bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Amaliyah Ubudiyah dalam Membentuk Karakter Religius di Madrasah Aliyah Swasta Pesantren Temulus
Authors: Huda Muhamad Bahrul , Muasomah Luluk , Sadiran Sadiran
Published: June 2024

This research aims to provide a detailed description of how the amaliyah ubudiyah program is implemented at the MA Pesantren Temulus in the Ngawi area to influence the religious character of students. This research uses a descriptive qualitative approach. Data was collected through interviews, observation, and documentation. Bearing in mind the conclusions of this research, the Amaliyah Ubudiyah character formation program at the Temulus Islamic Boarding School begins with classroom learning using materials relevant to the course outline, syllabus, and RPP and continues with implementation through reflection. 5S (Sapa et al.) is fostered through the Amaliyah Ubudiyah program, as is appropriate clothing (neat, clean, covering the private parts), duha (prayer), reverence for predecessors, heroes, and religious figures, and reading. Friday Koran, Friday cleaning, PHBI, closing class prayer, congregational prayer during the day, keeping the school clean, and obeying the rules.
Pengaruh Metode Mind Mapping terhadap Hasil Belajar Bahasa Indonesia pada Materi Menulis Cerita Pendek Kelas V di SDN Mangunharjo 3
Authors: Lestari Sri , Septianingrum Kartika , Chaeroh Miratu
Published: June 2024

This study delves into the impact of employing the Mind Mapping technique on the proficiency of fifth-grade students in crafting short stories within the Indonesian language curriculum at SDN Mangunharjo 3 Ngawi. Employing a quantitative approach, the research adopts the True Experimental Design format. This experimental method meticulously assesses the influence of an independent variable (the treatment) on a dependent variable (the outcome) under controlled circumstances. With a focus on sample representation, all participants partake as respondents, utilizing a saturated sampling technique. The findings underscore a notable enhancement in students' narrative composition skills when utilizing the Mind Mapping technique, as evidenced by the Paired Sample t-Test analysis. The statistical analysis reveals a significant disparity, as indicated by the sig value (2-tailed) of 0.003, falling below the threshold of 0.005. Consequently, the null hypothesis (H0) is refuted, while the alternative hypothesis (Hadi) is validated, affirming the significant influence of Mind Mapping in this instructional context. So the conclusion of this research is that the experimental group as a treatment group used the mind mapping method more effectively.
Pengaruh Blended Learning terhadap Motivasi Belajar dengan Digital Literacy Sebagai Variabel Mediasi
Authors: Fitri Anisa , Shohib Muhammad Wildan , Maksum Muh. Nur Rochim
Published: June 2024

Motivation is the main key to the success of the education and teaching process. Therefore, it is necessary to explore more deeply what are the important factors in fostering learning motivation. Learning motivation can be grown through things that are related or directly related to student interactions on campus, such as the friendship environment, digital literacy, or the learning methods used. The purpose of this study is to determine the effect of Blended Learning on Learning Motivation and the effect of Digital Literacy as a mediating variable between the independent variable and the dependent variable. In addition, this research is expected to add insight in the field of education in order to improve things that can affect learning motivation. This type of research is field research and uses quantitative methods. This study involved 100 respondents from Islamic Religion students at Muhammadiyah University of Surakarta. The results of this study indicate a positive and significant influence between Blended Learing on Learning Motivation, and also a positive and significant effect of the influence of Digital Literacy as a mediating variable between the independent variable (Blended Learning) and the dependent variable (Learning Motivation).
Metafora Korupsi dalam Bahasa Indonesia di Portal Berita Daring
Authors: Amir Johar , Anwar Alifia Afdani , Saleh Muh.
Published: June 2024

The purpose of this study is to describe: (1) categorization of corruption metaphors in Indonesian on online news portals, (2) conceptual mapping of corruption metaphors in Indonesian on online news portals. This type of research is qualitative research. Researchers categorize metaphors using embodiment theory, which is the theory of uniting physical experience with human cognition proposed by Lakoff and Johnson. The results of the study show that there are seven categories of corruption metaphors in Indonesian on online news portals. The seven categorizations are corruption as a journey, corruption as a power, corruption as food, corruption as an enemy, corruption as a plant, corruption as a disease, and corruption as an object. In addition to these categories, there are also subcategories of corruption as power, namely corruption as natural power and corruption as psychological power. Then, it was also found that there were also subcategories of corruption as objects, namely corruption as a building and corruption as a tool, conceptual mapping of corruption metaphors in Indonesian ahasa on online news portals has been carried out in the categories of corruption as a journey, corruption as a force with subcategories of natural power and psychological power, corruption as food, corruption as an enemy, corruption as a plant, corruption as a disease, and corruption as an object with a subcategory of buildings and tools. All of these categories have been equipped with a conceptual mapping model which is shown by the semantic characteristics mapped between the target domain and the source domain along with explanations.
Peran Media Sosial dalam Kesantunan Berbahasa Siswa di Lingkungan SMA Negeri 1 Seririt
Authors: Pradnyani I Gusti Ayu Putu , Rasna I Wayan , Putrayasa Ida Bagus
Published: June 2024

This study aims to explain  the role of WhatsApp social media in students' language politeness, violations of the principle of student language politeness and students' use of language in association in the environment of SMA Negeri 1 Seririt. The design of this study is qualitative descriptive. This research uses observation, interview, documentation and record methods. The data analysis techniques of this research are, data collection, data reduction, data presentation, and conclusion drawn. The results of the study showed that there was a tendency to use emoticons/emojis intensively, shortcomings in the use of punctuation and the use of informal language with abbreviations or slang on WhatsApp social media. There are 20 types of data classified as violations of the principle of politeness in Leech which include violations of the maxim of wisdom, maxim of generosity, maxim of appreciation, maxim of simplicity, maxim of compatibility and maxim of sympathy. There are forms of students' use of language in school from the choice of words, sentence structure, and different levels of formality.
Comparative Nursing and Midwifery Regulatory Analysis: Ghana, South Africa, Kenya and Liberia in Context
Authors:   Former Registrar, Nursing and Midwifery Council of Ghana, Accra, Ghana, Nyante Felix , Oywer Elizabeth O. ,   Former Registrar/CEO at Nursing Council of Kenya, Nairobi, Kenya, Vasuthevan Sharon ,   Education Executive, Life Healthcare Group, Johannesburg, South Africa, Kpangbala-Flomo Cecelia C. ,   Registrar/Executive Secretary of the Liberian Board for Nursing and Midwifery, Monrovia, Liberia, Blankson Sophia ,   Director of Nursing Services, Cape Coast Teaching Hospital, Cape Coast, Ghana, Addy Alfred ,   Vice Principal, Assinman Nursing and Midwifery Training College, Fosu, Ghana, Akuffo Ebenezer Aboagye ,   Deputy to the Head of Health Training Institutions, Ministry of Health, Accra, Ghana, Mensah George Benneh ,   Chief Researcher, EGRC Ghana Limited, Cape Coast, Ghana
Published: June 2024

This comparative analysis examines the nursing and midwifery regulatory frameworks of Ghana, South Africa, Kenya, and Liberia to identify strengths, weaknesses, and areas for improvement. The analysis reveals that while Ghana and South Africa have relatively comprehensive and up-to-date frameworks, Kenya and Liberia face challenges related to the scope and currency of their legislation and the effectiveness of their regulatory bodies.
Clinical characteristics and outcomes in cancer patients affected by COVID-19: a study from a Peruvian cancer center
Authors: Ruiz Rossana , Morante Zaida , Namuche Fernando , Arbizu Angela , Flores Claudio , Vallejos Carlos , Young Frank , Aguilar Alfredo , Castillo Luis , Montenegro Paola , Seas Carlos
Published: June 2024

Objetivo: Describir las características clínicas y el desenlace clínico de los pacientes con cáncer infectados por COVID-19 y evaluar los factores de riesgo asociados a la enfermedad grave. Materiales y métodos: un estudio retrospectivo observacional fue llevado a cabo en Oncosalud-AUNA. Se incluyeron pacientes con diagnóstico de cáncer invasivo con infección confirmada por SARS-CoV-2 mediante ensayo RT-PCR. Se realizaron análisis de regresión logística binaria univariante y multivariante para evaluar la asociación entre las características clínicas y la gravedad. Resultados: Se incluyó un total de 36 pacientes. La mediana de edad fue de 61 años; 36,1% hombres; 58,4% con ≥1 comorbilidad. El cáncer de mama fue la neoplasia más frecuente. El 72% de los pacientes estaban en tratamiento activo contra el cáncer. Todos los pacientes fueron sintomáticos. El 16,7% ingresó en la UCI y el 27,8% de los pacientes fallecieron. La gravedad de la enfermedad fue: leve, 27,8%; moderada, 33,3%; severa, 22,2%; y crítico – SDRA, 16,7%. Los pacientes con enfermedad grave o crítica fueron frecuentemente mayores de 60 años, varones, en ECOG 2-3 y recibían tratamiento con intención paliativa. Conclusiones: Los pacientes oncológicos con COVID-19 fueron frecuentemente adultos mayores con sobrepeso y al menos una comorbilidad en tratamiento activo contra el cáncer y desarrollaron síntomas típicos de COVID-19. Se produjo COVID-19 severo o crítico en más de un tercio de los pacientes. Los pacientes varones y los mayores de 60 años tuvieron mayor riesgo de desarrollar COVID-19 severo o crítico..
Asesoramiento genético, testeo y manejo de pacientes con adenocarcinoma de próstata: recomendaciones de un consenso de expertos del Instituto Nacional de Enfermedades Neoplásicas del Perú
Authors: Neciosup Silvia P. , Gómez Henry L. , Mora Analí P. , Ruiz Rossana , Castañeda Carlos A. , Morante Zaida D. , Valdivieso Natalia I. , Pieschacón José R.
Published: June 2024

El objetivo fue proporcionar herramientas para el perfilamiento genético y manejo de pacientes con adenocarcinoma de próstata. El Consenso lo conformaron oncólogos y genetistas del Instituto Nacional de Enfermedades Neoplásicas y siguió los lineamientos de la Conferencia de consenso de procedimientos operativos estandarizados de la Sociedad Europea de Oncología Médica. La metodología GRADE se utilizó para evaluar la evidencia y hacer recomendaciones. Las guías de práctica clínica fueron calificadas siguiendo el “AGREE II”. A todo paciente con adenocarcinoma de próstata y factores de riesgo se le debería ordenar testeo y asesoramiento genético; el testeo debería incluir BRCA1/2, ATM, CHECK2 PALB2, MLH1, MSH2/6, y PMS2. Genes adicionales pueden solicitarse dependiendo del contexto clínico. En pacientes con cáncer de próstata metastásico resistente a la castración o regional, puede ser considerado el testeo somático. El resultado del testeo puede guiar el tratamiento. En conclusión, existen muchas necesidades insatisfechas en el enfoque y manejo del cáncer de próstata. La evaluación del riesgo genético del cáncer y el asesoramiento genético involucra la identificación y el asesoramiento de individuos con riesgo de cáncer hereditario. Se espera que el asesoramiento y el testeo genético sean incluidos en la práctica clínica diaria.
A case report of pleuropulmonary blastoma: a challenging diagnostic and therapeutic path in pediatrics
Authors: Paredes Gloria , Reyes Omar , José Somocurcio , Del Carpio Alex Rivera
Published: June 2024

3-year-old female with a history of bullectomy at the age of 1-year-old, presented a course of progressive respiratory difficulty, dry cough and fever. Extension studies showed a solid tumor that covered almost the entire right hemithorax, displacing the mediastinum. An upper right lobectomy and lumpectomy were performed but a residual mass remained after surgery. Pleuropulmonary blastoma (PPB) type II-III with DICER 1 germinal mutation was diagnosed. She received the IVADo regimen, reducing the tumor size; however, the remaining residual tumor was inoperable. Consequently, she proceeded with a maintenance phase using the Vinorelbine/Cyclophosphamide regimen, being both regimens part of the non-standardized RMS-2005 protocol. A biopsy of the residual mass reported non evidence of cancer. After a 2-year follow-up, she remains cancer-free. This is a very rare disease lacking a standardized treatment protocol until now. It is associated with a genetic basis in 40% of it cases, linked to DICER1 mutation, and typically manifests within the first five years of life. The multidisciplinary management is key in this disease that can improve improves survival.
A case report of blastic plasmocytoid dendritic cell neoplasm in a pediatric patient: an unusual age of presentation
Authors: Morales-Coloma Melissa
Published: June 2024

La neoplasia blástica de células dendríticas plasmocitoides (BPDCN) es un tipo raro de neoplasia con comportamiento agresivo, que se encuentra con mayor frecuencia en adultos. Sin embargo, es muy poco común en niños y la evidencia documentada es limitada. Se presenta el caso de un paciente de 6 años diagnosticado y atendido en el Instituto Nacional de Salud del Niño de Lima.
Neutrophil-to-lymphocyte Ratio as a PrognosticBiomarker in Peruvian Patients with AcralMelanoma
Authors: Maraví1 Julio , Cámara Anais , Paredes Sally , Beltrán Brady , Castro-Uriol Denisse
Published: June 2024

Objective. Our aim was to evaluate whether NLR, LMR, and PLR serve as prognostic biomarkers in AM, the most frequent subtype of cutaneous melanoma (CM) in Peru. Materials and methods. A retrospective study was conducted, including patients diagnosed with AM between 2010 and 2015. Survival analysis was performed using Kaplan-Meier curves and comparisons were made using the log-rank test. Univariate and multivariate survival models were constructed usingCox regression analysis. A p-value less than 0.05 was considered significant. Results. Among our cohort of 135 patients with CM, 51.1% (69 cases) had AM. The median age was 68 years, with a predominance of females (55%), and 88.4% had the plantar site as the primary site. The 5-year overall survival (OS) rate was 54.3%. In the univariate analysis, Clark level III/IV, anaplasia, lymphocytic invasion, stage III-IV, and NLR were associated with poor prognosis. In multivariateanalysis, NLR >3.5 (HR 3.9, 95% CI 1.5-10.3, p=0.005) and Clark level III-IV (HR 3.5, 95% CI 1.6- 7.8, p=0.002) were associated with poor OS. Conclusion. NLR emerges as an independent prognostic factor for OS among Peruvian patients with AM in a single cancer center institution.
СВЕДЕНИЯ О ДЕПОРТИРОВАННЫХ ИЗ СЕВЕРНОГО КАВКАЗА В УЗБЕКИСТАН И ИЗ УЗБЕКИСТАНА В СЕВЕРНЫЙ КАВКАЗ В 1931-1935 ГОДЫ
Authors: Шахбоз ХОДЖИЕВ
Published: June 2024

Статья посвящается политики депортации проведенная советской властью по отношению народов Узбекистана и Северного Кавказа в 1931-1935 годы. В статье приводятся статистические данные о числе выселенных из Узбекистан в Северный Кавказ, и из Северного Кавказа в Узбекистан.
IMPERATORLIK SHARQSHUNOSLIK JAMIYATI TOSHKENT BO‘LIMI FONDI TAHLILI (O‘ZMA I-361 FONDI ASOSIDA)
Authors: Azizbek NAZAROV
Published: June 2024

Ushbu maqolada Imperatorlik sharqshunoslik jamiyati Toshkent bo‘limining O‘zbekiston Milliy arxivida saqlanuvchi I-361-fondidagi 13 ta yig‘majild arxiv manbashunosligi nuqtai nazaridan tahlil qilingan. Shuningdek, jamiyat ochilishiga oid yozishmalar, rus-tuzem maktablari haqidagi ma’lumotlar, til kurslari faoliyati, aholi yashaydigan xonadonlar va sharoitlar o‘rganilishi, yig‘ilish bayonnomalaridagi masalalar hamda nashr ishlariga oid arxiv hujjatlari tahlili amalga oshirilgan.
FANLARARO INTEGRATSIYA –TA’LIM-TARBIYA JARAYONINING ASOSIY OMILI
Authors: Sherjaxon ABDUFATAYEV
Published: June 2024

Oila, davlat va jamiyat oldida o‘zining fuqorolik burchi, mas’uliyatini chuqur anglaydigan, teran fikirli, ijtimoiy faolligi, yuksak kasbiy mahorati, ijodiy faoliyati hamda ijobiy fazilatlari bilan qurbi yetadigan raqobatbardosh mutaxassislar tayyorlash hozirgi zamon va istiqbol talabidir. Shu nuqtai nazardan kelib chiqgan holda ushbu maqolada umumta’lim maktablarida o’quvchilarning bilim, ko‘nikma va malakalarini rivojlantirish, taminlash yo’llari va natijalari yoritilgan
“REZERV VA ZAXIRADAGI OFITSERLARNI TAYYORLASH JARAYONIDA TALABALARDA OFITSERLIK KASBIGA AXLOQIY-ESTETIK MUNOSABATLARNI SHAKLLANTIRISH MASALALARI”
Authors: Qurbon AMINJONOV
Published: June 2024

Mazkur maqolada ofitserlik kasbiga axloqiy va estetik munosabatlarni shakllantirish masalalari haqida soʻz boradi.
JAHON SIYOSATIDA SUN’IY INTELLEKT
Authors: Feruz BAFOYEV
Published: June 2024

Maqolada o‘zgaruvchan va beqaror zamonaviy jahon siyosati va xalqaro munosabatlarda sun’iy intellekt texnologiyalarining qo‘llanilishi, afzalliklari va nuqsonlari muhokama qilinadi. Sun’iy intellekt texnologiyalari amaliy ko‘magida jahon siyosati va geosiyosat muammolarini hal etishda qo‘llanilishi tahlil qilinib, uning istiqboli, yuzaga keladigan huquqiy va axloqiy muammolar o‘rganilgan.
IJTIMOIY SIYOSAT TUSHUNCHASINING KONTSEPTUAL ASOSLARINING TAHLILI
Authors: Baxrom BAXODIROV
Published: June 2024

Maqolada ijtimoiy siyosatning muhim kontseptual jihatlari, asoslari va yondashuvlari borasida so‘z borgan bo‘lib, unda qator olimlar tomonidan ijtimoiy siyosatga mazmun va mohiyatlari aks etgan ta'riflari mavjud. Undan tashqari maqolada muallif tomonidan ham o‘z shaxsiy qarashlarini ham ilgari surib, ijtimoiy siyosat ta'rifini yanada kengroq ochib berishga uringan.
AKADEMIK LITSEYLARDA MODULLI PEDAGOGIK TEXNOLOGIYA TAMOYILLARI ASOSIDA ELEKTROSTATIKA BO‘LIMINI O‘QITISH METODIKASINI TAKOMILLASHTIRISH
Authors: Erkin VOXIDOV
Published: June 2024

Mazkur maqolada modulli pedagogik texnologiya va uning tamoyillari asosida akademik litseylarda elektrostatika bo‘limini o‘qitish hamda o‘quv jarayonini tashkil etish orqali o‘quvchilar bilimini oshirish, ularning dunyoqarashini shakllantirish, shuningdek, fizika fanini o‘rganishga bo‘lgan motivatsiyasini rivojlantirish to‘g‘risida fikr yuritilgan.
SHARQ VA G‘ARB FALSAFASIDA DINIY-MISTIK KONSEPSIYALAR
Authors: Dilfuza JUMANIYOZOVA
Published: June 2024

G‘arb va Sharq adabiyotlari, tadqiqotlarining tahlilida shaxsni kamolotga eltuvchi dunyoviy va ilohiy omillar tadqiq etilgan, biroq, insoniylik va ilohiylik uyg‘unligiga yetarlicha e’tibor qaratilmaganligi aniqlandi. SHu bois, shaxs ma’naviy kamolotida insoniylik va ilohiylik uyg‘unligining ahamiyatini tadqiq etish muhim ahamiyat kasb etadi. Ushbu maqolada SHarq falsafasida insoniylik va ilohiylik o‘zaro dialektik bog‘liq voqeliklar sifatida kelishi asoslangan.
LOYIHA ISHLARI BAJARISH JARAYONIDA INTEGRATSIYALASHGAN TA’LIM TEXNOLOGIYALARINI QO‘LLASH ORQALI TADQIQOTCHILIK KO‘NIKMALARINI RIVOJLANTIRISH
Authors: Adizjon ISROILOV
Published: June 2024

Ushbu maqolada loyiha ishlarida integratsiyalashgan ta’lim texnologiyalaridan foydalanish va ularning o‘quv jarayonidagi ahamiyati ko‘rsatilgan.
O‘ZBEKISTON HUDUDIDA ICHKI ISHLAR ORGANLARI TASHKIL ETILISHINING NAZARIY-HUQUQIY JIHATLARI
Authors: Аvaz YERMETOV,
Published: June 2024

Maqolada Oʼzbekiston hududida sovet hukumatining oʼrnatilishi, oʼlkada ichki ishlar organlarining tashkil etilishining huquqiy asoslari, ularning sovet tuzumini mustahkamlashdagi oʼrni, Oʼrta Osiyola milliy-hududiy chegaralanish oʼtkazilganidan soʼng Turkiston АSSR, BSSR va XSSRlari faoliyat yuritgan ichki ishlar idoralarining birlashtirilishi, ularga yuklatilgan vazifalar, vakolat va majburiyatlar, shuningdek, tizim boshqaruvidagi oʼzgarishlar va hududiy boʼlinish printsiplari birlamchi manbalar asosida tahlil etilgan.
IMAGING PATTERNS AND CLINICAL CORRELATES OF COVID-19 PNEUMONIA: A CROSS-SECTIONAL STUDY USING HIGH-RESOLUTION COMPUTED TOMOGRAPHY
Authors: Iqbal Sana , Khan Shandana , Rahman Wajeeha , Safdar Anam
Published: June 2024

BACKGROUND: Unknown etiology pneumonia cases were discovered in Wuhan, China in December 2019. These cases are now referred to as coronavirus illness 2019, and the coronavirus is characterized as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). High-resolution computed tomography (HRCT) is an important imaging modality that can help with COVID-19 patient diagnosis and care. 
OBJECTIVE: To assess the imaging patterns of lung involvement of COVID-19 pneumonia on HRCT in suspected COVID-19 patients in Northwest General Hospital and Research Center Peshawar.
METHODOLOGY: It was a cross-sectional study conducted in the Radiology Department, Northwest General Hospital Research Center from 30th March 2020 to  30th June 2021. This study included 80 suspected Covid-19 patients. HRCT of these patients was performed on 16 slices Toshiba Multidetector Computed Tomography (MDCT) scanner in the Radiology Department of Northwest General Hospital and Research Centre.0.5mm reconstructed images in lung window and 3mm images in the mediastinal window were viewed on the workstation in axial, coronal and sagittal planes. The data was processed using SPSS version 16.0
RESULTS: We included 80 suspected COVID-19 pneumonia patients who presented to our department with or without symptoms of chest infection or fever. They were considered for our study irrespective of age group and gender. We found that a great number of patients (41.2%) were symptomless, despite lung parenchymal involvement. Eight patterns of distribution in the lung were found on HRCT, amongst which involvement of both lower lobes was most prevalent (32.5%). Radiological patterns of the disease process included GGH (82.5%), consolidation (60%), both GGH and consolidation (52%), crazy paving pattern (65%), pulmonary nodules (37.5%), interlobular septal thickening (71.2%), pleural bands (32.5%), bronchial wall thickening (20%) and pleural effusion (12.5%)
CONCLUSION: HRCT is an effective diagnostic modality in the early identification of COVID-19 pneumonia. The majority of patients had bibasal involvement followed by peripheral subpleural distribution. Amongst the findings, GGH was found to be the most frequent finding on HRCT
KEYWORDS: COVID-19 pneumonia, High-resolution computed tomography (HRCT), Multidetector computed tomography (MDCT)
HOW TO CITE THIS ARTICLE: , Safdar A. HRCT a helpful solution in suspected COVID-19 pneumonia cases. Northwest J Med Sci 2024;3(1):25-29
SONOGRAPHIC ASSOCIATION OF RENAL PARENCHYMAL DISEASE GRADING WITH AGE AND KIDNEY DIMENSIONS: A CROSS SECTIONAL STUDY
Authors: Afridi Muhammad Arif , Khan Imran , Khan Lumaa Mirta , Ahmad Waqas , Khalid Malik Mairaj
Published: June 2024

BACKGROUND: Chronic Kidney Disease (CKD) presents a notable worldwide health concern. This study focuses on the sonographic assessment of renal parenchymal disorders using gray-scale ultrasonography, aiming to categorize illnesses based on echogenicity, renal size, and cortical thickness.
OBJECTIVE: This study focuses on the sonographic assessment of renal parenchymal disorders using gray-scale ultrasonography, aiming to categorize illnesses based on echogenicity, renal size, and cortical thickness to enhance clarity.
METHODOLOGY: During the period from July to December 2023, a cross-sectional study took place at the Radiology Department of the Institute of Kidney Diseases in Peshawar. Data from 293 patients were analyzed, applying descriptive statistics, cross-tabulations, and correlational analyses to explore relationships between age, kidney dimensions, and CKD grading.
RESULTS: The study revealed a mean age of 46.56 years, with the highest CKD frequency in the age group of 41 to 60 years. Echogenicity grading demonstrated 12.97% mild, 25.26% moderate, 60.07% moderately severe, and 1.71% severe CKD cases. Significant correlations were observed between age and kidney dimensions, emphasizing the need for proactive screening.
CONCLUSION: Ultrasound proved effective in detecting renal abnormalities, highlighting increased echogenicity, reduced cortical parenchymal thickness, and diminished renal size, especially prevalent in elderly patients. The study underscores the urgency for enhanced healthcare awareness, particularly in resource-limited rural areas, advocating for proactive screening and early intervention strategies to address renal health challenges.
KEYWORDS: CKD, Echogenicity, Grading, Gray Scale, Renal Parenchymal Disease, Ultrasound
Icebreakers
Authors: Linder Eva-Liisa
Published: June 2024

The Singing Revolution which led to the restoration of Estonian independence in 1991, was accompanied by a cultural ‘sexual revolution’. After the cessation of theatre censorship in 1988, cultural influences in repertoire shifted from East to West, allowing for the exploration of once-taboo subjects like gender and sexuality. This fostered modern queer theatre, that embraces LGBTQ+ themes, characters, and aesthetics. Estonian queer theatre quickly evolved from portraying dandy figures and gay heroes to transgender and drag characters. It embraced various styles from psychological realism to documentary, devised, and physical theatre.This paper explores queer elements within Estonian theatre, set against the backdrop of Western queer theatre history. It focuses on the last decades, examining how queer theatre functioned as a litmus test of democracy and challenged post-Soviet norms from a cultural research perspective. Grounded in basic research of stage messages and media reception, it reflects societal attitudes and the trauma of social change. Throughout the history of Estonian theatre, queer themes have appeared in over a hundred productions, resonating in more than five hundred reviews and attracting an estimated one million theatre visits in a country of 1.3 million. This article marks the first mapping of Estonian queer theatre.
Performative Protest Actions in the Baltic States Against Sexual Violence in Russia’s War in Ukraine
Authors: Oruaas Riina
Published: June 2024

In the article I consider women’s performative protest actions against sexual violence in Russia’s war against Ukraine and their media images. After the withdrawal of the Russian army from Kyiv, a massive amount of war crimes against civilians in its suburbs were revealed. The article gives an overview of the protest actions and their media afterlife in the Baltic states in spring 2022, discusses the representational strategies and media photos based on Rancière’s essay “The Intolerable Image”, considers the issue in the contexts of the public sphere, and the feminist research on women’s life stories and representational strategies that try to depict women’s experiences in war. The events are historically contextualized in a discussion on women and war based on the research of WWII memoirs and autobiographies (Kurvet-Käosaar 2000, Alexievich 2017, Paju 2005). The protest actions and their media images created a transgressive zone of disturbance where several modes of public sphere and social practices, including protest, art, media, mourning, etc. intertwine.
Performative Representation of “Others” in the Opera Genre
Authors: Paltanavičiūtė Justina
Published: June 2024

Western opera has a longstanding tradition (from Giovanni Battista Pergolesi to Astor Piazzolla) of the representation of the lower strata of society, which usually involves appropriation of the performativity of social groups other than the composer’s own. Such procedure is made for transgressive aims in order to affect the status quo of public discourse and improve social reality. The aim of the research presented in this article is to empirically establish whether the performative representation of a socially vulnerable group in opera affects and empowers individuals belonging to the group. A case in point is a contemporary opera Have A Good Day! (2011) by Lithuanian authors Lina Lapelytė, Vaiva Grainytė, and Rugilė Barzdžiukaitė, which represents the professional activities of supermarket cashiers. The article presents the results of empirical research on the reception of the opera. The research was undertaken by showing the opera to participants who actually work as cashiers. Consequently, the participants were interviewed, and a qualitative content analysis of the gathered data was conducted. The argument of the article is based on theoretical insights on empowerment by Grant Kester, who suggests that artists, in an attempt to empower, might still be exercising unequal power relations. Thus, the real transgression might never take place. The argument of this article is that Have a Good Day! attempts to, but fails to empower its subjects.
Polishing Reykjavík
Authors: Skjoldager-Nielsen Daria
Published: June 2024

After noticing the great interest of the Polish migrants in Polish cultural events in Reykjavík, Ólafur Ásgeirsson saw a niche for his artistic explorations. He created PólíS, a theatre group comprised of Poles and Icelanders, professional and amateur actors. Polish actors to create performances aimed at the Polish minority. PólíS’s second production, Tu jest za drogo (It’s too expensive here), was staged at the Reykjavík City Theatre, a prestigious location for Reykjavík’s cultural life in 2022. This move transgressed social and political boundaries, perhaps even challenging the city’s cultural life and beliefs about the immigrant’s place in the fabric of the city.In my article, firstly, I position Tu jest za drogo among other strategies for staging performances in foreign languages. Secondly, I place it in a transmigrant context (Glick Schiller 1995), which studies embeddedness in two or more cultures, to explain to whom and why the PólíS’ strategy might appeal. Thirdly, I refer to the concept of third space in theatre (Woodson 2015) to explain the power relations in the creation and reception processes.My material comes from semi-structured interviews with the PólíS’ members and a City Theatre representative, as well as qualitative analysis of the social media texts and analysis of the PólíS’ play Tu jest za drogo.
Theatre and Transgression
Authors: Korsberg Hanna
Published: June 2024

I will discuss transgression and debated boundaries in performing arts in this article. I will be looking at a production of Jean-Paul Sartre’s Dirty Hands at the Finnish National Theatre in 1948 and discussing the political norms of transgression in theatre at an unstable moment in Finnish history. The production premiered on 8 October 1948 and was performed for two months only. On 5 December 1948, Finland received a note from the Soviet Union, the reason was hostile action towards the Soviet Union. After the note, Dirty Hands was performed no more. In Chris Jenks’s definition, transgression is “to go beyond the bounds or limits set by a commandment, the law or the convention.” It is a “conduct which breaks rules or exceeds boundaries.”(Jenks 2003, 2.)Transgression can be dangerous and challenge dominant hierarchies and authorities. What kind of a transgression took place in Dirty Hands? What strategies did the theatre and the artists participating in the production use to negotiate the transgression? Reading this performance through transgression, I argue that the theatre had a vital function in creating an understanding of the nation’s role in Finland after WWII.
The originality of Chinoiserie-style garden architecture in England in the XVIII century
Authors: Yu Zhengyang
Published: June 2024

The article "The originality of Chinoiserie-style garden architecture in England in the XVIII century" explores the development and specifics of Chinoiserie style in the landscape architecture of England. Chinoiserie style refers to the use of Chinese motifs and stylistic techniques in European architecture. The aim of the work is to identify the specifics of the arrangement of English gardens and parks in the Chinoiserie style. The subject of the study is the stylistic features of the embodiment of Chinoiserie gardens and parks. The object of the study is parks and garden architecture in the Chinoiserie style in England. The study covers the 18th century, revealing the contribution of individual architects and the influence of Chinese art on the development of garden architecture. The presented analysis demonstrates how architectural styles of Western and Eastern culture can mix. English gardens and parks are evidence of the influence of Chinese aesthetics on landscape gardening, which later spread to continental Europe. In the course of the research, the following methods were mainly used: historical, historical-genetic, historical-comparative. In the study of specific objects of landscape architecture, methods of art criticism analysis were applied — formal, stylistic and comparative methods. The article examines specific English monuments of landscape architecture of the XVIII century taken as examples the Chinoiserie style. The novelty of the study lies in the fact that the features of the Chinoiserie style in the landscape architecture of England were highlighted and a comparison of English architectural objects in the Chinoiserie style with Chinese analogues was carried out. The conducted research revealed the English specifics in the approach to interpreting Chinese designs of gardens and parks and architectural projects in the XVIII century. English gardeners and architects were inspired by Chinese aesthetics and used oriental elements for decoration, but did not follow all architectural canons and traditions. This gave rise to a new Chinoiserie style, a combination of Chinese and European landscape art that spread throughout Europe.
Quality by design approach for the formulation of bilayer tablets of domperidone and itopride in gastro esophageal reflux disease
Authors: Prajapati Roshani , Kumar Bhavna , Sahoo Jagannath , Shakya Shailendra , Lal Diwya Kumar
Published: June 2024

In the current work, a bilayer tablet of itopride gastroretentive and domperidone immediate release formulation was developed showing the synergistic effect of gastric motility in gastroesophageal reflux disease, through antidopaminergic and antiacetylcholine stearic activities. A bilayer tablet of domperidone and itopride was optimized using quality by design and its product performance was analyzed. Itopride was designed to be gastroretentive and remains in the stomach for a longer period, providing sustained release. The domperidone layer was optimized by an empirical hit and trial method, while the itopride layer was optimized using the Box Behnken experimental design. Three independent variables were considered as hydroxypropyl methyl cellulose K 100 M, xanthum gum, and Carbomer 974 with dependent variables like floating lag time, swellable index, and percentage drug release at 24 hours. Quality target product profile and critical quality attributes were studied which helps in an effective way to develop bilayer tablets. The excipients were chosen based on the time taken by medicaments to be released and the quantity was optimized according to Handbook of Pharmaceutical Excipient. From the optimization processes, DF5 and IH2 were selected as optimized composition for the formulation of domperidone and itopride layer of bilayer tablet respectively. The bilayer tablets were formulated in 16 × 8.26 mm oblong plain biconcave die and punch. The in-vitro drug release of domperidone was 99.39% in 30 minutes and itopride was 27.50%, 53.45%, and 93.65% at 4, 16, and 24 hours respectively.
Optimization of microwave-assisted extraction of total flavonoid content from red betel leaf (Piper crocatum Ruiz and Pav) and its correlation with antioxidant and antibacterial activities using response surface methodology
Authors: Astyka Ririn , Zaitun Hasibuan Poppy Anjelisa , Sumaiyah Sumaiyah , Juwita Nur Aira , Lubis Muhammad Fauzan
Published: June 2024

The optimization of microwave-assisted extraction (MAE) was conducted using response surface methods to improve the extraction of flavonoids from Piper crocatum Ruiz and Pav leaf. The optimization process included a Box–Behnken experimental design (BBD), which involved three variables at three levels. The present study aimed to evaluate the impact of varying ethanol concentrations (50%, 75%, and 100%), microwave power levels (180, 300, and 450 W), and extraction durations (3, 8.5, and 14 minutes) on the respective responses. The experimental data was subjected to fitting using a second-order polynomial model. Subsequently, an analysis of variance (ANOVA) and multiple regression analysis were employed to assess the adequacy of the model and determine the ideal settings. Taking into account the highest concentration of extracted total flavonoids, as well as the antioxidant and antibacterial properties. The experimental results indicate that the optimum conditions for all the reactions under investigation were an ethanol concentration of 78.48%, a microwave power of 327.96 W, and an extraction duration of 8.60 minutes. Under the ideal conditions, the anticipated outcomes of the sample indicate a total flavonoid content (TFC) of 229.647 mg QE/g dry weight (DW), a 1,1-diphenyl-2-picryhydrazyl (DPPH) scavenging activity of 73.915%, and an inhibition zone measuring 18.621 mm. The implementation of a concurrent MAE methodology for the isolation of total flavonoids, as well as the evaluation of antioxidant and antibacterial properties from P. crocatum, signifies the recognition of the extract as a significant reservoir of bioactive substances.
Chromatographical fingerprint analysis, in silico investigation, and identification of hepatoprotective active compounds from Capparis decidua Edgwe (Forssk.)
Authors: Osman Wadah , Mirghani Mohamed , Mohamed Mona , Sherif Asmaa E. , Ashour Ahmed , Sweilam Sherouk Hussein , Subki Hassan
Published: June 2024

Liver disorders are globally distributed with a high burden of disease costs. The methanolic extract of Capparis decidua stem part and its dichloromethane (DCM) and ethylacetate fractions showed significant hepatoprotective activity, so this study aimed to develop gas chromatography/mass spectrometry (GC/MS), high-performance thin layer chromatography (HPTLC) fingerprint profile and in silico docking of identified compounds from both fractions responsible for hepatoprotective activity. Hexadecanoic acid, 9-octadecenoic acid, 9,12,15-octadecatrienoic acid, and dihydrolinalool are known hepatoprotective and antioxidant agents that were identified from both fractions by GC/MS, they have various degrees of hepatoprotective and antioxidant properties, this is the first time to identify hexadecanoic acid in C. decidua stem. Both fractions were chromatogramed with known hepatoprotective standard compounds, they were rutin, quercetin, kaempferol, ferulic acid, oleanolic acid, and β-sitosterol; β-sitosterol and oleanolic were isolated and identified in the DCM fraction by HPTLC, but nothing of these standard compounds were identified in the ethylacetate fraction. According to International Council for Harmonization guidelines, the HPTLC fingerprint profile method was validated to confirm our isolation and identification process of β-sitosterol and oleanolic acid in the DCM fraction, also their contents were quantified and they were 9.21 and 7.73 μg/mg, respectively, in the total dry fraction weight, this was the first time to isolate and identify oleanolic acid from C. decidua stem part. In silico docking was carried and was found that hexadecanoic acid showed significant predicted binding properties on Nrf2, p38 mitogen-activated protein kinase, and IL-1 receptor proteins. 9-octadecenoic acid (elaidic acid) showed significant predicted interactions with IL-1 receptor, Nrf2, and peroxisome proliferator-activated receptor-α (PPAR-α) proteins. Oleanolic acid showed significant predicted bindings with p65, JNK, and NF-kb. β-sitosterol showed significant predicted interaction with IL-6α protein, while 9,12,15-octadecatrienoic acid revealed significant binding with PPAR-α protein. Therefore, we recommend considering our active compounds in the field of drug development (structure-activity relationship) and the possibility of the presence of synergism if they are combined and administered together. Moreover, we recommend liquid chromatography-mass spectrometry and nuclear magnetic resonance on both fractions to search for the possibility of the presence of other hepatoprotective compounds.
Triplet analysis: Quantifying ivacaftor, tezacaftor, and elexacaftor in plasma with mass spectrometry
Authors: Inturi Ravikanth , Inturi Srikanth , Medepalli David Raju , Mandava Venkata Basaveswara Rao
Published: June 2024

A novel and highly precise method were developed and rigorously validated for quantifying ivacaftor (IVA), tezacaftor (TEZ), and elexacaftor (ELX) in human plasma. This method leverages multiple reaction-monitoring mass spectrometry for its analytical approach. During the validation process, the method demonstrated its robustness across a wide concentration range: 0.151 to 40.382 ng/ml for ELX, 0.101 to 30.010 ng/ml for IVA, and 20.187 to 6,026.032 ng/ml for TEZ in human plasma. Importantly, this method exhibited exceptional accuracy and reproducibility even at lower concentrations. The mobile phase employed in this analysis consisted of methanol and 0.1% formic acid at a ratio of 85:15 (v/v), with a flow rate set at 1.0 ml/minute. Additionally, linear correlations were established within the human plasma for ELX (R2=0.9983), IVA (R2=0.9992), and TEZ (R2=0.9989). In conclusion, this newly developed method is dependable and precise for the accurate quantification of IVA, TEZ, and ELX, especially when dealing with lower concentrations in human plasma analysis.
State action and the expansion of finance during the Spanish housing crisis
Authors: Sabaté Muriel Irene
Published: June 2024

This paper addresses the entanglements, complicities and collisions between financialization processes and state action during the current housing crisis in Spain, with a focus on Catalonia and the Barcelona area in the last decade. Departing from the assumption that housing financialization has been a major driver of the crisis, state interventions, including housing policies and legal regulations imposed on financial and real estate markets and on landlord-tenant relations, will be interpreted as modulators that may either alleviate or amplify the impacts of financial dynamics on people’s access to adequate housing. Drawing on the cases of several legal reforms, we will illustrate variegated attitudes towards financial extraction adopted by different state agencies. It will be thus shown how, in the rare cases where the state has tried to alleviate the social harms derived from financial extraction, reforms have been superficial, have arrived late, and have failed to reverse the structural drivers of the crisis. We will thus try to shed some light into the nature of state action in the face of housing financialization, contending that states should not be understood as outsides with respect to finance, as, to the contrary, they are part of finance’s very conditions of possibility.
La finanziarizzazione come riproduzione sociale
Authors: Carabini Camilla
Published: June 2024

This article aims to introduce the reader to the anthropology of finance in its contemporary dimension of financialization. Through the lens of the feminist manifesto “GENS” (Bear et al. 2015), the author proposes a reading of ethnographies that highlights the interconnectedness of individuals’ agency, projects of social reproduction, power hierarchies, and processes of money accumulation. Moreover, the article how the financial industry reproduces race, gender, and class inequalities both within societies and on a global scale, becoming increasingly pervasive in development discourse. The article is divided into three parts based on the relationship between individuals and the financial valuation process they engage in. It analyzes the experts who work within financial institutions; the social reproduction processes of the working classes increasingly reliant on credit and debt mechanisms introduced by financial capitalism; and the people excluded from global financial dynamics, whose financial inclusion is considered the most effective tool to escape poverty by governments and international organizations.
Residui sacrali nei musei
Authors: Gamberi Valentina
Published: June 2024

This article reflects on the existing dynamics between the sacredness derived from the museumification of religious items and the sacredness of those artefacts employed in rituals that survive in museum spaces as a trace or sacred residue (Beekers 2016). Which sacrality predominates, and how do they influence each other? Through an ethnography conducted in several Taiwanese museums, the article probes into a stratification of sacralities: the encounter between Buddhist and Chinese religious practitioners with museum artefacts’ sacred residue reflects complex and unpredictable dynamics. The ethnography presented in this article is defined as membrane ethnography since the relationship between humans and matter is like a membrane that unites and simultaneously separates, filters and subjectifies. This article extends the meaning of sacred residue by examining the reproducibility of religious artefacts through technological or experiential means. The latter, rather than determining the artefacts’ inauthenticity, makes the sacred residue more explicit. Furthermore, the ethnography of the membrane shows how non-European contexts are permeated by porosity and interdependency between the secular and the sacred of religious heritage, thus preventing a dichotomisation between museums and ritual contexts for analysing the implied dynamics between them instead.