bluuebunny/crossref_metadata_2025 huggingface dataset:
Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact
Authors: Zhang Xian , Noah J. Adam , Singh Rahul , McPartland James C. , Hirsch Joy
Published: February 2024

Social difficulties during interactions with others are central to autism spectrum disorder (ASD). Understanding the links between these social difficulties and their underlying neural processes is a primary aim focused on improved diagnosis and treatment. In keeping with this goal, we have developed a multivariate classification method based on neural data acquired by functional near infrared spectroscopy, fNIRS, during live eye-to-eye contact with adults who were either typically developed (TD) or individuals with ASD. The ASD diagnosis was based on the gold-standard Autism Diagnostic Observation Schedule (ADOS) which also provides an index of symptom severity. Using a nested cross-validation method, a support vector machine (SVM) was trained to discriminate between ASD and TD groups based on the neural responses during eye-to-eye contact. ADOS scores were not applied in the classification training. To test the hypothesis that SVM identifies neural activity patterns related to one of the neural mechanisms underlying the behavioral symptoms of ASD, we determined the correlation coefficient between the SVM scores and the individual ADOS scores. Consistent with the hypothesis, the correlation between observed and predicted ADOS scores was 0.72 (p < 0.002). Findings suggest that multivariate classification methods combined with the live interaction paradigm of eye-to-eye contact provide a promising approach to link neural processes and social difficulties in individuals with ASD.
FastEval Parkinsonism: an instant deep learning–assisted video-based online system for Parkinsonian motor symptom evaluation
Authors: Yang Yu-Yuan , Ho Ming-Yang , Tai Chung-Hwei , Wu Ruey-Meei , Kuo Ming-Che , Tseng Yufeng Jane
Published: February 2024

The Motor Disorder Society’s Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) is designed to assess bradykinesia, the cardinal symptoms of Parkinson’s disease (PD). However, it cannot capture the all-day variability of bradykinesia outside the clinical environment. Here, we introduce FastEval Parkinsonism (https://fastevalp.cmdm.tw/), a deep learning-driven video-based system, providing users to capture keypoints, estimate the severity, and summarize in a report. Leveraging 840 finger-tapping videos from 186 individuals (103 patients with Parkinson’s disease (PD), 24 participants with atypical parkinsonism (APD), 12 elderly with mild parkinsonism signs (MPS), and 47 healthy controls (HCs)), we employ a dilated convolution neural network with two data augmentation techniques. Our model achieves acceptable accuracies (AAC) of 88.0% and 81.5%. The frequency-intensity (FI) value of thumb-index finger distance was indicated as a pivotal hand parameter to quantify the performance. Our model also shows the usability for multi-angle videos, tested in an external database enrolling over 300 PD patients.
3,4-Dichlorophenylacetic acid acts as an auxin analog and induces beneficial effects in various crops
Authors: Tan Chao , Li Suxin , Song Jia , Zheng Xianfu , Zheng Hao , Xu Weichang , Wan Cui , Zhang Tan , Bian Qiang , Men Shuzhen
Published: February 2024

Auxins and their analogs are widely used to promote root growth, flower and fruit development, and yield in crops. The action characteristics and application scope of various auxins are different. To overcome the limitations of existing auxins, expand the scope of applications, and reduce side effects, it is necessary to screen new auxin analogs. Here, we identified 3,4-dichlorophenylacetic acid (Dcaa) as having auxin-like activity and acting through the auxin signaling pathway in plants. At the physiological level, Dcaa promotes the elongation of oat coleoptile segments, the generation of adventitious roots, and the growth of crop roots. At the molecular level, Dcaa induces the expression of auxin-responsive genes and acts through auxin receptors. Molecular docking results showed that Dcaa can bind to auxin receptors, among which TIR1 has the highest binding activity. Application of Dcaa at the root tip of the DR5:GUS auxin-responsive reporter induces GUS expression in the root hair zone, which requires the PIN2 auxin efflux carrier. Dcaa also inhibits the endocytosis of PIN proteins like other auxins. These results provide a basis for the application of Dcaa in agricultural practices.
Health–environment efficiency of diets shows nonlinear trends over 1990–2011
Authors: He Pan , Liu Zhu , Baiocchi Giovanni , Guan Dabo , Bai Yan , Hubacek Klaus
Published: February 2024

Understanding the impacts of diets on health and the environment, as well as their association with socio-economic development, is key to operationalize and monitor food systems shifts. Here we propose a health–environment efficiency indicator defined as a ratio of health benefits and four key food-related environmental impacts (greenhouse gas emissions, scarcity-weighted water withdrawal, acidifying and eutrophying emissions) to assess how diets have performed in supporting healthy lives in relation to environmental pollution and resource consumption across 195 countries from 1990 to 2011. We find that the health–environment efficiency of each environmental input follows a nonlinear path along the Socio-Demographic Index gradient representing different development levels. Health–environment efficiency first increases thanks to the elimination of child and maternal malnutrition through greater food supply, then decreases driven by additional environmental impacts from a shift to animal products, and finally shows a slow growth in some developed countries again as they shift towards healthier diets.
A model for N-to-C direction in prebiotic peptide synthesis
Authors: Zhang Li , Zhang Min , Guo Xiaofan , Gan Dingwei , Ye Yong , Zhao Yufen , Ying Jianxi
Published: February 2024

Prebiotic peptide synthesis achieves directional extension from N to C by starting with Ac-AA-NH2 as the N-terminal substrate and using AA-NH2 as the building block of the C-terminal extension.
Activation of non-polar bonds by an electron-rich gallagermylene
Authors: Bücker Anna , Gehlhaar Alexander , Wölper Christoph , Schulz Stephan
Published: February 2024

The electron-rich acyclic germylene LGa(μ–Cl)GeArMes (1) activates unpolar bonds as is shown in oxidative addition reactions with H2 and P4, yielding L(Cl)GaGe(H)2ArMes (2) and L(Cl)Ga(P4)GeArMes (3).
Investigation of dynamical flexibility of D5SIC-DNAM inside DNA duplex in aqueous solution: a systematic classical MD approach
Authors: Debnath Tanay , Cisneros G. Andrés
Published: February 2024

Dynamical conformational change of DS–DN incorporated DNA forming both WCF and nWCF conformers with SYN and ANTI orientations.
Hetero-bimetallic paddlewheel complexes for enhanced CO2 reduction selectivity in MOFs: a first principles study
Authors: McCarver Gavin A. , Yildirim Taner , Zhou Wei
Published: February 2024

DFT calculations show that doping Cu-based paddlewheel MOFs leads to more selective CO2 reduction products.
CO2 to dimethyl ether (DME): structural and functional insights of hybrid catalysts
Authors: Ghosh Anindya , Nag Debjani , Chatterjee Rupak , Singha Aniruddha , Dash Pratik Swarup , Choudhury Biswajit , Bhaumik Asim
Published: February 2024

Designing robust hybrid/bifunctional catalysts for CO2 to DME is of increasing importance in energy and environmental science to simultaneously address two important global challenges: carbon emission reduction and alternative fuel development.
Different sulfidized procedures and sulfur precursors alter the bacterial toxicity of sulfidized nanoscale zero-valent iron by affecting the physicochemical properties
Authors: Zhang Haoxuan , Li Long , Dong Haoran , Xiao Shuangjie , Deng Junmin , Huang Daofen , Xiao Junyang
Published: February 2024

Different sulfidized procedures and sulfur precursors influenced the bacterial toxicity of S-NZVI and the mechanisms.
A review of the world's salt reduction policies and strategies – preparing for the upcoming year 2025
Authors: Nie Ting , Huang Siqi , Yang Yuxin , Hu Anna , Wang Jianing , Cheng Zeneng , Liu Wenjie
Published: February 2024

Salt reduction initiatives, intertwined with national health, requires long-term and collaborative efforts among governments, food enterprises, public health experts, and the public. It is imperative to explore more effective methods for salt reduction to attain the global goal.
Semiconductor biohybrids for enhanced bifunctional wastewater sulfur and heavy metal removal
Authors: Zhang Yanju , Fang Furui , Qian Xiaoxiao , Li Liangchen , Huo Zongli , Zhang Jingjing , Dong Dandan , Huang Chaofeng , Li JiaYuan , Hu Yonghong , Mi Li
Published: February 2024

The proposed mechanism of the light-driven microbial desulphurization by the CdS–H. neapolitanus biohybrid system.
Determination of propellant products by time resolved and spatial distribution LIPS combined with high-speed schlieren imaging
Authors: Zhang Xinyu , Li An , Zhang Ying , Yin Yunsong , Wang Xianshuang , He Yage , Lyv Jing , Shan Yuheng , Liu Xiaodong , Yi Wen , Zhong Lin , Ren Yeping , Xia Min , Liu Ruibin
Published: February 2024

The characteristics of time resolution and spatial distribution of propellant products from laser induced micro-detonation are obtained by time correlated laser induced plasma spectroscopy (LIPS) combined with high-speed schlieren imaging.
An economical in-class sticker microfluidic activity develops student expertise in microscale physics and device manufacturing
Authors: Delgado Priscilla , Luna C. Alessandra , Dissanayaka Anjana , Oshinowo Oluwamayokun , Waggoner Jesse J. , Schley Sara , Fernandez Todd , Myers David R.
Published: February 2024

This activity enables students to construct geometrically complex microfluidics at their desk with no specialized equipment. It can be easily transported, and helped students significantly improve their understanding of miniaturization science.
Discovery of a new pyrido[2,3-d]pyridazine-2,8-dione derivative as a potential anti-inflammatory agent through COX-1/COX-2 dual inhibition
Authors: Rosa Fernanda A. , Gonçalves Davana S. , Pianoski Karlos E. , da Silva Michael J. V. , Ames Franciele Q. , Aguiar Rafael P. , Volpato Hélito , Lazarin-Bidóia Danielle , Nakamura Celso V. , Bersani-Amado Ciomar A.
Published: February 2024

The new pyrido[2,3-d]pyridazine-2,8-dione 7c showed potential anti-inflammatory activity as a COX-1/COX-2 dual inhibitor.
Single-atom cobalt encapsulated in carbon nanotubes as an effective catalyst for enhancing sulfur conversion in lithium–sulfur batteries
Authors: Samawi Khalida Abaid , Salman Ekhlas Abd-Alkuder , Hasan Hiba Ali , Mahmoud HassabAlla M. A. , Mohealdeen Sura Mohammad , Abdulkareem-Alsultan G. , Abdulmalek Emilia , Nassar Maadh Fawzi
Published: February 2024

Highly curved CNTs with CoN4 catalysts were synthesized as sulphur hosts, offering promising cathode material for Li–S batteries. They effectively mitigate the shuttle effect, improving battery performance.
An oriented MXene/silk fibroin nanofiber hydrogel with high strength and strain response ability
Authors: Li Nana , Yang Yuncong , Murugesan Balaji , Zhang Yong , Chen Zhuo , Yang Xiaogang , Cai Yurong
Published: February 2024

An oriented MXene/silk fibroin nanofiber hydrogel with excellence mechanical properties for highly sensitive flexible sensors.
Bio-inspired, sensitivity-enhanced, bi-directional airflow sensor for turbulence detection
Authors: Liu Fu , Zhao Yufeng , Xie Nan , Wang Yueqiao , Liu Meihe , Han Zhiwu , Hou Tao
Published: February 2024

We designed a bionic, sensitivity-enhanced, bi-directional airflow sensor by incorporating bio-inspired circular tip slits and enlarging the central part of the cruciform beam.
Machine learning in electron beam lithography to boost photoresist formulation design for high-resolution patterning
Authors: Zhao Rongbo , Wang Xiaolin , Xu Hong , Wei Yayi , He Xiangming
Published: February 2024

A high-precision photoresist imaging model and formulation optimizer for electron beam lithography are developed. The optimized photoresist formulation meets the preset imaging performance requirement, boosting photoresist material design.
Photoinduced electron transfer endows fluorogenicity in tetrazine-based near-infrared labels
Authors: Shen Tianruo , Li Xin , Liu Xiaogang
Published: February 2024

We rationalized the predominance of photoinduced electron transfer in quenching the fluorescence of tetrazine-based near-infrared fluorogenic labels.
HPLC-FLD determination of aflatoxins M1 and M2 in raw cow milk samples using in-syringe gas-controlled density tunable solidification of a floating organic droplet-based dispersive liquid–liquid microextraction method
Authors: Rabie Maede , Movassaghghazani Mohammadhosein , Afshar Mogaddam Mohammad Reza
Published: February 2024

An in-syringe gas-controlled density tunable solidification of a floating organic droplet-based dispersive liquid–liquid microextraction method was employed for the extraction of aflatoxins from cow milk samples prior to their quantification with HPLC equipped with a fluorescence detector.
Sustainable production of catechol derivatives from waste tung nutshell C/G-type lignin via heterogeneous Cu–NC catalytic oxidation
Authors: Zhu Guozhi , Xie Hongmei , Ye Dawei , Zhang Junjie , Huang Kangping , Liao Bing , Chen Jiazhi
Published: February 2024

A heterogeneous oxidative process is reported towards sustainable production of valuable catechol derivatives from the depolymerization of Tung nutshell C/G lignin by Cu–NC catalytic process. The CuO and Cu2O might be active species for oxidation.
A phenothiazine-functionalized pyridine-based AIEE-active molecule: a versatile molecular probe for highly sensitive detection of hypochlorite and picric acid
Authors: Vinayagam Dhandapani , Subramanian Karpagam
Published: February 2024

(1) The compound (PTH-AB-PY) demonstrated exceptional selectivity towards ClO− and picric acid with remarkable fluorescence properties. (2) The AIEE active molecule enhanced fluorescence emission and 90% aggregated compound was captured on a scanning electron microscopy.
Environmentally sustainable synthesis of whey-based carbon dots for ferric ion detection in human serum and water samples: evaluating the greenness of the method
Authors: Kayani Kawan F. , Shatery Omer B. A. , Mustafa Muhammad S. , Alshatteri Azad H. , Mohammed Sewara J. , Aziz Shujahadeen B.
Published: February 2024

Carbon dots (CDs) are valued for their biocompatibility, easy fabrication, and distinct optical characteristics.
Delocalisation enables efficient charge generation in organic photovoltaics, even with little to no energetic offset
Authors: Balzer Daniel , Kassal Ivan
Published: February 2024

Simulations reveal that both charge and exciton delocalisation can significantly improve the efficiency of charge generation in organic photovoltaics and explain the failure of classical hopping approaches.
Deciphering the liquid–liquid phase separation induced modulation in the structure, dynamics, and enzymatic activity of an ordered protein β-lactoglobulin
Authors: Rai Saurabh , Pramanik Srikrishna , Mukherjee Saptarshi
Published: February 2024

Liquid–liquid phase separation (LLPS) exhibited by an ordered protein β-lactoglobulin (β-LG) under crowded environment prompts alterations in conformational distribution leading to emergence of new promiscuous (esterase-like) activity.
Effect of surface modification on the distribution of magnetic nanorings in hepatocellular carcinoma and immune cells
Authors: Jiao Wangbo , Wen Nana , Wang Siyao , Zhou Guxiang , Lu Qiaoyi , Su Zijun , Wang Xinxin , Hu Shuwei , Xie Youbang , Zhang Nan , Liu Xiaoli
Published: February 2024

The distributions of ferrimagnetic vortex-domain iron oxide nanorings (FVIOs) with or without HCC-targeting peptide SP94 in different cells of HCC tumor microenvironment was studied in mouse models.
17O solid-state NMR study on exposed facets of ZnO nanorods with different aspect ratios
Authors: Song Benteng , Li Yuhong , Sun Yunhua , Peng Luming , Xie Ling-Hai
Published: February 2024

Based on the morphology and experimental spectra of ZnO nanorods, the 17O solid-state NMR signal at −18.8 ppm is proved to arise from both (101̄0) and (0002) exposed facets.
Enhanced photocatalytic performance of thiophene-modified graphitic carbon nitrides as donor–acceptor conjugated organic polymers
Authors: Liu Yanan , Lu Shuaishuai , Yuan Tong , Wang Siyuan , Bahnemann Janina , Jiang Fang , Chen Huan
Published: February 2024

The g-C3N4/TA was prepared by copolymerization calcination for photocatalytic BPA treatment. S doping and D–A structure synergistically promote electron transfer and ˙O2− generation.
Correction: Novel electrode material based on coral-like cerium orthoferrite (CeFeO3) for efficient alkaline water splitting
Authors: Seroglazova Anna S. , Lobinsky Artem A. , Nevedomskii Vladimir N. , Panchyk Vitaly V. , Semenov Valentin G. , Popkov Vadim I.
Published: February 2024

Correction for ‘Novel electrode material based on coral-like cerium orthoferrite (CeFeO3) for efficient alkaline water splitting’ by Anna S. Seroglazova et al., New J. Chem., 2023, 47, 20257–20261, https://doi.org/10.1039/D3NJ01898A.
Insights into the mechanism and origin of multifunctional ligand effects on chemoselectivity in Pd-catalyzed unnatural prenylation and geranylation of oxindoles with isoprene
Authors: Zhao Manzhu , Yuan Haiyan , Zhang Jingping
Published: February 2024

DFT calculations disclosed the mechanism and origin of multifunctional ligand effects on chemoselectivity in Pd-catalyzed unnatural prenylation and geranylation.
Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation
Authors: Aldworth Harry , Hooper Nigel M.
Published: February 2024

The amount of the low-density lipoprotein receptor (LDLR) on the surface of hepatocytes is the primary determinant of plasma low-density lipoprotein (LDL)-cholesterol level. Although the synthesis and cellular trafficking of the LDLR have been well-documented, there is growing evidence of additional post-translational mechanisms that regulate or fine tune the surface availability of the LDLR, thus modulating its ability to bind and internalise LDL-cholesterol. Proprotein convertase subtilisin/kexin type 9 and the asialoglycoprotein receptor 1 both independently interact with the LDLR and direct it towards the lysosome for degradation. While ubiquitination by the E3 ligase inducible degrader of the LDLR also targets the receptor for lysosomal degradation, ubiquitination of the LDLR by a different E3 ligase, RNF130, redistributes the receptor away from the plasma membrane. The activity of the LDLR is also regulated by proteolysis. Proteolytic cleavage of the transmembrane region of the LDLR by γ-secretase destabilises the receptor, directing it to the lysosome for degradation. Shedding of the extracellular domain of the receptor by membrane-type 1 matrix metalloprotease and cleavage of the receptor in its LDL-binding domain by bone morphogenetic protein-1 reduces the ability of the LDLR to bind and internalise LDL-cholesterol at the cell surface. A better understanding of how the activity of the LDLR is regulated will not only unravel the complex biological mechanisms controlling LDL-cholesterol metabolism but also could help inform the development of alternative pharmacological intervention strategies for the treatment of hypercholesterolaemia.
Read the Feed: High-Emotion Simulation of Preterm Feeding to Enhance Graduate-Level Training
Authors: Pitts Laura L. , Squires Lindsey R.
Published: February 2024

Purpose:

Therapeutic bottle feeding is a critical skill for speech-language pathologists (SLPs) managing the increasing and medically complex neonatal intensive care unit (NICU) and early intervention caseloads. Thus, we explored the role of a high-emotion preterm simulator, known as “Paul,” to increase knowledge, skills, and confidence related to infant feeding management for speech-language pathology graduate students.

Method:

A randomized controlled study compared learning outcomes of 27 participants following either a 1-hr lecture or 1-hr training with a preterm simulator. Outcomes included knowledge demonstrated on written examination, accuracy in identifying stress cues during simulated feeding, and self-reported anxiety levels related to clinically assessing infant feeding.

Results:

No baseline group differences were found on written examination or during a simulated bottle feeding. Both groups improved in written examination scores and identification of stress cues (
p
 < .001). Gains in written examination scores did not significantly differ between groups; however, after training, the simulator group correctly identified more stress cues during a simulated bottle feeding (
p
 < .001), and the lecture group reported reduced anxiety related to clinically evaluating infant feeding compared to simulator-trained students (
p
 < .05).

Conclusions:

All students demonstrated gains in written knowledge and identification of stress cues; however, simulation-based training was superior in developing the feeders' ability to identify stress cues during a hands-on simulated bottle-feeding scenario. Lecture-based training may have inflated students' perceptions in their clinical skills as they were less accurate in identifying stress cues during a simulated feeding but reported significantly reduced anxiety for administering a clinical evaluation of infant feeding compared to simulation-trained students. Hands-on training using high-fidelity simulation may capitalize on experiential learning to better build clinical feeding skills for future SLPs who may serve in NICU and early intervention settings, while eliminating the risk of potential errors during learning that could affect fragile neonates.
Over-the-Counter Hearing Aids Challenge the Core Values of Traditional Audiology
Authors: Menon Katherine N. , Hoon-Starr Michelle , Shilton Katie , Hoover Eric C.
Published: February 2024

Purpose:

Regulatory changes in the United States introduced over-the-counter (OTC) hearing aids with the goal of increasing the accessibility and affordability of hearing health care. It is critical to understand the values inherent to hearing health care systems to evaluate their effectiveness in serving people with hearing difficulty. In this study, we evaluated the relative importance of values across service delivery models and the extent to which the introduction of OTC hearing aids represents a values shift relative to traditional audiology.

Method:

We performed a qualitative content analysis of two document categories: critique documents that motivated the creation of OTC hearing aids and regulatory documents that defined OTC hearing aids. Team members coded portions of text for the values they expressed. In total, 29,235 words were coded across 72 pages in four documents. Rank-order analyses were performed to determine the prioritization of values within each category of documents and subsequently compare values between OTC and traditional audiology documents analyzed in a previous study.

Results:

Critique and regulatory documents both prioritized values related to reducing barriers to hearing aid access and use, but the lack of a significant correlation in the rank order of values in these documents was evidence of inconsistency between the motivation and implementation of OTC hearing aids. Differences in the rank order of values in the OTC documents compared to traditional audiology were consistent with a values shift.

Conclusions:

The introduction of OTC as a solution to low hearing aid use represents a values shift, challenging the values of traditional audiology. This research demonstrates a need to establish the values of hearing health care service delivery through a consensus of stakeholders, including individuals from diverse backgrounds underserved by the traditional model.
Small Sample Fiber Full State Diagnosis Based on Fuzzy Clustering and Improved ResNet Network
Authors: Li Xiangqun , Liang Jiawen , Zhu Jinyu , Shi Shengping , Ding Fangyu , Sun Jianpeng , Liu Bo
Published: February 2024

The optical time domain reflectometer (OTDR) curve features of communication fibers exhibit subtle differences among their normal, subhealthy, and faulty operating states, making it challenging for existing machine learning‐based fault diagnosis algorithms to extract these minute features. In addition, the OTDR curve field fault data are scarce, and data‐driven deep neural network that needs a lot of data training cannot meet the requirements. In response to this issue, this paper proposes a communication fiber state diagnosis model based on fuzzy clustering and an improved ResNet. First, the pretrained residual network (ResNet) is modified by removing the classification layer and retaining the feature extraction layers. A global average pooling (GAP) layer is designed as a replacement for the fully connected layer. Second, fuzzy clustering, instead of the softmax classification layer, is employed in ResNet for its characteristic of requiring no subsequent data training. The improved model requires only a small amount of sample training to optimize the parameters of the GAP layer, thereby accommodating state diagnosis in scenarios with limited data availability. During the diagnosis process, the OTDR curves are input into the network, resulting in 512 features outputted in the GAP layer. These features are used to construct a feature vector matrix, and a dynamic clustering graph is formed using fuzzy clustering to realize the fiber state diagnosis. Through on‐site data detection and validation, it has been demonstrated that the improved ResNet can effectively identify the full cycle of fiber states.
Dimensional analysis: Not a recipe!
Authors: Salençon Jean
Published: February 2024

Dimensional analysis is commonly used to reduce the number of parameters and variables that shall be taken into account in the analysis of a physical problem, by means of the construction of a few non-dimensional products. It is derived from the simple principle that the very concept of a physical law implies that it shall be expressed by mathematical relationships between measures of the involved physical quantities, which must be invariant with respect to any change in the units chosen for measuring these quantities. This principle is expressed mathematically through Vaschy-Buckingham’s theorem, also known as the pi theorem. Inspired from Saint-Guilhem’s papers (Saint-Guilhem R. 1962. Les principes de l’analyse dimensionnelle, invariance des relations vectorielles dans certains groupes d’affinités. Mémorial des sciences mathématiques. Paris: Gauthier-Villars, Vol. 152 Saint-Guilhem R. 1971. Les principes généraux de la similitude physique. Gauthier-Villars: Eyrolles; Saint-Guilhem R. 1985. Sur les fondements de la similitude physique : le théorème de Federman. J Mec Th Appl 4 (3): 337–356; Debongnie JF. 2016. Sur le théorème de Vaschy-Buckingham. [http:// hdl.handle.net/2268/197814] and Barenblatt GI. 1987. Dimensional analysis. New York: Gordon & Breach Sc. Publ) the paper aims at proposing a fairly didactic presentation, where, as strongly advised by Barenblatt, basic concepts such as physical quantities, dimensions, consistent systems of units are first explained. Then, the constitution of dimensionless products is thoroughly developed before specifying the correct number of independent dimensionless products that can be obtained from a given number of physical quantities. Finally, the pi theorem is stated, with a proof in the spirit of Vaschy’s original one. Historical comments evoke Galileo’s analysis, refer to the many contributions by celebrated scholars in the 18th and 19th centuries and conclude with more recent mathematical approaches.
Conduction System Pacing: historische und aktuelle Entwicklungen der Schrittmachertherapie
Authors: Saghabalyan Davit , Baldenhofer Gerd , Diaz Ramirez Ivan
Published: February 2024

Die Schrittmachertherapie mittels Stimulation des spezifischen Reizleitungssystems (Conduction System Pacing) nimmt Fahrt auf. Die randomisierten Studien, die den tatsächlichen Nutzen dieser Methode beweisen sollen, sind schon unterwegs. Die bisherigen Daten weisen auf relevante Vorteile gegenüber konventionellen Methoden hin, jedoch bleiben die anfallenden Zusatzkosten, aufwendige Implantationstechnik und die im Vergleich zur rechtsventrikulären Stimulation niedrigere Erfolgsrate neben den noch fehlenden Empfehlungen der ESC-Schrittmacherleitlinie die entscheidenden Hindernisse für die breitere Verwendung des Conduction System Pacing in Deutschland. In Anbetracht des 2023 zu diesem Thema publizierten Konsensuspapiers der EHRA möchten wir nun die Erfahrungen der letzten Jahrzehnte im Bereich der Herzschrittmachertherapie und die aktuellen Entwicklungen zusammenfassen.
Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study
Authors: Hein Alexander , Fasching Peter A. , Hack Carolin C. , Maass Nicolai , Aktas Bahriye , Kümmel Sherko , Thomssen Christoph , Wolf Christopher , Kolberg Hans-Christian , Brucker Cosima , Janni Wolfgang , Dall Peter , Schneeweiss Andreas , Marme Frederik , Ruebner Matthias , Theuser Anna-Katharin , Hofmann Nadine M. , Böhm Sybille , Almstedt Katrin , Kellner Sara , Nabieva Naiba , Gass Paul , Sütterlin Marc W. , Lück Hans-Joachim , Schmatloch Sabine , Kalder Matthias , Uleer Christoph , Juhasz-Böss Ingolf , Hanf Volker , Jackisch Christian , Müller Volkmar , Rack Brigitte , Belleville Erik , Wallwiener Diethelm , Rody Achim , Rauh Claudia , Bayer Christian M. , Uhrig Sabrina , Goossens Chloë , Huebner Hanna , Brucker Sara Y. , Häberle Lothar , Fehm Tanja N.
Published: February 2024

Adjuvant treatment of patients with early-stage breast cancer (BC) should include an aromatase inhibitor (AI). Especially patients with a high recurrence risk might benefit from an upfront therapy with an AI for a minimum of five years. Nevertheless, not much is known about the patient selection for this population in clinical practice. Therefore, this study analyzed the prognosis and patient characteristics of postmenopausal patients selected for a five-year upfront letrozole therapy.

From 2009 to 2011, 3529 patients were enrolled into the adjuvant phase IV PreFace clinical trial (NCT01908556). Postmenopausal hormone receptor-positive BC patients, for whom an upfront five-year therapy with letrozole (2.5 mg/day) was indicated, were eligible. Disease-free survival (DFS), overall survival (OS) and safety in relation to patient and tumor characteristics were assessed.

3297 patients started letrozole therapy. The majority of patients (n = 1639, 57%) completed the five-year treatment. 34.5% of patients continued with endocrine therapy after the mandated five-year endocrine treatment. Five-year DFS rates were 89% (95% CI: 88–90%) and five-year OS rates were 95% (95% CI: 94–96%). In subgroup analyses, DFS rates were 83%, 84% and 78% for patients with node-positive disease, G3 tumor grading, and pT3 tumors respectively. The main adverse events (any grade) were pain and hot flushes (66.8% and 18.3% of patients).

The risk profile of postmenopausal BC patients selected for a five-year upfront letrozole therapy showed a moderate recurrence and death risk. However, in subgroups with unfavorable risk factors, prognosis warrants an improvement, which might be achieved with novel targeted therapies.
Successful Retrieval of Retained Rotablator Burr in the Mid Left Anterior Descending Coronary Artery using a Retrograde Approach: A Case Report
Authors: Inala Yoshitha , Robken Jon , Shammas Nicolas W.
Published: February 2024

We present a rare complication of Rotablator (Boston Scientific) atherectomy during percutaneous coronary intervention in a 67-year-old patient with a history of coronary artery disease and prior coronary artery bypass graft (CABG) surgery. The fracture of the Rotablator drive shaft and retention of the Rotablator burr in the mid left anterior descending coronary artery posed significant challenges in patient management. This case demonstrates the successful extraction of the retained Rotablator burr using retrograde total occlusion recanalization and highlights the importance of understanding the potential complications and management strategies in complex interventional cardiology procedures.
The physiology and anatomy study in leaves of Saragolla and Svevo wheat cultivars under polyethylene glycol-simulated drought stress
Authors: Licaj Ilva , Germinario Chiara , Di Meo Maria Chiara , Varricchio Ettore , Rocco Mariapina
Published: February 2024

Drought stress is increasing in frequency and severity with the progression of global climate change, thereby becoming a major concern for the growth and yield of crop plants, including wheat. The current challenge is to explore different ways of developing wheat genotypes with increased tolerance to drought. Therefore, we renewed interest in ‘ancient’ varieties expected to be more tolerant to environmental stress than the few elite varieties nowadays cultivated. This study aimed to perform comparative analysis of the effect of drought-simulating polyethylene glycol (PEG-6000) treatment on morpho-anatomical and physiological foliar traits of two durum wheat seedlings cultivars, Saragolla and Svevo, as these can reflect the adaptability of the plant to the environment to a certain extent. Results demonstrated that drought-stressed Saragolla leaves exhibited a greater reduction of stomatal density, a minor reduction of stomatal pore width, a wider xylem vessel mean area, greater compactness of mesophyll cells, a minor loss of chlorophyll content, as well as better photosynthetic and growth performance compared to the other variety. From such behaviours, we consider the Saragolla cultivar more drought tolerant than Svevo and therefore probably very promising for cultivation in dry areas.
What do parents think about child’s routine height and weight measures? A qualitative study
Authors: Krstic Slavica , Dennis Sarah , Southcombe Faye , Denney-Wilson Elizabeth
Published: February 2024

Background Routine height and weight screening of children accessing health services in South Western Sydney Local Health District (SWSLHD) was implemented to address childhood obesity. This qualitative study aims to explore the views of parents/carers regarding the role of healthcare professionals (HCPs) in measuring their child and raising the issue of weight when accessing health services. Methods A qualitative study using semi-structured interviews was performed. Parents/carers of children who had their height and weight measured at a SWSLHD facility were invited to participate. Purposive sampling was used to select parents/carers of children from different body mass index (BMI) categories and different health settings. Interviews were digitally audio-recorded and transcribed verbatim. The de-identified data were coded and analysed thematically using NVivo. Results A total of 24 semi-structured interviews were conducted. Of these, 14 were of parents/carers of children who were outside the healthy weight range. Three main themes were identified: parental perception of their child’s weight, parental expectations, and parental challenges. We found that many parents/carers were unaware of their child’s weight status and often underestimated it. Many were open to receiving advice and resources as long as it was addressed professionally and respectfully. Conclusions Contrary to the views of some health professionals, parents/carers want to know their child’s weight status. They valued the information and advice provided by well-trained clinicians who are confident to raise the issue of weight with parents/carers.
Exploring organisational readiness to implement a preventive intervention in Australian general practice for overweight and obese patients: key learnings from the HeLP-GP trial
Authors: Parker Sharon , Tran An , Saito Shoko , McNamara Carmel , Denney-Wilson Elizabeth , Nutbeam Don , Harris Mark Fort ,   on behalf of the Health e-Literacy for Prevention in General Practice (HeLP-GP) Trial Group
Published: February 2024

Background The HeLP-GP trial aimed to increase the capacity of practice nurses to deliver weight management to overweight and obese patients through an intervention comprising a health check, a lifestyle app and/or telephone coaching. This paper describes implementation through the lens of organisational readiness with emphasis on the role of the practice nurse. Methods Routinely collected mixed method research data including practice surveys, field notes, and diaries and process data were mapped against the domains: motivation to implement, general capacity and intervention-specific capacity. Results Organisational readiness varied considerably, particularly the domain of intervention-specific capacity. Practice nurse turnover negatively impacted the implementation, affecting half of the practices. We observed a general lack of practice-based support for intervention delivery, and varying levels of interest, skill and confidence in delivering the intervention. Nurses struggled to complete the research and intervention tasks in a timely way. Conducting risk assessments and referring to coaching were generally not problematic; however, we noted lower confidence levels with the lifestyle app and instructing patients to use it. Conclusions We found a lack of general ‘readiness’ inherent in the nursing role, particularly related to their capacity to complete intervention tasks and practice-level support to implement the intervention. For nurses in general practice to fulfil their potential in supporting patients to reduce risk and adopt healthier life choices, our study indicates that more could be done to improve their workforce positioning and remuneration, which may, in turn, improve continuity of care, retention and individual motivation.
Ten years of camera trapping for a cryptic and threatened arboreal mammal – a review of applications and limitations
Authors: Harley Dan , Eyre Arabella
Published: February 2024

For many cryptic mammal species, limited distributional data restrict the scope or effectiveness of conservation actions, particularly in relation to habitat protection and/or management. The critically endangered Leadbeater’s possum illustrates this, with wet forests throughout its range impacted by logging and bushfire. The possum’s habitat has been subject to major disturbance and degradation over recent decades; however, the cryptic behaviour of the species has meant population trajectories have been difficult to monitor. Since 2012, surveys for the possum have been greatly expanded, predominantly based around camera trapping. This paper examines outcomes following a decade of targeted camera trapping for this high-profile threatened species. There have been 1143 camera trapping detections of Leadbeater’s possum since 2012, representing 57% of all detections over this period. For comparison, there were just 274 detections of the species over a comparable period during the preceding decade using all other survey techniques. The substantial increase in records reflects greater survey effort, but also the effectiveness of baited camera traps at detecting this cryptic mammal. As a consequence, we have greatly improved understanding of the species’ distribution within its core range following major bushfire in 2009. These detection data have informed some aspects of forest management, including the establishment of small logging exclusion areas. Other applications of camera traps have included directing them at dens, providing a non-invasive means of monitoring translocated individuals and reproductive success. Several important caveats regarding camera trapping surveys are discussed, particularly that detection/non-detection data may be insensitive at detecting population declines for communally-denning species such as Leadbeater’s possum, where abundance may change more readily than occupancy. A risk accompanying the proliferation of camera trapping is over-reliance on rapid, one-off camera surveys that fail to provide the in-depth insights on demography and population dynamics required to inform effective management of threatened species. This case study highlights the importance of robust survey and monitoring data to inform species conservation planning and management. The results also demonstrate that camera trapping can be as effective and efficient in determining occupancy for some arboreal mammals as it is for terrestrial species, where it is more commonly applied.
Pronoun interpretation in Italian
Authors: White Lydia , Goad Heather , Garcia Guilherme Duarte , Guzzo Natália Brambatti , Smeets Liz , Su Jiajia
Published: February 2024

We explore potential effects of prosody on pronoun interpretation in Italian, building on previous research which
has shown that second language learners/users (L2ers) assign non-target interpretations to overt pronouns. We investigate effects
of contrastive stress and pause, proposing that these will result in changes to default antecedent preferences for overt and null
pronouns, for L2ers and for native speakers. An experiment was conducted, involving English-speaking L2ers of Italian and Italian
native speakers. Participants were presented with auditory stimuli like Lorenzo ha scritto a Roberto quando Ø/lui si è
trasferito a Torino ‘Lorenzo wrote to Roberto when (he) moved to Turin’ and indicated their preferred antecedent for
the pronoun. Overt versus null pronouns, presence versus absence of stress on overt pronouns, and presence versus absence of pause
between clauses were manipulated. The results yielded significant differences for antecedent choices between null and overt
pronouns, consistent with earlier literature. In addition, stress was significant for both groups. Implications of a prosodic
approach to ambiguity resolution are discussed.
Causativité et réactivité dans le fonctionnement du marqueur de discours Je me suis laissé
dire
Authors: Anscombre Jean-Claude
Published: February 2024

Cette étude se propose dans un premier temps de définir de façon opératoire la notion de marqueur de
discours, en la situant par rapport à la présence de cinq paramètres : la fonction de connexion, la
fonction d’attitude, la possibilité de mise en incise, l’intonation, et enfin
le degré de figement. Dans un second temps, on situera le marqueur je me suis laissé dire en
fonction de ces cinq paramètres, sous forme d’une interprétation en termes de structure profonde. Dans un
troisième temps enfin, une étude approfondie du fonctionnement et des propriétés linguistiques de ce marqueur en termes de
causativité et de réactivité, permettra de rendre compte de l’impossibilité de ce qui serait
en espagnol l’équivalence me dejé decir.
Dis voir et oye tú en contraste
Authors: Gómez-Jordana Ferary Sonia
Published: February 2024

Le but de notre article est d’étudier le marqueur en dire dis voir et son correspondant
espagnol oye tú. Nous nous pencherons ici sur les valeurs distributionnelles et sémantico-pragmatiques de
dis voir en français contemporain, afin de vérifier sa fonction dans le discours. Nous apporterons également
une analyse diachronique qui explique les traces de l’ancienne locution verbale. Contrairement à ce que l’on
pourrait penser, l’équivalent espagnol ne part pas d’un verbe de dire mais du verbe oír
‘entendre’ impliquant également l’interlocuteur par le biais de l’impératif et de la deuxième personne du
singulier – oye tú. Nous verrons comment, par un processus de pragmaticalisation, les marqueurs dis
voir et oye tú ne peuvent pas être considérés stricto sensu des marqueurs de dire
ni de perception.
Autour de il n’y a pas à dire et de incontestablement
Authors: Tejedor de Felipe Didier
Published: February 2024

Dans cet article, nous abordons l’analyse formelle et sémantico-pragmatique des opérateurs il n’y a pas à
dire et de incontestablement. Nous défendons qu’il n’y a pas à dire, P, permet de
présenter P comme une conclusion explicite prise en charge par le locuteur et en rapport direct avec son cotexte
gauche où elle occupe le statut de conclusion implicite. L’adverbe incontestablement implique une double prise en
charge de P, d’abord par la simple assertion de P et, ensuite par le rejet, de la part du
locuteur, du doute quant à la validité de P. Dans un cas comme dans l’autre, les opérateurs discursifs marquent
une prise en charge de P et contribuent à la construction d’un ethos positif du locuteur.
Demonstration of MHz piezoelectric micromachined ultrasonic transducers array and its potential application for biomedical treatment
Authors: Wang Dengke , Ji Yucheng , Wang Shaokun , Zhang Songsong
Published: February 2024

In this paper, we successfully developed the 24 × 31 piezoelectric micromachined ultrasound transducers (PMUTs) array with 8 inch complementary metal oxide semiconductor (CMOS) compatible processes. Scandium aluminum nitride (ScxAl1−xN) thin film (x = 20%) was used as the piezoelectric material. The PMUTs array was fabricated on 8 inch cavity silicon-on-insulator wafers with the device silicon layer thickness of only 3 μm and a cavity pitch of 59 μm. The wafer-level electrical test was conducted using inline auto-prober and the yield rate >90% was achieved across the 8 inch wafer. The following acoustic test on our PMUTs array (1.5 mm × 2.0 mm) indicated the transmit sensitivity of 18.4 kPa V−1 @ 10 mm @ 11.6 MHz in oil with −3 dB bandwidth of 2.3 MHz. In order to validate the potential of using PMUTs array for biomedical treatments, subsequent ultrasonic heating experiments were carried out on a silicone block. A temperature rise of 4 °C was achievable in about 50 s. These results demonstrate that the potential of using PMUTs array as a disposable biomedical device in many therapeutic applications, for example, a treatment for dry eye disease.
Bi-based bracelet-like monolayer with negative in-plane Poisson’s ratio and enhanced photocatalytic performance: a first-principles study
Authors: Kedidi N , Ayadi T , Debbichi M
Published: February 2024

Auxetic materials are in high demand for advanced applications due to their relatively rare negative Poisson’s ratio in two-dimensional materials. This study investigates the structural, mechanical, electronic, optical and photocatalytic properties of the AsBiTe3 monolayer(ML) using first-principles calculations. Through analysis of phonon dispersion curves, ab-initio molecular dynamics simulations, and Born conditions, we have confirmed the thermal, dynamic, and mechanical stability of the AsBiTe3 monolayer. The study of the mechanical properties of this material revealed significant anisotropy and a bidirectional in-plane negative Poisson’s ratio (NPR). In addition, electronic band structures calculated, with and without spin–orbit coupling (SOC) using the HSE functional, indicate that this monolayer exhibits the characteristics of an indirect-gap semiconductor around 1.17 and 1.32 eV, respectively. Notably, by assessing the optical properties of AsBiTe3 monolayer, it has been found that this monolayer has a strong light-harvesting capability with an absorption coefficient higher than 105 cm −1 in the visible region. Fascinatingly, under a biaxial 1

%

and 4

%

tensile and −2% compressive strain, the band edge of the AsBiTe3 monolayer extends across the redox potential of water at pH = 0, 7 and 14, respectively. This suggests that this monolayer holds promise as a potential material for catalytic water splitting. These results should inspire further experimental and theoretical research, aimed at fully exploring the potential applications of this new class of 2D materials.