bluuebunny/crossref_metadata_2025 huggingface dataset:
1850-PUB: Immune Silencing of Beta Cells for Transplantation Informed by Naturally Occurring Immune-Privileged Cells
Authors: AGUDO JUDITH , SANCHEZ XAVIER
Published: June 2023

To cure Type 1 Diabetes (T1D) is necessary to restore the lost beta-cells while ensuring their long-lasting survival. This could be done by transplantation of primary or stem cell-derived islets. However, any replacement will irrevocably succumb to the same autoimmune attack that killed the original beta-cells. Moreover, a mismatch between donor cells and recipient patients adds an allo-graft rejection against transplanted cells. Thus, it is of the utmost importance to develop strategies to protect transplanted pancreatic islets from immune attack. Unfortunately, many approaches aiming at restoring tolerance by manipulating immune cells have been tested and, although safe, have shown only limited efficacy. We recently discovered the existence of immune privileged tissue-resident stem cells and found that their ability to resist direct attack by T cells was not dependent on a physical barrier. Instead, it was a cell-autonomous process that allowed cloaking from immune cells. We identified a molecular pathway that reduces antigen presentation allowing protection from T cells while preserving enough MHC class I to not trigger a Natural Killer (NK) cell response. We have exploited such molecular circuits to provide similar protection to beta-cells for transplantation. Since this mechanism of protection is cell intrinsic, changes in the immune system should not jeopardize their survival. Preliminary data engineering beta-cell-like cells demonstrated that targeting this pathway leads to protection both in the Non-Obese Diabetic (NOD) model of T1D as well as in a model of CD8+ T cell-mediated autoimmune attack against beta-cells. Here we report novel candidate genes to engineer beta-cells for transplantation that can allow them to become immune silent.

Disclosure

J.Agudo: None. X.Sanchez: None.

Funding

American Diabetes Association (1-20-ACE-08 to J.A.)
1852-PUB: The Effect of Lactic Acid Fermented Sake Lees in a NASH-HCC Mouse Model
Authors: SUZUKI HIROSHI , WATANABE KENICHI , ARUMUGAM SOMASUNDARAM , REJINA AFRIN MST. , MATSUBAYASHI YASUHIRO , SONE HIROHITO
Published: June 2023

Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by fatty liver and cirrhosis that van lead to hepatocellular carcinoma. Although NASH prevalence is increasing worldwide, no cure has yet been established. Sake-lees, which are a by-product of sake refinement, have liver-protecting properties. Lactic acid fermented sake lees (FSL) is a food made by lactic acid fermentation of lees, which are then dealcoholized. Although FSL is regarded as a pro-health supplement, whether it has hepatoprotective effects remains unclear. To address this, we used a murine model of NASH to determine whether FSL could suppress progression of the disease. FSL supplementation significantly suppressed the increase in blood glucose impeded the progression of NASH. Protein analysis revealed that FSL also attenuated the increased expression of inflammatory markers. We infer that dietary FSL has anti-inflammatory and anti-hyperglycemic effects that contribute to the inhibition of NASH progression.

Disclosure

H. Suzuki: None. K. Watanabe: None. S. Arumugam: None. M. Afrin: None. Y. Matsubayashi: None. H. Sone: Research Support; Novo Nordisk, Astellas Pharma Inc., Kyowa Kirin Co., Ltd., Taisho Pharmaceutical Holdings Co., Ltd., Ono Pharmaceutical Co., Ltd., Eisai Co., Ltd., Takeda Pharmaceutical Co., Ltd.

Funding

Japan Society for the Promotion of Science (22K17772)
1197-1198 Alman Haçlı Seferi ve Eyyûbîlerin Mücadelesi
Authors: KARAKAŞ Şehri
Published: June 2023

1197-98 Alman Haçlı Seferi, III. Haçlı Seferi’nin ardından Batı dünyası tarafından küçük bir olay olarak kabul görülmesine rağmen seferin I. Friedrich Barbarossa’nın seferinden daha küçük bir girişim olmadığı anlaşılmaktadır. I. Friedrich Barborossa’nın liderliğindeki Almanların başarısız olması üzerine Doğu’daki Alman nüfuzunu kurtarmak maksadıyla Hohensteufen Hanedanlığına mensup Friedrich’in oğlu Kutsal Roma Alman İmparatoru VI. Heinrich’in (1191-1197) önderliğinde planlanan sefer, vasalları tarafından Kudüs‘ü geri alma propagandası ile yürütüldü. Doğu’ya üç grup halinde gelen Haçlılar, Eyyûbî topraklarında tahribat yarattılar. Kendileri için kutsal bölgelerden ziyade liman ya da stratejik mevkilere saldırdılar. Ancak VI. Heinrich birliklerini Doğu’ya göndermesine rağmen kendi planladığı sefere iştirak edecek kadar uzun yaşamadı. Onun ve üzerinden çok geçmeden Kudüs-Akkâ kralının ölümüyle birleşik Eyyûbî ordusu karşısında sefer, akamete uğradı. Bu makale, Alman Haçlı Seferi’nin önemini, Batı’dan gelen ve Doğu’da yaşayan Haçlıların seferden farklı beklentilerini ve seferin Eyyûbîlere yansımasını ele almıştır.
Selçuklularda Engellilerin Devlet ve Toplumdaki Yeri
Authors: AKTAŞ Yasemin
Published: June 2023

Bireylerin fiziksel ve zihinsel yetersizliğini ifade eden engellilik hâli tarih boyunca tüm toplumlarda karşılaşılan bir durumdur. Selçuklularda da engellilerin varlığı bilinmekle birlikte bu insanlardan devlet ve toplum hayatının her alanına dâhil edilenler olmuştur. Selçuklu sultanları sağlık sorunlarını çözmek amacıyla hastaneler inşa etmiş ve tıbbî çalışmaları desteklemişlerdir. Ayrıca sosyal yardımlaşmayı sağlamak için vakıflar kurmuş ve hankâhlar inşa etmişlerdir. İhtiyaç sahibi insanlar da buralardan faydalanabilmişlerdir. Selçuklu Türkiyesi’nde Ahîlik Kurumu da kendi bünyesinde Orta Sandığı yapılanmasıyla engelli bireylerin yanında yer almıştır. Bununla birlikte sosyal hayat içerisinde himaye edilen engelli bireylerin, idarî ve siyasî yapılanma içerisinde yer almasına da imkân tanınmış, bedensel engellilik liderlik ve komutanlık yapılmasında yetersizlik olarak görülmemiştir. Bu insanlardan engeliyle isimlendirilen Çolak Bâzdâr ile Topal Fahreddin Ali gibi devlet adamları askerî faaliyetlere yön vermişlerdir. Selçuklu devletlerinde engelli bireylerle kültürel hayat içerisinde de karşılaşılmaktadır. Büyük Selçuklu Devleti’nden itibaren engelli âlimlerin yetiştiği görülmekle birlikte Türkiye Selçukluları devrinde kaleme alınan eserlerde de bedensel engellilik konusunda nakiller bulunmaktadır. Engelli bireyler, Selçuklu devletlerinde ötekileştirilmeden daima himaye edilmenin yanında siyasî ve askerî faaliyetlerin içerisinde yer alabilmiş, sosyal ve kültürel hadiselerde de varlıklarını gösterebilmişlerdir.
Ermenistan’ın Temelini Oluşturan Yapay Ermeni Vilayeti’nin Kurulmasının Tarihi Seyri
Authors: GÖKTUĞ Musa
Published: June 2023

Ermenilerin, tarihinin başlama dönemi ile ilgili çeşitli iddialar bulunmaktadır. Bu tezlerin birçoğunun ayağı yere sağlam basmasa da genel kabul gören iddiaya göre Ermeniler, önce Balkanlardan gelip Orta Doğuya yerleşmiş, daha sonra burada yüz kızartıcı bir suç işlemeleri sonucu Babil kralı tarafından kuzeye sürülmüş ve gelip Doğu Anadolu topraklarına yerleşmiştir. Burada kendilerine büyük hayallerle gerçeklerden uzak bir milli tarih inşa etmişler ve ütopik sözde “Büyük Ermenistan” iddialarını ortaya koymuşlardır. Tarihleri boyunca bağımsız bir devletleri bulunmayan Ermeniler, bölgenin güçlü imparatorluklarının yerel idari birimi olarak mevcudiyetlerini sürdürmüştür. Nihayet Selçuklular ve sonrasında Osmanlı döneminde rahatı ve yüksek refahı yakalayan Ermeniler, devlet kurmak hevesine düşmüş ve XVII. yüzyılda Avrupa devletlerinden yardım istemiş ancak umdukları desteği bulamamışlardır. Ermenilerin, sözde “Büyük Ermenistan” hayalleri ile Rusya’nın bölgedeki politikaları ve çıkarlarının üst üste düşmesi sonucu Revan’ın, 1827 yılında Ruslar tarafından işgal edilmesinin ardından 21 Mart 1828 tarihinde yapay bir Ermeni Vilayeti kurulmuştur. Rusya, Ermeni Vilayeti’ni kurarak Osmanlı-Kaçar devletlerinin ortasında bir yapay Hıristiyan siyasi yapı oluşturup hem onları birbirinden ayırmayı, hem Azerbaycan halkından, hem de Türkistan’dan koparmayı hedeflemiştir. Aynı zamanda bu vilayetin kurulmasıyla Ruslar, hem Doğu Anadolu Ermenilerini kendi taraflarına çekmeyi planlamış hem de onları yalnız kendilerinin çıkarları için kullanılacak bir halk olarak kontrol altında tutmak ve kendilerine bölgede sosyal dayanak oluşturmak istemiştir. Rusya, bu nedenle Revan, Nahçıvan ve Karabağ hanlıklarının topraklarına Kaçar ülkesinden ve Doğu Anadolu’dan Ermeni göçmenler getirip iskân ettirerek etno-demografik yapıyı kendi lehine değiştirmeye çalışmıştır. 1840 yılına gelindiğinde artık Ermenilerin siyasi gücüne ihtiyacı kalmayan Rusya, bu defa bölgede otoritesini güçlendirmek ve yerel yönetimi merkezileştirmek için Ermeni Vilayeti’ni lağvetmiştir. Ancak kurulan bu suni Hıristiyan yapı, bölgedeki Rus hâkimiyetine sosyal dayanak oluşturmayı sürdürmüş ve günümüzdeki Ermenistan’a önemli bir temel teşkil etmiştir. Bu çalışmada Güney Kafkasya bölgesi ve Batı Azerbaycan toprakları ile hiçbir tarihi bağı ve geçmişi bulunmayan Ermenilerin, tarihi ile ilgili bilgi verilerek bugünkü Ermenistan’ın kurulmasında büyük rol oynayan ve temel teşkil eden Ermeni Vilayeti’nin kurulmasının tarihi süreci incelenmiş olup, bu bağlamda Ermeni tarihinin başlangıcından, Ermeni Vilayeti’nin sonlandırıldığı 1840 yılına kadarki dönemi ele alınmıştır.
The euro-Atlantic security order and the war in Ukraine
Authors: Daehnhardt Patricia
Published: June 2023

Russia’s invasion of Ukraine has sealed the collapse of the European security order created after 1991, the end of peace and the return of war in Europe. In its place a confrontational international disorder is emerging characterized by the weakening of the rules based international order, and by the ideological crystallization between democracies and autocracies. The article assesses how both the US and the EU have responded to the war in Ukraine, all while forging a new transatlantic security architecture. While this war has already shattered the European post-cold war order, it may become the prelude to the first war of the ongoing power transition between the United States and China.
Proximity and competition: vaccine diplomacy in the Atlantic space
Authors: Soler i Lecha Eduard , Ruiz de Austri Arexolaleiba Marixe
Published: June 2023

Vaccines have suddenly been incorporated into the foreign policy toolbox of global and regional powers. This article analyses the strategies of producers and recipients of vaccines in the Atlantic space. It concludes that COVID-19 has reinforced previous trends regarding regional cooperation and global geopolitical competition. In that vein, the Atlantic space has been a laboratory for both cooperation and competition initiatives among vaccine producers and recipient countries. Although material interests have been a major driver in shaping preferences and strategies, this article suggests that symbolic and normative factors also contributed to the configuration of vaccine diplomacies of producers and recipients.
Migrant life in exceptional pandemic times. A united Europe?
Authors: Rodrigues Teresa
Published: June 2023

The pandemic accelerated some emerging drifts of change ongoing in the international system and, with it and in its wake, we moved from a VUCA to a BANI world. The COVID-19 has reshaped human mobility worldwide through the imposition of lockdowns, and also aggravated the vulnerability of some specific populations, such as the migrants. They became, in most regions of the world, even more vulnerable than they were before, especially those with an irregular status, refugees and asylum seekers. The purpose of this paper is to offer insights on the vulnerability of migrants in the context of COVID-19, focussing on the case of European countries.
Brazilian Amazonian politics and policy (2019-22) and the need for transformative change
Authors: Castro Pereira Joana
Published: June 2023

Despite its potential to transition toward a green economy, the country became an environmental villain in recent years. The anti-environmentalist and anti-indigenist administration of President Jair Bolsonaro (2019–22) partly dismantled environmental governance. The Amazon and its more-than-human populations were severely hit by Bolsonaro’s predatory agenda, which supported and legitimized the interests of the anti- -conservationist forces within economic sectors such as agribusiness and mining, and fueled organized crime and violence in the region. This paper provides an overview and analysis of Amazonian politics and policy during this period, and discusses the importance of, and possibilities for, a transformative approach to the governance of the region.
THE INFLUENCE OF TERRAIN, CLIMATIC CONDITIONS AND FACTORS ON THE ATMOSPHERIC AIR MONITORING SYSTEM, BASED ON THE IMPLEMENTATION OF EU LEGISLATION ON THE EXAMPLE OF LVIV REGION
Authors:   Department of Ecology and Natural Resources of the Lviv Regional State Administration, Kravets Ihor , Malovanyy Myroslav ,   Lviv Polytechnic National University, Tymchuk Ivan ,   Lviv Polytechnic National University, Shkvirko Oksana ,   Lviv Polytechnic National University
Published: June 2023

The article is devoted to the influence of terrain, landscapes, and meteorological conditions on the establishment of air quality monitoring points in the relevant territory of the Lviv region. The main factors affecting the distribution of the concentration of pollutants in atmospheric air during the design of air monitoring stations have been determined. It was established that the level of the surface concentration of pollutants increases with an increase in the power of the emission source, the density, and size of impurity particles, and decreases with an increase in the height and radius of the orifice of the emission source, the temperature of the emission, and the rate of release of impurities from the source.
Determinants of early Post-natal Blood Pressure among Term Healthy Babies Seen in A Tertiary Hospital in Southwest Nigeria
Authors: Ogundare Ezra O. , Taiwo Adekunle B. , Okeniyi John A.
Published: June 2023

Background: Neonatal blood pressure varies considerably in the early days of life. To correctly interpret blood pressure measurements or predict the expected blood pressure of a newborn, the factors that influence neonatal blood pressure must be taken into consideration.

This study aimed to identify the factors that influence blood pressure (BP) in the early neonatal period.

Method: This is a sub-analysis of research work on the blood pressure pattern of asphyxiated neonates and apparently healthy neonates. It is a hospital-based observational study that was conducted at the Ekiti State University Teaching Hospital [EKSUTH], Ado-Ekiti, Nigeria. 12 blood pressure readings were taken serially from each baby in the first 24 hours after birth using oscillometric device. Relationships between blood pressure and physical parameters were established using regression analysis. Differences in blood pressure with respect to gender, gestational age, weight categorization, maturity for age, socio-economic status, and civil status were established using independent t-test and analysis of variance where appropriate.

Result: 1476 blood pressure readings from 123 healthy newborns were analyzed. The mean (standard deviation) (SD) BP in mmHg on day 1 were 69.5 (6.5), 39.2 (5.1), and 49.3 (4.6) for Systolic blood pressure (SBP), Diastolic blood pressure (DBP) and Mean Arterial pressure (MAP) respectively. Systolic blood pressure showed a positive linear relationship with weight (R=0.488, P=0.000) and length (R =0.304, P= 0.001). There were also significant differences in the mean (SD) of SBP with respect to gender (P = 0.015), civil status (P = 0.023), and maternal hypertension (P = 0.043). DBP (P= 0.001) and MAP(P=0.001) also had significant differences with respect to Maternal hypertension.

Conclusion: Systolic blood pressure correlated significantly with birth weight and length. Only maternal hypertension had a significant effect on diastolic blood pressure.
Different Measurement System of Lightning
Authors: Adhikari Pitri Bhakta
Published: June 2023

Lightning phenomena is the electrical discharging phenomena. The electromagnetic radiations due to lightning, having various frequencies with different wavelengths are produced. The measurement of lightning by different method like the photography method, current measurement method, electric and magnetic field measurements method and thunder measurement methods can be used. The lightning phenomena produced the waveforms of electric and magnetic field which are the basic parameters to understand the phenomena of lightning discharges. The pair of circular flat metallic plates, separated from each other by insulating material, and are used to capture the signature and measure the electromagnetic radiations produced due to lightning. The waveforms were recorded in the hilly and mountainous country, of Nepal. These types of waveforms are observed and recorded.
Accounting for the distributions of input quantities in the procedure for the measurement uncertainty evaluation when calibrating the goniometer
Authors: Zakharov Igor , Zadorozhna Iryna , Świsulski Dariusz , Diakov Dimitar
Published: June 2023

The discords concerning the measurement uncertainty evaluation in the Guide to the Expressing of Uncertainty in Measurement (GUM) and its Supplement 1 are considered. To overcome these discords, the authors of the paper propose to use the kurtosis method and the law of the propagation of the expanded uncertainty. Using the example of the goniometer calibration, the features of accounting for the distribution laws of input quantities in the procedure for the measurement uncertainty evaluation are shown. A model for direct measurements of the value of a reference measure of the angle using a goniometer is written, the procedures for the measurement uncertainty evaluation are described, and uncertainty budgets for each of the methods are given. An example of the measurement uncertainty evaluation when calibrating a digital goniometer using a 24-sided reference prism is described. An estimate of the expanded measurement uncertainty for this example was made based on the web-based software application NIST Uncertainty Machine, which showed a good agreement with the estimates obtained by the considered methods. The technology of applying this software application for the confidence level of 0,9545, which the software lacks, is shown. The estimates of the measurement uncertainty obtained by the proposed methods, Monte Carlo method and methodology of the Guide to the Expressing of Uncertainty in Measurement are compared.
Mathematical aspects of distortion calibration for digital cameras
Authors: Stadnichuk Viacheslav , Kolobrodov Valentin
Published: June 2023

Nowadays, most human processes are automated by means of computerization. This process has not spared the automotive industry. The latest developments in this field give promise that in the near future, cars will be completely autonomous. However, before that, there is an urgent need to address a number of issues, such as increasing the angle of view for greater coverage of the road with minimal space curvature. It is known that when the angle of view increases, so does the distortion (a mismatch in geometric similarity between an object and its image). This mismatch significantly reduces the accuracy of recognition algorithms. To solve this problem, this paper proposes a calibration method for cameras. The paper deals with mathematical aspects of distortion and the method of calibration of automobile chambers, and calibration errors. The method of static calibration without the use of points at infinity using static templates is proposed. A conventional camera has a small field of view (about 80 degrees). Such angle of view does not provide full scanning of the space; as a result, some of the necessary information remains outside the field of view, which is crucial for automotive industry because road signs, pedestrians, traffic lights might be missed. Therefore, in case of car cameras, the angle of view is increased by introducing distortion aberration. In this case, the field of view increases, yet the geometric similarity between the object and its image is affected. This, in turn, can affect the accuracy of computer vision algorithms. In order to keep the field of view angle large and the similarity between the subject and the object, it is necessary to calibrate the camera. In this paper, a calibration method for wide-angle car cameras is proposed and considered.
PEMUNGUTAN PAJAK AMERIKA PADA YOUTUBER INDONESIA BERDASARKAN PERATURAN U.S. INTERNAL REVENUE CODE CHAPTER 3
Authors: Khasanah Nurul Lailia , Herawati Nurul
Published: June 2023

Tujuan Penelitian ini adalah untuk memotret penerapan pemungutan pajak penghasilan kepada YouTuber berdasarkan Peraturan U.S. Internal Revenue Code Chapter 3, menggali kepatuhan YouTuber Indonesia untuk membayar pajak berdasarkan Peraturan U.S. Internal Revenue Code Chapter 3, dan meninjau kesiapan YouTuber untuk membayar pajak penghasilan yang berlaku di Indonesia dengan peraturan yang yang hampir sama dengan peraturan U.S. Internal Revenue Code Chapter 3. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif, dengan jumlah informan sebanyak 2 (dua) orang Youtuber, dalam hal ini YouTuber yang dimaksud adalah YouTuber yang telah menjadi YouTube Program Partner (YPP) dan telah mendapat potongan pajak Amerika. Data dikumpulkan dengan cara wawancara, studi dokumentasi dan observasi non partisipan. Hasil dari penelitian ini adalah Google berkewajiban mengumpulkan data pajak dari semua YouTuber yang berada di luar Amerika Serikat, terlepas dari YouTuber memperoleh pendapatan dari pemirsa Amerika Serikat atau tidak. Pemotongan pajak yang dilakukan secara otomatis, membuat YouTuber tidak dapat menghindari potongan pajak yang diberikan oleh Amerika. Berbanding terbalik dengan pemotongan pajak yang dilakukan oleh Pemerintah Amerika, sebagian YouTuber Indonesia masih belum memahami atau mengetahui pajak penghasilan yang berlaku di Indonesia, selain itu, beberapa YouTuber yang lain, memanfaatkan peraturan pajak yang belum sempurna, untuk melakukan penghindaran pajak secara sadar dan penelitian ini, menemukan hal lain di lapangan tentang pemungutan pajak pada YouTuber, baik dari sisi pemungutan pajak Amerika, maupun sisi pemungutan pajak di Indonesia.
THE INFLUENCE OF DISTINCT TYPES OF MEDIA INTERACTION AND GENDER ON THE PRODUCTIVITY OF UNIVERSITY PUPILS AS MEASURED BY THE NUMBER OF MEANINGFUL WORDS
Authors: Winarto Agustinus Rudi
Published: June 2023

This analysis seeks to discover how the richness of meaningful words is affected by the diversity of media and gender. The two separated forms of media in computer-mediated communication, which are real names (CMR) and anonym (CMA), are connected to the production of meaningful interaction in problem-solving exchanges among pupils. Furthermore, computer-based communication has added a layer of invisibility which has caused an increase in daring word usage in conversations using computers. To assess this issue, the research will look into criminal puzzles discussed in clubs, to determine if there is any impact from the various types of media and gender variation. The research used empirical analysis methods to review the effect of different media and sex on the number of meaningful words produced by 30 participants, 20 female and 10 male. Through analysis of conversations in the conversation room, a two-way ANOVA test was administered to figure out the impact of media and gender on the number of meaningful words. The investigation presented that there was no meaningful impact of media diversity and gender on the number of words produced by students in the investigation. The data suggested that any changes in media or gender had no notable effect on productivity.
Persepsi Guru PAUD Terhadap Pentingnya Pemahaman Neurosains
Authors: Rois Dyah Nur Azizah , Nuria Anniska , Sulistiani Siska , Siregar Masyunita , Hasni Uswatul
Published: June 2023

Tujuan penelitian ini dilakukan untuk mengungkap persepsi guru pendidikan anak usia dini (PAUD) terhadap pentingnya pemahaman neurosains. Penelitian ini menggunakan jenis penelitian deskriptif kualitatif. Yaitu dengan menggunakan metode penelitian survey. Pada penelitian kualitatif fitur yang paling utama berasal dari metode kualitatif natural/nyata pada tahap wawancara dengan bantuan Google from berupa angket yang dibagikan melalui media sosial WhatsApp dan diamati hasil dari responden. Hasil penelitian menunjukan bahwa sebagian besar guru memahami apa itu neurosains dan cara untuk menstimulasi perkembangan otak anak. dari seluruh guru PAUD 26 guru PAUD di Kota Jambi ada 24 guru PAUD memahami pentingnya neurosains untuk anak usia dini. Selain dari itu terdapat 2 guru PAUD yang masih belum mengetahui dan memahami neurosains dan pentingnya neurosains untuk anak usia dini serta belum mengetahui bagaimana cara menstimulasi perkembangan otak anak.
Konstruksi Indikator Asesmen Dimensi Profil Pelajar Pancasila Fase Pendidikan Anak Usia Dini
Authors: Diputera Artha Mahindra , Yus Anita , Sipahutar Rini Juliana , Sinaga Roni
Published: June 2023

Tujuan penelitian untuk mengkonstruksi indikator yang dapat dikembangkan dari elemen dan subelemen setiap dimensi Profil Pelajar Pancasila pada Fase Pendidikan Anak Usia Dini. Metode yang digunakan studi pustaka dari berbagai sumber dokumen peraturan pemerintah, buku dan artikel ilmiah yang membahas tentang Profil Pelajar Pancasila. Hasil penelusuran menghasilkan Profil pelajar Pancasila sangat penting dalam pembentukan generasi yang memiliki karakter unggul. Dengan menginternalisasi nilai-nilai Pancasila, pelajar akan menjadi individu yang memiliki integritas tinggi, bertanggung jawab, dan mampu berkontribusi secara positif terhadap masyarakat dan bangsa. Profil pelajar Pancasila juga akan membantu melahirkan pemimpin masa depan yang berkomitmen untuk mewujudkan keadilan sosial, persatuan, dan kemajuan bangsa. Kesimpulan dalam penelitian bahwa Dimensi Beriman, Bertakwa Kepada Tuhan Yang Maha Esa, dan Berahlak Mulia terdepat 10 indikator. Dimensi Berkebhinekaan Global terddapat 11 indikator. Dimensi Bergotong Royong terdapat 7 indikator. Dimensi Mandiri terdapat 7 indikator. Dimensi Bernalar Kritis terdapat 4 indikator. Dimensi Kreatif terdapat 3 indikator
Permainan Pola Ritme Musik Berbasis Budaya Sebagai Upaya Stimulasi Kecerdasan Musikal Anak Usia 5-6 Tahun
Authors: Virganta Anada Leo
Published: June 2023

Pembelajaran bagi anak usia dini membutuhkan metode pembelajaran yang sesuai dengan kecerdasan anak. Tujuan penelitian secara umum adalah menghasilkan Metode Pembelajaran Musik Berbasis Budaya dalam Menstimulasi Kecerdasan Musikal pada Anak Usia 5-6 Tahun. Jenis penelitian ini adalah penelitian pengembangan (Research and Development). Metode pembelajaran musik diuji oleh ahli untuk menilai panduan berdasarkan instrumen tes ahli juga. Hasil penelitian ini adalah pedoman metode pembelajaran musik dapat dipahami secara jelas oleh guru dan anak menunjukkan peningkatan yang baik dalam stimulasi kecerdasan musikal dengan menggunakan model pembelajaran yang telah dikembangkan. Kebaruan dari penelitian ini adalah memproduksi dan menggunakan metode pembelajaran musik berbasis budaya lokal. Kesimpulan dari penelitian ini adalah metode pembelajaran Musik berbasis Budaya dalam menstimulasi kecerdasan musikal anak usia 5-6 tahun cocok digunakan. Saran penelitian berharap metode pembelajaran musik ini dapat digunakan dan dimanfaatkan untuk menstimulasi kecerdasan musikal anak usia dini.
Some issues of legal regulation of transplantation of anatomical materials to humans
Authors: Balynska O.M. , Zaiats O.S.
Published: June 2023

The Constitution of Ukraine established that a person, his life and health are recognized as the highest social value in our state. In addition, everyone is guaranteed the right to health care, medical assistance and health insurance. At the same time, the issue of researching the legal regime of various objects of civil legal relations, including anatomical materials, biological materials, donor organs, etc., in the conditions of updating the civil legislation of Ukraine and the intentions of recodification, taking into account their special importance, have acquired the special relevance.

Transplantation is a special method of treatment, which consists in transplanting human anatomical material from a donor to a recipient and is aimed at restoring human health. Every adult with legal capacity has the right to give written (electronic) consent or non-consent to the removal of anatomical materials from his body for transplantation and/or the manufacture of bio-implants after the determination of his condition as irreversible death (brain death or biological death) in accordance with the law. The identity of the donor should not be known to the recipient, and the identity of the recipient to the donor's family, except when the recipient and the donor are married or are close relatives.

By their legal nature, consent or non-consent to donation are acts. After all, it is legally established that they must be done in writing, in particular in electronic form, in the order determined by the Cabinet of Ministers of Ukraine. Such transactions are unilateral and are not subject to notarization, and there is no requirement to certify the authenticity of a person's signature by a notary public.

In has been concluded in the article about the expediency during the recodification of the detailed regulation of the legal regime of anatomical materials, organs, biological materials, reproductive cells, etc., with mandatory consideration of the identified problems of law enforcement and modern progress.
Some aspects of providing psychiatric aid for a person in compulsory order according to the civil procedural legislation of Ukraine
Authors: Kutsyk K.
Published: June 2023

The article examines some aspects of providing psychiatric aid for a person in compulsory order according to the civil procedural legislation of Ukraine. In particular, the current legal norms, which regulate the procedure for conducting a psychiatric examination, providing outpatient psychiatric care, and hospitalization in a psychiatric care facility in the event that a person does not gives his informed consent to this, are analyzed.An analysis of the proposed legislative initiatives in this direction was also carried out, based on the relevance of the issue of ensuring the rights of persons with signs of a mental disorders.

It has been established that providing psychiatric aid for a person in compulsory orderpredictedto a person in compliance with the Law of Ukraine «On Psychiatric Care» and in accordance with the provisions of the Civil Procedure Code of Ukraine. At the same time, consideringto certain imperfections, some of it’s norms need to be updated, which is due to the need to respect the rights of the individual, the patient, as well as the presumption of mental health.

The legislative initiatives considered in the article regarding to the optimization of civil procedural legislation, which provide for the expansion of the list of subjects of appeals to the court with an application for compulsory psychiatric examination of a person, are fully justified and expedient. However, the provisions regarding the capabilityof an opportunity to carry out a preliminary assessment of a person's mental state by a doctor with any medical specialty, as well as the extension of the deadline for considering an application for a compulsory psychiatric examination of a person, which excludes the urgency of providing psychiatric aid for a personwithouthis informed consent, are debatable.

The legislators took into account certain problematic aspects that arise in the course of civil proceedings during the consideration of the specified category of cases, however, it would be expedient to provide into the norms of the current legislation effective mechanisms for observing the confidentiality and safety of persons with signs of a mental disorder, as well as to establish the right of a person who is providedcompulsory psychiatric care (or its representative) to refuse such care.
Control of the Use of Property in the practice of the European Court of Human Rights
Authors: Semerak O.S. , Manzyuk V.V. , Zaborovskyy V.V.
Published: June 2023

The article is devoted to the study of the concept of expropriation of property in accordance with the practice of the European Court of Human Rights. In particular, such concepts as control over the use of property and confiscation of property are considered.

It was found that the provision of Article 1 of Protocol 1 to the 1950 European Convention on Human Rights consists of three separate prescriptions, in particular: the rule is of a general nature and establishes the principle of unhindered use of property; refers to deprivation of property and conditions it under certain conditions; it is recognized that the Contracting States have the right, inter alia, to control the use of property in accordance with the general interest, by applying such laws as they consider necessary for this purpose.

A state party to the Convention has the right to enact such laws as it deems necessary to control the use of property in accordance with general interests. That is, it provides an opportunity to independently judge the need for such a law. At the same time, a minimum legal framework, including an appropriate forum, must be maintained to enable those who claim that their rights have been violated to effectively assert and enforce their rights.

Any state interference with such a right must be lawful and a fair balance between private and public interests must be observed. Achieving a fair balance means that in every case involving an alleged violation of this norm, it must be established that the person does not bear an unreasonable and excessive burden because of such actions or inaction of the state. Legitimacy means that the state's intervention in property rights must be carried out by ensuring compliance with laws that must be sufficiently accessible, precise and predictable in their application.

We have come to the conclusion that any interference by the state authorities in the right to peaceful possession of one's property can be justified only if it is not only legal (taking into account the instability, in particular, of domestic laws with their negative temporal property) but also corresponds to public interests by means reasonably proportionate to the goal to be achieved.
Protection of the person’s reproductive rights in Ukraine and in the European countries
Authors: Parasiuk V. , Оnyshko О.
Published: June 2023

Reproductive rights reference to related human rights and freedoms goes to a basic right - the right to life and the continuation of the human race. They are based on the recognition of the fundamental rights of individuals and couples who independently decide the number, time intervals and possible ways of having children. Reproductive rights involve making procreative decisions in a non-discriminatory manner without interference from society, the state or any other subjects. The evolution of reproductive rights shows that at the initial stage of development it was important to identify and specify the scope and content of the basic right related to the parents' decision regarding the planned number of children and the time intervals between their births. This is a fundamental right that relates to making a decision about one's own fertility, so such rights can be defined as paternity and maternity rights.

Reproductive rights can also be perceived as a special type of freedom associated with the possibility of self-determination and the right of a given person to control all aspects of his/her health. For this reason, it is important to ensure the implementation of reproductive rights without violence and coercion. In this context, the state needs to create the national mechanisms to effectively combat forms of sexual violence, including domestic violence, sexual exploitation of women and girls, sexual slavery and exploitation, forced prostitution and sexual harassment, trafficking in women and children. Violence should not be justified by moral, cultural or religious considerations. Reproductive decisions should be made without discrimination. The possibility of free exercise of reproductive rights is especially important for women for the growth of their role in the economic and political life of society and the state. In this regard, a woman's ability to independently make decisions regarding the disposal of her own body, the birth of children or not is evaluated as a basis for the exercise of other rights by women.
Exercise and Protection of the Right to a Fair Price for the Compulsory Sale of Shares in Case of a Dominant Controlling Stake Purchase in the Conditions of Corporate Legislation Amendment.
Authors: Tsikalo V.I.
Published: June 2023

The paper deals with peculiarities of exercise and protection of the minority shareholders right to a fair price for the compulsory sale of shares by them in case of purchase of a dominant controlling stake by another shareholder (shareholders) in the conditions of corporate legislation amendment.

In the process of exercising the right to compulsory redemption of shares by the owner of a dominant controlling stake (more than 95 percent of common shares), issues arose related to the violation of the right of the remaining minority shareholders to receive a fair price for the compulsory sale of shares. The problem in exercising the right of shareholders to have their shares purchased at a fair price by the owner of a dominant controlling stake is caused by the wrong wording of Art. 95 of the Law of Ukraine "On Stock Companies" regarding the need to involve a subject of professional appraisal activity, which violates the general rule established by the law on the highest price. Thus, considering paragraph 2, part 3 of Art. 95 of the Law of Ukraine "On Stock Companies", the market value of compulsory redemption shares must always be determined by the subject of professional appraisal activity, regardless of whether the shares circulate on organized capital markets or not.

In order to overcome the obstacles to exercise of the right to a fair price for the compulsory sale of shares established by the shareholder law, it is necessary to exclude from it the provision on the mandatory involvement of an appraisal activity subject in case of an independent appraisal of the value of the partnership's shares at the request of minority shareholders who own 5 percent or more shares (in the case provided for by Article 95 of the law, more than 1 percent of the partnership's shares).

The method of protecting the right to a fair share price in case of purchase of a dominant controlling stake, developed in judicial practice, was enshrined in Art. 95 of the newly adopted Law of Ukraine "On Stock Companies". Thus, according to part 21 of this article, shareholders who believe that the mandatory sale price does not meet the requirements established by parts five to seven of this article have the right to apply to court with a demand for recovery from the claimant for compensation of the proper value of the shares, purchased from them in accordance with such claim.
Types of social services for homeless people
Authors: Mokrytska N. P.
Published: June 2023

The article examines the types of social services provided to homeless persons in accordance with the Law of Ukraine "On Social Services". On the basis of the analysis of legislative norms and scientific developments, the need to apply a comprehensive approach to the functioning of the system of providing services to homeless persons is substantiated, taking into account the state social standards, which determine the procedure for providing appropriate social services for persons who find themselves in difficult life circumstances.

It was found that homeless persons are recipients of such social services as shelter, night shelter, supported accommodation of homeless persons, social integration and reintegration, and in-kind assistance. At the same time, the legislation of Ukraine provides for the possibility of applying to homeless persons such types of social services as information and social prevention, representation of interests, social support during employment and at the workplace, representation (mediation).

Given the fact that the only social service within which emergency medical assistance is provided on the street is emergency (crisis) intervention, it is necessary to recognize homeless persons as its recipients. It is also proposed to supplement the list of social services for homeless people with social and psychological rehabilitation.

Attention is focused on the need to harmonize the provisions of Art. 17 of the Law of Ukraine «On the Basics of Social Protection of Homeless Persons and Homeless Children» and Art. 16 of the Law of Ukraine «On Social Services» regarding the types of social services provided to homeless persons. It has been proven that temporary shelter, social, medical, legal, educational, and rehabilitation services for homeless persons in the sense of the provisions of the Law of Ukraine «On Social Services» are not provided for. Therefore, it is suggested that the provisions of Art. 17 of the Law of Ukraine «On the Basics of Social Protection of Homeless Persons and Homeless Children» in the following wording: «Homeless persons have the right to social services and rehabilitation in the order and under the conditions determined by the legislation of Ukraine.»
Current issues of international legal regulation of the protection of personal data of employees
Authors: Fedocenko N. , Spitsyna H.
Published: June 2023

The article discusses the problems of protecting personal data of employees from the beginning of submitting their resumes as a job seeker to their dismissal. The authors of the article analyzed and considered the regulation of this issue in the General Regulation of Personal Data Protection. During the study of the topic of the article, the methods of structural analysis and synthesis were used to divide the received information into separate structural units and systematically combine various aspects of the information into a single structured system of presenting information regarding the features that were initiated directly by the General Regulation on the Protection of Personal Data. Special attention was also paid to the legislation of Ukraine on the protection of personal data of employees. The topic of protecting employees' personal data is relevant and timely, especially in the era of digital transformation and the growing use of technology in work processes. On the one hand, the increased use of digital tools makes the work of employees easier and faster, but it also leads to an increase in the amount of personal data that is collected and processed by the employer's company. This can become a problem for the privacy of employees who have the right to protect their personal data. On the other hand, large companies can be the target of hacker attacks that aim to steal the personal data of employees and lead to serious consequences such as the theft of identity data, financial data and other sensitive data. The authors of the article concluded about the need to introduce a separate independent institution that will act as a guarantor of personal data security.

In order to systematize and efficiently process the personal information of employees, in the conditions of globalization processes, employers or employees of the personnel department regularly use applications, programs, websites with the ability to process data arrays, including personal data of employees. Therefore, the use of modern technologies can cause considerable harm to the employee. The authors of the article investigate the mechanism of how to protect data and the regulation of the protection of this data, both from the practical application and the legal regulation of this issue.
Administrative Law: from state administration to human-centeredness
Authors: Mikhrovska M.S.
Published: June 2023

The dynamism of the legislation on which administrative law is based makes it extremely sensitive to all social changes, in particular to changes related to the direct interaction of the state and society, both positive and negative. The author draws attention to the fact that during Soviet time, administrative law became a powerful tool for influencing the consciousness of citizens, and, due to the replacement of the concept of administrative law and its basic categories, the Soviet authorities managed to transform administrative law into the system of imperative prescriptions and prohibitions. In addition, the author emphasizes that precisely because of this, administrative law was left without basic categories as such - without its own subject, purpose, and even principles.The article shows why precisely at this stage of the development of our state, we cannot and should no longer refer to the category “state administration” and use it both in legislation and in everyday life.It was noted that the main part of the legal relations, which today make up the content of administrative law, are not administrative in nature, and therefore administrative law itself can no longer be called “administrative” and “imperative”.The author emphasizes that administrative law today remains an extremely important and fundamental branch of law, which needs to be updated through the transition from the above-mentioned state administration to public administration through the transition from the concept of statecenteredness to human-centeredness.After all, it is the concept of humancenteredness, in contrast to state-centerednessthat recognizes a person, his life and health, honor and dignity as the highest social value, and his rights and freedoms determine the content and direction of the state’s activities, as required by the Basic Law of the State.