bluuebunny/crossref_metadata_2025 huggingface dataset:
Triglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study
Authors: Hoshino Takao , Mizuno Takafumi , Ishizuka Kentaro , Takahashi Shuntaro , Arai Satoko , Toi Sono , Kitagawa Kazuo
Published: October 2022

Background:Triglyceride-glucose (TyG) index has been proposed as a simple and creditable surrogate for insulin resistance and an independent predictor of cardiovascular outcomes. Due to lack of data on TyG index in stroke, we aimed to evaluate the predictive value of the index for recurrent vascular event risk among stroke patients.
Methods:This was a prospective observational study, in which 866 patients (mean age, 70.1 years; male, 60.9%) with ischemic stroke (n=781) or transient ischemic attack (n=85) within 1 week of onset were consecutively enrolled and followed up for 1 year. The TyG index was calculated as ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Patients were divided into 3 groups according to the tertile of TyG index levels: tertile 1, <8.48; tertile 2, 8.48–9.01; and tertile 3, >9.01. The primary outcome was a composite of major adverse cardiovascular events (MACE), including nonfatal stroke, nonfatal acute coronary syndrome, and vascular death.
Results: The median TyG index was 8.74 (interquartile range, 8.34–9.16). Higher levels of TyG index were significantly associated with increased prevalence of ipsilateral extracranial carotid (P=0.032) and intracranial (P=0.003) atherosclerotic stenosis. There were significant differences in the MACE risk between the three groups (annual rate, 8.6%, 11.6%, and 17.3% in the tertile 1, tertile 2, tertile 3 groups, respectively; log-rank P=0.005). After multivariable adjustments, the TyG index remains to be a significant predictor of MACE, with an adjusted hazard ratio for tertile 3 versus tertile 1 groups (95% confidence interval) of 2.01 (1.16–3.47). Similar results were also found for the risk of recurrent stroke.
Conclusions: TyG index is associated with cervicocerebral atherosclerosis and the MACE risk after a stroke, suggesting the potential value of TyG index to optimize the risk stratification of stroke patients.
Trial registration:URL: https://upload.umin.ac.jp. Unique identifier: UMIN000031913.
Antibacterial and cytotoxic efficacy of Nano- Hydroxyapatite Synthesized from Eggshell and Sheep bones bio Waste
Authors: Mousavi Seyyed Mojtaba , Hashemi Seyyed Alireza , Yousefi khadijeh , Rao Neralla Vijayakameswara , Omidifar Navid , Gholami Ahmad , Ghahramani Yasmin , Chiang Wei-Hung , nezhad Fatemeh Fallahi , Kalashgrani Masoomeh Yari
Published: October 2022

Background:Through a new material pattern addition approach, NHA is synthesized using eggshell materials and sheep bone under different calcination temperatures (respectively at 900 ° C and 800 ° C) using a sol-gel approach. NHA/Es and NHA/Sb, due to their biocompatibility and bioactivity, are widely used in applications such as antibacterial and cytotoxic of PDL cells and teeth and as hard tissue.
Results: We investigated the physicochemical properties of NHA/Es and NHA/Sb by performing FTIR, energy scattering X-ray analysis, SEM, and XRD. The formation of NHA / Es, NHA / Sb particles occurs due to the usage of Eggshell materials and sheep bones as a pattern in NHA synthesis, which are less crystalline. Results of surface morphology analysis of NHA particles indicate that these particles are discrete and rod-shaped at low temperatures (850 °C), whereas larger particles are formed at higher temperatures. Therefore, antibacterial activity against four gram-negative bacteria were investigated through MIC and MBC methods, which included E. coli, Pseudomonas aeruginosa, Candida, Saccharomyces and gram-positive bacteria including Staphylococcus aureus and Enterococcus faecalis.
Conclusions:The reason for the compatibility of calcined NHA / Sb powder as a substance used in biomedical applications is that this powder has shown strong antibacterial efficacy against all bacterial strains with a range of inhibitory zones. The nature and structure of PDLs have been studied in many studies; While we focus on the quantitative analysis of the structural properties of PDL cells and their cytotoxic activity through the use of bio waste materials.
Identification of Cuproptosis-Related Gene in Sepsis by Machine-Learning
Authors: Xie Junjie , Xue Lijun
Published: October 2022

Sepsis is a serious public issue that affects millions of people. Cuproptosis, a newly form of cell death, has been linked to the course of certain illnesses. Therefore, the goal of our study was to investigate clusters of sepsis associated with cuproptosis and to develop a prediction model. Using GSE33341 dataset, the expression profiles of immune- and cuproptosis-related genes (CRGs) in sepsis patients were examined. We investigated molecular clusters based on CRGs and the accompanying immune cell infiltration. The weighted gene co-expression network analysis (WGCNA) method was used to identify differentially expressed genes in a specific cluster. Four machine learning methods were then contrasted in order to determine the best machine model. A nomogram, calibration curve, decision curve analysis were used to validate predictive efficiency. Immune infiltration analysis revealed significant immunological heterogeneity among the CRGs. The random forest machine model indicated the best discriminative performance, with comparatively smaller residual and root mean square errors and a larger area under the curve (AUC = 0.983). A final 5-gene random forest model was created, and two external validation datasets demonstrated that it performed satisfactorily (AUC = 0.964 and 0.851). The accuracy of predicting sepsis was also demonstrated by the nomogram, calibration curve, and decision curve analysis. Further investigation indicated a substantial relationship between age and SAR1B expression. This study identified the impact of cuproptosis on sepsis for the first time, and further characterized the underlying molecular pathways causing sepsis heterogeneity.
Zika Virus triggers autophagy to exploit host lipid metabolism and drive viral replication
Authors: Stoyanova Gloria , Jabeen Sidra , Vinueza Joselyn Landazuri , Roy Sounak Ghosh , Lockshin Richard , Zakeri Zahra
Published: October 2022

Background: Zika Virus (ZIKV), an arbovirus of global concern, has been associated with neurological complications including microcephaly in newborns and Guillain-Barré Syndrome in adults. Like other flaviviruses, ZIKV depends on cholesterol to facilitate its replication; thus, cholesterol has been proposed as a therapeutic target to treat the infection using FDA-approved statins. Cholesterol is stored in intracellular lipid droplets (LD) in the form of cholesterol esters and can be regulated by autophagy. We hypothesize that the virus hijacks autophagy machinery as an early step to increase the formation of LD and viral replication, and that interference with this pathway will limit reproduction of virus.
Methods: We pretreated MDCK cells with atorvastatin or other inhibitors of autophagy prior to infection with ZIKV. We measured viral expression by qPCR for NS1 RNA and immunofluorescence for Zika E protein.
Results: Autophagy increases in virus-infected cells as early as 6 hours post infection (hpi). In the presence of atorvastatin, LD are decreased, and cholesterol is reduced, targeting key steps in viral replication, resulting in suppression of replication of ZIKV is suppressed. Other both early- and late-acting autophagy inhibitors decrease both the number of LD and viral replication. Bafilomycin renders cholesterol is inaccessible to ZIKV. We also confirm previous reports of a bystander effect, in which neighboring uninfected cells have higher LD counts compared to infected cells.
Conclusions: We conclude that atorvastatin and inhibitors of autophagy lead to lower availability of LD, decreasing viral replication. We conclude that bafilomycin A1 inhibits viral expression by blocking cholesterol esterification to form LD.
Posterior inference on Quanto option pricing model with liquidity-adjustment
Authors: Gao Rui , Bai Yanfei
Published: October 2022

This paper proposes an alternative approach to estimate parameters and evaluate the quanto option with stock liquidity under Bayesian framework. First, we derive an explicit expression of the quanto option price with liquidity-adjustment in an alternative way. Then, an applicable likelihood is proposed to conduct posterior inference on model parameters based on the joint distribution of underlying stock price dynamics and the exchange rate process, which provides a new perspective to estimate the correlation coefficient. Moreover, the statistical inference on the quanto option price is conducted by the posterior distribution and numerical algorithm. The proposed method considers the impact of parameter uncertainty on option prices, particularly the correlation coefficient randomness. Finally, the numerical analysis is performed for examining the effectiveness of the proposed method in terms of estimating parameters and pricing quanto options. Empirical results indicate that the proposed method is feasible in pricing and predicting quanto option with liquidity-adjustment.
A family study and literature review of ELOVL4-associated spinocerebellar ataxia type 34
Authors: Nishide Masahiro , Marquand Kathleen Le , Davis Mark , Halmágyi Gábor M. , Fellner Avi , Narayanan Ramesh K. , Kennerson Marina L. , Reddel Stephen W. , Worgan Lisa , Kumar Kishore R.
Published: October 2022

Autosomal dominant disease-causing variants in the ELOVL4 gene (Elongation of Very Long Chain Fatty Acids-like 4) cause spinocerebellar ataxia type 34 (SCA34; ATX-ELOVL4), classically associated with a skin condition known as erythrokeratoderma. Here, we report a large Italian-Australian family with spinocerebellar ataxia. Notably, while there were dermatological manifestations (eczema), erythrokeratoderma was not present. Using a next generation sequencing panel, we identified a previously reported ELOVL4 variant, NM_022726.4: c.698C>T (p.Thr233Met). The variant was initially classified as a variant of uncertain significance, however, through segregation studies, we reclassified the variant as likely pathogenic. We subsequently performed the first dedicated literature review of ELOVL4 variants causing ataxia to gain further insights into genotype-phenotype relationships. We identified a total 59 reported cases of SCA34 to date. The majority had gait ataxia (88.1%), limb ataxia (76.3%), dysarthria (62.7%), and nystagmus (57.6%). Of note, skin lesions related to erythrokeratoderma were seen in a minority of cases (33.9%). Other extracerebellar manifestations included pyramidal tract signs, autonomic disturbances, retinitis pigmentosa and cognitive impairment. For brain MRI data, cerebellar atrophy was seen in all cases (100%), whereas the hot cross bun sign (typically associated with multiple-system atrophy type C) was seen in 30.3% of cases. Our family study and literature review highlight the variable phenotypic spectrum of SCA34. Importantly, it shows that erythrokeratoderma is not found in most cases and that, while a dermatological assessment may be helpful in these patients, SCA34 diagnosis should be considered irrespective of dermatological manifestations.
Primary ovarian insufficiency associated with lenvatinib therapy in a patient with hepatocellular carcinoma
Authors: Aoki Yoichi , Inoue Yosuke , Sasahira Naoki , Ono Makiko , Inamura Kentaro , Kataoka Akemi , Takano Toshimi , Kanao Hiroyuki , Watanabe Masayuki
Published: October 2022

Background: In recent years, the number of chemotherapy options for malignant tumors has increased due to the development of new drugs. In particular, the therapeutic effects of molecular-targeted drugs are, in some cases, more pronounced than those of conventional chemotherapy, and their introduction as a standard treatment is increasing. Due to the improved life prognosis, there are an increasing number of opportunities to consider fertility preservation for young patients. We report a case of ovarian insufficiency in a young woman caused by the tyrosine kinase inhibitor lenvatinib.
Case presentation: A 25-year-old woman received lenvatinib 8 mg/day for 98 days as preoperative chemotherapy for hepatocellular carcinoma. Blood testing the day before starting lenvatinib administration showed the following: luteinizing hormone (LH) 4.40 mIU/ml, follicle-stimulating hormone (FSH) 5.2 mIU/ml, estradiol (E2) 57.4 pg/ml, and age-equivalent hormone values. Amenorrhea occurred after the start of administration, and 48 days later, LH was 41.8 mIU/ml and FSH was 44 mIU/ml, values indicating a decrease in ovarian function. Hepatectomy was performed on the patient, and 49 days after the end of lenvatinib administration, blood test values improved to LH 4.5 mIU/ml, FSH 2.5 mIU/ml, and age-equivalent hormone values. Later, she began to have regular menstrual cycles once again.
Conclusions: Ovarian toxicity has not been recognized as a side effect of lenvatinib. However, amenorrhea and hypergonadotropinemia were observed in this patient after lenvatinib administration, as was primary ovarian insufficiencythought to be caused by the drug. Potential damage to ovarian function may need to be considered when molecular-targeted drugs with the same mechanism of action as lenvatinib are used in young women.
Quantum Gates Implementation for Reinforcement Learning Decision- Making Process
Authors: Maroufian Aarash
Published: October 2022

This paper introduces a novel method to improve the decision-making process of reinforcement learning agents via quantum information technology methods. In this approach, states |s〉 of the system are replaced by quantum states (eigenfunctions) of the system |ψ〉, in which a system can be in a superposition of states, and rewards of each step are calculated based on the calculated eigenvalues of the previous step. The agent decides the next step of the system based on the result of the quantum gate’s effect on the available options. Due to the high-speed, escalated performance of quantum algorithms, this method will improve the performance of reinforcement learning agents in unknown environments.
The effect of intravitreal injections for diabetic macular edema on intraocular pressure: Comparative study
Authors: Waly Mostafa
Published: October 2022

Objective: The study's goal is to determine how IOP gets affected following intravitreal injection of various anti-VEGF for diabetic macular edema (DME) over 2 months duration using applanation tonometery.
Methods: Nominated patients coming through the ophthalmology department of Kafrelsheikh and Tanta university hospitals who meet the presence inclusion criteria. 36 eyes were examined, including their IOP. By using a 30 gauge needle, intravitreal injection of ranibizumab (0.5 mg/0.05 ml), intravitreal injection of aflibercept (2 mg/0.05 ml) and intravitreal injection of Dexamethazone implant (Ozurdex) were administered through 3.5 to 4 mm after limbus. Then next IOP interpretation was measured 1 week, 1 month and 2 months of intravitreal injections for each drug. IOPs were measured also earlier pre injection "baseline IOP". All pressures were measured using the applantation tonometry.
Results: 36 Patients received intravitreal injection once and followed up for 2 months. 18 males and 18 females, their ages ranged from 45-76 years (mean 59.59 years (. Diabetic retinopathy observed clinically to be clinically significant macular edema and was proved by OCT and central foveal thickness was assessed. After 1 week and 2 months of intravitreal injections of the three materials no significant difference was noted in the IOP values (P value with 0.868 and 0.246 respectively). IOP measurement after 1 month was significantly higher in eyes injected with Ozurdex compared with eyes injected with ranibizumab or aflibercept (P value with 0.032). IOP returned to the normal range in three groups over the next month without any medical treatment. According to our study, the result of stratification with respect to age, and gender is not significant as p-value for age (0.893), gender (0.083).
Conclusion: In our study, frequency of raised IOP after anti VEGF were found more with Ozurdex than ranibizumab and aflibercept and that was more statistically significant after 1 month post injection. Though even without treatment IOP returns to normal within 2 months indicating Ozurdex safety as trustworthy antivegf theraby for resistant DME. Intravitreal injection of anti-VEGF drugs may have significant side effects so appropriate post-injection observation is crucial to reduce risk.
Human visceral leishmaniasis in Pernambuco-Brazil: a descriptive study, 2015 to 2020
Authors: Macena Leylyane da Silva , Pascoal Suedja Maria , Germinio Josefa Elaine Silva , Correia Bárbara Virgínia Mendonça da Silva
Published: October 2022

Introduction: Leishmaniasis is a systemic pathology caused by a parasite of the genres Leishmaniawhich Dogs are the main disease reservoir. The main parasite form of transmission in Brazil is through Lutzomyia longipalpis female bite.
Objective: The objective of this work is assessing the epidemiological profile of the VL in Pernambuco from 2015 to 2020.
Method: It is an observational, descriptive, cross-sectional, and retrospective from secondary data about LV rates in Pernambuco. Data were collected from DATASUS, SINAN and IBGE all Brazilian official systems.
Results: Pernambuco, located in Northeast region of Brazil presented high rates of Leishmaniasis more distribution in the backwoods of the state. Notification index of the state in the studied period were 175, 118, 185, 200, 181 and 113 respectively for each year from 2015 to 2020. In 2016 there was a reduction of 32% in cases in relation to 2015. In contrast, there was a significant increase in subsequent years 56.8%, 8,1%, 9,5% but in 2020 there was the smallest number of cases already notified, a decreasing of 37.6%. The mortality average of VL in the state of Pernambuco between 2015 and 2020 was 8.1%. Co-infection of the VL with HIV revealed an increase over the years.
Conclusion: The incidence of Co-infected patients with Visceral Leishmaniasis and HIV is a worrying factor. Also, sanitation is the main measure to reduce several neglected diseases, for that reason the development of social actions to raise awareness against the disease in all aspects are essential.
AI lead Supply Chain Optimization in Food Industry
Authors: pandey Sonal
Published: October 2022

There is no bigger industry on our planet than food and agriculture. In fact, the World Bank estimates that food and agriculture comprise about 10% of the global GDP (Gross Domestic Product). Despite a huge customer base, the food industry is facing unprecedented challenges in production, demand and regulations stemming from consumer trends. Due to the involvement of humans, the food industries are failing to maintain the demand-supply chain and lacking in food safety. To overcome these issues in food industries, industrial automation is the best possible solution. Automation is completely based on artificial intelligence (AI) or machine learning (ML) or deep learning (DL) algorithms. Artificial intelligence with data science can improve the quality of restaurants, cafes, online delivery food chains, hotels, and food outlets by increasing production by utilizing different algorithms for sales prediction. Artificial intelligence (AI), a radical concept developed by computer scientists in the 1950s, has tremendous applications in our daily lives. Artificial intelligence aims to learn human cognitive abilities and eventually surpass them. Currently, most AI models rely on deep neural networks, inspired by the human brain, which takes in a lot of raw data and expects results and learns the relationship between the two. The Global AI in the Supply chain market reached USD 5,610.8 Million in 2021a across the globe. Increasing attention to artificial intelligence, large statistics, analytics, and a widening scope are all driving AI growth in the supply chain market globally. Every autonomous and semi-autonomous program implements computer vision. There are several players operating in the global AI supply chain market, including FedEx, McLane Company, DHL, Amazon, CSX, XPO Logistics, C.H, and others. The machine learning segment accounted for the largest share of the global AI in the supply chain market. I tried to find these answers through my research article. • Importance of AI and how will impact in Supply chain in the mid-and long-term? • What are the ubiquitous movements in AI in the Supply chain? • What are the key strategies adopted by leading companies For AI in Supply chain logistics? • How the implementation of AI can make the Supply chain more efficient? To answer all these questions, I use secondary data and reports from various government agencies and did SWOT analyses to check where we can implement AI in supply chain optimization.
A New Covariance Estimator for Sufficient Dimension Reduction in High-Dimensional and Undersized Sample Problems
Authors: Olorede Kabir , Yahya Waheed
Published: October 2022

The application of standard-sufficient dimension reduction (SDR) methods for reducing the dimension space of predictors without losing regression information requires inverting the covariance matrix of the predictors. This requirement has plagued their success in high-dimensional data analysis. We propose a unified regression-type estimation strategy, which replaces the degenerate maximum likelihood covariance matrix with a new covariance estimator called Maximum Entropy Covariance (MEC) estimator at the dimension reduction step to produce accurate solutions. The MEC deals directly with singularity and instability of sample group covariance estimates and addresses loss of covariance information in the high-dimensional SDR applications using Maximum Entropy (ME) principle for the first time. We demonstrate the effectiveness of the proposed MEC-SDR methods using real-life Leukemia cancer and customers' electricity load profiles from smart meter data sets.
ASTCOQ02, a natural telomerase activator, lengthens telomeres in humans in a middle-aged population
A randomized, double-blind, placebo-controlled study
Authors: Jaeger de , Kruiskamp  , Voronska  , Lamberti  , Baramki  , Beaudeux  , Cherin
Published: October 2022

Telomeres are ribonucleoprotein structures that form a protective buffer at the ends of chromosomes and thus maintain genomic integrity during the cell cycle. Replicative telomere erosion can be compensated by a telomerase. Average telomeres size decreases with age and associated with aging-related diseases such as cancer and cardio-vascular disease. We previously reported that ASTCOQ02 (an Astragalus extract that contains astragaloside IV and cycloastragenol), a telomerase activator showed benefit in an open prospective study on telomere size and cardiovascular impact in healthy volunteers. Here we performed a randomized, double-blind, controlled trial over 6 months comparing the effect of ASTCOQ02 versus placebo on telomere length (TL) in 40 healthy volunteers (mean age 56.1 ± 6.0 years). Twenty subjects received ASTCOQ02 and 20 received placebo capsules. All 40 subjects completed the study with no adverse side effects reported at 6 months. Subjects taking ASTCOQ02 had significantly longer median (P = 0.01) and short TL (P = 0.004) and a lower percentage of short telomeres over the 6 months period whereas placebo group TL remained unchanged. This randomized, double-blind, placebo-controlled trial confirmed that ASTCOQ02 significantly lengthens both median and short telomeres by increasing telomerase activity, and reduces the percentage of short telomere (< 3 Kbp) in a statistically and possibly clinically significant manner. The results of this study also converge with the previous open prospective trial that found zero toxicity associated with intake of ASTCOQ02. ASTCOQ02 warrants further human studies on health, longer life expectancy and healthy aging.
The Story of the Starets Tsar as a Mental Phenomenon of Society in the 19th century
Authors:   National Research Tomsk State University, Mikhail S. Putilin
Published: October 2022

The legend of the Starets Tsar, known as Fyodor Kuzmich, is a unique fact of the folk mentality. Formed in the period of socio-political foreshadowing of social changes, it underwent a radical transformation in the process of existence. This story reflected the change of social priorities, characteristic of the period of social transformation. This determines the relevance of reference to the tale of the Starets Tsar, as every stage of transition to a new level of technological and social development of society generates similar phenomena in the mental public sphere. The study of the story of the Starets Tsar is not only a continuation of the research of Russian scholars on the topic of folk representations within the framework of new methodological concepts, but also an attempt to more clearly define the place of this story in the general classification of legends about the “returning savior”. In addition, historical science has long needed to provide its own analysis of this complex phenomenon of mentality and socio-cultural history, which has previously been purposefully studied only by literary scholars and theologians. The purpose of this study is to reveal the reflection of the mentality of the transition period in the story of the Starets Tsar Alexander I. Materials for the article included the sources belonging to different types, among which are clerical documentation, materials from printed publications of regional and all-Russian level, memoirs of contemporaries. Such methods of historical science as textual analysis and content analysis were used as well. As a result of the application of these methods the signs of the transitional mentality reflected in the story about the Starets Tsar were formulated. We made a conclusion that the development of the plot reflected the change of people’s mentality of the second half of the 19th century during the period of modernization transition. The story about the Starets Tsar began to form as a typical story about the “returning deliverer”, but in the process of its design it changed into a story about the “savior”. This fact reflects the change in the folk mentality of the period of the modernization transition in the second half of the XIXth century. The perspective of the study is the continuation of research in the field of changing mentalities in the XIXth century, in their relationship.
A la recherche des critères du contrat de travail. Réflexion à partir des arrêts Uber du 30 mai 2022
Authors: Witzig Aurélien
Published: October 2022

Le Tribunal fédéral a rendu récemment deux arrêts dans des affaires concernant l'entreprise numérique Uber. Il s'agissait de déterminer si les prestataires de la plateforme devaient être qualifiés de travailleurs salariés ou d'indépendants. La Haute cour a tranché en faveur de la première possibilité, dans la lignée des évolutions jurisprudentielles actuelles. La présente contribution tente de tirer les conséquences de la clarification désormais apportée, en s'interrogeant plus largement sur le cadre méthodologique le plus adéquat pour la recherche des critères du contrat du travail et sur le choix de tels critères, en droit positif. Nous arrivons à la conclusion que le mixte pragmatique actuellement mis en œuvre par la jurisprudence a vocation à produire ses effets dans le cadre de l'économie numérique, et nous proposons une définition conceptuelle du droit du travail comme le droit visant à protéger les personnes qui mettent leur force de travail à disposition de l'entreprise d'autrui dans des circonstances où diverses protections doivent, selon la conception sociale qui a cours, leur être accordées.

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Das Bundesgericht fällte kürzlich zwei Urteile in Fällen rund um das digitale Unternehmen Uber. Dabei ging es um die Frage, ob die über die Plattform vermittelten Fahrerinnen und Fahrer als Arbeitnehmende oder als Selbstständige einzustufen sind. Das Gericht entschied zugunsten der ersten Variante und folgte damit den aktuellen Entwicklungen in der Rechtsprechung. Der vorliegende Beitrag versucht, die Konsequenzen aus der nunmehr erfolgten Klärung zu ziehen, indem er sich eingehender mit der Frage befasst, welcher methodische Rahmen für die Suche nach den Kriterien des Arbeitsvertrags und die Wahl solcher Kriterien im positiven Recht am besten geeignet ist. Wir kommen zum Schluss, dass die pragmatische Mischung, die derzeit von der Rechtsprechung angewandt wird, auch im Rahmen der digitalen Wirtschaft Wirkung zeigen wird, und schlagen eine konzeptionelle Definition des Arbeitsrechts als Recht zum Schutz von Personen vor, die ihre Arbeitskraft einem Unternehmen unter Umständen zur Verfügung stellen, unter denen ihnen nach der herrschenden gesellschaftlichen Auffassung verschiedene Schutzmechanismen gewährt werden müssen.
Evaluation of Hollow-tine Core Aerification Recycling on a Sand-based Putting Green Soil Properties and Playability
Authors: Lindsey Alex J. , Thoms Adam W. , Christians Nick E. , Pease Ben W.
Published: October 2022

Aeration and sand topdressing are important cultural practices for organic matter management on golf course putting greens. Many golf courses lack the budget for applications of new sand topdressing material. A 2-year study was conducted to investigate the effect of recycling sand from hollow-tine aerification cores on a sand-based creeping bentgrass (Agrostis stolonifera) putting green soil properties and playability. Treatments included traditional [T (cores removed and sand topdressed)], verticut [V (cores broken up with verticutter)], and recycle [R (cores recycled using a core recycler)]. There were no differences in root zone organic matter, bulk density, soil porosity, infiltration rates, percent sand recovered during mowing, surface firmness, and ball roll distance between treatments during the study. Immediately after aerification treatments, T had the highest percent green cover (PGC) (38.3%) compared with V (26.9%) and R (26.8%), indicating that T offered the least sand present on the surface. Seven days after treatments, there was no difference in PGC (85.3% to 90.1%), indicating all treatments recovered similarly. Alternative aerification treatments V and R could be useful techniques to minimize or reduce the amount of sand used for backfilling core aeration holes without compromising the putting green soil properties and playability.
The Universal and Historic Dimension of Circumstance in Fiqh Perspective
Authors: ASLAN Recep , YILMAZ İsmail
Published: October 2022

Historicity is the existence of a provision in a specific historical, geographical and social environment, its existence and continuation dependent on the existence and continuation of these conditions. When it comes to historicity/locality in the Sunnah, the historical, regional, social, political, cultural and economic features specific to his period, which are reflected in the words, behaviors and actions of the Prophet, come to mind. If circumcision is accepted as lived practices, they reflect the mental, linguistic and vital practices of the society they are in. As a messenger of God, as a prophet he raised unprecedented individuals, built a new society, and introduced new values and practices, but ultimately he did so in the VII century succeeded on the social ground of the Arabian Peninsula at the turn of the century. This finding is Understanding and interpreting the hadiths, which are the data of the Sunnah of the Prophet that have reached our age, are very important for the interpretation of the law in terms of jurisprudence. To put it more concretely, Mr. The information in the hadith collections in which the events in which the Prophet took place were recorded, although some of them were recorded from the mouth of the Prophet, VII. Reading it independently of the rhetoric and perceptions of the 20th century Arab society will lead to misunderstandings. There is no doubt that the narrations containing these qualities may have a universal aspect in terms of the message they want to convey. However, it is not necessary for the hadiths transmitted in matters that are related to the special situations of individuals or that require knowledge and skills to contain a message that belongs to the whole society. What is understood from universality in sunnah is that hadith and sunnah contain a message belonging to humanity. It is the realization of the purpose that the Prophet cares about when he is subject to that message. One of the steps to be taken in order to bring circumcision into the modern age is to understand the issue of locality and universality in circumcision correctly. In this context, in this paper, the local and universal aspects of circumcision will be discussed.
Asian apparel industry: geographic specifics and key development areas
Authors:   Lomonosov Moscow State University, Akimova Varvara ,   Institute of Applied Economic Research, Russian Presidential Academy of National Economy and Public Administration, Kuptsova Margarita ,   Lomonosov Moscow State University
Published: October 2022

The global textile and apparel sector historically played a key role in the developing economies of Asia, which now account for three quarters of global apparel exports. Today as new countries embark on the path of export-oriented industrialization, the geography of the industry is expanding due to the emergence of new clothing manufacturing centers in Asia. The article is dedicated to a comprehensive analysis of the spatial organization of the garment industry in the Asian region. The modern dynamics of the economic indicators of the industry at the national level is considered, key trends are indicated. The parameters of the suppliers search in combination with the location factors of the textile and apparel industry are revealed, and their influence on the spatial pattern of the industry is explained. At the regional level, the identification, qualitative and quantitative analysis of the concentration areas of the textile and apparel industry is carried out based on location of production sites of the leading companies in the industry. In total, 14 areas of the export-oriented textile and apparel industry in Asia have been highlighted and divided into three types based on their product and technological specialization, the size and ownership structure of enterprises, and backward linkages to the textile sector. It was revealed that the trend of shift of garment production continues both at the level of national economies (to other countries) as well as at the regional level (from large centers to the inner regions of countries), however, the return on the model of constant search for new production facilities for cost reduction is decreasing.
Geoinformation analysis with the construction of a neural network model for predicting location of archaeological monuments in the landscapes of South-Eastern Altai
Authors:   St. Petersburg State University, Glebova Anastasia , Sergeev Igor ,   St. Petersburg State University, Bykov Nikolay ,   Institute of Water and Environmental Problems SB RAS
Published: October 2022

The article is devoted to the identification of landscape patterns of the location of archaeological sites in the South-East Altai using GIS and machine learning. The information database of archaeological sites of South-Eastern Altai was created based on literary sources, the authors' own field research. Schemes of distribution of archaeological sites according to some landscape features: absolute height; position in relation to watercourses; slopes; exposition; solar radiation intensity in June; Intensities of solar radiation for December was created on the basis of geoinformation analysis of the relief of the territory and the available archaeological data. The obtained statistical regularities of the distribution of archaeological sites in the landscapes of South-Eastern Altai were the basis for the creation and verification of the algorithm of a machine-learning model - a neural network. Based on the results, a forecast map of the location of archaeological sites was created. The greatest probability of discovering new archaeological objects could be provided by the following landscape parameters, no further than 500-600 m from the river with a slope steepness of up to 4 degrees, with high intensity and summer (June) solar radiation and with an exposure of slopes: southern, south-eastern and western. Unexplored archaeological sites in South-East Altai are most likely located along river valleys in the middle and lower reaches, at the confluence of rivers, along the periphery of intermountain basins, or on wide flat areas of above-floodplain terraces of river valleys. The data obtained make it possible to assess the contribution of landscape features to the spatial distribution of religious buildings of ancient peoples and provide opportunities for the search for new archaeological sites.
Emotional Contagion Scale and Mental Health Status during the First Wave of COVID-19 Pandemic, National Assessment
Authors: Amer Samar A. , Abd-Ellatif Eman Elsayed , Hughes Peter , Al-Enazi Hadi Mahdi Ghazai , AlHasan Ahmed , Amer Mostafa A. , Alruhaimi Asma Faleh , Elsayed Mohamed
Published: October 2022

Background:

This great pandemic of COVID-19 has been a unique stressor that affected all communities in 2020. This study aims to examine the prevalence of anxiety and depression due to the COVID-19 pandemic in Saudi Arabia and to study the emotional cognition scale in the Kingdom of Saudi Arabia (KSA) in relation to the COVID-19 pandemic.

Methodology:

A descriptive cross-sectional study was conducted on 857 inhabitants randomly selected from the 13 administrative regions of Saudi Arabia, using a validated self-administrated questionnaire comprising six sections. The collected data were summarized and analyzed.

Results:

Among the majority of the studied participants, 377 (44.0%) were aged from 35 to less than 50 y. There were 489 (57.1%) females and 368 (42.9%) males, 616 (71.9%) Saudi nationals, 715 (83.4%) university-educated or postgraduate, 619 (72.2%) unmarried and 238 (27.8%) married, and 663 (77.4%) living in areas under partial lockdown. The resultant elevated total depression score was statistically significant (p<0.05) for the following: participants younger than 35y, females, Saudis, those with lower education levels, those who were married, students, those with work suspension during the COVID-19 pandemic, and amongst those who experienced complete lockdown. Among the majority of the studied participants, 355 (41.2%) showed mild depression, and 281(32.6) showed moderate anxiety, and were in the growth zone. In addition, the elevated total anxiety score was statistically significant (p<0.05) amongst the following; younger participants, females, Saudi nationals, those with lower educational levels, those who were unmarried, students, those with telework, and those with no curfew.

Conclusion:

The adverse mental health effects were more prevalent among particular groups of the population, such as females, adults under 35 years old, students, those with lower educational attainments, and those suffering from chronic illnesses. Anxiety was significantly correlated with depression. The practice of preventive measures, e.g., wearing masks, and social distancing to prevent the spread of COVID-19, may have had psychological benefits during the pandemic.

We assessed the mental health status in Saudi Arabia during the first wave of the COVID-19 pandemic. Mild depression and moderate anxiety were prevalent problems, with many determinants and interrelations. Fear was the most infectious emotion, while happiness was the highest.
fantasmas industriales del pasado y una aproximación a la dimensión pragmática de la semiosis: caso fábrica de Cerveza Pilsen Trujillo, La Libertad, Perú
Authors: Velásquez García Juan , Moya Avalos Willman , Rodriguez Mogollón Carlos
Published: October 2022

El objetivo de esta investigación fue develar los valores del patrimonio industrial, caso de la Fábrica de Cerveza Pilsen Trujillo en la Libertad Perú, desde la perspectiva de la dimensión pragmática de la semiosis. Actualmente, en Perú los edificios industriales son ignorados por las instituciones encargadas del patrimonio cultural. 

Esta investigación fue cualitativa porque se trató de descubrir significados culturales pertenecientes al patrimonio cultural industrial desde la perspectiva de los usuarios.

Finalmente, por las evidencias, se concluyó que los objetos patrimoniales, como la Fábrica de Cerveza Pilsen Trujillo, tienen atributos comunicacionales, por tanto, la semiosis está presente en ellos, especialmente la pragmática, porque un bien patrimonial solamente se puede entender cuando este tiene relación con los usuarios.
Daniel Estrada Pérez y el Centro Histórico de Cusco: Un análisis de su gestión 1990-1992
Authors: Cusicuna Vilca Lisbeth , Laurente Palomino Sonia , Arias Echegaray Rosa , Garcia Barrios Jimmy
Published: October 2022

La gestión municipal de Daniel Estrada Pérez y su intervención en los espacios públicos del Centro Histórico de Cusco, fue algo que ninguna otra autoridad hasta ese entonces había realizado; Estrada supo dirigir y emplear diversos mecanismos para insertar el Cusco a la modernidad. El objetivo del artículo es analizar, conocer y sintetizar las intervenciones patrimoniales realizadas (entre aciertos y desaciertos) en el Centro Histórico durante la gestión municipal de Estrada entre 1990 y 1992, se llegó a considerar esta etapa como punto de partida para la recuperación de la identidad cultural cusqueña. Para lograr el propósito de la investigación se empleó la técnica de acopio de información del diario El Comercio de Cusco; al mismo tiempo, se realizó una amplia revisión bibliográfica contrastando fuentes y complementada con una entrevista efectuada al arquitecto Roberto Samanez Argumedo.
De frailes a escolta. Valor histórico del Cuartel de Barbones de Lima (1825-1879)
Authors: Jara Boza Yonatan
Published: October 2022

En el distrito de El Agustino, apenas a la salida de la antigua muralla de Lima, se ubica el histórico y antiguo Cuartel Barbones —valioso conjunto donde entre otras dependencias se acuartela la escolta del presidente de la República, de importante participación en el tradicional cambio de guardia en la Plaza Mayor— cuya larga historia comienza cuando fue convento y hospital de la casi desaparecida orden religiosa de los betlemitas. En esta investigación se ha buscado contextualizar los hechos ocurridos entre 1825 y 1879, años de la entonces nueva República Peruana, de la relación de la Iglesia con el Ejército y de su impacto en el patrimonio edificado religioso teniendo como ejemplo al antiguo Hospital de Convalecientes Nuestra Señora del Carmen.
Análisis de la Gestión Municipal Provincial de Cusco2011 – 2014: Sector SG-5 Barrio Tradicional de Santa Ana
Authors: Aragon Coricasa Dayan , Mamani Palomino Nancy , Matencio Carpio Jhojhana , Quillahuaman Quispe Mario , Paucar Mora Kevin
Published: October 2022

Entre 2011 y 2014 se desarrolló la gestión municipal del economista Luis Flores García, protagonista de la intervención del Centro Histórico del Cusco. Se destacó por su enfoque social y cultural; no obstante, acciones de revalorización de lo cusqueño, dieron inicio a polémicas en los medios de comunicación; sin embargo, un gran sector de la población lo recuerda con gran cariño porque apoyó el desarrollo de planes urbanos muy demandados. Algunos de sus proyectos, resultaron casi imperceptibles a los vecinos, pero los técnicos advierten que estos mejoraron notablemente la calidad de vida de la ciudadanía, a mediano y largo plazo. El presente artículo analiza dicha gestión y cómo influyó en el barrio tradicional de Santa Ana.
Matinée, Vermouth y… ¿noche? Caso de estudio: el cine Susy de San Juan de Miraflores a través de sus sujetos patrimoniales (Lima, Perú)
Authors: Aparicio Ramirez Diego Alberto
Published: October 2022

Durante muchos años, los cines de sala única marcaron un hito en el contexto mundial y nacional; El objetivo del presente artículo, es comprender las características formales, de uso y valor simbólico del cine Susy, además de su relación contextual, su influencia sobre el desarrollo social y económico del distrito de San Juan de Miraflores, así como también los valores patrimoniales reconocibles y los grados de afinidad de los mismos por parte de los sujetos patrimoniales involucrados con el cine, a fin de concluir su inclusión dentro de la esfera de patrimonio cultural.
Corporate Social Responsibility Practices at PEMEX: An Analysis on stakeholders
Authors: Esparza Rodríguez Saúl Alfonso , Martínez-Arroyo Jaime Apolinar , Esquivel Fernández Enrique , García Tapia Gabino
Published: October 2022

Nowadays, adopting an organizational approach focused on sustainable practices aimed at promoting the responsible use of resources can represent a competitive advantage for companies, which can thus keep costs low and reputation high. An example of a company that adopts this approach is Petróleos Mexicanos (PEMEX). For this research, an analysis of the external management structure of the company –whose Interest Groups includes indigenous communities, civil society, government, media, suppliers and customers— was carried out based on the information provided on its website. The evaluation of the organization’s performance in terms of its relationship with relevant stakeholders includes the annual reports provided by the company, using a matrix that includes the results obtained each year in terms of stakeholder management. The results show a decreasing tendency of the company on its investment in socially responsible practices, which contradicts the justification of such investment to promote and boost the competitive advantage of the company.
Família, finanças e poder no Brasil: a trajetória do grupo Itaú (1943-2008)
Authors: Brandão Rafael Vaz da Motta
Published: October 2022

Este artigo tem como objetivo analisar a trajetória do grupo Itaú no período compreendido entre 1943, ano em que foi fundado o Banco Central de Crédito, e 2008, quando foi realizada a fusão com o Unibanco. Controlado pelas famílias Setúbal e Villela, o Itaú transformou-se, ao longo da segunda metade do século XX, em um dos mais poderosos grupos econômicos do Brasil. A hipótese defendida no texto é de que a trajetória do Itaú deve ser compreendida a partir de três grandes fases: 1) origem em um banco de atuação regional, o Banco Central de Crédito; 2) expansão, bene­ficiada pela política de conglomeração bancária da Ditadura Militar, e 3) consolidação, com a participação nos processos de privatização dos bancos estaduais na segunda metade da década de 1990.
Efecto del acceso al programa Familias en Acción sobre la participación política de las mujeres en Colombia
Authors: López Barrera Lorena Andrea
Published: October 2022

Este documento analiza el alcance de los programas sociales focalizados con transferencias condicionadas en la participación política femenina. Para ello hace un estudio de caso del programa Familias en Acción en Colombia entre los años 2007-2014, mediante estimaciones de una unión de cortes transversales y de un pseudo panel, ambos construidos con datos de LAPOP y del CEDE. Los resultados arrojan una relación significativa y positiva en la asistencia a algunas de las organizaciones civiles. Sobre la relación con las votaciones, es también positiva, pero solo significativa para las regionales. Adicionalmente, se discuten los posibles mecanismos que pueden explicar esta relación.