bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced Semi-supervised Relation Extraction Based on Label Confusion Learning and Multisource Semantic Aggregation
Authors: Zhang Lei , Zhou Xiang , Yang Chengwei , Ding Xin , Wei Chuyuan
Published: January 2024

Knowledge Graph (KG) plays a significant role in the field of artificial intelligence. The search engines, intelligent recommendations, and various other domains such as architecture, finance, and healthcare rely on KG. KG is widely utilized to support decision-making and information retrieval. Relation Extraction(RE) is a crucial technique in constructing the KG. Traditional RE based on supervised learning demand a substantial amount of manually annotated data, leading to long processing times and high costs. The methods based on remote supervision and semi-supervised learning has the problem of label noise. To address these challenges, this paper proposes an innovative semi-supervised learning approach to model the relationships between labels and instances, and utilizes a novel label distribution to supervise model training. Additionally, by integrating entity location information and label information, the information of context representation is enriched. Extensive experiments on SemEval datasets prove that the proposed method outperforms the existing approaches.
Association of clinical indicators of acute deterioration and morbidity and mortality in the residential aged care population: a retrospective cohort study of routinely collected health data (interRAI-LTCF New Zealand)
Authors: Daltrey Julie , Boyd Michal , Burholt Vanessa , McLeod Heather , Wu Zhenqiang , Bloomfield Katherine , Robinson Jacqualine
Published: January 2024

Background: The timely identification of acute deterioration in people living in residential aged care is critical to avoiding or reducing rates of adverse events such as Emergency Department (ED) presentation or hospitalisation or death. This task is difficult as advanced age, multiple morbidity and frailty cause atypical or non-specific presentations of ill health. This study aimed to quantify the association between clinical indicators of acute deterioration reported in the literature and adverse events in his population.
Method: A retrospective cohort study using routinely collected health data. The cohort (n=5238) were aged 65 years or older in their last year of life and had an interRAI-LTCF assessment completed (I January to 31 December 2015). InterRAI-LTCF variables were matched with clinical indicators of acute deterioration reported in the literature. Univariate and multivariate logistic regression tested the association between those variables and ED presentation, hospitalisation or death 7 days or less from last completed interRAI-LTCF assessment.
Results: Nine clinical indicators, from four health domains were independently associated with acute deterioration. Cognitive indicators were being ‘largely asleep or unresponsive’odds ratio (OR) 7.95 95% CI 4.72-13.39, p<.001 and being ‘easily distracted; different to usual’ (OR 1.78 95% CI 1.28-2.49, p<.001). In the behavioural domain, eating ‘one or fewer meals a day’ (OR 2.13 95% CI 1.67-2.73, p<.001) and functional domain, a decline in activities of daily living status (OR 2.06 95% CI 1.11-3.82, p = .02) and not transferring to the toilet in the last three days (OR 1.95 95% CI 1.24-3.03, p = .004) were significant. Physical domain indicators were ‘dyspnoea; at rest’ (OR 1.81 5% CI 1.32-2.49, p<.001), ‘two or more falls in last 30 days’ (OR 1.53 95% CI 1.15-2.03, p = .003), daily peripheral oedema (OR 1.37 95 CI 1.07-1.77, p = .014) and daily pain (OR 1.37 95% CI 1.05-1.77, p = .019).
Conclusion and implication: Clinical indicators of acute deterioration reported in the literature are significantly associated with adverse events. This evidence is a first step towards the future development of tools to support residential aged care staff with the identification of acute deterioration.
Practice of cardioversion in a community hospital: feasibility, safety and immediate effectiveness
Authors: Okhotin Artemiy , Barchuk Anton , Osipov Vasiliy , Osipov Maxim
Published: January 2024

Background. Atrial fibrillation is the most prevalent sustained cardiac arrhythmia. Direct current cardioversion, a well-established part of the rhythm control strategy, is probably underused in community settings. Here, we describe its use, safety, and effectiveness in a cohort of patients with atrial fibrillation treated in rural settings.
Methods. It is a retrospective cohort study. Data on all procedures from January 1, 2016, till December 1, 2022, in Tarusa Hospital, serving mostly a rural population of 15,000 people, were extracted from electronic health records. Data on the procedure's success, age, gender, body mass index, comorbidities, previous procedures, echocardiographic parameters, type and duration of arrhythmia, anticoagulation, antiarrhythmic drugs, transesophageal echocardiography, and settings were available.
Results. Altogether, 1251 procedures in 430 patients were performed during the study period. The overall effectiveness of the procedure was 92\%. Effectiveness was similar across all prespecified subgroups. Direct current cardioversion was slightly less effective in patients undergoing the procedure for the first time (87%, 95% CI: 83--90 vs. 95%, 95% CI: 93--96 for repeated procedures). Complications were encountered in 15 (1.2%) procedures but were not serious.
Conclusions. Direct current cardioversion is an immediately effective procedure that can be safely performed in community hospitals in outpatient settings.
Conhecimentos docentes no âmbito do sistema Universidade Aberta do Brasil (UAB)
Authors: Veloso Braian , Mill Daniel
Published: January 2024

O objetivo deste artigo é investigar a constituição da base de conhecimento para o ensino dos docentes que atuam ou já atuaram na Educação a Distância (EaD) no âmbito do Sistema Universidade Aberta do Brasil (UAB). A pesquisa lançou mão da triangulação metodológica, que envolve múltiplos métodos, fontes de coleta e formas de análise. Nomeadamente, foram coletados dados por meio de questionários virtuais com 677 docentes. Posteriormente, foram realizadas entrevistas semiestruturadas com oito profissionais. A análise utilizou-se das abordagens quantitativa e qualitativa. Como resultados, a pesquisa identifica que os saberes e conhecimentos dos docentes são oriundos de diferentes fontes, a saber: experiência profissional, relação entre pares, pesquisas sobre a área, etc. Além disso, a base de conhecimento para o ensino dos docentes compreende conhecimentos de conteúdo, pedagógicos e tecnológicos, bem como o amálgama que se constitui na interseção entre eles. Portanto, o conhecimento tecnológico pedagógico do conteúdo (TPACK) é importante para compreender a atuação docente na EaD.
Phyto-fabrication of Cobalt Oxide Nanoparticles from Ocimum Gratissimum L. Leaf and Flower Extracts and their Antimicrobial Activities
Authors: Abdi Mohammed , Yusuf Zekeria , Sasikumar J. M.
Published: January 2024

Background:

Phyto-fabrication of nanoparticles has gained attention in recent times owing to its simple mode, cost-effective and eco-friendly nature.

Objective:

Hence, the present study aimed to synthesize cobalt oxide nanoparticles from methanol extracts of Ocimum gratissimum flower and leaf and to evaluate their antimicrobial action towards pathogenic bacteria and fungi.

Methods:

Phyto-fabrication of Cobalt nanoparticles (CoONPs) was achieved using cobalt chloride hydrate solution as a precursor. Characterization of fabricated CoONPs was performed using Ultra Violet-Visible spectrometry (UV-Vis), X-ray diffractometer (XRD), and Fourier Transform-Infrared spectroscopy (FTIR). The antimicrobial property was tested against two bacteria (Staphylococcus aureus and Escherichia coli) and two fungi (Cryptococcus albidus and Candida globasa) by agar disc diffusion technique and by measurement of Minimum Inhibitory Concentration (MIC).

Results:

Initial confirmation of CoONPs synthesis was observed by the colour change from light pink to reddish pink. Further, the UV-Vis spectrophotometry validated the CoONPs synthesis with a peak at 509 nm. The XRD authenticated the crystal nature of CoONPs synthesized using flower extract at 2θ angles with an average size of 54.9 nm and CoONPs fabricated using leaf extract at 2θ angles with an average size of 55.02 nm. The FTIR spectroscopy confirmed the functional groups present in plant extracts, which are believed to reduce and stabilize CoONPs. The findings of antibacterial activity showed that CoONPs synthesized using leaf showed a higher inhibition zone against E. coli (20.00 ± 2.00 mm) than S. aureus. Relating to fungi, the CoONPs fabricated using flower extract displayed significantly the highest activity against C. albidus (28.67±0.57 mm) and C. globasa (25.0 ± 0.00 mm). The lowest MIC was observed against S. aureus (MIC 7.5 µg/ml). For fungi, the smallest MIC was found against C. albidus (MIC 2.5 μg/ml).

Conclusion:

The current research established the efficacy of the phytochemical constituents of leaf and flower extracts of O. gratissimum for the enhancement of the effectiveness of CoONPs against both the tested bacteria and fungi.
Assessment of Causes Affecting Progress Schedules on Construction Investment Projects Funded by State Budget in Hanoi City, Vietnam
Authors: Hai Dinh Tuan
Published: January 2024

Background:

Hanoi, the capital city, is the economic, political, and cultural center of Vietnam. Every year, the City’s Government always spends a large part of the budget on construction investment in order to create a basis for promoting its economic development and improving the residents living standards. However, in the process of implementing investment and construction, many projects were delayed, leading to the failure to achieve the desired investment efficiency.

Objective:

To research and evaluate the causes affecting the progress schedules of construction projects using public investment capital in Hanoi, the authors conducted a survey and used the F-AHP method to analyze data collected data in order to obtain objective and accurate results on the research problem.

Methods:

The causes affecting the progress of construction projects are classified into four groups, including subjective causes from project participants and objective reasons.

Results:

The results show that the causes of the project participants have a stronger influence than the objective causes in which the causes related to the owner and the causes related to the contractor have the highest influence.

Conclusion:

Based on projects ‘ progress schedules, the resources are mobilized, the parties work together to promote the development of the project.
The Magnitude and associated factors of Helicobacter Pylori Infection among Dyspeptic Patients at the Arba Minch General Hospital in Southern Ethiopia
Authors: Alelign Dagninet , Furo Goshu , Degu Maykil , Tadesse Dagimawie , Kayta Gebre , Kidanewold Aschalew
Published: January 2024

Background:

Infection with Helicobacter pylori (H. pylori) is a major public health problem, with a higher prevalence reported in developing countries, including Ethiopia. Persistent H. pylori infection could result in chronic gastritis, duodenal ulcers, and subsequently gastric carcinoma. However, the burden of the infection varies within and between countries.

Methods:

An institution-based cross-sectional study was carried out on 422 adult dyspeptic patients attended at Arba Minch General Hospital from March 1st to June 30th, 2022. Pretested structured questionnaires were used to collect socio-demographic characteristics, clinical information, and other related factors for H. pylori infection. Stool samples were analyzed using the H. pylori fecal antigen rapid test kit. The data was analyzed using SPSS version 25. The p-value < 0.05 was considered statistically significant.

Results:

The overall magnitude of H. pylori was found to be 32.2% (136/422), with a 95% CI = (27.7-36.5). The highest proportion of H. pylori occurred in male study participants (55.1%) and in participants aged 31-40 years (42.6%). H. pylori stool antigen positivity was significantly associated with alcohol consumption [AOR = 1.87, 95% CI: (1.06-3.29)], smoking cigarettes [AOR = 2.75, 95% CI: (1.43-5.27)], and hand washing practice after the toilet [AOR = 3.02, 95% CI: (1.41-6.48)].

Conclusion:

Overall, a considerable magnitude of H. pylori was identified in the setting. Alcohol consumption, smoking cigarettes, and hand washing practice after using the toilet were found to be statistically significantly associated with H. pylori infection. Health education is therefore essential, particularly regarding societal lifestyle changes and knowledge of the potential sources of infection and H. pylori transmission.
Négyes arthrodesissel elért eredményeink a SNAC és a SLAC okozta csukló arthrosisok megoldásában
Authors: Ferenczy Botond Pál , Hetthéssy Judit Réka
Published: January 2024

A csuklót érő hatások esetén gyakran találkozhatunk a proximalis kéztőcsontsorban található sajkacsontot vagy környezetét érintő sérülésekkel. Az itt található összetett biomechanikai rendszer bármilyen okból történő megszakadása a csontok közötti konstrukció felbomlásához vezet, ami az arthrotikus folyamatok megindulását is magába foglalja. A sajkacsont törése vagy a scapholunaris szalag sérülése során létrejövő szerkezeti instabilitás két speciális arthrosis menetet hoz létre: a Scaphoid Nonunion Advanced Collapse (SNAC) és Scapholunate Advanced Collapse (SLAC) wrist-et. Mindkét deformitás esetében számos műtéti technika áll rendelkezésre, a különböző stádiumoktól függően. A műtéti megoldások közül lehetőleg kerülendő a teljes arthrodesis, mert a betegek számára a mozgástartomány teljes hiánya az életminőség romlásához vezet. Éppen ezért a cél mindig a mozgásmegtartó műtétek előtérbe helyezése, amelyek közé a négyes arthrodesis is tartozik. A 4CF alternatíva lehet a SNAC és SLAC wrist II. és III. stádiumában. A Semmelweis Egyetem Ortopédiai Klinika és az Országos Sportegészségügyi Intézet Sportsebészeti Osztály beteganyagának, illetve a szakirodalomban található eredmények alapján a négyes arthrodesis eredményeit vizsgáltuk a mindennapi tevékenységekhez, munkához szükséges mozgástartomány, erő és a funkcionális kézpanaszok tekintetében, releváns kérdőívek és mérések elvégzésével.
Hatástanulmány a nyeregízületi arthrosis intraarticularis hialuronsavas kezeléséről Sinoval HL® injekcióval
Authors: Hetthéssy Judit Réka , Hergár Luca
Published: January 2024

A nyeregízületi arthrosis az idősödő betegpopuláció gyakori, jelentős fájdalmakkal és a kézfunkció beszűkülésével járó megbetegedése. A progrediáló betegség kezelésében számos nyitott kérdés van, azonban az interdiszciplináris irodalomban egyetértés van abban, hogy a konzervatív terápiás eszközök maximális kihasználása javasolt. A Sinovial HL® intraarticularis injekció könnyű és nehéz molekulasúlyú hialuronsav láncok keverékét tartalmazza, a nyeregízületbe juttatva gyulladáscsökkentő és chondroprotektív tulajdonságokkal bír. A kutatás célja az injekció klinikai hatékonyságának vizsgálata volt. A kutatásba olyan nyeregízületi arthrosis miatt kezelt betegek lettek beválogatva, akiknél a radiológiai elváltozások mértéke alapján indokolt volt hialuronsavas terápia alkalmazása (Eaton–Littler stádium II–IV.) és a 6–8 hét első vonalbeli konzervatív terápia nem javított panaszaikon. A betegek panaszaiktól függően egy–három injekciót kaptak a nyeregízületbe. A beválogatott 21 beteg közül 20 esetben a panaszok jelentős javulást mutattak, további műtéti kezelés egy esetben vált szükségessé. A Sinovial HL® injekció hatékonyan alkalmazható a nyeregízületi arthrosis konzervatív kezelésében.
Moduláris térdprotézis rendszer alkalmazása nehéz primer szituációkban
Authors: Than Péter , Antal Hunor
Published: January 2024

Az endoprotetikai praxisban viszonylag gyakran találkozunk a rutin beültetéseknél lényegesen komolyabb technikai kihívást jelentő primer esetekkel. Ez különösen a csípőízületre igaz, de a térdprotetika is bővelkedik az ilyen jellegű szituációkban. Ezek a beavatkozások műtéttechnikai szempontból inkább a revíziókra hasonlítanak, ennek megfelelően csak bizonyos feltételek mellett valósulhatnak meg. Ide tartozik a csontpótlás és a speciális implantátumrendszerek elérhetősége, a sebészi felkészültség, valamint a szakmai és infrastrukturális háttér. Külön kérdésként merülnek fel a pénzügyi ráfordítás szempontjai, tekintettel arra, hogy a primer TEP hazai fedezete általában nem elegendő a fenti kritériumok biztosításához. Szerzők négy esetük kapcsán ismertetik a moduláris revíziós térdprotézis rendszer alkalmazhatóságát primer protetikában. Bemutatják a csonthiány, szalagelégtelenség és a frontális síkú deformitások megoldási módozatait és tárgyalják az implantátumválasztás szempontjait.
HEALTH CARE EDUCATION ON IMPORTANCE OF DENTURE THROUGH VIDEO ANIMATION IN DINOYO AND MOJOLANGU MALANG
Authors:   Department of Prosthodontic, Faculty of Dentistry, Universitas Brawijaya, Indonesia, Fatima Fatima , Hapsari Diwya Nugrahini , Irgananda Citra Insany , Wardani Sinta Candra ,   Department of Prosthodontic, Faculty of Dentistry, Universitas Brawijaya, Indonesia, Pratama Hafizh Haidar , Laksono Oswalda Rena Krismaningrat ,   Students of Faculty of Dentistry, Universitas Brawijaya, Indonesia
Published: January 2024

Teeth have an important function for human life in terms of aesthetics, mastication and speech functions. Losing some teeth or even all teeth can result in a reduction or loss of these functions. A person can use dentures made by a dentist to replace missing teeth, because losing teeth in the mouth if left too long has the potential to adversely affect the condition of other teeth. The purpose of this research is to increase public understanding of the importance of making dentures so as to minimize the risk of losing teeth. The design is Quasy experimental. Samples were taken using a purposive sampling technique, which is posyandu cadres at the Dinoyo Health Center and Mojolangu Health Center. Statistical data were analyzed using the Wilcoxon test. The results showed that education on the importance of making dentures in the community through animated videos at the Dinoyo and Mojolangu Health Centers showed good results. There was an increase in the pre-post test scores of the extension participants. Based on the statistical test, the value of sig p=0.000 was obtained, which means that there was a significant change. It can be concluded that education about the importance of making dentures in the community for posyandu cadres delivered through animated videos shows good results and significantly increases the participants' understanding of the importance of making dentures in the community.
Aplikasi Edible Coating Gel Lidah Buaya (Aloe vera L.) dengan Gliserol dan Tingkat Kematangan Terhadap Kualitas Cabai (Capsicum annum L.) Pasca Panen
Authors:   Universitas Syiah Kuala, Hayati Rita , Hasanuddin Hasanuddin ,   Universitas Syiah Kuala, Nasution Ummi Khairiah ,   Universitas Syiah Kuala
Published: January 2024

Cabai (Capsicum annum L.) merupakan salah satu hasil produk pertanian yang mudah rusak dan mempunyai daya simpan singkat yang disebabkan oleh kerusakan mekanis, fisik, fisiologis dan pembusukan. Salah satu upaya untuk mempertahankan kualitas cabai yaitu edible coating dengan menambahkan lidah buaya karena memiliki kelebihan dapat memperbaiki penampilan, mengurangi tingkat kebusukan, memperbaiki flavor, tekstur, dan warna. Edible coating perlu ditambahkan plasticizer yang berfungsi untuk mengatasi sifat kerapuhan lapisan coating, salah satu plasticizer yang dapat digunakan yaitu gliserol. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh aplikasi edible coating gel lidah buaya dengan gliserol, tingkat kematangan, dan bagaimana kedua faktor tersebut saling berinteraksi terhadap kualitas cabai pascapanen. Penelitian ini dilakukan dengan menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari dua variabel, yaitu variasi gel lidah buaya dengan gliserol dan tingkat kematangan. Pengamatan dilakukan selama dua puluh satu hari. Parameter yang diamati adalah susut bobot, kadar air, kadar vitamin C, pengukuran kejernihan warna, warna merah a, warna biru b, kadar capsaicin, uji organoleptik terhadap warna luar, tekstur, bau dan penerimaan umum. Terdapat interaksi antara edible coating gel lidah buaya dengan gliserol dan tingkat kematangan terhadap kualitas cabai pasca panen yang berpengaruh nyata terhadap kadar air, kadar vitamin C, warna L (kecerahan), warna a (merah), warna b (kuning), kadar capsaicin dan organoleptik pada aroma pada cabai. Perlakuan terbaik terdapat pada perlakuan 445 ml gel lidah buaya dengan 55 ml gliserol dengan tingkat kematangan merah.
Uji Eksperimental Kualitas Garam Berbasis Variasi Putaran Dan Waktu Pengadukan Pada Mesin Pengolahan Garam Kapasitas 25 kg/jam
Authors:   Universitas Ibn Khaldun Bogor, Hasibuan Musta'anul Husaini , Siregar Tika Hafzara ,   Universitas Ibn Khaldun Bogor, Sutoyo Edi ,   Universitas Ibn Khaldun Bogor, Sutisna Setya Permana ,   Universitas Ibn Khaldun Bogor
Published: January 2024

GAKI (Gangguan Akibat Kekurangan Iodium) merupakan masalah kesehatan serius yang menyebabkan kualitas hidup dan perkembangan individu. Uji Eksperimental terhadap kualitas kadar garam berbasis variasi putaran dan waktu pengadukan penting untuk membantu mencegah GAKI, dengan mempertahankan nilai baume dari air tua pencuci garam pada nilai 25-28. Penelitian ini bertujuan untuk menguji kualitas kadar garam yang dihasilkan oleh mesin pengolahan garam dengan variasi putaran (40, 80, dan 120 rpm) dan waktu pengadukan (10, 15, dan 20 menit) dengan kadar awal yang digunakan dalam penelitian sebesar 85.67%. Hasil penelitian menunjukkan bahwa variasi putaran dan lama pengadukan sangat berpengaruh terhadap kualitas kadar garam. Pada penelitian ini dapat disimpulkan bahwa kecepatan putaran mesin 120 rpm dan lama pengadukan dibawah 10 Menit mendapatkan kenaikan kadar garam yang optimal sebesar 6.88% menjadi 91.55%.
Julia Novak and Caitríona Ní Dhúill (eds.), Imagining Gender in Biographical Fiction
Authors: Layne Bethany
Published: January 2024

Taking its cue from Judith Butler’s definition of gender as ‘a practice of improvisation within a scene of constraint’ (2), this volume of essays sets out to explore biographical fiction’s innovations in gender, and also in genre. Deliberately avoiding ‘grand theor[ies]’ (3), the editors offer an understanding of genre as historically situated and in constant flux; like existing tropes of gender, concepts of genre are seen as available to biofiction’s rewritings.
Contract cheating in Z generation: Sociology of education review of academic fraud in Indonesia
Authors: Bhinekaswathi Deyanggi , Setiadi Elly Malihah , Ruyadi Yadi
Published: January 2024

Today, Z Generation around the world including Indonesia have engaged in a form of academic fraud namely “contract cheating”. It is a phenomenon that occurred when students ask others to finished the assignments which is given by their teachers or lecturers. Contract cheating is a serious problem as it relates to educational norms and ethics. The research focuses on contract cheating that occurs on social media among generation Z in Indonesia by offering views that adopt the sociology of education. Technical data collection is carried out by means of documentation to social media such as Intagram, Twitter, and Telegram as well as reviewing book libraries, journals, and websites. The results of the research suggest that 1) contract cheating is a type of academic fraud; 2) students who engage in contract cheating are violating academic norms and ethics; and 3) improvements to the education system are needed to address the problem of contract cheating.
An evaluation of the flip flop approach to combating terrorism and religious extremism in Nigeria from 2015-2022
Authors: Ighoshemu Ogheneakpoje Benedict , Orhero Abraham , Sanubi Franklin
Published: January 2024

The fundamental responsibility of government is to secure citizens life and properties. The ongoing terrorist activities and religious extremism in Nigeria is yet to receive the required attention from the government. In light of the growing influence of terrorism and religious extremism in Nigeria, the study adopted the relative deprivation theory, to explain possible causes of terrorism and the recruitment of terrorists. The paper examines the ideological variations among the terrorist groups, using the quantitative textual analysis of secondary data to evaluate and scrutinize the flip flop approach of the Nigeria government from 2015 to 2022 in combating terrorism and religious extremism in the country. Despite the response by government, insecurity, terrorism and religious extremism have not been defeated due to lack of political will and the inability of government to make good laws to sanction offenders, thus, endemic poverty encourages the spread of terrorism and religious extremism. The study recommend among others, the need for government to properly police the borders, religious or tribal nepotism should not be condoled and not until systematic corruption, bad governance, inter religious and ethnic rivalry aimed at the control of state apparatus for economic and political selfish gains are seriously addressed and curtailed. The paper suggests that acute poverty and relative deprivation are precursor to the serial insecurity and terrorism that Nigeria is facing today.
“I am blaming you!” a case of Instagram’s news and moral panic of paracetamol consumption and children’s chronic kidney in Indonesia
Authors: Indreswari Esfandani Peni
Published: January 2024

In terms of obtaining information people nowadays depend on the use of social media such as Instagram due to its ease of access. This routine has also changed media institutions in disseminating information, which is through their social media account for audience engagement and news distribution to survive in the information technology era. This research focuses on news dissemination through Instagram on health communication. It was found that such means through Instagram caused a moral panic among the audience. The health issue put in the spotlight of this research is paracetamol and chronic kidney in children, actively reported in October-November 2023 in Indonesia. The result showed moral panic materialized from incomplete information due to limited sentences. Other factors are building personal assumptions, blaming other parties, to distortion of information. This study uses the netnographic method on Instagram posts on @kompascom social media news account. The research is carried out in several stages consisting of investigation, interaction, immersion, and integration. This was conducted to see the culture of social media users of the news account. The data consisted of 162 comments from 6 news posts on @kompascom.
The ideal Muslim: Interpreting construction of new self standards in @ukhtiakhiantiselfie Instagram account
Authors: Aini Syarifah Nur , Akalili Awanis , Setiawan Benni
Published: January 2024

Media as a medium of construing discourse, for example a dominant figure religion. In Islam the ideal muslim shown by the media that has a role as a medium for forming new ideologies in religious aspects. This research aims to explore the ideal Muslim discourse on the Instagram social media account @ukhtiakhiantiselfie. This research uses a qualitative method with content analysis in the form of Norman Fairclough's critical discourse analysis and focuses on the level of text presented in the content on the Instagram social media account @ukhtiakhiantiselfie. To find out the extent of the truth of the research, the author uses data validity techniques in the form of triangulation of data sources. Meanwhile, data analysis techniques consist of data selection, interpretation and interpretation of the text, data presentation and discussion, to draw conclusions. The results of this study indicate that the ideology constructed in the Instagram account @ukhtiakhiantiselfie is in the form of a ban on uploading photos to social media for men (muslimin) and women (muslimah). In addition, there is an ideal Muslim standard for Muslims, namely individuals who do not upload photos of themselves, achievements, possessions, and others to the public via social media. Meanwhile, the discourse that is presented refers to the ideal Muslim character according to Hamka in the form of istiqomah, namely showing firm actions towards the establishment and carrying out the commands of Allah SWT and avoiding His prohibitions. The results of this research show that the ideology constructed in the Instagram account @ukhtiakhiantiselfie is a prohibition on uploading photos to social media for men (Muslims) and women (Muslimah). Apart from that, there is an ideal Muslim standard for Muslims, namely individuals who do not upload photos of themselves, their achievements, possessions and so on to the public via social media. Meanwhile, the discourse presented refers to the ideal Muslim characteristic according to Hamka in the form of istiqomah, namely showing firm actions towards standing and carrying out the commands of Allah SWT and staying away from His prohibitions. The results of this research show that the ideology constructed in the Instagram account @ukhtiakhiantiselfie is a prohibition on uploading photos to social media for men (Muslims) and women (Muslimah). Apart from that, there is an ideal Muslim standard for Muslims, namely individuals who do not upload photos of themselves, their achievements, possessions and so on to the public via social media. Meanwhile, the discourse presented refers to the ideal Muslim characteristic according to Hamka in the form of istiqomah, namely showing firm actions towards standing and carrying out the commands of Allah SWT and staying away from His prohibitions.
Site Readiness Index for Implementing Industry 4.0 based on the Design Principles and Emerging Manufacturing Technologies
Authors:   Helwan University, Garbie Ibrahim , Parsaei Hamid ,   Texas A&M University, Garbie Muhammad ,   Texas Tech University
Published: January 2024

Nowadays, Implementing Industry 4.0 (I4.0) has become an urgent mandate in manufacturing enterprises to increase the efficiency and effectiveness of production processes. Six design principles (DP) must be considered to meet the challenges of integrating I4.0 beside the emerging advanced manufacturing technologies (AMT). This paper summarizes the analysis and investigation into the importance of I4.0 side readiness that enables the customization of AMT with the DP. The principal aim of this paper is to support manufacturing enterprises by incorporating AMT with the DP, thus helping these enterprises identify their specific requirements for implementing industry 4.0/ smart manufacturing. A model of estimating side readiness by adopting the DP incorporating customizing AMT is also analyzed and presented. The side readiness index towards implementing I4.0 is assessed and illustrated through a numerical example.
Development and Clinical Applications of PI3K/AKT/mTOR Pathway Inhibitors as a Therapeutic Option for Leukemias
Authors: DA COSTA MACHADO ANNA KAROLYNA , MACHADO CAIO BEZERRA , DE PINHO PESSOA FLÁVIA MELO CUNHA , BARRETO IGOR VALENTIM , GADELHA RENAN BRITO , DE SOUSA OLIVEIRA DEIVIDE , MONTEIRO RIBEIRO RODRIGO , SILVA LOPES GERMISON , DE MORAES FILHO MANOEL ODORICO , AMARAL DE MORAES MARIA ELISABETE , KHAYAT ANDRÉ SALIM , MOREIRA-NUNES CAROLINE AQUINO
Published: January 2024

Leukemias are hematological neoplasms characterized by dysregulations in several cellular signaling pathways, prominently including the PI3K/AKT/mTOR pathway. Since this pathway is associated with several important cellular mechanisms, such as proliferation, metabolism, survival, and cell death, its hyperactivation significantly contributes to the development of leukemias. In addition, it is a crucial prognostic factor, often correlated with therapeutic resistance. Changes in the PI3K/AKT/mTOR pathway are identified in more than 50% of cases of acute leukemia, especially in myeloid lineages. Furthermore, these changes are highly frequent in cases of chronic lymphocytic leukemia, especially those with a B cell phenotype, due to the correlation between the hyperactivation of B cell receptors and the abnormal activation of PI3Kδ. Thus, the search for new therapies that inhibit the activity of the PI3K/AKT/mTOR pathway has become the objective of several clinical studies that aim to replace conventional oncological treatments that have high rates of toxicities and low specificity with target-specific therapies offering improved patient quality of life. In this review we describe the PI3K/AKT/mTOR signal transduction pathway and its implications in leukemogenesis. Furthermore, we provide an overview of clinical trials that employed PI3K/AKT/mTOR inhibitors either as monotherapy or in combination with other cytotoxic agents for treating patients with various types of leukemias. The varying degrees of treatment efficacy are also reported.
Precise Non-invasive Imaging Mouse Model of Pancreatic Cancer: Very Narrow Band-width Laser Fluorescence Excitation of Green Fluorescent Protein Provides Ultra-bright Tumor Images With no Skin Autofluorescence
Authors: KUBOTA YUTARO , WANG APRIL , CHANG NEIL , TARANTINO SAMANTHA , GALLAGHER SEAN , AOKI YUSUKE , MASAKI NORIYUKI , OBARA KOYA , MORINAGA SEI , TSUNODA TAKUYA , HOFFMAN ROBERT M.
Published: January 2024

Background/Aim: Pancreatic cancer is a recalcitrant disease with 5-year survival of only 12%. Improved mouse models of pancreatic cancer are critical for discovery of effective therapeutics. Materials and Methods: Orthotopic mouse nude-mouse models of pancreatic cancer were established with the human pancreatic-cancer cell line Panc-1 expressing green fluorescent protein (GFP) by transplanting tumor fragments into the pancreas, using the procedure of surgical orthotopic implantation (SOI). Four weeks after establishment of the orthotopic models, the mice were imaged with the Analytik Jena UVP Biospectrum Advanced with a very-narrow-band-width excitation at 487 nm and peak emission at 513 nm. Results: Non-invasive fluorescence imaging of the mice implanted with Panc-1-GFP showed a very bright tumor in the area of the pancreas and peritoneal cavity. The skin background autofluorescence was absent. When a laparotomy was performed on the mouse for open imaging, the tumor on the pancreas was clearly imaged. There was very clear concordance of the non-invasive image and the image obtained during laparotomy. Conclusion: A precise orthotopic mouse model of pancreatic cancer was developed in which there was high concordance between non-invasive and invasive fluorescence imaging due to the ultra-bright signal and ultra-low background using very-narrow-band-width laser fluorescence excitation. This model can be used for high-throughput in vivo screening for improved therapeutics for pancreatic cancer.
Three Dimensional (3D) Laparoscopic Nephron-sparing Treatment of a Huge Cystic Nephroma: A Case Report and Literature Review
Authors: TSAKIRIS SAVVAS , ZERVA MARIA , PAPARIDIS SPYRIDON , GASPAROS FOTIS , TZORAS AGGELOS , SAMIS ALEXANDROS , BOUROPOULOS CONSTANTINOS , FERAKIS NIKOLAOS
Published: January 2024

Background/Aim: Cystic nephroma (CN) is a very rare, benign, renal cystic lesion, which is characterized by a usually unilateral, multicystic kidney mass. In adults it is seen more frequently in females (1:8 male-to-female ratio). The peak incidence of CN is between 50 and 60 years of age. Median age at diagnosis is 55 years for females and 44 years for men and it is a rare entity in adults under 30 years of age. Case Report: We report the case of a 52-year-old female patient with chronic right-flank pain, who was treated at our hospital. A multiloculated 10×8.6 cm Bosniak IV renal cyst tumor was depicted on retroperitoneal computed tomography. After a three-dimensional laparoscopic partial nephrectomy, the histopathological specimen examination revealed: a multilocular cystic nephroma. Conclusion: CNs are rare benign tumors that should be included in the differential diagnosis when treating large multiloculated complex renal cysts.
Investigation of the Association Between e-Cigarette Smoking and Oral Mucosal Health Status Among Young People: Protocol for a Case-Control Trial
Authors: Cheng Siyuan
Published: January 2024

Background

Given the paucity of current safety studies related to e-cigarettes, there are no definitive studies on whether e-cigarettes cause oral mucosal lesions or even oral cancer. Although it is still undetermined whether e-cigarettes are harmless, an increasing number of teenagers choose to smoke e-cigarettes and believe that they are not harmful to the human body.

Objective

This aims to determine whether e-cigarettes cause damage to the oral mucosa. This study also aims to evaluate the association between e-cigarette smoking and oral mucous membrane lesions in young adults. The objectives are to (1) compare the oral mucosal conditions in participants with and without e-cigarette smoking habits, (2) assess the effect of the amount of e-cigarette smoking on oral mucosal conditions, and (3) assess the effect of the duration of e-cigarette smoking on oral mucosal conditions.

Methods

In this prospective study, 304 youths aged 15 to 24 years (n=152, 50% who smoke only e-cigarettes and n=152, 50% who do not smoke e-cigarettes or cigarettes) will be divided into 2 groups for a controlled study. Whether e-cigarettes cause oral mucosal lesions will be verified by comparing the odds of oral mucosal lesions in the 2 experimental groups. For this experiment, the predefined power is 80% (P=.04), and the predefined proportions of groups 1 and 2 are 11% and 2.5%, respectively.

Results

This experiment is at the conceptualization phase and has not yet been carried out. Experimenters have not been recruited and no data have been collected.

Conclusions

e-Cigarettes are still an unfamiliar topic to the public, and it is still unknown whether they can cause damage to the oral mucosa. This experiment aims to find out whether there is a link between the 2. There are still many limitations in this study, such as the lack of categorization of e-cigarettes and the lack of testing methods for oral mucosal status. These limitations are expected to be addressed in the future as the experiment is formally conducted and further optimized.

International Registered Report Identifier (IRRID)

PRR1-10.2196/53644
Editorial
Authors: Husein Ahmad
Published: January 2024

Editorial board Volume 25 Issue 2 2023
(Non-Formal) Collaborative Governance is Possible
Authors: Febry Savira Noor
Published: January 2024

Kolaborasi pemerintah dengan masyarakat dapat mempermudah pemerintah dalam menjalankan pemerintahan melalui collaborative governance. Kajian ini melihat terdapat kelompok masyarakat yang menjadi kolaborator non-formal dan membantu pemerintah menyelesaikan masalah pendidikan. Dalam hal ini, kolaborator dan pemerintah memiliki fokus isu yang sama, yaitu learning loss di tengah pandemi Covid-19, namun tidak terikat kontrak kerja sama resmi, yang akan disebut dengan non-formal collaborative governance. Salah satu contohnya peran Project Child Indonesia (PCI) sebagai lembaga swadaya masyarakat yang fokus dengan isu pendidikan di akar rumput. Kajian di sini berusaha melihat tahapan non-formal collaborative governance yang diinisiasi oleh PCI dan apa saja tantangan maupun kendala yang dihadapi. Kajian di sini menggunakan metode netnografi dengan dua sumber data, yaitu observasi daring selama satu bulan pada 12 April 2022 hingga 19 Mei 2022 dan wawancara. Sejak pandemi Covid-19 masuk ke Indonesia, negara menghadapi permasalahan baru di berbagai sektor, salah satunya sektor pendidikan yang membutuhkan penyesuaian. PCI berusaha merespons kondisi ini dengan cepat tanpa melalui proses birokrasi yang panjang. PCI menerapkan program pembelajaran jarak jauh dengan kurikulum yang ditetapkan oleh pemerintah serta menyesuaikan program dengan kebutuhan masyarakat dengan melakukan survei sebelum dan sesudah program dilakukan. Tahapan yang lebih sederhana dan fleksibilitas menjadi keunggulan dari model non-formal collaborative governance.
Effects of Fiberglass on the Strength of Reclaimed Asphalt Pavement (RAP) as a Subbase Materials
Authors: A. Mostafa Ahmed Mahmoud , M. Morsi Ahmed Gamal , E. Hegazy Alnos Aly
Published: January 2024

This research study investigates the effect of fiberglass content on the strength of Reclaimed Asphalt Pavement (RAP) material as a subbase layer of flexible pavement. Laboratory modified proctor and California bearing ratio (CBR) tests were conducted on the mixture of RAP and fiberglass. The obtained results show that, 100% RAP material can be used as subbase material. In addition to that, there is a slight reduction in maximum dry density (γdmax) values when RAP is blended with fiberglass. Similarly, the soaked and unsoaked CBR values of the mixture decreased slightly. However, the mixture of RAP and fiberglass achieved the specification requirements as a subbase layer according to the Egyptian specifications. The relationship between fiberglass content and maximum dry density of RAP is found to be linear. Also, a linear relationship exists between percentage of fiberglass and unsoaked CBR. Finally, the relationship between the percentage of fiberglass and soaked CBR is found to be nonlinear.
The Symbolism of Double Consciousness in the Works of W.E.B. Du Bois and its Evolution in Contemporary Black Literature
Authors: S Neethu
Published: January 2024

This research paper traverse into the concept of double consciousness as presented by W.E.B. Du Bois in his seminal work The Souls of Black Folk and explores how this theme has been redefined and adapted in contemporary black literature. The study examines the symbolic use of double consciousness in characters, narratives, and motifs, tracing its evolution as a literary device and its continued relevance in the portrayal of black identity and experience. Through an in-depth analysis of selected works spanning different periods, the research aims to shed light on the ways in which black writers have engaged with and transformed this concept to reflect the complexities of black life in diverse sociocultural contexts.
Innovative Complex Coacervates of Gelatin and Sodium Carboxymethyl Cellulose for Cinnamaldehyde Delivery: Impact of Processing Conditions on Characteristics and Bioactivity
Authors: Abdulla Mahran , Xia Shuqin
Published: January 2024

Cinnamaldehyde (CA) has a special flavor, and numerous bioactivities; nevertheless, it possesses a high level of volatility, low solubility in water, and limited stability. To address the shortcomings of CA and enhance its use in foods, CA-loaded microcapsules were created by complex coacervation. Gelatin (GL) and carboxymethyl cellulose (CMC) were used as the wall materials of CA. Ideal conditions for obtaining encapsulation efficiency and morphology were found for core/wall ratio 1:1 (w: w), and an emulsification speed 15,000 rpm. The optimized microcapsule formulation demonstrates an encapsulation efficacy of 87.949 ± 1.229 % for CA with payload 41.276 ± 4.189% and a size of 26.093 ± 0.575μm. The examination of Fourier-transform infrared (FTIR) spectra of GL, CMC, GL-CMC complex coacervates and CA microcapsules exhibited an electrostatic attraction among GL and CMC molecules and the creation of hydrogen bonds among core (CA) and shell materials. When 1:1 core: wall ratio and 9000 rpm emulsification speed utilized in the microencapsulation of CA, the thermal stability significantly enhanced, possessed a slow-release property in ethanol 50%, and enhanced the antibacterial activity of CA.
The Grotesque in Kafka: A study of the other in Kafka’s ‘Metamorphosis’
Authors: Dhupkar Jaiwantika Dutta
Published: January 2024

In Kafka, The Other takes on an alien and otherworldly form. Gregor Samsa, Kafka’s protagonist in the ‘Metamorphosis’, leads an uneventful life until his transformation into a grotesque monster incites the worst in his family. According to Bakhtin, the grotesque in literature and art was used as a form of satire to question the hypocrisy and hegemony of the dominant class. In ‘Metamorphosis’,Gregor morphs into an interstitiality that his family finds extremely threatening. He is no more their own, he is The Other and his grotesqueness is proof of this fact. In this paper, we study the relationship between grotesqueness and The Other in Kafka’s ‘Metamorphosis’.
The Age of Toxicity: A Theoretical Model
Authors: Malaviya Ritambhara
Published: January 2024

Ulrich Beck theorized the contemporary world as the ‘age of risk’. Taking the cue from Beck, this paper focuses on the ecological aspect of this risk society which looms large over the life and wellbeing of the entire planet – the intrusion of toxics in our everyday lives – thereby also making it the ‘age of toxicity’. Toxics have permeated the entire ecosystem – from land to water to atmosphere – making it difficult for any life form to escape their impact. The paper attempts to explain the main features of this age of toxicity in an effort to find solutions to this problem. It might be noted that the problem of toxicity is not evenly distributed across the countries and the Global South bears the brunt of the problem. Further, toxicity has a disproportionate impact on the economically weaker and marginalized sections within the developing countries as they are forced by economic circumstances to live in areas which are environmentally degraded and polluted. The paper proposes that toxicity is engendered within a global system structured by three factors– international power conflicts, activities of corporate houses and the consumerist culture – which together create a vicious circle of toxicity. The paper therefore proposes that the concerned civil society groups could advocate policies aimed at weakening this vicious circle of toxicity and campaign for small steps in the direction of larger changes.
Synergizing Sustainability: Recycling Food Waste for Plant Fertilizer Production and Unveiling Ecological Dynamics
Authors: Kansoriya Nidhi
Published: January 2024

Abstract: This research presents a comprehensive investigation into the environmental sustainability of recycling practices, plant health dynamics, soil composition variations, and water quality parameters. Utilizing synthetic data generated through a Google Form, the study explores the intricate relationships among these factors. The first segment focuses on recycling efficiency, employing an independent samples t-test to discern mean differences between 'Kitchen Waste' and 'Sawdust,' followed by a oneway ANOVA that delves into recycling efficiency variations among diverse feedstock types. The second segment elucidates plant variations, employing a one-way ANOVA to uncover patterns in nutrient content across different plant types and a regression analysis to unveil the quantitative relationships between plant characteristics and nutrient content. The third segment scrutinizes soil composition, utilizing a one-way ANOVA to identify significant differences in organic carbon content among various soil types. A cross-tabulation explores the intricate relationships between soil texture and soil type, while a correlation analysis delves into interdependencies among organic carbon, moisture content, water holding capacity, and pH level in the soil. The fourth segment investigates water quality parameters, employing a one-way ANOVA to unveil differences in BOD among distinct water sources and a correlation analysis that provides a holistic exploration of interrelationships among key water quality parameters. The synthesis of these analyses contributes to a nuanced understanding of environmental dynamics, paving the way for informed sustainability practices. The research not only advances our knowledge of individual factors but also provides a holistic perspective on their interplay, offering valuable insights for policymakers, environmental scientists, and practitioners aiming to enhance ecological well-being.