bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Algoritma Sequential Search pada Aplikasi Kamus Bahasa Ilmiah Tumbuhan
Authors: Rahmanto Yuri , Alfian Joni , Damayanti Damayanti , Borman Rohmat Indra
Published: May 2021

Abstract. Application of Sequential Search Algorithms in the Plant Scientific Language Dictionary Application. Scientific dictionaries such as plants dictionaries are thick and less attractive. Therefore, it is necessary to develop a scientific language dictionary application for plant which is attractive and can be accessed anytime and anywhere. The dictionary application is closely related to the search feature and the sequential search algorithm is used in the search feature at the application development. This algorithm performs the search by matching data in a row from all existing data. The application built had features such as a list of plants with scientific names equipped with A-Z alphabet menus, plant categories, and a search feature to make it easier for users to find the plant names. The results of the search speed performance test based on page load time with the microtime function show that sequential search algorithms can perform the searches quickly for relatively limited and not too much data.Keywords: Scientific Language Dictionary, Plant Dictionary, Sequential Search Abstrak. Kamus ilmiah seperti kamus ilmiah tumbuhan berbentuk tebal dan kurang menarik. Oleh karena itu, diperlukan pengembangan aplikasi kamus Bahasa ilmiah tumbuhan yang menarik dan dapat diakses kapanpun dan dimanapun. Aplikasi kamus akan berhubungan erat dengan pencarian dan algoritma sequential search digunakan sebagai fitur pencarian pada pengembangan aplikasi kamus bahasa ilmiah tumbuhan ini. Algoritma ini melakukan pencarian dengan mecocokan data secara beruntun dari seluruh data yang ada. Aplikasi yang dibangun memiliki fitur-fitur seperti daftar tumbuhan dengan nama ilmiah yang dilengkapi menu abjad A-Z ,  kategori tumbuhan, dan fitur pencarian untuk memudahkan pengguna dalam menemukan nama tumbuhan. Hasil pengujian kecepatan pencarian berdasarkan page load time dengan fungsi microtime menunjukkan bahwa algortima sequential search dapat melakukan pencarian dengan cepat untuk data yang relatif terbatas atau tidak terlalu banyak.Kata Kunci: Kamus Bahasa Ilmiah, Kamus Tumbuhan, Sequential Search
Designing User Experience Design of the Healthy Diet Mobile Application Using the Fives Planes Framework
Authors: Agusdin Riza Prapascatama , Salsabila Amira , Kartika Putri Dyah Anggraini
Published: May 2021

Abstract. Obesity and overweight are becoming increasingly common conditions. On the other hand, the rapid development of technology shows by the increasing number of smartphone users. M-health application can be a solution to the burden of existing health problems. In line with that, the research focused on the quality improvement of user experience in m-Health, especially diet-related apps widely conducted. This study aims to design user experience in a diet-support mobile application called Health-Key using the five planes framework by evaluating usability aspects using the User Acceptance Test. The result of this study is prototype design. Evaluation shows that the designed prototype has good interface, practicality, and efficiency indicator, and 76.9% of respondents stated that the application is feasible, appropriate, useful, and it potentially developed in further iteration with improvements according to the respondents' suggestions.Keywords: m-health, healthy diet, user experience, five planes framework, user acceptance test. Abstrak. Designing User Experience Design of The Healthy Diet Mobile Application Using The Fives Planes Framework. Obesitas dan kelebihan berat badan menjadi kondisi gangguan kesehatan yang umum dialami. Di sisi lain, perkembangan teknologi yang kian pesat ditunjukkan dengan semakin banyaknya pengguna smartphone. Aplikasi M-Health (Mobile Health) dapat menjadi solusi dari beban permasalahan kesehatan yang ada. Sejalan dengan itu, penelitian yang berfokus pada peningkatan kualitas pengalaman pengguna M-Health, khususnya aplikasi pendukung diet, banyak dilakukan. Penelitian ini bertujuan untuk merancang desain pengalaman pengguna dalam aplikasi mobile yang mendukung pola diet sehat bernama Health-Key menggunakan The Fine Planes Framework serta mengkombinasikannya denga mengevaluasi aspek kegunaan dengan User Acceptance Test. Hasil dari penelitian ini adalah desain prototipe. Evaluasi menunjukkan bahwa prototipe yang dirancang memiliki indikator antarmuka, kepraktisan, dan efisiensi yang baik, serta 76,9% responden menyatakan bahwa aplikasi layak, tepat-guna, bermanfaat, dan berpotensi dikembangkan dalam iterasi perancangan lebih lanjut dengan perbaikan sesuai saran responden.Kata Kunci: m-health, healthy diet, user experience, five planes framework, user acceptance test.
Ekstraksi Informasi Terstruktur Profil Pengguna Website Iklan Baris
Authors: Cahyono Nuri
Published: May 2021

Abstract. Extraction of Structured Information on Classified Ads Website User Profiles. The large amount of user data published on online buying and selling sites provides benefits for research and digital marketing. Data extraction was a method for obtaining data from publicly published website content. The first step was to determine the website category that was needed, then determined the attributes to be used as a reference in compiling the data extraction tags. The next step was to identify the tags that were taken based on the tag elements of the website that matched these attributes. Elements to compile tag extraction included CSS Selector, HTML Tag and Xpath. Based on this, a data extraction code was created with four iterations based on categories. The test was done by calculating the accuracy to find out the complete amount of extracted data. From a total of 16,000 data extracted in this test, the accuracy rate was 99.0625%.Keywords: Data Extraction, Web Scrapping, Classified Ads Abstrak. Perkembangan situs jual beli online berdampak pada banyaknya data pengguna yang dipublikasikan secara online. Profil pengguna situs web memiliki banyak manfaat baik untuk penelitian maupun untuk tujuan dalam pemasaran digital. Ekstraksi data adalah mekanisme untuk mendapatkan data dari konten situs web yang disajikan secara umum. Langkah pertama adalah menentukan kategori website kemudian menentukan atribut yang akan digunakan sebagai acuan dalam menyusun tag ekstraksi data yang diambil berdasarkan elemen tag dari website yang sesuai dengan atribut tersebut. Elemen tag yang diambil untuk menyusun tag ekstraksi antara lain CSS Selector, HTML Tag dan Xpath, kemudian dibuat skenario ekstraksi data dengan skenario empat kasus berdasarkan kategori yang telah ditentukan. Pengujian dilakukan dengan menghitung akurasi untuk mengetahui jumlah data yang berhasil di dapatkan secara lengkap. Dari total 16000 data dari hasil ekstraksi, dalam pengujian ini menghasilkan tingkat akurasi 99.0625%.Kata Kunci: Ekstraksi Data, Web Scrapping, Iklan Baris
Joint-stock form of corporate control: features of the formation and functioning of its civil-law mechanisms
Authors: Goncharov Vitaly Viktorovich , Afanasev Nurgun V. , Shpinev Iurii S.
Published: May 2021

This article is devoted to the research of civil law mechanisms for the formation and implementation of a joint-stock form of corporate control in the Russian Federation. According to the authors, the joint-stock form of corporate control is the most important form of influence on participants in corporate legal relations from the shareholders of joint-stock companies. The paper examines the influence of the joint-stock form of corporate control on the functioning of joint-stock companies as the most important form of corporate organizations in Russia.
DAMPAK PERCERAIAN ORANG TUA PADA PRESTASI ANAK REMAJA
Authors: Jenz Febriyani , Apsari Nurliana Cipta
Published: May 2021

ABSTRAKBanyak kasus perceraian terjadi belakangan ini. Perceraian tidak hanya berdampak pada orang tua yang bercerai saja, melainkan juga berdampak pada anak remaja. Sedangkan, anak masih menjadi tanggung jawab orang tua yang butuh diberi perhatian lebih. Dampak dari perceraian inilah yang juga menyebabkan menurunnya prestasi pada anak. Untuk itu, orang tua harus lebih jeli dalam memperhatikan kebutuhan anak, sehingga dampak perceraian pada anak dapat diminimalisir. Dalam penelitian ini, peneliti menerapkan penelitian kualitatif dengan metode deskriptif yang menjelaskan tentang pengaruh perceraian orang tua terhadap prestasi belajar pada anak remaja. Tujuan penelitian ini adalah untuk mengetahui pengaruh perceraian terhadap prestasi belajar pada remaja  ABSTRACT Many divorce cases have occurred lately. Divorce not only affects the parents who are divorcing, but also affects adolescents. Meanwhile, children are still the responsibility of parents who need more attention. The impact of divorce is what also causes decreased achievement in children. For this reason, parents must be more observant in paying attention to children's needs, so that the impact of divorce on children can be minimized. In this study, researchers applied qualitative research with descriptive methods which explained the effect of parental divorce on learning achievement in adolescents. The purpose of this study was to determine the effect of divorce on learning achievement in adolescents
FAKTOR PENYEBAB TERJADINYA KEKERASAN DALAM RUMAH TANGGA TERHADAP PEREMPUAN
Authors: Alimi Rosma , Nurwati Nunung
Published: May 2021

ABSTRAKKekerasan memang tidak memandang gender, namun terlihat sangat jelas dari data yang disajikan bahwa kekerasan terhadap perempuan sangatlah mengkhawatirkan. Konflik yang tidak kian usai dapat menimbulkan Kekerasan Dalam Rumah Tangga (KDRT). Tingkat KDRT yang setiap tahunnya cenderung meningkat menandakan bahwa korban mulai menyadari bahwa tindak KDRT bukanlah sesuatu yang dapat dinormalisasi, sehingga korban memiliki hak untuk memperjuangkan hak hidup aman dan lebih baik. Pernikahan yang seharusnya menjadi sebuah ruang yang nyaman untuk sepasang manusia, justru menjadi ruang paling menakutkan bagi sebagian perempuan. Adapun faktor-faktor terjadinya kekerasan terhadap perempuan dalam rumah tangga khususnya yang dilakukan oleh suami terhadap istri sangatlah beragam. KDRT merupakan sebuah perilaku yang memberikan dampak yang sangat kompleks terhadap perempuan korban KDRT. Tindak kekerasan tersebut menghasilkan dampak psikologis terhadap perempuan korban KDRT. Salah satu upaya penanganan yaitu adanya pemenuhan hak terhadap perempuan korban KDRT. Pemahaman budaya kesetaraan sangat dibutuhkan dalam kehidupan berpasangan, keluarga, maupun masyarakat. Dengan fakta, data, dan aturan dalam Undang-Undang yang sudah ada dan ditetapkan, seharusnya pemerintah dan lembaga-lembaga anti kekerasan terhadap perempuan dapat bergerak lebih luwes lagi untuk membantu dan melindungi perempuan korban kekerasan ABSTRACTViolence is not see gender, but is clearly evident from the data presented above that violence against women is alarming. After the conflict he could cause domestic violence. The domestic violence which annually tended to increase indicates that starting to realize that victims of domestic violence is not something that can be normalized, the victim has a right to safe enforcing their rights and better. Marriage should be a room that is comfortable for a pair of men, have been the most terrifying for some women. As for the causes of domestic violence against women particularly those undertaken by the husband against the wife is very diverse. Behavior that domestic violence is a very complex impact the victims of domestic violence against women. Psychological violence resulted in the impact the victims of domestic violence against women. One of efforts to handle the fulfillment of the rights of the victims of domestic violence against women. Understanding culture equality is needed in the life of in pairs, family, and the community. To the fact, data, and rules in a law that was and set, the government should and institutions anti violence against women can move more flexible again to help and protect women a victim of violence.
DAMPAK PERNIKAHAN USIA DINI TERHADAP KESEHATAN REPRODUKSI
Authors: Sekarayu Shafa Yuandina , Nurwati Nunung
Published: May 2021

ABSTRAKPernikahan merupakan ikatan lahir dan batin berupa penyatuan antara laki-laki dan perempuan atas dasar keinginan untuk memiliki keturunan dan keluarga. Pada dasarnya pernikahan dilakukan oleh seseorang yang telah memiliki kematangan dalam segi fisik, psikologis, dan ekonomi. Namun, di Indonesia sekitar 12 - 20% masih bisa ditemukan pernikahan yang belum disertai dengan kesiapan dari berbagai aspek seperti fisik, ekonomi, dan pengetahuan mengenai kehidupan rumah tangga. Artikel ini menggunakan metode penelitian kualitatif dan deskriptif yang akan menggali lebih dalam mengenai pernikahan dini dan keterkaitannya dengan kesehatan reproduksi. Pernikahan usia dini dilakukan oleh seseorang yang rata-rata berusia dibawah 19 tahun yang rata-rata belum siap dalam berbagai aspek dalam pernikahan. Hal ini kemungkinan akan berdampak terhadap kesehatan reproduksi baik untuk perempuan maupun laki-laki. Oleh karena itu, diperlukan persiapan yang dari berbagai aspek dalam melaksanakan pernikahan sehingga upaya untuk menghindari dampak buruk pernikahan usia dini terhadap kesehatan reproduksi dapat diminimalisir. ABSTRACT Marriage is a physical and spiritual bond in the form of a union between a man and a woman based on the desire to have offspring and a family. Basically, marriage is carried out by someone who has matured physically, psychologically and economically. However, in Indonesia, around 12-20% can still be found marriages that have not been accompanied by readiness from various aspects such as physical, economic, and knowledge of household life. This article uses qualitative and descriptive research methods that will explore more about early marriage and its relation to reproductive health. Early marriage is carried out by someone who is under 19 years old on average who is not ready for various aspects of marriage. This is likely to have an impact on reproductive health for both women and men. Therefore, various aspects of preparation are needed in carrying out the marriage so that efforts to avoid the negative impact of early marriage on reproductive health can be minimized.
PENGUATAN MASYARAKAT DI MASA PANDEMI COVID 19: KESEHATAN MENTAL PELAJAR
Authors: Raharjo Santoso Tri
Published: May 2021

AbstrakPenguatan masyarakat yang menjalan proses adaptasi di tengah situasi dan dampak Pandemi Covid 19 menjadi hal penting saat ini. Banyak masyarakat yang terdampak dengan situasi pandemi saat, ada yang berhasil dan ada yang memerlukan pertolongan dan penguatan. Keperdulian di antara sesama anggota masyarakat sangat diperlukan dalam menghadapi bencana non alam ini. Tidak terkecuali dengan pihak perguruan tinggi, dalam hal ini civitas akademika Universitas Padjadjaran, dengan berbagai sumber daya yang dimiliki dapat mengambil peran penting memperkuat kemampuan masyarakat agara dapat menjalani kehidupan di tengah pandemi cobid 19 ini. Berbagai program dan kegiatan keperdulian pengabdian masyarakat dapat diintegrasikan dengan pembelajaran dan riset. Salah satunya melalui kuliah kerja nyata mahasiswa (KKNM), walaupun dilaksanakan secara virtual. Pemberian informasi dan pengetahuan mengenai pola hidup sehat dan bersih (PHBS) atau penerapan protokol kesehatan (prokes) untuk mencegah penyebaran Covid-19, merupakan salah satu bentuk dari upaya memperkuat kelompok-kelompok masyarakat. Demikan pula dengan cara-cara menghadapi situasi pemberitaan tentang pandemi secara jernih, serta memilah pemberitaan yang valid agar tidak mengganggu kestabilan mental. Hal ini juga merupakan aspek perlu diperkuat, apalagi di era dijital yang makin masif dan kemajuan teknologi informasi dan penggunaan media sosial massal. AbstractStrengthening people who undergo the adaptation process amidst the situation and the impact of the Covid 19 Pandemic is currently important. Many people were affected by the current pandemic situation, both in the economic, education and health sectors, some were successful and some needed help and strengthening. Concern among fellow community members is needed in dealing with this non-natural disaster. The higher education institutions are no exception, in this case the Padjadjaran University academic community, with its various resources, can play an important role in strengthening the ability of the community so that they can live life in the midst of this Cobid 19 pandemic. Various community service programs and activities can be integrated with learning and research. One of them is through student real work lectures (KKNM), although it is implemented virtually. Providing information and knowledge about healthy and clean lifestyles (PHBS) or the application of health protocols (prokes) to prevent the spread of Covid-19, is one form of efforts to strengthen community groups. Likewise, by dealing with the news situation about the pandemic clearly, and sorting out valid news so as not to disturb mental stability. This is also an aspect that needs to be strengthened, especially in the increasingly massive digital era and advances in information technology and the use of mass social media.
Early Repolarization Pattern and Idiopatic Sustained Monomorphic Ventricular Tachycardia: an Infrequent Combination
Authors: Vásquez Javier Pinos , Leiria Tiago Luiz Luz , Kruse Marcelo Lapa , Lima Gustavo Glotz de
Published: May 2021

Malignant early repolarization as cause of sudden death has taken on great importance in recent years. It has been described as an entity capable of producing ventricular arrhythmic events, causing from episodes of syncope to sudden cardiac death. Ventricular fibrillation is the typical arrhythmia in these patients, with no clear relationship to date with idiopathic monomorphic ventricular tachycardia. Electrocardiographic markers related to the development of arrhythmic events in early repolarization syndrome have been described. They seem not only related to the development of ventricular fibrillation, but also to sustained monomorphic ventricular tachycardia, as is the case described in the article.
Percutaneous Treatment to Inferior Vena Cava Perforation by Intracardiac Echocardiography Catheter after an Unsuccessful Conservative Approach
Authors: Vassallo Fabricio , França Rodrigo , Lovatto Carlos Volponi , Carvalho Bruno , Cardoso Alessandra , Cunha Christiano Lemos da
Published: May 2021

Catheter ablation is a well-established treatment for drug refractory arrhythmia, and intracardiac echocardiography is one of the tools used for this purpose. Despite a high volume of procedures performed worldwide, the incidence of vascular complications is still very low. We describe a case report of a percutaneous treatment to an inferior vena cava perforation by an intracardiac echocardiogram catheter after the failure of a conservative approach.
Persistence of Left Superior Vena Cava in Nonagenarian Undergoing Pacemaker Implant: Case Report
Authors: Oliveira Lucas Hollanda , Luize Christian Moreno , Carvalho Ricardo Sobral de , Carvalho Marcel Fernando Silva , Lago Danusa Moreira , Dietrich Cristiano de Oliveira , Cirenza Claudio
Published: May 2021

Introduction: The persistence of the left superior vena cava (PLSVC) is a congenital malformation of the veins that drain blood from the upper body, causing the flow to the right atrium to be processed through the coronary sinus. Case report: We describe the case of a nonagenarian woman, previously asymptomatic until she developed total atrioventricular block when she was referred for implantation of a double chamber pacemaker. Persistence of the left superior vena cava was detected during the procedure and confirmed by venography. The implantation of the electrodes was performed safely and without complications. Conclusion: Despite not usually causing symptoms, the presence of PLSVC can make invasive procedures a challenging task. Knowledge of anatomy and the use of simple techniques can facilitate interventions in this scenario.
Long-term persistent mixed chimerism in a patient with Wiskott–Aldrich syndrome after allogeneic hematopoietic stem cell transplantation
Authors: Bludova V. О. , Laberko A. L. , Rodina Yu. A. , Brilliantova V. V. , Raykina E. V. , Khoreva A. L. , Pershin D. E. , Tereshchenko G. V. , Shcherbina A. Yu.
Published: May 2021

The article describes a clinical case of a patient with Wiskott–Aldrich syndrome, in whom long- term persistence of mixed chimerism was determined after hematopoietic stem cell transplantation (HSCT) from a haploidentical donor. Based on the analysis of the patient's clinical picture after HSCT, it was shown that the presence of> 50% of donor cells in the myeloid lineage is necessary for the correction of thrombocytopenia. In addition, the presence of mixed chimerism in B-lymphocytes possibly contributed to the development of autoimmune complications in the patient, as well as to the persistent hypogammaglobulinemia, despite the restoration of the normal numbers of lymphocytes in all main sub-populations. The role of mixed chimerism in the pathogenesis of immune post-transplant complications requires study in large groups of patients with primary immunodeficiencies. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.
Modern treatment of infantile hemangioma
Authors: Khachatryan L. A. , Nikolaeva D. M.
Published: May 2021

Infantile hemangioma (IH) is the most common benign vascular tumor in children of the first year, which is based on abnormal proliferation of endothelial cells under the influence of the main pro-angiogenic factors: vascular endothelial growth factor (VEGF) and fibroblast growth factors (FGF). It develops in the first weeks after birth, forming over 3–9 months with regression in the next 3–7 years. Three-quarters of infantile hemangiomas are nodular and are not accompanied by malformations. At the same time, segmental IH is most often associated with syndromic forms. Despite spontaneous regression (in 90% of cases), some forms and localization of IH can lead to the development of complications, local and endangering vital functions. In most cases, the diagnosis is based on anamnesis, characteristic features of the tumor, and clinical course. Additional studies (ultrasound DG, MRI/CT, biopsy) are necessary in complicated forms and in doubtful clinical cases.
The fist experience of using locally manufactured CAR-T cells in patients with relapsed/refractory acute lymphoblastic leukemia in Belarus
Authors: Aleinikova O. V. , Migas A. A. , Stolyarova E. A. , Punko A. V. , Movchan L. V. , Klych A. V. , Mishkova O. A. , Hill A. V. , Meleshko A. N. , Konoplya N. E.
Published: May 2021

The results of treatment of recurrent/refractory acute lymphoblastic leukemia (ALL) with both standard and high-dose chemotherapy are unsatisfactory and require the development of new therapeutic options. The use of immunotherapy approaches opens up new perspectives for patients whose cytotoxic chemotherapy was ineffctive or intolerable. This article describes the experience of using CD19 CAR-T cells manufactured at the Republican Scientifi and Practical Center for Pediatric Oncology, Hematology and Immunology after lymphodepletion with fldarabine and cyclophosphamide in two patients over 18 years of age with refractory relapse of ALL. Other possibilities of conservative treatment for these patients have been exhausted. The study was approved by the Independent Ethics Committee and the Scientifi Council of the Belarusian Research Center for Pediatric Oncology, Hematology and Immunology (Republic of Belarus). The chimeric 2nd generation receptor was constructed from the anti-CD19 scFv antibody fragment, the CD28 transmembrane domain, signaling domains of the 4-1BB and CD3z proteins, and transduced into T-lymphocytes as part of the pWPXL lentiviral vector. The cell product was obtained by separation and separate processing of CD4 and CD8 lymphocytes in the presence of IL-7 and IL-15. The subpopulation composition of the resulting CAR-T cell product and the expression of immune checkpoints were assessed. The results obtained indicate a high antileukemic activity of the obtained CAR-T cells. Monitoring of CAR-T cells' persistence, the level of minimal residual disease, and the spectrum of inflmmatory cytokines in the blood was performed. Both patients responded to CAR-T therapy by lowering their blast cell levels. Treatment was accompanied by a cytokine release syndrome controlled by a recombinant monoclonal antibody to the human IL-6 receptor, tocilizumab. The developed and replicated laboratory-derived CAR-T cell technology can be used to treat patients with severe relapsed/refractory B-line ALL as rescue therapy and provide additional chances for their cure.
Health assessment in patients with autosomal recessive osteopetrosis before and after allogeneic hematopoietic stem cell transplantation
Authors: Burya A. E. , Machneva E. B. , Melnikova M. B. , Skorobogatova E. V.
Published: May 2021

Here we report the results of long-term monitoring of children with malignant infantile osteopetrosis (MIOP) before and after a successful hematopoietic stem cell transplantation (HSCT). We present patient health data collected 3-6 years after the completion of treatment, including information on the children's physical and mental health and social adaptation. The study was approved by the Independent Ethics Committee and the Scientifi Council of the N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation. HSCT is the only currently available radical treatment for MIOP. At the time of the treatment, all the patients exhibited severe visual impairment (descending optic atrophy), transfusiondependent bone marrow dysfunction, hepatosplenomegaly, signifiant skeletal abnormalities and growth retardation. In this study, we included 5 MIOP patients with successful transplantation who had been treated from 2014 to 2018. Four patients underwent HSCT from unrelated 10/10 HLA-identical donors and 1 patient received HSCT from a related 10/10 HLA-identical donor. The ratio of boys to girls was 2:3, the median age at the time of the transplantation was 7 (2–11) years. All the patients demonstrated full donor chimerism after HSCT. Hematopoietic recovery was achieved within the fist 150 days after HSCT. Radiological investigations showed gradual partial reduction of skeletal changes typical of MIOP. All the subjects demonstrated growth of the axial skeleton, facial bone remodeling and abatement of phenotypic features of the disease. The patients' vision remained the same as before HSCT. All the patients reported that their health and quality of life had improved after HSCT. The degree of visual impairment had a substantial impact on the quality of life and social rehabilitation of the patients. The second major factor affcting the quality of life was the development of chronic conditions after HSCT, namely, epilepsy and chronic “graft-versus-host” disease of the lung that require constant medical monitoring and limit rehabilitation potential. The patients' parents gave their consent to the use of their children's data, including photographs, for research purposes and in publications.
Platelet phenotype in children with ANKRD26-related thrombocytopenia
Authors: Polokhov D. M. , Fedorova D. V. , Pshonkin A. V. , Ignatova A. A. , Ponomarenko E. A. , Aleksenko M. Yu. , Mersiyanova I. V. , Seregina E. A. , Voronin K. A. , Poletaev A. V. , Raykina E. V. , Panteleev M. A. , Zharkov P. A.
Published: May 2021

The mechanisms of hemorrhagic manifestations in patients with ANKRD26associated thrombocytopenia (ANKRD26-AT) are poorly understood. The aim of this work is to detect possible morpho-functional disorders of platelets in patients with mutations in the ANKRD26gene by flow cytometry with activation. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. 8 children aged from 1.5 to 15 years were examined. The platelet count ranged from 29 to 172 thousand/μl, with a median of 60 thousand/μl. The severity of hemorrhagic manifestations was assessed on a standardized scale (Pediatric Bleeding Questionnaire, PBQ) and it ranged from 0 to 5 points, with a median of 3.5 points. Platelet activation was performed with a CRP + TRAP mixture. Comparison was carried out with the results of examination of 26 apparently healthy children (control group, CG) aged 2 to 15 years. When compared with CG, patients showed an increase in platelet size (FSC; p= 0.018) and granularity (SSC; p< 0.001) after activation. In contrast to the CG, the correlation between FSC and SSC of platelets in patients was not significant (cor. = 0.55; p= 0.15). Patients showed a high, significant relationship between the number and FSC of platelets (cor. = –0.93; p< 0.001), as well as an increased density of CD42b (p < 0.001) and a decrease in the proportion of procoagulant platelets (p= 0.01) after activation. The revealed changes indicate violations of the mechanisms of activation and shape changes of platelets in patients with ANKRD26-AT.
Evans syndrome in children: the results of a retrospective study of 54 patients
Authors: Kuzminova Z. A. , Pshonkin A. V. , Raikina E. V. , Pavlova A. V. , Kurnikova M. A. , Mersiyanova I. V. , Suntsova E. V. , Shvets O. A. , Mukhina A. A. , Kuzmenko N. B. , Shcherbina A. Yu. , Maschan A. A. , Smetanina N. S.
Published: May 2021

Evans syndrome (ES) is a rare disorder accompanied by autoimmune hemolytic anemia and immune thrombocytopenia. ES in children is often associated with the defect of immune system regulation. This article presents an analysis of the results of investigation of 54 children with ES admitted to the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology during the period 2012–2019. The male-to-female ratio was 1.07:1 and the median age of the disease onset was 4 years (0 months – 16 years). Based on the results of molecular genetic testing, the diagnosis was changed in three patients to congenital TTP. Thus, for further analysis 51 patients were available. Thirty-nine out of 51 children (76.5%) had secondary ES, the median age of the disease onset was 4 years (2 months – 12 years), the male-to-female ratio was 1.05:1. PID was genetically confimed in 25 out of 39 patients, in the remaining 14 cases the diagnosis of PID was based on clinical and laboratory fidings only. Twelve patients (22.2%) had idiopathic (primary) ES, the median age of the disease onset was 8 years (7 months – 16 years) and the male-to-female ratio was 1:1. The disease onset in ES was more often accompanied by isolated cytopenia: ITP – 22 (43.1%) patients, AIHA – 15 (29.4%) patients, immune neutropenia – 1 (2%) patient, simultaneously with AIHA and ITP – 8 (15.7%) patients, pancytopenia – 5 (9.8%) patients. The second cytopenia developed on average after 2 years (1 month – 9 years). Neutropenia was observed only in secondary ES. The mortality rate for ES was 9.8%. First-line therapy (IVIG, glucocorticoids) for ES showed low effctiveness and sustained remission was observed only in 5.9% of patients. Thirty-four (87%) patients with secondary ES and 9 (75%) patients with idiopathic ES required other lines of therapy. The next-line drugs that showed good effctiveness were rituximab (76.5%), MMF (94%), and sirolimus (83%). Combinations of rituximab and MMF, rituximab and sirolimus were also effctive and induced sustained remission without other therapy in 83.3% and 75% of patients respectively. Children with ES need thorough examination, including genetic testing, for the early diagnosis of PID and the exclusion of congenital TTP. The combination of rituximab and MMF proved to be the most effctive treatment for ES.
Non-spherocytic hemolytic anemia caused by erythrocyte pyruvate kinase defiiency: the analysis of genetic defects in pediatric patients, living in Russian Federation
Authors: Cherniak E. A. , Sokolova N. E. , Semiglazova K. V. , Lavrentyeva I. N. , Donush E. K. , Plaksina O. I. , Borisova M. V. , Danilyuk N. A. , Mitrofanova E. S. , Baturskaya I. P. , Revina N. G. , Burlutskaya T. I. , Rakov M. A. , Evstratov A. V. , Tselousova O. M. , Lebedev V. V. , Chaplygina N. V. , Koryakina I. V. , Osmulskaya N. S. , Afanasyeva E. I. , Nikonova O. E. , Sokolova L. I. , Tsedenisheeva E. Kh. , Yunusova I. M. , Zauralov E. O. , Osipova I. V. , Aslanyan K. S. , Sipacheva E. V. , Boldyreva O. P. , Kazaryan G. R. , Basharova E. V. , Mann S. G. , Kurnikova M. A. , Raikina E. V. , Smetanina N. S.
Published: May 2021

The article presents retrospective data analysis of a cohort of patients with PKD (n = 41 patients, aged 4 months – 26,5 years, median of age – 5 years 1 month) who were examined at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology for unspecifid hereditary hemolytic anemia during the period 2013–2020. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. In all patients, the diagnosis was confimed by Next Generation sequencing (NGS). The homozygous mutations in the PKLR gene were found in 10 patients (24.39%), compound heterozygous mutations in 31 patients (75.61%), 77.78% of them were missense mutations. Gender distribution (male:female) was 1:1.73. At least once transfusion of erythrocyte suspension was required to 40 (97.56%) patients. The minimum age at the time of the debut of transfusion dependence was the fist day of life, the maximum was 4 years. Exchange blood transfusion was performed in 13 children, severe normocytic hyperregenerative anemia with transfusion of red blood cells in the fist days of life was noted in 12 children, at the 1st month of life – in 9 children, at the 2nd month of life – in 8 children, at the 3rd month – in 6 children, at the 5th month – in 2 children, at the 1st year – in 1 child, and 2 children underwent single transfusions on the background of infectious episodes at 3 and 4 years respectively. Splenectomy due to high transfusion dependence was performed in 10 patients: transfusion independence was achieved in 5 patients, in 5 – an increase in the interval between blood transfusions. Median of surgical intervention (9 patients): 7 years 4 months, minimum age – 1 year 4 months, maximum – 14 years 4 months. In total, 36 genotypes were described in 41 patients, among them were: c.1529G>A in 3 patients, c.1137_1139del / c.1456C>T – in 2 patients, c.1079G>A/c.1529G>A in 2 patients, c.1130T>C/c.1456C>T in 2 patients, other genotypes occurred once. Two mutations were the most frequent: c.1456C>T (16.67%) and c.1529G>A (16.67%). 19 (46,34%) of patients had previously not described mutations.
Impact of Climate Change on Some Agricultural Crops Distribution and Productivity in Georgia
Authors: Megrelidze Lia , Kutaladze Nato , Gogichaishvili Gizo , Shvangiradze Marina
Published: May 2021

Under the increase of the concern for food security in the world, mainly caused by water resources shortages, the forecast and determination of crop yield at regional scale has been considered as a strategic topic. This study has been conducted to assess the possible impacts of the climate change on cereal crops productivity and irrigation requirement for two main producing regions of Georgia, according to the current crop pattern, and for the 2050s periods. With this aim, water-driven FAO-AquaCrop model has been used. Furthermore, ongoing and forecasted changes, up to the end of the century, in agro-climatic zones relevant for cereals production have been assessed. The climate change data was generated for RCP4.5 scenario through the global circulation model ECHAM4.1, dynamically downscaled on the region via regional climate model (RegCM4.1). Results show overall increase in cereal crop yields, but also enhancement in water shortages even considering optimum management practices under rainfed conditions. Based on the results obtained, recommendations have been developed for adaptation measures to the climate change for the Georgia Agriculture sector.
Estimating Rainfall Erosivity Factor Using Future Climate Projection in the Myjava Region (Slovakia)
Authors: Valent Peter , Výleta Roman
Published: May 2021

Rainfall erosivity factor (R) of the USLE model is one of the most popular indicators of areas potentially susceptible to soil erosion. Its value is influenced by the number and intensity of extreme rainfall events. Since the regional climate models expect that the intensity of heavy rainfall events will increase in the future, the currently used R-factor values are expected to change as well. This study investigates possible changes in the values of R-factor due to climate change in the Myjava region in Slovakia that is severely affected by soil erosion. Two rain gauge stations with high-resolution 1-minute data were used to build a multiple linear regression model (r
2 = 0.98) between monthly EI
30 values and other monthly rainfall characteristics derived from low-resolution daily data. The model was used to estimate at-site R-values in 13 additional rain gauge stations homogeneously dispersed over the whole region for four periods (1981–2010, 2011–2040, 2041–2070, 2071–2100). The at-site estimates were used to create R-factor maps using a geostatistical approach. The results showed that the mean R-factor values in the region might change from 429 to as much as 520 MJ.mm.ha−1.h−1.yr−1 in the second half of the 21st century representing a 20.5% increase.
About one method of calculation in the arbitrary curvilinear basis of the Laplace operator and curl from the vector function
Authors: Gladkov S. O.
Published: May 2021

A simple algorithm for calculating Christoffel symbols, a covariant projection of the result of the Laplace operator's action on the vector, vector curl and other similar operations in an arbitrary oblique base are proposed. For an arbitrary base with ortho ei
is found the expressions of vector projections (ΔA)
i
and (rot
A)
i
, where A is a counter variant vector. Examples of orthonormal bases are considered and general expressions for (ΔA)
i
and (rot
A)
i
for the bases are also given. As a demonstration of the working capacity of the common formulas obtained, detailed calculations of (ΔA)
i
and (rot
A)
i
as an example are made in cases of spherical and cylindrical coordinate systems.
A prediction model of urban counterterrorism based on stochastic strategy
Authors: Qi Xiangwei , Li Haifang , Chen Bingcai , Altenbek Gulila
Published: May 2021

With ever increasing complexity and intelligence of the modern cities, protecting key public facilities and important targets from any damage is a major challenge for the security sector. In all types of anti-terrorism prediction models, the prediction of attack behaviour is indispensable. Therefore, the attack behaviour model plays an important role in the anti-terrorism security system. This paper builds the attacker’s behaviour model, and carries out the prediction about the possible attack behaviour by the attacker model based on random strategy. According to the attack strategies, analysis and construction of the attack tree and attack graph are carried out based on the state-based stochastic model. The paper describes the security system in detail taking use of the state-based stochastic model method, so as to clarify the state distribution and the transfer relationship between the states of various security resources after threatened by attacks. At the same time, this paper applies the state-based stochastic model to establish the attacker model through the impact of attack on the security system.
Predicting stock high price using forecast error with recurrent neural network
Authors: Bao Zhiguo , Wei Qing , Zhou Tingyu , Jiang Xin , Watanabe Takahiro
Published: May 2021

Stock price forecasting is an eye-catching research topic. In previous works, many researchers used a single method or combination of methods to make predictions. However, accurately predicting stock prices is very difficult. To improve the predicting precision, in this study, an innovative prediction approach was proposed by recurrent substitution of forecast error into the historical neural network model through three steps. According to the historical data, the initial predicted value of the next day is obtained through the neural network. Then, the prediction error of the next day is obtained through the neural network according to the historical prediction error. Finally, the initial predicted value and the prediction error are added to obtain the final predicted value of the next day. We use recurrent neural network prediction methods, such as Long Short-Term Memory Network Model and Gated Recurrent Unit, which are popular in the recent neural network study. In the simulations, the past stock prices of China from June 2010 to August 2017 are used as training data, and those from September 2017 to April 2018 are used as test data. The experimental findings demonstrate that the proposed method with forecast error gives a more accurate prediction result for the stock’s high price on the next day, which indicates that the performance of the proposed one is superior to that of the traditional models without forecast error.
Research on the countermeasures of cultivating the competence of born after 2000 college student cadres
Authors: Pan Jingyu , Shu Zengxuan
Published: May 2021

With the passage of time, the ‘born after 2000’ student group has stepped into the university campus and gradually become the main force of the college student cadre team. It has brought many new challenges while playing a huge role. The ‘born after 2000’ student group has distinctive group characteristics under the brand of the times, such as strong self-consciousness, rich material conditions and diverse network behaviour. The management of the college student cadre team needs to make new changes based on the characteristics of the ‘born after 2000’ student group. Therefore, from the perspective of competence, this paper combines the characteristics of the ‘born after 2000’ student group with the competence training and carries out countermeasures research on the competence cultivation of ‘born after 2000’ college student cadres from the four aspects of selection and appointment, education and training, supervision and assessment, reward and incentive, to solve the practical problems in the cultivation of college student cadres under the new situation, and provides some reference for the future-related theoretical research and educational practice.
Walking model and planning algorithm of the over-obstacle pipe climbing robot
Authors: Liu Dengbiao , Li Cuiyun , Zhong Peisi
Published: May 2021

Effective inspection of pipelines is of significant importance in the industry. In order to reduce human labour, risk and expenses in this area, robots can be applied. The pipe robot should perform not only the linear motion in the axial direction but also the rotary motion in the circumferential direction while working. Meanwhile, in order to achieve reasonable performance and efficiency, these robots should have high enough normal linear motion velocity. They should be able to cross a pipe in one direction to another pipe in a different direction to achieve the over-obstacle function. In this study, a double-joint wheeled robot model is established to fulfil the actions of fast walking, rotation around the pipe and over-obstacle on spatial pipes. Based on the expected position on the pipe for the robot constructed by the proposed model, the precise starting position and control synthesis of the axial and circumferential velocities are initially determined. In order to study the velocity synthesis more accurately, the pipe is unfolded along the axial direction to transform the spatial motion into a plane motion. A novel spatial distribution form of driving wheels is proposed. In addition, based on the initial position of the straight, T-shaped, L-shaped, two-axis ‘+’-shaped and spatial three-axis ‘+’-shaped pipes, the posture adjustment of the robot prior, during and after the over-obstacle is investigated. Furthermore, the corresponding planning algorithms are established.
Modelling of Thin-Layer Drying of Osmo-Pretreated Red Bell Pepper
Authors: Odewole Michael Mayokun , Falua Kehinde James
Published: May 2021

The paper observes a thin-layer drying behaviour of red bell pepper. The red bell pepper (192 samples) was pretreated in osmotic solution of salt of concentrations 5–20% (w/w) at osmotic solution temperatures (30–60 °C) and osmotic process durations (30–120 min) and dried at 60 °C in a locally fabricated convective dryer after preformation of osmotic dehydration pretreatment process. Experimental moisture content values obtained from the drying process were converted to moisture ratios. Seven existing thin-layer drying model equations were used for model equation fitting. The predicted and experimental (observed) moisture ratios were analysed statistically. The statistical indices and rules used to judge and select the model equation that would best describe the process were the highest values of coefficient of determination (R
2); the lowest values of chi-square (χ2), root mean square error (RMSE), and sum of squares error (SSE). Results showed that the two-term exponential model equation best described the drying behaviour of osmo-pretreated red bell pepper. The ranges of statistical indices of selected two-term exponential model equation are: R
2 (0.9389–0.9751), χ2 (0.0642–0.1503), RMSE (0.2032–0.1668), and SSE (0.6424–1.5027).
Asymmetry models based on ordered score and separations of symmetry model for square contingency tables
Authors: Ando Shuji
Published: May 2021

This study proposes two original asymmetry models based on ordered scores for square contingency tables with the same row and column ordinal classifications. The proposed models can be applied to cases in which the scores of all categories are known or unknown. In the proposed models, the log odds for an observation falling in the (i, j)th cell instead of the (j, i)th cell are inversely proportional to the difference of the ordered scores corresponding to categories i and j. The asymmetry parameter of the proposed model can be useful for inferring whether the row variable is stochastically greater than the column variable or vice versa. The proposed models constantly hold when the symmetry model holds, but the converse is not necessarily true. This study also examines what is necessary for a model, in addition to the proposed models, to satisfy the symmetry model, and gives separations of the symmetry model using the proposed and marginal mean equality models. We apply real data to show the utility of the proposed models. The proposed models provide a better fit than that of the existing models.
Hang with Me—Exploring Fandom, Brandom, and the Experiences and Motivations for Value Co-Creation in a Music Fan Community
Authors: Edlom Jessica , Karlsson Jenny
Published: May 2021

Active and co-creative audiences are sought, used, tracked and taken for granted in the quest for strong music brands. Fan communities are co-opted to build value for brands and used to foster communication in transmedia marketing campaigns. However, when focusing on audiences and fans’ digital media activities, digital traces and numbers, important questions of motivations, expectations, experiences, morals and power structures are often overlooked. Drawing on a digital ethnographic study and an interdisciplinary perspective, we investigate a fan community of the Swedish artist Robyn, both online and offline. The article contributes to the concepts of fandom and brandom and the notion of value. It also adds to the knowledge about the perspective of fans and fans’ motivations for taking part and co-creating value in a highly commercialised and strategised music market.