bluuebunny/crossref_metadata_2025 huggingface dataset:
Les séries télévisées, un art de l’espace ?
Authors: Monnet-Cantagrel Hélène
Published: November 2023

Cet article se propose de montrer comment la question de l’espace est si fondatrice pour les séries qu’elle amène à envisager le développement d’une géopoétique ou d’une géocritique qui permettrait d’en saisir les enjeux. L’espace – ou le lieu – est, dans les séries, une structure profonde autour de laquelle s’organise la sémiotisation et la narration de la fiction. C’est là une spécificité de fonctionnement propre à la sérialité comprise autant dans sa dimension narratologique qu’institutionnelle. L’espace sériel se construit, en effet, en corrélation avec celui, intra-mondain, des publics auxquels il propose une image de l’être-au-monde, confirmant ainsi que l’espace pourrait être un paradigme d’analyse des séries fictionnelles.
La « télé-réalité » par ses formes sonores : de la mutation d’un format télévisuel à son extension vers les réseaux socio-numériques (2001-2022)
Authors: Guéraud-Pinet Guylaine
Published: November 2023

Depuis la fin des années 2000, la télé-réalité investit les réseaux socio-numériques (RSN). Que cela soit sur les comptes des instances de production et de diffusion des programmes ou encore sur ceux de ses participants, des contenus audiovisuels y sont disséminés. Ces derniers reposent sur une forme audio-scripto-visuelle mêlant le son, l’image, le texte et diverses iconographies. Cet article s’intéresse à la manière dont ces contenus semblent hériter de formes d’ores et déjà mobilisées à la télévision. Il s’intéresse particulièrement aux formes sonores de la télé-réalité. Par conséquent, à partir d’une analyse statistique des contenus appliquée à un corpus d’émissions de télé-réalité (18) et de publications audiovisuelles (353) sur Instagram, il montre les mutations de ce format depuis la première édition de Loft Story , en 2001, et son extension promotionnelle sur les RSN et enfin, son adaptation aux écritures numériques.
Fonctionnement textuel des syntagmes nominaux démonstratifs appositifs
Authors: Tritar-Ben Ahmed Saloua
Published: November 2023

La présente contribution se propose de focaliser l’intérêt sur la catégorie des syntagmes nominaux appositifs comportant des déterminants démonstratifs en les inscrivant dans une double opposition : celle, d’une part, entre les syntagmes nominaux démonstratifs appositifs spécifiques et les génériques, et celle, d’autre part, entre les syntagmes nominaux démonstratifs appositifs mémoriels spécifiques et leurs pendants génériques. Cette double opposition relative au fonctionnement des syntagmes nominaux démonstratifs appositifs est saisie dans un cadre textuel, en l’occurrence l’œuvre romanesque d’H. de Balzac, Le Lys dans la vallée , et se focalise sur leur rôle énonciatif dans le discours en tant que foyer du point de vue – au sens narratologique et axiologique du terme – à travers l’analyse de leurs cotextes et de leurs supports.
Corneal Higher Order Aberrations and Epithelial Remodeling With Femtosecond Laser–Assisted LASIK Topography-guided and Customized Asphericity Ablation in the Contralateral Eye: A Randomized, Double-Blind, Prospective Study
Authors: Lyra Adriana F.V. , Alves Ermano M. , Montenegro Afra A. , Parente Natália S. , Cardoso Manuela T. , Alves Lucas M. , Maia Carolina B. , Fontes Bruno M. , Nose Walton
Published: November 2023

Purpose:

To evaluate refractive results, corneal higher order aberrations (HOAs), and epithelial remodeling in the preoperative and postoperative period of regular corneas that had topography-guided femtosecond laser–assisted laser in situ keratomileusis (LASIK) (Contoura WaveLight; Alcon Laboratories, Inc) and compare them with the contralateral eye that underwent ablation customized by asphericity (Custom-Q WaveLight; Alcon Laboratories, Inc) in myopic eyes with or without astigmatism.

Methods:

A prospective, randomized, and double-blind study was conducted. Patients underwent preoperative and postoperative epithelial mapping and corneal tomography to assess the epithelial thickness map, HOAs of the corneal anterior surface, visual acuity, and refractive evaluation.

Results:

This study enrolled 96 normal eyes of 48 patients. Uncorrected distance visual acuity of 20/20 or better was achieved in 97% of patients and gains in corrected distance visual acuity and effectiveness in correcting refractive astigmatism were similar in both techniques. Seventeen sectors of the corneal epithelium map were assessed by spectral-domain optical coherence tomography and no significant differences were found between techniques preoperatively and postoperatively (
P
> .05). HOA root mean square, coma Z
3
±1
, trefoil Z
3
−
3
, and tissue consumption exhibited statistically significant between-technique differences (
P
< .05).

Conclusions:

The Contoura and Custom-Q techniques were similar with respect to refractive and visual outcomes after 3 months, as well as in epithelial remodeling. The Contoura provides lower postoperative HOA root mean square, coma Z
3
±1
, and trefoil Z
3
−
3
values, but the techniques showed no differences in the correction of the corneal astigmatic wavefront component and in the spherical aberration after 3 months.

[
J Refract Surg
. 2023;39(11):751–758.]
Encouraging Parental Reflective Functioning in Caring for the Adolescent Patient: Opportunities to Foster Connection
Authors: Cama Shireen , Peleggi Analise
Published: November 2023

Parental reflective functioning is the capacity for parents to understand how their actions and those of their children are affected by both their thoughts and emotions. Strong reflective functioning skills can be especially helpful for families of adolescents, to build understanding and connection during a time of great developmental change. This article offers pediatricians ways that they can encourage and strengthen parental reflective functioning while providing anticipatory guidance and supporting families through times of conflict or stress.

[
Pediatr Ann
. 2023;52(11):e409–e412.]
Universal and Trauma-Specific Care Suggestions for Pediatric Primary Care Settings
Authors: Vesco Anthony T. , Lerner Megan K. , Burnside Amanda N.
Published: November 2023

Trauma exposure and other adverse life events are common experiences among youth and present long-standing mental and physical health consequences. Given the ongoing lack of sufficient mental health services, pediatricians play a critical role in supporting trauma-exposed youth. We propose both universal precaution and trauma-specific strategies for pediatric primary care settings. Universal interventions include recommendations to make health care systems more trauma-informed, reduce trauma or re-traumatization in the medical setting, eliminate potential bias, and focus on a strengths-based approach to support diverse youth and families. Trauma-specific strategies include screening for trauma-related symptomatology and risk stratification to link youth to appropriate levels of care. Specific assessment tools, resources, and materials are provided.

[
Pediatr Ann
. 2023;52(11):e418–e421.]
Conformal bi-slant submersion from Kenmotsu manifolds
Authors: Al-Dayel Ibrahim , Shuaib Mohammad
Published: November 2023

The prospect of conformal bi-slant submersions from a Kenmotsu manifold is discussed in the present article, taking into account that the Reeb vector field $ \xi $ is vertical. We looked at the integrability of distributions as well as the geometry of distribution leaves since the concept of bi-slant submersion ensures the presence of slant distributions. Finally, the idea of pluriharmonicity is also described in the paper, along with a supporting example for our research.
Application of Multimedia Data Feature Extraction Technology in Teaching Classical Oil Painting
Authors: Chen Zhuo , Li Jianmiao
Published: November 2023

The cross-modal oil painting image generated by traditional methods makes it easy to miss the important information of the target part, and the generated image lacks realism. This paper combines the feature extraction technology of multimedia data with the generation confrontation network in deep learning, puts forward a generation model of classic oil painting, and applies it to university teaching. Firstly, the key frame extraction algorithm is used to extract the key frames in the video, and the channel attention network is introduced into the pre-trained ResNet-50 network to extract the static features of 2D images in short oil painting videos. Then, the depth feature mapping is carried out in the time dimension by using the double-stream I3D network, and the feature representation is enhanced by combining static and dynamic features. Finally, the high-dimensional features in the depth space are mapped to the two-dimensional space by using the opposition generation network to generate classic oil painting pictures.
Application of a Network Teaching Platform in English Classroom Teaching
Authors: Zhang Linfeng
Published: November 2023

The online teaching platform based on the online teaching system on the internet has been widely used in the English education industry. Language education researchers, English teachers, and educational technology professionals are interested in exploring the potential of online teaching platforms in language education. This article explores the impact of the teaching platform based on MOOC on English classroom teaching. By comparing the teaching effects of using MOOC teaching platform and traditional teaching methods, this article analyzes the impact of online teaching platform on English classroom teaching and provides theoretical data support to promote the application of online teaching platform in English classroom teaching. The research results show that compared with traditional teaching methods, the flipped classroom teaching model using the MOOC teaching platform achieves optimization of the learning process and teaching effectiveness and improves attitudes, interests, strategies, and cooperation in English learning.
The Impact of Dissonant Tie on Innovation Performance of Digital Transformation
Authors: Xiao Yao , Chen Ye , Tan Jinghua , Cifuentes-Faura Javier
Published: November 2023

The acquisition of innovation performance through social network relationship resources is a common behavior pattern of organizational members. Recent social network research suggests that negative ties may also have a positive impact on organizational innovation compared with positive ties. Based on this, the paper investigates the impact of dissonant tie, which are a combination of problem-solving tie and difficult working tie, on organizational innovation. The empirical results show that dissonant tie promotes organizational innovation performance and are enhanced by digital sensing and digital seizing, while the increasing effect of the dissonant tie on organizational innovation performance is not verified under the moderating effect of digital reconfiguring. The findings are useful for understanding why certain negative ties may promote organizational innovation and performance, and to provide a theoretical basis for how manufacturing companies can use complex social network ties to survive organizational change and enhance organizational adaptability in digital transformation.
Enhancing Supply Chain Transparency and Risk Management Using CNN-LSTM With Transfer Learning
Authors: Zhang Yongping , Shankar Achyut
Published: November 2023

Enhancing supply chain transparency and risk management is crucial in modern businesses. The supply chain involves multiple stages and participants, including suppliers, manufacturers, and logistics companies. However, supply chain data is often vast and complex, encompassing various types of information. Effectively analyzing and leveraging this data can help businesses identify potential risks and improvement opportunities. Therefore, a powerful method is needed to process supply chain data and provide accurate predictions and decision support. In this article, the authors approach is based on CNN-LSTM and transfer learning. By comparing with traditional methods and baseline models, this CNN-LSTM model achieved significant improvements in supply chain transparency and risk management. This model accurately predicts potential supply chain risks, providing corresponding decision support. This research is of great significance to enhance the efficiency, reliability, and transparency of the supply chain, offering valuable support for business decision-making.
Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury
Authors: Dou Yanan , Fei Xiaowei , He Xin , Huan Yu , Wei Jialiang , Wu Xiuquan , Lyu Weihao , Fei Zhou , Li Xia , Fei Fei
Published: November 2023

JOURNAL/nrgr/04.03/01300535-202407000-00042/figure1/v/2023-11-20T171125Z/r/image-tiff

Elevated intraocular pressure (IOP) is one of the causes of retinal ischemia/reperfusion injury, which results in NLRP3 inflammasome activation and leads to visual damage. Homer1a is reported to play a protective role in neuroinflammation in the cerebrum. However, the effects of Homer1a on NLRP3 inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain unknown. In our study, animal models were constructed using C57BL/6J and Homer1flox/
–/Homer1a+/
–/Nestin-Cre+/
– mice with elevated IOP-induced retinal ischemia/reperfusion injury. For in vitro experiments, the oxygen-glucose deprivation/reperfusion injury model was constructed with Müller cells. We found that Homer1a overexpression ameliorated the decreases in retinal thickness and Müller cell viability after ischemia/reperfusion injury. Furthermore, Homer1a knockdown promoted NF-κB P65Ser536 activation via caspase-8, NF-κB P65 nuclear translocation, NLRP3 inflammasome formation, and the production and processing of interleukin-1β and interleukin-18. The opposite results were observed with Homer1a overexpression. Finally, the combined administration of Homer1a protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1flox/
–/Homer1a+/
–/Nestin-Cre+/
– mice and apoptosis in Müller cells after ischemia/reperfusion injury. Taken together, these studies demonstrate that Homer1a exerts protective effects on retinal tissue and Müller cells via the caspase-8/NF-κB P65/NLRP3 pathway after I/R injury.
Lactate: a prospective target for therapeutic intervention in psychiatric disease
Authors: Cai Yanhui , Guo Haiyun , Han Tianle , Wang Huaning
Published: November 2023

Although antipsychotics that act via monoaminergic neurotransmitter modulation have considerable therapeutic effect, they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorders. This may be attributed to the limited range of neurotransmitters that are regulated by psychotropic drugs. Recent findings indicate the need for investigation of psychotropic medications that target less-studied neurotransmitters. Among these candidate neurotransmitters, lactate is developing from being a waste metabolite to a glial-neuronal signaling molecule in recent years. Previous studies have suggested that cerebral lactate levels change considerably in numerous psychiatric illnesses; animal experiments have also shown that the supply of exogenous lactate exerts an antidepressant effect. In this review, we have described how medications targeting newer neurotransmitters offer promise in psychiatric diseases; we have also summarized the advances in the use of lactate (and its corresponding signaling pathways) as a signaling molecule. In addition, we have described the alterations in brain lactate levels in depression, anxiety, bipolar disorder, and schizophrenia and have indicated the challenges that need to be overcome before brain lactate can be used as a therapeutic target in psychopharmacology.
Functional near-infrared spectroscopy in non-invasive neuromodulation
Authors: Huo Congcong , Xu Gongcheng , Xie Hui , Chen Tiandi , Shao Guangjian , Wang Jue , Li Wenhao , Wang Daifa , Li Zengyong
Published: November 2023

Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks, which have been widely applied in the field of central neurological diseases, such as stroke, Parkinson's disease, and mental disorders. Although significant advances have been made in neuromodulation technologies, the identification of optimal neurostimulation parameters including the cortical target, duration, and inhibition or excitation pattern is still limited due to the lack of guidance for neural circuits. Moreover, the neural mechanism underlying neuromodulation for improved behavioral performance remains poorly understood. Recently, advancements in neuroimaging have provided insight into neuromodulation techniques. Functional near-infrared spectroscopy, as a novel non-invasive optical brain imaging method, can detect brain activity by measuring cerebral hemodynamics with the advantages of portability, high motion tolerance, and anti-electromagnetic interference. Coupling functional near-infrared spectroscopy with neuromodulation technologies offers an opportunity to monitor the cortical response, provide real-time feedback, and establish a closed-loop strategy integrating evaluation, feedback, and intervention for neurostimulation, which provides a theoretical basis for development of individualized precise neurorehabilitation. We aimed to summarize the advantages of functional near-infrared spectroscopy and provide an overview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation, transcranial electrical stimulation, neurofeedback, and brain-computer interfaces. Furthermore, the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are summarized. In conclusion, functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central neural reorganization to achieve better functional recovery from central nervous system diseases.
A “messenger zone hypothesis” based on the visual three-dimensional spatial distribution of motoneurons innervating deep limb muscles
Authors: Huang Chen , Wang Shen , Deng Jin , Gu Xinyi , Guo Shuhang , Yin Xiaofeng
Published: November 2023

JOURNAL/nrgr/04.03/01300535-202407000-00036/figure1/v/2023-11-20T171125Z/r/image-tiff

Coordinated contraction of skeletal muscles relies on selective connections between the muscles and multiple classes of the spinal motoneurons. However, current research on the spatial location of the spinal motoneurons innervating different muscles is limited. In this study, we investigated the spatial distribution and relative position of different motoneurons that control the deep muscles of the mouse hindlimbs, which were innervated by the obturator nerve, femoral nerve, inferior gluteal nerve, deep peroneal nerve, and tibial nerve. Locations were visualized by combining a multiplex retrograde tracking technique compatible with three-dimensional imaging of solvent-cleared organs (3DISCO) and 3-D imaging technology based on lightsheet fluorescence microscopy (LSFM). Additionally, we propose the hypothesis that “messenger zones” exist as interlaced areas between the motoneuron pools that dominate the synergistic or antagonist muscle groups. We hypothesize that these interlaced neurons may participate in muscle coordination as messenger neurons. Analysis revealed the precise mutual positional relationships among the many motoneurons that innervate different deep muscles of the mouse. Not only do these findings update and supplement our knowledge regarding the overall spatial layout of spinal motoneurons that control mouse limb muscles, but they also provide insights into the mechanisms through which muscle activity is coordinated and the architecture of motor circuits.
Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1
Authors: Gu Qi , Sha Weiping , Huang Qun , Wang Jin , Zhu Yi , Xu Tianli , Xu Zhenhua , Zhu Qiancheng , Ge Jianfei , Tian Shoujin , Lin Xiaolong
Published: November 2023

JOURNAL/nrgr/04.03/01300535-202407000-00037/figure1/v/2023-11-20T171125Z/r/image-tiff

Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury. Fibroblast growth factor 21 can inhibit ferroptosis and promote neurofunctional recovery, while heme oxygenase-1 is a regulator of iron and reactive oxygen species homeostasis. The relationship between heme oxygenase-1 and ferroptosis remains controversial. In this study, we used a spinal cord injury rat model to show that the levels of fibroblast growth factor 21 in spinal cord tissue decreased after spinal cord injury. In addition, there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord injury. Further, heme oxygenase-1 aggravated ferroptosis after spinal cord injury, while fibroblast growth factor 21 inhibited ferroptosis by downregulating heme oxygenase-1. Thus, the activation of fibroblast growth factor 21 may provide a potential treatment for spinal cord injury. These findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.
High-frequency repetitive transcranial magnetic stimulation promotes neural stem cell proliferation after ischemic stroke
Authors: Luo Jing , Feng Yuan , Hong Zhongqiu , Yin Mingyu , Zheng Haiqing , Zhang Liying , Hu Xiquan
Published: November 2023

JOURNAL/nrgr/04.03/01300535-202408000-00031/figure1/v/2024-02-22T141052Z/r/image-tiff

Proliferation of neural stem cells is crucial for promoting neuronal regeneration and repairing cerebral infarction damage. Transcranial magnetic stimulation (TMS) has recently emerged as a tool for inducing endogenous neural stem cell regeneration, but its underlying mechanisms remain unclear. In this study, we found that repetitive TMS effectively promotes the proliferation of oxygen-glucose deprived neural stem cells. Additionally, repetitive TMS reduced the volume of cerebral infarction in a rat model of ischemic stroke caused by middle cerebral artery occlusion, improved rat cognitive function, and promoted the proliferation of neural stem cells in the ischemic penumbra. RNA-sequencing found that repetitive TMS activated the Wnt signaling pathway in the ischemic penumbra of rats with cerebral ischemia. Furthermore, PCR analysis revealed that repetitive TMS promoted AKT phosphorylation, leading to an increase in mRNA levels of cell cycle-related proteins such as Cdk2 and Cdk4. This effect was also associated with activation of the glycogen synthase kinase 3β/β-catenin signaling pathway, which ultimately promotes the proliferation of neural stem cells. Subsequently, we validated the effect of repetitive TMS on AKT phosphorylation. We found that repetitive TMS promoted Ca2+ influx into neural stem cells by activating the P2 calcium channel/calmodulin pathway, thereby promoting AKT phosphorylation and activating the glycogen synthase kinase 3β/β-catenin pathway. These findings indicate that repetitive TMS can promote the proliferation of endogenous neural stem cells through a Ca2+ influx-dependent phosphorylated AKT/glycogen synthase kinase 3β/β-catenin signaling pathway. This study has produced pioneering results on the intrinsic mechanism of repetitive TMS to promote neural function recovery after ischemic stroke. These results provide a strong scientific foundation for the clinical application of repetitive TMS. Moreover, repetitive TMS treatment may not only be an efficient and potential approach to support neurogenesis for further therapeutic applications, but also provide an effective platform for the expansion of neural stem cells.
Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis: a cross-sectional study
Authors: He Lu , Zhou Qinming , Xiu Chaoyang , Shao Yaping , Shen Dingding , Meng Huanyu , Le Weidong , Chen Sheng
Published: November 2023

JOURNAL/nrgr/04.03/01300535-202408000-00039/figure1/v/2024-02-22T141052Z/r/image-tiff

Biomarkers are required for the early detection, prognosis prediction, and monitoring of amyotrophic lateral sclerosis, a progressive disease. Proteomics is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarkers. In this study, we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral sclerosis compared with five healthy controls. Substantial upregulation of serum proteins related to multiple functional clusters was observed in patients with sporadic amyotrophic lateral sclerosis. Potential biomarkers were selected based on functionality and expression specificity. To validate the proteomics profiles, blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent assay. Eight substantially upregulated serum proteins in patients with sporadic amyotrophic lateral sclerosis were selected, of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls (area under the curve [AUC] = 0.713, P < 0.0001). To further enhance diagnostic accuracy, a multi-protein combined discriminant algorithm was developed incorporating five proteins (hemoglobin beta, cathelicidin-related antimicrobial peptide, talin-1, zyxin, and translationally-controlled tumor protein). The algorithm achieved an AUC of 0.811 and a P-value of < 0.0001, resulting in 79% sensitivity and 71% specificity for the diagnosis of sporadic amyotrophic lateral sclerosis. Subsequently, the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls, as well as patients with different disease severities, was examined. A two-protein panel comprising talin-1 and translationally-controlled tumor protein effectively distinguished early-stage amyotrophic lateral sclerosis patients from controls (AUC = 0.766, P < 0.0001). Moreover, the expression of three proteins (FK506 binding protein 1A, cathelicidin-related antimicrobial peptide, and hemoglobin beta-1) was found to increase with disease progression. The proteomic signatures developed in this study may help facilitate early diagnosis and monitor the progression of sporadic amyotrophic lateral sclerosis when used in combination with current clinical-based parameters.
Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression: a randomized controlled study
Authors: Li Xiaoyue , Liu Tao , Mo Xuan , Wang Runhua , Kong Xueyan , Shao Robin , McIntyre Roger S. , So Kwok-Fai , Lin Kangguang
Published: November 2023

JOURNAL/nrgr/04.03/01300535-202409000-00036/figure1/v/2024-01-30T062302Z/r/image-tiff

Strong evidence has accumulated to show a correlation between depression symptoms and inflammatory responses. Moreover, anti-inflammatory treatment has shown partial effectiveness in alleviating depression symptoms. Lycium barbarum polysaccharide (LBP), derived from Goji berries, exhibits notable antioxidative and anti-inflammatory properties. In our recent double-blinded randomized placebo-controlled trial, we found that LBP significantly reduced depressive symptoms in adolescents with subthreshold depression. It is presumed that the antidepressant effect of LBP may be associated with its influence on inflammatory cytokines. In the double-blinded randomized controlled trial, we enrolled 29 adolescents with subthreshold depression and randomly divided them into an LBP group and a placebo group. In the LBP group, adolescents were given 300 mg/d LBP. A 6-week follow up was completed by 24 adolescents, comprising 14 adolescents from the LBP group (15.36 ± 2.06 years, 3 men and 11 women) and 10 adolescents from the placebo group (14.9 ± 1.6 years, 2 men and 8 women). Our results showed that after 6 weeks of treatment, the interleukin-17A level in the LBP group was lower than that in the placebo group. Network analysis showed that LBP reduced the correlations and connectivity between inflammatory factors, which were associated with the improvement in depressive symptoms. These findings suggest that 6-week administration of LBP suppresses the immune response by reducing interleukin-17A level, thereby exerting an antidepressant effect.
Comprehensive review on millets: Nutritional values, effect of food processing and dietary aspects
Authors: Maurya Rahul , Boini Thirupataiah , Misro Lakshminarayana , Radhakrishnan Thulasi , Sreedharan Aswani Pulikunnel , Gaidhani Dhanashree
Published: November 2023

Millets are a group of small-seeded grains cultivated for centuries as staple food crops in many parts of the world. In the recent years, there has been a growing interest in millet due to its exceptional nutritional and health benefits. Millets are rich in essential nutrients such as proteins, dietary fiber, vitamins, minerals, and antioxidants. They are also gluten-free and have a low glycemic index, making them suitable for individuals with gluten intolerance or diabetes. Studies have shown that regular millet consumption can contribute to several health benefits. The high fiber content in millet aids digestion, prevents constipation, and promotes a healthy gut microbiome. Millets reduce the risk of chronic diseases, including cardiovascular diseases, type 2 diabetes, and certain cancers. The antioxidants in millet help to protect against oxidative stress and inflammation, which are underlying factors in various conditions.

Furthermore, millet has a positive impact on weight management. The combination of high fiber and low glycemic index in millets promotes satiety, regulates blood sugar levels, and helps to maintain a healthy body weight. Additionally, millet has anti-inflammatory, antimicrobial, and anticancer properties. In conclusion, millet offers a wide range of nutritional and health benefits. Their nutrient density, gluten-free nature, and low glycemic index make them valuable in a balanced diet. Incorporating millet into regular meals can contribute to improved overall health and well-being. Further research is needed to explore the full potential of millets and their specific health effects on different populations. This review discussed the various involved government bodies and their dietary guidelines. Policy development and dietary guidelines play a crucial role in promoting millet consumption.
A review on the use and scope of finger millet (Ragi) in prevention and management of non-communicable diseases
Authors: Sawant Prajakta Dhairyashil , Tavhare Swagata Dilip
Published: November 2023

Ragi (Eleusine coracana L.), or finger millet, is one of the ancient millets used as a staple food in India. Modernization has created an impact on the food habits of humans. Refined flours, polished grains, newly harvested grains, processed and preservative-added foods are causative factors for lifestyle diseases namely diabetes, hypertension, cardiovascular diseases, obesity, lung disorders, gluten enteropathy, and hormonal imbalances. Good quality nutritional food is essential for maintaining health. The Indian government is endeavoring to introduce traditional food practices to the globe. International Year of Millets 2023 has widely gained the global attention toward millets and their health benefits. Millets are nutri-cereals and are vital part of grains in Indian foods. Ragi is a prime millet crop with nutritional, therapeutic, and commercial importance. Ragi contains high amounts of calcium, and protein with well-balanced essential amino acids. Thus, ragi is an ideal food for diseases such as diabetes, cardiovascular diseases, chronic obstructive pulmonary disease, and cancer. Its high fiber content prevents constipation, high blood pressure, and gluten intolerance. It has demonstrated the ability to control blood glucose levels due to low glycemic index (54–68) and insoluble fibers, which helps to control blood glucose levels in hyperglycemia, making it an essential food for diabetes. It is pesticide-free, easy to grow, and cost-effective crop, hence a choice for commercial gains. The current review presents ragi's significance in preventing and managing non-communicable diseases.
Exploring the common millets of India: A comprehensive review
Authors: Balkrishna Acharya , Shankar Rama , Prajapati Uday Bhan , Joshi Rashmi Atul , Srivastava Anupam , Awasthi Chetan
Published: November 2023

Millets were a part of human diet as well as fodder in the past and was helpful in prevention of many diseases especially lifestyle diseases. Because of the dependence on wheat and rice as major source of food and the rise in use of junk food, millets were neglected from routine diet. The rise in incidence of non-communicable diseases, across the globe has helped generate an awareness to include nutri-cereals in the daily food to address the contemporary of lifestyle. Information pertaining to millets, especially on Indian millets, has been collected from various resources, books, research papers and e-platforms for the researches on millets. Nine types of millets are widely used across India. Millets have been the cornerstone of Indian cuisine since centuries and there is much scope for its revival in the present era.
Policy support for the promotion of millets: Current status and its impact
Authors: Jadhav Narayan , Londhe Deepak J
Published: November 2023

The world is currently experiencing an agrarian crisis, nutritional crisis, and climate change catastrophe, leading to need for sustainable crop substitutes that require less water and have significant nutritional values. Millets are considered “climate savvy” and “Nutri-Cereals” due to their ability to adapt to dynamic climatic conditions and numerous health advantages respectively. They are crucial for maintaining people's health and well-being and can help in preventing disorders connected to modern lifestyles, such as diabetes and obesity. Various Government initiative have been taken to promoter millets. This paper discusses about some of the policies adopted by the Government for the promotion of millet, its impact, and future directions.
Computational screening of foxtail millet (Setaria italica (L.) P.Beauv.) polyphenols for finding β-secretase (BACE 1) inhibitors that target the amyloidogenic pathway in Alzheimer's disease
Authors: Cheemanapalli Srinivasulu , Golla Ramanjaneyulu , Koyyagura Jagadeeswar Reddy , Pulicherla Yugandhar , Bhardwaj Yashpal , Bhuyan Birina , Taboh Mumtam , Nagayya Shiddamallayya , Saddala Rajeswara Reddy
Published: November 2023

BACKGROUND:

Foxtail millet (FM; Setaria italica (L.) P.Beauv.) is known for its antioxidant and neuroprotective action against Alzheimer's disease (AD); hence the present study aims to screen its polyphenols to find less toxic and potentially effective anti-Alzheimer's drugs.

MATERIALS AND METHODS:

The details about phyto-compounds of FM and the β-secretase enzyme (BACE 1) of AD have been retrieved from the PubChem compound database and protein data bank, respectively. The Patch Dock server was used to carry out docking experiments. Initially, all the FM phytocompounds and reference drug (MK-8931) were subjected to docking, and subsequently, the best-docked complexes were selected based on their binding energy (in kcal/mol). Rule of five and adsorption, distribution, metabolism, excretion, and toxicity (ADMET) of selected compounds were analyzed using various computational tools. The final docking complexes were developed by using PyMOL.

RESULTS:

The molecular docking results revealed that among the 24 polyphenols studied, two compounds, namely N′-p-coumaroyl-N″-caffeoylspermidine (NPCNCS) and di-P-coumaroylspermidine (DPCS), demonstrated strong binding to the active site of β-secretase. and exhibited higher binding energies of -300.75 kcal/mol and -193.41 kcal/mol, respectively, in comparison to the reference drug MK-8931, with a binding energy of -154.36 kcal/mol. These compounds established hydrogen bond interactions with catalytic dyad (Asp 32 and Asp 228) and other accessory interactions with residues of the “flap” hairpin loop and “10s loop” of the β-secretase active site involved in the stabilization of substrate/inhibitor binding. In a nutshell, the NPCNCS and DPCS have shown more robust binding affinity than MK-8931 and docked well into the interior side of the active site. On the other hand, NPCNCS and DPCS have satisfied the RO5 and ADMET filters.

CONCLUSIONS:

The in silico analysis of FM polyphenols revealed that the N′-p-coumaroyl-N″-feruloylspermidine and di-P-coumaroylspermidine compounds exhibited non-toxic, permeability to blood-brain barrier and solid binding affinity toward β-secretase enzyme thereby; these millet compounds might be considered as β-secretase inhibitors for treating AD.
Millets: Empowering the society with nutrient-rich superfoods to achieve sustainable development goals
Authors: Patil Pradeep B , Goudar Giridhar , Preethi Kommunuri , Rao Jarapala Sreenivasa , Acharya Rabinarayan
Published: November 2023

Despite remarkable scientific progress in agriculture and medical sciences, the underlying causes of malnutrition and poverty remain stubborn challenges. This could be attributed to our limited comprehension on the intricate interplay of tradition, cultture, and the economy influence various facets of health. In the past, the sustainable practice of cultivating millets through natural and integrated farming, alongside mixed crop agriculture, played a vital role in maintaining a balanced lifestyle. Unfortunately, this valuable tradition has been neglected over time, partly due to various reasons and a lack of awareness. However, this presents an opportune moment to re-evaluate the potential of millets, not only for their health benefits but also for their positive impact on the environment and agricultural resilience. The Government of India (GoI) has taken steps in promoting millets through various programs and initiatives. Additionally, raising awareness through publications and validating traditional practices with scientific methods will not only facilitate research but also strengthen the bond between people, science, and their cultural heritage. Nonetheless, reintroducing millets into the Indian diet faces considerable challenges, primarily due to the pervasive influence of existing advertisements promoting cereal-based products, internal kitchen politics within households, market-driven agricultural practices, and economic factors. Despite these obstacles, the current manuscript aims to provide insights into developing a roadmap that enables the achievement of sustainable development goals through the integration of millets.
An incisive review on Buckwheat—A potential underutilized millet
Authors: Tamchos Sonam , Anjum Talat , Singh Sanjay Kumar
Published: November 2023

Buckwheat is a short-season, multi-nutrient crop commonly known as “Kuttu” in India and used to make flour “Kuttu ka Atta” and utilized to prepare a variety of dishes. Buckwheat has small, triangular seeds, frequently used as substitutes for cereals like wheat and rice and commonly cultivated at high altitudes, particularly >1000 masl, where other cereal crops are not as readily available. It is relatively easy to grow, adapts well to various soil types, requires little water, and thrives in moderately fertile soil, which makes it an ideal crop for farmers where water sis scarece and soil is not fertile. Buckwheat is a gluten-free grain that contains carbohydrates, phenolics, protein, dietary fiber, omega-3 and omega-6 fatty acids, and vitamins. Furthermore, it is also said to be beneficial in a number of diseases such as Zn, Cu, Fe, P, Mn, and Mg. Buckwheat has also been used to treat a number of diseases like high blood pressure, digestive troubles, skin problems, and so on. Coordinated efforts are required to improve production and encourage consumption of buckwheat.
Millets: The sustainable ancient superfood for the modern world
Authors: Chauhan Dixha , Sethi Lincon , Tyagi Monika , Sharma Sakshi
Published: November 2023

Millets are a category of small-seeded, nutrition-rich grains that have been integral to human subsistence for thousands of years, especially in Africa and Asia. The most extensively grown millets worldwide, notably in India, are pearl millet, finger millet, foxtail millet, Indian barnyard millet, kodo millet, little millet, and proso millet. Millets are explicated under Dhanya Varga in Ayurveda and are referred to by the names Trina Dhanya, Kudhanya, and Kshudra Dhanya across various Samhita. Moreover, indigenous people have long used millets for ethnomedical purposes and prevention of hunger. Millets are a highly resilient crop since they are typically grown on degraded and nutrient-deficit soil receiving little rainfall. Millets are a panacea to various health disorders as they are rich in dietary fiber, proteins, vitamins, minerals, antioxidants, phytochemicals, etc. Millets have surfaced as a possible option to solve current difficulties in the field of agriculture, food security, and public health as there has been a decrease in the yield of main staple grains due to changing agro-climatic conditions for which millets have shown great adaptability with excellent nutritional makeup. This research paper provides a concise overview of millets, highlighting their historical significance, folklore use, cultivation practices, health benefits, their potential to contribute to sustainable farming systems, and food security with government and civil society efforts to encourage millet farming in India. Various Ayurveda literatures, journals, published articles, and books were comprehensively reviewed for this research paper.
Trinadhanya as a new era super-food: Revival of interest in traditional millet for their nutritional and therapeutic benefits
Authors: Tiwari Adarsh , Misra Ankita , Srivastava Sharad
Published: November 2023

There has been a remarkable revival of interest in traditional millets, collectively known as “Trinadhanya” in Ayurveda, due to their nutritional and medicinal properties and, have established themselves as a new era superfood. The present article enlightens Indian traditional millets, showcasing their diverse nutritional profiles comprising carbohydrates, proteins, vitamins, and minerals. Further, the diverse range of phytochemical constituents present in millets has also been focused. Besides the nutritional value, the article also elucidates the biological efficacy of traditional millets, unveiling their positive impacts on various health conditions, such as glycemic control, cardiovascular diseases, and healthy gut microflora. The study also elaborates the millet-based recipes, showcasing their versatility in culinary applications. Furthermore, the article contextualizes the resurgence of traditional millets within the framework of Sustainable Development Goal 3 (SDG-3) to combat malnutrition, ensure healthy lives, and promote well-being for all with indigenous crops.
Real-life experiences and barriers to adjuvant chemotherapy in Saudi patients with advanced stage II and stage III colon cancer
Authors: Alyabsi Mesnad S. , Alqarni Anwar H. , Almutairi Adel F. , Alselaim Nahar A. , Algarni Mohammed A. , Alshammari Kanan M.
Published: November 2023

Background:

Colorectal cancer is the most common malignancy in Saudi males and third most common in females. Patients with locally advanced colon cancer may eventually develop metastatic disease if not treated promptly and according to guidelines. The recent National Comprehensive Cancer Network guideline recommends tumor resection followed by adjuvant chemotherapy for stage III and high-risk stage II tumors. Therefore, the objective of this study was to characterize patients with locally advanced colon cancer and identify factors associated with the use of adjuvant chemotherapy and the addition of oxaliplatin in locally advanced colon cancer patients.

Methods:

All patients diagnosed with locally advanced colon cancer at National Guard Health Affairs (NGHA) during 2016-2021 were investigated. Patients’ characteristics were compared using Chi-square and Fisher exact test, whereas predictors of adjuvant chemotherapy/Oxaliplatin use were identified using univariate and multivariate logistic regression.

Results:

Out of 222 patients diagnosed with locally advanced colon cancer, 133 received adjuvant chemotherapy. Factors associated with adjuvant chemotherapy administration were age and smoking status. In the multivariable analysis, older patients were less likely to receive oxaliplatin than younger patients. Stage III patients diagnosed during 2019-2021 had 5.61 times higher odds of receiving oxaliplatin.

Conclusion:

The findings of this study show that older patients and smokers are less likely to be treated with adjuvant chemotherapy. Moreover, age as well as diagnosis year were important determinants of oxaliplatin administration in stage III locally advanced colon cancer patients.
Mediterranean diet as a modifiable risk factor for age-related macular degeneration: A systematic review and meta-analysis
Authors: Angelia Maria , Amelia Yufilia Suci , Pratama Kevin Gracia
Published: November 2023

Objectives:

Age-related macular degeneration (AMD) is a chronic and degenerative disease of the retina that leads to irreversible blindness. There is no proven effective treatment for early AMD and advanced AMD. Mediterranean diet (MD) has been linked to reducing the risk or delaying the progression of AMD. Therefore, in this study, we aim to investigate the potential of MD as a modifiable risk factor for AMD.

Materials and Methods:

A systematic search was performed in three databases: PubMed, EBSCO host, and Proquest. We search for studies that determine the association of MD in AMD. Then, we pooled the data for meta-analysis.

Results:

Eight studies were included in our systematic review. Seven studies were included for meta-analysis. Subjects with medium–high (hazard ratio [HR] 0.82; 95% confidence interval [CI]: 0.75–0.90) adherence to the MD showed a reduced risk of developing AMD. Moreover, medium adherence AMD shows a significant and inverse relationship with the progression to advanced AMD (HR: 0.87; 95% CI: 0.81–0.93). Although it is still inconsistent, the reduction appears stronger for geographic atrophy than for neovascular AMD.

Conclusion:

Adhering to the MD, particularly at a medium to high level, appears to confer a protective effect against AMD. The sub-analysis demonstrates even that there is a protective effect associated with moderate adherence against advanced AMD. The presence of considerable heterogeneity within the results warrants cautious interpretation. Further research is needed to enhance our understanding.
A Novel Approach to Identify the Brain Tumour Using Convolutional Neural Network
Authors: Khari Suraj , Gupta Deepa , Chaudhary Alka , Bhatla Ruchika
Published: November 2023

INTRODUCTION: Determining the possibility that an individual is affected by a tumour is an intricate process in today's modern technological and biological age, when feats are reaching unprecedented levels with every passing second. Machine learning modalities could dramatically enhance the accuracy of diagnosis.
OBJECTIVES: Our research makes it feasible to detect tumours early, aiding in early diagnosis, and is a necessity for the curative efforts of cancer patients.
METHODS: In our research model Convolutional Neural Network (CNN) was implemented using Jupiter to give an accurate result.
RESULTS: In our proposed model we got 99% accuracy that is higher than the other results.
CONCLUSION: Our research demonstrates the potential of using machine learning techniques to improve the accuracy and efficiency of medical diagnosis.