bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical modeling of the process of the injection of carbon dioxide into a formation containing methane and its hydrate
Authors: Musakaev N.G. , Borodin S.L. , Belskikh D.S.
Published: August 2024

Recently, special attention is paid to the development of deposits of natural gas hydrates due to their wide distribution in nature and the large reserves of hydrocarbons contained in such deposits. The article discusses an innovative gas extraction method based on the injection of carbon dioxide into a gas hydrate formation. This technology makes it possible to accumulate greenhouse gases in solid gas hydrate form at very low economic costs, as well as solve the problem of natural gas extraction. A mathematical model of non-isothermal filtration of carbon dioxide in the gaseous state, methane and water is constructed based on methods and equations of mechanics of multiphase media considering the replacement of methane in the gas hydrate with carbon dioxide to obtain predictive calculations. The model additionally takes into account such important factors as filtration flow of water and gas, real gas properties, Joule–Thomson and adiabatic compression effects; the process of CH4 –CO2 replacement in gas hydrate is assumed to be equilibrium. The equations are presented to calculate the values of the main process parameters (pressure, temperature, mass fraction of gas phase components, phase saturations, etc.) in one-dimensional radial axisymmetric approximation. Discrete analogues of differential equations are written down and an algorithm for numerical solution of the proposed mathematical model is given. Calculation of saturation distributions of methane and carbon dioxide hydrates is carried out considering their phase equilibrium at current values of pressure, temperature and water saturation. Numerical solutions are constructed that describe the distributions of pressure, temperature, mass concentrations of gas phase components and saturations of methane and carbon dioxide hydrates in the reservoir for the problem of injecting carbon dioxide into a reservoir initially saturated with methane and its hydrate.
Machine Learning Prediction and Simulation of Drugs Targeting GSK-3β in Breast Cancer
Authors: Munieswaran Gayatri , Subramani Nandha Kumar , Venugopal Subhashree
Published: August 2024

Introduction and Objective:

Breast cancer ranks as the second-most prevalent cause of
death among women worldwide, with particularly elevated mortality rates in India. Breast cancer’s
origin involves biochemical pathway alterations influenced by tumor-inducing proteins. Research
has highlighted glycogen synthase kinase-3 beta (GSK-3β) as a crucial protein that regulates
the expression of various genes in the cell cycle. Mutations in this protein have a significant
impact on cellular development. As a consequence, it triggers aggressive subtypes of breast cancer,
such as triple-negative breast cancer. So, the primary aim of this study is to identify novel
chemicals targeting GSK-3β using machine learning methods, molecular modeling, and dynamic
techniques.

Materials and Methods:

To achieve the study's objective, small molecules were screened using a
Machine Learning (ML) approach, and subsequently, molecular docking and dynamic modelling
investigations were conducted to explore interactions between drugs and GSK-3β.

Results:

The research findings highlighted a specific compound, piperidine, 4-(3,4-
dichlorophenyl)-4-[4-(1H-pyrazol-4-yl) phenyl], which exhibited a superior docking score of -9.6
kcal/mol. Piperidine also formed conventional hydrogen bonds with the target protein. Furthermore,
the calculated binding free energy of -12.46 kcal/mol suggested that this compound exhibited
greater stability compared to commercially available drugs.

Conclusion:

These promising findings highlight the potential of piperidine and similar small
molecules as promising candidates for targeting the tumor-inducing protein GSK-3β. Subsequent
investigations, both in vitro and in vivo, will be essential to assess their effectiveness in combating
breast cancer.
Long-Term Use of Metformin and Vitamin B12 Deficiency in Diabetes
Authors: Hussain Md Sadique , Srivastava Nitya , Singh Gurvinder , Kumar Rajesh
Published: August 2024

This extensive review delves into the complex relationship between prolonged use of
metformin and the possible emergence of vitamin B12 deficiency (VB12D) in diabetic patients.
Metformin, a pivotal element in diabetes management, is constantly linked with decreased absorption
of vitamin B12, prompting concerns about the enduring consequences of this interaction.
The review systematically amalgamates current evidence, elucidating the prevalence,
mechanisms, and clinical ramifications of VB12D induced by consistent consumption of metformin.
Exploring the different pathways through which metformin might disrupt the absorption
of Vitamin B12, the review encompasses interference with the calcium-dependent membrane activity
and alterations of the microbiota present in the gut. A meticulous analysis of experimental
studies and human trials is undertaken, accentuating the prevalence of variable VB12D among
individuals on long-duration treatment of metformin across diverse populations and age groups.
Clinical indications of cobalamin deficiency, spanning haematological abnormalities to neurological
complications, are systematically examined. Furthermore, the review delves into the potential
implications of cobalamin deficiency associated with metformin on diabetes-related complications
and overall patient health. This review offers a comprehensive overview of the intricate
interplay between the use of metformin and deficiency of vitamin B12 in diabetic patients,
emphasizing the importance that lies in routine monitoring, early detection, and personalized interventions
to optimize the long-period safety and efficiency of metformin in the treatment of diabetes.
It also proposes future research directions to refine clinical guidelines and enhance the
understanding regarding the correlation between diabetes, metformin, and vitamin B12.
The Protective Effects of Mito-TEMPO on Acetaminophen-induced Hepatotoxicity: A Systematic Review
Authors: Jamshidi Hamid Reza , Saadati Mahdi , Saghafi Fatemeh
Published: August 2024

Background:

Acetaminophen overdose is a leading cause of acute liver failure glob-ally. Current treatment options, primarily N-acetylcysteine (NAC), have limitations. Mito-TEMPO (Mito-T), a mitochondria-targeted antioxidant, has shown potential in preclinical stud-ies. This systematic review evaluated the evidence for Mito-T's hepatoprotective effects against acetaminophen-induced liver injury.

Methods:

We conducted a comprehensive search of databases and grey literature following PRISMA guidelines. Studies published between 2000 and 2023 on Mito-T and acetaminophen-induced hepatotoxicity in animal models were included. Data on study characteristics, inter-ventions, outcomes, and risk of bias were extracted.

Results:

Six high-quality studies were included. Mito-T administration significantly reduced serum alanine transaminase (ALT) levels, a marker of liver injury, compared to controls. Mito-T also protects against hepatocellular necrosis, apoptosis, and mitochondrial dysfunction. These effects were likely mediated by Mito-T's ability to scavenge reactive oxygen and nitrogen spe-cies within mitochondria.

Conclusion:

This review provides strong evidence that Mito-T effectively protects against ac-etaminophen-induced liver injury in animal models. Mito-T’s mechanisms of action address a critical pathophysiological pathway in acetaminophen toxicity. While limitations, including the use of animal models and potential for publication bias, exist, the findings suggest Mito-T holds promise as a novel therapeutic option. Further studies are needed to assess Mito-T's safety, pharmacokinetics, and optimal dosing in humans. Clinical trials comparing Mito-T against NAC are warranted if toxicity profiles are favorable. Additionally, investigating Mito-T's po-tential in other diseases involving oxidative stress is crucial.
THE COMPETITIVENESS OF LABUAN BAJO WITH SENTIMENT ANALYSIS
Authors: Adicatra Dayu Cakasana , Dias Satria
Published: August 2024

TripAdvisor is one of the popular websites that collects various traveler reviews of tourism place that have been visited by its users. Reviews are important factors that influence the decision or motivation of a tourist to go to a tourism place. Labuan Bajo is one of the tourism sites that have been given a lot of reviews on TripAdvisor. Looking at this aspect, this study utilized the reviews of foreign tourists to increase competitiveness and economic activity atLabuan Bajo. Research data were obtained directly from the internet using data mining methods for later analysis. This study employed sentiment analysis method. The results of sentiment analysis in this study are information and suggestions for improving the competitiveness and economic activities of Labuan Bajo to be better.
PREFERENSI MUSLIM TERHADAP PEMBELIAN PRODUK MAKANAN IMPOR BERSERTIFIKASI HALAL DI KOTA MALANG
Authors: Al Muqaffi Dzakka
Published: August 2024

Being the country with the most Moslem population in the world, Indonesia has a variety of halal foods that can be addressed to its consumers. This is a distinct advantage for both local and foreign economic actors. With a large population, of course, foreign businessmen are also interested in exporting their products to Indonesia, including food products. With the development of technology, it can affect a person's lifestyle where everyone can access social media easily. With the existence of social media, sellers will find it easier to advertise their products so that it can lead to increased consumer demand. Imported food itself is being favored by many people today, although local food can also compete there. As a Moslem, of course, the halalness of a product is the main thing to look at before buying a product. In this case, the Moslem's is guaranteed by the 1945 Constitution. Therefore, the state is also responsible for and guarantees the halalness of products consumed by Moslems in Indonesia. This study aims to determine the factors that influence Moslem preferences for purchasing halal-certified imported food products in Malang City. The analysis used is descriptive statistical analysis with logistic analysis method. The results of this study indicate that there is a simultaneous significant effect between the independent variables on the dependent variable. Meanwhile, partially, only one independent variable has a significant effect on the dependent variable, namely the price variable.
FAKTOR-FAKTOR YANG MEMPENGARUHI PREFERENSI MAHASISWA EKONOMI ISLAM UNTUK BEKERJA DI LEMBAGA KEUANGAN SYARIAH
Authors: Bagus Johan , Khusnia Anggraini Ika
Published: August 2024

The existence of this study aims to determine whether there is influence from knowledge of Islamic finance, spiritual motivation, and financial rewards on the preferences of Islamic economics students to work in Islamic financial institutions. This research only focuses on students of Islamic economics, Faculty of Economics and Business, Universitas Brawijaya, class of 2014-2019. This study uses a quantitative approach where data is obtained through a questionnaire using a Likert scale. There were 90 sample respondents consisting of 49 male respondents and 41 female respondents. Data testing was carried out using the help of SPSS software, the method applied was multiple linear regression analysis. The results of the study show that knowledge of Islamic finance and spiritual motivation have an influence on preferences for working in Islamic financial institutions. Meanwhile, financial income has no effect on preferences to work in Islamic financial institutions. Meanwhile, knowledge of Islamic finance, spiritual motivation, and financial rewards explains 45.1% of the preference for working in Islamic financial institutions.
PENGARUH PENDAYAGUNAAN ZAKAT PRODUKTIF TERHADAP KESEJAHTERAAN MUSTAHIK PADA PROGRAM UNIT USAHA EKONOMI KELUARGA
Authors: Ghifar Muhammad Dzil , Prestianawati Silvi Asna
Published: August 2024

Zakat has the potential to be an effective means of empowering the people's economy. Seeing from the majority of Indonesia's population, the majority adheres to Islam. The large number of Indonesians who embrace Islam is 87.2% or around 207,176,162 people of all religions recognized in Indonesia. The main weakness of mustahik to be able to start a small business is actually the mental attitude and readiness of business management. For this reason, giving zakat with the aim of starting a productive business at the initial stage must be accompanied by a companion who is able to educate mustahik. This study aims to analyze the role of utilization of productive zakat on the welfare of mustahik in the Family Economic Business Unit program at the Amil Zakat Infaq Shadaqah Muhammadiyah Institute. This research was conducted at Parepare in April 2023 involving 30 respondents who were selected using a non-probability sampling technique. Data analysis was performed using multiple linear regression methods. The results of this study indicate that the variable of business capital received has a significant effect on the welfare of mustahik, the variable of distribution of zakat has a significant effect on the welfare of mustahik, and the variable of utilization of zakat has a significant effect on the welfare of mustahik
PENGARUH PEMBERDAYAAN DANA ZAKAT PRODUKTIF SEBAGAI MODAL USAHA UMKM TERHADAP KINERJA UMKM (Studi pada BAZNAS)
Authors: Fikri Charfian Hadi Pratama Kusuma  , Iswan Noor
Published: August 2024

This study aims to determine the factors that influence the performance of MSMEs in Tanah Abang, Central Jakarta in 2022. The research data was obtained by distributing questionnaires to mustahiq productive zakat recipients. Human Resources performance variable in MSMEs as the dependent variable. The variable Provision of Productive Zakat Funds, Productive Zakat Fund Management System, and Productive Zakat Fund Utilization System as independent variables. This study uses data analysis methods in the form of Classical Assumption Tests and Multiple Linear Regression Tests. The results of this study indicate that partially, the variables X1, X2, and X3 have no significant effect on Y. Meanwhile, simultaneously, the variables X1, X2, and X3 significantly affect Y.
PREFERENSI KEPUTUSAN MEMBAYAR ZAKAT, INFAQ, SEDEKAH DI LEMBAGA AMIL ZAKAT MELALUI PEMBAYARAN DIGITAL
Authors: Nabilah Ulfa , Galuh Ajeng Kartika
Published: August 2024

The high number of Muslim population and the potential for Zakat, Infaq and Alms (ZIS) in Indonesia do not reflect the collection of ZIS in Indonesia by the Amil Zakat Institution (LAZ). Efforts to maximize ZIS collection by LAZ require innovation in the form of digital payment methods. The purpose of this research is to find out the preferences of muzakki in channeling ZIS funds through digital payments to LAZ based on LAZ's reputation in the community, the ZIS distribution program to mustahiq, the convenience offered on LAZ digital payments, and the digital ZIS payment method by muzakki. The method in this study is quantitative by using logistic regression data analysis. The results of this study partially LAZ reputation variables and digital ZIS payment methods have a significant and positive effect on the decision to pay ZIS through digital payments. Simultaneously the LAZ reputation variable, ZIS distribution program, convenience, and digital ZIS payment methods have a significant effect on the decision to pay ZIS through digital payments. So, from this research it can be seen that muzakki's trust and the development of digital payment technology offered by LAZ have influenced muzakki's interest in paying ZIS at the LAZ.
FAKTOR-FAKTOR YANG MEMENGARUHI KEPUTUSAN PEMBELIAN PRODUK REKSADANA SYARIAH DI APLIKASI BIBIT
Authors: Aliifah Shofi , Galuh Ajeng kartika
Published: August 2024

Both in terms of quantity and NAV based on the OJK report as of August 2022, the level of sharia mutual funds is still relatively low in comparison to conventional mutual funds. According to KSEI data as of June 2022, investors primarily belong to the millennial and Z generations. This is a result of how convenient financial technology has made investing, and one of Indonesia's most well-known investment businesses is Bibit. This study aims to identify the elements that millennial and Z generations use to decide whether to buy sharia mutual fund products using the Bibit application. In this quantitative study, 96 individuals who have acquired Islamic mutual fund products range in age from 17 to 40. According to the findings of logistic regression research, financial capability, returns, and Islamic financial literacy simultaneously have an impact on consumers' purchasing decisions. Partially, Islamic financial literacy and ability have no discernible impact, whereas return has a positive and significant impact. As a result, it is known that return is the primary factor in millennial and Z generations' decisions to purchase Islamic mutual fund products through the Bibit application.
PERUBAHAN PERILAKU KONSUMSI PADA MASYARAKAT JAWA TIMUR SELAMA MASA PANDEMI COVID-19
Authors: Arina Sofi Ulya  , Dwi Budi Santoso
Published: August 2024

The COVID-19 pandemic that occurred in various countries affected almost all aspects of life, one of which was community activities. The existence of social restriction policies has a direct impact on the decline of economic activity, which has the opportunity to change people's consumption behavior. Consumption behavior is the activity of spending income to maximize utility. This study aims to determine changes in consumption behavior in the people of East Java during the COVID-19 pandemic. The method used is a classy typology model to see changes in consumption in 2019 and 2020. Then, it was analyzed using the COVID-19 risk index in each region. The results showed that the changes in consumption that occurred in East Java were influenced by the COVID-19 risk index, areas that have a high risk index tend to experience changes in consumption and vice versa. The changes in behavior that occur due to covid-19 risk factors vary in each region so that changes occur in the proportion of consumption of goods/services and changes in savings rates. This research can assist the government in taking economic recovery policies after the COVID-19 pandemic in each region by looking at the COVID-19 risk index.
ANALISIS EFISIENSI PENGELUARAN PUBLIK TERHADAP PEMBANGUNAN MANUSIA DENGAN METODE STOCHASTIC FRONTIER ANALYSI
Authors: Katlea Rizki Nabilah  , Dwi Budi Santoso
Published: August 2024

The role of the Government in improving the quality of human development isfrom the fiscal capacity provided, one of which is from the per capita APBD. Thehighpercapita APBD anticipates human development expectations. East Java Provincewitharelatively higher per capita APBD than Indonesia's APBN per capita, has aHumanDevelopment Index (HDI) figure below the national average. Therefore, this studyisapublic expenditure of the East Java regional government with education and healthindicesas outputs. On the other hand, data on the Audit Results Report (LHP), the PerformanceAccountability System for Government Agencies (SAKIP), economic growth, andpercapitaincome are used to see the characteristics of an ef icient region. Datafrom38districts/cities of East Java during 2018-2020 were collected to conduct this research.Stochastic Frontier Analysis (SFA) is used to measure the level of ef iciency. Inaddition,ef icient regional characteristics are also measured using cluster analysis and scoring. Theresults of the SFA and cluster analysis show that there are 25 districts/cities withhigh-ef iciency levels that have performed ef iciently for at least 2-3 years. The resultsof thecluster analysis show that regions with high ef iciency have conditions of growthandincreased economic activity, and are orderly in budget management and planning. Ontheother hand, it can be concluded that the main indicators of the highest ef iciencyineducation and health are regions with orderly financial planning and development.
PENGARUH RASIO LIKUIDITAS, RASIO PROFITABILITAS, RASIO MANAJEMEN UTANG, DAN RASIO AKTIVITAS TERHADAP RETURN SAHAM
Authors: Nagari Rosalia Septia , Yuana Pusvita
Published: August 2024

The purpose of this study is to analyze the effects of liquidity ration profitability ratio, debt management ratio, and activity ratio on stock return. This explanatory research uses quantitative approach in explaining the relationship of a variable with the others. Secondary data compiled from the annual reports of food and beverages companies listed on the Indonesia Stock Exchange was used in this research. Using purposive sampling technique, nine companies that meet the criteria were selected as the sample. The hypotheses were tested based the multiple linear regression analysis. The independent variables in this study are liquidity ratio that was measured using Current Ratio (CR), profitability ratio that was measured using Return on Assets (ROA), debt management ratio that was measured using Debt-to-Equity Ratio (DER), and activity ratio that was measured using Total Assets Turnover (TATO). The dependent variable is stock return. This study finds that, in partial ways, there are insignificant effects of financial performance that was measured using CR, DER, and TATO on stock return and that there is a positive and significant effect of financial performance that was measured using ROA on stock return.
IMPLEMENTASI GOOD CORPORATE GOVERNANCE DALAM UPAYA MENINGKATKAN KINERJA PERUSAHAAN
Authors: Putri Erika Priscilla , Pradana Bayu Ilham
Published: August 2024

The objective of this research is to identify the implementation of good corporate governance at PT. ASABRI (Persero) branch office of Surabaya in the effort of enhancing their performance. Here the company serves as the research object. The data was harvested through interviews, observations, and documentations and was analyzed using Miles-Huberman interactive analysis. This study finds that, in order to improve their performance, the company has well implemented good corporate governance principles consisting of accountability, responsibility, independency, and fairness. However, transparency has not been optimal since the branch office is merely a user; the manager is the head office. The well implementation of good corporate governance can increase the company’s performance and their image for the people.
ANALYSIS OF BANKING FINANCIAL PERFORMANCE BEFORE AND WHILE THE PANDEMIC ERA USING RISK PROFILE, GOOD CORPORATE GOVERNANCE, EARNINGS, AND CAPITAL (RGEC) METHOD
Authors: Safira AM Zia , Yuana Pusvita
Published: August 2024

This study aims to determine the level of bank soundness at PT Bank CIMB Niaga Tbk during the 2018-2021 period i.e 2 years before and 2 years while the pandemic era of COVID-19 using the RGEC method (Risk Profile, Good Corporate Governance, Earning, and Capital). This research is measured through several financial ratios, including NPL, LDR, GCG by Self-assessment, ROA, NIM, and CAR. This study uses a quantitative-descriptive type of research through secondary data obtained by the documentation method in the form of annual financial reports which are accessed through the official website of PT Bank CIMB Niaga Tbk and credible institutions. The results of this study indicate that the condition of PT Bank CIMB Niaga Tbk before and while the pandemic era of COVID-19 2018-2021 on average in risk profile with NPL got a level of 2 which means healthy. LDR was level 2 which means healthy, GCG got a level of 1 which means very healthy, earnings with ROA ranked as 2 which means healthy, NIM ranked as 1 which means very healthy, and capital with CAR ranked as 1 which means very healthy. All results generally obtained a composite level of 2 which means healthy. Although several aspects of the assessment were found with the soundness of the bank at the composite level of 3 during the pandemic of COVID-19, this did not affect the final result of the soundness of the bank.
PENGARUH FINANCIAL LEVERAGE TERHADAP PROFITABILITAS PERUSAHAAN
Authors: Sabrina Lutva , Salim Ubud
Published: August 2024

The objective of this quantitative explanatory study is to identify the capability of property, real estate, and construction building companies to produce profitability using debt. Using total sampling, in which all members of the population are selected, 17 companies listed on the Indonesia Stock Exchange in the 2017-2019 period were selected as the sample. This research uses three independent variables and independent variable. The independent variables are Debt-to-Asset Ratio, Debt-to-Equity Ratio, and Time Interest Earned Ratio, while the dependent variable is Return on Equity. The data analysis was conducted using multiple linear regression in SPSS. This study finds that Debt-to-Asset Ratio has no significant influence on Return on Equity, that Debt-to-Equity Ratio has no significant effect on Return on Equity, and that Times Interest Earned Ratio has significant impacts on Return on Equity.
DEVELOPMENT OF COMMUNICATION STRATEGY FOR ENHANCING PUBLIC AWARENESS OF TUBERCULOSIS
Authors:   Departemen Keperawatan, Fakultas Ilmu Kesehatan, Universitas Brawijaya, Wihastuti Titin Andri , Utami Yulian Wiji ,   Departemen Keperawatan, Fakultas Ilmu Kesehatan, Universitas Brawijaya
Published: August 2024

Tuberculosis (TB) remains a significant global health issue, particularly in Indonesia, where lack of awareness and knowledge about TB hinders efforts to control its spread. In the Manggarai region, Nusa Tenggara Timur, the geographical diversity and limited infrastructure further complicate health education efforts. This community service activity aimed to increase awareness, knowledge, and understanding of TB among the Manggarai community through effective communication strategies. Method: The initiative involved a collaboration between the Faculty of Health Sciences Universitas Brawijaya (FIKES UB) and the Manggarai Health Office. The methods included conducting a Forum Group Discussion (FGD) to analyze the situation, followed by four hybrid sessions of communication training, distribution of TB-themed merchandise, and ongoing monitoring and evaluation. Result: The activities led to a noticeable improvement in community awareness, knowledge, and understanding of TB. Additionally, several key barriers to TB control in the region were identified and addressed through this initiative. Conclusion: The program successfully enhanced TB awareness, knowledge, and understanding in Manggarai, highlighting the importance of targeted communication strategies in overcoming health education challenges in regions with limited infrastructure.
Cost Benefit Analysis Management of Jerry Can Hemodialysis Used Packaging of Hazardous and Toxic Substances In The Islamic Hospital Surabaya
Authors: Hanifah Putri Alfiani Nur
Published: August 2024

Pengelolaan jirigen hemodialisa di Rumah Sakit Islam Surabaya secara pengangkutan dan pemusnahan terjadi kenaikan nilai kontrak sebesar 50% dan tidak efisien untuk dilanjutkan. Dengan adanya penawaran untuk pengelolaan jirigen hemodialisa secara Reduce, Reuse, Recycle (3R) maka penelitian ini bertujuan untuk menganlisis biaya dan manfaat (cost benefit analysis) pada pengelolaan jirigen hemodialisa pengangkutan dan pemusnahan dan pengelolaan jirigen hemodialisa secara Reduce, Reuse, Recycle (3R). Penelitian ini menggunakan metode cost benefit analysis yang merupakan penelitian kuantitatif dan bersifat observasional. Dari hasil perhitungan masing – masing pengelolaan jirigen hemodialisa didapatkan hasil Present Value (PV) cost untuk pengelolaan jirigen hemodialisa pengangkutan dan pemusnahan sebesar Rp. 268.326.525 sedangkan PV cost pengelolaan jirigen hemodialisa reuse, reduce, recycle sebesar Rp. 32.159.233. Untuk PV benefit pengangkutan dan pemusnahan adalah Rp. 0 dan PV benefit 3R adalah 97.015.367. Ratio B/C pengelolaan jirigen hemodialisa pengangkutan dan pemusnahan adalah 0 dan Ratio B/C secara 3R adalah 3,02. Berdasarkan nett present value diperoleh pengangkutan dan pemusnahan sebesar Rp. (-) 268.326.525 sedangkan 3R sebesar Rp. (+) 64.856.134. Sehingga pengelolaan jirigen hemodialisa secara reduce, reuse, recycle yang lebih menguntungkan daripada pengelolaan jirigen hemodialisa secara pengangkutan dan pemusnahan. Dengan alasan pengelolaan jirigen hemodialisa secara reduce, reuse, recycle dapat menurunkan biaya pengeluaran rumah sakit serta menciptakan budaya ramah lingkungan.

Kata Kunci : Pengelolaan, Jirigen Hemodialisa, Cost Benefit Analysis
Analisis Pengaruh Pemahaman Akreditasi dan Karakteristik Individu terhadap Kinerja Karyawan Medis dan Non Medis di RSUD Kabupaten Karanganyar
Authors: Kusumawardhani Oktavy Budi , Rejeki Mirah , Octaviana Antasya , Nurcahyaningsih Intan , Ramadhani Riszi
Published: August 2024

Latar Belakang: Akreditasi menunjukkan komitmen nyata sebuah rumah sakit untuk meningkatkan keselamatan dan kualitas asuhan pasien, memastikan bahwa lingkungan pelayanannya aman dan rumah sakit senantiasa berupaya mengurangi risiko bagi para pasien dan staf rumah sakit. Tujuan: untuk mengetahui pengaruh pemahaman akreditasi dan karakteristik individu terhadap kinerja karyawan medis dan non medis di RSUD Kabupaten Karanganyar. Metode: Penelitian ini menggunakan jenis penelitian survey dengan pendekatan cross-sectional. Populasi yang digunakan pada penelitian ini yaitu karyawan medis yang berkarya di RSUD Kabupaten Karanganyar dengan jumlah responden sebanyak 100 responden. Teknik pengambilan sampling pada penelitian ini dengan metode simple random sampling. Untuk menguji hipotesis digunakan analisis regresi berganda. Kontribusi Penelitian: Penelitian ini dapat mengetahui pengaruh pemahaman akreditasi dan karakteristik individu terhadap kinerja karyawan medis dan non medis di RSUD Kabupaten Karanganyar. Hasil: Hasil dari penelitian ini yaitu terdapat pengaruh pemahaman akreditasi dan karakteristik individu terhadap kinerja karyawan medis sebesar 0,031 kurang dari 0,05 pada nilai signifikan dan tabel F yaitu 2.730 lebih dari F tabel 2.20 dan tidak ada pengaruh pada pemahaman akreditasi dan karakteristik individu terhadap kinerja karyawan non medis dengan nilai Sig 0,471 lebih dari nilai kepercayaan 0,05 dan tabel F 0.929 yang kurang dari F tabel 2,20. Kesimpulan: Pada kinerja karyawan medis yang berpengaruh yaitu pemahaman akreditasi sedangkan untuk karakteristik individu tidak terdapat pengaruh ke kinerja karyawan. Sedangkan untuk kinerja karywan non medis baik pemahaman akreditasi atau karakteristik individu tidak terdapat pengaruh.
Kata Kunci: Pemahaman Akreditas, Karakteristik Individu, Kinerja Karyawan Medis, Kinerja Karyawan Non Medis,
Burnout Pada Perawat di Ruang Rawat Inap di Rumah Sakit: Studi Deskriptif
Authors: Fatimah Fatma Siti , Yugistyowati Anafrin
Published: August 2024

Perawat yang bekerja di rawat inap mempunyai tantangan serta tanggungjawab yang berkelanjutan sehingga dapat menyebabkan stres selama bekerja menyebabkan kelelahan secara emosional dan fisik atau burnout. Penelitian ini bertujuan untuk mengetahui gambaran burnout pada perawat di rawat inap.  Desain penelitian ini deskriptif analitik dengan pendekatan cross sectional. Penelitian dilakukan di Teknik sampel yang digunakan yaitu nonprobability sampling dengan jenis total sampling. Sampel dalam penelitian ini berjumlah 85 responden. Penelitian dilaksanakan di Rumah Sakit Dr. Soetarto Yogyakarta. Penelitian dilaksanakan pada bulan Juni tahun 2022. Alat ukur instrument yang digunakan yaitu kuesioner burnout. Uji statistik yang digunakan adalah univariat. Hasil penelitian menunjukkan Penelitian ini dapat disimpulkan burnout perawat di ruang rawat inap mayoritas dalam kategori sedang yaitu sebesar 57 (67.1%) perawat. Sehingga hal ini perlu perhatian khusus dari manajemen Rumah Sakit untuk mengatasi burnout sehingga kinerja perawat menjadi optimal.

 

Kata Kunci: Burnout; Kelelahan kerja; Perawat
Ethical Considerations in Infodemic Management: Systematic Scoping Review (Preprint)
Authors: Germani Federico , Spitale Giovanni , Machiri Sandra Varaidzo , Ho Calvin Wai Loon , Ballalai Isabella , Biller-Andorno Nikola , Reis Andreas Alois
Published: August 2024

BACKGROUND

During health emergencies, effective infodemic management has become a paramount challenge. A new era marked by a rapidly changing information ecosystem, combined with the widespread dissemination of misinformation and disinformation, has magnified the complexity of the issue. For infodemic management measures to be effective, acceptable, and trustworthy, a robust framework of ethical considerations is needed.

OBJECTIVE

This systematic scoping review aims to identify and analyze ethical considerations and procedural principles relevant to infodemic management, ultimately enhancing the effectiveness of these practices and increasing trust in stakeholders performing infodemic management practices with the goal of safeguarding public health.

METHODS

The review involved a comprehensive examination of the literature related to ethical considerations in infodemic management from 2002 to 2022, drawing from publications in PubMed, Scopus, and Web of Science. Policy documents and relevant material were included in the search strategy. Papers were screened against inclusion and exclusion criteria, and core thematic areas were systematically identified and categorized following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We analyzed the literature to identify substantive ethical principles that were crucial for guiding actions in the realms of infodemic management and social listening, as well as related procedural ethical principles. In this review, we consider ethical principles that are extensively deliberated upon in the literature, such as equity, justice, or respect for autonomy. However, we acknowledge the existence and relevance of procedural practices, which we also consider as ethical principles or practices that, when implemented, enhance the efficacy of infodemic management while ensuring the respect of substantive ethical principles.

RESULTS

Drawing from 103 publications, the review yielded several key findings related to ethical principles, approaches, and guidelines for practice in the context of infodemic management. Community engagement, empowerment through education, and inclusivity emerged as procedural principles and practices that enhance the quality and effectiveness of communication and social listening efforts, fostering trust, a key emerging theme and crucial ethical principle. The review also emphasized the significance of transparency, privacy, and cybersecurity in data collection.

CONCLUSIONS

This review underscores the pivotal role of ethics in bolstering the efficacy of infodemic management. From the analyzed body of literature, it becomes evident that ethical considerations serve as essential instruments for cultivating trust and credibility while also facilitating the medium-term and long-term viability of infodemic management approaches.
Mobile Apps and Wearables for Cardiovascular Health: Review and Analysis (Preprint)
Authors: Chauhan Gauri Kumari , Vavken Patrick , Jacob Christine
Published: August 2024

BACKGROUND

Cardiovascular diseases continue to be the leading cause of global morbidity and mortality. In response, an increasing number of individuals are adopting mobile health apps and wearable devices. These technologies provide critical insights into heart health and fitness, enabling users to actively monitor their well-being and manage their medications.

OBJECTIVE

This review aimed to investigate the current landscape of mHealth apps and wearables designed for cardiovascular health, with a specific focus on the DACH region (Germany, Austria, and Switzerland). It evaluated their benefits for both patients and clinicians, while also analyzing how well these technologies integrate into the broader healthcare ecosystem.

METHODS

To identify heart health apps, a keyword search was performed on both the Swiss Apple App and Google Play Stores, while a separate search on Google targeting heart health wearables. The identified apps and wearables were evaluated using the foundational and contextual criteria of the sociotechnical framework for assessing patient-facing eHealth tools.

RESULTS

After filtering out apps and wearables that did not meet specific criteria, the review analyzed 20 apps and 22 wearables. While all the apps were available in the DACH region, only 30% were specifically designed for these countries. Only 25% of the apps included gender-specific information, and 40% were based on evidence-based research. However, 25% provided no research or general information on cardiovascular health. Four apps had clinical integration, but only 10% effectively enhanced clinician workflows. Privacy policies were present in 95% of the apps, with 75% adhering to GDPR regulations; one app had no data protection policy. Medically certified apps were limited to 20%. For wearables, only 9% were tailored to the DACH region, and 40% addressed women’s health. While around 60% offered clinical integration, only 9% improved clinical workflows. Twelve percent of wearables were medically certified, and 77% referenced scientific or peer-reviewed research. All wearables included a privacy policy.

CONCLUSIONS

The review highlighted a broad range of mHealth tools available to users, yet only a few provided significant value to both patients and clinicians while effectively integrating into the healthcare system. Many of these tools inadequately addressed the needs of women, who are disproportionately affected by cardiovascular diseases, as their specific needs were often overlooked. Moreover, the benefits for clinicians were sometimes insufficient. These findings emphasize the need for mHealth tools that are evidence-based and tailored to the needs of both patients and healthcare providers, aiming to bridge the gap between them and enhance care management.

CLINICALTRIAL

NA
Study on the Impact of Combined Exercise and Various Dietary Approaches Based on Digital Technology on the Body Composition of Obese College Students (Preprint)
Authors: ChengYuan Hu , Zixin Lv , Jieping Zhu , Chunyuan Lai , Dongjuan Guo , Maolin Chen , Xiaoyan Cheng , mingxin Rao , Xinyou Zhou , Liqiang Su
Published: August 2024

BACKGROUND

Obesity has become a global health crisis, with projections indicating that by 2030, the number of overweight or obese individuals in China will surge to 790 million. Lifestyle interventions are a crucial component of weight loss programs, yet digital, personalized, and theory- and evidence-based lifestyle interventions remain limited.

OBJECTIVE

To investigate the impact of a combination of various dietary approaches and exercise, based on digital technology, on the body composition of obese college students.

METHODS

A total of 129 college students (age: 18.3 ± 0.7 years, weight: 89.9 ± 13.6 kg, BMI: 30.6 ± 3.3 kg/m²) were recruited from Jiangxi Normal University. An 8-week weight loss intervention was conducted on obese college students using a combination of exercise and various dietary approaches based on digital intervention. The exercise regimen included two days per week of one-hour resistance training and at least five times per week of sunlight running, with each run not less than 2 km. The dietary interventions consisted of a low-calorie diet (LCD), a twice-per week fasting diet (TWF), and a 16/8 time-restricted feeding diet (TRF). Changes in body composition indicators (muscle mass, fat mass, and water content) were assessed before and after the intervention. Participants were divided into three groups (LCD, TWF, TRF) for the experiment.

RESULTS

The 8-week intervention led to improvements in the body composition of obese college students. Additionally, it was found that compared to baseline, the male participants in the TWF group experienced a significant reduction in fat indices, and the female participants in the LCD group also showed a significant decrease in fat indices after the 8-week intervention.

CONCLUSIONS

In the process of weight loss through the combination of exercise and dieting, using digital technology methods, various dietary approaches combined with exercise have distinct effects on body composition. Among the muscle indices, the TRF group experienced a rapid decrease in lean body mass at four weeks, which remained stable at eight weeks, with a slight increase observed in females. Regarding fat indices, males in the TWF group achieved better fat reduction, while females in the LCD group had a more significant decrease in fat mass. In terms of water content, both males and females in the TWF group maintained better hydration levels.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR2300073166
Health Information Avoidance Behavior and Influencing Factors of Cancer Patients in the Smart Media Era: A Preliminary Exploratory Study (Preprint)
Authors: Wang Fuzhi
Published: August 2024

BACKGROUND

Objectives: To explore the influencing factors and path of health information avoidance behavior of cancer patients in the age of smart media, and to construct a theoretical model of influencing factors. Methods: Face-to-face interviews were used to collect primary data, following the steps of the rooted theory research method. NVivo 12 software was applied to code and analyze the data, and a theoretical model of the factors influencing the health information avoidance behaviors of cancer patients was constructed by combining with the Stimulus-Human Body-Response (SOR) theory. Results: This study proposed six research hypotheses by analyzing the content of the interviews, which showed a causal relationship between psychological factors and health information avoidance behavior; personal, informational, and environmental factors, while indirectly influencing the health information avoidance behavior of cancer patients through the mediating role of psychological factors; capacity factors moderated the chain of factors from information factors and environmental factors to psychological factors to health information avoidance behaviors, respectively. Conclusions: In this study, we proposed a theoretical model of the factors influencing cancer patients' health information avoidance behavior in the smart media era. This model can summarize the influencing factors of cancer patients' occurrence of health information avoidance behaviors in the environment of the Smart Media Era, and provides research hypotheses and theoretical frameworks for further explaining the role path relationships between the influencing factors.
The effect of multiple trauma with rhabdomyolysis-induced acute kidney injury on the functional state of main body systems
Authors: Dubyna V.M. , Kravets O.V.
Published: August 2024

Background. Traumatic injuries often lead to rhabdomyolysis, the destruction of muscle tissue, which causes leakage of the intracellular contents of myocytes into the bloodstream. The most common systemic complication of rhabdomyolysis is acute kidney injury (AKI). It occurs with a frequency of 10 to 55 % and is associated with a poor prognosis, especially with multiple organ failure. The aim of our work was to investigate the impact of multiple trauma complicated by rhabdomyolysis and AKI on the state of the body’s main systems. Materials and methods. We examined 96 victims with multiple trauma complicated by rhabdomyolysis and AKI. Upon admission, we examined the frequency of vasopressor support, rate of diuresis, indicators of the blood count, biochemistry (hepatic, renal complex, electrolytes, creatine kinase, myoglobin), coagulogram, acid-base and gas composition of blood. Results. Severe multiple trauma caused a massive rhabdomyolysis with an increase in creatine kinase to 7058.3 ± 2726.2 units/l, myoglobin to 1433.1 ± 121.9 μg/l. The mean empirical blood loss volume was 2762.5 ± 363.4 mL, leading to posthemorrhagic anemia and thrombocytopenia. 56.3 % of victims needed vasopressor support. Stress hyperglycemia up to 9.2 ± 1.7 mmol/l was observed. Liver dysfunction manifested by a decrease in total protein to 45.3 ± 2.3 g/l, albumin to 26.9 ± 1.5 g/l, which created a risk of interstitial edema. A significant cytolytic syndrome was formed with an increase in alanine aminotransferase to 466.5 ± 141.4 U/l, aspartate aminotransferase to 822.9 ± 187.9 U/l. Moderate hypocoagulation was observed with a decrease in the prothrombin index to 74.6 ± 4.3 % and an increase in the international normalized ratio to 1.4 ± 0.1; activated partial thromboplastin time and fibrinogen level remained within normal limits. The inflammatory reaction manifested by leukocytosis up to (15.3 ± 1.3) × 109/l. AKI was accompanied by an increase in creatinine to 402.1 ± ± 58.6 μmol/l, urea to 19.9 ± 3.0 mmol/l. Diuresis on the first day after admission averaged 0.47 ± 0.08 ml/kg/h. Hyperkalemia was observed in 47.2 % of victims: in 26.5 % of cases, potassium level was from 5.5 to 6.5 mmol/l, in 13.2 %, from 6.5 to 7.5 mmol/l, in 7.5 %, more than 7.5 mmol/l. These disorders were accompanied by subcompensated mixed acidosis. Conclusions. Multiple trauma complicated by rhabdomyolysis and acute kidney injury forms multiple organ failure with a high frequency of vasopressors need, post-hemorrhagic anemia, stress hyperglycemia, impairment of protein synthetic, pigment, enzymatic functions of the liver, coagulopathy, inflammatory syndrome, mixed acidosis and kidney damage per se, which manifested by oliguria, hyperazotemia and hyperkalemia.
GAMBARAN TINGKAT KEPUASAN IBU HAMIL SEBAGAI PENGGUNA APLIKASI ANCY-CARE DI KOTA YOGYAKARTA
Authors: Sari Okky Nurlita
Published: August 2024

ANCY-Care application (Anemia in Pregnancy-Care), a media that can be used by users  find information about anemia of pregnancy can be accessed with Android-based telephone. In knowing extent to which information systems or media be said succeed, End-User Computing Satisfaction (EUCS) is a method for measuring level of satisfaction of users an application system. The type of research used is descriptive method research with cross-sectional design. The sample in this study were 41 pregnant women who used the ANCY-Care application March-May 2019 in Yogyakarta City. This study used the End-User Computing Satisfaction (EUCS) model instrument that had been translated into Indonesian which had validity and reliability. This research has obtained the ethical feasibility of the research from the Ethics Committee Nursing Faculty of Medicine, Public Health, and Nursing Gadjah Mada University (KE/FK/1365/EC/2018). The overall level of user satisfaction is at an average value of 3.18 while the average value for each EUCS dimension is content dimension 3.12; accuracy dimensions 3.16; format dimensions 3.24; ease of use dimensions 3.20 and timeliness dimension 3.16. Users in generally satisfied in the use of the ANCY-Care application, while for user satisfaction each dimension is at the satisfied level.