bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Cytauxzoon felis Cases in Domestic Cats from Eastern Kansas, a Retrospective Case-Control Study (2006–2019)
Authors: Wikander Yvonne M. , Kang Qing , Reif Kathryn E.
Published: December 2020

Cytauxzoon felis, a tick-borne hemoprotozoal pathogen of felids, causes an acute, often-fatal disease in domestic cats. While public awareness of the disease has increased, few studies have evaluated the incidence of acute cytauxzoonosis cases and their associated risk factors. The objective of this study was to retrospectively review records of cats diagnosed with acute cytauxzoonosis in eastern Kansas from 2006–2019 using clinic records and determine: (i) feline cytauxzoonosis risk factors; and (ii) if cytauxzoonosis case incidence is increasing. Although inter-annual variation of acute cytauxzoonosis diagnosis was observed in the eastern Kansas domestic cat population, the overall incidence trend remained largely unchanged over the 14-year case review period. In comparison to ill (C. felis-unrelated) control cases, more acute cytauxzoonosis cases were diagnosed in spring and summer, suggesting a seasonal fluctuation of infection, with samples most commonly submitted from ≥1 year old, owned, male cats. Although cytauxzoonosis case submissions remained consistent over the broad study period, increasing tick vector and domestic cat reservoir populations may contribute to additional cytauxzoonosis case expansion in endemic areas. Investigating the incidence of acute cytauxzoonosis, patient risk factors, and ecological variables that influence disease transmission are important steps towards developing and communicating the need for effective cytauxzoonosis control strategies for high-risk cat populations.
Antimicrobial Peptides in Farm Animals: An Updated Review on Its Diversity, Function, Modes of Action and Therapeutic Prospects
Authors: Kumar Rohit , Ali Syed Azmal , Singh Sumit Kumar , Bhushan Vanya , Mathur Manya , Jamwal Shradha , Mohanty Ashok Kumar , Kaushik Jai Kumar , Kumar Sudarshan
Published: December 2020

Antimicrobial peptides (AMPs) are the arsenals of the innate host defense system, exhibiting evolutionarily conserved characteristics that are present in practically all forms of life. Recent years have witnessed the emergence of antibiotic-resistant bacteria compounded with a slow discovery rate for new antibiotics that have necessitated scientific efforts to search for alternatives to antibiotics. Research on the identification of AMPs has generated very encouraging evidence that they curb infectious pathologies and are also useful as novel biologics to function as immunotherapeutic agents. Being innate, they exhibit the least cytotoxicity to the host and exerts a wide spectrum of biological activity including low resistance among microbes and increased wound healing actions. Notably, in veterinary science, the constant practice of massive doses of antibiotics with inappropriate withdrawal programs led to a high risk of livestock-associated antimicrobial resistance. Therefore, the world faces tremendous pressure for designing and devising strategies to mitigate the use of antibiotics in animals and keep it safe for posterity. In this review, we illustrate the diversity of farm animal-specific AMPs, and their biochemical foundations, mode of action, and prospective application in clinics. Subsequently, we present the data for their systematic classification under the major and minor groups, antipathogenic action, and allied bioactivities in the host. Finally, we address the limitations of their clinical implementation and envision areas for further advancement.
Challenges and Opportunities for Integrating In Silico Models and Adverse Outcomes Pathways to Set and Relate New Biomarkers
Authors: dos Santos Carlos E. Matos , Miranda Raul Ghiraldelli , de Oliveira Danielle Palma , Dorta Daniel Junqueira
Published: December 2020

The Adverse Outcome Pathway (AOP) framework has been considered the most innovative tool to collect, organize, and evaluate relevant information on the toxicological effects of chemicals, facilitating the establishment of links between molecular events and adverse outcomes at the critical level of biological organization. Considering the combination of the high volume of toxicological and ecotoxicological data produced and the application of artificial intelligence algorithms from the last few years, not only can higher mechanistic interpretability be reached with new in silico models, but also a potential increase in predictivity in hazard assessments and the identification of new potential biomarkers can be achieved. The current paper aims to discuss some potential challenges and ways of integrating in silico models and AOPs to predict toxicological effects and to set and relate new biomarkers for defined purposes. With the use of the AOP framework to organize the ecotoxicological, toxicological, and structural data generated from in chemico, in vitro, ex vivo, in vivo, and population studies, it is expected that the generated biological and chemical construct will improve its application, establishing a knowledge platform to set and relate new biomarkers by key event relationships (KERs).
Experimenting Transition to Sustainable Urban Drainage Systems—Identifying Constraints and Unintended Processes in a Tropical Highly Urbanized Watershed
Authors: Chapa Fernando , Pérez María , Hack Jochen
Published: December 2020

Green Infrastructure promotes the use of natural functions and processes as potential solutions to reduce negative effects derived from anthropocentric interventions such as urbanization. In cities of Latin America, for example, the need for more nature-based infrastructure is evident due to its degree of urbanization and degradation of ecosystems, as well as the alteration of the local water cycle. In this study, an experimental approach for the implementation of a prototype is presented. The prototype consists of a gray-hybrid element for first flush bio-treatment and runoff detention, adapted to the existing stormwater sewer. The experiment took place in a highly urbanized watershed located in the Metropolitan Area of Costa Rica. The characteristics of the existing infrastructure in the study area at different scales were mapped and compared using the Urban Water System Transition Framework. Subsequently, preferences related to spatial locations and technologies were identified from different local decision-makers. Those insights were adopted to identify a potential area for the implementation of the prototype. The experiment consisted of the adaptation of the local sewer to act as a temporal reservoir to reduce the effects derived from rapid generation of stormwater runoff. Unexpected events, not considered initially in the design, are reported in this study as a means to identify the necessary adaptations of the methodology. Our study shows from an experimental learning-experience that the relation between different actors advocating for such technologies influences the implementation and operation of non-conventional technologies. Furthermore, the willingness of residents to modify their urban environments was found to be associated to their own perceptions about security and vandalism occurring in green spaces. The implementation of the prototype showed that both the hydraulic performance is relevant for considering it as a success, as well as the dynamics of the adapted element with the existing urban conditions. In consequence, those aspects should be carefully considered as the design factors of engineering elements when they are related to complex socio-ecological urban systems.
ANALISIS PENGARUH FAKTOR-FAKTOR DEMOGRAFI TERHADAP KEPATUHAN PERPAJAKAN
Authors: Mulyani Sri , Budiman Nita Andriyani , Sakinah Riyadlus Mei
Published: December 2020

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh faktor-faktor demografi terhadap kepatuhan perpajakan. Pengumpulan data dilakukan dengan cara menyebarkan kuesioner dan jumlah sampel sebanyak 100 responden. Penelitian ini dilakukan di KPP Pratama Kudus. Data dianalisis dengan menggunakan uji Chi-Square. Faktor demografi yang diteliti meliputi jenis kelamin, umur, tingkat pendidikan, status pernikahan, jenis pekerjaan, dan tingkat penghasilan. Hasil penelitian ini menunjukkan bahwa responden laki-laki dan perempuan mempunyai kepatuhan perpajakan yang sama sedangkan untuk umur, tingkat pendidikan, jenis pekerjaan, dan tingkat penghasilan memiliki tingkat kepatuhan pajak yang berbeda.
Sistema Genito - Urinario y Endocrino
Authors:   Zambrano Pincay, Graciela Hernestina, Patricio Alfredo Vallejo Valdivieso
Published: December 2020

El libro abarca temáticas como problemas renales, las enfermedades en embarazadas y trastornos hipertensivos gestacionales cuyos síntomas requieren ser conocidos por el ser humano a fin de tener conciencia de los mismos y reconocerlos en el momento en el cual se puedan presentar. Autores: Patricio Vallejo al et.
Migrantes y trabajo forzado: enfoque normativo en México y tendencias jurisprudenciales en cortes regionales
Authors: Bernal Ballesteros María José , De Paz González Isaac
Published: December 2020

El flujo de migrantes se ha incrementado en todo el mundo. La causa de origen es la pobreza e inequidad social. En respuesta, y con el objeto de prevenir y erradicar el trabajo forzado, el derecho internacional y nacional contempla disposiciones para proteger a los migrantes. No obstante, los procedimientos de protección a los migrantes en gran medida dependen de la jurisdicción nacional. El artículo tiene dos objetivos: estudiar los ejes normativos sobre la situación actual que viven los trabajadores migrantes en torno a la discriminación y a la protección jurídica de sus derechos laborales; y reconocer el desarrollo jurisprudencial sobre el trabajo forzado en cortes constitucionales y regionales. La aportación significativa del artículo radica en mostrar que hay un desarrollo creciente de legislación nacional e instrumentos de protección internacionales, que se usan tanto en procedimientos civiles o penales para erradicar el trabajo forzado de los migrantes como grupo vulnerable.
El derecho a la propia imagen de niñas, niños y adolescentes frente a las tecnologías de información y comunicación (la responsabilidad que tienen quienes ejercen la patria potestad)
Authors: GOMEZ GALLARDO Perla
Published: December 2020

El objetivo de este artículo es reflexionar sobre los alcances, límites y responsabilidades de quienes ejercen la patria potestad de niñas, niños y adolescentes, con relación al respeto al derecho a la imagen y el interés superior de la niñez cuando difunden sus imágenes a través de las Tic´s. Lo anterior desde una visión ética, del principio de responsabilidad con enfoque desde la dignidad, los derechos de la personalidad en el aspecto del patrimonio moral del derecho a la imagen y la intimidad y sus implicaciones contemporáneas.
¿Educación intercultural? A propósito del fenómeno migratorio venezolano en Medellín
Authors: Baena Robledo Natalia , Cardona Zuleta Elvigia
Published: December 2020

A partir de un ejercicio de investigación, que arrojó información diagnóstica acerca de la situación de derechos de la población migrante en la ciudad de Medellín, el presente artículo tiene como propósito analizar el Derecho a la Educación de los migrantes venezolanos en Medellín desde una postura intercultural, permitiendo una reflexión que interrogue a las Instituciones de Educación sobre sus procesos de adaptación a los fenómenos migratorios y evidenciar las contribuciones (o no), las oportunidades y desafíos que exige una adaptación de la Educación en términos del acceso.  La Educación es un eje aporta para transformar la mirada del fenómeno migratorio, y entenderlo como algo que nutre la construcción colectiva, una oportunidad para enriquecer los procesos sociales existentes a partir de la diversidad y el pluralismo, como una respuesta a la necesidad de acceso a derechos de la población migrante.
Evolución de los regímenes internacionales de refugio y migración y los retos tras la aprobación de los nuevos pactos mundiales
Authors: Muñoz Bravo Tomás Milton
Published: December 2020

Al concluir la Segunda Guerra Mundial se empezó con la construcción de regímenes internacionales para atender, primero, a los desplazados de la conflagración en Europa y, después, a migrantes y refugiados en el resto del mundo, que incluyó la aprobación de convenciones, protocolos e instituciones en las siguientes décadas. El esfuerzo, que no ha estado carente de tropiezos, ha recibido un nuevo impulso con la aprobación de dos pactos en 2018 en el seno de la Organización de Naciones Unidas (ONU) y que pretenden generar lineamientos generales para atender la movilidad internacional de las personas de manera ordenada y segura.Por lo anterior, el presente trabajo tiene como principal objetivo hacer una revisión cualitativa de la construcción de dichos regímenes para después analizar los retos que enfrenta la comunidad internacional en la implementación de los dos nuevos pactos mundiales sobre refugio y migración en un contexto marcado por la xenofobia y los ultranacionalismos.
The Dignity of the Person in the Context of Human Providence
Authors: Mazur Piotr S.
Published: December 2020

Thomas Aquinas understands providence as the reason of directing things to ends (ratio ordinis rerum in finem), and as the execution of that directing, i.e. governance (gubernatio). Thus, providence is one of the fundamental attributes of the person that reveals the person's perfection and dignity. Providence consists in a free and reasonable directing of oneself and the reality subject to oneself in order to actualize potentialities of oneself and of other beings in the context of the ultimate goal of existence. Human providence joins the providence of the Absolute with regard to the world. In spite of its deficiencies human providence reveals the essential dignity of the human person.
Piotr Moskal: Religia i prawda
Authors: Piwowarczyk Marek
Published: December 2020

The article reviews the book Religia i prawda [Religion and Truth], by Piotr Moskal.
Affective Knowledge of God
Authors: Moskal Piotr
Published: December 2020

Affective knowledge of God is a kind of knowledge which follows human affectivity. This knowledge takes place on two levels: the level of the natural inclination of man towards God and the level of the religious bias of man towards God. What is the nature of affective knowledge of God? It seems there are three problems in question. First of all, as there is a natural inclination towards God in man, one will be restless unless one recognizes or finds God. Secondly, one who loves God has a new deeper knowledge of the divine things through connaturality and inclination. Thirdly, as the result of one's encounter with God and of uniting with Him, man experiences certain subjective states which cannot be expressed by words.
False Optimism? Leibniz, Evil, and the Best of all Possible Worlds
Authors: Strickland Lloyd
Published: December 2020

Leibniz’s claim that this is the best of all possible worlds has been subject to numerous criticisms, both from his contemporaries and ours. In this paper I investigate a cluster of such criticisms based on the existence, abundance or character of worldly evil. As several Leibniz-inspired versions of optimism have been advanced in recent years, the aim of my investigation is to assess not just how Leibniz’s brand of optimism fares against these criticisms, but also whether optimism as a philosophy has the resources to meet these challenges. I show that none of the criticisms considered has sufficient force to pose a threat to Leibniz’s version of optimism or to one modelled on it.
Madhuri Santanam Sondhi: Intercivilizational Dialogue on Peace
Authors: Hope Vincent
Published: December 2020

The article reviews the book Intercivilizational Dialogue on Peace, by Madhuri Santanam Sondhi.
All-Unity according to V. Soloviev and S. Frank. A Comparative Analysis
Authors: Obolevich Teresa
Published: December 2020

In this article I will present and analyze the concept of all-unity of the two most famous Russian philosophers—Vladimir Soloviev (1853–1900) and Semyon Frank (1877–1958). As will be argued, the concept of all-unity is part of an old philosophical tradition. At the same time, it is an original idea of the Russian thought of the Silver Age (the end of the 19th and the first half of the 20th centuries).
Spinoza und Seine Philosophie im Schaffen der Deutschsprachigen Dichterin Rose Ausländer
Authors: Kłańska Maria
Published: December 2020

The German-Jewish writer and poetess, Rose Ausländer (1901–1988), who came from Chernivtsi (Czernowitz), capital of Bukovina, one of the former provinces of the Hapsburg Empire, is one of the most highly acclaimed lyric poets to have written in German in the 20th century. Throughout her whole life she was an adherent of the philosophy of Spinoza, first becoming acquainted with it in the so-called “ethics seminar” of the secondary-school teacher Friedrich Kettner. In the wake of the First World War the youth of Chernivtsi were in need of new sources of intellectual stimulation, so he set out to introduce them to the philosophy of Spinoza, as well as to that of Constantin Brunner, a contemporary German philosopher influenced by him. Rose Ausländer remained a follower of Spinoza right up to the end of her life. This is confirmed by her two very different poems of the same name, “Spinoza”—the first composed before 1939, the second in 1979—as well as by her many explorations of topics drawn from his ethics, ranging from her very first printed poem, “Amor Dei,” up to her lyrics written in old age, in the 1970s and 1980s. In this short paper I will attempt to chart the course of, and analyze, her interest in Spinoza's philosophical system and life.
Irena Stasiewicz-Jasiukowa ed.: The Contribution of Polish Science and Technology to World Heritage
Authors: Kupczak Rafał
Published: December 2020

The article reviews the book The Contribution of Polish Science and Technology to World Heritage, edited by Irena Stasiewicz-Jasiukowa.
Implementasi Media E-commerce pada Pemasaran Kain Sutra Mandar di Polewali Mandar
Authors: S Asmawati , Sari Dian Megah
Published: December 2020

Tujuan dari penelitian ini adalah mengembangkan sistem informasi yang digunakan untuk meningkatkan pemasaran produk sarung sutra mandar, serta mengetahui kepraktisan dan efektivitas software dalam mengimplementasikan pemasaran sarung sutra mandar berbasis e-commerce. Penelitian ini merupakan jenis penelitian R&D (Research and Development) dengan menggunakan model pengembangan prototype. Hasil perancangan sistem meliputi dua bagian yaitu: halaman yang dapat diakses oleh pengunjung dan pelanggan dan halaman admin yang digunakan untuk mengelola informasi detail dalam menyimpan informasi terkait produk yang dipasarkan. Pemasaran yang menggunakan media e-commerce dapat memberikan kemudahan dalam proses pengecekan barang, proses pemesanan, dan pembayaran kepada toko dan konsumen atau sehingga dapat membangun hubungan timbal balik yang lebih baik
Penerapan Enterprise Architecture pada Penerimaan Mahasiswa Baru menggunakan TOGAF di Universitas X Palembang
Authors: Lathifah Lathifah
Published: December 2020

Enterprise architecture sangat diperlukan oleh semua organisasi salah satunya yaitu universitas, universitas memiliki banyak sektor bisnis didalamnya  salah satunya yaitu pada sistem penerimaan mahasiswa baru. Sistem penerimaan mahasiswa baru yang dimiliki oleh universitas X Palembang memiliki beberapa kendala dalam mengelolanya. Apakah dengan diterapkannya proses enterprise architecture  proses bisnis yang ada bisa terintegrasi dengan baik? Metodologi penilaian penerapan tersebut menggunakan TOGAF yang mengacu pada proses architecture business, architecture data, architecture application, dan architecture technology. Hasil penerapan yang didapat dari nilai tersebut yaitu memiliki nilai rata-rata 2,23% dengan kata lain penerapan enterprise architecture pada Universitas X Palembang telah digunakan dengan baik pada sistem penerimaan mahasiswa baru sehingga dapat berjalan dan terintegrasi menjadi satu, serta bisa dijadikan referensi dalam menerapkan enterprise architecture berikutnya pada sistem-sistem yang lain di universitas x. Adapun masalah yang muncul yaitu data pada penerimaan mahasiswa baru belum dikelola dengan baik dokumentasinya, sehingga Universitas X Palembang mengalami kesulitan dalam mengelolanya.
Intention to Use Mobile Learning in Higher Education Institutions: Review Paper
Authors: Izkair Ayad Shihan , Lakulu Muhammad Modi , Mussa Ibtihal Hassan
Published: December 2020

Mobile learning is presently taking part in associate degree more and more important role within the instructional method, additionally as within the development of teaching and learning ways for higher education. The power to find out ‘on the go– anytime, anywhere, is changing into more and more fashionable. The advantages offered by mobile learning are important. On the opposite hand, the implementation of mobile learning in educational activity relies on users’ acceptance of technology. Acceptance and intention to use mobile learning may be a topic of growing interest within the field of education. The model of the unified theory of acceptance and use of technology (UTAUT) is planned and developed by researchers via a mixture of eight major theories in activity prediction. UTAUT is among the foremost fashionable and up to date model in information technology acceptance. This is review paper aiming to review UTAUT’s previous studies of intention to use mobile learning. In conclusion, this research provides insight regarding the necessary factors for planning and designing an intention to use mobile learning model in higher education institutions.
Teachers’ Information and Communication Technology (ICT) Skills Assessment: Basis for a Comprehensive ICT Training Program
Authors: Bayucca Shallimar
Published: December 2020

The study described the extent of knowledge in ICT skills of 180 teachers as a basis for a training plan in a selected schools division in Region 3. A descriptive survey method was utilized having a weighted mean and standard deviation to treat the data collected. It was concluded that the teachers displayed a proficient extent of knowledge in basic ICT skills. However, some of the skills enumerated have a low mean and were close to the adjacent group scale of the lower level of knowledge. Furthermore, they showed limited knowledge in some advanced computer applications which are necessary for the construction of instructional materials. The self-assessment revealed that they are knowledgeable in ICT skills, but they do not know how to use it in complex applications. The skills for development based on the training needs assessment reiterated a combination of skills which further clarified that not all skills under a certain application are known. It is then recommended that training needs assessment should always be conducted by school administrators to gather data on the actual needs of the teachers as a basis in planning a thorough training matrix to ensure that the development and training provided are based on the needs of the teachers.
Fostering Innovation and Methodology through Experiential Learning for Data Structures
Authors: Dr. Anitha Kumari , Dr. Nanda Gopal , Padmashani Padmashani
Published: December 2020

For real-life work environment, developing employability skills by the students’ community is indispensable and need of the hour. Laboratories associated with courses cultivate the ability of students to think independently and promote employability skills through experiential learning. Data structures are one such predominant course in IT/CSE domain to enhance the skill set of students for Placements/Higher studies. It provides opportunity for students to devise algorithms efficiently in an optimal manner by solving challenging problems easily thereby gaining confidence for attending placements. The purpose of this paper is to foster innovation by exploration in data structures course through experiential learning by providing coding based challenging questions as tutorials, assignment presentations and as activities during laboratory sessions and online classes are to be conducted as an essential one in the future learning perspective. Findings conclude that the experiential learning foster student’s abilities in solving the problem and thereby gaining confidence during e-learning and placement activities and the grading process are to be updated through centralized servers to the maximum extend and accuracy are to be maintained.
Role of Afghan Women in War against British
Ahmad Wali Alemi,
Authors: Alemi Ahmad Wali
Published: December 2020

The presence of Afghan women in Afghan society in major national and local decision-making is faded and often marginalized. But they have a key role in the production and processing of resources that are unfortunately deprived of ownership. On the contrary, in issues such as conflict, Afghan women are present on the battlefields and stand on the train with their men in a single row, fighting with their enemies and defending their country. With the end of the war, their role does not end, but they are also involved in more serious decisions related to the war.One good example of this can be remembered in the nineteenth and twentieth centuries, that Afghan women have played a key role in the solution of local conflicts in Afghan tribal society and, through the Jirga and the Soviets, have made peace with the warring factions and ultimately. Ends of strife, war, and hostility have become essential. Therefore, in this article, citing the archives and historical sources, efforts have been made to express the role of Afghan women in War against the British and to investigate their activities.
Anaerobic Digestion of Cassava (Manihot Esculenta) Waste: Effects of Inoculum on Biogas Production Rate
Authors: Eboibi B.E. , Adiotomre K.O. , Onobrudu F. , Osioh E.
Published: December 2020

In this paper, cow manure fluid was used as inoculums to investigate biogas production rate from anaerobic digestion of cassava peel at mesophilic temperature (280C). The anaerobic experiment was conducted using six batch digesters (D1, D2, D3, D4, D5 and D6) each of 20L capacity for 40-day hydraulic retention. Each digester, was loaded with 5kg of cassava peel (CP) and 0%, 10%, 20%, 30%, 40% and 50% of inoculum to CP. Hashimoto model was used to obtain the digestion kinetic parameters. The results of the study showed that inoculums influenced the rate of biogas production, showing variations in biogas production, correlation coefficient (R2) and in first-order decay constant (k). The average cumulative biogas production was in the range of ~2358 to 4010ml/kgVS for 10% to 50% inoculum. The R2 and k for D1 was 0.959 and 0.359 D1 (without inoculum), 0.990 and 0.371 for D2 (10% inoculum) and 0.991 and 0.371 for D3 (20% inoculum), 0.951 and 0.356 for D4 (30% inoculum), 0.992 and 0.372 for D5 (40% inoculum), and 0.990 and 0.371 was obtained for D6 loaded with 50% inoculum. Despite variation in biogas yields from different inoculums, biogas production obtained from anaerobic digesters loaded with inoculums were still lower compared with that without inoculum.
SCOPE OF SPEECH LANGUAGE THERAPY
Authors: Asif Siddiqui Amina
Published: December 2020

The consistent indulgence of the developed world in neurological research, during the post second world war era, led to several discoveries and subsequently the laying down of several theories about socio-communicative behaviors in human beings. The areas of the brain responsible for the functions of speech and language were studied further, providing an insight to the role of the brain in cognitive skills of attention, recall, memory, analytical and inferential skills, as well as judgment, necessary during verbal and nonverbal communication. Information about cerebral dominance for language, which lies in the left hemisphere for a larger majority of people; led to establishing the role of the right hemisphere for the supra-segmental features of language, or the meaning of spoken utterances carried by the rhythm in our speech. Thus ‘aphasiology’ emerged as the ‘study of aphasia’ which is an acquired language disorder that results from an insult to the brain, mostly in adults who have used language in the best possible way through their lives; but may also be seen in children known as ‘childhood aphasia.’ The period and pattern of recovery from aphasia varied greatly in adults and children, which led to establishing the theory of ‘critical period’ for language development, shedding more light on the miraculous development and functioning of the human neurological system since birth, for language. Knowledge about the rapid development of the human brain in the early years of life led to the essential concept of ‘early intervention’ of children having any communicative or physical challenges
ROLE OF LEE SILVERMAN VOICE TREATMENT (LSVT) IN PARKINSON DISEASE
Authors: Imran Farooqui Sumaira
Published: December 2020

Parkinson Disease is a progressive neurological disorder that affects approximately seven to ten million population across the globe, prevalence of disease increase with age , nearly four percent of total population suffering from Parkinson Disease are diagnosed before the age of 50 years, men are having one and a half times more chance of developing a disease as compared to females. It is the sixth most common among the neurological disorders seen in urban United Kingdom, with an incidence of about 2.8% in the US;unfortunately there is lack of related statistics available for Pakistani population. However, there is a reported increase in the overall prevalence of neurological diseases in Pakistan and it is reported that more middle aged Pakistani males suffers from Parkinson Disease as compared to females, displaying a worsening of symptoms and possible deficits in cognition as age progresses.
PEMODELAN APLIKASI PENDUKUNG KEPUTUSAN MAKANAN PENDAMPING AIR SUSU IBU (MPASI) BERBASIS ANDROID
Authors: Nazli Rabby , Erlinda Erlinda
Published: December 2020

Complementary foods breast milk (MPASI) is a very important thing for growth and development in a baby, to achieve optimal growth and development process, balanced nutrition is needed, even nowadays babies are often stunted or have malnutrition. Good parents, of course, do not just provide complementary foods to their babies but will pay attention to whether or not the MPASI nutrition is given. By modeling an MPASI guide application, it can help parents determine the right nutrition to give to their babies and parents can make the right decisions and find out the nutritional status of their babies. Modeling this application using Unifield Modeling Language (UML) and implemented into the application using Android Studio. From the resulting application model, it can help and provide references to parents in providing balanced nutrition for their babies.
Diet Kalsium pada Ibu Hamil
Authors: Adyani Kartika
Published: December 2020

Kalsium merupakan mineral yang peting untuk pembentukan tulang, kontraksi otot, dan metabolisme enzim dan hormon. Pembentukan jaringan pada janin membutuhkan kalsium sehingga kebutuhan kalsium pada ibu hamil meningkat. Ibu hamil yang mendapatkan asupan kalsium < 500 mg/hari berisiko mengalami pengurangan massa tulang selama kehamilan. Asupan kalsium terendah di dunia terjadi pada negara berkembang khususnya Asia. Suplementasi kalsium pada kehamilan dikaitkan dengan penurunan risiko hipertensi dalam kehamilan, kelahiran prematur, dan peningkatan berat lahir. Tujuan dari penyusunan artikel ini adalah untuk mengetahui diet kalsium untuk ibu hamil. Artikel ilmiah ini merupakan tinjauan literatur. Hasil studi literatur ini memaparkan manfaat kalsium untuk ibu hamil, faktor-faktor yang mempengaruhi asupan kalsium pada ibu hamil, dampak kekurangan kalsium bagi ibu hamil. Kesimpulan dari artikel ini adalah kalsium dibutuhkan oleh ibu hamil untuk pertumbuhan dan perkembangan janin dalam kandungan. Asupan kalsium sesuai rekomendasi (± 1300 mg/hari) secara signifikan dapat mengurangi risiko kelahiran prematur.
Differentiated Instructions in Teaching English for Students with Autism Spectrum Disorder
Authors: Sandra Lifia Alex , Kurniawati Lemmuela Alvita
Published: December 2020

This study aims to explore the use of differentiated instructions in teaching English for students with Autism Spectrum Disorder (ASD) and  investigate English teachers’ views on the extent of differentiated instructions in teaching English for students with ASD. The participants of this study was two English lecturers of English language education department in a private inclusive university in Indonesia. Employing qualitative method, this study used the data gathered from the interviews with the participants. This study used thematic analysis and generated five themes regarding to the use of differentiated instructions and teachers’ views on it. The first three themes were used to explain the extent of differentiated instructions in teaching English for students with ASD. The first three themes are the participants used differentiated class-assignments for students with ASD in their English class, they used differentiated content materials for students with ASD, and lastly, they provided outside-class assistance for students with ASD. The last two themes were used to reveal teachers’ vi.ws on the extent of differentiated instructions in teaching English for students with ASD. First, differentiated instructions lessened the level of anxiety of students with ASD, and second, differentiated instructions provided a positive learning environment for students with ASD. Based on the results and limitation of the study, some implications, contributions, and suggestions for future studies are presented.
A Comparison of Using L1 (Indonesian) and English to Answer English Listening Comprehension Questions
Authors: Rahmah Ismi Putri , Halimi Sisilia Setiawati
Published: December 2020

English test results show that a lot of Indonesian students obtained low scores in listening. Students say they understand what speakers say in an English listening test but they have difficulties in answering the questions in English. This shows that students’ English receptive skills are higher than students’ productive skills. This research intends to find out what the difference in results is when students answer English listening comprehension questions in L1 (Indonesian) and English, and what the students’ perception is on the use of Indonesian language in English listening test. This research uses the mixed method along with a listening test, questionnaires, and interview as data collection tools. The findings show that these learners have difficulties to answer the test in English. The test answered in Indonesian received better scores than in English. Moreover, the questionnaires and the interview result show positive feedback on the use of Indonesian language. This shows that the learners actually have good listening skills and that their low-test scores are mostly due to their difficulty in expressing their thoughts in English.
Health Inequalities in Under-Five Mortality: An Assessment of Empowered Action Group (EAG) States of India
Authors: Kumar Sarvesh , Sahu Damodar , Mehto Amit , Kumar Sharma Ravendra
Published: December 2020

Background: The effect of childhood well-being programs is commonly interconnected with a change in mortality trends. The proportion of disparity shows that inequality in child mortality is more collective in the similarly evolved states than the poorer states in India.

Objective: To estimate and compare the health inequality of under-five mortality in Empowered Action groups (EAG) states of India.

Methods: Data from the National Family Health Survey (NFHS-4) was used only for the EAG States of India. Under-five mortality rates (U5MR) were calculated for associated background characteristics by using the life table method. Wealth inequality was assessed separately for all EAG states by calculating measures of concentration index (CI). Concentration curves (CC) were also plotted to see the difference in inequality.

Results: Higher U5MR was observed in all EAG states compared with estimates for overall India. On comparing estimates of inequality, CI values show the substantial burden of U5MR among EAG states of India. The CC shows the lowest inequality in EAG states of India.

Conclusion: The results suggested the need to receive various health strategy intercessions in agreement with the instance of ever-changing commitments of economic components to child health disparities in EAG states. Measuring the impact of determinants to wealth-related inequality in U5MR helps in lining up the interventions targeted at improving child survival.
Виявлення та ідентифікація східної каштанової горіхотворки Dryocosmus kuriphilus Yasumatsu
Authors:   Інститут захисту рослин НААН, Борзих Олександр , Скрипник Наталія ,   Інститут захисту рослин НААН
Published: December 2020

Наведено відомості про поширення, шкідливість, морфологічні та біологічні особливості східної каштанової горіхотворки Dryocosmus kuriphilus Yasumatsu. Для визначення видової належності подано діагностичні ознаки. Робота становить теоретичний та практичний інтерес для фахівців захисту і карантину рослин, спеціалістів фітосанітарних лабораторій, керівників та спеціалістів господарств, студентів, науковців та викладачів сільськогосподарських вузів.
Comparative Study: Statistical Approach and Deep Learning Method for Automatic Segmentation Methods for Lung CT Image Segmentation
Authors: Dr. Akey Sungheetha  , Dr. Rajesh Sharma R
Published: December 2020

Recently, deep learning technique is playing important starring role for image segmentation field in medical imaging of accurate tasks. In a critical component of diagnosis, deep learning is an organized network with homogeneous areas to provide accurate results. It is proved its superior quality with statistical model automatic segmentation methods in many critical condition environments. In this research article, we focus the improved accuracy and speed of the system process compared with conservative automatic segmentation methods. Also we compared performance metrics such as accuracy, sensitivity, specificity, precision, RMSE, Precision- Recall Curve with different algorithm in deep learning method. This comparative study covers the constructing an efficient and accurate model for Lung CT image segmentation.
A construção histórica conceitul da Termodinâmica para o Ensino Médio
Authors: Da Silva Geilson Rodrigues , Guimarães Errobidart Nádia Cristina
Published: December 2020

Apresentamos na presente pesquisa um produto pedagógico divido em dois textos desenvolvido no âmbito do mestrado profissional de Ensino de Ciências. Utilizamos de uma discussão pautada nos aspectos históricos contextual para evidenciar como evoluiu determinados conhecimentos, diminuindo assim as chances de os estudantes desenvolverem concepções estáticas, dogmáticas acerca da Natureza da Ciência. Para isso organizamos as caixas pretas com o seguinte sistema de cores: Alaranjado para a História, o verde musgo para a Geologia, o verde para a Física, o ouro claro para aplicação social das máquinas térmicas. As caixas pretas, apresentam informações que orientariam uma discussão sobre o processo de desenvolvimento científico da Termodinâmica no contexto da Revolução Industrial, explorando uma abordagem histórica e contextual. Cada docente pode decidir a extensão e a profundidade da abertura das caixas pretas e utilizar o produto para dar suporte para a sua discussão.
2020: Mundo Pandêmico e os reflexos na região de Fronteira São Borja - Brasil e Santo Tomé – Argentina
Authors: Vieira Maurício Aires , Silva Dilossane Vargas da , Silva Thaís Vargas da , Cortes Marilice Cortes , Mota Rafael Silveira da
Published: December 2020

A mudança inesperada no convívio social a nível mundial se deve à situação de alerta proposta pelos órgãos de saúde pública, a qual é quase unânime entre os cientistas e pesquisadores da área epidemiológica por não haver uma forma definitiva e segura de frear a disseminação do SARS-CoV-2, e veem como única medida preventiva e eficaz o isolamento social. Este artigo tem como objetivo interpretar o contexto atual de pandemia do COVID 19, considerando o ano de 2020 como um grande marco histórico mundial, devido à emergência de saúde pública global. Para isso, busca-se analisar o permanente estado de crise em que vivemos, apontando as consequências da quarentena nas relações sociais na região de fronteira São Borja - Brasil com Santo Tomé – Argentina; os desafios do cenário atual e pós pandemia mundial. Salienta-se que será necessário repensar a organização da vida em sociedade, e as relações com a natureza, social, política e econômica, pois caso contrário, o estado de crise em que vivemos dilatará ainda mais o fosso desigual no cenário pós pandemia mundial.
УИЛЬЯМ ШЕКСПИР КАК ЯВЛЕНИЕ МИРОВОЙ КУЛЬТУРЫ
Authors: Махмудова Л.А. , Ильясова Р.С.
Published: December 2020

В статье выделяются и описываются характерные особенности творчества великого поэта и драматурга У. Шекспира. Обосновывается мысль о том, что произведения Шекспира имеют глубинный философский смысл, благодаря которому его творчество оказало огромное влияние на мировую литературу последующих эпох. Автор приходит к выводу о том, что Шекспир хочет видеть человека свободным от предрассудков, готовым действовать и изменять мир. Темы и персонажи, которые он раскрыл в своих пьесах, на протяжении веков волновали многие народы и остаются актуальными сегодня.
ЛЕЧЕНИЕ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА И ПРИОБРЕТЕННЫХ ПОРОКОВ СЕРДЦА
Authors: Арсаханова Г.А.
Published: December 2020

В данной статье рассмотрены особенности, симптоматика, лечение ИБС и приобретённых пороков сердца.
(4-ARYLSULFAMOYL)PHENYLCARBAMIC ACID ESTERS II. SEARCH FOR A LEAD COMPOUND
Authors:   St Petersburg State Institute of Technology (Technical University), Krutikov Victor I. , Erkin Andrey V. ,   St Petersburg State Institute of Technology (Technical University)
Published: December 2020

Substituted phenylcarbamic acid alkyl esters were shown to be active against HSV-1 and HSV-2. Among them, 4-(2,6-dichlorophenylsulfamoyl)phenylcarbamic acid pentyl ester appeared to be the lead compound on the basis of Hansch and Free-Wilson QSAR methods. Optimization of the synthesis conditions of the above compound allowed obtaining a low toxic drug comparable to acyclovir in terms of antiherpes activity. The molecular docking study evidenced, that the potential target for the lead compound is thymidine kinase of herpes simplex viruses I and II.
DEVELOPMENT OF A HIGH-CONTENT ANALYSIS PROCEDURE FOR QUANTITATIVE DETERMINATION OF PROAPOPTOTIC ABILITY OF SMALL MOLECULE COMPOUNDS
Authors:   St Petersburg State Institute of Technology (Technical University), Romanova Angelina A. , Sagaidak Aleksandra ,   St Petersburg State Institute of Technology (Technical University), Lvova Milena Yu. ,   St Petersburg State Institute of Technology (Technical University), Grigoreva Tatiana A. ,   St Petersburg State Institute of Technology (Technical University)
Published: December 2020

The article presents the development of conditions for cell experiments using the Operetta CLS™ imaging system. The significance of high-content analysis parameters is substantiated. The optimal concentration and time parameters for the treatment of the cell culture of human colorectal carcinoma HCT116 by MDM2-p53 protein-protein interaction inhibitors were selected. The effect of the studied substances on cell growth was analyzed using Operetta CLS™.
PENENTUAN STATUS MUTU AIR DENGAN METODE INDEKS PENCEMARAN DI PERAIRAN PASIR PUTIH SITUBONDO
Authors: Pahlewi Anita Diah , Rahayu Herdiana
Published: December 2020

Kawasan pesisir Pasir Putih merupakan salah satu wisata bahari andalan Kabupaten Situbondo. Pengetahuan mengenai kualitas perairan Pasir Putih sangat penting untuk dilakukan.Penelitian ini bertujuan untuk mengetahui dan menentukan tingkat kualitas air sebagai gambaran kualitas perairan Pasir Putih. Pengambilan data kualitas air menggunakan metode insitu yaitu pengambilan data secara langsung di lapangan dan pengambilan data melalui pengujian di laboratorium. Analisa data hasil pengukuran parameter kualitas air yang didapatkan kemudian dihitung dengan metode Indeks Pencemaran. Perbandingan data hasil pengukuran parameter kekeruhan dan TSS dengan baku mutu untuk wisata bahari menunjukkan bahwa kekeruhan dan TSS nilainya tidak melebihi nilai standar baku mutu yang ditetapkan.Nilai pengujian pH, DO, BOD, dan fosfat berada pada rentang nilai yang diijinkan oleh standar baku mutu, kecuali nitrat yang melebihi nilai ambang batas baku mutu yang telah ditetapkan. Nilai Indeks Pencemaran Stasiun 1 sebesar 8.815; Stasiun 2 sebesar 7.943; Stasiun 3 sebesar 8.932; Stasiun 4 sebesar 8.656; Stasiun 5 sebesar 9.432; Stasiun 6 sebesar 9.178. Berdasarkan hubungan tingkat ketercemaran dengan kriteria Indeks Pencemaran dapat diketahui bahwa status mutu air Stasiun 1 hingga Stasiun 6 tercemar sedang karena 5,0 ≤ PIj ≤10.
TINJAUAN KUHAP TENTANG PENANGGUHAN PENAHANAN
Authors: Sugeng Tedjo Asmo
Published: December 2020

Studi penelitian ini membahas tentang bagaimana pelaksanaan penangguhan penahanan menurut KUHAP. Jenis studi penelitian ini adalah jenis normatif. Hasil studi penelitian ini menunjukkan bahwa pelaksanaan penangguhan penahanan dapat berupa jaminan orang atau uang. Dan pemberian penangguhan penahanan sewaktu-waktu dapat dicabut kembali sepanjang tersangka atau terdakwa dikhawatirkan melarikan diri atau melanggar persyaratan yang sudah ditentukan.
Obraz jako dobro wspólne. O filmie „Border” Laury Waddington
Authors: Mościcki Paweł
Published: December 2020

Artykuł stanowi dogłębną analizę filmu "Border" (2004) Laury Waddington. Autor przekonuje w niej, że artystyczna strategia zastosowana w tym dziele polega raczej na „dzieleniu obrazu” z uchodźcami niż na takiej lub innej formie ich reprezentacji. Interpretując różne wizualne efekty takiej procedury, autor ukazuje również jej polityczne i etyczne znaczenia.
NEW QUALITY OF HUMAN CAPITAL IN THE CONTEXT OF THE DIGITAL TRANSFORMATION OF THE ECONOMY
Authors:   Doctor of Economics, Professor, Head Department of Finance and Credit, Southwestern State University, Kursk, Russia, KOLMYKOVA T. S. , ZELENOV A. V. ,   Graduate student of Southwestern State University, Kursk, Russia
Published: December 2020

The article considers the theoretical aspects of the development of the fourth industrial revolution and digitalization of the economy and the role of human capital in the implementation of these processes. The periodization of technological development taking into account industrial revolutions is given. It is established that the new technological revolution and digitalization of the economy leads to a wide spread of end-to-end technologies. The study examined nine end-to-end technologies and identified problems of their statistical measurement and accounting. The analysis of the distribution of R&d volume and the number of patents for end-to-end digital technologies for 2011–2018 is carried out.
THE KNOWLEDGE ECONOMY AND THE REGULATORY GUILLOTINE
Authors:   Executive Secretary of the Expert Council on de-bureaucratization in the fields of education and science under the Committee on Science and Education of the State Duma of the Russian Federation, Director of the Institute for Digital Education Transformation, Moscow, Russia, BIKTIMIROV M. R. , SAFONOV M. S. ,   Professor of the Institute of Public Service and Management, Russian Presidential Academy of National Economy and Public Administration, Moscow, Russia
Published: December 2020

Last summer's parliamentary hearings “On measures to improve the quality of education in the Russian Federation” largely addressed the issues of reducing accountability and bureaucratic burden, reducing excessive control over the activities of teachers and heads of educational organizations. This resulted in an active discussion in the expert community of amendments to the draft Federal law on amendments to the relevant articles of the Federal law “On education in the Russian Federation”, as well as a discussion that is currently unfolding about the current problems of bureaucratization in the field of education and science, which this article is dedicated to.