bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Silica Shell Encapsulated Nanocrystals on Active χ-Fe5C2 Phase and Fischer–Tropsch Synthesis
Authors: Cha Seunghee , Kim Heewon , Choi Hyunkyung , Kim Chul Sung , Ha Kyoung-Su
Published: October 2022

Among various iron carbide phases, χ-Fe5C2, a highly active phase in Fischer–Tropsch synthesis, was directly synthesized using a wet-chemical route, which makes a pre-activation step unnecessary. In addition, χ-Fe5C2 nanoparticles were encapsulated with mesoporous silica for protection from deactivation. Further structural analysis showed that the protective silica shell had a partially ordered mesoporous structure with a short range. According to the XRD result, the sintering of χ-Fe5C2 crystals did not seem to be significant, which was believed to be the beneficial effect of the protective shell providing restrictive geometrical space for nanoparticles. More interestingly, the protective silica shell was also found to be effective in maintaining the phase of χ-Fe5C2 against re-oxidation and transformation to other iron carbide phases. Fischer–Tropsch activity of χ-Fe5C2 in this study was comparable to or higher than those from previous reports. In addition, CO2 selectivity was found to be very low after stabilization.
Electronic Transport in Weyl Semimetals with a Uniform Concentration of Torsional Dislocations
Authors: Bonilla Daniel , Muñoz Enrique
Published: October 2022

In this article, we consider a theoretical model for a type I Weyl semimetal, under the presence of a diluted uniform concentration of torsional dislocations. By means of a mathematical analysis for partial wave scattering (phase-shift) for the T-matrix, we obtain the corresponding retarded and advanced Green’s functions that include the effects of multiple scattering events with the ensemble of randomly distributed dislocations. Combining this analysis with the Kubo formalism, and including vertex corrections, we calculate the electronic conductivity as a function of temperature and concentration of dislocations. We further evaluate our analytical formulas to predict the electrical conductivity of several transition metal monopnictides, i.e., TaAs, TaP, NbAs, and NbP.
Cathodoluminescence Spectroscopy in Graded InxGa1−xN
Authors: Zhao Xiaofang , Wang Tao , Sheng Bowen , Zheng Xiantong , Chen Li , Liu Haihui , He Chao , Xu Jun , Zhu Rui , Wang Xinqiang
Published: October 2022

InGaN materials are widely used in optoelectronic devices due to their excellent optical properties. Since the emission wavelength of the full-composition-graded InxGa1−xN films perfectly matches the solar spectrum, providing a full-spectrum response, this makes them suitable for the manufacturing of high-efficiency optoelectronic devices. It is extremely important to study the optical properties of materials, but there are very few studies of the luminescence of full-composition-graded InxGa1−xN ternary alloy. In this work, the optical properties of full-composition-graded InxGa1−xN films are studied by cathodoluminescence (CL). The CL spectra with multiple luminescence peaks in the range of 365–1000 nm were acquired in the cross-sectional and plan-view directions. The CL spectroscopy studies were carried out inside and outside of microplates formed under the indium droplets on the InGaN surface, which found that the intensity of the light emission peaks inside and outside of microplates differed significantly. Additionally, the paired defects structure is studied by using the spectroscopic method. A detailed CL spectroscopy study paves the way for the growth and device optimization of high-quality, full-composition-graded InxGa1−xN ternary alloy materials.
Nb and Ni Nanoparticles Anchored on N-Doped Carbon Nanofiber Membrane as Self-Supporting Anode for High-Rate Lithium-Ion Batteries
Authors: Zhang Yezheng , Zhang Shan , Zhao Shuo , Cui Yingxue , Lian Jiabiao , Li Guochun
Published: October 2022

A flexible N-doped carbon nanofiber membrane loaded with Nb and Ni nanoparticles (Nb/Ni@NC) was prepared using electrospinning technology and a subsequent thermal annealing method and used as a self-supporting anode material for lithium-ion batteries. The Nb/Ni@NC nanofiber membrane had excellent flexibility and could be folded and bent at will without fragmentation and wrinkling; the nanofibers also had a uniform and controllable morphology with a diameter of 300–400 nm. The electrochemical results showed that the flexible Nb/Ni@NC electrode could deliver a high discharge capacity of 378.7 mAh g−1 after 200 cycles at 0.2 A g−1 and an initial coulombic efficiency of 67.7%, which was higher than that of the pure flexible NC anode in contrast. Moreover, a reversible discharge capacity of 203.6 mAh g−1 after 480 cycles at 1.0 A g−1 was achieved by the flexible Nb/Ni@NC electrode with a capacity decay for each cycle of only 0.075%, which showed an excellent rate capability and cycling stability.
Enhanced NO2 Sensing Performance of ZnO-SnO2 Heterojunction Derived from Metal-Organic Frameworks
Authors: Ren Xiaowei , Xu Ze , Zhang Zhongtai , Tang Zilong
Published: October 2022

Nitrogen dioxide (NO2) is the major reason for acid rain and respiratory illness in humans. Therefore, rapid, portable, and effective detection of NO2 is essential. Herein, a novel and simple method to construct a ZnO-SnO2 heterojunction is fabricated by pyrolysis of bimetallic metal organic frameworks. The sensitivity of ZnO-SnO2 heterojunction towards 0.2 ppm NO2 under 180 °C is 37, which is 3 times that of pure ZnO and SnO2. The construction of heterojunction speeds up the response-recovery process, and this kind of material exhibits lower detection limit. The construction of heterojunction can significantly improve the NO2 sensitivity. The selectivity, stability, and moisture resistance of ZnO-SnO2 heterojunction are carried out. This could enable the realization of highly selective and sensitive portable detection of NO2.
Electrostatic and Environmental Control of the Trion Fine Structure in Transition Metal Dichalcogenide Monolayers
Authors: Zhumagulov Yaroslav V. , Vagov Alexei , Gulevich Dmitry R. , Perebeinos Vasili
Published: October 2022

Charged excitons or trions are essential for optical spectra in low-dimensional doped monolayers (ML) of transitional metal dichalcogenides (TMDC). Using a direct diagonalization of the three-body Hamiltonian, we calculate the low-lying trion states in four types of TMDC MLs as a function of doping and dielectric environment. We show that the fine structure of the trion is the result of the interplay between the spin-valley fine structure of the single-particle bands and the exchange interaction. We demonstrate that by variations of the doping and dielectric environment, the fine structure of the trion energy can be tuned, leading to anticrossing of the bright and dark states, with substantial implications for the optical spectra of the TMDC ML.
Effects of Diamond on Microstructure, Fracture Toughness, and Tribological Properties of TiO2-Diamond Composites
Authors: Liu Bing , Zhuge Zewen , Zhao Song , Zou Yitong , Tong Ke , Sun Lei , Wang Xiaoyu , Liang Zitai , Li Baozhong , Jin Tianye , Chen Junyun , Zhao Zhisheng
Published: October 2022

The reinforcements represented by graphene nanoplatelets, graphite, and carbon nanotubes have demonstrated the great potential of carbon materials as reinforcements to enhance the mechanical properties of TiO2. However, it is difficult to successfully prepare TiO2-diamond composites because diamond is highly susceptible to oxidation or graphitization at relatively high sintering temperatures. In this work, the TiO2-diamond composites were successfully prepared using high-pressure sintering. The effect of diamond on the phase composition, microstructure, mechanical properties, and tribological properties was systemically investigated. Diamond can improve fracture toughness by the crack deflection mechanism. Furthermore, the addition of diamond can also significantly reduce the friction coefficient. The composite composed of 10 wt.% diamond exhibits optimum mechanical and tribological properties, with a hardness of 14.5 GPa, bending strength of 205.2 MPa, fracture toughness of 3.5 MPa∙m1/2, and a friction coefficient of 0.3. These results enlarge the family of titania-based composites and provide a feasible approach for the preparation of TiO2-diamond composites.
Handwriting in Autism Spectrum Disorder: A Literature Review
Authors: Handle Henriette C. , Feldin Marcus , Pilacinski Artur
Published: October 2022

Handwriting is linked to a variety of systems in the human brain and has been likewise demonstrated to be affected by a variety of neurological and developmental disorders. In this paper we provide a narrative review of recent findings regarding the quantitative evaluation of handwriting product in people with autism spectrum disorder. We summarize the experimental approaches and variables measured by most representative studies, such as handwriting speed and quality. We highlight the key issues such as small sample sizes resulting in underpowered designs. Lastly, we draw conclusions and delineate potential research directions, such as the use of machine learning to evaluate multivariate components of handwriting.
How Repeatable Is the Ergogenic Effect of Caffeine? Limited Reproducibility of Acute Caffeine (3 mg.kg−1) Ingestion on Muscular Strength, Power, and Muscular Endurance
Authors: Tamilio Ryan A. , Clarke Neil D. , Duncan Michael J. , Morris Rhys O. , Tallis Jason
Published: October 2022

This study aimed to determine the effect of 3 mg.kg−1 acute caffeine ingestion on muscular strength, power and strength endurance and the repeatability of potential ergogenic effects across multiple trials. Twenty-two university standard male rugby union players (20 ± 2 years) completed the study. Using a double-blind, randomized, and counterbalanced within-subject experimental design. Participants completed six experimental trials (three caffeine and three placebo) where force time characteristic of the Isometric Mid-Thigh Pull (IMTP), Countermovement Jump (CMJ) and Drop Jumps (DJ) were assessed followed by assessments of Chest Press (CP), Shoulder Press (SP), Squats (SQ), and Deadlifts (DL) Repetitions Until Failure (RTF at 70% 1 RM). ANOVA indicated that caffeine improved both the CMJ and DJ (p < 0.044) and increased RTF in all RTF assessments (p < 0.002). When individual caffeine trials were compared to corresponding placebo trials, effect sizes ranged from trivial-large favoring caffeine irrespective of a main effect of treatment being identified in the ANOVA. These results demonstrate for the first time that the performance enhancing effects of caffeine may not be repeatable between days, where our data uniquely indicates that this is in part attributable to between sessions variation in caffeine’s ergogenic potential.
Fibre Intake in Chronic Kidney Disease: What Fibre Should We Recommend?
Authors: Cigarrán Guldris Secundino , Latorre Catalá Juan Antonio , Sanjurjo Amado Ana , Menéndez Granados Nicolás , Piñeiro Varela Eva
Published: October 2022

Chronic kidney disease (CKD) is a major global health problem that challenges all patients’ healthcare needs. Fibre consumption benefits kidney patients by acting preventively on associated risk factors, improving intestinal microbiota composition or reducing metabolic acidosis and inflammation. In this review, we focus on increasing fibre consumption and the quality of fibre to recommend, in addition to increasing the consumption of foods that naturally have it in their design, that can resort to fortified foods or fibre supplements. The Western nutritional practice, which is low in fibre and rich in animal proteins, saturated fats, sodium, and sugar, increases the risk of mortality in these patients. On the contrary, patterns with higher consumption of fibre and vegetable proteins, such as the Mediterranean, vegetarian, or Plant dominant low protein diet (PLADO), seem to have a preventive effect on the associated risk factors and influence CKD progression. Until now, the use of fibre supplements has not achieved an evident impact on clinical results. Fibre-rich foods contain other nutrients that reduce cardiovascular risk. Promoting diets richer in vegetables and guaranteeing adequate energy and protein intake is a challenge for the multidisciplinary teams involved in the standard of care for CKD.
Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits
Authors: Carter R. Colin , Dodge Neil C. , Molteno Christopher D. , Meintjes Ernesta M. , Jacobson Joseph L. , Jacobson Sandra W.
Published: October 2022

We have previously demonstrated prenatal alcohol exposure (PAE)-related alterations in maternal and infant iron homeostasis. Given that early iron deficiency and PAE both lead to growth restriction and deficits in recognition memory and processing speed, we hypothesized that PAE-related iron homeostasis alterations may mediate and/or moderate effects of PAE on growth and neurobehavior. We examined this hypothesis in a prenatally recruited, prospective longitudinal birth cohort [87 mother-infant pairs with heavy prenatal alcohol exposure (mean = 7.2 drinks/occasion on 1.4 days/week); 71 controls], with serial growth measures and infant neurobehavioral assessments. PAE was related to growth restriction at 2 weeks and 5 years, and, in infancy, poorer visual recognition memory, slower processing speed, lower complexity of symbolic play, and higher emotionality and shyness on a parental report temperament scale. Lower maternal hemoglobin-to-log(ferritin) ratio, which we have shown to be associated with PAE, appeared to exacerbate PAE-related 2-week head circumference reductions, and elevated maternal ferritin, which we have shown to be associated with PAE, appeared to exacerbate PAE-related visual recognition memory deficits. In causal inference analyses, PAE-related elevations in maternal ferritin and hemoglobin:log(ferritin) appeared to statistically mediate 22.6–82.3% of PAE-related growth restriction. These findings support potential mechanistic roles of iron homeostasis alterations in fetal alcohol spectrum disorders (FASD).
Role of Inflammatory Factors in Mediating the Effect of Lipids on Nonalcoholic Fatty Liver Disease: A Two-Step, Multivariable Mendelian Randomization Study
Authors: Chen Junhong , Zhou Hao , Jin Hengwei , Liu Kai
Published: October 2022

Aims/hypothesis: 20–80% of Nonalcoholic Fatty Liver Disease (NAFLD) have been observed to have dyslipidemia. Nevertheless, the probable mechanism of dyslipidemia’s effect on NAFLD remains unclear. Mendelian randomization (MR) was utilized to investigate the relationship between lipids, inflammatory factors, and NAFLD; and also, to determine the proportion mediated by interleukin-17(IL-17) and interleukin-1β(IL-1β) for the effect between lipids and NAFLD. Methods: Summary statistics of traits were obtained from the latest and largest genome-wide association study (GWAS). The UK Biobank provided a summary of lipid statistics, which comprised up to 500,000 participants of European descent. And NAFLD GWAS summary statistics were obtained from the FinnGen Biobank which included a total sample size of 218,792 participants of European ancestry. In order to gain an overall picture of how lipids affect NAFLD, MR with two samples was carried out. Multivariable MR determined lipids direct effects on NAFLD after adjusting for inflammatory factors, namely IL-1β, interleukin-6(IL-6), interleukin-16(IL-16), IL-17, and interleukin-18(IL-18); those lipids comprise HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein A1 (ApoA1), and apolipoprotein B (ApoB). For the purpose of determining the MR impact, an inverse variance weighted (IVW) meta-analysis of each Wald Ratio was carried out, while other methods were also performed for sensitivity analysis. Results: We discovered a positive association between genetically predicted TGs levels and a 45.5% elevated risk of NAFLD, while genetically predicted IL-1β [(IVW: OR 1.315 (1.060–1.630), p = 0.012) and IL-17 [(IVW: OR 1.468 (1.035–2.082), p = 0.032] were positively associated with 31.5% and 46.8% increased risk of NAFLD, respectively. Moreover, TG was positively associated with 10.5% increased risk of IL-1β and 17.3% increased risk of IL-17. The proportion mediated by IL-17 and IL-1β respectively and both was 2.6%, 3.1%, 14.1%. Conclusion: Genetically predicted TGs, IL-1β, and IL-17 were positively associated with increased risk of NAFLD, with evidence that IL-1β and IL-17 mediated TGs effect upon NAFLD risk. It indicated that early diet management, weight management, lipid-lowering and anti-inflammatory treatment should be carried out for patients with hyperlipidemia to prevent the NAFLD.
Consumer Awareness of the Degree of Industrial Food Processing and the Association with Healthiness—A Pilot Study
Authors: Bolhuis Dieuwerke , Mosca Ana Carolina , Pellegrini Nicoletta
Published: October 2022

Consumption of ultraprocessed foods (UPFs) has been associated with lower diet quality, obesity, and adverse health effects. Not much is known about how consumers evaluate the degree of processing of a food product and how they relate this to healthiness. An online questionnaire was completed by a total of 277 Dutch, 204 Italian, and 181 Brazilian consumers. Consumers were aged 18–65 year, mean 38 ± 13 year, 31% were males, and 71% were highly educated. Pictures of several common food products were evaluated on the degree of industrial processing and healthiness. Thirteen food categories were included, each including one minimally processed food (MPF), one High NS_UPF (Nutri-Score A or B), and one Low NS_UPF (Nutri-Score D or E). Lastly, knowledge and attitude about UPFs were assessed. Ultraprocessing was perceived as unhealthy by the majority of consumers (Dutch, Italian: 55%; Brazilian: 75%) and contributed to weight gain according to: 38% Dutch, 51% Italian, and 70% Brazilian consumers. Low NS_UPFs were correctly rated toward “processed” and “not healthy” in all countries. High NS_UPF were rated as processed but showed large variations in healthiness scores. In conclusion, consumers rated UPFs relatively low in healthiness compared with MPFs with similar Nutri-Scores within the same food category. These preliminary findings suggest that consumers incorporate, to some extent, the degree of industrial processing while assessing the healthiness of food products.
Association of Objectively Measured Physical Activity with Physical Function in Patients with Sarcopenia during Hospitalized Rehabilitation
Authors: Ohtsubo Takuro , Nozoe Masafumi , Kanai Masashi , Ueno Katsuhiro , Nakayama Mai
Published: October 2022

This study aimed to investigate the association between objectively measured physical activity and functional improvement in hospitalized patients with sarcopenia. In this retrospective cohort study, physical activity (light-intensity physical activity [LIPA]; moderate-to-physical activity [MVPA]) was measured using a triaxial accelerometer in patients with sarcopenia undergoing rehabilitation on hospital admission. The primary outcome was physical function measured with the SPPB and activity of daily living (ADL) measured with the functional independence measure scores for motor function (FIM-M) at hospital discharge. Multiple regression analysis was per-formed to investigate the relationship between the objectively measured physical activity and functional outcomes. A total of 182 patients with sarcopenia (aged 81; interquartile range (IQR) 13 years) were included in this study. In the multiple regression analysis, LIPA was associated with the SPPB score at discharge (β = 0.180, p = 0.015) but not with FIM-M at discharge. MVPA was not associated with SPPB or FIM-M scores at discharge. In conclusion, LIPA on admission is independently associated with physical function, but not ADL, in patients with sarcopenia undergoing hospitalized rehabilitation.
Attitudes to Three Weight Maintenance Strategies: A Qualitative Study
Authors: Bird Frances , Searle Aidan , Rogers Peter J. , England Clare
Published: October 2022

Weight loss maintenance can be difficult and ultimately unsuccessful, due to psychological, behavioural, social, and physiological influences. The present study investigated three strategies with the potential to improve weight maintenance success: daily weighing, missing an occasional meal, habitually changing high energy foods. The principal aim was to gain an understanding of attitudes to these strategies in participants who had recent experience of weight loss attempts, with or without maintenance. This was a qualitative study involving semi-structured interviews, with 20 participants aged 18–67 (twelve females), analysed using thematic analysis. Most participants disliked daily weighing and missing an occasional meal for long-term maintenance and were concerned about potential negative effects on mental health. All participants had experience of habitual changes to high energy foods and regarded this strategy as obvious and straightforward. Replacement of high energy foods was favoured over elimination. Participants preferred strategies that felt flexible, “normal” and intuitive and disliked those that were thought to have a negative impact on mental health. Further investigation is needed on whether concerns regarding mental health are well founded and, if not, how the strategies can be made more acceptable and useful.
Comparing Even with Skewed Dietary Protein Distribution Shows No Difference in Muscle Protein Synthesis or Amino Acid Utilization in Healthy Older Individuals: A Randomized Controlled Trial
Authors: Justesen Thomas Ehlig Hjermind , Jespersen Simon Elmer , Tagmose Thomsen Thomas , Holm Lars , van Hall Gerrit , Agergaard Jakob
Published: October 2022

Sarcopenia is a multifactorial disease that limits autonomy for the growing elderly population. An optimal amount of dietary protein has shown to be important to maintain muscle mass during aging. Yet, the optimal distribution of that dietary protein has not been fully clarified. The aim of the present study was to examine whether an even, compared to a skewed, distribution of daily dietary protein leads to higher muscle protein synthesis and amino acid utilization. Twelve healthy males and twelve healthy females aged between 65 and 80 years were block randomized to either an even (EVEN, n = 12) or skewed (SKEWED, n = 12) dietary protein distribution for three daily main meals. Seven days of habituation were followed by three trial days, which were initiated by oral intake of deuterium oxide (D2O). The dietary protein throughout all trial meals was intrinsically labelled with 2H5-phenylalanine. Blood samples were drawn daily, and muscle biopsies were taken before and at the end of the trial to measure muscle protein synthesis (FSR) and muscle protein incorporation of the dietary-protein-derived tracer. Muscle protein FSR was no different between the two groups (EVEN 2.16 ± 0.13%/day and SKEWED 2.23 ± 0.09%/day, p = 0.647), and the muscle protein incorporation of the intrinsically labeled 2H5-phenylalanine tracer was not different between the two groups (EVEN 0.0049 ± 0.0004 MPE% and SKEWED 0.0054 ± 0.0003 MPE%, p = 0.306). In conclusion, the daily distribution pattern of the dietary protein did not affect muscle protein synthesis or the utilization of dietary protein.
Free Sugar Intake and Periodontal Diseases: A Systematic Review
Authors: Kusama Taro , Nakazawa Noriko , Takeuchi Kenji , Kiuchi Sakura , Osaka Ken
Published: October 2022

High free sugar intake is associated with an increased risk of various non-communicable diseases. We aimed to systematically review articles investigating the association between free sugar intake and periodontal diseases. This systematic review was conducted according to PRISMA guidelines and was registered in the PROSPERO database (CRD42022337828). We obtained articles from PubMed, Web of Science, and Scopus in April 2022. The study selection was performed according to predefined eligibility criteria based on the following PECOS: (P) general population, (E/C) free-sugar-containing food/beverage intake, (O) clinically measured periodontal diseases, and (S) observational study and clinical trial. Of the 839 screened records, 13 studies were included in the review. Most studies (n = 12) had a cross-sectional design. The age groups in the included studies were children/adolescents (n = 5) and adults (n = 8). Among the included studies, 11 reported a significant association between the frequent intake of free-sugar-containing food or beverages and a higher prevalence or incidence of periodontal diseases. The quality of most of the included studies was scored “fair” based on the Newcastle–Ottawa Quality Assessment Scale. Although the majority of the included studies reported a significant positive association between high free sugar intake and periodontal diseases, the evidence is considered to be limited due to the study designs.
Child and Adult Care Food Program Participation Benefits, Barriers and Facilitators for Independent Child Care Centers in California
Authors: Lee Danielle L. , Homel Vitale Elyse , Marshall Samantha Kay-Daleiden , Hecht Christina , Beck Lindsay T. , Ritchie Lorrene D.
Published: October 2022

The Child and Adult Care Food Program (CACFP) provides reimbursements for nutritious foods for children with low-income at participating child care sites in the United States. The CACFP is associated with improved child diet quality, health outcomes, and food security. However CACFP participation rates are declining. Independent child care centers make up a substantial portion of CACFP sites, yet little is known about their barriers to participation. Researcher-led focus groups and interviews were conducted in 2021–2022 with 16 CACFP-participating independent centers and 5 CACFP sponsors across California CACFP administrative regions to identify participation benefits, barriers, and facilitators. Transcripts were coded for themes using the grounded theory method. CACFP benefits include reimbursement for food, supporting communities with low incomes, and healthy food guidelines. Barriers include paperwork, administrative reviews, communication, inadequate reimbursement, staffing, nutrition standards, training needs, eligibility determination, technological challenges, and COVID-19-related staffing and supply-chain issues. Facilitators included improved communication, additional and improved training, nutrition standards and administrative review support, online forms, reduced and streamlined paperwork. Sponsored centers cited fewer barriers than un-sponsored centers, suggesting sponsors facilitate independent centers’ CACFP participation. CACFP participation barriers should be reduced to better support centers and improve nutrition and food security for families with low-income.
Dietary Management Tools Improve the Dietary Skills of Patients with T2DM in Communities
Authors: Chen Xueying , Min Hewei , Sun Xinying
Published: October 2022

Dietary management is of paramount importance in the prevention and control of type 2 diabetes mellitus (T2DM). This one-year cluster-randomized controlled trial aims to evaluate the effect of dietary management tools on the dietary skills of patients with T2DM. Twenty-two communities were randomly assigned to an intervention group and a control group, and participants in the intervention group received a food guiding booklet (G) and a dinner set (D). The frequency of dietary management tools usage was collected at baseline and every three months, and different use patterns were identified by a group-based trajectory model. A self-compiled diabetic dietary skills scale and blood glucose were collected at baseline, 3, and 12 months, and a using generalized linear mixed model (GLMM) to explore the influence factors of dietary skills and blood glucose. The finding revealed four dietary tool-usage patterns among the participants: Insist using G/D, Give up gradually G/D, Give up after use G, and Never use G/D. GLMM indicated that dietary skills were higher over time (p < 0.05), and in participants using the guiding booklet (p < 0.001) or dinner set (p < 0.001), or with higher education (p < 0.001). Additionally, blood glucose were lower among participants with higher dietary skills (p = 0.003), higher educational level (p = 0.046), and a 3000–5000 monthly income (p = 0.026). These findings support using food management tools like the guiding booklet and dinner set as a useful strategy in primary health care centers for individuals with T2DM to increase their dietary skills and blood glucose control.
Graph Theory-Based Electroencephalographic Connectivity via Phase-Locking Value and Its Association with Ketogenic Diet Responsiveness in Patients with Focal Onset Seizures
Authors: Hsieh Tzu-Yun , Hung Pi-Lien , Su Ting-Yu , Peng Syu-Jyun
Published: October 2022

Ketogenic diets (KDs) are a promising alternative therapy for pediatric refractory epilepsy. Several predictors of KD responsiveness have been identified, including biochemical parameters, seizure types, and electroencephalography (EEG) examinations. We hypothesized that graph theory-based EEG functional connectivity could explain KD responses in patients presenting focal onset seizure (FOS). A total of 17 patients aged 0–30 years old with focal onset seizures (FOS) were recruited as a study group between January 2015 and July 2021. Twenty age-matched children presenting headache with no intracranial complications nor other medical issues were enrolled as a control group. Data were obtained at baseline and at 12 months after initiating KD therapy (KDT) using the child behavior checklist (CBCL) and brain functional connectivity parameters based on phase-locking value from 19 scalp EEG signals, including nodal strength, global efficiency, clustering coefficient, and betweenness centrality. Compared with age-matched controls, patients presenting FOS with right or bilateral EEG lateralization presented higher baseline functional connectivity, including parameters such as global efficiency, mean cluster coefficient and mean nodal strength in the delta and beta frequency bands. In patients presenting FOS with right or bilateral EEG lateralization, the global efficiency of functional connectivity parameters in the delta and theta frequency bands was significantly lower at 12 months after KDT treatment than before KDT. Those patients also presented a significantly lower mean clustering coefficient and mean nodal strength in the theta frequency band at 12 months after KDT treatment. Changes in brain functional connectivity were positively correlated with social problems, attention, and behavioral scores based on CBCL assessments completed by parents. This study provides evidence that KDT might be beneficial in the treatment of patients with FOS. Graph theoretic analysis revealed that the observed effects were related to decreased functional connectivity, particularly in terms of global efficiency. Our findings related to brain connectivity revealed lateralization to the right (non-dominant) hemisphere; however, we were unable to define the underlying mechanism. Our data revealed that in addition to altered brain connectivity, KDT improved the patient’s behavior and emotional state.
Infant Feeding Practices, Nutrition, and Associated Health Factors during the First Six Months of Life among Syrian Refugees in Greater Beirut, Lebanon: A Mixed Methods Study
Authors: Abou-Rizk Joana , Jeremias Theresa , Nasreddine Lara , Jomaa Lamis , Hwalla Nahla , Frank Jan , Scherbaum Veronika
Published: October 2022

The objective was to describe infant feeding practices, nutrition and related health aspects of infants under six months among Syrian refugees in Greater Beirut, Lebanon. A cross-sectional study was conducted among Syrian refugee mothers with infants under six months in July–October 2018 (N = 114). Additionally, eleven focus group discussions were conducted to explore supportive factors and barriers associated with early breastfeeding practices. The prevalence of pre-lacteal feeding was high (62.5%), whereas early initiation of breastfeeding was low (31%), and exclusive breastfeeding very low (24.6%). One-fifth of the infants were anemic (20.5%) and 9.6% were wasted. A significantly higher proportion of non-exclusively breastfed infants had a fever and took medicines than those who were exclusively breastfed. Supporting factors of adequate infant feeding practices comprised knowledge on maternal nutrition and exclusive breastfeeding, along with receiving support from healthcare professionals and family members. Identified barriers included preterm delivery, pre-lacteal feeding, an at-risk waist circumference and moderate to severe depression among mothers, bottle feeding, early introduction of food, maternal health reasons, breastmilk substitutes’ distribution, and misinformation offered by mothers-in-law. To address sub-optimal feeding practices documented among Syrian refugees, awareness on proper breastfeeding practices, maternal nutrition, and psychosocial support should be provided to mothers and family members alike.
The Effect of Walnut Intake on Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Alshahrani Saeed Mastour , Mashat Reham M. , Almutairi Diaa , Mathkour Alaa , Alqahtani Sahar Saad , Alasmari Amirah , Alzahrani Abdullah Hassan , Ayed Reem , Asiri Mohammed Yahya , Elsherif Alsanussi , Alsabaani Abdullah
Published: October 2022

Cardiovascular diseases (CVD) are the leading causes of death worldwide. Dyslipidemia is a cardiometabolic risk factor of CVD, yet it can be modifiable. Walnuts have been suggested as a dietary intervention to improve the lipid profile. Therefore, we reviewed the literature to assess the evidence linking walnut intake to the improvement of blood lipids, including total cholesterol (TC), low-density lipoprotein (LDL-C) cholesterol, high-density lipoprotein (HDL-C) cholesterol, and triglycerides (TG). PubMed and Embase databases were searched from 2010 up to March 2022. We limited our search to randomized controlled trials conducted on humans and published in English during the specified period. Cochrane’s risk of bias tool for interventional studies was used. A random-effects model was used for the meta-analysis, and weighted mean differences were obtained (WMD) Thirteen trials from the U.S., Europe, and Asia were included. Walnut intake was associated with significant reductions in TC (WMD: −8.58 mg/dL), LDL-C (WMD: −5.68 mg/dL), and TG (WMD: −10.94 mg/dL). Walnut consumption was not associated with HDL-C. Subgroup analysis showed that overweight/obese and those with comorbidities had more lipid improvement. A longer trial duration did result in further improvements. However, our results may be prone to bias due to extraneous confounding factors. Additionally, levels of heterogeneity were considerable for some outcomes of interest. Results from this meta-analysis provide evidence for the health benefits of walnuts on blood lipids. Walnuts possibly reduce the risk of CVD; thus, they can be successfully added to a dietary pattern to enhance health benefits.
Effect of Acute Dietary Nitrate Supplementation on the Venous Vascular Response to Static Exercise in Healthy Young Adults
Authors: Oue Anna , Iimura Yasuhiro , Shinagawa Akiho , Miyakoshi Yuichi , Ota Masako
Published: October 2022

The purpose of this study was to test the hypothesis that acute intake of inorganic nitrate (NO3−) via supplementation would attenuate the venoconstriction and pressor response to exercise. Sixteen healthy young adults were assigned in a randomized crossover design to receive beetroot juice (BRJ) or an NO3−-depleted control beverage (prune juice: CON). Two hours after consuming the allocated beverage, participants rested in the supine position. Following the baseline period of 4 min, static handgrip exercise of the left hand was performed at 30% of the maximal voluntary contraction for 2 min. Mean arterial pressure (MAP) and heart rate (HR) were measured. Changes in venous volume in the right forearm and right calf were also measured using venous occlusion plethysmography while cuffs on the upper arm and thigh were inflated constantly to 30–40 mmHg. The plasma NO3− concentration was elevated with BRJ intake (p < 0.05). Exercise increased MAP and HR and decreased venous volume in the forearm and calf, but there were no differences between CON and BRJ. Thus, these findings suggest that acute BRJ intake does not alter the sympathetic venoconstriction in the non-exercising limbs and MAP response to exercise in healthy young adults, despite the enhanced activity of nitric oxide.
Digital Biomarkers for Personalized Nutrition: Predicting Meal Moments and Interstitial Glucose with Non-Invasive, Wearable Technologies
Authors: van den Brink Willem J. , van den Broek Tim J. , Palmisano Salvator , Wopereis Suzan , de Hoogh Iris M.
Published: October 2022

Digital health technologies may support the management and prevention of disease through personalized lifestyle interventions. Wearables and smartphones are increasingly used to continuously monitor health and disease in everyday life, targeting health maintenance. Here, we aim to demonstrate the potential of wearables and smartphones to (1) detect eating moments and (2) predict and explain individual glucose levels in healthy individuals, ultimately supporting health self-management. Twenty-four individuals collected continuous data from interstitial glucose monitoring, food logging, activity, and sleep tracking over 14 days. We demonstrated the use of continuous glucose monitoring and activity tracking in detecting eating moments with a prediction model showing an accuracy of 92.3% (87.2–96%) and 76.8% (74.3–81.2%) in the training and test datasets, respectively. Additionally, we showed the prediction of glucose peaks from food logging, activity tracking, and sleep monitoring with an overall mean absolute error of 0.32 (+/−0.04) mmol/L for the training data and 0.62 (+/−0.15) mmol/L for the test data. With Shapley additive explanations, the personal lifestyle elements important for predicting individual glucose peaks were identified, providing a basis for personalized lifestyle advice. Pending further validation of these digital biomarkers, they show promise in supporting the prevention and management of type 2 diabetes through personalized lifestyle recommendations.
Impact of Indian Ocean Dipole Events on Phytoplankton Size Classes Distribution in the Arabian Sea
Authors: Shunmugapandi Rebekah , Gedam Shirishkumar , Inamdar Arun B.
Published: October 2022

Changes in the environmental condition associated with climatic events could potentially influence the PSC dynamics of the regional marine ecosystem. The Indian Ocean dipole (IOD) is one of the critical ocean–atmosphere interactions that affects the climate of the Arabian Sea, and it could be a potential factor influencing the regional PSC distribution. However, the relationship between PSC and IOD remains unclear and less explored. In this study, using the in-situ database acquired from the Arabian Sea, we reparametrized the three−component abundance−based phytoplankton size class model and applied it to reconstructed satellite−derived chlorophyll−a concentration to extract the fractional contribution of phytoplankton size classes to chlorophyll−a concentration. Further, we investigated the influence of IOD on the changes in the biological–physical properties in the Arabian Sea. The results showed that the biological–physical processes in the Arabian Sea are interlinked and the changes in the IOD mode control the physical variables like sea surface temperature (SST), sea surface height (SSH), and mixed layer depth (MLD), which influence the specific PSC abundance. Unprecedented changes in the PSC distribution and physical properties were observed during the extreme positive and negative IOD events, which clearly indicated the potential role of IOD in altering the PSC distribution in the Arabian Sea. This study highlights the impact of extreme climate events on PSC distribution and the need for a better understanding of the associated physical–biological–climate interactions.
Electromagnetic Response in an Expanding Quark–Gluon Plasma
Authors: Shovkovy Igor A.
Published: October 2022

The validity of conventional Ohm’s law is tested in the context of a rapidly evolving quark–gluon plasma produced in heavy-ion collisions. Here, we discuss the electromagnetic response using an analytical solution in kinetic theory. As conjectured previously, after switching on an electric field in a nonexpanding plasma, the time-dependent current is given by J(t)=(1−e−t/τ0)σ0E, where τ0 is the transport relaxation time and σ0 is the steady-state electrical conductivity. Such an incomplete electromagnetic response reduces the efficiency of the magnetic flux trapping in the quark–gluon plasma, and may prevent the observation of the chiral magnetic effect. Here, we extend the study to the case of a rapidly expanding plasma. We find that the decreasing temperature and the increasing transport relaxation time have opposite effects on the electromagnetic response. While the former suppresses the time-dependent conductivity, the latter enhances it.
Molecular and Serological Diagnostic Approach to Define the Microbiological Origin of Blood Culture-Negative Infective Endocarditis
Authors: El-Ashry Amira H. , Saad Khaled , Obiedallah Ahmed A. , Elhoufey Amira , Dailah Hamad Ghaleb , Hussein Mohammed Salah A.
Published: October 2022

Blood culture-negative infective endocarditis (BCNIE) poses a significant challenge in determining the best antibiotic regimen for this life-threatening infection, which should be treated with as specific and effective a regimen as feasible. The goal of this study was to determine the prevalence of BCNIE among definite infective endocarditis (IE) cases and to study the impact of a molecular and serological diagnostic approach in defining the microbiological origin of BCNIE. This study included 94 definite IE cases. Serum and blood samples from BCNIE patients were tested using serological, broad-range PCR, and sequencing assays. Valve tissue sections obtained from 42 operated patients were subjected to culture and molecular studies. BCNIE accounted for 63 (67%) of the cases. Of these cases, blood PCR followed by sequencing could diagnose 11 cases. Zoonotic infective endocarditis was detected in 7 (11%) patients by serology and PCR (four Brucella, two Bartonella, and one Coxiella). Sequencing of valve PCR bands revealed 30 positive cases. Therefore, the percentage of BCNIE with unidentified etiology was reduced from 67% to 27.7% through a combination of all diagnostic procedures utilized in our study. Blood and valve PCR and sequencing assays are valuable techniques for the etiological diagnosis of BCNIE, especially in cases with previous antibiotic therapy. However, these tests should be used as part of a larger diagnostic strategy that includes serology, microscopy, and valve culture. The use of an automated blood culture system, and proper blood culture collection before ordering antibiotics, will guide IE etiological diagnosis.
Paeonol Protects against Methotrexate Hepatotoxicity by Repressing Oxidative Stress, Inflammation, and Apoptosis—The Role of Drug Efflux Transporters
Authors: Morsy Mohamed A. , Abdel-Latif Rania , Hafez Sara Mohamed Naguib Abdel , Kandeel Mahmoud , Abdel-Gaber Seham A.
Published: October 2022

Methotrexate (MTX) is an effective chemotherapeutic agent against a wide range of tumors and autoimmune diseases; however, hepatotoxicity limits its clinical use. Oxidative stress and inflammation have been implicated in the pathogenesis of MTX-induced hepatotoxicity. Paeonol is a natural phenolic compound reported for its antioxidant and anti-inflammatory properties. The current study aimed to investigate the protective effect of paeonol against MTX-induced hepatotoxicity in rats and various mechanisms that underlie this postulated effect. Paeonol was administered orally in a dose of 100 mg/kg, alone or along with MTX, for 10 days. Hepatotoxicity was induced via a single intraperitoneal dose of MTX (20 mg/kg) on day 5 of the experiment. Concomitant administration of paeonol with MTX significantly ameliorated distorted hepatic function and histological structure, restored hepatic oxidative stress parameters (MDA, NO, and SOD), and combated inflammatory response (iNOS and TNF-α). Additionally, paeonol enhanced cell proliferation and survival, evidenced by upregulating the proliferating cell nuclear antigen (PCNA) and suppressing apoptosis and the disposition of collagen fibers in rat livers treated with MTX. Importantly, paeonol upregulated the drug efflux transporters, namely P-glycoprotein (P-gp) and the multidrug resistance-associated protein 2 (Mrp-2) in MTX-treated rats. In conclusion, paeonol offered a potent protective effect against MTX-induced hepatotoxicity through suppressing oxidative stress, inflammation, fibrosis, and apoptosis pathways, along with P-gp and Mrp-2 upregulation.
In Vitro and In Vivo Evaluation of the Effectiveness and Safety of Amygdalin as a Cancer Therapy
Authors: El-Ela Fatma I. Abo , Gamal Amr , Elbanna Hossny Awad , ElBanna Ahmed H. , Salem Heba F. , Tulbah Alaa S.
Published: October 2022

Cancer is one of the most important causes of death worldwide. Several studies have shown the efficacy of apricot kernel seed as a cancer therapy due to the presence of amygdalin. These studies have demonstrated amygdalin’s cytotoxicity, antioxidant activity, and apoptosis in vitro using human cancer cell lines. However, no studies have demonstrated their cancer activity in vivo. The aim of this study is to develop an amygdalin-loaded niosomes (ALN) gel formulation as a drug delivery system in order to investigate the selectivity, efficacy, and toxicity of amygdalin as a cancer therapy in vivo using the 7,12-dimethylbenz (a) anthracene (DMBA) carcinoma rat model. Based on pre-formulation studies, the ALN formulation composed of Tween 60: cholesterol: dihexadecyl phosphate in a molar ratio of 1:2:0.1 was chosen as an optimum formulation because it has a percent of EE of 66.52% with a particle size of 269.3 nm and a reflux of 3.54 µg.cm−2.h−1. The ALN gel formulation was integrated into carbopol gel to be evaluated in vivo. Compared to DMBA control, treatment with ALN gel showed a reduction in the carcinoma volume and in the hyperplasia of the epidermis with no signs of edema. In conclusion, the ALN gel formulation could be an efficient cancer therapy.
Evaluation of Formalin-Fixed and FFPE Tissues for Spatially Resolved Metabolomics and Drug Distribution Studies
Authors: Dannhorn Andreas , Swales John G. , Hamm Gregory , Strittmatter Nicole , Kudo Hiromi , Maglennon Gareth , Goodwin Richard J. A. , Takats Zoltan
Published: October 2022

Fixation of samples is broadly used prior to the histological evaluation of tissue samples. Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry imaging (MSI) based proteomics, glycomics and tumor classification studies, to date comprehensive evaluation of fixation-related effects for spatially resolved metabolomics and drug disposition studies is still missing. In this study we used matrix assisted laser desorption/ionization (MALDI) and desorption electrospray ionization (DESI) MSI to investigate the effect of formalin-fixation and formalin-fixation combined with paraffin embedding on the detectable metabolome including xenobiotics. Formalin fixation was found to cause significant washout of polar molecular species, including inorganic salts, amino acids, organic acids and carnitine species, oxidation of endogenous lipids and formation of reaction products between lipids and fixative ingredients. The slow fixation kinetics under ambient conditions resulted in increased lipid hydrolysis in the tissue core, correlating with the time-dependent progression of the fixation. Paraffin embedding resulted in subsequent partial removal of structural lipids resulting in the distortion of the elucidated biodistributions.