bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-Cell Analysis in Blood Reveals Distinct Immune Cell Profiles in Gouty Arthritis
Authors: Wang Maojie , Chen Wenying , Zhang Xiaolin , Mei Liyan , Wu Xiaodong , Chen Xiumin , Yang Zhihua , Gao Kaixin , Huang Huanjie , Huang Runyue
Published: January 2023

Gout is a chronic disease caused by monosodium urate crystal deposition. Previous studies have focused on the resident macrophage, infiltrating monocyte, and neutrophil responses to monosodium urate crystal, yet the mechanisms of the potential involvement of other immune cells remain largely unknown. In this study, we enrolled seven gout patients and five age-matched healthy individuals and applied single-cell mass cytometry to study the distribution of immune cell subsets in peripheral blood. To our knowledge, our study reveals the immune cell profiles of gout at different stages for the first time. We identified many immune cell subsets that are dysregulated in gout and promote gouty inflammation, especially those highly expressing CCR4 and OX40 (TNFR superfamily member 4), including CCR4+OX40+ monocytes, CCR4+OX40+CD56high NK cells, CCR4+OX40+CD4+ NK T cells, and CCR4+CD38+CD4+ naïve T cells. Notably, the plasma levels of CCL17 and CCL22, measured by ELISA, increased in the acute phase of gout and declined in the interval. We also found a clue that Th2-type immune responses may participate in gout pathology. Moreover, the subset of granzyme B+ (GZMB+) CD38+ NK cells is positively correlated with serum urea acid level, and another two γδT subsets, GZMB+CD161+ γδT cells and GZMB+CCR5+ γδT cells, are negatively correlated with erythrocyte sedimentation rate. In sum, gouty arthritis is not a disease simply mediated by macrophages; multiple types of immune cell may be involved in the pathogenesis of the disease. Future research needs to shift attention to other immune cell subsets, such as NK cells and T cells, which will facilitate the identification of novel therapeutic targets.
The COVID-19 wave was already here: High seroprevalence of SARS-CoV-2 antibodies among staff and students in a Cameroon University
Authors: Wondeu Andrillene Laure Deutou , Talom Beatrice Metchum , Linardos Giulia , Ngoumo Barnes Tanetsop , Bello Aïchatou , Soufo Aurele Marc Ndassi , Momo Aimé Cesaire , Doll Christian , Tamuedjoun Alaric Talom , Kiuate Jules-Roger , Cappelli Giulia , Russo Cristina , Perno Carlo Federico , Tchidjou Hyppolite K. , Scaramella Lucia , Galgani Andrea
Published: January 2023

Background: Seroprevalence studies, to estimate the proportion of people that has been infected by SARS-CoV-2 are importance in African countries, where incidence is among the lowest in the world.Objective: This study aimed at evaluating the exposure to SARS-CoV-2 within a university setting of Cameroon.Methods: A cross-sectional study performed in December 2020 - December 2021, among students and staffs of the Evangelical University of Cameroon. COVID-19 antigen rapid detection test (RDT) was performed using Standard Q Biosensor, and one year after SARS-CoV-2 antibody-test was performed within the same population using RDT and chemiluminescence immunoassay (CLIA).Results: 106 participants were enrolled (80% students), female sex was the most represented. Positivity to SARS-CoV-2 was 0.0% based on antigen RDTs. The seroprevalence of SARSCoV- 2 antibodies was estimated at 73.6% (95% CI. 64.5-81.0) for IgG and 1.9% (95% CI. 0.2-6.8) for IgM/IgG with RDTs, and 91.9% (95% CI. 84.7-96.4) for anti-nucleocapsid with CLIA. 95.3% (101) reported having developed at least one of the known COVID-19 symptoms (cough and headache being the most common). 90.3% (28) of people who experienced at least one of these symptoms developed IgG antibodies. 40.6% (43) of participants took natural herbs, whereas 55.7% (59) took conventional drugs. The most used herb was Zingiber officinale, while the most used drugs were antibiotics.Conclusion: In this Cameroonian University community, SARS-CoV-2 seroprevalence is high, with a greater detection using advanced serological assays. This indicates a wide viral exposure, and the need to adequate control measures especially for those experiencing any related COVID-19 symptoms.
Cardiovascular Outcomes according to Comorbidities and Low-Density Lipoprotein Cholesterol in Korean People with Type 2 Diabetes Mellitus
Authors: Moon Min Kyong , Noh Junghyun , Rhee Eun-Jung , Park Sang Hyun , Kim Hyeon Chang , Kim Byung Jin , Kim Hae Jin , Choi Seonghoon , Na Jin Oh , Hyun Young Youl , Kim Bum Joon , Han Kyung-Do , Jeong In-Kyung ,   on Behalf of the Committee of Practice Guideline of Korean Lipid and Atheroscelerosis
Published: January 2023

Background: There are no clear data to support the cardiovascular (CV) risk categories and low-density lipoprotein cholesterol (LDL-C) treatment goals in Korean people with type 2 diabetes mellitus (T2DM). We evaluated the incidence of cardiovascular disease (CVD) according to comorbidities and suggested LDL-C treatment goals in Korean people with T2DM in nationwide cohort data.Methods: Using the Korean National Health Insurance Service database, 248,002 people aged 30 to 90 years with T2DM who underwent routine health check-ups during 2009 were included. Subjects with previous CVD were excluded from the study. The primary outcome was incident CVD, defined as a composite of myocardial infarction and ischemic stroke during the follow-up period from 2009 to 2018.Results: The mean age of the study participants was 59.6±10.9 years, and median follow-up period was 9.3 years. CVD incidence increased in the order of DM duration of 5 years or more (12.04/1,000 person-years), hypertension (HT) (12.27/1,000 personyears), three or more CV risk factors (14.10/1,000 person-years), and chronic kidney disease (18.28/1,000 person-years). The risk of incident CVD increased linearly from an LDL-C level of ≥70 mg/dL in most patients with T2DM. In T2DM patients without HT or with a DM duration of less than 5 years, the CVD incidence increased from LDL-C level of ≥100 mg/dL.Conclusion: For primary prevention of CVD in Korean adults with T2DM, it can be helpful to lower LDL-C targets when there are chronic kidney disease, HT, a long duration of diabetes mellitus, or three or more CV risk factors.
Lipid Management in Korean People with Type 2 Diabetes Mellitus: Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis Consensus Statement
Authors: Yang Ye Seul , Kim Hack-Lyoung , Kim Sang-Hyun , Moon Min Kyong ,   on Behalf of Committee of Clinical Practice Guideline,   Korean Diabetes Association and Clinical Practice Guideline Committee,   Korean Society of Lipid and Atherosclerosis
Published: January 2023

Dyslipidemia in patients with diabetes is an important treatment target as a modifiable risk factor for cardiovascular disease (CVD). Although the primary treatment goal for dyslipidemia is to control low-density lipoprotein cholesterol (LDL-C), achieving this goal remains suboptimal according to recent studies. It is important to set the target goal for LDL-C control based on an accurate risk assessment for CVD. Here, we summarize the latest evidence on lipid management in patients with diabetes and present a consensus of the Korean Diabetes Association and Korean Society of Lipid and Atherosclerosis on the treatment goals of LDL-C according to the duration of diabetes, presence of CVD, target organ damage, or major cardiovascular risk factors. In patients with type 2 diabetes mellitus (T2DM) and CVD, an LDL-C goal of <55 mg/dL and a reduction in LDL-C level by 50% or more from the baseline is recommended. For the primary prevention of CVD in patients with T2DM with a duration of diabetes ≥10 years, major cardiovascular risk factors, or target organ damage, an LDL-C goal of <70 mg/dL is recommended. In patients with T2DM with a duration of diabetes <10 years and no major cardiovascular risk factors, an LDL-C goal of <100 mg/dL is recommended.
A quantitative strong parabolic maximum principle and application to a taxis-type migration–consumption model involving signal-dependent degenerate diffusion
Authors: Michael Winkler
Published: January 2023

The taxis-type migration–consumption model accounting for signal-dependent motilities, as given by

u_{t} = \Delta (u\phi(v))

,

v_{t} = \Delta v-uv

, is considered for suitably smooth functions

\phi\colon[0,\infty)\to\R

which are such that

\phi>0

on

(0,\infty)

, but that in addition

\phi(0)=0

with

\phi'(0)>0

. In order to appropriately cope with the diffusion degeneracies thereby included, this study separately examines the Neumann problem for the linear equation

V_{t} = \Delta V + \nabla\cdot ( a(x,t)V) + b(x,t)V

and establishes a statement on how pointwise positive lower bounds for nonnegative solutions depend on the supremum and the mass of the initial data, and on integrability features of

a

and

b

. This is thereafter used as a key tool in the derivation of a result on global existence of solutions to the equation above, smooth and classical for positive times, under the mere assumption that the suitably regular initial data be nonnegative in both components. Apart from that, these solutions are seen to stabilize toward some equilibrium, and as a qualitative effect genuinely due to degeneracy in diffusion, a criterion on initial smallness of the second component is identified as sufficient for this limit state to be spatially nonconstant.
Stability of contact lines in fluids: 2D Navier–Stokes flow
Authors: Guo Yan , Tice Ian
Published: January 2023

In this paper we study the dynamics of an incompressible viscous fluid evolving in an open-top container in two dimensions. The fluid mechanics are dictated by the Navier–Stokes equations. The upper boundary of the fluid is free and evolves within the container. The fluid is acted upon by a uniform gravitational field, and capillary forces are accounted for along the free boundary. The triple-phase interfaces where the fluid, air above the vessel, and solid vessel wall come in contact are called contact points, and the angles formed at the contact point are called contact angles. The model that we consider integrates boundary conditions that allow for full motion of the contact points and angles. Equilibrium configurations consist of quiescent fluid within a domain whose upper boundary is given as the graph of a function minimizing a gravity-capillary energy functional, subject to a fixed mass constraint. The equilibrium contact angles can take on any values between 0 and

\pi

depending on the choice of capillary parameters. The main thrust of the paper is the development of a scheme of a priori estimates that show that solutions emanating from data sufficiently close to the equilibrium exist globally in time and decay to equilibrium at an exponential rate.
Комплекс Кузeна на дополнении к дивизору со строго нормальными пересечениями в локальной существенно гладкой схеме над полем
Authors: Druzhinin Andrei Eduardovich
Published: January 2023

Для всякой $\mathbb{A}^1$-инвариантной теории когомологий, удовлетворяющей вырезанию Нисневича на категории гладких схем над полем $k$, доказана точность комплекса Кузeна на дополнении $U-D$ к дивизору $D$ со строго нормальными пересечениями в локальной существенно гладкой схеме $U$, а также на схемах $(X-D)\times(\mathbb{A}^1_k-Z_0)\times…\times(\mathbb{A}^1_k-Z_l)$ для конечного множества замкнутых подмножеств $Z_0,…,Z_l$ в аффинной прямой над $k$.
Библиография: 32 названия.
Геометрические прогрессии в пространствах с расстоянием, приложения к неподвижным точкам и точкам совпадения отображений
Authors: Zhukovskiy Evgeny Semenovich
Published: January 2023

Рассматривается вопрос: каким свойством должно обладать пространство $X$ с обобщенным расстоянием $\rho_X$, чтобы для действующих в нем отображений были справедливы утверждения типа теорем Банаха и Надлера о неподвижной точке и утверждения типа теоремы Арутюнова о точках совпадения? Показано, что таким свойством является сходимость любой геометрической прогрессии со знаменателем, меньшим $1$, - последовательности $\{ x_i\}\subset X$, удовлетворяющей при некотором $\gamma < 1$ условию $\rho_X(x_{i+1},x_i)\leq \gamma \rho_X(x_i,x_{i-1})$, $ i=1,2,…$ . Приведены примеры пространств, обладающих и не обладающих данным свойством. В частности, показано, что требуемое свойство имеет место в полном $f$-квазиметрическом пространстве $X$, если в нем расстояние $\rho_X$ при некотором $\eta\in (0,1)$ удовлетворяет неравенству $\rho_X(x,z) \leq \rho_X(x,y)+(\rho_X(y,z))^\eta$, $x,y,z \in X$, т.е. когда функция $f\colon\mathbb{R}_+^{2} \to \mathbb{R}_+$ задана формулой $f(r_1,r_2)=r_1 + r_2^{\eta}$. А если $f(r_1,r_2)=\max\{ r_1^{\eta}, r_2^{\eta} \}$, где $\eta \in (0,2^{-1}]$, то для любого $\gamma > 0$ существует $f$-квазиметрическое пространство, содержащее геометрическую прогрессию со знаменателем $\gamma$, не являющуюся фундаментальной. Обсуждается справедливость в $f$-квазиметрических пространствах "правила $0$ или $1$", означающего, что либо любая геометрическая прогрессия со знаменателем, меньшим $1$, является фундаментальной, либо для произвольного $\gamma\in (0,1)$ существует геометрическая прогрессия со знаменателем $\gamma$, не являющаяся фундаментальной.
Библиография: 29 названий.
Zgodnji pesniški opus Vladimirja Kaučiča – Jeana Vodaina
Authors: Ferlež Urh
Published: January 2023

Članek predstavlja pesniški opus Vladimirja Kaučiča - Jeana Vodaina, ki je nastal med letoma 1945, ko je izdal svojo prvo pesniško zbirko Rose et noir in 1955, ko je sprejel službo pri pariški založbi Caractères, kjer je spoznaval vodilne francoske umetnike tistega časa (Tzara, Jakovski), kar je vplivalo na njegovo ustvarjanje in dojemanje umetnosti.
Kavčič se je rodil v takrat italijanski vasi Čiginj na Tolminskem. Družina se je preselila v Loreno, kjer je končal osnovno šolo in se začel preživljati kot fizični delavec. Povezal se je z delavskimi kulturnimi društvu in ustvarjal kot pesnik, slikar ter tipograf.
V članku analiziram njegove prve pesniške zbirke, in sicer Rose et noir (1945), Le toron noir (1947), A travers la lucarne (1949), L’arbre retrouvé (1951), Le jour se fera (1951), Pas de pitié pour les feuilles mortes (1951) in pesmi, ki so v tem času izšle v literarnih revijah.
Analiza je pokazala, da so bile v mladostnem obdobju Vodainove priljubljene mladostne teme narava, Lorena, tegobe delavskega razreda in življenja v sodobnem času nasploh. Kvaliteta te poezije je jezikovna spretnost in sopostavljanje delavske tematike z motivi iz narave in ljubeznijo, mestoma tudi ironijo. Vodainova zgodnja poezija je večinoma sicer shematična, deloma tudi repetitivna. Opazen je vpliv Paula Verlaine in Jacquesa Préverta. Zadnja analizirana zbirka Pas de pitié pour les feuilles mortes pomeni prelom v umetnikovem opusu, saj je v njej pesnik prvič pokazal svoj izvirni slog, ki v zbirkah zrelega obdobja pride bolj do izraza.
Meeting International Law Students’ Demands for Their Professional Foreign Language Learning
Authors: Samorodova Ekaterina , Bakaeva Sofia
Published: January 2023

Introduction. In today’s world, the profession of international lawyer has acquired a new status. This fact inspired the authors of the article to think about the need to analyse the foreign language competencies which international law students should obtain.
Aim. The objective of this article is to identify the best time to start the legal foreign language course at international law faculties; the competencies which law students acquire and want to acquire; and an assessment of the significance of the competencies acquired in the course of the legal foreign language training of law students.
Materials and methods. This article is a study based on an analysis of Russian and foreign scientists’ related works, and the results obtained during the surveys of 3rd- and 4th-year international law students at MGIMO studying a language. Both comparative and system analysis methods were used.
Results. This research reveals the students’ views on the best time to start learning the foreign language, the foreign language competencies acquired and wanted by the students, and their significance for their future careers.
Scientific novelty. Identification and analysis of the language competencies necessary for international lawyers’ professional activities, with aim of improving foreign language studies in this context, with the results for the first time based on students’ opinions.
Practical significance. The results of the present study can serve as a basis to develop new approaches and methods to improve the training of international law students and to create specialty foreign language training programs for non-linguistic students.
Introduction au français des affaires
Authors: Jarc Mojca
Published: January 2023

Univerzitetni prostor postaja vedno trdneje umeščen v tokove globalizacije, del katerih je tudi internacionalizacija visokošolskega prostora. Mednarodne študentske izmenjave kot pomemben dejavnik teh sprememb poleg obetov širjenja obzorij, področnih znanj in mnogih drugih dobrobiti med drugim prinašajo tudi potrebo po razvijanju sporazumevalne zmožnosti v tujem strokovnem jeziku. V tem kontekstu je bil univerzitetni učbenik Introduction au français des affaires avtoric Nadje Dobnik in Anne-Cécile Lamy-Joswiak zasnovan kot odgovor na potrebe študentov ekonomije, ki bi zaradi stikov s frankofonim študijskim okoljem želeli pridobiti ali osvežiti osnovna znanja francoskega jezika.
Semantična prozodija v specializiranih besedilih
Authors: Martič Matjaž
Published: January 2023

V članku s korpusnim pristopom obravnavamo semantično prozodijo izbranih najpogostejših besed s področja družbene odgovornosti v letnih poročilih angleških in slovenskih podjetij. Semantično prozodijo razumemo kot izražanje vrednotenjskega pomena, ki označuje tipično sopojavljanje besed oz. frazemov z leksikalnimi enotami, ki imajo pozitiven ali negativen pomen, poleg tega pa semantična prozodija izraža tudi odnos pisca/govorca in je tako sestavina pragmatičnega oz. funkcijskega pomena. Pri preučevanju semantične prozodije se osredinimo na koncept lokalnih prozodij, skladno s katerim lahko besede v določenih žanrih vzpostavijo lokalne semantične prozodije, ki se tipično pojavljajo zgolj v teh žanrih. Zgradili smo specializirani korpus letnih poročil angleških in slovenskih podjetij, ga ločili na angleški in slovenski podkorpus ter s korpusno analizo določili najpogostejše besede s področja družbene odgovornosti v posameznem podkorpusu. Na osnovi kolokacijskih in koligacijskih vzorcev, predvsem pa na osnovi preučevanja širšega kontekstualnega okolja smo identificirali vrednotenjski in pragmatični pomen izbranih besed. Ugotovili smo pretežno pozitiven vrednotenjski pomen tako pri angleških kot tudi slovenskih besedah ter precejšnje podobnosti pri pragmatičnemu pomenu angleških in slovenskih besed. Razloge za to smo iskali predvsem v sestavi korpusa, ki vključuje besedila, ki pripadajo žanru letnih poročil. V zaključku članka smo izpostavili pomen semantične prozodije v pedagoški praksi.
Blending as a Word-Formation Process
Authors: Grlj Tina
Published: January 2023

Although there are several ways of creating new words, the article investigates the morphological process that is referred to as lexical blending. Even if this minor word-formation process is increasingly popular, it is still not clearly defined and limited. This process is present in many languages, and is clear proof of how inventive a language can be. The first part of the article presents an examination of defining characteristics of blending and blend words according to different authors. The second part of the article is of a practical nature. Some of the key characteristics of blends discussed in the first part are tested on the basis of a corpus, which was compiled specifically for this purpose and contains 458 English and 396 French blends. Blends from each language are analysed separately in order to reveal any major discrepancies between English and French. The focal points of the analysis are the lexical categories of blends and of the source words entering each blend, the presence or absence of shortening of source words, the type of shortening of source words, the structural patterns of blends, the presence or absence of overlap between the source words, the type of overlap and the frequency of infixation. These parameters are corroborated by the statistical analysis of the corpus in order to reveal any prominent structural patterns in both languages. Additionally, some of these points of analysis are compared to the findings presented by Vincent Renner in “French and English lexical blends in contrast” (2018). His study includes 97 French and 374 English blends from two corresponding dictionaries in both languages, namely the Grand Robert de la langue française and the Shorter Oxford English Dictionary.
The European core–periphery divide: towards a new narrative
Authors: Casagrande Sara , Dallago Bruno
Published: January 2023

Economic theory has recently begun to consider the economic impact of narratives. Narrative economics can also be extended to the analysis of the economic–political effect of narratives in the context of the European core–periphery divide, which intensified after the European sovereign-debt crisis. The dominant narrative of the crisis has placed a lot of responsibility on southern member countries. With the outbreak of the COVID-19 emergency, this narrative has returned to influence European public debate. The authors state the importance of analysing the dominant narrative to understand its validity in explaining the sovereign-debt crisis, and the importance of overcoming it to face the health emergency effectively. Therefore, starting from some alternative explanations regarding the European crisis, a new alternative narrative is presented, which underlines the issues connected to the competitive attitude among member countries and the political disequilibrium that characterizes Economic and Monetary Union architecture.
Balance-sheet restructuring in Italy: an empirical analysis based on monetary circuit theory
Authors: Spanò Marcello
Published: January 2023

Based on 25 years (1995–2019) of fully integrated sectoral data, this study builds on monetary circuit theory to examine the Italian experience of growing private debt followed by a long recession with balance-sheet restructuring. It is argued that this process cannot be identified as a typical balance-sheet recession. After the global financial crisis of 2007–2008, Italian firms increased financial sources from economic activities by retaining earnings, lowering wages, and disinvesting. Their deleverage, however, rested largely on the overall financial wealth reallocation that occurred after 2012, which was induced by monetary and fiscal policy, creating the conditions for households to increase net saving and to channel cumulated wealth from government securities and money balances towards equities.
Modern money theory: some basics in response to Drumetz/Pfister
Authors: Leclaire Joëlle
Published: January 2023

This article examines the misconceptions about modern money theory (MMT) put forward by Drumetz/Pfister (2021). The author divides her critique into three categories. First, the Drumetz/Pfister article erroneously indicates that MMT focuses exclusively on the means-of-payment function of money, that it considers money as a pure asset, that it does not distinguish between inside and outside money, and that it does not distinguish between money and the monetary base. Second, Drumetz/Pfister (2021) falsely represent MMT as leaving monetary policy to law and as belittling the impact of quantitative easing. Drumetz/Pfister misunderstand what is meant by government debt being monetized. Third, their article puts forward the incorrect idea that increased government spending could lead to increased long-term interest rates, and that a zero interest rate could supposedly bring about macroeconomic instability and inflation.
Kadınlarda Algılanan Duygusal İstismar Düzeyi, İntihara Karşı Tutum ve İntihar Davranışlarının Değerlendirilmesi
Authors: BOZKURT Adile , İNEL MANAV Ayşe , ÜNAL Esra
Published: January 2023

Amaç: Araştırma kadınlarda algılanan duygusal istismar düzeyi, intihara karşı tutum ve intihar davranışlarının değerlendirilmesi amacıyla yapılmıştır.Yöntem: Kesitsel tipte olarak yapılan araştırma, 01.10.2020-01.01.2021 tarihlerinde Osmaniye Devlet Hastanesi Kadın Hastalıkları ve Doğum Polikliniğine başvuran 368 kadın ile gerçekleştirilmiştir. Veriler; Kişisel Bilgi Formu, Algılanan Duygusal İstismar Ölçeği, Eskin İntihara Karşı Tutumlar Ölçeği ve İntihar Davranış Ölçeği ile toplanmıştır. Verilerin analizi SPSS 25 paket programı ile yapılmıştır. Verilerin değerlendirilmesinde; Skewness ve Kurtosis değerleri, yüzde dağılımı, ortalama, standart sapma, min-max değerleri kullanılmıştır. Pearson korelasyon katsayısı ve Çoklu Doğrusal Regresyon Analizi kullanılmıştır. İstatistiksel anlamlılık seviyesi p<0.05 olarak alınmıştır.Bulgular: Kadınların Algılanan Duygusal İstismar Ölçeği ve İntihar Davranış Ölçeği toplam puan ortalaması sırasıyla 128.14±48.44 ve 1.23±1.87’dir. Kadınlarda Algılanan Duygusal İstismar Ölçeği toplam puan ortalamaları ile İntihar Davranış Ölçeği toplam puan ortalamaları, İntihar Davranış Ölçeği alt boyutlarından İntiharın kabul edilebilirliği arasında doğrusal ilişki vardır (p<0.001). Kadınların ekonomik durumu ile Algılanan Duygusal İstismar Ölçeği, Eskin İntihara Karşı Tutumlar Ölçeği ve İntihar Davranış Ölçeği toplam puan ortalamaları arasında istatistiksel olarak anlamlı ilişki vardır (p<0.05).Sonuç: Kadınların orta düzeyde duygusal istismar algıladıkları, intihar davranışlarının ve intihara karşı onaylayıcı tutumları düşük düzeyde olduğu bulundu. Düşük gelir durumu, sosyal güvencenin olmaması kadınların algılanan duygusal istismar düzeyi ve intihar davranışını arttırmaktadır.
Algebra Tiles as Physical Manipulatives to Support Students’ Understanding of Linear Equations in One Variable
Authors: Rini Dyah Sinto
Published: January 2023

To help students in solving the linear equations in one variable, teacher can use a learning media such as algebra tiles. Algebra tiles are square and rectangle-shaped tiles that represent numbers and variables. Algebra tiles consist of three different-size pieces. The smallest tile is square shape and represents ± 1, the other tile is rectangular shape and represents ± x and the largest tile is large square shape that represents ± x2. The pieces are usually colour-coded so that one colour represents positive values and another color represents negative values. This research is a best practice that was conducted at class VII.7 SMPN 18 Tangerang.  The aim of this research is to describe how the algebra tiles supports students’ understanding in solving linear equations in one variable. The competence achievement indicators are: modelling algebraic expressions using algebra tiles; solving linear equations in one variable using algebra tiles; solving linear equations in one variable without use algebra tiles. Data collection through photos, videos, worksheet and students’ work. Students did reducing and balancing ways to find the simple form of algebra tiles. The purpose of reducing or balancing of both sides of linear equations in one variable is to get how many square tiles that equals to one rectangular tile. Algebra tiles made students to be easier in solving linear equations in one variable. Students were very happy to learn mathematics using algebra tiles. The algebra tiles supports students’ understanding in solving linear equations in one variable.
The Questioning Techniques of Primary School Mathematics Teachers in their Journey to Incorporate Dialogic Teaching
Authors: Othman Rosni , Shahrill Masitah , Roslan Roslinawati , Nurhasanah Farida , Zakir Nordiana , Asamoah Daniel
Published: January 2023

Questioning is one of the critical repertoires in dialogic teaching. Teachers who set dialogic classrooms need to be able to use questioning effectively. Effective questioning techniques by teachers improve teacher-student instructional dialogues in primary school mathematics classrooms. In this study, the questioning practices of three primary school mathematics teachers were analysed in their journey to incorporate dialogic teaching. Data were gathered through lesson observations, video recordings and teacher interviews. The three teachers’ classroom discourses were transcribed verbatim, and teachers’ questions were analysed to find out the types of questions, how the teachers asked the questions and the feedback given to the student’s responses. Findings from this study indicated that the three teachers used effective questioning techniques in ensuring dialogic teaching, with focusing, genuine enquiry, and closed testing questions being the most predominant. The teachers portrayed positive attitudes towards dialogic teaching and shared their comprehensive understanding of the approach.
Yoğun Bakımda Takip Edilen Karbonmonoksit Zehirlenmeli Hastalarda COHb, Troponin I ve Laktat Düzeylerinin Prognoza Etkisi
Authors: BAŞARAN UYAR Emine , UYAR Hasan Gazi , KÖYLÜ Ramazan , AKILLI Nazire Belgin , KÖYLÜ Öznur
Published: January 2023

Amaç: Karbonmonoksit ,rengi olmayan,kokusuz,tatsız ve tahriş etmeyen bir gazdır ve karbon bazlı yakıtların yetersiz yanmasıyla oluşur.Karbonmonoksit zehirlenmesi ise önemli bir halk sağlı sorunudur ve tüm zehirlenme vakalarının %8-34 unu oluşturur.Bu çalışmanın amacı; yoğun bakımda karbonmonoksit zehirlenmesi ile takip ettiğimiz hastaların demografik,klinik ve tedavi özelliklerini karşılaştırmak, hastaların COHb,troponın I ve laktat düzeyleri ile klinik seyir ve sonuçları arasındaki ilişkiyi belirlemektir.
Araçlar ve yöntemler: Çalışmamızda; 01.01.2018- 31.12.2020 tarihleri arasında Konya Meram Devlet Hastanesi ve Konya Şehir Hastanesinde yoğun bakımda karbonmonoksit zehirlenmesi nedeniyle takip edilen 18 yaş üzerinde 214 hasta çalışmaya alındı. Çalışmaya alınan hastaların hastane veri tabanı kullanılarak retrospektif olarak dosya (epikriz, laboratuar sonuçları, Magnetik rezonans görüntüleme) kayıtları tarandı. Çeşitli demografik,klinik ve laboratuar özellikleri karşılaştırıldı. İstatistiksel analizler SPSS 19.0 for Windows ile yapıldı. P değeri <0,05 istatistiki olarak anlamlı kabul edildi.
Bulgular: Çalışmamızda COHb ortalama değeri 30,1±8,8 olarak geldi.Çalışmamızda kan laktat düzeyi ortalaması 2,9±2,0 mmol/L olarak geldi. Kan troponın I düzeyi 0,7±2,4 ng/ml olarak ölçüldü. Çalışmamızda; hastaların hiperbarik ve normobarik tedavi alıp almayacağını; kan troponın I ve COHb düzeyi etkilemiştir.(p<0,05)Laktat düzeyi ise istatistiki olarak etkilememiştir. Hiperbarik tedavi alanlarda troponın I ve COHb değeri daha yüksek bulunmuştur. Çalışmamızda EKG’ de iskemi bulgusu olup olmamasını; kan troponın I ve laktat düzeyi etkilemiş ( p<0,05) fakat COHb düzeyi istatistiki olarak etkilememiştir. Çalışmamızda MR’da iskemi olup olmamasını laktat ve troponın I etkilemiş(p<0,05) fakat COHb düzeyi istatistiki olarak etkilememiştir.MR’da iskemi olanlarda laktat ve troponın I değeri daha yüksek bulunmuştur. Yatış sürelerini; troponın I, laktat, ve COHb düzeyleri etkilemiştir. Troponın I,laktat ve COHb değeri arttıkça hastanede yatış süresi uzamıştır.
Sonuçlar: COHb,troponın I ve laktat düzeyleri karbonmonoksit zehirlenmeli hastalarda hastaların prognozunu etkilemektedir. Daha ileri çalışmalara ihtiyaç vardır.
Geopolitics of the Digital Economy: Implications for States and Firms
Authors: Lawton Thomas C. , Tonn Goulart Moura Stephanie , Tobin Damian , Silva-Rêgo Bernardo
Published: January 2023

The lack of boundaries in cyberspace contributes to geopolitical disputes, as data and technology are weaponized across borders, and hacking of critical infrastructure becomes pervasive. But we lack a framework for understanding the tangible impact of geopolitical tensions and digital proxy conflict on states and firms. We argue that governments and companies can gain insights into these tensions by examining who controls the main structural power pillars of the international political economy: production, security, knowledge, and finance. Based on this approach, we consider how policymakers and practitioners can engage and navigate digital geopolitics in an age of uncertainty.
Wellbeing for Whom Neoliberalism against the Environment in Climate Fiction
Authors: Šosterič Teja
Published: January 2023

The socio-economic environment in which climate fiction novels are produced and read influences their content. The three US novels discussed in this article (Jonathan Franzen’s Freedom (2011), Richard Powers’ The Overstory (2018), and T.C. Boyle’s A Friend of The Earth (2000)) reflect the neoliberal political and economic agenda, which does not focus on human or planetary wellbeing. Current socioeconomic priorities contradict the possibility of a sustainable future, which is increasingly affecting the daily lives of everyone on the planet, and environmental destruction is at the core of capitalist production. The emergence of cli-fi and neocli-fi parallels the rise of neoliberal ideology, and I explore the influence of that ideology on US and other western societies. As I demonstrate, this extends to novels, the narratives of which either attempt to satirize capitalism or subscribe to the idea that there is no alternative to the system. The ensuing aura of complacency is antithetical to action. However, analysing contemporary climate fiction novels written in the US may provide a framework for understanding the popular attitudes when it comes to the social, economic, and political reality and the potential to address the environmental disaster.
Book Review: At Home in the Anthropocene
Authors: Seymour Nicole
Published: January 2023

“Bomb cyclones,” megafires,commercial development, and other environmental disasters do not merely upset human habitats. They also upset those of our nonhuman kin, displacing them temporarilyoreven permanently,andoftenbringingus allin closer proximity. If ecology is the study of home—the word coming from the Greek oikos, for household—then the very foundations of that pursuithavebeen destabilized. Amy D. Propen’s2022bookAt Home in the Anthropocene takes this situationas its premise, asking us to explore“what counts as home?”(29) in such a fraught era.
Making with and Thinking through Compost
Authors: Chao Gwenyth
Published: January 2023

Slimy ridged bodies are squirming around. A cloud of winged black dots buzz and hover about. There is an odorthat smells like many microscopic corpses rotting. The ecosystems of these maggot-infestedfood scraps that colonize our green collection bins canbe seen as a more efficient and sustainable microcosm of my research on composting.
KELOMPOK RENTAN DAN TANTANGAN PEMILU INKLUSIF 2024 STUDI KASUS PERILAKU PEMILIH PADA KOMUNITAS MASYARAKAT DAYAK BUMI SEGANDU INDRAMAYU
Authors: Irawan Dede , Muh. Aripin Nurmanto
Published: January 2023

Komunitas Suku Dayak Hindu Buddha Bumi Segandu Kabupaten Indramayu sebagai kelompok masyarakat rentan yang menganut keyakinan ajaran “ngaji rasa”, salah satu implementasi ajaran tersebut adalah Golput. Tujuan penelitian ini untuk mengetahui perilaku pemilih dalam komunitas tersebut dengan harapan dapat mendorong Pemilu yang inklusif. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Adapun hasil penelitian menunjukan bahwa kelompok masyarakat Suku Dayak Bumi Segandu Kabupaten Indramayu tidak memberikan hak pilih dalam setiap pelaksanaan Pemilu dan Pemilihan dikarenakan dua faktor diantaranya 1) prinsip ajaran “ngaji rasa” yang mengedepankan instropeksi diri dan tidak ingin menyakiti satu sama lain, komunitas Dayak Indramayu mengaplikasikan ajaran tersebut dalam proses Pemilu dan Pemilihan dengan sikap Golput. Jika kelompok tersebut memilih salah satu calon berarti telah melanggar ajaran ngaji rasa karena dianggap telah menyakiti; 2) Stakeholder sudah memfasilitasi pendaftaran administrasi kependudukan akan tetapi tokoh Dayak Indramayu masih menolak untuk membuat Kartu Tanda Penduduk (KTP) elektronik.  Ajaran “ngaji rasa” tersebut bukan doktrin yang harus dikuti seluruh anggota komunitas tersebut, para istri, anak yang cukup usia, perempuan dalam komunitas tersebut diperbolehkan untuk memilih sebagai bentuk kebebasan politik dan juga diperbolehkan untuk mendapatkan surat administrasi kependudukan.
STATISTICAL ANALYSIS OF PRELIMINARY STUDIES FOR HEMP CONCRETE
Authors: ADASM Laurentiu , ISOPESCU Dorina-Nicolina , JUDELE Loredana , BUCUR Roxana Dana , LEPADATU Daniel
Published: January 2023

Waste is a major worldwide problem and its recycling has become mandatory in the current context of the decrease in natural resources. The management of recyclable waste improves the efficiency of any economic activities and the impact on the environment decreases proportionally to the quantities reused. With a significant impact on carbon dioxide emissions, the construction sector is one of the largest consumers of energy and raw materials. Hemp, and other biomass waste, are by-products in agriculture, making important contributions to the development of ecological materials by incorporating important quantities of such recyclable waste. This paper presents a series of different hemp concrete compositions that aim to obtain the optimum ratio between the binder and hemp shiv, in order to determine the inflection point towards which the delimitation can be made between insulating materials and materials with improved mechanical resistance. The importance of the work is given by the fact that, until now, the optimal proportion between the binder and hemp wood chips has not been demonstrated. This turning point must be justified by a variation of the mechanical resistance or a variation of the heat transfer coefficient, through the conductivity of the obtained samples. After preliminary testing, the statistical analysis will allow identification of the specific quantities needed to improve the physical-mechanical performance of the hemp-concrete recipe. Thus, by adding a justified amount of binder, an ecological material based on vegetable waste from agricultural crops is obtained. The material will have thermo-mechanical properties designed for a specific situation, required by the minimum performance imposed by the destination for which it will be made.
On the Dynamic Analysis of Freight Wagon-Track Interaction
Authors: SOYİÇ LEBLEBİCİ Aslı , TÜRKAY Semiha
Published: January 2023

In this study, a six-degrees-of-freedom half-car model for a freight wagon is used to study the ride motions of the vehicle under random rail inputs. As a rail input, the track profiles taken from Federal Railroad-Administration (FRA) international standard are used. A coupled vertical vehicle-track system is formed as a polytopic function of the track roughness parameter and vehicle speed and their influence on the vehicle dynamics is discussed. Then an optimization problem with a single objective function is formulated for a range of track roughness parameters and vehicle speeds. H_∞ control focuses on obtaining a robustness concerning the uncertainty of the system. So, we used H_∞ optimization to obtain the solutions while maximizing the trade-off between the respective performance indices. Later, a controller with a fixed speed value is synthesized and the results are compared by using the frequency response plots and the root-mean-square values of the car body accelerations and secondary and primary suspension deflections. The simulation results demonstrate that the active system is effective in improving ride comfort while keeping the rail holding within allowable limits.
Petri Net Modeling and Controller Design of Unistar CSV24 Point Machine
Authors: SOYİÇ LEBLEBİCİ Aslı
Published: January 2023

Railway transportation has become essential in transportation systems because of its fast, safe, cheap and environmentally friendly structure. The safe navigation of trains depends on the correct design of the signaling system and its components. Developing technology also brings about changes in the standards used in rail transportation systems such that the railway safety standards recommend using Petri Nets in the modeling of point machines, which are the most basic actuators of signaling systems. The working principle of point machines can be easily explained with Discrete Event Systems (DES). In this study, a model was created for the Unistar CSV24 point machine, which is widely used in Turkey, by using Petri Nets. The validation of obtained model was verified using the TAPAAL interface. Electromechanical and Programmable Logic Control (PLC) solutions are presented to control the verified model. Siemens TIA PORTAL was used to obtain the PLC block of the point machine.
Prolonged jaundice after previous SARS-CoV-2 infection: a clinical case report
Authors: Vacheishvili N. G. , Zharkova M. S. , Nekrasova T. P. , Tikhonov I. N. , Trofimovskaya N. I. , Ivashkin V. T.
Published: January 2023

The hepatobiliary system can be affected by a new coronavirus infection (COVID-19), in addition to the respiratory organs. Vanishing bile duct syndrome (VBDS) is a rare cause of jaundice that usually develops as a result of drug-induced liver injury or possibly due to the combined effect of several etiological factors.

Clinical case. A 77-year-old patient was hospitalized due to jaundice, skin itching and dark urine. Symptoms first appeared 1 month after COVID-19 treated with ceftriaxone and were accompanied by an increase in biochemical markers of cholestasis. Both extra- and intrahepatic bile ducts injuries were excluded. Liver histology revealed VBDS. Treatment with ursodeoxycholic acid for 11 months led to complete resolution of jaundice, regression of pruritus and a decrease in biochemical markers of cholestasis.

Discussion. This clinical case is of interest in connection with the development of VBDS in a patient after coronavirus pneumonia treated with ceftriaxone. VBDS is rarely included in the differential diagnosis of cholestatic syndrome, which is partly due to the lack of awareness of physicians about the complications that develop after COVID-19 and drug therapy.
The Effectiveness of Kenikir Leaf Extract (Cosmos Caudatus Kunth) on Bleeding Time in Mice (Mus Musculus) Tails
Authors:   Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Jember, Jember –Indonesia, Yuwono Budi , Sari Ega Tiara Iman ,   Faculty of Dentistry, University of Jember, Jember –Indonesia, Nurul Amin Muhammad ,   Department of Biomedical, Faculty of Dentistry, University of Jember, Jember –Indonesia, Sulistiyani Sulistiyani ,   Department of Pediatric Dentistry University of Jember, Jember, Indonesia, Setyorini Dyah ,   Department of Pediatric Dentistry University of Jember, Jember, Indonesia
Published: January 2023

Background: Continuous bleeding will inhibit the formation of blood clots and cause the wound healing process to be hampered, thereby endangering the patient's life. Kenikir leaves contain flavonoid compounds, tannins, and saponins which have the potential as natural hemostatic agents in shortening bleeding time. Aim: To analyze the effectiveness of kenikir leaf extract (Cosmos caudatus kunth) on bleeding time in the tails of mice (Mus musculus). Material and Methods: This type of research is a laboratory experiment with a post test only control group design method. The samples used were 12 mice and divided into 3 groups, namely negative control (K-), positive control (K+), and treatment (P). All samples were adapted for 7 days, then fasted for 4 hours, then given each ingredient according to the group, then waited for 60 minutes and cut the mice tails along 0.5 cm from the tail end. Blood is dropped on filter paper every 30 seconds until the bleeding stops, the results of the calculation of bleeding time were analyzed using the Anova and LSD analysis. Results: The average bleeding time in the K-, K+, and P groups was 7.25 minutes, 1.87 minutes and 3.37 minutes. Anova analysis results obtained a significance value (p<0.05), which means that there are differences in all groups. LSD analysis showed that there were significant differences between K- and K+ groups and K- and P groups, whereas in the K+ and P groups no significant differences. Conclusion: Kenikir leaf extract can shorten the bleeding time in mice tails.
Patient Non-Compliance: A Barrier to Successful Outcomes in Medicine and Healthcare Service
Authors:   4th Year medical student, Barry University School of Podiatric Medicine Miami, FL USA, Chittenden Keith
Published: January 2023

This is a research-based perspective article into patient non-compliance within the domains of medicine, physical rehabilitation, and exercise/strength and conditioning. The article identifies major pillars behind patient non-compliance: age, education, motivation, and trust as being the most influential variables that affects the amount of compliance a patient has with medical/exercise and therapeutic treatments. The article summarizes research that has identified theses variables and gives pragmatic options to help reduce the occurrence of ongoing patient non-compliance. Communication, patient compliance, motivational interviewing, virtual information gathering and barrier identity are all techniques discussed to overcome patient non-compliance. There are pragmatic tips for medical providers, therapists and trainers to assist in the management of non-compliance in their patients and clients in all aspects of practice in an evidence-based approach.
Colon Cancer with Thyroid Metastasis – A Case Report
Authors:   Cancer Hospital of Londrina (Resident Clinical Oncology, Londrina, Paraná), Brazil, Ferrari Manéa Rafael Ricci , Oliveira Rivadavio Antunes M. de ,   Cancer Hospital of Londrina (Clinical Oncology Preceptor, Londrina, Paraná), Brazil
Published: January 2023

Introduction: Metastasis in the thyroid itself, is unusual, represents 1.5-7.5% of malignant thyroid lesions and the original site of the colon is rare, around 0.1% incidence. The objective is to report the case of a patient diagnosed with colorectal cancer which progressed to thyroid disease. Case Report: It is a 62-year-old male patient who was being followed up at the Cancer Hospital of Londrina due to the resected colon neoplasm, which evolved with disease recurrence for the liver and lung and was controlled with systemic chemotherapy. It evolved with progression to thyroid and it was opted for diagnostic surgical resection. Conclusion: In the case demonstrated, it is a rare presentation of colon cancer metastasis and there is no current literature which would be a better therapeutic approach; surgery or palliative systemic chemotherapy. In this scenario, the importance of reporting cases little described in the literature may help in the decision of future conduct.
ACTS OF JUDICIAL INTERPRETATION OF LAW AS A SUBJECT CONSTITUTIONAL JUSTICE
Authors: Abdullayeva Maftuna
Published: January 2023

There are two main points of view on the problem of the legal nature of documents interpreting constitutional and legal norms. One of them is that the interpretation should determine the true meaning and content of the legal norm in its essence, and not introduce any new information into the provision being clarified. Its main task is to clarify and highlight the content of existing norms. Another point of view is to recognize the normative nature of interpretive documents. The author examines whether acts of judicial interpretation can be the subject of constitutional justice, based on an analysis of the nature of the plenums of higher courts. And also, the article is devoted to some theoretical problems of determining the legal nature of the decisions of the Plenum of the Supreme Court and their role in establishing the uniformity of judicial practice.
RELATIONSHIP OF ENVIRONMENTAL IMPACT ASSESSMENT AND ENVIRONMENTAL EXPERTISE
Authors: Akhmedova Shakhnoza
Published: January 2023

This article discusses issues related to the procedures for assessing the impact on the environment, environmental expertise and strategic environmental expertise of the planned economic and other activities in national legislation and international documents. The actual problems of the lack of a specific range of objects of expertise and other mechanisms of environmental protection measures are determined.