bluuebunny/crossref_metadata_2025 huggingface dataset:
The Materiality and Heritage of Contemporary Forced Migration
Authors: McGuire Randall H.
Published: July 2020

Fleeing violence, poverty, abuse, war, and climatic change, tens of millions of people have fled their homes in the Global South seeking refuge in adjacent nations and in the Global North. This modern migration entails a material, sensual experience in time. The craft of archaeology has traditionally engaged with the material, the sensual, and the temporal. Archaeologists who study the materiality of modern undocumented migration embrace activist-engaged research that applies the craft of archaeology to the contemporary world. They study the materiality of migration to reveal and comprehend the lived experience of displaced persons. They seek to understand the barriers erected to that journey, the things migrants acquire and leave on the trail, migrant placemaking, their stranded lives, how they build new lives, what the migrants have left behind in their home countries, and the heritage of forced migration. They approach this work in critical solidarity with displaced peoples.
Molecular signatures of muscle growth and composition deciphered by the meta-analysis of age-related public transcriptomics data
Authors: Bazile Jeanne , Jaffrezic Florence , Dehais Patrice , Reichstadt Matthieu , Klopp Christophe , Laloe Denis , Bonnet Muriel
Published: July 2020

The lean-to-fat ratio is a major issue in the beef meat industry from both carcass and meat production perspectives. This industrial perspective has motivated meat physiologists to use transcriptomics technologies to decipher mechanisms behind fat deposition within muscle during the time course of muscle growth. However, synthetic biological information from this volume of data remains to be produced to identify mechanisms found in various breeds and rearing practices. We conducted a meta-analysis on 10 transcriptomic data sets stored in public databases, from the longissimus thoracis of five different bovine breeds divergent by age. We updated gene identifiers on the last version of the bovine genome (UCD1.2), and the 715 genes common to the 10 studies were subjected to the meta-analysis. Of the 238 genes differentially expressed (DEG), we identified a transcriptional signature of the dynamic regulation of glycolytic and oxidative metabolisms that agrees with a known shift between those two pathways from the animal puberty. We proposed some master genes of the myogenesis, namely MYOG and MAPK14, as probable regulators of the glycolytic and oxidative metabolisms. We also identified overexpressed genes related to lipid metabolism (APOE, LDLR, MXRA8, and HSP90AA1) that may contribute to the expected enhanced marbling as age increases. Lastly, we proposed a transcriptional signature related to the induction (YBX1) or repression (MAPK14, YWAH, ERBB2) of the commitment of myogenic progenitors into the adipogenic lineage. The relationships between the abundance of the identified mRNA and marbling values remain to be analyzed in a marbling biomarkers discovery perspectives.
Regularity of Commutators of the One-Sided Hardy-Littlewood Maximal Functions
Authors: Zhang Daiqing
Published: July 2020

In this paper, the regularity properties of two classes of commutators of the one-sided Hardy-Littlewood maximal functions and their fractional variants are investigated. Some new bounds for the derivatives of the above commutators and the boundedness and continuity for the above commutators on the Sobolev spaces will be presented. The corresponding results for the discrete analogues are also considered.
Functional Geominimal Surface Area and Its Related Affine Isoperimetric Inequality
Authors: Fang Niufa , Yang Jin
Published: July 2020

The first variation of the total mass of log-concave functions was studied by Colesanti and Fragalà, which includes the Lp mixed volume of convex bodies. Using Colesanti and Fragalà’s first variation formula, we define the geominimal surface area for log-concave functions, and its related affine isoperimetric inequality is also established.
Association of Tooth Loss with New-Onset Parkinson’s Disease: A Nationwide Population-Based Cohort Study
Authors: Woo Ho Geol , Chang Yoonkyung , Lee Ji Sung , Song Tae-Jin
Published: July 2020

Introduction. Tooth loss is associated with poor oral hygiene. During insufficient oral sanitation, focal infection and inflammation can occur and these reactions may induce systemic inflammation. Systemic inflammatory reaction may be related to the degeneration of dopamine neurons in the substantia nigra. We hypothesized that tooth loss is related to increased risk of new-onset Parkinson’s disease. Methods. Between 2003 and 2006, we included 153,165 participants from the national health insurance system-health screening cohort in Korea. The incidence of new-onset Parkinson’s disease was defined as International Classification of Diseases-10 code “G20,” accompanying the prescription records for any anti-Parkinson’s disease medication. Results. Approximately 19.9% of the included participants had periodontal disease. After a median duration of 10.4 years, 1,227 (0.8%) cases of new-onset Parkinson’s disease were noted. The number of tooth loss was positively related to an increased risk of new-onset Parkinson’s disease. Contrastingly, the frequency of tooth brushings and dental clinic visits for any causes as well as competent dental care were negatively related to the development of new-onset Parkinson’s disease. In multivariable analysis, the number of tooth loss (≥15) was positively related to new-onset Parkinson’s disease development (hazard ratio: 1.38, 95% confidence interval (1.03–1.85), p=0.029, p for trend = 0.043) after adjusting variables. Conclusion. Our study demonstrated that the number of tooth loss was positively correlated with a higher risk of new-onset Parkinson’s disease development in a longitudinal study setting. Increased number of tooth loss may be an important risk indicator of new-onset Parkinson’s disease.
Sequential Delivery of BMP2-Derived Peptide P24 by Thiolated Chitosan/Calcium Carbonate Composite Microspheres Scaffolds for Bone Regeneration
Authors: Wang Zhaozhen , Liu Xujie , Martin Vidmi Taolam , Abdi Mohamed Abdullahi , Chen Lijun , Gong Yong , Yan Yiran , Song Liming , Liu Zhongxun , Zhang Xianliao , Chen Yan , Yu Bo
Published: July 2020

The combination of tissue-engineered bone scaffolds with osteogenic induction molecules is an important strategy for critical-sized bone defects repair. We synthesized a novel thiolated chitosan/calcium carbonate composite microsphere (TCS-P24/CA) scaffold as a carrier for bone morphogenetic protein 2- (BMP2-) derived peptide P24 and evaluated the release kinetics of P24. The effect of TCS-P24/CA scaffolds on the proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs) was evaluated by scanning electron microscope (SEM), CCK-8, ALP assay, alizarin red staining, and PCR. A 5 mm diameter calvarial defect was created, then new bone formation was evaluated by Micro-CT and histological examination at 4 and 8 weeks after operation. We found the sequential release of P24 could last for 29 days. Meanwhile, BMSCs revealed spindle-shaped surface morphology, indicating the TCS-P24/CA scaffolds could support cell adhesion and mRNA levels for ALP, Runx2, and COL1a1 were significantly upregulated on TCS-10%P24/CA scaffold compared with other groups in vitro (p<0.05). Similarly, the BMSCs exhibited a higher ALP activity as well as calcium deposition level on TCS-10%P24/CA scaffolds compared with other groups (p<0.05). Analysis of in vivo bone formation showed that the TCS-10%P24/CA scaffold induced more bone formation than TCS-5%P24/CA, TCS/CA, and control groups. This study demonstrates that the novel TCS-P24/CA scaffolds might contribute to the delivery of BMP2-derived Peptide P24 and is considered to be a potential candidate for repairing bone defects.
A Systematic Review of Healthcare Big Data
Authors: Raja Rakesh , Mukherjee Indrajit , Sarkar Bikash Kanti
Published: July 2020

Over the past decade, data recorded (due to digitization) in healthcare sectors have continued to increase, intriguing the thought about big data in healthcare. There already exists plenty of information, ready for analysis. Researchers are always putting their best effort to find valuable insight from the healthcare big data for quality medical services. This article provides a systematic review study on healthcare big data based on the systematic literature review (SLR) protocol. In particular, the present study highlights some valuable research aspects on healthcare big data, evaluating 34 journal articles (between 2015 and 2019) according to the defined inclusion-exclusion criteria. More specifically, the present study focuses to determine the extent of healthcare big data analytics together with its applications and challenges in healthcare adoption. Besides, the article discusses big data produced by these healthcare systems, big data characteristics, and various issues in dealing with big data, as well as how big data analytics contributes to achieve a meaningful insight on these data set. In short, the article summarizes the existing literature based on healthcare big data, and it also helps the researchers with a foundation for future study in healthcare contexts.
Single-Actuator-Based Lower-Limb Soft Exoskeleton for Preswing Gait Assistance
Authors: Hsieh Ming-Hwa , Huang Yin Hsuan , Chao Chia-Lun , Liu Chien-Hao , Hsu Wei-Li , Shih Wen-Pin
Published: July 2020

In this research, we proposed a lower-limb soft exoskeleton for providing assistive forces to patients with muscle weakness during the preswing phase of a gait cycle. Whereas conventional soft exoskeletons employ two motors to assist each leg individually, we designed a single motor for actuation. Our design assists hip flexion for light weights and prevents some slip problems that can arise from rotary motors. The actuation mechanism was based on a pulley system that converted the power supplied by the single motor into linear reciprocating motions of a slider. When the single motor rotated, the slider moved linearly, first in one direction and then in the opposite direction. The slider pulled knee braces through cables with an assistive force of 100 N. The actuation was triggered when the system detected that the backward swing of the wearer’s thigh had ended. A prototype was designed, fabricated, and examined with 7 subjects (average age, 24). Subjects were measured while they wore our exoskeleton in power-off and power-on modes. Comparisons proved that wearing the exoskeleton caused a negligible deviation of gait, and that the soft exoskeleton could reduce metabolic cost during walking. The research results are expected to be beneficial for lightweight soft exoskeletons and integration with exosuits that provide assistive forces through the wearer’s entire gait.
Multi-Innovation Stochastic Gradient Parameter and State Estimation Algorithm for Dual-Rate State-Space Systems with d-Step Time Delay
Authors: Gu Ya , Zhu Quanmin , Liu Jicheng , Zhu Peiyi , Chou Yongxin
Published: July 2020

This paper presents a multi-innovation stochastic gradient parameter estimation algorithm for dual-rate sampled state-space systems with d-step time delay by the multi-innovation identification theory. Considering the stochastic disturbance in industrial process and using the gradient search, a multi-innovation stochastic gradient algorithm is proposed through expanding the scalar innovation into an innovation vector in order to obtain more accurate parameter estimates. The difficulty of identification is that the information vector in the identification model contains the unknown states. The proposed algorithm uses the state estimates of the observer instead of the state variables to realize the parameter estimation. The simulation results indicate that the proposed algorithm works well.
Association of Hypertension and Lipid Profile with Osteoporosis
Authors: Al-Hariri Mohammed , Aldhafery Bander
Published: July 2020

Background. Hypertension (HTN) and osteoporosis (OP) are common diseases that adversely affect the health-related quality of life among the elderly. However, there is a scarcity of literature on the association between HTN and OP.Objective. The aims of this study were to investigate the association between HTN and antihypertensive drugs (AHT), with bone mineral density (BMD)T-scores, as well as to determine the status of bone quality in Saudi Arabia.Method. A retrospective study was conducted at King Fahd Hospital of the University, Khobar, Saudi Arabia, during 2016 to 2018. BMD was measured using dual-energy X-ray absorptiometry (DEXA).T-score values were used for the diagnosis of osteoporosis. HTN diagnosis and medications, laboratory, and radiology results were collected from the hospital record system.Results. Out of 1332 extracted profiles, 1103 (82.8%) were females. Based on theT-score, the majority of patients either had osteopenia (41.1%) or was osteoporotic (27.8%). The present study found that there is a significant increase in serum lipids and alkaline phosphatase (ALP) in the osteoporotic group when compared with normal and osteopenia groups. Furthermore, it was found that ALP and Ca levels were significant predictors for OP. Pearson’s correlation test revealed a significant negative correlation between HTN and BMDT-score. However, the study reported a nonsignificant association between AHT and BMDT-score.Conclusion. We conclude that controlling both HTN and dyslipidemia might improve bone health. Every osteoporotic patient should be screened for dyslipidemia. Early detection and appropriate management for OP are highly recommended in Saudi Arabia, especially amongst the high-risk group.
Water‐Cement‐Density Ratio Law for the 28‐Day Compressive Strength Prediction of Cement‐Based Materials
Authors: Li Siqi , Yang Jinbo , Zhang Peng
Published: July 2020

In the present contribution, the water‐cement‐density ratio law for the standard curing 28‐day compressive strength of cement‐based materials including grout, normal concrete, ceramsite concrete, and foamed concrete is proposed. The standard curing 28‐day compressive strength of different grouts, normal concrete, ceramsite concrete, and foamed concrete was tested. Simulations for Abrams’ law, Bolomey’s formula, and water‐cement‐density ratio law were carried out and compared. The water‐cement‐density ratio law illustrates better simulations for the prediction of the 28‐day compressive strength of cement‐based materials. The water‐cement‐density ratio law includes both the water‐cement ratio and relative apparent density of the cement‐based material. Relative apparent density of the cement‐based material is an important one of all the factors determining the compressive strength of the cement‐based material. The water‐cement‐density ratio law will be beneficial for the precise and generalized prediction of the 28‐day standard curing compressive strength of cement‐based materials.
Microencapsulation Delivery System in Food Industry—Challenge and the Way Forward
Authors: Yang Mingyi , Liang Ze , Wang Lei , Qi Ming , Luo Zisheng , Li Li
Published: July 2020

Microencapsulation is a promising technique, which provides core materials with protective barrier, good stability, controlled release, and targeting delivery. Compared with the pharmaceutical, cosmetic, and textile industries, food processing has higher requirements for safety and hygiene and calls for quality and nutrition maintenance. This paper reviews the widely used polymers as microcapsule wall materials and the application in different food products, including plant-derived food, animal-derived food, and additives. Also, common preparation technologies (emphasizing advantages and disadvantages), including spray-drying, emulsification, freeze-drying, coacervation, layer-by-layer, extrusion, supercritical, fluidized bed coating, electrospray, solvent evaporation, nanocapsule preparation, and their correlation with selected wall materials in recent 10 years are presented. Personalized design and cheap, efficient, and eco-friendly preparation of microcapsules are urgently required to meet the needs of different processing or storage environments. Moreover, this review may provide a reference for the microencapsulation research interests and development on future exploration.
TAD-HOC Routing Protocol for Efficient VANET and Infrastructure-Oriented Communication Network
Authors: Sadakale Ranjit , Ramesh N. V. K. , Patil Rajendrakumar
Published: July 2020

Intelligent Transportation System (ITS) is a critical factor for Vehicular Ad hoc Networks (VANET). Even though VANET belongs to the class of Mobile Ad hoc Network (MANET), none of the MANET routing protocol applies to VANET. VANET network is dynamic, due to increased vehicle speed and mobility. Vehicle mobility of VANET affects conventional routing algorithm performance, which deals with the dynamicity of the network node. The evaluation of the existing research stated that Ad hoc On-Demand Distance Vector (AODV) is an effective MANET protocol to adopt network changes for significant resource utilization and also provides effective adaptation in the network change. Due to the effective performance of the AODV protocol, it is considered as an effective routing protocol for VANET. This paper proposed an ad hoc TROPHY (TAD-HOC) routing protocol for the VANET network for increasing efficiency and effective resource utilization of the network. To improve the overall performance, ad hoc network is combined with Trustworthy VANET ROuting with grouP autHentication keYs (TROPHY) protocol. The proposed TAD-HOC protocol transmits data based on time demand in the VANET network with the desired authentication. Results of the proposed approach show the increased performance of the VANET network with packet delay, transmission range, and end-to-end delay. The comparative analysis of the proposed approach with I-AODV, AODV-R, and AODV-L shows that the proposed TAD-HOC exhibited effective performance.
Pneumocystis jirovecii Pneumonia in a HIV-Infected Patient with a CD4 Count Greater Than 400 Cells/μL and Atovaquone Prophylaxis
Authors: Sullivan Abigayle , Lanham Theresa , Krol Ronald , Zachariah Shilla
Published: July 2020

We describe a rare case of Pneumocystis jirovecii pneumonia (PCP) in a heterosexual man with a pertinent medical history of well-controlled human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and PCP prophylaxis with atovaquone. The patient presented with recurrent shortness of breath, worsening malaise, and fever, following treatment for hypersensitivity pneumonitis one month prior, including a twenty-four-day course of 40 milligrams daily glucocorticoid with taper. However, transbronchial biopsies, lavage, and cytology from prior admission were inconclusive. The patient refused video-assisted thoracic surgery (VATS) at that time. Upon readmission, bronchoscopy with right VATS and lung biopsy were performed. Grocott’s methenamine silver stain of right lung biopsy was positive for Pneumocystis jirovecii. This case is a rare example of PCP in a patient with a normal CD4 count (>487 cells/μL) and a low viral load (<20 copies/mL) despite PCP prophylactic antibiotics in the setting of recent iatrogenic immunosuppression.
Fractal Dynamics and Control of the Fractional Potts Model on Diamond-Like Hierarchical Lattices
Authors: Sun Weihua , Liu Shutang
Published: July 2020

The fractional Potts model on diamond-like hierarchical lattices is introduced in this manuscript, which is a fractional rational system in the complex plane. Then, the fractal dynamics of this model is discussed from the fractal viewpoint. Julia set of the fractional Potts model is given, and control items of this fractional model are designed to control the Julia set. To associate two different Julia sets of the fractional model with different parameters and fractional orders, nonlinear coupling items are taken to make one Julia set change to another. The simulations are provided to illustrate the efficacy of these methods.
ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader–Follower Relationship That Drives Collective Invasion
Authors: Westcott Jill M. , Camacho Sharon , Nasir Apsra , Huysman Molly E. , Rahhal Raneen , Dang Tuyen T. , Riegel Anna T. , Brekken Rolf A. , Pearson Gray W.
Published: July 2020

Defining how interactions between tumor subpopulations contribute to invasion is essential for understanding how tumors metastasize. Here, we find that the heterogeneous expression of the transcription factor ΔNp63 confers distinct proliferative and invasive epithelial-to-mesenchymal transition (EMT) states in subpopulations that establish a leader–follower relationship to collectively invade. A ΔNp63-high EMT program coupled the ability to proliferate with an IL1α- and miR-205–dependent suppression of cellular protrusions that are required to initiate collective invasion. An alternative ΔNp63-low EMT program conferred cells with the ability to initiate and lead collective invasion. However, this ΔNp63-low EMT state triggered a collateral loss of fitness. Importantly, rare growth-suppressed ΔNp63-low EMT cells influenced tumor progression by leading the invasion of proliferative ΔNp63-high EMT cells in heterogeneous primary tumors. Thus, heterogeneous activation of distinct EMT programs promotes a mode of collective invasion that overcomes cell intrinsic phenotypic deficiencies to induce the dissemination of proliferative tumor cells.

Significance:

These findings reveal how an interaction between cells in different EMT states confers properties that are not induced by either EMT program alone.
Determinants of Clinical COPD Questionnaire in Patients with COPD: A Cross-Sectional Observational Study
Authors: Zhou Zijing , Zhou Aiyuan , Peng Yating , Duan Jiaxi , Zeng Yuqin , Zhao Yiyang , Cheng Wei , Chen Ping
Published: July 2020

Background: The Clinical COPD Questionnaire (CCQ) has been suggested by the Global Initiative of Chronic Obstructive Lung Disease (GOLD) as a comprehensive symptom measurement tool, which helps to classify patients in order to direct pharmacological treatment. Therefore, it is essential to understand its determinants. Objectives: To identify the determinants of the overall CCQ score and scores of its 3 subdomains among chronic obstructive pulmonary disease (COPD) patients from China. Methods: A total of 1,241 COPD patients in the outpatient department of the Second Xiangya Hospital in China were recruited. Basic information and clinical data were collected. Differences in the GOLD categories based on Modified Medical Research Council Dyspnea Scale (mMRC), COPD Assessment Test (CAT), and CCQ were compared. Multiple linear regression analyses were performed to evaluate determinant factors of the total CCQ and subdomain scores. Results: The total CCQ and/or separate domain scores significantly differed with sex, age, BMI, smoking status, biomass fuel exposure, exacerbation frequency, mMRC, CAT, and GOLD grades and groups. Subjects with asthma-COPD overlap (ACO) had worse health status based on CCQ than those with COPD alone. As for the 16 subgroups based on GOLD 2017, statistical differences in the total CCQ and functional domain scores were found among subgroups 1A–4A, 1B–4B, and 1D–4D. The mMRC classified much more patients into more symptom groups than CAT and CCQ. No significant difference was observed in the GOLD categories between the CAT and CCQ (cut point = 1.5). Multiple linear regression analysis showed that smoking status, underweight, ACO, post-bronchodilator FEV1% predicted <50%, exacerbation history, and mMRC were independently associated with the total CCQ score. Only 3 variables were significantly associated with the symptom domain: ACO, exacerbations, and mMRC; for the functional domain, age ≥75 years, ACO, post-bronchodilator FEV1% predicted <50%, exacerbation history, and mMRC were significant; female sex, underweight, frequent exacerbations (≥2), and mMRC were significantly associated with higher scores in the mental domain. Conclusions: The classification of COPD produced by mMRC, CAT, and CCQ was not identical. Smoking status, underweight, ACO, post-bronchodilator FEV1% predicted <50%, exacerbation history, and mMRC were associated with lower health-related quality of life assessed by the total CCQ score, while different subdomains of CCQ had different determinant factors.
A Family with Gitelman Syndrome with Asymptomatic Phenotypes while Carrying Reported SLC12A3 Mutations
Authors: Ishikawa Moena , Tada Yumi , Tanaka Hiromu , Morii Wataru , Inaba Masako , Takada Hidetoshi , Mori Takayasu , Noguchi Emiko
Published: July 2020

Gitelman syndrome (GS) is an autosomal recessive disorder characterized by alkalosis, hypokalemia, and hypomagnesemia. Although hundreds of genetic variants associated with GS have been reported, many of them are categorized as of uncertain significance in ClinVar. Here, we describe a pediatric GS patient from a three-generation family whose mother and maternal grandmother were asymptomatic. The proband was a 16-year-old Japanese girl with muscle weakness and continuous hypokalemic metabolic alkalosis. The patient, her mother, and her maternal grandmother were compound heterozygous for, and each expressing a different combination of, previously reported SLC12A3variants in GS patients. The mother and the maternal grandmother had no symptoms related to GS, and blood gas tests showed that the blood potassium levels and venous pH were within normal limits; however, the venous blood HCO3- levels were slightly elevated. The phenotypic effect of missense mutations is difficult to evaluate, and accumulation of genotypic data with accurate phenotyping, including those of “healthy” and “asymptomatic” individuals in various ethnic populations, will improve the genetic diagnosis of GS.
Erythropoietin Treatment Is Associated with Decreased Blood Glucose Levels in Hematologic Patients
Authors: Oster Howard S. , Gvili Perelman Moran , Kolomansky Albert , Neumann Drorit , Mittelman Moshe
Published: July 2020

Background: Erythroid stimulating agents (ESAs) have pleiotropic effects, and in animal and human studies those exposed to high erythropoietin had lower blood glucose. Objective: To determine the association between ESA and glucose in anemia-treated patients with myelodysplastic syndromes (MDS) or multiple myeloma (MM). Patients and Methods: Patients’ glucose levels were compared while on to while off ESA, and all served as their own controls. To test the association between ESA and blood glucose, we employed a linear mixed model, accounting for variability in the number of measurements for each patient. Results: Charts of 20 patients were reviewed. Mean age was 77 ± 9.8 years (range 50–91). Thirteen patients had MDS, and 8 had MM (1 with both). Glucose (mean ± standard error of the mean) was 116.38 ± 5.21 mg/dL without ESA, as opposed to 105.64 ± 5.11 mg/dL with ESA (p < 0.0001). The 3 diabetic and 5 steroid-treated patients also demonstrated reduced glucose by approximately 19 mg/dL with ESA (p = 0.003 and p = 0.0001, respectively). There was no difference in collective hemoglobin levels between the 2 groups. Conclusion: ESA treatment for anemia is associated with lower blood glucose in hematologic patients. In those who also have diabetes mellitus, ESA might contribute to glucose control, and even to hypoglycemia. Glucose monitoring is thus advised. Further studies with both diabetic and nondiabetic patients are needed to clarify this association and underlying mechanisms.
Teprotumumab Treatment for Thyroid-Associated Ophthalmopathy
Authors: Smith Terry J.
Published: July 2020

Background: Thyroid-associated ophthalmopathy (TAO), an autoimmune process affecting the tissues surrounding the eye, most commonly develops in individuals with Graves’ disease. It is disfiguring, can cause vision loss, and dramatically lessens the quality of life in patients. There has been an absence of approved medical therapies for TAO with proven effectiveness and safety in multicenter, placebo-controlled, and adequately powered clinical trials. Summary: The following is a brief overview of the rationale for developing a monoclonal antibody inhibitor of the insulin-like growth factor-I receptor into a treatment for TAO. This area of fundamental research has yielded an effective and safe medication, namely teprotumumab, based on two multicenter, placebo-controlled trials. Teprotumumab, marketed as Tepezza, has been approved recently by the US Food and Drug Administration for the treatment of TAO. Given its remarkable effectiveness, Tepezza is poised to become the first-line standard of care for TAO. Key Messages: Introduction of Tepezza into our armamentarium of therapeutic strategies for TAO represents a paradigm shift in the management of the disease. I proffer that the drug will replace glucocorticoids as a first-line treatment for TAO.
The Nasoseptal Chondromucosal Flap: A Rigid Reconstructive Technique for Skull Base and Orbital Defects
Authors: Spielman Daniel B. , Kim Matthew , Overdevest Jonathan , Gudis David A.
Published: July 2020

Introduction: The pedicled mucoperichondrial nasoseptal flap serves as the predominant reconstructive option for anterior skull base defects. Its use has also been described for repair of the lamina papyracea following orbital tumor removal. Large skull base or orbital defects may benefit from a more rigid reconstruction to reduce the risk of herniation of orbital or intracranial contents into the sinonasal cavity, which could result in enophthalmos, diplopia, or an encephalocele. Objective: This study aims to test the feasibility of using a vascularized rigid composite nasoseptal chondromucosal flap for increased structural support in repairing skull base or orbital defects. Methods: The study was conducted in a cadaver model in a surgical skills laboratory. Results: We demonstrate a novel technique for harvesting and insetting a pedicled vascularized autologous rigid composite nasoseptal chondromucosal flap to repair both orbital and anterior skull base defects. The graft is harvested with intact mucosa, cartilage, and bilateral perichondrium to preserve a contiguous vascular supply. Confirmation of successful reconstruction is achieved via transcranial and transorbital access to visualize the graft from above. Conclusion: The cartilaginous support with associated perichondrium adds to the structural integrity of the reconstruction and may serve as an alternative to devascularized autologous grafts or synthetic materials, which may be particularly advantageous in patients with large defects or those requiring adjuvant radiation.
Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy
Authors: Fominskiy Evgeny V. , Scandroglio Anna Mara , Monti Giacomo , Calabrò Maria Grazia , Landoni Giovanni , Dell’Acqua Antonio , Beretta Luigi , Moizo Elena , Ravizza Alfredo , Monaco Fabrizio , Campochiaro Corrado , Pieri Marina , Azzolini Maria Luisa , Borghi Giovanni , Crivellari Martina , Conte Caterina , Mattioli Cristina , Silvani Paolo , Mucci Milena , Turi Stefano , Tentori Stefano , Baiardo Redaelli Martina , Sartorelli Marianna , Angelillo Piera , Belletti Alessandro , Nardelli Pasquale , Nisi Francesco Giuseppe , Valsecchi Gabriele , Barberio Cristina , Ciceri Fabio , Serpa Neto Ary , Dagna Lorenzo , Bellomo Rinaldo , Zangrillo Alberto ,   for the COVID-BioB Study Group
Published: July 2020

Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
Fetal Cardiac Remodeling Is Affected by the Type of Embryo Transfer in Pregnancies Conceived by in vitro Fertilization: A Prospective Cohort Study
Authors: Rizzo Giuseppe , Pietrolucci Maria Elena , Mappa Ilenia , Bitsadze Victoria , Khizroeva Jamilya , Makatsariya Alexander , D’Antonio Francesco
Published: July 2020

Objective: Pregnancies conceived via intracytoplasmic sperm injection (ICSI) are associated with a higher risk of fetal cardiac remodeling. The aim of this study was to evaluate whether the type of embryo transfer may affect the magnitude of fetal cardiac remodeling in pregnancies conceived via ICSI. Methods: Prospective cross-sectional study including 212 pregnancies conceived by ICSI (111 with frozen and 101 with fresh embryos) and 120 spontaneously conceived gestations. All women underwent ultrasound biometric evaluation, Doppler, and echocardiographic assessment, including evaluation of left and right atrial areas and sphericity index (SI), at 20–24 weeks of gestation. The χ2 and Kruskal-Wallis H tests were used to analyze the data. Results: There was no difference in maternal characteristics, gestational age at ultrasound, Doppler, and fetal weight among the study groups. In pregnancies conceived by ICSI, left and right atrial areas were higher (p < 0.0001) and SI was lower (p < 0.0001) compared to spontaneously conceived pregnancies. Left (p = 0.004) and right (p = 0.023) atrial areas and left (p = 0.036) and right (p = 0.002) SIs were more affected in ICSI pregnancies conceived by fresh embryos. Conclusion: The risk of fetal cardiac remodeling is higher in pregnancies conceived by ICSI and independent from fetal size and Doppler. The magnitude of these changes is affected by the type of ICSI technique and is higher in pregnancies conceived by fresh embryos.
A implementação do regulamento n° 7 de educação física no Brasil
Authors: Queiroz Kauê Fabiano da Silva , Cancella Karina
Published: July 2020

Apresenta-se um estudo histórico sobre a constituição de uma obra publicada no Brasil na década de 1930 como guia oficial de treinamento dos corpos de tropa: o Regulamento Nº 7 de Educação Física – Método Francês. Ao destacar esta obra como objeto de estudo, tem-se por objetivo empreender análises históricas sobre o processo de implementação do Regulamento Nº 7, apontando os seus principais pressupostos metodológicos a fim de desvelar as bases sobre as quais foi constituído no contexto brasileiro. Ao mesmo tempo, o trabalho procurou compreendê-lo a partir dos interesses políticos e comerciais que o ressignificaram durante o período abordado. O corpus documental selecionado para a pesquisa é composto pelo Regulamento Nº 7 de Educação Física e sua versão original em francês – Règlement Général d’Éducation Physique –, e também por fontes complementares, analisados segundo os seguintes critérios: organização e seleção do material a ser observado, descrição aprofundada do corpus das fontes, busca do referencial teórico e interpretação do material para desvendar os conteúdos mais expressivos. A título de conclusão, destaca-se que a implementação dessa obra no Brasil foi fundamentada sobre um discurso nacionalista, inspirado em modelos europeus de civilidade e modernidade, e com o objetivo de unificar o método de educação física no país.
Formação inicial e atuação profissional em Educação Física
Authors: Ehrenberg Mônica Caldas , Fernandes Rita de Cassia
Published: July 2020

Este trabalho de natureza descritiva investigou as interfaces dos conhecimentos da dança na formação inicial e na atuação profissional em Educação Física em cursos de Licenciatura do Estado de São Paulo. Participaram da pesquisa vinte professores atuantes da área. Foram utilizados o questionário e a análise documental dos programas das disciplinas relacionadas a dança de quatro Instituições de Ensino Superior aos quais os sujeitos foram submetidos em suas formações iniciais. Os dados foram tratados por meio da Análise de Conteúdo e os resultados indicaram os conhecimentos necessários à atuação profissional, possibilitando a tessitura de algumas relações entre a formação e a atuação profissional. Destacamos ser necessário apresentar com clareza os processos metodológicos e avaliativos que envolvem a dança, as vivências criativas, a contextualização dos significados históricos, culturais e sociais que a permeiam, elementos fundamentais na formação de futuros professores de Educação Física.
O papel da Olimpíada Escolar na formação de atletas brasileiros
Authors: Arantes André Almeida Cunha , Martins Francisco , Sarmento Pedro , Melo Gislane Ferreira de
Published: July 2020

O objetivo deste estudo foi analisar o papel da Olimpíada Escolar (OE) no processo de descoberta e desenvolvimento de talentos esportivos no cenário esportivo nacional. A amostra foi constituída pelos atletas escolares medalhistas do sexo masculino e feminino, em seis modalidades, faixa etária de 12 a 14 anos entre os anos 2005 e 2010. Criaram-se critérios de seleção que possibilitaram a aferição do nível técnico da amostra. Confrontando a amostra com os critérios propostos, chegou-se à identificação de 46,3% talentos esportivos no período estudado. A pesquisa identificou que de 2005 a 2010 existiu um aumento significativo de 53,7% na taxa de identificação dos talentos esportivos. Em relação ao percentual de identificação por sexo, o feminino foi maior do que o masculino. Em função da crescente identificação de talentos, pode-se concluir que a Olimpíada Escolar tem cumprido papel relevante no processo de descoberta e desenvolvimento de talentos esportivos no Brasil.
Como entender o descolonial? Releitura de Ch’ixinakax utxiwa. Una reflexión sobre prácticas y discursos descolonizadores
Authors: Demarchi Villalón Corina , Sanabria-González Iván David
Published: July 2020

Em Ch’ixinakax utxiwa. Una reflexión sobre prácticas y discursos descolonizadores (Tinta Limón, Buenos Aires, 2010), Silvia Rivera Cusicanqui (La Paz, Bolívia, 1949), realiza uma análise crítica descolonizadora do social a partir de noções e conceitos do mundo andino. O livro é organizado em três partes ou capítulos, El otro bicentenario; Sociología de la Imagen. Una visión desde la historia colonial andina; e Ch´ixinakax utxiwa. Una reflexión sobre prácticas y discursos descolonizadores. A análise crítica que propõe a autora, parte da compreensão e reivindicação da concepção indígena do mundo. O livro assume como noção central o ch’ixi, conceito aymara que é a base para o desenvolvimento das críticas e propostas de descolonização. Estas se revelam em, ao menos, dois caminhos. Por um lado, as críticas aos modos ocidentais de construção da história andina e, por outro, as estratégias do discurso multicultural.
A Fundação de Apoio e Mobilização Social (FAMFS), o esporte e a inclusão social
Authors: Rossi Junior Renildo , Pereira Antonino , Alencar Roselene de , Rossi Mariana Santiago , Azevêdo Paulo Henrique
Published: July 2020

O entendimento de que o esporte favorece a inclusão social, pode ser visto em um grande número de projetos esportivos. Apesar disso, este constitui um fenômeno multifacetado e complexo, que carece de ser compreendido na sua contribuição real ou potencial para os processos de desenvolvimento da humanidade. Ante ao exposto, a presente investigação objetivou analisar e discutir os contributos da Fundação de Apoio ao Cidadão e Mobilização Social (FAMFS), para a inclusão social no município de Feira de Santana, Estado da Bahia – Brasil, com ações relacionadas do esporte. O presente artigo justifica-se, ante a necessidade de estudos de impacto de projetos sociais nas comunidades, a partir da implementação de atividades esportivas. Para tanto, recorremos ao método qualitativo, de base etnográfica. As fontes de coleta de dados utilizadas foram entrevistas, documentos (base institucional, impressa e eletrônica), e notas de campo provenientes das atividades de observação-participante. A maioria dos resultados aponta que o projeto mais evidenciado envolveu a fabricação de materiais esportivos,através dos Programas “Pintando a Liberdade e Cidadania”, beneficiando as crianças, os adolescentes, mas também as suas famílias. O principal parceiro da FAMFS, na dinamização dos vários projetos esportivos sociais foi o poder público. As estratégias utilizadas pela fundação para cooperação e diálogo intersetorial na dinamização dos seus projetos esportivos sociais, envolveu a formalização de convênios com o poderpúblico, nos três níveis (municipal, estadual e federal). Em síntese, os dados evidenciam que as ações da FAMFS beneficiaram a inclusão social de crianças e adolescentes, e as suas famílias, com ações relacionadas ao esporte. Esta intervenção foi amplamente reconhecida e valorizada pelas autoridades públicas brasileiras e por diversas instituições nacionais e internacionais.
¿Qué piensa el alumnado sobre sus profesores de educación física?
Authors: Gaviria Cortes Didier Fernando , Castejón Oliva Francisco Javier
Published: July 2020

La investigación sobre el pensamiento del alumno que se presenta en este trabajo, se basa en que el estudiante juega un papel activo y fundamental en su propio proceso de aprendizaje. Este tipo de investigación deduce que lo que los estudiantes crean, piensen y sientan, puede afectar la forma de entender los contenidos que se enseñan y el valor que ellos pueden tener para sus vidas, el gusto por la asignatura y su aprendizaje. En este sentido, el objetivo fue interpretar y analizar las creencias y percepciones que tienen los estudiantes acerca de sus profesores de educación física. La investigación fue cualitativa. El diseño es un estudio de caso donde se ha utilizado cuestionario, grupos focales y observación como estrategias de recolección de información. El estudio se realizó en una institución educativa de Medellín-Colombia. Participaron tres docentes y 103 estudiantes de último grado de educación secundaria. Como conclusión, los estudiantes creen que un buenprofesor es aquel que los respeta y trata a todos por igual, sin hacer discriminación alguna, explica bien para qué sirven los contenidos y actividades, cuáles son sus objetivos, es justo en las pruebas y cuando evalúa. Los estudiantes tienen una imagen de los profesores entre dos direcciones: a) el profesor como amigo y guía que aporta elementos positivos para su formación; b) el profesor poco exigente, sin autoridad y falto de liderazgo.
Lesões faciais e protetores bucais na prática desportiva
Authors: Martins Yuri Victor de Medeiros , Lima Isabela Pinheiro Cavalcanti , Santos Marquiony Marques dos
Published: July 2020

São muitos os acidentes esportivos que resultam em traumas faciais. O uso dos protetores bucais torna-se imprescindível como medida de proteção dos atletas. O objetivo do estudo foi quantificar e qualificar as lesões orofaciais decorrentes da prática desportiva, assim como traçar um paralelo com o uso dos protetores bucais. Para tanto realizou-se um estudo transversal e descritivo compreendendo 248 praticantes de oitomodalidades esportivas distintas da Paraíba e do Rio Grande do Norte. A investigação contou com a aplicação de um questionário já validado na literatura. Os dados obtidos receberam um tratamento estatístico pelo Teste Exato de Fisher (p < 0,05) bem como foram analisados por meio de estatística descritiva, o programa responsável foi o SPSS 20.0. Cerca de 80% dos indivíduos já sofreram um trauma facial durante sua vidaesportiva, com a lesão de tecido mole e a fratura dental como mais comum. A quase totalidade dos indivíduos (92,7%) afirmou conhecer os protetores bucais. 223 esportistas (89,9%) já usaram o protetor bucal em algum momento de sua vida esportiva, porém apenas 50% relataram o uso rotineiro. Já em relação ao tipo de protetor bucal utilizado, esta pesquisa trás o tipo termoplástico com 71,4% do total (n = 177). As lesõesorofaciais fazem parte da rotina dos atletas. No entanto, as pessoas envolvidas no meio esportivo como um todo ainda não prestam a devida importância ao tema. Sendo assim, recomenda-se o surgimento de políticas de regularização do uso do protetor bucal nos esportes e também a divulgação dos benefícios que a proteção e a prevenção trazem aos atletas.
O tipo de polimento altera a força explosiva de membros inferiores em atletas de voleibol?
Authors: Fortes Leonardo de Sousa De Sousa , Lira Hugo Augusto Alvares da Silva , Oliveira Geraldo José Santos , Vianna Jeferson Macedo , Santos Tony Meireles dos
Published: July 2020

O objetivo foi analisar o efeito do tipo de polimento na força explosiva de membros inferiores (FEMI) em jovens atletas de voleibol. Participaram 42 atletas com idade entre 15 e 17 anos, divididos aleatoriamente em 3 grupos: linear (GL), por etapa (GE) e controle (GC). Todos os grupos fizeram a mesma planificação de treinamento até a fase do polimento. Somente o GC não realizou polimento. O polimento teve duração de 3semanas, adotando-se o método de polimento linear para o GL e polimento por etapa para o GE. Utilizou-se a plataforma de força para avaliar a FEMI. Este instrumento foi utilizado antes do início da temporada e na última semana de cada mesociclo. Conduziu-se a análise univariada de covariância (ANCOVA) de medidas repetidas para comparar a FEMI entre os grupos em função do mesociclo. Os resultados apresentaram efeitosde tempo (F(4, 38) = 31,93, p = 0,01) e grupo (F(3, 39) = 41,87, p = 0,01). A FEMI aumentou no GL (F(2, 13) = 32,55, p = 0,01) e GE (F(2, 12) = 29,14, p = 0,01) após o polimento, fato não revelado para o GC (F(2, 11) = 3,48, p = 0,19). De maneira geral, os achados do presente estudo revelaram o aumento da FEMI após o polimento para GL e GE. Concluiu-se que o polimento foi eficaz para melhorar a FEMI de atletas de voleibol.
Efeitos da oclusão temporal na geração de opções na tomada de decisão de atletas e não atletas de voleibol
Authors: Castro Henrique De Oliveira , Costa Gustavo De Conti Teixeira , Praça Gibson Moreira , Pires Flávio De Oliveira , Greco Pablo Juan
Published: July 2020

Objetiva-se investigar o efeito da oclusão temporal na quantidade de opções geradas no momento da tomada de decisão (TD) de atletas e não atletas de voleibol. Participaram 46 voluntários, sendo 23 atletas e 23 não atletas. Para análise da quantidade de opções geradas no momento da TD, utilizou-se o Teste de Conhecimento Tático Declarativo no Voleibol (TCTD:Vb) realizado em duas situações: com e sem oclusão temporal. Quando comparados os dois grupos na situação com oclusão, observa-se que os atletas geraram mais opções do que os não atletas. Quando comparadas as duas situações, geraram-se mais opções na situação sem oclusão do que na com oclusão nos dois grupos. Conclui-se que a quantidade de opções geradas depende das estratégias utilizadas para a resolução de uma ação e do tempo disponível para visualizar determinada situação de jogo.