bluuebunny/crossref_metadata_2025 huggingface dataset:
Zinc deficiency impairs functional recovery after spinal cord injury by promoting NF-κB activity in macrophages
Authors: Kijima Ken , Okada Seiji , Kobayakawa Kazu , Saiwai Hirokazu , Ono Gentaro , Hara Masamitsu , Yoshizaki Shingo , Yokota Kazuya , Saito Takeyuki , Tamaru Tetsuya , Iura Hirotaka , Haruta Yohei , Kitade Kazuki , Utsunomiya Takeshi , Konno Daijiro , Edgerton V. Reggie , Liu Charles Y , Sakai Hiroaki , Maeda Takeshi , Kawaguchi Ken-Ichi , Matsumoto Yoshihiro , Nakashima Yasuharu
Published: March 2023

Background
Spinal cord injury (SCI) is a devastating disease that results in permanent paralysis. Currently, there is no effective treatment for SCI, and it is important to identify factors that can provide therapeutic intervention during the course of the disease. Zinc, an essential trace element, has attracted attention as a regulator of inflammatory responses. In this study, we investigated the effect of zinc status on the SCI pathology and whether or not zinc could be a potential therapeutic target.
Methods
We created experimental mouse models with three different serum zinc concentration by changing the zinc content of the diet. After inducing contusion injury to the spinal cord of three mouse models, we assessed inflammation, apoptosis, demyelination and the number of nuclear translocations of NF-κB in macrophages by using qPCR and immunostaining. In addition, macrophages in the injured spinal cord of these mouse models were isolated by flow cytometry, and their intracellular zinc concentration level and gene expression were examined. Functional recovery was assessed using the open field motor score, a foot print analysis, and a grid walk test. Statistical analysis was performed using Wilcoxon rank-sum test and ANOVA with the Tukey-Kramer test.
Results
In macrophages after SCI, zinc deficiency promoted nuclear translocation of NF-κB, polarization to pro-inflammatory phenotype and expression of pro-inflammatory cytokines. The inflammatory response exacerbated by zinc deficiency induced more apoptosis of oligodendrocytes and demyelination at the lesion site, leading to worsened motor function compared to normal zinc condition. Furthermore, zinc supplementation after SCI attenuated these zinc-deficiency-induced series of responses and improved motor function.
Conclusion
We demonstrated that zinc affected motor functional recovery after SCI by negatively regulating NF-κB activity and the subsequent inflammatory response. Our findings suggest that zinc supplementation after SCI may be a novel therapeutic strategy for SCI.
Solving the “species bias” to facilitate orchid multi-scenario conservation planning in the south of the Hengduan Mountains
Authors: Wang Xue-Man , Tang Ying , Peng Xue-Feng , Wang Juan , Zhang Shi-Qi , Feng Yu , Peng Pei-Hao
Published: March 2023

detailed analyses of specific taxonomic groups at finer geographic scales to identify and prioritize biodiversity hotspots is a prominent method for optimizing conservation efforts, especially for the uneven species richness. The ecological suitability prediction and analysis of representative species provide vital references for conservation planning. Yet, in predicting suitability for multi-species or groups by species distribution models (SDMs) under a highly heterogeneous environment, species bias may occur cause of the unequal protection status and the spatial autocorrelation processing of occurrence data. For this, diversity, and protection hotspots were mapped in the south of the Hengduan Mountains, a significant site for global biodiversity. Specifically, creating a network of 1 km2 grid cells spanning the region, counting the orchid species, quantifying the protection value, and classifying attributes by the Jenks. And 5 km and 10 m buffer zone for each grid containing attributes compose the diversity and protection hotspot layers and were compared with the orchid suitability map modeled by SDMs. Results showed that even though there were extensively suitable habitats for orchids, the model results cannot completely cover whole the diversity and protection hotspots at any scale. Based on the map attributes, multi-scenario conservation planning was proposed. This study identifies the critical areas of suitability, diversity, and protection of orchids in this region, providing a meaningful reference for regional biodiversity conservation planning and producing a migrated method for biogeographic analysis in global biodiversity hotspots not just orchids. Besides, the results will supply crucial regional information for global biodiversity conservation.
Study of effects of biochar particle sizes on anaerobic co digestion of fecal sludge and food waste
Authors: Malimi Kilucha , Li Zifu , Cheng Shikun , Bishogea Obadia Kyetuza , Velempini Kgosietsile
Published: March 2023

The biochar addition to enhance anaerobic co-digestion (AD) of fecal sludge and food waste for methane production was investigated with a focus on biochar dosage and particle size of biochar. Optimal dosage range of biochar was determined as 5 - 20 g/l working volume based on lab-scale batch AD. Effects of biochar with different particle sizes at optimal dosage of 15 g/l were evaluated in a semi-continuous AD experiment, results of which showed that all the examined biochar’s with different particle sizes 0.075mm, 0.15mm and 0.45mm substantially enhanced the average methane yields (270ml/gVS, 241 ml/gVS and 222ml/gVS) compared to control digesters less than 200ml/gVS. The core reason for this phenomenon was that the biochar’s with different particle sizes had different properties i.e density, surface area and pore size and that the floating of large particle size of biochar was not conducive to microbial growth. Methane (CH4) in the biochar and control treatments were significantly different in all experiments. The results show that biochar added to digesters can significantly reduce H2S production with rising CH4 production.
Some new integral inequalities for s-convex functions of exponential type and their applications
Authors: Bakht Attazar , Anwar Matloob
Published: March 2023

In this paper, we propose and analyze the concept of s-convex function of exponential type, as well as some of its algebraic properties are discussed. In addition, for the newly suggested class of functions, we demonstrate several new integral inequalities of the Hermite-Hadamard (H-H) and well known Ostrowski type. Furthermore, we explore various variants of the H-H and Ostrowski type inequalities for a function whose first absolute derivative at a certain power is s-convex function of exponential type. In accordance with this newly proposed concept, we studied various applications of special means. We hope that the technique studied in this work will further spark the interest of interested scholars.
AMS Subject Classification: Primary 26D15; secondary 26A51
Inhibition of hepatic UGT1A1 attenuates bilirubin metabolism and aggravates liver fibrosis in schistosomiasis through the NF-κB signaling pathway
Authors: Xue Qingkai , Liu Yiyun , Hua Haiyong , Wang Yuyan , Zhu Tianyu , Hu Wenjun , Xu Yongliang , Zhang Ying , Xiong Chunrong , Liu Xinjian , Yang Kun , Huang Yuzheng
Published: March 2023

Background:Hepatic fibrosis is an important clinical manifestation of chronic schistosome infection. Patients with advanced schistosomiasis show varying degrees of abnormalities in liver fibrosis indicators and bilirubin metabolism. However, the molecular mechanism underlying the bilirubin metabolism abnormalities caused bySchistosoma japonicuminfection remained unclear. Meanwhile, the role of bilirubin in our body is controversial, and the interaction between bilirubin and hepatocytes remains to be further studied.Methods:Blood samples from advanced schistosomiasis patients in Jiangsu province were collected for clinical blood biochemical examination according to standard procedures, and descriptive analysis and correlation analysis were performed for bilirubin and liver injury-related indicators. The mechanisms of bilirubin metabolic changes were explored by establishing a mouse model ofSchistosoma japonicuminfection combined with experiments of in vitro and spatial metabolomics techniques. Bilirubin regulation of hepatic fibrosis-related signaling pathways was further investigated in vitro.Results:Abnormal bilirubin metabolism was found in 23.35% of advanced schistosomiasis patients in Jiangsu Province. In the infection mouse model, liver fibrosis increased with infection time, whereas liver UGT1A1 showed continual low expression and an associated with impaired bilirubin metabolism in mice. Meanwhile, we found that uridine, a key substance associated with bilirubin metabolism in schistosome infection, was identified through spatial metabolomics techniques. In vitro experiments suggested that soluble egg antigen may be a key inhibitor of hepatic UGT1A1 expression after schistosome infection. In addition, the relationship between the abnormal increases in bilirubin and hepatic fibrosis in patients with schistosomiasis was unclear. We observed a positive correlation between abnormal bilirubin metabolism and abnormalities in ALT, AST, LN, and CIV in patients with advanced schistosomiasis. Moreover, high concentrations of bilirubin activated the NF-κB signaling pathway in L-O2 hepatocytes in vitro.Conclusions:The impaired bilirubin metabolism due to low expression of UGT1A1 caused bySchistosoma japonicuminfection may play an important role in schistosomiasis liver fibrosis through the NF-κB signaling pathway.
Subcutaneous implantation of nodular goiter after endoscopic thyroidectomy: a case report
Authors: Fan Li , Yang Lei , Huang Yun-Hui , Chen Mao-Shan , Yang Hong-Wei
Published: March 2023

Background
Nodular goiter is a common benign tumor in clinical practice, it refers to a simple diffuse goiter due to repeated progression, causing follicular epithelium to diffuse into focal hyperplasia and degeneration in parts. Finally, because of long-term hyperplastic lesions and degenerative diseases, alternately repeatedly gland nodules in different stages of development, which is essentially a benign lesion and there are few reports confirming metastasis.
Case presentation:
The patient was a 26-year-old female with a history of right lobe subtotal thyroidectomy for thyroid nodules one year prior. Postoperative pathological examination revealed a nodular goiter with cystic changes in the "right lobe thyroid tumor". This time, she was admitted to the hospital because of the discovery of bilateral neck mass for one month. Physical examination: multiple protruding masses were seen in the neck, and the largest mass was located on the right side of the neck with a length of about 2 cm. Ultrasound showed multiple isoechoic nodules were found bilaterally in the neck, most of which were located in the sternocleidomastoid muscle. CT scan of the neck showed multiple nodules below the right lobe of the thyroid and in the front of the neck, and thyroid implantation lesions were considered. During the last operation, it was confirmed that the mass was scattered and mostly not in the area of the previous operation, and the pathological diagnosis was consistent with nodular goiter.It is thought to be caused by distant metastasis of a benign tumour and this is a very rare case.
Conclusions
This case report suggests that nodular goiter, as a benign lesion, may also present with implantation or metastasis, which should be considered in clinical practice, Surgeons need to prevent nodular goiter implantation during surgery.
A geometric characterization of cyclic p-gonal surfaces
Authors: Gallo Daniel M.
Published: March 2023

A closed Riemann surface $S$ of genus $g\geq 2$ is called {\it cyclic p-gonal} if it has an automorphism $\rho$ of order $p$, where $p$ is a prime, such that $S/\langle\rho\rangle$ has genus $0$. For $p=2$, the surface is called hyperelliptic and $\rho$ is an involution with $2g+2$ fixed points. Classicaly, cyclic p-gonal surfaces can be characterized using Fuchsian groups. In this paper we establish a geometric characterization of cyclic p-gonal surfaces. Specifically, this is determined by collections of simple geodesic arcs on the surfaces and graphs associated to these arcs. In previous work, the author has given a geometric characterization of hyperelliptic surfaces in terms of simple, closed geodesics and graphs associated to these. The present work may be seen as an extension. Involutions, however, have properties that do not generalize to arbitrary automorphisms of order $p$. Hence, the number of vertices needed in the graphs used here is larger than that of the hyperelliptic case.
2010 Mathematics Subject Classification: Primary 30F45; Secondary 30F10
The Effect of the Ganglionic Segment Inflammatory Response to Postoperative Enterocolitis in Hirschsprung Disease
Authors: Benibol Yalım , Onenerk Mine , Hakalmaz Ali Ekber , Comunoglu Nil , Tekant Gonca , Özcan Rahşan
Published: March 2023

Purpose: We examined the relationship between inflammatory reactions in the intestine in Hirschsprung's disease (HD) and Hirschsprung-associated enterocolitis (HAEC).
Methods: There were 30 cases (M:27, F:3) who were operated with the transanal endorectal pull-through (TERP) method for HD between 2012 and 2022. The cases were divided into three groups. Group 1: Cases with preoperative and postoperative enterocolitis, Group 2: Cases with postoperative enterocolitis, Group 3: Cases with preoperative enterocolitis. The intestinal segments removed during the surgery were evaluated for interleukin 1 beta (IL-1ß), tumour necrosis factor alpha (TNF-α), and interleukin 6 (IL-6).
Results: In the compression of enterocolitis groups and control group, the average intensity of IL-ß staining percentages in lamina propria(LP) were 52,2±23,8% to 17,8±25,4% and in epithelium 50±23,6% to 22,1±24,6%. Those for TNF-α score of LP staining were 65,4±24% to 47,1±24,2%. It has been found that an increase of IL-1ß intensity in LP(p:0.002) and epithelium(p:0.014) of the positive ganglion side is related to enterocolitis. However, a similar relationship for TNF-α was found in only transitional zone LP(p:0.01).
Conclusion: It has been shown that endogenous TNF-α secretion and IL-1β-related inflammation play a role in the etiology of HAEC. It has been thought that HAEC is not just an infective disease but an autoinflammatory process.
An alternative technique for fitting the gravimetric geoid for Egypt
Authors: Abd-Elmotaal Hussein , Makhloof Atef
Published: March 2023

In this paper, a proposed geoid fitting technique for Egypt's physically determined geoid and GPS/leveling-derived geoid is introduced. First, any errors in the available GPS benchmarks are ruled out. The method relies on the absolute geoid difference, which is the physical geoid minus the geoid obtained through comparing GPS and levelling. The suggested geoid fitting technique uses an optimization algorithm scheme to choose the minimum number of the best-suited GPS benchmarks to be used for fitting the physical geoid. The least-squares prediction method is used to determine each GPS point's impact on the remaining GPS points. The subset of GPS points are used for external validations including the GPS point with the least impact on the other points, till an acceptable limit of the influence of the GPS points on the remaining ones. This step is repeatedly iterated, where the number of available GPS points is reduced by one each time. Also, the results of the first iteration are introduced. The proposed geoid fitting technique is compared with that using polynomial regression of different degrees. The results proved that, the proposed technique gives extremely better results.
Measuring Self-Objectification in Cisgender Heterosexual Women and Men: A Psychometric Validation of Three Widely Used Self-Objectification Scales
Authors: Hu Zhuozhuo , Wood Chantelle , Buckland Nicola J
Published: March 2023

A large body of literature demonstrates that self-objectification can harm individuals’ body image. However, measures of self-objectification are primarily designed for women and have not been adequately validated in men. This research investigated the psychometric properties of the Self-Objectification Questionnaire (SOQ), the Objectified Body Consciousness Body Surveillance Scale (OBC-Surv), and the Self-Objectification Beliefs and Behaviors Scale (SOBBS) in cisgender heterosexual women and men. Study 1 (women = 180, men = 163) and Study 2 (women = 137, men = 138, age-representative samples) used an online longitudinal study design, with a follow up after two weeks to assess test-retest reliability. While the SOQ, OBC-Surv and SOBBS generally displayed satisfactory psychometric properties in women, only the OBC-Surv and SOBBS displayed satisfactory psychometric properties in men. In addition, while women scored significantly higher on the SOQ, OBC-Surv, SOBBS Factor 1 and SOBBS Total in both Studies 1 and 2, sexual objectification experience only adequately accounted for gender-differences in scores on the SOBBS, and not the SOQ or OBC-Surv. To confirm that the SOBBS is appropriate for measuring and comparing self-objectification across women and men, Study 3 reanalysed the data from Study 2 to examine measurement invariance. This analysis demonstrated measurement invariance of the SOBBS between women and men. Accordingly, the SOBBS is recommended for measuring and comparing self-objectification in women and men. Future research should further examine the psychometric properties of the SOBBS in men and potential explanations of gender-differences in scores on the OBC-Surv.
Effects of Cosmic Dislocation on Non-Relativistic Quantum Particles with Interaction Potential and Thermodynamic Properties
Authors: AHMED FAIZUDDIN
Published: March 2023

In this work, we investigate the quantum dynamics of non-relativistic particles interact with potential in the background of a linear topological defect produced by cosmic string spacetime. We choose anharmonic oscillator potential and solve the wave equation using the parametric Nikiforov-Uvarov method and determine the exact solution of the quantum system. We show that the eigenvalue solution is influenced by the topological defects and get shifted compared to the flat space results with this potential. Finally, we study the thermodynamic properties of the quantum system and calculate the partition function and other thermodynamic quantities, such as the vibrational free energy, mean free energy, specific heat capacity, and entropy of the system at finite temperature T ≠ 0 and analyze the effects on them
PACS 03.65.Pm · 03.65.Ge · 98.80.Cq · 02.30.Gp · 05.70.C
At Eighty-Two: A Book Review
Authors: Freeman Amy
Published: March 2023

Above all else, the substantive presence of poignancy created by her awareness of the failure to receive acceptance by her peers and the critics permeates the entire journal.
Double Discrimination: An Examination of the Career Destinations of Muslim Women in Britain
Authors: Parker-Jenkins Marie , Irving Barrie , Khan Shazia
Published: March 2023

For most Muslim women, it is these changing circumstances, this ebb and flow in the fortunes of Muslim communities that they have had to negotiate and which the young generation of Muslim women growing up in this country are now confronting. This generation of respondents perceived that there is a lack of comprehension by the older generation of the teachings of the Qu'ran. They believe that this older generation is bound by culture rather than religion while they themselves, are more educated and aware of the 'precise' teachings of Islam.
Improving Equity through a Science Enrichment Program
Authors: Ferreira Maria M. , Patterson Chinequa Monique
Published: March 2023

We examined the impact of science enrichment activities on African American female students' achievement and attitude towards science. Seventeen students participated in the study. Attitudes were measured using a pre and post attitudinal survey, whereas achievement was measured using test scores from their biology class over a six-week period. Pre- and post measures indicated a significant increase in achievement and attitudes for the students who participated in the study.
Representation of Women in Top Educational Management and Leadership Positions in Kenya
Authors: Amondi Osumbah B.
Published: March 2023

The purpose of the study was to investigate factors causing under representation of women in top educational management and leadership positions at the Ministry of Education headquarters in Kenya. Descriptive survey design, utilizing quantitative and qualitative approach was used in the study. Stratified random sampling was used to categorize the target population of 161 educational personnel by level of management and gender. Simple random sampling was then used to get a study sample of 76 officers. Questionnaire and interview guide were used to gather information from the respondents. Analysis of staff returns documents was done to get the numerical representation of the personnel by gender. Data were analyzed using descriptive statistics such as percentages, frequency distribution, mean scores, and standard deviations. The findings showed that 33.3 percent and 32.1 percent of top and middle management positions respectively were held by women. In terms of professional qualifications, 55 percent and 51.5 percent of M.Ed and B.Ed holders respectively, were women. Both male and female genders were rated "˜high' in possession of skills and personality characteristics the respondents considered important for top educational management and leadership positions. Organizational factors were the strongest barriers for women in ascending to top educational management and leadership positions. This was followed by socio-cultural and the least were individual factors. Strategies to improve the representation of women in top educational management and leadership therefore focused on the girl child in school, women themselves, society, government policies, the Education Act and the country's constitution
Interactive effects of salicylic acid and jasmonic acid on secondary metabolite production in Echinacea purpurea
Authors: RASOLİ Fatemeh , GHOLİPOOR Manoochehr
Published: March 2023

Secondary metabolites are highly beneficial to human health and have commercial and industrial values. So, this research aimed to study the effects of exogenous salicylic acid (SA) and jasmonic acid (JA) on some secondary metabolites in purple coneflower. A field experiment as a randomized complete block design with three replications was conducted in Shahrood, Iran. Treatments were the factorial arrangement of 3 SA (0, 0.5, and 1 millimole) and 4 JA concentrations (0, 5, 20, and 50 micromole). The non-linear regression procedure was employed to quantify the relation of these materials with each other. The results indicated that the SA effect on all ten measured secondary metabolites changed with changing the JA levels as there was the interaction between these elicitors. On average, most (7 out of 11) of the combined SA_JA levels up-regulated the production of secondary metabolites as compared to the plants not sprayed with SA and JA. In terms of average response to elicitation with 11 combined SA_JA levels, they ranked from higher to lower as the guaiacol peroxidase, hydrogen proxide (H2O2), polyphenol oxidase, glutathione S-transferase, superoxide dismutase, NADPH oxidase, total phenolic content, phenylalanine ammonia-lyase, anthocyanin, and flavonoid. A few secondary metabolites appeared to have a biphasic relationship with each other. For instance, over lower and medium values of NADPH oxidase activity, anthocyanin content increased linearly with increasing NADPH oxidase activity; over higher values of NADPH oxidase activity, it showed a plateau state.
Topological transitions in weakly monitored free fermions
Authors: Kells Graham , Meidan Dganit , Romito Alessandro
Published: March 2023

We study a free fermion model where two sets of non-commuting
non-projective measurements stabilize area-law entanglement scaling
phases of distinct topological order. We show the presence of a
topological phase transition that is of a different universality class
than that observed in stroboscopic projective circuits. In the presence
of unitary dynamics, the two topologically distinct phases are separated
by a region with sub-volume scaling of the entanglement entropy. We find
that this entanglement transition is well identified by a combination of
the bipartite entanglement entropy and the topological entanglement
entropy. We further show that the phase diagram is qualitatively
captured by an analytically tractable non-Hermitian model obtained via
post-selecting the measurement outcome. Finally we introduce a
partial-post-selection continuous mapping, that uniquely associates
topological indices of the non-Hermitian Hamiltonian to the distinct
phases of the stochastic measurement-induced dynamics.
The budget policy of Ukraine under martial law
Authors: Chugunov Igor , Makohon Valentyna , Titarchuk Mykhailo , Кrykun Tetiana
Published: March 2023

Large-scale military actions on Ukraine’s territory have led to extraordinary challenges for budget policy. This study aims to evaluate the budget policy of Ukraine and substantiate its strategic priorities in martial law. The paper used economic and statistical methods to assess the ultimate budget indicators. It was determined that budget revenues decreased due to the economic recession, and expenditures, primarily for defense and security, increased. In 2022, compared to 2021 (the full-scale war against Ukraine began on February 24, 2022), tax revenues decreased by 7.6%. In contrast, the study observed an increase in budget expenditures by 65.0%, in the budget deficit by 4.5 times (financed mainly by external borrowings and military bonds bought by the National Bank of Ukraine), and in state and guaranteed state debt by 52.4%. In the context of military operations, the budget policy aims to ensure a balance between financing the most critical items of the budget and stimulating the economy’s recovery. At the same time, the institutional capacity of state authorities allows controlling how a country survives in this challenging period. In order to restore the economy, the Ukrainian government must implement a prudent budget policy, assess fiscal risks associated with changes in the macroeconomic environment, and increase the efficiency of budget expenditures.
Effect of inbreeding on the occurrence of genetic defects in Chinese Crested dogs
Authors: BARTNIKOWSKA AGNIESZKA , KANIA-GIERDZIEWICZ JOANNA
Published: March 2023

The aim of the study was to analyse the impact of inbreeding on the frequency of hereditary diseases and the number of genetically tested dogs. The pedigrees of 100 Chinese Crested dogs from Polish Kennel Club and information about genetic tests for hereditary eye diseases and other veterinary diagnoses were collected. Inbreeding coefficients and relatedness were estimated for all dogs examined. The relationship between the level of inbreeding and genetic testing was analysed with logistic regression. The relationship between the occurrence of eye disease carriers and sex or the level of inbreeding was also tested. A significant relationship (P < 0.01) was found between inbreeding and the number of animals genetically tested for PLL eye disease. The effect of sex or the level of inbreeding on the eye disease carrier status was non-significant (P > 0.05). However, in some inbred animals the status of the eye disease carrier could be connected with inbreeding, although this needs further research. We found that most of the dogs had related parents and genetic defects. We also found that the breeders often used related dogs, which reduced the genetic diversity of the group and caused hereditary diseases. We suggest that Chinese Crested dog breeders be more open about publishing DNA-test results, which is fundamental for the health of the breed.
On some probability distributions, related to the classical Bernoulli scheme. II
Authors:   St. Petersburg State University, Ananjevskii Sergey M. , Nevzorov Valery B. ,   St. Petersburg State University
Published: March 2023

The classic scheme of independent trials by Bernoulli has been one of the most popular topics in probability theory for more than three centuries, starting with the work of Jacob Bernoulli. It is ideal for setting and solving various practical problems. Many results have been obtained related to modifications of this scheme, but new situations, new problems appear that require further progress in the study of various random variables related to one degree or another with independent Bernoulli tests. In this paper, we continue to study some problems related to the series of successes and failures in sequences of Bernoulli random variables (c. v.). This work is a direct continuation of the authors’ article “On some probability distributions related to the classical Bernoulli scheme”, published in 2022.
Isosceles tetrahedron and an equimomental system of a rigid body
Authors:   Federal Research Center “Computer Science and Control” of the Russian Academy of Sciences, Nikonova Ekaterina A.
Published: March 2023

The problem of equimomental systems of a rigid body is considered. It is shown that the system of four equal masses located at the vertices of an isosceles tetrahedron is equimomental to a given rigid body. A system of material points of equal masses located at the vertices of an isosceles tetrahedron, which is equimomental of cometary nuclei of 67P Churyumov-Gerasimenko, has been constructed.
What is the age of the Udzha paleorift?: U-Pb age of detrital zircons from Udzha basin terrigenous succession, northern Siberia
Authors:   St. Petersburg State University, Malyshev Sergey V. , Pasenko Alexander M. ,   Schmidt Institute of Physics of the Earth of the Russian Academy of Sciences, Khudoley Andrei K. ,   St. Petersburg State University, Ivanov Alexei V. ,   Institute of the Earth’s Crust of the Siberian Branch of the Russian Academy of Sciences, Priyatkina Nadezhda S. ,   Institute of Geology and Geochronology RAS, Pazukhina Anna A. ,   St. Petersburg State University, Marfin Alexander E. ,   Institute of the Earth’s Crust of the Siberian Branch of the Russian Academy of Sciences, DuFrane Andrew S. ,   University of Alberta, Sharygin Igor S. ,   Institute of the Earth’s Crust of the Siberian Branch of the Russian Academy of Sciences, Gladkochub Egor A. ,   Institute of the Earth’s Crust of the Siberian Branch of the Russian Academy of Sciences
Published: March 2023

The Udzha paleorift is located between the Anabar and Olenek rivers and is a key structure indicative of the breakup of the Nuna supercontinent. However, the age of initiation and duration of paleorift activity is not defined nowadays. Here we present new U-Pb data for detrital zircons from two terrigenous and volcanic-sedimentary successions of the Udzha sedimentary basin (Unguokhtakh and Udzha Fm), from terrigenous rocks overlying the Udzha basin (Tomtor Fm), and from the sandstone of the lower Mesoproterozoic Mukun Group in the northwest part of Anabar region. The dating results show that sedimentation in the Udzha rift basin began later than ca 1459 Ma, and the duration of the rift activity is estimated as not longer than 73 My. The Udzha rift basin was an isolated basin in the northern part of Siberia, and detrital material came from local sources. A previously unknown source for tuff-sandstone of Unguokhtah Formation with an age of 1850 Ma has been identified, which corresponds by age to the Paleoproterozoic post-orogenic magmatism of the Siberian Craton. In the Neoproterozoic, detrital material of the Tomtor Fm was supplied from the northeast, and the sources were igneous suites of active margin or collision settings. The maximum depositional age of Tomtor Fm is estimated as 565 Ma on the youngest zircon population, which suggests an over 800 Ma gap in sedimentation in northern Siberia in Meso- Neoproterozoic.
New geochemical and isotopic (Rb-Sr and Sm-Nd) data for the rocks of the alkali-ultrabasic massif Kondyor of the Aldan Shield (Khabarovsk Territory, Russia)
Authors:   Institute of Geology and Geochronology, Russian Academy of Sciences, Savatenkov Valery M. ,   St. Petersburg State University, Mochalov Alexander G. ,   Institute of Geology and Geochronology, Russian Academy of Sciences
Published: March 2023

The chemical composition and Rb-Sr and Sm-Nd isotope characteristics of various rocks that make up the alkali-ultramafic Kondyor massif of the Aldan Shield were studied: dunites, clinopyroxenites, gabbro, kosvites, alkaline syenites. Ultrabasic rocks of the early stage (dunites, clinopyroxenites) have a significant metasomatic alteration associated with the intrusion of a dike complex of alkaline rocks. The petrochemical features of dunites and clinopyroxenites indicate that these rocks are cumulative phases that successively crystallized from picritic melt at an early stage of the formation of the massif. Gabbro and kosvites of the marginal series were formed from the residual melt after the crystallization of dunites and clinopyroxenites. The Rb-Sr and Sm-Nd isotopic characteristics in the rocks of the early intrusion stage (dunites, clinopyroxenites, gabbro) indicate that these rocks were formed with the participation of the host rock contamination processes. The isotope-geochemical characteristics of the rocks of the dike complex (kosvites and alkaline rocks of the dunite core) indicate that these rocks crystallized from a deep melt that was not significantly contaminated by the continental crust. Differences in isotopic characteristics between ultramafic rocks and rocks of the dike complex of the dunite "core" - kosvites and alkaline rocks, suggest at least two sources of melts that participated in the formation of the Konder massif: (1) an early, deep-seated melt that formed ultrabasic rocks at the upper level, and also kosvites, plagioclase pyroxenites and gabbro of the outer “ring” with a significant degree of contamination; (2) late, differentiated (monzonite and alkaline-syenite) deep-seated melt (far from the contaminant) that became the source of kosvite and alkaline rock dikes in the central part of the Konder massif.
Petrological model for formation of felsic volcanic rocks of the Pecherkinskaya Formation (northwestern part of the Salair Ridge)
Authors:   Sobolev Institute of Geology and Mineralogy SB RAS, Vetrova Natalia I. , Vetrov Evgeny V. ,   Sobolev Institute of Geology and Mineralogy SB RAS, Letnikova Elena F. ,   Sobolev Institute of Geology and Mineralogy SB RAS
Published: March 2023

The geochemical and isotopic (Nd, Sr) characteristics of felsic volcanic rocks of the Pecherkinskaya Formation in the northwestern part of the Salair Ridge were studied. These rocks are closely associated with industrially significant deposits and manifestations of gold- and silver-bearing pyrite-polymetallic formations with potentially gold-bearing weathering crusts on them. The study of the material composition of unaltered volcanic rocks of the Pecherkinskaya Formation is necessary for the reconstruction of the conditions of their formation, which contributes to estimation of the mineragenic potential of this formation and the conditions during the accumulation of ore matter. Felsic volcanic rocks of the Pecherkinskaya Formation are an extreme member of the basalt-plagioryolite series, have an extremely high-sodium type of alkalinity with a low potassium content, are calcareous and characterized by high silica contents, low iron content, have low REE concentrations, are enriched in Pb and U and depleted in Ta and Nb, are characterized by high values of εNd (t) (+6.36) and primary ratio 87Sr / 86Sr (0.706977). The REE distribution spectra show a low degree of fractionation with a pronounced negative "europium anomaly". The geochemical composition of the Pecherkinskaya Formation volcanic rocks indicates that primary magmas were formed by partial melting of rocks of the lower continental crust at a pressure of ~ 8 kbar in equilibrium with Hbl + Cpx + Pl ± Opx restite and a temperature of ~ 750-790 ° C. The isotope-geochemical characteristics indicating the participation of depleted mantle in the source are probably inherited from the juvenile crust, the rocks of which could have been formed as a result of differentiation of mantle magmas. Geological and geochemical features of felsic volcanic rocks of the Pecherkinskaya Formation are characteristic of igneous rocks formed under conditions of oceanic arcs.
Growth poles in the Krasnoyarsk region: methods of identification and concentration of effects
Authors:   Lomonosov Moscow State University, Demidova Ksenia V. , Makushin Michael A. ,   Lomonosov Moscow State University
Published: March 2023

The article examines the geographical distribution of economic effects from the implementation of large projects in the Krasnoyarsk region: municipalities are distinguished – growth poles and poles of acceptance of growth effects. Based on the Moran index and the volume of investments in fixed assets calculated for the municipalities of the Krasnoyarsk region, the municipalities – growth poles are identified, local specialization and specifics of projects are analyzed, as well as the impact of these factors on economic growth. Poles of acceptance of effects are allocated on the basis of the number of firms with "production" OKVED per capita, and also classified in accordance with the dynamics of direct and indirect effects manifested in the territory of the municipality. The geographical separation of the poles of acceptance of effects from the growth poles is noted. If the growth pole and the pole of acceptance coincide geographically, then this is a consequence of solving the related tasks of the project (for example, logistics) and does not contribute to the development of the local economy. The economic effects of the implementation of projects for the municipalities of the Krasnoyarsk region are minimal, and mainly affect only the transport, construction, and partly trade industries. More than 90% of the effects from the implementation of projects are concentrated in Krasnoyarsk, since the largest transport and construction companies in the region are registered here, and the main capacities of the manufacturing industry are located. A single and relatively small impact of projects is manifested for small industrial cities of the Krasnoyarsk region (Divnogorsk, Nazarovo), but the projects being implemented do not become an additional growth factor for cities. The level of concentration of firms with "production" OKVED allows us to identify large centers – potential poles of acceptance of effects, but does not guarantee that they are able to master this potential during the implementation of large projects.
Routine use of mobile electronic devises by schoolchildren and students and its correction by hygienic education
Authors:   Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation, Milushkina O.Yu. , Skoblina N.A. ,   Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation, Pivovarov Yu.P. ,   Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation, Markelova S.V. ,   Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation, Mettini E. ,   Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation, Ievleva O.V. ,   Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation, Tatarinchik A.A. ,   Pirogov Russian National Research Medical University, 1 Ostrovityanova Str., Moscow, 117997, Russian Federation
Published: March 2023

Many research works have described negative effects produced by use of electronic devices, mobile ones (smartphone, tablets) included, on children, adolescents and youth. However, the problem has many aspects and not all of them have been explored profoundly. In this study, our aim was to conduct hygienic assessment of routine use of mobile electronic devices by schoolchildren and students and to give grounds for its correction by hygienic education. By conducting a survey, we obtained data on use of mobile electronic devices by 1218 schoolchildren and students both in their educational and spare time activities and created a profile of a work and rest routine when working with mobile electronic devices. 943 students and schoolchildren were examined by an ophthalmologist. Next, issues related to hygienic education were integrated into the training program for medical students at the Hygiene Department of the Pirogov Russian National Research Medical University. The emphasis was on creating a safe routine of using mobile electronic devices. Schoolchildren and students who adhered to a healthy work and rest routine when working with mobile electronic devices complained about health disorders authentically less frequently (p ≤ 0.05).We established a statistically significant relative risk for visual acuity if schoolchildren and students did not pursue a safe routine of using mobile electronic devices. Its level was RR = 3.07 (95 % CI =1.88–5.03). By the end of hygienic studies with their focus on creating a safe routine of using mobile electronic devices, medical students had an authentic (p ≤ 0.05) increase in visual acuity due to decline in such states as routine accommodative excess and pre-myopia. Work and rest routines accepted by children, adolescents and youth when they use mobile electronic devices are a manageable risk factor of health disorders in these population groups. This study shows that hygienic education may be quite effective for correcting a routine of using mobile electronic devices by schoolchildren and students.
Dawid as a Prophet in the Targum Jonathan to the Books of Samuel
Authors: Napiwodzki Dawid
Published: March 2023

The main purpose of this article is to portray King David as a prophet in the Targum Jonathan to the Books of Samuel. We first analyze the question where and how David’s prophetic character is shown implicitly in the texts of the Hebrew Bible. We also ponder when the concept of David as a prophet was born. Against this background, the paper analyzes the pericopes in the Targum Jonathan to the Books of Samuel that explicitly mention David as a prophet (TgJ 2 Sam 18:3; 22:1–51; 23:1–7). The targumist’s alteration of the Masoretic Text was intended not only to portray David as a prophet, but also to reinforce the authority and stature of his statements.
Ideological and Intertextual Relations Between the Targum Isaiah and the Gospel of John
Authors: Wróbel Mirosław
Published: March 2023

In this article, the author asks whether there are ideological and intertextual connections between the Targum Isaiah and the Gospel of St. John, and whether the traditions contained in the targums could have influenced the teaching of Jesus of Nazareth and the Apostles. The targums are first shown in their Jewish and Christian contexts. The author then turns his attention to the reception and significance of the book of Isaiah for the Jewish community and for the Johannine community. In particular, he emphasizes the use of this book in the synagogue liturgy and in the Gospel of John. The author also shows new interpretive perspectives for selected Johannine texts in light of the texts contained in the Targum Isaiah. He analyzes the Memra–Logos relationship, the messianic identity of the Johannine Jesus, the significance of Abraham in relation to the sons of Israel, the significance of God’s glory, the identity of YHWH’s suffering Servant, Jesus as the New Temple, and the use of the ego eimi formula in an absolute form. He encourages further detailed research on the influence of targumic traditions on the teaching of Jesus and on the Christology of the Fourth Gospel.
HIGH-INTENSITY LASER THERAPY TO TREAT NEUROPATHIC PAIN IN POST-HERPETIC NEURALGIA
Authors: Suherlim Richard , Widyadharma I Putu Eka , Adnyana I Made Oka , Suryapraba Anak Agung Ayu
Published: March 2023

Post-herpetic neuralgia (PHN) is chronic neuropathic pain that is felt for at least 3 months or more at the site of the rash due to herpes zoster infection. Epidemiological studies get a prevalence of 0.49 cases of PHN per 1000 people per year. The clinical manifestation of PHN is chronic pain on the skin lesions due to herpes zoster infection. The therapy that is commonly used as the first line is the provision of pharmacotherapy such as gabapentin or pregabalin. An 83-year-old male patient with a diagnosis of PHN that had been felt for 5 years. He has been taking drugs for 5 years but the pain has not improved. The patient is given high-intensity laser therapy. After 5 treatments with an interval of 1-2 weeks, pain was significantly reduced from an 8/10 scale to 4/10. The frequency of occurrence of severe pain is also reduced from 5 times per day to only 1 time per day. The use of high-intensity laser therapy is not commonly used as a therapy for PHN. Based on its mechanism of action, the use of high-intensity laser therapy is worth considering because of its effectiveness in treating pain in a shorter time than low-intensity laser therapy.
RAMSAY HUNT SYNDROME: A CASE REPORT
Authors: Dwitasari Made Ayu Dessy , Seputra Desak Made Cittarasmi Saraswati
Published: March 2023

Ramsay Hunt Syndrome (RHS) is a rare disease caused by reactivation of latent Varicella Zoster Virus in the geniculate ganglion which lead to inflammation, edema, and compression of facial nerve. RHS may affect both immunocompetent and immunocompromised patient. Clinical manifestation of RHS include herpes zoster oticus that manifest as vesicular rash on auricular area or oral mucosa in combination with peripheral nerve palsy. We reported a 67-years-old female patient with herpetic vesicle on left side of face and ear accompanied with ipsilateral peripheral facial paralysis since 2 days before admission. Patient was treated with acyclovir for 5 days. Follow up examination showed satisfying clinical improvement with disappearance of vesicles and otalgia, as well as facial weakness improvement from House Brackmann grade III to grade II. Early recognition and treatment of Ramsay Hunt Syndrome is crucial as delay of treatment may lead to sequelae, including postherpetic neuralgia and permanent facial paralysis.
GRAPE SEED EXTRACT’S NEUROPROTECTIVE EFFECT AND PARKINSON’S DISEASE: A SYSTEMATIC REVIEW
Authors: Fandy Sharon Jessica
Published: March 2023

Parkinson’s disease (PD) is the most common neurological disease globally, only second to Alzheimer’s disease. One of the emerging treatments for PD is nutraceuticals. Grape seed extract (GSE) has a high concentration of polyphenolic compounds possessing antioxidant and neuroprotective capacity that may be valuable for neurodegenerative diseases. So far, there is no review summarizing the neuroprotective effect of GSE on PD, even though it is crucial to provide an insight into GSE as a potential natural treatment for PD. This systematic review aims to summarize the neuroprotective effect of grape seed extract (GSE) in Parkinson’s Disease in vivo and in vitro and their mechanism. The author performed a literature search using PubMed, Science Direct, Scopus, Sinta, and Garuda databases with keywords comprising “Neuroprotective”, “Grape Seed,” and “Parkinson’s disease.” Out of 1611 studies retrieved, 20 articles fit the inclusion criteria and became the basis for this review. The author analyzed and extracted the records regarding the neuroprotective effect and potential anti-PD properties from the studies. The analysis summarized that GSE could significantly improve the biological hallmarks of PD with numerous mechanisms, including antioxidant, anti-inflammation, protection of dopaminergic neurons, anti-amyloid effect, anti-apoptotic, neurogenesis, and synaptogenesis. Although the precise mechanism underlying PD is still elusive, treatment should target not only a single cause of PD but instead several pathways that could lead to the disease. In conclusion, GSE should be considered a potential nutraceutical in clinical trials to prevent and alleviate Parkinson’s disease by multiple mechanisms.