bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of the transfer of the best european technologies to implement the system for forming of civil servant-leader
Authors: Podolchak Nazar , Tsygylyk Natalia , Khim Mariia
Published: September 2021

Public service is a means to ensure interaction between the state and society. The well-being of the population directly depends on its effective functioning. As you know, the effectiveness of solving the tasks set is 80 % ensured by its leaders – civil servants-leaders. It is they who are the engine of positive changes and the guarantor of the effectiveness of the activities of the entire team. Therefore, in order to bring the civil service to a qualitatively new level of efficiency, it is necessary to change the approach to the formation of soft-skills and hard-skills of employees-leaders. For this, it is necessary to introduce a comprehensive system for the development of the necessary skills. It is worth, firstly, to apply the transfer of the best European technologies. Secondly, to take into account the realities of the post-industrial society. Thirdly, to take into account the opinion of the public. An example of the application of an integrated approach to the formation of an employee-leader is given. For this, an analysis of the system of training and advanced training of civil servants in a developing country, the leading countries of the European Union, the Organization for Economic Cooperation and Development – Germany, France, as well as the nearest country with positive experience of joining the EU – Poland. The skills and activities that contribute to the formation of a civil servant-leader both from the point of view of citizens and taking into account the competencies necessary for effective work are highlighted. For this, the methods of electronic sociological survey of public opinion between the ages of 18 and 60 were used in a sample of 1000 people with an average statistical dispersion of residence throughout the state and an analysis of literary sources. A system for the formation of an effective civil servant-leader with the use of technology transfer has been developed for implementation.
Sign language dactyl recognition based on machine learning algorithms
Authors: Kenshimov Chingiz , Buribayev Zholdas , Amirgaliyev Yedilkhan , Ataniyazova Aisulyu , Aitimov Askhat
Published: September 2021

In the course of our research work, the American, Russian and Turkish sign languages were analyzed. The program of recognition of the Kazakh dactylic sign language with the use of machine learning methods is implemented. A dataset of 5000 images was formed for each gesture, gesture recognition algorithms were applied, such as Random Forest, Support Vector Machine, Extreme Gradient Boosting, while two data types were combined into one database, which caused a change in the architecture of the system as a whole. The quality of the algorithms was also evaluated.
The research work was carried out due to the fact that scientific work in the field of developing a system for recognizing the Kazakh language of sign dactyls is currently insufficient for a complete representation of the language. There are specific letters in the Kazakh language, because of the peculiarities of the spelling of the language, problems arise when developing recognition systems for the Kazakh sign language.
The results of the work showed that the Support Vector Machine and Extreme Gradient Boosting algorithms are superior in real-time performance, but the Random Forest algorithm has high recognition accuracy. As a result, the accuracy of the classification algorithms was 98.86 % for Random Forest, 98.68 % for Support Vector Machine and 98.54 % for Extreme Gradient Boosting. Also, the evaluation of the quality of the work of classical algorithms has high indicators.
The practical significance of this work lies in the fact that scientific research in the field of gesture recognition with the updated alphabet of the Kazakh language has not yet been conducted and the results of this work can be used by other researchers to conduct further research related to the recognition of the Kazakh dactyl sign language, as well as by researchers, engaged in the development of the international sign language
Development of green production technology and research of harpagophytum procumbens root dry extract
Authors: Kriukova Anna , Lytkin Dmytro , Marchenko Mykhailo , Vladymyrova Inna
Published: September 2021

The aim of this work is to study of standardization parameters and pharmacological properties of Harpagophytum procumbens (H. procumbens) root dry extract.

Materials and methods – obtaining of H. procumbens root dry extract was performed in accordance with developed scheme that is characterized by simplicity and cost-effectiveness of technology compared to analogous scheme. Study of standardization parameters of obtained extract was performed in accordance with the requirements of the monograph «Harpagophyti extractum siccum» of the State Pharmacopoeia of Ukraine 2.2., harmonized with the monograph «Harpagophyti extractum siccum» of the European Pharmacopoeia 9.5. Pharmacology study of analgesic and anti-inflammatory activities were conducted on the rat paw formalin-induced edema model.

Results. Obtained H. procumbens root dry extract is a free flowing, non-hygroscopic, light brown powder with taste and odor that is specific to raw material of H. procumbens. Determined loss on drying was 3.2±0.18 %. Content of heavy metals in dry extract was not more than 0.01 % (100 ppm). Harpagoside was identified by TLC method. Chromatographic zones on the obtained chromatograms of the reference solution and test solutions are the same in intensity of a color, cross-over and sharpness of development. Based on the results of the research performed by HPLC method, it has been established that content of harpagoside in investigated H. procumbens root dry extract is 2.50±0.02 %.

According to the results of pharmacological research it was found that investigated dry extract (the content of harpagoside is not less than 37.0 mg/kg) showed a higher activity compared to reference drug («Phong Te Thap»).

Conclusions. A new method of obtaining dry extract of H. procumbens (3.5:1) was proposed. The developed green production technology is simple; it does not require special equipment and expensive solvents. A correspondence of quality parameters with the requirements of State Pharmacopoeia of Ukraine and European Pharmacopoeia: appearance, identification of harpagoside and fructose, loss of drying, content of heavy metals, assay of harpagoside (2.50±0.02 %) was set. Analgesic and anti-inflammatory activities of H. procumbens dry extract has been established
Game Storytelling in the Formation Of Historical Memory: the Potential of New Media Formats
Authors:   St Petersburg University, Vyrovtseva E. V. , Simakova S. I. ,   Chelyabinsk State University
Published: September 2021

The paper is devoted to the study of the actual topic of the formation and development of communicative-cultural dialogue in the context of continuous segmentation of society. The latter was touched upon by f E. Toffler and it increases both the vertical (intergenerational) and horizontal (social) division. This problem is closely related to another topical issue — the formation of historical memory, without which it is impossible to imagine the unity of the country and public dialogue. The creators of modern multimedia projects have proposed a new communication format, a new way of talking about the past of the country and the world. Game storytelling can be safely called a new type of media text in demand. Research of the projects “1917. Free History” (https://project1917.ru/), “History Map” (https://kartaistorii.ru/), “1968Digital. The year when it all began” (https://1968.digital/ru/main) from the point of view of their genre and functional features, methods of organizing interactive communication and means of influencing the audience allows us to identify the features of their functioning inthe context of the stated problem.
Banco de Dados Espacial de Precipitação do Estado do Rio Grande do Sul
Authors: Brubacher João Paulo , Oliveira Guilherme Garcia de , Guasselli Laurindo Antonio
Published: September 2021

Resumo Atualmente, ao obter séries históricas de precipitação, é necessário realizar o preenchimento de falhas, interpolar e estimar a precipitação para área de interesse, principalmente em locais com baixa densidade de estações pluviométricas. Então, este estudo teve como objetivo gerar um banco de dados espacial com séries históricas de precipitação para o estado do Rio Grande do Sul, que permita a consulta a índices de precipitação por bacia, por município e por coordenadas geográficas, sem a necessidade de pós-processamento. A metodologia foi estruturada em cinco etapas: adquirir, organizar e preencher falhas das séries históricas de precipitação; interpolar, por meio do método Inverso da Potência da Distância (IPD), dados de chuva para uma malha regular com resolução espacial de 20 km; calcular índices de precipitação (Tempo de Retorno, Chuva Média Mensal e Anual, índice de Anomalia de Chuvas (IAC), Número de dias de Precipitação); codificar e dividir bacias hidrográficas a partir do Modelo Digital de Elevação (MDE); gerar banco de dados: organizar matrizes e tabelas para consultas. A validação cruzada da interpolação apresentou um EMA (Erro Médio Absoluto) que variou entre 1,02 e 3,20 mm, enquanto o EMQ (Erro Médio Quadrático) variou entre 6,4 e 8,4 mm. A disponibilização desse banco de dados na internet, com um arquivo de saída compatível com a maioria dos softwares de SIG, representa um ganho importante em pesquisas que necessitem utilizar longas séries temporais.
Performance of scores in the prediction of clinical outcomes in patients admitted from the emergency service
Authors: Silva Luana Matuella Figueira da , Diogo Luciano Passamini , Vieira Letícia Becker , Michielin Fabiano Da Costa , Santarem Michelle Dornelles , Machado Maria Luiza Paz
Published: September 2021

Objective: to evaluate the performance of the quickSOFA scores and Systemic Inflammatory Response Syndrome as predictors of clinical outcomes in patients admitted to an emergency service. Method: a retrospective cohort study, involving adult clinical patients admitted to the emergency service. Analysis of the ROC curve was performed to assess the prognostic indexes between scores and outcomes of interest. Multivariate analysis used Poisson regression with robust variance, evaluating the relationship between variables with biological plausibility and outcomes. Results: 122 patients were selected, 58.2% developed sepsis. Of these, 44.3% had quickSOFA ≥2 points, 87% developed sepsis, 55.6% septic shock and 38.9% died. In the evaluation of Systemic Inflammatory Response Syndrome, 78.5% obtained results >2 points; of these, 66.3% developed sepsis, 40% septic shock and 29.5% died. quickSOFA ≥2 showed greater specificity for diagnosis of sepsis in 86% of the cases, for septic shock 70% and for mortality 64%, whereas the second score showed better results for sensitivity with diagnosis of sepsis in 87.5%, septic shock in 92.7% and death in 90.3%. Conclusion: quickSOFA showed by its practicality that it can be used clinically within the emergency services, bringing clinical applicability from the risk classification of patients for the early recognition of unfavorable outcomes.
Content analysis of the Global Alliance for Nursing and Midwifery discussion forum: an online community of practice
Authors: Chu Hillary , Gresh Ashley , Bolanos Valentina , Reynolds Nancy
Published: September 2021

Objective: to examine the usage and content of the Global Alliance for Nursing and Midwifery (GANM) discussion forum in relation to nursing and midwifery education and practice. Method: a qualitative conventional content analysis was performed. Subject lines from 1689 discussion board threads were extracted and used as the unit of analysis. A-priori codes were developed based on topical relevance (e.g. maternal health) and typical discussion board usage (e.g. announcing educational opportunities). Emerging codes were further identified while coding the data (e.g. infectious diseases). Results: the GANM discussion forum was used most frequently for information exchange (43.8%), such as dissemination of new information on evidence-based practice, and to announce educational opportunities (24.8%). The most frequently discussed topics were nursing (14.2%; e.g. the role of nurses in primary care, nursing education, etc.) and maternal health (13.8%; e.g. postpartum care, maternal mortality, etc.). Infectious diseases were discussed in 9% of threads, 40% of which concerned the current coronavirus pandemic. Conclusion: findings reinforce the utility of the GANM as a platform for professional development and continuing education. As a platform for disseminating empirical research, the GANM can be leveraged to have an influence on real-world, evidence-based practice.
Decontamination of stainless-steel bowls with 80% (w/v) alcohol for 30 s and 60 s: randomized experimental study
Authors: Ramos Melissa Santiloni Montanha , Paniguel Patricia Leme , Sadatsune Terue , Graziano Kazuko Uchikawa , Mondelli Alessandro Lia , Bocchi Silvia Cristina Mangini
Published: September 2021

Objective: to compare the efficacy of 80% (w/v) alcohol, rubbed for 30 and 60 seconds, in the manual processing of stainless-steel wash bowls, after cleaning with running water and neutral detergent. Method: experimental study conducted in a hospital in the state of São Paulo, Brazil, on 50 bowls randomly divided into two groups of 25 bowls each for interventions of 30 and 60 seconds of rubbing with 80% (w/v) alcohol. Results: based on the microbiological analyses collected, before and after the interventions for both groups, partial efficacy of the disinfectant was observed even when extending rubbing time. In both groups, there was a higher prevalence of survival of Pseudomonas aeruginosa, with 14 strains that were resistant to carbapenems, being, specifically, 11 to imipenem and three to meropenem. Conclusion: stainless-steel bed wash bowls decontaminated for reuse by 80% (w/v) alcohol, after cleaning with running water and neutral detergent, showed to be reservoirs of hospital pathogens. The use of bed wash bowls for patients with intact skin would not have worrying consequences, but considering those with non-intact skin and the contamination of professionals’ hands, the results in this study justify the search for other decontamination methods or the adoption of disposable bed baths.
Isolation and screening of chromium resistant bacteria from industrial waste for bioremediation purposes
Authors: Kalsoom  , Batool Afshan , Din Ghufranud , Din Salah Ud , Jamil Johar , Hasan Fariha , Khan Samiullah , Badshah Malik , Shah Aamer Ali
Published: September 2021

Abstract Chromium (VI) a highly toxic metal, a major constituent of industrial waste. It is continuously release in soil and water, causes environmental and health related issues, which is increasing public concern in developing countries like Pakistan. The basic aim of this study was isolation and screening of chromium resistant bacteria from industrial waste collected from Korangi and Lyari, Karachi (24˚52ʹ46.0ʺN 66˚59ʹ25.7ʺE and 24˚48ʹ37.5ʺN 67˚06ʹ52.6ʺE). Among total of 53 isolated strains, seven bacterial strains were selected through selective enrichment and identified on the basis of morphological and biochemical characteristics. These strains were designated as S11, S13, S17, S18, S30, S35 and S48, resistance was determined against varying concentrations of chromium (100-1500 mg/l). Two bacterial strains S35 and S48 showed maximum resistance to chromium (1600 mg/l). Bacterial strains S35 and S48 were identified through 16S rRNA sequence and showed 99% similarity to Bacillus paranthracis and Bacillus paramycoides. Furthermore, growth condition including temperature and pH were optimized for both bacterial strains, showed maximum growth at temperature 30ºC and at optimum pH 7.5 and 6.5 respectively. It is concluded that indigenous bacterial strains isolated from metal contaminated industrial effluent use their innate ability to transform toxic heavy metals to less or nontoxic form and can offer an effective tool for monitoring heavy metal contamination in the environment.
Medium and large-sized mammals of a private protected wetland in the Cerrado-Amazon biological corridor, Brazil
Authors: Silva D. S. , Ribeiro M. V. , Soares F. H.
Published: September 2021

Abstract Brazil is the world's richest country in biodiversity, including mammal species. In the Brazilian Cerrado biome, mammalian diversity is vast, with about 251 species, 32 of them are endemic and 22 listed as threatened species. In this work, we investigated species diversity of medium- and large-sized mammals in the private protected area RPPN Pontal do Jaburu (RPPN-PJ) and its surroundings, which is a flooded area located in an important biological corridor in the Cerrado-Amazon ecotone zone, a priority area for biodiversity conservation in Brazil. We used camera-trapping, active search (night and day), and track survey during dry season (Apr – Aug 2016). We recorded 29 mammal species, being the Carnivora order the most representative with 11 species. Regarding threat status, 35.7% of the recorded species were listed as threatened in Brazil and 32.1% worldwide. We highlight the high relative frequency of threatened species records such as Tapirus terrestris, Panthera onca, Blastocerus dichotomus, Pteronura brasiliensis, Priodontes maximus, and other, as well as the presence of the newly described aquatic mammal species Inia araguaiaensis. We stress the importance of RPPN-PJ and its surroundings for mammal conservation, which include complex habitats (wetlands) located in an important ecotone zone.
Regulon: An overview of plant abiotic stress transcriptional regulatory system and role in transgenic plants
Authors: Warsi M. K. , Howladar S. M. , Alsharif M. A.
Published: September 2021

Abstract Population growth is increasing rapidly around the world, in these consequences we need to produce more foods to full fill the demand of increased population. The world is facing global warming due to urbanizations and industrialization and in this concerns plants exposed continuously to abiotic stresses which is a major cause of crop hammering every year. Abiotic stresses consist of Drought, Salt, Heat, Cold, Oxidative and Metal toxicity which damage the crop yield continuously. Drought and salinity stress severally affected in similar manner to plant and the leading cause of reduction in crop yield. Plants respond to various stimuli under abiotic or biotic stress condition and express certain genes either structural or regulatory genes which maintain the plant integrity. The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. These transcription factors are known as masters regulators because its single transcript regulate more than one gene, in this context the regulon word is fascinating more in compass of transcription factors. Progress has been made to better understand about effect of regulons (AREB/ABF, DREB, MYB, and NAC) under abiotic stresses and a number of regulons reported for stress responsive and used as a better transgenic tool of Arabidopsis and Rice.
Thalassemia, a human blood disorder
Authors: Shafique F. , Ali S. , Almansouri T. , Van Eeden F. , Shafi N. , Khalid M. , Khawaja S. , Andleeb S. , Hassan M. ul
Published: September 2021

Abstract A group of inherited blood defects is known as Thalassemia is among the world’s most prevalent hemoglobinopathies. Thalassemias are of two types such as Alpha and Beta Thalassemia. The cause of these defects is gene mutations leading to low levels and/or malfunctioning α and β globin proteins, respectively. In some cases, one of these proteins may be completely absent. α and β globin chains form a globin fold or pocket for heme (Fe++) attachment to carry oxygen. Genes for alpha and beta-globin proteins are present in the form of a cluster on chromosome 16 and 11, respectively. Different globin genes are used at different stages in the life course. During embryonic and fetal developmental stages, γ globin proteins partner with α globin and are later replaced by β globin protein. Globin chain imbalances result in hemolysis and impede erythropoiesis. Individuals showing mild symptoms include carriers of alpha thalassemia or the people bearing alpha or beta-thalassemia trait. Alpha thalassemia causes conditions like hemolytic anemia or fatal hydrops fetalis depending upon the severity of the disease. Beta thalassemia major results in hemolytic anemia, growth retardation, and skeletal aberrations in early childhood. Children affected by this disorder need regular blood transfusions throughout their lives. Patients that depend on blood transfusion usually develop iron overload that causes other complications in the body systems like renal or hepatic impairment therefore, thalassemias are now categorized as a syndrome. The only cure for Thalassemias would be a bone marrow transplant, or gene therapy with currently no significant success rate. A thorough understanding of the molecular basis of this syndrome may provide novel insights and ideas for its treatment, as scientists have still been unable to find a permanent cure for this deadly disease after more than 87 years since it is first described in 1925.
Do Dipteryx alata Vogel seedlings recover the quality and the photosynthetic and antioxidant responses in the post-flooding?
Authors: Linné J. A. , Jesus M. V. , Lima V. T. , Reis L. C. , Santos C. C. , Scalon S. P. Q. , Dresch D. M.
Published: September 2021

Abstract Dipteryx alata Vogel is a tree species widely found in Cerrado, settling preferentially in well drained soils. Studies related to ecophysiology of D. alata may contribute to the decision making about using seedlings of this species in projects aimed at the recovery of degraded areas where seasonal flooding happens. This study aimed to assess the effects of flooding on photosynthetic and antioxidant metabolism and quality of D. alata seedlings cultivated or not under flooding during four assessment periods (0, 20, 40, and 60 days), followed by 100 days after the end of each assessment period (0+100, 20+100, 40+100, and 60+100 days), allowing verifying the potential for post-flooding recovery. Flooded plants showed lower photosynthetic efficiency than non-flooded plants, regardless of the periods of exposure. However, this efficiency was recovered in the post-flooding, with values similar to that of the non-flooded seedlings. Moreover, the damage to FV/FM was evidenced by an increase in the period of exposure to flooding, but recovery was also observed at this stage of the photosynthetic metabolism. Seedling quality decreased under flooding, not varying between periods of exposure, but remained lower although the increase observed in the post-flooding period, with no recovery after flooding. The occurrence of hypertrophied lenticels associated with physiological changes and an efficient antioxidant enzyme system might have contributed to the survival and recovery of these seedlings. Thus, this species is sensitive to flooding stress but capable of adjusting and recovering metabolic characteristics at 100 days after the suspension of the water stress, but with no recovery in seedling quality. Thus, we suggested plasticity under the cultivation condition and determined that the time of 100 days is not enough for the complete resumption of growth.
Current understanding of an Emerging Coronavirus using in silico approach: Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2)
Authors: Khalid S. , Siddique R. , Shaheen S. , Shahid M. N. , Shamim Z. , Khan M. K. A. , Serçe Ç. Ulubaş
Published: September 2021

Abstract Novel coronavirus (nCoV) namely “SARS-CoV-2” is being found responsible for current PANDEMIC commenced from Wuhan (China) since December 2019 and has been described with epidemiological linkage to China in about 221 countries and territories until now. In this study we have characterized the genetic lineage of SARS-CoV-2 and report the recombination within the genus and subgenus of coronaviruses. Phylogenetic relationship of thirty nine coronaviruses belonging to its four genera and five subgenera was analyzed by using the Neighbor-joining method using MEGA 6.0. Phylogenetic trees of full length genome, various proteins (spike, envelope, membrane and nucleocapsid) nucleotide sequences were constructed separately. Putative recombination was probed via RDP4. Our analysis describes that the “SARS-CoV-2” although shows great similarity to Bat-SARS-CoVs sequences through whole genome (giving sequence similarity 89%), exhibits conflicting grouping with the Bat-SARS-like coronavirus sequences (MG772933 and MG772934). Furthermore, seven recombination events were observed in SARS-CoV-2 (NC_045512) by RDP4. But not a single recombination event fulfills the high level of certainty. Recombination mostly housed in spike protein genes than rest of the genome indicating breakpoint cluster arises beyond the 95% and 99% breakpoint density intervals. Genetic similarity levels observed among “SARS-CoV-2” and Bat-SARS-CoVs advocated that the latter did not exhibit the specific variant that cause outbreak in humans, proposing a suggestion that “SARS-CoV-2” has originated possibly from bats. These genomic features and their probable association with virus characteristics along with virulence in humans require further consideration.
The impact of cow dung augmentation on soil restoration and bio-accumulation of metals (Lead and Cadmium) in Pheretima posthuma (Annelida: Clitellata)
Authors: Hussain M. , Liaqat I. , Bukhari S. M. , Khan F. S. , Adalat R. , Shafique M. Salman , Azam S. M. , Ali A. , Khalid M. , Shahid Z. , Iqbal M. Javed , Slahuddin  , Ehsan A.
Published: September 2021

Abstract To investigate the role of cow dung in soil reclamation and bio assimilation along with bio accumulation of heavy metals in earthworm (P. posthuma) (N=900) earthworms were used and treatment groups of CD-soil mixture of different proportion of cow dung were designed. Nonlethal doses of lead acetate and cadmium chloride were added in treatment groups. Mature P. posthuma were released in each experimental pot maintaining the favorable conditions. The pH, carbon, nitrogen, phosphorus, exchangeable cations, and heavy metal level of each mixture was evaluated. The results indicated that bio-assimilation of Pb and Cd by P. posthuma were significantly (P ˂ 0.01) higher in different soil-CD treatments compared to control. Highest bio-assimilation of both metals was observed in T1 of both groups (Pb = 563.8 mg/kg and Cd = 42.95 mg/kg). The contents of both metals were significantly (P ˂ 0.05) lowered in casting. The nutrient concentration in the final castings of all soil-CD treatments were also equally transformed from less or insoluble to more soluble and available for plants, except for carbon level which increased with CD proportion. It is concluded that cow dung as organic matter has a positive effect on soil reclamation and bio-assimilation of metals by P. posthuma.
A threefold approach including quantum chemical, molecular docking and molecular dynamic studies to explore the natural compounds from Centaurea jacea as the potential inhibitors for COVID-19
Authors: Muhammad S. , Maqbool M. F. , Al-Sehemi A. G. , Iqbal A. , Khan M. , Ullah S. , Khan M. T.
Published: September 2021

Abstract In the current report, we studied the possible inhibitors of COVID-19 from bioactive constituents of Centaurea jacea using a threefold approach consisting of quantum chemical, molecular docking and molecular dynamic techniques. Centaurea jacea is a perennial herb often used in folk medicines of dermatological complaints and fever. Moreover, anticancer, antioxidant, antibacterial and antiviral properties of its bioactive compounds are also reported. The Mpro (Main proteases) was docked with different compounds of Centaurea jacea through molecular docking. All the studied compounds including apigenin, axillarin, Centaureidin, Cirsiliol, Eupatorin and Isokaempferide, show suitable binding affinities to the binding site of SARS-CoV-2 main protease with their binding energies -6.7 kcal/mol, -7.4 kcal/mol, -7.0 kcal/mol, -5.8 kcal/mol, -6.2 kcal/mol and -6.8 kcal/mol, respectively. Among all studied compounds, axillarin was found to have maximum inhibitor efficiency followed by Centaureidin, Isokaempferide, Apigenin, Eupatorin and Cirsiliol. Our results suggested that axillarin binds with the most crucial catalytic residues CYS145 and HIS41 of the Mpro, moreover axillarin shows 5 hydrogen bond interactions and 5 hydrophobic interactions with various residues of Mpro. Furthermore, the molecular dynamic calculations over 60 ns (6×106 femtosecond) time scale also shown significant insights into the binding effects of axillarin with Mpro of SARS-CoV-2 by imitating protein like aqueous environment. From molecular dynamic calculations, the RMSD and RMSF computations indicate the stability and dynamics of the best docked complex in aqueous environment. The ADME properties and toxicity prediction analysis of axillarin also recommended it as safe drug candidate. Further, in vivo and in vitro investigations are essential to ensure the anti SARS-CoV-2 activity of all bioactive compounds particularly axillarin to encourage preventive use of Centaurea jacea against COVID-19 infections.
La construcción intelectual del concepto de colonialismo interno en América Latina: diálogos entre Cardoso de Oliveira, González Casanova y Stavenhagen (1959-1965)
Authors: Bringel Breno , Leone Miguel
Published: September 2021

Resumen Este artículo argumenta que el debate sobre el colonialismo interno en América Latina es resultado de una dinámica colectiva, transnacional e interdisciplinaria generada a partir de intercambios ocurridos en la confluencia entre la institucionalización de las ciencias sociales de la región y las críticas iniciales al horizonte modernizador imperante. Se reconstruye, a partir de diversas fuentes primarias originales, los diálogos seminales establecidos entre Roberto Cardoso de Oliveira, Pablo González Casanova y Rodolfo Stavenhagen entre finales de 1950 y la primera mitad de 1960 en torno al Centro Latinoamericano de Pesquisas en Ciencias Sociales - CLAPCS. Se propone así una genealogía y un itinerario del concepto de colonialismo interno en el que interactúan contexto, historia y teoría, en una trama de emergencia, construcción y reelaboración de una noción clave para el pensamiento latinoamericano, en sus contactos con otras afines como la de “fricción interétnica”.
Digestive disorders associated with the consumption of palm fiber (Elaeis guineensis) in feedlot cattle
Authors: Sarmento Natalia Maxine F.P. , Moura Márcio Alan O. , Cardoso Rosekelly J. , Lima Adrielli Heloise A. , Bezerra Junior Pedro S. , Duarte Marcos D. , Cerqueira Valíria D. , Riet-Correa Gabriela
Published: September 2021

ABSTRACT: Digestive disorders in cattle are associated with the breeding system and feed provided to the animals. Abomasal compaction is primarily related to the ingestion of forage with elevated levels of lignin, low quality, and difficult digestibility. In addition, the excess of fibrous food in the diet can lead to phytobezoars that may be responsible for intestinal obstruction disorders. This study aimed to describe pathological and clinical aspects of an outbreak of digestive disorders associated with the consumption of palm fiber (Elaeis guineensis). The outbreak struck a herd of 499 animals raised in a feedlot system after a change in diet that included an increase in the amount of palm fiber. Forty (8.01%) animals showed clinical signs such as fattening and regurgitation during rumination, and 21 (4.2%) animals died later. The cattle affected presented with apathy, emaciation, dehydration, distended abdomen, incomplete or absent ruminal movements, and congestive mucosa. Three animals were submitted to necropsy, and distended rumen and reticulum has a large amount of brownish liquid, long and tangled vegetable fibers with sand and stones. In two animals, the omasum had many rounded structures measuring approximately 5cm in diameter, made of vegetable fiber (phytobezoars). Abomasum of animals had similar material to the rumen, and one animal had compressed content. In two animals, dilatation was observed in the small intestine, and in the opening, the total obstruction of the lumen by phytobezoar was observed. During the follow-up of the slaughter of 76 cattle, 15 (19.7%) had phytobezoars of different sizes in the omasum and abomasum. The increased amount of oil palm fiber in animal feeding favored the occurrence of compression abomasum and intestinal obstruction phytobezoa, causing significant economic losses.
Perfil socioeconômico do produtor de flores e plantas ornamentais do Distrito Federal
Authors: Vidal Alda Mieko Rocha Kimura , Araújo Juliana Baldan Costa Neves , Gaspar Ricardo de Oliveira , Joaquim Maísa Santos , Souza Álvaro Nogueira de
Published: September 2021

Resumo: O agronegócio de flores e plantas ornamentais está se consolidando no Brasil. O perfil do produtor brasileiro é de pequeno porte e caracterizado como agricultura familiar. A produção de flores e plantas ornamentais tem um papel importante na economia, gerando empregos e distribuindo melhor a renda. No Distrito Federal a produção de floricultura é realizada pelo pequeno produtor e por sua família, tornando-a assim agricultura familiar. Esta pesquisa tem caráter exploratório e descritivo e foi realizada com o auxílio de um questionário misto para descrever e avaliar o perfil socioeconômico do produtor de flores e plantas ornamentais do Distrito Federal. A análise dos dados foi realizada pela análise estatística bidimensional para testar e validar os resultados obtidos. Os resultados em relação ao sexo dos produtores de flores e plantas ornamentais foram: homens (24,34%) com pelo menos 2 membros da família (16,98%), e para a produção de mudas, as mulheres (16,98%), com mais de 2 membros da família (13,21%). O estado civil dos produtores de flores divide-se em casados (58,82%) e solteiros (23,33%). Concluiu-se que o perfil socioeconômico do produtor de flores e plantas ornamentais é de caráter misto, agricultura familiar, sinais de amadorismo e não possui renda exclusivamente advinda da produção.
Os condicionantes institucionais e sociais do recrutamento da elite política do cooperativismo agroindustrial
Authors: Costa Paulo Roberto Neves , Stöberl Paulo Roberto
Published: September 2021

Resumo: Este artigo analisa o processo de recrutamento dos dirigentes da entidade de representação política do cooperativismo empresarial, os quais compõem o que chamamos de elite cooperativista. O objeto é o Sindicato e Organização das Cooperativas do Estado do Paraná (OCEPAR) nas duas últimas décadas. A pesquisa considerou, de um lado, os condicionantes institucionais, externos e internos a esta entidade e, de outro, os aspectos sociais dos membros desta elite. Além da produção de categorias analíticas que deem conta das particularidades desta elite, foram utilizados a legislação brasileira relativa ao cooperativismo, dados econômicos, documentos da OCEPAR e de outras entidades do cooperativismo e entrevistas. Constatamos que os aspectos institucionais do cooperativismo empresarial e as características sociais dos dirigentes desta entidade ajudam a explicar o fato de os presidentes das maiores cooperativas agroindustriais ocuparem de forma majoritária a diretoria da OCEPAR e, assim, se constituírem enquanto um canal de poder político entre tais cooperativas e a entidade, e desta com as autoridades e instituições políticas. Portanto, verificamos que alguns aspectos institucionais e sociais impactam fortemente o recrutamento desta elite cooperativista e, assim, a constituição do cooperativismo agroindustrial enquanto ator político, dimensão de grande relevância para tratarmos da sua importância econômica.
Competitiveness drivers for soybean exportation and the fundamental role of the supply chain
Authors: Filassi Monique , de Oliveira Andréa Leda Ramos
Published: September 2021

Abstract: Brazil is the world’s second-largest producer of soybeans and the largest exporter. Despite the growing importance in the international market in the last harvests, activities related to this product threaten this position. Due to its economic importance for the country, this study aims to identify the competitiveness drivers of soybean destined for the international market and to measure their impacts on the export process. Therefore, the used methodology considers the systemic character of different factors that affect the supply chain positively or negatively. As a result, the logistics infrastructure dimension was the only competitiveness driver classified as unfavorable among the analyzed factors. The advances in agribusiness are being subsequently followed by some sectors of the economy such as science and technology. On the other hand, the logistics sector has not been showing the same development, causing some weaknesses to persist, either due to the lack of infrastructure of transport production, or the inability to properly store the national harvest. The current challenge for the State is to ensure the maintenance of the quality of the infrastructure already installed and to promote an environment capable of attracting private capital and a new investment cycle.
¿Qué tipos de métodos de extensión prefieren y usan los extensionistas rurales? Comparación internacional y construcción de una tipología de acuerdo a sus métodos
Authors: Landini Fernando Pablo , Gallardo-López Felipe
Published: September 2021

Resumen: En contraste con el amplio corpus de literatura orientado a discutir diferentes enfoques o filosofías de extensión, existe un limitado interés por analizar los métodos de extensión rural. Este estudio cuantitativo analiza los tipos de métodos que prefieren y usan extensionistas rurales de nueve países, y explora la relación entre tipos de métodos y características sociodemográficas de los extensionistas. En general, los extensionistas prefieren y utilizan más métodos grupales, seguidos de individuales. Los métodos de articulación institucional y de comunicación de masas quedaron ubicados en tercer y cuarto lugar respectivamente, tanto a nivel de preferencias como de uso. Se observó un desajuste importante entre los métodos preferidos y los más utilizados. Se identificaron tres tipos de extensionistas de acuerdo a los métodos que prefieren y utilizan, uno centrado en el trabajo individual y grupal con productores y otros dos que priorizan o relegan métodos individuales o grupales (según el caso), complementándolos con acciones de articulación institucional.
Risco da base e sua volatilidade no comércio de soja em Mato Grosso (2009 a 2019)
Authors: Nardino Felipe Parmeggiani , Figueiredo Adriano Marcos Rodrigues
Published: September 2021

Resumo: Esta pesquisa analisa a volatilidade da base em hedges de soja nos municípios de Mato Grosso (Sorriso, Sapezal, Rondonópolis, Nova Mutum e Querência) com os preços futuros dos contratos com vencimento em janeiro, março e maio comercializados em Chicago, no período de 2009 a 2019. A abordagem teórica análoga à teoria de estocagem avaliou o comportamento da base e as diferenças entre as bases no plantio e na maturação dos futuros, visando identificar a existência de padrões de ganhos ou perdas de base, bem como os períodos que os otimizam. A teoria de convergência entre preços futuros e à vista na maturidade do contrato não se confirmou; em geral, existem perdas de base e a base não permanece em seus valores históricos, conforme apontado em literaturas norte-americanas para a soja. Para contratos com vencimento em janeiro e março, quanto mais próximo do vencimento do contrato, maior a perda oriunda do diferencial de bases, diferentemente do contrato de maio.
Mídia audiovisual no interior do Brasil e produção local de informação
Authors: Moreira Sonia Virgínia , Del Bianco Nélia Rodrigues , Martins Cézar Franco dos Santos
Published: September 2021

Resumo Este artigo se propõe a verificar a existência ou inexistência de produção local de conteúdo informativo em emissoras de rádio e em retransmissoras de rádio e TV no universo dos 32 municípios brasileiros de IDHM Muito Baixo localizados nas regiões Norte e Nordeste. A abordagem desses municípios emprega conceitos de mídia local e de jornalismo de proximidade para fundamentar a análise dos meios nas localidades. Os arranjos territoriais de mídia e de produção de informação em emissoras e retransmissoras locais são os objetos pesquisados. A consulta a textos legais e a observação empírica do conteúdo (re)produzido por emissoras de rádio nos municípios estudados sugerem que há um direcionamento, natural ou intencional, na implantação de sistemas de reprodução da informação originada de cidades médias ou centros urbanos. Os conceitos usados são: territórios, mídia local e “desertos de notícias”.
Reliability of information available on popular websites about vaccination of pregnant women
Authors: Pereira Carolina Guedes , Santos Raquel Freire , Faria Ana Paula Vieira , Silva Thales Philipe Rodrigues da , Pena Érica Dumont , Matozinhos Fernanda Penido
Published: September 2021

ABSTRACT Objective: To analyze the reliability of information available on popular websites about vaccination of pregnant women according to the recommendations of the Brazilian Ministry of Health. Method: Descriptive and comparative study. For data collection, a checklist composed of information on recommended, contraindicated, and indicated vaccines in special situations during pregnancy, according to the Ministry of Health, was elaborated. Results: None of the analyzed websites presented all the recommended information. Contraindications, most common adverse events, simultaneous administration of vaccines, information on the DT vaccine, and recommended vaccines in special situations were presented by a minority of websites. Conclusion: Information available on websites about the vaccination of pregnant women is not always based on the recommendations and misinformation may interfere with the acceptance of this practice. The importance of the professionals of the multidisciplinary team as information mediators, particularly the nurse, is emphasized, as is the need for regulating the production and dissemination of information on the internet.
CARE TRANSTION IN HOSPITAL DISCHARGE FOR ADULT PATIENTS: INTEGRATIVE LITERATURE REVIEW
Authors: Gheno Jociele , Weis Alísia Helena
Published: September 2021

ABSTRACT Objective: to summarize and analyze the scientific production on care transition in the hospital discharge of adult patients. Method: integrative review, conducted from May to July 2020, in four relevant databases in the health area: Public Medline (PubMed); Scientific Electronic Library Online (SciELO); Scopus and Virtual Health Library (VHL). The analysis of the results occurred descriptively and was organized into thematic categories that emerged according to the similarity of the contents extracted from the articles. Results: 46 articles from national and international journals, with a predominance of descriptive/non-experimental studies or qualitative studies, met the inclusion criteria. Five categories were identified: discharge and post-discharge process; Continuity of post-discharge care; Benefits of care transition; Role of nurses in care transition and Experiences of patients on care transition. Hospital discharge and care transitions are interconnected processes as transitions qualify the dehospitalization process. Different strategies for continuity of care should be adopted, as they offer greater safety to the patient. Studies have shown that nurses play a fundamental role in transitions and, in Brazil, this activity still needs to gain more space. Reduced hospitalizations, mortality, hospital costs and patient satisfaction are benefits of transitions. Conclusion: care transition is an effective strategy for the care provided to the patient being discharged. It points out the need for integration between the care network and assists services in decision-making about the continuity of care on discharge.
Ora-pro-nobis (Pereskia aculeata Miller): a potential alternative for iron supplementation and phytochemical compounds
Authors: Maciel Vinicius Borges Vieira , Bezerra Renata Queiroz , Chagas Eduardo Galvão Leite das , Yoshida Cristiana Maria Pedroso , Carvalho Rosemary Aparecida de
Published: September 2021

Abstract Ora-pro-nobis (OPN) (Pereskia aculeata Miller) is a non-conventional edible plant rich in protein, fibres and minerals. The innovation of this work is based on the sustainability production of the aqueous extract (green solvent) containing iron and bioactive compounds as well as employing a native plant from Brazil. A screening of phytochemicals components, phenolic compounds, flavonoids and tannins contents were performed using OPN extract. The antioxidant activity of the OPN aqueous extract was determined by three different assays as following: 2,2-diphenyl-1-picrylhydrazyl (DPPH•); Ferric Reducing Antioxidant Power (FRAP); and Oxygen Radical Absorbance Capacity (ORAC). The OPN dried leaves presented high protein and minerals contents. Indeed, the Fourier-Transform Infrared Spectroscopy (FTIR Spectroscopy) analysis performed in OPN aqueous extract confirmed the appearance of representative functional groups of the bioactive compounds. Overall the results suggested that it is possible to use simple aqueous solvent to produce OPN extract rich in iron, bioactive compounds and within antioxidant activity that could be potentially used as functional food ingredient.
Advances in yeast autolysis technology - a faster and safer new bioprocess
Authors: Alves Edson Marcelino , Souza Joyce Faria de , Oliva Neto Pedro de
Published: September 2021

Abstract The yeast autolysis process - an endogenous and irreversible lytic event, which occurs in cells caused by the action of intracellular enzymes, proteases and carbohydrases - is a well-known and an economic process, however, there is a constant risk of serious microbial contamination since there are many nutrients in the broth and this process is slow, favoring the growing of pathogens. The present work comes up with an attempt to accelerate the autolysis of Saccharomyces cerevisiae with focus on the high yield of yeast extract production through a fast, economic and simple technology. The proposed strategy is based on decreasing the pH of the yeast suspension at the beginning of autolysis through an acid shock to activate the cell autolytic system under stressful conditions of temperature and pH. The influence of cell concentration, temperature, time and acid shock at the beginning of the autolysis on yeast extract yields were studied. The best yields of proteins and total solids were observed for autolysis treated with acid shock (H2SO4 10 µL/g of dried yeast and final pH 4.4) at 60 °C (36, 84% of protein and 48, 47% of total solids extracted) and gradual increase of temperature 45 to 60 °C (41.20% of protein and 58.48% of total solids extracted). The shock could increase the speed of the process since the control reached about 30% of extract at 60 °C and the same experiment, however, with acid shock reached more than 43% in 12 h. When considering time in an industrial scale, it could be noted that the time was very important for the productivity as well as avoiding risk of pathogen contamination in autolysis. These results were very relevant for industrial purposes in the production of yeast extract, autolyzed yeast and glucan and mannan.