bluuebunny/crossref_metadata_2025 huggingface dataset:
Carotenoids, Phenolic Compounds and Tocopherols Contribute to the Antioxidative Properties of Some Microalgae Species Grown on Industrial Wastewater
Authors: Safafar Hamed , Van Wagenen Jonathan , Møller Per , Jacobsen Charlotte
Published: December 2015

This study aimed at investigating the potential of microalgae species grown on industrial waste water as a new source of natural antioxidants. Six microalgae from different classes, including Phaeodactylum sp. (Bacillariophyceae), Nannochloropsis sp. (Eustigmatophyceae), Chlorella sp., Dunaniella sp., and Desmodesmus sp. (Chlorophyta), were screened for their antioxidant properties using different in vitro assays. Natural antioxidants, including pigments, phenolics, and tocopherols, were measured in methanolic extracts of microalgae biomass. Highest and lowest concentrations of pigments, phenolic compounds, and tocopherols were found in Desmodesmus sp. and Phaeodactylum tricornuotom microalgae species, respectively. The results of each assay were correlated to the content of natural antioxidants in microalgae biomass. Phenolic compounds were found as major contributors to the antioxidant activity in all antioxidant tests while carotenoids were found to contribute to the 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging activity, ferrous reduction power (FRAP), and ABTS-radical scavenging capacity activity. Desmodesmus sp. biomass represented a potentially rich source of natural antioxidants, such as carotenoids (lutein), tocopherols, and phenolic compounds when cultivated on industrial waste water as the main nutrient source.
A Simple Up-Scalable Thermal Treatment Method for Synthesis of ZnO Nanoparticles
Authors: Lee Phin , Saion Elias , Al-Hada Naif , Soltani Nayereh
Published: December 2015

A simple thermal treatment method, utilizing only zinc nitrate, polyvinyl pyrrolidone (PVP), and deionized water, was used to synthesize ZnO nanoparticles, and their characteristics were investigated by various techniques. The TGA measurement demonstrated that the bulk of the capping agent PVP can be removed at temperatures higher than 500 °C and is consistent with the absence of the majority of PVP absorption peaks in the FT-IR spectra. The formation of almost pure ZnO nanoparticles was established by the presence of single absorption peak in the FT-IR spectra due to being only Zn–O bonds at calcination temperatures of 500 °C and above. The TEM images revealed that the nanoparticles have a spherical shape and the particle size increased from 60.1–83.1 nm with an increase in calcination temperatures from 500–600 °C. The XRD diffraction patterns indicated that the particles are of a wurzite lattice structure. The optical properties were determined by UV-Vis spectrophotometer, and it was found that the band gap of ZnO nanoparticles decreased from 3.249–3.239 eV with an increase in calcination temperature from 500–600 °C.
Liquid Gradient Refractive Index Microlens for Dynamically Adjusting the Beam Focusing
Authors: Le Zichun , Sun Yunli , Du Ying
Published: December 2015

An in-plane liquid gradient index (L-GRIN) microlens is designed for dynamically adjusting the beam focusing. The ethylene glycol solution (core liquid) withde-ionized (DI) water (cladding liquid) is co-injected into the lens chamber to form a gradient refractive index profile. The influences of the diffusion coefficient, mass fraction of ethylene glycol and flow rate of liquids on the refractive index profile of L-GRIN microlens are analyzed, and the finite element method and ray tracing method are used to simulate the convection-diffusion process and beam focusing process, which is helpful for the prediction of focusing effects and manipulation of the device. It is found that not only the focal length but the focal spot of the output beam can be adjusted by the diffusion coefficient, mass fraction and flow rate of liquids. The focal length of the microlens varies from 942 to 11 μm when the mass fraction of the ethylene glycol solution varies from 0.05 to 0.4, and the focal length changes from 127.1 to 8 μm by varying the flow rate of the core liquid from 0.5 × 103 to 5 × 103 pL/s when there is no slip between the core and cladding inlet. The multiple adjustable microlens with a simple planar microfluidic structure can be used in integrated optics and lab-on-chip systems.
Mining the Dynamic Genome: A Method for Identifying Multiple Disease Signatures Using Quantitative RNA Expression Analysis of a Single Blood Sample
Authors: Chao Samuel , Cheng Changming , Liew Choong-Chin
Published: December 2015

Background: Blood has advantages over tissue samples as a diagnostic tool, and blood mRNA transcriptomics is an exciting research field. To realize the full potential of blood transcriptomic investigations requires improved methods for gene expression measurement and data interpretation able to detect biological signatures within the “noisy” variability of whole blood. Methods: We demonstrate collection tube bias compensation during the process of identifying a liver cancer-specific gene signature. The candidate probe set list of liver cancer was filtered, based on previous repeatability performance obtained from technical replicates. We built a prediction model using differential pairs to reduce the impact of confounding factors. We compared prediction performance on an independent test set against prediction on an alternative model derived by Weka. The method was applied to an independent set of 157 blood samples collected in PAXgene tubes. Results: The model discriminated liver cancer equally well in both EDTA and PAXgene collected samples, whereas the Weka-derived model (using default settings) was not able to compensate for collection tube bias. Cross-validation results show our procedure predicted membership of each sample within the disease groups and healthy controls. Conclusion: Our versatile method for blood transcriptomic investigation overcomes several limitations hampering research in blood-based gene tests.
Synthesis and Structure of a Sodium Complex of an Aromatic β-Diketone and Pyrazolylpyridine
Authors: Coelho Ana , Almeida Paz Filipe , Klinowski Jacek , Pillinger Martyn , Gonçalves Isabel
Published: December 2015

Reaction of NaH with a THF solution of Eu(BTA)3(pypzH) [BTA = 1-benzoyl-3,3,3-trifluoroacetonate, pypzH = 2-(3-pyrazolyl)pyridine] leads to the formation of theeuropium-free tetrasodium complex [Na4(pypzH)2(μ4-BTA)2(μ2-BTA)2]. Single-crystal X-ray diffraction studies revealed the presence of a centrosymmetric Na hybrid tetramer,which fully occupies the contents of the triclinic unit cell. The crystal structure containstwo individual Na cations, Na(1) and Na(2), which have highly irregular {NaN2O3} and{NaO6} local coordination environments, respectively. One of the key features is thepresence of a central {Na4O6} core, which is unprecedented for Na . Externally to this{Na4O6} cluster pyrazolylpyridine organic molecules are N,N-chelated to Na(1). Eventhough all of the organic residues contain aromatic rings, the crystal packing of individualcentrosymmetric tetrasodium [Na4(pypzH)2(μ4-BTA)2(μ2-BTA)2] molecular moieties isessentially driven through geometrical aspects combined with weak C–H···π interactions,rather than the expected a priori π-π interactions. The material also contains classicalstrong hydrogen bonds, even though these do not directly contribute to the packingdriving forces.
Novel Penicillin-Type Analogues Bearing a Variable Substituted 2-Azetidinone Ring at Position 6: Synthesis and Biological Evaluation
Authors: De Rosa Margherita , Vigliotta Giovanni , Palma Giuseppe , Saturnino Carmela , Soriente Annunziata
Published: December 2015

The synthesis and the biological activity of novel semi-synthetic β-lactam compounds containing an azetidinone moiety joined to the amino-nitrogen of the (+)-6-aminopenicillanic acid (6-APA) as new antibacterial agents is reported. The synthesized compounds were screened for their in vitro antimicrobial activity against a panel of Gram positive and Gram negative pathogens and environmental bacteria. Tested compounds displayed good antimicrobial activity against all tested Gram positive bacteria and for Staphylococcus aureus and Staphylococcus epidermidis antimicrobial activity resulted higher than that of the reference antibiotic. Additionally, in vitro cytotoxic screening was also carried out indicating that the compounds do not cause a cell vitality reduction effective at concentration next to and above those shown to be antimicrobial.
Safety Evaluation, in Vitro and in Vivo Antioxidant Activity of the Flavonoid-Rich Extract from Maydis stigma
Authors: Peng Ke-Zheng , Yang Xiudong , Zhou Hong-Li , Pan Shu-Xia
Published: December 2015

This study aimed to assess the acute toxicity and safety of flavonoid-rich extract from Maydis stigma (FMS) in mice. The in vitro antioxidant activity of FMS was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azinobis-(3-ethyl-benzthiazoline-6-sulphonate) (ABTS) scavenging assays. Furthermore, the in vivo antioxidant of FMS against ethanol-induced oxidative damage in mice was determined by analysis of the serum total superoxide dismutase (T-SOD) activity, malondialdehyde (MDA) content, liver tissue glutathione (GSH) content, and protein carbonyl (PC) content in liver tissue. The oral administration of FMS at doses of 30 g/kg did not cause death in mice, and there were no significant biologically adverse effects in mice. These results indicated that the median lethal dose (LD50) is higher than this dose. The IC50 values of FMS for the DPPH and ABTS scavenging activity were 50.73 and 0.23 mg/mL, respectively. Meanwhile, FMS could significantly enhance T-SOD activity, reduce MDA content in the serum, increase GSH content, and decrease PC content in the liver tissue at the tested doses (25, 50, 100, 200 mg/kg·day). These results indicate that FMS can be generally regarded as safe and used potentially as a bioactive source of natural antioxidants.
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment
Authors: Korabecny Jan , Andrs Martin , Nepovimova Eugenie , Dolezal Rafael , Babkova Katerina , Horova Anna , Malinak David , Mezeiova Eva , Gorecki Lukas , Sepsova Vendula , Hrabinova Martina , Soukup Ondrej , Jun Daniel , Kuca Kamil
Published: December 2015

Alzheimer’s disease (AD) is a debilitating progressive neurodegenerative disorder that ultimately leads to the patient’s death. Despite the fact that novel pharmacological approaches endeavoring to block the neurodegenerative process are still emerging, none of them have reached use in clinical practice yet. Thus, palliative treatment represented by acetylcholinesterase inhibitors (AChEIs) and memantine are still the only therapeutics used. Following the multi-target directed ligands (MTDLs) strategy, herein we describe the synthesis, biological evaluation and docking studies for novel 7-methoxytacrine-p-anisidine hybrids designed to purposely target both cholinesterases and the amyloid cascade. Indeed, the novel derivatives proved to be effective non-specific cholinesterase inhibitors showing non-competitive AChE inhibition patterns. This compounds’ behavior was confirmed in the subsequent molecular modeling studies.
Herb-Drug Pharmacokinetic Interactions: Transport and Metabolism of Indinavir in the Presence of Selected Herbal Products
Authors: Calitz Carlemi , Gouws Chrisna , Viljoen Joe , Steenekamp Jan , Wiesner Lubbe , Abay Efrem , Hamman Josias
Published: December 2015

Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions exist between selected commercially available herbal products (i.e., Linctagon Forte®, Viral Choice® and Canova®) and indinavir in terms of in vitro transport and metabolism. Bi-directional transport of indinavir was evaluated across Caco-2 cell monolayers in the presence and absence of the selected herbal products and verapamil (positive control). Metabolism of indinavir was determined in LS180 cells in the presence and absence of the selected herbal products as well as ketoconazole (positive control). The secretory transport of indinavir increased in a concentration dependent way in the presence of Linctagon Forte® and Viral Choice® when compared to that of indinavir alone. Canova® only slightly affected the efflux of indinavir compared to that of the control group. There was a pronounced inhibition of the metabolism of indinavir in LS180 cells over the entire concentration range for all the herbal products investigated in this study. These in vitro pharmacokinetic interactions indicate the selected herbal products may affect indinavir’s bioavailability, but the clinical significance needs to be confirmed with in vivo studies before final conclusions can be made.
Study of the Relationships between the Structure, Lipophilicity and Biological Activity of Some Thiazolyl-carbonyl-thiosemicarbazides and Thiazolyl-azoles
Authors: Tamaian Radu , Moţ Augustin , Silaghi-Dumitrescu Radu , Ionuţ Ioana , Stana Anca , Oniga Ovidiu , Nastasă Cristina , Benedec Daniela , Tiperciuc Brînduşa
Published: December 2015

Lipophilicity, as one of the most important physicochemical parameters of bioactive molecules, was investigated for twenty-two thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles. The determination was carried out by reversed-phase thin-layer chromatography, using a binary isopropanol-water mobile phase. Chromatographically obtained lipophilicity parameters were correlated with calculated log P and log D and with some biological parameters, determined in order to evaluate the anti-inflammatory and antioxidant potential of the investigated compounds, by using principal component analysis (PCA). The PCA grouped the compounds based on the nature of their substituents (X, R and Y), indicating that their nature, electronic effects and molar volumes influence the lipophilicity parameters and their anti-inflammatory and antioxidant effects. Also, the results of the PCA analysis applied on all the experimental and computed parameters show that the best anti-inflammatory and antioxidant compounds were correlated with medium values of the lipophilicity parameters. On the other hand, the knowledge of the grouping patterns of the tested variables allows the reduction of the number of parameters, determined in order to establish the biological activity.
Studies on the Low-Temp Oxidation of Coal Containing Organic Sulfur and the Corresponding Model Compounds
Authors: Zhang Lanjun , Li Zenghua , Li Jinhu , Zhou Yinbo , Yang Yongliang , Tang Yibo
Published: December 2015

This paper selects two typical compounds containing organic sulfur as model compounds. Then, by analyzing the chromatograms of gaseous low-temp oxidation products and GC/MS of the extractable matter of the oxidation residue, we summarizing the mechanism of low-temp sulfur model compound oxidation. The results show that between 30 °C to 80 °C, the interaction between diphenyl sulfide and oxygen is mainly one of physical adsorption. After 80 °C, chemical adsorption and chemical reactions begin. The main reaction mechanism in the low-temp oxidation of the model compound diphenyl sulfide is diphenyl sulfide generates diphenyl sulfoxide, and then this sulfoxide is further oxidized to diphenyl sulphone. A small amount of free radicals is generated in the process. The model compound cysteine behaves differently from diphenyl sulfide. The main reaction low-temp oxidation mechanism involves the thiol being oxidized into a disulphide and finally evolving to sulfonic acid, along with SO2 being released at 130 °C and also a small amount of free radicals. We also conducted an experiment on coal from Xingcheng using X-ray photoelectron spectroscopy (XPS). The results show that the major forms of organic sulfur in the original coal sample are thiophene and sulfone. Therefore, it can be inferred that there is none or little mercaptan and thiophenol in the original coal. After low-temp oxidation, the form of organic sulfur changes. The sulfide sulfur is oxidized to the sulfoxide, and then the sulfoxide is further oxidized to a sulfone, and these steps can be easily carried out under experimental conditions. What’s more, the results illustrate that oxidation promotes sulfur element enrichment on the surface of coal.
Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells
Authors: Lau Wai , Goh Bey , Kadir Habsah , Shu-Chien Alexander , Tengku Muhammad Tengku
Published: December 2015

Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPARγ ligand activity. They were corresponded to PPARγ-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPARγ. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter.
Understanding Critical Quality Attributes for Nanocrystals from Preparation to Delivery
Authors: Peltonen Leena , Strachan Clare
Published: December 2015

Poor solubility of active pharmaceutical ingredients (APIs) is a great challenge for the pharmaceutical industry and, hence, drug nanocrystals are widely studied as one solution to overcome these solubility problems. Drug nanocrystals have comparatively simple structures which make them attractive for the formulation for poorly soluble drugs, and their capability to improve the dissolution in vitro is easily demonstrated, but turning the in vitro superior properties of nanocrystals to success in vivo, is often demanding: controlled (including enhanced) drug dissolution followed by successful permeation is not guaranteed, if for example, the dissolved drug precipitates before it is absorbed. In this review critical quality attributes related to nanocrystal formulations from production to final product performance in vivo are considered. Many important parameters exist, but here physical stability (aggregation tendency and solid state form), solubility properties influencing dissolution and supersaturation, excipient use to promote the maintenance of supersaturation, and finally the fate of nanocrystals in vivo are the main subjects of our focus.
Use of Modified Phenolic Thyme Extracts (Thymus vulgaris) with Reduced Polyphenol Oxidase Substrates as Anthocyanin Color and Stability Enhancing Agents
Authors: Aguilar Oscar , Hernández-Brenes Carmen
Published: December 2015

Residual enzymatic activity in certain foods, particularly of polyphenoloxidase (PPO), is responsible for the majority of anthocyanin degradation in food systems, causing also parallel losses of other relevant nutrients. The present work explored the feasibility of modifying phenolic profiles of thyme extracts, by use of chromatographic resins, to obtain phenolic extracts capable of enhancing anthocyanin colour and stability in the presence of PPO activity. Results indicated that pretreatment of thyme extracts with strong-anion exchange resins (SAE) enhanced their copigmentation abilities with strawberry juice anthocyanins. Phenolic chromatographic profiles, by HPLC-PDA, also demonstrated that thyme extracts subjected to SAE treatments had significantly lower concentrations of certain phenolic compounds, but extracts retained their colour enhancing and anthocyanin stabilization capacities though copigmentation. Additional testing also indicated that SAE modified extract had a lower ability (73% decrease) to serve as PPO substrate, when compared to the unmodified extract. Phenolic profile modification process, reported herein, could be potentially used to manufacture modified anthocyanin-copigmentation food and cosmetic additives for colour-stabilizing applications with lower secondary degradation reactions in matrixes that contain PPO activity.
A Comprehensive Study of the Use of Cu(I)/4,4’-Dicarboxy-2,2’-biquinoline Complexes to Measure the Total Reducing Capacity: Application in Herbal Extracts
Authors: Manoel Hariane , Moya Horacio
Published: December 2015

A method for the determination of total reducing capacity (TRC) based on the reduction of Cu(II) to Cu(I) by antioxidants in a buffered solution (pH 7.0) containing 4,4′-dicarboxy-2,2′-biquinoline acid (BCA) was developed. Absorbance values at 558 nm characteristic of the Cu(I)/BCA complexes formed were used to determine the TRC of aqueous extracts of twelve Brazilian plants. The TRC values obtained with the suggested method correlated well with values obtained using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method (r2 = 0.959). They were also compared with the total polyphenol content (using the Folin-Ciocalteu reagent) and the good agreement (r2 = 0.919) indicates that the polyphenols should be responsible for this reducing capacity. The method proposed here (and successfully applied in plant extracts) can be used to measure the TRC of aqueous samples derived from other plants (e.g., teas, juices, beers and wines) and even in biological samples (e.g., serum, urine and follicular fluid). To achieve a structure-activity relationship of the proposed reaction, the reduction capability of 25 standard antioxidants (phenolic derivatives, flavonoids, stilbenoids, vitamins, etc.) was individually evaluated and the apparent molar absorptivity values (at 558 nm) obtained were compared and discussed.
The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi
Authors: Pereira Wagner , De Souza Vasconcellos Raphael , Mariotini-Moura Christiane , Saar Gomes Rodrigo , Firmino Rafaela , Da Silva Adalberto , Silva Júnior Abelardo , Bressan Gustavo , Almeida Márcia , Crocco Afonso Luís , Teixeira Róbson , Lopes Rangel Fietto Juliana
Published: December 2015

Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B. However, these pharmaceuticals are either too toxic or expensive for routine use in developing countries. These facts call for safer, cheaper, and more effective new antileishmanial drugs. In this investigation, we describe the results of the assessment of the activities of a series of isobenzofuran-1(3H)-ones (phtalides) against Leishmania (Leishmania) infantum chagasi, which is the main causative agent of visceral leishmaniasis in the New World. The compounds were tested at concentrations of 100, 75, 50, 25 and 6.25 µM over 24, 48, and 72 h. After 48 h of treatment at the 100 µM concentration, compounds 7 and 8 decreased parasite viability to 4% and 6%, respectively. The concentration that gives half-maximal responses (LC50) for the antileishmanial activities of compounds 7 and 8 against promastigotes after 24 h were 60.48 and 65.93 µM, respectively. Additionally, compounds 7 and 8 significantly reduced parasite infection in macrophages.
Magnetic Nanoparticles Cross the Blood-Brain Barrier: When Physics Rises to a Challenge
Authors: Busquets Maria , Espargaró Alba , Sabaté Raimon , Estelrich Joan
Published: December 2015

The blood-brain barrier is a physical and physiological barrier that protects the brain from toxic substances within the bloodstream and helps maintain brain homeostasis. It also represents the main obstacle in the treatment of many diseases of the central nervous system. Among the different approaches employed to overcome this barrier, the use of nanoparticles as a tool to enhance delivery of therapeutic molecules to the brain is particularly promising. There is special interest in the use of magnetic nanoparticles, as their physical characteristics endow them with additional potentially useful properties. Following systemic administration, a magnetic field applied externally can mediate the capacity of magnetic nanoparticles to permeate the blood-brain barrier. Meanwhile, thermal energy released by magnetic nanoparticles under the influence of radiofrequency radiation can modulate blood-brain barrier integrity, increasing its permeability. In this review, we present the strategies that use magnetic nanoparticles, specifically iron oxide nanoparticles, to enhance drug delivery to the brain.
Naringin Reverses Hepatocyte Apoptosis and Oxidative Stress Associated with HIV-1 Nucleotide Reverse Transcriptase Inhibitors-Induced Metabolic Complications
Authors: Adebiyi Oluwafeyisetan , Adebiyi Olubunmi , Owira Peter
Published: December 2015

Nucleoside Reverse Transcriptase Inhibitors (NRTIs) have not only improved therapeutic outcomes in the treatment of HIV infection but have also led to an increase in associated metabolic complications of NRTIs. Naringin’s effects in mitigating NRTI-induced complications were investigated in this study. Wistar rats, randomly allotted into seven groups (n = 7) were orally treated daily for 56 days with 100 mg/kg zidovudine (AZT) (groups I, II III), 50 mg/kg stavudine (d4T) (groups IV, V, VI) and 3 mL/kg of distilled water (group VII). Additionally, rats in groups II and V were similarly treated with 50 mg/kg naringin, while groups III and VI were treated with 45 mg/kg vitamin E. AZT or d4T treatment significantly reduced body weight and plasma high density lipoprotein concentrations but increased liver weights, plasma triglycerides and total cholesterol compared to controls, respectively. Furthermore, AZT or d4T treatment significantly increased oxidative stress, adiposity index and expression of Bax protein, but reduced Bcl-2 protein expression compared to controls, respectively. However, either naringin or vitamin E significantly mitigated AZT- or d4T-induced weight loss, dyslipidemia, oxidative stress and hepatocyte apoptosis compared to AZT- or d4T-only treated rats. Our results suggest that naringin reverses metabolic complications associated with NRTIs by ameliorating oxidative stress and apoptosis. This implies that naringin supplements could mitigate lipodystrophy and dyslipidemia associated with NRTI therapy.
Health Literacy in Obstetric Patients: A Pharmacist’s Experience with The Newest Vital Sign
Authors: Ragland Denise , Payakachat Nalin
Published: December 2015

Health literacy can greatly impact patients’ self-management of medical conditions and adherence to treatment recommendations. This study aimed to assess the health literacy of obstetric patients at a university-based women’s clinic using the Newest Vital Sign (NVS). A clinical pharmacist or student pharmacist utilized the instrument to interview women during a routine clinic visit. This project is a cross-sectional, retrospective study using the de-identified survey data. Descriptive statistics were used to provide a summary of the NVS scores in this population. The average age of the 140 participants was 27 years (SD = 6) with the range from 16 to 49 years old. The majority (78%) of the patients was ≤ 30 years old; 50% were white and 39% were black. The average NVS score was 3 (SD = 2.2). 49% had scores ≤ 3 which indicates limited literacy. This pilot study yielded preliminary data for future investigations of health literacy in this population while identifying a potential role for pharmacists. Due to its ease of use and quick administration, it is feasible to use the NVS instrument to routinely screen health literacy in an obstetric clinic setting.
A Comparison of the Performance of Bias-Corrected RSMs and RFMs for the Geo-Positioning of High-Resolution Satellite Stereo Imagery
Authors: Hong Zhonghua , Tong Xiaohua , Liu Shijie , Chen Peng , Xie Huan , Jin Yanmin
Published: December 2015

High-resolution stereo satellite imagery is widely used in environmental monitoring, topographic mapping, and urban three-dimensional (3D) reconstruction. However, a critical issue in these applications using high-resolution stereo satellite imagery is to improve the accuracy of point geo-positioning. This paper presents a framework for comparison of the performance of the three-dimensional (3D) geo-positioning of the bias-corrected Rigorous Sensor Models (RSMs) and rational function models (RFMs) with respect to the high-resolution QuickBird stereo images in three spaces (i.e., orbital space, image space and object space). The compared models include a bias-corrected RSM in the orbital space, a bias-corrected RSM and RFM in the image space, and a bias-corrected RSM and RFM in the object space. In the comparison, the RSMs and RFMs use the vendor-provided orbit data and Rational Polynomial Coefficients (RPCs), respectively. The experimental results indicated that, (1) these five bias-corrected models can provide a sub-pixel geo-positioning accuracy. With the zero-order polynomial correction model in the orbital space and a minimum of three Ground Control Points (GCPs), the accuracy based on RPCs better than 0.8 m in horizontal direction and 1.3 m in vertical direction. With an increase in the number of GCPs, or in the order of correction models, the regenerated orbital parameters achieve a slight improved positioning accuracy of 0.5 m in horizontal direction and 0.8 m in vertical direction with 25 GCPs, which indicates that the low-order correction model in the orbital space can accurately model the effects of ephemeris and attitude errors; (2) the performances of bias-corrected RSM and RFM in image space are rather similar. However, the bias-corrected RSM and RFM in image space achieve a better accuracy than the bias-corrected RSM and RFM in object space, with the same configuration of GCPs.
Radiometric Block Adjustment for Multi-Strip Airborne Waveform Lidar Data
Authors: Teo Tee-Ann , Wu Hsien-Ming
Published: December 2015

The airborne lidar system has been shown to be an effective and reliable method for spatial data collection. Lidar records the coordinates of point and intensity, dependent on range, incident angle, reflectivity of object, atmospheric condition, and several external factors. To fully utilize the intensity of a lidar system, several researchers have proposed correction models from lidar equations. The radiometric correction models are divided into physically-oriented models and data-oriented models. The lidar acquisition often contains multiple flight lines, and the radiation energy of each flight line can be calibrated independently by calibration coefficient. However, the calibrated radiances in the overlapped area have slightly different measurements. These parameters should be implicitly taken into account if calibrating radiances back to reflectance using known calibration targets. This study used a single-strip physically-oriented model to obtain a backscattering coefficient and a data-oriented model to obtain corrected intensity. We then selected homogeneous tie regions in the overlapped areas, and the differences between strips were compensated by gain and offset parameters in multi-strip radiometric block adjustment. The results were evaluated by the radiometric differences. Nine strips were acquired by Rigel Q680i system, and the experimental results showed that the delta intensity and delta backscattering coefficient of tie regions were improved up to 60% after multi-strip block adjustment.
On the Role of Land Surface Temperature as Proxy of Soil Moisture Status for Drought Monitoring in Europe
Authors: Cammalleri Carmelo , Vogt Jürgen
Published: December 2015

Remotely sensed Land Surface Temperature (LST) represents a valuable source of data for a simple modelling of the dynamic of soil moisture (SM) over large areas. In this paper we evaluated the capability of LST monthly anomalies, derived from the MOD11C3 standard product, to capture the SM dynamic as modelled over Europe by means of an ensemble of three land surface models. The direct use of LST as proxy of SM outperformed other LST-derived quantities, such as surface-to-air temperature gradient and day-night temperature variations, returning significant correlation values over the whole domain. LST performed better over Southern Europe compared to the Northern part of the domain, with the best results over areas characterized by water-limited conditions and moderate stress. Additionally, the analysis of the contingency matrix shows that the LST model is skillful in capturing extreme dry SM events, and it also has a good overall capability to correctly detect the dry events in 66% of the cases, with an average probability of false alarm of about 30%. Overall, the use of LST anomalies seems a promising starting point for a reliable modelling of the SM dynamic with a minimum amount of information. Even if the adopted approach is simple, the results are encouraging for a practical use of LST in an operational drought monitoring system over the study area.
Theory and Application of Magnetic Flux Leakage Pipeline Detection
Authors: Shi Yan , Zhang Chao , Li Rui , Cai Maolin , Jia Guanwei
Published: December 2015

Magnetic flux leakage (MFL) detection is one of the most popular methods of pipeline inspection. It is a nondestructive testing technique which uses magnetic sensitive sensors to detect the magnetic leakage field of defects on both the internal and external surfaces of pipelines. This paper introduces the main principles, measurement and processing of MFL data. As the key point of a quantitative analysis of MFL detection, the identification of the leakage magnetic signal is also discussed. In addition, the advantages and disadvantages of different identification methods are analyzed. Then the paper briefly introduces the expert systems used. At the end of this paper, future developments in pipeline MFL detection are predicted.
Compressive Sensing Based Design of Sparse Tripole Arrays
Authors: Hawes Matthew , Liu Wei , Mihaylova Lyudmila
Published: December 2015

This paper considers the problem of designing sparse linear tripole arrays. In such arrays at each antenna location there are three orthogonal dipoles, allowing full measurement of both the horizontal and vertical components of the received waveform. We formulate this problem from the viewpoint of Compressive Sensing (CS). However, unlike for isotropic array elements (single antenna), we now have three complex valued weight coefficients associated with each potential location (due to the three dipoles), which have to be simultaneously minimised. If this is not done, we may only set the weight coefficients of individual dipoles to be zero valued, rather than complete tripoles, meaning some dipoles may remain at each location. Therefore, the contributions of this paper are to formulate the design of sparse tripole arrays as an optimisation problem, and then we obtain a solution based on the minimisation of a modified l 1 norm or a series of iteratively solved reweighted minimisations, which ensure a truly sparse solution. Design examples are provided to verify the effectiveness of the proposed methods and show that a good approximation of a reference pattern can be achieved using fewer tripoles than a Uniform Linear Array (ULA) of equivalent length.
Pattern Switchable Antenna System Using Inkjet-Printed Directional Bow-Tie for Bi-Direction Sensing Applications
Authors: Eom Seung-Hyun , Seo Yunsik , Lim Sungjoon
Published: December 2015

In this paper, we propose a paper-based pattern switchable antenna system using inkjet-printing technology for bi-direction sensor applications. The proposed antenna system is composed of two directional bow-tie antennas and a switching network. The switching network consists of a single-pole-double-throw (SPDT) switch and a balun element. A double-sided parallel-strip line (DSPSL) is employed to convert the unbalanced microstrip mode to the balanced strip mode. Two directional bow-tie antennas have different radiation patterns because of the different orientation of the reflectors and antennas. It is demonstrated from electromagnetic (EM) simulation and measurement that the radiation patterns of the proposed antenna are successfully switched by the SPDT switch.
Robust 3D Position Estimation in Wide and Unconstrained Indoor Environments
Authors: Mossel Annette
Published: December 2015

In this paper, a system for 3D position estimation in wide, unconstrained indoor environments is presented that employs infrared optical outside-in tracking of rigid-body targets with a stereo camera rig. To overcome limitations of state-of-the-art optical tracking systems, a pipeline for robust target identification and 3D point reconstruction has been investigated that enables camera calibration and tracking in environments with poor illumination, static and moving ambient light sources, occlusions and harsh conditions, such as fog. For evaluation, the system has been successfully applied in three different wide and unconstrained indoor environments, (1) user tracking for virtual and augmented reality applications, (2) handheld target tracking for tunneling and (3) machine guidance for mining. The results of each use case are discussed to embed the presented approach into a larger technological and application context. The experimental results demonstrate the system’s capabilities to track targets up to 100 m. Comparing the proposed approach to prior art in optical tracking in terms of range coverage and accuracy, it significantly extends the available tracking range, while only requiring two cameras and providing a relative 3D point accuracy with sub-centimeter deviation up to 30 m and low-centimeter deviation up to 100 m.
Multiple-Parameter Estimation Method Based on Spatio-Temporal 2-D Processing for Bistatic MIMO Radar
Authors: Yang Shouguo , Li Yong , Zhang Kunhui , Tang Weiping
Published: December 2015

A novel spatio-temporal 2-dimensional (2-D) processing method that can jointly estimate the transmitting-receiving azimuth and Doppler frequency for bistatic multiple-input multiple-output (MIMO) radar in the presence of spatial colored noise and an unknown number of targets is proposed. In the temporal domain, the cross-correlation of the matched filters’ outputs for different time-delay sampling is used to eliminate the spatial colored noise. In the spatial domain, the proposed method uses a diagonal loading method and subspace theory to estimate the direction of departure (DOD) and direction of arrival (DOA), and the Doppler frequency can then be accurately estimated through the estimation of the DOD and DOA. By skipping target number estimation and the eigenvalue decomposition (EVD) of the data covariance matrix estimation and only requiring a one-dimensional search, the proposed method achieves low computational complexity. Furthermore, the proposed method is suitable for bistatic MIMO radar with an arbitrary transmitted and received geometrical configuration. The correction and efficiency of the proposed method are verified by computer simulation results.
Temporal Stability of Soil Moisture and Radar Backscatter Observed by the Advanced Synthetic Aperture Radar (ASAR)
Authors: Wagner Wolfgang , Pathe Carsten , Doubkova Marcela , Sabel Daniel , Bartsch Annett , Hasenauer Stefan , Blöschl Günter , Scipal Klaus , Martínez-Fernández José , Löw Alexander
Published: December 2015

The high spatio-temporal variability of soil moisture is the result of atmosphericforcing and redistribution processes related to terrain, soil, and vegetation characteristics.Despite this high variability, many field studies have shown that in the temporal domainsoil moisture measured at specific locations is correlated to the mean soil moisture contentover an area. Since the measurements taken by Synthetic Aperture Radar (SAR)instruments are very sensitive to soil moisture it is hypothesized that the temporally stablesoil moisture patterns are reflected in the radar backscatter measurements. To verify this hypothesis 73 Wide Swath (WS) images have been acquired by the ENVISAT AdvancedSynthetic Aperture Radar (ASAR) over the REMEDHUS soil moisture network located inthe Duero basin, Spain. It is found that a time-invariant linear relationship is well suited forrelating local scale (pixel) and regional scale (50 km) backscatter. The observed linearmodel coefficients can be estimated by considering the scattering properties of the terrainand vegetation and the soil moisture scaling properties. For both linear model coefficients,the relative error between observed and modelled values is less than 5 % and thecoefficient of determination (R2) is 86 %. The results are of relevance for interpreting anddownscaling coarse resolution soil moisture data retrieved from active (METOP ASCAT)and passive (SMOS, AMSR-E) instruments.
Optimal Control Approaches to the Aggregate Production Planning Problem
Authors: Davizón Yasser , Martínez-Olvera César , Soto Rogelio , Hinojosa Carlos , Espino-Román Piero
Published: December 2015

In the area of production planning and control, the aggregate production planning (APP) problem represents a great challenge for decision makers in production-inventory systems. Tradeoff between inventory-capacity is known as the APP problem. To address it, static and dynamic models have been proposed, which in general have several shortcomings. It is the premise of this paper that the main drawback of these proposals is, that they do not take into account the dynamic nature of the APP. For this reason, we propose the use of an Optimal Control (OC) formulation via the approach of energy-based and Hamiltonian-present value. The main contribution of this paper is the mathematical model which integrates a second order dynamical system coupled with a first order system, incorporating production rate, inventory level, and capacity as well with the associated cost by work force in the same formulation. Also, a novel result in relation with the Hamiltonian-present value in the OC formulation is that it reduces the inventory level compared with the pure energy based approach for APP. A set of simulations are provided which verifies the theoretical contribution of this work.
ANALYSIS OF THE RESPONSIVE ASPECTS OF THE TRADITIONAL PERSIAN HOUSE
Authors: Alkhansari Maryam Gharavi
Published: December 2015

The traditional Persian house is a representative of the culture, way of life, and beliefs of the Persian people during the golden era of Persian civilization in 17th to early 20th centuries. The goal of this paper is to analyze the responsive features of this traditional house in order to provide a more organized recognition of this structure and its fundamental principles. It seems that appreciation of such key principles may help to exit the current confusion in understanding cultural-spatial qualities in contem- porary Iranian housing.

In this regard, the paper will introduce the traditional Persian house, and will analyze its different aspects by using the seven criteria of Ian Bentley et al. in the book Responsive Environments (1985). This book speaks of broad, but somewhat universal concepts that can be applied across a wide range of areas such as old environments. This approach can be applied to reconsider the values of traditional environments. The criteria proposed are ‘permeability’, ‘variety’, ‘legibility’, ‘robustness’, ‘visual appropriateness’, ‘richness’ and ‘personalization’. This paper's analysis will be performed from three main viewpoints: functional-constructional, environmental, and social-cultural.

The paper discussions show that the responsiveness criteria are achieved in the traditional Persian house. It seems this achie- vement results from intelligent application of fundamental, structural principles of the traditional Persian house that provides suitable ground for answering functional-constructional, environmental and social-cultural issues through common solutions in an integrated entity.
INVESTIGATING ‘RELEVANCY’ OF THE TRADITIONAL PRINCIPLE OF THE RIGHT OF APPROPRIATION OF OPEN SPACE AND FINA’ IN CONTEMPORARY URBAN POOR COMMUNITIES IN CAIRO, EGYPT
Authors: Ahmed Khaled Galal
Published: December 2015

Many scholars have questioned ‘relevancy’ of the principles of traditional urbanism where contradictory discourses have accumulated over time especially during the past few decades but unfortunately without a reliving answer. This research is a humble attempt to question this relevancy in our modern time in the domain of urban poor communities in Cairo through investigation one of the essential traditional housing principles, namely, “the right of appropriation of open spaces and fina’”. A method of qualitative/quantitative work has been embraced in which first, the investigated principle was defined from various sources of literature, then, field investigations through multiple case studies were conducted to address the question of relevancy to the urban poor communities today. It has been found that the principle is relevant to the residents’ practices and significantly relevant to their attitudes. This opens the door for what might be considered as (re) legitimization of the principle, after considering its probable health and environmental impacts, through integrating it within the current social housing processes in Cairo and in Egypt as a whole.
SPATIAL PATTERN OF SUSTAINABLE URBAN DEVELOPMENT INDICATOR FOR THE MONTREAL URBAN COMMUNITY
Authors: Amin Shohel Reza , Tamima Umma
Published: December 2015

The City of Montreal initiated a First Strategic Plan for Sustainable Development in 2005 followed by a Community and Corporate Sustainable Development Plan in 2010–2015. This study proposes a sustainable urban development indicator (SUDI) for each Montreal Urban Community (MUC) to evaluate the achievements of sustainable development plans. This study identifies thirty-two variables as the attributes of sustainable urban development. The multivariate technique and Exploratory Spatial Data Analysis are applied to determine the spatial pattern of SUDI for each MUC. The spatial pattern of SUDI identifies that Ville Marie, Verdun, Sud-Ouest, Mercier-Hochelaga-Maisonneuve and Plateau Mont-Royal have strong sustainable development. The findings of this study help the City of Montreal to understand the improvement of the sustainable development plans for Montreal city and to distribute the municipal budget for the community benefits accordingly.
The Recapitulation of Obama´s Security and Defence Policy. The End of his First Presidential Term
Authors: Rašek Antonín
Published: December 2015

The results of American foreign, security, defence and military policies are ambiguous. The war in Iraq ends, troops are going to leave both Iraq and Afghanistan. Obama was held up in Arab spring. He tried to improve relations with Russia. The centre of gravity was moved to the Pacific area, which got complicated ties with People's China. He didn't succeed in solving troubles with nuclear programme in Iran. His moderate success in foreign policy was the consequence of his concentration on home politics, health care reform, economy and financial crises. At the end the essay evaluates the Chicago summit that among others officially affirmed that NATO activities in Afghanistan would be concluded by 2014 and declared the so-called smart defence.
Legal and Illegal Wars in Present-day World
Authors: Eichler Jan
Published: December 2015

After the year 1990 a total of 120 wars have taken place. The most appealing were those initiated by the USA, in which other friendly states´ve participated as well. No country has the right to invade its neighbour or over-run and annex another. There were many discussions in the world over the legacy of imposed interventions, under which conditions they are true and just. The study covers two dissimilar attitudes: the first one against Hussein's expansionist policy in 1991 and warfare after 9/11 2001. The legitimacy rests upon Resolutions of the United Nations Security Council that allow any nation to remove the aggressor by force. The author also mentions a series of wars, fought throughout the former Yugoslavia from 1991 to 1995, and then again from 1998 until 1999/2001.