bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Material: Petrogenesis and tectonic setting of Neoarchean tonalitic-trondhjemitic-granodioritic gneisses in the Xiwulanbulang area of the Yinshan block, North China craton
Authors: Wang Xiao , Zhang Jian , al. et
Published: December 2024

Table S1: U-Pb dating results for zircons from the Xiwulanbulang tonalitic-trondhjemitic-granodioritic gneisses in the Yinshan block. Table S2: Major-element (wt%) and trace-element (ppm) compositions of the Xiwulanbulang TTG gneisses in the Yinshan block. Table S3: Zircon Hf isotopic data for the Xiwulanbulang TTG gneisses in the Yinshan block. Table S4: Whole-rock Sr-Nd isotopic compositions of the Xiwulanbulang TTG gneisses in the Yinshan block. Table S5: Whole-rock Pb isotopic compositions of the Xiwulanbulang TTG gneisses in the Yinshan block.
Supplemental Material: The Colorado Rocky Mountains awaken: Understanding topographic rejuvenation in postorogenic mountain belts
Authors: Marder Eyal , Gallen Sean F. , Lifton Nathaniel A. , Rittenour Tammy M.
Published: December 2024

Text S1. Supplementary details on the method used in the study; Figures S1–S3: River profile models and analyses; Figure S4: Detailed OSL results; Figure S5: Sensitivity analysis for topographic analysis; Tables S1–S2: Detailed information on 10Be basin-wide samples; Tables S3–S6: Detailed information on OSL samples.
Thermal control on the updip and downdip extents of megathrust earthquake rupture: revisiting Dr. Roy Hyndman's seminal contributions 30 years later
Authors: Wang Kelin
Published: December 2024

How far earthquake ruptures extend updip and downdip along subduction megathrusts has important science and hazard implications. In the Hyndman hypothesis proposed in the 1990s, the updip limit was set by a change in clay mineralogy at 100–150 °C, and the downdip limit by a temperature of ∼350 °C or the serpentinized mantle wedge corner (MWC), whichever was shallower. These limits were based on reported changes in fault friction behaviour with temperature and petrology. Many recent megathrust ruptures extended much beyond these limits, but the core idea of the hypothesis is still of great scientific value. Here, I highlight advances in earthquake science over the past three decades relevant to this subject and explain how the Hyndman hypothesis should be accordingly revised. The key point is that the clayey shallow segment of the megathrust and the MWC segment that is rich in lizardite serpentinite can act as “soft barriers” to seismic slip instead of hard limits. They impede seismic slip but may still participate in the slip while undergoing rate-strengthening, or they may even facilitate the slip by exhibiting dynamic weakening at high enough slip rates. In most subduction zones, antigorite serpentinites exhibit seismic behaviour to allow rupture to occur 10–20 km deeper than the MWC while radiating high-frequency seismic energy. In very warm subduction zones, seismic rupture is limited to be shallower than the MWC by thermally activated creep, and the ∼350 °C limit approximately holds. In this situation, the thermal and petrologic conditions at the MWC harbour Episodic Tremor and Slip.
Uncovering the complexity of structural variants in four individuals with autism spectrum disorder
Authors: Dada Sarah , Dixon Katherine , Akbari Vahid , Grisdale Cameron J. , Calli Kristina , Martell Sally , Reisle Caralyn , Lillico-Ouachour Amanda , Lewis M.E. Suzanne , Jones Steven J.M.
Published: December 2024

Autism spectrum disorder (ASD) is an increasingly recognized childhood developmental disorder. Despite extensive study, causal variants and molecular diagnosis remain elusive. There is both heterogeneity of the phenotype, as well as the genetic landscape associated with phenotype, which includes both inherited and de novo mutations. Currently, diagnosis is complex and behaviourally based, oftentimes occurring years after the ideal 1–2 years of age. Structural variants (SVs) are large and sometimes complex genomic variants that are likely underrepresented contributors to ASD due to the limitations of short-read DNA sequencing, such as alignment in repetitive regions and regions with GC bias. Here, we performed long-read sequencing (LRS) on four individuals with autism spectrum disorder to delineate SV complexity and determine precise breakpoints for SVs, which was not possible with short-read whole-genome sequencing (SRS). We use LRS to interrogate the methylation pattern associated with the SVs and phase the SV haplotypes to further clarify their contribution to disorder. LRS allows insight into the genome and methylome that allow us to uncover variant complexity and contribution that was previously unseen with SRS. Ultimately, this furthers precision diagnosis and contributes to individualized treatment for affected individuals and their families within the clinic.
Study on Predicting College Students’ Career Inclinations and Providing Personalized Suggestions Based on Neural Networks
Authors: Jin Xu
Published: December 2024

Personalized training is necessary to meet individual differences in educational attainment, opinions, job choices, and confidence since college enrollment is growing increasingly varied. To put this into practice, it will be essential to gather and assess data from a range of students, use institutional data to perform resource-effective investigations, and take into account the career prospects of learners while developing accurate teaching methods. This research shows a novel emperor penguin search-assisted artificial neural network (EPS-ANN) approach for effectively predicting college students’ career inclinations. This work uses a dataset of student academic concerts for training the proposed technique. The dataset is first preprocessed to develop the features evaluation. To extract the significant features from the normalized data, linear discriminant analysis, LDA, is used. The suggested method is used to further process these important variables to get good predictive performance. The parameters of the ANN are improved by using the EPS optimization process. The suggested approach is tested on the Python platform and examined using several metrics. Additionally, a comparison of the suggested and current approaches is done. In summary, the EPS-ANN approach outperformed other techniques in forecasting the career preferences of college students.
Design of Student Behavior Analysis and Management System Based on Deep Learning
Authors: Zou Xiaopeng
Published: December 2024

The purpose of the research is to utilize Deep Learning (DL) algorithms to analyze student behavior and learning management systems, to address the growing need for effective monitoring and intervention strategies in educational environments. This study proposed a novel parallel-computing fruit fly-optimized adjustable recurrent neural network (PFFO-ARNN) to analyze student online temporal behaviors for the early prediction of course performance. For this research, student behavior data was collected from the learning management system used in the college. The data is preprocessed using tokenization and the features are extracted using word2vec to convert words into numerical vectors from preprocessed data. We evaluate the prediction performance of PFFO-ARNN using various parameters and compare it to other conventional techniques. The findings show that early identification of students at risk with a greater level of prediction Accuracy, Precision, Recall, and F1-score was achieved by employing the PFFO-ARNN. Furthermore, compared to other conventional techniques, the PFFO-ARNN approach demonstrated greater generalization and better prediction performance.
Paeoniflorin Attenuates Oxidative Stress and Inflammation in Parkinson’s Disease by Activating the HSF1-NRF1 Axis
Authors: Gong Xin , Tan Zhijian , Xu Henghui , Jiang Xu , Chen Lei
Published: December 2024

This study is to explore the effects of paeoniflorin (PF) on oxidative stress (OS) and inflammation in Parkinson’s disease (PD) via the HSF1–NRF1 axis. SH-SY5Y cells were pretreated with PF and induced with α-synuclein preformed fibrils (PFF), followed by gain- and loss-of-function assays. Afterward, detection was conducted on cell viability, mitochondrial membrane potential ([Formula: see text]m), and reactive oxygen species (ROS), cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) levels. The binding of HSF1 to NRF1 promoter was evaluated. HSF1 and NRF1 expression was examined. Lastly, PD mouse models were established, followed by observation of the behavioral features of mice. Apoptosis; cleaved-Caspase 3, cleaved-Caspase 8, repulsive guidance molecule A (RGMa), GAP-43, and brain-derived neurotrophic factor (BDNF) expression; and superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), catalase (CAT), tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-6, and IL-10 levels were determined in mice and cells. HSF1 and NRF1 were downregulated, and HSF1 promoted NRF1 transcription and PF dose-dependently augmented HSF1 and NRF1 expression. PF dose-dependently reduced RGMa expression, ROS, MDA, TNF-α, IL-2, and IL-6 levels; mitigated apoptosis; and lowered cleaved-Caspase 3, cleaved-Caspase 8, COX-2, and iNOS expression while improving cell viability; increasing [Formula: see text]m, GAP-43, and BDNF expression; and raising SOD, GSH-Px, CAT, and IL-10 levels in PFF-induced SH-SY5Y cells. These effects were neutralized by HSF1 knockdown. In conclusion, PF dose-dependently activated the HSF1–NRF1 axis and alleviated OS and inflammation in PFF-treated mice, thereby impeding PD progression in mice.
Does running speed affect the performance improvements experienced by elite distance runners wearing advanced footwear technology spikes?
Authors: Needles Bradley J. , Grabowski Alena M.
Published: December 2024

After accounting for historical race time trends, average race times from the top 100 elite male and female athletes competing in the 800-m to 10,000-m events have improved since the introduction of advanced footwear technology spikes. However, the percentage performance improvement is smaller at faster average running speeds. Thus, future research is warranted to determine the interaction of footwear compliance, running speed, and performance for elite runners.
Sacituzumab Govitecan in Patients with Relapsed/Refractory Advanced Head and Neck Squamous Cell Carcinoma: Results from the Phase II TROPiCS-03 Basket Study
Authors: Michel Loren , Jimeno Antonio , Sukari Ammar , Beck J. Thaddeus , Chiu Joanne , Ahern Elizabeth , Hilton John , Even Caroline , Zanetta Sylvie , Mekan Sabeen , Patel Jilpa , Wu Tia , Dumbrava Ecaterina E.
Published: December 2024

Purpose:

Treatment options for advanced head and neck squamous cell carcinoma (HNSCC) previously treated with platinum-based chemotherapy and a PD-1 inhibitor are limited. Trophoblast cell-surface antigen 2 (Trop-2) is highly expressed in HNSCC. Sacituzumab govitecan (SG) is a Trop-2–directed antibody-drug conjugate approved for patients with certain previously treated solid tumors.

Patients and Methods:

TROPiCS-03 (NCT03964727) is an open-label, multicohort, phase II study evaluating SG in advanced solid tumors, including HNSCC. Adults with locally advanced or metastatic HNSCC that progressed following platinum-based chemotherapy and anti–PD-(L)1 therapy [given sequentially (either order) or in combination] were administered SG 10 mg/kg on days 1 and 8 of a 21-day cycle. The primary endpoint was the investigator-assessed objective response rate. Secondary endpoints included duration of response, clinical benefit rate, progression-free survival, overall survival, and safety.

Results:

Patients (N = 43) received a median of 3 (range, 2–9) prior anticancer regimens. The objective response rate was 16% [95% confidence interval (CI), 7%–31%], with seven confirmed partial responses. The clinical benefit rate was 28% (95% CI, 15%–44%). The median (95% CI) duration of response, progression-free survival, and overall survival were 4.2 (2.6–not reached), 4.1 (2.6–5.8), and 9.0 (7.1–10.5) months, respectively. The most common treatment-emergent adverse events (TEAE) were diarrhea (47%), nausea (47%), and neutropenia (47%). Grade ≥3 TEAE occurred in 58% of patients. Three patients died from TEAE, with one event (septic shock) considered related to SG.

Conclusions:

These data demonstrate the clinical potential of Trop-2–directed therapy in managing heavily pretreated patients with advanced HNSCC.
Mathematical Modeling Predicts Optimal Immune Checkpoint Inhibitor and Radiotherapy Combinations and Timing of Administration
Authors: Sakai Shunsuke A. , Saeki Koichi , Chi SungGi , Hamaya Yamato , Du Junyan , Nakamura Masaki , Hojo Hidehiro , Kojima Takashi , Nakamura Yoshiaki , Bando Hideaki , Kojima Motohiro , Suzuki Ayako , Suzuki Yutaka , Akimoto Tetsuo , Tsuchihara Katsuya , Haeno Hiroshi , Yamashita Riu , Kageyama Shun-Ichiro
Published: December 2024

Radiotherapy (RT) combined with immune checkpoint inhibitor (ICI) therapy has attracted substantial attention due to its potential to improve outcomes for patients with several types of cancer. However, the optimal administration timepoints and drug combinations remain unclear because the mechanisms underlying RT-induced changes in immune checkpoint molecule expression and interaction with their ligand(s) remain unclear. In this study, we demonstrated the dynamics of lymphocyte-mediated molecular interactions in tissue samples from patients with esophageal cancer throughout RT schedules. Single-cell RNA sequencing and spatial transcriptomic analyses were performed to investigate the dynamics of these interactions. The biological signal in lymphocytes transitioned from innate to adaptive immune reaction, with increases in ligand–receptor interactions, such as PD-1–PD-L1, CTLA4–CD80/86, and TIGIT–PVR interactions. A mathematical model was constructed to predict the efficacy of five types of ICIs when administered at four different timepoints. The model suggested that concurrent anti–PD-1/PD-L1 therapy or concurrent/adjuvant anti-CTLA4/TIGIT therapy would exert a maximal effect with RT. This study provides rationale for clinical trials of RT combined with defined ICI therapy, and these findings will support future studies to search for more effective targets and timing of therapy administration.
¿Des-víos de la familia en la formación de los hijos e hijas? Nuevos perfiles, funciones constantes
Authors: Páez-Martínez Ruth Milena
Published: December 2024

(analítico): Como campo de estudio, la familia poco ha sido abordada desde la pedagogía, y su función educadora se ha delegado a instancias ajenas a ésta. El propósito del rastreo al concepto familia en diversas disciplinas respondió a la necesidad de comprender su complejidad y posibilidades educativas, y de elaborar unos instrumentos de recolección para la entrevista a ocho grupos focales de familias rurales de distintas regiones de Colombia. Esta investigación cualitativa de enfoque fenomenológico-hermenéutico, permitió hallar que la familia en general ha variado y desviado sus roles de formación a los hijos e hijas por circunstancias externas a ésta y, en consecuencia, funciones antropológicas como la acogida no siempre resultan realizables.
Ahorro infantil: "Chispitasâ€-Estrategia para combatir la pobreza, Fundación Ayú, Oaxaca, México
Authors: Arcos-Medina Guadalupe , Zapata-Martelo Emma , Hernández-Romero Oliverio
Published: December 2024

(analítico): En esta investigación analizamos cómo la estrategia de combate a la pobreza de la Fundación Ayú, influye en el hábito del ahorro de los niños y niñas mixtecos de Oaxaca -los "Chispitasâ€-, con datos obtenidos de noviembre de 2013 a julio de 2014. Realizamos un taller participativo y entrevistas semiestructuradas, aplicando un cuestionario a 42 niños y niñas de diez años de edad promedio, y antigüedad como ahorradores de entre tres y siete años. El perfil socioeconómico familiar corresponde mayormente a hogares campesinos; las razones para ahorrar son la educación, el futuro y las emergencias, siendo las madres quienes mayor influencia tienen en este hábito. Participar en las cajas visibiliza a los niños y niñas en la localidad y los inicia en la inclusión social y financiera.
Diagnósticos psiquiátricos infantiles, biomedicalización y DSM: ¿hacia una nueva (a) normalidad?
Authors: Bianchi Eugenia
Published: December 2024

(analítico): Presento resultados de una investigación postdoctoral que aborda el análisis de las transformaciones recientes en los diagnósticos en salud mental infantil, a través del estudio de dos categorías: TDAH (Trastorno por Déficit de Atención e Hiperactividad) y TEA (Trastorno del Espectro Autista).Empleando métodos analítico-interpretativos sobre bibliografía específica, recupero y sistematizo tópicos trabajados desde perspectivas de la medicalización y la biomedicalización, y estudios sobre el riesgo en salud mental, para el análisis de las tipificaciones psiquiátricas mencionadas.Como un aporte a estos campos, desarrollo la hipótesis según la cual las reformulaciones acaecidas en el manual de clasificación psiquiátrica DSM-5 en el TDAH y TEA, pueden entenderse a la luz de las características más amplias de los procesos de medicalización y biomedicalización que recaen con énfasis en las infancias.
"Mi piel es un lienzoâ€. Sentidos de la Modificación Corporal en Jóvenes de la Ciudad de Cali
Authors: Pabón-Chaves Ana Sofía , Hurtado-Herrera Deibar René
Published: December 2024

(analítico): En el presente artículo damos cuenta de una investigación que tuvo como objetivo comprender los sentidos que tienen las prácticas de modificación corporal en jóvenes de la ciudad de Cali. Para el desarrollo del proyecto optamos por usar como metodología la Teoría fundada. El trabajo nos permite ver a las personas jóvenes como sujetos activos, que se apropian de sus cuerpos para transformarlos, para afirmarse en la diferencia y en la singularidad, en medio de contextos sociales y de consumo que pretenden homogeneizarlos. Concluimos entonces que en las prácticas de modificación corporal se configuran y materializan otras corporeidades en los mundos de la vida juveniles. Dichas corporeidades están en sintonía con unas subjetividades alterdirigidas que son convocadas permanentemente a ser expuestas.
El self adolescente desde la perspectiva contextual: pobreza, viviendas sociales, apoyo parental y participación
Authors: Silva Carmen , Martínez-Guzmán Loreto
Published: December 2024

(descriptive): This topical review offers a descriptive reflection within a contextual framework in relation to the probable effects of poverty and public housing on the adolescent self and adolescent identity. The author hypothesizes that the lack of opportunities to channel the interests of adolescent youth, as well as the social segregation and stigmatization that they suffer from, have negative effects on their aspirations, goals and plans for realizing their aspirations in accordance with mainstream social standards. Self-representation will be affected by socio-spatial stigmatization in case of unfavorable comparisons with social groups that have higher status. The negative effects of living in a deficient neighborhood can be mitigated by parental practices and social participation spaces that contribute to the construction of positive identities. This topic is relevant as a contribution to contextual self theory and public policy.
Key words: Adolescence, self, identity, public housing, parental support (Thesaurus Word Reference.com).
Entre el juego y la agresión: Normas y reglas del evento comunicativo lúdico en un contexto escolar
Authors: Guarín-García Luisa Fernanda , Castellanos-Obregón Juan Manuel
Published: December 2024

(analytical): This research aims to understand communicative aggression among students in the fourth grade. It is focused on an analysis of assault as a type of a communicative event that takes place through norms related to interaction and linguistic interpretation (verbal and nonverbal), which are learnt and developed within communities with specific languages. Through developing an extensive ethnography of the classroom, the authors conducted an analysis of communicative actions, especially during play. The interaction and interpretation norms in place during school and play based communicative events to identify the articulation processes of the statements interpreted as aggressive by the children. The results show that in the communicative dimension of play in school aggressions can occur due to the use of communicative rules and norms by participants that are developed in the cultural setting in which they grow and interact. The set of communicative competencies that are learnt are often used to legitimize aggressive actors or interaction in an implicit manner, and are included as part of their daily experience of school.
Key words: Communicative violence [1016], school [288], ethnography of speaking [439], rule [912], norm [456], game [133], interaction [80], communication [234] (Unesco Social Science Thesaurus).
Talleres socioeducativos en infancia desde un enfoque situado
Authors: Guerrero Patricia , Aguirre Carolina , Besser Cecilia , Morales Miguel , Salinas Javiera , Zamora Macarena
Published: December 2024

(descriptive): The following study consists of examining a practical group intervention with children called "social-educational workshopsâ€ that use a critical perspective. These workshops focused on different psychology-related areas as a way of giving children the power of being listened to, considering them as subjects of rights. The methodology of the study involved a systematic review of materials, reports and interviews with professionals over a period of two years,illustrating the contributions and the tensions involved in working with children. The results show the sustainability of these workshops based on affective relationships, the adaptability of the workshops to participants' needs, their inclusive nature, but also the complexities of the application of these kinds of work procedures.
Key words: Childhood, group dynamics, psychosocial intervention, psychological theories (MeSH Thesaurus).
Condición física y su vinculación con el rendimiento académico en estudiantes de Chile
Authors: Navarro-Aburto Braulio , Díaz-Bustos Erick , Muñoz-Navarro Sergio , Pérez-Jiménez Jeanette
Published: December 2024

(analítico): Nuestro objetivo en este estudio fue determinar la asociación entre el logro académico en matemáticas y las variables de la condición física. Diseñamos un estudio de tipo cuantitativo no experimental a partir de las bases de datos de la prueba Simce 2011, para estudiantes de 8° básico de Chile. La muestra que seleccionamos fue de 18.363 estudiantes. Todas las variables de la condición física mostraron asociaciones significativas con la variable rendimiento académico en matemáticas, siendo la variable potencia muscular asociada al test de abdominales la que mostró las mayores puntuaciones. Los resultados indican el rol relevante de la actividad física en el rendimiento académico. Lo anterior hace necesario generar una nueva mirada respecto de la actividad física, que permita valorar su importancia en la producción de aprendizajes y logros académicos.
Circulação de conhecimento e práticas médico-cirúrgicas entre Brasil e Portugal no período setecentista
Authors: Palma Monique
Published: December 2024

As relações científicas entre o Brasil e Portugal intensificaram-se no século XVIII, com resultados expressos na abordagem médica portuguesa em diálogo com as práticas médicas autóctones. Nesse sentido, este trabalho tem por objetivo estudar a circulação do conhecimento médico-cirúrgico português no Brasil de setecentos, a partir de documentos referentes aos cirurgiões que exemplificam a circulação de conhecimentos entre o Brasil e Portugal, à época. Pretende-se assim comparar os itens de utilidade prática necessários aos cirurgiões referidos na lista de itens de botica que está num documento manuscrito, datado de 1780, existente no Arquivo Histórico Ultramarino (AHU) com o título de Sobre o armazenamento de pólvora e mais apetrechos vindos do Reino, a bordo da charrua “Águia”, e de caixas de botica e instrumentos de cirurgia necessários para a Expedição das Demarcações de Limites territoriais na capitania do Rio Negro. Nesse manuscrito, foram identificados 140 produtos enviados de Portugal para a América portuguesa, para uso na prática médico-cirúrgica, que analisaremos com o Erário Mineral, um tratado médico-cirúrgico do cirurgião Luís Gomes Ferreira, escrito em língua portuguesa, sobre a experiência prática do cirurgião, em terras brasílicas, publicado em 1735.
Participação popular e formação de cidades no período colonial: a "Junta geral” de moradores de 1711 e a singularidade urbana de Ouro Preto
Authors: Bastos Rodrigo Almeida
Published: December 2024

The goal is to reinterpret the foundation of Ouro Preto, Minas Gerais, in the 18th century. The most important deliberations of this settlement resulted from a “General council” of residents convened by the governor, Antonio de Albuquerque Coelho de Carvalho on July 8th, 1711. Several urbanistic decisions were taken in this meeting and the proposal is interpret in an unprecedented way the documents that highlight their relevance. The solution collectively found by the general council of residents not only transgressed the royal order that guided its creation to take place in a certain way and in a certain place, but also made resolutions that determined the urban singularity of the city, which is recognized, by many scholars, as one of the most significant in the Portuguese-Brazilian universe.
Dogs and cats run over in an urban area: analysis of the costs generated, risk areas, and other aspects
Authors: Rocha Yasmin da Silva Gonçalves da , Gomes Luana Ribeiro , Brugnerotto Michele , Garcia Rita de Cassia Maria
Published: December 2024

Cães e gatos soltos em vias públicas podem ter tutores, pertencer à comunidade ou estar abandonados. A ausência de políticas públicas eficazes para o manejo populacional de cães e gatos (MPCG) contribui para a presença de animais nas vias, aumentando o risco de acidentes e atropelamentos. Não há estudos disponíveis que identifiquem as áreas de maior risco para atropelamentos, nem se conhecem os custos envolvidos na remoção e no destino adequado dos cadáveres. O índice de atropelamentos de animais nos municípios pode ser utilizado como um indicador para monitorar a implementação de medidas de guarda responsável e avaliar a efetividade das estratégias adotadas no programa de manejo populacional de cães e gatos (MPCG). O objetivo deste estudo foi analisar os atropelamentos de cães e gatos e os custos envolvidos no Município de Pinhais, Paraná, Brasil, em comparação com outros custos de manejo populacional de cães e gatos. A Prefeitura forneceu dados referentes ao período de janeiro de 2016 a dezembro de 2017 sobre o recolhimento de cadáveres de animais das vias públicas, que incluíram: custos envolvidos; número de animais atropelados por espécie; e endereço dos atropelamentos para mapear as ocorrências. Durante este período foram recolhidos 199 cães e 32 gatos mortos por atropelamento. O serviço de coleta, transporte e destinação de cadáveres de animais teve um custo médio mensal de R$ 20.325,19 (US$ 3,792) e o valor gasto por quilo de peso do animal foi de R$14,83/kg (US$ 2.76). Os atropelamentos ocorreram com maior frequência em regiões com menor nível socioeconômico (>90%) e estradas não rápidas (62,3%), consideradas, portanto, regiões com maior propensão a agravos.
Seroprevalence of anti-Ehrlichia sp. and Anaplasma sp. antibodies in dogs sheltered in 2022 in Maceió, Alagoas
Authors: Oliveira Aline dos Santos , Graboschii Amanda Caroline Gomes , Silva Keityane de Oliveira e , Melo Mônica , Bittencourt Thereza Cristina Borio dos Santos Calmon de , Escodro Pierre Barnabé
Published: December 2024

Hemoparasitoses are diseases that have many cases in the medical-veterinary routine, mainly affecting dogs. Main hemoparasitoses include canine monocytic ehrlichiosis (CME) and canine thrombocytic anaplasmosis (CTA). The present study aimed to carry out an analysis regarding cases of ehrlichiosis and anaplasmosis and the presence of antibodies against Ehrlichia sp. and Anaplasma sp. in dogs treated by the Integra Animal Project, observing epidemiological data, such as age group, sex, and presence of ticks. Blood count, epidemiological profile, and 4DXs plus test were analyzed from 102 dogs taken in by the project. A descriptive analysis was carried out regarding the collected data, focusing on data such as age group (in months), presence of Rhipicephalus sanguineus ticks, erythrogram, leukogram, and animals positive and negative for ehrlichiosis and anaplasmosis. Out of the 102 dogs, 48 (47%) of the animals had antibodies to Ehrlichia canis., and 23 (22.5%) had antibodies to Anaplasma platys. With these results, it was possible to analyze the hematological evidence in positive and negative dogs and draw conclusions from the study’s findings. Notably, among the positive animals, only 4 (4%) had the presence of ticks and no clinical manifestations, while 32 (31.7%) showed normocytic normochromic anemia and no significant changes in leukogram variables. There was no statistical difference between genders and the presence of ticks, with substantial change only being noticeable in elderly dogs due to the prevalence of antibodies in the animal’s body. It is concluded that the 4DX plus test effectively detects antibodies for these infections. However, it requires direct correlation with laboratory tests, contributing significantly to the diagnosis and treatment of canine ehrlichiosis and anaplasmosis.
O Cenário Pandêmico no Brasil: luta pela vida e o desmonte das políticas públicas
Authors: Pereira Junior Luciano Aparecido , Martins João Pedro Pereira , Tasso Thercius Oliveira , Beretta Regina Celia de Souza
Published: December 2024

La pandemia provocada por el coronavirus ha dejado al descubierto las numerosas vulnerabilidades sociales que ya existían, como el hambre, el desempleo, la falta de acceso a los recursos tecnológicos y la violencia doméstica. Los estudiantes se vieron afectados por una educación pública alejada y sin preparación, y la crisis de la sanidad pública se amplió con la falta de suministros, camas y la exposición de los profesionales de la salud y otras áreas al peligro. Durante este acontecimiento se perdieron varias vidas y se plantearon muchas preguntas. En este escenario, la salud mental de las personas que se enfrentaban al aislamiento, el distanciamiento social y la cuarentena se vio sacudida y muchas personas enfermaron en sus casas. Además, los profesionales que se pusieron en riesgo se encontraron en una lucha por la vida de las personas y el bienestar de sus familias, exigiendo también atención psicológica. La promoción de la salud, con el cuidado como uno de sus fundamentos, se ha convertido en una de las herramientas para el cuidado de los demás y el autocuidado, incluso en sus hogares. Así, este período pandémico se convirtió en una época de reinvenciones, sin embargo, acentuó los males sociales y la precariedad del sistema de salud pública en Brasil, demostrando que la inaplicabilidad de las políticas públicas existentes se mantiene y que incluso en esta época de calamidad pública, el desmantelamiento de los sistemas y servicios públicos se ha ampliado
As Cinco Estrelas de Neli Aparecida de Mello-Théry
Authors: Sampaio Mateus de Almeida Prado
Published: December 2024

Este texto visa analisar criticamente a obra de Neli Aparecida de Mello-Théry e ao mesmo tempo prestar-lhe uma singela homenagem. São avaliados com maior atenção, quase que em formato de resenha, os cinco trabalhos científicos escolhidos pela autora para comporem o hall de publicações mais significativas de sua carreira. Estes foram marcados com uma estrela de destaque em seu currículo CNPq/Lattes online. Inicialmente é traçada uma retrospectiva profissional da autora para na sequencia abordar-se as seguintes obras destacadas: L'État brésilien et l'environnement en Amazonie: évolutions, contradictions et conflits (2003); Políticas territoriais na Amazônia (2006); Atlas do trabalho escravo no Brasil (2012); Politiques environnementales brésiliennes: intentions et réalités (2017) e Disparidades e dinâmicas do território (2018). Enquanto características comuns à todas essas publicações estão as preocupações ambientais e o papel das políticas públicas no delineamento dos rumos dados ao desenvolvimento territorial do país, notadamente na Amazônia: temas profundos, abrangentes, prementes e necessários.
Néstor Perlongher como lector, difusor y crítico temprano del posestructuralismo francés en Latinoamérica.
Authors: Alarcón Jorge Ignacio
Published: December 2024

This article analyzes the citric production of the poet, essayist, and urban anthropologist, Néstor Perlongher. Our analytical perspective focuses on his relationship with theoretical sources from French post-structuralism. His critical work stands out not only for being unique in translating and disseminating Deleuze's work in Argentina, but also for providing a relevant critical theoretical framework for neobarroso poetic works that until then lacked a consistent framework of analysis. We are interested in his concomitant and critical attitude towards these sources and in the processes of updating and adaptation that he made of these based on the Latin American perspective of literary and anthropological studies.
Sentidos sobre o passado: uma análise comparativa do espanhol e do português
Authors: Campos Rodrigo da Silva , Vargens Dayala Paiva de Medeiros
Published: December 2024

This study aims to perform a brief comparative analysis of the past perfect tense of the indicative mood in the Portuguese and Spanish languages, focusing on the nuances expressed by this (these) verb tense(s) in contrast with the meanings that derive from possible translations into Portuguese. To support this analysis, we have mapped, among other authors, definitions found in the works of Bosque (2009), Matte Bon (1998), Gómez Torrego (2002); and Charaudeau; Darbord; Pottier (1994) concerning verb tenses in Spanish, and Azeredo (2010), Cunha; Cintra (1992), and Bechara (2009) with respect to the study of tenses in Portuguese. In this article, we also address the notion of temporal deixis and seek to reflect on the role of grammatical study in linguistic education.
El castillo de arena que aún resiste. Afectos y exilio en Su fuego en la tibieza (1981) de Alberto Szpunberg
Authors: Luján María Luján Travela
Published: December 2024

El poeta y militante revolucionario argentino Alberto Szpunberg (1940-2020) publica en Barcelona, en el año 1981, Su fuego en la tibieza, tras exiliarse en 1977. Con este libro, se da inicio a un segundo ciclo de su obra, en la que su condición exilar será central en su escritura. En este trabajo analizaremos el modo en el que los afectos participan de el trabajo del escritor, concentrándonos en los poemas de “Exilio en el Masnou”. En estos textos, la dimensión afectiva es capaz de ofrecer una clave de lectura al configurar un escenario en el que conviven la melancolía y la derrota con el optimismo y el cariño.
O percurso de Criação do romance O braço direito de Otto Lara Resende: um estudo genético das notas prévias vinculadas à segunda edição do romance
Authors: Nunes Flavia Maria de Oliveira
Published: December 2024

O trabalho visa à edição e compreensão da utilização de notas prévias vinculadas à segunda edição do romance O braço direito, de Otto Lara Resende.
Acaso como tendência: o projeto poético de Milton Montenegro
Authors: Gonçalves Maria Gorete Dadalto
Published: December 2024

Este artigo traz a pesquisa sobre o projeto poético de Milton Montenegro, apresentada durante o VIII Congresso Internacional da APML, realizado em 2005, em São Paulo.
Informação estética: processos de construção de formas na criação
Authors: Panichi Edina Regina
Published: December 2024

Este artigo traz a pesquisa sobre processos utilizados por Pedro Nava para a elaboração de seus textos, apresentada durante o VIII Congresso Internacional da APML, realizado em 2005, em São Paulo.
O grande encontro: uma reflexão sobre o diálogo entre o verbal e o visual em Lampião e Lancelote
Authors: Medeiros Juliana Pádua Silva
Published: December 2024

Este artigo, a partir do conceito calviniano de multiplicidade, propõe-se a analisar o livro Lampião e Lancelote, de Fernando Vilela, publicado em 2007 pela Cosac Naify, buscando abordar o grande encontro entre tempos, espaços, personagens, culturas, gêneros, artes e técnicas por meio do diálogo entre o verbal e o visual. Sob a perspectiva de um “sistema de sistemas”, em que cada um condiciona os demais e é condicionado por eles, o presente texto debruça-se sobre a cartografia da referida obra destinada à infância (espécie de mapa hipertextual), apresentando um itinerário de leitura (caminhos possíveis de interpretação), de modo a refletir como o leitor abre links e mais links, percorrendo a rede de significados que é tecida no imbricamento de linguagens.
Metalinguagem em processo: a influência das verbalizações de termos metalinguísticos pelo professor na construção de narrativas ficcionais de alunos recém-alfabetizados
Authors: Silva Maria Auxiliadora da , Felipeto Sônia Cristina Simões , Calil Eduardo
Published: December 2024

Este estudo investiga o uso de termos linguísticos que emergem durante o processo de produção textual em sala de aula, envolvendo alunos do primeiro ano do ensino fundamental em uma situação de escrita colaborativa. A discussão se concentra na verbalização de termos linguísticos durante as orientações da professora para a construção de narrativas ficcionais. Nosso objetivo é compreender como os termos linguísticos verbalizados na orientação da construção textual em duplas influenciam a construção das narrativas pelos alunos, com o apoio da Linguística enunciativa benvenistiana e da Genética de Textos, respaldados pela Psicologia Cognitiva. Por meio do registro fílmico sincronizado do processo de composição textual e do acompanhamento do diálogo espontâneo realizado pelos alunos com o Sistema Ramos, analisamos as verbalizações de termos linguísticos dos alunos enquanto negociam sobre sua escrita e como as interações promovidas pela professora podem facilitar revisões em pontos de tensão durante a construção da narrativa. As análises mostram que as verbalizações da professora ressaltam as reflexões metalinguísticas formuladas pelos alunos ao longo do processo de produção textual.
Introdução aos materiais preparatórios de José Saramago
Authors: Vecchio Daniel
Published: December 2024

In this study, we demonstrate how José Saramago's literary work encompasses the process of conception, research and realization of telling a story, making it exemplary and fundamental to the field of genetic criticism. To this end, we will analyze briefly how Saramago's archive contributes to a better understanding of the genesis of his most prized fiction. The José Saramago Foundation's successive donations to the writer's archive, which is in the National Library of Portugal, allows a significant critical renewal of his works, as knowledge about his archive increases, contradicting those who think that wish to say something new about his already much commented literature is the same as invent the wheel again. Finally, we will see that the genetic approach to Saramago's works points to a typology of representations that situate and clarify the specific relationship between his narrative and the various types of sources consulted by the author during the writing process. Only by identifying these specific documentary relationships will we effectively understand the creative phases of Saramago's texts, exploring new comparisons and new meanings.
Decreased Adipose Lipid Turnover Associates With Cardiometabolic Risk and the Metabolic Syndrome
Authors: Andersson Daniel P. , Arner Peter
Published: December 2024

BACKGROUND:

Disturbed white adipose tissue function is important for cardiometabolic risk and metabolic syndrome (MetS). Whether this involves adipose lipid turnover (lipolysis and synthesis of triglycerides) is unknown and was presently investigated in subcutaneous adipose tissue, the body’s largest fat depot.

METHODS:

In cross-sectional studies in 78 subjects, adipose lipid age, representing overall lipid turnover (mobilization and storage), and lipid storage capacity were assessed by the incorporation of atmospheric
14
C into adipose lipids. Adipose lipid age from an algorithm of adipocyte lipolysis and clinical parameters was also determined in 185 subjects. Adult Treatment Panel III (ATPIII) scoring defined MetS (scores 3–5) or healthy (score 0). ANOVA or ANCOVA and
t
test were used for statistical comparison. Because there was no method interaction to determine lipid age, the 2 groups were combined.

RESULTS:

Lipid age increased by incremental ATPIII score (F=42;
P
<0.0001) and was 2-fold advanced in MetS (t=11.3;
P
<0.0001). The correlation with lipid age was independent of age, sex, body mass index, waist-to-hip ratio, sedentary lifestyle, absence of obesity, and adipose insulin resistance (F=10.7;
P
<0.0001). Lipid storage capacity was not related to the ATPIII score (F=1.0;
P
=0.44) or MetS (t=−0.9;
P
=0.35). Adipocyte lipolysis activation was decreased in MetS and inversely related to incremental ATPIII score, suggesting that decreased lipid mobilization is the major factor behind high lipid age in these conditions.

CONCLUSIONS:

Despite normal lipid assimilation capacity, abdominal subcutaneous adipose lipid turnover is decreased in MetS and high ATPIII score because of impaired ability to mobilize lipids involving low adipocyte lipolysis activation.
Semaglutide Improves Myocardial Perfusion and Performance in a Large Animal Model of Coronary Artery Disease
Authors: Stone Christopher , Harris Dwight D. , Broadwin Mark , Kanuparthy Meghamsh , Nho Ju-Woo , Yalamanchili Keertana , Hamze Jad , Abid M. Ruhul , Sellke Frank W.
Published: December 2024

BACKGROUND:

Coronary artery disease is the leading cause of death worldwide. It imposes an enormous symptomatic burden on patients, leaving many with residual disease despite optimal procedural therapy and up to one-thirds with debilitating angina amenable neither to procedures, nor to current pharmacological options. Semaglutide (SEM), a GLP-1 (glucagon-like peptide 1) agonist originally approved for management of diabetes, has garnered substantial attention for its capacity to attenuate cardiovascular risk. Although subgroup analyses in patients indicate promise, studies explicitly designed to isolate the impact of SEM on the sequelae of coronary artery disease, independently of comorbid diabetes or obesity, are lacking.

METHODS:

Yorkshire swine (n=17) underwent placement of an ameroid constrictor around the left circumflex coronary artery to induce coronary artery disease. Oral SEM was initiated postoperatively at 1.5 mg and scaled up in 2 weeks to 3 mg in treatment animals (n=8) for a total of 5 weeks, while control animals (n=9) received no drug. All then underwent myocardial harvest with acquisition of perfusion and functional data using microsphere injection and pressure-volume loop catheterization. Immunoblotting, immunohistochemistry, and immunofluorescence were performed on the most ischemic myocardial segments for mechanistic elucidation.

RESULTS:

SEM animals exhibited improved left ventricular ejection fraction, both at rest and during rapid myocardial pacing (both
P
<0.03), accompanied by increased perfusion to the most ischemic myocardial region at rest and during rapid pacing (both
P
<0.03); reduced perivascular and interstitial fibrosis (both
P
<0.03); and apoptosis (
P
=0.008). These changes were associated with increased activation of the endothelial-protective AMPK (AMP-activated protein kinase) pathway (
P
=0.005), coupled with downstream increases in eNOS (endothelial NO synthase;
P
=0.014).

CONCLUSIONS:

This study reveals the capacity of oral SEM to augment cardiac function in the chronically ischemic heart in a highly translational large animal model, likely through AMPK-mediated improvement in endothelial function and perfusion to the ischemic myocardium.
Solving of the long-term question: resurrection of Dinodon yunnanensis Werner, 1922 (Squamata: Colubridae: Lycodon)
Authors: VOGEL GERNOT , LIU SHUO , DAVID PATRICK , NGUYEN TAN VAN
Published: December 2024

We apply an integrative taxonomic approach, including analyses of molecular and morphological data, along with examination of available type materials, to address the longstanding questioned taxonomic status of Dinodon yunnanensis Werner, 1922, currently considered a junior synonym of Lycodon fasciatus (Anderson, 1879). Based on our data, we revalidate Dinodon yunnanensis, under the combination Lycodon yunnanensis (Werner, 1922) comb. nov. According to the new taxonomic status of Lycodon yunnanensis comb. nov, we restrict the distribution of Lycodon fasciatus to Northeastern India, Central Bhutan, Northern and Central Myanmar, Western and Southwestern Yunnan of China, Northwestern Thailand, Northern Laos, and Northwestern Vietnam. We suggest that Lycodon yunnanensis comb. nov should be considered Least Concern (LC) following the IUCN’s Red List categories. Further studies reassessing the populations of the Lycodon fasciatus complex in Xizang of China is required.
A taxonomic study on the genus Prionyx Vander Linden, 1827 (Hymenoptera: Sphecidae: Prionychini). Subgenus Harpactopus F. Smith, 1856
Authors: DANILOV YURIY N. , ODINTSEV OLEG A. , KOBETS ANASTASIA S.
Published: December 2024

The original keys to the species of subgenus Harpactopus F. Smith, 1856 are provided. The following new synonymy has been established: Prionyx globosus (F. Smith, 1856) (=Harpactopus australis de Saussure, 1867), Prionyx radoszkowskyi (Kohl, 1888) (=Sphex guichardi de Beaumont, 1967), Prionyx stschurowskii (Radoszkowski, 1877) (=Sphex sirdariensis Radoszkowski, 1877), and Prionyx subfuscatus (Dahlbom, 1845) (=Prionyx binghami Jha et Farooqi, 1996). Prionyx crudelis (F. Smith) is newly recorded from Afghanistan and Uzbekistan, P. funebris (Berland) from Yemen, P. macula (Fabricius) from Turkey, P. melanotus (F. Morawitz) from Kazakhstan and Uzbekistan, P. persicus (Mocsáry) from Afghanistan, and P. subfuscatus (Dahlbom) from Azerbaijan. The type localities of Sphex stschurowskii Radoszkowski and S. sirdariensis Radoszkowski are updated and corrected.
Endogean and cavernicolous Coleoptera of the Balkans. XXVII. A new species of Mayetia Mulsant et Rey, 1875 (Coleoptera: Staphylinidae: Pselaphinae) from Serbia
Authors: HLAVÁČ PETER , JANÁK JIŘÍ
Published: December 2024

The new species Mayetia serbica sp. nov. is described from the Radan Mountain in southern Serbia. The morphological details as well as the aedeagus is presented. The catalogue of the genus for the Balkan Peninsula with all relevant references is provided.