bluuebunny/crossref_metadata_2025 huggingface dataset:
A166: Evaluation of Quality Indicators and Disease Damage in Childhood‐Onset Systemic Lupus Erythematosus Patients
Authors: Harris Julia G. , Maletta Kristyn I. , Kuhn Evelyn M. , Olson Judyann C.
Published: March 2014

Background/Purpose:

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect virtually every organ system and may lead to significant morbidities. A recent publication identified quality indicators specific to childhood‐onset SLE (cSLE) based on scientific evidence and expert opinion. Our study measured compliance with certain quality indicators and assessed organ‐specific dysfunction in our cSLE population using a validated damage index, which will help define a baseline for which to optimize management and focus treatment to control the underlying disease and prevent adverse effects of therapy.

Methods:

A retrospective chart review was performed on patients diagnosed with SLE prior to age 18 who were followed in the Children's Hospital of Wisconsin Rheumatology Clinic for at least one year between January 1999 and August 2012. The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index was calculated to assess for chronic damage.

Results:

Analysis was performed on 75 patients with mean disease duration of 4.55 years. Eighty‐four percent of patients were female, 38.7% were black, 14.7% were Hispanic, and mean age of diagnosis was 13.2 years. The proportion of patients for whom care met the proposed quality indicators include: hydroxychloroquine use 94.6%, discussion of cardiovascular risk factors 17.3%, bone mineral density testing 26.7%, Vitamin D recommendation 81.3%, ophthalmologic examination 49.0%, influenza vaccination 70.3%, pneumococcal vaccination 25.3%, and meningococcal vaccination 47.2%. Disease damage was present in 41.3% of patients with average overall damage index score of 0.81. The most common entities leading to a damage score were cataracts, avascular necrosis, and diabetes. There was an association of disease damage at last follow‐up with minority race (p = 0.008) and with presence of vitamin D recommendation (p = 0.005). On the contrary, there was no statistical significance relating disease damage to lupus nephritis, age at diagnosis, body mass index, hydroxychloroquine use, or discussion of cardiovascular risk factors.

Conclusion:

Baseline application of proposed quality indicators in our cSLE population is varied ranging from 17.3% to 94.6%. This data is important to standardize care and target certain domains of disease management for improvement such as education and vaccination. The three most common areas of damage in our study may be related to corticosteroid use. This knowledge of organ‐specific damage is important to help identify at‐risk patients to optimize care and focus quality improvement efforts.
A172: Metaphyseal Chondrodysplasia, Ectodermal Dysplasia, Short Stature, Hypergammaglobulinemia, and Spontaneous Inflammation Without Infections in an Extended Family Due to Mutation in NFKB1A
Authors: Oberle Edward J. , Verbsky James W. , Routes John , Hintermeyer Mary , Worthey Elizabeth , Dasu Trivikram , Bengtson Christine , Buzzell Alyssa
Published: March 2014

Background/Purpose:

Autoinflammatory disorders are characterized by chronic inflammation and a variety of systemic complaints. Defects in the NF‐kB essential modifier pathway, or NEMO, are associated with an immune deficiency characterized by ectodermal dysplasia. We investigated an extended family with features of both chronic inflammation and NEMO following an autosomal dominant inheritance.

Methods:

Eight individuals from one family were evaluated. The proband, a male patient age 12 with known hypohydrosis, presented to our rheumatology clinic for chronic articular pain with bony hypertrophy of wrists, knees, and ankles. Plain radiographs and standard labs were obtained including ESR, CRP, CBC, and immunoglobulins for all affected individuals. Films were reviewed by two musculoskeletal radiologists. The proband underwent a proximal tibial bone biopsy, as well as genetic testing for known autoinflammatory disorders and mutations in NF‐kB pathway. The Tolllike Receptor (TLR) assay was used to evaluate NF‐kB function.

Results:

The proband, his father age 30, two brothers age 7 and 9, and his 2‐year‐old sister were all found to have ectodermal dysplasia, short stature and failure to thrive, chronic inflammation, elevated WBC, and hypergammaglobulinemia (Figure ). Radiographs of proband displayed sclerotic lesions of the metaphyses of distal radius/ulna, distal femora, and proximal and distal tibia/fibula (Figure ). The patient's father was evaluated as a child for bone issues, and radiographs demonstrate widened metaphyses of distal ulna and tibia. Bone biopsy of the proband was consistent with metaphyseal chondrodysplasia. Genetic testing for known autoinflammatory disorders was negative while testing of the NFKB1A gene demonstrated a heterozygous mutation (W11X). TLR responses were normal in two affected individuals indicating intact NF‐kB signaling. No infections were noted in the family.

Family pedigree.

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Proband radiographs.

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Conclusion:

This series demonstrates the clinical variability that can occur due to mutations in NFKB1A. Infections were not prevalent in this family, but spontaneous inflammation was common. In addition, this is the first report of metaphyseal chondrodysplasia as a complication of NEMO or related disorders.
A179: Improving Pneumococcal Vaccination Rate in the Pediatric Rheumatology Clinic
Authors: Harris Julia G. , Maletta Kristyn I. , Ren Bixiang , Olson Judyann C.
Published: March 2014

Background/Purpose:

This quality improvement project was conducted to increase pneumococcal vaccination rates in eligible Pediatric Rheumatology Clinic patients. Streptococcus pneumoniae is a leading cause of bacteremia, meningitis, pneumonia, sinusitis, and acute otitis media. Many patients in the Pediatric Rheumatology Clinic are at increased risk of pneumococcal disease secondary to a deficient immune system and/or immunosuppressive medications. Infections remain one of the leading causes of hospitalization and death in patients with certain rheumatic diseases. The Centers for Disease Control and Prevention recommends both the 13‐valent pneumococcal conjugate vaccine (PCV13) and the 23‐valent pneumococcal polysaccharide vaccine (PPSV23) for this high‐risk population.

Methods:

Baseline immunization rates were assessed for eligible clinic patients over a four week period. Eligible patients include children at least two years old and adults with systemic lupus erythematosus and patients currently on or starting an immunosuppressive medication. Interventions included a presentation to rheumatology providers and nurses, creation of clinic document with immunization algorithm, previsit planning, placing reminders on patient clinic forms, and sending letters to out‐of‐state patients. Chart reviews of eligible patients occurred throughout the study period. Control charts were established to portray change in immunization rate.

Results:

The pre‐intervention immunization rate for 90 eligible Pediatric Rheumatology Clinic patients was 6.7% for PCV13, 8.9% for PPSV23, and 0% for both vaccines. Data from 53 weeks were analyzed following the interventions for a total of 1123 eligible patient visits and 306 separate patients. The average post‐intervention immunization rate was 48.4% for PCV13, 28.4% for PPSV23, and 23.3% for both vaccines. These rates are statistically higher than the pre‐intervention rates (all p < 0.001). There was an increase in immunization rates following each major intervention.

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Conclusion:

Pneumococcal vaccination is an important part of the care for systemic lupus erythematosus patients and pediatric rheumatology patients on immunosuppressive medications. Simple interventions through this quality improvement project led to a marked increase in pneumococcal vaccination rates in this vulnerable population.
A181: Evaluating Decision‐Making in a Pediatric Rheumatology Clinic
Authors: David Jennie G. , Langer David A. , Kelso Gwendolyn , Lo Mindy S.
Published: March 2014

Background/Purpose:

Children with rheumatic disease often have chronic needs that require comprehensive, lifelong medical care. Transition of adolescent rheumatology patients from pediatric to adult institutions, in addition to a shift in legal responsibility, calls for the development and activation of medical decision‐making skills. Medical decision‐making is the umbrella term for the dynamic and evolving process of arriving at a medical decision, and is comprised of multiple factors including adherence, self‐management, patient activation, health consciousness, and patient empowerment. This study assessed adolescent and caregiver medical decision‐making characteristics in the outpatient Rheumatology clinic of a pediatric tertiary care hospital. We hypothesized that (1) pediatric patients who are more involved in their care have lower decisional conflict (i.e., conflict over making a medical decision), (2) adolescents want to be involved in their care, and (3) higher health consciousness is positively correlated with valuing involvement in medical decision‐making, actual involvement in decision making, and lower decisional conflict.

Methods:

This was an anonymous survey study of adolescent patients with chronic rheumatologic illness and their caregivers presenting to the outpatient Rheumatology clinic at Boston Children's Hospital. Both adolescent and caregiver surveys included measures pertaining to health consciousness, medical values, potential barriers to involvement in care, decisional conflict, perceived actual involvement, and desired involvement.

Results:

A total of twenty‐eight adolescent'caregiver pairs completed the survey. The mean age of adolescents was 16.14 years old (SD = 2.5). There was a significant positive correlation between adolescent and caregiver health consciousness (r = 0.43, p = 0.027). Valuing involvement in medical decision‐making by adolescent patients was positively correlated with their perception of actual involvement (r = 0.39, p = 0.04) and with their level of health consciousness (r = 0.48, p = 0.009). Furthermore, adolescent perception of actual involvement in medical decision‐making correlated negatively with their feelings of decisional conflict (r = −0.64, p <0.001).

Conclusion:

Adolescent patients with chronic rheumatic disease have considerable motivation for involvement in care. Given the link between treatment adherence and medical decision‐making, the characteristics of medical decision‐making in the pediatric rheumatology population are a valuable area for future research.
The ATLAS project: The effects of a constructionist digital laboratory project on undergraduate laboratory performance
Authors: Shoepe Todd C. , Cavedon Dana K. , Derian Joseph M. , Levy Celine S. , Morales Amy
Published: March 2014

Anatomical education is a dynamic field where developments in the implementation of constructive, situated‐learning show promise in improving student achievement. The purpose of this study was to examine the effectiveness of an individualized, technology heavy project in promoting student performance in a combined anatomy and physiology laboratory course. Mixed‐methods research was used to compare two cohorts of anatomy laboratories separated by the adoption of a new laboratory atlas project, which were defined as preceding (PRE) and following the adoption of the Anatomical Teaching and Learning Assessment Study (ATLAS; POST). The ATLAS project required the creation of a student‐generated, photographic atlas via acquisition of specimen images taken with tablet technology and digital microscope cameras throughout the semester. Images were transferred to laptops, digitally labeled and photo edited weekly, and compiled into a digital book using Internet publishing freeware for final project submission. An analysis of covariance confirmed that student final examination scores were improved (P < 0.05) following the implementation of the laboratory atlas project (PRE, n = 75; POST, n = 90; means ± SE; 74.9 ± 0.9 versus 78.1 ± 0.8, respectively) after controlling for cumulative student grade point average. Analysis of questionnaires collected (n = 68) from the post group suggested students identified with atlas objectives, appreciated the comprehensive value in final examination preparation, and the constructionism involved, but recommended alterations in assignment logistics and the format of the final version. Constructionist, comprehensive term‐projects utilizing student‐preferred technologies could be used to improve performance toward student learning outcomes. Anat Sci Educ 8: 12–20. © 2014 American Association of Anatomists.
The intermingled history of occupational therapy and anatomical education: A retrospective exploration
Authors: Carroll Melissa A. , Lawson Katherine
Published: March 2014

Few research articles have addressed the anatomical needs of entry‐level occupational therapy students. Given this paucity of empirical evidence, there is a lack of knowledge regarding anatomical education in occupational therapy. This article will primarily serve as a retrospective look at the inclusion of anatomical education in the occupational therapy curriculum. Focusing on the historical inclusion is the first step to address the gap in existing knowledge. Examining the history of anatomy in occupational therapy provides an educational context for curricular developments and helps current anatomical educators understand the evolution of occupational therapy as a profession. Exploring the educational history also offers anatomy educators an identity, as significant contributors, in the training and preparedness of entry‐level professionals while focusing on the ideals of occupational therapy. However, there is a critical need for empirical evidence of best teaching practices in occupational therapy and anatomical education. This manuscript provides a foundation and a starting point for further investigation into the anatomical competencies for entry‐level occupational therapists. Anat Sci Educ 7: 494–500. © 2014 American Association of Anatomists.
Susceptibility to Distraction in Autism Spectrum Disorder: Probing the Integrity of Oscillatory Alpha‐Band Suppression Mechanisms
Authors: Murphy Jeremy W. , Foxe John J. , Peters Joanna B. , Molholm Sophie
Published: March 2014

When attention is directed to one information stream over another, the brain can be configured in advance to selectively process the relevant stream and suppress potentially distracting inputs. One key mechanism of suppression is through the deployment of anticipatory alpha‐band (∼10 Hz) oscillatory activity, with greater alpha‐band power observed in cortical regions that will ultimately process the distracting stream. Atypical attention has been implicated in autism spectrum disorder (ASD), including greater interference by distracting task‐irrelevant inputs. Here we tested the integrity of these alpha‐band mechanisms in ASD using an intersensory attention task. Electroencephalography (EEG) was recorded while participants were cued on a trial‐by‐trial basis to selectively deploy attention to the visual or auditory modality in anticipation of a target within the cued modality. Whereas typically developing (TD) children showed the predicted alpha‐band modulation, with increased alpha‐band power over parieto‐occipital scalp when attention was deployed to the auditory compared with the visual modality, this differential pattern was entirely absent at the group level in the ASD cohort. Further, only the ASD group showed impaired performance due to the presence of task‐irrelevant sensory information. These data suggest that impaired modulation of alpha‐band activity plays a role in increased distraction from extraneous sensory inputs in ASD. Autism Res 2014, 7: 442–458. © 2014 International Society for Autism Research, Wiley Periodicals, Inc.
TGFβ signaling in cartilage development and maintenance
Authors: Wang Weiguang , Rigueur Diana , Lyons Karen M.
Published: March 2014

Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play essential roles in nearly every aspect of cartilage formation and maintenance. However, the mechanisms by which TGFβs transduce their effects in cartilage in vivo remain poorly understood. Mutations in several TGFβ family members, their receptors, extracellular modulators, and intracellular transducers have been described, and these usually impact the development of the cartilaginous skeleton. Furthermore, genome‐wide association studies have linked components of the (TGFβ) superfamily to susceptibility to osteoarthritis. This review focuses on recent discoveries from genetic studies in the mouse regarding the regulation of TGFβ signaling in developing growth plate and articular cartilage, as well as the different modes of crosstalk between canonical and noncanonical TGFβ signaling. These new insights into TGFβ signaling in cartilage may open new prospects for therapies that maintain healthy articular cartilage. Birth Defects Research (Part C) 102:37–51, 2014. © 2014 Wiley Periodicals, Inc.
Heterogeneous Catalysis of Multiple‐Electron‐Transfer Reactions at Nanoparticle‐Modified Electrodes
Authors: Laborda Eduardo , Neumann Christopher C. M. , Wang Ying , Ward Kristopher R. , Molina Ángela , Compton Richard G.
Published: March 2014

In some important electrochemical systems, the degree of electro‐reduction (or electro‐oxidation) of the reactant at the electrode surface depends on the extent of a surface‐catalysed reaction that involves intermediates formed by electron transfer. The catalytic properties of the electrode surface towards this heterogeneous reaction, therefore, can control the final product of important processes, such as the electro‐reduction of oxygen and some organic compounds. The modelling of the EChetEfd mechanism (where Chet is a heterogeneous chemical reaction and Efd indicates that the second electron transfer is fully driven) is considered in this paper at nanoparticle‐modified electrodes and homogeneous surface macroelectrodes. The influences of the chemical and electrochemical kinetics as well as the characteristics of the mass transport are investigated. The results enable us to propose procedures for the identification and characterisation of the surface‐catalysed process and for the optimisation of electrode modifications.
Mechanistic interpretation of artificial neural network‐based QSAR model for prediction of cathepsin K inhibition potency
Authors: Borišek Jure , Drgan Viktor , Minovski Nikola , Novič Marjana
Published: March 2014

Cathepsin K (Cat K) is a lysosomal cysteine protease that plays an important role in many bone diseases including osteoporosis, which makes Cat K an interesting drug target. Several compounds, including balicatib, were tested in clinical trials for their potency as Cat K inhibitors. Balicatib was found as a potent inhibitor; however, the side effects caused by the lysosomotropic drug candidate behavior as a consequence of its basic nature prevented further drug development. Here, we present a counter‐propagation artificial neural network (CP‐ANN) quantitative structure–activity relationship model of benzamide‐containing aminonitriles with good predictive ability. The quality of all models developed was evaluated internally by leave‐one‐out cross‐validation (LOOCV) on the training set and externally by an independent validation set. The best model performed with the LOOCV and external validation squared correlation coefficient of 0.81 and 0.84, respectively. In order to interpret the selection of variables and consequently discuss the mechanism of inhibition, the layer of the CP‐ANN model representing the distribution of individual molecular descriptors was compared with the output layer representing the response surface. The measures indicating the overlap/similarity of the response surface with selected levels in the input layer were introduced. The results signify not only the importance of the covalent bonding parameters, which are responsible for the S1 binding pocket of the enzyme, but also the impact of 3D shapes of the molecules on the inhibitor–enzyme interactions implying the stabilization of the inhibitors poses within the S2 and S3 binding sites. Copyright © 2014 John Wiley & Sons, Ltd.
Interaction between Anions and Cationic Metal Complexes Containing Tridentate Ligands with exo‐CH Groups: Complex Stability and Hydrogen Bonding
Authors: Martínez‐García Héctor , Morales Dolores , Pérez Julio , Puerto Marcos , del Río Ignacio
Published: March 2014

[Re(CO)3([9]aneS3)][BAr′4] (1), prepared by reaction of ReBr(CO)5, 1,4,7‐trithiacyclononane ([9]aneS3) and NaBAr′4, forms stable, soluble supramolecular adducts with chloride (2), bromide, methanosulfonate (3) and fluoride (4) anions. These new species were characterized by IR, NMR spectroscopy and, for 2 and 3, also by X‐ray diffraction. The results of the solid state structure determinations indicate the formation of CH⋅⋅⋅X hydrogen bonds between the anion (X) and the exo‐CH groups of the [9]aneS3 ligand, in accord with the relatively large shifts found by 1H NMR spectroscopy in dichloromethane solution for those hydrogens. The stability of the chloride adduct contrasts with the lability of the [9]aneS3 ligand in allyldicarbonyl molybdenum complexes recently studied by us. With fluoride, in dichloromethane solution, a second, minor neutral dimeric species 5 is formed in addition to 4. In 4, the deprotonation of a CH group of the [9]aneS3 ligand, accompanied by CS bond cleavage and dimerization, afforded 5, featuring bridging thiolates. Compounds [Mo(η3‐methallyl)(CO)2(TpyN)][BAr′4] (6) and [Mo(η3‐methallyl)(CO)2(TpyCH)][BAr′4] (7) were synthesized by the reactions of [MoCl(η3‐methallyl)(CO)2(NCMe)2], NaBAr′4 and tris(2‐pyridyl)amine (TpyN) or tris(2‐pyridyl)methane (TpyCH) respectively, and characterized by IR and 1H and 13C NMR spectroscopy in solution, and by X‐ray diffraction in the solid state. Compound 6 undergoes facile substitution of one of the 2‐pyridyl groups by chloride, bromide, and methanosulfonate anions. Stable supramolecular adducts were formed between 7 and chloride, bromide, iodide, nitrate, and perrhenate anions. The solid state structures of these adducts (12–16) were determined by X‐ray diffraction. Binding constants in dichloromethane were calculated from 1H NMR titration data for all the new supramolecular adducts. The signal of the bridgehead CH group is the one that undergoes a more pronounced downfield shift when tetrabutylammonium chloride was added to 7, whereas smaller shifts were found for the 2‐pyridyl C(3)H groups. In agreement, both types of CH groups form hydrogen bonds to the anions in the solid state structures.
Multidentate Europium Chelates as Luminoionophores for Anion Recognition: Impact of Ligand Design on Sensitivity and Selectivity, and Applicability to Enzymatic Assays
Authors: Schäferling Michael , Ääritalo Timo , Soukka Tero
Published: March 2014

The design of photoluminescent molecular probes for the selective recognition of anions is a major challenge for the development of optical chemical sensors. The reversible binding of anions to lanthanide centers is one promising option for the realization of anion sensors, because it leads in some cases to a strong luminescence increase by the replacement of quenching water molecules. Yet, it is an open problem to gain control of the sensitivity and selectivity of the luminescence response. Primarily, the selective detection of (poly)phosphate species such as nucleotides has emerged as a demanding task, because they are involved in many biological processes and enzymatic reactions. We designed a series of pyridyl‐based multidentate europium complexes (seven‐, six‐, and five‐dentate) including sensitizing chromophores and studied their luminescence intensity and lifetime responses to different (poly)phosphates (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), cyclic adenosine monophosphate (cAMP), pyrophosphate, and phosphate anions), and carboxyanions (citrate, malate, oxalacetate, succinate, α‐ketoglutarate, pyruvate, oxalate, carbonate). The results reveal that the number of free coordination sites has a significant impact on the sensitivity and selectivity of the response. Because of its reversibility, the lanthanide probes can be applied to monitor the activity of ATP‐consuming enzymes such ATPases and apyrases, which is demonstrated by means of the five‐dentate complex.
Amidines for Versatile Ruthenium(II)‐Catalyzed Oxidative CH Activations with Internal Alkynes and Acrylates
Authors: Li Jie , John Michael , Ackermann Lutz
Published: March 2014

Cationic ruthenium complexes derived from KPF6 or AgOAc enabled efficient oxidative CH functionalizations on aryl and heteroaryl amidines. Thus, oxidative annulations of diversely decorated internal alkynes provided expedient access to 1‐aminoisoquinolines, while catalyzed CH activations with substituted acrylates gave rise to structurally novel 1‐iminoisoindolines. The powerful ruthenium(II) catalysts displayed a remarkably high site‐, regio‐ and, chemoselectivity. Therefore, the catalytic system proved tolerant of a variety of important electrophilic functional groups. Detailed mechanistic studies provided strong support for the cationic ruthenium(II) catalysts to operate by a facile, reversible CH activation.
ChemInform Abstract: Structural, Vibrational and Electrical Properties of Ordered Double Perovskite Oxide BaLaMnSbO6.
Authors: Bharti Chandrahas , Sen A. , Chanda Sadhan , Sinha T. P.
Published: March 2014

BaLaMnSbO6 is successfully synthesized by calcination of stoichiometric amounts of BaCO3, La2O3, MnO, and Sb2O5 (alumina crucible; 1.
ChemInform Abstract: Preparation and Luminescence Characteristics of Eu‐Doped Calcium Chloride Silicate Ca7Si2O8Cl6.
Authors: Wang Jing , Zhang Wanqi , Qi Shuyun , Guan Ying , Lu Juan
Published: March 2014

Eu‐activated Ca7Si2O8Cl6 phosphors are prepared by calcination of a stoichiometric mixture of CaCO3 and SiO2 in the presence of 0.1—5.0 mol% Eu2O3 (air, 850 °C, 5—10 h) before fluxing the resulting powder with CaCl2 (N2/5%H2 atmosphere, corundum boat, 1100 °C, 5—10 h).
ChemInform Abstract: Magnetic Properties of Tl9LnTe6, Ln: Ce, Pr, Tb and Sm.
Authors: Bangarigadu‐Sanasy Savitree , Sankar Cheriyedath Raj , Dube Paul A. , Greedan John E. , Kleinke Holger
Published: March 2014

The title compounds are prepared by reaction of stoichiometric mixtures of the elements (evacuated silica tube, 1.
ChemInform Abstract: Magnetic, Thermal and Electronic Properties of Ce11Ni4In9 and CeNi9In2.
Authors: Szytula A. , Baran S. , Penc B. , Przewoznik J. , Winiarski A. , Tyvanchuk Yu. , Kalychak Ya. M.
Published: March 2014

Polycrystalline samples of Ce11Ni4In9 (I) and CeNi9In2 (II) are prepared by arc melting of the elements followed by annealing at 670 K for (I) and 870 K for (II).
ChemInform Abstract: A Reversible and Stable Flake‐Like LiCoO2 Cathode for Lithium Ion Batteries.
Authors: Wei Tao , Zeng Rui , Sun Yongming , Huang Yunhui , Huang Kevin
Published: March 2014

A micro‐sized LiCoO2 cathode for lithium ion batteries with thick and dense flake morphology is synthesized from a mixture of CoO nanodisks (obtained from an aqueous solution of Co(OAc)2 and N2H4, followed by annealing at 300 °C for 2 h) and LiOH·H2O in EtOH solution (850 °C, 10 h).
ChemInform Abstract: Facile Synthesis of Nanostructured CuCo2O4 as a Novel Electrode Material for High‐Rate Supercapacitors.
Authors: Pendashteh Afshin , Rahmanifar Mohammad S. , Kaner Richard B. , Mousavi Mir F.
Published: March 2014

CuCo2O4 particles in the shape of cauliflower‐like structures are prepared by sonication of an aqueous solution of Cu(NO3)2 and Co(NO3)2 at 50 °C for 1 h, followed by addition of urea and evaporation of water at 80 °C for 12 h.
ChemInform Abstract: Synthesis and Characterization of a New Organically Templated Open‐Framework Beryllium Phosphite with 3, 4‐Connected Networks.
Authors: Wang Guo‐Ming , Zhang Xiao , Li Jin‐Hua , Wang Pei , Wang Zong‐Hua , Wang Ying‐Xia , Lin Jian‐Hua
Published: March 2014

The new open‐framework compound (Hdien)2[Be3(HPO3)4] (dien: diethylenetriamine) is hydrothermally synthesized from a mixture of BeSO4, H3PO3, dien, ethylene glycol, and H2O (autoclave, 170 °C, 7 d, 84% yield).
ChemInform Abstract: Formation, Self‐Assembly and Transformation of a Transient Selenotungstate Building Block into Clusters, Chains and Macrocycles.
Authors: Cameron Jamie M. , Gao Jing , Vila‐Nadal Laia , Long De‐Liang , Cronin Leroy
Published: March 2014

Five new selenotungstates are synthesized based on the formation and subsequent assembly of the previously unreported [Se2W12O46]12‐ building block.
ChemInform Abstract: Crystal Structure of Yb2CuGe6 and Yb3Cu4Ge4 and the Valency of Ytterbium.
Authors: Peter Sebastian C. , Subbarao Udumula , Sarkar Sumanta , Vaitheeswaran G. , Svane Axel , Kanatzidis Mercouri G.
Published: March 2014

Single crystals of Yb2CuGe6 (I) and Yb3Cu4Ge4 (II) are prepared by melting of the elements in a Y/Cu/Ge molar ratio of 3:2:6 and 3:3:6, resp., in an indium flux (alumina crucible in evacuated silica tube, 850 °C, 2 d, slow cooling).
ChemInform Abstract: Synthesis and Characterization of a Novel Quaternary Chalcogenide KBiCu2S3.
Authors: Zhang Ganghua , Zhang Bowen , Chen Haijie , Zhang Xian , Zheng Chong , Lin Jianhua , Huang Fuqiang
Published: March 2014

KBiCu2S3 is prepared via a facile hydrothermal approach comprising aqueous solutions of KOH, Cu(OAc)2, Bi(NO3)3, and sulfur (autoclave, 240 °C 2—7 d).
ChemInform Abstract: Pd5InSe and Pd8In2Se — New Metal‐Rich Homological Selenides with 2D Palladium—Indium Fragments: Synthesis, Structure and Bonding.
Authors: Zakharova Elena Yu. , Kazakov Sergey M. , Isaeva Anna A. , Abakumov Artem M. , Tendeloo Gustaaf Van , Kuznetsov Alexey N.
Published: March 2014

Pd5InSe (I) and Pd8In2Se (II) are prepared by repeated vacuum annealing, interim homogenization, and pelletizing (silica tube, 550—750 °C, 10—24 d).
ChemInform Abstract: Phosphine‐Catalyzed Domino Reaction: An Efficient Method for the Synthesis of Bicyclo[3.2.0]heptenes Skeleton.
Authors: Zheng Jie , Huang You , Li Zhengming
Published: March 2014

Dienic sulfones and γ‐methyl allenoates can be converted into bicyclo[3.2.0]heptene derivatives using trimethylphosphine as the catalyst under mild conditions.
ChemInform Abstract: 2‐Iodoxybenzoic Acid Organosulfonates: Preparation, X‐Ray Structure and Reactivity of New, Powerful Hypervalent Iodine(V) Oxidants.
Authors: Yusubov Mekhman S. , Svitich Dmitrii Yu. , Yoshimura Akira , Nemykin Victor N. , Zhdankin Viktor V.
Published: March 2014

New hypervalent iodine(V) oxidants are prepared by the reaction of IBX with sulfonic acids.
ChemInform Abstract: Enantioselective Biooxidation of Racemic trans‐Cyclic Vicinal Diols: One‐Pot Synthesis of Both Enantiopure (S,S)‐Cyclic Vicinal Diols and (R)‐α‐Hydroxy Ketones.
Authors: Zhang Jiandong , Xu Tingting , Li Zhi
Published: March 2014

Recombinant Escherichia coli expressing BDHA or both BDHA and LDH are engineered as efficient whole‐cell biocatalysts.
ChemInform Abstract: Transformations of Peroxide Olefin Ozonolysis Products under the Action of Hydroxylamine and Semicarbazide Hydrochlorides in Isopropyl Alcohol.
Authors: Ishmuratov G. Yu. , Legostaeva Yu. V. , Garifullina L. R. , Botsman L. P. , Idrisova Z. I. , Muslukhov R. R. , Ishmuratova N. M. , Tolstikov G. A.
Published: March 2014

Hydroxylamine and semicarbazide hydrochlorides are found to be effective reducing agents towards peroxide products of ozonolysis of olefins with different degrees of substitution.
ChemInform Abstract: Practical Metal‐ and Additive‐Free Methods for Radical‐Mediated Reduction and Cyclization Reactions.
Authors: Jiang Hao , Bak Jesper R. , Lopez‐Delgado Francisco Javier , Joergensen Karl Anker
Published: March 2014

The radical reduction of a variety of substrates, e.g. halogenides (V) and (VII), is achieved using (Tms)3SiH as hydride source and air or light as radical initiator.
ChemInform Abstract: Efficient Cross‐Coupling of Aryl Grignard Reagents with Alkyl Halides by Recyclable Ionic Iron(III) Complexes Bearing a Bis(phenol)‐functionalized Benzimidazolium Cation.
Authors: Xia Chong‐Liang , Xie Cun‐Fei , Wu Yu‐Feng , Sun Hong‐Mei , Shen Qi , Zhang Yong
Published: March 2014

Ionic Fe(III)‐complexes based on novel bis(phenol)‐functionalized benzimidazolium cation are synthesized and applied to the cross‐coupling of Grignard reagents (I) with primary and secondary alkyl halides (II) bearing β‐hydrogens.
ChemInform Abstract: An Unusual Involvement of NaIO4 in the Acetylation of Bisphenol During Attempted Oxidative Acetylation.
Authors: Singh Deepak , Deota Pradeep T.
Published: March 2014

Treatment of bisphenols with NaIO4 in acetic anhydride provides unexpected acetylated products instead of bis‐acetoxy cyclohexadienone derivatives.
ChemInform Abstract: Stereoretentive Copper(II)‐Catalyzed Ritter Reactions of Secondary Cycloalkanols.
Authors: Al‐huniti Mohammed H. , Lepore Salvatore D.
Published: March 2014

The title reaction of cyclic alcohols with aryl and alkyl nitriles results in the formation of amides under mild conditions.
ChemInform Abstract: One‐Pot Multi‐Component Synthesis and Solid State Structures of Functionally Rich Polyether Macrocycles.
Authors: Vishe Mahesh , Hrdina Radim , Guenee Laure , Besnard Celine , Lacour Jerome
Published: March 2014

Rhodium‐catalyzed decomposition of methyl diazoacetoacetate in the presence of substituted cyclic ethers results in the formation of novel functionalized macrocycles.
ChemInform Abstract: Silicon Acceleration of a Tandem Alkene Isomerization/Electrocyclic Ring‐Opening of 2‐Methyleneoxetanes to α,β‐Unsaturated Methylketones.
Authors: Farber Elisa , Rudnitskaya Aleksandra , Keshipeddy Santosh , Lao Kendricks S. , Gascon Jose A. , Howell Amy R.
Published: March 2014

Heating of methyleneoxetanes is found to result in new, unexpected, and selective formation of methyl vinylketones via oxetene intermediates.
ChemInform Abstract: Direct Synthesis of β‐Hydroxy‐α‐amino Acids via Diastereoselective Decarboxylative Aldol Reaction.
Authors: Singjunla Yuttapong , Baudoux Jerome , Rouden Jacques
Published: March 2014

A straightforward metal‐free synthesis of anti‐β‐hydroxy‐α‐amino acids is described.
ChemInform Abstract: Rhenium‐Catalyzed Oxidative Cyanation of Tertiary Amines with TMSCN.
Authors: Lin Aijun , Peng Hao , Abdukader Ablimit , Zhu Chengjian
Published: March 2014

This describes novel high‐valent rhenium complexes which are used for the title reaction for the first time yielding α‐cyanated amines.
ChemInform Abstract: An Efficient and Convenient Synthesis of Unsymmetrical Disulfides from Thioacetates.
Authors: Lach Slawomir , Demkowicz Sebastian , Witt Dariusz
Published: March 2014

Reaction of phosphorinanyl‐disulfanyl derivatives (I) with thioacetates (II) in the presence of NaOMe or BuNH2 as the base offers a convenient method for the synthesis of unsymmetrical disulfides.
ChemInform Abstract: Highly Substituted Enantioenriched Cyclopentane Derivatives by Palladium‐Catalyzed [3 + 2] Trimethylenemethane Cycloadditions with Disubstituted Nitroalkenes.
Authors: Trost Barry M. , Bringley Dustin A. , O'Keefe B. Michael
Published: March 2014

β‐Disubstituted nitroalkenes readily undergo palladium‐catalyzed [3 + 2] cycloaddition with trimethylenemethane to generate nitrocyclopentanes in excellent yield and enantioselectivity.
ChemInform Abstract: Concerted Two‐Electron Transfer and High Selectivity of TiO2 in Photocatalyzed Deoxygenation of Epoxides.
Authors: Li Yue , Ji Hongwei , Chen Chuncheng , Ma Wanhong , Zhao Jincai
Published: March 2014

It is shown, that the concerted multi‐electron transfer is the dominant pathway in the photocatalytic deoxygenation of epoxides on a pristine TiO2 surface to give the corresponding alkenes.
ChemInform Abstract: Trifluoromethylation of Aryl and Heteroaryl Halides with Fluoroform‐Derived CuCF3: Scope, Limitations, and Mechanistic Features.
Authors: Lishchynskyi Anton , Novikov Maxim A. , Martin Eddy , Escudero‐Adan Eduardo C. , Novak Petr , Gushin Vladimir V.
Published: March 2014

In the presence of fluoroform‐derived CuCF3 a wide range of aromatic iodides and bromides are found to undergo trifluoromethylation with high chemoselectivity and efficiency.
ChemInform Abstract: α‐Arylation, α‐Arylative Esterification, or Acylation: A Stoichiometry‐Dependent Trichotomy in the Pd‐Catalyzed Cross‐Coupling Between Aldehydes and Aryl Bromides.
Authors: Nareddy Pradeep , Mazet Clement
Published: March 2014

α‐Branched aldehydes react with aryl bromides and 1 equiv.
ChemInform Abstract: New Chiral Iodooxazoline Catalysts for the I(III)‐Mediated α‐Tosyloxylation of Ketones: Refining the Stereoinduction Model.
Authors: Therien Marie‐Eve , Guilbault Audrey‐Anne , Legault Claude Y.
Published: March 2014

The catalyst with the best performance is shown.
ChemInform Abstract: Carbonylative Sonogashira Coupling in the Synthesis of Ynones: A Study of “Boomerang” Phenomena.
Authors: Genelot Marie , Dufaud Veronique , Djakovitch Laurent
Published: March 2014

The carbonylative Sonogashira reaction of o‐iodoanilines, carbon monoxide, and arylalkynes is extensively studied using Pd(II)‐complexes grafted on silica such as SBA‐15 as catalyst.
ChemInform Abstract: Direct Amidation from Alcohols and Amines through a Tandem Oxidation Process Catalyzed by Heterogeneous‐Polymer‐Incarcerated Gold Nanoparticles under Aerobic Conditions.
Authors: Soule Jean‐Francois , Miyamura Hiroyuki , Kobayashi Shu
Published: March 2014

The reaction of the benzylic, olefinic and propargyl alcohols with primary amines is effective under oxygen atmosphere using carbon‐black‐stabilized polymer‐incarcerated Au/Co nanoparticles.
ChemInform Abstract: Construction of an Asymmetric Quaternary Carbon Center via Allylation of Hydrazones.
Authors: Kim Jin Bum , Satyender Apuri , Jang Doo Ok
Published: March 2014

The allylation of chiral Z‐ and E‐hydrazones of type (I) and (V), resp., is studied.
ChemInform Abstract: Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross‐Benzoin Reaction of α‐Diketones with Aldehydes.
Authors: Bortolini Olga , Fantin Giancarlo , Ferretti Valeria , Fogagnolo Marco , Giovannini Pier Paolo , Massi Alessandro , Pacifico Salvatore , Ragno Daniele
Published: March 2014

Deprotonation of DMSO with catalytic amounts of KOtBu generates methylsulfinyl carbanions in situ.
ChemInform Abstract: Copper(II)‐Catalyzed Reactions of Dimethylformamide with Phenylacetonitrile and Sulfur to Form N,N‐Dimethylthioamides.
Authors: Qu Yanyang , Li Zhengkai , Xiang Haifeng , Zhou Xiangge
Published: March 2014

The selective preparation of phenylethanethioamides and thiobenzamides is achieved via copper‐catalyzed reaction of phenylacetonitriles, DMF and sulfur.
ChemInform Abstract: Copper‐Catalyzed One‐Pot Synthesis of N‐Sulfonylalkanimidoyl Thiocyanates from Sulfonyl Azides, Alkynes, and KSCN.
Authors: Yavari Issa , Damghani Tahereh , Nematpour Manijeh
Published: March 2014

Ketenimine intermediates, generated by the addition of copper acetylide to sulfonyl azides (II), are trapped by KSCN (III) to afford target compounds (IV) in moderate to good yields.
ChemInform Abstract: Synthesis, Characterization and Catalytic Activity of Palladium Complexes with α‐Imino—Amidos Ligands.
Authors: Cao Gao , Yang Hai‐Qing , Luo Bao‐Tian , Liu Feng‐Shou
Published: March 2014

Iminoamines are found to be efficient ligands for the Pd‐catalyzed Suzuki—Miyaura coupling of aryl bromides and chlorides with aryl boronic acids.
ChemInform Abstract: Efficient Click‐Polymer‐Stabilized Palladium Nanoparticle Catalysts for Suzuki—Miyaura Reactions of Bromoarenes and Reduction of 4‐Nitrophenol in Aqueous Solvents.
Authors: Deraedt Christophe , Salmon Lionel , Ruiz Jaime , Astruc Didier
Published: March 2014

Palladium nanoparticles (size=1.6.+‐.0.3 nm) used for the Suzuki—Miyaura coupling of aryl bromides with phenyl boronic acid are stabilized by polyethylene glycol containing triazolyl rings synthesized by click reaction in water.
ChemInform Abstract: Synthesis of α‐Di or Trisubstituted (Tetrahydrofuran‐2‐yl)methanols via Photoinduced Additive‐Free Intermolecular Addition of THF to Aromatic Aldehydes or Ketones.
Authors: Hao Xinqi , Liu Chaoli , Liu Chenli , Chen Yiyong , Zhao Xuemei , Song Maoping , Qian Rong , Guo Hao
Published: March 2014

The title synthesis provides the target products in only moderate yields.
ChemInform Abstract: A Bioinspired Route to Indanes and Cyclopentannulated Hetarenes via (3 + 2)‐Cyclodimerization of Donor—Acceptor Cyclopropanes.
Authors: Ivanova Olga A. , Budynina Ekaterina M. , Skvortsov Dmitriy A. , Limoge Michelle , Bakin Andrei V. , Chagarovskiy Alexey O. , Trushkov Igor V. , Melnikov Mikhail Ya.
Published: March 2014

The Lewis‐acid catalyzed reaction gives the title compounds stereoselectively in short time and high yields.
ChemInform Abstract: Effects of Solvent and Temperature on the Reaction of 1,2,3,4‐Tetrafluoroanthraquinone with 4‐tert‐Butylbenzenethiol.
Authors: Loskutov V. A.
Published: March 2014

Depending on solvent and temperature, the title reaction leads to mixtures of five different substitution products.
ChemInform Abstract: Iron(III) Chloride Catalyzed Synthesis of Functionalized Spiropyrimidines.
Authors: Majumdar K. C. , Ponra Sudipta , Ghosh Tapas
Published: March 2014

The reaction requires an aromatic substituent at the alkyne moiety and N‐substitution in the pyrimidine ring.
ChemInform Abstract: Stereoselective Synthesis of Fluoroalkylated Butanolides.
Authors: Erdbrink Holger , Czekelius Constantin
Published: March 2014

Optically active fluoroalkylated acyl oxazolidines are converted into di‐ and trisubstituted butanolides with high diastereoselectivity.
ChemInform Abstract: Electrophilic Addition of Allylic Carbocations to 2‐Cyclopropylidene‐2‐arylethanols: A Strategy to 3‐Oxabicyclo[3.2.0]heptanes.
Authors: Meng Bo , Huang Xian , Wu Luling
Published: March 2014

The construction of 3‐oxabicyclo[3.2.0]heptanes is developed using the electrophilic addition of carbocations generated from functionalized allylic alcohols to cyclopropylidene substituted ethanols (I).
ChemInform Abstract: Platinum‐Catalyzed Divergent Reactivity of α‐Hydroxyallenes: Synthesis of Dihydrofurans and α,β‐Unsaturated Ketones.
Authors: Alcaide Benito , Almendros Pedro , Fernandez Israel , Martinez del Campo Teresa , Naranjo Teresa
Published: March 2014

The reaction of α‐allenols (I) in the presence of PtCl2 as a catalyst results in intramolecular cyclization to dihydrofurans (II) whereas a binary Pt/Ag‐catalyst promotes rearrangement to E/Z‐mixtures of α,β‐unsaturated ketones.
ChemInform Abstract: Synthetic Routes Toward Asymmetrically Substituted (Functionalized) 4H‐Cyclopenta[2,1‐b:3,4‐b′]dithiophenes.
Authors: Vanormelingen Wouter , Verstappen Pieter , Maes Veronique , Bevk David , Lutsen Laurence , Vanderzande Dirk , Maes Wouter
Published: March 2014

A convenient two‐step sequence is presented for the conversion of ketone (I) into asymmetrically dialkylated derivatives via Wittig‐type olefination followed by regioselective alkylation of the exocyclic double bond.
ChemInform Abstract: Chiral Primary‐Amine‐Catalyzed Conjugate Addition to α‐Substituted Vinyl Ketones/Aldehydes: Divergent Stereocontrol Modes on Enamine Protonation.
Authors: Fu Niankai , Zhang Long , Luo Sanzhong , Cheng Jin‐Pei
Published: March 2014

The reactions of α‐substituted vinyl aldehydes are a summary of previous results and are not shown.
ChemInform Abstract: Metal Free Sulfenylation and Bis‐sulfenylation of Indoles: Persulfate Mediated Synthesis.
Authors: Prasad Ch. Durga , Kumar Shailesh , Sattar Moh. , Adhikary Amit , Kumar Sangit
Published: March 2014

A metal and halogen free, simple method for the selective sulfenylation of indoles (I) with diaryl disulfides (II) is reported.
ChemInform Abstract: Enantioselective Friedel—Crafts Alkylation for Synthesis of 2‐Substituted Indole Derivatives.
Authors: Zhang Yulong , Liu Xiaohua , Zhao Xiaohu , Zhang Jianlin , Zhou Lin , Lin Lili , Feng Xiaoming
Published: March 2014

The catalytic asymmetric intermolecular C2 Friedel—Crafts alkylation of N‐methyl skatole (I) with β,γ‐unsaturated α‐ketoesters (II) is realized by a chiral Ni(II)‐complex.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Annulation via C—H/N—H Functionalization: Access to Substituted Pyrroles.
Authors: Peng Shiyong , Wang Lei , Huang Jiayao , Sun Shaofa , Guo Haibing , Wang Jian
Published: March 2014

An efficient synthesis of highly substituted pyrroles is developed using a Pd‐catalyzed oxidative reaction of 4‐aminocoumarins with internal alkynes.
ChemInform Abstract: Bi(OTf)3 — A Mild Catalyst for the Synthesis of Difficult to Obtain C‐Alkyl Substituted Glycolurils.
Authors: Wu Feng , Mandadapu Vijaybabu , Day Anthony I.
Published: March 2014

Glycolurils [(III), (V), and (VIII)] are synthesized using Bi(OTf)3 instead of traditional acid catalysts.
ChemInform Abstract: Isoxazole Derivatives as Potent Transient Receptor Potential Melastatin Type 8 (TRPM8) Agonistis.
Authors: Ostacolo Carmine , et al. et al.
Published: March 2014

Twelve new isoxazole derivatives are synthesized and evaluated for their pharmacological properties both in F11 sensory neurons in vitro and in an in vivo model of cold allodynia.
ChemInform Abstract: Novel Acetamidothiazole Derivatives: Synthesis and in vitro Anticancer Evaluation.
Authors: Ali Ahmed R. , El‐Bendary Eman R. , Ghaly Mariam A. , Shehata Ihsan A.
Published: March 2014

The synthesis of a new series of acetamidothiazole derivatives is given.
ChemInform Abstract: Regioselective Synthesis of 1,2,3‐Triazolyl Derivatives of Calix[4]arenes Based on 1,3‐Dipolar Cycloaddition.
Authors: Burilov V. A. , Epifanova N. A. , Popova E. V. , Vasilevsky S. F. , Solovieva S. E. , Antipin I. S. , Konovalov A. I.
Published: March 2014

The title reaction is catalyzed by copper iodide.
ChemInform Abstract: The Reaction of N‐Isocyaniminotriphenylphosphorane with 2‐Oxopropylbenzoate (or 4‐Bromobenzoate) and a Primary Amine in the Presence of (E)‐Cinnamic Acid Derivatives: A One‐Pot Efficient Four‐Component Reaction of the Synthesis of 2‐(Arylamino)‐2‐(5‐aryl‐1‐ethenyl‐1,3,4‐oxadiazol‐2‐yl) Propyl Benzoate (or 4‐Bromobenzoate) Derivatives.
Authors: Ramazani Ali , Ahmadi Yavar , Nasrabadi Fatemeh Zeinali , Rouhani Morteza
Published: March 2014

A mild, simple and efficient methodology for the preparation of sterically congested title oxadiazole compounds (V) (12 examples) is reported.
ChemInform Abstract: Controllable Direct Arylation: Fast Route to Symmetrical and Unsymmetrical 4,7‐Diaryl‐5,6‐difluoro‐2,1,3‐benzothiadiazole Derivatives for Organic Optoelectronic Materials.
Authors: Zhang Junxiang , Chen Wayne , Rojas Anthony J. , Jucov Evgheni V. , Timofeeva Tatiana V. , Parker Timothy C. , Barlow Stephen , Marder Seth R.
Published: March 2014

An efficient protocol for the double symmetrical arylation using aryl bromides, one‐pot or sequential arylation using two different aryl bromides or monoarylation of difluorobenzothiadiazole is developed.
ChemInform Abstract: 1,6‐Conjugate Addition of Carbon Nucleophiles to (E)‐2‐Styrylchromones: Unexpected Synthesis of a Stereochemically Complex Pentasubstituted Spirocyclohexane.
Authors: Silva Eduarda M. P. , Grenda Kinga , Cardoso Ines N. , Silva Artur M. S.
Published: March 2014

The addition of ethyl malonate and malononitrile to styrylchromones proceeds with high regioselectivity to produce target products in low to moderate yields.
ChemInform Abstract: Reactivity of Sarcosine and 1,3‐Thiazolidine‐4‐carboxylic Acid Towards Salicylaldehyde‐Derived Alkynes and Allenes.
Authors: Ribeiro Laia Fernanda M. , Gomes Clara S. B. , Pinho e Melo Teresa M. V. D.
Published: March 2014

The reactivity of sarcosine (II) and 1,3‐thiazolidine‐4‐carboxylic acid (XI) towards salicylaldehyde‐derived alkynes [(I) and (V)] and allenes [(VII) and (IX)] is explored as a strategy to obtain new chromeno[4,3‐b]pyrrole derivatives.