bluuebunny/crossref_metadata_2025 huggingface dataset:
GreenLink: An Energy Efficient Scatternet Formation for BLE Devices
Authors: Wang Xiaoliang , Xu Ke , Mao Bo
Published: November 2018

Formation technology of Bluetooth scatternet has been researched for over a decade and promoted by rapid development of wearable computing. Limited by technical features, the traditional scatternet formation technology has not been widely used in real commercial chipsets. As new features are introduced into the Bluetooth core field, the ability to use Bluetooth Low Energy (BLE) technology to construct a network becomes the reality and puts forward new challenges. The scatternet formation technology facing to BLE and wearable devices requires significant improvement in energy efficiency. According to our experiments, 92% of the system energy consumption can be attributed to central nodes. In this paper, we presented a Bluetooth scatternet formation technology focused on energy efficiency, GreenLink, which minimizes the amount of central nodes by enhancing system aggregation degree to ensure excellent energy‐saving performance. Meanwhile, we implemented a prototype of GreenLink on Nordic nRF51822 chipsets, conducted experiments, and verified in practice. According to the experiments, GreenLink used only 30% central nodes and reduced 50% system energy consumption compared with traditional technology.
An Effective Integrity Verification Scheme of Cloud Data Based on BLS Signature
Authors: Luo Xiling , Zhou Zequan , Zhong Lin , Mao Jian , Chen Chaoyong
Published: November 2018

Cloud storage services allow users to outsource their data remotely to save their local storage space and enable them to manage resources on demand. However, once users outsourced their data to the remote cloud platform, they lose the physical control of the data. How to ensure the integrity of outsourced data is the major concern of cloud users and also is the main challenge in the cloud service deployment. Limited by the communication and computation overheads, traditional hash-based integrity verification solutions in the stand-alone systems cannot be directly adopted in remote cloud storing environment. In this paper, we improve the previous privacy preserving model and propose an effective integrity verification scheme of cloud data based on BLS signature (EoCo), which ensures public audition and data privacy preserving. In addition, EoCo also supports batch auditing operations. We conducted theoretical analysis of our scheme, demonstrated its correctness and security properties, and evaluated the system performance as well.
Fake and Real Massaging at the Same Time with QR Code in Web Services for Different Users
Authors: Yesiltepe Mirsat , Kurulay Muhammet
Published: November 2018

At present, the notion of a cloud has expanded so much that there is no area of knowledge other than the concept of cloud. The most important reason for this is the ambiguity in the definition of this concept in the literature. Some have used the concept of a mobile cloud to create private cloud environments, while others have defined the cloud as a complex environment consisting of many different entities and layers, while others regard the cloud as parallel, discrete, and grid. In other words, the concept of cloud can sometimes be limited by the user devices and sometimes by the user devices. QR code, which is a precise and accurate way of communicating a text or symbol to the other side, is very broad, as is the concept of cloud use. The use of this technology is increasing with the availability of data encryption algorithms. As an abbreviation of the term “QR code,” the QR phrase “Quick Response,” which is the English language name, is used. In this study, when the same request is requested for different users (clients) in the web service, the response generated by the server at one time is sent to the different users at one time and the users get different messages. It is intended to reduce the load on the server and respond more efficiently to clients. Scrambled steganographic QR codes will be used for these operations. Some of the highlights of the paper are different message transmission with the same QR code to different users in web services and message verification with a hash value, using fake keys and advantage of changeable security mechanism.
Ageing, Disability, and Spinal Cord Injury: Some Issues of Analysis
Authors: Pili Roberto , Gaviano Luca , Pili Lorenzo , Petretto Donatella Rita
Published: November 2018

Spinal cord injury is a disabling disorder, worldwide spread, with important consequences on functioning and health conditions and impacts on physical, psychological, and social well-being. The consequences are related to the lesion itself and to other complications related to the lesion. In the last decades, there have been an increasing of the mean ages of onset and also an increase in life expectancy after the lesion. So, differently from the past, people with spinal cord injury can age after the lesion. Taking into account the need to share data and information about specific disabling conditions and their relationship with ageing, this paper aims to discuss some issues from recent literature on the relationship between aging and disability in the spinal cord injury, according to a narrative review approach. A narrative review of the literature on ageing and spinal cord injury was undertaken. Search was based on the following electronic databases: PubMed/Medline and Ovid/PsychINFO. A combination of the following keywords was used: (1) “ageing” or “aging” and (2) “spinal cord injury” or “spinal cord lesion” and (3) disability. Data on consequences of the lesion in the life of aging people, secondary health conditions, life expectancy, participation, and quality of life are discussed. Then, a brief discussion of clinical issues and the role of interventions aimed to promote wellbeing, health, quality of life, and participation of people with spinal cord injury is proposed.
Modelling and Qualitative Analysis of Water Hyacinth Ecological System with Two State‐Dependent Impulse Controls
Authors: Fu Jin-Bo , Chen Lan-Sun
Published: November 2018

Water hyacinth and its ecological invasion have negative impacts on diversity of indigenous species and ecosystems, which becomes one of the hotspots in current ecological research. In this paper, a water hyacinth ecological system with two state‐dependent impulse controls is studied. Firstly, we define the successor functions of semicontinuous dynamic system and give existence theorems of order‐1 periodic solution and order‐2 periodic solution of such system. Secondly, we analyze singular points of the system without impulsive state feedback control qualitatively and get the condition for focus point. Thirdly, we obtain the sufficient condition under which the system has an order‐1 or order‐2 periodic solution through the method of successor function and prove the stability of the order‐1 or order‐2 periodic solution by the analogue of Poincaré’s criterion. Furthermore, some examples and numerical simulations are given to illustrate our results.
Multiobject Tracking in Videos Based on LSTM and Deep Reinforcement Learning
Authors: Jiang Ming-xin , Deng Chao , Pan Zhi-geng , Wang Lan-fang , Sun Xing
Published: November 2018

Multiple‐object tracking is a challenging issue in the computer vision community. In this paper, we propose a multiobject tracking algorithm in videos based on long short‐term memory (LSTM) and deep reinforcement learning. Firstly, the multiple objects are detected by the object detector YOLO V2. Secondly, the problem of single‐object tracking is considered as a Markov decision process (MDP) since this setting provides a formal strategy to model an agent that makes sequence decisions. The single‐object tracker is composed of a network that includes a CNN followed by an LSTM unit. Each tracker, regarded as an agent, is trained by utilizing deep reinforcement learning. Finally, we conduct a data association using LSTM for each frame between the results of the object detector and the results of single‐object trackers. From the experimental results, we can see that our tracker achieves better performance than the other state‐of‐the‐art methods. Multiple targets can be steadily tracked even when frequent occlusions, similar appearances, and scale changes happened.
Modeling and Stability Analysis for Markov Jump Networked Evolutionary Games
Authors: Zhao Guodong
Published: November 2018

This paper investigates the algebraic formulation and stability analysis for a class of Markov jump networked evolutionary games by using the semitensor product method and presents a number of new results. Firstly, a proper algorithm is constructed to convert the given networked evolutionary games into an algebraic expression. Secondly, based on the algebraic expression, the stability of the given game is analyzed and an equivalent criterion is given. Finally, an example works out to support the new results.
The Fractional Order PID Method with a Fault Tolerant Module for Road Feeling Control of Steer-by-Wire System
Authors: Xu Fei-xiang , Liu Xin-hui , Chen Wei , Zhou Chen , Cao Bing-wei
Published: November 2018

To improve the road feeling of the steer-by-wire (SBW) system, a fractional order PID (proportion-integral-derivative) method with a fault tolerant module is proposed in this paper. Firstly, the overall road feeling control strategy of the SBW system is introduced, and then the mathematical model of road feeling control is established. Secondly, a fractional order PID (FOPID) controller is designed to control torque of the road feeling motor. Furthermore, genetic algorithm (GA) is applied to tune the FOPID controller’s parameters. Thirdly, a fault tolerant module aiming at potential failures of the motor’s torque sensor is studied to improve the reliability of the system. Kalman Filter (KF) algorithm is utilized in the fault tolerant module so as to detect failures of the motor’s torque sensor, and then fault tolerant module reconfigures the motor’s torque estimated by KF as a substitute when the torque sensor fails. Finally, simulations based on MATLAB are performed with the proposed control strategy to identify its performance, and the results demonstrate that the proposed control method is feasible and accurate.
An Interview‐Based Study of Pioneering Experiences in Teaching and Learning Complex Systems in Higher Education
Authors: Lizier Joseph T. , Harré Michael S. , Mitchell Melanie , DeDeo Simon , Finn Conor , Lindgren Kristian , Lizier Amanda L. , Sayama Hiroki
Published: November 2018

Due to the interdisciplinary nature of complex systems as a field, students studying complex systems at university level have diverse disciplinary backgrounds. This brings challenges (e.g., wide range of computer programming skills) but also opportunities (e.g., facilitating interdisciplinary interactions and projects) for the classroom. However, little has been published regarding how these challenges and opportunities are handled in teaching and learning complex systems as an explicit subject in higher education and how this differs in comparison to other subject areas. We seek to explore these particular challenges and opportunities via an interview‐based study of pioneering teachers and learners (conducted amongst the authors) regarding their experiences. We compare and contrast those experiences and analyze them with respect to the educational literature. Our discussions explored approaches to curriculum design, how theories/models/frameworks of teaching and learning informed decisions and experience, how diversity in student backgrounds was addressed, and assessment task design. We found a striking level of commonality in the issues expressed as well as the strategies handling them, for example, a significant focus on problem‐based learning and the use of major student‐led creative projects for both achieving and assessing learning outcomes.
Relation of Country‐of‐Origin Effect, Culture, and Type of Product with the Consumer’s Shopping Intention: An Analysis for Small‐ and Medium‐Sized Enterprises
Authors: Berbel-Pineda Juan Manuel , Palacios-Florencio Beatriz , Santos-Roldán Luna , Ramírez Hurtado José M.
Published: November 2018

To obtain information about foreign markets is a very complex task for small‐ and medium‐sized enterprises. This work’s aim is to find out how certain variables are related to the consumer’s shopping intention. It will help these firms to get a better knowledge of this intention. The work is specifically centred on products related to the gastronomy of a particular place. Through a sample of 154 tourists who visited this destination, we sought to know these products’ degree of acceptation. Via structural equation modelling, it has been possible to determine the relevance which the variables of country of origin, gastronomic culture, and type of product have regarding the shopping intention. The work’s novelty is to contribute a methodology of gathering information in the destination on the likes and behaviour patterns of foreign consumers without the need of costly research in their countries of origin.
Effect of User Mobility upon Trust Building among Autonomous Content Routers in an Information‐Centric Network
Authors: Konorski Jerzy , Grochowski Jakub
Published: November 2018

The capability of proactive in‐network caching and sharing of content is one of the most important features of an information‐centric network (ICN). We describe an ICN model featuring autonomous agents controlling the content routers. Such agents are unlikely to share cached content with other agents without an incentive to do so. To stimulate cooperation between agents, we adopt a reputation and trust building scheme that is able to explicitly account for both objective current content availability and subjective willingness to cooperate. The scheme is further complemented with a so‐called one‐time goodwill mechanism introduced to avoid penalizing agents failures to provide temporarily unavailable content. In a simulated ICN environment under a modified Random Waypoint user mobility model, we investigate the resiliency of the reputation and trust building scheme to subversion, that is, strategic (selfish or malicious) agents acquiring higher trust values than honest ones, for varying user mobility scenarios. The scheme proves resilient in low‐mobility scenarios, while increased user mobility is shown to have a negative effect. The one‐time goodwill mechanism partly remedies this for high‐mobility scenarios. We validate the results by comparison with an existing reputation and trust building scheme and with an alternative user mobility model.
Time-Optimal Trajectory Planning along Parametric Polynomial Lane-Change Curves with Bounded Velocity and Acceleration: Simulations for a Unicycle Based on Numerical Integration
Authors: Wu Chien-Sheng , Chiu Zih-Yun , Liu Jing-Sin
Published: November 2018

G2 lane-change path imposes symmetric conditions on the path geometric properties. This paper presents the comparative study of time-optimal velocities to minimize the time needed for traversal of three planar symmetric parametric polynomial lane-change paths followed by an autonomous vehicle, assuming that the neighboring lane is free. A simulated model based on unicycle that accounts for the acceleration and velocity bounds and is particularly simple for generating the time-optimal path parameterization of each lane-change path is adopted. We base the time-optimal trajectory simulations on numerical integration on a path basis under two different end conditions representing sufficient and restricted steering spaces with remarkable difference in allowable maximum curvature. The rest-to-rest lane-change maneuvering simulations highlight the effect of the most relevant path geometric properties on minimal travel time: a faster lane-change curve such as a quintic Bezier curve followed by a unicycle tends to be shorter in route length and lower in maximum curvature to have achievable highest speed at the maximum curvature points. The results have implications to path selection for parallel parking and allow the design of continuous acceleration profile via time scaling for smooth, faster motion along a given path. This could provide a reference for on-road lane-change trajectory planning along a given path other than parametric polynomials for significantly more complex, complete higher-dimensional highly nonlinear dynamic model of autonomous ground vehicle considering aerodynamic forces, tire and friction forces of tire-ground interaction, and terrain topology in real-world.
Micromorphology and Mechanical and Dielectric Properties of Bismaleimide Composite Modified by Multiwalled Carbon Nanotubes and Polyethersulfone
Authors: Chen Yufei , Geng Chengbao , Han Yang , Chai Mingzhuo , Guo Hongyuan , Yue Chunyan , Ma Yingyi
Published: November 2018

Multiwalled carbon nanotubes (MWCNTs) were modified by oxidizing agent to obtain O-MWCNTs, and the surface of it was coated with active group. 4,4′-Diaminodiphenylmethane bismaleimide (MBMI) was used as matrix, 3,3′-diallyl bisphenol A (BBA) and bisphenol-A diallyl ether (BBE) were used as reactive diluent, polyethersulfone (PES) as toughening agent, and O-MWCNTs as modifier; OMWCNT/PES-MBAE composite was prepared through in situ sol-gel method. The effect of PES and OMWCNTs on the mechanical and dielectric properties of composite was analyzed, and the microstructure was examined by transmission electron microscope (TEM) and scanning electron microscope (SEM). The mechanism of composite toughened by PES and OMWCNTs was observed and analyzed. The results showed that Diels-Alder reaction between MBMI and allyl compounds occurred completely and unsaturated double bond disappeared. O-MWCNTs and PES resin dispersed smoothly in polymer matrix and were used as reinforcement, and PES resin and O-MWCNTs could synergistically improve the properties of the composite and exhibited a typical ductile fracture. The impact and bending strengths were 16.09 kJ/m2 and 153.57 MPa, which were 74.32% and 53.08% higher than those of the MBAE matrix, respectively, and the dielectric constant and the dielectric loss were 3.76 (100 Hz) and 2.79 × 10−3 (100 Hz), when the content of PES was 2 wt% and O-MWCNTs was 0.02 wt%. The outstanding properties of the material made it play an important role in high-performance insulating material applications.
An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
Authors: Freedman Joshua D. , Duffy Margaret R. , Lei-Rossmann Janet , Muntzer Alice , Scott Eleanor M. , Hagel Joachim , Campo Leticia , Bryant Richard J. , Verrill Clare , Lambert Adam , Miller Paul , Champion Brian R. , Seymour Leonard W. , Fisher Kerry D.
Published: November 2018

Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. Here, we modified the oncolytic group B adenovirus enadenotucirev to express a stroma-targeted bispecific T-cell engager (BiTE). This BiTE bound fibroblast activation protein on cancer-associated fibroblasts (CAF) and CD3ϵ on T cells, leading to potent T-cell activation and fibroblast death. Treatment of fresh clinical biopsies, including malignant ascites and solid prostate cancer tissue, with FAP-BiTE–encoding virus induced activation of tumor-infiltrating PD1+ T cells to kill CAFs. In ascites, this led to depletion of CAF-associated immunosuppressive factors, upregulation of proinflammatory cytokines, and increased gene expression of markers of antigen presentation, T-cell function, and trafficking. M2-like ascites macrophages exhibited a proinflammatory repolarization, indicating spectrum-wide alteration of the tumor microenvironment. With this approach, we have actively killed both cancer cells and tumor fibroblasts, reversing CAF-mediated immunosuppression and yielding a potent single-agent therapeutic that is ready for clinical assessment.

Significance:

An engineered oncolytic adenovirus that encodes a bispecific antibody combines direct virolysis with endogenous T-cell activation to attack stromal fibroblasts, providing a multimodal treatment strategy within a single therapeutic agent.
Predictive Early Recurrence Factors of Preoperative Clinicophysiological Findings in Pancreatic Cancer
Authors: Suzuki Shuji , Shimoda Mitsugi , Shimazaki Jiro , Maruyama Tsunehiko , Oshiro Yukio , Nishida Kiyotaka , Sahara Yatsuka , Nagakawa Yuichi , Tsuchida Akihiko
Published: November 2018

Background: We aimed to evaluate the use of preoperative clinicophysiological parameters as predictive risk factors for early recurrence of pancreatic ductal adenocarcinoma (PDAC) after curative resection. Methods: A total of 260 patients who underwent pancreatic resection for PDAC between 2007 and 2015 were examined retrospectively. We divided the patients into those with early recurrence (within 6 months; group A, n = 52) and those with relapse within ≥6 months or without recurrence (group B, n = 208). Data regarding clinicophysiological parameters were analyzed as predictors of disease-free survival (DFS). These factors were analyzed by χ2 tests on univariate analysis and Cox proportional hazard models on multivariate analyses. Kaplan-Meier survival curves were generated using log-rank tests. Results: Groups A and B had significantly different preoperative carbohydrate antigen 19-9 (CA19-9) levels, carcinoembryonic antigen (CEA) levels, and curability. Univariate and multivariate analysis showed that CA19-9 and CEA were independent prognostic factors for early recurrence. Patients with CA19-9 levels > 124.65 U/mL had significantly shorter DFS than those with lower levels, as did patients with CEA levels > 4.45 ng/mL. Conclusions: Our results show that elevated CA19-9 (> 124.65 U/mL) and CEA (> 4.45 ng/mL) were independent predictors of early recurrence after pancreatic resection in PDAC patients.
Interrelationship of Opioid Dependence, Impaired Impulse Control, and Depressive Symptoms: An Open-Label Cross-Sectional Study of Patients in Maintenance Therapy
Authors: Peters Lynn , Soyka Michael
Published: November 2018

Objective: A growing number of studies indicate increased impulsivity in patients with opioid dependence (OD). However, few studies exclude concomitant drug use and consider depression as a comorbidity, both of which can bias results. Aim: We aimed to compare impulsivity in patients with OD enrolled in maintenance therapy (ICD code F11.22) and well-matched healthy controls taking psychopathological impairments into account. Furthermore, we compared the result to risky behavioral patterns in patients. Methods: This cross-sectional study included 50 patients with OD enrolled in either methadone or buprenorphine maintenance therapy and 50 healthy controls matched for gender, age, education, marital status, and premorbid intelligence. Abstinence from benzodiazepines, amphetamines, and cocaine was verified by urine analysis. We used the Barratt Impulsiveness Scale 11 (BIS-11), Beck’s Depression Inventory (BDI), the Symptom Checklist 90 Revised (SCL-90R), and the European version of the Addiction Severity Index (EuropASI). Results: Patients exhibited significantly worse impulse control than healthy individuals. We found no correlation between impulsiveness and reported risky behavior patterns but found a significant correlation between depressive symptoms and psychopathological impairment. Conclusions: Patients with OD showed a higher impulsivity than healthy individuals. Impulsivity could be a cause or a consequence of a substance use disorder; further research is warranted to explain this relationship. Impulsivity was associated with depression, an important confounder; future research needs to take this into account.
Neurobiological and Neurophysiological Mechanisms Underlying Nicotine Seeking and Smoking Relapse
Authors: Schmidt Heath D. , Rupprecht Laura E. , Addy Nii A.
Published: November 2018

Tobacco-related morbidity and mortality continue to be a significant public health concern. Unfortunately, current FDA-approved smoking cessation pharmacotherapies have limited efficacy and are associated with high rates of relapse. Therefore, a better understanding of the neurobiological and neurophysiological mechanisms that promote smoking relapse is needed to develop novel smoking cessation medications. Here, we review preclinical studies focused on identifying the neurotransmitter and neuromodulator systems that mediate nicotine relapse, often modeled in laboratory animals using the reinstatement paradigm, as well as the plasticity-dependent neurophysiological mechanisms that facilitate nicotine reinstatement. Particular emphasis is placed on how these neuroadaptations relate to smoking relapse in humans. We also highlight a number of important gaps in our understanding of the neural mechanisms underlying nicotine reinstatement and critical future directions, which may lead toward the development of novel, target pharmacotherapies for smoking cessation.
Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin
Authors: Sukkar Basma , Hauser Stefan , Pelzl Lisann , Hosseinzadeh Zohreh , Sahu Itishri , al-Maghout Tamer , Bhuyan Abdulla Al Mamun , Zacharopoulou Nefeli , Stournaras Christos , Schöls Ludger , Lang Florian
Published: November 2018

Background/Aims: The neurodegenerative disease Chorea-Acanthocytosis (ChAc) is caused by loss-of-function-mutations of the chorein-encoding gene VPS13A. In ChAc neurons transcript levels and protein abundance of Ca2+ release activated channel moiety (CRAC) Orai1 as well as its regulator STIM1/2 are decreased, resulting in blunted store operated Ca2+-entry (SOCE) and enhanced suicidal cell death. SOCE is up-regulated and cell death decreased by lithium. The effects of lithium are paralleled by upregulation of serum & glucocorticoid inducible kinase SGK1 and abrogated by pharmacological SGK1 inhibition. In other cell types SGK1 has been shown to be partially effective by upregulation of NFκB, a transcription factor stimulating the expression of Orai1 and STIM. The present study explored whether pharmacological inhibition of NFκB interferes with Orai1/STIM1/2 expression and SOCE and their upregulation by lithium in ChAc neurons. Methods: Cortical neurons were differentiated from induced pluripotent stem cells generated from fibroblasts of ChAc patients and healthy volunteers. Orai1 and STIM1 transcript levels and protein abundance were estimated from qRT-PCR and Western blotting, respectively, cytosolic Ca2+-activity ([Ca2+]i) from Fura-2-fluorescence, SOCE from increase of [Ca2+]i following Ca2+ re-addition after Ca2+-store depletion with sarco-endoplasmatic Ca2+-ATPase inhibitor thapsigargin (1µM), as well as CRAC current utilizing whole cell patch clamp recording. Results: Orai1 and STIM1 transcript levels and protein abundance as well as SOCE and CRAC current were significantly enhanced by lithium treatment (2 mM, 24 hours). These effects were reversed by NFκB inhibitor wogonin (50 µM). Conclusion: The stimulation of expression and function of Orai1/STIM1/2 by lithium in ChAc neurons are disrupted by pharmacological NFκB inhibition.
Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities
Authors: Hung Wen-Yueh , Chang Jer-Hwa , Cheng Yu , Chen Chi-Kuan , Chen Ji-Qing , Hua Kuo-Tai , Cheng Chao-Wen , Hsiao Michael , Chung Chi-Li , Lee Wei-Jiunn , Chien Ming-Hsien
Published: November 2018

Background/Aims: Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) therapy is a clinical option for non-small cell lung cancer (NSCLC) harboring activating EGFR mutations or for cancer with wild-type (WT) EGFR when chemotherapy has failed. MET receptor activation or MET gene amplification was reported to be a major mechanism of acquired resistance to EGFR-TKI therapy in NSCLC cells. Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine that was shown to suppress metastasis of hepatocellular carcinoma via inhibiting MET activity. Until now, the biological function responsible for LECT2’s action in human NSCLC remains unclear. Methods: LECT2-knockout (KO) mice and NOD/SCID/IL2rgnull (NSG) mice were respectively used to investigate the effects of LECT2 on the tumorigenicity and metastasis of murine (Lewis lung carcinoma, LLC) and human (HCC827) lung cancer cells. The effect of LECT2 on in vitro cell proliferation was evaluated, using MTS and colony formation assays. The effect of LECT2 on cell motility was evaluated using transwell migration and invasion assays. An enzyme-linked immunosorbent assay was performed to detect secreted LECT2 in plasma and media. Co-immunoprecipitation and Western blot assays were used to investigate the underlying mechanisms of LECT2 in NSCLC cells. Results: Compared to WT mice, mice with LECT2 deletion exhibited enhanced growth and metastasis of LLC cells, and survival times decreased in LLC-implanted mice. Overexpression of LECT2 in orthotopic human HCC827 xenografts in NSG mice resulted in significant inhibition of tumor growth and metastasis. In vitro, overexpression of LECT2 or treatment with a recombinant LECT2 protein impaired the colony-forming ability and motility of NSCLC cells (HCC827 and PC9) harboring high levels of activated EGFR and MET. Mechanistic investigations found that LECT2 bound to MET and EGFR to antagonize their activation and further suppress their common downstream pathways: phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase. Conclusion: EGFR-MET signaling is critical for aggressive behaviors of NSCLC and is recognized as a therapeutic target for NSCLC especially for patients with acquired resistance to EGFR-TKI therapy. Our findings demonstrate, for the first time, that LECT2 functions as a suppressor of the progression of NSCLC by targeting EGFR-MET signaling.
SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway
Authors: Li Fangwei , Wang Jian , Zhu Yanting , Liu Lu , Feng Wei , Shi Wenhua , Wang Qingting , Zhang Qianqian , Chai Limin , Li Manxiang
Published: November 2018

Background/Aims: The underlying molecular mechanisms involved in sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) mediation of platelet-derived growth factor (PDGF)-induced pulmonary arterial smooth muscle cell (PASMC) proliferation are still unclear, and the present study aims to address this issue. Methods: Small interfering RNA (siRNA) and microRNA inhibitor transfection was performed to block the expression of SphK1, bone morphogenetic protein receptor II (BMPRII) and microRNA-21 (miR-21). Gene expression levels of SphK1, BMPRII and inhibitor of DNA binding 1 (Id1) were detected by immunoblotting, miR-21 expression level was examined with qRT-PCR, and S1P production was measured by ELISA. Additionally, PASMC proliferation was determined by BrdU incorporation assay. Results: Our results indicated that PDGF increased the expression of SphK1 protein and S1P production, up-regulated miR-21 expression, reduced BMPRII and Id1 expression, and promoted PASMCs proliferation. Pre-silencing of SphK1 with siRNA reversed PDGF-induced S1P production, miR-21 up-regulation, BMPRII and Id1 down-regulation, as well as PASMC proliferation. Pre-inhibition of miR-21 also blocked BMPRII and Id1 down-regulation as well as PASMC proliferation caused by PDGF. Knockdown of BMPRII down-regulated Id1 expression in PASMCs. We further found that inhibition of PI3K/Akt and ERK signaling pathways, particularly ERK cascade, suppressed PDGF-induced above changes. Conclusion: Our study indicates that SphK1/S1P pathway plays an important role in PDGF-induced PASMC proliferation via miR-21/BMPRII/Id1 axis and targeting against SphK1/S1P axis might be a novel strategy in the prevention and treatment of pulmonary arterial hypertension (PAH).
Description of the pupa of Cnemida retusa (Fabricius, 1801) (Melolonthidae: Rutelinae)
Authors: Bento Matheus , Fuhrmann Juares , Bevilaqua Marcus Vinícius Oliveira
Published: November 2018

Pupae of chafer beetle (Melolonthidae) Cnemida retusa (Fabricius, 1801) (Rutelinae, Rutelini) were collected in October and November of 2017 in a decaying log at Reserva Florestal Adolpho Ducke, Manaus, Amazonas, Brazil, and are described and illustrated. The pupa description is the first to the genus and a key to known pupae of Rutelini is added.
Apresentação
Authors: Peixoto Fernanda Arêas , Giovanni Julia Ruiz Di
Published: November 2018

A abertura teórica da antropologia em relação a novos campos e domínios, notável nos últimos anos, vem acompanhada da releitura de textos e autores algo deixados de lado, em uma tentativa de reintroduzi-los nos debates recentes da disciplina...
Cartógrafo do corpo e do espírito
Authors: Glowczewski Barbara
Published: November 2018

O texto retoma a experiência da autora como aluna e orientanda de Michel de Certeau na Paris da década de 1970, tocada pela efervescência política do maio de 68. Apresentam-se reflexões sobre a importância do professor, tanto de suas análises teóricas, quanto de seu espírito livre e anticonvencional, bem como ponderações sobre sua formação e sobre o feitio de sua antropologia.
Fazer corpo como tomar a Bastilha
Authors: Giovanni Julia Ruiz Di
Published: November 2018

Este artigo retira da obra de Michel de Certeau indicações a respeito do lugar do corpo na ação política e nos processos de transformação social, colocando em foco a persistência nos escritos do autor de referências à corporalidade como dimensão fundamental da experiência mística, das operações de produção de conhecimento, da política das ruas de maio de 1968 e da inventividade da vida cotidiana. Destacamos assim a centralidade dessa dimensão na conceituação das práticas na perspectiva do autor e no uso que faz da função poética da linguagem como chave de reflexão sobre a ação social. Apontando a atualidade e possíveis usos contemporâneos dessas proposições, refletimos sobre algumas práticas de protesto dos estudantes secundaristas paulistas no ano de 2015, observando como tiram partido da mobilidade sempre irredutível das estruturas de saber e poder, fazendo uso, em ações disruptivas, de práticas corporais cotidianas supostamente normalizadas pela disciplina escolar.
O que fabrica o historiador quando faz história, hoje?
Authors: Cezar Temístocles
Published: November 2018

O problema geral deste ensaio é o de continuar perseguindo as apropriações historiográficas do tempo pelos antigos e modernos, tema que já venho tratando em pesquisas anteriores. Mais especificamente, pretendo realizar uma genealogia conceitual do topos popularizado por Cícero de que a história é mestra da vida: historia magistra vitae. A longa duração é necessária como condição à análise das diferentes recepções, percepções e retratações que a formulação adquiriu até chegar ao nosso presente. Nessa longa travessia procurarei mapear situações em que a historia magistra vitae converte-se nas figuras gêmeas da autoridade e da tradição e, finalmente, em crença. Essas duas figurações quando aliadas a indeterminações historiográficas do tempo e suas formas discursivas têm a capacidade de produzir explicações para o movimento histórico do passado e do presente, uma movimentação normalmente silenciosa, cujos efeitos geram maneiras distintas de entendimento da experiência do tempo vivido.
Relembrar Michel de Certeau
Authors: Peixoto Fernanda Arêas
Published: November 2018

Defendendo a importância de Michel de Certeau para a antropologia contemporânea, o artigo sugere afinidades da teoria das práticas do autor com certas formulações de Michael Herzfeld e Tim Ingold. Associada a essa análise, apresenta-se ainda uma reflexão de cunho pessoal sobre o modo como a leitura de Certeau auxiliou a redefinir as próprias pesquisas da autora.
Parentesco espiritual e afinidade potencial na América do Sul
Authors: Schiel Helena Moreira
Published: November 2018

No encontro colonial, duas formas de relação institucionalizada, as relações de compadrio cristão e as de afinidade potencial ameríndia, encontraram uma tal semelhança que puderam traduzir-se uma na outra. Partindo de uma leitura da sugestão de Salvatore D’Onofrio de um “átomo de parentesco espiritual” para explicar o compadrio, pretendo sugerir que as duas instituições evocam o mesmo tipo de armadura sociológica. Antes que a substituição do parentesco tradicional, acredito que o parentesco espiritual tenha uma relação de sobreposição e superação dos laços familiares. Avanço a hipótese de que esse tipo de relação institucionalizada estaria na base de toda relação política.
Compte-rendu: D’un monde à l’autre: D’un monde à l’autre – fragments d’une cosmologie brésilienne, de Agnès Clerc-Renaud
Authors: Ribeiro Cecília Rodrigues
Published: November 2018

Compte-rendu: D’un monde à l’autre: D’un monde à l’autre – fragments d’une cosmologie brésilienne, de Agnès Clerc-Renaud
Effect of different sources of non-fiber carbohydrate on ruminal pH and in vitro digestibility of tropical forage
Authors: Ferrari Viviane Borba , Diaz Angélica Patrícia Ordoñez , Cônsolo Nara Regina Brandão , De Sousa Rafael Teixeira , Rodriguez Frederich Diaz , Silva Luis Felipe Prada e
Published: November 2018

The present study aimed to evaluate non-fiber carbohydrates (NFC) in sugarcane-based diets on rumen pH, and forage digestibility, and to describe NFC degradation curves. The study consisted of two trials. For the first trial, three rumen cannulated steers, BW of 350 ± 15 kg (mean ± SE), were assigned in a 3×3 Latin Square (LS) design. They were fed diets containing finely-ground (0.9 mm average particle size) corn (GC), steam-rolled corn (SRC), or pelleted citrus pulp (PCP). Each period had 14 d, with the first 12 for adaptation. The 13th d was for serial measurement of rumen pH, and the14th for rumen fluid collection and in vitro incubation for DM and NDF digestibility (IVDMD and IVNDFD) of bermudagrass hay (Hay), corn (CS), and sugarcane (SS) silages. In the second trial, rumen fluid of a cannulated bull, fed corn silage and a regular concentrate, was collected for in vitro digestion of NFC for multiple time points. The incubation results were used to adjust the NFC degradation curves, and calculate lag-time, feed fractions, and degradation rate. Data from first trial was analyzed in a 3×3 LS. The model for the digestibility parameters included fixed effects of forage (Feed), diets with NFC (Diet), and their interaction (Feed × Diet), and random effect of animal and period. The model for rumen pH included fixed effect of diet, time as repeated measures, animal and period as random effects. The significance was considered at probability ≤ 5% (α = 0.05). The NFC degradation curves were adjusted using the PROC NLIN procedure from SAS, and equation parameters compared using confidence intervals. There was a Diet × Time interaction on rumen pH (P = 0.04), where SRC decreased pH compared to PCP and GC diets at the time 6 h, only. There was no Feed × Diet interaction effect (P > 0.05) for any digestibility parameter. There was a Feed effect on both IVDMD and IVNDFD, either after 30 or 48 h incubation (P < 0.01). The CS had the greatest IVDMD, followed by SS and Hay, after 30 and 48 h of incubation. The CS had the greatest IVNDFD after 30 h, compared to SS and Hay. However, for IVNDFD after 48 h, CS presented the greatest mean, followed by SS and Hay. The rumen fluid from animals fed SRC decreased both IVDMD and IVNDFD (P < 0.05) of all roughages after 48 h. Results from the second trial showed that the PCP had lower Lag Time, B fraction and greater kd compared to both corn sources, and SRC had greater kd than GC. In conclusion, the SRC diet decreased rumen pH 6 h after feeding and, consequently, decreased fiber digestibility of the tropical forage sources evaluated. Although the PCP had lower lag time, and faster rate of degradation of B fraction, it did not negatively affect rumen pH or fiber digestibility of forage.
Feline chronic gingivostomatitis with calicivirus infection
Authors: Da Silva Aline Silvestrini , Hertel Fernanda Campos , Lotério Mayara Pereira , Cota Jéssica Miranda , Rodrigues Bruna Giannakopoulos , Santos Marcus Rebouças , Reis Emily Correna Carlo
Published: November 2018

Feline chronic gingivostomatitis (FCGS) is an oral inflammatory condition that frequently affects felines. Its etiology is not well defined, but several viral agents are thought to be involved. Several therapeutic protocols have been described, yet treatment response is often variable, and the therapeutic success is transient with an unpredictable duration. Therefore, the therapeutic strategy needs to be tailored for each patient. This work relates a case characterized by viral involvement in its etiopathogenesis providing an alternative to the most widely-used methods that so often frustrate both veterinary doctors and pet owners.
Turkey meat quality (Meleagris gallopavo) submitted to different ventilation systems during fattening
Authors: Marcon Diego Francisco , Crecencio Regiane Boaretto , De Castro Tanize Angonesi , Budel Leidiane Josi , Ramirez-Fernandez Francisco Javier , Starikoff Karina Ramirez
Published: November 2018

The present investigation evaluated the quality of turkey meat produced in two production systems, according to the following parameters: water loss in cooking, drip water loss, texture (shear strength), pH, color, humidity, protein, ashes and lipids. A total of 200 turkey breast samples of 500 g, separated by a batch of 20 samples, from ten aviaries from Santa Catarina, Brazil, were used: five from breeding with a traditional ventilation system and five with a mechanical ventilation system. Samples were obtained after slaughter and frozen at -15°C for 30 days. The results were submitted to variance analysis and the Tukey test. Significant differences were found only in the analysis of drip water loss. The birds of the traditional ventilation system presented 14.26% loss of water drip, while those of the ventilation exhaust system presented a loss of 19.21%. There were no differences in the chemical composition of poultry meat in relation to the production systems.
Construção, estratégias e práticas: análise de dois cartazes de “Meia-noite em Paris”
Authors: Coutinho Mariana De Souza
Published: November 2018

Este trabalho analisa dois cartazes de cinema do filme Meia-Noite em Paris (2011), de Woody Allen. Levamos em conta o conteúdo do filme e a prática que envolve os cartazes de cinema para entender quais são as diferentes estratégias empregadas nos textos analisados, que produzem enunciações bem diferentes tanto no plano do conteúdo quanto no plano da expressão. Tomamos por base o conceito de prática semiótica de Fontanille (2005), descrevendo aquela que envolve os cartazes de cinema. Se, nessa prática, o cartaz objetiva atingir o mesmo perfil de enunciatário do filme que ele apresenta, que estratégias plásticas serão postas em questão para construir esse texto em relação ao filme? Como essas estratégias se relacionam com os gêneros cinematográficos e quais são as reiterações em cartazes que passam a remeter a certo gênero? Os cartazes de Meia-Noite em Paris utilizam essas estratégias ligadas ao gênero em que ele se enquadra? Nossa análise se baseia nas ferramentas da semiótica francesa, especialmente da semiótica plástica, como as categorias cromática, eidética e topológica (Floch, 1985), e o estabelecimento de relações semissimbólicas para responder a essas perguntas e verificar se há identidade entre cartaz e filme e se os perfis de enunciatário de ambos batem.
O patrimônio de Mário de Andrade
Authors: Santos Cecilia Rodrigues dos
Published: November 2018

O objetivo deste trabalho é refletir sobre a concepção de patrimônio de Mário de Andrade, na sua relação com as ideias de etnografia e folclore em debate nos anos 1930, a partir da elaboração do Anteprojeto para a criação do Serviço do Patrimônio Histórico e Artístico Nacional.
O patrimônio arquitetônico de Sorocaba visto através do acervo fotográfico do IPHAN
Authors: Cunha Claudia Dos Reis e
Published: November 2018

Este artigo apresenta parte dos resultados da pesquisa “O patrimônio cultural da cidade de Sorocaba: análise de uma trajetória”, desenvolvida na Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo, no que se refere especificamente aos procedimentos de inventário e consequente atribuição de valor aos bens culturais da cidade de Sorocaba-SP empreendidos pelo Instituto do Patrimônio Histórico e Artístico Nacional (Iphan), tendo como principal base documental utilizada o acervo fotográfico da 9ª Superintendência Regional da instituição, em São Paulo. Dessa forma, procura-se problematizar as ações do órgão federal de preservação no que se refere ao município de Sorocaba-SP, os critérios e procedimentos adotados, privilegiando o papel que o documento fotográfico teve na construção de uma narrativa visual daquilo que era – ou não – importante como memória a ser transmitida às gerações posteriores.
Mário de Andrade e Lúcio Costa no número inaugural da Revista do SPHAN
Authors: Pinheiro Maria Lúcia Bressan
Published: November 2018

O presente artigo pretende analisar a contribuição de Mário de Andrade e de Lúcio Costa – dois colaboradores de primeira hora, e de primeira grandeza, do Instituto do Patrimônio Histórico e Artístico Nacional (Iphan), então denominado Serviço do Patrimônio Histórico e Artístico Nacional  (SPHAN) – no número inaugural da Revista do SPHAN. Trata-se dos artigos A capela do Sítio Santo Antônio, de Mário de Andrade, e Documentação necessária, escrito por Lúcio Costa, considerados emblemáticos de um dos aspectos mais relevantes da atuação pioneira do Iphan: o estabelecimento de um campo do conhecimento voltado à história da arquitetura brasileira. A contribuição desses autores será apresentada no contexto de criação do novo Serviço, desde seu envolvimento prévio com a problemática da preservação e documentação da arquitetura brasileira, na década de 1920, até seu efetivo engajamento nas atividades do novo órgão.
Minha vida em cor-de-rosa
Authors: Oliveira Megg Rayara Gomes de
Published: November 2018

Neste artigo discuto a transexualidade feminina na infância. Utilizo como objeto de análise o filme Minha vida em cor-de-rosa (Bélgica, França, Reino Unido, 1997) e o documentário Meu eu secreto (Estados Unidos da América, 2007), procurando fazer uma relação com o debate atual sobre ideologia de gênero. O interesse, então, está concentrado nas ideias centrais das duas produções, ou seja: a transição do gênero masculino para o feminino, a patologização e despatologização das identidades trans, a relação entre sexo anatômico e identidade de gênero, violência simbólica, cis heteronormatividade e a supervalorização do adulto. Para fazer esse debate recorro às reflexões de John Thompson (2009) sobre comunicação de massa e violência simbólica, os estudos de gênero e sobre diversidade sexual, bem como os estudos pós-estruturalistas, especialmente a obra de Michel Foucault.

Palavras-chave: Identidade de gênero, Transexualidade, Infância, Violência simbólica, Sociedade.
Meu corpo é a minha luta diária
Authors: Ferraz Mirela Ferreira
Published: November 2018

Este artigo tem como objetivo analisar a performance Espaço do silêncio, de Nina Caetano, a fim de discutir a dimensão crítica do trabalho no que se refere, sobretudo, à violência contra a mulher. Pretende-se analisar como a ação performativa realizada na rua redimensiona as fronteiras entre artista e público, tornando-se um dispositivo político de combate contra a violência em questão.

Palavras-chave: Performance de rua, Violência de gênero, Violência contra a mulher.
Feminino abjeto
Authors: Leite Janaina Fontes
Published: November 2018

Este texto trata do processo de criação do experimento Feminino Abjeto, sob a luz de seu principal conceito norteador, a abjeção, tal qual proposto pela filósofa Julia Kristeva. Segundo a autora, o conceito remonta às tentativas primeiras de nos separarmos do corpo materno como processo de individuação. Processo nunca inteiramente concluído, a abjeção e o território da mãe permanecem como uma espécie de margem do real. É a partir dessa ideia que Feminino abjeto buscou na mãe, ou na tensão mãe-filha, um caminho para problematizar as representações do feminino hoje.

Palavras-chave: Abjeção, Feminino, Processo de criação, Teatro contemporâneo.