bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Composting Growing Media Time and Rice Husk Addition in Auricularia auricula Cultivation
Authors: Subali Dionysius , Givianty Vasya Theodora , Hartanti Anastasia Tatik , Karmawan Listya Utami
Published: January 2024

AbstractAuricularia auricula is a wood mushroom that is commonly consumed and is in demand by the people as a food ingredient because it contains many nutrients and health benefits. Cultivation of A. auricula was carried out using growing media and controlled environmental conditions. This study objective to determine the optimal combination of composting time and the rice husks addition in the A. auricula production. The treatment in this study was the composting time of the growing media for 0, 2, 4, 6, and 8 days, as well as the addition of rice husks as much as 0, 25, and 50%. This research consisted of the preparation of growing media, spawning and incubation of A. auricula, and harvesting of fruit bodies. The success of mushroom cultivation is seen from the value of biological efficiency in each treatment. The combination treatment of 8 days composting time with the addition of 50% rice husk resulted in A. auricula production as much as 52.37%, while the combination of 4 days composting time treatment and the addition of 25% rice husks resulted in the best production of A. auricula, as it produced the mushroom weight of 340 ± 16.95 g with biological efficiency value as much as 68% for five harvest durations within four months after first watering. The treatment of composting media tie and the addition of rice husks to A. auricularia’s were successfully carried out.AbstrakAuricularia auricula merupakan jamur kayu yang umum dikonsumsi dan diminati oleh masyarakat sebagai bahan pangan karena mengandung nutrisi dan banyak manfaat. Budi daya A. auricula dilakukan dengan menggunakan media tanam dalam kondisi lingkungan yang terkontrol. Penelitian ini bertujuan menentukan kombinasi perlakuan waktu pengomposan dan penambahan sekam padi yang optimum terhadap produksi A. auricula. Perlakuan pada penelitian ini adalah waktu pengomposan media tanam selama 0, 2, 4, 6, dan 8 hari, serta penambahan sekam padi sebanyak 0, 25, dan 50%. Penelitian ini tersusun atas pembuatan media tanam, pembibitan dan inkubasi A. auricula, dan pemanenan tubuh buah. Keberhasilan budi daya jamur dilihat dari nilai efisiensi biologi pada setiap perlakuan. Kombinasi perlakuan pengomposan 8 hari dengan penambahan sekam padi 50% menghasilkan produksi A. auricula sebesar 52,37%, sedangkan kombinasi perlakuan waktu pengomposan 4 hari dan penambahan sekam padi 25% menghasilkan produksi A. auricula terbaik karena menghasilkan berat jamur sebanyak 340 ± 16,95 g dengan nilai efisiensi biologi sebesar 68% selama lima durasi panen dengan waktu empat bulan setelah dilakukan penyiraman pertama. Secara keseluruhan, perlakuan waktu pengomposan media dan penambahan sekam padi pada media pertumbuhan A. auricula berhasil dilakukan.
Overuse Injuries, Overtraining, and Burnout in Young Athletes
Authors: Brenner Joel S. , Watson Andrew ,   COUNCIL ON SPORTS MEDICINE AND FITNESS, Brooks Margaret Alison , Carl Rebecca L. , Briskin Susannah M. , Canty Greg , Cuff Steven , Edwards Nicholas M. , Kinsella Sarah , Lang Pamela J. , Master Christina Lin , Miller Shane Michael , Peterson Andrew , Silva Francisco Jose , Stricker Paul , Walter Kevin D. , Faigenbaum Avery , Diamond Alex Benjamin , Elder Patrice C. , Emanuel Anjie
Published: January 2024

Sports participation can have tremendous physical and mental health benefits for children. Properly implemented progressive training programs can yield a broad range of beneficial physiologic adaptations, but imbalances of training load and recovery can have important negative consequences. Overuse injuries, for example, can result from repetitive stress without sufficient recovery that leads to accumulated musculoskeletal damage. In addition, extended periods of increased training loads that exceed the intervening recovery can have systemic consequences such as overtraining syndrome, which results in decreased performance, increased injury and illness risk, and derangement of endocrine, neurologic, cardiovascular, and psychological systems. Burnout represents one of the primary reasons for attrition in youth sports. Broadly defined as physical or mental exhaustion and a reduced sense of accomplishment that leads to devaluation of sport, burnout represents a direct threat to the goal of lifelong physical activity and the wide-ranging health benefits that it provides. This clinical report is intended to provide pediatricians with information regarding the risk factors, diagnosis, management, and prevention of these conditions to assist in the identification of at-risk children, the treatment of young athletes, and the guidance of families in the promotion of safe and healthy sport participation.
Protestando contra todo lo que la belleza no es. O ¿por qué es tan bello el mundo?
Authors: Gualdrón Ramírez Miguel
Published: January 2024

En este texto reconstruyo una concepción decolonial de la belleza, a partir del pensamiento de Robin Wall Kimmerer y Édouard Glissant, de acuerdo con la cual la belleza constituye una condición del mundo que, no obstante, debemos cuidar. En estos dos pensamientos, provenientes de tradiciones diferentes, la belleza es tanto lo que se ve amenazado por el proyecto colonial occidental, como lo que permite su resistencia decolonial. Reconstruir la belleza del mundo es necesario y, sin embargo, imposible: su búsqueda implica no solo atender al llamado de las diferencias, sino también a las instancias en las que se niegan a ser escuchadas.
Armonizar a Pirrón y Enesidemo Sobre una línea problemática de Aristocles y su contexto
Authors: Correa Motta Alfonso
Published: January 2024

En este artículo argumento en contra de una intervención textual, sugerida por Moraux y adoptada por Chiesara, a una línea del tratado de Aristocles sobre la filosofía pirrónica. Esta lectura conservadora me permite resaltar la importancia del contexto en el que se inserta la línea en disputa. Pienso que el pasaje es crucial para la crítica de Aristocles a los escépticos, pues implica un intento consciente, aunque implícito, por unificar dos corrientes distintas del pirronismo: la original, representada por la apropiación de Timón de las palabras de Pirrón, y la más cercana aAristocles, representada por Enesidemo.
Los argumentos de Wittgenstein contra el escepticismo filosófico Una lectura terapéutica combativa de inspiración pragmatista
Authors: Lastres Dammert Pamela
Published: January 2024

El artículo analiza las principales intuiciones de inspiración pragmatista empleadas por el segundo Wittgenstein contra el escepticismo filosófico. Comparte con Peirce una orientación epistemológica antiescéptica que comprende: i) el rechazo de la duda filosófica, ii) el compromiso con certezas y el falibilismo, y iii) la defensa de una visión no intelectualista de la creencia. Con James comparte un enfoque metodológico en el que destaca la forma de deconstruir y replantear los problemas filosóficos. Conocer aquella orientación epistemológica y este enfoque metodológico torna más nítida la aproximación terapéutica con la que combate Wittgenstein el escepticismo filosófico.
El filósofo que sabe decir adiós A propósito del giro ético en el escepticismo de Marquard y Weischedel
Authors: Palacio Muñoz Manuel Darío
Published: January 2024

El artículo presenta la vertiente práctica del escepticismo alemán de Odo Marquard y Wilhem Weischedel en tres momentos: inicio con la propuesta de Marquard, quien lo define como la sensibilidad para lo usual, en vez de un sistema de criterios veritativos; prosigo con la Ética Escéptica de Weischedel, mostrando que la cuestionabilidad radical de la realidad abre un espacio para que el escéptico pueda formular siempre una pregunta; y termino mostrando que, a partir de Weischedel y Marquard, la despedida se erige como la actitud fundamental del escepticismo práctico.
Escepticismo y feminismo Una alianza posible
Authors: González Quintero Catalina , Wolf Allison B.
Published: January 2024

Este artículo problematiza la forma en la que el feminismo ha interpretado al escepticismo como una amenaza para su proyecto epistemológico, ético y político, y plantea que, a pesar de dicha interpretación, el escepticismo es inherente a la filosofía feminista y un aliado útil para su proyecto. El problema ha estado en cómo el feminismo ha reducido su comprensión del escepticismo a una versión cartesiana extrema y ha pasado por alto otras corrientes de la tradición —como la de David Hume— que podrían ser fructíferas para promover una actitud crítica y emancipatoria. Muestra así como una alianza entre una comprensión moderada del escepticismo y el feminismo puede brindar las herramientas necesarias para cuestionar formas de dominación patriarcal y poner en marcha investigaciones que combatan la opresión de género.
Filosofía y existencia en las lecciones de Heidegger de 1924/25 sobre el Sofista dePlatón
Authors: Solans Blasco Miquel
Published: January 2024

El presente artículo se centra en el estudio de la interpretación del Sofista, de Platón, desarrollada por Heidegger en las lecciones del semestre de invierno de 1924/25 en la Universidad de Marburgo. En particular, en él se ofrece una reconstrucción de la lectura heideggeriana a este diálogo desde la perspectiva que abre la consideración de la filosofía como un modo de existencia. Con este objetivo, se analizan dos claves centrales del comentario de Heidegger: la contraposición de la filosofía con la sofística y la contraposición de la filosofía con la adhesión dogmática a unos principios de escuela. En la parte final del artículo se desarrollan también algunas implicaciones del análisis anterior para la interpretación de la función del interlocutor principal de este diálogo, el Extranjero de Elea, así como de la naturaleza de la investigación filosófica tal y como es presentada por Platón en el Sofista.
Application of Binary Response Regression Models to Detect Factors Influencing the Occurrence of Infection in Dental Surgeries
Authors: Silva Pollyane , Vigas Valdemiro , Silva Cristiane , Barreto Ananda , Oliveira Jr Paulo , Savian Taciana , Isis Santos Isis Santos
Published: January 2024

Postoperative infection is common in dental surgery, for example, in the removal of the third molar. To control these and other postoperative complications, various studies have reported the use of some drug protocols, namely the prophylact and the preemptive ones, using drugs such as dexamethasone and betamethasone. In this work, we used the generalized linear model via logistic regression to verify whether, in addition to the medicaments mentioned, some covariates that are frequently used in dental surgeries influence the occurrence, or not, of postoperative infection in surgeries for removal of the third molar. One of the main reasons that led us to employ such a model is because the response variable (having or not having infection) presents values of the binary type, in addition to being one of the most applied models in the area of health, among them, the dentistry area. The application of descriptive methods and analysis of association via statistical tests were also used to choose other factors that influence the response variable infection in addition to medications. The AIC (Akaike Information Criterion) selection criterion, analysis of the difeerence in the deviations, and the analysis of residual using the half-normal plot for selection and the assumption of the proposed model were employed. The data set under analysis consists of 113 patients submitted to dental surgery in a specialized clinic in the city of Piracicaba, SP-Brazil between 2003 and 2018. Through the proposed model, some important information the covariates in relation to the patients submitted to dental surgery. One of the key information is that characteristics as Age and Dental extractions are associated with the inflammatory processes after surgery. This relationship indicates that the older the patient, the chance of having an infection after surgery increases. The analysis is similar to the Number of extractions.
Robust Circular Logistic Regression Model and Its Application to Life and Social Sciences
Authors: Castilla Elena
Published: January 2024

This paper presents robust estimators for binary and multinomial circular logistic regression, where a circular predictor is related to the response. An extensive Monte Carlo Simulation Study clearly shows the robustness of proposed methods. Finally, three numerical examples of Botany, Crime and Meteorology illustrate the application of these methods to Life and Social Sciences. Although in the Botany data the proposed method showed little improvement, in the Crime and Meteorological data an increment up to 5\% and 4\% of accuracy, respectively, is achieved.
Tratamento da correção monetária dos juros da dívida interna
Authors: ALVES SÍLVIO RODRIGUES
Published: January 2024

RESUMO O objetivo deste trabalho é defender o ponto de vista de que, assim como os pagamentos de amortizações não representam parte da dívida do setor público, o correção monetária da dívida e outros encargos similares não devem ser considerados como parte desse déficit. Essa afirmação deve ser ainda mais enfatizada no caso de países com altas taxas de inflação, onde os gastos com indexação monetária e outros encargos similares passaram a ter, progressivamente, maior participação no Produto Interno Bruto. Para um melhor entendimento da real situação financeira do Governo, foi feito um ajuste na série das contas nacionais. Nesse sentido, e para dar andamento à política fiscal, foi excluído da despesa com encargos da dívida interna o valor correspondente à correção monetária. Isso significa que a indexação monetária em um contexto de altas taxas de inflação é melhor classificada como principal do que como encargo da dívida. É importante notar que este artigo se baseia em outro anterior, também de Sílvio Rodrigues Alves, intitulado “O Desafio do Déficit Público”, publicado na Revista de Economia Política n.” 30 (abril-junho/1988). em junho de 1988, o mesmo ponto de vista foi defendido pelo Sr. Blezer, Sr. Tanzi e Sr. 1988).
Integration of physicochemical and instrumental quality data to estimate the texture of polished rice
Authors: Bento Juliana Aparecida Correia , Silva Marília Araújo , Rosário Neto Antônio , Souza Neto Menandes Alves de , Narciso Marcelo Gonçalves , Colombari Filho José Manoel , Bassinello Priscila Zaczuk
Published: January 2024

ABSTRACT: This research evaluated different rice genotypes regarding physicochemical and instrumental parameters of grain quality and associated the data with sensory analysis to support the creation of rules for classification of the culinary quality of rice (texture), based on isolated or combined parameters. The combination of amylose content and gelatinization temperature was able to predict the rice quality. According to the sensorial panel, the instrumental stickiness was able to segregate rice with very low amylose content or waxy to the other ones. Regarding pasting properties, rice that presented high final viscosity (310-480 RVU), setback (165-245 RVU), and pasting temperature (78 - 88 °C), and low values for breakdown (15-120 RVU), associated with a high stickiness (>-5N) was desirable by the Brazilian consumers. The classification rules created through the relationship between the physicochemical parameters and the texture profile evaluated by the sensory panel will help to verify the culinary profile of the rice samples (through free software), which makes it easier to predict the probability of rice meeting the desired quality standards.
Floristic data to support conservation in the Amazonian canga
Authors: Silva Livia Gadelha , Lovo Juliana , Fonseca-da-Silva Taiana Laura da , Riul Pablo , Silva-Luz Cíntia Luíza da , Zappi Daniela C.
Published: January 2024

Abstract Canga is an environment of great natural and economic value because it harbours a considerable number of endemic species on a substrate that is rich in iron ore. In the Amazon, this open vegetation type grows on top of isolated outcrops in a dense forest matrix found in the Carajás region, in southeastern Pará. Of these outcrops, the Parque Nacional dos Campos Ferruginosos (PNCF) is the only area of Amazonian canga with a strict protection status. Therefore, industrial activity in the region needs to implement mitigation actions to ensure species and habitat conservation. The objective of this study is to complement and review the floristic list of this recently created protected area, enabling us to compare the floristic similarity between it and other 14 Amazonian canga outcrops found outside the conservation units of full protection in the region. This data provides a basis to understand the floristic and phylogenetic complementarity of those patches to support conservation action. For this, six field trips were carried out in the Serra da Bocaina and two in the Serra do Tarzan, respectively, in order to increase the sampling efforts in PNCF and to obtain a more comprehensive plant list. Floristic composition was investigated using multivariate analyses (non-metric multidimensional scaling and unweighted pair group method with arithmetic mean) and phylogenetic structure across studied areas. We added 159 species to the floristic list of the PNCF and the results of the analyses showed that all 16 areas (n.b. PNCF comprises two of these sites) have an overall floristic similarity of 42%, with the least similar areas at 35% and the most similar at 50%. The different micro-habitats found in each study site highlight the high beta diversity of the Amazonian canga sites, making each area unique. Therefore, even if the Parque Nacional dos Campos Ferruginosos does not harbour all the species found in the other Amazonian canga sites, it is strategic for the conservation of the vegetation on ferruginous outcrops in the Amazon, protecting its biodiversity, different habitats, and associated ecosystem services.
Revisitando dois problemas clássicos do Irodov sobre curvas de perseguição
Authors: Cunha Felipe Costa Melo , Sampaio Rudini
Published: January 2024

O clássico livro de I. E. Irodov intitulado “Problems in General Physics” de 1981, bem conhecido como Irodov entre os estudantes, contém dois problemas de perseguição entre partículas com velocidades constantes em 2 dimensões que inspiraram variantes em recentes Olimpíadas de Física e vestibulares do IME e do ITA. Neste artigo, apresentamos em um único texto as versões mais estudadas desses problemas, incluindo soluções e simulações computacionais usando recursos avançados do Desmos, um sistema gráfico online e gratuito. Além disso, mostramos os cálculos das curvas exatas das trajetórias da perseguição nas variantes e mostramos que coincidem com as simulações computacionais. Finalmente, consideramos novas variantes naturais, como perseguição envolvendo mais pontos em diferentes trajetórias, e obtemos resultados computacionais para elas.
EDUCAÇÃO DEMOCRÁTICA E ALTERIDADE: RESPOSTAS POLÍTICA E ÉTICA À METAFÍSICA DA ECONOMIA
Authors: Farinon Mauricio João
Published: January 2024

RESUMO Resultado de pesquisa bibliográfica na matriz teórica de Amartya Sen, este ensaio teve como objetivo localizar a democracia e a alteridade como respostas políticas e éticas à metafísica da economia. Em perspectiva filosófica, teorizou-se sobre a democracia como espaço privilegiado de promoção das liberdades instrumentais e da liberdade substantiva e também acerca da perspectiva de alteridade que se abre na obra seniana conforme a fundamentação plural e a não maximização do autointeresse. A educação é defendida muito mais do que uma oportunidade social, sendo ato de formar o comportamento de infinito no horizonte histórico finito. Igualmente, defendeu-se a guinada que a educação precisa fazer em direção à esfera existencial, enquanto formação para a corresponsabilidade por pertencermos a um mundo comum.
Identification of Key Ubiquitination-Related Genes and Their Association with Immune Infiltration in Osteoarthritis Based on the mRNA-miRNA Network
Authors: Yuan Dalu , Shen Hailiang , Bai Lina , Li Menglin , Ye Qiujie
Published: January 2024

Osteoarthritis (OA) is a prevalent degenerative joint disease that is closely associated with functions of ubiquitination and immune cells, yet the mechanism remains ambiguous. This study aimed to find core ubiquitination-related genes and their correlative immune infiltration in OA using weighted gene co-expression network analysis (WGCNA). The ubiquitination-related genes, datasets GSE55235 and GSE143514 were obtained from open databases. WGCNA got used to investigate key co-expressed genes. Then, we screened differentially expressed miRNAs by "limma" package in R, and constructed mRNA-miRNA network. We conducted function enrichment analysis on the identified genes. CIBERSORT was then utilized to analyze the relevance between immune infiltration and genes. Lastly, RT-qPCR was further used to verify the prediction of bioinformatics. A sum of 144 ubiquitination-related genes in OA were acquired. Enrichment analysis indicated that obtained genes obviously involved in mTOR pathway to regulate the OA development. GRB2 and SEH1L and L-arginine synergistically regulate the mTOR signaling pathway in OA. Moreover, GRB2 and SEH1L were remarkably bound up with immune cell infiltration. Additionally, GRB2 expression was upregulated and SEH1L level was downregulated in the OA development by RT-qPCR experiment. The present study identified GRB2 and SEH1L as key ubiquitination-related genes which were involved in immune infiltration in OA patients, thereby providing new drug targets for OA.
Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Gene Analysis
Authors: Shen Jian , Li Minzhe
Published: January 2024

Gastric cancer (GC) is highly heterogeneous and influenced by aging-related factors. This study aimed to improve individualized prognostic assessment of GC by identifying aging-related genes and subtypes. Immune scores of GC samples from GEO and TCGA databases were calculated using ESTIMATE and scored as high immune (IS_high) and low immune (IS_low). ssGSEA was used to analyze immune cell infiltration. Univariate Cox regression was employed to identify prognosis-related genes. LASSO regression analysis was used to construct a prognostic model. GSVA enrichment analysis was applied to determine pathways. CCK-8, wound healing, and Transwell assays tested the proliferation, migration, and invasion of the GC cell line (AGS). Cell cycle and aging were examined using flow cytometry, β-galactosidase staining, and Western blotting. Two aging-related GC subtypes were identified. Subtype 2 was characterized as lower survival probability and higher risk, along with a more immune-responsive tumor microenvironment. Three genes (IGFBP5, BCL11B, and AKR1B1) screened from aging-related genes were used to establish a prognosis model. The AUC values of the model were greater than 0.669, exhibiting strong prognostic value. In vitro, IGFBP5 overexpression in AGS cells was found to decrease viability, migration, and invasion, alter the cell cycle, and increase aging biomarkers (SA-β-galactosidase, p53, and p21). This analysis uncovered the immune characteristics of two subtypes and aging-related prognosis genes in GC. The prognostic model established for three aging-related genes (IGFBP5, BCL11B, and AKR1B1) demonstrated good prognosis performance, providing a foundation for personalized treatment strategies aimed at GC.
Activity of Lignin-Modifying Enzyme of Selected Medicinal Mushrooms in Submerged Fermentation of Lignocellulosic Materials
Authors: Rusitashvili Mariam , Kobakhidze Aza , Elisashvili Vladimir I.
Published: January 2024

In the present study, wide diversity in the set and activity of lignin-modifying enzymes (LME) was revealed during submerged fermentation of mandarin peel with 15 strains of white rot Basidiomycetes. Among them, Trametes pubescens BCC153 was distinguished by the simultaneous production of laccase, manganese peroxidase (MnP), and lignin peroxidase (LiP). Supplementation of CuSO4 at a concentration of 1 mM in the media for the cultivation of four Trametes species manifold increased the production of laccase. The diverse effects of chemically different lignocellulosic growth substrates and nitrogen sources on the production of individual LME have been established. The maximum laccase activity of T. pubescens was observed when the fungus was cultivated on media containing mandarin peel and wheat bran, whereas the highest MnP and LiP activities were detected in the submerged fermentation of tobacco residue. Peptone and casein hydrolysate appeared to be the best sources of nitrogen to produce laccase and both peroxidases by T. pubescens BCC153 whereas KNO3 was the worst nitrogen-containing compound for the production of all enzymes.
Modular by necessity – Bracklinn Falls footbridge
Authors: Knight David , Brownlie Keith , Marks James , McKellar Murray , Boothman Danny
Published: January 2024

Bracklinn Falls is situated in a gorge surrounded by ancient woodland within the Loch Lomond and the Trossachs National Park. The park authority required a replacement footbridge to cross the gorge and to provide views of the falls. However, access for construction plant and materials was extremely difficult, with the sole access by way of a steep and sharp-cornered path. The construction and access constraints drove the development of a new modular system and governed the structural and aesthetic design for the new footbridge. The resulting structure consists of perforated panels, formed from single sheets of weathering steel folded into a z-shape. These panels were bolted to cross-frames and assembled to create a half-through beam that spans 21.4 m. The scheme achieved an A+ rating under the ‘structural carbon for bridges’ (SCORBs) system (Archer and Green, 2021). The structure was assembled bay by bay and push launched along a set of temporary rails, then jacked onto the permanent bearings. By using a folding process, the modular system minimised welding and hence fabrication time. The system is in the process of being developed for repeated use at other locations, and forms an attractive ‘flat-packed’ modular alternative for difficult to access locations.
Strengthening of slender webs of steel plate girders using FRP composites
Authors: Bhutto Muhammad Aslam , Rafi Muhammad Masood
Published: January 2024

Web buckling of steel plate girders creates an undesirable failure mode as it can limit the ultimate load capacity of plate girders. This paper presents details of an experimental investigation aimed at strengthening slender end panels of steel plate girders using three different types of fibre-reinforced polymer (FRP) composite materials (glass-fibre-reinforced polymer (GFRP) pultruded section stiffeners and woven carbon-fibre-reinforced polymer (CFRP) and GFRP fabrics). The plate girders were fabricated using non-rigid end posts and were tested in three-point bending. The test results showed an increase of up to 54% in the ultimate strength of the FRP-strengthened end panels compared with the non-strengthened control panel, which was the result of increased out-of-plane stiffness of the web. A breakdown of the bond between the steel and the FRP fabric occurred in the end panels strengthened with CFRP and GFRP fabrics, while no bond breakdown of the pultruded sections was observed at the ultimate load. Analytical methods proposed by some of the design codes underestimated the critical buckling load and overestimated the ultimate load of the non-strengthened end panel.
Harvesting electricity from road traffic noise energy – a literature review
Authors: Tanzadeh Rashid , Eskandari Torbaghan Mehran , Venetsaneas Nikolaos , Moghadas Nejad Fereidoon
Published: January 2024

Recent developments in digital technologies, including big data and internet of things concepts, have shown promising results in achieving more appropriate and effective pavement engineering through a proactive asset management approach. This could be achieved through an early diagnosis of defects and selection of an appropriate maintenance strategy informed by more granular data by the utilisation of advanced sensing systems. Such a sensing system for pavement, which should include a combination of embedded sensors and surface data sensors (e.g. cameras) would require electricity, which could be problematic when considering the growing demand for electricity around the globe. Harvesting electricity from the pavement, for example from traffic noise, which is the focus of this article, could bring new hope for achieving self-efficient and sustainable sensing systems for roads. If effective, an electricity generation system from road traffic noise could be counted towards the net zero carbon dioxide target set by road authorities. A review of the literature revealed that the noise of air pumping between the tyre and the pavement surface is the critical noise source with the highest potential for electricity generation. Harvesting, storage and conversion of noise energy to electrical energy are still in the preliminary stages.
cGAS Activation Accelerates the Progression of Autosomal Dominant Polycystic Kidney Disease
Authors: Yoo Miran , Haydak Jonathan C. , Azeloglu Evren U. , Lee Kyung , Gusella G. Luca
Published: January 2024

Significance Statement

The renal immune infiltrate observed in autosomal polycystic kidney disease contributes to the evolution of the disease. Elucidating the cellular mechanisms underlying the inflammatory response could help devise new therapeutic strategies. Here, we provide evidence for a mechanistic link between the deficiency polycystin-1 and mitochondrial homeostasis and the activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)/stimulator of the interferon genes (STING) pathway. Our data identify cGAS as an important mediator of renal cystogenesis and suggest that its inhibition may be useful to slow down the disease progression.

Background

Immune cells significantly contribute to the progression of autosomal dominant polycystic kidney disease (ADPKD), the most common genetic disorder of the kidney caused by the dysregulation of the Pkd1 or Pkd2 genes. However, the mechanisms triggering the immune cells recruitment and activation are undefined.

Methods

Immortalized murine collecting duct cell lines were used to dissect the molecular mechanism of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) activation in the context of genotoxic stress induced by Pkd1 ablation. We used conditional Pkd1 and knockout cGas

−/−
genetic mouse models to confirm the role of cGAS/stimulator of the interferon genes (STING) pathway activation on the course of renal cystogenesis.

Results

We show that Pkd1-deficient renal tubular cells express high levels of cGAS, the main cellular sensor of cytosolic nucleic acid and a potent stimulator of proinflammatory cytokines. Loss of Pkd1 directly affects cGAS expression and nuclear translocation, as well as activation of the cGAS/STING pathway, which is reversed by cGAS knockdown or functional pharmacological inhibition. These events are tightly linked to the loss of mitochondrial structure integrity and genotoxic stress caused by Pkd1 depletion because they can be reverted by the potent antioxidant mitoquinone or by the re-expression of the polycystin-1 carboxyl terminal tail. The genetic inactivation of cGAS in a rapidly progressing ADPKD mouse model significantly reduces cystogenesis and preserves normal organ function.

Conclusions

Our findings indicate that the activation of the cGAS/STING pathway contributes to ADPKD cystogenesis through the control of the immune response associated with the loss of Pkd1 and suggest that targeting this pathway may slow disease progression.
Manifestaciones bucales de la inmunodeficiencia: revisión integrativa de la literaria
Authors:   Universidad de Cartagena, Porto-Puerta Iván , Diaz-Caballero Antonio ,   Universidad de Cartagena, Martínez-Martínez Adel ,   Universidad de Cartagena
Published: January 2024

Introducción: la inmunodeficiencia es la alteración funcional del sistema inmunológico, la cual es causada por factores congénitos o secundarios. Esta disfunción suele generar no solo manifestaciones sistémicas, sino también a nivel de cavidad bucal y zona peribucal. Objetivo: identificar y explicar las manifestaciones bucales de la inmunodeficiencia según la literatura. Metodología: se realizó una revisión integrativa de la literatura, los documentos fueron identificados mediante la búsqueda en bases de datos de alto impacto; se seleccionan in-vestigaciones originales, casos clínicos, revisiones literarias y libros. No se aplicaron restricciones en el idioma ni en el tiempo de publicación. Resultados: Entre las manifestaciones bucales más reportadas se encuentran, la candidiasis bucal, lesiones ulcerativas, Condiloma acuminado, leucoplasia vellosa y enfermedades perio-dontales necrosantes. Conclusiones: debido a que los sujetos inmunodeficientes tienen mayor susceptibilidad de padecer diversas afecciones que podrían poner en riesgo su vida; se considera fundamental la identificación temprana de las manifestaciones bucales que permitan facilitar el diagnóstico sistémico de la afección inmune además de permitir un tratamiento concomitante de la manifestación estomatológicas y sistémicas.
Efeito da qualidade da informação e da integração eletrônica interna sobre a gestão interna de custos e o desempenho organizacional
Authors: Poffo Rubia Frehner , Bubeck Stephan Klaus , Lunardi Micheli Aparecida
Published: January 2024

A integração eletrônica interna proporciona a integração dos dados para as organizações. É por meio dela que as organizações obtêm informações sobre os custos de produção, que por sua vez permitem à empresa ter um desempenho superior no mercado. Nesse contexto, esta pesquisa tem como objetivo analisar o efeito da qualidade da informação sobre a gestão interna de custos e seus reflexos no desempenho organizacional. Esta pesquisa foi desenvolvida de forma descritiva, por meio do levantamento de dados com 99 respondentes, que compreendem profissionais nos cargos de coordenador, analista sênior, gestores e supervisores de custos de empresas brasileiras. Para a mensuração dos dados foi utilizada a análise quantitativa e equações estruturais por meio do software SmartPLS 4. Os principais achados desta pesquisa demonstram que organizações que possuem integração eletrônica interna entre os departamentos da empresa possuem informações que proporcionam uma melhor gestão interna de custos. Esses resultados se justificam, visto que as informações de qualidade permitem aos profissionais efetuarem uma análise mais detalhada dos gastos na organização, possibilitando a diminuição dos custos organizacionais. Assim, informações corretas e em tempo real permitem aos gestores tomarem decisões que resultam no incremento do desempenho organizacional, assim como uma maior compreensão dos processos internos que envolvem as linhas de produção. Este estudo contribui ao apresentar novos insights sobre a percepção que profissionais da área de custos possuem a respeito das relações investigadas na pesquisa. Também contribui para as decisões e estratégias adotadas pelo gestor para gerenciar seus custos e elevar o desempenho da empresa.
On [V] on v
Authors: Ilkhanipour Negin
Published: January 2024

Based on the expression of temporality in the nominal domain and its syntactic representation via the functional projections of Nominal Tense and Nominal Aspect, this article argues against the proposal that an extending-into-time perspective distinguishes the categorial feature [V] on little v from [N] on little n at LF. It demonstrates that supralexical causation, instead of temporality, is the necessary interpretive perspective encoded in [V] on v and that little n and Voice do not share the causal nature of v. The force theory of causation is then employed to define causation in terms of a causal mechanism (i.e., a configuration of forces and a position vector). The force-theoretic approach to the causal nature of v explains how different flavors of this categorizer, that is, vCAUSE, vBECOME, vDO and vBE, refer to different patterns of force and position vectors in the causal apparatus provided by [V] on v.
Evaluation of COVID-19 anxiety level and COVID-19 vaccine acceptance of the Turkish citizens during the pandemic period
Authors: Pelin Yıldırım , Cemal Kavasoğulları , Cumali Uri , Rabia Kılaç , Ersin Akpınar
Published: January 2024

Aim: In this work, we try to determine the effect of the coronavirus disease of 2019 (COVID-19) on Turkish citizens’ anxiety levels and we try to investigate the COVID-19 vaccine acceptance rate among citizens. Moreover, the aforementioned two statistics are cross-correlated with each other. As final work, the reasons for the objection to the COVID-19 vaccine are observed. Method: The survey was conducted on October 5, 2020, the survey link for the research was made available for participation to all adults aged 18 and over throughout Turkey through various media channels and social media platforms (WhatsApp, Instagram, Facebook). Data was collected via an online survey for 27 days, and the target sample was reached using the snowball method, concluding data collection on November 1, 2020. The survey data is analyzed by the Statistical Package for the Social Sciences (SPSS) programs. Results: The mean age was 36.47 ± 12 years and 62% (1260) were women of the 2032 participants. COVID-19 vaccine behavior (COVID-B) was reported as 3.52 ± 1.0 (min 1, max5). 51.3% of the respondents were positive for the vaccination. 20.9% of the participants were completely positive for the vaccination. The most relevant (with 27.9%) reason for the hesitation is the safety of the vaccination. Furthermore, vaccine positivity was reported as proportional to the safety concerns about the COVID-19 pandemic (r = 236). Conclusion: The report shows us that the rate of anxiety due to COVID-19 is related to the education level, which states that social awareness of the pandemic increased with the education level. However, there is no significant relationship between education level and COVID-19 vaccine acceptance. The most related factor to vaccine acceptance was the concern level of the people. We can say that the vaccine rate could be increased with knowledge of the pandemic.
Initial development of Cotlin island south shoreline
Authors: Granstrem Maria A.
Published: January 2024

The article considers the initial stages of developing the coastline of Kotlin Island in the first half of the 18th century. The construction of a unique system of fortifications and engineering structures and harbors for military and merchant ships was carried out according to the plan and under the leadership of Peter I. The oldest forts, the walls of the first Kotlin’s harbors, the initial docking channel, and the Italian pond were organized with the direct participation of the emperor in the period from 1704 to 1725. In the course of research, the author discovered archival materials that had not previously been introduced into scientific circulation. The article is published based on the results of a historical and cultural expertise along the southern coastline of Kotlin Island, aimed at identifying and preserving cultural heritage objects - coastal walls of harbors, fortifications and engineering structures.
Types of residential buildings and their influence on the class of housing and on the formation of a comfortable urban residential environment
Authors: Generalov Viktor P. , Generalova Elena M.
Published: January 2024

The article touches upon the problem of creating a comfortable, convenient urban living environment by incorporating into the structure of urban development space-planning solutions for residential buildings and complexes that are new to Russian conditions, including multifunctional ones with a rich social infrastructure. The active introduction of residential buildings and serviced residential complexes into the living environment forms the modern level of the living environment, improves the quality and comfort of living by including the required number of service elements in their space-planning structure. It is noted that the most rational placement of service elements is their integration into stylobate parts, as well as into the first and underground floors of residential buildings or complexes. Buildings and complexes that differ in the degree of saturation with service elements form new approaches to solving problems associated with both the development and classification of a “housing class” and the creation of a comfortable, convenient, high-quality urban residential environment. When developing and determining the “housing class”, it is proposed to take into account the influence of the main space-planning elements at the level of an apartment, floor, section, building or complex, courtyard space and residential area as a whole as the main factors forming the “standard class”, “comfort class”, “business class” and “elite class”.
The significance of architectural, technological and environmental aspects in building environmental certification systems
Authors: Sukhinina Elena A.
Published: January 2024

The criteria for environmental standards in construction include requirements for organizing a sustainable territory, reducing the consumption of water and energy resources, using environmentally friendly materials, rational waste management, and creating a favorable microclimate for users. The main goal is to study architectural, technological and environmental aspects in international (LEED, BREEAM) and Russian (GOST R 70346-2022, GOST R 54964-2012, KLEVER, GREEN ZOOM) systems that influence the formation of the architectural environment in Russian cities. The research methodology used is complex with mathematical analysis of requirements and their comparison. The distribution of criteria is not balanced. Engineering and technological activities predominate. It is necessary to increase the criteria for environmentally friendly architectural and planning solutions. The role of the architect in the certification of the object should be increased.
Creative solution concept for urban structure sustainability development (for example: architecture and planning structure of Iranian small cities)
Authors: Kashiripoor Mohammad Mahdi
Published: January 2024

Special urgency for small cities in Iran represents developing problem guiding principles of transformation and development of architectural and planning structure, as well as applied technique of its evaluation in accordance with the requirements of sustainable development. This article describes leading forms of urban development settlements and identifies common principles which influence on sustainable urban development.
The objective of this article is to assert sustainable development theories which meets city planning structure and develop a sustainability concept for Iranian small cities. This will be done through studies that were influenced by addressing a rethinking in order to emphasize adapting new trend of sustainable development which focused on city planning structure, and suitable for Iranian small cities condition. Thus, the main tasks of study could be formulated as follows: define Iranian small cities planning structure features and problems; study recent sustainability documents and related urban development forms and principles; comparative analysis; and finally suggest a creative solution for architectural and planning structure for Iranian small cities condition.
The research used the method of analysis of latest international scientific literature and documents related to urban development sustainability in order to evaluate, compare and achieve a proper solution for Iranian small cities structures sustainability. It should be noted that such kind of analysis would be done only after analyzing and identifying the features and problems of the planning structure of Iranian small cities.
Results of study: The article reveals recent sustainable urban development forms and its interpretations in modern urban development theories; demonstrates Iranian cities structure features; Iranian cities general plans problems; urban forms and design principles for achieving the goals of sustainable urban development for conditions of Iran.
The scientific novelty of research is to study recent urban sustainable development forms and principles which related to urban structures; and suggest an appropriate and suitable concept for Iranian small cities development sustainability.
OUTLOOK BASIC OF "GARDEN OF GOD SONGS" OF HRYHORII SKOVORODA
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Slipushko O. М. , Fan R. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Huan M. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: January 2024

In this article the fundamental outlook basic of poetical book “Garden of God songs” of Hryhorii Skovoroda is investigated. It is underlined the new character of formation of modern methods of poetic representation, partly poetic. It is represented understanding and interpretation by Skovoroda of difficult and important philosophical categories. It is underlined the formation by poet individual symbols, allegories and metaphor. It is analysed the join it his outlook the Ancient, Middle Ages and Renaissance traditions. The outlook basic of book “Garden of God Songs” is characterised as Baroque. The general symbols in the art outlook of Hryhorii Skovoroda is mirror, way, nom, snake, stone, circle, sea, plant, garden, theatre. Symbols and emblems of poetic texts represent his Baroque outlook, that was formed in the basic of Bible, Ancient traditions and philosophical thinking. Poetic texts of book and its ideas in this book represented its connection with European literature traditions. That is why we can analysed literary heritage of writer in the context of the world literature and philosophy. In general in book of Hryhorii Skovoroda “Garden of God songs” we can observe the Baroque complicate art conception and outlook system. The outlook context is based on the reinterpretation of Middle Ages and Renaissance traditions. The text of author represent the interpretation of Bible texts and Ancient culture. These two equal sources for inspiration and looking texts. The outlook system of Skovoroda is represented through reading not only exterior text but interior text too. Author formed individual interpretation model interpretation model of outlook thinking. It is presented through system of art images with Baroque character.
The bain and orthorhombic paths of the bcc–fcc transformation in a bcc metal
Authors:   M. N. Mikheev Institute of Metal Physics, Ural Branch of the Russian Academy of Sciences, Kuznetsov A. R. , Starikov S. A. ,   M. N. Mikheev Institute of Metal Physics, Ural Branch of the Russian Academy of Sciences
Published: January 2024

The energy of the Bain and orthorhombic paths in niobium and the instability of phonons during uniaxial deformation along <001> are studied with the application of the ab initio method. The orthorhombic transformation path is refined with regard to its symmetry. The calculation of the phonon spectrum in the entire irreducible Brillouin zone depending on deformation makes it possible to find the softest branches of the phonon spectrum responsible for the loss of stability of the structure. The nature of the loss of stability is revealed, and the strain at which stability is lost both in tension and compression is evaluated. Possible mechanisms determining the stability of the structure and theoretical strength of niobium are discussed. The results obtained can relate to experimental situations when small defect-free regions are deformed, for example, in nanostructured materials, when surface layers are modified by modern methods of plastic deformation, and during nanoindentation.