bluuebunny/crossref_metadata_2025 huggingface dataset:
MEDICAL-SOCIAL PORTRAIT OF THE FEMALE PATIENT SUFFERING FROM THE ONCOLOGICAL DISEASE
Authors: Goleva O. P , Prudnikova O. N , Vyushkov D. M , Leonov O. V , Tasova Zulfiya B.
Published: September 2020

In the article there are presented results of the analysis of the questionnaire survey of 236 respondents, the executed survey according to specially developed questionnaire has been directed to the study of medico-social features of patients of the gynecologic unit of the Clinical Oncologic Dispensary. The typical patient was established to be typical urban resident aged of 52.6 ± 0.6 years, who has a college education (the highest or specialized secondary), satisfactory living conditions, married and equal smooth relationships in a family. On the one hand, the most part of women (76.3%) were quite active physically during the day (are involved in the work on a personal plot, the private house or played sports), from the other side - 33,8% of respondents had excess weight (25 < IMT < 30). 82.2% of women indicated that they had financial difficulties. The presence of such a harmful habit as smoking was demonstrated by 16.9% of respondents, however, the majority of women (56.7%) do not drink alcohol at all. The obstetric and gynecologic history included menses in the period from 12 to 14 years (79.3%), the most part of the interviewed cases did not show disorders in menses of various character. Average age of the beginning of sex life accounted for 19.5 ± 0.12 years, the average number of pregnancies per 1 woman amounted to 3.4 ± 0.12. Among the leading somatic diseases there were indicated diseases of the circulatory system (27.5%), digestive tract (19,4%), the musculoskeletal system (14%), urinary tract (9.9%) and pathology of respiratory organs (7.5%). The hereditary burdened malignant process took place in 42.6% of respondents, at the same time in most of respondents (51.3%) the disease was registered for the first time.
TARGETED THERAPY OF NON-SMALL-CELL LUNG CANCER PATIENTS: MOST COMMON ADVERSE EVENTS AND METHODS OF THEIR CORRECTIONS
Authors: Reutova Elena V. , Laktionov K. P , Ardzinba M. S
Published: September 2020

Major advances in the treatment of non-small-cell lung cancer (NSCLC) patients are associated with the targeted therapy. It is both highly effective in the presence of activating mutations in the tumor and generally well-tolerated. Serious adverse events are recorded much less than with chemotherapy. There are significant differences in the toxicity profile. Both early detection and proper and timely correction of complications of targeted therapies are necessary for the successful long-term treatment of metastatic NSCLC patients.
MORBIDITY AND MORTALITY RATE FROM MALIGNANT TUMORS IN CHILDREN IN THE RUSSIAN FEDERATION OVER 2011-2016
Authors: Rykov Maxim Yu.
Published: September 2020

Introduction Planning the medical care management for cancer children is based, inter alia, on epidemiological data: morbidity and mortality rates in children with malignant neoplasms. Material and methods. The data of the public health care executive authorities of the constituent entities of the Russian Federation have been analyzed. These reports included data on morbidity, mortality, one-year mortality rates, and the period of the medical care delivery for children with oncological diseases in subjects. Results. Over past 6 years, the number of primary patients, identified annually (by 2011 - 3230, 2016 - 3875) increased by 20%; the number of patients under observation was increased by 34.8% (2011 - 17,958, 2016 - 24,207). The incidence increased by 9.8%: from 12.2 per 100,000 (0-17 years) in 2011 to 13.4 in 2016. The standardized mortality rate in 2011-2013 was 4 (per 100 thousand. 0-19 years), in 2014-2016 - 3.6 (per 100 thousand. 0-17 years). The one-year mortality rate decreased by 2%: from 10.8% in 2011 to 8.8% in 2016, the number of actively identified patients increased by 1.4% (in 2007 - 3.8%, in 2016 - 5.2%), the one-year mortality rate decreased by 5.9% (2007 - 14.7%, 2016 - 8.8%). Among causes of death the first place was occupied by leukemia, the second one - by tumors of the brain and spinal cord, the third - sarcomas of soft tissues. Conclusion. The noted dynamics demonstrates an increase in the detectability of oncological diseases in children, therefore, it indicates to the improvement of diagnostic methods. Taking into consideration the average world morbidity rate to account of 15 per 100 thousand children, it is possible to forecast a further increase in the incidence (detectability) of up to 4 500 primary patients by 2022. Thus, at present, an annual underreport is about 700(16%) patients. A low percentage of actively identified children shows the insufficient training of primary care physicians (district pediatricians) in pediatric oncology.
EXPERIENCE IN GRANT-MANAGEMENT GAINED BY THE SERVICE OF OPERATIVE INFORMATIONAL SUPPORT FOR RESEARCH AT THE FEDERAL STATE BUDGET INSTITUTION «NATIONAL MEDICAL RESEARCH CENTER OF RADIOLOGY» OF THE HEALTH MINISTRY OF RUSSIAN FEDE-RATION IN 2015-2016
Authors: Kaprin A. D , Savina Nella P. , Starinsky V. V , Maznev V. A
Published: September 2020

This paper describes the work experience gained at the Federal State Budget Institution «National Medical Research Center of Radiology» (FSBI «NMRC of Radiology») of the RF Health Ministry in 2015-2016. Information about 94 grants received by researchers by means of the use of domestic and international information resources stored on electronic and print media is presented. The results of processing and analysis of databases enabled to characterize the personnel activity in branches to receive financial support for research in the areas of medical radiology, radiobiology, radiation epidemiology and oncology as well as to make a decision and highlight problems in funding of projects.
CARDIOVASCULAR COMPLICATIONS OF ANTICANCER THERAPY: CLINICAL FEATURES, DIAGNOSIS, TREATMENT, PREVENTION (PART II)
Authors: Vatutin N. T , Sklyannaya E. V , El-Khatib Mariam A. , Taradin G. G
Published: September 2020

The given review is devoted to the problem of the cardiotoxicity of chemotherapeutic agents. Many of chemotherapeutic agents can cause cardiovascular complications such as left ventricular dysfunction and heart failure development, myocardial ischemia, arterial hypertension, thromboembolism, QT prolongation and arrhythmias. The toxic influence of the most often used chemotherapeutic agents on heart (such as antimetabolites, alkylating agents, platinum compounds, taxanes, vinca alkaloids, monoclonal antibodies, anthracycline antibiotics, topoisomerase and protein kinase inhibitors, immunomodulatory agents and cytokines) has been described. The results of recent studies on etiology, pathogenesis and clinical features of chemotherapy-induced cardiotoxicity were present in the first part of review. The clinical features, diagnosis, treatment and prevention of the cardiotoxicity of chemotherapeutic agents, are described in the second part of the review
THE ROLE OF LYMPHODISSECTION IN THE TREATMENT OF PATIENTS WITH DISSEMINATED OVARIAN CANCER
Authors: Nikogosyan Seda O. , Mamajonov H. I , Levchenko N. E
Published: September 2020

For many years ovarian cancer (OC) has remained the leading cause of mortality from gynecological cancer diseases. The problem of late diagnosis of ovarian cancer remains still unresolved in more than 70% of patients when the diagnosis is established at advanced stages. The standard approach to the treatment of patients is to perform surgical removal of the tumor at the first stage, which often pursues both therapeutic and diagnostic purposes, as it allows performing the disease restaging and assessing its prevalence. To date, the question of the relevance of implementation and the extent of lymph node dissection still remains open. In this regard, in this article, we want to present the available evidence base regarding the use of the performing retroperitoneal lymph node dissection in advanced OC patients.
ASSOCIATION OF MICRORNA EXPRESSION WITH EARLY STAGE OF BREAST CANCER METASTASIS
Authors: Grishina Kristina A. , Pospekhova N. I , Khaylenko V. A , Karpukhin A. V
Published: September 2020

A serious complication of breast cancer is metastasis of tumor cells. The initiation of this process takes place in the nearby lymphatic vessels. To date, the molecular mechanisms of metastasis are not well understood and further research is required. In this regard, the level of miRNA expression can provide information both on the mechanisms of metastasis development and also be a source of markers for the prognosis of metastatic breast cancer. In the present work, according to the literature, we selected four microRNAs (miR-34a, miR-145, miR-125b and miR-222), potentially capable of being associated with metastasis, to study their association with metastasis to lymph nodes at an early stage. The measurement of the expression of four selected miRNAs on 40 paired samples (tumor-norm) was performed using real-time PCR. Frequencies of miR-34a, miR-145, miR-125b, and miR-222 relative to normal tissue were determined for reduced or increased miR-mRNA expression. For a more detailed study of the association of miRNA expression with lymph node metastasis, miR-125b and miR-222 were selected. An association of expression of these two miRNAs was found with the onset of metastasis to the lymph nodes: with the same level of confidence, differences (p = 0.01). Both miRNAs (miR-125b and miR-222) are involved in the metastasis of breast cancer, apparently by influencing the epithelial-mesenchymal transition. They can potentially act as prognostic biomarkers to assess the likelihood of early lymph node metastases in breast cancer.
INFLUENCE OF CHRONIC NEUROGENIC PAIN ON DYNAMICS OF ENDOTHELIN-1 LEVEL AND COMPONENTS OF NO-SYSTEM DURING MELANOMA B16/F10 GROWTH
Authors: Kit O. I , Kotieva I. M , Frantsiyants E. M , Surikova Ekaterina I. , Kaplieva I. V , Bandovkina V. A , Trepitaki L. K , Pogorelova Ju. A
Published: September 2020

Chronic neurogenic pain is a pathogenic factor triggering mechanisms of homeostasis disfunction. As chronic neurogenic pain has been found to affect the biological features of B16/F10 melanoma, the purpose of the study was to determine the levels of endothelin-1 and components of the NO-system in mice during the growth of transplantable B16/F10 melanoma with chronic pain. Methods. The study included 64 female mice. B16/F10 melanoma was transplanted under the skin of the back to animals of the main group 2 weeks after the sciatic nerve ligation. Levels of endothelin-1, NOS-2, NOS-3, L-arginine, citrulline, total nitrite, nitrotyrosine and ADMA were determined by ELISA in the intact skin and in tumor tissues. Results. The dynamics of the studied parameters in tumor growth with and without chronic pain was different. Increased levels of endothelin-1 in the skin and in tumor tissues, stably elevated levels of NO-synthases in the tumor and stably elevated ADMA levels with their decrease by week 3 of the growth were observed in the tumor growth with pain. Conclusions. Chronic pain can contribute to the development of the immune tolerance to tumor antigens in the skin. Conditions are formed that both facilitate the survival of tumor cells and contribute to the further development of melanoma. The dynamics of activity of endothelin-1 and NO systems can promote stimulation of the epithelial-mesenchymal transition, enhance tumor invasion and hemangio- and lymphangiogenesis. Changes in the ADMA inhibitor levels in the tumor growth with chronic pain may indicate a more subtle control of the NO level providing increased melanoma invasiveness.
TARGET THERAPY FOR NON-SMALL CELL LUNG CANCER: COMPLETE RESPONSE TO CRIZOTINIB
Authors: Gordeeva Olga O. , Meshcheryakov A. A , Meshcheryakova N. A
Published: September 2020

In this article we demonstrate a clinical case of young patient with non-small lung cancer with ALK-translocation treated with crizotinib in the first line of therapy. This approach was associated with complete response and acceptable toxicity.
CLINICAL AND MORPHOLOGICAL ASPECTS OF EARLY GASTRIC CANCER AND ASSESSMENT OF PROGNOSTIC FACTORS OF LYMPHOGENIC METASTASIS. (LITERATURE REVIEW)
Authors: Mochalnikova Valeria V. , Perevochsikov A. G
Published: September 2020

To determine the strategy of treatment of EGC in the world today indications for endoscopic resection, proposed by JGCA, is being used. These indications are presented by a number of morphological factors of the EGC, which are correlate with a low level of lymphogenic metastasis. Not all of the medical centers think these indications are safe. There are publications that question the value of these morphological factors, as well as the heterogeneity of the assessment. Also, in addition to the generally recognized indications for ER JGCA, the researchers proposed other algorithms for the selection of EGS patients with low risk of metastasis to perform ER. These methods were developed using regional standards for different ethnic groups and based on different prognostic parameters. In our review, publications in well-known medical journals in English found through computer search were investigated to study the ways of measuring morphological factors and the safety of jgca readings to ER. The search included such terms as “early gastric cancer”, “prognostic factors”,” lymphogenic metastasis”,” endoscopic resection of the PANCREAS “and “absolute and extended indications for endoscopic resection”. The review includs 60 original studies and meta-analyses. In the original studies, the correlation of demographic and morphological characteristics of the tumor and metastatic process were studied, the variants and methods of evaluation of morphological factors were investigated. The meta-analyses researched the correlation between ER and BREAST surgery, compared the level of safety of absolute and relative criteria of endoscopic resection.
Possibilities of differential diagnostics of histologicalforms of primary lung cancer with multi-spiral computed tomography based on artificial intelligence
Authors: Borisenko O. V. , Konovalov V. K. , Lazarev A. F. , Leonov S. L.
Published: September 2020

The problem of lung cancer, visualized including spherical formation of the lung, is becoming increasingly important every year. In the structure of the oncological morbidity of the Russian population among men in 2018, this pathology occupied the leading position 16.9% (in women 4.0%). When analyzing the distribution of patients with lung cancer of various age groups depending on the histotype of the tumor, it was found that in most cases it is adenocarcinoma and squamous lung cancer 85%. MSCT was performed in 342 patients with spherical formation of the lung aged 45 to 80 years using computed tomographs Aquillion 64 and Asteion 4 (Toshiba Medical Systems). Digital analysis of scans was performed using the X-ray + program (Russia, Barnaul), which allows direct sampling of average pixel densities in a tabular form in selected areas of interest from DICOM files for subsequent analysis and statistical processing. The obtained densitometric indicators were received at the inputs of an artificial neural network. The effectiveness of differential diagnosis of histological forms: sensitivity 35.7 + 2.6%, specificity 40.6 + 2.6%, accuracy 76.3 + 2.3%.
Skin melanoma. State of the problem. Review
Authors: Yargunin S. A. , Lazarev A. F.
Published: September 2020

Skin melanoma, being the deadliest form of skin tumor, contributes significantly to cancer mortality and carries a significant and growing public health burden. The incidence of MK is growing steadily throughout the world and is in the nature of a silent epidemic. The critical mortality rate is due to the high metastatic potential of the tumor and the low efficiency of systemic therapy of disseminated forms of the disease. Thanks to a breakthrough in understanding the genetic mechanisms of the appearance of a tumor, the spread and tolerance to treatment, the emergence of a number of targeted and immunological drugs, patients with advanced MK have the hope of prolonging life and even complete cure. However, many diagnostic problems remain; treatment standards; emerging tolerance to therapy. All these questions compel further research into the diagnosis and treatment of this disease.
Positron emission tomography, combined with computed tomography, in resistent lesions of gestational trofoblastic tumors topical diagnostics
Authors: Meshcheriakova L. A. , Maslennikov A. F. , Meshcheriakova N. A. , Pronin A. I. , Chekalova M. A. , Komarov I. G.
Published: September 2020

Introduction. Gestational trophoblastic neoplasias are rare tumors, which consist of about 1% of gynecological cancers. High rate of diagnostic and treatment mistakes leads to late diagnosis, metastatic appearance, resistance to chemotherapy, poor prognosis.
Aim. To demonstrate possibilities of 18F-FDG PET/CT to find resistant lesions of gestational trophoblastic neoplasias.
In the article, we analyze several medical reports to illustrate advantages of 18F-FDG PET/CT for evaluation of resistant gestational trophoblastic neoplasias.
Successful treatment of a chemo-resistant gestational trophoblastic neoplasia using GEMOX. Clinical case
Authors: Meshcheryakov A. A. , Tikhomirova T. E. , Meshcheryakova L. A.
Published: September 2020

Gestational trophoblastic neoplasia is a rare malignancy. The main treatment approach is chemotherapy. Almost all patients can be cured if the diagnosis is established timely and adequate treatment is provided in specialized centers.
In a small part of patients, the tumor progresses despite the use of all standard chemotherapy regimens. Treatment of such patients is difficult for all oncologists, including ones working in specialized centers for the treatment of gestational trophoblastic neoplasia.
This article presents a clinical case of the successful treatment of a patient with multidrug resistant gestational trophoblastic neoplasia using GEMOX regimen.
Analysis of dynamics of total disability rate due to all kinds of traumas in the Russian Federation, the Southern federal district and its subjects in 2009-2014
Authors: Zacharchenko Yuriy I. , Belichenko V. V
Published: September 2020

The Main Bureau of Medical and Social Expertise in Krasnodar Region, Krasnodar, 350000, Russian Federation This article presents analysis of the dynamics of total disability resulting from traumas of all kinds in persons of all ages in the Russian Federation, the Southern Federal District and its subjects during the 6-year period (2009-2014). We revealed the following trends of disability. First of all, the total disability rate decreased in the Russian Federation, the Southern Federal District and its subjects, especially in 2013-2014. The rate of disability was high in middle-aged persons and low in retirement-age persons. The situation was critical and disability rate was high in the Republic of Kalmykia during the whole observation period. We observed low disability in the Astrakhan Region.
Social skills, social networks and psychological well-being of patiens with spinal cord injury
Authors: Boulyubash Irina D. , Bashta O. S
Published: September 2020

The paper presents information concerning the relations between the subjective evaluation of social skills, parameters of the social network and the factors determining psychological well-being ofpatients with spinal cord injury sequellae (SCIS). Thus, one of the focuses of the diagnostic and therapeutic work of a clinical psychologist and psychotherapist in the rehabilitation hospital environment becomes as well a subjective assessment by SCIS patients of their own social skills, as the development of these skills, contributing to the expansion of the social network, which is a resource for the provision ofpsychological wellbeing ofpatients. This testifies not only to the need for correction of the emotional state ofpatients, but also the necessity of specific psychotherapeutic interventions. Such interventions should be aimed at the increasing in the level of communication skills which are useful for the formation of new social relationships and the development of the social network of patients (group forms of training, support groups, chat forums, etc.).
Professional rehabilitation as aspect integration of disabled people in society (on example of the Republic of Mari El)
Authors: Nizova Lyudmila M. , Danilova M. I
Published: September 2020

In the article there is reflected the complex of the most important andfundamental problems ofintegration ofpersons with disabilities into society in two ways: in the theoretical and methodological and analytical-sociological. There are considered institutional aspects of the vocational rehabilitation atfour levels: international, national, regional and local. The study of the views ofdomestic researchers in theoretical and methodological terms has shown problems of the employment ofpersons with disabilities at the regional level to be insufficiently studied up until now. In this connection there were investigated main directions of vocational rehabilitation and integration of disabled people into society thanks to efforts of the Government of the Mari El Republic, Main Bureau of Social and Medical and Expertise of the Republic of Mari El of the Ministry of Labor and Social Protection of the Russian Federation, Department of Labor and Employment ofpopulation of the Republic of Mari El. There is given an estimation of the management and vocational rehabilitation of persons with disabilities in the competitive mesoeconomic labour market. On the basis of monitoring and sociological research of two categories of respondents there were identified priorities, issues andfactors, determined the employment of the disabled persons as a specific population group. The dynamics of active forms of the employment and ranging opinions of respondents allowed to prove the positive role of vocational rehabilitation to expedite the integration processes of disabled persons in society: decline in the number of cases of disability among working age persons surveyedfirstly, reducing the percentage of the gain in the severity ofdisability, the increase in the proportion of the complete rehabilitation among the adult population, the decline in the proportion ofpersons with disabilities among the unemployed people owing to such forms as the organization of specialized job fairs, quotas and creation of work places, referral of disabled persons about self employment. Nevertheless, bearing in mind the persistence of revealed problems, there are proposed author measures on the improvement of the efficacy of the impact of vocational rehabilitation ofpersons with disabilities to accelerate their integration into society, taking into account vectorness, including governing bodies, employers and people with disabilities.
Methods of assessing the health and social status of elderly disabled persons
Authors: Shurgaya Marina A.
Published: September 2020

Execution of documentation is an essential component of the vocational work of experts engaged in the provision of medical and social assistance to the disabled, from the clinical diagnostic to rehabilitation. In the article there is presented the questionnaire of the assessment of health and social status of the elderly disabled person, which allows to reflect the existence of violations of the functions and limitations of life activity, the degree of their severity, needs in certain types of rehabilitation, including with the use of technical means of compensation of disturbedfunctions. This type of documentation allows to reduce (speed up) the time on the execution and to increase the level of the vocational competence of the professionals engaged in medical and social activities as well in health institutions as social protection institutions. With properfilling ofpreprinted forms (layout, template) it will be received medical and social portrait ofa disabled elderly person. Questionnaire can also be used in execution ofscientific research.
Organization of medical rehabilitation of veterans of wars in the context of social support of senior generation in Russia
Authors: Puzin S. N , Memetov S. S , Shurgaya Marina A. , Gal I. G
Published: September 2020

Tasks of the organization of medical care at the present stage lie in the effective and economical use of available health care resources and in the increase of the accessibility and improvement of the quality of medical services. The effectiveness ofprovision of medical services to veterans is based on the systematic monitoring and permanent implementation of health measures aimed on social support of the older generation, along with the maintenance and preservation of health. Emerging trends of population aging as a complex phenomenon of the general civilizational character, reflect at the same time the results of the sequential implementation of legislation in relation to older people in the Russian Federation at Federal, regional and municipal levels. In the current socio-economic conditions on the territory of the Rostov region (RR) there was created and developed and a comprehensive system of rehabilitation ofdisabled persons. In the article there is highlighted the activity of the RR "Hospital for veterans of wars", which in the region is the only the state institution intendedfor the provision of specialized medical care to participants and invalids of the Great Patriotic War and equivalent categories of the population
Dynamics of indices of primary disability of the child population due to diseases of the musculoskeletal system for the period of 2005-2014 in the Altai Territory
Authors: Grigoricheva L. G , Timoshnikova I. V , Goncharenko A. G , Akopyan T. A , Korenyak Nina A. , Samarin B. A
Published: September 2020

The level of disability, along with the indices of the infant mortality rate, morbidity rate, physical development and health demographic processes is a basic index of child health, reflecting the level of economic and social well-being of the country. In the Russian Federation children with disabilities make up, according to various estimates, from 1.5-2.5 to 4.5% of the child population. In the structure of the primary disability of children in the Altai Krai the share of disabled children due to musculoskeletal system pathology in 2005-2014 varied from 13.2% to 26.0%. The level of the primary disability of children due to pathology of a musculoskeletal system increased from 5.7 in 2005 to 6.5 per 10 thousands of the child population in 2014. The gain of the intensive index of the primary disability of children due to pathology of a musculoskeletal system is caused by the increase in the disability level due to diseases of the nervous system (from 2.0 to 4.0 per 10 thousands of the child population) and congenital defects of a musculoskeletal system (with 1.1 to 1.6 per 10 thousands of the child population).
SOME RISK FACTORS FOR THE FORMATION OF CHILDREN’S DISABILITY
Authors: Baranov A. A , Namazova-Baranova L. S , Terletskaya Rimma N. , Antonova E. V
Published: September 2020

The creation of the system of early prophylaxis of children disability and support of families bringing up disabled children and children with limited opportunities of health are among the main priorities of the state social policy of the Russian Federation. The search for literature sources was performed in the Scientific Online Library (eLIBRARY.RU) and PubMed. The dynamics of children’s disability in our country is characterized by the process of stagnation. Among risk factors for the formations of the disability the most discussed are achievements of perinatology leading to the improvement of nursing of prematurely born and small for date newborns, and wide uses of auxiliary reproductive technologies. An important part of all preventive measures aimed at the decline of the genetic load of population is the prenatal and preimplantation diagnosis. It seems appropriate to extend the screening for congenital and hereditary metabolic diseases in neonatal period, including the most common nosological forms of rare illnesses. In the solution of problems of the prevention of the childhood disability a priority should be given to the development of services of family planning, improvement of the antenatal and perinatal care, the preventive work with healthy children with deviations in the development, the development of medical genetic services, implementation of programs of different types of pathology screening.
THE IMPACT OF CONDITIONS AND LIFE STILE OF DISABLED PEOPLE ON THE ASSESSMENT OF THE MEDICAL-SOCIAL ASSISTANCE AND QUALITY OF THE ACCESSIBILITY OF THE ENVIRONMENT
Authors: Alekseev M. A , Moiseeva Karina E. , Kharbedia Sh. D
Published: September 2020

Disability is the one of the topical medico-social problems in the Russian Federation and all over the world. In recent years, our country has developed and implemented a large number of state programs aimed at the adaptation of persons with disabilities for the life in society, one of which is the program «Accessible environment». In the framework of the implementation of the Federal law, persons with disabilities are provided with social housing. In this article on the example of wheelchair users who received social housing and living on the territories of intercity municipality of the village of Pargolovo, Vyborgsky district of the city of Saint Petersburg, in the current socio-economic conditions there is presented the scientific analysis of the impact of the environment and lifestyle on the assessment of health and social care and quality of the accessible environment. This study was executed by the method of the main body by means of the survey of 110 by wheelchair users who received social housing. A study identified main shortcomings of the medico-social assistance to wheelchair users living in the municipality. In the course of the study there were evaluated the quality of environment accessibility for the following indices: openness, adaptability, comfort and security of the social infrastructure, culture, leisure and recreation, as well as skills and the cooperation of the staff of the social infrastructure, culture, leisure, and individuals with disabilities. The analysis of the quality of accessibility of the environment established its compliance with the expected results of the program «Accessible environment».
EFFICIENCY OF THE TREATMENT OF DISABLED PERSONS WITH OBLITERATING ATHEROSCLEROSIS OF ARTERIES OF LOWER EXTREMITIES ACCORDING TO DATA OF THE PROSPECTIVE MEDICAL-SOCIAL RESEARCH
Authors: Kalichava A. Sh , Karasaeva Lyudmila A. , Avdeeva M. V , Luchkevich V. C
Published: September 2020

By the end of the 5-year follow-up period, the limb was succeeded to be preserved in most patients with obliterating atherosclerosis of the vessels of the lower limbs who underwent surgery, both in the aorto-iliac and the femoral-popliteal segment (82,4 and 69,7%). Only in half of patients with obliterating atherosclerosis who underwent surgery on the aorto-iliac or femoral-popliteal segment, the limb was preserved (52,3 and 52,8%). The frequency of amputation after revascularization operations was 2,5 times lower than in cases received the conservative treatment (17,7 and 44,3%; p < 0,05). In the group of conservatively treated patients, a significant and mostly significant restriction of movement was found in 41,6% of patients with obliterating atherosclerosis of the vessels of the lower limbs, while after reconstructive operations, such restrictions were 2,8 times less frequent (41,6 and 14,8%; p < 0,05). After revascularization, the number of people with disabilities in group III was 2,5 times higher than among patients treated conservatively (27,9 and 11,0%; p < 0,05). The main advantage of this type of treatment was a significant reduction in the proportion of patients requiring constant external care than with conservative treatment (11,4 and 33,8%; p < 0,05). Lumbar sympathectomy demonstrated the highest efficacy, because in 43,6% (n = 55) of cases it was performed in the combination with an operation for to revascularization of arteries of lower extremities. Thus, in the study there was demonstrated the higher medical and social effectiveness of the use of surgical methods of treatment compared with conservative ones in the treatment of patients with obliterating atherosclerosis of the vessels of the lower extremities.
THE STUDY OF ADAPTATIONAL CHANGES AGAINST THE BACKGROUND OF THE INTOXICATION INDUCED BY LOW DOSES OF ORGANIC SOLVENTS
Authors: Orujov R. A , Jafarova Rena E.
Published: September 2020

Objectives of the study are the experimental study of the adaptational changes occurring in the animal organism against the background of intoxication induced by low doses of benzene and acetone. Material and methods. There were studied 45 white mice divided into three groups: 1st group was consisted of intact animals; 2nd group included animals exposed to benzene through inhalation at a concentration of 32,6 mg/l; 3rd group included animals exposed to acetone at a concentration of 99,0 mg/l. Animals were poisoned five times in special chambers. Eosinophil, neutrophil and lymphocyte blood count (absolute) was determined according to common procedures. Results and discussion. After general anesthesia the benzene poisoning for the first time resulted in statistically significant reduction of the body temperature by 7,7oC, while after the 5th poisoning procedure this index was reduced slightly. Upon the first poisoning procedure in the animals after their emergence from anesthesia the leukocyte count was reduced by 26,3%, while eosinophil, neutrophil and lymphocyte counts were reduced by 41,3, 87,6 and 62,8% accordingly. The neutrophil to lymphocyte ratio (neutrophil/lymphocyte) was reduced by 39,49%. Before the fifth poisoning procedure, relative to baseline values, the reduction in lymphocyte count amounted to 13,3%; in eosinophil, neutrophil and lymphocyte counts - to 40,0, 1,7 and 13,7% accordingly, while the neutrophil/lymphocyte radio was reduced by 18,9%. After the emergence of the animals from anesthesia of the fifth poisoning procedure, the changes observed in the above-mentioned indices were much less than the changes caused by the first poisoning. Thus, reduction in lymphocyte count amounted to 13,8%; in eosinophil, neutrophil and lymphocyte counts - to 18,3, 4,8 and 17,7% accordingly, while the neutrophil/lymphocyte radio was increased by 16,9%. The results of chronical acetone poisoning of the animals show that after one month from the beginning of the study, the number of neutrophils and monocytes was reduced due to the slight reduction in the quantity of eosinophils, neutrophils and lymphocytes. Conclusion. The shifts in the leukocytic response due to еру repeated exposure to petroleum products through inhalation may be considered as the intensification of protective reaction.
THE PECULIARITIES OF DIAGNOSTICS AND THERAPY OF THE POSTTRAUMATIC STRESS DISORDER IN THE PRACTICE OF A NEUROLOGIST
Authors: Khozhenko Elena V. , Kiparisova E. S , Ekusheva E. V , Puzin M. N , Denishchuk I. S , Pryanikov I. V , Makkaeva S. M , Lepaev Yu. V , Afanas’ev B. G , Dymochka M. A , Tarasova L. A
Published: September 2020

The posttraumatic stress disorder (PTSD) is no longer the pathology proper only to military men both over the world and in our country. At the present time there is observed a gain in PTSD patients. The disease has the negative impact both on the psychical and on somatic state of patients. The untimely and unqualified treatment of PTSD patients contributes to the chronicity of a pathologic process, results in social dysadaptation, prevents the return to the working activity. Doctors of very different specialities, most often neurologists, come into collision with PTSD. The article touches up the most urgent questions concerning PTSD, with the great attention paid to the differentiated diagnostics of the disease and methods of the treatment according to the achievements of the clinical practice. The methods of pharmacotherapy and psychotherapy of PTSD patients have been described on a contemporary level.
THE EPIDEMIOLOGICAL PICTURE OF THE DISABILITY IN VARIOUS DEMOGRAPHIC CONTINGENTS OF THE POPULATION IN THE RUSSIAN FEDERATION IN THE ASPECT OF THE SOCIAL POLICY OF THE STATE
Authors: Puzin S. N , Dymochka M. A , Boitsov S. A , Shurgaya Marina A. , Govorushkina N. S , Krivoruchko Yu. D , Chandirli S. A , Malichenko V. S
Published: September 2020

In 2012 Russia ratified the UN Convention on the Rights of Persons with Disabilities, which provides for the creation of an accessible environment for disabled people, ensuring their rights to work, medical care, education and full participation in public life. This is the fundamental basis on which the social policy of the state in relation to the disabled persons is currently being built. The strategic direction of the social policy of the state is the rehabilitation and habilitation of disabled people, the effectiveness of which depends on the completeness of the study of the epidemiological picture of the spread of disability and the need for various methods of rehabilitation and habilitation in citizens with limited life activity due to violations of the body’s functions. The article presents information characterizing the epidemiological picture of the disability of the population in the Russian Federation, taking into account the main age categories. Data on the total number of disabled people receiving various types of rehabilitation and habilitation services in the Russian Federation are also presented. There are highlighted problematic issues, the solution of which is necessary for the implementation of the social policy of the state.
IMPLEMENTATION MEASURES ON THE DEVELOPMENT OF APPROACHES FOR APPROVAL OF NEW CLASSIFICATIONS AND CRITERIA USED IN THE REALIZATION OF THE MEDICAL AND SOCIAL EXPERTISE OF CHILDREN ON THE BASIS OF THE “MAIN BUREAU OF THE MEDICAL SOCIAL EXPERTIZE IN THE VORONEZH REGION” MINISTRY OF LABOR OF RUSSIA
Authors: Esaulenko Igor E. , Sergeeva O. V , Dmitrenko L. B , Rushanian A. A
Published: September 2020

This article reflects the course and questions of the Pilot project on the approbation of new classifications and criteria used for the implementation of medico-social examination in children. Stages and results of a research described have allowed giving suggestions on the improvement of classifications and criteria according to received results on the basis of institutions of medico-social examination.
“DIFFICULT” ISSUES OF THE MANAGEMENT OF INFLAMMATORY BOWEL DISEASES PATIENTS
Authors: Bakulin I. G , Skalinskaya Mariya I. , Skazyvaeva E. V
Published: September 2020

The article presents “difficult” questions found by physicians in the management of inflammatory bowel diseases (IBD) patients, and also discusses and analyzes data of the Register, established by the North-West Center of the IBD (within the framework of the Federal Register of IBD patients). To date, there are many complex and unresolved issues regarding the management of IBD patients. The situation becomes especially relevant when bearing in mind these diseases start at a young and working age and pose a significant social problem. Data on the IBD prevalence rate and their separate forms vary considerably, but almost all available sources report its gain in recent years. The information displays the prevalence rate of IBD, the forms of the disease, the timing of the diagnosis, both the essence and frequency of complications. The obtained data are compared with the results of other registers. To the actual moment, despite the obvious breakthrough in the development of drugs for the treatment of IBD, not all patients can achieve an optimal response, complete relief of the inflammatory process. The discussion touches upon issues related to the immunogenicity of various genetic engineering biological products and its effect on the efficacy and safety of therapy, as well as the efficacy and safety of biosimilars in the treatment of IBD and the problems associated with predicting the effectiveness and safety of the treatment.
Problems in the diagnosis of dysplastic melanocytic nevi
Authors: Salamova I. V , Mordovtseva Veronica V.
Published: September 2020

The dysplastic nevus is a special type of melanocytic nevi, which is a clinical and morphological marker of increased risk for the development of cutaneous melanoma. Therefore, correct diagnosis and preventive oncological screening of patients in selected risk groups are necessary. Epidemiology and current classification of dysplastic nevi, as well as the problem of clinical and morphological correlation of findings in the differential diagnosis of dysplastic nevi are discussed. Related personal research data are presented.
The choice of rational treatment regiments for different clinical variants of herpes infection
Authors: Olisova O. Yu , Lukashov M. I , Pismennaya Ekaterina V.
Published: September 2020

Depending on the clinical manifestations of patients with herpetic infection was administered differentiated therapy with the use of drugs of Valvir and Panavir. The results of the study showed that appropriate treatment of herpetic infections to spend for differentiated therapy depending on clinical course.
Cutaneous toxic effects of targeted therapy: clinical manifestations and correction
Authors: Shatokhina Eugenia A. , Kotenko K. V , Kruglova L. S
Published: September 2020

Targeted therapy used in oncology today is the most effective, but frequent cutaneous side effects force to reduce dose or interrupt treatment, significantly reducing the anti-tumor effect. The data on the pathogenesis of toxic skin reactions and the most frequent clinical manifestations (papular-pustular reaction, hand-foot syndrome) according to various studies are presented. The basic principles of correction are described. Examples of anticancer drug doses correlation and severity of skin reactions are presented.
Biologically false positive serologic reactions for syphilis in patients with benign uterus tumors
Authors: Khamaganova Irina V. , Malyarenko E. N , Vasilieva A. Yu , Melnichenko O. O , Modnova A. G
Published: September 2020

The mechanism of formation of active and chronic false positive reactions serologic syphilis tests is described. Spontaneous negativation of acute false positive serologic reactions develops in 6 months. Chronic false positive serologic reactions persist for a long time, sometimes during the whole life time. Chronic false positive serologic reactions for syphilis are the diagnostic criteria for systemic lupus. Chronic false positive serologic reactions before and during the evaluation of clinical symptoms in other connective tissue diseases, endocrinologic, oncologic pathology are described. The Hughes ’syndrome is the most often cause of false positive serologic syphilis tests. 3 cases of false positive serologic syphilis tests in patients with benign uterus tumors are presented.
Microarray comparative analysis of melanoma microRNA depending on the tissue fixation method
Authors: Komina A. V , Palkina N. V , Aksenenko M. B , Ruksha Tatyana G.
Published: September 2020

Cutaneous melanoma is the most aggressive form of skin cancer characterized by rapid progression, invasiveness and low survival rates. This explains the importance of optimization of early detection of this tumor. At the present time molecular and genetic methods of cancer investigation are broadly used. One of such methods is microarray that allows to analyze the expression of thousands genes in the single cell. However, this method makes high demands on the quality of samples and research procedure. Today the most common approach for tumor tissue preservation is formalin fixation followed paraffin embedding. This procedure is broadly used in clinical medicine but may affect the structure and availability of nucleic acids of the study sample. The present investigation was done to evaluate the effect of melanoma tissue fixation on the result of microRNA expression analysis by microarray. In this regard, we made comparative study of microRNA expression in melanoma samples fixed in formaldehyde and RNase inhibitor reagent based on ammonium sulfate solution. It has been shown that fixation by formalin as compared to ammonium salts based RNase inhibiting fixator alters the level of 454 microRNAs. Some miRNAs among them are playing an important role in the melanoma progression. Thus, molecular studies of skin tissues by microarray requires more thorough standardization of sample fixation methods or using of special RNA stabilizing solutions. The application of the formalin fixation method to preserve tissue for miRNA expression analysis requires further study.
Prospects of correction of endotoxemia and metabolic syndrome comorbid with allergic dermatitis
Authors: Snarskaya Elena S. , Arsentiev N. S
Published: September 2020

Endotoxin of Gram-negative bacteria of the digestive tract, which has a high degree of toxicity to humans, is considered today as a factor in inducing allergic development and formation of combinedforms of atopic dermatitis (AD), is capable of a more severe disease. Increasing the level of endotoxin leads to the development of endogenous intoxication syndrome (EIS) that accompanies the disease, providing a damaging effect on the tissue and determining the prognosis of AD. At SEI complex metabolic disorders is forming that leads not only to a decrease in the volume of organs of the immune system, increase the permeability of natural barriers, but also to a defect interaction of its individual effector units. Excretion of endogenous and exogenous stimuli from the body at allergic dermatosis prevents the formation of secondary immune deficiency and the further development of the pathological process of the skin, contributing to its stabilization and sustainable long-term remission. Application of detoxifying drug “Eubikor” and general aerocryotherapy at atopic dermatitis leads to more intense reduction of SCORAD, reduces the frequency of exacerbations and increase duration of remission. Method of aerocryotherapy was used to stimulate the mechanisms of activation of metabolism and regeneration of damaged tissues. Clinical experience of “Eubikor” and aerocryotherapy rate in patients with atopic dermatitis is presented.
Grover's disease
Authors: Karaseva Yu. V , Smykova Anastasia N. , Voloshin V. V
Published: September 2020

A review of the etiology, pathogenesis, clinical manifestations and histological characteristics of a rare dermatosis - Grover’s disease is presented. The difficulty of histopathology differential diagnosis of this disease with Darier’s disease andfamilial benign pemphigus Guzhero-Hailey-Hailey is described. The clinical case of Grover’s disease in 87 year old man is presented.
Podvisotskaya O.N. the first academician dermatologist since the moment of establishment of the AMS USSR
Authors: Stochik A. A , Kryazheva S. S
Published: September 2020

Olga Nikolaevna Podvisotskaya (1884-1958) made her way up from the laboratory assistant at the Clinic of Dermal and Venereal Diseases at the St. Petersburg Women’s Medical Institute to the first dermatologist academician at the Academy of Medical Sciences of the USSR. She is one of the leaders of the domestic dermatology of the mid 20th century and the creator of a new school of dermatology, based on pathophysiological researches. O.N. Podvisotskaya is the author of fascinating researches on blastomycosis, chromoblastomycosis, epidermophytia (acute trichophytia of Podvisotskaya), onychomycosis, tuberculosis. She is known as the founder of the Leningrad Lupus Sanatorium. At this time the process of formation of the Academy of Medical Sciences as a standalone structure, designed to put together the practical and theoretical sciences in the country has been evolving. One of the complex phases in this process was the foundation of All Union Institute of Experimental Medicine (AUIEM) and its further reorganisational changes. O.N. Podvisotskaya was taking most active part in the activities of the AUIEM and later - at the AMS after becoming the academician, since the moment of foundation of the Academy of Medical Sciences in 1944.