bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of personalized pharmacokinetics-guided prophylaxis using standard half-life factor VIII in patients with hemophilia A
Authors: Duereh Amara
Published: February 2025

Abstract
Introduction: Patients with Hemophilia A (HA) are at risk of severe bleeding and joint damage, which can lead to disability. Nonpharmacokinetic (PK)-guided prophylaxis treatment may not be suitable for all patients, as it does not involve personalized prophylaxis tailored to their activity levels. Objective: This study aimed to evaluate the clinical impact of PK-guided prophylaxis using standard half-life factor VIII (SHL FVIII) based on  activity risk levels in patients with severe phenotype HA. Material and method: This retrospective and prospective cohort study compared data from the same group of patients receiving prophylactic treatment at Naradhiwasrajanagarindra Hospital between September 2023 and August 2024. Data from 6 months before and 6 months after the implementation of personalized PK-guided prophylaxis, combined with activity risk level design and digital diary application monitoring, were compared. Collected data included the annualized bleeding rate (ABR), annualized joint bleeding rate (AJBR), Hemophilia Joint Health Score (HJHS), Functional Independence Score in Hemophilia (FISH) and weekly consumption of SHL FVIII. Result: The study included 12 participants (mean age ± standard deviation [SD]: 16 ± 6.95 years). The results showed statistically significant reductions in ABR, AJBR, and HJHS (P = 0.005, 0.007, and 0.002, respectively). The median (interquartile range [IQR])FISH score increased from 26.50 (24 – 28.5) to 28 (26 – 29.75) (P = 0.002), while weekly SHL FVIII consumption did not significantly increase. Conclusion: Personalized treatment adjustments using PK data SHL FVIII and digital tools effectively improved treatment outcomes and supported patient activities.
An Investigation into the Gender-Based Ability of Secondary School Students to Learn English as a Foreign Language Concerning Biases and Gender in Language Learning
Authors: Isbahi Muhammad Baiqun
Published: February 2025

The language learning process promotes inclusivity by accounting for differences in intelligence regarding English as a foreign language between male and female pupils, which has a direct impact on their proficiency in language acquisition. The present study examines the gender-based disparity in language acquisition, concentrating on the English language competence of secondary school pupils. By examining the correlation between gender identity and English learning outcomes, this study seeks to fill a knowledge deficit regarding the inclusiveness of the language learning process. The researchers apply feminist stylistics and systemic functional linguistics to the analysis of written text products of high school pupils, which were gathered as part of an extensive data collection effort. Utilizing this analysis, they investigate how texts are constructed and scrutinize the impact of gender on the selection of linguistic structures. The results obtained from this research enhance our comprehension of disparities in language acquisition based on gender and provide valuable perspectives for the enhancement of language education methodologies that promote fairness and inclusivity for every student.
An Empirical Study on the Cognitive Processes and Translation Strategies for Foreign Language Majors Based on the Think-Aloud Protocols
Authors: Xu Xujiayi
Published: February 2025

Think-Aloud Protocols (TAPs) are empirical research methods suitable for small-sample longitudinal investigations which have significant application in foreign language translation research. Taking the 2nd and 4th-year English majors of Yancheng Institute of Technology as the object of investigation, this study explores the cognitive processes and translation strategies of foreign language majors. It is concluded that investigating the cognitive processes and translation strategies of foreign language majors through the Think-Aloud Protocols has a very positive significance for improving their translation proficiency.
Tratamentos emergentes para dermatite atópica: Uma análise dos avanços terapêuticos e das novas opções de tratamento
Authors: Silva Eliana Marques Gomes da , Machado Nailma Taynara da Costa , Lopes Vitor Velloso , Alfaia Amanda Osman , Arce Ayslan Barros , Rodrigues Brenna Suzy Lima , Ferreira Fernanda Lima , Menezes Luiza Augusta Calheiros , Macedo Amanda De Souza Chaves , Goes Ana Beatriz Nobre , Assunção Leila jane Brito , Alves Giglaherbete Miranda , Tapajós Bruna Goes , Abreu Abraão Gomes
Published: February 2025

A dermatite atópica (DA) é uma doença inflamatória crônica da pele que afeta milhões de pessoas em todo o mundo, causando desconforto significativo e impactando a qualidade de vida. Embora tratamentos tradicionais, como corticosteroides tópicos, sejam amplamente utilizados, novas abordagens terapêuticas emergem com o avanço da pesquisa médica. Este estudo explora os mais recentes desenvolvimentos no tratamento da dermatite atópica, incluindo terapias biológicas e medicamentos imunomoduladores. O objetivo desse estudo é analisar os tratamentos emergentes para dermatite atópica, com ênfase nos avanços terapêuticos recentes e suas novas opções. Para a coleta de dados, foram consultados diversos repositórios, incluindo a Scientific Electronic Library Online (SCIELO), PubMed e a base de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Os tratamentos emergentes, como inibidores de Janus quinase (JAK) e anticorpos monoclonais, demonstraram resultados promissores no controle dos sintomas da dermatite atópica. Estes tratamentos oferecem alternativas eficazes para pacientes com DA moderada a grave, especialmente aqueles que não respondem bem aos tratamentos tópicos convencionais. Os tratamentos emergentes para dermatite atópica representam uma evolução significativa na gestão da doença, proporcionando novas opções para os pacientes que não respondem bem aos tratamentos convencionais.
Carcinoma Hepatocelular: Avanços recentes no diagnóstico, tratamento e perspectivas terapêuticas
Authors: Gaião Lara Bortolanza , Câmara Rafaela de Jesus , Ramos Amanda Alves , Castro Iran Barros de
Published: February 2025

O carcinoma hepatocelular (CHC) é o tipo mais comum de câncer primário do fígado, representando a principal causa de mortalidade por câncer no mundo. Está fortemente associado a condições hepáticas crônicas, como cirrose e infecções crônicas pelos vírus da hepatite B e C. O CHC é frequentemente diagnosticado em estágios avançados devido à falta de sintomas precoces, o que torna seu tratamento mais desafiador. Embora as opções terapêuticas, como ressecção cirúrgica, transplante hepático e terapias sistêmicas, tenham evoluído, o prognóstico ainda é reservado, sendo necessário o desenvolvimento de novas abordagens diagnósticas e terapêuticas para melhorar a sobrevida dos pacientes. Essa revisão de literatura foi realizada por meio de publicações científicas encontradas nos seguintes bancos de dados: Biblioteca Virtual de Saúde (BVS), Public Medline (PubMed), Portal de Periódicos CAPES e Scientific Electronic Library Online (SciELO), sem restrição de período. Foram também consultados os sites oficiais do Ministério da Saúde e a literatura cinzenta. O carcinoma hepatocelular (CHC) permanece um desafio significativo, com altas taxas de mortalidade e diagnóstico geralmente tardio. Avanços recentes no diagnóstico, como novas técnicas de imagem e biomarcadores, melhoraram a detecção precoce. No tratamento, terapias como imunoterapia, terapias alvo e medicina de precisão têm mostrado promissores resultados, especialmente em estágios avançados. Embora o controle da doença tenha melhorado, a mortalidade continua alta devido à associação com doenças hepáticas crônicas. A implementação de rastreamento em populações de risco e o contínuo desenvolvimento de terapias inovadoras são essenciais para transformar o tratamento e prognóstico do CHC nos próximos anos.
Aplicación del enfoque Moodle para potenciar el aprendizaje de lengua y literatura en niños de educación básica
Authors: De la Rosa Tomala Liliam Mariana , Jaramillo Infante Mónica Karina , Tomala Chavarría Jose Hilario , Parrales Domínguez Ambar Ivonne , Bernabé Rodríguez Rita Maribeth
Published: February 2025

La incorporación de plataformas como Moodle ofrece nuevas posibilidades para el aprendizaje por esta razón el presente estudio explora el impacto del modelo educativo Moodle en la enseñanza de Lengua y Literatura, con el objetivo evaluar el impacto del uso de la plataforma Moodle en el desarrollo de habilidades de comprensión lectora y producción escrita en estudiantes de educación básica en la asignatura de Lengua y Literatura. La investigación aplicó un diseño cuasiexperimental con un grupo experimental y un grupo de control siendo un enfoque mixto en una muestra de estudiantes de séptimo año de Educación Básica. Los métodos incluyeron pre-test y post-test para medir el rendimiento académico, encuestas de percepción sobre la motivación y el compromiso. Los resultados indican que los estudiantes del GE, quienes utilizaron Moodle, mostraron una mejora significativa en sus calificaciones promedio en el post-test (media = 8.48) en comparación con el grupo control (media = 7.69). Además, el análisis cualitativo de las encuestas reveló que el 92% de los estudiantes experimentales considera que Moodle facilita la autonomía y motiva la participación en las clases. Estos hallazgos resaltan la efectividad del modelo Moodle en fomentar un aprendizaje activo, la motivación y el desarrollo de competencias en Lengua y Literatura. La investigación concluye que Moodle es una herramienta educativa viable para mejorar el proceso de enseñanza en contextos digitales.
MỘT SỐ DẪN LIỆU VỀ ĐẶC SINH HỌC VÀ SỰ BIẾN ĐỘNG QUẦN THỂ LOÀI SÂU XANH ĂN LÁ BỒ ĐỀ (Syntypistis sp.) TẠI PHÚ THỌ
Authors: Bùi Quang Tiếp , Trần Viết Thắng , Trần Thanh Trăng , Trần Anh Tuấn , Vũ Văn Lợi , Phùng Xuân Dũng
Published: February 2025

Kết quả nghiên cứu từ tháng 3/2023 đến tháng 7/2024 tại Trung tâm nghiên cứu Bảo vệ rừng ở điều kiện nhà lưới (nhiệt độ trung bình: ttb= 27,8oC, độ ẩm trung bình: RHtb=76,4%), phòng thí nghiệm (nhiệt độ trung bình: ttb = 27oC, độ ẩm trung bình RHtb = 75%) đã xác định được một số dẫn liệu về đặc điểm hình thái, sinh học và diễn biến mật độ quần thể loài Sâu xanh ăn lá bồ đề như sau: Sâu xanh ăn lá bồ đề có 4 giai đoạn phát triển (Trưởng thành, trứng, sâu non và nhộng). Thời gian hoàn thành vòng đời của Sâu xanh ăn lá bồ đề trung bình 34,2 ± 4,7 ngày. Trong đó trưởng thành cái tiền đẻ trứng là 2,8 ± 0,3 ngày, trứng là 4,6 ± 0,6 ngày, sâu non là 16,8 ± 2,1 ngày, tiền nhộng là 2,1 ± 0,4 ngày và nhộng là 7,9 ± 1,3 ngày. Sâu xanh ăn lá bồ đề là loài Syntypistis sp.. Điều tra đánh giá sự biến động mật độ quần thể loài Sâu xanh ăn lá bồ đề ngoài hiện trường ở lâm phần rừng bồ đề (≤ 3 năm tuổi và > 3 năm tuổi) ở huyện Tân Sơn (xã Thu Cúc và Đồng Sơn) và huyện Thanh Sơn (xã Thượng Cửu) từ tháng 3/2023 đến tháng 2/2024 cho thấy từ tháng 5 đến tháng 7 là thời điểm giai đoạn sâu non Sâu xanh ăn lá bồ đề có xu hướng phát triển mạnh và có mật độ quần thể cao nhất vào tháng 8.
NGHIÊN CỨU ĐA DẠNG HỆ THỰC VẬT RỪNG VÀ ĐỀ XUẤT CÁC GIẢI PHÁP BẢO TỒN ĐA DẠNG SINH HỌC TẠI KHU BẢO TỒN THIÊN NHIÊN MƯỜNG LA, TỈNH SƠN LA
Authors: Đinh Công Trình , Hoàng Diệp Linh , Hà Văn Tiệp , Đinh Văn Thái
Published: February 2025

Kết quả điều tra bổ sung tính đa dạng thực vật tại khu bảo tồn thiên nhiên Mường La, tỉnh Sơn La đã ghi nhận được 1.015 loài thực vật, thuộc 5 ngành thực vật (ngành Thông đất, ngành Dương xỉ, ngành Cỏ thấp bút, ngành Thông và ngành Hạt kín). Ghi nhận 10 họ có số lượng loài lớn là Thầu dầu, Cúc, Hòa thảo, Đậu, Vang, Dẻ, Na, Ráng mộc sỉ, Cà phê, Lan. Các loài thực vật phân bố tại 8 dạng sinh cảnh gồm các hệ sinh cảnh rừng tự nhiên, rừng trồng, trảng cây bụi, trảng tre nứa, trảng cỏ, nông nghiệp, khu dân cư và thủy vực. Các loài thực vật ở 5 dạng sống cơ bản gồm nhóm cây chồi trên, nhóm cây chồi sát đất, chồi nửa ẩn, chồi ẩn, chồi một năm. Kết quả nghiên cứu cũng ghi nhận được 21 loài theo Danh lục đỏ IUCN (2020), 31 loài trong sách Đỏ Việt Nam, 56 loài theo Nghị định số 84/NĐ-CP (2021). Nghiên cứu cũng đã đánh giá các mối đe dọa chủ yếu tới đa dạng sinh học khu vực nghiên cứu, từ đó đề xuất được 4 nhóm giải pháp chủ yếu để bảo tồn đa dạng sinh học cho khu bảo tồn thiên nhiên Mường La.
Implementation of E-Learning Based Learning at Islamic University of Nusantara (UNINUS)
Authors: Aisyah Ia Siti , Komarudin Komarudin
Published: February 2025

Penerapan e-learning di lembaga pendidikan tinggi Islam menghadapi tantangan khusus dalam pengimplementasian e-Learning dalam pembelajaran, sehingga perlu adanya pengkajian tentang implementasi E-learning di Salah satu pengguruan tinggi Islam. Penelitian ini mengkaji implementasi e-learning di Universitas Islam Nusantara (UNINUS) Bandung, dengan fokus pada efektivitas, tantangan, dan integrasinya dengan nilai-nilai pendidikan Islam. Menggunakan pendekatan deskriptif kualitatif, data dikumpulkan melalui wawancara, observasi kelas, dan analisis dokumen. Hasil penelitian menunjukkan bahwa UNINUS telah berhasil menerapkan model pembelajaran berbasis E-learning dengan beberapatahan dan ada dampaknya tehadap kualitas mahasiswa dan administratif. Penelitian mengidentifikasi tiga faktor kunci keberhasilan: pengembangan infrastruktur yang komprehensif, pelatihan kompetensi digital yang sistematis bagi pendidik, dan keberhasilan integrasi nilai-nilai Islam ke dalam lingkungan pembelajaran digital. Namun, tantangan masih ada dalam keandalan infrastruktur teknis dan beragamnya tingkat literasi digital di antara pemangku kepentingan. Penelitian ini berkontribusi pada pengembangan pengetahuan tentang transformasi digital di pendidikan tinggi Islam dan memberikan wawasan praktis bagi institusi Islam lainnya yang menerapkan sistem e-learning. Studi ini menunjukkan bahwa keberhasilan implementasi e-learning di institusi Islam memerlukan pendekatan seimbang yang mempertahankan nilai-nilai tradisional sambil mengadopsi kemajuan teknologi.
Kata Kunci: implementasi e-learning, pendidikan tinggi Islam, transformasi digital, UNINUS.
Efectividad de trabeculoplastia láser diodo micropulso en pacientes sin tratamiento previo: estudio retrospectivo con seguimiento de 12 meses
Authors: Arrigone Maitén C. , Castellanos Juan Cruz González , Osaba Matías , Fornero Luis Pablo , Reviglio Víctor E.
Published: February 2025

Introducción: La trabeculoplastia láser diodo micropulso (MDLT, por sus siglas en inglés) se utiliza en el tratamiento de glaucoma de ángulo abierto desde 2005. Hasta la actualidad, no se ha evaluado la efectividad de la MDLT sobre 360 grados del trabeculado en pacientes con glaucoma primario de ángulo abierto sin tratamiento previo.
Población y método: Se realizó un estudio observacional retrospectivo en pacientes atendidos en el servicio de Oftalmología del Instituto de la Visión Cerro de Córdoba. Se evaluaron veintinueve ojos con glaucoma primario libres de tratamiento desde julio de 2018 a julio de 2019. Se midió la presión intraocular antes de realizar el tratamiento de MDLT, a los siete días, un mes, tres, seis y doce meses postratamiento. A su vez, se evaluó la necesidad de incorporar medicación.
Resultados: La presión intraocular a los 12 meses tuvo una reducción del 26,83%. Cinco ojos tuvieron que iniciar tratamiento tópico hipotensor debido a que sus valores de PIO no estaban dentro de los deseados.
Conclusiones: El tratamiento con MDLT es un tratamiento útil en pacientes libres de tratamiento en glaucoma primario de ángulo abierto.
Müsteşrik Julius Reiner’in İslâm’a ve Hz. Muhammed’e Yaklaşımı
Authors: Haliloğlu Fahrettin
Published: February 2025

Orientalist Julius Reiner’s Approach to Islam and the Prophet MuhammadrnThis study deals with Dr. Julius Reiner’s “Muhammad und der Islam”, written in German in 1907 by Dr. Julius Reiner, who lived between 1871-1930, and his approach to the Prophet Muhammad and Islam in the context of Siyer. It is seen that Reiner, who is an academician, displays misinformation and ideological approaches due to his prejudices about Islam and the Prophet in his work written in a popular style. For this reason, we have tried to analyze the parts of the work that we find especially problematic within the scope of Islamic History sources. In the first part of our study, both the meaning of the concepts of Orientalism and German Orientalism as well as their historical development were mentioned to the extent of our subject. In addition, Reiner’s life, his works and the works of orientalists, who were cornerstones in his time, on Siyer and Islamic history were discussed and the position of Reiner himself and his work was tried to be determined in this context. In the second part, Reiner’s comments on Islam, Qur’an, Sunnah and Ahl al-Kitab in his work and our evaluations in the context of these comments are presented. In the third part, Reiner’s views and evaluations on Jahiliyya, Mecca, Medina and the Prophet’s personality within the framework of his work and his criticism and analysis in terms of Siyar sources are included, and Reiner’s perception of the Prophet and Islam is tried to be determined.rnKeywords: Islamic History; Sira; Orientalism; German Orientalism; Kuraysh; Jews
Muhammed Emin Erbilî ve Tasavvufî Düşüncesi -Nakşibendiliğin Mı- sır'daki Öncüsü-
Authors: Akdoğan Mesut
Published: February 2025

Muhammad Amin Erbili and His Sufi Thought -The Pioneer of Naqshbandiyya in Egypt-rnMuhammed Amin Erbili is one of the important representatives of the Khalidi branch of the Naqshbandi order in the 19th and 20th centuries. Combining both exoteric and esoteric sciences, Erbili played a significant role in the revival and spread of Naqshbandism in Egypt. This study aims to introduce Muhammed Emin Erbili who lived during the late Ottoman period in regions such as Erbil, Hejaz, and Egypt, and to bring his Sufi thoughts to light and therefore contribute it to scholarly life. Indeed, the ideas of such individuals continue to illuminate the path of people, especially scholars, today, as they did in the past. Prepared by considering classical sources and academic studies, this work consists of an introduction and two main chapters. The introduction attempts to portray Naqshbandism and the political, social, and cultural context of the period to better understand Erbili. The first chapter focuses on his exemplary character, devoted to knowledge and spiritual enlightenment, by exploring his life. The second chapter delves into his Sufi thoughts, highlighting his contributions to contemporary knowledge and his lifelong dedication to learning and spiritual guidance, going beyond merely being a Naqshbandi guide. What inspired this study was Muhammed Emin Erbili’s scholarly and spiritual character, which adhered strictly to the Quran and the Prophetic Tradition (Sunnah), applied knowledge and wisdom in his life, and devoted himself entirely to learning and service. He was a scholar and mystic who fearlessly spoke and acted upon what he believed to be true. Alongside his Sufi identity, Erbilî was a distinguished scholar in the exoteric sciences, authoring numerous works in fields such as hadith, jurisprudence (fiqh), exegesis (tafsir), Quranic recitation (qira’at), and Sufism. Despite the challenging conditions of his time, he continued his spiritual guidance activities in Egypt, ensuring the spread of Naqshbandism in the region.rnKeywords: Sufism, Naqshbandi, Egypt, Muhammad Amin Erbili, Tanweer al-Quloob, Iraq.
İslamofobi Üzerine Öz Eleştirel Yaklaşım Radikalizm ve Ilımlılık Kıskacında Batı ve İslam Dünyasının Çıkmazı
Authors: Gür Ali
Published: February 2025

Self-Critical Approach To Islamophobia The Predicament of the West and the Islamic World in the Grip of Radicalism and ModerationrnIn this study, it is aimed to discuss the internal and external basic dynamics of Islamophobia from different perspectives, to reveal with examples how the West escalates Islamophobia with the radical structures it supports and how it aims to control Muslims with the imposition of moderate Islam, and to make Muslims self-criticize. In our recent era, the West has become dominant due to the East’s internal conflicts, corruption, drunkenness with power and missing the industrial revolution. The West, which gained power, imposed the philosophy that “the West is civilized, and the East is barbaric” in order to take revenge on the past. For fourteen centuries, what the West means by the East has always been Islam. On the one hand, they portray Muslims as pro-violence and terrorism with the radical Islamic structures they support, while on the other hand, they keep the Islamic world under control with the moderate Islamic structures they support in different geographies in order to protect their own imperial interests. The West uses all religion-based arguments, especially sectarian conflicts, to fuel Islamophobia. However, it is the Muslims themselves who give them this material and opportunity. In our study, three examples each from the many radical (Wahhabism, Islamic State of Iraq and Syria (DAESH), Boko Haram) and moderate structures (Fetullah Terrorist Organization (FETO), Tahir-ul Qadri, Kesnizani) that they support in different geographies of the Islamic World were examined in detail and their effects on the formation of Islamophobia were evaluated. It was discussed in detail how the Islamic world was atomized by fueling sectarian conflicts and sociocultural differences through these structures, how Muslims could be taken under control, regardless of whether they were radical or moderate, and how Muslims, who were constantly left in a defensive position, were rendered helpless. It was pointed out that the Islamic world, which constantly looks for the enemy outside, should question itself by self-criticism, that such structures, regardless of whether they are radical or moderate, may always have international connections and that we should always be on the alert against them.rn Keywords: Boko Haram, Fetullah Terrorist Organization, ISIS, Moderate Islam, Islamophobia, Radical Islam, Kesnizani, Salafism, Tahir- ul Qadri, Wahhabism
Şili’den Gibeah’a Kutsal Kitap Arkeolojisi
Authors: Bilkay Aslan
Published: February 2025

From Chile to Gibeah Biblical Archaeology -A Methodist Approach-rnBased on a 2024 master’s thesis submitted to Ibn Haldun University’s Graduate School of Graduate Studies, this book is an interdisciplinary study of biblical archaeology, which brings together the sciences of archaeology and the history of religions, and the archaeological excavations at Tell el-Fūl/Gibeah of Saul (1922- 23 and 1933) by William Foxwell Albright (d.1971), who gave this field its “golden age” with his important studies, from a Methodist perspective. The aim of the study is to demonstrate how Albright, from a Methodist perspective, utilized the science of archaeology to determine the accuracy of the biblical narrative through the example of his archaeological excavations at Tell el-Fūl/Gibeah of Saul. As a matter of fact, archaeology is one of the sciences from which the discipline of the history of religions makes the most use of its knowledge. Archaeology is a branch of science that investigates, records and tries to interpret the social, cultural and social life and order of human communities that lived in the past by focusing on the material remains that have survived to the present day. In its most general form, the term Bible refers to the books of the Old Testament and the New Testament, which are considered sacred by Jews and Christians. The term biblical archaeology, on the other hand, refers to the study of the peoples, cultures and eras described in the narratives of the Old and New Testaments through archaeological remains. This research, which examines biblical archaeology from a Methodist perspective through the example of the archaeological excavations conducted by W. Foxwell Albright at Tell el- Fūl/Gibeah of Saul, consists of an introduction and two chapters. The introduction deals with the purpose, significance, methodology, limitations, and sources of the study. The first part describes the Albright-centered archaeology of biblical archaeology. In other words, this chapter deals with the theoretical background of biblical archaeology, its historical development centered on Albright, the problem of nomenclature and its important schools. The second part of the book deals with William Foxwel Albrigt’s Methodist religious background, the biblical narrative of Gibeah, Albright’s archaeological excavations in the case of Tell el- Fūl/Gibeah of Saul in order to verify the accuracy of this narrative, and the subsequent criticisms of these archaeological studies.rnKeywords: Archaeological Excavation; Gibeah; Biblical Archaeology; Methodist; Tell el-Fūl; William Foxwell Albright
Reducción de la Dimensionalidad de un Sistema de Partículas en Movimiento Utilizando Redes Neuronales Convolucionales
Authors: Bertone Sergio E. , Puccini Gabriel D. , Bonetti Carlos A. , Denardi Melina , Bianchotti Jezabel D.
Published: February 2025

En el campo del aprendizaje automático, en los últimos años se ha desarrollado un enfoque innovador para modelar sistemas complejos mediante la identificación de dimensiones intrínsecas y variables de estado neuronales (NSV) utilizando redes neuronales convolucionales (CNN). Esta técnica ha demostrado ser eficaz en la predicción estable a largo plazo de sistemas dinámicos complejos, como los encontrados en aplicaciones industriales de flujos de materia granular. El presente trabajo se centra en el modelado y simulación de sistemas bidimensionales de partículas discretas en un entorno dinámico. Se emplean simulaciones computacionales para generar secuencias de video que capturan la dinámica del sistema en diversas configuraciones y velocidades. Estos datos se utilizan posteriormente para entrenar una red neuronal convolucional que funciona como un autoencoder, descomponiendo y reconstruyendo la señal de video. El proceso de descomposición implica una reducción de la dimensionalidad del sistema, lo que es crucial para obtener una representación más eficiente y simplificada de su comportamiento dinámico. Esto facilita la comprensión y predicción del sistema en entornos industriales. Se espera que los resultados obtenidos contribuyan al desarrollo de futuros modelos simplificados del sistema.
Consumer Engagement with Branded Mobile Applications: The Nexus of Brand Loyalty, Perceived Quality, and Brand Evangelism
Authors: Shabbir Javeria , Akhtar Shehla , Mohd Suki Norazah
Published: February 2025

This study aims to examine consumer engagement with branded mobile applications (apps) in terms of the impacts of brand loyalty, perceived quality, and brand evangelism. The partial least squares-structural equation modeling (PLS-SEM) approach was utilized for data analysis. This study confirmed that perceived quality had a positive impact on brand loyalty in consumer engagement with branded mobile apps. Consumers would consider specific branded mobile apps as their first choice and are loyal when they are of high quality. They also believe that branded mobile apps will be functional and dependable when used. As a result, they will not download other branded mobile apps that are similar to their preferred brand that are available at the online store. Marketers should emphasize the importance of brand loyalty in fostering brand evangelism among consumers, as perceived quality influences consumer brand loyalty, resulting in an increase in branded mobile apps’ consumer brand evangelism. The future research direction is also provided.
Important concepts to virtual reality
Authors: Darwish Dina
Published: February 2025

The term "virtual reality" (VR) refers to the interaction of a human being with a simulated world that has been produced via the deployment of computing technology, typically incorporating computer graphics and artificial intelligence. "Virtual" refers to anything that is imagined, whereas "reality" refers to something that is true. Within virtual reality, it is possible for a human to physically handle virtual things or animated objects. Many fascinating applications, such as, make advantage of the three-dimensional settings that are produced via the usage of virtual reality. VR includes training for driving automobiles and aeroplanes, as well as computer games and more applications. The word "augmented reality" is another concept that is sometimes mistaken with virtual reality (VR). For example, augmented reality is the incorporation of virtual items into the physical world. With virtual reality (VR), humans are placed in a simulated three-dimensional world, and they are able to truly experience the sound and sight of the three-dimensional scene, creating the illusion that it is a reality. One example of a virtual world is the game in which the main character in the film created, the kid interacts with it using a virtual reality headset and other equipment. This chapter discusses Virtual Reality main concepts, Virtual Reality experience, characteristics and components of a VR system.
Advanced topics in robotics
Authors: Manda Vijaya Kittu , Tarnanidis Theodore , Majeed Mohammed
Published: February 2025

Robotics is a futuristic multidisciplinary area to make machines think and work to accomplish specific tasks. It brings innovations from various engineering disciplines, such as computer science and artificial intelligence. The increasing number of research publications over the years shows that the topic interests’ researchers. This chapter explores six cutting-edge and emerging topics in robotics. A literature review and content analysis helped identify six advanced topics on robotics, which this chapter discussed. The topics included are Soft Robotics, Swarm Robotics, Human-Robot Interaction/Collaboration (HRI/HRC), integration of robotics with artificial intelligence, Micro and Nanorobotics, and quantum robotics. A list of 10 more advanced emerging areas of robotics is listed. This chapter identifies future research directions and provides a roadmap for academicians and practitioners to leverage these advancements for societal and industrial impact. This chapter helps academicians and professionals across various industries, especially in computer science, engineering, and electronic engineering, as well as practitioners from various industries focusing on technology applications such as healthcare, manufacturing, and exploration.
An over view on clitoria ternatea: An important medicinal plant
Authors: Lakshmi Ch Vasantha , T Vijaya
Published: February 2025

Clitoria ternatea is creeper of fabaceae family herb known for its medicinal properties and it is used as a memory booster, improves intellect, cure mental illness, antistress and anxiolytic agent from long ago and it is commonly used to cultivate as an ornamental species and is valued for its various medicinal applications. These plant flowers are edible and are particularly notable for their high concentration of anthocyanins and consume it as beverages and natural additive colour for food. Utilizing this legume for animal production can enhance nutritional intake while alleviating grazing pressure on natural habitats. This chapter discusses the distribution, botanical description, medicinal uses, phytochemical content, and other importance and its methods of propagation. In global climate change, C. ternatea exhibits several adaptation mechanisms that help it thrive in varying environmental conditions. Additionally, the plant contains essential phytochemical compounds beneficial for the pharmaceutical, textile, medicinal, and food industries.
Biofertilizers: A review on advancing sustainable agriculture and enhancing soil health
Authors: J Shakila Parvin , T Vijaya
Published: February 2025

Global population growth and rising food consumption pose significant challenges for agriculture which led to greater usage of inorganic fertilizers without considering soil health, which is crucial for achieving sustainable high yields. According to FAO (Food and Agriculture Organization) agricultural product consumption will increase by 60% by 2030. However, the increased usage of chemical fertilizers had a negative impact on the environment and living organisms. Moreover, the negative impacts of using inorganic fertilizers can be seen on the ecosystem, subsurface water sources, and soil microorganisms. Biofertilizers play a key role in replenishing the lost biological activity in soil due to the overuse of chemical fertilizers, as they consist of beneficial microorganisms that foster healthy interactions with plants in the rhizosphere. These interactions ultimately contribute to enhancing plant health, soil fertility, and long-term sustainability. They create growth-promoting chemicals and vitamins, maintaining soil fertility and suppressing pathogens and illnesses, leading to improved production and yield components. Biofertilizers are micro-organisms that improve productivity by fixing nitrogen, solubilizing phosphate and creating growth stimulants for plants. Biofertilizers are a cost-effective alternative to chemical fertilizers, reducing the significant investment required for fertilizer use. Biofertilizers provide a possible alternative to toxic chemicals, hence promoting agricultural sustainability.
Mangroves: Treasure of novel bioactive compounds
Authors: R Hadassa  , Kumari M Aruna , T Vijaya
Published: February 2025

Mangroves are unique coastal ecosystems found in tropical and subtropical regions, renowned for their ecological and economic importance. Beyond their role in protecting shorelines and supporting biodiversity, mangroves are a rich source of novel bioactive compounds with immense potential in medicine, agriculture, and industry. These compounds, including alkaloids, flavonoids, tannins, terpenoids, and phenolics, are produced as secondary metabolites to help mangroves thrive in extreme environments. They exhibit diverse biological activities such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and antifouling properties. Additionally, mangrove-associated microorganisms, such as fungi and bacteria, further contribute to the production of bioactive compounds with unique characteristics. The potential applications of these compounds span several fields: pharmaceuticals (drug discovery, antimicrobial agents, anticancer therapies), agriculture (biopesticides, biofertilizers, and plant growth enhancers), and environmental science (antifouling agents and bioremediation). Despite their promising benefits, challenges such as biodiversity loss, unsustainable harvesting, and limited research on their mechanisms of action must be addressed to harness their full potential.
Exploring bioaccumulation patterns and ecological risks of microplastics in aquatic ecosystems
Authors: Jamakala Obaiah , Chintada Vivek
Published: February 2025

Microplastics have emerged as a significant environmental concern, particularly in aquatic ecosystems. This chapter provides a comprehensive review of the bioaccumulation and ecological risk assessment of microplastics in aquatic environments. It begins with an overview of the characteristics and sources of microplastics, highlighting their prevalence in water bodies worldwide. The pathways through which microplastics enter and move through aquatic ecosystems are discussed, emphasizing the diverse sources such as plastic debris fragmentation, microbeads from personal care products, and synthetic fibers from textile materials. The chapter investigates the bioaccumulation of microplastics in various aquatic organisms, exploring how these synthetic particles are ingested, accumulated, and transported within food webs. The ecological risks associated with microplastics are analyzed, including impacts on aquatic life, ecosystem functioning, and potential effects on human health through the food chain. Methodologies for assessing ecological risks of microplastics are reviewed, encompassing both laboratory experiments and field studies that aim to quantify exposure levels and biological effects. Case studies and examples from different aquatic ecosystems are presented to provide real-world insights into the bioaccumulation patterns and ecological implications of microplastics. Lastly, the chapter discusses mitigation strategies and future directions for addressing the challenges posed by microplastics in aquatic environments, emphasizing the importance of interdisciplinary approaches and global cooperation to safeguard marine and freshwater ecosystems from this pervasive threat.
Quality Management Systems
Authors: T. Pawar Ruturaj , S. Mali Sachin , R. Veer Abhishek
Published: February 2025

Central Drug Standard Control Organization (CDSCO) and State Licensing Authority: Organization, Responsibilities, Certificate of Pharmaceutical Product (COPP), Regulatory requirements and approval procedures for New Drugs.
Cutaneous Anaplastic Large Cell Lymphoma: A Rare Thigh Localization
Authors: Essouni Zakaryae , Malak Ridah Salma , Neftah Ismail , Benbrahim Fatima Zohra , Belkouchi Lina , Allali Nazik , El Haddad Siham , Chat Latifa
Published: February 2025

Cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare type of non-Hodgkin lymphoma that primarily affects the skin. It accounts for a small percentage of cutaneous lymphomas and is characterized by solitary or multiple nodules, often localized, and rarely associated with systemic involvement. This condition is exceptionally rare in pediatric populations.
We report the case of a 13-year-old boy presenting with a painless swelling in the right thigh. Initial evaluation with ultrasound revealed a suspicious mass, prompting further investigation with a thoracoabdominal-pelvic (TAP) CT scan to better characterize the lesion and assess for potential additional sites. Histological analysis of a biopsy confirmed the diagnosis of cutaneous anaplastic large cell lymphoma. This case highlights the importance of early imaging and histological evaluation in the diagnosis of rare cutaneous lymphomas, especially in atypical pediatric presentations.
Rock Pools (Gnammas) in the Gibson Desert of Western Australia: Unique Formation and Reasons for Their Limited Biological Diversity
Authors: TIMMS BRIAN V. , HALSE STUART
Published: February 2025

Rock pools (gnammas) have a random distribution on rock pavements over much of Australia. In the climatically benign south, they are common and have a diverse fauna, but those in deserts are rarer, structurally different and scarcely surveyed. A widely spaced set of gnammas in the Gibson Desert of Western Australia were sampled in mid-2017 and again in mid-2018 using a pond net and a plankton net. The gnammas are in lateritic rock, and have a distinctive pipe-like form and mode of origin. The latter involves vertical solution of weathered rock, aided by kangaroos excavating for water as the pools dry. This is different from the granite pans and pits in southern Australia. Mean alpha diversity of macroinvertebrate communities in these mid-Western Australian gnammas is 5.9 species, drawn from a metacommunity of eight crustacean species, with perhaps a few insect individuals from an array of 21 species (gamma diversity). Invertebrate dispersal is extremely limited with crustaceans surviving dry periods as passively distributed eggs and insects recolonising actively from the wetter west during each filling event. Poor dispersal, plus the small size and homogeneity of habitat within the pipe gnammas, limits biotic diversity.
Inteligencia artificial: Un recurso para el diseño de campañas publicitarias
Authors: Ronquillo Alvarez Luz Marina , Recalde Henry
Published: February 2025

La era moderna está siendo la protagonista de varios avances tecnológicos, los sistemas informáticos han desarrollado mecanismos que facilitan las acti-vidades del ser humano, siendo la inteligencia artificial (IA) la principal he-rramienta tecnológica utilizada en los últimos años, debido al impacto gene-rado al momento de realizar actividades que en primera instancia solo la inte-ligencia humana podía realizar.
La IA se ha expandido en distintos ámbitos, su dinamismo y versatilidad la convierte en un recurso idóneo para el diseño de campañas publicitarias. Su capacidad automatizada para dar respuesta a los requerimientos del área de marketing y comunicación la convierten en un aliado estratégico para el aná-lisis de mercado y creación de contenido de valor para incitar a las personas a consumir determinado producto/servicio o se conviertan en los actores que facilitan la consecución de objetivos de las marcas. Las empresas e institu-ciones consideran a la IA como un medio innovador que contribuye al posi-cionamiento de sus marcas y les permite competir en un mercado local e in-ternacional con un alto índice de calidad. En este sentido, este trabajo realiza una revisión sistemática de literatura sobre la inteligencia artificial como un recurso para el diseño de campañas publicitarias; se utiliza el Frameworks SALSA, que consta de cuatro pasos claves para identificar la situación actual del tema.
PERCEPTIONS OF NURSES AND PATIENTS REGARDING POST-CORONARY ARTERY BYPASS GRAFT
Authors: Javed Saqib , Aman Ullah  , Safdar Andaleeb , Gulbud Din  , Imdad Ullah  , Bibi Afrooz , Khan Nasar , Muhammad Wasim , Ahmad Tufail , Kashif Muhammad
Published: February 2025

Background: Coronary artery bypass graft (CABG) is a critical surgical intervention for patients with coronary artery disease, requiring extensive postoperative care and education to prevent complications and ensure optimal recovery. Adequate patient education before discharge significantly influences adherence to treatment, self-care practices, and long-term health outcomes. However, discrepancies often exist between the perceived learning needs of patients and the educational priorities of healthcare providers, highlighting the necessity of evaluating these perspectives to enhance patient-centered care.
Objective: This study aimed to assess and compare the perceived learning needs of post-CABG patients and nurses to develop a structured educational approach that addresses patient-specific concerns before hospital discharge.
Methods: A cross-sectional study was conducted at Peshawar Institute of Cardiology and the Cardiac Rehabilitation Center (CRC) at Hayatabad Medical Complex. A total of 180 participants, including 90 post-CABG patients and 90 registered nurses, were enrolled using non-probability convenience sampling. Data were collected using the Modified Cardiac Patients Learning Needs Inventory (MCPLNI) questionnaire. Descriptive statistics and the chi-square test were applied using the Statistical Package for the Social Sciences (SPSS) to analyze the responses.
Results: Patients ranked chest and lower limb wound care (4.3 ± 0.516), dietary information (4.3 ± 1.328), and postoperative complications (4.3 ± 1.823) as their highest learning priorities, whereas nurses placed greater emphasis on wound care (4.2 ± 0.824), medication management (4.0 ± 0.514), and dietary guidance (4.0 ± 0.591). The domain of "Introduction to the Cardiac Unit" was perceived as moderately important by patients (3.55 ± 0.713). Differences in ranking highlight a gap between patient and nurse perspectives on educational needs.
Conclusion: The findings indicate a disparity between patient and nurse perceptions of post-CABG educational needs, emphasizing the necessity of incorporating patient preferences into discharge planning. Structured educational programs tailored to patient concerns can enhance postoperative recovery and reduce complications.
INVESTIGATING THE ROLE OF GINGER TEA ORAC VALUE IN HYPERTENSION MANAGEMENT
Authors: Taskeen Sehar , Hafeez Muhammad Adnan , Ikram Iqra
Published: February 2025

Background: Hypertension is a leading modifiable risk factor for cardiovascular diseases, including ischemic heart disease, stroke, and chronic kidney disease, and remains a major cause of global morbidity and mortality. Despite pharmacological advancements, dietary and lifestyle interventions play a crucial role in its management. Ginger, a bioactive-rich plant with high Oxygen Radical Absorbance Capacity (ORAC), has been recognized for its potential cardiovascular benefits. This study investigates the efficacy of ORAC-rich ginger tea in reducing blood pressure, improving lipid profiles, and enhancing arterial compliance in hypertensive individuals.
Objective: To evaluate the impact of ginger tea consumption on systolic and diastolic blood pressure, lipid profile parameters, and arterial stiffness as an adjunct to conventional hypertension management.
Methods: This single-blinded randomized controlled trial was conducted in outpatient clinics of a university hospital. A total of 50 participants aged 30-65 years with stage 1 or stage 2 hypertension were randomly assigned to either the intervention group (n=25), receiving ginger tea (2 g ginger root powder steeped in 250 mL hot water daily for 12 weeks), or the control group (n=25), receiving placebo tea. Blood pressure, total cholesterol, LDL/HDL cholesterol, triglycerides, and arterial stiffness (measured via pulse wave velocity) were assessed at baseline and after 12 weeks. Statistical analysis was performed using the Wilcoxon Signed Rank and Mann-Whitney U tests, with significance set at p<0.05.
Results: The intervention group exhibited a significant reduction in systolic blood pressure (135.2 ± 12.4 mmHg to 126.0 ± 9.8 mmHg, p=0.006) and diastolic blood pressure (85.4 ± 8.7 mmHg to 78.5 ± 7.2 mmHg, p=0.010). Total cholesterol levels declined from 210.1 ± 22.0 mg/dL to 190.5 ± 18.4 mg/dL (p=0.004), while LDL cholesterol decreased from 140.4 ± 18.7 mg/dL to 125.6 ± 15.7 mg/dL (p=0.011). HDL cholesterol increased significantly from 52.1 ± 7.0 mg/dL to 58.5 ± 6.2 mg/dL (p=0.005). Pulse wave velocity improved from 8.5 ± 1.3 m/s to 7.5 ± 1.0 m/s (p=0.009), suggesting enhanced arterial flexibility.
Conclusion: Ginger tea demonstrated significant antihypertensive and lipid-lowering effects, supporting its role as a natural adjunct to hypertension management. Its high antioxidant capacity contributes to cardiovascular benefits, making it a promising dietary supplement alongside standard pharmacotherapy. Further research is warranted to explore its long-term efficacy and broader clinical applications.
Penerapan Aplikasi Akuntansi UKM Pada Perusahaan/UMKM
Authors: Nurhasanah Siti , Wahyu Setiaji Bagus , Saputra Bima , Darni Darni
Published: February 2025

Penelitian memiliki tujuan umum untuk mengembangkan aplikasi akuntansi sederhana untuk mengetahui kemampuan yang dimiliki aplikasi tersebut sehingga dapat memberikan informasi yang valid. Penelitian ini menggunakan metodologi pemecahan masalah, yang mendorong pertanyaan tentang bagaimana mengembangkan perangkat lunak khusus untuk digunakan dalam mengatasi masalah dengan laporan keuangan yang dihadapi oleh berbagai jenis organisasi dan perusahaan. Penelitian ini mengarah pada implementasi perangkat lunak akuntansi usaha kecil dan menengah yang mengikuti pendekatan siklus transaksi, termasuk langkah-langkah berikut: merancang siklus transaksi (pembelian, penjualan, dan uang tunai), membuat jurnal (penjualan, pembelian, penerimaan dan pengeluaran kas, umum), buku besar, laporan keuangan, neraca penutupan akhir. Hasil pengujian menunjukkan bahwa aplikasi Akuntansi UKM berdasarkan metode siklus transaksi dapat memberikan data yang handal, sehingga menimbulkan harapan bahwa UMKM akan dapat memanfaatkan aplikasi berbasis akuntansi ini. Fondasi di mana laporan keuangan dibangun, tentunya menurut SAK UMKM serta memudahkan dalam Mengimplemestasikan Akuntansi serta peningkatan profit usaha yang sedang dijalani