bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Organizational Culture to Supply Chain Performance by Moderating Effect of Transformational Leadership on Manufacturing Company in Riau Island Province
Authors: Laulita Nasar buntu
Published: January 2022

The purpose of this study is to know the relationship of organizational cultures to supply chain performance by moderating effect of supply chain transformational leadership style. The explanatory research was used by testing eight hypotheses for total samples from 171 manufacturing companies being represented by manager in supply chain management divisions of total 850 companies in Riau Island Province as one of region in Indonesia. SEM (Structural Equation Model) was used to analyze the data after getting primary data through questionare. The result of analyze found that: (1a) Development Culture is not significant to affect Supply Chain Performance; (1b) Transformational Leadership Style is significant to moderate relationship between Development Culture and Supply Chain Performance; (2a) Group Culture is significant to affect Supply Chain Performance and positively; (2b) Transformational Leadership Style is significant to moderate relationship between Group Culture and Supply Chain Performance; (3a) Rationale Culture is significant to affect Supply Chain Performance and positively; (3b) Transformational Leadership Style is significant to moderate relationship between Rationale Culture and Supply Chain Performance; (4a) Hierarchy Culture is significant to affect Supply Chain Performance; (4b) Transformational Leadership Style is significant to moderate relationship between Hierarchy Culture and Supply Chain Performance. The managerial implication of this research is as a guidance for decision maker in the company or manager in the supply chain management to implement suitable organizational culture and consider the effect of supply chain transformational leadership style to improve Supply Chain Performance.
CHARACTERISTIC OF AUDITOR IMPACT TO AUDIT DELAY IN COMPANY LISTED IN BURSA EFEK INDONESIA
Authors: Yopie Santi
Published: January 2022

The purpose of this study is to determine the characteristic auditor impact to audit delay. In this study the characteristic auditor is using audit committee size, audit committee meeting and audit committee expertise. The sample of this study is the companies which listed in Bursa Efek Indonesia and publish the annual report and audited report for the period of 2015-2019. Researchers used purposive sampling method, in which the research sample was not taken randomly but was based on aspects of consideration that were in accordance with the research objectives. The use of the purposive sampling method in this study was carried out by selecting companies which published annual report and audited financial report during the period year of 2015 to 2019. The research data were analyzed through multiple regression analysis using Eviews.The result of study showed that audit committee size and audit committee expertise has no significant effect to audit delay. The audit committee meeting has significant effect to audit delay. The contribution of this study is exploration the causes of audit delay for giving companies aware and prevent any audit delay which can cause costly penalty
TRAINING FOR FIRE DISASTER PREPARATION AND INITIAL MANAGEMENT OF FIRE WOUND
Authors: Wendra Wendra , Sutrisno Sutrisno , Lokarjana Lukmana , Anwar Tezza Adriansyah , N Saiful
Published: January 2022

The fire disaster preparedness training program aims to increase knowledge and abilities regarding fire alert systems, so that it is hoped that the right attitude will be in the effort to save oneself in the event of a disaster at the campus of Universitas Jenderal Achamd Yani (UNJANI). The methods used in this program are: lectures, practice/implementation, role playing, simulation, mentoring, focus group discussions (FGD) and evaluation with the support of digital technology in the context of making disaster mitigation learning materials. The solutions are: training on fire preparedness; provision of tools, facilities and infrastructure for danger signs and instructions for evacuation and rescue in the event of a fire disaster; providing educational media for campus residents about fire alertness; burn early management training.
ANALYSIS EFFECT OF SERVICE RECOVERY ON CUSTOMER LOYALTY WITH SATISFACTION AND WOM (WORD OF MOUTH) AS MEDIATION VARIABLES AT FOUR-STAR HOTELS IN BATAM CITY
Authors: Purwianti Lily , Siska Khoviati Lidya
Published: January 2022

The purpose of this study was to analyze the effect of service recovery variables consisting of distributive justice, procedural justice and interactional justice on customer loyalty with satisfaction and WOM as a mediating variable in star hotels in Batam city. The sample of this research is local tourists who have stayed at four-star hotels in Batam City. The results of the study indicate the importance of a service provider to find out what consumers want by paying attention to constructive criticism in order to improve services that were previously not adequate. If the customer feels that the service recovery provided is appropriate and satisfied with it, then the customer often returns with the status of a loyal visitor and recommends it to others.
LOYALTY AS AFFECTING MEDIATOR OF SERVICE QUALITY AND CUSTOMER SATISFACTION TOWARDS COMPETITIVE ADVANTAGE
Authors: Sultoni Mohammad Hamim , Sudarmiatin Sudarmiatin
Published: January 2022

When preparing an effective marketing strategy, a bank must consider its competitors as well as its customers. Establishing a mutual relationship with customers requires a better means of satisfying customer needs than the competitors. Micro, Small, and Medium-sized Enterprises (MSMEs) should always analyze their competitors and develop marketing strategies that effectively give the company a good position compared to the competitors and provide a competitive advantage as strong as possible. This research was conducted using a quantitative method. The design was categorized as causal relationship research. The data were then analyzed using the path analysis. Findings of the research showed that customer satisfaction, service quality, and customer loyalty affected the competitive advantage of Sentra Batik Pamekasan. The effect of customer loyalty on the competitive advantage could be observed from the number of Sentra Batik Pamekasan’s customers who decided not to move to other financial institutions (banks). When the company could give better service quality, the customer loyalty and the competitive advantage among financial institutions would get higher.
INFLUENCE OF MANAGEMENT COMMITMENT, LEADERSHIP, EMPLOYEE ENGAGEMENT, AND TRAINING ON SAFETY PERFORMANCE AT A MANUFACTURING INDUSTRY IN BATAM
Authors: Setyawan Agustinus , Nainggolan Ferdinand , Fauzi Asnil
Published: January 2022

This study is aimed to analyze the influence of management commitment, leadership, employee involvement and training to safety performance. The samples were used by this study the employees who work in the manufacturing industry of Batam island.

The method of data collection is conducted using questionnaire which distributed by google form to the companies. The sampling technique was used in this study is based on sampling of purposive. The amount of respondent is 138 questionnaires which distributed to three electronics manufacturing companies in the Muka Kuning of Batam island.

              The study shows that employee involvement and training considered siginificant a positive affect to the safety performance. But management commitment and leadership variables are not giving a significant effect to the safety performance.
ANALYSIS OF THE VARIABLES DRIVING THE E-PAYMENT INTENSITY AMONG COLLEGE STUDENTS
Authors: Yuwono Wisnu , Sari Nurtia
Published: January 2022

This study aims to analyze the influence of the variable performance expectancy, benefits, trust, self-efficacy, ease of use, and security on the use of electronic-based non-cash payment (e-payments) among students in Batam City, Riau Islands Province. The growth of e-payments in Indonesia has shown a high rate but it is still lagging behind that of several neighboring countries such as Vietnam and Thailand. Several studies on this subject have shown mixed results. By using primary data through the Smart PLS version 3.0 program tools, this study concluded that performance expectancy, benefits, self-efficacy showed a significant positive relationship with the e-payment intention, while trust, ease of use, and security showed insignificant. Based on these results, it is recommended that e-payment providers always pay attention to the needs of their users.
Pengaruh jam kerja, modal, pendidikan dan tenaga kerja terhadap pendapatan UKM sektor perdagangan di Kota Sungai Penuh
Authors: Seprianto Yogi , Zulfanetti Zulfanetti , Nurhayani Nurhayani
Published: January 2022

The purpose of this study was to determine the effect of capital, working hours, education, social and economy simultaneously on increasing income Trade Sector UKM in Sungai Penuh City and to know the social and economic development of UKM Trade sector in Sungai Penuh City. This research is a research with a quantitative approach with a population of 157 SMEs. The sampling technique used is proportionate stratified random sampling in order to obtain a total sample of 113 samples. The data collection technique used a questionnaire. Classical assumptions use normality test, multicollinearity test and heteroscedasticity test. The data analysis technique to answer the hypothesis uses multiple linear regression analysis techniques. The results of the assumptions are. Social development affects the income of trading SMEs in Sungai Penuh City. variable working hours, capital, education, and labor have a significant effect on the income of trading SMEs in Sungai Penuh City partially. The four variables, namely working hours, education capital, and labor have an effect on the income of trading SMEs in Sungai Penuh City.
Rating curve estimation using remote sensing hydraulic data and isovel contours at Karun River
Authors: Farnoush Hossein , Maghrebi Mahmoud
Published: January 2022

Determining discharge and stage-discharge curves in rivers or basins
without Hydrometric gauges is critical challenge in hydrologic studies
and river hydraulics. Researchers and designers have always been trying
to access simpler and cheaper methods to estimate discharge and rating
curves. This research aims to facilitate the determination of the
discharge and stage-discharge relationship by applying remote sensing
techniques as well as the concept of isovel contours. For this purpose,
the geometry of the river cross-section is determined using remotely
sensed data from the images of the Sentinel2 satellite, and then
discharge passed through the cross-section is estimated by the single
point velocity measurement method (SPM). The observed data were
collected from the Mollasani station in Karun River, Iran, to confirm
this method. The obtained discharges and stage-discharge relationship
curves are used to evaluate the accuracy of the proposed methodology.
Statistical analyses showed that the mean value of the percentage
error(%E) and Mean Absolute Percentage Error (MAPE) calculated based on
the difference between the estimated and observed discharges are limited
to 6.3% and %8.36, respectively. Also, the stage-discharge curves in
these studies were estimated with a maximum MAPE of 9.5%.
Prediction Model For Postoperative Severe Acute Lung Injury In Patients Undergoing Acute Type A Aortic Dissection Surgery
Authors: Wang Qiuji , Feng Weiqi , Kuang Juntao , Wu Jinlin , YANG JUE , Li Chenxi , Fan Ruixin
Published: January 2022

Objective: This study aimed to establish a risk
assessment model to predict postoperative severe acute lung injury (ALI)
risk in patients with acute type A aortic dissection (ATAAD).
Methods: Consecutive patients with ATAAD admitted to our
hospital were included in this retrospective assessment and placed in
the postoperative severe ALI and non-severe ALI groups based on the
presence or absence of ALI within 72 h postoperatively (oxygen index
(OI) ≤100 mmHg). Patients were then randomly divided into training and
validation groups in a ratio of 8:2. Logistic regression analyses were
used to statistically assess data and establish the prediction model.
The prediction model’s effectiveness was evaluated via tenfold
cross-validation of the validation group to facilitate construction of a
nomogram. Results: After screening, 479 patients were
included in the study: 132 (27.5%) in the postoperative severe ALI
group and 347 (72.5%) in the postoperative non-severe ALI group. Based
on logistics regression analyses, the following variables were included
in the model: coronary heart disease (CHD), cardiopulmonary bypass (CPB)
≥257.5 min, left atrium (LA) diameter ≥35.5 mm, hemoglobin ≤139.5 g/L,
preCPB OI ≤100 mmHg, intensive care unit (ICU) OI ≤100 mmHg, left
ventricular posterior wall thickness (LVPWT) ≥10.5 mm, and neutrophilic
granulocyte percentage (NEUT) ≥0.824. The area under the receiver
operating characteristic (ROC) curve of the modeling group was 0.805,
and differences between observed and predicted values were not deemed
statistically significant via the Hosmer–Lemeshow test (χ2=6.037, df=8,
P=0.643). For the validation group, the area under the ROC curve was
0.778, and observed and predicted value differences were insignificant
when assessed using the Hosmer–Lemeshow test (χ
=3.3782, df=7; P=0.848). The average tenfold
cross-validation score was 0.756. Conclusions: This
study established a prediction model and developed a nomogram to
determine the risk of postoperative severe ALI after ATAAD. Variables
used in the model were easy to obtain clinically and the effectiveness
of the model was good.
n-derivations of lie color algebras
Authors: Li Yizheng
Published: January 2022

The aim of this article is to discuss the n-derivation algebras of Lie color
algebras. It is proved that, if the base ring contains 1/n-1, L is a
perfect Lie color algebra with zero center, then every triple derivation of
L is a derivation, and every n-derivation of the derivation algebra nDer(L))
is an inner derivation.
Matrix LSQR algorithms for solving constrained quadratic inverse eigenvalue problem
Authors: Hajarian Masoud
Published: January 2022

The inverse eigenvalue problem appears in many applications such as control
design, seismic tomography, exploration and remote sensing, molecular
spectroscopy, particle physics, structural analysis, and mechanical system
simulation. This paper investigates the matrix form of LSQR methods for
solving the quadratic inverse eigenvalue problem with partially bisymmetric
matrices under a prescribed submatrix constraint. In order to illustrate the
effectiveness and feasibility of our results, one numerical example is
presented.
Viscosity approximation methods for quasi-nonexpansive mappings in Banach spaces
Authors: Patel Prashant , Pant Rajendra
Published: January 2022

In this article, we present viscosity approximation methods for finding a
common point of the set of solutions of a variational inequality problem and
the set of fixed points of a multi-valued quasinonexpansive mapping in a
Banach space. We also discuss some examples to illustrate facts and study
the convergence behaviour of the iterative schemes presented herein,
numerically.
Multipliers and uniformly continuous functionals over fourier algebras of ultraspherical hypergroups
Authors: Esmailvandi Reza , Nemati Mehdi
Published: January 2022

Let H be an ultraspherical hypergroup associated to a locally compact group G
and let A(H) be the Fourier algebra of H. For a left Banach A(H)-submodule X
of VN(H), define QX to be the norm closure of the linear span of the set {u
f : u ?A(H), f ? X} in BA(H)(A(H),X
Inequalities involving operator superquadratic functions
Authors: Micic Jadranka , Kian Mohsen
Published: January 2022

In this paper, related to the well-known operator convex functions, we study
a class of operator functions, the operator superquadratic functions. We
present some Jensen-type operator inequalities for these functions. In
particular, we show that f : [0,?) ? R is an operator midpoint
superquadratic function if and only if f(C*AC) ? C*f(A)C - f (?C*A2C-
(C*AC)2) holds for every positive operator A ? B(H)* and every contraction
C. As applications, some inequalities for quasi-arithmetic operator means
are given.
The n-dimensional Spanier group
Authors: Bahredar Ali , Kouhestani Nader , Passandideh Hadi
Published: January 2022

In this paper, we introduce the based and unbased n-Spanier groups and
n-semilocally simply connected spaces, and investigate their relationship.
We show that under some conditions, vanishing of the n-Spanier group with
respect to an open cover is equivalent to the n-semilocal simple
connectivity of that space, and vice versa.
On Fejér sort inequalities for products two harmonically-convex functions via fractional integrals
Authors: Baloch Madeeha , Latif Muhammad , Hussain Sabir , Saeed Muhammad
Published: January 2022

In this paper, some new estimates on Fej?r sort inequalities via Riemann
Liouville fractional integral for the products of two harmonically-convex
functions are obtained.
Nonlinear quadratic Volterra-Urysohn functional-integral equations in Orlicz spaces
Authors: Metwali Mohamed
Published: January 2022

The current article discusses the existence of monotonic discontinuous
solutions for general nonlinear quadratic Volterra-Urysohn
functional-integral equations in Orlicz spaces E? when the function ?
satisfies the ?2-condition. The case of Lebesgue spaces Lp (p > 1) are also
examined. We use the arguments of measure of noncompactness with Darbo fixed
point theorem to prove our results.
Characterization of SiO2 sol-gel coated Ti6Al4V alloy obtained by using TEOS and GPTMS
Authors: Gül Canser , Albayrak Sevda , Durmuş Hülya , Çömez Nilay
Published: January 2022

Synthesis of silicon oxide (SiO2) via the sol-gel method and SiO2 coating
ability on to Ti6Al4V alloy were investigated, in the novel study. Ti6Al4V
alloy is the most used alloy in biomedical applications due to its many
advantages. However, it has a minor disadvantage like releasing ions into
the human body. In this study, the substrate material Ti6Al4V alloy samples
were coated using the sol-gel method with alkoxysilane solutions (tetraethyl
orthosilicate, TEOS; Si(OC2H5)4 and glycidoxypropyltrimethoxysilane, GPTMS;
C9H20O5Si) containing the unit of prepared Si(OR)n after the surface
preparations were made. The prepared solutions were examined using thermal
analysis methods and the process temperatures to be applied to the coatings
were determined according to the results of the analysis. Coated samples
were subjected to aging, drying, and sintering processes at specified
temperatures. The morphologies and structures of the samples were
investigated by using a scanning electron microscope with energy-dispersive
spectroscopy (SEM-EDS) and X-ray diffraction (XRD). The sol-gel coating
ability of the silicon oxide on the surface of the Ti6Al4V alloys has been
discussed. The results demonstrate that cracks were observed in coating
produced by TEOS precursor whereas the coatings used GPTMS precursor
exhibited crack-free surface independently of dipping number. The crack
formation tended to reduce with increasing dipping number of coatings
produced by TEOS precursor. Distances between coating islets gradually
became smaller as the number of dippings increased, and the continuity of
the coatings increased. It has been observed that SiO2 coating layers
produced with GPTMS are obtained in a more continuous and crack-free form
than the layers produced with TEOS.
Processing and properties of ceramic yttrium manganite sintered by different methods
Authors: Pocuca-Nesic Milica , Marinkovic-Stanojevic Zorica , Radovic Miladin , Benitez Rogelio , Jagodic Marko , Brankovic Goran , Brankovic Zorica
Published: January 2022

Intergranular and intragranular cracks that usually form during sintering of
yttrium manganite (YMnO3) ceramic samples hinder the densification process
of this ceramic and deteriorate its magnetic and ferroelectric properties.
To overcome this problem, mechanochemically synthesized YMnO3 powder was
sintered using two different processes: Conventional Sintering (CS) and
Pulsed Electric Current Sintering (PECS). All samples were characterized by
XRD, SEM and FESEM and their magnetic and ferroelectric properties were
investigated. Apart from their phase composition, conventionally sintered
ceramic samples showed cracks throughout their whole volume, reaching a
maximum relative density of 85 %. However, it was found that PECS process
could significantly reduce the presence of cracks within samples whose
relative density reached 99.8 %.
Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory CD8 T-Cell Dysfunction
Authors: Kavazović Inga , Krapić Mia , Beumer-Chuwonpad Ammarina , Polić Bojan , Turk Wensveen Tamara , Lemmermann Niels A. , van Gisbergen Klaas P.J.M. , Wensveen Felix M.
Published: January 2022

Type 2 diabetes (T2D) causes an increased risk of morbidity and mortality in response to viral infection. T2D is characterized by hyperglycemia and is typically associated with insulin resistance and compensatory hyperinsulinemia. CD8 T cells express the insulin receptor, and previously, we have shown that insulin is able to directly modulate effector CD8 T-cell function. We therefore hypothesized that memory CD8 T-cell responsiveness in the context of T2D is negatively impacted by hyperinsulinemia or hyperglycemia. Using a mouse model for T2D, we could show that memory CD8 T-cell function was significantly reduced in response to rechallenge by viral infection or with melanoma cells. Basal insulin injection of mice increased GLUT-1 expression and glucose uptake in memory CD8 T-cell precursors early after infection, which was prevented when these cells were deficient for the insulin receptor. However, neither insulin injection nor insulin receptor deficiency resulted in a difference in metabolism, memory formation, cytokine production, or recall responses of memory CD8 T cells compared with controls. Importantly, in context of obesity, insulin receptor deficiency on CD8 T cells did not affect the functional capacity of memory CD8 T cells. In contrast, we could show in vitro and in vivo that hyperglycemia significantly impairs the antiviral capacity of memory CD8 T cells. Our findings indicate that obesity impairs the memory CD8 T-cell response against viral infection and cancer through the detrimental effects of hyperglycemia rather than hyperinsulinemia.
Methazolamide Attenuates the Development of Diabetic Cardiomyopathy by Promoting β-Catenin Degradation in Type 1 Diabetic Mice
Authors: Chen Xiaoqing , Li Yilang , Yuan Xun , Yuan Wenchang , Li Conglin , Zeng Yue , Lian Yuling , Qiu Xiaoxia , Qin Yuan , Zhang Guiping , Liu Xiawen , Luo Chengfeng , Luo Jian-Dong , Hou Ning
Published: January 2022

Methazolamide (MTZ), a carbonic anhydrase inhibitor, has been shown to inhibit cardiomyocyte hypertrophy and exert a hypoglycemic effect in patients with type 2 diabetes and diabetic db/db mice. However, whether MTZ has a cardioprotective effect in the setting of diabetic cardiomyopathy is not clear. We investigated the effects of MTZ in a mouse model of streptozotocin-induced type 1 diabetes mellitus (T1DM). Diabetic mice received MTZ by intragastric gavage (10, 25, or 50 mg/kg, daily for 16 weeks). In the diabetic group, MTZ significantly reduced both random and fasting blood glucose levels and improved glucose tolerance in a dose-dependent manner. MTZ ameliorated T1DM-induced changes in cardiac morphology and dysfunction. Mechanistic analysis revealed that MTZ blunted T1DM-induced enhanced expression of β-catenin. Similar results were observed in neonatal rat cardiomyocytes (NRCMs) and adult mouse cardiomyocytes treated with high glucose or Wnt3a (a β-catenin activator). There was no significant change in β-catenin mRNA levels in cardiac tissues or NRCMs. MTZ-mediated β-catenin downregulation was recovered by MG132, a proteasome inhibitor. Immunoprecipitation and immunofluorescence analyses showed augmentation of AXIN1–β-catenin interaction by MTZ in T1DM hearts and in NRCMs treated with Wnt3a; thus, MTZ may potentiate AXIN1–β-catenin linkage to increase β-catenin degradation. Overall, MTZ may alleviate cardiac hypertrophy by mediating AXIN1–β-catenin interaction to promote degradation and inhibition of β-catenin activity. These findings may help inform novel therapeutic strategy to prevent heart failure in patients with diabetes.
Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes
Authors: Jiang Guozhi , Luk Andrea O. , Tam Claudia H.T. , Ozaki Risa , Lim Cadmon K.P. , Chow Elaine Y.K. , Lau Eric S. , Kong Alice P.S. , Fan Baoqi ,   Hong Kong Diabetes Register TRS Study Group, Lee Ka Fai , Siu Shing Chung , Hui Grace , Tsang Chiu Chi , Lau Kam Piu , Leung Jenny Y. , Tsang Man-wo , Kam Grace , Lau Ip Tim , Li June K. , Yeung Vincent T. , Lau Emmy , Lo Stanley , Fung Samuel , Cheng Yuk Lun , Chow Chun Chung ,   Hong Kong Diabetes Biobank Study Group, Tang Nelson L.S. , Huang Yu , Lan Hui-yao , Oram Richard A. , Szeto Cheuk Chun , So Wing Yee , Chan Juliana C.N. , Ma Ronald C.W.
Published: January 2022

We aim to assess the long-term impact of acute kidney injury (AKI) on progression of diabetic kidney disease (DKD) and all-cause mortality and investigate determinants of AKI in Chinese patients with type 2 diabetes (T2D). A consecutive cohort of 9,096 Chinese patients with T2D from the Hong Kong Diabetes Register was followed for 12 years (mean ± SD age 57 ± 13.2 years; 46.9% men; median duration of diabetes 5 years). AKI was defined based on the Kidney Disease: Improving Global Outcomes (KDIGO) criteria using serum creatinine. Estimated glomerular filtration rate measurements were used to identify the first episode with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Polygenic risk score (PRS) composed of 27 single nucleotide polymorphisms (SNPs) known to be associated with serum uric acid (SUA) in European populations was used to examine the role of SUA in pathogenesis of AKI, CKD, and ESRD. Validation was sought in an independent cohort including 6,007 patients (age 61.2 ± 10.9 years; 59.5% men; median duration of diabetes 10 years). Patients with AKI had a higher risk for developing incident CKD (hazard ratio 14.3 [95% CI 12.69–16.11]), for developing ESRD (12.1 [10.74–13.62]), and for all-cause death (7.99 [7.31–8.74]) compared with those without AKI. Incidence rate for ESRD among patients with no episodes of AKI and one, two, and three or more episodes of AKI was 7.1, 24.4, 32.4, and 37.3 per 1,000 person-years, respectively. Baseline SUA was a strong independent predictor for AKI. A PRS composed of 27 SUA-related SNPs was associated with AKI and CKD in both discovery and replication cohorts but not ESRD. Elevated SUA may increase the risk of DKD through increasing AKI. The identification of SUA as a modifiable risk factor and PRS as a nonmodifiable risk factor may facilitate the identification of individuals at high risk to prevent AKI and its long-term impact in T2D.
Differentiating Microaneurysm Pathophysiology in Diabetic Retinopathy Through Objective Analysis of Capillary Nonperfusion, Inflammation, and Pericytes
Authors: An Dong , Tan Bryan , Yu Dao-Yi , Balaratnasingam Chandrakumar
Published: January 2022

Microaneurysms are biomarkers of microvascular injury in diabetic retinopathy (DR). Impaired retinal capillary perfusion is a critical pathogenic mechanism in the development of microvascular abnormalities. Targeting fundamental molecular disturbances resulting from capillary nonperfusion, such as increased vascular endothelial growth factor expression, does not always reverse the anatomic complications of DR, suggesting that other pathogenic mechanisms independent of perfusion also play a role. We stratify the effects of capillary nonperfusion, inflammation, and pericyte loss on microaneurysm size and leakage in DR through three-dimensional analysis of 636 microaneurysms using high-resolution confocal scanning laser microscopy. Capillary nonperfusion, pericyte loss, and inflammatory cells were found to be independent predictors of microaneurysm size. Nonperfusion alone without pericyte loss or inflammation was not a significant predictor of microaneurysm leakage. Microaneurysms found in regions without nonperfusion were significantly smaller than those found in regions with nonperfusion, and their size was not associated with pericyte loss or inflammation. In addition, microaneurysm size was a significant predictor of leakage in regions with nonperfusion only. This report refines our understanding of the disparate pathophysiologic mechanisms in DR and provides a histologic rationale for understanding treatment failure for microvascular complications in DR.
PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes
Authors: Elvira Bernat , Vandenbempt Valerie , Bauzá-Martinez Julia , Crutzen Raphaël , Negueruela Javier , Ibrahim Hazem , Winder Matthew L. , Brahma Manoja K. , Vekeriotaite Beata , Martens Pieter-Jan , Singh Sumeet Pal , Rossello Fernando , Lybaert Pascale , Otonkoski Timo , Gysemans Conny , Wu Wei , Gurzov Esteban N.
Published: January 2022

Type 1 diabetes (T1D) results from autoimmune
destruction of β-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are
candidate genes for T1D and play a key role in autoimmune disease development
and β-cell dysfunction. Here, we assessed the global protein and
individual PTP profiles in the pancreas from early onset non-obese diabetic
(NOD) mice treated with an anti-CD3 monoclonal
antibody and interleukin-1 receptor antagonist. The treatment reversed hyperglycemia and we observed enhanced expression
of PTPN2, a PTP family member and T1D candidate gene, and endoplasmic reticulum (ER) chaperones in the pancreatic islets. To address the functional role of PTPN2 in β-cells, we generated PTPN2-deficient human
stem cell-derived β-like and EndoC-βH1 cells. Mechanistically,
we demonstrated that PTPN2 inactivation
in β-cells exacerbates type I and type II
interferon signaling networks and the
potential progression towards autoimmunity. Moreover, we established the
capacity of PTPN2 to positively modulate the Ca2+-dependent unfolded
protein response and ER stress outcome in
β-cells. Adenovirus-induced
overexpression of PTPN2 partially protected from ER-stress induced β-cell death. Our
results postulate PTPN2 as a key protective factor in β-cells during inflammation
and ER stress in autoimmune diabetes.
Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory Cd8 T Cell Dysfunction
Authors: Kavazović Inga , Krapić Mia , Beumer-Chuwonpad Ammarina , Polić Bojan , Wensveen Tamara Turk , Lemmermann Niels A. , Gisbergen Klaas P.J.M. van , Wensveen Felix M.
Published: January 2022

Diabetes mellitus type 2 (T2D) causes an
increased risk of morbidity and mortality in response to viral infection. T2D
is characterized by hyperglycemia and is typically associated with insulin
resistance and compensatory hyperinsulinemia. CD8 T cells express the insulin
receptor and previously we have shown that insulin is able to directly modulate
effector CD8 T cell function. We therefore hypothesized memory CD8 T cell
responsiveness in context of T2D is negatively impacted by hyperinsulinemia or
hyperglycemia. Using a mouse model for T2D we could show that memory CD8 T cell
function was significantly reduced in response to re-challenge by viral
infection or with melanoma cells. Basal insulin injection of mice increased
GLUT-1 expression and glucose uptake in memory CD8 T cell precursors early
after infection, which was prevented when these cells were deficient for the
insulin receptor. However, neither insulin injection, nor insulin receptor
deficiency resulted in a difference in metabolism, memory formation, cytokine
production or recall responses of memory CD8 T cells compared to controls.
Importantly, in context of obesity, insulin receptor deficiency on CD8 T cells
did not affect the functional capacity of memory CD8 T cells. In contrast, we
could show in vitro and in vivo that hyperglycemia significantly impairs the
antiviral capacity of memory CD8 T cells. Our findings indicate that obesity
impairs the memory CD8 T cell response against viral infection and cancer
through the detrimental effects of hyperglycemia rather than hyperinsulinemia.
Use of administrative record linkage to examine patterns of universal early childhood health and education service use from birth to Kindergarten (age 4 years) and developmental vulnerability in the Preparatory Year (age 5 years) in Tasmania, Australia.
Authors: Taylor Catherine Louise , Christensen Daniel , Venn Alison , Preen David , Stafford Joel , Hansen Emily , Jose Kim , Zubrick Stephen
Published: January 2022

BackgroundIn Australia, the health and education sectors provide universal early childhood services for the same population of children. Therefore, there is a strong imperative to view service use and outcomes through a cross-sectoral lens to better understand and address the service needs of young children and their families.
ObjectivesTo investigate patterns of health and education service use from birth through Kindergarten (age four years), the associations with cumulative risks, and developmental vulnerability in the first year of full-time school (age five years).
MethodsA retrospective cohort study that used population-wide linkage of health and education administrative data records for 5,440 children with a Tasmanian 2015 Australian Early Development Census (AEDC) record who were born in Tasmania (2008-2010).
ResultsFour service use patterns were identified: Regular (46% of children), Declining (24%); Low (18%); and Selective service use (12%). Regular service use (aOR 0.8, 95% CI 0.7 to 0.9), adjusted for cumulative risks, was associated with decreased odds of developmental vulnerability, compared to the other service use groups. Low (OR 6.1, 95% CI 4.5 to 8.2) and Declining service use (OR 2.5 95% CI 1.9 to 3.4) were more likely for children with the highest levels of cumulative risks. Low and Declining service use, adjusted for cumulative risks were associated with increased odds of developmental vulnerability, compared to the Regular service use group.
ConclusionThis study provides a whole population view of the differential use of universal services and the complex risk circumstances that influence service use. The association between patterns of multiple risk and service use points to barriers to service use, and the varying level of developmental vulnerability within each service use group draws attention to children who may benefit from higher sustained participation in core health and education services across the whole of early childhood.
Next Generation Access in a Rural Community Context: An Innovation Analysis
Authors:   , Cope Sian Elizabeth
Published: January 2022

This thesis explores how to resolve the digital divide in Wales. This is important because access to advanced broadband is considered an essential requirement, particularly post-COVID19. UK Government is advocating next generation access (NGA) to capitalise on Industry 4.0. However, the financial costs and complexities of connecting the final few rural areas is a persisting problem area. Hence, this thesis explores new innovative approaches to provide NGA (product) to a final few (market). Studies revealed superfast broadband in remote rural communities has four-fold human, social, environmental and financial capital benefits. Analysis resulted in a new conceptual framework which combines neo-endogenous theories alongside a four-fold capital model to characterise the complex ecosystem. Previous literature focused on either supply or demand, but few studies had investigated both together at the local level. Human & social capital were identified as critical success factors in community-led initiatives, thus providing a theoretical underpinning for this thesis. This study employed a novel mutual business approach utilising the Hybrid Value System (HVS) as an ecosystem connecting the core assets of several stakeholders. Furthermore, the World Bank Social Capital Assessment Tool was modified to investigate social capital fertility to enhance investment. Henceforth, a qualitative multi-method and in-depth intrinsic case study was used to explore the ecosystem. The contribution to knowledge is how to engage multi-stakeholder and multi-capital analysis to resolve the problem area. The results identified human capital productivity, social capital collective action, and shared financial capital are required at the local level to reach the final few. The mutual business paradigm challenges all stakeholders to value non-financial capital alongside financial capital for problem area resolution. This thesis concludes that HVS methodology coupled with complex ecosystem-network visualisation techniques, provide academics, management and government policy makers with practical tools to value four-fold capital resources and bridge the digital divide.
A Review of The Challenges of Paperless Concept In The Society 5.0
Authors: Prasetyo S.E. , Damaraji G.M. , Kusumawardani S.S.
Published: January 2022

The world will start a new era of society where technology and humans can collaborate to solve social problems. Many countries have ridden into the 4.0 era in the industrial revolution. In reality, Japan began to introduce Society 5.0, where the concept was the answer to the industrial revolution 4.0. Society 5.0 applies the human-centered concept based on information technology. In fact, there has been no in-depth study of the advantages and challenges of implementing paperless in various fields. The purpose of this paper is to review the challenges and the advantages of the paperless concept using Narrative Literature Review to provide an objective analysis of the paperless concept. The objects research discussed including industry/manufacturing, education, medical, and government. This paper provides an in-depth study and analysis of the paperless concept's advantages and challenges related to hardware and software maintenance, data security and reliability, human resources technical skills, social interaction, and disaster recovery strategy.
Application of Pigeon Inspired Optimization for Multidimensional Knapsack Problem
Authors: Setiawan F. , Sadiyoko A. , Setiardjo C.
Published: January 2022

The multidimensional knapsack problem (MKP) is a generalization of the classical knapsack problem, a problem for allocating a resource by selecting a subset of objects that seek for the highest profit while satisfying the capacity of knapsack constraint. The MKP have many practical applications in different areas and classified as a NP-hard problem. An exact method like branch and bound and dynamic programming can solve the problem, but its time computation increases exponentially with the size of the problem. Whereas some approximation method has been developed to produce a near-optimal solution within reasonable computational times. In this paper a pigeon inspired optimization (PIO) is proposed for solving MKP. PIO is one of the metaheuristic algorithms that is classified in population-based swarm intelligent that is developed based on the behavior of the pigeon to find its home although it had gone far away from it home. In this paper, PIO implementation to solve MKP is applied to two different characteristic cases in total 10 cases. The result of the implementation of the two-best combination of parameter values for 10 cases compared to particle swarm optimization, intelligent water drop algorithm and the genetic algorithm gives satisfactory results.
O PROGRAMA NACIONAL DE FORMAÇÃO DE PROFESSORES (PARFOR) NO CONTEXTO DA RACIONALIDADE DO ESTADO MODERNO: diálogos entre as teorias de Max Weber e de Bresser-Pereira
Authors: Lins Damasceno Lorena , Rezende Vargas Adriana , Ribeiro Guimarães Mendes Daniella
Published: January 2022

Este artigo abordou a formação de professores no Brasil à luz da teoria weberiana, situando a profissão docente na esfera do modelo burocrático de administração, e dialogando com as provocações de Bresser-Pereira sobre as possibilidades de reformas do Estado, tendo como referência a perspectiva republicana. A partir das discussões desses autores, nos debruçamos sobre a configuração das políticas de formação docente delineadas a partir das reformas educacionais dos anos 1990, cujo cenário foi complexo e contraditório, especialmente no que se refere às transformações no mundo do trabalho. Abordamos, ainda, o Programa Nacional de Formação de Professores da Educação Básica (Parfor), uma política pública do governo federal que tem o objetivo de formar os docentes que já atuam nas escolas públicas, mas que ainda não possuem o diploma exigido pela Lei de Diretrizes e Bases da Educação Nacional. Entendemos que esse programa, ao tentar enquadrar esses profissionais na estrutura legal-formal do Estado Brasileiro, pode ilustrar o caráter regulador do Estado moderno na perspectiva da dominação racional, segundo a teoria de Weber.
Rating of road infrastructure and public transport in Radom according to respondents' sex and age
Authors: Dębowska-Mróz Marzenna , Rogowski Andrzej
Published: January 2022

The article presents the results of surveys on public transport and road infrastructure of Radom. There were 855 questionnaires obtained. The 19 questions of the survey were used. The survey, in addition to questions about age and gender, contained questions with specific answer options with single or multiple choice and questions in which the respondent rated the various elements of the transport system. From 8 questions, a 5-point Liekert scale was created as a basis for evaluating public transportation and road infrastructure. The reliability of the scale was assessed using the standardized Cronbach's coefficient. The analysis was done in selected groups of respondents with respect to age of respondents, gender of respondents and with respect to both characteristics simultaneously. Using the chi-square test of independence, the dependence of the scores on the age and gender of the respondents was examined. To compare the significance of differences in ratings between the separate groups of respondents, the test of significance of averages was used. The results of the survey indicate that although the overall rating is positive, due to the high percentage of negative ratings, it is necessary to take measures to improve, among other things: safety at bus stops and public transportation vehicles, availability and distribution of parking spaces. The results of the survey were compared with the results of previous surveys. Compared to the 2014 survey, a significant improvement was found in the condition of road infrastructure and the condition and distribution of bike lanes.
Comparison between Digital Panoramic Radiography and Cone-Beam Computed Tomography in Measuring Presurgical Dental Implant Vertical Height at Posterior Mandible
Authors: Ayob MAM , Md Jasin JS , Suparman MK , Reduwan NH
Published: January 2022

Objectives: This study aims to evaluate the reliability of panoramic radiograph in comparison to cone beam computed tomography for posterior mandibular pre-implant assessment. Materials and Methods: A retrospective evaluation of the panoramic (PAN) and CBCT images in complete, partially edentulous, and dentate patients was conducted on 66 cases for presurgical dental implant assessment. Assessment of the vertical bone height was conducted by dividing the posterior mandible region into anterior (first premolars to second premolars) and posterior (first molars to second molars) segments. The average mesiodistal crown dimensions from each segment were measured as a midpoint. The reference point to measure the vertical bone height was established from the alveolar crest to the superior border of mandibular canal. Therefore, the measurement will begin at the midpoint of total mesiodistal crown dimension of each segment from the alveolar crest to the superior border of mandibular canal. All measurements were independently performed by two observers thrice on each modality. Results: A paired comparison between PAN and CBCT images in measuring the presurgical dental implant vertical height from alveolar crest to the superior border of mandibular canal (paired t-tests) showed statistically significant difference in the mean difference of vertical bone height at each region between PAN and CBCT (p<0.001). Conclusion: PAN radiograph provides sufficient information for presurgical implant assessment at the posterior mandible in routine cases or during the unavailability of CBCT at the clinic. However, CBCT remains the best imaging modality for presurgical implant assessment as it has a minimal magnification error.
Cost Analysis on Non-surgical and Surgical Therapy for the Management of Residual Pockets of Periodontitis Patients in Faculty of Dentistry Universiti Teknologi MARA: A Pilot Study
Authors: Salehuddin NQ , Md Sabri BA , Ariffin F
Published: January 2022

This study aims to quantify and analyze the cost distribution of periodontal intervention that includes non-surgical and surgical therapy in residual pockets management. Immediately after initial cause-related therapy (ICRT), subjects were allocated into two treatment groups: non-surgical (NS) or surgical (S) therapy. Clinical and cost data were recorded at baseline (Phase I) and periodontal review (Phase II). Direct and indirect cost distribution were estimated from patients' perspective and recorded in Ringgit Malaysia (RM) using activity-based costing methods. Indirect cost was calculated via productivity loss. The total average cost was RM1115.68 for the NS group and RM4558.28 for the S group. 46% and 66%of these were attributed to indirect cost while 54% and 34%to direct cost in NS and S groups respectively. Treatment charges and productivity lost attributed to the highest cost distribution in direct and indirect cost respectively. In conclusion, the cost of management of residual pockets in postgraduate periodontic clinic, Faculty of Dentistry UiTM was considered substantial and comparable to other non-communicable diseases and higher compared to management by government-based Periodontic Specialist clinics in Malaysia. These findings may assist in cost-reduction strategies and further justify the need for early detection and prevention of further disease progression.
Dental Anxiety and Phobia among Medical and Dental Undergraduates in Universiti Teknologi MARA (UiTM): A Cross-sectional Study
Authors: Baharuddin IH , Zainal M , Asmaon AF , Ghazali IA , Mohd Kama MS , Razlan AN
Published: January 2022

Objective: To assess the prevalence of dental anxiety and phobia among Malaysian medical and dental undergraduates of 2019. Materials and Methods: A validated Index of Dental Anxiety and Fear Scale (IDAF-4C+) questionnaires were distributed to medical and dental undergraduates in UiTM Sungai Buloh (n=460) via stratified random sampling. Demographic characteristics data were also collected. A cut point of 2.5 in average score for dental anxiety and fear (IDAF-4C) module was set to indicate the presence of dental anxiety. Descriptive statistics was used to determine the prevalence at while Pearson’s correlation was used to check its correlation towards related dental stimuli. The association of sociodemographic factors towards dental anxiety and fear were evaluated by logistic regression. Results: This study found that medical undergraduates reported higher prevalence of dental fear (25.6%) as compared to dental undergraduates (18.9%). The highest stimuli correlated to dental anxiety and fear is ‘feeling sick, queasy or disgusted’ (r=0.537) followed by ‘not being in control of what is happening’ (r=0.484).  Having unpleasant dental experience rose the likelihood of dental anxiety and fear by four times. Those from high-income family has 51.7% lower likelihood of dental anxiety and fear versus to those from low-income family. Conclusion: We conclude that dental anxiety is relatively prevalent even among medical and dental undergraduates in Malaysia. Feeling sick, queasy and disgusted are found to be the most correlated stimulus among medical undergraduates.