bluuebunny/crossref_metadata_2025 huggingface dataset:
Video Consultations in Primary Care Outside Office Hours (Preprint)
Authors: Nebsbjerg Mette Amalie , Bomholt Katrine Bjørnshave , Vetsergaard Claus Høstrup , Christensen Morten Bondo , Huibers Linda
Published: June 2023

BACKGROUND

Out-of-hours primary care (OOH-PC) is facing increasing demands and workload with many negative consequences, including longer waiting time and increased risk of treatment delay and safety incidents. During the COVID-19 pandemic, video consultation (VC) was introduced as an alternative to face-to-face contact. We hypothesize that VC contributes to sustainable OOH-PC by changing patient flows, decreasing workload, and reducing waiting time.

OBJECTIVE

This study aims to evaluate the use of video in telephone triage in OOH-PC by studying user rate, the effect on contact patterns, and patient characteristics related to receiving a VC.

METHODS

We conducted a register-based study of VC use in OOH-PC, including all Danish residents contacting OOH-PC in the regions of Central Denmark, Southern Denmark, Northern Denmark, and Zealand. The study population will be followed from birth, immigration, or March 1, 2020 (whichever came last), until death, emigration, or December 31, 2021 (whichever comes first). We will use national registers, linking data with the unique personal identification number. We plan to conduct descriptive analyses, calculating the proportion of VC of all teletriage consultations per month during the study period. We plan to use regression models to measure the association between VC and triage outcome and the association between VC and patient characteristics, calculating risk ratios and 95% CIs. Both crude and mutual adjusted risk ratios for patient characteristics will be presented.

RESULTS

Data analyses started in May 2022.

CONCLUSIONS

A preliminary conclusion will be presented at the conference.
A Survey of Internet Performance During COVID-19 (Preprint)
Authors: Dittmann Lars
Published: June 2023

BACKGROUND

Since the beginning of 2020, many societal systems have been used to extend the health care system, which were not planned for, and as such, there is concern for its collapse. Clearly, the collapse of the health care system, primarily hospitals, has been a key concern, and many initiatives, including lockdown and curfew, were taken to avoid such a collapse. The internet was the key platform used to enable people to work from home, provide remote teaching, conduct meetings on the web, etc. However, when it comes to data communication and processing, the risk of collapse is not the only risk, and maybe not even the biggest one. Many systems were not properly adapted for used in such a hurry, which did not allow time (and concern) for a proper risk and privacy assessment.

OBJECTIVE

This paper presents internet performance statistics and analyzes how this knowledge can be used in future designs of internet-based telemedical solutions.

METHODS

Statistics regarding traffic increases and security attacks on the internet during 2020 and 2021 were analyzed.

RESULTS

The internet did not collapse during the COVID pandemic—as many people had predicted. However, the massive use of the internet, in new innovative ways, created a number of new opportunities for cybersecurity breach. Especially, the use videoconferences enabled made-in-middle attacks, phishing, and other classical breaches in new ways due to insufficient authentication and content encryption.

CONCLUSIONS

Even though a large amount of experience has been gathered with respect to scaling eHealth systems, a minimum amount of improvement with respect to privacy and security has been identified.
Development of a Pilot Introductory Advanced Cardiovascular Resuscitation Course for Senior Medical Students in Switzerland: Student-Driven Implementation Study (Preprint)
Authors: Herren Tara , Fivaz Loris , Dufeil Eva , Golay Eric , Braun Ely , Straub Emilie , Nidegger Philippe , Grosgurin Olivier , Gartner Birgit Andrea , Suppan Mélanie , Suppan Laurent
Published: June 2023

BACKGROUND

Cardiac arrest is the most time-critical emergency medical students and junior physicians may face in their personal or professional life. However, many studies have shown that most of them lack the necessary knowledge and skills to efficiently perform resuscitation. This could be related to the fact that advanced cardiovascular resuscitation courses are not always part of the undergraduate medical curriculum.

OBJECTIVE

The aim of this study was to describe the development, pilot implementation, and assessment of an advanced cardiovascular resuscitation course designed to enable senior medical students to manage the initial resuscitation phase in case of cardiac arrest.

METHODS

An introductory advanced cardiovascular resuscitation course was developed on the initiative of fifth-year medical students, in collaboration with the prehospital emergency medical service team of the Geneva University Hospitals. The 60 slots available to the 157 members of the fifth-year promotion of the University of Geneva Faculty of Medicine were filled in less than 8 hours. This unexpected success prompted the creation of a first questionnaire, which was sent to all fifth-year students to determine the overall proportion of students interested in attending an advanced cardiovascular resuscitation course. This questionnaire was also used to assess basic life support education and experience among course participants. A postcourse questionnaire was used to gather feedback regarding the course and to assess student confidence regarding the resuscitation skills they had been taught.

RESULTS

Out of 157 fifth-year medical students, 73 (46%) completed the first questionnaire. Most thought that the current curriculum did not provide them with enough knowledge and skills regarding resuscitation and 85% (62/73) wished to attend an introductory advanced cardiovascular resuscitation course. All the participants who would have wanted to follow the full Advanced Cardiovascular Life Support course before graduating were set back by its cost (10/10, 100%). Of the 60 students who had registered for the training sessions, 56 (93%) actually attended. The postcourse questionnaire was completed by 42 (87%) students (out of 48 who had registered on the platform). They unanimously answered that an advanced cardiovascular resuscitation course should be part of the standard curriculum.

CONCLUSIONS

This study demonstrates the interest of senior medical students in an advanced cardiovascular resuscitation course and their willingness to see such a course integrated as a part of their regular curriculum.
Spectroscopic analysis of plant trace element incorporated silver nanoparticles synthesis from Datura metel l.
Authors: Krishnamoorthy Gurushankar , Chinnaiah K , Kannan Karthik , Maik Vivek , Potemkin V , Grishina M , Christopher Jeyaseelan S , Muthuvel A , Gnanasangeetha D
Published: June 2023

Here in we report, silver nanoparticles (Ag NPs) prepared from leaf extract of Datura metel L. via green synthesis method. Datura metel L. is an herbal medicinal plant of solanaceae family. The as - prepared Ag NPs characterized employing UV-Vis spectrometer, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDAX) techniques. The appearance of Surface Plasmon Resonance (SPR) peak at 415 nm suggested that creation of Ag NPs in UV-Vis spectrum. XRD pattern showed face centered cubic crystal structure of Ag NPs with organometallic complex phase. Peaks in FTIR spectrum reveal the existence of biomolecules. SEM image illustrate their clastic rock morphology and EDAX profile authenticate the company of Ag and plant trace element. The Cyclic voltammetry (CV), Choronopotentiometry, and Electrochemical impedance spectroscopy (EIS) analysis were performed as prepared Ag electrode. The specific capacitance of 267.59 F/g at 0.5 A/g and cyclic retention of 83.7% after charge-discharge 5000 cycles are obtained. Hence this material could be utilized as Supercapacitor energy storage devices.
Novel pilot bioreactor for scale up Gynura procumbens adventitious root culture
Authors: Manuhara Yosephine Sri Wulan , Kusuma Dannis Yuda , Kristanti Alfinda Novi
Published: June 2023

Adventitious root culture and the development of a bioreactor are methods to obtain biomass and plant bioactive compounds in large quantities faster than conventional plant cultivation. These technologies provide an excellent opportunity to produce biomass and bioactive compounds from plants, especially Gynura procumbens. Previous reports mentioned a small-scale bioreactor could increase biomass and bioactive compounds of G. procumbens adventitious roots. Therefore, a larger bioreactor for adventitious root culture is necessary to develop. In this study, the development of the 19 L pilot bioreactor was successful. The optimal condition for bioreactor sterilization is 1.8 bar for 60 min using an autoclave. We found that G. procumbens adventitious roots culture in pilot bioreactors has resulted in optimal biomass using MS-Tek media (technical grade) compared to MS-PA (pro analyze) media after 35 d of the culture period. Although, higher productivity of total phenolics and total flavonoids in G. procumbens roots has been achieved from MS-PA media rather than MS-Tek media. In further study, it is necessary to evaluate the effect of technical-grade chemicals on kinetics root growth and chemical uptake. The hope is to obtain a suitable media formulation with affordable cost for adventitious root culture production.
Nephroprotective Effects of Cardamom Essential Oil (Amomum compactum Soland. Ex Maton) in Kidney Cells
Authors: Hasanah Nisa Ul , Tafrihani Ahmad Syauqy , Zulfin Ummi Maryam , Salsabila Dhiya Ulhaq , Wardani Ratih Kurnia , Ikawati Muthi' , Meiyanto Edy , Jenie Riris Istighfari
Published: June 2023

Many chemotherapeutic agents cause various side effects, including nephrotoxicity. Doxorubicin, for example, increases the level of reactive oxygen species (ROS), leading to cell senescence in the kidneys. Cardamom essential oil (Amomum compactum Soland. ex Maton) contains compounds that exhibit antioxidant activity, such as 1.8-cineole, α-pinene, α-terpineol, and linalool. This study focused on exploring the potency of cardamom essential oil (CEO) as an anti-senescence induced by doxorubicin using Vero cells. CEO was obtained by steam distillation. The cytotoxic assay was carried out using trypan blue exclusion assay. We performed the 2',7'-dichlorodihydrofluorescein diacetate (DCFDA) staining and the senescence-associated beta-galactosidase (SA-β-gal) staining to measure the effect of CEO on intracellular ROS level and cell senescence, respectively. Analysis of the compounds with gas chromatography-mass spectrophotometry (GC-MS), revealed seven compounds with significant abundance, namely 1.8-cineole (50.82%), ß-pinene (12.43%), α-terpineol (8.50%), fenchone (4.10%), α-pinene (4.00%), sabinene (3.00%), and linalool (1.98%). The cytotoxicity assay of CEO on Vero cells showed an IC50 value of 178 μg/mL. Thus, the CEO is considered to be not cytotoxic and safe for normal kidney cells. Concentrations of 50 and 100 μg/mL reduced the senescence induced by doxorubicin. Therefore, the CEO has the potency as a nephroprotective agent in doxorubicin-induced senescence.
EVALUASI KINERJA KALSIUM BORAT SEBAGAI PENGGANTI PROPPANT PADA ABRASIVE PERFORATION MENGGUNAKAN COIL TUBING UNIT
Authors: Hafidz Abdurrahman , Yerizam Muhammad , Purnamasari Indah
Published: June 2023

Metode perforasi konvensional yang melibatkan bahan peledak memiliki banyak kekurangan terutama pada sisi transportasi dan penanganan, pengoperasian yang sulit serta kondisi berbahaya lain yang menyebabkan bahan peledak terjatuh kedalam sumur. Oleh karena itu, metode perforasi abrasif menjadi pilihan yang tepat untuk masa yang akan dating. Penggunaan proppant sebagai media abrasif yang umumnya digunakan, menimbulkan permasalahan pada pembersihan endapan di lubang sumur. Sehingga, penggunaan kalsium borat yang memiliki sifat abrasif dan dapat larut didalam HCl diharapkan dapat mengatasi permasalahan yang ada pada proppant agar tidak memerlukan tindakan pembersihan dan dapat mengehemat waktu operasi, biaya dan meningkatkan keamanan pada sisi operasional secara sekaligus. Pada studi kasus ini bertujuan untuk menganalisis efektifitas dari penggunaan kalsium borat pada perforasi abrasif. Data-data yang dijadikan sumber yaitu data primer yang didapat melalui pengamatan langsung pada saat eksekusi dan Data sekunder yang diperoleh dari sumber kedua dengan mengambil parameter-parameter yang dibutuhkan untuk hal analisis dan pembahasan ataupun melalui kajian pustaka yang mendukung studi kasus. Hasil analisis kedua data tersebut di bagi kedalam dua tahapan, pada tahapan eksekusi diperoleh bahwa durasi rata-rata dari 37 stages perforasi yang telah dilakukan sebesar 13,7 menit melebihi durasi yang dibutuhkan secara analisis yaitu 12,9 menit. Hal ini menunjukkan bahwa semua stage perforasi berhasil terlubangi. Sedangkan pada tahapan pasca perforasi abrasif, dilakukan pengamatan parameter produksi sumur selama 7 hari berupa laju alir produksi, kadar air, tekanan alir dan dan ukuran choke. Dari parameter tersebut dilakukan analisis sehingga diperoleh angka persentase yang menunjukkan efektivitas perforasi pada perforasi abrasif menggunakan kalsium borate berada diangka 84% atau 93 lubang yang efektif memproduksi dari total 111 lubang yang diperforasi. Dimana sangat memenuhi ekspektasi dari perusahaan berdasarkan Saudi Aramco Workover Manual.
Simulasi Proses Metanasi pada Power to Gas (PtG) dengan Model TREMP
Authors: Bisowarno Budi H. , Budyanto Samuel Billy
Published: June 2023

Peningkatan emisi gas rumah kaca telah menyebabkan pemanasan global dengan laju yang semakin cepat setiap tahunnya. Sementara itu, pemanfaatan pembangkit listrik terbarukan seperti dari tenaga angin dan tenaga surya mempunyai masalah akibat fluktuasi energi yang dihasilkan dan penyimpanan energi yang terbatas. Proses power to gas (PtG) dapat menjadi solusi alternatif untuk menyimpan energi listrik melalui proses elektrolisis air yang menghasilkan gas hidrogen dan mereaksikannya dengan emisi gas rumah kaca, yaitu gas karbon dioksida untuk menghasilkan gas metana. Gas metana selanjutnya dapat disimpan dalam infrastruktur gas alam. Fleksibilitas penerapan proses (PtG) ini memiliki tantangan tersendiri karena fluktuasi gas hidrogen hasil proses elektrolisis. Makalah ini mendiskusikan pengaruh variasi kondisi operasi dan modifikasi proses pada tahap metanasi proses PtG terhadap temperatur maksimum reaktor dan perolehan komposisi metana pada gas synthetic natural gas (SNG). Tahap metanasi dimodelkan dengan Topsoe’s Recycle Energy efficient Methanation Process (TREMP). Reaksi eksotermis dapat menyebabkan thermal runaway dengan peningkatan konsentrasi umpan akibat fluktuasi gas hidrogen. Berdasarkan simulasi menggunakan ASPEN Plus, umpan karbon dioksida berlebih dipilih karena rentang perubahan rasio umpan lebih lebar (0.25 – 0,5). Untuk meningkatkan fleksibilitas umpan, TREMP dengan karbon dioksida berlebih ini dapat menggunakan konfigurasi 3 (tiga) reaktor yang disusun secara seri. Kolom absorpsi dapa digunakan untuk pemisahan karbon dioksida berlebih dari aliran produknya dan menghasilkan gas SNG standar (94%).
STUDI AWAL KESTABILAN STRUKTUR KATALIS LOGAM TRANSISI PERIODE PERTAMA BERBASIS HZSM-5
Authors: Nugrahaningtyas Khoirina Dwi , Zalfa Syafira Nur , Rahmawati Fitria , Nurcahyo I.F. , Hidayat Yuniawan
Published: June 2023

Katalis logam transisi periode pertama (Fe, Co, Ni, Cu, atau Zn) berbasis Hydrogen Zeolite Socony Mobil – 5 (HZSM-5) merupakan katalis yang menjanjikan untuk berbagai macam reaksi. Pada penelitian ini akan dipelajari keperiodikan aktivitas dan kestabilan struktur katalis tersebut pada reaksi cracking anisol. Uji katalitik dilakukan dengan menggunakan reaktor semi alir. Produk dari hasil proses cracking anisol dianalisis menggunakan kromatografi gas-spektra massa (GC-MS), kemudian karakter katalis bekas seperti kristalinitas dan komposisi fasa dianalisis menggunakan X-ray diffraction (XRD), sedangkan luas permukaan dan porositas dianalisis menggunakan surface area analyzer (SAA). Hasil penelitian menunjukkan bahwa tidak nampak kaitan antara sifat periodik unsur dengan aktivitas katalitiknya.  Karakter setiap katalis yang telah digunakan mengalami sedikit perubahan pada komposisi fasanya, terutama katalis Fe/HZSM-5 dan Co/HZSM-5, sedangkan luas permukaan dan porositasnya mengalami penurunan.
Pengeringan Buah Tomat Menggunakan Tray Dryer dengan Bantuan Foaming Agent Tween 80
Authors: Sholeha Irdatus , Lestari Afrila Tutut Dwijati , Wibowo Jihan Nafila , Fadilah Siska Nuri , Arimbawa I Made , Muharja Maktum
Published: June 2023

Tomat merupakan buah yang mengandung kadar air cukup tinggi yang dapat menyebabkan proses pembusukan. Menjadikan tomat ke bentuk bubuk melalui proses pengeringan adalah salah satu cara untuk mengawetkan buah tomat. Penelitian ini bertujuan untuk mengetahui karakteristik serta pengaruh foaming agent tween 80 pada pengeringan buah tomat dengan variasi laju udara fan, waktu dan temperatur. Metode yang digunakan adalah metode pengeringan tray dryer. Penelitian ini menggunakan variabel laju udara fan 3, 4, 5, 6 m/detik, waktu 30, 40, 50, 60 menit serta suhu 40, 50, 60, 70°C. Hasil dari penelitian ini menunjukkan bahwa laju alir udara optimum untuk mengeringkan tomat yang sudah menjadi busa dengan ketebalan 3 mm yaitu 3 m/s. Waktu pengeringan optimum yaitu 50 menit, dimana pada waktu 50 menit tersebut telah tercapai laju pengeringan yang rendah. Suhu pengeringan optimum yaitu 70°C dengan kecepatan pengeringan 0,005 gram/detik dan moisture content basis kering sebesar 0,06. Dengan demikian, metode ini dapat menjadi solusi untuk mengoptimalkan proses pengeringan tomat secara efisien.
A Study on Brand Public Welfare Marketing Strategies in the Context of New Media: A Case Study of Pereira
Authors: Zhang Kaiyue
Published: June 2023

Public welfare marketing is an effective method for brands to improve their reputation and credibility. With the development of the Internet and social platforms, public welfare marketing needs new strategies to better play its role. This article summarizes the effective strategies for brand public welfare marketing in the context of new media by analyzing the public welfare marketing projects of the Perleya brand since 2021. Research has found that brand public welfare marketing needs to target the target audience, increase user engagement, and endow the brand with a certain image and spirit that meets consumer expectations through public welfare marketing. At the same time, public welfare marketing should strive to resonate emotionally with consumers, awaken the emotional factors of the audience, and also rely on the power of KOL and authoritative institutions to increase communication efforts and achieve the transfer of trust.
Artificial Intelligence in Sustainable Agriculture
Authors: Mathur Rashmi
Published: June 2023

Abstract: Humans have been inventing machines to accomplish arduous and time-consuming tasks. Technology has advanced to enable the development of machines that perceive and acquire data, understand language, retain it as knowledge, deduce information, reason, and solve problems. The widespread deployment of artificial intelligence is a milestone in the history of the transformative aspects of modern technology. Agriculture is a vital sector that supports economic growth and human subsistence and automation in this sector is a global concern. A vast majority of people in India's agrarian economy depend on agriculture for their livelihood, so it is crucial to promote sustainable agricultural practices. Due to population growth, conventional farming techniques can no longer keep up with food demand. Various novel automation technologies are being established to meet these needs and provide employability in this field. Ensuring food security despite climate change and population growth is a challenge for Artificial Intelligence. Recent environmental changes and climate catastrophes have affected agricultural production, and it is crucial to leverage technology to mitigate these impacts. Using technology tools like AI, Unmanned Aerial Vehicles (UAVs) or drones, and sensors is an important step towards sustainable agriculture. These biosensor tools can help farmers monitor soil moisture levels, soil alkalinity, pesticide and toxicity levels, and identify diseases and pests that affect crop health. Biosensors can also help detect disease-causing organisms, enabling farmers to take preventive measures to ensure increased crop productivity. The paper aims to review technological innovations and suggest steps to integrate technology for the benefit of society through sustainable agricultural practices.
Empty chair therapy untuk menurunkan gejala depresi pada remaja korban perundungan
Authors: Sekarini Anindyah , Dinni Siti Muthia
Published: June 2023

Depression is a disorder that leads to a more negative mood. The subject shows symptoms of depressive disorder in the form of depression affect, lost interest in doing activities or hobies and increased hypersomnia. Subject was an 15-year-old woman who had experienced as victims of bullying. The purpose of this case study is to reduce depressive symptoms through the empty chair. There are feelings of guilt and worthlessness, trouble concentrating to complete the school task, and looking future improperly. The assessment method were used interview, observation, psychological test, and BDI (Beck Depression Inventory). The intervention used in this case was Gestalt Therapy with Empty Chair Technique. Intervention target to decreased depression symptoms and helps subject to live well everyday. The results of the intervention showed that empty chair therapy effective in reducing depression symptoms in subject. There was decreased BDI score from 37 to 22. 
Depresi adalah gangguan yang mengarah ke suasana hati yang lebih negatif. Subyek menunjukkan gejala gangguan depresi berupa afek depresi, kehilangan minat dalam melakukan aktivitas atau hobi dan peningkatan hipersomnia. Subjek adalah seorang wanita berusia 15 tahun yang pernah mengalami sebagai korban bullying. Tujuan dari studi kasus ini adalah untuk mengurangi gejala depresi melalui kursi kosong. Ada perasaan bersalah dan tidak berharga, sulit berkonsentrasi untuk menyelesaikan tugas sekolah, dan memandang masa depan dengan tidak tepat. Metode penilaian yang digunakan adalah wawancara, observasi, tes psikologi, dan BDI (Beck Depression Inventory). Intervensi yang digunakan dalam kasus ini adalah Terapi Gestalt dengan Teknik Kursi Kosong. Target intervensi untuk mengurangi gejala depresi dan membantu subjek untuk hidup dengan baik setiap hari. Hasil intervensi menunjukkan bahwa terapi kursi kosong efektif dalam mengurangi gejala depresi pada subjek. Terjadi penurunan skor BDI dari 37 menjadi 22.
Anthropomorphism, Perceived Learning for Creation, and Growth Creative Mindset as Predictors of Acceptance Toward Artificial Intelligence Creativity
Authors: Jang YeiBeech
Published: June 2023

Despite the steady increase in art creations generated by artificial intelligence (AI), few empirical studies have examined public acceptance toward AI creativity and the factors influencing this acceptance. This study investigated the relationships among AI anthropomorphism, perceived
AI learning for creation, creative mindsets, and acceptance toward AI creativity. I conducted an online survey comprising 505 participants. The results showed that AI anthropomorphism, perceived AI learning for creation, and growth creative mindset were positive predictors of acceptance toward
AI creativity. Those with higher levels of AI anthropomorphism, perceived AI learning for creation, and a growth creative mindset were more likely to have stronger acceptance toward AI creativity. The findings of this study shed light on the mechanism of acceptance of AI creativity and provide
an opportunity to understand perceptions of human creativity.
Analysis of Protein Levels in Cow Bones from Kaledo Waste from Palu City Central Sulawesi
Authors: Anisa Cica , Hamzah Baharuddin
Published: June 2023

Kaledo (donggala ox leg) is one of the famous culinary in Central Sulawesi. The number of restaurants that provide kaledo menus causes problems, due to the lack of utilization of the bone waste, causing problems in the environment. People still don't know that beef bones still contain protein. Protein serves as a form of new tissue during the growth and development of the body. This study aims to determine the protein content of beef bones from kaleo waste from the city of Palu, Central Sulawesi, which was taken randomly from a kaledo restaurant. Determination of protein content in beef bones from kale waste using the Kjeldhal method. In the results of calculations that have been carried out with three repetitions, it was found that the protein content in Repetition1 was 3.85%, Repetition2 was 3.59% and Repetition3 was 4.2%. The average protein content of beef bones from kale waste is 3.88%. The results of this study are expected to be a source of information about the protein content contained in beef bones from kaleo waste and can be used further as a substance in the utilization of bone waste.
Impact of the Guru Penggerak Programme on Improving Leadership Competence in Numeracy Learning
Authors: Imron Imron , Mahmud Amir , Samsudin Achmad
Published: June 2023

Education of Guru Penggerak is the Government's innovation to prepare for future leadership transformation. Before becoming a leader, the teacher mobiliser is required to be the main actor in classroom learning and mobilise peers through a community of practice. Thus, they are expected to become leaders in school management and development. Candidate of Guru Penggerak, after undergoing Education and Training for 6 months covering 10 modules, will become student-centred learning leaders. The implementation of quality student-centred learning has not been optimal and equitable from one region to another. The low level of literacy and numeracy in the education report card has led the Government to launch the Merdeka Belajar Programme. The purpose of the research conducted on prospective Guru Penggerak is to determine the impact of Education of Guru Penggerak on improving learning through improving grades during education and increasing competence in self-development and learning leadership, knowing the motivation of prospective Guru Penggerak after completing education and whether literacy and numeracy materials are needed. The research method uses quantitative descriptive research using data collection techniques of interviews, documentation, questionnaires and observations, pre-test-post test scores and questionnaires on prospective Guru Penggerak. The results obtained from this study are an average increase from the pre-test score of 50.80 to the average post-test score of 64.58 or an increase of 13.77. From the questionnaire, the competence of self-development and others increased from 76.82% to 87.35%. For learning leadership competence there was an increase from 73.03% to 85.04%
COVID-19 outbreak and the global stock market liquidity
Authors: Phan Hong Mai , Dam Vu Duc Hieu
Published: June 2023

The purpose of this study is to examine how the COVID-19 outbreak affected the liquidity of stock markets across the world. By analyzing a sample including daily data from forty-seven stock markets, we found a positive relationship between monthly growth in the number of newly reported COVID-19 cases and monthly market trading volume growth during the period between December 2019 and January 2021. The research findings although contrary to the previous studies in the very early stages (McTier et al., 2013; Chaouachi & Chaouachi, 2020), are consistent with the actual developments up to the present. This implies that stock markets were relevant sources for investors to compensate for the foregone earnings caused by the interruption of economic activities. Therefore, appropriate measures, such as financial support for investors and listed companies as well as improvements in technological infrastructure and administrative procedures, should be implemented to maintain the activities of the stock market in each country. In addition, it is important for the regulators to closely monitor market trading activities and trends to issue early warnings to the market and take appropriate action in the event of a “bubble” in the market.
NARASI TOLERANSI BERAGAMA DI MEDIA SOSIAL
Authors: Al-Ayya Arina
Published: June 2023

Policies issued by the government and medical units to deal with the Covid-19 pandemic have somewhat affected people’s lives. One thing that is quite noticeable is the construction of communication on social media, which is increasingly being carried out by people globally. To build a ‘healthy climate’ on social media, the role of non-personal accounts in maintaining the integrity of religious tolerance is crucial. This article aimed to analyze the narrative of religious tolerance from the Twitter account of Komunitas Katolik Garis Lucu (@katolikG). Its existence as one of the accounts under the name of Garis Lucu (GL) indicates that they bring a spirit of peace in using social media. The current research described the existence of @katolikG’s account on social media and interpreted the messages concerning religious tolerance. The research used a qualitative approach with data collection based on a literature study. In presenting the data, the researcher utilized the descriptive-analytical method and employed the semiotic analysis of Roland Barthes to analyze the data. The results revealed that the Twitter account of @katolikG seeks to build religious tolerance on social media by creating messages within the scope of global multiculturalism. As its messages are wrapped in the form of jokes, memes, and satire, @katolikG builds religious discourse full of adaptability, flexibility, and tolerance in accepting differences.
The Protective Effect of Green Tea Extract on Alpha-amanitin Induced Hepatotoxicity
Authors: An Su Hwan , Sun Kyung Hoon , Hong Ran , Lee Byoung Rai , Park Yongjin
Published: June 2023

Purpose: Alpha-amanitin induces potent oxidative stress and apoptosis, and may play a significant role in the pathogenesis of hepatotoxicity. This study examined the mechanisms of α-amanitin-induced apoptosis in vitro, and whether green tea extract (GTE) offers protection against hepatic damage caused by α-amanitin (AMA) induced apoptosis in vivo. Methods: The effects of GTE and SIL on the cell viability of cultured murine hepatocytes induced by AMA were evaluated using an MTT assay. Apoptosis was assessed by an analysis of DNA fragmentation and caspase-3. In the in vivo protocol, mice were divided into the following four groups: control group (0.9% saline injection), AMA group (α-amanitin 0.6 mg/kg), AMA+SIL group (α-amanitin and silibinin 50 mg/kg), and AMA+GTE group (α-amanitin and green tea extract 25 mg/kg). After 48 hours of treatment, the hepatic aminotransferase and the extent of hepatonecrosis of each subject was evaluated. Results: In the hepatocytes exposed to AMA and the tested antidotes, the cell viability was significantly lower than the AMA only group. An analysis of DNA fragmentation showed distinctive cleavage of hepatocyte nuclear DNA in the cells exposed to AMA. In addition, the AMA and GTE or SIL groups showed more relief of the cleavage of the nuclear DNA ladder. Similarly, values of caspase-3 in the AMA+GTE and AMA+SIL groups were significantly lower than in the AMA group. The serum AST and ALT levels were significantly higher in the AMA group than in the control and significantly lower in the AMA+GTE group. In addition, AMA+GTE induced a significant decrease in hepatonecrosis compared to the controls when a histologic grading scale was used. Conclusion: GTE is effective against AMA-induced hepatotoxicity with its apoptosis regulatory properties under in vitro and in vivo conditions.
Prospective validation of an equation based on plasma cystatin C for monitoring the glomerular filtration rate in children treated with cisplatin or ifosfamide for cancer
Authors: Chatelut Etienne , Lambert Marie , Alonso Mathieu , Munzer Caroline , Zimoch Marie-Christine , Malard Laurence , Gambart Marion , Castex Marie-Pierre , Martins Carla , PASQUET MARLENE
Published: June 2023

We recently proposed an equation to estimate the glomerular filtration
rate (GFR) in children with cancer based on plasma cystatin C and serum
creatinine levels together with body weight (the “CysPed equation”).
The current clinical study reports a prospective evaluation of this
equation in 18 children treated by nephrotoxic chemotherapy. The CysPed
equation resulted in less bias and greater precision compared to two
equations previously proposed equations by Schwartz, with or without
plasma cystatin C. Moreover, the decrease in GFR due to chemotherapy was
clearly identified by the CysPed equation. This equation deserves to be
evaluated by other teams and routinely used in childhood cancer units.
Gilbert’s Syndrome Leads to Elevated Bilirubin after Initiation of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis
Authors: Patel Nidhi , Ansar Maria , Pham Anh , Thomsen Kelly , McKinzie Cameron , Polineni Deepika , Esther Charles , Brown Rebekah
Published: June 2023

Nine people with cystic fibrosis (pwCF) were found to have isolated
elevations in serum total bilirubin after starting
elexacaftor/tezacaftor/ivacaftor (ETI) that were associated with
Gilbert’s Syndrome. In longitudinal examination, total bilirubin levels
increased substantially after initiation of ETI without elevations in
liver transaminases in those with this syndrome. Because elevated
bilirubin levels in Gilbert’s Syndrome are benign, ETI was able to be
continued in these individuals. Genetic testing for this relatively
common syndrome should be strongly considered for pwCF experiencing
isolated hyperbilirubinemia after starting ETI, since appropriate
diagnosis may help pwCF avoid unnecessary interruption in this therapy
with significant health benefits in CF.
Factors influencing the consumers’ purchase intentions toward Organic food
Authors: Nasir Nimra
Published: June 2023

The fundamental drivers of sustainable consumer behavior are consumption ideals. This study examines the relationship between consumption values (functional, social, economic, and emotional), attitude toward buying, perceived behavioral control, and the intention to buy organic food by incorporating the theory of consumption approach. With a Google form survey, the data was collected from 156 organic food buyers in Karachi (Pakistan) because of limited resources. Using the PLS-SEM method, we discover that consumers’ intentions to buy organic food are significantly positively influenced by economic value, emotional value, social value, and functional value quality. The structural relationship between consumption values and the intention to buy organic food is further found to be significantly mediated by attitude toward purchasing. In contrast, the relationship between attitude toward purchasing and the intention to buy organic food was moderated by perceived behavioral control. According to our findings, promoting treatments that address attitudes toward purchases is a potential method to encourage persistent purchase intentions. These findings significantly impact how the organic food business develops based on consumer preferences.
The Bank of Indus: a strategic operational transformation
Authors: Butt Rehan Muzamil
Published: June 2023

The case describes how Khyber Bank saw compelling reasons to open branches in FATA, a part of the KPK province. Khyber Bank had only 2.5 months to open branches in FATA, where there was no concept of banking or operating banks in the area. The branches had to be operationalized by the end of November 2019; hence, this was a challenge that was to be encountered by Khyber Bank. In the underdeveloped new zone of FATA, where there was no such idea of the banking system and financial services, recruiting, residence, security, finance, awareness, economic, and infrastructural concerns were real. Despite having the advantage of being the first to market, the bank nevertheless had to ensure that all of its branches were self-sustaining within the first few years of operation. The story was about internal operations and decisions, citizens’ involvement, and analytical study to evaluate the real-world reality of that specific zone. The case explores Khyber Bank’s problems while relocating its branches in FATA within 2.5 months and how they tried to overcome them.
BREAKAWAY : Combating Violence against Women and Girls through Soccer Video Game and Youth Camps
Authors: Wang Hua , Choi Ji Hye , Wu Yishin , DeMarle Ann
Published: June 2023

Violence against women/girls (VAWG) causes severe harm to victims and societies. Early interventions among youth are crucial. BREAKAWAY is an online, narrative-based, role-playing soccer game purposefully designed to educate youth worldwide about VAWG. It is the first to adapt the Sabido methodology of entertainment-education in games for social change. In 2013, BREAKAWAY youth camps were held in El Salvador, a Central American country among the highest per capita rates of femicide in the world. Event-based time diary, participatory sketching, gamification strategies, and Facebook Insights were used for assessment. We found it effective to use role modeling and narrative engagement of the Sabido methodology in game design. Overall, the game and camp experience had a profound impact on the participants. They gained knowledge and skills about VAWG. They also reported positive attitude and initiation of behavior change toward gender equality. They demonstrated that experiential gameplay coupled with facilitated group discussions could be helpful in addressing complex social issues. Our quantitative analysis suggested potential empowerment for girls and openness to change for boys. The BREAKAWAY Facebook page also had a surge of traffic and user interactions during and after the camps.
β-Cell Glucose Sensitivity to Assess Changes in β-Cell Function in Recent-Onset Stage 3 Type 1 Diabetes
Authors: Gitelman Stephen E. , Evans-Molina Carmella , Guolo Annamaria , Mari Andrea , Ferrannini Ele
Published: June 2023

Following a diagnosis of type 1 diabetes (T1D), persisting C-peptide secretion leads to improved glycemic control and outcomes. Residual β-cell function is often assessed with serial mixed-meal tolerance tests, but these tests do not correlate well with clinical outcomes. Herein, we instead use β-cell glucose sensitivity (βGS) to assess changes in β-cell function, incorporating insulin secretion for a given serum glucose into the assessment of β-cell function. We evaluated changes in βGS in individuals enrolled in the placebo arm of 10 T1D trials performed at diabetes onset. We found that βGS showed a more rapid decline in children, as compared with adolescents and adults. Individuals in the top quartile of βGS baseline distribution had a slower rate in loss of glycemic control time over time. Notably, half of this group were children and adolescents. Finally, to identify predictors of glycemic control throughout follow-up, we ran multivariate Cox models and found that incorporating βGS significantly improved the overall model. Taken together, these data suggest that βGS may be of great utility in predicting those more likely to have a more robust clinical remission and may be of use in design of new-onset diabetes clinical trials and in evaluating response to therapies.

Article Highlights

We undertook this study to better predict β-cell loss following type 1 diabetes diagnosis. We set out to answer whether β-cell glucose sensitivity (βGS) improves means to evaluate β-cell function postdiagnosis and whether βGS correlates with clinical outcomes. We found that βGS declines faster in children, subjects in the top baseline quartile of βGS exhibit slower β-cell decline (half are children), and incorporating βGS into multivariate Cox models for glycemic improves the model. The implications of our findings are that βGS predicts those likely to have robust clinical remissions and may help with clinical trials design.
First Use of Tapinarof Monotherapy for Seborrhoeic Dermatitis: A Case Report
Authors: Issa Naiem T. , Kaiser Michael
Published: June 2023

Abstract is missing (Short communication)
Nurses Performance Regarding Peripheral Cannulation among Neonate Khartoum State Hospitals (2020-2021)
Authors: Mokhtar Kawther Mohammed
Published: June 2023

Background: Peripheral intravenous cannula is most common vascular access device used to administer medication or fluid, cannulation may cause severe damage to small vein if the insertion not proper, therefore it need professional practitioner. The study aimed to assess nurses’ performance regarding peripheral cannulation for neonate in Khartoum state Hospitals, Sudan, in 2020. Material and Methods: Adescriptive cross sectional hospital based study design was used. Sample size consisted of 105 nurses; data collected using self- administered questionnaire and observational checklist, data analyzed by Statistical Package for Social Sciences (SPSS) uses standard deviation, T test mean and percentage Spearman correlation coefficient p value was less than 0.05.Ratability and validity of the scale was test by Cronbach’s Alpha and Spearman-Brown Reliability Coefficients Performance total scores (n = 32) Results: Showed that, (54.3%) of nurses were between 21-30 years, (67.6%) of nurses were master holders, (55.2%) of them attended training courses regarding neonatology. The mean of nurses’ performance about hand hygiene was 90.0%. The mean of nurses’ performance about use of Personal protective equipment was 96.6%. The mean of nurses’ performance about skin preparation was 92.2%. (37.1%) of nurses succeed to insert cannula after more than 3 attempts, 31.4 insert it from the second time, 18.1% from the first time, (62.9%) of nurses did not recorded the data. The overall mean of nurses’ compliance about peripheral cannulation was 68% Conclusion: The studies concluded that nurse’s performance regarding cannulation is high and there was lacking in their practice toward peripheral intravenous cannulation in some pediatric health settings and there is positive correlation between nurse’s level of education and their performances. The study recommended more training courses.
A Study to Assess the Knowledge Regarding Legal Aspects of Child Abuse among Care Takers of Children With A View to Develop an Information Pamphlet on Child Abuse in A Selected Hospital, Bangalore
Authors: Biji Blessy Susan
Published: June 2023

Child abuse or child maltreatment is any kind of physical, sexual or psychological maltreatment or neglect of a child or children, especially by a parent or other caregiver. The prevalence of child abuse globally is estimated up to 1 billion children aged between 2-17 years have experienced physical, sexual or emotional violence or neglect as per the statistics of 2020 by WHO. It is the responsibility of the caretakers to protect their child and be aware of all the legal aid which is available for children afflicted with child abuse. So the study was conducted with the objectives as follows: • To assess the knowledge of caretakers regarding legal aspects on child abuse. • To determine the association between knowledge regarding legal aspects of child abuse and selected demographic variables. A descriptive cross-sectional study was conducted among the caregivers of children below 15 years of age visiting paediatric OPD of SJMCH, Bangalore. A structured questionnaire was used to assess the knowledge regarding legal aspects of child abuse. The data was analysed by using descriptive and inferential statistics. In our study, only 4.2% of parents had good knowledge about the topic whereas 50.9% had moderate knowledge. Therefore, the researcher felt a strong need to educate and spread awareness to the parents regarding the topic of child abuse.
A Case Report of Osteoblastoma of Distal Femur: A Diagnostic Challenge
Authors: Parmar Jitendra
Published: June 2023

Osteoblastoma is uncommon benign bone tumor, representing approximately 1% of all primary bone tumor. The nidus of osteoblastoma is simulating to that of osteoid osteoma on histopathology and imaging, but it is larger in size. Osteoblastomas have a variable imaging appearance ranging from indolent to very aggressive, and many times difficult to differentiate from osteoid osteoma only based on imaging. A combination of thorough medical history, radiographic examination and clinical suspicion is at most important for differentiating osteoblastoma from osteoid osteoma. We present a case report of benign osteoblastoma of meta-diaphysis of distal femur in 15-year-old male child and histopathological confirmation.
Evaluation of Neonatal Resuscitation Knowledge and Procedures According to the “Helping Babies Breathe” (HBB) Program by Qualified Health Care Staff at the Sikasso Hospital Level in Mali
Authors: Cissouma Assetou
Published: June 2023

Introduction: Perinatal asphyxia is one of the leading causes of perinatal death. According to the WHO, two thirds of these deaths can be prevented with simple and effective interventions. The HBB (Helping Babies Breathe) program provides effective care for asphyxiant newborns regardless of the level of care. Objective: The objective of our work was to assess the knowledge of neonatal resuscitation equipment and procedures according to the HBB program by qualified nursing staff at the level of referral health structures in the Sikasso region of Mali. Methodology: This is a multicenter cross-sectional survey over a period of 4 months. It was carried out in two maternities and two referral neonatal units in Sikasso. The target population studied was made up of the nursing staff involved in the reception and care of newborns in the delivery room, in postpartum suites and in neonatal departments. Results: Eighty percent (112/141) of targeted caregivers were interviewed. More than half (44%) had more than 6 years of experience in neonatal care. Only 27% had received training in neonatal resuscitation including HBB. The most cited materials used for resuscitation were the mucus aspirator (82%), the ventilation bag (67%) and the heated table (60%). The bestknown resuscitation procedures were airway aspiration (82%), mask ventilation (60%), and hypothermia control (48%). Conclusion: Knowledge of newborn resuscitation remains very insufficient in the reference structures in Sikasso. It is necessary to implement a strategic plan for continuous training of staff with periodic monitoring in health structures.