bluuebunny/crossref_metadata_2025 huggingface dataset:
escola e eu
Authors: Cândido Renata Marcílio , Martins Edna
Published: March 2023

Os altos índices de trabalhadores informais que ocupam as ruas dos grandes centros urbanos têm sido um fenômeno historicamente ligado à pobreza e às desigualdades socioeconômicas que ampliam a vulnerabilidade social. Com base nisso, o artigo apresenta a experiência de pesquisa que investigou trajetórias de escolarização de jovens e adultos em situação de trabalho informal. A partir de metodologia qualitativa, utilizando procedimentos de histórias de vida por meio de entrevistas, buscou-se compreender os sentidos atribuídos por  trabalhadoras aos seus processos de escolarização. A análise dos dados indicou a ausência de vínculos entre as entrevistadas e os saberes e as culturas escolares, assim como a significação do fracasso escolar como algo individualizado com pouca ligação com o mundo da escola.
Microinsurance: A PRISMA-compliant systematic review of its regulatory-, subsidy-, demand- and supply-side determinants
Authors: Osifodunrin Edward A.
Published: March 2023

Guided by the holistic stance of the systems theory and motivated by the ultimate mission to enhance poor people’s access to formal microinsurance, the current study innovatively looked beyond reviewing only the determinants of the demand-side of formal microinsurance development (FMID), as narrowly portrayed in the extant literature reviews of Platteau et al. (2017) and Eling et al. (2014). Reviewing and optimally managing the determinants of other sides or dimensions of FMID (i.e., the subsidy-supply-regulatory sides) are also mission-critical for the governance and advancement of formal microinsurance. One hundred sixty-two (162) articles were systematically gathered and analysed using PRISMA (the preferred reporting items for systematic reviews and meta-analyses), with evidence that literature has focused mainly on the impact of various endogenous determinants, while exogenous determinants have been largely overlooked. Amongst 52 articles short-listed, “interest rate” was the only exogenous determinant ever empirically affirmed as a variable influencing FMID. Furthermore, “insurance literacy” and “innovation” were identified as the most investigated endogenous determinants on the demand- and supply-sides of FMID, respectively. The study also evinced the dearth of research in investigating the determinants of the subsidy- and regulatory-sides of FMID. Empirical games and natural experiments were the most probing and revealing methodologies, churning out innate/relational tendencies of research respondents and more interesting evidence than initially envisaged. The geographical research focus was majorly on Asia and Africa. The paper presents more literature gaps, coupled with guides for future policy and market governance.
Traditional Grazing Management Practices Affect Vegetation Dynamics in the Somali Pastoral Ecosystem of Ethiopia
Authors: Gebremedhn Haftay , Dejene Sintayehu , Tuffa Samuel , Tesfay Yayneshet , Adam Devenish
Published: March 2023

Pastoralist grazing management practices play a vital role in
maintaining rangeland productivity and biodiversity. However, the
degradation of rangelands and loss of ecosystem services have raised
concerns about the future of pastoralism as a form of land use. Despite
their importance, we have limited knowledge about the effect of
traditional grazing management practices on vegetation attributes, such
as species composition, richness, diversity, herbage biomass, and
density, and canopy cover. To address this knowledge gap, we studied the
changes in vegetation attributes under three traditional grazing
management practices in the Somali pastoral ecosystem of Ethiopia. We
found a significant difference in herbaceous and woody vegetation
attributes among the grazing management practices (p < 0.001).
Enclosures supported higher herbaceous species diversity and abundance
of desirable species, such as Chloris gayana, Chrysopogon aucheri,
Cynodon dactylon, and Themeda triandera, compared to open grazing and
browsing management sites. The herbage biomass was three times higher in
enclosures than in open grazing and twice higher than in browsing
management practices. However, browsing management practices supported
significantly higher levels of wood biomass, density, and canopy cover
than the other management practices. Our results suggest that
transitioning from open grazing to the enclosure and browsing management
practices can lead to higher plant productivity, which supports the
local pastoral economy in the Somali rangeland of Ethiopia. Thus,
dryland restoration programs should consider traditional indigenous
knowledge for ensuring the sustainability of future rangeland
productivity and biodiversity conservation.
Högskolepedagogisk utveckling och forskning. Gränsarbete kring ett kunskapsområde i universitetets hjärta. En kommentar till Wide samt Scheja och Bolander Laksov
Authors: Lindberg-Sand Åsa
Published: March 2023

Vid Örebro universitet anordnades våren 2021 för andra gången konferensen Forskning om högre utbildning. Ett tema för konferensen var utveckling av högskolepedagogisk forskning. Högre utbildning publicerar nu tre texter på detta tema som en fördjupad diskussion. De kan läsas var för sig eller tillsammans. Den första utgörs av Sverre Wides inledningsanförande från konferensen. Efter inbjudan från redaktionen har sedan Max Scheja och Klara Bolander Laksov, som professorer inom området, kommenterat Wides bild av vad högskolepedagogisk forskning är och kan vara, vilket utgör det andra bidraget. Slutligen inbjöd redaktionen även Åsa Lindberg-Sand att reflektera över relationen mellan högskolepedagogisk forskning och forskning om högre utbildning. Detta är hennes bidrag.
ENGLISH ABSTRACT
Higher education research and development: The boundary work framing a new educational practice at the heart of the university. A comment to Wide and Scheja & Bolander Laksov.
In spring 2021, Örebro University arranged the second Swedish conference for Research in Higher Education. One of the themes for the conference was the development of higher education studies as a specific branch of this research. Our journal, Högre utbildning, now publishes three contributions linked to this theme as in-depths essays. These may be read separately or together. The first consists of the introductory keynote from the conference, held by Sverre Wide. The team of editors then invited Max Scheja and Klara Bolander Laksov, as professors in this domain, to share their view of the nature of their branch of studies in higher education, in relation to the view put forward by Wide. Their contribution is the second one. Finally, the editors also invited Åsa Lindberg-Sand to share her reflections on the relationship between research in higher education and the development of studies in higher education.Below her contribution follows.
Awareness and attitudes of nurses of the Clinical center of the University of Sarajevo (ccus) towards the organization of palliative care
Authors: Terzo Nermina , Salihović Amela , Mahmutović Jasmina , Šljivo Enisa , Branković Suada , Eminović Ernela , Ovčina Amer
Published: March 2023

Introduction: The health system is one of the most complex systems in any country. According to the definition of the World Health Organization, the health caresystem includes health infrastructure that provides a spectrum of programs and services and provides health care to individuals, families and the community. A basichuman right is the right to health care, which includes health activities such as preventive, curative and palliative treatment. The organization of palliative medicineis necessary at all levels of health care.Aims: Situational analysis of the organization of palliative care in the Clinical Center of the University of Sarajevo. Examining the knowledge and approach of healthcareworkers in the process of providing palliative care at the Clinical Center of the University of Sarajevo. To examine the attitude of healthcare workers towards theAwareness and attitudes of nurses of the Clinical center of the University ofSarajevo (ccus) towards the organization of palliative care way palliative care is organized in the Clinical Center of the University of Sarajevo.Material and methods: 141 subjects employed at the Clinical Center of the University of Sarajevo (CCUS) participated in the research. The research is descriptiveand analytical. The results are presented in tables and graphs, chi-square and Fisher’s exact test were used for testing the significance of differences.Results: It was found that there are different knowledge, attitudes and approaches of the respondents regarding the way palliative care is organized, the provision ofservices and treatment in the hospital. The majority of respondents (64%) believe that palliative care should be organized in institutions for palliative care that meetthe conditions of the prescribed standards and criteria for palliative care.Conclusion: Significant differences were found in the knowledge, practice and attitudes of health workers about palliative care.
Development of a Framework for the Design and Implementation of Metaverse Class
Authors:   Korea Univ. Institute of Educational Research, Eom Mi-Ri , Kim Hyo-Jung , No Ah-Young , Sim Hee-Soo , Jin Seo-Yeon , Hyun Min-Young , Kim Sang-Hee
Published: March 2023

This study aims to clearly define the concept of metaverse class and develop a framework for the design and implementation of effective and efficient metaverse class. This study developed a basic framework through a literature review and interviews of 5 experts with experience in implementing metaverse class. After that, the content validity was conducted twice using CVI (Content Validity Index), and the development of the last version was completed by correcting and supplementing the content validity and expert opinions. The significance of this study is as follows: First, the concept of the metaverse class was defined from a pedagogical perspective. Second, a systematic framework for instructional design and implementation was presented by sufficiently reflecting the concept and characteristics of the metaverse class. Third, it can be used effectively and efficiently for the design and implementation of metaverse class regardless of the school level. This result is expected to serve as a practical guide for instructors who want to design and implement the metaverse class, and as a reflection and monitoring tool for the metaverse class.
The Role-playing Self: Virtual Ethnography Study of K-Pop Fans’ Idol-roleplaying and Self-identity in Twitter
Authors: Purwaningtyas Mashita Phitaloka Fandia , Oktara Tabina Azalia
Published: March 2023

The phenomenon of K-pop idol-roleplaying is on the rise in social media platform, particularly Twitter, among Indonesian youth. Idol-roleplaying refers to the activity where users or role-players create an account under the name and using the identity of their favorite idol, and then using it to interact with other role-players or other fans based on the image and plot that the role-player has determined. This phenomenon evokes question in regards to the identity performed by users or role-players under the veil of their idol’s identity, to the extent of how they interact with fellow role-players using that particular roleplay account. Hence, this research is significant in studying the idol-roleplaying phenomenon and the self-identity performance of fans, particularly in the context of Indonesian youth’s culture. This research is conducted with virtual ethnography method, involving eight role-players as informants. Initial findings highlight the performativity and identity play perform by role-players.
The clinical use of cannabidiol and cannabidiolic acid–rich hemp in veterinary medicine and lessons from human medicine
Authors: Ukai Masayasu , McGrath Stephanie , Wakshlag Joseph
Published: March 2023

The endocannabinoid system (ECS) is an integral neuromodulatory system involved in neuronal development, synaptic plasticity, and homeostasis regarding immunity, as well as brain and other physiological functions such as anxiety, pain, metabolic regulation, and bone growth. Cannabis is a plant that contains exogenous cannabinoids, which have the potential for profound interplay within the ECS as enzymatic inhibitors or receptor-mediated interactions. Activation of cannabinoid receptors leads to various intracellular signaling processes that are involved in cellular functions, but those interactions are diverse due to different affinities of each cannabinoid with relevant receptors. Among the exogenous cannabinoids, cannabidiol (CBD) has drawn attention due to its potential anticancer, antiangiogenic, anti-inflammatory, and antiseizure properties using in vitro and in vivo models. Although scientific evidence is limited in dogs, there appears to be cautious optimism regarding the utilization of CBD in conjunction with other therapeutics for a range of disorders. This review will primarily focus on current scientific research on the efficacy of CBD on seizure, anxiety, osteoarthritis, and atopic dermatitis, following a brief discussion of endo- and exogenous cannabinoids, ECS, their molecular mechanism, and potential side effects in veterinary medicine. Cannabinoid pharmacology and pharmacokinetics will be addressed in the companion Currents in One Health by Schwark and Wakshlag, AJVR, May 2023.
Candida Auris: What do We Know about the Most Enigmatic Pathogen of the 21st Century?
Authors: Bogut Agnieszka
Published: March 2023

Candida auris is a new fungal pathogen whose clinical significance has dramatically increased within recent years. Major issues related to this species include its rapid global spread and high epidemic potential, resilience and persistence in the hospital environment favoured by its resistance against certain disinfectants, horizontal transmission; possibility of persistent colonization, challenging laboratory identification based on conventional biochemical methods, multidrug resistance as well as the need for implementation of restrictive and expensive prevention and control measures. This review raises the above mentioned issues and compiles recent findings regarding this microorganism.
Lipopolysaccharide Pantoea Agglomerans and Atopic Dermatitis, Allergic Contact Dermatitis and Wound Healing
Authors: Kiecka Aneta , Szczepanik Marian
Published: March 2023

Lipopolysaccharide (LPS) is found in most Gram-negative bacteria and induces innate responses by binding to toll-like receptor 4 (TLR4). LPS isolated from Pantoea agglomerans species is an interesting issue. On the one hand, it is a risk factor for diseases such as wounds, abscess, bacteremia, pneumonia, urinary tract infections, septic arthritis, osteomyelitis and peritonitis. On the other, its health-promoting properties in atherosclerosis, Alzheimer’s disease, and osteoporosis are increasingly observed. Studies in humans and animal models show that LPS from P. agglomerans may have beneficial effects in the treatment of certain diseases. A huge challenge today is the prevention and treatment of skin diseases, including atopic dermatitis (AD), allergic contact dermatitis (ACD), and hard-to-heal wounds. Reports show that LPS from P. agglomerans may be useful in the treatment of skin diseases through its effects on the immune response. Studies show that LPS acts on Langerhans cells and leads to suppression of the allergic response.
Microbial Culture Collections and Microbiological Biobanks in the Context of New ISO Standards
Authors: Jaroszewska Ewelina , Nasiłowska Justyna , Sokołowska Barbara
Published: March 2023

In order to meet the growing needs of the world economy for biotechnology, culture collections must transform the way they operate from passive storage of microbial resources to active microbial resource centers whose services should go beyond the provision of microbes. The protection and conscious use of microorganisms aims to co-create a strategy for responsible and sustainable development, based on expert knowledge. This article deals with the subject of the recently developed panel of biobank-specific standards and the requirements that must be met by culture collections to transform into modern microbial biobanks.
Locals or Migrants? Strontium Isotope Analysis of Two North-South Oriented Great Moravian Graves
Authors:   Anthropos Institute, Moravian Museum, Zelný trh 6, 659 37 Brno, Czech Republic, Fojtová Martina , Vytlačil Zdeněk ,   Department of Anthropology, National Museum, Václavské náměstí 68, 115 79 Praha 1, Czech Republic,   Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Viničná 7, 128 43 Praha 2, Czech Republic
Published: March 2023

Migration has been used as one explanation for graves that deviate from the prevailing orientation and structure. Graves oriented in the north-south direction (i.e., deviating from the customary contemporary west-east orientation) at the Great Moravian and early medieval burial grounds of Přemyslid Bohemia and Moravia have attracted the attention of archaeologists for more than 100 years. These are most often interpreted as the graves of foreigners, based on the assumption that different burial rites indicate immigrants, but this has not been confirmed or refuted with empirical evidence. With this study, we have taken the first step towards testing the validity of this hypothesis. Samples from the dental enamel of the permanent molars of two individuals (H 16/2018 and H 18/2018) from the burial site “Na Valách”, located at the Great Moravian central site in Staré Město, were subjected to stable strontium isotope analysis. This analysis can help to assess the likelihood of mobility for these individuals. From the results obtained, it is not possible to confirm the non-local origin of either of the individuals, although in the case of H 16/2018 we may theoretically consider it. However, to definitively reject or confirm the hypothesis of a non-local origin of the people buried along the north-south azimuths, future analysis of a much larger sample size will be necessary.
Pathophysiology of Long-Term Post-Cesarean Complications: Novel Insight from Tissue Magnification Video-Recording
Authors:   New York University School Of Medicine, Antoine Clarel
Published: March 2023

Just over one century ago, the Cesarean operation was almost exclusively performed on a dead or dying mother to remove an infant, either dead or alive. During this time, it was avoided because of its high mortality rate [1].
Innovative Dynamics and Structural Changes in the Manufacturing Industry of the Volga-Ural Macro-Region
Authors: Preobrazhensky Yu. V.
Published: March 2023

The article discusses formation of an innovation system within the Volga-Ural macro-region. The scientific novelty of the work lies is the methodology for determining the flexibility of innovative component of the manufacturing industry in the region. The relevance of the research is determined by the need for a paradigm shift to the analysis of horizontal integration of regions, including in terms of innovation. Such integration will create prerequisites for an active flow of knowledge and the spread of innovations. The main properties of the territorial innovation system are formulated, including openness, innovation orientation, structural flexibility, and internal connectivity. The requirements for the functions and regional parameters in such a system are justified, and the advantages of large regions-subjects of the Russian Federation as innovative cores are emphasized.

The main research methods, in addition to structural and spatial analysis and synthesis, were the calculation of structural coefficients in the economy and scientific and applied sphere for the Volga-Ural macro-region (Orenburg, Penza, Saratov, Samara and Ulyanovsk regions and the Republic of Bashkortostan). In particular, we use the Ryabtsev index, the coefficient of specialization (per capita production), and the coefficient of the use of advanced production technologies. The article analyzes structural shifts in innovative production in the manufacturing industries of these regions in the period 2010– 2019. This tool allows us to study the degree of manufacturing flexibility of the RF subjects of the Volga-Ural macro-region and the dynamics of their innovative development (ascending or descending) as well as the degree of its co-directionality.

The analysis shows heterogeneity of the macro-region in economic and innovative terms. The regions that differ most from others in the structure of the innovation industry are identified (Bashkortostan and the Orenburg region). It is shown that the most positive dynamics is typical of Bashkortostan whereas a number of other regions face innovation degradation. The article considers the prospects of Ulyanovsk and Samara regions as generators of knowledge and innovation in the macro-region.

The results of the study can be used in business (identifying the region with the most flexible economic structure as an innovative attractive one) and in state spatial planning (determining the composition of macro-regions). Such research is relevant for any macro-regions in the country.
Problems of Implementing National Projects at Municipal Level
Authors: Goryachenko E. E. , Malov K. V.
Published: March 2023

The article analyzes the problems of implementing national projects at the municipal level. Based on the materials of the next wave of the annual expert survey of heads of municipalities conducted by the authors in March-April 2020 as part of monitoring the socio-economic situation in Russian municipalities. The author assesses the current situation, shows its distinctive features and trends in the context of the dynamics of the last decade, identifies the main problems that arise in municipalities in modern conditions during the implementation of national projects and possible ways to solve them. It is shown that serious barriers to the implementation of national projects at the municipal level, in addition to the wellknown problem of financial support, are the imperfection of the regulatory framework, insufficient methodological and information support, organizational difficulties, as well as personnel problems that significantly complicate the implementation of specific activities. The main obstacles to the implementation of national projects at the local level are weak coordination, inconsistency of actions of various bodies, centralization of managerial influences, as well as limited and insufficient certainty of the powers of local self-government bodies in the implementation of national projects. It is concluded that it is necessary to improve the mechanisms of interaction between regional and local authorities, aimed at significantly increasing the role assigned to local governments in the implementation of national projects. An important basis for decision-making in the development and evaluation of the effectiveness of national projects should be taking into account the opinions of heads of municipalities on the basis  of sociological monitoring of the socio-economic situation and evaluating the effectiveness of measures taken to resolve problems at the municipal level.
Cluster Project Risk Control System
Authors: Vyzhitovich A. M.
Published: March 2023

Almost any organization can be exposed to risks in cluster interactions. The variety of external and internal factors leads to various adverse consequences. Today, many organizations involved in cooperation within cluster projects and interacting with external counterparties face a serious problem of how to increase the efficiency of their risk control systems. The aim of the research is to formulate and develop the approaches for monitoring the relationship of the cluster’s participants by interested parties on implementing regional cluster policies. The study addresses the development of methodical approaches for improving control measures to identify and manage the specific risks of a separate cluster when implementing regional cluster policy, changes in legislation and the current economic situation, and determination of factors influencing data validity and reliability. The article identifies individual risks of business cooperation projects, specifies methodical approaches for assessing counterparties, given the clarified data validity, and develops a roadmap to improve the control system in a problem solving format. The work has theoretical and practical significance for corporate and state control of cluster cooperation. The use of new control mechanisms and systems is sure to reduce negative impacts of cluster project risks.
The Study on Knowledge Self-Organization and Technological Structure of the Russian Regions by Means of Kohonen’s Self-Organizing Maps
Authors: Zabolotsky A. A.
Published: March 2023

The article proposes a novel model for assessing the quality of technological development which differs from the similar spillovers by introducing a fundamentally new parameter of knowledge selforganization. Unlike spillovers measuring financial R&D flows, knowledge spillover measures structural similarities presented in patents, articles and other quantized units. Being the results of the reactions on the emergence of technological tasks and absorbing new technologies themselves, patents reflect real industrial picture of distribution of new technologies in any particular area. Implementation of selforganizing neural maps unveiled strong self-organized structural patterns distributed across the Russian Federation which were undetectable by means of conventional spatial econometric methods. Furthermore, neural maps exposed serious drawbacks of the Russian knowledge flow system, which is a drastic lack of flow in several high tech areas such as biotechnology. Self-organization indicator can be applied for evaluation of Megascience projects or other programs on both regional and federal levels.   The structure of regional technologies based on 24 technological areas is studied and mapped on neural model, thereby it has been hypothesized that self-organization has an effect on qualitative processes of technological development. The study presents validation model of this hypothesis based on Kohonen’s self-organizing maps. Enhancement of this model on the further spatial studies is shown. Knowledge self-organization variable is developed to indicate technology integration and emergence.
Basic principle from electrospray ionization to soft ionization mass spectrometry and development of ion source
Authors: luo jiehong
Published: March 2023

Since the electrospray phenomenon was discovered, there is still an unsolved mystery about the prinple of generating charged analyte in the soft ionization phenomenon which represented by ESI. Scientists have described this process from different perspectives, but current theories still can not explain many experimental phenomena. At the same time, the slow development of the theory restricts the design and development of ion source, making it encounter many bottlenecks from the laboratory to commercialization. In this paper, the principle of electrospray ionization and soft ionization mass spectrometry is briefly introduced, and the application of ion migrate and transport mechanism is discussed, all are expected to be used in the development of ion sources.
A Resource to Support Decolonization of the Undergraduate Chemistry Curriculum
Authors: Uleanya Ogochukwu Kelechi , Furfari Sam , Jones Leonie C. , Selwe Kgato P. , Milner Amelia B. , Dessent Caroline E. H.
Published: March 2023

In our taught chemistry curricula, the majority of individuals who are used to illustrate historical aspects of chemistry topics are white western chemists. Decolonizing the undergraduate chemistry curricula is increasingly recognized as an important step towards developing a more inclusive higher-education environment for students from minoritized ethnic backgrounds. Here, we provide the first openly accessible resource that can be used to decolonize an undergraduate chemistry course. In particular, the resource provides examples of both individual scientists and groups that can be used to illustrate chemistry teaching, and hence provide role model examples of scientists from different cultures. The resource presented provides a significant body of examples for chemistry lecturers to use as they begin working towards decolonizing their curricula.
Novel ultrahard carbon allotropes from crystal chemistry and first principles: rhombohedral ene-C21 and yne-C24
Authors: Matar Samir F. , Solozhenko Vladimir L.
Published: March 2023

Rhombohedral ene-C21 and yne-C24, characterized by the presence of C=C and C=C bonds, respectively, inserted into the 9R diamond polytype C18, are proposed as novel ultrahard carbon allotropes from crystal chemistry and first principles. Like 9R C18, they belong to the cfe topology characteristic of layered SiC polytypes. With ultrahard properties approaching those of diamond and lonsdaleite, ene-C21 and yne-C24 are dynamically stable with phonon signatures identifying C=C and C=C high frequency vibrations similar to molecular allene and acetylene. The electronic band structures correspond to insulating C18, metallic ene-C21 and semiconducting yne-C24.
Increasing the robustness of SIFT-MS volatilome fingerprinting by introducing notional ion concentrations
Authors: Benchennouf Amina , Corion Matthias , Dizon Angelica , Zhao Yijie , Lammertyn Jeroen , De Coninck Barbara , Nicolaï Bart , Vercammen Joeri , Hertog Maarten
Published: March 2023

Selected-ion-flow-tube-mass-spectrometry (SIFT-MS) is an analytical technique for volatile detection and quantification. SIFT-MS can be applied in a ‘white box’ approach, measuring concentrations of target compounds, or as a ‘black box’ fingerprinting technique, scanning all product ions during a full scan. Combining SIFT-MS full scan data acquired from multi-batches or large-scale experiments remains problematic due to signal fluctuation over time. The standard approach of normalizing full scan data to total signal intensity was insufficient. This study proposes a new approach to correct SIFT-MS fingerprinting data. In this concept, all the product ions from a full scan are considered individual compounds for which notional concentrations can be calculated. Converting ion count rates into notional ion concentrations accounts for any changes in instrument parameters. The benefits of the proposed approach are demonstrated on three years of data from both multi-batches and long-term experiments showing a significant reduction of system-induced fluctuations providing a better focus on the changes of interest.
Discovery of Ag as an Active and Selective Catalyst for the Electrochemical Synthesis of Urea from NO3- and CO2 with ~100 % Selectivity at -100 mA/cm2 Urea Current Density
Authors: Kani Nishithan , Goyal Ishita , Olusegun Samuel , Bhawnani Rajan , Gauthier Joseph , Singh Meenesh
Published: March 2023

The current method to synthesize urea is highly energy intensive and has a massive carbon footprint. Electrochemical synthesis of urea from NO3- and CO2 is an attractive and sustainable way as renewable energy can be used to synthesize green urea at ambient conditions by utilizing the waste NO3- and CO2 from the air or flue gas. In this work, we conduct a thorough catalytic screening on various metal-based catalysts. ~100 % urea Faradaic efficiency and ~-100 mA/cm2 of urea current density is observed at -1.2 V vs. RHE when Ag GDE is used. FTIR analysis further confirms the formation of urea and the presence of *CO intermediates. The excellent kinetics and selectivity towards urea on Ag are explained by a combination of facile first and second C-N bond formation steps and an endergonic (ΔG > 1.5 eV) formamide (HCONH2) formation step from *CONH2 from our DFT studies.
Discovery of Potential GSK-3β Allosteric Modulators for Alzheimer’s Disease
Authors: Silva Guilherme Martins , Alves Vinicius Medeiros , Gomes Suzane Quintana , Hochuli Joshua Earl , Muratov Eugene , Tropsha Alexander , Silva Carlos Henrique Tomich Paula
Published: March 2023

Glycogen Synthase Kinase-3 beta (GSK-3β) is a validated target-enzyme associated with Alzheimer’s Disease (AD). Usage of allosteric inhibitors of this enzyme represents a valid and promising therapeutic strategy due to their selective and subtle modulation, with a low probability of producing side effects. Nonetheless, only a few GSK-3β allosteric modulators with limited binding affinity have been uncovered so far and published in the public domain. Previous Virtual Screening (VS) studies have not considered such mechanism of action and did not achieve chemical diversity. Therefore, we applied two orthogonal VS workflows by means of shape-based similarity, QSAR, docking, and ADMET filters to select new and diverse GSK-3β allosteric inhibitors. Obtained hits have shown enhanced structural diversity and preliminary results as GSK-3β allosteric inhibitors according to in vitro assays. Furthermore, their GSK-3β allosteric inhibition were analyzed by blind docking and pocket coverage studies. These hits can be employed as template molecules for the discovery of more potent inhibitors, with the aim to expand the chemical space of GSK-3β allosteric modulators as promising agents in AD.
Implementing electronic signatures of graphene and hexagonal boron nitride in twisted bilayer molybdenum disulfide
Authors: Arnold Florian M. , Ghasemifard Alireza , Kuc Agnieszka , Heine Thomas
Published: March 2023

Angeli and MacDonald reported a superlattice-imposed Dirac band in twisted bilayer molybdenum disulphide (tBL MoS2) for small twist angles towards the R_h^M (parallel) stacking. Using a hierarchical set of theoretical methods, we show that the superlattices differ for twist angles with respect to metastable R_h^M (0°) and lowest-energy H_h^h (60°) configurations. When approaching R_h^M stacking, identical domains with opposite spatial orientation emerge. They form a honeycomb superlattice, yielding Dirac bands and a lateral spin texture distribution with opposite-spin-occupied K and K’ valleys. Small twist angles towards the H_h^h configuration (60°) generate H_h^h and H_h^X stacking domains of different relative energies and, hence, different spatial extensions. This imposes a symmetry break in the moiré cell, which opens a gap between the two top-valence bands, which become flat already for relatively small moiré cells. The superlattices impose electronic superstructures resembling graphene and hexagonal boron nitride into trivial semiconductor MoS2.
Unveiling the Configurational Landscape of Carbamate: Paving the Way for Designing Functional Sequence-Defined Polymers
Authors: Perez Mellor Ariel F. , Brazard Johanna , Kozub Sara , Bürgi Thomas , Szweda Roza , Adachi Takuji B. M.
Published: March 2023

Carbamate is an emerging class of polymer backbone for constructing sequence-defined, abiotic polymers. It is expected that new functional materials can be de novo designed by controlling the primary polycarbamate sequence. While amino acids have been actively studied as building blocks for protein folding and peptide self-assembly, carbamates have not been widely investigated from this perspective. Here we combined infrared (IR), vibrational circular dichroism (VCD) and nuclear magnetic resonance (NMR) spectroscopy with density functional theory (DFT) calculations to understand the conformation of carbamate monomer units in a non-polar, aprotic environment (chloroform). Compared with amino acid building blocks, carbamates are more rigid, presumably due to the extended delocalization of π-electrons on the backbones. Surprisingly, cis configurations can be energetically stable for carbamates while peptides typically assume trans configurations at low energies. This study lays an essential foundation for future developments of carbamate-based sequence-defined polymer material design.
Into the Dynamics of Rotaxanes at Atomistic Resolution
Authors: Leanza Luigi , Perego Claudio , Pesce Luca , Salvalaglio Matteo , von Delius Max , Pavan Giovanni M.
Published: March 2023

Mechanically-interlocked molecules (MIMs) are at the basis of artificial molecular machines and are attracting increasing interest for various applications, from catalysis to drug delivery and nanoelectronics. MIMs are composed of mechanically-interconnected molecular sub-parts that can move with respect to each other, imparting these systems innately dynamical behaviors and interesting stimuli-responsive properties. The rational design of MIMs with desired functionalities requires studying their dynamics at sub-molecular resolution and on relevant timescales, which is challenging experimentally and computationally. Here, we combine molecular dynamics and metadynamics simulations to reconstruct the thermodynamics and kinetics of different types of MIMs at atomistic resolution under different conditions. As representative case studies, we use rotaxanes and molecular shuttles substantially differing in structure, architecture, and dynamical behavior. Our computational approach provides results in optimal agreement with available experimental evidence and a direct demonstration of the critical effect of the solvent on the dynamics of the MIMs. At the same time, our simulations unveil key factors controlling the dynamics of these systems, providing submolecular-level insights into the mechanisms and kinetics of shuttling. Reconstruction of the free-energy profiles from the simulations reveals details of the conformations of macrocycles on the binding site that are difficult to access via routine experiments and precious for understanding the MIMs’ behavior, while their decomposition in enthalpic and entropic contributions unveils the mechanisms and key transitions ruling the intermolecular movements between metastable states within them. The computational framework presented herein is flexible and can be used, in principle, to study a variety of mechanically-interlocked systems.
Using Blended Learning in the EFL Classroom During the Covid-19 Pandemic in Indonesia: A Narrative Inquiry
Authors: Wahyuningsih Sri , Afandi Muhamad
Published: March 2023

With the rapid development of information and communication technologies, some learning platforms have been used in the educational setting, particularly during the Covid-19 pandemic. This paper reports on blended learning or online and face-to-face learning practices viewed from lecturers and students’ perspectives at an Indonesian higher education institution. To capture the participants’ experiences, a narrative inquiry approach was adopted to the scope of blended learning in the English as a foreign language (EFL) classroom. In gathering the data, narrative interviews were used with four lecturers and four students. The findings reveal that the EFL lecturers used various online learning platforms in blended learning classes. Furthermore, both the EFL lecturers and students provided positive responses regarding blended learning. However, challenges were highlighted in the process of its implementation. These challenges include limited time allocation, poor internet connection, and students’ self-study unawareness. This paper highlights the need to reschedule proper time allocation, design the best teaching methods and materials in blended learning, provide the best internet connection, and encourage student motivation in blended learning.
Genetic alterations in azoospermia patients may reveal potential biomarkers for male infertility: A bioinformatic study
Authors: Aras-Tosun Duru
Published: March 2023

Background/Aim: Azoospermia is defined as the absence of sperm in semen and is one of the most common causes of male infertility, with a prevalence of 10-15% in infertile men. Conventional methods for semen analysis do not provide a clear understanding of the etiology of azoospermia. Although testicular biopsy may exclude obstructive cases, non-obstructive azoospermia (NOA) treatment is limited due to a limited understanding of the underlying molecular mechanisms. Analysis of genetic alterations in azoospermia patients compared to the fertile population may be a valuable tool for determining diagnostic biomarkers for male infertility. This study aims to use bioinformatic tools to determine the top candidates in certain pathways altered in azoospermia.
Methods: Expression data (GSE108886) of the differential testicular transcriptome in patients with NOA was selected from the Gene Expression Omnibus (GEO) database. Testicular RNA was harvested from azoospermia patients (n=11) and healthy controls (n=1, pooled sample). The differentially expressed genes (DEGs) were examined using GEO2R software. Biological pathways were identified through the Kyoto Encyclopedia of Genes and Genomes (KEGG). Construction of the protein network and detection of hub genes were conducted in the STRING database. Data validation was performed via ELISA assay for the FOXO3 gene in obstructive and NOA patients. Significance was set at P-value <0.05.
Results: In NOA patients, 2115 genes were upregulated, and 1753 genes were downregulated compared to the control group. Ninety-one genes involved in spermatogenesis were downregulated. KEGG analysis revealed that the glucagon signaling, AMPK signaling, insulin and estrogen signaling, and oocyte meiosis pathways were upregulated, while the regulation of actin cytoskeleton, MAPK signaling pathway, focal adhesion, and chemical carcinogenesis – reactive oxygen species pathways were downregulated. Downstream genes with the highest score were PSMA4, PSMA6, PSMC1, PSME4, and UBA52, which are responsible for the ubiquitin-dependent protein degradation. The top hub genes with increasing expression were RPS18, RPS2, and RPS4X
Conclusion: Although hub genes selected within the altering pathways may serve as a diagnostic tool for NOA, further validation of the presented data is necessary, as protein-protein interactions may not reflect alterations in gene expression in vivo.
The Influence of Cost Leadership Strategy, Difference and Focus on the Performance of the Company at PT. Pwi
Authors: Restiana Ina
Published: March 2023

The purpose of this study is to determine the effect of cost leadership strategy, differentiation strategy and focus strategy on company performance. The case study in this study was taken from PT. PWI, which is a manufacturing company engaged in the production of shoes and footwear. The population taken in this study, namely the employees of PT. PWI with a sample of 96 respondents who work within the scope of PT. PWI.

The dependent variable (Y) in this study is company performance, while the independent variable (X) includes: Cost advantage strategy (X1), Differentiation Strategy (X2) and Focus Strategy (X3). Data analysis method using path analysis with IBM SPSS statistics 16 program which is fully carried out by the author and also related parties. The results of this study indicate that the cost advantage strategy, differentiation strategy and focus strategy have a positive and significant impact on company performance. The differentiation strategy is the most influential strategy compared to the other two strategies.
A interação do homem com o benzopireno e sua relação com a carcinogênese .
Authors: Lobato Carlos Emanuel , Barbosa Ana Beatriz , Borges Anthony Felipe Morando , Ferreira Leonardo Neres , Rocha Lucas Matheus Silva Da , Pereira Rafael dos Santos , Menegheti Roney Ricardo , Trevisan Vinícius Freitas , DECHECHI THAYNARA KNOPIK , Custódio Thalyta , Ferreira Thiago Rios , Ceranto Daniela de Cassia Faglioni Boleta
Published: March 2023

Introdução: O benzo(a)pireno (BaP) é um composto do grupo dos hidrocarbonetos policíclicos aromáticos (HPAs), formado pela queima incompleta de material orgânico. É uma classe essencial de contamina
LGPD: O PÚBLICO E O PRIVADO NA CONTEMPORANEIDADE
Authors:   , Bizzarro Mariucha Magrini Neri
Published: March 2023

Com o advento da tecnologia, mais especificamente a internet, o mundo globalizado tornou-se mais acessível a todos, sem adentrar as diferenças sociais e econômicas. Não há como negar que tais ferramentas estão disponíveis a um número expressivo da população e traz muitas facilidades, que vão desde a execução de uma compra com um simples “clique”, à disponibilidade de informações de serviços, e por que não dizer, o acesso à vida e dados de cada pessoa. Com a expansão das redes sociais, por exemplo, a proteção à individualidade, privacidade e intimidade de cada indivíduo também se mostrou ameaçada, resultante da informatização dos meios de comunicação, e, consequentemente, das relações sociais, em que o usuário passa a ser sujeito de direito de uma relação virtual e efêmera. Daí dizer que existe uma tênue, “líquida” e frágil separação entre o que é de domínio público e o que é de domínio privado, no que diz respeito aos dados de cada indivíduo. A partir disso, o Marco Civil da Internet e a LGPD foram criadas no Brasil e passaram a regular como tais dados poderiam ser protegidos. Nesse caminho, buscou-se analisar as leis relacionadas para respaldar os indivíduos, solucionando conflitos originários de relações jurídicas virtuais.
X Encontro Científico do Grupo Pesquisas & Publicações - GPs; II Encontro Binacional Científico da FICS Brasil - Paraguai
Authors: Pinto Ricardo Figueiredo , Pinto Victória Baía
Published: March 2023

Em apenas dois anos e nove meses este é o décimo primeiro e-book que registra os encontros do Grupo de Pesquisas & Publicações – GPs no momento em que se realiza o X Encontro Científico do GPs, em parceria com a editora Conhecimento & Ciência – C&C que no próximo mês de abril completará vinte e três anos em atividades ininterruptas.

Neste e-book trazemos importantes contribuições fruto das produções dos graduandos do FormaPará em educação física e de concluintes do curso de graduação em Educação Física da Universidade do Estado do Pará campus III, dos mestrandos e doutorandos e de concluintes de cursos de mestrado e doutorado da Faculdade Interamericana de Ciências Sociais de Assunção do Paraguai – FICS. Além de docentes do curso de graduação em Educação Física da Universidade do Estado do Pará-GEDF da UEPA.

O e-book contém 16 artigos de pesquisas concluídas, 2 relatos de experiências e 8 banners todos no formato de capítulo totalizando 27 capítulos em 319 páginas.

Alguns capítulos bem como os banners deste e-book também serão apresentados no X Encontro Científico do GPs e II Encontro Binacional Científico da FICS Brasil - Paraguai no formato presencial em comunicação oral oportunizando um contato direto entre autores e leitores sobre as publicações.
Convidamos a todos a lerem o e-book e aproveitarem o máximo dos conteúdos aqui disponibilizados. Boas leituras a todos.

Os organizadores
Adaptation of the Love–Hate Scale for Sports Fans into Turkish: A validity and reliability study
Authors: KURAL Sercan , OZBEK Oguz , GURBUZ Bulent
Published: March 2023

Introduction: This research has been conducted so it can help to understand the feelings of love and hatred towards the opposing team and their supporters of football club fans and to determine and control the fans’ aggression. Objective: This study aims to adapt the Love–Hate Scale for Sports Fans (LHSSF) to the Turkish context to evaluate the fanatic (love and hate) feelings of football fans. Methods: The study groups consisted of 205 football fans aged 18–58 years (mean age = 30.11). The original version of the scale consists of seven items and two sub-dimensions. To test the construct validity of the scale, exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted, and internal consistency coefficients for the reliability of the scale were calculated. Results: According to the EFA result, the scale consisted of two sub-dimensions. In addition, the Confirmatory Factor Analysis was tested. In the performed analyses, the χ2/df, GFI, AGFI, CFI, IFI, SRMR and RMSEA goodness-of-fit indices were examined. The obtained values indicate that the fit indices are at a good fit level. Conclusions: The study reached significant findings indicating that the LHSSF adapted to the Turkish culture for Sports Fans can be used as a valid and reliable measurement tool in measuring love and hate levels among fans.