bluuebunny/crossref_metadata_2025 huggingface dataset:
Climate Change, Forest Fires, and Territorial Dynamics in the Amazon Rainforest: An Integrated Analysis for Mitigation Strategies
Authors: Celis Nathalia , Casallas Alejandro , Lopez-Barrera Ellie Anne , Felician Martina , De Marchi Massimo , Pappalardo Salvatore E.
Published: October 2023

Recent times have witnessed wildfires causing harm to both ecological communities and urban–rural regions, underscoring the necessity to comprehend wildfire triggers and assess measures for mitigation. This research hones in on Cartagena del Chairá, diving into the interplay between meteorological conditions and land cover/use that cultivates a conducive environment for wildfires. Meteorologically, the prevalence of wildfires is concentrated during boreal winter, characterized by warm and dry air, strong winds, and negligible precipitation. Additionally, wildfires gravitate toward river-adjacent locales housing agriculture-linked shrubs, notably in the northern part of the zone, where a confluence of land attributes and meteorological factors synergize to promote fire incidents. Employing climate scenarios, we deduced that elevated temperature and reduced humidity augment wildfire susceptibility, while wind speed and precipitation discourage their propagation across most scenarios. The trajectory toward a warmer climate could instigate fire-friendly conditions in boreal summer, indicating the potential for year-round fire susceptibility. Subsequently, via machine-learning-driven sensitivity analysis, we discerned that among the scrutinized socio-economic variables, GINI, low educational attainment, and displacement by armed groups wield the most substantial influence on wildfire occurrence. Ultimately, these findings converge to shape proposed wildfire mitigation strategies that amalgamate existing practices with enhancements or supplementary approaches.
Artificial Intelligence: A Blessing or a Threat for Language Service Providers in Portugal
Authors: Tavares Célia , Oliveira Luciana , Duarte Pedro , da Silva Manuel Moreira
Published: October 2023

According to a recent study by OpenAI, Open Research, and the University of Pennsylvania, large language models (LLMs) based on artificial intelligence (AI), such as generative pretrained transformers (GPTs), may have potential implications for the job market, specifically regarding occupations that demand writing or programming skills. This research points out that interpreters and translators are one of the main occupations with greater exposure to AI in the US job market (76.5%), in a trend that is expected to affect other regions of the globe. This article, following a mixed-methods survey-based research approach, provides insights into the awareness and knowledge about AI among Portuguese language service providers (LSPs), specifically regarding neural machine translation (NMT) and large language models (LLM), their actual use and usefulness, as well as their potential influence on work performance and the labour market. The results show that most professionals are unable to identify whether AI and/or automation technologies support the tools that are most used in the profession. The usefulness of AI is essentially low to moderate and the professionals who are less familiar with it and less knowledgeable also demonstrate a lack of trust in it. Two thirds of the sample estimate negative or very negative effects of AI in their profession, expressing the devaluation and replacement of experts, the reduction of income, and the reconfiguration of the career of translator to mere post-editors as major concerns.
Electrolyte Disturbances Related to Sodium and Potassium and Electroconvulsive Therapy: A Systematic Review
Authors: Gędek Adam , Materna Michał , Majewski Paweł , Antosik Anna Z. , Dominiak Monika
Published: October 2023

Introduction: Electrolyte disturbances related to sodium and potassium affect patients with mental disorders undergoing electroconvulsive therapy (ECT). The objective of this study was to systematically summarize the data regarding ECT and electrolyte disturbances related to sodium and potassium. Materials and methods: A systematic literature review in accordance with PRISMA guidelines was conducted. Clinical studies of patients receiving ECT with electrolyte disturbances reported before or after treatment were included. Results: We identified nine case reports and two retrospective studies describing electrolyte abnormalities occurring before or after ECT. ECT was effective and safe in patients with hyponatremia and hypernatremia, including the elderly patient population. This treatment was also effective in treating psychiatric symptoms that may persist after ionic equalization. Electrolyte disturbances after ECT were rare. Reports have suggested that succinylcholine used as a muscle relaxant was the main cause of hyperkalemia after ECT. Conclusions: Electrolyte control is a crucial aspect of guiding ECT therapy. In the context of sodium-related disorders, it is critical to control patient hydration as part of therapy. In addition, succinylcholine should not be used in patients with immobilization, such as catatonia or neuroleptic malignant syndrome. It is necessary to conduct further studies to clarify whether electrolyte concentration affects ECT parameters and clinical efficacy. In addition, it is necessary to assess the influence of various anesthetics on these conditions during ECT. The result of this review should be interpreted bearing in mind the small number of studies conducted to date and the low quality of the evidence they provide.
Silver-Coated Distal Femur Megaprosthesis in Chronic Infections with Severe Bone Loss: A Multicentre Case Series
Authors: Fiore Michele , Sambri Andrea , Morante Lorenzo , Bortoli Marta , Parisi Stefania Claudia , Panzavolta Francesco , Alesi Domenico , Neri Elisabetta , Neri Maria Pia , Tedeschi Sara , Zamparini Eleonora , Cevolani Luca , Donati Davide Maria , Viale Pierluigi , Campanacci Domenico Andrea , Zaffagnini Stefano , De Paolis Massimiliano
Published: October 2023

Periprosthetic joint infections (PJI) and fracture-related infections (FRI) of the distal femur (DF) may result in massive bone defects. Treatment options include articulated silver-coated (SC) megaprosthesis (MP) in the context of a two-stage protocol. However, there is limited evidence in the literature on this topic. A retrospective review of the prospectively maintained databases of three Institutions was performed. Forty-five patients were included. The mean follow-up time was 43 ± 17.1 months. Eight (17.8%) patients had a recurrent infection. The estimated recurrence-free survival rate was 91.1% (93.5% PJI vs. 85.7% FRI) 2 years following MP implantation, and 75.7% (83.2% PJI vs. 64.3% FRI; p = 0.253) after 5 years. No statistically relevant difference was found according to the initial diagnosis (PJI vs. FRI). Among possible risk factors, only resection length was found to significantly worsen the outcomes in terms of infection control (p = 0.031). A total of eight complications not related to infection were found after reimplantation, but only five of them required further surgery. Above-the-knee amputation was performed in two cases (4.4%), both for reinfection. Articulated DF SC MP in a two-stage protocol is a safe and effective treatment for chronic knee infection with severe bone loss.
The Impact of Progressive Pulmonary Fibrosis in Systemic Sclerosis–Associated Interstitial Lung Disease
Authors: Martín-López María , Carreira Patricia E.
Published: October 2023

Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by immune dysregulation and progressive fibrosis, typically affecting the skin, with variable internal organ involvement. Interstitial lung disease (ILD), with a prevalence between 35 and 75%, is the leading cause of death in patients with SSc, indicating that all newly diagnosed patients should be screened for this complication. Some patients with SSc-ILD experience a progressive phenotype, which is characterized by worsening fibrosis on high-resolution computed tomography (HRCT), a decline in lung function, and premature mortality. To assess progression and guide therapeutic decisions, regular monitoring is essential and should include pulmonary function testing (PFT), symptom assessment, and repeat HRCT imaging when indicated. Multidisciplinary discussion allows a comprehensive evaluation of the available information and its consequences for management. There has been a shift in the approach to managing SSc-ILD, which includes the addition of targeted biologic and antifibrotic therapies to standard immunosuppressive therapy (particularly mycophenolate mofetil or cyclophosphamide), with autologous hematopoietic stem-cell transplantation and lung transplantation reserved for refractory cases.
The Zygomatic Anatomy-Guided Approach, Zygomatic Orbital Floor Classification, and ORIS Criteria—A 10-Year Follow-Up
Authors: Zielinski Rafal , Okulski Jakub , Simka Wojciech , Kozakiewicz Marcin
Published: October 2023

Background: Presently, the management of patients with maxilla bone defects of the Cawood V or VI class is achieved using zygomatic or individual implants or through augmentation of the bone. For zygomatic implants, the ORIS criteria represent the most common factor in helping practitioners register success rates. The zygomatic anatomy-guided approach (ZAGA)and zygomatic orbital floor (ZOF) are factors that are crucial to examining the anatomy of a particular patient before the procedure. The aim of thisarticle is to find the statistical relationship between the abovementioned terms and other factors. Methods: A total of 81 patients underwent zygomatic implant procedures in different configurations. The ORIS, ZAGA, and ZOF parameters were compared with other factors such as type of surgery, sex, age, and the anatomy of the zygomatic bone. Results: Most patients in this article were classified as ZAGA Class 2. The relationships between type of surgery and ZAGA classification, and ZAGA and sinus/maxilla zygomatic implant localization were statistically significant. Conclusions: The ZAGA and ZOF scales are practical and valuable factors that should be taken into account before surgery, whereas to date, criteria better than the ORIS scale have not been described in terms of the success of zygomatic implants. The ZOF scale might omit perforation of the orbit because this parameter warns a practitioner to be aware of the anatomy of the orbit.
Celecoxib Suppresses NF-κB p65 (RelA) and TNFα Expression Signaling in Glioblastoma
Authors: Ahsan Hina , Malik Shaukat Iqbal , Shah Fawad Ali , El-Serehy Hamed A. , Ullah Amin , Shah Zafar Abbas
Published: October 2023

Background: Glioblastoma (GBM) harbors significant genetic heterogeneity, high infiltrative capacity, and patterns of relapse following many therapies. The expression of nuclear factor kappa-B (NF-κB p65 (RelA)) and signaling pathways is constitutively activated in GBM through inflammatory stimulation such as tumor necrosis factor-alpha (TNFα), cell invasion, motility, abnormal physiological stimuli, and inducible chemoresistance. However, the underlying anti-tumor and anti-proliferative mechanisms of NF-κB p65 (RelA) and TNFα are still poorly defined. This study aimed to investigate the expression profiling of NF-κB p65 (RelA) and TNFα as well as the effectiveness of celecoxib along with temozolomide (TMZ) in reducing the growth of the human GBM cell line SF-767. Methods: genome-wide expression profiling, enrichment analysis, immune infiltration, quantitative expression, and the Microculture Tetrazolium Test (MTT) proliferation assay were performed to appraise the effects of celecoxib and TMZ. Results: demonstrated the upregulation of NF-κB p65 (RelA) and TNFα and celecoxib reduced the viability of the human glioblastoma cell line SF-767, cell proliferation, and NF-κB p65 (RelA) and TNFα expression in a dose-dependent manner. Overall, these findings demonstrate for the first time how celecoxib therapy could mitigate the invasive characteristics of the human GBM cell line SF-767 by inhibiting the NF-κB mediated stimulation of the inflammatory cascade. Conclusion: based on current findings, we propose that celecoxib as a drug candidate in combination with temozolomide might dampen the transcriptional and enzymatic activities associated with the aggressiveness of GBM and reduce the expression of GBM-associated NF-κB p65 (RelA) and TNFα inflammatory genes expression.
Risk Factors for Recurrent Exacerbations in the General-Practitioner-Based Swiss Chronic Obstructive Pulmonary Disease (COPD) Cohort
Authors: Abu Hussein Nebal S. , Giezendanner Stephanie , Urwyler Pascal , Bridevaux Pierre-Olivier , Chhajed Prashant N. , Geiser Thomas , Joos Zellweger Ladina , Kohler Malcolm , Miedinger David , Pasha Zahra , Thurnheer Robert , von Garnier Christophe , Leuppi Joerg D.
Published: October 2023

Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer from acute exacerbations. Our objective was to describe recurrent exacerbations in a GP-based Swiss COPD cohort and develop a statistical model for predicting exacerbation. Methods: COPD cohort demographic and medical data were recorded for 24 months, by means of a questionnaire—based COPD cohort. The data were split into training (75%) and validation (25%) datasets. A negative binomial regression model was developed using the training dataset to predict the exacerbation rate within 1 year. An exacerbation prediction model was developed, and its overall performance was validated. A nomogram was created to facilitate the clinical use of the model. Results: Of the 229 COPD patients analyzed, 77% of the patients did not experience exacerbation during the follow-up. The best subset in the training dataset revealed that lower forced expiratory volume, high scores on the MRC dyspnea scale, exacerbation history, and being on a combination therapy of LABA + ICS (long-acting beta-agonists + Inhaled Corticosteroids) or LAMA + LABA (Long-acting muscarinic receptor antagonists + long-acting beta-agonists) at baseline were associated with a higher rate of exacerbation. When validated, the area-under-curve (AUC) value was 0.75 for one or more exacerbations. The calibration was accurate (0.34 predicted exacerbations vs 0.28 observed exacerbations). Conclusion: Nomograms built from these models can assist clinicians in the decision-making process of COPD care.
Do Judgments of Learning Impair Recall When Uninformative Cues Are Salient?
Authors: Double Kit S.
Published: October 2023

Judgments of learning (JOL) are one of the most commonly used measures of metamemory. There is mixed evidence that eliciting JOLs while participants are studying word pairs influences their subsequent recall, a phenomenon known as reactivity. The majority of studies have found that positive reactivity occurs when word pairs are related. This finding suggests that when the final test is sensitive to the cues used to make a JOL (e.g., pair relatedness), a benefit to recall is observed. Here, in three experiments, JOL reactivity is examined in the presence of a salient, yet non-diagnostic cue—font size. The results show that when study time is limited and font size is made salient, eliciting JOLs impairs future recall. It is argued that JOLs prompt participants to evaluate salient cues in the learning environment to evaluate whether they will affect future recall. This increased processing of salient cues can impair recall if it comes at the expense of processing less salient but more informative cues. These findings suggest that the relevance to the test of the cues processed when JOLs are performed determines the direction of reactivity effects, with both positive and negative reactivity being possible depending on how diagnostic the salient metacognitive cues are for recall.
Vortex-Induced Vibration and Fatigue Damage Assessment for a Submarine Pipeline on a Sand Wave Seabed
Authors: Zou Xing , Xie Botao , Zang Zhipeng , Chen Enbang , Hou Jing
Published: October 2023

Sand waves are commonly formed on the sandy seabed of the continental shelf and characterized by their regular wave-like shape. When a submarine pipeline is laid on this type of seabed, it often experiences free spans due to the unevenness of the seabed. These free spans are particularly vulnerable to vortex-induced vibration (VIV) and the resulting fatigue damage, which have been identified as the primary causes of pipeline failures in offshore oil and gas exploration. This study examines the VIV and fatigue damage of free spans in a submarine pipeline in the Lufeng oilfield, which is located in a large area of sand waves. The assessment conditions encompass the as-laid empty state, the flooded state, and the operational state. Additionally, both the minimum and maximum lay tension are taken into account during the evaluation of VIV and fatigue. The VIV onset screening conducted revealed a considerable number of pipeline free spans exceeding the VIV onset span lengths under both temporary and operating conditions for the non-trench seabed. Furthermore, the analyses indicate that the pipeline does not meet the criteria for VIV fatigue on a non-trenched seabed. Consequently, a proposed solution of implementing a 1 m trench rectification measure for the seabed is recommended. The results demonstrate that this measure effectively mitigates the occurrence of VIV and subsequently reduces fatigue damage across all conditions.
Species Diversity of Lycoperdaceae (Agaricales) in Israel, with Some Insights into the Phylogenetic Structure of the Family
Authors: Krakhmalnyi Maxim , Isikhuemhen Omoanghe S. , Jeppson Mikael , Wasser Solomon P. , Nevo Eviatar
Published: October 2023

The diversity of Lycoperdaceae in Israel was studied. Molecular phylogenetic relationships within the family, and genus Lycoperdon in particular, were inferred using original ITS rDNA sequences of 58 samples belonging to 25 species from Israel and six other countries, together with 66 sequences stored in the GenBank database. The current molecular phylogenetic study recovered the family Lycoperdaceae as a monophyletic group, which was supported in both maximum likelihood and Bayesian analyses. The clades corresponding to the genera Apioperdon, Bovista, Calvatia, Disciseda, and Lycoperdon were revealed. The taxonomic structure of the named genera was partially resolved. Within the genus Lycoperdon, some species received significant statistical support; however, their relationships, as well as the problem of the genus monophyly, mostly remained questionable. As a result of a thorough literature survey, extensive sample collection, and studies of the material stored in the Herbarium of the Institute of Evolution, University of Haifa (HAI, Israel), fifteen species representing five genera were found in the territory of Israel. Six species, namely Apioperdon pyriforme, Bovista aestivalis, Calvatia candida, Lycoperdon decipiens, L. niveum, and L. perlatum, are new additions to the diversity of Lycoperdaceae in Israel. Detailed macro- and micromorphological descriptions, ecology, geography, and critical notes, together with light microscopy photos and SEM micrographs, are provided. In-depth discussion on some taxonomically challenging species is presented.
The Role of Vitamins in Oral Potentially Malignant Disorders and Oral Cancer: A Systematic Review
Authors: See Jewel Kai Lin , Liu Xinyao , Canfora Federica , Moore Caroline , McCullough Michael , Yap Tami , Paolini Rita , Celentano Antonio
Published: October 2023

Background: Micronutrients are vital for general and oral health, and their potential anti-cancer properties are documented. We explore beneficial vitamins for oral potentially malignant disorders (OPMDs) and oral cancer (OC), assessing the therapeutic impacts of essential vitamin supplementation. Methods: We systematically review evidence on vitamin supplementation’s therapeutic effects for OPMDs and OC. Relevant studies were identified through comprehensive searches of MEDLINE, Evidence-Based Medicine, and Web of Science until 16 May 2023. All studies underwent risk of bias using criteria modified from the Office of Health Assessment and Translation (OHAT) tool. Results: We analysed 80 papers. Vitamin K, studied in vitro, shows promising therapeutic potential. Vitamin C, investigated in vivo (animals and humans), demonstrated mixed animal results and generally positive human trial effects. Vitamin A’s efficacy varied, with positive monotherapy or adjunct effects. Vitamins B and D showed therapeutic benefits. Oral cancer research was extensive, with a focus on oral lichen planus and oral leukoplakia among the 11 OPMDs. All bias levels were reported in ‘selective reporting’ and ‘performance’, except for “definitely high” in the ‘selection’, ‘detection’, and ‘attrition/exclusion’ domains. Conclusions: Evidence of vitamin interventions for OPMDs and OC ranges from mixed to promising. Standardizing the study design and outcomes would enhance future research.
Digital Twins in Healthcare: Methodological Challenges and Opportunities
Authors: Meijer Charles , Uh Hae-Won , el Bouhaddani Said
Published: October 2023

One of the most promising advancements in healthcare is the application of digital twin technology, offering valuable applications in monitoring, diagnosis, and development of treatment strategies tailored to individual patients. Furthermore, digital twins could also be helpful in finding novel treatment targets and predicting the effects of drugs and other chemical substances in development. In this review article, we consider digital twins as virtual counterparts of real human patients. The primary aim of this narrative review is to give an in-depth look into the various data sources and methodologies that contribute to the construction of digital twins across several healthcare domains. Each data source, including blood glucose levels, heart MRI and CT scans, cardiac electrophysiology, written reports, and multi-omics data, comes with different challenges regarding standardization, integration, and interpretation. We showcase how various datasets and methods are used to overcome these obstacles and generate a digital twin. While digital twin technology has seen significant progress, there are still hurdles in the way to achieving a fully comprehensive patient digital twin. Developments in non-invasive and high-throughput data collection, as well as advancements in modeling and computational power will be crucial to improve digital twin systems. We discuss a few critical developments in light of the current state of digital twin technology. Despite challenges, digital twin research holds great promise for personalized patient care and has the potential to shape the future of healthcare innovation.
The Emergence of Tab in Najdi Arabic
Authors: Almossa Amereh Ibrahim
Published: October 2023

This study empirically investigates functional and social variation in the use of TAYYIB (‘okay, well, right’) in light of grammaticalisation. Thirty naturally occurring conversations of 60 Najdi Arabic speakers were recorded in Riyadh, Saudi Arabia. The analysis demonstrates that TAYYIB has two realisations: full Tayyib [tˁajjib] and reduced Tab [tˁab]. Drawing on the conversation analytic approach within a variationist framework, TAYYIB was used to perform multiple discourse-pragmatic functions: interpersonal, textual and interpersonal–textual. The statistical analysis reveals that variant choice is significantly conditioned by the pragmatic functions. While Tayyib is employed to perform all three functions, Tab is only used for textual and interpersonal–textual meanings. As for social factors, Tab is significantly more likely to be used by younger speakers than adults and also more likely to be used by females than males. This can be interpreted as an indication of ongoing change driven by young people, primarily females, towards the greater use of the innovative Tab. Given the evidence of linguistic change in Tab including semantic bleaching, pragmatic strengthening and phonological reduction, the study suggests that Tab has undergone advanced grammaticalisation.
Combined Metabolome and Transcriptome Analysis of Creamy Yellow and Purple Colored Panax notoginseng Roots
Authors: He Muhan , Zhang Guanghui , Huo Dongfang , Yang Shengchao
Published: October 2023

Panax notoginseng (Burk.) F.H. Chen is a species of the Araliaceae family that inhabits southwestern China, Burma, and Nepal. It is cultivated on a commercial scale in Yunnan province, China, owing to its significance in traditional Chinese medicine. Panax notoginseng roots are usually yellow-white (HS); however, purple roots (ZS) have also been reported. The majority of P. notoginseng research has concentrated on the identification and production of natural chemicals in HS; however, there is little to no information about the composition of ZS. Using UPLC-MS/MS, we investigated the global metabolome profile of both ZS- and HS-type roots and discovered 834 metabolites from 11 chemical groups. There were 123 differentially accumulated metabolites (DAM) in the HS and ZS roots, which were classified as lipids and lipid-like molecules, polyketides, organoheterocyclic chemicals, and organooxygen compounds. We investigated the associated compounds in the DAMs because of the importance of anthocyanins in color and saponins and ginsenosides in health benefits. In general, we discovered that pigment compounds such as petunidin 3-glucoside, delphinidin 3-glucoside, and peonidin-3-O-beta-galactoside were more abundant in ZS. The saponin (eight compounds) and ginsenoside (26 compounds) content of the two varieties of roots differed as well. Transcriptome sequencing revealed that flavonoid and anthocyanin production genes were more abundant in ZS than in HS. Similarly, we found differences in gene expression in genes involved in terpenoid production and related pathways. Overall, these findings suggest that the purple roots of P. notoginseng contain varying amounts of ginsenosides and anthocyanins compared to roots with a creamy yellow color.
Pemafibrate Improves Alanine Aminotransferase Levels Independently of Its Lipid-Lowering Effect
Authors: Watanabe Azuma , Horigome Ryoko , Nakatsuka Yumiko , Terai Shuji
Published: October 2023

Aim: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. Pemafibrate, a selective peroxisome-proliferator-activated receptor α modulator (SPPARMα), has been reported to ameliorate liver function among patients with dyslipidemia. However, there are not many reports of the clinical effects of pemafibrate. This study aims to summarize the experience of using pemafibrate and analyze the effects on liver function in patients with dyslipidemia. Methods: One hundred twelve cases of hyperlipidemia receiving pemafibrate 0.2 mg/day were retrospectively enrolled in this study. Age, gender, BMI, complications, concomitant medications, serum parameters (TG, HDL-C, LDL-C, AST, ALT, γGTP, ALP, platelets, M2BPGi, Cre, eGFR, HbA1c, blood glucose level at any time) were investigated and evaluated. Results: Pemafibrate administration significantly improved serum TG and HDL-C, but not in LDL-C. Serum AST, ALT, γGTP, and ALP were also significantly improved. The fib-4 index, a liver fibrosis score, did not significantly change, but M2-BPGi, an index of fibrosis, significantly decreased. No correlation was observed between each lipid parameter and ALT, and ALT decreased independently of the lipid parameters. Conclusions: As we expected, pemafibrate demonstrated a lipid-improving effect without adversely affecting hepatic and renal functions. An unexpected finding was the decrease in ALT that was independent of lipid parameters.
Progress in the Synthesis Process and Electrocatalytic Application of MXene Materials
Authors: Wang Peng , Wang Bingquan , Wang Rui
Published: October 2023

With their rich surface chemistry, high electrical conductivity, variable bandgap, and thermal stability, 2D materials have been developed for effective electrochemical energy conversion systems over the past decade. Due to the diversity brought about by the use of transition metals and C/N pairings, the 2D material MXene has found excellent applications in many fields. Among the various applications, many breakthroughs have been made in electrocatalytic applications. Nevertheless, related studies on topics such as the factors affecting the material properties and safer and greener preparation methods have not been reported in detail. Therefore, in this paper, we review the relevant preparation methods of MXene and the safer, more environmentally friendly preparation techniques in detail, and summarize the progress of research on MXene-based materials as highly efficient electrocatalysts in the electrocatalytic field of hydrogen precipitation reaction, nitrogen reduction reaction, oxygen precipitation reaction, oxygen reduction reaction, and carbon dioxide reduction reaction. We also discuss the technology related to MXene materials for hydrogen storage. The main challenges and opportunities for MXene-based materials, which constitute a platform for next-generation electrocatalysis in basic research and practical applications, are highlighted. This paper aims to promote the further development of MXenes and related materials for electrocatalytic applications.
Surface-Modified Electrospun Glass Nanofibers from Silane Treatment and Their Use for High-Performance Epoxy-Based Nanocomposite Materials
Authors: Mali Abhijeet , Agbo Philip , Mantripragada Shobha , Zhang Lifeng
Published: October 2023

As a new and promising reinforcing filler, electrospun glass nanofibers (EGNFs) have attracted attention in the field of polymer composite materials. However, the reinforcing effectiveness of surface-modified EGNFs using different silane coupling agents in epoxy resin is still not quite clear. In this research, a series of silane coupling agents with increasing chain lengths in the order of methyl trimethoxysilane (MTMS), (3-aminopropyl) triethoxysilane (APTES), (3-glycidyloxypropyl) trimethoxysilane (GPTMS), and dual silane coupling agent APTES–GPTMS were employed to carry out surface treatment on the EGNFs. The pristine and silane functionalized EGNFs were then incorporated into epoxy resin as reinforcing fillers at low loading levels, i.e., 0.25 wt.%, 0.5 wt.%, and 1 wt.%, and the mechanical properties of the resultant epoxy nanocomposites, including strength, stiffness, ductility, and toughness, were evaluated. A commercial product of glass nanoparticles (GNPs) was used as a control to compare the reinforcing effectiveness of the EGNFs and the GNPs. This study revealed that the EGNFs could provide significant reinforcing and toughening effects at ultra-low loading (0.25 wt.%) in epoxy nanocomposite materials. Furthermore, surface modification of the EGNFs with silane coupling agents with long chain lengths, e.g., by using dual silane coupling agents, APTES–GPTMS, could enhance the interfacial bonding between the EGNFs and the epoxy matrix and further increase the mechanical performance of the EGNF-reinforced epoxy nanocomposite materials. Through this research, we realized epoxy nanocomposite materials with much-improved mechanical properties, i.e., 37%, 24%, 18%, 57% improvement in strength, stiffness, ductility, and toughness, respectively, with respect to those of the cured neat epoxy material with an ultra-low loading (0.25 wt.%) of APTES–GPTMS–EGNFs. Our research paves the road for developing lighter and stronger epoxy nanocomposite materials with EGNFs.
Performance of the Cement Grouting Material and Optimization of the Mix Proportion for the Free Section of the Prestressed Anchor Bar
Authors: Wu Chaoguang , Chen Zhiya , Zhang Xuemin , Li Zikun , Wang Lichuan , Ouyang Bin , Liu Jin
Published: October 2023

Increasing the water–cement ratio and water-reducer dosage of cement slurry enhances its fluidity. However, a high water–cement ratio diminishes the beneficial effects of water reducers on fluidity. The stone content of the slurry decreases as the water-reducer dosage increases. Additionally, the water–cement ratio significantly affects stone content. However, when the water–cement ratio exceeds a threshold value, stone content decreases. Furthermore, the threshold value of the water–cement ratio decreases with increasing water-reducer dosage. Without the addition of the water reducer, as the water–cement ratio increases the overall integrity of the grout stone decreases. The addition of the water reducer alters the surface pore distribution, wherein “uniform small pores” change to “localized large pores.” Based on the multi-objective optimization of Matlab, the recommended optimal mix composition for a slow-setting cement slurry is a water–cement ratio of 0.25 and water-reducer dosage of 1.5%. With the use of this optimized mix composition, the stone content and compressive strength increase by 7.8% and 145.6%, respectively, compared to those obtained using the recommended mix ratio in the specifications. Additionally, all relevant performance parameters meet the requirements specified by previous standards.
Durability Analysis of CFRP Adhesive Joints: A Study Based on Entropy Damage Modeling Using FEM
Authors: Li Yutong , Deng Huachao , Takamura Maruri , Koyanagi Jun
Published: October 2023

Experimental methodologies for fatigue lifetime prediction are time-intensive and susceptible to environmental variables. Although the cohesive zone model is popular for predicting adhesive fatigue lifetime, entropy-based methods have also displayed potential. This study aims to (1) provide an understanding of the durability characteristics of carbon fiber-reinforced plastic (CFRP) adhesive joints by incorporating an entropy damage model within the context of the finite element method and (2) examine the effects of different adhesive layer thicknesses on single-lap shear models. As the thickness of the adhesive layer increases, damage variables initially increase and then decrease. These peak at 0.3 mm. This observation provides a crucial understanding of the stress behavior at the resin–CFRP interface and the fatigue mechanisms of the resin.
Surface Protection Technology for Metallic Materials in Marine Environments
Authors: Xu Jing , Lu Hao , Cai Linxuan , Liao Yihong , Lian Jiadi
Published: October 2023

As the demand for the development and utilization of marine resources continues to strengthen, the service requirements for advanced marine equipment are rapidly increasing. Surface protection technology has become an important way of solving the tribological problems of extreme operating conditions and improving the safety performance of equipment by imparting certain special properties to the surface of the material through physical, chemical or mechanical processes to enhance the ability of the material to withstand external environmental factors. Combined with the extremely complex characteristics of the marine environment, this paper describes the commonly used surface protection technologies for metal materials in the marine environment. Research on surface texture was summarized under different surface reshaping technologies, as well as processes and coating materials under different surface modification technologies. Combined with the existing research progress and development trends of marine metallic materials, the surfaces of metal materials under the marine environment protection technology foreground are prospected and provide a reference for the improvement of equipment performance in extreme marine environments.
Path Planning Algorithm for Dual-Arm Robot Based on Depth Deterministic Gradient Strategy Algorithm
Authors: Zhang Xiaomei , Yang Fan , Jin Qiwen , Lou Ping , Hu Jiwei
Published: October 2023

In recent years, the utilization of dual-arm robots has gained substantial prominence across various industries owing to their collaborative operational capabilities. In order to achieve collision avoidance and facilitate cooperative task completion, efficient path planning plays a pivotal role. The high dimensionality associated with collaborative task execution in dual-arm robots renders existing path planning methods ineffective for conducting efficient exploration. This paper introduces a multi-agent path planning reinforcement learning algorithm that integrates an experience replay strategy, a shortest-path constraint, and the policy gradient method. To foster collaboration and avoid competition between the robot arms, the proposed approach incorporates a mechanism known as “reward cooperation, punishment competition” during the training process. Our algorithm demonstrates strong performance in the control of dual-arm robots and exhibits the potential to mitigate the challenge of reward sparsity encountered during the training process. The effectiveness of the proposed algorithm is validated through simulations and experiments, comparing the results with existing methods and showcasing its superiority in dual-arm robot path planning.
Efficient Trajectory Planning for Optimizing Energy Consumption and Completion Time in UAV-Assisted IoT Networks
Authors: Li Mengtang , Jia Guoku , Li Xun , Qiu Hao
Published: October 2023

Quadrotor unmanned aerial vehicles (UAVs) have emerged as ubiquitous and agile robots and data carriers within the framework of the future Internet of Things (IoT) and mobile wireless networks. Yet, the insufficient onboard battery necessitates the optimization of energy consumption for both the UAV and IoT devices while ensuring that communication requirements are met. This paper therefore proposes a more accurate and mathematically tractable model for characterizing a UAV’s energy consumption concerning desired trajectories. This nonlinear model takes into account the UAV’s dynamics, brushless direct current (BLDC) motor dynamics, and aerodynamics. To optimize the communication time between IoT devices and the UAV, IoT devices are clustered using a modified GAK-means algorithm, with dynamically optimized communication coverage radii. Subsequently, a fly–circle–communicate (FCC) trajectory design algorithm is introduced and derived to conserve energy and save mission time. Under the FCC approach, the UAV sequentially visits the cluster centers and performs circular flight and communication. Transitions between cluster centers are smoothed via 3D Dubins curves, which provide physically achievable trajectories. Comprehensive numerical studies indicate that the proposed trajectory planning method reduces overall communication time and preserves UAV battery energy compared to other benchmark schemes.
Optimizing Traumatic Limb Salvage: Ectopic Implantation and Staged Rotationplasty
Authors: Hsieh Yi-Keng , Liu Chang-Heng , Hu Ching-Hsuan
Published: October 2023

Rotationplasty, a limb-saving procedure involving a 180-degree ankle rotation to function as a knee joint, is now standard for treating distal femur osteosarcoma. However, challenges related to self-identification persist within the Asian population. This study presents a case involving the successful application of temporary ectopic implantation followed by staged rotationplasty after a severe traumatic amputation, resulting in a favorable outcome. Additionally, a systematic review is conducted to summarize the various difficulties and complications encountered in different studies. This approach improves the feasibility of rotationplasty in traumatic cases and enhances patient and family comprehension.
Alloy and Process Design of Metallic Materials
Authors: Soliman Mohamed
Published: October 2023

Metallic materials have witnessed substantial developments over the past two decades [...]
Porous Microgels for Delivery of Curcumin: Microfluidics-Based Fabrication and Cytotoxicity Evaluation
Authors: Orbay Sinem , Sanyal Rana , Sanyal Amitav
Published: October 2023

Polymeric microgels, fabricated via microfluidic techniques, have garnered significant interest as versatile drug delivery carriers. Despite the advances, the loading and release of hydrophobic drugs such as curcumin from polymeric microgels is not trivial. Herein, we report that effective drug loading can be achieved by the design of porous particles and the use of supramolecular cyclodextrin-based curcumin complexes. The fabrication of porous microgels through the judicious choice of chemical precursors under flow conditions was established. The evaluation of the curcumin loading dependence on the porosity of the microgels was performed. Microgels with higher porosity exhibited better curcumin loading compared to those with lower porosity. Curcumin-loaded microgels released the drug, which, upon internalization by U87 MG human glioma cancer cells, induced cytotoxicity. The findings reported here provide valuable insights for the development of tailored drug delivery systems using a microfluidics-based platform and outline a strategy for the effective delivery of hydrophobic therapeutic agents such as curcumin through supramolecular complexation.
An Investigation into the Surface Integrity of Micro-Machined High-Speed Steel and Tungsten Carbide Cutting Tools
Authors: Dang Minh Nhat , Singh Surinder , Navarro-Devia John H. , King Hannah J. , Hocking Rosalie K. , Wade Scott A. , Stephens Guy , Papageorgiou Angelo , Wang James
Published: October 2023

The performance and lifespan of cutting tools are significantly influenced by their surface quality. The present report highlights recent advances in enhancing the surface characteristics of tungsten carbide and high-speed steel cutting tools using a novel micro-machining technique for polishing and edge-honing. Notably, the main aim was to reduce the surface roughness while maintaining the hardness of the materials at an optimal level. By conducting a thorough analysis of surfaces obtained using different techniques, it was found that the micro-machining method effectively decreased the surface roughness of the cutting tools the most effectively out of the techniques investigated. Significantly, the surface roughness was reduced from an initial measurement of 400 nm to an impressive value of 60 nm. No significant change in hardness was observed, which guarantees the maintenance of the mechanical properties of the cutting tools. This analysis enhances the comprehension of surface enhancement methodologies for cutting tools through the presentation of these findings. The observed decrease in surface roughness, along with the consistent hardness, exhibits potential for improving tool performance. These enhancements possess the capacity to optimise manufacturing processes, increase tool reliability, and minimise waste generation.
Experimental Investigation of the Effects of Machining Parameters on the Performance of Form-Cutting Tools Manufactured by Wire Electrical Discharge Machining (WEDM) and Grinding Processes
Authors: Alinaghizadeh Amir , Hadad Mohammadjafar , Azarhoushang Bahman
Published: October 2023

In this research, a comparison between two methods of grinding and WEDM and the chip formation of each form tool was studied through a set of designs of experiments. A multi-functional form tool with different cutting-edge shapes was designed to compare different production methods, and a grinding machine and a five-axis wire-cutting machine were made. The form tools by the wire cutting method were made with three different machining states, rough, semi-finish, and finish. The results of the experimental test showed that the chip formation of the finished surface of the wire cut tool was close to the ground tools. Additionally, the tool life in wear generation was assessed, revealing that the tool generated through the wire-cutting method with three passes exhibited superior performance compared to alternative approaches. Furthermore, employing the wire-cutting technique with high surface finishing yielded optimal outcomes for producing form-cutting tools featuring complex profiles.
Nonlinear Dynamic Analysis of an Electrostatically Actuated Clamped–Clamped Beam and Excited at the Primary and Secondary Resonances
Authors: Alneamy Ayman M.
Published: October 2023

This work investigates the primary and secondary resonances of an electrostatically excited double-clamped microbeam and its feasibility to be used for sensing applications. The sensor design can be excited directly in the vicinity of the primary and secondary resonances. This excitation mechanism would portray certain nonlinear phenomena and it would certainly lead in increasing the sensitivity of the device. To achieve this, a nonlinear beam model describing transverse deflection based on the Euler–Bernoulli beam theory was utilized. Then, a reduced-order model (ROM) considering all geometric and electrical nonlinearities was derived. Three different techniques involving time domain, fast Fourier transforms (FFTs), and frequency domain (FRCs) were used to examine the appearance of subharmonic resonance of order of one-half under various excitation waveforms. The results show that higher forcing levels and lower damping are required to activate this resonance. We note that as the forcing increases, the size of the instability region grows fast and the size of the unstable region increases rapidly. This, in fact, is an ideal place for designing bifurcation inertia MEMS sensors.
Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes
Authors: Yang Dong , Zhang Yanfang , Sow Ibrahima Sory , Liang Hongping , El Manssouri Naïma , Gelbcke Michel , Dong Lina , Chen Guangxin , Dufrasne François , Fontaine Véronique , Li Rongshan
Published: October 2023

Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different metal ions, including Fe(II/III), Ni(II), Cu(II) and Zn(II), were evaluated for their antimycobacterial activities and their anti-biofilm activities. Some derivatives showed antimycobacterial activities, especially in biofilm growth conditions. For example, 20–100 µM of HA10Fe2, HA10FeCl, HA10Fe3, HA10Ni2 or HA10Cu2 inhibited Mycobacterium tuberculosis, Mycobacterium bovis BCG and Mycobacterium marinum biofilm development. HA10Fe2, HA12Fe2 and HA12FeCl could even attack pre-formed Pseudomonas aeruginosa biofilms at higher concentrations (around 300 µM). The phthiocerol dimycocerosate (PDIM)-deficient Mycobacterium tuberculosis H37Ra was more sensitive to the ion complexes of HA compared to other mycobacterial strains. Furthermore, HA10FeCl could increase the susceptibility of Mycobacterium bovis BCG to vancomycin. Proteomic profiles showed that the potential targets of HA10FeCl were mainly related to mycobacterial stress adaptation, involving cell wall lipid biosynthesis, drug resistance and tolerance and siderophore metabolism. This study provides new insights regarding the antimycobacterial activities of HA and their complexes, especially about their potential anti-biofilm activities.