bluuebunny/crossref_metadata_2025 huggingface dataset:
TYRO Protein Tyrosine Kinase-binding Protein Predicts Favorable Overall Survival in Osteosarcoma and Correlates With Antitumor Immunity
Authors: Xu Hai-ru , Chen Jun-jie , Shen Jin-ming , Ding Wei-hang , Chen Jie
Published: January 2022

Objective: To explore the prognostic significance and underlying mechanism of TYRO protein tyrosine kinase-binding protein (TYROBP) in osteosarcoma. Methods: Firstly, the expression of TYROBP was analyzed using the t-test. The Kaplan-Meier plotter analysis and a receiver operating characteristic (ROC) curve were performed to evaluate the influence of TYROBP on overall survival (OS). Further, Cox regression analysis was conducted to predict the independent prognostic factors for OS of osteosarcoma patients, and a nomogram was constructed. Then, the relationship between TYROBP and clinicopathological characteristics was determined using statistical methods. Enrichment analyses were conducted to evaluate the biological functions of TYROBP. Finally, ESTIMATE algorithm was used to assess the association of TYROBP with immune cell infiltration. Results: TYROBP was significantly increased in osteosarcoma (all P <0.001). However, the high expression of TYROBP was related to better OS of osteosarcoma patients. Cox regression analysis showed that TYROBP was an independent prognostic factor for predicting OS (P =0.005), especially in patients with male sex, age <18 years, metastasis, and tumor site leg/foot (all P <0.05). Besides, TYROBP mRNA expression was significantly associated with tumor site (P <0.01) but had no remarkable relationship with age, gender, and metastasis status (all P>0.05). Functional annotation and GSEA revealed that TYROBP was mainly involved in immune-related pathways. Importantly, TYROBP positively correlated with immune scores (P <0.001, r=0.87). Conclusions: TYROBP served as an independent prognostic biomarker for OS in osteosarcoma. High TYROBP expression might prolong the survival of osteosarcoma patients mainly through promoting antitumor immunity.
Prediction of Shear Strength of UHPC Beam with Small Shear Span to Depth Ratios Based on Modified MCFT
Authors: Zhou Linyun , Wan Shui
Published: January 2022

Ultra-high performance concrete (UHPC) has been gradually used in structure engineering due to its excellent mechanical performance, however, predicting the shear capacity of the UHPC beams is still a challenge, especially for the beams with small shear span to depth ratios. To address this issue, this paper devotes to developing a rational model to predict the shear capacity of the UHPC beams with stirrups based on the modified compression field theory (MCFT) and plastic theory. The shear force will be balanced by the stirrups, matrix, fibers and shear compression zone. The contribution of stirrups, matrix and fibers on shear capacity can be predicted by MCFT, and the contribution of compression zone is determined based on plastic theory. 12 UHPC beams was designed and tested to validate the proposed model. It can be found that the predictions agree well with test results, while the current design codes, including SETRA-AFGC and SIA, give overly conservative values for UHPC beams when the shear to span is less than 2.5.
Gastrointestinal Helminth Parasites of Wild Ungulates In Hirpora Wildlife Sanctuary, Kashmir, India
Authors: Bhat Rouf Ahmad , Tak Hidayatullah , Bhat Bilal A. , Ahmad Riyaz , Dar Jahangir Ahmad
Published: January 2022

Parasitic infection represents an emerging threat to wild ungulates and a challenge to their management. Although a lot of work has been carried out on helminth parasitic infestation of domestic ungulates of Kashmir but the data pertaining to this aspect of wild ungulates has being ignored. The study on gastrointestinal helminth parasitic infestation of wild ungulates was carried out during post livestock grazing period (November to May) of 2018/2019 in Hirpora Wildlife sanctuary (HWLS) to fill the gap in the existing literature. During the study fresh faecal samples of musk deer Moschus sp.(n=44) and markhor Capra falconeri (n=41)were collected and examined qualitatively and quantitatively for gastrointestinal helminth parasites. A total of seven helminth parasites were recorded which are arranged in the descending order of their overall prevalence as Haemonchus spp. (44.70%),Nematodirus spp. (40%), Trichuris spp. (37.64%), Strongyloides spp. (34.11%)Trichostrongylus spp. (28.23%),Monieziaspp. (23.52%) and Fasciola spp. (20%). The mean EPG (eggs per gram) of different parasites showed a considerable variation in both the wild ungulates. The highest mean EPGwas that of Haemonchus spp. and the lowest mean EPG was that of Fasciola spp. in both hosts. A statistically significant difference was observed in the mean EPG of different parasites among two wild hosts (t=3.606, p=0.01).
Giant magnon spin conductivity approaching the two-dimensional transport regime in ultrathin yttrium iron garnet films
Authors: Wei Xiangyang , Santos Obed Alves , Lusero Cristhian Humberto Sumba , Bauer Gerrit , Youssef Jamal Ben , Wees Bart van
Published: January 2022

Conductivities are key material parameters that govern various types of transport (electronic charge, spin, heat etc.)
driven by thermodynamic forces. Magnons, the elementary excitations of the
magnetic order, flow under the gradient of a magnon chemical
potential in proportion to a magnon (spin)
conductivity σm. The magnetic insulator yttrium iron
garnet (YIG) is the material of choice for efficient magnon spin transport. Here we
report an unexpected giant σm in record-thin YIG films
with thicknesses down to 3.7 nm when the number of occupied two-dimensional (2D) subbands is
reduced from a large number to a few, which corresponds to a transition from 3D to 2D magnon transport. We extract a 2D spin conductivity (≈1 S) at room temperature, comparable to the (electronic) spin conductivity of the high-mobility two-dimensional
electron gas in GaAs quantum wells at millikelvin temperatures.
Such high conductivities offer unique opportunities to develop low-dissipation magnon-based
spintronic devices.
Study On The Application of Preoperative Three-Dimensional CT Angiography of Perigastric Arteries In Laparoscopic Radical Gastrectomy
Authors: Liu Peng , Yu Wenbin , Wei Meng , Sun Danping , Zhong Xin , Ouyang Jun , Liang Yize
Published: January 2022

Objection: To investigate the clinical value and significance of preoperative three-dimensional computerized tomography angiography (CTA) in laparoscopic radical gastrectomy for gastric cancer.Methods: The clinical data were analyzed retrospectively from 214 gastric cancer patients. We grouped according to whether to perform CTA. The gastric peripheral artery was classified according to CTA images of patients in the CTA group, and we compared and analyzed the difference of the data between the two groups.Results: The celiac trunk was classified according to Adachi classification: Type I (118/125, 94.4%),Type II (3/125, 2.4%),Type III (0/125, 0%),Type IV (1/125, 0.8%),Type V (2/125, 1.6%),Type VI (1/125, 0.8%).Hepatic artery classification was performed according to Hiatt classification standard:Type I (102/125, 81.6％),Type II (9/125, 7.2%),Type III (6/125, 4.8%),Type IV (2/125, 1.6%),Type V (3/125, 2.4%),Type VI (0, 0%),Others (3/125, 2.4%).And this study combined vascular anatomy and clinical surgical risk to establish a new splenic artery classification model. It was found that the operation time and estimated blood loss in the CTA group were significantly lower than those in the non-CTA group. In addition, the blood loss in the CTA group combined with ICG (Indocyanine Green) labeled fluorescence laparoscopy was significantly less than that in the group without ICG labeled. Conclusion: Preoperative CTA can objectively evaluate the vascular course and variation of patients, and then avoid the risk of operation, especially in combination with ICG labeled fluorescence laparoscopy, can further improve the quality of operation.
Assessment of factors affecting flicker ERGs recorded with RETeval from data obtained from health checkup screening
Authors: Inooka Taiga , Kominami Taro , Yasuda Shunsuke , Koyanagi Yoshito , Ota Junya , Okado Satoshi , Ito Yasuki , Terasaki Hiroko , Nishiguchi Koji M. , Ueno Shinji
Published: January 2022

The purpose of this study was to determine the ocular, sex- and age-specific, anthropometric, and hematologic factors that affect the implicit times and amplitudes of the flicker ERGs recorded with the RETeval system from individuals 40- to 89-years-of-age. Flicker ERGs were recorded with the RETeval system from 330 individuals who had normal fundus and OCT images. Univariate and multivariate regression analyses were performed to identify factors associated with the implicit times and amplitudes of the RETeval flicker ERGs. Univariate regression analyses showed significant correlations between the implicit times and the BCVA, age, axial length, blood sugar level, and BUN in both eyes. Multivariate regression analyses identified age and axial length as two independent factors that were significantly correlated with the implicit times of the RETeval flicker ERGs. Univariate regression analyses also showed significant correlations between the amplitudes and age, platelet count, HDL level, and creatinine level in both eyes. However, smoking habits, body mass index, and blood pressure were not correlated with the RETeval flicker ERGs. We conclude that age and some ophthalmologic and hematologic findings except for anthropometric findings were suggested to significantly affect the measurements of the RETeval flicker ERGs.
Development of Plant-Mediated Silver Nanoparticles & Their Pharmacological Evaluation
Authors: Kalakotla Shanker , P Geetha , Banu Ahmadi , Shaik Shamshe
Published: January 2022

Diabetes is among the most common debilitating and non-transferable diseases on the planet. The idea of using nanoparticles as a drug to treat diabetes mellitus seems intriguing. The Ag nanoparticles (Ag NPs) were effectively produced utilizing Moringa olifera (family: Moringaceae) plant extract employing a simple, cheaper, faster, and environmentally friendly green synthesis process. The antidiabetic effect of the produced Ag NPs was also tested in vivo. In the presence of plant extract, silver nitrate was converted to silver ions (Ag). XRD, FTIR, UV, XPS, and HRTEM studies characterize the formed Ag NPs. Ag NPs that have been biosynthesized, crystal nature was confirmed through XRD analysis and confirmed by UV-visible spectroscopy. FT-IR spectra were used to verify the presence of various functional groups in the biomolecules, forming and stabilizing the nanoparticles. The size of the NPS was in the range of 20-40 nm determined by HRTEM. The induction of diabetes using STZ showed increased blood glucose, cholesterol, triglycerides, LDL, VLDL, massive loss in body weight. These changes were reversed following the treatment of diabetic rats for 28 days and showed significant inhibition (p < 0.001) at a dose range of 0.2 mg/kg leaf extract and 0.2 mg/kg Ag NPs compared with the extract-treated group. These obtained results suggested that plant-mediated Ag NPs have shown promising antidiabetic and anti-hyperlipidemic activity compared to the crude extract.
Dissociation Mechanics and Stability of Type a Botulinum Neurotoxin Complex by Means of Biophysical Evaluation
Authors: Hada Shavron , Lee Jae Chul , Lee Eun Chae , Ji Sunkyong , Nam Jeong Sun , Yun Bum Jin , Na Dong Hee , Kim Nam Ah , Jeong Seong Hoon
Published: January 2022

Biophysical characterization of type A botulinum neurotoxin (BoNT/A) complex along with its thermodynamic stability was assessed through a combination of various methods. BoNT/A exists as large complexes in association with neurotoxin associated proteins (NAPs). To evaluate its biophysical behavior, size-exclusion chromatography (SEC), multi-angled light scattering (MALS), enzyme linked immunosorbent assay (ELISA), and dynamic light scattering (DLS) were utilized. Initially, a single peak (peak 1) of SEC was observed at pH 6.0, and an additional peak (peak 2) appeared at pH 7.4 with a decrement of peak 1. Through MALS and ELISA, the peak 2 was determined to be BoNT/A dissociated from its complex. The dissociation was accelerated by time and temperature. At 37°C, dissociated BoNT/A self-associated at pH 7.4 in the presence of polysorbate 20. On the other hand, the dissociation was partly reversible when titrated back to pH 6.0. Overall, BoNT/A was more stable when associated with NAPs at pH 6.0 compared to its dissociated state at pH 7.4. The conventional analytical methods could be utilized to relatively quantify its amount in different formulations.
Computer Modeling of Carotid Endarterectomy With the Different Shape Patches and Prediction of the Atherosclerotic
Authors: Borisov Vladimir Geraldovich , Zakharov Yuri Nikolaevich , Kazantsev Anton Nilolaevich , Korotkikh Alexander Vladimirovich , Shokin Yuri Ivanovich , Evtushenko Alexei Valer’evich , Barbarash Leonid Semenovich , Onishchenko Pavel Sergeevich , Klyshnikov Kirill Yur’evich , Ovcharenko Evgeniy A.
Published: January 2022

Objective: The article describes a method for constructing geometric models of the carotid bifurcation and computer simulation of endarterectomy surgery with the patches of various configurations. The purpose of this work is to identify the areas of the greatest risk of restenosis in the constructed models and to conduct a comparative analysis of risk factors when using the patches of different widths and shapes. Methods: The method is demonstrated on a reconstructed model of a healthy vessel. Its building is based on a preoperative computed tomography study of a particular patient's affected vessel. The flow in the vessel is simulated by computational fluid dynamics using data from the patient's ultrasound Doppler velocimetry. Risk factors are assessed through the hemodynamic indices on the vessel wall associated with Wall Shear Stress. Results: The distribution of risk zones in the healthy vessel, presumably leading to its observed lesion (plaque), is analyzed. Comparative evaluation of 10 various patches implantation results is carried out and the optimal variant is determined. The proposed method can be used to predict the hemodynamic results of surgery using patches of various sizes and shapes.
Elucidating Macular Structure-Function Correlations in Glaucoma
Authors: Giammaria Sara , Sharpe Glen , Oksana Dyachojk , Rafuse Paul , Lesya Shuba , Nicolela Marcelo , Vianna Jayme , Chauhan Balwantray
Published: January 2022

Correlation between structural data from optical coherence tomography (OCT) and functional data from the visual field (VF) may be suboptimal because of poor mapping of OCT measurement locations to VF test stimuli. We tested the hypothesis that stronger structure-function correlations in the macula can be achieved with fundus-tracking perimetery, by precisely mapping OCT measurements to VF sensitivity at the same location. The conventional 64 superpixel (3°x3°) OCT grid was mapped to VF sensitivities averaged in 40 corresponding VF units with standard automated perimetry (conventional mapped approach, CMA) in 38 glaucoma patients and 10 healthy subjects. Similarly, a 144 superpixel (2°x2°) OCT grid was mapped to each of the 68 VF locations with fundus-tracking perimetry (localized mapped approach, LMA). For each approach, the correlation between sensitivity at each VF unit and OCT superpixel was computed and the maximum value used to generate vector maps. CMA yielded significantly higher structure-function correlations compared to LMA. Only 20% of the vectors with CMA and <5% with LMA were within corresponding mapped OCT superpixels, while most were directed towards loci with structural damage. Measurement variability and patterns of glaucomatous damage are more likely to affect the correlations rather than precise mapping of VF stimuli.
Superior immunity that allows neutralization of all SARS-CoV-2 variants of concern develops in COVID-19 convalescents and naïve individuals after three vaccinations
Authors: Protzer Ulrike , Wratil Paul , Stern Marcel , Priller Alina , Willmann Annika , Almanzar Giovanni , Vogel Emanuel , Feuerherd Martin , Cheng Cho-Chin , Yazici Sarah , Christa Catharina , Jeske Samuel , Lupoli Gaia , Albanese Manuel , Mejías-Pérez Ernesto , Bauernfeind Stefan , Graf Natalia , Mijocevic Hrvoje , Vu Martin , Tinnefeld Kathrin , Wettengel Jochen , Hoffmann Dieter , Muenchhoff Maximilian , Dächert Christopher , Mairhofer Helga , Krebs Stefan , Steininger Philipp , Blum Helmut , Hornung Veit , Liebl Bernhard , Überla Klaus , Prelog Martina , Knolle Percy , Keppler Oliver , Fingerle Volker , Graf Alexander
Published: January 2022

Infection-neutralizing antibody responses after SARS-CoV-2 infection or COVID-19 vaccination are an essential part of antiviral immunity. This immune protection is challenged by the occurrence of SARS-CoV-2 variants of concern (VoCs) with immune escape properties, such as omicron (B.1.1.529) that is rapidly spreading worldwide. Here, we report neutralizing antibody dynamics in a longitudinal cohort of COVID-19 convalescent and naïve individuals vaccinated with mRNA BNT162b2 by quantifying anti-SARS-CoV-2-spike antibodies and determining their avidity and neutralization capacity. A superior infection-neutralizing capacity against all VoCs, including omicron, developed by either two vaccinations of convalescents, or a third vaccination or breakthrough infection of twice-vaccinated naïve individuals. These three consecutive spike antigen exposures resulted in an increasing neutralization capacity per anti-spike antibody unit and were paralleled by stepwise increases in antibody avidity. In conclusion, an infection/vaccination-induced hybrid immunity or a triple immunization induces high-quality antibodies resulting in superior neutralization capacity against VoCs, including omicron.
Policy Insight from Renewable Energy, Foreign Direct Investment (FDI) and Urbanization towards Climate Goal: Insight from Indonesia
Authors: Udemba Edmund Ntom , Philip Lucy Davou
Published: January 2022

This is an expository study towards ascertaining the ability of Indonesia in mitigating carbon emission. Indonesia is positioned as among the best performing economies in Southeast Asia because of its vigorous fiscal management and sustained economic growth over the years. The country’s foreign investment inflow increased to 14% in 2019, largely in gas, electricity, water, and transportation because of the viability of its macroeconomic reforms. To test the environmental implication of this macroeconomic performance of Indonesia and to see its ability to achieve carbon neutrality, we adopt Indonesian quarterly data of 1990Q1- 2018Q4 for empirical analysis. Relevance Instruments in the economic performance of Indonesia such as urbanization, foreign direct investment (FDI) and renewable energy source are all adopted for accurate estimations and analysis of this topic. Different approaches such as structural break test, autoregressive distributed lag (ARDL)-bounds testing and granger causality are all adopted in this study. Our analysis and policy recommendations are based on short run and long run ARDL dynamics and granger causality. Findings from ARDL confirmed, negative relationship between carbon emission and renewable energy source, FDI and urbanization. Also, a U-shape instead of inverted U-shape EKC is found confirming the impeding implication of Indonesian economic growth to its environmental performance if not checkmate. From granger causality analysis, all the variables are seen transmitting to urbanization in a one-way causal relationship. Also, FDI and renewable energy prove to be essential determinants of the country’s environment development, hence, FDI is seen transmitting to both energy source (fossil fuels and renewables) in a one- way causal relationship. Renewable energy is as well seen having two ways causal relationship with both carbon emission and fossil fuels. This result has equally exposed the significant position of the three instruments (urbanization, FDI and renewable energy source) in Indonesia environment development.
Novel AI to avert the mental health crisis in COVID-19: Novel application of GPT2 in Cognitive Behaviour Therapy
Authors: A Rajagopal
Published: January 2022

The effect of the COVID-19 pandemic on mental health is substantial. The World Health Organization has called for action to avert an impending mental health crisis. To respond to this call, this paper contributes a novel application of Deep Learning in Natural Language Generation (NLG) to seed healthy thoughts for mental health therapy. For the 1st time in literature, a transfer learning capable large neural network with more than 100 million parameters for a NLG based mental health therapy application is proposed & demonstrated. This AI is designed to address scalable impact for millions of families with a timely health intervention in a privacy-safe approach. To the best of our knowledge, this is the first research paper to apply GPT2 (Generative Pretrained Transformer) for Cognitive Behavior therapy (CBT). Further, the paper demonstrates the proposed neural network architecture with a lab prototype implementation with reproducible results. This paper demonstrates this AI’s ability to generate conditional synthetic human-like text intended to seed a healthy mental outlook. This is accomplished by fine tuning a pre-trained GPT2 language model. The source code and video demonstration is contributed at https://sites.google.com/view/ai-in-mental-health.Also, for the 1st time in literature, a novel idea of NLU (Natural Language Understanding) activated NLG therapy is demonstrated with reproducible results using a BERT based classifier to activate the GPT2 based therapy. Performance of GPT2 models of three different sizes (124, 355, 774 million parameters) was the same for a very small dataset, thus a small GPT2 model is suggested for on-device AI inference. This AI is a step forward in responding to WHO’s call for action to avert the crisis. Towards addressing all the three dimensions of the monumental challenge, the paper designed a novel AI architecture by taking advantage of both BERT & GPT2. It also demonstrated the feasibility of Transformers-based AI for developing a mental health therapy solution. Further, this paper contributed an open-source AI prototype to support research communities to transform global mental wellness.
Identification of Multi-omics Biomarkers and Construction of the Novel Prognostic Model for Hepatocellular Carcinoma
Authors: Yan Xiaokai , Xiao Chiying , Yue Kunyan , Chen Min , Zhou Hang , Liu Xiao
Published: January 2022

Genome changes play a crucial role in carcinogenesis, and many biomarkers can be used as effective prognostic indicators in various tumours. Although previous studies have constructed many predictive models for hepatocellular carcinoma (HCC) based on molecular signatures, the performance is unsatisfactory. To fill this shortcoming, we hope to build a more accurate predictive model to guide prognostic assessments of HCC. We use the TCGA to identify crucial biomarkers and construct single-omic prognostic models through difference analysis, univariate Cox, and LASSO/stepwise Cox analysis. The performances of single-omic models were evaluated and validated through survival analysis, Harrell’s concordance index (C-index), and receiver operating characteristic (ROC) curve. A multi-omics model was built and evaluated by decision curve analysis (DCA), C-index, and ROC analysis. Multiple mRNAs, lncRNAs, miRNAs, CNV genes, and SNPs were significantly associated with the prognosis of HCC. Five single-omic models were constructed, and the mRNA and lncRNA models showed good performance with c-indexes over 0.70. The multi-omics model presented a quite predictive solid ability with a c-index over 0.80. In this study, we identified many biomarkers that may help study underlying carcinogenesis mechanisms in HCC. In addition, we constructed multiple single-omic models and an integrated multi-omics model that may provide practical and reliable guides for prognosis assessment and treatment decision-making.
RESEARCH PROTOCOL: Cervical Arthroplasty Cost Effectiveness Study (CACES) Economic Evaluation of Anterior Cervical Discectomy With Arthroplasty Versus Anterior Cervical Discectomy With Fusion in the Surgical Treatment of Cervical Degenerative Disc Disease, a Randomized Controlled Trial.
Authors: Schuermans Valérie N.E. , Smeets Anouk Y.J.M. , Boselie Toon F.M. , Candel Math M.J.J. , Curfs Inez , Evers Silvia M.A.A. , Santbrink Henk Van
Published: January 2022

IntroductionTo date, there is no consensus on which anterior surgical technique is more cost-effective in treating cervical degenerative disc disease (CDDD). The most commonly used surgical treatment for patients with single- or multi-level symptomatic CDDD is anterior cervical discectomy with fusion (ACDF). However, new complaints of radiculopathy and/or myelopathy commonly develop at adjacent levels, also known as clinical adjacent segment pathology (CASP). The extent to which kinematics, surgery-induced fusion, natural history and progression of disease play a role in the development of CASP remain unclear. Anterior cervical discectomy with arthroplasty (ACDA) is another treatment option that is thought to reduce the incidence of CASP by preserving motion in the operated segment. While ACDA is often discouraged, as the implant costs are higher while the clinical outcomes are similar to ACDF, preventing CASP might be a reason for ACDA to be a more cost-effective technique in the long-term.Methods and analysisIn this randomized controlled trial, patients will be randomized to receive ACDF or ACDA in a 1:1 ratio. Adult patients with single- or multi-level CDDD and symptoms of radiculopathy and/or myelopathy will be included. The primary outcome is cost-effectiveness and cost-utility of both techniques from a healthcare and societal perspective. Secondary objectives are the differences in clinical and radiological outcomes between the two techniques, as well as the qualitative process surrounding anterior decompression surgery. All outcomes will be measured at baseline, and every six months until four years post-surgery.DiscussionHigh-quality evidence regarding the cost-effectiveness of both ACDA and ACDF is lacking; to date, there are no prospective trials from a societal perspective. Considering the ageing of the population and the rising healthcare costs, there is an urgent need for a solid clinical cost-effectiveness trial addressing this question.
Pria sebagai Privileged Allies dalam Gerakan Feminis HeForShe untuk Memperjuangkan Hak Pekerja Wanita di Indonesia
Authors: Ramadhaniati Shintya Giri , Pattipeilhy Shary Charlotte Henriette , Utama Tri Cahya
Published: January 2022

Abstract: Gender inequality is a problem faced throughout the world, including in Indonesia, where the patriarchal system causes women to often get injustice from various sectors, especially the work sector. In 2014, UN Women initiated the formation of HeForShe by making men as agents of change so that women can live equally without discrimination. This research then aims to see why the HeForShe organization involves men in efforts to address gender inequality in Indonesia. This research also uses qualitative methods with various data sources from the HeForShe organization, the Government of Indonesia and the Ministry of PPPA. The theory used is Liberal Feminists with the concept of men as privileged allies. The results of this study indicate that men as privileged allies in the struggle for the rights of women workers in Indonesia. The support provided by Indonesian men currently varies from learning about gender equality to building movements to support the elimination of violence against women. It is through this contribution that women's voices will be heard and gender equality actions will be better realized.

Keywords: Indonesia, Gender Inequality, HeForShe, Privileged Allies, Equality, Rights of Women Workers

 

Abstrak: Ketidaksetaraan gender merupakan permasalahan yang dihadapi di seluruh dunia termasuk di Indonesia dimana sistem patriarki menyebabkan wanita seringkali mendapatkan ketidakadilan dari berbagai sektor terutama sektor pekerjaan. Pada tahun 2014, UN Women menginisiasikan terbentuknya HeForShe dengan menjadikan pria sebagai agen perubahan agar wanita bisa hidup setara tanpa diskriminasi. Penelitian ini kemudian bertujuan untuk melihat mengapa organisasi HeForShe melibatkan pria dalam upaya penanganan ketidaksetaraan gender di Indonesia. Penelitian ini juga menggunakan metode kualitatif dengan berbagai sumber data dari organisasi HeForShe, Pemerintah Indonesia serta KemenPPPA. Teori yang digunakan adalah Feminis Liberal dengan konsep pria sebagai privileged allies. Hasil dari penelitian ini menunjukkan bahwa pria berperan sebagai privileged allies dalam perjuangan hak pekerja wanita di Indonesia. Dukungan yang diberikan pria Indonesia saat ini sangat beragam mulai dari mempelajari mengenai kesetaraan gender sampai membangun gerakan untuk mendukung penghapusan kekerasan terhadap wanita. Melalui kontribusi inilah suara wanita akan lebih didengar dan kesetaraan gender akan terwujud dengan lebih baik.

Kata Kunci: Indonesia, Ketidaksetaraan Gender, HeForShe, Privileged Allies, Kesetaraan, Hak Pekerja Wanita.
Correlations and commuting transfer matrices in integrable unitary circuits
Authors: Claeys Pieter W. , Herzog-Arbeitman Jonah , Lamacraft Austen
Published: January 2022

We consider a unitary circuit where the underlying gates are chosen
to be \check{R}Ř-matrices
satisfying the Yang-Baxter equation and correlation functions can be
expressed through a transfer matrix formalism. These transfer matrices
are no longer Hermitian and differ from the ones guaranteeing local
conservation laws, but remain mutually commuting at different values of
the spectral parameter defining the circuit. Exact eigenstates can still
be constructed as a Bethe ansatz, but while these transfer matrices are
diagonalizable in the inhomogeneous case, the homogeneous limit
corresponds to an exceptional point where multiple eigenstates coalesce
and Jordan blocks appear. Remarkably, the complete set of (generalized)
eigenstates is only obtained when taking into account a combinatorial
number of nontrivial vacuum states. In all cases, the Bethe equations
reduce to those of the integrable spin-1
chain and exhibit a global SU(2)
symmetry, significantly reducing the total number of eigenstates
required in the calculation of correlation functions. A similar
construction is shown to hold for the calculation of out-of-time-order
correlations.
Tecnologías disruptivas: Contexto Político-Jurídico, Desafíos y Oportunidades en Latinoamérica
Authors: Stella Rodríguez Gladys
Published: January 2022

En el presente trabajo se contextualizan las denominadas tecnologías disruptivas, explicando su naturaleza y principales características que son parte al ecosistema digital; se describen y ejemplifican de acuerdo a los siguientes autores: Vidal, Gavilondo, Rodríguez y Cuellar (2015); Boude y Andrea (2017); Rodríguez, Vidal y Martínez (2018); Mena, (2018); Vidal, Lio y Santiago (2018) y Naranjo (2018). De igual forma, se exponen de manera general, las principales estrategias en materia de políticas y leyes digitales y de conectividad en Latinoamérica. Se detallan tres casos de estudio, a fin de exponer el marco político y jurídico que describen las acciones y objetivos que estos tres Estados del Cono Sur han establecido para el abordaje de estas tecnologías de cuarta revolución industrial. Finalmente, se exponen los desafíos y oportunidades que se desprenden del análisis. Para ello, la metodología de investigación que se siguió es no experimental de carácter teórica sobre la base de fuentes bibliográficas actuales; planes de políticas de Colombia, Argentina y Uruguay en los temas de digitalización y, los principales informes de organismos internacionales. Concluyéndose que la tecnología ha permeado la existencia humana y, resulta de alto cuidado en materia de tecnologías disruptivas, no establecer límites en su uso, reconociendo que hay desafíos aun por superar y oportunidades que aprovechar a fin de garantizar el bienestar de la colectividad y, la asignación de responsabilidad frente a los abusos en el uso de estas tecnologías disruptivas.
Towards sustainable development in a transition economy: The case of eco-industrial parks in Ukraine
Authors: Petrushenko Mykola , Burkynskyi Borys , Shevchenko Hanna , Baranchenko Yevhen
Published: January 2022

Sustainable development for transition economies is an opportunity to accelerate and complete socio-economic transformations and at the same time an additional responsibility in situations of instability and uncertainty. The chances for strengthening sustainability are growing within the organized innovation space, which makes it possible to model scenarios of ecologically oriented development and, with the help of state and international support, to start their implementation. The paper aims to analyze the possibilities and directions of creating eco-industrial parks in a transition economy. It uses an innovative helix model in its triple, quadruple and quintuple variations for functioning and sustainable development of industrial parks in Ukraine.The study adopts a descriptive comparative analysis of data on the planning and implementation of economic, primarily environmentally relevant, activities. Based on the analysis and description of exogenous factors, in particular within GEIPP, a SWOT table on the potential of eco-industrial parks was formed. The directions of development of industrial, technological, and scientific parks in Ukraine are determined using the quintuple helix model on the plane of “knowledge-innovation”, in particular on quadruple helix transition to sustainability through the simultaneous development of socially oriented and environmental activities. Within the legislation, it is proposed to approve a sustainable form of artificially separated innovation parks, namely the “eco-industrial park”. One of the conditions for advanced sustainable development in Ukraine is the creation of a national program to support the transformation of innovation parks into their environmental versions 2.0 and 3.0, as well as investing in greenfield eco-industrial parks.
Empreendedorismo e prática:
Authors: Leal Alves Ferreira Felipe , Antonio Prado Gimenez Fernando , Otavio Mussi Augusto Paulo , Leal Valente Daniel
Published: January 2022

Nesta pesquisa buscou-se verificar quais ações são tomadas pelos empreendedores quando estão abrindo um negócio próprio, por meio das categorias práxis, práticas e praticantes do campo da estratégia como prática. Para isso, foram realizadas entrevistas guiadas com quatro empreendedores de Curitiba, Paraná. A análise das respostas foi realizada pela técnica de análise da narrativa e os resultados apontaram, em geral, que o empreender começa na intenção e movimento em ser dono/dona do próprio negócio, numa área com a qual tenha certa afinidade, com a elaboração do plano de negócio, declaração de missão, procura por parcerias, bem como no desenvolvimento de ações básicas das áreas clássicas da Administração - Finanças, Marketing, Produção e Gestão de Pessoas. Nisso, os papéis de empreendedor e gestor se misturam e confundem. Sugere-se que, em pesquisas futuras, outros processos de criação de novas organizações sejam acompanhados, de diferentes regiões, setores e idades de empreendimentos.
The mediating effect of emotion regulation on the mindfulness and impulsivity of high school students
Authors: Lokita Karisa Elisabeth , Siahaan Frieda Maryam Mangunsong , Widyasari Pratiwi
Published: January 2022

During adolescence, impulsivity usually escalates, increasing the risk of addiction and affecting academic achievement negatively. Mindfulness has been found to be one of the ways to regulate impulsivity, and emotion regulation can mediate the relationship between mindfulness and impulsivity. This research therefore aims to establish whether emotion regulation mediates the relationship between mindfulness and impulsivity amongst high school students. Quantitative research employing Hayes’ PROCESS mediation analysis was conducted. The participants, 390 Indonesian high school students aged 15-18, were collected using online questionnaires measuring mindfulness, impulsivity, and emotion dysregulation. The results show that emotion regulation partially mediated the relationship between mindfulness and impulsivity (ab = -.11, BootSE = 0.02, BootCI 95% [-0.16, -0.07]). Mindfulness increased emotion regulation skills, which in turn reduced impulsivity in high school students. The implications of the study are important in helping adolescents manage impulsiveness during the period of vulnerability to risk-taking. The use of mindfulness in schools could help manage the emotional and behavioral problems of high school adolescents.
Changing maladaptive beliefs among individuals with coronary heart disease using video information
Authors: Ginting Henndy , Näring Gérard W. B. , Becker Eni Sabrine , Tedjokusumo Pintoko
Published: January 2022

Many individuals with coronary heart disease (CHD) have maladaptive beliefs which might increase anxiety and depression. This study investigates the impact of using video information to convey facts and correct misconceptions about CHD in individuals. 150 individuals with CHD were assigned to either the control group or one of two experimental groups. The participants completed the York Cardiac Beliefs Questionnaire in the baseline measure immediately after first viewing the video (time 1), and after viewing the video for six times within two weeks (time 2). The Beck Anxiety Inventory and Beck Depression Inventory II were completed in the baseline and at time 2. Multiple repeated measures anova shows that after the intervention, participants’ maladaptive beliefs, anxiety and depression were reduced in both experimental groups. Yet, it did not happen in the control group. It indicates that the video information corrects maladaptive beliefs, and reduces anxiety and depression levels in individuals with CHD.
Propagación mediante semilla botánica de Parastrephia quadrangularis y Baccharis tricuneata en San José de Aymará – Huancavelica, Perú
Authors: Montero Terry Solange
Published: January 2022

En este estudio se presentan los resultados sobre la propagación por semillas en el vivero de la comunidad San José de Aymará durante el 2005. Se desea contribuir a mejorar la metodología de propagación de Parastrephia quadrangularis (Meyen) Cabrera y Baccharis tricuneata (Lam) Pers., ya que no hay mayores antecedentes para su manejo en el vivero. Se probaron tres tratamientos o técnica de propagación (bolsas de 10 × 18 cm, bolsas de 13 × 18 cm y platabanda) y tres sustratos: 1) turba: materia orgánica: tierra agrícola, 2) arena: materia orgánica: tierra agrícola, y 3) materia orgánica: tierra agrícola, obteniendo un total de 9 combinaciones. Considerándose en cada combinación los siguientes parámetros: supervivencia en el vivero, altura (cm) y perímetro al cuello de raíz (cm). Se obtuvo que ambas especies responden favorablemente a la propagación utilizando semillas. Resultando para P. quadrangularis la mejor combinación bolsas de 13 × 18 cm y sustra[1]to (materia orgánica: tierra agrícola), obteniendo un incremento promedio en altura entre 0.71 – 0.91 cm/mes; esta especie llega a desarrollarse en todos los sustratos empleados en el vivero. Por otro lado, B. tricuneata obtuvo mejores resultados utilizando bolsas 13 × 18 cm y sustrato (materia orgánica: tierra agrícola: turba), obteniendo un incremento promedio en altura entre 1.04 – 1.09 cm/mes. Sin embargo, resultó nulo el uso del sustrato (materia orgánica: tierra agrícola: arena). La alta mortalidad inicial en la plantación indica que todas las plantas desarrolladas en platabandas (a raíz desnuda), para ambas especies, requieren de más tiempo en el vivero e investigación.
Oferta de leña de los bosques nativos comunales en la cordillera del Vilcanota, Cusco, Perú
Authors: Gil-Mora Juan Eduardo , Álvarez-Moscoso Modesta Esther , Sánchez-Valenzuela Graciela , Baca-Flores Jesús Ángel
Published: January 2022

Diversos factores han contribuido a la pérdida y degradación de los bosques andinos, especial[1]mente de los altos Andes por encima de los 3 200 m de altitud, donde se desarrolló el presente trabajo; el ámbito de estudio se halla en la cordillera del Vilcanota que es uno de los ramales meri[1]dionales de la cordillera oriental de los Andes; la importancia de los ecosistemas forestales andinos radica primordialmente en la relación del bosque como medio natural (importancia ecológica) y también en la relación del bosque como uso y aprovechamiento por las poblaciones (importancia económica). Los bosques en los altos Andes son residuales y se hallan sometidos a una extracción constante debido a que ofertan leña, madera y otros servicios ecosistémicos; por lo tanto, tienen importancia en la economía familiar de las comunidades campesinas altoandinas del Cusco y, des[1]de hace décadas se observa la creciente escasez de leña para uso doméstico. El objetivo del trabajo fue evaluar la oferta de leña que brindan los bosques nativos en los altos Andes; se evaluaron 18 bosques nativos comunales pertenecientes a 11 comunidades campesinas y a dos provincias (Calca  y Urubamba) cuya superficie total es 764 ha con una oferta total de leña equivalente a 169 699,71 t; la tipología de los bosques identificados pertenece a bosque mixto arbóreo, matorral espinoso y bosque de Polylepis. Para el análisis, la zona de estudio fue dividida en dos zonas y para la obtención de la información se utilizaron transectos lineales para el matorral espinoso y parcelas cuadradas para el bosque mixto y el de Polylepis; para la determinación del volumen de leña ofertada por los bosques en campo se midieron la circunferencia basal y distal y, la longitud del fuste, y se emplearon métodos experimentales de laboratorio.
Phytochemical Content and Potential Health Applications of Pecan [Carya
illinoinensis (Wangenh) K. Koch] Nutshell
Authors: del C. Reyes-Vázquez Nohemí , de la Rosa Laura A. , Morales-Landa Juan Luis , García-Fajardo Jorge Alberto , García-Cruz Miguel Ángel
Published: January 2022

Background:

The pecan nutshell contains phytochemicals with various biological activities
that are potentially useful in the prevention or treatment of diseases, such as cancer, diabetes,
and metabolic imbalances associated with heart diseases.

Objective:

The aim of this study is to update this topic by means of a literature review and include
those studies that contribute to the knowledge of the chemical composition and biological activities
of pecan nutshell, particularly those related to the therapeutic potential against some chronic degenerative
diseases associated with oxidative stress.

Method:

Exhaustive and detailed review of the existing literature was conducted using electronic
databases.

Conclusion:

The pecan nutshell is a promising natural product with pharmaceutical uses in various
diseases. However, additional research related to the assessment of efficient extraction methods
and characterization, particularly the evaluation of the mechanisms of action in new in vivo models,
is necessary to confirm these findings and development of new drugs with therapeutic use.
Mechanistic Study on Gold(I)-Catalyzed Unsaturated Spiroketalization
Reaction
Authors: Sharma Kamlesh
Published: January 2022

The mechanism of metal-catalyzed spiroketalization of propargyl acetonide is explored
by employing DFT with the B3LYP/6-31+G(d) method. Acetonide is used as a regioselective regulator
in the formation of monounsaturated spiroketal. The energies of transition states, intermediates,
reactants and products are calculated to provide new insight into the mechanism of the reaction.
The energetic features, validation of the observed trends in regioselectivity are conferred in
terms of electronic indices via FMO analysis. The presence of acetonide facilitates a stepwise spiroketalization
as it masks the competing nucleophile, and thus hydroxyl group present exclusively
acts as a nucleophile. The vinyl gold intermediate 3 is formed from 2 via activation barrier TS1.
This is the first ring formation, which is 6-exo-dig cyclization. The intermediate 3 is converted into
allenyl ether 4, which isomerizes to the intermediate oxocarbenium ion 5 via activation barrier TS2.
The intermediate 5 cyclizes to 6 via TS3. This is the second ring formation. The intermediate 6 on
protodeauration turns into 6,6-monounsaturated spiroketal 7. It is concluded that acetonide as a
protecting group serves the purpose, and thus a wide range of spiroketals can be prepared regioselectivity.
In silico ADME/Pharmacokinetic and Target Prediction Studies of
Ethambutol as Drug Molecule
Authors: Joshi Arnav Ajinkya , Khairnar Sakshi V. , Chaudhari Hemchandra K.
Published: January 2022

Background:

The conventional approach for the development of any pharmaceutically active
molecule is a time-consuming and costly process because the synthesis is followed by laboratory
tests which are then followed by long clinical trials. Hence, a faster approach is desired. This article
discusses Ethambutol, a frontline anti-tubercular drug that has its properties predicted by the SwissADME
tool and the results would be compared with the findings published in the literature.

Objective:

The main objective is to study the predicted and experimental ADME properties, compare
them and study the predicted targets and understand the use of SwissADME for designing other drug
molecules.

Method:

SwissADME, an online tool for ADME prediction, was used along with Swiss Target Prediction
to understand the targets of the drug. Further, experimental data was obtained from the available
scientific literature.

Results:

We found certain similarities between the predicted and experimental data. However, there
were some variations, depending on the testing conditions. The results are interpreted ahead in the
article.

Conclusion:

Ethambutol’s predicted ADME properties are discussed and as per findings from results,
it can be concluded that other drug molecules can be similarly predicted using these tools. Also, based
on predicted data, we can reformulate and prepare some different preparations of the drug.
Effect of Sodium Valproate Treatment on the Cardiac Index in New Cases with Status Epilepticus
Authors: Radgoudarzi Mohammad , Vafaee-Shahi Mohammad , Naderi Fatemeh
Published: January 2022

Background:

Sodium valproate is an antiepileptic drug primarily used to treat status epilepticus [SE]; however, its effect on cardiac function is unclear. This study aimed to examine the effect of 6 months of sodium valproate treatment on the cardiac index in new cases with status epilepticus.

Methods:

In this cross-sectional study, 30 cases with status epilepticus [18 boys and 12 girls] who were admitted to the Pediatric Intensive Care Unit of Hazrat-e Rasool Hospital were enrolled. Information on basic demographic and clinical data of all children, such as age, weight, gender, blood pressures, and underlying diseases, was recorded. Echocardiography and electrocardiogram [ECG] were performed for all cases before and after the treatment.

Results:

There were no abnormalities in ECG parameters [including PR, QRS, and QT intervals] after 6 months of treatment with sodium valproate. No significant differences were found in echocardiographic parameters, including blood pressure, pulmonary artery pressure [PAP], right ventricular [RV] size, diastolic dysfunction,], Tie index, end-diastolic volume [EDV], ejection fraction [EF], and TAPSE before and after study [p>0.05].

Conclusion:

Administration of sodium valproate over 6 months is not associated with a serious adverse effect on heart function in children with status epilepticus.