May 2022

Infiltration and inflow (I/I) into sanitary sewers causes numerous negative effects on the whole wastewater management system and ultimately, on the receiving waters. Consequently, a number of methods have been developed to analyse the performance of sewer systems with respect to I/I, including: distributed temperature sensing (DTS), closed-circuit television (CCTV) inspections, flow and conductivity measurements, automatic or grab sampling of ammonium, smoke testing, and visual inspection of manholes. Such methods were compared in an application to sanitary sewers in a small community and assessed with respect to their accuracy and ability to identify locations of sources of I/I, as well as temporal and spatial resolutions of the obtained results. Furthermore, different approaches to ammonium sampling during I/I monitoring campaigns were discussed. It was concluded that among the methods tested in this study, DTS had the highest temporal and spatial resolution, while ammonium grab sampling showed promise for initial screening of large catchments.
Endocrine disruptors, estrogenic activity by the YES bioassay, and acute toxicity in Southeastern Brazil metropolitan surface waters
Authors: Nascimento Marilia , Oliveira-Santos Ana , Cunha Danieli , Felix Louise , Gomes Giselle , Rangel Carlos , Hauser-Davis Rachel , Fonseca Estefan , Maia-Bila Daniele , Baptista-Neto José Antonio
Published: May 2022

This study aimed to determine endocrine disruptors in urbanized rivers Maracanã and Mangue Channel in Rio de Janeiro the second most populated city in Brazil. Bisphenol A, 17β-estradiol, estriol, and 17α-ethinylestradiol were determined by high-performance liquid chromatography with a diode array detector and fluorescence detector In addition, the evaluation of estrogenic activity was performed by the YES bioassay (Yeast estrogen screen) with the Saccharomyces cerevisiae yeast, and acute toxicity assays were performed using Daphnia similis and Vibrio fischeri. Estrogenic activity in the water samples ranged from below the limit of detection (<LD) to 1.6 ng L-1, while bisphenol A ranged from 22.3 to 1325.2 ng L-1 and estrogens 17β-estradiol from <LD to 55.2 ng L-1, estriol from <LD to 313.7 ng L-1 and 17α-ethinylestradiol, from <LD to 409.4 ng L-1. The acute toxicity was not detected in both analyzed organisms. The present study indicates a serious level of pollution by the compounds evaluated with significant risks to the aquatic ecosystem, mainly for Guanabara Bay which receives urbanized river discharge. Therefore, recommending the need for systematic monitoring and mitigating actions in these water bodies.
Experimental Study on Light Transmitting Concrete Using Plastic Optical Fiber
Authors: Loganayagan S.
Published: May 2022

Abstract. The present study aims at manufacturing the concrete specimens by reinforcing optical fiber and scrutinizing it with the traditional concrete. The concrete specimens were subjected to totally different things such as compressive strength tests, light‐transmission tests, etc. The compressive strength results obtained for the semi transparent concrete specimens were virtually the same as that of the traditional concrete specimen. The results of the transmission take a look at were satisfactory because the Plastic Optical Fiber retained its potency. Thus, it's evident that the transparency of the concrete structures are often introduced with the insertion of optical fiber while not compromising the strength, that may be a breakthrough to the aspiration of achieving some new feat in modern architecture.
Nano Silica Particles as A Structural Build Up Agent for 3D Printing Cement Paste with Additional Accelerators
Authors: Sabu Sam V.
Published: May 2022

Abstract. 3D printing also commonly known Additive manufacturing (AM) is the layering of materials by a computer to build 3D shapes of desired materials. It's very handy for prototyping and working with geometrically complicated materials. It was founded and developed in the 1980s, but it was a costly and demanding procedure at the time, with few uses. It became quiet relevant and inexpensive in the 2000 and a variety of applications which includes product development, component manufacturing, and tool manufacturing, plastic, aerospace engineering metalworking, Foot wear, dental and medical applications, and electronics. Even the household uses of 3D printers were happening. The construction sector also started using 3D technology and the systems used were called 3D printers for construction Computer-aided design, or CAD design, or the usage of a 3D scanner are both used to build a 3D model.
Geopolymer Concrete Paver Blocks: A Review
Authors: Kavipriya S.
Published: May 2022

Abstract. Geopolymer Concrete is one of the emerging concretes with zero cement. Zero percent usage and hundred percentage utilization of pozzolanic material as source material increases the interest of researchers towards geopolymer concrete day by day. Also, reduction of emission of Co2 rate in environment by the less usage of cement consumption increase the thirst of utilizing geopolymer concrete towards academicians, environmentalists and researches. In geopolymer concrete the main source material which is highly embedded with huge percentage of silica and alumina is utilized instead cement. Stimulator solution, combined with Na2Si03 and NaOH is used for processing and activating polymerization process. As a result of polymerization process, chain links and bonds of Silicon-Oxygen-Aluminum are formed to stimulate the strength properties of concrete. Steam, oven and ambient temperature curing methods are preferred in this concrete. Nowadays, interest of geopolymer concrete turn over to applications of geopolymer products rather than construction of structural elements. Applications of geopolymer concrete include paver blocks, precast slabs, pipes, bricks, tiles, etc. Construction of paver blocks in geopolymer concrete plays an important role. This paper describes the review of GPC paver blocks for the past two to three decades which will help to update the knowledge of GPC paver blocks in all aspects.
Investigation on Strength Properties of Concrete using Steel Slag as a Partial Replacement for Fine Aggregate
Authors: Ashwathi R.
Published: May 2022

Abstract. The economic and ecological performance of normal concrete can be increased by modulating fine aggregate content with a series of combinations of steel slag which possess different physical and chemical behaviour based on its cooling method, heating processes. Many research shows that magnetic separating of steel slag increases its efficiency towards integrating with clinker by 50% compared to integrating of clinker with non-magnetically separated steel slag. It has proved to be an impressive replacement material in concrete surfaces where high skid resistance is essential. Steel slag produced in various types of furnaces have different characteristic nature, blast furnace slag (BFS) has hydraulic and cement properties when used in water-bound macadam roads and also in flexible and rigid pavements. Issue in steel slag is energy consumed in its production and transportation where it is utilized, if energy consumed in slag grinding/magnetic separation is high when compared to cement calcining and grinding, then it would not be economical in replacement criteria. This study exhibit mechanical properties of concrete with partial replacement of fine aggregate with steel slag in distinct proportions. The optimum amount of replacement in fine aggregate is found to be 20% giving a strength increment of 8% in the compressive strength category. In split tensile and flexural strength criteria strength increment of 7.5% and 40.625% is observed. There are many practical implications of steel slag in the construction industry, road constructions, and clinker substitutes as granulated BF slag, water treatment plants, evidently many researches have proved slag as productive coarse aggregates replacement.
Experimental Analysis on Utilizing Sugarcane Bagasse Ash as a Replacement for Cement
Authors: Hemavathi R.
Published: May 2022

Abstract. Construction industry is estimated to consume nearly 30-35% of natural resources and associated to major global pollutions. It is essential to move our path into a sustainable way of construction practices, to conserve natural resources for the future generation. Several researchers had investigated the various possibilities of alternatives to produce sustainable green building materials from industrial by-products, for example, blast furnace slag, fly ash and silica (SiO2). Presently, there has been an attempt to use the large amount of Sugarcane Bagasse Ash (SBA) which is formed when using the bagasse-biomass fuel in electric generation industry. Due to availability of Cement kiln dust (CKD) and Sugarcane Bagasse Ash (SBA) in large amounts, it appears to be cost effective and eco-friendly by the applications for these industrial by-products. The overall goal of this research study was to replace cement by certain percentage through potential applications for the Cement kiln dust (CKD) and Sugarcane Bagasse Ash (SBA) based on a detailed characterization of the materials. The analyses are discussed in terms of Setting time, Consistency test and Compressive Strength. As a result, Sugarcane Bagasse Ash (SBA) for a certain percentage replaced in cement increases the strength of mortar cube but if it exceeds 20%, then the strength starts to decrease.
Buckling Behaviour of Cold Formed Steel Column Subjected to Axial Compression Loading
Authors: Jayanthi V.
Published: May 2022

Abstract. Cold formed steels are durable, reliable and cost effective options for low and mid-rise buildings. Analysing the behaviour of cold formed steel structures is a vital prerequisite for their further large scale applications. The previous studies on cold formed steel structures stated stiffness as a major reason for its application in the construction field. In this paper the cold formed steel structures were analysed for their behaviour when subjected to axial compression loading. The different heights of columns such as 700 mm, 750 mm and 800 mm has been taken for a constant thickness of about 2 mm. The strength and displacement of axial member against loading was investigated and the results were compared with the load displacement curve obtained numerically using Abaqus and CFS software. In this investigation, an attempt is made to study the ultimate load carrying capacity and the corresponding displacement with respect to height and the mode of failure.
Experimental Investigation on Partial Replacement of Cement with Metakaoline, Fly Ash and Silica Fume in Concrete
Authors: Pradeep Kumar C.
Published: May 2022

Abstract. The process of construction begins some thousand years ago and the monuments that we are seeing are the proof for that. The materials that are being used in the construction some thousand years ago are not the same which are being used nowadays. The construction materials get modified and new inventions are taking place due to the continuous research. The scope of this project is to make building materials sustainable and to make them eco-friendly. In the olden days lime was used as a mortar and now it’s being replaced by cement. But still research is going on to make better binding materials to make construction reliable. As an initiative, in our project we are going to partially replace cement with metakaoline, fly ash and silica fume simultaneously. We are going to replace cement with each additive in the order of 5%, 7.5%, 10%, 12.5%, and 15%. Therefore, the summation of replacement of all additives will be in the order of 15%, 22.5%, 30%, 37.5%, 45%. The concrete specimens are casted based on the replacement ratios along with the conventional concrete specimens. The specimens are subjected to the various laboratory tests and it was found that a 10% replacement of cement with additive materials to be optimum.
Apixaban versus Warfarin for Treatment of Venous Thromboembolism in Patients Receiving Long-Term Dialysis
Authors: Wetmore James B. , Herzog Charles A. , Yan Heng , Reyes Jorge L. , Weinhandl Eric D. , Roetker Nicholas S.
Published: May 2022

Background and objectives

The association of apixaban compared with warfarin for the treatment of venous thromboembolism in patients receiving maintenance dialysis is not well studied.

Design, setting, participants, & measurements

We conducted a retrospective cohort study of Medicare fee-for-service beneficiaries receiving dialysis using United States Renal Data System data from 2013 to 2018. The study included patients who received a new prescription for apixaban or warfarin following a venous thromboembolism diagnosis. The outcomes were recurrent venous thromboembolism, major bleeding, and death. Outcomes were analyzed using Cox proportional hazards regression for intention-to-treat and censored-at-drug-switch-or-discontinuation analyses. Models incorporated inverse probability of treatment and censoring weights to minimize confounding and informative censoring.

Results

In 12,206 individuals, apixaban, compared with warfarin, was associated with lower risks of both recurrent venous thromboembolism (hazard ratio [HR], 0.58; 95% confidence interval [95% CI], 0.43 to 0.77) and major bleeding (HR, 0.78; 95% CI, 0.62 to 0.98) in the intention-to-treat analysis over 6 months of follow-up. However, there was no difference between apixaban and warfarin in terms of risk of all-cause death (HR, 1.04; 95% CI, 0.94 to 1.16). Corresponding hazard ratios for the 6-month censored-at-drug-switch-or-discontinuation analysis and for corresponding analyses limited to a shorter (3-month) follow-up were all highly similar to the primary analysis.

Conclusions

In a large group of US patients on dialysis with recent venous thromboembolism, we observed that apixaban was associated with lower risk of recurrent venous thromboembolism and of major bleeding than warfarin. There was no observed difference in mortality.
A Survey on Sign Language Recognition with Efficient Hand Gesture Representation
Authors: Gaikwad Priyanka , Trivedi Kaustubh , Soma Mahalaxmi , Bhore Komal , Agarwal Prof. Richa
Published: May 2022

Abstract: Image classification is one amongst classical issue of concern in image processing. There are various techniques for solving this issue. Sign languages are natural language that want to communicate with deaf and mute people. There's much different sign language within the world. But the most focused of system is on Sign language (SL) which is on the way of standardization there in the system will focused on hand gestures only. Hand gesture is extremely important a part of the body for exchange ideas, messages, and thoughts among deaf and dumb people. The proposed system will recognize the number 0 to 9 and alphabets from American language. It'll divide into three parts i.e., pre-processing, feature extraction, classification. It'll initially identify the gestures from American Sign language. Finally, the system processes that gesture to recognize number with the assistance of classification using CNN. Additionally, we'll play the speech of that identified alphabets. Keywords: Hybrid Approach, American Sign Language, Number Gesture Recognition. Feature Extraction.
Handwritten Digit Recognition
Authors: Singh Priyanshu , Pawar Pranali , Raj Nikhil
Published: May 2022

Abstract: Digital recognition is also remarkable an important issue. As handwritten digits are not a same size, thickness, position and direction, in this case by the way, various difficulties should be considered find the handwritten digital recognition problem. I unique and a variety of creative styles for different people moreover have an influence on the model as well the presence of digits. It is a strategy to see again edit written digits. It has a wide variety applications, for example, scheduled bank checks, post offices and tax documents and so on. The purpose of this project is to use the classification algorithm to identify handwritten digits. Background results are probably the most widely used Machine Learning Algorithms such as SVM, KNN and RFC and in-depth reading calculations like CNN multilayer using Keras and Theano and Tensorflow. Using these, 98.70% accuracy was used by CNN (Keras + Theano) compared to 97.91% using SVM, 96.67% using KNN, 96.89% using RFC was obtained. Keywords: SVM, RFC, KNN, CNN
Comparative Study between Hydroforming and Hot Stamping
Authors: Paradkar Rohan R. , Aloni Onkar S. , Umre Sandhya M.
Published: May 2022

Abstract: Nowadays the requirement of a pollution free (eco-friendly) manufacturing technology is need of the hour, because of the increase in global warming. This research paper describes the advantages of hydroforming over hot stamping process with the help of comparative study on some important aspects. Hydroforming prototypes can be manufactured quickly and inexpensively, enabling a smoother testing process and faster implementation of design improvements. This process saves resources and energy because it leaves no carbon dioxide emissions. Production is carried out with the help of hydraulic pressure and minimal heating.
Deformation and Stress Analysis of Sheet Hydroforming in Car Frame T-Joint
Authors: Aloni Onkar S. , Paradkar Rohan R. , Umre Sandhya M.
Published: May 2022

Abstract: Hydroforming is a relatively new metal forming process that offers many advantages over traditional cold forming processes, including the ability to produce more complex components with fewer operations. For certain geometries, hydroforming technology makes it lighter, stiffer, cheaper to manufacture, and requires less blanks, resulting in less material waste. This paper focuses on the analysis of composite T-joints which are used in automobiles under various loads. It is modelled analysed using CATIA V5 and ANYSYS software’s respectively. There are several studies on design optimization of automotive T-joints. This paper depicts deformation and stress analysis of TJoint, when made using sheet hydroforming. Keyword: Hydroforming, Metal Forming, Cold Forming, T-Joint, Catia, Ansys
Virtual Shopping Assistant for Online Fashion Store
Authors: Deshmukh Prof. Anushree , Shah Smit , Puthran Heena , Shah Naisargi
Published: May 2022

Abstract: A new way for individuals to interact with computer systems will be done through chatbots or conversational interfaces. Historically, introducing a matter answered by a software package involves employing a program or filling out a type. The technology at the core of the increase of the chatbot is NLP i.e., Natural Language Processing. Sequence to Sequence (often abbreviated to seq2seq) fashions is a specific type of Recurrent Neural Network architectures that we commonly use (but no longer restricted) to clear up complicated Language issues like Machine Translation, Question Answering, growing Chatbots, Text Summarization, and so forth. Recent advances in machine learning have greatly improved the accuracy and effectiveness of NLP, creating chatbots a viable choice for several organizations like e-commerce, Customer service, Conversational apps, social media, Sales/Marketing/Branding, as Voice modules, Travel industry, Medicine, Hospitality, Human Resources etc. An NLP primarily based chatbot is a pc software or synthetic brain that communicates with a patron by means of textual or sound strategies This improvement in NLP is firing a great deal of additional analysis and research which should lead to continued growth in the effectiveness of chatbots in the years to come. Stochastic gradient descent (often abbreviated SGD) is an iterative approach for optimizing an goal characteristic with appropriate smoothness homes (e.g. differentiable or sub differentiable). Usage of Chatbots can also prove to be beneficial in ways like economically offering 24/7 service, improving customer satisfaction, reaching a younger demographic, reducing costs, increasing revenue and much more. Keywords: Chatbots, Natural Language Processing (NLP), Stochastic Gradient Descent (SGD), Sequential Model, Machine Learning
Fertilization in potato (Solanum tuberosum L. group Phureja)
Authors: Lagos-Burbano Tulio César , Betancourt Andrade Maria Dyanela
Published: May 2022

Potato fertilization is an important and pricey task, especially when soil analysis is not considered to define fertilization according to its nutritional requirements. The objective of this study was to evaluate genotypes of Solanum tuberosum group Phureja at different levels of fertilization (LF) in four localities in the department of Nariño. The LF were 0, 60, 70, and 80% of the dose used in the traditional fertilization of the area (900Kg ha-1 of 10-30-10). The split-plot design was used. The LF was located in the main plot, and the genotypes were in the subplots. The genotypes with the best performance in Botana were UdenarStCr10 with 60%, 70%, and 80% LF, UdenarStCr42 with 60% and 80% LF, and UdenarStCr42 with 80% LF with yields between 29.92 and 38.22t ha-1. In the locality of Gualmatán, the best genotype with a LF of 60% was UdenarStCr10, with 70% were UdenarStCr10, UdenarStC42 and UdenarStCr54, and with 80% were UdenarStCr1, UdenarStCr42 and UdenarStCr54 whose yields ranged between 43.58 and 52.91t ha-1. In San Juan, they were UdenarStCr10 with 60% and 80% LF, UdenarStCr42 and UdenarStCr54 with 70% LF with yields between 9.53 and 18.85t ha-1. UdenarStCr1, UdenarStCr10, UdenarStCr42, and UdenarStCr45 responded well to low fertilization levels in all locations. As a result, evaluating them in other environments is recommended to use them as commercial crops or as parents in plant breeding.
Amor filosófico, amor poético: conformações do pensamento em António Franco Alexandre
Authors: Joaquim Ana Cristina
Published: May 2022

Trata-se de perceber o modo pelo qual António Franco Alexandre se coloca diante do discurso poético, levando em consideração a filosofia enquanto instituição discursiva que não detém a exclusividade do exercício do pensamento. Com esse objetivo, importa desenvolver um debate acerca das disciplinas filosófica e poética, a partir de pensadores (Lucrécio, Nietzsche, Derrida) que se ocuparam de complexificar as fronteiras que demarcam as atividades discursivas entre a diferença e a repetição, entre a alteridade e a identidade. Trata-se, por fim, de expor um pensamento sobre o amor com foco no livro de poemas Duende, publicado em 2002 em diálogo com a conferência de Federico García Lorca Teoría y juego del duende, de 1933.
“Olha a minha carta para o mundo”: primeira tradução da poesia completa de Emily Dickinson para o português
Authors: Moura Alves Fernandes João Pedro
Published: May 2022

Nesta resenha da primeira tradução da Poesia completa de Emily Dickinson para a língua portuguesa, discutimos as diretrizes do sólido projeto editorial, crítico e tradutório tocado por Adalberto Müller. Nosso foco foi o volume 1 — os fascículos, publicado em 2020 pelas Editoras da Universidade de Brasília e da Unicamp. Simultaneamente à apresentação do projeto e das características específicas do primeiro volume, comentamos dados fulcrais à compreensão da importância da obra de Dickinson e da edição ora em análise.
A seta imóvel, o trajecto invertido e o arqueiro cego
Authors: Molder Maria Filomena
Published: May 2022

Este texto ocupa-se com problemas filosóficos insolúveis (logoi) e artes poéticas singulares, por intermédio da imagem do arco e da seta, sob a égide do deus Apolo, o transmissor entre os Gregos do arco da morte e o senhor do logos. Neste contexto, os principais autores em exame, Zenão de Eleia, Dante e Herberto Helder, formam um conjunto excêntrico, apenas justificado pela imagem escolhida e pelos seus surpreendentes efeitos filosóficos e poéticos.
Os domínios da focalização: um estudo experimental
Authors: Carnaval Manuella , A. de Moraes João , Rilliard Albert
Published: May 2022

Este artigo visa desenvolver um estudo experimental sobre a percepção de domínios focais no Português do Brasil (PB). Utilizando as noções de Foco Amplo e Foco Estreito, propomos um contínuo de extensões abarcadas pela focalização, baseado nos domínios hierárquicos propostos pela teoria da Fonologia Prosódica. São considerados, sobretudo, a palavra fonológica (ω) e o sintagma fonológico (φ), descritos como domínios da entoação no PB. Após a aplicação de um experimento perceptivo multimodal, a análise estatística dos resultados revelou que a palavra fonológica é o domínio preferível de aplicação da focalização no PB, além de apresentar uma interessante sistematicidade nas confusões ocorridas no domínio complexo do sintagma fonológico e de atestar que a adição da modalidade visual não aumenta (nem diminui) significativamente a identificação já eficiente do domínio focal. Além disso, uma análise qualitativa de padrões melódicos selecionados nos permitiu tecer importantes considerações sobre a implementação da focalização na estrutura prosódica do PB.
DÍVIDA PÚBLICA ESTADUAL E GASTOS COM O FUNCIONALISMO: UMA ANÁLISE RECENTE PARA OS ESTADOS DO NORDESTE
Authors: Nunes de Souza Jose Antonio , Moura da Costa Fagner , Da Silva Ferreira Francisco Danilo , Gledson e Silva William
Published: May 2022

Este artigo teve o objetivo de analisar a influência dos gastos com pessoal e encargos diante da dívida pública consolidada dos estados nordestinos, no período 2015/2018. Metodologicamente, usou-se um modelo de regressão com dados em painel para os estados da região Nordeste abrangendo o período mencionado. Os modelos estimados consistiram em modelo de dados empilhados (pooled), modelo de efeitos fixos e modelo de efeitos aleatórios, que, após a verificação de testes estatísticos, optou-se pelo modelo de efeitos aleatórios. Os dados referentes a participação das despesas de pessoal na receita corrente dos estados nordestinos revelam desempenhos próximos e, consequentemente excedentes do teto imposto pela Lei de Responsabilidade Fiscal na perspectiva das despesas com pessoal. Em termos econométricos, o coeficiente associado a despesa com pessoal estimado pelo modelo de efeitos aleatórios foi positivo e estatisticamente significativo sugerindo uma relação positiva entre essa variável e a dívida pública estadual. Essas evidências corroboram a discussão acerca da necessidade do controle dos gastos com pessoal no processo de ajuste das finanças dos estados.
UM ESTUDO SOBRE OS SERVIÇOS ECOSSISTÊMICOS NO MUNDO BASEADO NA ANÁLISE BIBLIOMÉTRICA DA LITERATURA INTERNACIONAL
Authors: Dos Reis Josimar Vieira , Freire-Silva Jadson , Silva Elisabeth Regina Alves Cavalcanti da , França Luciana Mayla de Aquino , Leitão Mario De Miranda Vilas Boas Ramos , Galvíncio Josiclêda Domiciano
Published: May 2022

Este estudo é fruto de investigação desenvolvidos no estudo de doutorado em desenvolvimento e meio ambiente do autor principal, que tem como um dos temas do seu objeto de pesquisa os serviços ecossistêmicos. O estudo teve como objetivo identificar tendências globais de pesquisa envolvendo artigos altamente citados sobre Serviços Ecossistêmicos (SE) do ano 2000 até o ano 2020. A pesquisa é explicativa com abordagem quantitativa utilizando a análise bibliométrica a partir de levantamento realizado na base de dados NetworkAnalysis Interface for Literature Studies (NAILS) como fonte de artigos publicados de 2000 a 2020, correspondendo aos quatro termos de busca. Os resultados permeiam o panorama geral das pesquisas sobre SE. Apresentando pela ordem, os periódicos que mais foram citados correspondem a (1); autores mais citados em estudos sobre os SE (2); amostra do ano de maior produção de estudos sobre SE (3); aplicação por localização, área científica e escolha do SE (4). Alguns pontos levantados, mostra que a totalidade dos estudos dos SE, tem caráter conservacionista, outro apontamento, mostra que muitos estudos sobre os SE têm caráter econômico/monetário, buscando o uso sustentável dos ambientes.
Positive QRS complex in limb lead 2 with negative QRS in lead 3 on surface electrocardiogram is not indicative of a Right sided accessory pathway.
Authors: KUMAR SHARATH , Thomas Garry R.
Published: May 2022

We read, with interest, the article by Deb et al. entitled
“Positive QRS complex in limb lead 2 with negative QRS in lead 3
on surface electrocardiogram: A novel predictor for anterior location of
right sided accessory pathways.” We would like to
raise a few concerns regarding the interpretation of the
electrocardiographic (ECG) sign they have highlighted.