bluuebunny/crossref_metadata_2025 huggingface dataset:
Ausencia, presencia, evocación. Un documento-monumento de un transitar jesuita: Diego de Rosales a Luis de Valdivia, Arauco, 1643
Authors: Gaune Rafael , Rolle Claudio
Published: May 2023

En este texto presentamos una edición crítica de un documento conservado en el Archivo Romano de la Compañía de Jesús, escrito por el jesuita Diego de Rosales en Arauco, Chile, el 20 de abril de 1643. El destinatario de la carta era el jesuita Luis de Valdivia que había fallecido, en Valladolid, el 5de noviembre de 1642. El remitente, al no conocer la noticia de la muertede Valdivia, convirtió implícitamente su texto en un retrato de una ausencia evocando su presencia a través de la referencia a los frutos del proyecto de guerra defensiva, ideado por Luis de Valdivia, entre 1612 y 1626, en el confín meridional del virreinato peruano.
In-silico Analysis for Prediction of Mutational Position and Designing of sgRNA for HDT701 Gene in Indian Rice cv. RPBio-226
Authors: Mathsyaraja Shravya , Saida Lavudi , Reddy Vutukuri Prathap
Published: May 2023

Background: In eukaryotes, Histone acetylation and deacetylation plays a prominent role in controlling gene expression and chromatin structure modifications. Both Histone acetyltransferases (HAT) and Histone deacetylases (HDACs) work in opposition to regulate chromatin acetylation. Reduced levels of histone H4 acetylation and increased susceptibility to the rice disease M. oryzae result from overexpression of HDT701 in rice. By changing the levels of histone H4 acetylation in defense-related and pattern recognition receptor (PRR) genes in rice, HDT701 reduces the activity of innate immunity which promotes resistance to M. oryzae. Crispr cas9 technology was created to change genes and modify characteristics, as well as to produce resistance to a variety of infections by focusing on possible biomolecules involved in plant defense mechanisms. Therefore the present study was aimed to design single guided RNA (sgRNA) and predict the gene mutational position in the HDT gene in RPBio-226 rice cv. Methods: To begin with, the DNA was isolated using CTAB method. Specific pair of primers was designed from the reference gene for amplification of HDT gene. In addition to, the PCR product was sequenced and the resulting sequence was applied to the creation of sgRNA. Furthermore, CHOPCHOP is a Bioinformatic search tool used to identify CRISPR–Cas single guide RNA (sgRNA) targets. Result: The isolated genomic DNA was quantified using nanodrop and found that the concentration of the DNA was 800-1000 ng/ul with the purity of 1.8. The full gene was amplified with OsHDT701 gene primers and sequenced. Based on the OsHDT701 gene sequence, oligo single guide RNA (sgRNA) was generated by using the http://chopchop.cbu.uib programme. The target site for designing sgRNA was found from 168 basepair to 190 basepair with the deletion of a nucleotide at 174th position.
Effect of Graded Levels of Dried Orange (Citrus sinensis) Byproducts on Production Efficiency, Blood Parameters and Antioxidant Status of Broiler Chickens
Authors: Readh CHAIB EDDOUR Ahmed , Miloud LITIM , Abdelkarim LARBAOUI , Kaddour BOUDEROUA , Chaima BELHOCINE
Published: May 2023

Background: Orange wastes are bioactive compounds produced during the industrial transformation.The experiment was conducted to evaluate the effects of feeding dried sweet orange byproducts (DOP) on broiler growth performance, serum metabolites and antioxidant status. Methods: A total of 200 of 20-day experimental broiler chicks were distributed into a completely randomized design which included 4 dietary treatments with 5 replicates of 10 birds fed each. The dietary treatments included a control diet with no corn substitution and three diets containing 5, 10 and 15% Dried Orange Pulp. Feed intake (FI), body weight gain (BWG), feed conversion ratio (FCR), carcass traits, serum components, and blood antioxidant status were measured. Result: FCR and BWG of chickens were improved when using graded levels of DOP compared to the control group (P less than 0.05). Serum total protein and glucose were significantly increased (P less than 0.0001) in DOP groups compared to the control. Serum Cholesterol and triglyceride decreased significantly (P less than 0.0001) in the DOP groups. Higher Aspartate amino transferase, Lactate Dehydrogenase and Creatine Phospho Kinase activities were observed in Control group compared to the other treatments.
The hybrid concept of turboshaft engine working according to Humphrey cycle dedicated to variety power demand – CFD analysis
Authors: Tarnawski Piotr
Published: May 2023

The paper presents a new concept of the turbine engine in the area of pressure gain combustion (PGE). The engine works according to Humphrey’s cycle. Minor modification in construction has allowed power generation of 500 kW, 700 kW, 1000 kW, and 1800 kW. The concept successfully resolved the challenges related to the temporary opening and closing of the combustion chamber. The presented valve timing system has ensured effective gas flow and what stands behind it, an effective process of conversion of a high-pressure gas impulse into mechanical energy. Rotating combustion chambers enabled the application of an effective sealing system. The concept characterizes simple construction and potentially low power-to-weight coefficient. The CFD numerical analysis of the presented engine concept showed very promising effective efficiency and low specific fuel consumption.
Chabloz vê Chico, Chico vê Chabloz: estudo de conceito de arte primitiva na obra pictórica de Chico da Silva
Authors:   Universidade Federal do Rio de Janeiro, Botelho Adriana Barroso
Published: May 2023

Em uma tradição da história da arte ocidental, no Ceará encontram-se influências ou vestígios de todos os movimentos artísticos que se desenvolveram no país. Esse percurso abrange da pintura rupestre, o barroco, neoclássico aos movimentos modernos.
Do quadro-objeto cubista ao não-objeto neoconcretista: uma análise a partir das leituras de Ferreira Gullar e Mário Pedrosa
Authors:   Universidade Federal do Rio de Janeiro, Almeida Diogo Vieira de
Published: May 2023

Desde o início do século XX, o campo das artes visuais se via em uma busca pela construção de um novo espaço de representação, que com o esgotamento da linguagem impressionista, tinha no cubismo um precursor, porém, seu sentido revolucionário e as experiências pictóricas cubistas só seriam retomadas com o movimento De Stijl, mas especificamente com a obra de Piet Mondrian.
Marta Traba e a construção de duas histórias da arte na América Latina
Authors:   Universidade Estadual de Campinas, Lodo Gabriela Cristina
Published: May 2023

Marta Traba (1930-1983) foi uma importante escritora e crítica de arte argentino-colombiana, formada em Filosofia e Letras pela Universidade Nacional de Buenos Aires, e História da Arte pela Sorbonne de Paris. Radicou-se em Bogotá na década de 1950, onde obteve a cátedra de História da Arte na Universidade Nacional da Colômbia, residindo no país até 1968, quando passou, então, por outras cidades, como: Montevidéu, Caracas, San Juan de Puerto Rico, Washington, Princeton, Barcelona e Paris.
The Role of Artificial Intelligence in Learning Empowerment for Primary School Students in Republic of Yemen: A survey of Experts' Opinions at Sana'a University
Authors: الحاوري أ. د. عبد الغني أحمد علي , الجمالي د. عبد الملك أحمد علي
Published: May 2023

Primary school students in the Republic of Yemen face many problems as a result of the educational system's inability to single out education and adopt the principle of individual differences and the theory of multiple intelligences. This was due to the scarcity of experts specialized in artificial intelligence in Ministry of Education who could have an active role in solving problems. This has led to students' negative attitudes towards learning; hence, this study aimed to identify the role that artificial intelligence could play in empowering students learning and increasing their desire for learning. The study adopted the descriptive approach and the questionnaire was distributed to a sample of 26 experts and specialists in artificial intelligence at Sana'a University in Computer College, the College of Engineering (Communication Department), and the College of Education (Educational Technology Department) to collect data about their opinions of the role that artificial intelligence could play in empowering primary school students learning in the Republic of Yemen. The findings revealed that the degree of artificial intelligence importance in empowering primary school students learning was high at the level of the four dimensions: (smart content, smart systems, student, teacher). The study recommends the establishment of a center for artificial intelligence in the Ministry of Education for qualifying schools, and technical and administrative cadres in artificial intelligence. The study also recommends the Ministry to grant an award for students who produce programs and applications of artificial intelligence, as well as an award for schools that use artificial intelligence in education.
White paper: ethics and trustworthiness of artificial intelligence in clinical surgery
Authors: Capelli Giulia , Verdi Daunia , Frigerio Isabella , Rashidian Niki , Ficorilli Antonella , Grasso Vincent , Majidi Darya , Gumbs Andrew A , Spolverato Gaya ,   Artificial Intelligence Surgery Editorial Board Study Group on Ethics
Published: May 2023

This white paper documents the consensus opinion of the Artificial Intelligence Surgery (AIS) task force on Artificial Intelligence (AI) Ethics and the AIS Editorial Board Study Group on Ethics on the ethical considerations and current trustworthiness of artificial intelligence and autonomous actions in surgery. The ethics were divided into 6 topics defined by the Task Force: Reliability of robotic and AI systems; Respect for privacy and sensitive data; Use of complete and representative (i.e., unbiased) data; Transparencies and uncertainties in AI; Fairness: are we exacerbating inequalities in access to healthcare?; Technology as an equalizer in surgical education. Task Force members were asked to research a topic, draft a section, and come up with several potential consensus statements. These were voted on by members of the Task Force and the Study Group, and all proposals that received > 75 % agreement were adopted and included in the White Paper.
The impact of climate change on grape yields: Evidence from Australia
Authors: Puga German , Anderson Kym , Doko Tchatoka Firmin
Published: May 2023

Precipitation patterns are projected to change in different directions across wine regions in Australia, but temperatures are projected to increase in all wine regions, making them less prone to frosts but more prone to heatwaves and more arid. This research aims to estimate how climate change could affect grape yields in Australia. This is, to our knowledge, the first study using a panel data framework to estimate the potential impact of climate change on grape yields. This framework involves a two-step approach in which the first step consists of estimating the impact of weather on grape yields using a fixed effects panel data model, and the second step involves estimating the potential impact of climate change projections using the estimates from the first step. We also estimate a novel hybrid model that interacts weather with climate, potentially accounting for long-run adaptation. The results suggest that climate change by 2050 may lead to higher yields in most regions but lower yields in some of the country’s largest regions. Put differently, an increase in yields may be expected in the coolest regions, while a decrease may be expected in the hottest regions. Consequently, the average yield in Australia may change very little.
Short and long-term acclimation to water status at leaf and plant level of fungus-tolerant genotypes
Authors: Wilhelm de Almeida Luciana , Pellegrino Anne , Fontez Bénédicte , Torregrosa Laurent , Ojeda Hernán
Published: May 2023

Today’s viticulture faces the double challenge of reducing chemical input while adapting plant material to future climate conditions. Adopting fungus disease-tolerant varieties appears to be a long-term solution as long as they are performant under abiotic constraints, such as drought. This study aimed to study the effects of water deficit (WD) and characterise the different strategies adopted to cope with drought in six new fungus disease-tolerant varieties selected by INRAE compared to Syrah. During five consecutive seasons (2018 to 2022), a gradient of WD was applied in field conditions and monitored through vine predawn water potential measurements. Grape development was non-destructively tracked by imaging to determine the arrest of berry phloem unloading. All variables were collected at the single plant level. The impacts of WD on leaf gas exchange and intrinsic water use efficiency (WUEi), vegetative development and yield components were assessed, as well as the genotypic sensitivity to WD at the leaf, vegetative and reproductive levels. All variables were negatively impacted by WD, except for intrinsic water use efficiency and total non-structural carbohydrate concentrations. Genotypes were differently impacted by WD at the physiological and vegetative levels, while no genotype-dependent response was observed for most reproductive variables. Generally, genotypes with the highest potential (highest intercept) in a certain variable were also the most sensitive to water deficit (higher slope). The most sensitive genotype regarding physiological and reproductive variables was G5, which showed higher reductions in berry weight, photosynthesis and WUEi, contrasting with Syrah, 3159B and Floreal. In this study, we observed a diversity of strategies to cope with WD in the long term, where some genotypes opted to reduce most variables (G5 and Artaban) or to maintain functioning at higher levels (Syrah and 3176N). Others displayed mixed responses: either reducing vegetative growth more than yield (3159B) or vice-versa (G14).
Thinking beyond Vaccination: Promising Add-On Strategies to Active Immunization and Vaccination in Pandemics - a Mini-Review
Authors: Tatzber Franz , Wonisch Willibald , Resch Ulrike , Strohmaier Wolfgang , Lindschinger Meinrad , Mörkl Sabrina , Cvirn Gerhard
Published: May 2023

There is little doubt that final victories over pandemics, such as COVID-19, are attributed to herd immunity, either through post-disease convalescence or active immunization of a high percentage of the world's population with vaccines, demonstrating protection from infection and transmission, being available in large quantities and at reasonable prices. However, it is assumable that humans with immune defects or immune suppression, e.g., as a consequence of allograft transplantation, cannot be immunized actively nor produce sufficient immune responses to prevent SARS-CoV-2 infections. These subjects desperately need other strategies, such as sophisticated protection measures and active immunization. Hypertonic salt solutions attack vulnerable core areas of viruses, i.e., salt denatures surface proteins and thus prohibits virus penetration of somatic cells. It has to be ensured that somatic proteins are not affected by denaturation regarding this unspecific virus protection. Impregnating filtering facepieces with hypertonic salt solutions is a straightforward way to inactivate viruses and other potential pathogens. As a result of the contact of salt crystals on the filtering facepiece, these pathogens become denatured and inactivated almost quantitatively. Such a strategy could be easily applied to fight against the COVID-19 pandemic and other ones that may occur in the future. Another possible tool to fight the COVID-19 pandemic is passive immunization with antibodies against SARS-CoV-2, preferably from human origin. Such antibodies can be harvested from patients´ human sera, which have successfully survived their SARS-CoV-2 infection. The disadvantage of a rapid decrease of the immunoglobulin titer after infection ends can be overcome by immortalizing antibody-producing B-cells via fusion with, e.g., mouse myeloma cells. The resulting monoclonal antibodies are then of human origin and available in, at least theoretically, unlimited amounts. Finally, dry blood spots are a valuable tool for surveilling the population´s immunity.
Co-Design/Co-Development and Evaluation of an Online Frailty Check Application for Older Adults: Participatory Action Research With Older Adults
Authors: Son Bo-Kyung , Miura Takahiro , Yabu Ken-ichiro , Sumikawa Yuka , Kim Dongyool , Lyu Weida , Yang Yingxue , Tanaka Moeko , Tanaka Tomoki , Yoshizawa Yasuyo , Iijima Katsuya
Published: May 2023

Frailty, an age-related decline in homeostatic reserves, markedly proceeded during the coronavirus disease 2019 pandemic. To continuously assess frailty status, a remote system is urgently required. We aimed to co-design/co-develop an online frailty check (FC) application alongside FC supporters who were facilitators in a pre-existing onsite FC program. The online FC included a screening measurement for sarcopenia and an 11-item questionnaire covering dietary, physical, and social behaviors. Using prototype applications, 55 opinions obtained from 32 FC supporters (median 74.0 years) were categorized and reflected refinement. Regarding the self-efficacy of FC supporters, a significant increase in social positioning was seen after the mock test (P=.031). For FC supporters and participants, the average system usability scale (SUS) score was 70.2±10.3 points, which was “marginally high” for acceptability and “good” for the adjective range. Multiple regression analysis showed that the SUS score was significantly correlated with online-onsite reliability but not online communication, even after adjusting by age, sex, education level, and ICT proficiency (b=0.400, 95% CI: 0.243-1.951, P=.013). Additionally, a significant association between onsite and online FC scores was observed (R=0.670, P=.001). Our online FC application was evaluated to be a valuable tool to practically assess frailty status remotely.
Co-Design/Co-Development and Evaluation of an Online Frailty Check Application for Older Adults: Participatory Action Research with Older Adults
Authors: Son Bo-Kyung , Miura Takahiro , Yabu Ken-ichiro , Sumikawa Yuka , Kim Dongyool , Lyu Weida , Yang Yingxue , Tanaka Moeko , Tanaka Tomoki , Yoshizawa Yasuyo , Iijima Katsuya
Published: May 2023

Frailty, an age-related decline in homeostatic reserves, markedly proceeded during the coronavirus disease 2019 pandemic. To continuously assess frailty status, a remote system is urgently required. We aimed to co-design/co-develop an online frailty check (FC) application alongside FC supporters who were facilitators in a pre-existing onsite FC program. The online FC included a screening measurement for sarcopenia and an 11-item questionnaire covering dietary, physical, and social behaviors. Using prototype applications, 55 opinions obtained from 32 FC supporters (median 74.0 years) were categorized and reflected refinement. Regarding the self-efficacy of FC supporters, a significant increase in social positioning was seen after the mock test (P=.031). For FC supporters and participants, the average system usability scale (SUS) score was 70.2±10.3 points, which was “marginally high” for acceptability and “good” for the adjective range. Multiple regression analysis showed that the SUS score was significantly correlated with online-onsite reliability but not online communication, even after adjusting by age, sex, education level, and ICT proficiency (b=0.400, 95% CI: 0.243-1.951, P=.013). Additionally, a significant association between onsite and online FC scores was observed (R=0.670, P=.001). Our online FC application was evaluated to be a valuable tool to practically assess frailty status remotely.
The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus
Authors: Moreli Jusciele B , Santos Mayk , Calderon Iracema , Hebeda Cristina , Farsky Sandra , Bevilacqua Estela , Oliani Sonia
Published: May 2023

The functions of annexin A1 (ANXA1) that is expressed on membranes and in cytoplasmic granules have been fully described. Nonetheless, the role of this protein in protecting against DNA damage in the nucleus is still emerging and requires further investigation. Here, we investigated the involvement of ANXA1 in DNA damage response in placental cells. Placenta was collected from ANXA1 knockout mice (AnxA1-/-) and pregnant women with gestational diabetes mellitus (GDM). The placental morphology and ANXA1 expression, which are related to the modulation of cellular response markers in the presence of DNA damage, were analyzed. Total area of AnxA1-/- placenta was smaller because of reduced labyrinth zone, enhanced DNA damage, and impaired base excision repair (BER) enzymes, which resulted in the induction of apoptosis in the labyrinthine and junctional layers. The placentas from pregnant women with GDM showed reduced expression of AnxA1 in the villous compartment, increased DNA damage, apoptosis, and reduction of enzymes involved in the BER pathway. Our translational data provide valuable insights into the possible involvement of ANXA1 in the response of placental cells to oxidative DNA damage and represent advancement in investigations on the mechanisms involved in placental biology.
Glucosinolate Diversity Analysis in Choy sum (Brassica rapa subsp chinensis var parachinensis) Germplasms for Functional Foods Breeding
Authors: Kim Seong-Hoon , Subramanian Parthiban , Hahn Bum-Soo
Published: May 2023

The aim of this study was to analyze glucosinolates (GSLs) in germplasms that are currently conserved at the RDA-Genebank. The analysis focused on the glucosinolate diversity among the analyzed germplasms, with the goal of identifying those that would be most useful for future breeding efforts to produce nutritionally rich Choy sum plants..Twenty-three accessions of Choy sum which possessed ample background passport information were selected. By analyzing the glucosinolate content for 17 different glucosinolates, we observed aliphatic GSLs to be the most common. We identified one accession, IT228140 to synthesize high quantities of glucobrassi-canapin and progoitrin which have been reported to contain several therapeutic applications. Overall, this study highlights the importance of conserving and analyzing plant genetic re-sources, such as those held in national genebanks, for the purpose of developing new varieties of crops that are both nutritious and beneficial for human health. The identification of excellent germplasms for breeding material and the confirmation of the anticancer effects of glucosin-olates are significant contributions to the field of agricultural research and have the potential to positively impact public health.
Approaches Used To Construct Antibiograms for Dogs in a Veter-Inary Teaching Hospital in the United States
Authors: Ekakoro John E. , Guptill Lynn , Hendrix Kenitra , Anderson Melinda , Ruple Audrey
Published: May 2023

Non-judicious antimicrobial use (AMU) is a major driver of antimicrobial resistance (AMR). In human hospitals, cumulative antibiograms are often used by clinicians to evaluate local susceptibility rates and to select the most appropriate empiric therapy with the aim of minimizing inappropriate AMU. However, use of cumulative antibiograms to guide empiric antimicrobial therapy in veterinary hospitals in the United States is limited, and there are no specific guidelines or standardized methods available for the construction of antibiograms in veterinary clinical settings. The objective of this methods article is to describe the approaches that were used to construct antibiograms from clinical samples collected from dogs seen at a veterinary teaching hospital. Laboratory data for 563 dogs for the period January 1, 2015 to December 31, 2015 was utilized. We used the Clinical and Laboratory Standards Institute (CLSI) guidelines for use in the construction of the antibiograms in human healthcare settings as the basis for the veterinary antibiograms. One general antibiogram, and antibiograms, stratified by hospital section, anatomic region of sample collection/ by sample type, were created and the challenges encountered in preparing these antibiograms are highlighted. The approaches described could be useful in guiding veterinary antibiogram development for empiric therapy.
The Phosphoproteome of the Degenerating rd1 Retina Changes After Protein Kinase G Inhibition
Authors: Zhou Jiaming , Welinder Charlotte , Ekström Per
Published: May 2023

Retinitis pigmentosa (RP) is a frequent cause of blindness among the working population in industrial countries, due to the inheritable death of photoreceptors. Though a gene therapy was recently approved for mutations in the RPE65 gene, there is generally no effective treatment presently. Previously, abnormally high-level cGMP and overactivation of its dependent protein kinase (PKG) have been suggested as causative for the fatal effects on photoreceptors, making it meaningful to explore the cGMP-PKG downstream signaling for more pathological insights and novel therapeutic target development purposes. Here we manipulated the cGMP-PKG system in degenerating retinas from the rd1 mouse model pharmacologically via adding a PKG inhibitory cGMP-analogue to organotypic retinal explant cultures. A combination of phosphorylated peptides enrichment and mass spectrometry was then applied to study the cGMP-PKG-dependent phosphoproteomics. We identified a host of novel potential cGMP-PKG downstream substrates and related kinases using this approach, and selected the RAF1 protein, which may act as both a substrate and a kinase, for further validation. We showed that the RAS/RAF1/MAPK/ERK pathway may be involved in retinal degeneration in a yet unclarified mechanism, thus deserving further investigation in the future.
Modeling of Sulfur and Iron Dynamics in Enclosed Bay Sediments and Evaluation of the Suppression Effect on Sulfides Release by Iron
Authors: Mochida Fumika , Miyatsuji Takashi , Nakamura Yoshiyuki , Inoue Tetsunori
Published: May 2023

In eutrophic waters, such as Mikawa Bay, Japan, anoxic bottom water develops in summer. This causes sulfide release into seawater by sulfate reduction in the sediment, leading to environmental problems. The addition of iron to sediments is a method used to improve the sediment environment, which was devised from a natural phenomenon. However, this method has not yet been quantitatively evaluated. In this study, we aim to quantitatively evaluate the suppressive effect of iron on sulfide release. First, we develop a sediment model that focuses on S and Fe. We then attempted to reproduce the observations and experiments on sulfide dynamics using the model. Consequently, the proposed model was able to reproduce field sulfur and Fe dynamics in sediments. Additionally, the model described the characteristics of sulfide release considering the effects of additive iron materials. Finally, we conducted predictive calculations and quantitatively evaluated the effects of adding iron materials to the sediments in terms of sulfur and iron cycles.
Predicting Soil Carbon Sequestration and Harvestable C biomass of Rice and Wheat by DNDC Model
Authors: Shaukat Muhammad , Hoshide Aaron Kinyu , Muhammad Sher , Arshad Irshad Ahmad , Mushtaq Muhammad , De Abreu Daniel C.
Published: May 2023

Biogeochemical models estimate soil organic carbon (SOC) sequestration, crop growth, and yield. The DeNitrification and DeComposition (DNDC) model was used to simulate soil SOC dynamics and harvested C-biomass in rice-wheat rotation under organic/inorganic fertilizations with conventional tillage (CT) and reduced tillage (RT). Before calibration, DNDC under-predicted harvestable grain C-biomass of rice by 29.22% to 42.14% and over-simulated grain C-biomass of wheat by 55.01% with equal amounts of NPK and animal manure applied under CT. However, after calibration by adjusting default values of soil/crop parameters, DNDC simulated harvestable grain C-biomass of both crops very close to observed values (only -2.81% to -6.17% less). DNDC also predicted effects of nutrient management practices on grain C-biomass of rice/wheat under CT/RT using d-index (0.76 to 0.96) and the calculated root mean squared error (RMSE of 165.36 to 494.18 kg C ha-1). DNDC simulated SOC trends for rice-wheat using measured values of several statistical indices. Regression analysis between modeled and observed SOC dynamics was significant with R2 ranging from 0.35 to 0.46 (p < 0.01), and intercept ranging from 0.30 to 1.34 (p < 0.65). DNDC demonstrated that combined inorganic and organic fertilization may result in higher C-biomass and more SOC sequestration in rice-wheat systems.
Analysis of ML Algorithm for Geriatric Fall Detection Due to the Effects of Various User Characteristics
Authors: Nandi Purab , Anupama K R , Agarwal Himanish , Patel Kishan , Bang Vedant , Bharat Manan , Guru Madhen Vyas
Published: May 2023

Falls are extremely damaging to the elderly. The number of elderly who have experienced falls has increased over the years, several of the elderly stay alone or in in badly maintained elderly homes. This makes a low-cost fall detection system a necessity. There has been huge improvements in terms of IoT systems, ML algorithms. Varied data sets have been collected across the world for fall detection. These data sets have a very little in common among them, in terms of user demographics, sensors used, the ADL and Fall activities Hence in this paper we present a data set that has wide user demographics, we used various sensors – such as accelerometer, gyroscope, magnetometer and hear rate. We used wrist worn sensors to collect data. In this paper we present a detailed analysis of the data set we collected using common ML algorithms such as – Naïve Bayes (NB), K Nearest Neighbor (KNN), Logistic Regression (LR), Random Forest (RF) and Support Vector Machines (SVM). We analyzed the performance of these algorithms for variations in accuracy with respect to age, gender, height, weight and health issues and we have identified outliers by analyzing each incorrect prediction. This paper provides the complete details of the data collection methodology, The methods used for analysis and presents the results of analysis in complete detail.
Phytochemical Characterization and Biological Activities of Stenomesson miniatum Bulb Extract, a Medicinal Plant of the Andes
Authors: Lianza Mariacaterina , Poli Ferruccio , Fimognari Carmela , Nuzillard Jean-Marc , Renault Jean-Hugues , Bonvicini Francesca , Greco Giulia , Turrini Eleonora
Published: May 2023

The fresh bulbs of Stenomesson miniatum, a plant belonging to Amaryllidaceae family with a poorly investigated phytochemical profile, were traditionally employed by Andean healers to treat tumors and abscesses. The aims of this study were to characterize the alkaloid extract from the bulbs of S. miniatum and test its cytotoxic and antibacterial potential. The alkaloid extract was characterized by dereplication using various techniques (CPC, NMR, UPLC-HRMS) and referring to in-home or online databases for spectroscopic data matching. Cytotoxic activities were evaluated on A431 human epidermoid carcinoma cells through a metabolic assay, and on Jurkat human acute T-leukemia cells through a cell-impermeant fluorescent nuclear probe. Antibacterial assays were carried out against Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes by using a standardized microdilution broth method 96-well plate. Eleven known Amaryllidaceae alkaloids were identified together with another compound determined as being an extraction artefact. The alkaloid extract showed good cytotoxic activity against both the tumor cell lines, reaching an IC50 of 3.3 µg/mL against A431 cells and of 10.9 µg/mL against Jurkat cells. The analysis of the fractions allowed the activity to be attributed to the presence of pretazettine and haemathamine. Conversely, no antibacterial activities were recorded for any of the samples.
Effective Quantization Evaluation Method of Functional Movement Screening with Improved Gaussian Mixture Model
Authors: Hong Ruiwei , Xing Qingjun , Shen Yuanyuan , Shen Yanfei
Published: May 2023

Background: Functional Movement Screening (FMS) allows for rapid assessment of an individual’s physical activity level and timely detection of sports injury risk. However, traditional functional movement screening often requires on-site assessment by experts, which is time-consuming and prone to subjective bias. Therefore, the study of automated functional movement screening has become increasingly important. Methods: In this study, we propose an automated assessment method for FMS based on the improved Gaussian Mixture Model (GMM). First, the oversampling of minority samples is conducted, the movement features are manually extracted from the FMS dataset collected with two Azure Kinect depth sensors, then we train the Gaussian mixture model with different scores (1 point, 2 points, 3 points) of feature data separately, finally, we conducted FMS assessment by the Maximum Likelihood estimation. Results: The improved GMM has a higher scoring accuracy (Improved GMM:0.8) compared to other models (Traditional GMM=0.38, Adaboost.M1=0.7, Naïve-Bayes=0.75), and the scoring results of improved GMM have a high level of agreement with the expert scoring (kappa=0.67). Conclusions: The results show that the proposed method based on the improved Gaussian mixture model can effectively perform the FMS assessment task and it is potentially feasible to use depth cameras for FMS assessment.
A Comprehensive Review of Organic Rankine Cycles
Authors: Jiménez José Camilo , Ruiz Alexis , Pacheco Alejandro , Rivera Wilfrido
Published: May 2023

Climate change is one of the main issues that humanity is currently facing due to carbon dioxide emissions caused by the use of fossil fuels. Organic Rankine cycles may play an important role in reducing these emissions since they can be operated by using industrial waste heat of renewable energies. The present study presents a comprehensive bibliographic review of organic Rankine cycles. The study not only actualizes previous reviews that mainly focused on basic cycles operating on subcritical or supercritical conditions but also includes the analysis of novel cycles such as two-stage and hybrid cycles and the used fluids. Recuperative and regenerative cycles are more efficient than reheated and basic single-stage cycles. The use of two-stage cycles makes it possible to achieve higher thermal efficiencies and net power outputs of up to 20% and 44%, respectively, compared with those obtained with single-stage cycles. Theoretical studies show that hybrid systems, including Brayton and organic Rankine cycles, are the most efficient; however, they require very high temperatures to operate. Most organic Rankine cycle plants produce net power outputs from 1 kW up to several tens of kW, mainly using microturbines and plate heat exchangers.
Egg Quality, Oxidative Status, Serum Metabolic Profile and Intestinal Morphology of Laying Hens as Influenced by a Dietary Mixed Powder of Plant Leaves
Authors: D'Alessandro Angela Gabriella , Desantis Salvatore , Fracchiolla Giuseppe , Porrelli Riccardo , Martemucci Giovanni
Published: May 2023

This study aimed to evaluate the effects of a mixture of olive, laurel and rosemary leaf powders, on performance and egg quality, the oxidative state and biochemical, immune, and intestinal morphophysiological parameters of laying hens. One hundred Lohaman Brown hens (28 weeks old) were equally assigned to two groups (n. 50) corresponding to a basal control diet (CON) or the diet supplemented with 6g/kg feed of leaf powder mixture (LPM) containing olive, laurel and rosemary leaves (1:1:1), for 8 weeks. Egg traits, oxidative status, biochemical indices, immune response, cecal short chain fatty acids (SCFAs) and intestinal morphological characteristics were evaluated at the end of the experiment. The results indicated that body weight and egg quality parameters were not influenced by LPM. However, LPM improved (P<0.01) the oxidative status and the immune system, total protein (P<0.05) and HDL cholesterol (P<0.01) and decreased total cholesterol (P<0.01) and LDL cholesterol (P<0.05), as compared to the CON. Aspartate amino transferase (AST), alkaline phosphatase (ALP) and alanine amino transpherase were significantly better in the LPM than in the CON group. A significant increase (P<0.05) of SCFA content established in the caecum and in villi height and crypt depth in both duodenum and ileum LPM treated hens was observed.
Genetic Basis of Inflammatory Demyelinating Diseases of the Central Nervous System: Multiple Sclerosis and Neuromyelitis Optica Spectrum
Authors: Ortiz Genaro Gabriel , Torres-Mendoza Blanca M.G. , Ramírez-Jirano Javier , Marquez-Pedroza Jazmin , Hernández-Cruz José J. , Mireles-Ramirez Mario A. , Torres-Sánchez Erandis D.
Published: May 2023

Demyelinating diseases alter myelin or the coating surrounding most nerve fibers in the central and peripheral nervous systems. The grouping of human central nervous system demyelinating disorders today includes Multiple Sclerosis (MS) and Neuromyelitis Optica Spectrum Disorders (NMOSD) as distinct disease categories. Each disease is caused by a complex combination of genetic and environmental variables, many involving an autoimmune response. Even though these conditions are fundamentally similar, research into genetic factors, their unique clinical manifestations, and lesion pathology has helped with differential diagnosis and disease pathogenesis knowledge. This review aims to synthesize the genetic approaches that explain the differential susceptibility between these diseases, explore the overlapping clinical features, and pathological findings, discuss existing and emerging hypotheses on the etiology of demyelination, and assess recent pathogenicity studies and their implications for human demyelination. This review presents critical information from previous studies on the disease, which asks several questions to understand the gaps in research in this field.
6 years of Pasteurella spp. in the Pitiusas
Authors: Jiménez-Guerra Gemma
Published: May 2023

Abstract: Pasteurella spp. is a gram-negative bacterium that is part of the oral and upper respiratory tract microbiota of many animals such as canids and felines. In humans it can produce pathology primarily associated with animal bites or scratches. In addition, members of this genus, and es-pecially Pasteurella multocida, may also be involved in systemic infections, mainly in immuno-compromised patients in close contact with pets. The aim of this study is to analyse the prevalence and clinical characteristics of infections caused by Pasteurella spp. as well as the sensitivity profile of these isolates obtained in the Microbiology laboratory of the Hospital Can Misses (Ibiza, Ibiza and Formentera Health Area, ASEF) in the period from January 2013 to December 2018. Retrospective descriptive study in which all Pasteurella spp. isolates were analysed in the Micro-biology Laboratory of Hospital Can Misses from 1 January 2013 to 31 December 2018. Bacterial identification was performed by Vitek 2 automated biochemical test panel (bioMérieux, Spain) and antimicrobial susceptibility also by Vitek2 automated microdilution panel, interpreted based on Clinical and Laboratory Standards Institute (CLSI) standards. Medical records were systematically reviewed by collecting demographic data of infected patients, comorbidities, epidemiological data and clinical features of the infection. A total of 22 isolates of Pasterurella spp. were obtained from 22 different patients, 62.8% female, from three different species: 18 P. multocida, 2 P. canis and 2 P. pneumotropica. Most isolates came from soft tissue infection samples: 7 wound exudates and 5 abscess material. The antibiotics tested with the highest sensitivity profile were gentamicin and cefepime (100% sensitivity
Bibliometric Study of the Systematic Reviews and Meta-Analyses in Dentistry
Authors: Tarazona Álvarez Beatriz , López Roldán Andrés , Vidal-Infer Antonio , Alonso-Arroyo Adolfo
Published: May 2023

Objective: To carry out a bibliometric analysis study of systematic reviews and meta-analyses in dentistry, divided into different thematic areas.
Material and method: A search was conducted in the Science Citation Index-Expanded on the core collection of Web of Science, they were selected from the area of Dentistry and Oral Surgery and Medicine categories, the data was downloaded on April 20, 2022 and The 100 most cited articles from each of the thematic areas were selected.
Results: An increase in this type of articles was observed in the last decade in the areas of pediatric and medical dentistry and oral pathology. The thematic area that received the most citations was periodontics. The two authors with the most citations are Zwahlen, Marcel and Pjetursson, Bjarni Eluar.
The countries that receive the most citations are European, along with the USA and China. The topics that are most published in this type of article deal with Cancer with 50 publications, caries treatment with 25 and fluoridation with 1. The entities that finance this type of articles the most are private companies (26.76%).
Conclusions: Together with an exponential increase in the number of publications in dentistry, there has been an increase in the number of publications in systematic reviews. The areas publishing the most articles and having the most citations are Periodontics and Implantology, despite the fact that the most studied topic is cancer.
Rich and Easy to Deceive? The Influence of Money Priming on the Ability to Detect Deception
Authors: Ende Luise , Reinhard Marc-André
Published: May 2023

Based on recent popular money priming research results, which conclude that money 4 makes self-sufficient (e.g. less interest in other people), we assumed that people are less interested 5 in finding out whether others are lying or telling the truth. In a laboratory experiment, 163 students 6 (85 women, 78 men, MAge = 23.08, ranging from 18 to 36 years) were primed by actively handling 7 money (versus paper sheets). Afterwards, they classified 24 video statements as true or deceptive 8 (senders describing their most/least favorite movie), rated their classification confidence for each 9 decision and then answered control questions. Results revealed no influence of priming condition 10 on judgmental bias, classification accuracy, and classification confidence. Also the level of self-re-11 ported motivation to find out who lied or told the truth did not differ between conditions. Higher 12 motivation was correlated to higher classification confidence. Additionally, and in line with Rein-13 hard (2010) and Reinhard et al. (2011), higher classification accuracy correlated to a higher use of 14 verbal content cues for classification decisions. So, while we were able to replicate these findings, 15 our results contradict the assumption of a money prime influence on lie detection ability. Conclud-16 ing, our results make self-sufficiency in this context questionable and offer next steps for research.
Chinese Document-Level Emergency Event Extraction Dataset and Corresponding Methods
Authors: Chu Kongbin , Yang Wenzhong , Wei Fuyuan , Shi Jiangtao
Published: May 2023

Structured extraction of emergency event information can effectively enhance the ability to re-spond to emergency events. This article focuses on the extraction of Chinese document-level emergency events, which mainly faces two key issues in this field: first, related datasets; Secondly, existing DEE (document-level event extraction) studies mostly use sequence annotation to extract candidate entities in the subtask of candidate entity extraction without considering the problem of role overlapping between candidate entities. On the one hand, this article constructs a Chinese document-level emergency extraction dataset, CDEEE, which first annotates the issues of argu-ment scattering, multiple events, and role overlapping. On the other hand, this article proposes a model RODEE for the problem of role overlapping in DEE tasks. This model first uses two in-dependent modules to represent the head and tail positions of candidate entities, then uses a multiplication attention mechanism to interact with the two to obtain a scoring matrix. Finally, role-overlapping candidate entities are predicted to assist in completing DEE tasks. Experiments were conducted on our manually annotated dataset, CDEEE, and the results showed that RODEE can effectively solve the problem of role overlapping in candidate entities and improve the performance of the DEE model.
Recent Insight About HE4 Role in Ovarian Cancer Oncogenesis
Authors: Anastasi Emanuela , Farina Antonella , Granato Teresa , Colaiacovo Flavia , Pucci Beatrice , Tartaglione Sara , Angeloni Antonio
Published: May 2023

Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.
The Importance of Entomo-Virological Investigation of Yellow Fever Virus to Strength Surveillance in Brazil
Authors: Cruz Ana Cecília Ribeiro , Hernández Leonardo Henrique Almeida , Aragão Carine Fortes , Da Paz Thito Yan Bezerra , Silva Sandro Patroca da , Silva Fábio Silva da , Aquino Ana Alice , Cereja Glennda Juscely Galvão Pereira , Nascimento Bruna Lais Sena do , Rosa Junior José Wilson Rosa Junior , Elias Carmeci Natalina , Nogueira Cristiano Gomes , Ramos Daniel Garkauskas , Fonseca Vagner , Giovanetti Marta , Alcantara Luiz Carlos Junior , Nunes Bruno Tardelli Diniz , Vasconcelos Pedro F. da Costa , Martins Livia Carício , Nunes-Neto Joaquim Pinto
Published: May 2023

After eight decades, the largest outbreak of sylvatic yellow fever virus (YFV) was recorded in Brazil between 2016-2018. Besides human and NHP surveillance, the entomo-virological approach is considered as a complementary tool. For this study, a total of 2904 mosquitoes of Aedes, Haemagogus and Sabethes genera from six Brazilian states (Bahia, Goiás, Mato Grosso, Minas Gerais, Pará, and Tocantins), were collected and grouped in 246 pools, which were tested for YFV using RT-qPCR. We detected 20 positive pools from Minas Gerais, 5 from Goiás, and 1 from Bahia, including 12 of Hg. janthinomys and 5 of Ae. albopictus. This is the first description of natural YFV infection in this species and warns of the likelihood of urban YFV re-emergence with the Ae. albopictus as a potential bridge vector. Three YFV sequences from Hg. janthinomys from Goiás and one from Minas Gerais, as well as one from Ae. albopictus from Minas Gerais clustered within the 2016-2018 outbreak clade, indicating YFV spread from Midwest and its infection in a main and in a likely-novel bridging vector species. Entomo-virological surveillance is critical in the YFV monitoring in Brazil, which could highlight the need to strengthen YFV surveillance, vaccination coverage, and vector control measures.