bluuebunny/crossref_metadata_2025 huggingface dataset:
Problems and directions of improving the industrial production digitalization
Authors:   Stolypin Volga Region Institute of Administration of the Russian Presidential Academy of National Economy and Public Administration, Kirilov Kirill O.
Published: September 2023

Introduction. Digitalization of the industrial sector in Russia is a priority task aimed at modernizing and optimizing production processes, improving the quality and competitiveness of products, as well as strengthening the country’s position in the world market, which makes it relevant to analyze the problems of introducing digital technologies into industrial production. Theoretical analysis. The main internal and external aspects of the industrial production digitalization that may affect its success are presented, a SWOT analysis is carried out and the advantages, disadvantages, opportunities and threats associated with the digitalization of industrial production in Russia are analyzed. Empirical analysis. The digitalization of industrial production in Russia is under the influence of the following problems: lack of digital infrastructure, lack of qualified personnel, high implementation costs, cybersecurity problems, unprepared legislation. Results. The directions for improving the digitalization of industrial production are determined. In general, the results of improving the industrial production digitalization are associated with improving the efficiency, flexibility, quality and competitiveness of the organization, as well as creating new opportunities for growth and development.
Legal regulation and organization of the activities of penitentiary institutions of the Saratov province in the late XIX – early XX centuries in the context of the implementation of the prison reform of 1879
Authors:   Saratov State University, Varfolomeev Yuri V.
Published: September 2023

Introduction. In modern conditions, several promising directions in the study of the penitentiary system of the Russian Federation are being actualized. In the context of these scientific developments, the research into the historical and legal aspects of the legislative policy of late Imperial Russia to improve the organizational structure, management bodies and functioning of institutions of the penal system has become particularly relevant. Theoretical analysis. During the modernization of the penitentiary system of Russia in the late XIX – early XX centuries, laws, circulars and instructions were adopted to improve the efficiency of the management of individual places of detention of the civil department and prison guards. The legal regulation of the penal enforcement legislation made it possible to structure and improve the activities of the management, supervision and support staff of the prison department. Еmpirical analysis. It has been revealed that purposeful activities aimed at optimizing office work, establishing a correct and monotonous order of documentation, accounting and reporting in the offices of prison castles occupied an important place in the activities of the Main Prison Administration, Prison departments of the Provincial Government in the provinces. Results. During the implementation of the prison reform in the Russian Empire in 1879, a systematic modernization of the penitentiary system in the country took place. The legal regulation of the activities played the primary role in improving the management and organization of the work of all structures of the prison department, which is documented by the materials of penitentiary institutions of the Saratov province of late XIX – early XX centuries.
RESENHA: PROTAGONISMO NEGRO NA DIÁSPORA
Authors: RODRIGUES Marcos
Published: September 2023

GLEDHILL, Sabrina. Travessias no Atlântico Negro: Reflexões sobre Booker T. Washington e Manuel Querino, Edufba, 2020. 300 p.
Analysis of production loss trough quality management tolls - Case study in am electric energy meter production industry
Authors: Justina Barai Diogismar , Vitor Pinheiro da Costa Joao , Maciel Neto Thiago , De Mattos Veroneze Gabriela , Albuquerque de Oliveira Marcelo
Published: September 2023

In the modern world, organizations need to be constantly looking for ways to improve their production processes. One way to achieve this goal is through the use of basic quality tools, which are widely used by organizations. In this work we used the check sheet, the Pareto chart, cause and effect diagram, 5W2H and FPY. This work aims to minimize the high rate of production loss in the Exat test in the production lines of a company located in the State of Amazonas that operates in the electronic sector. After the analysis it was concluded that the high failure rate in Exat is linked to high numbering / misalignment / bad contact, identifying the causes of failure and then was built and implemented action plan that decreased the rate by 34.36% compared to previous year implementation of action plan.
Multimodal Aspects of Original Rebus Stories in Slovene
Authors: Haramija Dragica , Batič Janja
Published: September 2023

The article presents the characteristics of original Slovene rebus stories that have been published in book form in the last five years. Systematically also older (original and translated) rebus stories were looked at, so we are able to suggest that the findings can be applied more generally to this particular form of reading material that has a distinctly didactic function in the learning to read or developing reading literacy phase. Our research focuses on the types of literary genre and themes that appear in rebus stories, the place of illustrations in these stories, and into the characteristics of quality rebus stories. Through the analysis of 24 rebus stories, we identified the genre and themes of these stories as well as their design aspect (the position of illustrations). Through a multimodal analysis of selected work we also identified the basic characteristics of quality rebus stories.
Tracking Multimodal Literacy in Schools: a Case Study
Authors: Komninos Nickolas
Published: September 2023

This paper presents tools which can be used to measure multimodal literacy and metasemiotic awareness in students. The results are interesting within the context of multiliteracy development both in terms of the individual student over time or in comparison to other students within a specific course, as well as when comparing data from larger cohorts for example differences in level or orientation of education, age, regional, territorial, national and so on to see patterns or strengths and weaknesses in multimodal literacy within a wider perspective.
Analisis Minat Karier Berdasarkan Teori Karier Holland Siswa Sekolah Menengah Pertama di Kabupaten Gresik
Authors: Mudhar Mudhar , Hasiana Isabella , Mufidah Elia Firda , Badiah Lutfi Isni
Published: September 2023

This study aims to analyze the career interests of junior high school students in the city of Gresik. Data collection used career interest instruments based on Holland's career theory (RIASEC) which was then developed by researchers. This research uses descriptive quantitative research. Sampling used random sampling of 476 students in SMPN Gresik city area (Sunan Giri Gresik Middle School with 88 students, Gresik 2nd Middle School with 298 students, and Gresik 15th Middle School with 90 students). The research instrument was tested for the validation and reliability of Cronbach's alpha. The results showed that the career personality type of junior high school students in Gresik district was the highest, namely the social career personality type, which was 32.8%. Next, namely the career personality type towards the conventional type as much as 18.7%. As many as 14.9% of junior high school students in Gresik district have a realistic career personality type. As many as 11.1% of junior high school students in Gresik district have the investigative career personality type. 12% of junior high school students in Gresik Regency and 10.5% of students have artistic career personality types.
Kedudukan Organ RUPS Dalam Badan Hukum Perseroan Perorangan
Authors: Prasetyo Abigail
Published: September 2023

AbstractRegulations regarding the individual companies as written in the Job Creation Act, has a new perspective of concept. Which is, the possibility to have a single shareholder in a company. However, this perception could drive a new problem, especially concerning the GMS organ, which essentially given the capacity as the policy maker within the company. The problems that would arise from shares that were only owned by a single person, also what is the role of GMS organ in this individual company will also be discussed further in this article. This article uses the normative legal research method, with a conceptual approach from theory of organs. In conclusion, it explains that there are only two organs in an individual company. While the GMS organ only relies on one which also holds the role of director. Nevertheless, it can open opportunities for the organs to make decision subjectively for the company.Keywords: GMS, Private Company, Creation Labor Act and Organ Theory.
AbstrakPengaturan mengenai Perseroan Perorangan yang diatur dalam UU Cipta Kerja, memberikan konsepsi bahwa dimungkinkannya pemegang saham tunggal dalam sebuah perseroan. Akan tetapi, keadaan demikian dapat menimbulkan permasalahan baru, khususnya menyangkut organ RUPS yang pada hakikatnya menjadi pembuat kebijakan di dalam Perseroan. Apakah permasalahan yang dapat timbul dari kepemilikan saham yang hanya dipegang oleh satu orang saja, serta bagaimana peranan organ RUPS dalam hal Perseroan Perorangan menjadi hal yang hendak dibahas lebih lanjut lama artikel ini. Untuk menjawab rumusan tersebut, Penulis menggunakan metode penelitian hukum normatif dengan pendekatan konseptual dari teori organ dalam badan hukum. Pada akhirnya, Penulis menyimpukan bahwa dalam Perseroran Perorangan organ RUPS yang hanya bertumpu pada satu pemegang saham, secara otomatis merangkap kedudukannya sebagai direksi juga. Oleh karenanya, resiko terkait peluang penyalahgunaan kekuasaan dalam menentukan kebijakan menjadi sangat subjektif.Kata Kunci: RUPS, Perseroan Perorangan, UU Cipta Kerja dan Teori Organ.
Keterlambatan Pendaftaran Perubahan Data Perseroan Terbatas Kepada KEMENKUMHAM
Authors: Widodo Hana , Patricia Inge Felany  , Aurellia Tiffany
Published: September 2023

AbstractThe presence of a Limited Liability Company as a means of economic activity in everyday life can no longer be ignored. In the establishment of a Limited Liability Company, it is certain that data changes will occur as stipulated in Article 8 paragraph (1) of Regulation of the Minister of Law and Human Rights Number 21 of 2021 concerning Registration of Establishment, Amendment, Dissolution of Limited Liability Company Legal Entities, and must be registered with the Minister and declared in the notary deed. However, Limited Liability Companies often forget to register these changes. Therefore, this research will discuss the legal consequences and legal remedies for delays in registering changes to Limited Liability Company data to the Ministry of Law and Human Rights. To answer these problems the research method used is normative research using a statutory approach and a conceptual approach.Keywords: Limited liability company; Data change; Affirmation Deed.
AbstrakKehadiran Perseroan Terbatas sebagai sarana kegiatan ekonomi dalam kehidupan sehari-hari tidak lagi dapat diabaikan. Didalam pendirian Perseroan Terbatas, sudah pasti terjadi perubahan data seperti yang diatur didalam Pasal 8 ayat (1) Peraturan Menteri Hukum dan Hak Asasi Manusia Nomor 21 Tahun 2021 Tentang Pendaftaran Pendirian, Perubahan, Pembubaran Badan Hukum Perseroan Terbatas, dan harus didaftarkan ke Menteri dan dinyatakan didalam akta notaris. Namun Perseroan Terbatas seringkali lupa dalam mendaftarkan perubahan tersebut. Oleh karena itu, penelitian ini akan membahas terkait akibat hukum dan upaya hukum atas keterlambatan pendaftaran perubahan data Perseroan Terbatas kepada Kementerian Hukum dan Hak Asasi Manusia. Untuk menjawab permasalahan tersebut metode penelitian yang digunakan adalah penelitian normatif dengan menggunakan pendekatan perundang-undangan (statue approach) dan pendekatan konseptual (conseptual approach).Kata Kunci: Perseroan Terbatas; Perubahan Data; Akta Penegasan.
Upaya Hukum Bagi Anggota Yang Dirugikan Dalam Praktik Skema Piramida Bermotif Sistem Penjualan Langsung Yang Dilakukan PT Kam And Kam Melalui Aplikasi Memiles
Authors: Pusparani Melati Ayu
Published: September 2023

AbstractThis study aims to identify the legal standing of the parties in the business activities of PT Kam and Kam through the Memiles application and analyze the legal enforcement that can be taken by disadvantaged members, either through private law enforcement or consumer protection legal remedies. Pyramid schemes and direct selling are very intricate to distinguish so that people are often deceived and disadvantaged by this modus operandi. In the mid digital era, pyramid schemes have spread to the sector of services, where this has not been specifically regulated in the Act. This study concludes that in law enforcement against pyramid scheme cases in the service sector there is a vacuum of law because the services as an object are not yet regulated in the elements of the normalization of Articles governing pyramid schemes and direct selling. This legal issue will potentially open up the door for similar cases in Indonesia. Keywords: Pyramid Scheme; Direct Selling; Legal Protection; Private Law Enforcement; Consumer Protection; MeMiles.
AbstrakPenelitian ini bertujuan untuk mengidentifikasi kedudukan hukum para pihak dalam kegiatan usaha PT Kam and Kam melalui aplikasi Memiles serta menganalisis upaya hukum yang dapat dilakukan oleh anggota yang dirugikan baik melalui upaya hukum keperdataan maupun upaya hukum perlindungan konsumen. Skema piramida dan sistem penjualan langsung pada praktiknya sangat sulit untuk dibedakan karena keduanya memiliki kesamaan karakteristik, sehingga kerap kali masyarakat awam terkecoh dan dirugikan akan modus operandi ini. Di era digital ini media yang digunakan dalam menjalankan praktik skema piramida sudah merambat ke sektor jasa dimana hal ini secara spesifik belum diatur dalam Undang-Undang. Penelitian ini menyimpulkan bahwa dalam penegakan hukum terhadap kasus skema piramida di sektor jasa terdapat kekosongan hukum, sebab tidak diaturnya objek jasa dalam unsur penormaan Pasal yang mengatur mengenai skema piramida dan penjualan langsung. Isu hukum ini akan berpotensi membuka pintu masuk bagi kasus-kasus praktik skema piramida serupa di Indonesia.Kata Kunci: Skema Piramida; Penjualan Langsung; Perlindungan Hukum; Upaya Hukum Keperdataan; Perlindungan Konsumen; MeMiles.
Study of lignans in wine originating from different types of oak barrels
Authors: Vidlar Milos , Dadakova Katerina , Kasparovsky Tomas , Baron Mojmir , Průšová Božena , Sochor Jiri
Published: September 2023

This study aimed to determine the concentrations of the lignans pinoresinol, secoisolariciresinol, matairesinol and isolariciresinol in white wines aged in twelve different oak barrels originating from different cooperages and regions and with different toasting levels. In a two-year experiment the influence of oak barrels and of variety on lignan content was monitored. The results of this study show that the use of oak barrels affects only syringaresinol concentrations. Wines from low-releasing barrels contained mean concentrations of 20-50 ng/ml of syringaresinol, while wines from high-releasing barrels contained mean concentrations of 140-160 ng/ml of syringaresinol. Wines from the other barrels contained mean concentrations of 70-100 ng/ml of syringaresinol. The amounts of matairesinol and pinoresinol were affected by grapevine cultivar. In Veltliner Grün, the mean matairesinol concentration was significantly higher than in all other cultivars except for Chardonnay (mean concentrations 11, 6 and 3-5 ng/ml in Veltliner Grün, Chardonnay and other cultivars respectively). The amounts of isolariciresinol and secoisolariciresinol and total amount of lignan aglycones were affected by the interaction of cultivar and year. The mean concentrations of both lignans and total aglycone were significantly higher in Chardonnay from 2017 (210, 120 and 460 ng/ml for isolariciresinol, secoisolariciresinol and total aglycones respectively) than in all the other samples (60-130, 0-50 and 180-280 ng/ml for isolariciresinol, secoisolariciresinol and total aglycones respectively).
ANÁLISE DO PERFIL EPIDEMIOLÓGICO DA TIREOTOXICOSE NO BRASIL DE 2013 A 2022
Authors: Guimarães Moreira Dilenya , Araújo Rodrigues Júnior Valter
Published: September 2023

Introdução – Tireotoxicose refere-se a síndrome clinica decorrente do excesso de hormônios tireoidianos circulantes, secundário a hiperfunção da glândula tireoide ou não. Essa patologia acontece pela ingestão excessiva de hormônios tireoidianos, seja iatrogênica ou na tentativa de perda de peso, caracterizando a tireotoxicose factícia; produção excessiva de hormônios tireoidianos por tecido tireoidiano ectópico, a exemplo de metástase funcionante de carcinoma folicular; inflamação subaguda da tireóide, em que ocorre destruição da glândula com liberação de hormônios pré-formados; bem como pode ser secundária a drogas como o iodo e a amiodarona. METODOLOGIA: Trata-se de um estudo epidemiológico de natureza descritiva, realizado por meio da coleta de dados anuais referentes ao período entre 2013 até 2022, no Brasil, disponibilizado pelo Sistema de Informações Hospitalares (SIH). RESULTADOS: Após analise de 10 anos, registrou-se 6.151 casos de Tireotoxicose, sendo que, adultos (20 a 59 anos) e mulheres foram os grupos maior número de internações. Ao final do período, o Sudeste foi a região com mais internações e o pais registrou uma Taxa de Mortalidade de 1,95. CONCLUSÃO: A tireotoxicose é uma condição médica caracterizada pelo excesso de hormônios tireoidianos circulantes no organismo. O diagnóstico e o tratamento precoces são essenciais para evitar complicações e melhorar a saúde geral dos pacientes afetados.

Palavras-chave: TIREOTOXICOSE. TIREÓIDE.EPIDEMIOLOGIA
EPIDEMIOLOGIA DO INFARTO AGUDO DO MIOCÁRDIO NO MUNICÍPIO DE PALMAS- TO DE 2019 A 2022
Authors: Medeiros de Melo Rycharles Rudson , Alves de Castro Neto Antônio , Ferreira de Abreu Alice , Rocha Gonçalves João Pedro , Da Silva Pin Lúcio Fernando , Leite Bitencourt Evandro
Published: September 2023

Introdução: O Infarto Agudo do Miocárdio (IAM) é caracterizado como um bloqueio do fluxo sanguíneo para uma parcela do músculo cardíaco, também conhecido como miocárdio. Com isso, pode estabelecer um quadro de lesão ou morte das células do órgão, com potenciais complicações graves e até mesmo o risco de vida do paciente. Nesse contexto, no município de Palmas-TO, essa tendência se apresenta nos últimos anos com uma incidência e prevalência crescentes e consideráveis, sendo importante a realização do estudo de análise epidemiológica do IAM na cidade. Objetivos: Realizar um estudo epidemiológico do perfil do IAM no município de Palmas entre 2019 e 2022. Metodologia: Trata-se de um estudo epidemiológico de natureza descritiva, realizado por meio da coleta de dados anuais referentes ao período entre 2019 até 20222, no município de Palmas, disponibilizado pelo Sistema de Informações Hospitalares (SIH). Resultados: Houve total de 917 internações por IAM no período analisado, sendo 640 casos somente do sexo masculino. Entretanto, as mulheres apresentaram uma Taxa de Mortalidade (TM) mais elevada, com 13 casos por cada 1000 indivíduos, em comparação aos homens, que registraram uma taxa de 10,16. A faixa etária (60-69 anos) teve o maior número de casos (259), entretanto os idosos com idade entre 70 e 79 anos foram os mais afetados por óbitos. Conclusão: O estudo epidemiológico do IAM em Palmas permitiu identificar o aumento de casos na cidade e a taxa de mortalidade, com prevalência de internações em homens e óbitos em mulheres idosos (60 anos ou mais). Assim, medidas de prevenção e combate são imprescindíveis nesse cenário.
Perceptions of the importance of philanthropy according to the classification of generations based on Beresford Research
Authors: Susdarwono Endro Tri , S. Thoriqul Huda
Published: September 2023

Purpose – This study aims to describe the perception of the importance of philanthropy in today's difficult times according to the classification of generations based on Beresford. Methodology – The approach in this study uses a mixed methods research type. The research sample included 400 respondents who traveled with their destination in Pemalang Regency from December to January 2023. The sampling technique used random sampling. While the instrument used in this research is a questionnaire. The data analysis technique uses hypothesis testing on signs and independence hypothesis testing through the Khai-Square distribution. Findings – Based on the hypothesis testing steps above, it is stated that for testing the hypothesis on the sign it is concluded that philanthropy as a part of Islamic social finance is important in today's difficult conditions. As for the independence test, it was concluded that there was no influence between the grouping of generations, according to Beresford Research on the importance of philanthropy as a part of Islamic social finance in difficult times.Implications – Philanthropy is a form of programmed social generosity and is aimed at alleviating social problems (such as poverty) in the long term. Originality – The fundamental difference between this study and previous research lies in using data analysis techniques using non-parametric statistical tests. So, it has a more scientific level of testing results.
Duality Principles and Numerical Procedures for a Large Class of Non-convex Models in the Calculus of Variations
Authors: Botelho Fabio
Published: September 2023

This article develops duality principles and numerical results for a large class of non-convex variational models. The main results are based on fundamental tools of convex analysis, duality theory and calculus of variations. More specifically the approach is established for a class of non-convex functionals similar as those found in some models in phase transition. Finally, in the last section we present a concerning numerical example and the respective software.
Contraction of the Schwarzschild Horizon in Radially Falling Frames
Authors: Laforet Christopher
Published: September 2023

A new coordinate system based on the proper times of rest frames in the Schwarzschild metric is developed to show that a radially falling worldline becomes light-like at the event horizon in the Schwarzschild metric. This system has no coordinate singularity at the event horizon and light travels on 45 degree lines everywhere in the space. The light-like nature of the worldline is confirmed by analyzing it in Kruskal-Szekeres (KS) coordinates. It is shown that the worldline in KS coordinates has an undefined derivative at the horizon at any point other than the origin of the KS coordinates. It is then demonstrated that the origin of the KS coordinate system can be reached in the falling frame by exploiting the time symmetry of the manifold and that the falling worldline is indeed light-like there. The light-like nature of the worldline means that the horizon is length contracted to a point in the falling frame, such that the event horizon is proven to be the source of the Schwarzschild metric and the end point of gravitational collapse.
Towards the Development of A Low-Cost Solution for Wildlife Tracking using An Unmanned Aerial Platform
Authors: Ahmed Mansoor , Aqib Muhammad
Published: September 2023

Owing to the upsurge in the number of endangered species and understanding animal patterns in general as well as population demographics; the monitoring of wildlife species is an essential for the conservation and safety of animals. In order to organize and manage the reserves, the nature bequeaths to us, we need to have hands-on information of their population and food trends, conditions where they survive and other species in the ecosystem. The paper presents a vision-based approach to monitor wildlife using an aerial platform. A quad-rotor based aerial platform is used for the very first time for this purpose. Field imaging is done using a digital cellphone camera mounted on the platform to acquire video of horses in the field. Two techniques, Lucas-Kanade and Horn-Schunck methods are applied on the acquired set of images and the results are compared. Noise due to fluctuations and light conditions are minimized using Gaussian and HSV filters. Experiments show results with an absolute mean difference of 2.84 pixels and 8.50 pixels for changes in X and Y directions respectively for the two approaches.
Current Knowledge on the Role of Human Cytomegalovirus Infection, Encoded miRNAs, and Aortic Dissection.
Authors: Nappi Francesco , Avtaar Singh Sanjeet Singh , Alzamil Almothana
Published: September 2023

Aortic dissection is a clinicopathological entity caused by rupture of the intima leading to a high mortality if not treated. Over time, diagnostic and investigative methods, antihypertensive therapy, and early referrals have resulted in improving outcomes according to registry data. Some data has also emerged from recent studies suggesting a link between Human Cytomegalovirus (HCMV) infection and aortic dissection. Furthermore, the use of microRNAs have also become increasingly widespread in the literature. These have been noted to play a role in aortic dissections with elevated levels noted in studies as early as 2017. This review aims to provide a broad and holistic overview of the role of miRNAs, while studying the role of HCMV infection in the context of aortic dissections. The role of long non-coding RNAs, circular RNAs and microRNAs are explored to identify changes in expression during aortic dissections. The use of such biomarkers may one day be translated into clinical practice to allow early detection and prognostication of outcomes and drive preventative and therapeutic options in the future.
A Case of Giant Goiter Associated with Airway Stenosis Caused by Long-Term Intravenous Epoprostenol Therapy for Idiopathic Pulmonary Arterial Hypertension
Authors: Nishiura Kazuto , Nakazato Kazuhiko , Yokokawa Tetsuro , Suzuki Yoshinori , Kurosawa Yuta , Wada Kento , Shimizu Takeshi , Oikawa Masayoshi , Kobayashi Atsushi , Sugimoto Koichi , Shakespear Norshalena , Hashimoto Yuko , Takeishi Yasuchika
Published: September 2023

It has been reported that prostaglandin I2, such as epoprostenol, develops Grave's disease. A 34-year-old woman was diagnosed with idiopathic pulmonary arterial hypertension and started receiving continuous intravenous epoprostenol. Three years after starting epoprostenol, she started complaining of neck swelling and was diagnosed with Grave’s disease. Thyroid function was controlled by thiamazole and levothyroxine. Nevertheless, her thyroid gland enlargement worsened as epoprostenol dose was titrated. After 23 years of treatment with epoprostenol, she suddenly experienced respiratory failure with a giant goiter leading to airway stenosis and passed away. The autopsy confirmed a giant goiter associated with hyperthyroidism and airway stenosis. We experienced a case of idiopathic pulmonary hypertension with a giant goiter and airway stenosis after long-term intravenous epoprostenol therapy.
Parametric Optimisation of Hypersonic Re-entry Capsules with Air-Duct Systems
Authors: Al Qubeissi Mansour , Shaban Feras , Almohammadi Khalid M. , Shah Raja Mazuir R.A.
Published: September 2023

This study focuses on the aerodynamic optimization of the re-entry capsule (REC) Orion Crew Exploration Vehicle (CEV) module, evaluating its performance using computational fluid dynamics (CFD). Three different models, namely Baseline, 2-Duct, and 4-Duct, are investigated under a wide range of flow speeds, from supersonic (Ma=1.6) to hypersonic (Ma=6) regimes. Thermofluids aspects, drag coefficient, surface heat flux, and the effectiveness of the modified geometry are assessed using aerodynamic and temperature-based models. The results show that the introduction of ducts in the 2-Duct and 4-Duct models leads to an average decrease in the drag coefficient of approximately 2.1% and 2.9%, respectively, compared to the baseline model, across all Mach numbers. The maximum reduction in drag coefficient is 3.55%, observed at Ma=1.4 using the 4-Duct capsule. However, it is found that the addition of extra ducts to the model increases the maximum heat transfer rate. Specifically, the heat flux is increased by up to 69% for the 4-Duct model at Ma=6, compared to the baseline model. On average, the heat flux is increased by approximately 28.6% for all conditions. The findings indicate that the introduction of ducts in the REC model improves its aerothermodynamic performance by reducing drag but also increases the heat transfer rate on the surface.
Cold Formed Steel for Residential Construction – Design Philosophy and Durability Assessment
Authors: Tharmarajah Gobithas , Van Doren Kjell
Published: September 2023

According to a recent estimate by UN Habitat, approximately 3 billion individuals will require suitable housing by the year 2030. This staggering demand translates to the need for around 96,000 affordable housing units to be constructed each day. However, the conventional construction methods that rely on cement-based concrete and masonry are outdated, lacking innovation, efficiency, and sustainability. In light of these challenges, cold-formed steel emerges as an appealing alternative to traditional construction materials like masonry and concrete. It offers numerous advantages, including easy fabrication, lightweight properties, energy efficiency, the ability to reuse the material at the end of its service life, and a higher level of recyclability. Cold-formed steel buildings are also recognized for their superior insulation and lower energy consumption during operation. Cold-formed steel (CFS) members are created by rolling structurally sound steel sheets into the required shapes using a forming machine, without the need for heat as in the case of hot-rolled steel. While the thickness of these members can range from 0.01 mm to 7 mm, commercial construction of load-bearing walls, roof trusses, and floor joists typically utilizes steel thicknesses of 0.7 mm to 1.2 mm. This paper tries to illustrate the materials and methods employed in the construction of cold-formed steel modular buildings in Sri Lanka[1]. It delves into the material and durability characteristics of cold-formed steel, the design philosophy behind these structures, the development of the building envelope, and the energy efficiency features of the building elements. The findings of this study demonstrate that cold-formed steel buildings can be a highly sought-after alternative for residential construction, offering faster construction timelines, cost-effectiveness, and energy-efficient practices.
Iot Powered by Big Data: Architecture, Ecosystem, Applications
Authors: Alflahat Ahmad
Published: September 2023

To handle the huge amount of data generated by IoT devices, Big Data processing tools make it easier. This paper discusses the Big Data concept and its main V’s characteristics. It further describes IoT-enabling technologies; nominally cloud computing such as SaaS and PaaS. The centralization and infrastructure of Big Data systems, and how Cloud Computing gives a platform access to the data from anywhere. The paper explores IoT with big data architectural solutions for various use cases across the healthcare and transportation sectors.
Thromboembolic Events after COVID-19 Vaccination: An Italian Retrospective Real-World Safety Study
Authors: Bernardi Francesca furtura , Mascolo Annamaria , Sarno Marina , Capoluongo Nicolina , Trama Ugo , Ruggiero Rosanna , Sportiello Liberata , Fusco Giovanni Maria , Bisogno Massimo , Coscioni Enrico , Di micco Pierpaolo , Capuano Annalisa , Perrella Alessandro
Published: September 2023

Introduction: Real-world safety studies can provide important evidence on the thromboembolic risk associated with COVID-19 vaccines, considering that millions of people have been already vaccinated against COVID-19. In this study, we aimed to estimate the incidence of thromboembolic events after COVID-19 vaccination and to compare the Oxford–AstraZeneca vaccine with other COVID-19 vaccines.
Methods: We conducted a retrospective real-world safety study using data from two different data sources: the Italian Pharmacovigilance database (Rete Nazionale di Farmacovigilanza, RNF) and the Campania Region Health system (Sistema INFOrmativo saNità CampanIA, SINFONIA). From the start date of the COVID-19 vaccination campaign (December 27th, 2021) to September 27th, 2022, information on COVID-19 vaccinations and thromboembolic evets were extracted from the two databases. The reporting rate (RR) and its 95% confidence interval (95%CI) of thromboembolic events for 10,000 doses was calculated for each COVID-19 vaccine. Moreover, the odds of being vaccinated with the Oxford–AstraZeneca vaccine vs. the other COVID-19 vaccines in cases with thromboembolic events vs. controls without thromboembolic events were computed.
Results: A total of 12,692,852 vaccine doses were administered in Campania Region, of which 6,509,475 (51.28%) were in female and mostly related to the Pfizer-BioNtech vaccine (65.05%), followed by Moderna (24.31%), Oxford–AstraZeneca (9.71%), Janssen (0.91%), and Novavax (0.02%) vaccines. A total of 641 ICSRs with a COVID-19 vaccines and a vascular events were retrieved from the RNF for the Campania Region, of which 453 (70.67%) were in female. Most ICSRs reported the Pfizer-BioNtech vaccine (65.05%), followed by Oxford–AstraZeneca (9.71%), Moderna (24.31%), and Janssen (0.91%). A total of 2,451 events were reported in the ICSRs (3.8 events for ICSRs) of which 292 were thromboembolic events. The highe RRs of thromboembolic events were found with the Oxford–AstraZeneca vaccine (RR: 4.62, 95%CI: 3.50-5.99) and Janssen vaccine (RR: 3.45, 95%CI: 0.94-8.82). Thromboembolic events were associated with a higher likelihood of exposure to the Oxford–AstraZeneca vaccine compared to Pfizer-BioNtech (OR: 6.06; 95%CI: 4.22-8.68) and Moderna vaccines (OR: 6.46; 95%CI: 4.00-10.80).
Conclusion: We observed a higher reporting of thromboembolic events with viral-vector based vaccines (Oxford–AstraZeneca and Janssen) and an increased likelihood of being exposed to the Oxford–AstraZeneca vaccine compared to the mRNA vaccines (Pfizer-BioNtech and Moderna) among thromboembolic cases.
Osmotic Demyelination Syndrome: A Rare Clinical Image
Authors: Koul Prishita , Harjpal Pallavi , Raghumahanti Raghuveer
Published: September 2023

The term "Osmotic Demyelination Syndrome" (ODS) is synonymous with central pontine myelinolysis (CPM), denoting a condition characterized by brain damage, particularly affecting the white matter tracts of the pontine region. This damage arises due to rapid correction of metabolic imbalances, primarily cases of hyponatremia. Noteworthy triggers encompass severe burns, liver transplantations, anorexia nervosa, hyperemesis gravidarum, and hyperglycaemia, all linked to the development of CPM. Clinical manifestations encompass a spectrum of signs and symptoms, including dysphagia, dysarthria, spastic quadriparesis, pseudobulbar paralysis, ataxia, lethargy, tremors, disorientation, catatonia, and, in severe instances, locked-in syndrome and coma. A recent case involving a 45-year-old woman illustrates these complexities. Upon admission to the Medicine Intensive Care Unit, she presented with symptoms indicative of diminished responsiveness and bilateral weakness in upper and lower limbs. Of significance, the patient had a pre-existing medical history of hyperthyroidism. Extensive diagnostic investigations were undertaken, revealing compelling evidence of profound hyponatremia through blood analyses. Furthermore, magnetic resonance imaging (MRI) was performed, unveiling conspicuous areas of abnormal hyperintensity located in the central pons, intriguingly accompanied by spared peripheral regions. These radiological findings align with the characteristic pattern associated with osmotic demyelination syndrome, illuminating the underlying pathology.
Plasma Characterization and Investigation the Effect of Atmospheric Jet Plasma and DBD on PDMS Surface Hydrophobicity
Authors: Ansari Naser , Ansari Farshad
Published: September 2023

PDMS samples may be used in various microfluidic applications by hydrophilizing their surfaces. This study examines the effects of air plasma jet (APJ) and dielectric barrier discharge (DBD) plasma on the surface hydrophilicity of polydimethylsiloxane. In order to increase the hydrophilicity of PDMS sample surfaces, two plasma sources including APJ and DBD were compared. Both DBD and APJ setups were measured for voltage and current, and their respective power was calculated and compared based on their characteristics. It is important to note that the electrical specifications of APJ and DBD were identical, and the source power rates for APJ and DBD plasma were 306W and 300W respectively. UV-vis spectroscopy was used to characterize the plasma, and an electrical characterization of the plasma's power supply was carried out. The effects of parameters such as the distance from the nozzle tip, the duration of the process, and the source voltage on the hydrophilicity of the surfaces during the treatment by APJ were also examined, and samples were then examined for a period of time to determine whether surface hydrophilicity was preserved. On the PDMS surface, a contact angle of about 5.1° was observed using short-term plasma treatments of 10 seconds. In the same conditions, the effect of DBD treatment was superior to that of APJ treatment.
Inhibition of GCN2 Reveals Synergy with Cell-Cycle Regulation and Proteostasis
Authors: Gauthier-Coles Gregory , Rahimi Farid , Bröer Angelika , Bröer Stefan
Published: September 2023

The integrated stress response is a signaling network comprised of four branches, each of which senses different cellular stressors, converging on the phosphorylation of eIF2α to depress global translation and initiate recovery. One of these branches is composed of GCN2, which senses cellular amino acid insufficiency and participates in the maintenance of amino acid homeostasis. Previous studies have shown that GCN2 is a viable cancer target when amino acid stress is provoked by inhibiting an additional target. In this light, we screened a combination of drugs to identify biologically active compounds which synergize with the GCN2 inhibitor TAP20. First, a panel of 25 compounds was assayed in six cancer cell lines for drug sensitivity. Each compound was then combined with TAP20 at concentrations below their IC50, and the impact on cell growth was assessed. Selected strongly synergistic combinations were further characterised using synergy analyses and matrix-dependent invasion assays. Inhibitors of proteostasis, of the MEK-ERK pathway and pan-CDK inhibitors flavopiridol and seliciclib were found to potently synergize with TAP20 in two of the tested cell lines. Among their common CDK targets is CDK7, which was selectively targeted with THZ-1 and found to synergize with TAP20. Finally, these combinations were found to be partially synergistic when assessed using matrix-dependent invasion assays. However, we found that TAP20 alone was sufficient to restrict invasion at concentrations well below its growth-inhibitory IC50. We conclude that GCN2 can be targeted for treating cancers by polytherapy or even monotherapy.
A Topical Review on Enabling Technologies for Internet of Medical Things: Sensors, Devices, Platforms and Applications
Authors: Arefin Md , Rahman M Mostafizur , Hasan Md , Ahmed Risla , Mahmud Mufti
Published: September 2023

The Internet of Things (IoT) is still a relatively new field of research, and its potential for use in the healthcare and medical sectors is enormous. In the last five years, IoT has been a go-to option for various applications such as using sensors for different features, machine-to-machine communication, etc., but precisely, in the medical sector, it is still lagging far behind compared to other sectors. Hence, this study emphasizes the IoT applications in medical fields, Medical IoT sensors and devices, IoT platforms for data visualization, and artificial intelligence in medical applica-tions. A systematic review considering PRISMA guidelines on research articles as well as the websites on IoMT sensors and devices have been carried out. A total of 986 articles after the year 2001 have been initially selected, and by applying the inclusion-exclusion criterion, a total of 597 articles have been identified. From these, 23 studies have been finally selected for this systematic review. This review analyzes different sensor monitoring circuits in detail, considering an Inten-sive Care Unit (ICU) scenario, device applications, and the data management system, including IoT platforms for the patients. Lastly, detailed discussion and challenges have been outlined, and possible prospects have been presented.
Unveiling Neuroprotection and Regeneration Mechanisms in Optic Nerve Injury: Insight from Neural Progenitor Cell Therapy with Focus on Vps35 and Syntaxin12
Authors: Shin Hyun-Ah , Park Mira , Lee Hey Jin , Duong Van-An , Kim Hyun-Mun , Hwang Dong-Youn , Lee Hookeun , Lew Helen
Published: September 2023

Axonal degeneration resulting from optic nerve damage can lead to the progressive death of retinal ganglion cells (RGCs), culminating in irreversible vision loss. We contrasted two methods for inducing optic nerve damage: optic nerve compression (ONCo) and optic nerve crush (ONCr). These were assessed for their respective merits in simulating traumatic optic neuropathies and neurodegeneration. We also administered neural progenitor cells (NPCs) into the subtenon space to validate their potential in mitigating optic nerve damage. Our findings indicate that both ONCo and ONCr successfully induced optic nerve damage, as shown by increased ischemia and expression of genes linked to neuronal regeneration. Post NPCs injection, recovery in the expression of neuronal regeneration-related genes was more pronounced in the ONCo model than in the ONCr model, while inflammation-related gene expression saw a better recovery in ONCr. In addition, proteomic analysis of R28 cells in hypoxic conditions identified Vps35 and Syntaxin12 genes. Vps35 preserved mitochondrial function in ONCo, while Syntaxin12 appeared to restrain inflammation via the Wnt/β-catenin signaling pathway in ONCr. NPCs managed to restore damaged RGCs by elevating neuroprotection factors and controlling inflammation through mitochondrial homeostasis and Wnt/β-catenin signaling in hypoxia-injured R28 cells and in both animal models. Our results suggest that ischemic injury and crush injury cause optic nerve damage via different mechanisms, which can be effectively simulated using ONCo and ONCr, respectively. Moreover, cell-based therapies such as NPCs may offer promising avenues for treating various optic neuropathies, including ischemic and crush injuries.
The Socio-Economic Determinants of the Number of Physicians in Italian Regions
Authors: Leogrande Angelo , Costantiello Alberto , Leogrande Domenico
Published: September 2023

In the following article, we analyse the determinants of the number of physicians in the context of ISTAT BES-Benessere Equo Sostenibile data among twenty Italian regions in the period 2004-2022. We apply Panel Data with Random Effects, Panel Data with Fixed Effects, and Pooled OLS-Ordinary Least Squares. We found that the number of Physicians among Italian regions is positively associated, among others, to “Trust in the Police and Firefighters”, “Net Income Inequality”, and negatively associated, among others, to “Research and Development Intensity” and “Soil waterproofing by artificial cover”. Furthermore, we apply the k-Means algorithm optimized with the Silhouette Coefficient and we find the presence of two clusters. Finally, we confront eight different machine-learning algorithms to predict the future value of physicians and we find that the PNN-Probabilistic Neural Network is the best predictive algorithm.
Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease
Authors: Jaberi Sama , Fahnestock Margaret
Published: September 2023

Brain-derived neurotrophic factor (BDNF) is a key molecule in promoting neurogenesis, dendritic and synaptic health, and neuronal survival, plasticity, and excitability, all of which are disrupted in neurological and cognitive disorders such as Alzheimer’s disease (AD). Extracellular aggregates of amyloid-β (Aβ) in the form of plaques and intracellular aggregates of hyperphosphorylated tau protein have been identified as major pathological insults in AD brain, along with immune dysfunction, oxidative stress, and other toxic stressors. Although aggregated Aβ and tau lead to decreased brain BDNF expression, early losses in BDNF prior to plaque and tangle formation may be due to other insults such as oxidative stress and contribute to early synaptic dysfunction. Physical exercise, on the other hand, protects synaptic and neuronal structure and function, with increased BDNF as a major mediator of exercise-induced enhancements in cognitive function. Here, we review recent literature on mechanisms behind exercise induced BDNF upregulation and its effects on improving learning and memory and on Alzheimer’s disease pathology. Mechanisms include elevations in peripheral BDNF-inducing hormones such as osteocalcin, FNDC5/irisin, and lactate. The fundamental mechanisms of how exercise impacts BDNF and cognition are unclear but are a prerequisite to developing new biomarkers and therapies to delay or prevent cognitive decline.
Understanding the Intersections of IPV and HIV and Their Impact on Infant Feeding Practices: A Narrative Literature Review
Authors: Fseifes Manal Abed Elkahlik , Etowa Josephine
Published: September 2023

Intimate partner violence (IPV), particularly sexual and emotional violence, against Black mothers who acquire human immunodeficiency virus (HIV) during childbearing age is a significant health and social concern worldwide requiring targeted interventions and precautions. IPV against women increases the chances of early mixed feeding, putting infants at high risk of mother-to-child transmission of HIV and increased infant morbidities. Although violence complicates many Black mothers’ lives, there is limited research evidence about the critical intersections of violence, HIV, and Black motherhood. Women's fears associated with IPV make them less likely to disclose their positive HIV status to their partners which subsequently prevents them from using the recommended guidelines for safe infant feeding practices. This review aims to explore the critical intersections between IPV and HIV and the impact of both on the infant feeding practices of Black mothers living with HIV. Furthermore, the theme of IPV and how it overlaps with other factors such as HIV-positive status and gender dynamics to compromise the Black motherhood experience are the focus of this narrative review of existing literature. Understanding the intersection of IPV and other factors influencing infant feeding practices among women living with HIV will help inform programming and policy interventions for HIV-positive Black mothers who may be experiencing IPV during the perinatal period.