bluuebunny/crossref_metadata_2025 huggingface dataset:
Plataformas de solução de conflitos nas agências reguladoras e a implantação da resolução n. 358 do conselho nacional de justiça (CNJ)
Authors: Bragança Fernanda , Loss Juliana , Braga Renata
Published: July 2022

Esta pesquisa tem o objetivo de fazer um levantamento dos modelos de plataformas de solução de conflitos utilizados pelas agências reguladoras (AR) federais e analisar o tema à luz da Resolução n. 358 de 2020 do CNJ, que prevê a implantação do sistema informatizado para a resolução de conflitos por meio da conciliação e mediação (SIREC) pelos tribunais brasileiros. O estudo identificou dois modelos de ODR: a constituição de uma plataforma própria, customizada para o setor, como é o caso da ANS e a celebração de termos de cooperação com o consumidor.gov.br. Em que pese essa última opção ser a preferida por grande parte das AR, ela não parece adequada aos requisitos da Resolução n. 358. A metodologia de estudo se baseou em uma revisão bibliográfica e em uma análise dos dados abertos dos relatórios de AR federais, do consumidor.gov.br e do CNJ.
ODR Previdenciária
Authors: Suriani Fernanda
Published: July 2022

O presente artigo trata da possibilidade de se instituir uma plataforma de resolução online de conflitos previdenciários, ou seja, uma ODR Previdenciária. Para tanto, parte-se da revisão bibliográfica e do estudo de dados secundários utilizando-se de fontes empíricas e legislativas visando verificar as vantagens e os desafios da ODR previdenciária para o sistema de justiça. Na primeira parte do trabalho, aborda-se os avanços trazidos pelas ODRs como instrumento de ampliação de acesso à justiça. Em seguida, será tratado o contexto normativo e doutrinário que envolve a solução consensual de conflitos pela Advocacia Pública, bem como os avanços tecnológicos na gestão do contencioso pela Advocacia-Geral da União – AGU. Por fim, serão analisadas as características da litigiosidade previdenciária e os elementos necessários para a instituição de uma ODR previdenciária eficaz.
Influence of Helicobacter pylori Infection on Atherosclerosis Risk Factors in Older People
Authors: Zefenkey Zean
Published: July 2022

Atherosclerosis is a significant cause of mortality from cardiovascular disease. The role of Helicobacter pylori (H. pylori) infection in atherogenesis is debatable. The current study aimed to assess the association between H. pylori infection and some risk factors of atherosclerosis in older people. 180 males and females, apparently healthy, over 60 years old, were examined by Fecal Helicobacter Pylori-Antigen ELISA test for H. pylori infection. Blood pressure, high-density lipoprotein-cholesterol (HDL-cholesterol), low-density lipoprotein-cholesterol (LDL-cholesterol), triglyceride (TG), fasting blood glucose, and body mass index (BMI) were measured for all participants.

The faecal H. pylori antigen-positive group had a lower HDL-cholesterol level and higher levels of LDL-cholesterol, triglyceride, fasting blood glucose, and BMI than the faecal H. pylori antigen-negative group with a statistical difference (P < 0.05). The faecal H. pylori antigen-positive group had 2.4, 2.2, 2.6, 2.5 fold more likely to have increasing in the LDL-cholesterol, triglyceride, BMI, and decreasing in HDL-cholesterol, respectively. This risk became more considerable after adjustment for gender, age, blood pressure, and fasting blood glucose (adjusted odds ratio (AOR)= 3.1, 3.0, 3.3, 3.3), respectively.

The infection by H. pylori in older adults is an independent factor for increasing lipid profile and BMI, which are the key modifying factors for the progress of atherosclerosis.
Sumudu-Decomposition Method to Solve Generalized Hirota-Satsuma Coupled Kdv System
Authors: Azzo Shrooq Mohammed , Manaa Saad A.
Published: July 2022

In this work, we take Adomian Decomposition Method (ADM) and combine it  with Sumudu Transform method (STM). This connection between the two methods is called Sumudu-Decomposition Method (SDM), then use it to solve generalized  Hirota-Satsuma Coupled kdv (H-SC kdv) systems and also we applied the STM, to find the approximate solutions of system one. Then we compare the approximate solutions of the two way with exact solitary solutions. Clarifying the best way through tables and drawings, then discussing the reason for the changes taking place in the roads and which one is closest to the exact solution.
Bounds For the Coefficients of Two New Subclasses of Bi-Univalent Functions
Authors: Abdullah Khalid Ibrahim , Mohammed Nafya H.
Published: July 2022

This article discusses two new subclasses of the bi-univalent functions category ∑ in the open unit disk . The primary goal of the article is to obtain estimations of the coefficients  and for the functions that are within these two new subclasses.
On Cubic Interval Vague Sets and Cubic Interval Vague Topological Spaces
Authors: Haji Arsalan Shareef , Khalaf Alias Barakat
Published: July 2022

advance a modern extension formation of cubic vague sets identified as cubic interval vague sets (CIVSs).  similarly describe the idea of  cubic interval vague sets (ICIVSs)    cubic interval vague sets (ECIVSs) by examples  debate their exciting properties, excluding ICIVSs  ECIVSs  - . Additionally,  show -  ICIVSs (  ECIVSs) necessity not be an ICIVS (or ECIVS).  apply the idea of (CIVS) to topological spaces and present the idea of cubic interval vague topological spaces. Further, we introduce P-cubic interval vague topological space and R-cubic interval vague topological space. We discuss basic properties of cubic interval vague topological space.
ANALYSIS OF THE RELATIONSHIP BETWEEN ANXIETYDEPRESSIVE DISORDERS AND PAIN IN PATIENTS WITH MYOFASCIAL SYNDROME
Authors:   Grodno State Medical University, Grodno, Belarus, Sirytsyna Y. Ch. , Sivakov A. P. ,   Belarusian Medical Academy of Postgraduate Education, Grodno, Belarus
Published: July 2022

Background. Myofascial syndrome (MFS) as a chronic pain syndrome is most often combined with depressive disorders and can mask hidden «somatization» depressions. Recently, more and more data have been accumulated on the effect of anxiety and depressive manifestations on the course of the pain process, which significantly worsen the prognosis of the disease. Objective: To determine the presence and analyze the relationship between anxiety-depressive disorders and pain in MFS in patients with somatoform autonomic dysfunctions. Material and methods. The study involved 50 patients with somatoform autonomic dysfunctions associated with with MFS as well as anxiety and depressive disorders of varying severity. The pain was studied using the VAS scale, anxiety-depressive disorders were assessed according to HADS. To test the significance of differences in the values of quantitative signs the Kruskal-Wallis H-test was used. The relationship between the signs was assessed using correlation analysis. Differences and associations were considered statistically significant at p<0.05. Results. With an increase in the level of pain, the number of patients with clinical manifestations of anxiety and de- pressive symptoms increases. Correlation analysis of the relationship between pain and depressive disorders (r=0.722, ρ=0.721) as well as between pain and anxiety disorders (r=0.665, ρ=0.618) showed a positive close relationship. Conclusions. Signs of anxiety and depressive disorders varying from subclinical to clinically pronounced forms were detected in 60% of patients. We also established a close relationship between anxiety and depressive disorders, which indicates their comorbidity.
NEUROTROFIN (NGF) LEVELS IN ARVI AND COVID-19
Authors:   Grodno State Medical University, Grodno, Belarus, Semenova S. G. , Tsyrkunov V. M. ,   Grodno State Medical University, Grodno, Belarus, Shulika V. R. ,   Grodno State Medical University, Grodno, Belarus, Malyshka N. G. ,   Grodno Regional Hospital of Infectious Diseases, Grodno, Belarus
Published: July 2022

Background. Nerve growth factor (NGF) is expressed in different parts of the respiratory tract and reflects the degree of secretion disorders and airway hyperreactivity in ARVI. Objective. To estimate the diagnostic value of the NGF in ARVI and COVID-19. Material and methods. The study was conducted in two phases (before the pandemic and during the COVID-19 pandemic). A total of 43 children with ARVI and community-acquired pneumonia were observed at the first stage and 160 adult patients with COVID-19 (moderate (M-COVID) and severe (S-COVID) were observed at the second stage. Serum NGF level was estimated using Human NGF (Nerve Growth Factor) ELISA Kit, Fine Test system. Results. Among ARVI in children mono infection prevailed (61.9%) and was represented by hRSV in 23.0% of cases. Аmong mixed forms of ARVI (38.1%) hRV was the leader (87.5%, 7/8), as a co-infection – hRV + hRSV (3/8). NGF expression in children with moderate mono infection was 195.89 (79.27; 256.01), in severe pneumonia – 280.04 (17.73; 725.04), statistical differences were significant p < 0.05. NGF levels in M-COVID and S-COVID were multidirectional and had large level fluctuations within individual groups. A certain pattern was an increase of NGF level in pneumonia associated with ARVI and a decrease of NGF level in pneumonia associated with COVID-19, regardless of severity, in concomitant obesity and diabetes mellitus, in patients on O therapy and hormone treatment, including patients with M-COVID, as well as in patients with signs of respiratory failure (p < 0.05). As respiratory failure and oxygen dependence progressed in S-COVID, the inflammation markers were rising. The proposed ratio represented by C-reactive protein (CRP) and NGF proved to be the most informative test for assessing epithelial dysfunction and disease severity, which was confirmed by the ROC analysis (p < 0.05). Conclusions. NGF score and the CRP/NGF ratio represent additional criteria for assessing severity and predicting the development of an unfavorable outcome due to epithelial dysfunction in the respiratory tract in ARVI and COVID-19.
CHARACTERISTICS OF INDICATORS OF MICROBIOLOGICAL EFFICACY OF ALCOHOL-CONTAINING AGENTS
Authors:   Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Belarus, Miklis N. I. , Burak I. I. ,   Vitebsk State Order of Peoples’ Friendship Medical University, Vitebsk, Belarus
Published: July 2022

The purpose of the research was to study the indicators of microbiological efficacy of compositions of ethyl alcohol 72% with brilliant green 0.01-0.001%, crystalline iodine 0.5-0.1%, chlorhexidine bigluconate 0.5-0.01%. Material and methods. The studies were performed on standard test cultures of Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Proteus mirabilis ATCC 14153, Candida albicans ATCC 10231, as well as on clinical strains of Klebsiella pneumoniae 620, Acinetobacter baumannii 445, isolated from patients of the Vitebsk Regional Clinical Infectious Diseases Hospital, and clinical strains of Klebsiella pneumoniae 1051, Acinetobacter baumannii 886, Staphylococcus aureus 1230, Pseudomonas aeruginosa 1074, isolated from patients of the Vitebsk Regional Clinical Hospital. Results. In the studied alcohol compositions the totalamountofaerobesislessthan 102 CFUper 1 ml, the totalnumber of fungi is less than 10 CFU per 1 ml. Standard and clinical strains of microorganisms are sensitive to compositions of ethyl alcohol 72% with all the studied concentrations of brilliant green, crystalline iodine, chlorhexidine bigluconate, as well as ethyl alcohol 70% and 72% at an exposure of 1 minute in a qualitative suspension test tube method without protein load, in a micromethod on sterile 96-dimple polystyrene plates and in the disk diffusion method. The reduction factor in the quantitative suspension method for all the studied compositions in relation to standard and clinical strains is above 5.0 lg. Conclusions. The results of the study enable to conclude that the developed alcohol compositions have high antimicrobial activity against standard and clinical strains and meet the standard microbiological indicators of the efficacy of disinfectants and antiseptics, and are microbiologically pure and meet the regulatory requirements in terms of microbiological purity. Compositions of ethyl alcohol 72% with brilliant green 0.01%, with crystalline iodine 0.25%, with chlorhexidine bigluconate 0.1% are combined agents with a sufficient synergistic effect and can be recommended as prophylactic antimicrobial agents.
INFLUENCE OF PERIOPERATIVE FACTORS ON THE LEVEL OF CORTISOL IN ANESTHESIA DURING CARDIAC SURGERY
Authors:   Mogilev Regional Clinical Hospital, Mogilev, Belarus, Dudko V. A. ,   Vitebsk State Order of Peoples Friendship Medical University, Vitebsk, Belarus, Klepcha T. I. ,   Mogilev Regional Clinical Hospital, Mogilev, Belarus, Lipnitski A. L. ,   Mogilev Regional Clinical Hospital, Mogilev, Belarus,   Vitebsk State Order of Peoples Friendship Medical University, Vitebsk, Belarus, Sergievich T. V. ,   Mogilev Regional Clinical Hospital, Mogilev, Belarus, Marochkov A. V. ,   Mogilev Regional Clinical Hospital, Mogilev, Belarus,   Vitebsk State Order of Peoples Friendship Medical University, Vitebsk, Belarus
Published: July 2022

Background. In this study the dependence of the level of cortisol on the age of the patient, the presence of disorders of fat metabolism, the dose of muscle relaxant and anesthetic propofol was revealed. Determining the level of cortisol as a component of anesthetic monitoring enables not only to assess the level of perioperative stress, but also to predict the height of the expected stress response. The aim of our study was to determine the influence of perioperative factors on cortisol levels during cardiac surgery. Material and methods. A prospective non-randomized observational study was conducted. The study involved 30 cardiac surgery patients. The age of the patients ranged from 49 to 67 (64 (59; 70)) years, the body mass index was 29.05 (25.56; 33.25) kg/m2. All the patients underwent cardiac surgery under cardiopulmonary bypass. All the patients underwent venous blood sampling to determine the level of cortisol at the following stages: stage 1 - the patient on the operating table, peripheral vein catheterization; Stage 2 - during anesthesia, before connecting to a heart-lung machine; Stage 3 - the end of the operation, suturing the skin; Stage 4 - 1-3 hours after the operation; Stage 5 - 17-20 hours after surgery. Quantitative determination of cortisol in blood serum was carried out by the immunochemical method using the Architect plus i10000sr apparatus (Abbott, USA). Results. The analysis of the obtained data showed that the level of cortisol in the early postoperative period was significantly higher in patients older than 65 (18.8 (10.3; 26.0) µg/dL). The level of cortisol at the second stage of the study was higher in patients with impaired fat metabolism (11.1 (7.1; 15.6) µg/dL). Cortisol levels were significantly lower with higher doses of pipecuronium bromide during anesthesia (5.8 (3.6; 10.5) µg/dL). A significant correlation was found between the dose of propofol at the induction stage and the level of cortisol at stage 4 (R=-0.6; р=0.007). A moderate inverse correlation was established between the level of cortisol and the total dose of fentanyl at the second stage (R=-0.43; p=0.017). Conclusion. Determining the level of cortisol should be a component of anesthetic monitoring when performing cardiac surgery under conditions of cardiopulmonary bypass.
Functional Group Pair Distance based Descriptor for Isomerization in Porous Molecular Framework Materials
Authors: Nurhuda Maryam , Hafidh Yusuf , Perry Carole C. , Addicoat Matthew A.
Published: July 2022

Molecular Framework Materials (MFMs), including Metal Organic Frameworks (MOFs), Covalent Organic Frameworks (COFs) and their discrete equivalents, Metal Organic Polyhedra (MOPs) and Porous Organic Cages (POCs) are porous materials, composed of molecular fragments, bound in one of many topologies. MFMs have a wide variety of potential and realised adsorption applications. In order to design an ideal framework material for a particular application, the composition of molecular fragments is not the only factor, but the arrangement of the those fragments is also important, especially when the fragments (molecular building blocks) are chemically functionalised and lack symmetry. As has been observed in Metal Organic Frameworks, the flexibility and absorption properties may differ greatly when altering the orientation of the building units or changing the position of functional groups. However, although the position of functional group has a great influence on a targeted property, studies on functional group arrangements have only been performed on a small set of MOF structures. In this contribution, we develop a fingerprint/descriptor for optimising functionalised molecular framework structures using machine learning. We begin from the perspective of a molecular framework structure described as a collection of discrete pore shapes. To describe the chemical environment of the pore, we derive a fingerprint based on the occurrence of pairwise distances between functional groups in each pore. We present the possibilities of functional group arrangements in the 14 most common pore shapes, created by ditopic (2-connected) linkers are presented. The method to enumerate and identify possible isomers is explained. Finally the fingerprints of the 14 pore shapes are presented.
Synthesis of Benzofuropyridines and Dibenzofurans by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence
Authors: Clarkson Guy J. , Roesner Stefan
Published: July 2022

An efficient methodology for the synthesis of benzofuropyridines and dibenzofurans from fluoropyridines or fluoroarenes and 2-bromophenyl acetates is reported. This streamlined one-pot procedure consists of a four-step directed ortho-lithiation, zincation, Negishi cross-coupling, and intramolecular nucleophilic substitution, allowing for the facile assembly of a diverse set of fused benzofuro heterocycles.
Rip It, Stitch It, Click It: A Chemist’s Guide to VLP Manipulation
Authors: Herbert Fabian C , Wijesundara Yalini H , Kumari Sneha , Howlett Thomas , Koirala Shailendra , Trashi Orikeda , Trashi Ikeda , Al-Kharji Noora M. , Gassensmith Jeremiah
Published: July 2022

Viruses are some of nature’s most ubiquitous self-assembled molecular containers. Evolutionary pressures have created some incredibly robust, thermally and enzymatically resistant containers to transport delicate genetic information safely. Virus-like particles (VLPs) are human-engineered non-infectious systems that inherit the parent virus’ ability to self-assemble under controlled conditions while being non-infectious. VLPs and plant-based viral nanoparticles are becoming increasingly popular in medicine as their self-assembly properties are exploitable for applications ranging from diagnostic tools to targeted drug delivery. Understanding the basic structure and principles underlying the assembly of higher-order structures has allowed researchers to disassemble (rip it), functionalize (click it), and reassemble (stitch it) these systems on demand. This review focuses on the current toolbox of strategies developed to manipulate these systems by ripping, stitching, and clicking to create new technologies in the biomedical space.
Structure elucidation, biosynthesis, total synthesis and antibacterial in-vivo efficacy of myxobacterial Corramycin
Authors: Couturier Cédric , Groß Sebastian , von Tesmar Alexander , Hoffmann Judith , Deckarm Selina , Fievet Anouchka , Dubarry Nelly , Taillier Thomas , Pöverlein Christoph , Stump Heike , Kurz Michael , Toti Luigi , Haag Richter Sabine , Schummer Dietmar , Sizun Philippe , Hoffmann Michael , Awal Ram Prasad , Zaburannyi Nestor , Harmrolfs Kirsten , Wink Joachim , Lessoud Emilie , Vermat Thierry , Cazals Veronique , Silve Sandra , Bauer Armin , Mourez Michael , Fraisse Laurent , Leroi-Geissler Corinne , Rey Astrid , Versluys Stéphanie , Bacqué Eric , Müller Rolf , Renard Stephane
Published: July 2022

Herein, we describe the myxobacterial natural product Corramycin (1) isolated from Corallococcus coralloides (C. coralloides). Corramycin is a linear peptide containing an unprecedented (2R,3S)  N-methyl-β-hydroxy histidine moiety and exhibiting anti-Gram-negative activity against Escherichia coli. Moreover, we describe the Corramycin biosynthetic gene cluster (BGC) and propose a biosynthesis model involving a 12-modular non-ribosomal peptide synthetase (NRPS)/polyketide synthase (PKS). Bioinformatic analysis of the BGC combined with the development of a total synthesis route allowed for the elucidation of the molecule’s absolute configuration. Furthermore, we show that the uptake of Corramycin in E. coli depends on two transporter systems, SbmA and YejABEF. Importantly, intravenous administration of 30 mg kg 1 of Corramycin in an E. coli mouse infection model resulted in significantly reduced colony forming units (CFU) and in 60 % survival of animals, with no toxic effects observed in vitro or in vivo. Corramycin is thus an intriguing innovative starting point to develop a potent antibacterial drug against hospital acquired infections.
Sequestering and metamorphosis of molecular nitrogen at ambient conditions: role of bonding and back-bonding
Authors: Logdi Ratan , Bag Arijit , Tiwari Ashwani Kumar
Published: July 2022

The optical absorbance behavior of a molecule during the reaction is yet to be explored due to the deficiency in appropriate theoretical and experimental tools. In the present study, the Intrinsic Reaction Coordinate (IRC) trapping methodology is implemented in a new approach to capture the electronic motion during the nitrogen activation reaction by heterocyclic carbenes. This technique acts as a Handycam (Molecular Handycam) to shoot photographs of electrons in the event of a chemical reaction beyond the Born-Oppenheimer approximation. The use of the newly designed molecular Handycam to analyse electron flow at the frontier molecular orbitals during the adduct formation reaction of molecular nitrogen with heterocyclic carbene corroborated that in the carbene −N 2 reaction, carbene operates as a σ −acceptor and π −donor where the bonding and the back bonding processes occur before and after the transition state of the reaction. There is a significant time delay between the bonding and the back bonding process, implying that the bonding back-bonding is not simultaneous for this reaction. These findings ameliorate the DFT-based designing of heterocyclic carbenes to model a congenial catalyst for the sequestering of atmospheric nitrogen and its metamorphosis to ammonia at an ambient and metal-free condition. It is also brought to light that the optical absorption behavior of a molecule may change along the reaction path. Though molecular nitrogen, model carbene and the carbene−N 2 adduct are non-responsive to visible light, an evanescent optical absorbance in the visible region is observed during the chemical reaction.
Colloidal Silicon Quantum Dot-Based Cavity Light-Emitting Diodes with Narrowed and Tunable Electroluminescence
Authors: Cheong I Teng , Mock Josef , Kallergi Maria , Groß Elisabeth , Meldrum Alkiviathes , Rieger Bernhard , Becherer Markus , Veinot Jonathan G. C.
Published: July 2022

Luminescent colloidal silicon quantum dots (SiQDs) have been explored as alternatives to metal-based QDs for light-emitting diodes (LEDs) because of the abundance and biocompatibility of silicon. To date, the broad electroluminescence (EL) bandwidth (> 100 nm) and blue-shifting of EL at high applied voltages of SiQD-LEDs have been outstanding challenges that limited competitive spectral purity and device stability. Herein, we report the fabrication and testing of SiQD-LEDs that incorporate a Fabry-Pérot cavity that exhibit a narrow spectral linewidth as low as ca. 23 nm. The presented devices also provide spectral and visual stability from +4 V to +8 V, as well as spectral tunability.
Age Peculiarities of Marriage Role Expectations and Aspirations of People with Various Personality Maturity Levels
Authors:   Irkutsk State University, Kedyarova E. A. , Monzhievskaya V. V. ,   Irkutsk State University, Uvarova M. Yu. ,   Irkutsk State University, Chernetskaya N. I. ,   Irkutsk State University, Altukhova S. B. ,   Irkutsk State University
Published: July 2022

The paper considers the correlation of marriage role expectations and aspirations with indices of personality maturity of people of three age groups. The study has revealed that young people with high personality maturity level have high role expectations and aspirations in a social sphere. In the middle-aged group subjects with mature personality have high role expectations and aspirations in emotional and psychotherapeutic sphere of family relationships. Subjects with mature personality from the oldest age group showed high role expectations and aspirations in personality self-identification. The study has revealed that people with low personality maturity level have lower level of role expectations in parental relationship sphere than those in other age groups with the same level of personality maturity. In general, people with low personality maturity level in any age group have more non-standard marriage role expectations and aspirations than the ones with high personality maturity level.
COVID-19 no Brasil: tendências, desafios e perspectivas após 18 meses de pandemia
Authors: Siqueira Camila Alves dos Santos , de Freitas Yan Nogueira Leite , Cancela Marianna de Camargo , Carvalho Monica , da Silva Leorik Pereira , Dantas Nielsen Castelo Damasceno , de Souza Dyego Leandro Bezerra
Published: July 2022

Objetivo.

Analisar as tendências de incidência e mortalidade por COVID-19 no Brasil, nas unidades da federação e nas capitais.

Método.

Realizou-se um estudo ecológico com dados de incidência e de mortalidade por COVID-19 referentes ao período de 25 de fevereiro de 2020 (primeiro caso notificado no Brasil) a 31 de julho de 2021. Os dados foram agrupados por mês para cálculo das taxas brutas (por 100 000 habitantes) e avaliação das tendências temporais das unidades da federação e de suas capitais. As modificações significativas nas tendências temporais foram analisadas pelo método de regressão por joinpoint.

Resultados.

Foram identificadas duas ondas de novos casos e óbitos. As unidades da federação com as maiores taxas de incidência foram Amapá, Rio Grande do Norte, Rondônia e Roraima; Amazonas e Rondônia tiveram as maiores taxas de mortalidade. Em geral, as taxas de incidência e mortalidade foram piores na segunda onda. Na primeira onda, a média de meses até o início de uma redução de casos novos foi maior nas capitais, enquanto na segunda onda, o início da redução demorou mais nos estados. Quanto aos óbitos, as capitais necessitaram de menos tempo para apresentar redução tanto na primeira quanto na segunda onda.

Conclusão.

A heterogeneidade regional detectada reforça a ideia de que a incidência e a mortalidade por COVID-19 estão associadas a fatores políticos, geográficos, culturais, sociais e econômicos.
Síntesis de evidencia: Directrices para el diagnóstico y el tratamiento del dengue, el chikunguña y el zika en la Región de las Américas
Authors: Organización Panamericana de la Salud
Published: July 2022

Introducción.

El dengue, el chikunguña y el zika son enfermedades virales que representan una amenaza constante a la salud pública. Las tres arbovirosis pueden producir un cuadro clínico muy similar, lo que representa un desafío para lograr un diagnóstico clínico adecuado y puede conllevar a un inadecuado manejo y generar eventos fatales. La guíaDirectrices para el diagnóstico y el tratamiento del dengue, el chikunguña y el zikaes parte del esfuerzo de la Organización Panamericana de la Salud y los países de la Región de las Américas para evitar los casos graves y la muerte por estas enfermedades, en medio de un complejo panorama epidemiológico donde la presencia de múltiples factores favorece la dinámica de transmisión y ocasiona brotes y epidemias en los países de la Región.

Objetivos.

Sintetizar las recomendaciones incluidas en dicha guía, publicada por la OPS en 2022, con el fin de presentar el adecuado diagnóstico y tratamiento de estas arbovirosis y abordar aspectos sobre la implementación de las recomendaciones.

Métodos.

Se llevó a cabo una síntesis de la guía y sus recomendaciones. Adicionalmente, se realizó una búsqueda sistemática en Pubmed, Lilacs, Health Systems Evidence, Epistemonikos y literatura gris de estudios desarrollados en América Latina y el Caribe con el fin de identificar barreras, facilitadores y estrategias de implementación. Se identificaron y construyeron indicadores de proceso y de resultado de la implementación de las recomendaciones.

Resultados.

Se presentan 12 recomendaciones aplicables a pacientes adultos y pediátricos con sospecha o confirmación de dengue, chikunguña o zika. Se presentan barreras, facilitadores y estrategias para su implementación.

Conclusiones.

Las recomendaciones proveen estrategias para el diagnóstico y el tratamiento oportunos de casos agudos de dengue, chikunguña y zika, así como consideraciones para su implementación.
Experimental investigation and mitigation of chatter in milling machine using magnetorheological fluid
Authors: Nithya N. , D. Sony Priyanka , Kaviraj R. , M. Prasanna Perumal , Jagadheesh M. , S. Naveen Kumar
Published: July 2022

The major problem in all machining operations is chatter which constitutes excessive vibration between tool and the
workpiece. Due to the generation of chatter, tool life, reliability and safety of machining operation will be shortening.
Mechanical smart structures automatically can acknowledge to external loading such as fatigue loads, seismic loads and
shock loads. The application of smart fluid such as Magnetorheological fluid has been the interface between electronic
controls and mechanical system, which provides controllable damping force. One of the important characteristic of MR
fluid is the ability to change from viscous liquid to semi-solids in milliseconds when exposed to a magnetic field.
Experimental investigation has been carried out with different cutting speed, feed rate and depth of cut and varying
input current ranges from 0 to 24 Volts. The input voltage modifies the magnetic field inside the coil of the damper
where chatter mark in the workpiece has been suppressed. The main objective of this work is to recommend MR
damper to suppress vibration and improve surface roughness. The optimum conditions to accomplish better damping
effect for the mitigation of chatter has been identified and 50% of the chatter will be suppressed. The dynamic
response of end milling cutter has been studied with and without the application of MR damper, and roughness
parameters have also been estimated.
Optimization of pintle injector position to control thrust propulsion
Authors: Phanibhaskar Anusuri , Akella Yeswanth , Raghuveer Nemani
Published: July 2022

Pintle nozzle plays a pivotal role in the field of aerospace industry because of the feature of controlling thrust propulsion and
steering. The peculiar nozzle design of the pintle injector helps in proper mixing of propellants and also forces fluids into the
combustion chamber. The position of pintle in rocketry nozzle also contributes in improving efficiency. This paper is
concerned to perform CFD analysis to optimize shape of the pintle head and also by varying different positions of the
pointer or pintle. In the later stage the results are tabulated for two different speeds of flow namely Minimum and
Maximum. The graphs were plotted for Static Pressure, Velocity Magnitude, Turbulent Kinetic Energy, Cell Reynolds number
and Strain Rate and best model is assessed. The total study and simulation was performed using ANSYS Fluent 14.5.
Design of pipe-inspection robot for pipeline systems
Authors: Ashok Rajan
Published: July 2022

A Wheel based pipe inspection robot is designed for examining 300 mm to 400 mm diameter pipes which is mostly used in chemical and food industries. The fundamental point of this plan is to perform vertical slithering, autonomous multi elbow turning and support free and viable financial model. Planned robot consists of two significant modules, upper and lower module. Upper and lower course of action have three design wheel with straightforward scissor system for wheel extension. These two modules are associated by spring (compressive) to accomplish wheel extension and adaptable elbow turning. Full plan is done in solid works programming. Accordingly the robot configuration turns out great in vertical development and complex elbow turning.
De-centering the Human within a Virtual Environment: Creation of the Occular Oddity
Authors:   , Day Darroch
Published: July 2022

Humans have become the single most defining force on the planet placing themselves at the center of life on earth at the expense of other life forms. Landscape modification, of which landscape architecture is part of, is thus normatively composed to satisfy the needs, comforts and experiences of the human. How might landscape architecture challenge such a norm?

This exploratory digital research asks how landscape architecture can foreground and prioritize nonhuman needs in the creation and visualization of modified landscapes. It furnishes this ambition with the development of a Virtual Reality tool to be used by landscape architects in the design process. Intention here is to initiate ways that move towards overturning anthropocentric bias within landscape architecture. The landscape of Porirua is explored as a case study site to determine parameters from which to create testable conditions for the tool. A virtual environment is created to represent the selected non-human species scale and movement. The research develops, tests and critiques the tool development by creating a landscape design for the chosen non-human.

The result is a working visual assessment tool that decenters the human and creates an empathic link to the non-human, aiding the landscape architect within their design process. The research makes a contribution to an under-interrogated area of digital design in landscape architecture.
Sistema inalámbrico de alimentación inductivo de baja potencia para transferencia de energía a gran distancia
Authors: Narváez Acaro Alexis Adrián , Carretero Chamarro Claudio , Acero Acero Jesús
Published: July 2022

La transferencia inalámbrica de energía está considerada entre las tecnologías emergentes más atractivas del siglo XXI. En este documento se exponen los fundamentos aplicados a un sistema de alimentación inalámbrico de baja potencia para operar a mayores distancias de las habituales. Se presenta el sistema IPT a nivel hardware y software, y su implementación sobre un prototipo funcional.
Estimación del nivel de potasio en sangre mediante las pendientes del QRS del electrocardiograma en pacientes renales crónicos
Authors: Bukhari Syed Hassaan Ahmed , Sánchez Carlos , Potse Mark , Laguna Pablo , Pueyo Esther
Published: July 2022

Noninvasive estimation of serum potassium concentration can help prevent ventricular arrhythmias and sudden cardiac death in patients with chronic renal failure (CKD), but current outpatient estimation methods are limited. In this study, we estimated serum potassium concentration by evaluating the slopes of the “QRS complex” of the electrocardiogram in 29 patients with CRF during and after hemodialysis.
AtheromApp. Una herramienta para la segmentación de placas de ateroma
Authors: Latorre Molins Álvaro Tomás , Peña Baquedano Estefanía , Martínez Barca Miguel Ángel , Cilla Hernández Myriam , Ohayon Jacques
Published: July 2022

La detección precoz de placa de ateroma es de vital importancia clínica. Actualmente, el diagnóstico se realiza mediante imágenes médicas y segmentación manual. AtheromApp es una herramienta que utiliza una nueva metodología basada en los gradientes de deformación y permite segmentar placas obteniendo medidas relacionadas con su vulnerabilidad.
Deep Generative Models for Distributed Acoustic Sensors (DAS)
Authors: Almudévar Atienza Antonio , Ortega Alfonso
Published: July 2022

This paper presents two solutions based on Deep Learning techniques to detect mechanical events in signals coming from distributed acoustic sensors (DAS). Specifically, two systems for this task are described. The first one is a deterministic solution based on the concept of autoencoder (AE), while the second system is a stochastic solution based on the idea of Variational Autoencoder (VAE). The signals used for the tests have been provided by Aragón Photonics Labs (APL).
Aprendiendo física con grafos
Authors: Hernández Laín Quercus , Badías Alberto , Cueto Elías , Chinesta Francisco
Published: July 2022

El objetivo de este trabajo es utilizar inteligencia artificial para aprender las leyes físicas que gobiernan un sistema arbitrario y predecir así su evolución en el tiempo. Para ello se utilizan varios sesgos inductivos, que aseguran la correcta estructura matemática del problema y mejoran su capacidad de generalización.
Técnicas avanzadas para la concentración de antioxidantes naturales
Authors: Mur Sanchez Raquel , Pardo Juan Ignacio , Martínez José Francisco , Urieta José S. , Mainar Ana Mª
Published: July 2022

En este trabajo se aborda la concentración de antioxidantes de interés mediante procesos avanzados y sostenibles que emplean CO2 supercrítico, así como el estudio, en primera aproximación, de un modelo QSAR que permita en un futuro preseleccionar compuestos de interés para estos procesos.
Design of a Digitally Programmable Phase Shifter for Active Antenna Arrays
Authors: Esteban Eraso Uxua , Sánchez Azqueta Carlos , Celma Pueyo Santiago
Published: July 2022

This paper presents the design of a new phase shifter using CMOS technology of 65 nm, for its use in arrays of antennas opperating at the millimeter band (24 GHz). It is an active phase shifter digitally programmable using a 4-bit word.
Efectos Transitorios y en Estado Estacionario del Bloqueo del Canal SK y de la Estimulación Adrenérgica para Contrarrestar los Efectos Arritmogénicos Inducidos por Acetilcolina en la Aurícula Humana: un Estudio Computacional
Authors: Celotto Chiara , Sánchez Carlos , Mountris Konstantinos , Laguna Lasaosa Pablo , Pueyo Paules Esther
Published: July 2022

En este estudio se utiliza la simulación computacional para evaluar los efectos individuales y combinados del bloqueo de los canales iónicos SK y de la estimulación β-adrenérgica para contrarrestar los efectos proarrítmicos inducidos por la estimulación colinérgica en la electrofisiología auricular humana, tanto a nivel celular como tisular.
Caracterización experimental del comportamiento mecánico pasivo elástico y viscoelástico en ventrículo izquierdo de corazón de cerdo
Authors: Laita Dieste Nicolas , Martínez Miguel Ángel , Doblaré Manuel , Peña Estefanía
Published: July 2022

Con el objetivo de caracterizar mecánicamente el tejido cardiaco porcino, se han llevado a cabo diferentes ensayos mecánicos sobre siete animales. Se han realizado ensayos biaxiales y tangenciales, elásticos y viscoelásticos. El procedimiento utilizado permite caracterizar el comportamiento del tejido con cualquier modelo de material existente en literatura
Nuevos dispositivos de microfluídica para el estudio de la capacidad metastática y el efecto de la barotaxis
Authors: Juste-Lanas Yago , Guerrero Pedro Enrique , Camacho-Gómez Daniel , Hervás-Raluy Silvia , García-Aznar José Manuel , Gómez-Benito María José
Published: July 2022

Se han creado nuevos dispositivos de microfluidica que simulan estructuras anatómicas en forma de canal, para el estudio de la capacidad metastática de las células tumorales, así como el efecto de la batotaxis en ella. Nuestros resultados muestran que las células tumorales son capaces de sentir diferencias de presión.
Microfluídica inteligente: combinación del aprendizaje profundo y la microfluídica para predecir la evolución del glioblastoma.
Authors: Pérez-Aliacar Marina , Doweidar Mohamed H. , Doblaré Manuel , Ayensa-Jiménez Jacobo
Published: July 2022

Las numerosas posibilidades que ofrece la microfluídica a nivel de obtención y monitorización de grandes cantidades de datos abren la puerta a la aplicación de técnicas de aprendizaje profundo al análisis de la evolución cultivos celulares, un campo poco explorado hasta la fecha. En este trabajo, se desarrolla una red neuronal para identificar, a partir de imágenes de cultivos celulares de glioblastoma en dispositivos microfluidicos, los parámetros que gobiernan el comportamiento de este tumor cerebral.
De la realidad histológica a la metabólica: desentrañando la respuesta celular a partir de la evolución de cultivos celulares utilizando redes neuronales guiadas por la física.
Authors: Ayensa-Jiménez Jacobo , Doweidar Mohamed H. , Doblaré Manuel
Published: July 2022

La combinación de medidas en dispositivos microfluídicos con técnicas de inteligencia artificial permite estudiar fenómenos celulares complejos difíciles de encarar con los métodos tradicionales. En este trabajo se usan redes neuronales guiadas por la física para explicar los cambios metabólicos celulares y predecir el comportamiento de cultivos de glioblastoma ante estímulos variables, dando los primeros pasos hacia la medicina in silico personalizada.
CO2 methanation in a Ni-Fe based catalyst fixed bed reactor enhanced by selective water adsorption with LTA zeolites (Sorption Enhanced Sabatier Reaction – SESaR)
Authors: Mercader Plou Víctor Daniel , Rincón Mar , Sanz Andrés , Duran Paul , Francés Elena , Herguido Javier , Peña José Ángel
Published: July 2022

A Fixed-Bed reactor improved by selective water adsorption LTA zeolites is proposed as an alternative to the conventional methanation reactors. This reactor produces methane from renewable H2 (i.e. surplus electricity) and high CO2 concentration sources, as could be municipal wastes derived biogas (30%v CO2 + 70%v CH4). As catalyst, a supported (g-Al2O3) Ni-Fe (7.5:2.5 wt/wt) was chosen.
CO2 activation of char from argan nutshells pyrolysis a preliminary study
Authors: Afailal Zainab , Gil-lalaguna Noemí , Macías Robert J. , Gonzalo Alberto , Arauzo Jesus , Luis Sanchez Jose
Published: July 2022

CO2 physical activation was performed to produce activated carbons from pyrolysis char. The process was fed by char produced in the pyrolysis of argan nutshells. This unexplored feedstock is a residue of argan oil production. This preliminary study showed that the activated carbons obtained in this process are characterized by a large surface area and a great capacity to retain contaminants.
Implementación de multi-inversor resonante mediante dispositivos de banda ancha para calentamiento por inducción doméstico
Authors: Guillén Moya Pablo , Sarnago Andía Héctor , Lucía Gil Óscar , Burdío Pinilla José Miguel
Published: July 2022

En este artículo se propone la implementación de un inversor multi-salida mediante dispositivos de banda ancha (WBG) para calentamiento por indcción doméstico. Esta solución reduce las pérdidas de conmutación posiblitando la aplicación de estrategias de modulación más versátiles y precisas en el control de potencia.
Comparación de los efectos de la estimulación cardíaca convencional y la estimulación de rama izquierda sobre la despolarización y repolarización ventricular en el ECG
Authors: Sales Bellés Clara , Melero Jorge , Julián Inés , Ramos Javier , Mincholé Ana , Pueyo Esther
Published: July 2022

La estimulación de rama izquierda (ERI) ha surgido como alternativa a la convencional (EVD) en pacientes con marcapasos. Hemos comprobado que ERI lleva a mayor sincronía en la activación ventricular (complejo QRS más estrecho y menor área) y reducción en la dispersión de la repolarización (menor intervalo Tpe) que EVD.
Bayesian Classification of Affordances from RGB Images
Authors: Mur Lorenzo , Martínez-Cantín Rubén
Published: July 2022

We propose a Bayesian classification model using Deep Ensembles (DE) and MC-Dropout (MC-D) to predict affordances from RGB images. Our Bayesian model obtains a higher performance than previous works and captures the aleatoric and epistemic uncertainty, showing consistency with the type of objects and scenarios.
Thermal Intelligent Control DVFS for Cyber-physical Systems
Authors: Hernandez Almudi Pablo , Montijano Eduardo , Suárez Gracia Darío
Published: July 2022

This work explores the use of well-known control techniques to tackle the heat dissipation problem in embedded devices. These types of devices lack of good solutions for managing heat and the existing ones may lead to unpredictable performance variations. We will show a way of solving the problem with classic control theory and workload identification.
A Finite Element Based Optimization Algorithm to Include Diffusion into the Analysis of DCE-MRI
Authors: Sainz-DeMena Diego , Ye Wenfeng , Pérez María Ángeles , García Aznar José Manuel
Published: July 2022

DCE-MRI is a widly used technique to obtain a quantitative description of the tumour vasculature. Contrast agent diffusion has a great impact on the extraction of this descriptors. This work presents a new approach based on the FEM to account for this phenomenon. The proposed model outperforms the state-of-art models.
Terapias cardiacas avanzadas con microRNAs basadas en nanoestructuras de DNA
Authors: Hernández Bellido Natalia , Postigo Alejandro , Orrite Carolina , Garrido Huéscar Elisa , García Mendívil Laura , Pueyo Esther , Hernández Ainsa Silvia , Ordovás Vidal Laura
Published: July 2022

La desregulación de microRNAs (miRNAs) se asocia con múltiples procesos incluidos el envejecimiento cardiaco y las enfermedades cardiovasculares (ECV). Por ello, se posicionan como prometedoras dianas terapéuticas. Para superar limitaciones en su uso como tal, se propone la creación de nanoestructuras de DNA (DNS) biocompatibles para crear terapias efectivas y seguras.
La endotelina-1 aumenta la heterogeneidad de la repolarización ventricular en cerdos con infarto crónico de miocardio
Authors: Pérez Martínez Alba , Oliv´án-Viguera Aida , Pueyo Esther
Published: July 2022

Hemos comprobado mediante mapeo óptico que la respuesta electrofisiológica a la endotelina-1 (ET-1) del miocardio ventricular se ve alterada según la cercanía a las zonas afectadas por infarto de miocardio crónico. Estas diferencias electrofisiológicas no se observan en ventrículos sanos.
Rendimiento de carbones derivados de sarmiento como ánodos en baterías de iones de sodio: efecto de la temperatura de carbonización
Authors: Alvira Dobón Darío , Altorán Daniel , Antorán Daniel
Published: July 2022

Los carbones duros son uno de los principales candidatos para ser usados como material activo en los ánodos de las baterías de iones de sodio (SIBs). Para este estudio se han producido carbones duros a partir de sarmiento de vid (biomasa residual) mediante un proceso termoquímico de dos etapas: una pirólisis lenta a 500 °C seguida de otra carbonización en atmósfera inerte a mayor temperatura. El carbón obtenido a 1200 °C entregó la mayor capacidad reversible (270 mAh g–1 a 0.03 A g–1) gracias al equilibrio alcanzado entre la presencia de dominios pseudografíticos, defectos y grupos funcionales en superficie. Este trabajo presenta una ruta de preparación verde y sencilla para obtener carbones duros con una morfología y microestructura única y una prometedora actividad electroquímica.
Experimental and Simulated Study of Ammonia Combustion at High Pressures
Authors: García Ruiz Pedro , Uruen María , Alzueta Uxue , Abián María
Published: July 2022

El amoníaco se puede quemar directamente sin emisiones de CO2. El presente trabajo trata del estudio experimental y simulado de la conversión de NH3 a altas presiones a dos relaciones de exceso de oxígeno (lambda, l) 1 y 3, y diferentes presiones (de 10 a 40 bar).
Alberto Pascual - Recipientes con temperatura autolimitada para calentamiento por inducción domestico
Authors: Pascual Alberto
Published: July 2022

Recipientes con temperatura autolimitada para calentamiento por inducción domestico
Miguel Ángel Pastor -Detección automática de emociones a partir de la voz Combinación de bases de datos para aumentar el entrenamiento
Authors: Pastor Miguel Ángel
Published: July 2022

Detección automática de emociones a partir de la voz Combinación de bases de datos para aumentar el entrenamiento