bluuebunny/crossref_metadata_2025 huggingface dataset:
AMBIVALENCE OF CHRONIC INFLAMMATION IN THE MUSCULOUS STOMACH
Authors: Shtygasheva O. V. , Ageeva E. S.
Published: November 2020

For peptic ulcer disease, the etiological role of H. pylori infection has been proven, 60-90% of gastric cancer cases are associated with H. pylori. The bacterium is recognized as a first-order carcinogen. An association has been established between the successful elimination of H. pylori and a reduced risk of gastric cancer and relapse of peptic ulcer. In the pathogenesis of chronic inflammation in the gastric mucosa associated with H. pylori, there are reference points that determine the further path of development of the pathology. If peptic ulcer is not a consequence of the direct damaging effect of NSAIDs, it is associated with the development of gastritis. In gastric ulcer, gastritis is found in both the antrum and the fundus of the stomach
Atrophy of the glands begins in the antrum, then its foci are found in the fundus on the front and back walls. Gradu- ally they increase in size, merge with each other, the acid secreting zone decreases, and the border between the fundus and pyloric glands shifts in the proximal direction.
With atrophic fundus gastritis, the likelihood of developing high ulcers and stomach cancer increases. Significant increase in apoptosis processes with relative rigidity of proliferation leads to the formation of ulcer, and carcinogenesis is due to excessive proliferation and accumulation of cell mutations. One of the subjects of damage is Cag A H. pylori protein, which implements remodeling of the gastric epithelial barrier. Among its effects are modulation and impaired proliferation of gastric epithelium, leading to morphological changes. The aggressive action of Cag A protein enhances toxic doses of alcohol and smoking, supporting inflammation and causing damage to the gastric mucosa.
Despite the common etiology and pathogenesis of gastric ulcer and gastric cancer, the relationship with the de- velopment of atrophic pangastritis and the similarity of convention risk factors determines that the key point in the manifestation of gastric cancer is a genetic predisposition in the form of gene polymorphism causing severe atrophy as a result of chronic inflammation.
EVALUATION OF THE INFLUENCE OF ARBUSCULAR MYCORRHIZAL FUNGI ON ECONOMICALLY VALUABLE INDICATORS OF ONION
Authors: Abdurashytov S. F. , Nemtinov V. I. , Puzanova E. V. , Gritsevich K. S. , Belova I. V. , Grunina E. N. , Abdurashytova E. R. , Klimchuk A. V.
Published: November 2020

Allium cepa L. is one of the main vegetable crops. It is actively used in food industry and medicine. The biochemical composition of plants, both bulbs and green leaves, in different periods of growth changes depending on the variety, environmental and agrotechnical conditions of plant cultivation. Representatives of the genus Allium are highly sensitive to the presence of arbuscular mycorrhiza (AM) in soil due to root development features. The aim of our work was to identify effective associations of AM fungi to increase the productivity and quality of onions in the conditions of southern chernozem. Pot and field experiments were carried out with associations of AM fungi and onion varieties from the collection of the Research Institute of Agriculture of Crimea. The initial assessment of the AM fungi collection was conducted in the pot with a sterile substrate under artificial lighting conditions according to the intensity of mycorrhizal colonization and the accumulation of phytomass of the storage plant. Field studies were carried out on southern carbonate chernozem in 2019. It is established that the AM fungi association M9 significantly exceeds the referent in the arbuscules abundance by 13.3 %. Association 1–16 showed the most considerable abundance of vesicles, which was 11.1–13.3 % higher than other variants of this experiment. The dry mass of onion shoots had a significant increase of 11.719.7 mg per plant (38.865.8 %) from inoculation by associations AM S1-4, 1-16 and M9. The positive effect of the AM fungi association 1-16 on the accumulation of phytomass in the onset phase of bulb formation and onion productivity of the onion variety Yaltinskiy plus and line 11A with an increase by 0.690.8 g / plant (31.351.7 %) and 1.11.3 t / ha (14.114.9 %), respectively, and an increase in the content of ascorbic acid by 18.524.4 % to the variant without treatment are shown.
INTRASPECIFIC POLYMORPHISM OF PLANTS IN THE СENTRAL RUSSIAN FOREST-STEPPE
Authors: Mukovnina Z. P. , Voronin A. A.
Published: November 2020

Research of the flora of some areas of the Central Russian forest-steppe shows that a number of plants has deviations from the main species characteristics. The fact that there is a continuous series of variations from individual to species level in nature has long been known for a long time (Darwin, 1991). The reasons and results of this are very different and unpredictable. The ability of plants to change their phenotype is genetically determined. The scope of intraspecific differentiation depends on many external causes. The intraspecific potential of plants reveals itself when ecological situation and geographical fragmentation modify. In result, populations which significantly differ from the main genotype are formed. The impact of new environmental conditions is shown in the examples of Genista tinctoria L., Achillea millefolium L., Salvia pratensis L. The Trifolium lupinaster or Lupinaster pentaphyllus is an example of the introduction of geographically distant genetically stable races. Some species can be represented by different morphobiotypes. For example, erect (haying) and lying (pasture) forms of Lotus corniculatus, Medicago falcata, Astragalus onobrychis. There are some transitional forms. Populations of tall and low growing Anemone sylvestris were observed. A pronounced manifestation of intraspecific diversity is the polychrome of flowers. It was found in рlants from different families: species of iris, Schrenka tulip (Tulipa suaveolens), lily of the Saranka (Lilium pilosiusculum) and others. The collection of the botanical garden for over 20 years contains garden forms of plants of natural flora, which appeared due to spontaneous new formations. These are variegated forms of Aegopodium podagraria and Galeobdolon luteum. The results of the introduction of species and intraspecific diversity of rare and economically valuable plants in the Botanical garden of the Voronezh state University are presented.
PENGARUH KUALITAS PRODUK TERHADAP LOYALITAS KONSUMEN DENGAN VARIABEL MEDIASI KEPUASAN KONSUMEN PADA RUMAH MAKAN AMPALU RAYA PADANG
Authors: Kurnia Iqbal , Besra Eri
Published: November 2020

Abstract: This research was conducted to determine the effect of productquality on consumer loyalty with mediating variables of customersatisfaction at the Ampalu Raya Padang Restaurant. To determine thesample in this study using simple random sampling with the criteria, (a)Answering domiciled in the city of Padang, (b) Knowing the Ampalu RayaRestaurant, (c) Medium or ever making a purchase more than twice. Thisstudy used a sample of 150 respondents obtained from the Hair method.This study uses quantitative methods and survey methods in collectingdata about attitudes, feelings, beliefs of past behavior and thoughts relatedto SEM-PLS 3 software. The results of this study reveal the quality of foodthat results in significant consumer loyalty in Ampalu Raya Restauant,product quality is important for consumers at Ampalu Raya Restaurant,customer satisfaction affects consumers significantly at Ampalu RayaRestaurant, customer satisfaction is related fully mediating product qualityto customers at Ampalu Raya Restauant. From the R2 value of customersatisfaction variables can be determined by the poduct quality variable of54.7 percent explained by other variables that are not examined, customerloyalty can be explained by product quality variable and customersatisfaction by 56.3 percent, the rest explained by variables othervariables not examinded.Key Words: Product Quality, Consumer Satisfaction, Consumer Loyalty
LONG-TERM RESULTS OF TREATMENT OF PATIENTS WITH SUBUNGUAL MELANOMA
Authors: Gafton Georgiy , Anisimov Valentin , Matsko Dmitriy , Ivantsov Aleksandr , Gafton Ivan , Myasnyankin M.
Published: November 2020

At the N.N. Petrov Research Institute of Oncology from 1986 to 2015 there were performed 445 radical operations for skin melanoma of upper and lower extremities in patients aged 18 to 87 years. The present study analyzed data of 40 patients with morphologically confirmed diagnosis of “subungual melanoma” (SM). Long-term results and causes of death were evaluated in all operated patients. A 1-year survival rate of SM patients, whatever stage of disease was 90%, a 5-year overall survival rate - 47%, while only 20% of patients have survived a 10-year line. Overall survival median was 55 ± 9.4 months (95% CI, 36.4-73.5). The probability of death of radically operated SM patients in the next 5 years after surgical treatment from co-morbidities did not exceed 10%. SM patients had the worst prognosis as compared with patients with skin melanoma of upper and lower limbs (p = 0,0001).
EXPERIMENTAL EVIDENCE FOR THE MOST EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY (PIPAC)
Authors: Zakharenko Aleksandr , Bagnenko Sergey , Yakovleva Mariya , Blyum Natalya , Ten Oleg , Zaytsev Danila , Trushin Anton , Belyaev Mikhail , Natkha Aleksandr , Kovalchuk Yu.
Published: November 2020

Peritoneal carcinomatosis (PC) is one of metastatic spread variant of malignant tumors, which shows significantly poor prognosis in patients. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) - is a modern regional therapy method for implantation metastases. Currently there are still unresolved issues in native equipment, optimal chemotherapy drugs doses for PIPAC, ability in adjuvant and neoadjuvant application of method and a combination with surgical treatment. Concerning this we carried out series of experimental studies on animal model (rabbits, n=71), which resulted in development of the device for laparoscopy aerosol chemotherapy also with selection of effective and safe PIPAC mode.
THE EXPERIENCE OF THE ENTRY OF THE CHELYABINSK POPULATION-BASED CANCER REGISTRY INTO THE IARC INTERNATIONAL ASSOCIATION OF CANCER REGISTRIES
Authors: Aksenova Irina , Domozhirova Alla , Vazhenin Andrey , Novikova Tatyana
Published: November 2020

The registration system of cancer cases has been established and perfected over the last half a century across the world. A unified approach to the registration of cancer cases and provision of high quality cancer registry data are the key to reliable epidemiological indicators in oncology as the essential basis for development of cancer control programs. Any deviations in the approach to registration of cancer cases can distort the epidemiological pattern and lead to incorrect prioritization and misallocation of resources. The Russian Federation has experienced a number of problems in the cancer registry system that requires thoughtful organizational solutions. Possible improvements are here addressed on the background of the application of Chelyabinsk Population-based Cancer Registry for inclusion in Cancer in Five Continents and other IARC publications.
LIQUID BIOPSY INDEXES AS PREDICTIVE MARKERS OF CHEMORADIOTHERAPY EFFICACY IN PATIENTS WITH PANCREATIC CANCER
Authors: Ivanov Sergey , Korytova Luiza , Ovchinnikov Igor , Vlasova Ye.
Published: November 2020

Patients with stage IV of pancreatic cancer were locally irradiated by 51 Gy total dose (fraction dose was 3 Gy). Gemcytabin, gemsar + carboplatin, or carboplatin + etoposid + 5-fluorouracil were intraarterially administered as chemotherapy preparations. DNA radiosensitivity biomarkers in patient blood were determined before the treatment start. There was revealed interrelation between value of biochemical index and life span patient. The DNA blood radiosensitivity index determinations are enabled to predict personally the results more success treatment in patients with pancreatic cancer after the use of abovementioned regimens of chemoradiotherapy.
SOCIO-PSYCHOLOGICAL ASPECTS OF THE QUALITY OF LIFE OF ELDERLY PATIENTS WITH PROSTATE CANCER AFTER RADIATION THERAPY
Authors: Tkachenko Galina , Gladilina Irina , Stepanova Aleksandra , Potapova Anna , Antonov Anatoliy , Merzlyakova A.
Published: November 2020

The paper presents results of clinical and psychological studies of the quality of life of elderly patients with prostate cancer following radiation therapy. Socio-psychological aspects of the quality of life were assessed using a modified scale of self-evaluation of Dembo-Rubinstein. In 3-6 months after radiation therapy there was noted significant reduction, compared to the beginning of treatment, on scales: «satisfaction with communication», «satisfaction with health», «satisfaction material conditions», «satisfaction with sexual relations», «satisfaction with activity», «satisfaction with leisure time and rest». Average indices of scales «satisfaction with health», «satisfaction with sexual relations», «satisfaction with leisure time and rest» fell below the middle. At the same time patients were not depressed by their situation did not fixed on thoughts about the disease, on the contrary the mood was significantly higher compared to the initial course of radiotherapy that could be associated with the psychological characteristics of the age of the patients in our sample.
CYTOLOGICAL AND IMMUNOCYTOCHEMICAL DIAGNOSIS OF TUMOR PLEURITIS
Authors: Novik Viktor , Nefedova A. , Yakubo Ye. , Ivanov O. , Shalina Yekaterina , Vladimirova Anna , Mikhetko Alla , Krasilnikova Larisa , Klimenko Viktor , Lindeberg T.
Published: November 2020

Cytological examination of smears from the sediment after centrifugation of pleural fluids was performed in 479 patients who underwent examination and treatment at our institution in 2014-2016. In 249 (52%) patients tumor cells were not detected in smears, in 230 (48%) observations a suspicion (28 observations) or a confident conclusion (202 observations) on the presence of malignant tumor cells in the exudates was cytologically expressed. In 38 cases immunocytochemical studies was additionally performed. In two observations a false-negative conclusion about the absence of tumor cells in smears was expressed. The sensitivity of the cytological study in the diagnosis of malignant pleuritis was 99.0%. Affirmative cytological conclusions on the presence of malignant pleuritis were given in 87.0% of observations, suspicious cytological responses - in 12.0% of cases. Immunocytochemical studies significantly expanded the possibilities of cytological research and were of great importance in the diagnosis of metastases of tumors of unknown primary localization.
LONG-TERM RESULTS OF COMBINED TREATMENT FOR DUCTAL PANCREATIC HEAD ADENOCARCINOMA BY MEANS OF INTRAARTERIAL PERIOPERATIVE CHEMOTHERAPY WITH OXALIPLATIN AND GEMCITABINE
Authors: Pavlovskiy Aleksandr , Polikarpov Aleksey , Moiseenko Viktor , Popov Sergey , Granov Dmitriy , Statsenko A.
Published: November 2020

Aim. Evaluation of long-term results of perioperative regional chemotherapy with gemcitabine and oxaliplatin in combined treatment of ductal adenocarcinoma of the pancreatic head.
Material and methods. The first group consisted of 52 patients who received combined treatment: neoadjuvant chemoembolization (CE) with gemcitabine (400 mg / m2) and oxaliplatin (50 mg / m2) (GemOx), operative treatment, as well as up to 6 courses of chemoinfusion (CI) in the celiac trunk of gemcitabine (1000 mg / m2) and oxaliplatin (75 mg / m2) in the adjuvant regime. In the second group of 51 patients, perioperative regional chemotherapy (neoadjuvant CE and adjuvant CI) with gemcitabine (1000 mg / m 2) (Gem) was performed. 54 patients of the third group performed only operative intervention.
Results. No complications associated with medical-diagnostic angiography and catheterization were observed. The median of life expectancy in the group of patients who received only operative treatment was 8.4 ±1.2 months, in the group of perioperative chemotherapy Gem-22.3 ± 1.5, in the group of patients who underwent perioperative regional chemotherapy GemOx-26 ± 1.1 months. Five-year survival rates in the groups were 0%, 10% and 13% and respectively
Conclusions. A use of regional chemotherapy with gemcitabine and oxaliplatin can be regarded as a useful and effective step in combined treatment of pancreatic head adenocarcinoma.
ANTICANCER ACTIVITY OF DOXORUBICIN CONJUGATES WITH DENDRITIC POLYMERS OF SECOND GENERATION AND VECTOR PROTEIN IN MODEL SYSTEMS IN VITRO AND IN VIVO
Authors: Zamulaeva Irina , Severin Yevgeniy , Kondrasheva Irina , Zhunina Olga , Makarenko Sergey , Nikolskaya Yelena , Yabbarov Nikita , Orlova Nina , Churyukina Kristina , Matchuk Olga , Matveev A.
Published: November 2020

Anticancer activity of doxorubicin (Dox), its conjugates with the second generation dendritic polymer (G2-Dox) and vector protein (recombinant third domain of alpha-fetoprotein - 3D-G2-Dox were studied in vitro and in vivo within the framework of the development of selective transport system of anticancer drugs to the target cells. The objects of the study were MCF-7 and MCF-7/MDR1 breast cancer cells, differing in chemosensitivity as well as mouse melanoma line B16. Anticancer activity of G2-Dox and 3D-G2-Dox was demonstrated in vivo (for B16 melanoma) and in vitro (for chemoresistant MCF-7/MDR1 cells, expressing P-glycoprotein). The effectiveness of anticancer action of G2-Dox and 3D-G2-Dox did not differ from that for free Dox. However for chemosensitive line MCF-7 free Dox proved to be more effective drug. It is important that the conjugates, and particularly 3D-G2-Dox, accumulated much weaker than the free Dox in normal cells isolated from bone marrow, spleen and liver of mice. The findings suggest that the main benefit from the possible use of such conjugates can be associated with reduced toxic effect of Dox on normal tissues and organs.
QUANTITATIVE AND QUALITATIVE CHARACTERISTICS OF METASTASES IN REGIONAL LYMPH NODES - RISK FACTORS FOR THE RECURRENCE OF PAPILLARY THYROID CANCER IN CHILDREN AND ADOLESCENTS
Authors: Fridman Mikhail , Mankovskaya Svetlana , Krasko Olga
Published: November 2020

Among the factors determining the relapse/persistence of papillary thyroid cancer in children and adolescents the most important are the age of the patient (p= 0.003), the presence of concomitant background pathology (p
LOCAL COMPLICATIONS OF RADIATION AND CHEMOTHERAPY TREATMENT OF PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE MUCOSA OF THE ORAL CAVITY
Authors: Kochurova Yekaterina , Mukhanov Aleksandr
Published: November 2020

Question on comprehensive dental care to patients with squamous cell carcinoma (SCC) of the mucous membrane of the oral cavity (MMOC) showed the importance of a team approach of physicians of allied specializations, careful planning and consistent implementation of rehabilitation treatment stages of cancer. The implementation of preventive measures showed a reduced severity or absence of complications conducted by the primary treatment. The data about the important role of preoperative sanitation of the oral cavity are presented. There are described the pathogenesis of the most common complications and identified effective methods of prevention and treatment, as well as the mechanisms of action of different prevention methods. Characteristic signs of “radiation caries”, oral mucositis, dysgeusia, xerostomia, lockjaw chewing muscles, osteoradionecrosis, dysphagia and neurotoxic effects of chemotherapy drugs are marked. It is necessary to emphasize the considerable effect of such complications on quality of life of patients after treatment. This again proves a need for an integrated approach and participation in the work of the specialists of a number of related disciplines.
ROLE OF ADJUVANT DRUG THERAPY IN COMBINED TREATMENT FOR CHOLANGIOCELLULAR CARCINOMA
Authors: Kovalenko Yuriy , Kukeev Ivan , Zharikov Yuriy , Paychadze A.
Published: November 2020

Cholangiocarcinoma (CC) is the second most common malignant disease of the liver. In recent decades various methods of treatment have been introduced. Nevertheless the number of treatment options for СС is still limited. Gemcitabine and cisplatin are the standard treatment for patients with inoperable CC. The second line of chemotherapy has not yet been standardized and depends on the interaction with first-line therapy. In addition many bile cancer studies to date cannot evaluate the differential activity of therapy of different anatomical localizations along the bile tract. There is no reliable evidence of the effectiveness of adjuvant therapy. The correlation of survival increase in patients with worse prognosis when using adjuvant therapy after surgical intervention seems to be reliable. The study of the molecular profile led to a more complex understanding of the genetic changes leading to clinically expressed malignant neoplasms and the possible future differentiation by anatomical or molecular structure would be optimal for the selection of chemotherapy.
RELATIONS OF PROTEASOMAL SYSTEM WITH TUMOR STAGE IN LUMINAL BREAST CANCER
Authors: Shashova Yelena , Tarabanovskaya Natalya , Fesik Yevgeniya , Slonimskaya Yelena , Kondakova Irina
Published: November 2020

The aim of this study was to investigate characteristics of the proteasomal system in luminal breast cancer. There were included 124 patients with primary luminal breast cancer in stage Т13N0-2M0 who had not received neoadjuvant treatment. The process of lymphogenous metastasis was associated with a significant change in caspase-like activity (CL) and subunit composition of proteasomes. CL activity of proteasomes was increased in luminal A breast cancer with extensive lymphogenic metastasis (N2), while it was decreased in the luminal B subtype of cancer. It was accompanied by an increase in the composition of the proteasomal total pool subunits, regulatory and immune subunits. Decrease in CL activity of proteasomes can be poor prognostic sign which is associated with the lymphogenous invasion of the tumor process in luminal B breast cancer.
DESCRIPTION OF THE CASE OF METACHRONOUS CANCER OF THE CERVICAL ESOPHAGUS AFTER EXTIRPATION OF THE ESOPHAGUS WITH PRE-STERNUM ESOPHAGOPLASTY BY THE RIGHT HALF OF THE COLON
Authors: Kit Oleg , Kolesnikov Yevgeniy , Maksimov Aleksey , Snezhko Aleksandr , Averkin Mikhail
Published: November 2020

Repeated development of a metachronous tumor in the esophagus resected because of cancer is usually observed in later periods. The period of time between the plasticity of the esophagus and the appearance of tumor can reach several tens of years. Optimal for patients with cancer of their own esophagus after esophagoplasty is early and radical surgical treatment with an individual approach to choosing surgical tactics to achieve the possible high quality of life.
MODERN THERAPY FOR RELAPSES AND RESISTANT FORMS OF HODGKIN''S LYMPHOMA
Authors: Alekseev Sergey , Kharchenko Yevgeniya , Kuleva Svetlana , Semiglazova Tatyana
Published: November 2020

Despite the success of standard front-line chemotherapy for classical Hodgkin lymphoma in part of these patients relapse or resistance are developed. During last years standard therapeutic approach for relapse or refractory disease is still «salvage» following high-dose chemotherapy with autologous stem cell transplantation. Brentuximab vedotin made great revolution in Hodgkin’s lymphoma treatment demonstrated high efficacy not only in relapse treatment but also as consolidation after autologous stem cell transplantation in high-risk group of patients. In the era of new agents for patents with relapses following autologous stem cell transplant there are multiple treatment options including single-agent and polychemotherapy, combination chemotherapy strategies, the immunoconjugate brentuximab, checkpoint inhibitors nivolumab and pembrolizumab. Allogeneic stem cell transplantation could be considered in young patients with chemosensitive tumor in the presence of a bone marrow donor. Therapeutic choice should be always based on age, comorbidities, previous treatment, patient’s preferences and drug availability.
Mathematical studies in the 18th century, in the work of François René de Chateaubriand
Authors: Truc Jean-Paul
Published: November 2020

In the 17th century, the youngest son of a noble family would follow a career as an officer in the army or as a priest. It is not surprising that Viscount François René de Chateaubriand (1768-1848) decided to prepare the exam to join l’École navale (Naval Academy), at that time École des gardes de la Marine. In fact, he did not decide this by himself, but followed the steps of his father, Count René-Auguste de Chateaubriand, ship-owner, navigator, and merchant. In this article, we will explore the book Mémoires d’outre tombe, following the young Chateaubriand in different schools, such as the Collège de Dol and the Collège de Rennes. At that time, the mathematician Étienne Bézout (1730-1783) was the almighty examiner for the entrance to l’École Navale. The memories of Chateaubriand introduce us to the way the scholars of the year 1780 studied their “Bézout” to improve their mathematical level. Keywords: Naval Academy, Bézout
Metamorphosis of geometrical teaching in France (1950-1969)
Authors: Guitart René
Published: November 2020

The “metamorphosis” can be explained quickly as follows: it is the replacement in teaching of geometrical proofs using inspection of classical figures as segments, triangles, conics, with geometrical transformations and also algebraic calculations, by the exclusive use of calculations in linear algebra with matrices. The visual aspect in the geometric sense disappears in favor of algebraic calculation alone. The back and forth between figures and calculations are forgotten but the capacity of calculations increases. My purpose is only to provide some clarifications about the sources and conditions of such a metamorphosis in France. When and how the organization of changes of geometrical teaching had been thought? Two precautions are necessary: a distinction must be made between teaching in secondary level (students aged 14 to 18) and in tertiary level (students at the university); and this must be examined especially before the “Réforme des mathématiques modernes” [new maths]. I show that, in fact, events started almost ten years before the meeting at Royaumont in 1959, with Gustave Choquet as one of the main actors. He tried to introduce a modern teaching, with linear structures (the “royal road”), but at the same time he wanted to preserve the geometrical intuition given by experience with real objects, with several “intuitive” axiomatics. At the end, the Reform did not take this moderate direction, and it was Jean Dieudonné’s purely linear approach that was privileged, up to excess of formalizations and calculations. Hence the metamorphosis arrived, when the view of the figures was replaced by the view of equations, and worse by formalization. As a testimony I explain how under these circumstances I learned geometry in the 1960s and taught geometry at the early 1970s at the university of Paris 7. Keywords: reform of modern mathematics, geometry, teaching, France, APMEP, CIEAEM, Gustave Choquet, Jean Dieudonné, Lucienne Félix, Caleb Gattegno, Morris Kline, Georges Papy, Jean Piaget, André Revuz, Gilbert Walusinski
Walking through the history of geometry teaching by Cevian and orthic triangles and quadrilaterals
Authors: Adesso Maria Giuseppina , Capone Roberto , Fiore Oriana , Tortoriello Francesco Saverio
Published: November 2020

The history of geometry teaching in Italy, in the period from the final years of the 19th century to the first half of the 20th century, is analysed here, taking into account the influence of both school reforms and the “New geometry of the triangle”, first introduced in France in 1873. Specifically, we refer to some theorems, about Cevian and orthic triangles, which may be included in the “New geometry of the triangle”, although they have been discovered in Italy before 1873. Some Italian booklets and textbooks have been analysed, to show the influence of these factors on the geometric teaching. Keywords: geometry teaching, New geometry of the triangle, Ceva’s theorem, orthic triangles, Cevian quadrilaterals, Fagnano’s problem
IMPLEMENTASI MODEL PROJECT BASED LEARNING PADA SISWA SD NEGERI 7 WONOGIRI
Authors: Mulyati Sri
Published: November 2020

This study aims to describe the improvement of learning outcomes in grouping building spaces using a project-based learning model for grade 1A students at SD Negeri 7 Wonogiri semester 1.The subjects of this classroom action research were grade 1A SD students. Negeri 7 Wonogiri, totaling 29 students, consisting of 16 male students and 13 female students. The research was conducted in semester 1. Data collection about the quality of the learning process using observation instruments, and data about learning outcomes using learning outcome test instruments. The data analysis used an interactive descriptive analysis model. The research was conducted in two cycles, each cycle consisting of planning, action, observation and reflection stages. The results showed that there was an increase in the completeness of learning outcomes to recognize space using various concrete objects from pre-cycle 44.83% (less), 71.41% (less) in cycle 1, and to 89.66% (good) in cycle 2, and The learning outcomes classify space shapes using various concrete objects from pre-cycle 41.03% (less), to 44.83% (less) in cycle 1, and to 82.76% (sufficient) in cycle 2.
A technique of the analysis of subjective and objective characteristics of medical services for design of quality of medical services (Voronezh state medical university of N. N. Burdenko, Voronezh, Russia) Annotation.
Authors:   Voronezh state medical university of N. N. Burdenko, Danilov A. V.
Published: November 2020

In a control system of quality of medical services the important part is assigned to estimates of results of activity of the medical organization, in particular degree of satisfaction of patients with quality of the received services. Now the question of quality of medical services is extremely relevant, a need for development of instruments of improvement of quality of services is had. Methods: The technique of measurement of satisfaction with quality of SERVQUAL provided to medical care based on provisions of GOST “Quality Management …” and a technique of expansion of functions of quality of QFD which elements are defined in GOST “Quantitative methods of improvement of processes “Six sigma are used”. Results: Approach on the basis of integration of techniques of measurement of satisfaction of consumers of medical services of SERVQUAL and expansion of function of quality of QFD which realization allows to build the House of quality is stated and to create data for carrying out design of quality of medical services. Conclusion: The conducted research allowed to create tools for elaboration of the adjusting and warning operating influences directed to demanded change of quality of medical services and, as a result, the recipients of services increasing satisfaction.
Distributed ledger technology in patient experience management
Authors:   RUDN University, Zuenkova Yu.А. , Khavtorin A. M. ,   Borlas LLC
Published: November 2020

A c t u a l i t y . The role of “patient experience” in assessing quality of medical services is growing as a global trend to value-based healthcare. Currently, only 11% of the Russian population positively assess the quality of medical services. Federal law No. 256-FZ requires all public healthcare providers to conduct an independent assessment of the provision of services, but 44% of organizations do not have such assessment, that can be caused by methodological and organizational reasons. P u r p o s e o f t h e s t u d y to evaluate the prospects for digital improvement of measuring patient satisfaction using distributed ledger technology. To analyze the literature on the topic of independent assessment of the quality of services provided by medical organizations; to analyze modern approaches to assessing patient satisfaction with healthcare providers; to assess the opportunities of improving the processes and results of satisfaction assessment using distributed ledger technology. M a t e r i a l s a n d m e t h o d s . To achieve the purpose, the authors analyzed numerous relevant Russian and foreign sources of literature. Literature review was carried out across scientific libraries as eLIBRARY, PubMed by key words. The search in open sources in Google and Yandex was used. R e s u l t s . The complexity of “patient experience” measurement, biased assessment, ambiguity of the results obtained and the difficulty of correct interpretation require more transparent methods of measuring the value of healthcare. A decentralized platform based on distributed ledge technology may become one of the possible solutions to the problem of objective assessment of patients ‘ satisfaction with the quality of medical services. Such approach allows to form an objective dynamic multi-factor rating of processes and all other components of healthcare services. Conclusion. The existing mechanisms for independent assessment of the quality of medical services need to be improved. Confidence in the results of the patient satisfaction measurement is one of core requirement. To make managerial decision evidence-based, it is important to evaluate the processes and patient experience along with results of healthcare services. Distributed ledger technology implemented as a dynamic multi-factor rating platform can be a logical solution for improving the quality of services and could become a part of a comprehensive IT ecosystem based on value-based approach.
Value orientations of the doctor as predictor of efficiency of activity of the medical organization
Authors:   Moscow Metropolitan Governance Yury Luzhkov University, Tsaranov K. N. , Klimova E. M. ,   Moscow Regional State University,   Research Institute of the Federal Penitentiary Service of Russia, Moscow, Akimov T. V. ,   CJSC «MED. СOM», Zvansky A. B. ,   Center for dental health "Mint», Tarbastaev A. G. ,   Moscow Metropolitan Governance Yury Luzhkov University
Published: November 2020

The article presents the results of an empirical study of the value orientations of dental clinic employees. It is suggested that gaps in human values are factors that influence professional activities in terms of communication (in the production team) and ultimately the profitability of the individual in the teams. The initial data is obtained from the reports of the clinic’s medical information system and the Schwartz’s Value Survey (SVS) and Portrait Values Questionnaire (PVQ). In addition, we used a retrospective analysis and a questionnaire survey. Doctors were divided into two groups based on the impact of value gaps on the share of revenue plan fulfillment (type one and type two groups). Attention is drawn to the direction of relationships in the group of the first type, all correlations of average strength are direct, in the group of type 2 – reverse. In the structure of the profile of value orientations, there are differences between the groups on the second place in importance for the respondents in the group of the first type are the value orientation (VO) “Achievement” and secondly, “Self-Direction”, third place in the group of the first type is “Benevolence”, whereas in the group of the second type of “Benevolence” in 4th place. To increase economic efficiency, managers of medical institutions need to organize activities to create cultural artifacts about the normative ideals of those values that affect the workflow, take into account the data of the employee’s value profile for optimal selection of the team composition (work shift).
Improving the technology of work of heads of therapeutic departments of Central district hospitals
Authors:   Dagestan state medical University of the Ministry of health of Russia, Gadzhiev R. S. , Agalarova L. S. ,   Dagestan state medical University of the Ministry of health of Russia
Published: November 2020

The article presents the results of studying the organization of work of heads of departments of central district hospitals (CRH) and the quality of therapeutic care for the rural population. The study was conducted in 2017–2019. on the basis of 26 Central District Hospital of the Republic of Dagestan. The quality of therapeutic care was studied through an expert assessment of 1,085 inpatient and 748 outpatient patient records. The timing of the working time spent by the heads of the departments of the Central District Hospital for 845 hours. It was found that under the current conditions the heads of departments devote up to 50.7% of their working time to the fulfillment of the main duties. Waste of time is 15.1%. In the therapeutic departments of the Central District Hospital, an untimely and complete examination of a significant part of the patients took place; treatment is not always complete and complete, there is no continuity in the examination and treatment of the patient between the clinic and the hospital. On the basis of the research materials, a set of recommendations was developed to improve the technology of work of heads of departments of the Central District Hospital and improve the quality of medical care. Experimental verification of the recommendations confirmed their effectiveness: the time spent on the main work increased from 51.2% to 72.4%, the share of time spent on organizing and managing the treatment and diagnostic process increased by 15.5%. Improving the organization of work of heads of departments during the experiment had a positive effect on the quality of medical care: the proportion of patients examined at the prehospital stage increased by 25.4%; the number of those fully surveyed increased from 58.4% to 90.3%; the number of patients who received full treatment increased by 14.7%.
New data on Neotropical Carpenter Moths of Subfamily Hypoptinae Neumoegen & Dyar, 1894 (Lepidoptera: Cossidae). III. Laberlia − a new genus from Northern and Central Andean Mountains
Authors: Yakovlev Roman V. , Naydenov Artem E. , Penco Fernando C.
Published: November 2020

The article describes a new genus, Laberlia (type species − Langsdorfia bellaria Dognin, 1911), including three species, distributed in northern and central Andes (the territory of Colombia, Ecuador, and Peru). We establish a new combination: Laberlia bellaria (Dognin, 1911) comb. nov. Two new species are described: Laberlia illapai Yakovlev, Naydenov, Penco sp. nov. (type locality − Ecuador, Morona Santiago, 55 km Road Rio Bamba-Macas) and Laberlia apusorum Yakovlev, Naydenov, Penco sp. nov. (type locality – Peru, La Libertad, Pataz prov., S of Tayabamba). The article is illustrated with images of type specimens and male genital structures, the distribution map is provided.
LA GESTION POR PROCESOS DEL INSTITUTO SUPERIOR TECNOLÓGICO CORPORATIVO EDWARDS DEMING, COMO PROPUESTA PARA LA ESTANDARIZACION DE LA CALIDAD EDUCATIVA A NIVEL SUPERIOR TECNICA-TEGNOLOGICA EN ECUADOR, Quito 2019-2020.
Authors: CARRERA ENDARA FERNANDO
Published: November 2020

Objetivo: Mostrar los avances en materia de procesos ha alcanzado el Instituto Tecnológico Corporativo Edwards Deming, y este sirva de ejemplo a otras instituciones del Ecuador.Métodos: Se realizó una intervención total a todos los departamentos del Instituto Tecnológico Corporativo Edwards Deming, se realizaron revisiones exhaustivas a cada departamento y se realizaron entrevistas y encuentros, con estos se describieron los sistemas de trabajo a través de las funciones inherentes a cada subsistema, a su vez se realizaron análisis de relaciones entre subsistemas, para así hacer la construcción del mapa de procesos del Instituto.Resultados: mejoramiento en el cumplimiento de las funciones de cada área, organizar y caracterizar cada proceso de Instituto Tecnológico Corporativo Edwards Deming, crear el mapa de procesos, y diseñar con la sistematización el inventario de procesos del instituto.Conclusiones: con la gestión por procesos se logra, ser más efectivos en las funciones laborales ya que el principio del trabajo colaborativo se pone de manifiesto y a su vez se mejora el clima laboral, también se resalta que este modelo de trabajo por proceso favorece el desempeño investigativo del Instituto Tecnológico Corporativo Edwards Deming para la innovación.
RELACIÓN DE TRASTORNOS MUSCULOESQUELÉTICOS EN ODONTÓLOGOS QUE ADOPTAN POSTURAS FORZADAS EN UN HOSPITAL DE LA CIUDAD DE QUITO
Authors: Merchán Álvarez María Isabel
Published: November 2020

Objetivos: Determinar el nivel de riesgo ergonómico por posturas forzadas y establecer la prevalencia de trastornos musculoesqueléticos en el personal odontológico en un Hospital de la ciudad de Quito. Materiales y métodos: Estudio observacional, descriptivo y de corte transversal, realizado en 12 profesionales que laboran en el departamento de Odontología. Se aplicó el método ergonómico REBA (Rapid Entire Body Assessment) para evaluar el nivel de riesgo por posturas forzadas y el Cuestionario Nórdico de Kuorinka para medir la prevalencia de trastornos musculoesqueléticos. Resultados: Los 12 odontólogos refirieron presentar al menos una molestia corporal, las más relevantes fueron; en cuello con 83%, espalda baja con 67% y mano y muñeca derecha con 42%; al realizar la valoración con la metodología REBA de las posturas forzadas en el puesto de trabajo se evidenció que las 3 posturas analizadas tenían un riesgo medio, por lo cual el nivel de acción era necesario. Conclusiones: Los trastornos musculoesqueléticos reportados en este estudio son principalmente a nivel de cuello, espalda baja y mano/muñeca derecha afectado a ambos sexos casi por igual excepto en a nivel de manos donde la afección es altamente prevalente en las mujeres. El nivel de riesgo ergonómico fue medio el cual requiere una acción necesaria a fin de evitar futuras repercusiones en la salud laboral.
The Association of Overt and Subclinical Hyperthyroidism with the Risk of Cardiovascular Events and Cardiovascular Mortality: Meta-Analysis and Systematic Review of Cohort Studies
Authors: Sohn Seo Young , Lee Eunyoung , Lee Min Kyung , Lee Jae Hyuk
Published: November 2020

Background: Whether hyperthyroidism is an independent risk factor for cardiovascular events remains controversial. We aimed to evaluate the association of overt and subclinical hyperthyroidism with the risk of ischemic heart disease (IHD), stroke, heart failure, and cardiovascular mortality.Methods: Studies regarding the association between hyperthyroidism and cardiovascular events were searched on PubMed and Embase databases. The cardiovascular disease (CVD) risk was classified as high and low, based on pre-existing diseases, including history of coronary, cerebral, or peripheral artery disease; heart failure; atrial fibrillation; diabetes mellitus; or chronic kidney disease.Results: Thirty-seven cohort studies were included in this meta-analysis. The pooled hazard ratio for subjects with overt hyperthyroidism compared with the control group was 1.11 (95% confidence interval [CI], 1.03 to 1.19) for IHD, 1.35 (95% CI, 1.03 to 1.75) for stroke, and 1.20 (95% CI, 1.00 to 1.46) for cardiovascular mortality. For subjects with subclinical hyperthyroidism, the pooled hazard ratio was 1.24 (95% CI, 1.07 to 1.45) for IHD, when compared with the control group. Subgroup analysis by CVD risk showed that the risk of stroke in overt hyperthyroidism was increased in the low CVD risk group; however, these association was not observed in the high CVD risk group. Similarly, the risk of IHD in subjects with subclinical hyperthyroidism was significantly increased in the low CVD risk group.Conclusion: Overt hyperthyroidism is associated with increased risk of IHD, stroke, and cardiovascular mortality, and subclinical hyperthyroidism is associated with increased risk of IHD. These associations were particularly observed in the low risk CVD group without underlying CVD.
The Subaru HSC Galaxy Clustering with Photometric Redshift. I. Dark Halo Masses versus Baryonic Properties of Galaxies at 0.3 ≤ z ≤ 1.4
Authors: Ishikawa Shogo , Kashikawa Nobunari , Tanaka Masayuki , Coupon Jean , Leauthaud Alexie , Toshikawa Jun , Ichikawa Kohei , Oogi Taira , Uchiyama Hisakazu , Niino Yuu , Nishizawa Atsushi J.
Published: November 2020

We present the clustering properties of low-z (z ≤ 1.4) galaxies selected by the Hyper Suprime-Cam Subaru Strategic Program Wide layer over 145 deg2. The wide-field and multiwavelength observation yields 5,064,770 galaxies at 0.3 ≤ z ≤ 1.4 with photometric redshifts and physical properties. This enables the accurate measurement of angular correlation functions, and the subsequent halo occupation distribution (HOD) analysis allows us to identify the connection between baryonic and dark halo properties. The fraction of less-massive satellite galaxies at z ≲ 1 is found to be almost constant at ∼20%, but it gradually decreases beyond

. However, the abundance of satellite galaxies at z > 1 is quite small even for less-massive galaxies due to the rarity of massive centrals at high-z. This decreasing trend is connected to the small satellite fraction of Lyman break galaxies at z > 3. The stellar-to-halo mass ratios at 0.3 ≤ z ≤ 1.4 are almost consistent with the predictions obtained using the latest empirical model; however, we identify small excesses from the theoretical model at the massive end. The pivot halo mass is found to be unchanged at

at 0.3 ≤ z ≤ 1.4, and we systematically show that

is a universal pivot halo mass up to z ∼ 5 that is derived using only the clustering/HOD analyses. Nevertheless, halo masses with peaked instantaneous baryon conversion efficiencies are much smaller than the pivot halo mass regardless of redshift, and the most efficient stellar-mass assembly is thought to be in progress in

dark halos.
The Effect of Land Albedo on the Climate of Land-dominated Planets in the TRAPPIST-1 System
Authors: Rushby Andrew J. , Shields Aomawa L. , Wolf Eric T. , Laguë Marysa , Burgasser Adam
Published: November 2020

Variations in the reflective properties of the bulk material that comprises the surface of land-dominated planets will affect the planetary energy balance by interacting differently with incident radiation from the host star. Furthermore, low-mass cool stars, such as nearby M8V dwarf TRAPPIST-1, emit a significant fraction of their flux in longer wavelengths relative to the Sun in regions where terrestrial materials may exhibit additional variability in albedo. Using the Community Earth System Model, we investigate the effect of the composition of the land surface and its albedo on planetary climate in the context of spatially homogeneous, entirely land-covered planets with dry atmospheres at the orbital separation of TRAPPIST-1d, TRAPPIST-1e, and TRAPPIST-1f. We use empirically derived spectra of four terrestrial compositional endmembers (granite, calcite, aridisol, and dune sand) and a composite spectrum of TRAPPIST-1 for these simulations and compare these model outputs to an aquaplanet and several Sol-spectrum control cases. We report a difference of approximately 50 K in global mean surface temperature, variations in atmospheric rotational features, and a reduction in cross-equatorial heat transport between scenarios in which materials with higher albedo in the infrared (calcite and dune sand) were used and those with more absorptive crustal material, such as granite or dry soils. An aquaplanet TRAPPIST-1d scenario results in an unstable runaway greenhouse regime. Therefore, we demonstrate that determining the composition and albedo of continental landmasses is crucial for making accurate determinations of the climate of terrestrial exoplanets.