bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Term Complete Response of Advanced Lung Squamous Cell Carcinoma in an Elderly Patient Treated with First-Line Anti-PD-1 Antibody Monotherapy: A Case Report
Authors: Pan Xue , Xing Yufei , Yang Wenhong , Shi Minhua
Published: March 2022

ABSTRACT

Introduction and importance:

Lung cancer is extremely difficult to treat due to its high incidence and mortality rate. Immune checkpoint inhibitor therapy is a major breakthrough in the field of oncology and is an emerging anti-tumor treatment modality after chemotherapy, targeted therapy and anti-angiogenic therapy. However, patients with complete response were also noticed as an anecdote especially in the aged. Here we presented a non-small cell lung cancer case who benefited from treatment of anti-PD-1 antibody.

Case presentation:

An 80-year-old male was admitted, presenting with a intermittent cough and a small amount of blood in the sputum for 2 months, computed tomography showed a lesion in the right lung. Lung puncture biopsy results suggested lung squamous cell carcinoma. Wild-type epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) were showed in the tumor tissue specimen. Anti-programmed death 1 (PD-1) antibody monotherapy was initiated for 13 cycles. After the first anti-PD-1 antibody treatment, cryotherapy was performed under tracheoscopy on the mucosal bulge of the right principal bronchus and the root of the right upper lobe bronchial neoplasm. Complete remission (CR) was confirmed via imaging before the 3rd cycle. Subsequent CT suggested stable disease conditions. The presence of CR was further confirmed through a Positron Emission Computed Tomography (PET)/CT test in the 13th cycle. The patient now experienced a long-term complete response of more than 4 years till now.

Clinical Discussion:

Lung cancer has the highest morbidity and mortality in China. Immune monotherapy has become the standard first-line treatment for patients with upregulated expression of programmed death-ligand 1 (PD-L1). The effect of immunotherapy is similar and equally safe in older and younger patients with lung cancer. Monotherapy has the potential to achieve rapid lesion regression in elderly lung cancer patients, and the presence of immunological memory in T lymphocytes may be responsible for long-term response of the tumor lesions.

Conclusion:

We reported a long-term complete response of advanced lung squamous cell carcinoma in aged treated with first-line anti-PD-1 antibody monotherapy. More studies are needed to evaluate the efficacy and safety of immune checkpoint inhibitors in the aged.

Highlights:
Los ‘90 y la preocupación por lo público en el ámbito universitario regional
Authors: Saint Paul Mariana
Published: March 2022

El artículo analiza los discursos político-pedagógicos regionales de mediados de los años 90, en discusión con las políticas nacionales universitarias. Interroga en estos, las formas en que las/ los “intelectuales” locales responden al conjunto de medidas que el menemismo adoptó para la universidad pública argentina y que regularon las formas de producción y circulación del conocimiento. En el estudio se aborda la centralidad de estos discursos, respecto a los denominados “grandes centros urbanos” en los que se produce conocimiento legítimo y válido, asumiendo una definición amplificada de “intelectuales”. Finalmente, se delimitan dos ejes temporales: de 1983 a 1990 y de 1993 a 1996, bajo el presupuesto de que existe una tensión en torno de la recepción de las políticas de los años 90, que osciló entre las luchas y el rechazo a las mismas y la necesidad de consolidar y legitimar el ámbito académico de la Facultad de Ciencias de la Educación.
Authors: Rohmawati Lia , Nugroho Arya Setya
Published: March 2022

Penelitian ini bertujuan untuk mengetahui keefektifan media diorama berbasis kearifan lokal pada subtema keunikan daerah tempat tinggalku kelas IV SDN Pandanan. Adapun Subjek penelitian ini di SD Negeri Pandanan dengan 16 orang peserta didik yang terdiri dari 13 laki-laki dan 3 perempuan. Metode pengumpulan data yang digunakan yaitu metode observasi, dan metode tes. Sedangkan instrumen penelitian menggunakan lembar observasi aktivitas guru, lembar observasi aktivitas peserta didik dan lembar tes hasil belajar guna mengetahui hasil belajar peserta didik. Hasil dari kemampuan guru dalam mengelola pembelajaran mencapai kriteria sangat baik, karena dalam keseluruhan pertemuan memiliki rata – rata 93,7 yang berada diantara skala 85 - 100 yang termasuk dalam kategori sangat baik. Aktivitas peserta didik termasuk dalam kategori aktif yaitu mencapai 63,35% Dari prosentase yang harus dicapai ≥ 50%. Tes hasil belajar mencapai 87,5% dan dikatakan tuntas apabila ketuntasan klasikal minimal mencapai ≥75%. Maka dapat disimpulkan bahwa media diorama dapat digunakan sebagai media penunjang pembelajaran.
Dukungan petugas kesehatan memengaruhi pemeriksaan pap smear pada wanita usia subur
Authors: Wuriningsih Apriliani Yulianti , Nafisa Diah Ummul , Wahyuni Sri , Rahayu Tutik , Distinarista Hernandia
Published: March 2022

Pendahuluan: Kanker serviks adalah penyakit yang memengaruhi kesehatan organ reproduksi wanita. Angka kematian akibat kanker serviks terus meningkat, terutama disebabkan karena keterlambatan pengobatan dan kurangnya kesadaran untuk melakukan deteksi dini. Tingginya angka kejadian penderita kanker leher rahim di Indonesia, menunjukkan pentingnya program pencegahan deteksi dini kanker serviks melalui pemeriksaan pap smear. Tujuan penelitian ini untuk mengetahui faktor-faktor yang memengaruhi sikap pemeriksaan pap smear pada wanita usia subur di wilayah kerja Puskesmas Jati. Metode: Kuantitatif dengan pendekatan cross sectional. Jumlah sampel 109 reponden dengan teknik simple random sampling pada wanita usia subur. Hasil: Dukungan petugas kesehatan memengaruhi pemeriksaan pap smear pada wanita usia subur dengan p value= 0,000. Simpulan: Ada pengaruh dukungan petugas kesehatan dengan pemeriksaan pap smear pada perempuan usia subur.
Pengaruh latihan aerobik dan latihan ketahanan terhadap kualitas hidup pada orang dengan HIV/AIDS: A systematic review
Authors: Nursalam Nursalam , Purwanti Sri , Izza Ratu , Apriyanto Yogo
Published: March 2022

Pendahuluan: Angka kejadian penyakit penyerta pada orang dengan HIV/AIDS (ODHA) sangat tinggi, yang disebabkan oleh efek samping terapi antiretroviral (ART), seperti penurunan kualitas hidup (QoL). Kajian review ini bertujuan untuk membahas pengaruh senam aerobik dan latihan ketahanan terhadap kualitas hidup pada ODHA. Metode: Studi diidentifikasi secara sistematis dengan mencari database elektronik Scopus, Science Direct, CINAHL, Pubmed, ProQuest, SAGE selama lima tahun terakhir. Pencarian dengan memanfaatkan mesin pencari diperoleh 232 artikel, dan setelah diseleksi, 14 artikel memenuhi kriteria inklusi. Hasil: Kajian review ini diperoleh bahwa latihan aerobik dan latihan ketahanan berpengaruh positif terhadap indikator kesehatan mental pada ODHA. Kombinasi kedua latihan tersebut dapat meningkatkan kualitas hidup yang berhubungan dengan kesehatan. Simpulan: Dampak positif dari latihan aerobik dan latihan ketahanan terbukti dalam peningkatan kualitas hidup, penurunan morbiditas, dan kematian pada orang yang hidup dengan HIV/AIDS.
Dukungan keluarga pada lansia dengan Diabetes Melitus Tipe II: Literature review
Authors: Arini Hana Nur , Anggorowati Anngorowati , Pujiastuti Rr. Sri Endang
Published: March 2022

Pendahuluan: Diabetes melitus menjadi salah satu masalah kesehatan dunia dimana angka kejadian, komplikasi dan mortalitas lebih tinggi pada kelompok lansia daripada kelompok usia yang lebih muda. Prevalensi kejadian diabetes melitus tipe II pada lansia terus meningkat. Diabetes melitus memerlukan perhatian dalam perawatan bagi penderita dan keluarga. Dukungan keluarga menjadi bagian penting bagi lansia DM dalam mencapai hasil yang optimal. Metode: Pencarian artikel menggunakan database elektronik seperti Google scholar, Science direct, Pubmed dan Proquest. Pencarian artikel yang digunakan yaitu 5 tahun terakhir. Kata kunci yang digunakan diantaranya, “Dukungan Keluarga” dan “Lansia” dan Diabetes Melitus”. Hasil: Hasil: Berdasarkan 11 artikel yang dianalisis, menunjukkan bahwa dukungan keluarga berpengaruh pada praktik manajemen diri meliputi diit DM, perawatan kaki, aktifitas fisik, kontrol gula darah, kepatuhan pengobatan, peningkatan mekanisme koping, efikasi diri, dan kualitas hidup lansia. Simpulan: Dukungan keluarga mempunyai dampak yang positif bagi lansia dengan DM tipe II.
Tingkat pengetahuan ibu menyusui berpengaruh terhadap upaya untuk meningkatkan produksi ASI selama pandemi COVID 19
Authors: Widiastuti Yuni Puji , Ramayanti Eva Dwi
Published: March 2022

Pendahuluan: Nutrisi terbaik bagi bayi adalah ASI, karena ASI memiliki zat gizi yang sangat lengkap dan sesuai dengan kebutuhan bayi terutama bayi 0-6 bulan. Kesuksesan ibu menyusui dipengaruhi oleh multi factor diantaranya adalah umur, pendidikan, pengetahuan dan pengalaman ibu tentang upaya dalam menyusui termasuk didalamnya produksi ASI serta upaya untuk meningkatkan produksi ASI. Kondisi pandemi yang tidak menentu dan penuh kekhawatiran berdampak terhadap timbulnya kecemasan yang dapat menghambat produksi ASI. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan ibu menyusui dengan upaya untuk meningkatkan produksi ASI di masa pandemi. Metode: Penelitian deskriptif korelasional dengan pendekatan crossectional. Populasi dalam penelitian ini adalah ibu menyusui, dengan sampel sebanyak 57 responden yang diambil dengan tehnik concecutive sampling. Analisis data menggunakan statistik deskriptif dan Chi Square. Hasil: Hasil penelitian menunjukkan bahwa hampir keseluruhan responden berada pada usia reproduksi yaitu sebanyak 45 responden (78,9%), tingkat pendididikan SMA dan Perguruan Tinggi yaitu sebanyak 39 responden (68,4%) dan hampir keseluruhan responden memiliki tingkat pengetahuan yang baik tentang upaya meningkatkan produksi ASI yaitu sebanyak 48 responden (84,2%) serta upaya untuk meningkatkan produksi ASI dalam kategori baik sebanyak 40 responden (70,2%). Simpulan: Ada hubungan yang signifikan antara tingkat pengetahuan ibu menyusui dengan upaya untuk meningkatkan produksi ASI dimasa pandemi.
Ambiguous Transliteration of Spanish Letters [t] and [c/q] in Early Aljamiado Manuscript “Poema de Yusuf”
Authors: Tikhonova Oxana Viktorovna
Published: March 2022

The paper aims to reveal the causes of ambiguous Arabic transliteration of Spanish letters [t]
and [c/q] in early Aljamiado manuscript “Poema de Yusuf” (the end of the XIV century). Scientific originality of the study lies in the fact that for the first time in domestic Romance studies the author analyzes orthographic peculiarities of Morisco Aljamiado, reveals the causes of ambiguous transliteration of certain Spa¬nish letters. The findings allow concluding that orthographic ambiguity (tāʾ [t] / ṭāʾ [ṭ], kāf [k] / qāf [q])
is due to phonological changes that occur in Aragonese Spanish in the mentioned period. This conclusion
is also relevant for Mozarabic Aljamiado.
Ethnoculture of the Ingush in Boris Kharsiev’s Russian-Language Creative Work
Authors: Bittirova Tamara Shamsudinovna , Izmailova Tanzila Salmanovna
Published: March 2022

The purpose of the research is to shed light on the range of issues associated with the ethnocultural features of Boris Kharsiev’s creative work. Special attention is paid to the historical discourse that defined the paradigm of the author’s ideological and thematic searches. The paper presents the results of analysing the author’s novellas, short stories and poems, in which the defining concepts are loyalty to the homeland and devotion to ancestral memories. The research is original in that it is the first to reveal the connection between the persona and the author. The research findings have shown the relevance of the ideas contained in B. Kharsiev’s creative work, their significance for understanding processes taking place in society in the post-Soviet decades.
Lexical-Semantic Field with the Key Lexeme “Wealth” (by the Material of Written Sources in the Tatar Language)
Authors: Valieva Mileusha Zakievna
Published: March 2022

The paper aims to reveal the semantics and characteristics of functioning of lexical units in written sources of the 17th-18th centuries in the Tatar language which are included in the lexical-semantic field of the notion “байлык” (wealth) in the functional-semantic aspect. The scientific originality of the research lies in the fact that it describes the lexical-semantic field of the notion “байлык” (wealth) in the texts of the 17th-18th centuries for the first time. The results show that these lexemes in the sources of the 17th-18th centuries reflect the view of the world and the character of the nation, the people’s attitude not only to wealth and life, but also to the Tatar nation’s culture.
Relation between Epistemic Modality and Evidentiality in Turkish and Japanese
Authors: Khafizova Ilseyar Ilgamovna , Khabibullina Elmira Kamilevna
Published: March 2022

The purpose of the research is to identify the features characterising the correlation between epistemic modality and evidentiality in Turkish and Japanese. The relationship between epistemic modality and evidentiality is one of the most ambiguous issues when considering evidentiality. Just as the category of evidentiality manifests itself differently in each language, so the issue of the correlation between epis-temic modality and evidentiality has a special solution in each language. Scientific novelty of the paper lies in conducting a comparative study of the said issue in Turkish and Japanese. We have not found any studies that address the issue of the correlation between epistemic modality and evidentiality in the Japanese and Turkish languages in a comparative aspect. The available research on Japanese or Turkish is often contradictory: the definition of admirativity in Turkish, the identification of markers of epistemic modality and evidentiality in Japanese - these issues cause a lot of controversy. As a result, it has been proved that the interaction of the two categories is particularly evident in the Turkish language when using inferential evidentiality; in the Japanese language, it is the case when it comes to hearsay evidentiality. The inte-raction of the two categories generates a new meaning of evidentiality in the Turkish language, i.e. mirativity.
Influence of an Attitude on the Perception of the Meaning of an English-Language Text during Its Ordinary Reading and Translation into Russian
Authors: Algina Olga Vladimirovna
Published: March 2022

The aim of the paper is to identify the difference in the understanding of the meaning-related and evaluative components of an English-language publicistic text between translators and ordinary readers by conducting an experiment. The research is novel in that it is the first to study how the meaning of a foreign text is perceived by non-native speakers, using the counter text method and involving the whole text; to study and compare the depth of perception of the text by translators / ordinary readers who have or do not have attitudes. The research findings have shown that translators, who have read and translated the text, mentally process the text more deeply at the level of meaning and evaluation, while in the case of ordinary reading, which does not involve any subsequent work with the text, the meaning of the text is mainly reduced to its content.
Feminine Agioanthroponyms in Spanish Paroemias
Authors: Zakharova Liudmila Borisovna , Zakharova Elena Valerievna
Published: March 2022

The paper aims to identify the historical meaning of paroemias (proverbs and sayings) with feminine agioanthroponyms in the Spanish language. The scientific originality of the research lies in the fact that it uses the historical approach to the analysis of paroemiological units with feminine agioanthroponyms for the first time which allows revealing the history of their creation, identifying the semantics, linguocultural features, connotations, transformations. As a result, it has been proved that the history of the Spanish language and culture development is closely connected with the history of the Catholic Christian Church. The study of paroemias with agioanthroponyms allows revealing the history of their development in the Spanish language, as well as identifying religious meanings through semantic characteristics.
The Issue of Historicism in the Reflection of Reality in Bashkir Prose in the First Half of the XX Century
Authors: Gareeva Gulfira Nigamatovna
Published: March 2022

The study aims to shed light on the issue of historicism in the reflection of the new reality in Bashkir prose in the first half of the XX century. Scientific originality of the study lies in identifying national literary epic traditions and innovations, genre and stylistic features of the first Bashkir novels. The attained results have shown that the progression from small forms to large ones, the emergence of the novel as a synthesis of genres and styles were a natural process in the development of Bashkir literature during this period. The experience accumulated in short stories and novellas, in stage works made it possible to turn to depiction of reality in large epic forms. The creation of such novels as A. Tagirov’s “Soldiers”, “Red Guards”, “Red Army Men”, D. Yulty’s “Blood”, I. Nasyri’s “Kudei”, G. Khayri’s “Turn”, H. Davletshina’s “Irgiz” completed one of the stages in the formation of modern literary genres on the national basis.
The PATRIOT Concept in the Focus of Lexicographic Sources in Chinese
Authors: Eremkina Ekaterina Sergeevna , Gofman Tatiana Victorovna
Published: March 2022

The purpose of the research is to identify the cognitive features of the PATRIOT concept belonging to the Chinese national worldview. The paper attempts to provide a lexicographic description of the Chinese PATRIOT concept, using the method of conceptual analysis developed by Z. D. Popova, I. A. Sternin. Scientific novelty of the research lies in the fact that the Chinese PATRIOT concept has not been previously studied using lexicographic methods. As a result, 38 linguistic naming units of the PATRIOT concept have been explicated from lexicographic sources in Chinese, the cognitive interpretation of which helped to identify 8 cognitive features.
Lexical Specificity of the Far Eastern Regiolect
Authors: Mikhajlyukova Natalya Vladimirovna
Published: March 2022

The paper aims to identify lexical features of the Far Eastern regiolect. The article describes the specificity of the Far East, namely, Primorsky Krai residents’ everyday speech practice. The scientific originality of the research lies in the fact that it introduces new regional material: recordings of the Far East residents’ oral speech in the situations of informal communication and epigraphic texts provided an empirical basis for the research. As a result, specific lexemes to mark the Far Eastern regiolect have been identified; the factors which determine these features of the Far East residents’ everyday speech have been revealed.
Structural-Semantic Features of Plasma Physics Terms (by the Material of a Limited Volume Source - an English-Language Academic Paper)
Authors: Nikolaeva Nataliya Sergeevna , Fufurina Tat’yana Alekseevna
Published: March 2022

The study aims to determine the structural-semantic features of English-language terms of the subject area “Plasma Physics”, identified in a text of limited volume (an academic paper). The study is novel in that it is the first to carry out a comparative structural-semantic analysis of plasma physics terms of different lengths. The researchers substantiate the idea that a single paper from a scientific journal is a representative source to select terms and form on their basis a corpus of terms for a structural-semantic analysis. As a result, models of terms of different lengths are identified and compared in the corpus, their part-of-speech and semantic charge correlates with the data obtained by analysing the formal structure of terms of other subject areas, using the material of special dictionaries.
S. Lvova’s Poetry: Modelling Secular Sacredness on the Basis of Transposed Religious Motifs
Authors: Bolshakov Andrey Alexandrovich , Balashova Elena Anatolevna
Published: March 2022

The purpose of the paper is to systematise the main motifs of S. Lvova’s lyrics modelling secular sacredness of modern society, for which the image of the restoration of the world was used. Scientific novelty lies, firstly, in the object of the study itself, since S. Lvova’s creative work has not yet become research material for a literary analysis; secondly, in the identification of poetry’s original feature, i.e. its ability to “accumulate” all realities surrounding people based on the ontological view of the world and man’s place in it. As a result, the image of the “split world” has been considered as central in S. Lvova’s poetry, the main motifs modelling secular sacredness in her lyrics have been identified and classified.
Linguoculturological Comparative Analysis of Legal Terminology in Judicial Practice in the USA and Canada
Authors: Mikheeva Natalya Fedorovna , Dmitrieva Elena Aleksandrovna
Published: March 2022

The purpose of the study is to determine the culture-specific features of legal terminology of the American and Canadian English varieties. A part of the study was devoted to analysing the historical context around the formation of judicial and legal systems in the USA and Canada. Scientific novelty lies in the fact that the comparative analysis of legal terms belonging to genetically similar judicial and legal systems was based on the principle of taking into account the influence of extralinguistic factors on the patterns of functioning of terms; the main parameters of comparison of legal terminology and its classification were determined. As a result of the comparative analysis, it has been proved that the discrepancies concern both the form and the content of the vocabulary in question.
A Comparison of the Thermodynamic and Kinematic Features in Recent Blizzard and Near-Blizzard Events in Iowa
Authors: Power Jennifer L. , Market Patrick S. , Cogil Craig
Published: March 2022

The purpose of this research is to determine the validity of the subjective, anecdotal rule that four isobars present across Iowa during a wintertime, snow-bearing, extratropical cyclone is sufficient to create the winds that attend a blizzard (the “Four Isobar Rule”). Using data from the National Centers for Environmental Information's online Storm Event Database, we identified 15 cases of blizzards in Iowa over the course of 10 years (1999-2009 plus one event in 2010). Subjective analyses of mean sea level pressure for those 15 events revealed an 87% success rate of having four isobars present corresponding with the Blizzard events. Conversely, we also analyzed 23 Near-Blizzard events and discovered that approximately 74% did not have four isobars present. Clearly, there is overlap between these types of events. Composite meteorological fields of both case sets were completed using the North America Regional Reanalysis datasets. The composite results are generally consistent with other recent findings on Iowa blizzards. The surface low is often fairly deep (<1000 hPa), occluded or nearly so, featuring a convergent, descending lower troposphere, with 850-hPa winds of 45 kt or greater, and a near-surface layer whose lapse rate is nearly dry adiabatic. The composites of storms in the Blizzard category are slightly weaker than in prior literature, but the composites of storms in the Near-Blizzard category fail to meet any of the criteria for a blizzard in the state of Iowa.
25 anos de teses e dissertações brasileiras sobre jornalismo na internet
Authors: Engel Bronosky Marcelo , Santos Carmo Cabral Lucas
Published: March 2022

Este artigo apresenta um panorama quantitativo das teses e dissertações sobre jornalismo e transformações tecnológicas entre 1995 e 2019. Através dos dados abertos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes), levantaram-se os termos utilizados nos títulos e palavras-chave com a intenção de identificar tendências, constantes e termos que já não são mais usados. Leva-se em consideração que as palavras enunciam teorias e metodologias dos estudos sobre a convergência tecnológica e o jornalismo. Os dados revelam tendência de uso de termos cada vez mais específicos nas pesquisas e uma ligação entre o surgimento e a popularização de tecnologias e os temas estudados.
О механизмах регулярного ускорения электронов индуцированным электрическим полем в солнечных вспышках
Authors: Цап Юрий Теодорович , Копылова Юлия , Королькова Ольга , Барта Мирослав
Published: March 2022

Проведен критический анализ механизмов регулярного ускорения электронов индуцированными электрическими полями в солнечных вспышках. Показано, что соответствующие модели сталкиваются с трудностями, связанными с поперечным направлением индуцированного электрического поля относительно магнитного, замагниченностью плазмы и малой эффективностью. Делается вывод в пользу важной роли продольных электростатических электрических полей в ускорении электронов.
Integrating of Voice Recognition Email Application System for Visually Impaired Person using Linear Regression Algorithm
Authors: Bristol Glenn Arwin M
Published: March 2022

The outcome of this study will surely help visually impaired people who face difficulties in accessing the computer system. Voice recognition will help them to access email. This study also reduces the cognitive load taken by visually impaired users to remember and type characters using a keyboard. If this system is implemented, self-esteem and social and emotional well-being of the visually impaired users will be lifted up for they will now feel they are being valued in society and has fair treatment and access to technology main function of this study is to use a keyboard of the user that will respond through voice. The purpose of this study is to help a visually impaired person to use the modern application to interact with voice recognition systems with the use of email into different types of modern gadgets, Line computers, or mobile phones. In terms of functionality of the application, the proponents will use a set of APIs,' or Application Program Interface such as Google Speech-to-text and text-to-speech application and it will process through Email System and also the SNMTP or Simple Network Management Protocol will be used for mailing services, in programming software, the proponent will be using PHP for the backend of a web interface. For the creation of a Web Base UI, HTML and CSS will be used. Voice typing and Dictation Speech Interaction models using windows dictation engine. The proponent used a descriptive research design in this study. Descriptive research design is being used by the proponents to describe the characteristics of a population or phenomenon of visually impaired persons being studied. Descriptive research is mainly done because the researchers want to gain a better understanding of a topic. It focuses on providing information that is useful in the development. The research is based on a mixed method focused on producing such informative outcomes that can be used. Based on the results of the surveys, conclusions were drawn: The majority of the respondents were male adultery period ranging from ages 32-41.all are working as massage therapists. The majority of the respondents rated the overall function of the application as Excellent and rated the level of security of the application as Secured.
Formulation and Stability Determination of Anti-Acne Cream Containing Black Cumin Seed Oil and Kaolin Clay
Authors: Santiworakun Najwa Yanya , Dahlan Winai , Arour Zamzam , Plalamee Nasrin , Sirikwanpong Sukrit , Ontao Netnapa , Marpae Marisa , Suksuwan Acharee
Published: March 2022

Acne is the most common skin problem that could occur to any individual. Nigella sativa seed oil and kaolin as natural antimicrobial agents have been utilized in anti-acne cream formulated in this study. This study aimed at the development of anti-acne cream with antimicrobial properties using a crude extract of black cumin (Nigella sativa L.). Anti-acne creams had been formulated from cream-based agents with various percentages of crude black cumin seed extract and 1.0% (w/w) of mineral clay (Kaolin). Physical properties and stability of anti-acne cream at various storage conditions, including incubation at and freeze-thaw at 4, 40, and 45 °C for 28 days. The results showed that developed anti-acne cream containing a crude black cumin seed extract in 0.1 and 1.5% (w/w) had good physical stability. Therefore, the suitable formulation was then tested for anti-Propionibacterium acnes (P. acnes) susceptibility by the broth dilution method. From these results, it was found that 1.0 % (w/w) of crude black cumin seed extract had the ability to inhibit P.acnes with MIC (minimal inhibition concentration) of 15.6 mg/mL.
Biology, Buddhism, and AI: Care as the Driver of Intelligence
Authors: Doctor Thomas , Witkowski Olaf , Solomonova Elizaveta , Duane Bill , Levin Michael
Published: March 2022

Intelligence is a central feature of human beings’ primary and interpersonal experience. Understanding how intelligence originated and scaled during evolution is a key challenge for modern biology. Some of the most important approaches to understanding intelligence are the ongoing efforts to build new intelligences in computer science (AI) and bioengineering. However, progress has been stymied by a lack of multidisciplinary consensus on what is central about intelligence regardless of the details of its material composition or origin (evolved vs. engineered). We show that Buddhist concepts offer a unique perspective and facilitate a consilience of biology, cognitive science, and computer science toward understanding intelligence in truly diverse embodiments. In coming decades, chimeric and bioengineering technologies will produce a wide variety of novel beings that look nothing like familiar natural life forms; how shall we gauge their moral responsibility and our own moral obligations toward them, without the familiar touchstones of standard evolved forms as comparison? Such decisions cannot be based on what the agent is made of or how much design vs. natural evolution was involved in their origin. We propose that the scope of our potential relationship with, and so also our moral duty toward, any being can be considered in the light of Care—a robust, practical, and dynamic lynchpin that formalizes the concepts of goal-directedness, stress, and the scaling of intelligence; it provides a rubric that, unlike other current concepts, is likely to not only survive but thrive in the coming advances of AI and bioengineering. We review relevant concepts in basal cognition and Buddhist thought, focusing on the size of an agent’s goal space (its cognitive light cone) as an invariant that tightly links intelligence and compassion. Implications range across interpersonal psychology, regenerative medicine, and machine learning. The Bodhisattva’s vow ("for the sake of all sentient life, I shall achieve awakening") is a practical design principle for advancing intelligence in our novel creations and in ourselves.
Infant-Directed Speech Does Not Always Involve Exaggerated Vowel Distinctions: Evidence From Danish
Authors: Cox Christopher , Dideriksen Christina , Keren-Portnoy Tamar , Roepstorff Andreas , Christiansen Morten H. , Fusaroli Riccardo
Published: March 2022

The peculiar sound structure of Danish has been argued to reduce the salience of cues that allow infants to extract information from the speech stream. To assess whether caregivers adjust their infant-directed speech (IDS) to accommodate these processing challenges, this study compared the acoustic properties of 26 (100% female, 100% monolingual) Danish caregivers’ spontaneous speech addressed to their 11-24-month-old infants and an adult experimenter. The data were collected between 2016-2018 in Aarhus, Denmark. Prosodic properties of Danish IDS conformed to cross-linguistic patterns, with a higher pitch, greater pitch variability and slower articulation rate than ADS. Crucially, though, vocalic properties contradicted cross-linguistic tendencies: Danish IDS was produced with a reduced or similar vowel space, higher within-vowel variability, and lower degree of vowel discriminability than ADS.
Forty-eight classical moral dilemmas in Persian language: A validation and cultural adaptation study
Authors: Sojoudi Sajad , Jahanitabesh Azra , Hatami Javad , Christensen Julia F.
Published: March 2022

Moral dilemmas are a useful tool to investigate empirically, which parameters of a given situation modulate participants’ moral judgment, and in what way. In an effort to provide moral judgment data from a non-WEIRD culture, we provide the translation and validation of 48 classical moral dilemmas in Persian language. The translated dilemma set was submitted to a validation experiment with N=82 Iranian participants. Data from Iranian participants confirmed the four-factor structure of this dilemma set including Personal Force (Personal, Impersonal), Benefit Recipient (Self, Other), Evitability (Avoidable, Inevitable), and Intentionality (Accidental, Instrumental). When comparing moral judgments of Iranian participants to those of Spanish and Italian participants’ from previous research with the same dilemma set, differences emerged. Iranian participants’ moral judgments were more deontological (i.e., they refrained from harm), than Spanish and Italian participants. Religiosity made participants’ moral judgments more deontological, and also dysphoric mood resulted in a more deontological response style.
Context predicts commonsense notions of object similarity
Authors: Magri Caterina , Elmoznino Eric , Bonner Michael F.
Published: March 2022

What makes objects alike in the human mind? Computational approaches for characterizing object similarity have largely focused on the visual forms of objects or their linguistic associations. However, intuitive notions of object similarity may depend heavily on contextual reasoning—that is, objects may be grouped together in the mind if they occur in the context of similar scenes or events. Using large-scale analyses of natural scene statistics and human behavior, we found that a computational model of the associations between objects and their scene contexts is strongly predictive of how humans spontaneously group objects by similarity. Specifically, we learned contextual prototypes for a diverse set of object categories by taking the average response of a convolutional neural network (CNN) to the scene contexts in which the objects typically occurred. In behavioral experiments, we found that contextual prototypes were strongly predictive of human similarity judgments for a large set of objects and rivaled the performance of models based on CNN representations of the objects themselves or word embeddings for their names. Together, our findings reveal the remarkable degree to which context alone predicts commonsense notions of object similarity in the human mind.
The Role of Derivation in Teaching Quranic Vocabulary: Between Theory and Practice
Authors: Hefny Rabie Mohamed , Abdelgelil Mohamed Fathy Mohamed , Osman Ammar Kamal Ibrahim , Hassan Isyaku
Published: March 2022

Words with close meanings often cause difficulty in understanding the meanings of Quranic text. At times, Quranic words with similar meanings are even used in the wrong context. As such, understanding the morphological and semantic differences between Quranic words with close meanings becomes necessary. Therefore, this research aims to explore the roots and semantic differences of Quranic words with similar meanings and ascertain the role of derivation in teaching Quranic vocabulary. The research employed the descriptive-analytical approach to trace Quranic words with similar connotations and determine their derivation methods. The findings showed that the etymological origins of Quranic vocabulary with similar meanings can help greatly in clarifying the semantic features of the words. Similarly, the findings revealed that referring to the morphological structures of words helps to discover the meanings of Quranic words with similarity in linguistic origin and difference in structure. Therefore, derivation can be an effective means of determining the connotations of Quranic words, which can be useful in teaching Quranic vocabulary. This research could help instructors to advance the method of teaching Quranic vocabulary as well as the Arabic language in general. Nevertheless, the research is limited to the role of derivation in teaching Quranic vocabulary, and thus, further studies may focus on how the origin and formation of words can help students to develop language skills.
Race and Identity in Brit Bennett’s The Vanishing Half
Authors: Areqi Rashad Mohammed Moqbel Al
Published: March 2022

Race and identity transformation have been overarching themes in the works of African American writers. Brit Bennett’s The Vanishing Half (2020) is one fictional work that deals with identical twin sisters: Desiree and Stella Vignes. They are two light-skinned Black sisters who have chosen or rebuilt their identities based on the needs that allow them to live in peace among their communities. This study attempts to trace the importance of race and identity for the African Americans through exploring the lives of these twin sisters who leave their hometown. Through postcolonial critical concepts of identity and race, this research sheds light on the reasons behind the sisters’ decisions to keep or shed their Black identity, as well as their community’s influence on their decision to leave their hometown. This study found that the choices of race and identity the sisters made earlier in their lives identified their fate and established a path for their children. Desiree prefers to maintain her identity by marrying a Black man, and Stella sees her interest in marrying a White man and keeping her past hidden. Kennedy, Stella’s daughter with a White man, and Jude, Desiree’s daughter with a Black man, adhere to their parent’s beliefs regarding race and identity. However, Stella and Desiree still long for their origin and home, and ultimately, they gather again at home they left together.
Narrative Aspects of the Novels by Lucy Maud Montgomery and Eleanor Porter
Authors: Lysanets Yuliia , Nikolenko Olha , Kokhan Roksoliana , Nikolenko Kateryna
Published: March 2022

The metamodernist mood of the modern era increasingly clearly correlates with the transformation of literary methodologies and methods of reading, analysis, and interpretation of literary texts. The study of the genre specificity of the novel is one of the essential segments of the latest scientific studies, given its flexibility and significant textual representation in various national works of literature. This paper offers a critical review of the key stages in the history of the study of the novel as a literary genre, as well as shows the possibilities of understanding the poetic aspects of the author’s style. The material of the research relies on the novels by the Canadian writer Lucy Maud Montgomery and the US writer Eleanor Porter. Both authors belonged to the same historical and cultural era; their work has many typological parallels due to objective factors. At the same time, the modernist worldview was embodied in each stylistic manner in its own way. Comparison of individual styles makes it possible to carry out a typological analysis within a particular genre with access to the study of common sources of image creation, as well as modeling the interpretive paradigm of metamodernism in the projection on the literature of different historical periods taking into account national characteristics. At the same time, the research opens up the prospect of expanding the methodological horizons of narratology for its progress beyond its “boundaries”: outside of literary studies, in a significant context, as well as in space outside of fiction.
Cephalothin as a Carrier of 6-Mercaptopurine for Targeting Cancer Tissues
Authors: H. Mohammad Mohammad , J.Al-Karagully Haider
Published: March 2022

A lower extracellular pH is one of the few well-documented physiological differences between tumour and normal tissues. On the other hand, elevated glutathione (GSH) level has been detected in many tumours compared with healthy surrounding tissues. The compound II: 3-(9H-purin-6-yl-thio) carbonothionyl methyl-8-oxo-7-(2-thiophen-2-yl) acetamido-5-thia-1-azabicyclo-4-octo-ene-carboxylic acid was a cephalothin derivative contain 6-mercaptopurine (6-MP). Compound II react with general base catalysis in slightly acidic pH or with sulfhydryl nucleophiles to release the chemotherapeutic drug 6-MP. The generation of compound II was accomplished following multistep reaction procedures. The structure of compound II and its intermediate was confirmed by their melting point, infrared spectroscopy, CHN and NMR analysis. The hydrolysis of compound II in aqueous buffer solution of pH 6 and in the presence of GSH at pH 7.4 was studied. The partition coefficient (PC) of compound II was also determined. Compound II has acceptable rate of hydrolysis at slightly acidic medium pH 6 (t1/2 = 56.34 min.) and 80% of compound II had been converted to 6-MP within 30 min in the presence of GSH. And the compound has acceptable stability at pH 7.4(t0.5=639.65 min.) and the rate of hydrolysis was effected by change the buffer concentration.  This compound can selectively deliver 6-MP into the tumour tissues which have acidic pH or elevated GSH level. Compound II had an improved PC value of 12.23 compared to 1.22 for free drug 6-MP confirming higher lipophilicity.

Key words: 6-mercaptopurine, cancer, prodrug, targeting
Single Dose Antibiotic Prophylaxis in Outpatient Oral Surgery Comparative Study
Authors: Y. Alhamdani Fadia , Y.Alhamdani Faaiz
Published: March 2022

It is clear that correct application of antibiotic prophylaxis can reduce the incidence of infection  resulting from the bacterial  inoculation in a variety of clinical situations; it cannot   prevent  all  infections  any  more  than it  can   eliminate  all  established infections. Optimum  antibiotic   prophylaxis  depends on:  rational  selection  of the drug(s),  adequate  concentrations  of the  drug  in  the  tissues that  are at risk, and attention to  timing  of  administration.  Moreover,  the  risk  of  infection  in  some situations  does not outweigh  the risks which  attend the administration of even the safest antibiotic drug. The aim of this study was to compare between 2 prophylactic protocols  in  out  patients  undergoing  oral  surgical  procedures.  Thirty   patients, selected from the attendants of oral surgery clinic in Al-Karamah Dental Center, were subjected to different oral surgical procedures under local  anesthesia. These patients were given single dose antibiotic  prophylaxis in 2 groups; 1st group were 15 patients given 1 million i.u. of procaine  penicillin  I.M. 30 minutes  before oral  surgery, 2nd group were 15 patients given 600mg clindamycin orally 1 hours before oral surgery. The  maximum  time  for  all  procedures  was 2 hours. There  was  no  difference between  procaine  penicillin  (1 million i.u.), and  clindamycin (600mg),  regimens concerning post operative infection in out patientâ€™s oral surgical procedures.

Key words: Antibiotic prophylaxis, outpatient oral surgery
Cytotoxic Assay of Nigella sativa Leaf Callus Extract (Thymol) on Hep-2 Cell Line Using ELISA Assay
Authors: S. Abdel Gany Zaynab , F. Mahdi Mayasaa
Published: March 2022

Extract from cell culture of medicinal plant like Nigella sativa have been assessed for its cytotoxic properties. Thymol is likely responsible for the theraputic effects of  Nigella sativa leaf callus extract. In this short study the inhibitory effect of Nigella sativa leaf callus extract (Thymol) has been studied on Human Lorgnx Epidrmoid Carcinoma (Hep-2) cell line during different exposure period of time (24, 48 and 72 hrs.) using different concentration of the extract (1000, 500, 400, 300, 200 and 100 Âµg/ml). The optical density of the Hep-2 cells has been readed on 492 nm wave length. Thymol â€“induced cytotoxicity was (500 Âµg/ml) which inhibit cell growing compared to the control and this ratio increased at the 48 hrs of exopsure and stopped at 72 hrs.

Key wards: Nigella sativa, callus extract, cell line, ELISA assay.
A Fan through the Ages: Layers of Adaptation in SITI Company’s Hanjo
Authors: Samur Sebastian X
Published: March 2022

The love tale of Hanjo, presented by SITI Company in New York in 2017, traces its history back through the plays and dramatic treatises of Yukio Mishima and Zeami Motokiyo to a young maid (and eventual poet), Ban Jieyu, in ancient China. Informed by Andrew Sofer’s theory of the prop, this article uses the story’s central metaphor of a fan – which, like the protagonist, is cherished in summer but loses its value in autumn – to trace the tale’s adaptations, illuminating how with each reworking the central prop gains ever more complex meanings. As the tale undergoes numerous treatments, the original heteronormative context of Ban Jieyu’s romantic relationship becomes increasingly less straightforward as Mishima introduces taboo eroticism and SITI Company plays with gender roles, suggesting a woman with multiple non-normative possibilities for love. By analysing the evolution of Hanjo’s fan, this essay extends Sofer’s theory to consider the possibilities of a prop whose signification is not limited to a specific historical period but takes on new meanings when staged within a postdramatic production.
Hélène Lecossois. Performance, Modernity and the Plays of J.M. Synge
Authors: Walsh Ian R.
Published: March 2022

Building on the insights of performance studies, Performance, Modernity and the Plays of J.M. Synge offers a fresh examination of Synge’s plays, exploring them in relation to embodied cultural practices and material culture to reveal how they are at once both indicative of and resistant to the commodity culture of capitalist modernity.
Michael Mckinnie. Theatre in Market Economies
Authors: Maley Patrick
Published: March 2022

Theatre in Market Economies argues convincingly that theatre is embedded in the market-driven, political culture of the contemporary United Kingdom, United States, Canada, and Northern Ireland. Through careful analysis of case studies drawn from theatre and its social activity, Michael McKinnie shows theatre as a cultural entity participating actively in a mixed economy.
Bradley Rogers. This Song Is You: Musical Theatre and the Politics of Bursting into Song and Dance
Authors: O’Leary James
Published: March 2022

Rogers’s This Song Is You places the sensuous body at the centre of both historical and critical inquiry about Broadway. He argues that “formal integration,” comprising a discourse of unity, was a defensive reaction against erotic spectacle. In doing so, this book often offers fresh ideas for further historical research.
The reinvention of Canadian tort law, 1945–95:Jordan Houseas case study
Authors: Kostal Rande , Chamberlain Erika
Published: March 2022

This article employs the case study method to investigate the social history of Canadian tort law and litigation after 1945. Its focus is Menow v Jordan House, the stem precedent of the Canadian common law of tavern-keeper liability for intoxicated patrons. The article examines the historical genesis, pleading, and adjudication of this litigation, probing why – in Canada in the late 1960s and early 1970s – the novel tort claim of an ejected intoxicant against a vendor of alcohol not only was imagined, discussed, and commenced but also was won by the plaintiff at three levels of court. The authors argue that the Jordan House lawsuit exemplified a pivotal moment of socio-legal discontinuity in Canada, portending a quarter century of change in three major facets of its tort law system: in the perceptions of lay persons with respect to their private legal rights and obligations; in the personal convictions, social geography, and litigation strategies of Canadian lawyers; and in the formulation of tort doctrine by Canada’s trial and appellate judges. The article is a sub-study of a larger project on the reinvention of tort law and litigation in Canada in the half-century after World War II.