bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1 through 12 from An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers
Authors: Prueitt Robyn L. , Wallace Tiffany A. , Glynn Sharon A. , Yi Ming , Tang Wei , Luo Jun , Dorsey Tiffany H. , Stagliano Katherine E. , Gillespie John W. , Hudson Robert S. , Terunuma Atsushi , Shoe Jennifer L. , Haines Diana C. , Yfantis Harris G. , Han Misop , Martin Damali N. , Jordan Symone V. , Borin James F. , Naslund Michael J. , Alexander Richard B. , Stephens Robert M. , Loffredo Christopher A. , Lee Dong H. , Putluri Nagireddy , Sreekumar Arun , Hurwitz Arthur A. , Ambs Stefan
Published: April 2023

Supplementary Figure S1: Weight curves for untreated TRAMP mice and TRAMP mice treated with nicotine for 80 days. Supplementary Figure S2: Ig lambdaâ€� and Ig kappaâ€�positive B lymphocytes in cancerous prostate tissue by inâ€�situ hybridization. Supplementary Figure S3: qRTâ€�PCR validation of six genes upâ€�regulated among current smokers. Supplementary Figure S4: Analysis of prostate tumors using Bioconductor limma R. Supplementary Figure S5: Gene Set Enrichment Analysis (GSEA) highlighting common features between smokingâ€�related gene signatures in prostate tumors, nicotineâ€�induced gene signatures in human prostate cancer cells, and gene signatures archived in the GSEA database. Supplementary Figure S6: Expression of various nicotinic acetylcholine receptor (AChR) subunits in human prostate cancer cell lines, prostate tumors, and adjacent nonâ€�tumor prostate tissues. Supplementary Figure S7: Nicotineâ€�mediated Akt activation in human immortalized prostate epithelial cells and prostate cancer cell lines. Supplementary Figure S8: Effect of nicotine on the mobility of human prostate cancer cell lines. Supplementary Figure S9: Nicotine enhances cell surface integrin expression and extracellular matrix binding (ECM) of 22Rv1 human prostate cancer cells. Supplementary Figure S10: Nicotine enhances proliferation of RWPEâ€�1 in complete Kâ€�SFM medium but not in Kâ€�SFM medium without EGF and bovine pituitary extract. Supplementary Figure S11: Nicotine did not enhance proliferation of 22Rv1 and PCâ€�3 human prostate cancer cells. Supplementary Figure S12: Lymphotoxinâ€�Î² plasma levels in prostate cancer patients (Case) and populationâ€�based controls (Control) by smoking status.
Supplementary Figure Legends from Checkpoint Antibodies but not T Cell–Recruiting Diabodies Effectively Synergize with TIL-Inducing γ-Irradiation
Authors: Hettich Michael , Lahoti Jayashree , Prasad Shruthi , Niedermann Gabriele
Published: April 2023

Figure legends to supporting figures 1-8.
Supplementary Figure Legends from DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair
Authors: Ying Songmin , Chen Zhihui , Medhurst Annette L. , Neal Jessica A. , Bao Zhengqiang , Mortusewicz Oliver , McGouran Joanna , Song Xinming , Shen Huahao , Hamdy Freddie C. , Kessler Benedikt M. , Meek Katheryn , Helleday Thomas
Published: April 2023

Supplementary Figure Legends
Supplementary Figure S1 from Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity
Authors: Pasero Christine , Gravis Gwenaëlle , Guerin Mathilde , Granjeaud Samuel , Thomassin-Piana Jeanne , Rocchi Palma , Paciencia-Gros Maria , Poizat Flora , Bentobji Mélanie , Azario-Cheillan Francine , Walz Jochen , Salem Naji , Brunelle Serge , Moretta Alessandro , Olive Daniel
Published: April 2023

Phenotype of NK cells infiltrating tumor prostate tissues compared to paired peripheral NK cells (pB-PC).
Figure S7 from Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells
Authors: Cao Ji , Wang Yijie , Dong Rong , Lin Guanyu , Zhang Ning , Wang Jing , Lin Nengming , Gu Yongchuan , Ding Ling , Ying Meidan , He Qiaojun , Yang Bo
Published: April 2023

Time-lapse movie of representative KHOS/NP cells infected with lentivirus-WSB1 on gelatin-coated surfaces.
Supplementary Figures 1 through 6 from IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis
Authors: Rajurkar Mihir , Dang Kyvan , Fernandez-Barrena Maite G. , Liu Xiangfan , Fernandez-Zapico Martin E. , Lewis Brian C. , Mao Junhao
Published: April 2023

Figure S1: Immunohistochemistry staining and quantification of IKBKE and TBK1 in human PDAC tissue microarray, and normal pancreas Figure S2: qRT-PCR and western blot showing IKBKE/TBK1 levels in response to KRAS knockdown, and effect of KRAS/IKBKE/TBK1 knockdown on PDAC cell survival and proliferation Figure S3: Histological and immunohistochemical analysis of wild type and IKBKE-null mouse pancreas Figure S4: Ki67 immunohistochemistry and quantification in age matched PanIN lesions from mice Figure S5: Characterization of stable cell lines carrying inducible IKBKE/mTOR knockdown Figure S6: Immunohistochemistry showing AKT and S6K phosphorylation in xenograft mice with IKBKE/mTOR knockdown
Supplemental Figures S1-S5 from MYC Is a Crucial Mediator of TGFβ-Induced Invasion in Basal Breast Cancer
Authors: Cichon Magdalena A. , Moruzzi Megan E. , Shqau Tiziana A. , Miller Erin , Mehner Christine , Ethier Stephen P. , Copland John A. , Radisky Evette S. , Radisky Derek C.
Published: April 2023

Responsiveness of different molecular subtypes breast cancer cell lines to TGFÎ² as measured by PAI-1 expression levels (S1); TGFÎ²ï�¢and MYC knockdown inhibit cell proliferation (S2); MYC reduction potentiates TGFÎ² induced invasive phenotype in SUM149 cells (S3); Pharmacological inhibition of SRC blocks the effect of TGFÎ² treatment on increased levels of integrin Î±vÎ²3 (S4); Pharmacological inhibition of MYC mimics the effect of MYC knockdown on integrin Î±vÎ²3 levels, in a dose dependent manner (S5).
Supplemental Tables S1, S4 and S5 from Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression
Authors: De Smedt Eva , Maes Ken , Verhulst Stefaan , Lui Hui , Kassambara Alboukadel , Maes Anke , Robert Nicolas , Heirman Carlo , Cakana Andrew , Hose Dirk , Breckpot Karine , van Grunsven Leo A. , De Veirman Kim , Menu Eline , Vanderkerken Karin , Moreaux Jérôme , De Bruyne Elke
Published: April 2023

Supplemental Table S1 summarizes the patient characteristics. Supplemental Table S4 provides an overview of all kinases differentially phosphorylated in RASSF4 overexpressing cells treated with trametinib compared to parental cells treated with trametinib and/or RASSF4 overexpressing cells. Supplemental Table S5 summarizes significance and combination index (CI) values calculated for the different drug concentrations used in the combination experiments.
Supplementary Figure Legends from Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer
Authors: Rao Chinthalapally V. , Janakiram Naveena B. , Madka Venkateshwar , Kumar Gaurav , Scott Edgar J. , Pathuri Gopal , Bryant Taylor , Kutche Hannah , Zhang Yuting , Biddick Laura , Gali Hariprasad , Zhao Yan D. , Lightfoot Stan , Mohammed Altaf
Published: April 2023

Supplementary Figure Legends
Supplementary Figure 1 from Small-Molecule Inhibition of GCNT3 Disrupts Mucin Biosynthesis and Malignant Cellular Behaviors in Pancreatic Cancer
Authors: Rao Chinthalapally V. , Janakiram Naveena B. , Madka Venkateshwar , Kumar Gaurav , Scott Edgar J. , Pathuri Gopal , Bryant Taylor , Kutche Hannah , Zhang Yuting , Biddick Laura , Gali Hariprasad , Zhao Yan D. , Lightfoot Stan , Mohammed Altaf
Published: April 2023

Kaplan-Meier analysis of patients' survival by sex
Supplementary Tables 1 through 3 from Systemic DC Activation Modulates the Tumor Microenvironment and Shapes the Long-Lived Tumor-Specific Memory Mediated by CD8+ T Cells
Authors: Shimizu Kanako , Yamasaki Satoru , Shinga Jun , Sato Yusuke , Watanabe Takashi , Ohara Osamu , Kuzushima Kiyotaka , Yagita Hideo , Komuro Yoshiko , Asakura Miki , Fujii Shin-ichiro
Published: April 2023

Table S1 The antibodies used in this study Table S2 The specific Primer sequences used for real-time PCR Table S3 TCRbeta deep sequencing of OVA-tetramer+ CD8 T cells in spleen and TIL
Supplementary Figure 4 from A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
Authors: Liu Xiaojun , Ranganathan Raghuveer , Jiang Shuguang , Fang Chongyun , Sun Jing , Kim Soyeon , Newick Kheng , Lo Albert , June Carl H. , Zhao Yangbing , Moon Edmund K.
Published: April 2023

Ex-vivo killing of and cytokine secretion in response to tumor targets by TILs isolated from EMMESO flank tumors.
Supplemental Figure S8 from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Authors: Tian Yuan , Wong Vincent W.S. , Wong Grace L.H. , Yang Weiqin , Sun Hanyong , Shen Jiayun , Tong Joanna H.M. , Go Minnie Y.Y. , Cheung Yue S. , Lai Paul B.S. , Zhou Mingyan , Xu Gang , Huang Tim H.M. , Yu Jun , To Ka F. , Cheng Alfred S.L. , Chan Henry L.Y.
Published: April 2023

HDAC8 expression positively correlates with its signaling components in primary human NAFLD-associated HCCs.
Supplementary Figure 5 from Infiltrating Macrophages Induce ERα Expression through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen
Authors: Ning Chengcheng , Xie Bingying , Zhang Lin , Li Chunsheng , Shan Weiwei , Yang Bingyi , Luo Xuezhen , Gu Chao , He Qizhi , Jin Hongyan , Chen Xiaojun , Zhang Zhenbo , Feng Youji
Published: April 2023

IL-17A or overexpression of ERα promoted estradiol-driven endometrial cancer cell proliferation
Supplemental Figure S1 from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Authors: Tian Yuan , Wong Vincent W.S. , Wong Grace L.H. , Yang Weiqin , Sun Hanyong , Shen Jiayun , Tong Joanna H.M. , Go Minnie Y.Y. , Cheung Yue S. , Lai Paul B.S. , Zhou Mingyan , Xu Gang , Huang Tim H.M. , Yu Jun , To Ka F. , Cheng Alfred S.L. , Chan Henry L.Y.
Published: April 2023

Up-regulation of HDAC8 in murine NAFLD-associated HCC models.
Supplemental Figure Legends from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Authors: Tian Yuan , Wong Vincent W.S. , Wong Grace L.H. , Yang Weiqin , Sun Hanyong , Shen Jiayun , Tong Joanna H.M. , Go Minnie Y.Y. , Cheung Yue S. , Lai Paul B.S. , Zhou Mingyan , Xu Gang , Huang Tim H.M. , Yu Jun , To Ka F. , Cheng Alfred S.L. , Chan Henry L.Y.
Published: April 2023

Legend for Supplemental Figures S1-S8.
Supplementary Figure 1 from Infiltrating Macrophages Induce ERα Expression through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen
Authors: Ning Chengcheng , Xie Bingying , Zhang Lin , Li Chunsheng , Shan Weiwei , Yang Bingyi , Luo Xuezhen , Gu Chao , He Qizhi , Jin Hongyan , Chen Xiaojun , Zhang Zhenbo , Feng Youji
Published: April 2023

Serum estradiol levels were not elevated in patients with endometrioid adenocarcinoma after stratification by pathologic grading
Supplementary Figure S2 from MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Su Li , Luo Yongli , Yang Zhi , Yang Jing , Yao Chao , Cheng Feifei , Shan Juanjuan , Chen Jun , Li Fangfang , Liu Limei , Liu Chungang , Xu Yanmin , Jiang Lupin , Guo Deyu , Prieto Jesus , Ávila Matías A. , Shen Junjie , Qian Cheng
Published: April 2023

MEF2D transcriptionally regulates ZEB1.
Doxorubicin treatments (raw data) in human HCC cell lines from Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma
Authors: Wolf Benita , Krieg Kathrin , Falk Christine , Breuhahn Kai , Keppeler Hildegard , Biedermann Tilo , Schmid Evi , Warmann Steven , Fuchs Joerg , Vetter Silvia , Thiele Dennis , Nieser Maike , Avci-Adali Meltem , Skokowa Yulia , Schöls Ludger , Hauser Stefan , Ringelhan Marc , Yevsa Tetyana , Heikenwalder Mathias , Kossatz-Boehlert Uta
Published: April 2023

Supplemental Figure 5 data file
Supplementary Table S4 from Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1
Authors: Dubey Ramin , Lebensohn Andres M. , Bahrami-Nejad Zahra , Marceau Caleb , Champion Magali , Gevaert Olivier , Sikic Branimir I. , Carette Jan E. , Rohatgi Rajat
Published: April 2023

Statistical Tests for several key comparisons in the manuscript.
Supplementary Table 2 from Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins
Authors: Hitti Edward , Bakheet Tala , Al-Souhibani Norah , Moghrabi Walid , Al-Yahya Suhad , Al-Ghamdi Maha , Al-Saif Maher , Shoukri Mohamed M. , Lánczky András , Grépin Renaud , Győrffy Balázs , Pagès Gilles , Khabar Khalid S.A.
Published: April 2023

Overall list the over-expressed ARE-mRNAs in breast cancer.
Supplementary Figure Legends from NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer–Initiating Cells
Authors: Srinivasan Tara , Walters Jewell , Bu Pengcheng , Than Elaine Bich , Tung Kuei-Ling , Chen Kai-Yuan , Panarelli Nicole , Milsom Jeff , Augenlicht Leonard , Lipkin Steven M. , Shen Xiling
Published: April 2023

Contains Supplementary Figure legends for Supplementary Figures 1-6.
Supplementary Figure 4 from NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress–Induced DPP3–KEAP1 Interaction
Authors: Lu Kevin , Alcivar Allen L. , Ma Jianglin , Foo Tzeh Keong , Zywea Susan , Mahdi Amar , Huo Yanying , Kensler Thomas W. , Gatza Michael L. , Xia Bing
Published: April 2023

Effect of mutating individual cysteine residues of KEAP1 on DPP3 binding.
Supplementary figures legends from Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients
Authors: Dominguez–Valentin Mev , Gras Navarro Andrea , Rahman Aminur Mohummad , Kumar Surendra , Retière Christèle , Ulvestad Elling , Kristensen Vessela , Lund-Johansen Morten , Lie Benedicte Alexandra , Enger Per Øyvind , Njølstad Gro , Kristoffersen Einar , Lie Stein Atle , Chekenya Martha
Published: April 2023

Supplementary figures legends
Supplementary Table S4 from High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells
Authors: Horn Thomas , Ferretti Stéphane , Ebel Nicolas , Tam Angela , Ho Samuel , Harbinski Fred , Farsidjani Ali , Zubrowski Matthew , Sellers William R. , Schlegel Robert , Porter Dale , Morris Erick , Wuerthner Jens , Jeay Sébastien , Greshock Joel , Halilovic Ensar , Garraway Levi A. , Caponigro Giordano , Lehár Joseph
Published: April 2023

Summarized results of pair-wise and triple combination screens.
Supplementary Figure S1 from HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone
Authors: Day Kathleen C. , Hiles Guadalupe Lorenzatti , Kozminsky Molly , Dawsey Scott J. , Paul Alyssa , Broses Luke J. , Shah Rajal , Kunja Lakshmi P. , Hall Christopher , Palanisamy Nallasivam , Daignault-Newton Stephanie , El-Sawy Layla , Wilson Steven James , Chou Andrew , Ignatoski Kathleen Woods , Keller Evan , Thomas Dafydd , Nagrath Sunitha , Morgan Todd , Day Mark L.
Published: April 2023

Epitopes and staining characteristics of HER2 antibodies.
Supplementary figures and tables from Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity
Authors: Lin Sheng-Chieh , Chou Yu-Ting , Jiang Shih Sheng , Chang Junn-Liang , Chung Chih-Hung , Kao Yu-Rung , Chang I-Shou , Wu Cheng-Wen
Published: April 2023

This file contains following figures and tables: Fig. S1. Differential effects of cisplatin on SOX2- and SOX9-positive lung cancer cells (related to Fig. 1); Fig. S2. STR profiling in the derived stable clones (related to Fig. 2); Fig. S3. Expression switching between SOX2 and SOX9 (related to Fig. 2 and 3); Fig. S4. Ectopic expression of SOX2 attenuates SOX9 expression (related to Fig. 3); Fig. S5. Differential effects of SOX2 and SOX9 on cell proliferation (related to Fig. 3 and 4); Fig. S6. CCNA2-silencing attenuates cell growth in CL1-0 cells (related to Fig. 3); Fig. S7. SOX9-silencing attenuates lung invasion (related to Fig. 5); Fig. S8. Switching enrichment of H3K9me2 between CL1-1 and CL1-2 cells (related to Fig. 6); Fig. S9. Correlation analysis of SOX2 with SOX9, CCNA2 and HDAC1 in primary lung adenocarcinoma (related to Fig. 7); Fig. S10. Model for cancer cell plasticity (related to Fig. 1 to 7); Table S1. shRNA clones used in this study; Table S2. Primary antibodies used in this study; Table S3. Primers and probes used in this study; Table S4. Gene expression profiling data from the public domain used in this study.
Supplemental Figures from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2
Authors: Eytan Danielle F. , Snow Grace E. , Carlson Sophie , Derakhshan Adeeb , Saleh Anthony , Schiltz Stephen , Cheng Hui , Mohan Suresh , Cornelius Shaleeka , Coupar Jamie , Sowers Anastasia L. , Hernandez Lidia , Mitchell James B. , Annunziata Christina M. , Chen Zhong , Van Waes Carter
Published: April 2023

Supplemental Figures and Legends: Supplemental Figure 1. Effect of Birc2, Birc3, and FADD knockdown in UM-SCC-1 and UM-SCC-11A; Supplemental Figure 2. Summary of DNA cell cycle cytofluorometry in UM-SCC lines; Supplemental Figure 3. Effect of birinapant treatment and/or BIRC2 siRNA knockdown on cell IAP death pathway components and cell survival; Supplemental Figure 4: The average body weight of mice in all treatment groups before, during, and after the treatment period; Supplemental Figure 5. In vitro effect of birinapant on radiosensitivity of UM-SCC-46 cells; Supplemental Figure 6: Combination of birinapant plus radiation induces tumor regression and regrowth delay in UM-SCC-11B xenograft model, but not in the UM-SCC-1 xenograft model.
Supplementary Materials and Methods from p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
Authors: Lam Hilaire C. , Baglini Christian V. , Lope Alicia Llorente , Parkhitko Andrey A. , Liu Heng-Jia , Alesi Nicola , Malinowska Izabela A. , Ebrahimi-Fakhari Darius , Saffari Afshin , Yu Jane J. , Pereira Ana , Khabibullin Damir , Ogorek Barbara , Nijmeh Julie , Kavanagh Taylor , Handen Adam , Chan Stephen Y. , Asara John M. , Oldham William M. , Diaz-Meco Maria T. , Moscat Jorge , Sahin Mustafa , Priolo Carmen , Henske Elizabeth P.
Published: April 2023

Supplementary Materials and Methods
Supplementary Methods from Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma
Authors: English William R. , Lunt Sarah Jane , Fisher Matthew , Lefley Diane V. , Dhingra Mohit , Lee Yu-Chin , Bingham Karina , Hurrell Jack E. , Lyons Scott K. , Kanthou Chryso , Tozer Gillian M.
Published: April 2023

The supplementary methods file contains additional detailed information regarding: 1. The production of cell lines stably expressing luciferase. 2. Mouse strains and pre-clinical models of tumor growth and metastasis. 3. Acquisition and analysis of bioluminescence data from preclinical and in vitro studies. 4. Acquisition and analysis of in vitro migration data. 5. Antibodies and immuno-techniques used within this study.
Figure S8 from INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells
Authors: Morris Christelle , Tomimatsu Nozomi , Burma Sandeep , Jalinot Pierre
Published: April 2023

S8 illustrates the defect in the presence of phospho-MDC1 at DNA damage foci in INT6-silenced cells
Supplementary Figure S3 from IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition
Authors: Gaggianesi Miriam , Turdo Alice , Chinnici Aurora , Lipari Elisa , Apuzzo Tiziana , Benfante Antonina , Sperduti Isabella , Di Franco Simone , Meraviglia Serena , Lo Presti Elena , Dieli Francesco , Caputo Valentina , Militello Gabriella , Vieni Salvatore , Stassi Giorgio , Todaro Matilde
Published: April 2023

IL-4DM up-regulates DUSP4 expression
Supplementary Material and Methods from Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis
Authors: Verma Nandini , Müller Anna-Katharina , Kothari Charu , Panayotopoulou Effrosini , Kedan Amir , Selitrennik Michael , Mills Gordon B. , Nguyen Lan K. , Shin Sungyoung , Karn Thomas , Holtrich Uwe , Lev Sima
Published: April 2023

Supplemental Material and Methods
Supplementary Figure 8 from αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor
Authors: Lu Huimin , Wang Tao , Li Jing , Fedele Carmine , Liu Qin , Zhang Jianzhong , Jiang Zhong , Jain Dhanpat , Iozzo Renato V. , Violette Shelia M. , Weinreb Paul H. , Davis Roger J. , Gioeli Daniel , FitzGerald Thomas J. , Altieri Dario C. , Languino Lucia R.
Published: April 2023

Expression of beta3/6 integrin chimera in LNCaP Cells.
Supplementary Figure S2 from Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy
Authors: Ingle James N. , Xie Fang , Ellis Matthew J. , Goss Paul E. , Shepherd Lois E. , Chapman Judith-Anne W. , Chen Bingshu E. , Kubo Michiaki , Furukawa Yoichi , Momozawa Yukihide , Stearns Vered , Pritchard Kathleen I. , Barman Poulami , Carlson Erin E. , Goetz Matthew P. , Weinshilboum Richard M. , Kalari Krishna R. , Wang Liewei
Published: April 2023

Quantile-Quantile plot of observed vs. expected p-values under the null hypothesis of no SNP association with breast cancer-free interval for patients treated with anastrozole or exemestane.
Supplementary Figures and Legends from tRF/miR-1280 Suppresses Stem Cell–like Cells and Metastasis in Colorectal Cancer
Authors: Huang Bingqing , Yang Huipeng , Cheng Xixi , Wang Dan , Fu Shuyu , Shen Wencui , Zhang Qi , Zhang Lijuan , Xue Zhenyi , Li Yan , Da Yurong , Yang Qing , Li Zesong , Liu Li , Qiao Liang , Kong Ying , Yao Zhi , Zhao Peng , Li Min , Zhang Rongxin
Published: April 2023

Supplementary Figure 1, The expression levels of pre-miRNA-1280 and tRNALeu in CRC patients. Supplementary Figure 2, tRF/miR-1280 inhibits proliferation of Colorectal Cancer Cells in vitro and in vivo. Supplementary Figure 3, Prediction of target candidates for tRF/miR-1280. Supplementary Figure 4, tRF/miR-1280 inhibits Notch pathways and suppresses the stem cell-like phenotype.Supplementary Figure 5,JAG2 knockdown decreases Colorectal Cancer Cell growth.Supplementary Figure 6,tRF/miR-1280 reduces Gata1/3 expression, and knockdown of Gata1 or Gata3 decreases Colorectal Cancer Cells growth. Supplementary Figure 7, miR-200b targets Zeb1 and Suz12.
Supplementary Figure 7 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
Authors: Chen Justin L. , Walton Kelly L. , Qian Hongwei , Colgan Timothy D. , Hagg Adam , Watt Matthew J. , Harrison Craig A. , Gregorevic Paul
Published: April 2023

In mice injected with AAV:activin A and/or AAV:IL6, the liver was examined for expression of extracellular matrix genes and collagen deposition.
Table S1 from Tissue-Specific Signaling Networks Rewired by Major Somatic Mutations in Human Cancer Revealed by Proteome-Wide Discovery
Authors: Zhao Junfei , Cheng Feixiong , Zhao Zhongming
Published: April 2023

Summary of the number of phosphorylation site mutations in pan-cancer and each cancer type.
Supplemental Figure S5 from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma
Authors: Li Huaibiao , Frappart Lucien , Moll Jürgen , Winkler Anne , Kroll Torsten , Hamann Jana , Kufferath Iris , Groth Marco , Taudien Stefan , Schütte Moritz , Yaspo Marie-Laure , Heuer Heike , Lange Bodo M.H. , Platzer Matthias , Zatloukal Kurt , Herrlich Peter , Ploubidou Aspasia
Published: April 2023

Identification of RHAMM regulators via RNAi screening.
Supplemental Figure S4 from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma
Authors: Li Huaibiao , Frappart Lucien , Moll Jürgen , Winkler Anne , Kroll Torsten , Hamann Jana , Kufferath Iris , Groth Marco , Taudien Stefan , Schütte Moritz , Yaspo Marie-Laure , Heuer Heike , Lange Bodo M.H. , Platzer Matthias , Zatloukal Kurt , Herrlich Peter , Ploubidou Aspasia
Published: April 2023

Expression & regulation of TGCT susceptibility genes.
Supplemental Figure Legends from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma
Authors: Li Huaibiao , Frappart Lucien , Moll Jürgen , Winkler Anne , Kroll Torsten , Hamann Jana , Kufferath Iris , Groth Marco , Taudien Stefan , Schütte Moritz , Yaspo Marie-Laure , Heuer Heike , Lange Bodo M.H. , Platzer Matthias , Zatloukal Kurt , Herrlich Peter , Ploubidou Aspasia
Published: April 2023

Legends of supplemental figures S1-S5
Supplementary Figures from Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth
Authors: Haesen Dorien , Abbasi Asbagh Layka , Derua Rita , Hubert Antoine , Schrauwen Stefanie , Hoorne Yana , Amant Frédéric , Waelkens Etienne , Sablina Anna , Janssens Veerle
Published: April 2023

Supplemental Figure 1: Cellular binding assays in HEK293 cells, assessing binding of B55/B, B56/B' and PR72/B" subunits to endometrial cancer-associated AÎ± mutants. Supplemental Figure 2: Comparative analysis of binding of AÎ± mutants and endogenous PP2Ac to GFP-tagged B-type subunits in HEK293 cells. Supplemental Figure 3: Select B-type subunits can bind AÎ± independently of AÎ±-C interaction Supplemental Figure 4: 47 putatively novel AÎ± interactors revealed by mass spectrometry-based identification of WT and mutant AÎ± interactomes in HEC-1-A cells. Supplemental Figure 5: Biochemical characterization of TIPRL1-AÎ± complexes. Supplemental Figure 6: GFP-trapping assays showing that TIPRL1 can be retrieved in a complex with B56Î'. Supplemental Figure 7: FLAG pull downs showing that B55Î±, B56Î± and B56Î' can be retrieved in a complex with TIPRL1. Supplemental Figure 8: Quantifications of the effects of mutant AÎ± expression on oncogenic signaling in HEC-1-A cells Supplemental Figure 9: Increasing levels of AÎ± mutant P179R, but not WT AÎ±, lead to increased changes in oncogenic signaling in HEC-1-A endometrial cancer cells.
Supplementary data from E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia
Authors: Duque-Afonso Jesús , Lin Chiou-Hong , Han Kyuho , Wei Michael C. , Feng Jue , Kurzer Jason H. , Schneidawind Corina , Wong Stephen Hon-Kit , Bassik Michael C. , Cleary Michael L.
Published: April 2023

Supplementary data provide further supportive evidence that E2A-PBX1 binds the regulatory regions of its target genes (Supplementary Figure 1), which are expressed in primary ALLs depending on karyotype (Supplementary Figure 2), and have oncogenic roles in a mouse model of E2A-PX1 leukemia (Supplementary Figure 3) dependent on their genetic interactions to support proliferation and survival (Supplemental Figure 4). Additional supportive data demonstrate that genetic depletion of target gene expression enhances small molecule effects targeting the respective kinases (Supplemental Figure 5), which provides further rationale for combination kinase targeted therapy in E2A-PBX1+ ALL (Supplemental Figure 6)
Figure S1 from Individualized Breast Cancer Characterization through Single-Cell Analysis of Tumor and Adjacent Normal Cells
Authors: Anjanappa Manjushree , Cardoso Angelo , Cheng Lijun , Mohamad Safa , Gunawan Andrea , Rice Susan , Dong Yan , Li Lang , Sandusky George E. , Srour Edward F. , Nakshatri Harikrishna
Published: April 2023

Figure S1 shows expression pattern of stemless associated genes in tumor and adjacent normal cells of patient 4
Supplementary Figure S6 from Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Authors: Schwartz Hila , Blacher Eran , Amer Malak , Livneh Nir , Abramovitz Lilach , Klein Anat , Ben-Shushan Dikla , Soffer Shelly , Blazquez Raquel , Barrantes-Freer Alonso , Müller Meike , Müller-Decker Karin , Stein Reuven , Tsarfaty Galia , Satchi-Fainaro Ronit , Umansky Viktor , Pukrop Tobias , Erez Neta
Published: April 2023

Supplementary Figure S6: No macrometastases were detected in mice analyzed for blood vessel permeability
Supplementary Figure S4 from Incipient Melanoma Brain Metastases Instigate Astrogliosis and Neuroinflammation
Authors: Schwartz Hila , Blacher Eran , Amer Malak , Livneh Nir , Abramovitz Lilach , Klein Anat , Ben-Shushan Dikla , Soffer Shelly , Blazquez Raquel , Barrantes-Freer Alonso , Müller Meike , Müller-Decker Karin , Stein Reuven , Tsarfaty Galia , Satchi-Fainaro Ronit , Umansky Viktor , Pukrop Tobias , Erez Neta
Published: April 2023

Supplementary Figure S4: Detection and molecular quantification of CTCs
Supplementary Table 1 and Supplementary Figures 1 through 8 from Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon
Authors: Dermadi Denis , Valo Satu , Ollila Saara , Soliymani Rabah , Sipari Nina , Pussila Marjaana , Sarantaus Laura , Linden Jere , Baumann Marc , Nyström Minna
Published: April 2023

Table S1. Composition of the diets. Figure S1. Related to Western diet increases weight and induces neoplastic changes in colon paragraph in the main text. Figure S2. Venn diagrams of proteins detected and identified with two different proteomics platforms: 2D-DIGE and LS-MS. Figure S3. Related to Figure 2. Extended histological analysis of colon crypts. Figure S4. Related to Figure 3. Changes in bile acid transport pathway. Figure S5. Related to Figure 4. Volcano plot of metabolomics analysis of bile acids. Figure S6. Heatmap of comparison between fold changes in protein abundance detected in our study with 2D DIGE and RNAseq data (GSE67342). Figure S7. Network analysis of LC-MS proteomics data at 12 months, combined with metabolomics data showing expression of proteins and concentration of intracellular bile acids in WD mice, supports inactivation of SREBF2 and HNF4A, both involved in regulation of Asbt transcription. Figure S8. Abundance of MUC2 measured with LC-MS revealed increase of MUC2 in 12m WD group and reduction in 18m WD when compared to control groups.
Supplemental Materials Index from Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis
Authors: Murphy Brendan , Yin Han , Maris John M. , Kolb E. Anders , Gorlick Richard , Reynolds C. Patrick , Kang Min H. , Keir Stephen T. , Kurmasheva Raushan T. , Dvorchik Igor , Wu Jianrong , Billups Catherine A. , Boateng Nana , Smith Malcolm A. , Lock Richard B. , Houghton Peter J.
Published: April 2023

Index of Supplemental materials
Supplemental Figure 1 from Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis
Authors: Murphy Brendan , Yin Han , Maris John M. , Kolb E. Anders , Gorlick Richard , Reynolds C. Patrick , Kang Min H. , Keir Stephen T. , Kurmasheva Raushan T. , Dvorchik Igor , Wu Jianrong , Billups Catherine A. , Boateng Nana , Smith Malcolm A. , Lock Richard B. , Houghton Peter J.
Published: April 2023

Prediction accuracy for ALL models
Supplementary Table S3 from Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma
Authors: Lamy Philippe , Nordentoft Iver , Birkenkamp-Demtröder Karin , Thomsen Mathilde Borg Houlberg , Villesen Palle , Vang Søren , Hedegaard Jakob , Borre Michael , Jensen Jørgen Bjerggaard , Høyer Søren , Pedersen Jakob Skou , Ørntoft Torben F. , Dyrskjøt Lars
Published: April 2023

Allele specific expression (ASE).
Supplementary Table S2 from Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma
Authors: Lamy Philippe , Nordentoft Iver , Birkenkamp-Demtröder Karin , Thomsen Mathilde Borg Houlberg , Villesen Palle , Vang Søren , Hedegaard Jakob , Borre Michael , Jensen Jørgen Bjerggaard , Høyer Søren , Pedersen Jakob Skou , Ørntoft Torben F. , Dyrskjøt Lars
Published: April 2023

Mutations called by MuTect.
Supplementary Methods and References from Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma
Authors: Lamy Philippe , Nordentoft Iver , Birkenkamp-Demtröder Karin , Thomsen Mathilde Borg Houlberg , Villesen Palle , Vang Søren , Hedegaard Jakob , Borre Michael , Jensen Jørgen Bjerggaard , Høyer Søren , Pedersen Jakob Skou , Ørntoft Torben F. , Dyrskjøt Lars
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Table S3 from BET Inhibitors Suppress ALDH Activity by Targeting ALDH1A1 Super-Enhancer in Ovarian Cancer
Authors: Yokoyama Yuhki , Zhu Hengrui , Lee Jeong Heon , Kossenkov Andrew V. , Wu Sherry Y. , Wickramasinghe Jayamanna M. , Yin Xiangfan , Palozola Katherine C. , Gardini Alessandro , Showe Louise C. , Zaret Kenneth S. , Liu Qin , Speicher David , Conejo-Garcia Jose R. , Bradner James E. , Zhang Zhiguo , Sood Anil K. , Ordog Tamas , Bitler Benjamin G. , Zhang Rugang
Published: April 2023

A list of candidate BRD4 binding sites similar to those previously described as super-enhancers.
Supplementary Figure S5 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells
Authors: Kaur Amanpreet , Denisova Oxana V. , Qiao Xi , Jumppanen Mikael , Peuhu Emilia , Ahmed Shafiq U. , Raheem Olayinka , Haapasalo Hannu , Eriksson John , Chalmers Anthony J. , Laakkonen Pirjo , Westermarck Jukka
Published: April 2023

HDAC4 inhibition sensitize GBM cells to kinase inhibitors. Supplementary figure related to Figure 5.
Legends for supplementary figures from Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non–Small Cell Lung Cancers
Authors: Deb Dhruba , Rajaram Satwik , Larsen Jill E. , Dospoy Patrick D. , Marullo Rossella , Li Long Shan , Avila Kimberley , Xue Fengtian , Cerchietti Leandro , Minna John D. , Altschuler Steven J. , Wu Lani F.
Published: April 2023

Legends for the supplementary figures.
Supplementary Figure S3 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells
Authors: Kaur Amanpreet , Denisova Oxana V. , Qiao Xi , Jumppanen Mikael , Peuhu Emilia , Ahmed Shafiq U. , Raheem Olayinka , Haapasalo Hannu , Eriksson John , Chalmers Anthony J. , Laakkonen Pirjo , Westermarck Jukka
Published: April 2023

Reactivation of specific PP2A complexes is required for PME-1 depletion-mediated synthetic lethality. Supplementary figure related to Figure 3.
Supplementary data from CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer
Authors: Wang Dingzhi , Sun Haiyan , Wei Jie , Cen Bo , DuBois Raymond N.
Published: April 2023

Supplementary methods, figures, and figure legends Supplemental Figure S1. gMDSCs in pre-metastatic livers Supplemental Figure S2. The CXCL1-CXCR2 axis is required for formation of pre-metastatic niches and liver metastasis Supplemental Figure S3. The effect of VEGF knockdown on cecal tumor growth and the VEGFR levels on macrophages
Supplementary Information from HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors
Authors: Medon Mikolaj , Vidacs Eva , Vervoort Stephin J , Li Jason , Jenkins Misty R. , Ramsbottom Kelly M. , Trapani Joseph A. , Smyth Mark J. , Darcy Phillip K. , Atadja Peter W. , Henderson Michael A. , Johnstone Ricky W. , Haynes Nicole M.
Published: April 2023

Supplemental Figure Legend, Supplementary Figure 1 Flow cytometric analysis of HER2 expression on AU565pv and BT474 tumor cells; Supplementary Figure 2 Co-treatment with panobinostat and trastuzumab does not alter splenic NK cell activation/maturation status or frequency in AU565pv tumor-bearing SCID mice; Supplementary Figure 3 Panobinostat-mediated enrichment of interferon-gamma response and chemokine associated gene signatures; Supplementary Figure 4 SCID mice bearing AU565pv tumors were treated with PBS/DMSO (Vehicle), DMSO/trastuzumab (10 mg/kg), PBS/panobinostat (15 mg/kg) or panobinostat and trastuzumab (combination); Supplementary Figure 5 Panobinostat treatment modulates expression of both the activation receptor CD69 and Fc-receptors CD16/32 on IL-2 activated mouse and human NK cells; Supplementary Figure 6 Co-treatment of panobinostat and trastuzumab attenuates HER2 expression in BT474 and BT474-MyrAKT tumor cells; Supplementary Figure 7 Panobinostat is more effective than doxorubicin at supporting the curative activity of anti-HER2 therapy in Her2/neu transgenic mice bearing established rHER2+ H2N113 mammary tumors; Supplementary Figure 8 Rejection of Bcl-2 over-expressing AU565pv tumors in SCID mice treated with the combination therapy.
Supplementary Figure Legends from Assessing Immune-Related Adverse Events of Efficacious Combination Immunotherapies in Preclinical Models of Cancer
Authors: Liu Jing , Blake Stephen J. , Harjunpää Heidi , Fairfax Kirsten A. , Yong Michelle C.R. , Allen Stacey , Kohrt Holbrook E. , Takeda Kazuyoshi , Smyth Mark J. , Teng Michele W.L.
Published: April 2023

Legend for Supplementary Figures S1-S10.
Supplementary Tables 1 through 4 from Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells
Authors: Kang Dong Woo , Lee Shin Wha , Hwang Won Chan , Lee Bo Hui , Choi Yong-Seok , Suh Young-Ah , Choi Kang-Yell , Min Do Sik
Published: April 2023

Supplementary Table S1. Primer sets for Q-RT-PCR. Supplementary Table S2. Sequences of the promoter-specific primers used in ChIP assay Supplementary Table S3. Primer sets for mice genotype Supplementary Table S4. Factors of multivariates variables, gender, age, organ, tumor stage, and the protein pairs using Cox's proportional hazards model.
Supplementary Table S3: Table shows the pathway deregulated in OUH and TCGA cohort. from The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma
Authors: Sandhu Vandana , Wedge David C. , Bowitz Lothe Inger Marie , Labori Knut Jørgen , Dentro Stefan C. , Buanes Trond , Skrede Martina L. , Dalsgaard Astrid M. , Munthe Else , Myklebost Ola , Lingjærde Ole Christian , Børresen-Dale Anne-Lise , Ikdahl Tone , Van Loo Peter , Nord Silje , Kure Elin H.
Published: April 2023

Table shows the pathway deregulated in OUH and TCGA cohort.
Supplementary Figure Legends from Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells
Authors: Kang Dong Woo , Lee Shin Wha , Hwang Won Chan , Lee Bo Hui , Choi Yong-Seok , Suh Young-Ah , Choi Kang-Yell , Min Do Sik
Published: April 2023

Legend for supplementary figures.
Supplementary Figures from Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States
Authors: Pedersen Elisabeth A. , Menon Rajasree , Bailey Kelly M. , Thomas Dafydd G. , Van Noord Raelene A. , Tran Jenny , Wang Hongwei , Qu Ping Ping , Hoering Antje , Fearon Eric R. , Chugh Rashmi , Lawlor Elizabeth R.
Published: April 2023

Supplemental Figure S1. RNAseq identifies a Ewing sarcoma-specific Wnt/beta-catenin transcriptional response Supplemental Figure S2. GSEA shows inverse relationship between Wnt/beta-catenin and EWS/ETS transcriptional targets Supplemental Figure S3. EWS/FLI1 inhibits Wnt-activation and Wnt-stimulated cells activate microtubule genes Supplemental Figure S4. Activation of Wnt/beta-catenin results in cell spreading and increased tumor cell size Supplemental Figure S5. TNC is repressed by EWS/FLI1 and high- level expression of TNC promotes anchorage-independent growth
Supplementary figure legends from The WASF3–NCKAP1–CYFIP1 Complex Is Essential for Breast Cancer Metastasis
Authors: Teng Yong , Qin Haiyan , Bahassan Abdulaziz , Bendzunas N. George , Kennedy Eileen J. , Cowell John K.
Published: April 2023

legends to supplementary figures in a single file.
Supplementary figure 6 from The WASF3–NCKAP1–CYFIP1 Complex Is Essential for Breast Cancer Metastasis
Authors: Teng Yong , Qin Haiyan , Bahassan Abdulaziz , Bendzunas N. George , Kennedy Eileen J. , Cowell John K.
Published: April 2023

crystal structure of WASF3-CYFIP1-NCKAP1 complex
Supplementary Figures and Tables from Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells
Authors: Kanlikilicer Pinar , Rashed Mohammed H. , Bayraktar Recep , Mitra Rahul , Ivan Cristina , Aslan Burcu , Zhang Xinna , Filant Justyna , Silva Andreia M. , Rodriguez-Aguayo Cristian , Bayraktar Emine , Pichler Martin , Ozpolat Bulent , Calin George A. , Sood Anil K. , Lopez-Berestein Gabriel
Published: April 2023

Supplementary Data includes Supplementary Figures 1-6 and Supplementary Tables 1-3. Supplementary Figure 1 shows microscopic images for the characterization of exosomes. Supplementary Figure 2 shows the qPCR results of miR-6126 overexpression in miR-6126 mimic treated ovarian cancer cells (HeyA8, HeyA8-MDR, Skkov3-ip1, SKOV3-TR) Supplementary Figure 3 shows western blotting and qPCR results that shows the ingibition of Integrin beta-1 expression at protein and mRNA level upon miR-6126 mimic treatment. Supplementary Figure 4 shows the size distribution graphs of exosomes isolated from CTL mimic, miR-6126 mimic , CTL inhibitor, miR-6126 inhibitor treated SKOV3-IP1 cells. Supplementary Figure 5 shows ITGB1 mRNA levels in different ovarian cancer exosomes. Supplementary Figure 6 shows in vivo down regulation of ITGB1. Supplementary Table 1 shows demographic information of ovarian cancer patients whose tissue samples used in quantification of miR-6126 expression. Supplementary Table 2 shows raw microarray data for miR-6126 Supplementary Table 3 shows z-score values for miR-6126 for each exosome and cell sample.
Supplementary Methods and legends from Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma
Authors: Jariwala Nidhi , Rajasekaran Devaraja , Mendoza Rachel G. , Shen Xue-Ning , Siddiq Ayesha , Akiel Maaged A. , Robertson Chadia L. , Subler Mark A. , Windle Jolene J. , Fisher Paul B. , Sanyal Arun J. , Sarkar Devanand
Published: April 2023

File contains text of supplementary methods and figure legends
Figure S1 from BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses
Authors: Althubiti Mohammad , Rada Miran , Samuel Jesvin , Escorsa Josep M. , Najeeb Hishyar , Lee Koon-Guan , Lam Kong-Peng , Jones George D.D. , Barlev Nickolai A. , Macip Salvador
Published: April 2023

Supplementary Figure 1.p53 expression and phosphorylation.
Supplementary Table S8 from JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers
Authors: Facompre Nicole D. , Harmeyer Kayla M. , Sole Xavier , Kabraji Sheheryar , Belden Zachary , Sahu Varun , Whelan Kelly , Tanaka Koji , Weinstein Gregory S. , Montone Kathleen T. , Roesch Alexander , Gimotty Phyllis A. , Herlyn Meenhard , Rustgi Anil K. , Nakagawa Hiroshi , Ramaswamy Sridhar , Basu Devraj
Published: April 2023

Top (most significant) 200 up-regulated gene sets enriched in G0-like cells vs. bulk population.
Supplementary Table S1-S5 from Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition
Authors: Hwang Wen , Chiu Yu-Fan , Kuo Ming-Han , Lee Kuan-Lin , Lee An-Chun , Yu Chia-Cherng , Chang Junn-Liang , Huang Wen-Chien , Hsiao Shih-Hsin , Lin Sey-En , Chou Yu-Ting
Published: April 2023

'Table S1. Q-PCR primer and probe sequences for quantifying gene expression; Table S2. Q-PCR primer and probe sequences for quantifying gene amplification; Table S3. Antibodies for Western blot; Table S4. Antibodies for immunofluorescence; Table S5. Gene expression profiling data from the public domain used in this study.'
Supplementary Table S6 from JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers
Authors: Facompre Nicole D. , Harmeyer Kayla M. , Sole Xavier , Kabraji Sheheryar , Belden Zachary , Sahu Varun , Whelan Kelly , Tanaka Koji , Weinstein Gregory S. , Montone Kathleen T. , Roesch Alexander , Gimotty Phyllis A. , Herlyn Meenhard , Rustgi Anil K. , Nakagawa Hiroshi , Ramaswamy Sridhar , Basu Devraj
Published: April 2023

Differentially expressed genes in JARID1Bhigh vs. bulk LNT14 cells.
Supplementary Materials and Methods from Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition
Authors: Hwang Wen , Chiu Yu-Fan , Kuo Ming-Han , Lee Kuan-Lin , Lee An-Chun , Yu Chia-Cherng , Chang Junn-Liang , Huang Wen-Chien , Hsiao Shih-Hsin , Lin Sey-En , Chou Yu-Ting
Published: April 2023

'Establishment of gefitinib-resistant cell lines; RNA extraction and quantitative real-time polymerase chain reaction (Q-PCR); Genomic DNA extraction and DNA sequencing; AlamarBlue® viability assay; Xenograft tumorigenicity assay; RNA In Situ Hybridization; Immunomagnetic reduction (IMR) assay.'
Figure S1-S16 from Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition
Authors: Hwang Wen , Chiu Yu-Fan , Kuo Ming-Han , Lee Kuan-Lin , Lee An-Chun , Yu Chia-Cherng , Chang Junn-Liang , Huang Wen-Chien , Hsiao Shih-Hsin , Lin Sey-En , Chou Yu-Ting
Published: April 2023

'Figure S1. Lack of T790M and amplification of MET in HCC827GR cells; Figure S2. VGF-expressing cells are resistant to rociletinib; Figure S3. VGF expression in neuroendocrine carcinoma and EGFR-TKI resistant cells; Figure S4. VGF is expressed in the independently selected EGFR-TKI resistant HCC827 pool; Figure S5. Correlation of VGF levels with EGFR-TKI resistance and EMT in EGFR-TKI selected single cell clones; Figure S6. Effect of VGF expression on cell survival; Figure S7. VGF is highly expressed in small cell lung cancer; Figure S8. VGF is highly expressed in large cell neuroendocrine carcinoma; Figure S9. Correlation of VGF, CEACAM6, SYP, and CHGB expression levels with IC50 values of gefitinib in EGFR-mutated lung cancer cell lines; Figure S10. EGFR-TKI resistance in H1975 cells expressing differential VGF levels; Figure S11. VGF-TWIST1 signaling encourages EGFR-TKI resistance; Figure S12. Effect of conditioned medium from VGF expressing cells on low serum-mediated growth; Figure S13. Effect of doxycycline alone on tumor cell growth in vitro and in vivo; Figure S14. Correlation of VGF with EMT markers in lung adenocarcinoma; Figure S15. Correlation of neuroendocrine markers or TWIST1 with survival in lung adenocarcinoma; Figure S16. Correlation of neuroendocrine markers or VGF-TWIST1 signature with survival in EGFR-mutated lung adenocarcinoma.'
Supplementary Table S3 from JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers
Authors: Facompre Nicole D. , Harmeyer Kayla M. , Sole Xavier , Kabraji Sheheryar , Belden Zachary , Sahu Varun , Whelan Kelly , Tanaka Koji , Weinstein Gregory S. , Montone Kathleen T. , Roesch Alexander , Gimotty Phyllis A. , Herlyn Meenhard , Rustgi Anil K. , Nakagawa Hiroshi , Ramaswamy Sridhar , Basu Devraj
Published: April 2023

Clinical and pathologic traits of human squamous cell carcinomas and their derivatives used in this study.
S-Figure-4 from Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
Authors: Liu Yan , Li Yuyang , Wang Xiaoen , Liu Feiyang , Gao Peng , Quinn Max M. , Li Fei , Merlino Ashley A. , Benes Cyril , Liu Qingsong , Gray Nathanael S. , Wong Kwok-Kin
Published: April 2023

In vitro combination treatment of Lkb1-null cell lines with AZD7762 plus the indicated other drug