bluuebunny/crossref_metadata_2025 huggingface dataset:
INVESTIGATION OF THE GLOBAL OUTCOMES OF ACUTE RESPIRATORY DISTRESS SYNDROME WITH THE EFFECT OF COVID-19 IN PUBLICATIONS: A BIBLIOMETRIC ANALYSIS BETWEEN 1980 AND 2020
Authors: ZENGİN Musa , BALDEMİR Ramazan
Published: August 2021

Objective: Acute respiratory distress syndrome (ARDS) is regarded as a serious complication with high mortality rates and constitutes an important health problem during the COVID-19 pandemic. Therefore, a thorough bibliometric study on ARDS is needed. In this study, it was aimed to holistically summarize the articles published on ARDS between the years 1980 and 2020 using statistical methods and bibliometric analyses.Material and Methods: The literature was scanned using the Web of Science (WoS) database. Keywords used on WoS included “acute respiratory distress syndrome”, “adult respiratory distress syndrome” and “ARDS”. The search was carried out on the “titles” of the publications, and the articles obtained were bibliometrically analyzed. Linear and non-linear regression analysis was used in order to estimate the number of future studies.Results: A total of 11.934 publications were found. Of these publications, 5402 were articles (45.3%) on which the bibliometric analysis was performed. A high increase trend was observed in the number of publications during COVID-19. Most articles were published in the field of Critical Care Medicine (1965, 36.4%). The top four countries contributing to the literature were the USA (1967, 36.4%), Germany (534, 9.9%), France (534, 9.9%), and China (534, 9.9%). The most active 4 institutions were confirmed as theUniversity of Toronto (154), University of California San Francisco (153), University of Washington (153) and University of Harvard (151). The first 2 journals with the most publications were Critical Care Medicine (394) and Intensive Care Medicine (248).Conclusion: In this comprehensive bibliometric study on ARDS on which the number of research increases day by day with the effect of the COVID-19 pandemic, a summarized information of 5402 articles published between 1980 and 2020 was reported. This study will be a guide for scientists and clinicians regarding the global output of ARDS.
Synthesis of Chitosan Stabilized Silver Nanoparticles and Evaluation of the in vitro Antibacterial Activity Against Xanthomonas oryzae pv. oryzae Causing Blight Disease of Rice
Authors: Hien Le Thi , Hue Nguyen Thi Phuong , Duc Le Trong , Huyen Vu Thi , Van Le Thi , Giang Hoang Thi , Ha Chu Duc , Ha Nguyen Thanh , Phuong Nguyen Duy , Ham Le Huy
Published: August 2021

Bacterial blight is one of the most devastating rice diseases that cause huge economic loss worldwide. The cause of rice blight is Gram negative bacteria Xanthomonas oryzae pv. oryzae (X. oryzae pv. Oryzae). Since both silver nanoparticles and chitosan have antibacterial, antifungal and growth-stimulating effect, this work has focused on synthesizing chitosan stabilized silver nanoparticles (AgCSs) with small sizes and in vitro evaluating antibacterial activity against X. oryzae pv. oryzae bacteria. AgCSs were chemically synthesized by reducing silver nitrate by borohydride sodium in the presence of chitosan with optimization of the concentration of the reactants. AgCSs were characterized by UV/vis absorption spectra, field emission scanning electronic microscopy (FESEM), ImageJ software, zeta potential measurement, Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction. AgCSs have spherical configuration and narrow size distributions with different average sizes from 15 nm to 25 nm depending on the initial concentration of silver nitrate. All AgCSs colloidal systems were stable and exhibited no tendency for coagulation more than 5 months. It was the first time that chitosan-stabilized silver nanoparticles were assessed the in vitro antibacterial activity against bacterial blight VXO_281 strain. The disc diffusion method demonstrated that the smallest size silver nanoparticles (AgCS1) showed high antibacterial effect against the X. oryzae pv. oryzae VXO_281 strain with a concentration of more than 5 µg/mL and the inhibition zone was dose-dependent. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgCS1 against X. oryzae pv. oryzae VXO_281 were 2.5 µg/mL and 20 µg/mL, respectively.
APPLICATION FRAUD PENTAGON FOR DETECTING SYMPTOMS OF SHORTFUL FINANCIAL STATEMENTS
Authors: Sudaryono Driya
Published: August 2021

The purpose of this study is to determine the effect of fraud pentagon toward fraudulent financial reporting sympton using modified Jones model to the mining companies. The method of sampling used purposive sampling method. The sample consists of 30 companies was listed on the Indonesia Stock Exchange in 2013-2016. The result of this research concluded that pressure which proxied by financial target and financial stability has a positive and significant effect on fraudulent financial reporting. Opportunity has a negative and significant effect on fraudulent financial reporting. Rationalization, capability, and arrogance has not significant effect on fraudulent financial reporting.
ANALYSIS OF FACTORS AFFECTING COMPANY USING DERIVATIVES
Authors: Sriwati Sriwati
Published: August 2021

This study aims to determine the factors that influence companies in using derivatives. In this study, the factors studied were the cost of debt, foreign sales, risk management, and corporate governance on the company's decision to use derivatives. The analytical method used in this research is logistic regression analysis using the Statistical Product and Services Solutions software. A total of 60 samples were used in this study, which were 20 companies included in the Corporate Governance Perception Index survey from 2016 to 2018. The Corporate Governance Perception Index survey is a survey conducted by the Indonesian Institute for Corporate Governance. The results of this study indicate that the cost of debt variable has a significant effect on the decision to use derivatives by the company. The corporate governance variable also has a significant effect on the decision to use derivatives by the company. The foreign sales variable in this study does not have a significant effect on the decision to use derivatives by companies. The risk management variable does not have a significant effect on the decision to use derivatives by the company. In this study, there are also control variables, namely firm size and return on assets. In this study, the firm size variable does not have a significant effect on the decision to use derivatives by the company. Meanwhile, the return on assets variable has a significant effect on the decision to use derivatives by the company.
ORGANIZATION CULTURE MODERATES THE EFFECT OF MANAGEMENT ACCOUNTING SYSTEM, SUSTAINABLE LEADERSHIP AND ENVIRONMENTAL STRATEGY ON BUSINESS PERFORMANCE
Authors: Fitria Giawan Nur
Published: August 2021

The purpose of this study was to determine whether there is an influence of management accounting system, sustainable leadership and environmental strategy on business performance with organizational culture as a moderating factor. The population in this study are 70 managers of manufacturing company in DKI Jakarta. Sampling technique using a convenience sampling method. Based on research result shows that the management accounting system does not affect business performance; sustainable leadership has a positive effect on business performance; the environmental strategy has a positive effect on business performance. Organization culture does not moderate influence of MAS, sustainable leadership and environmental strategy with business performance.  The results showed that the management accounting system had no significant effect on business performance. This can be a special concern for company management in developing a management accounting information system. The availability of a management accounting information system can maximally assist company management in planning, monitoring and making decisions for business performance is better.
Axiological contradictions of the modern Russian Society and their impact upon professional culture of the future lawyer
Authors: Shtukarev Nikita Andreevich , Strelets Yurii Shlemovich
Published: August 2021

Modern Russian society is currently on the verge of shifting from the traditional (pre-modern) and new (modern) value system, and is characterized by intermediateness and transitivity. In this context, the identity becomes unstable, marginal, without a solid foundation of values. This actualizes the problem of determination of axiological contradictions of the modern Russian society and the degree of their impact upon the cultural institutions formed in accordance with the professional criteria, namely professional culture of the future lawyer. The goal of this article is to establish  axiological contradictions of the modern Russian society and determine the degree of their impact upon professional culture of the future lawyer. Methodological framework is comprised of culturological and axiological approaches. Analysis is conducted on the key development trends of the modern Russian society, which explicates the value contradictions of the Russian society at the present stage. The author provides the original definition of professional culture of the lawyer, reveals the conceptual components of professional culture, as well as the depth and degree of impact of the existing axiological contradictions upon the value core of professional culture of the future lawyer. It is noted that the revealed axiological contradictions of the modern Russian society aggravate the ethical issues of professional culture of the future lawyer. In this regard, the author offers the measures of social support for the future lawyers aimed at minimization of ethical contradictions in professional activity.
Overcoming the phenomenon of “closed doors” in career building within the framework of natural selection
Authors: Kolobaev Sergey Andreevich , Katanskij Sergey Anatol'evich
Published: August 2021

The economy and society currently pose a question of career building of in the significant social groups. Job market is characterized by the emergence of new professions along with a range of new competencies developed at the intersection of various disciplines. Educational institutions do not always prepare their students for real life, and therefore, a graduate or a person with work experience challenge to find employment. In light of the non-transparency and non-uniformity of the job market, as well as devaluation of the continuity of knowledge and experience from the university to the employer, quire ambiguous criteria are imposed upon the potential employee. As a result, large and complex projects can be completed with irrelevant specialists, and persons with work experience and a desire to continue their career building may be left out. Based on the socio-psychological analysis, the author proposes the term of the “closed door phenomenon”, which literally means subjective and objective obstacles in entering a significant social group and striking roots therein. The article offers a definition of the “closed door phenomenon” as a set of behavioral patterns of a person and responses of the reference social groups. The article explores the origin, phenomenology, and key aspects of career building problems, which are referred to as “closed door phenomenon”.  Classification of the proposed solutions is carried out. The author describes the socio-psychological mechanisms of interpretation and correction of unfavorable psychological and professional phenomena in career building within the framework of natural selection.
Female images in the movies of the 2010s about the World War I
Authors: Tribunskikh Natal'ya Ivanovna , Chuprasova Daria
Published: August 2021

The subject of this research is the yet poorly studied topic of representation of the female images in military media sources, namely movies and TV series of the 2010s. The choice of sources is substantiated by the new approaches towards delivery of information, new characters and patterns that correspond to the modern media trends; as well as by a wide range of projects timed to the centenary of the World War I. The key tasks of this article lie in determination of the role of women and characteristics of female images in a number of movies and TV shows of the 2010s about the World War I. The author carries out a comparative analysis of reflection of the Western and Russian cinematography associated with the representations on the gender hierarchy that is seen through interaction between men and women in the material under review. The article reveals the main patterns that are most commonly used for describing the role of women in war. The conclusion is made that a certain variety of female images that have recently appeared in cinematography indicates the interest of historians and researchers dealing with memory, gender, media and visual culture. The comparative analysis of sources demonstrated that the representation of female images in movies of the 2010s about the World War I reflects a certain difference in the officially broadcasted sociocultural and ideological perception of women and their role characteristic to modern Russian and Western society. The Russian movies are oriented towards expressing the official state concept of traditional values and women's affiliation to family and the country; while Western movies create the images typical for their cultural reality, which do not neglect the role of wives and mothers, however allow the heroines to transcend family interests.
Assessment of the causes of the February Revolution in the modern party narrative
Authors: Timshina Ekaterina Leonidovna
Published: August 2021

The February Revolution is one of the key events in the Russian history. Namely this event put the end to the century-long history of the Russian autocracy, and prompted an attempt of a new state structure. A century later, the attitude towards these events determines the ideological basis of multiple Russian parties existing in modern time. Within the framework of establishment of their historical policy, they proposed the original approaches towards the causes of the February Revolution. The author analyzes the perspective of modern parties on the causes of the fall of the monarchy and the advent of revolutionary disturbances. The main sources employ the official documents of the most popular parties (participants of the 2016 federal elections), speeches and publications of their leaders. The conclusion is made on the absence of uniform approach of the parties towards the causes of the revolutionary events of 1917. The author distinguishes the two groups: those who see the causes of the revolution in aggravation of socioeconomic problems; and those who perceive the revolution as coincidence that disrupted the course of history due to certain mistakes made by the government. Unlike the majority of professional historians, multiple political authors assume that the revolution was a result of conspiracy, comparing it to the “orange revolutions” of recent years. The parties also drew parallels between modernity and pre-revolutionary times. The author indicates the need for overcoming (or preventing) the gap between the government and society. as well as reducing the social stratification.
The last parade uniforms of the Emperor Nicholas II: prior to World War I (unknown document from the State Archive of the Russian Federation)
Authors: Shapiro Bella
Published: August 2021

This article introduced into the scientific discourse a previously unknown document from the personal fund of the Emperor Nicholas II stored in the State Archive of the Russian Federation. The document, dedicated to manufacturing of the imperial uniform, is interpreted via examining the sources of personal origin — diaries and memoirs of the last Russian emperor and his immediate circle, authentic uniforms of the Emperor Nicholas II from Moscow and St. Petersburg museums, as well as photographic documents from the Central State Archive of Cinema, Photography, and Audio Documents of St. Petersburg. Methodological framework is based on the chronologically problematic method. In the focus of research is the dynamics of prewar events that cover June – August 1914. Emphasis is also placed on the military representative events of foreign policy nature: parades held during the arrival of the King of Saxony Frederick Augustus III to Russia, as well as the visit of French President Raymond Poincaré. The acquired materials can be valuable for in-depth research on the military history of Russia, history of Russian culture as a whole, history of its tangible culture and costume history. Another area of possible practical implementation is the research work on studying the Russian military uniform in the museum, aimed at fulfillment of its historical-cultural potential and historical uniqueness.
Greek demons who murdered children
Authors: Makeeva Vladislava Igorevna
Published: August 2021

This article describes the Ancient Greek mythological characters who were attributed with murdering children: Lamia (Λάμια), Mormo (μορμώ) and Gello (γελλώ).The ssuperstitions associated with these demons remain in Greece to this day, although their images have undergone certain transformation. The object of this research is the mythological representations of the Ancient Greeks, while the subject is demons who murdered children. The goal of this article is to determine the role of children's horror stories in life of the Ancient Greek society. The author reviews the facts testifying to the existence of characters as Lamia, Mormo, Gello and Empusa in the Greek and Roman texts, as well gives characteristics to their images based on the comparative analysis. The conducted analysis reveals the common traits of the demons who murdered children: frightening appearance, combination of human and animal traits, ability to transform, identification with Hecate, as well as the story of the failed motherhood underlying the history of emergence of the demon. The key functions of these mythological characters consisted in explanation of the sudden infant and maternal mortality typical to the ancient times, as well as teaching children and adults a lesson. The first could be frightened with such stories, and the latter had to learn from the tale that demonstrates the harm of reckless following the temptations or refusal of fulfilling the prescribed social roles, socially acceptable behavior.
Monitoring and troubleshooting in distributed high-load systems
Authors: Rudometkin Vasilii Андреевич
Published: August 2021

The subject of the research is the problem of monitoring and troubleshooting in distributed high-load systems. The most common mistakes in design and development, methods of their forecasting and solutions are described. In this article, the author describes the most popular tools that are currently used in the development of high-load systems and the main mistakes when working with them from a developer's point of view.This article describes a set of tools, the implementation of which can significantly reduce the time spent searching for vulnerabilities, describes the difficulties in choosing a set of metrics technologies - ELK / EFK, describes their advantages and disadvantages. The analogs of the tools used are analyzed in detail. The main conclusions in the work are:- the need to develop the infrastructure for monitoring the system from the beginning of the project development, due to which it is possible to correct the high complexity of the project at the stage of its development.- it is necessary to use the most popular tools for which there is a large amount of information in open sources, for example, on the Internet. This approach will reduce the time spent on fixing errors that can be caused by a specific set of tools.- the company needs not to save on highly qualified personnel, which in the future will save a lot of time on fixing problems, reduce the time for developing new functionality and allow spending a minimum of time to support and test the already developed functionality.- when analyzing problems, it is worth paying attention to public resources in which other companies, most likely, have already solved similar problems. For example, the Facebook company has been dealing with the monitoring problem for a long time and has developed a large number of tools to solve this problem. They also collect a large number of system records for analyzing the behavior of the system under any circumstances.
Simulation of the absorption of gaseous SO2 by fog droplets using a refined interpolation-sectional droplet model
Authors: Pekunov Vladimir Viktorovich
Published: August 2021

This article examines the problem of numerical simulation of interaction between the gaseous sulfur dioxide emitted by road transport and fog in the conditions of high humidity. For this purpose, the author applies a multi-factor two-phase mathematical model, which takes into account the dynamics of turbulent main phase, dynamics and kinetics of the multi-sectional droplet phase, presence of thermal inconsistencies formed as a result of direct and diffused solar radiation in various ranges, diffusion of sulfur dioxide, and its absorption by the fog droplets. The article carries out a numerical calculation of the corresponding task within the modeling system of environmental processes AirEcology-P, which allows generating the optimal calculation code for a particular mathematical model. The proposed complex mathematical model that descries interaction between the emitted sulfur dioxide gas and the fog droplets is new; it specifies the calculation of the kinetics of droplet phase based on consideration of the additional factor of droplet fusion characteristic to fog. The submodel of the droplet phase was tested in the numerical simulation (the results were compared with the data of direct Lagrangian modeling of the composite of 1,000 droplets), indicating decent accuracy results. The article obtains the results of numerical simulation of interaction between the emitted SO2 and the droplets. The author demonstrates the self-cleaning ability of the atmosphere, the degree of which correlates with the initial concentration of the smallest droplets and the height from the surface.
Relational database problems
Authors: Alekseev Konstantin
Published: August 2021

The relevance of this article lies in the fact that today's databases are the basis of numerous information systems. The information accumulated in them is extremely valuable material, and today database processing methods are widely spread in terms of extracting additional methods, knowledge from them, which are interconnected with generalization and various additional methods of information processing.The object of research in this work is relational databases and DBMS, the subject of research is the features of their use in applied programming.In accordance with the set goal, it is necessary to solve the following tasks:1) to consider the concept and essence of a relational database;2) to analyze the problematic aspects of relational databases in modern conditions. Relational databases are among the most widespread due to their simplicity and clarity at the creation stage and at the user level. It should also be noted that the main advantage of RDB is its compatibility with the main query language SQL, which is intuitive for users.Nevertheless, with all the variety of approaches, there are still some canons, violation of which greatly affects both the design of the database and its operation. For example, the problem of database normalization is very relevant. Neglecting normalization makes the database structure confusing and the database itself unreliable.Promising directions include the development of queries to a relational database using heuristic methods, as well as the method of accumulating previously optimized queries with subsequent verification of the derivability of the current query from the accumulated ones.Finally, a very slow decline in relational databases is probably happening. While they are still the primary storage medium, especially in large enterprise projects, they are gradually being replaced by non-relational solutions that will become the majority over time.
Design of the database structure for software optimization of operation of the stochastic multiphase systems
Authors: Selishchev Ivan Alekseevich , Oleinikova Svetlana Aleksandrovna
Published: August 2021

The object of this research is the service systems that receive a stream of requests on their input, which represents a range of mutually dependent operations of the “finish” – “start” type. The time of conducting separate operations is a random variable, and the delivery itself requires the use of one or several types of resources. It is suggested that there are timeframes for processing the request. The goal of this research is to develop the database structure that would allow storing information on the incoming projects, operations, mutual dependence, used resources and specialists. The design of logical structure of the database was carried out using the methodology “essence – link”, which determines the data values in the context of their correlation with other data. The analysis of specificity of the object of research revealed a range of requirements submitted in the database. Leaning on these requirements along with considering normalization of relations used in the theory of relational databases, the author designed the universal structure from the perspective of its application, support of the analysis of the scheduling process, and the entirety of peculiarities of the object of research. Such database structure can be used in different fields that allow decomposition of the project into multiple separate interdependent tasks, not requiring major modifications. The article provides the examples of using the database for information systems in construction sector, as well as for the development of IT projects.
The calculation of thermodynamic functions for simulation model of the column string-emulsion reactor
Authors: Sechenov Pavel , Rybenko Inna , Tsymbal Valentin
Published: August 2021

The simulation model of the column string-emulsion reactor previously suggested that the temperature does not change on the height of reactor and over time is consistent. The assessment of temperature changes in the reactor requires the knowledge on the amount of heat necessary to heat up the particles, absorbed or emitted in the course of chemical reactions, as well as the speed of heat transmission in space. The possibility of calculating these parameters for each floating particle in online regime is limited by the operating speed of the computer system. For accelerating the calculations, the author creates the database of these parameters for all substances involved in the reactions. In these circumstances, enthalpies and entropies were expressed in through the specific thermal capacity calculated based on the fifth degree polynomial. The coefficient values of the polynomial and phase transitions were taken from the reference books. The article provides an algorithm in form of the logic diagram for calculating the specific enthalpy of the particle. Based on the developed algorithm, the author creates the software that allows calculating thermodynamic functions. The interaction between the classes are demonstrated in the UML class diagram. The research presents the calculations of specific enthalpy and entropy for substances in the interval of temperatures of 298-1850 K. Variations of the values of enthalpy and entropy at the temperature of 1700 K compared to the reference values do not exceed 1.2 %.
Trombose venosa cerebral: a relevância da neuroimagem
Authors: Castro Luana Fernandes da Silva Oliveira , Pitanga Lorena Sipauba , Costa Maria Júlia Ribeiro da , Santos Geovanna Godinho , Lôbo Gabriela Almeida , Fernandes Fernanda Rodrigues Mangabeira , Caselato Maria Letícia Lopes Mol , Geronasso Vitoria Fossari , Trajano João Gualda Garrido , Petter Jobe
Published: August 2021

Objetivo: Analisar a importância da neuroimagem no diagnóstico da trombose venosa cerebral. Revisão bibliográfica: A Trombose Venosa Cerebral (TVC) possui uma evolução inespecífica, a grande maioria dos pacientes apresenta cefaleia como manifestação inicial, podendo ou não estar associado a sintomas focais. Diante dos inúmeros sinais e sintomas que podem estar presentes, o diagnóstico clínico se torna improvável, pois além da sintomatologia inespecífica, a TVC pode mimetizar inúmeras doenças neurológicas. Assim, a Tomografia Computadorizada (TC) e a Ressonância Magnética (RM), associadas ou não a venografia, assumem um protagonismo indubitável no diagnóstico da trombose das veias e seios cerebrais. Em geral, o primeiro exame de imagem solicitado é a TC, contudo, para uma avaliação mais minuciosai e precisa do sistema cerebral a RM é preferível. Apesar de ser uma condição grave, o diagnóstico precoce e a intervenção terapêutica definem um bom prognóstico ao paciente, sendo crucial, portanto, a precisão e a velocidade na realização do diagnóstico, prevenindo assim, complicações e desfechos fatais. Considerações finais: A análise dos artigos estudados, evidenciaram a relevância dos métodos de neuroimagem como medidas indispensáveis para o diagnóstico definitivo de trombose venosa cerebral.
O papel do agente comunitário de saúde: percepção de gestores municipais de saúde
Authors: Caçador Beatriz Santana , Caneschi Juliana Aparecida , Silva Laylla Veridiana Castória , Souza Ramon Augusto Ferreira de , Amaro Marilane de Oliveira Fani , Rezende Lilian Cristina , Caram Carolina da Silva , Brito Maria José Menezes
Published: August 2021

Objetivo: Conhecer a percepção de gestores municipais de saúde sobre o papel do agente comunitário de saúde. Métodos: Estudo qualitativo, realizado em uma microrregião de saúde no interior de Minas Gerais. Participaram 8 secretários de saúde e 8 coordenadores da atenção primária à saúde. Coleta de dados ocorreu por meio de entrevista aberta orientada por roteiro semiestruturado, no período de abril a junho de 2018. Realizou-se Análise de Conteúdo de Bardin. Os aspectos éticos da pesquisa com seres humanos foram respeitados. Resultados: Os gestores reconhecem, de modo coerente com as atribuições previstas, o papel do agente comunitário de saúde, sobretudo, no que tange a constitução do elo entre a equipe de saúde e a comunidade, as facilidades de residir na comunidade e a dificuldade do reconhecimento de seu papel pela população. Além disso, apresentam-se conscientes sobre os desafios de deslocamento inscritos no cotidiano do agente comunitário de saúde, a falta de capacitação e de materiais de trabalho. Conclusão: Constata-se através do estudo, que os gestores reconhecem de modo coerente as atribuições previstas ao agente comunitário de saúde e afirmam reconhecer sua importância. Porém, essa valorização parece não encontrar eco nas condições de trabalho desse profissional viabilizadas pelos gestores.
Interactive teaching in medical education: Experiences and barriers
Authors: Verma Anjana , Patyal Ashish , Meena Jitendra Kumar , Mathur Medha , Mathur Navgeet
Published: August 2021

An interactive teaching method is a form of learning and communicative activity, which focuses on students’ needs and allows them to actively participate in the learning process. With the introduction of competency based medical education (CBME), new teaching methods have been introduced to ensure the attainment of competencies by medical graduates. Research shows that interactive activity in class is an effective teaching learning method. There are many studies which have reported that students prefer interactive lectures based on active learning principles. Despite this, it has been found that many students do not engage with active learning exercise, which is probably due to the reason that among students, there is an already established culture of teaching and learning. The interactive lectures need to be designed after exploring student expectations, feedback, and experiences. Faculty members too have their own skepticism about the use of innovative methods in their teaching. These challenges need to be addressed for successful implementation of CBME based curriculum in medical education. With this review, we present the experiences about the use of interactive teaching methods in the field of medical education and also point out various barriers and challenges on the path of its execution.
Esthetic dermatology set up in a hill station in North East India
Authors: Sethi Jagjeet Kaur
Published: August 2021

Esthetic dermatology till recently was considered a domain of only the metro cities and for those of the celluloid world. Setting up an esthetic dermatology practice is a difficult task in Northeast India. Our set up is located in Shillong, capital of Meghalaya, also known as “Scotland of the East,” just adjacent to Malki Forest in neighborhood, next to Lady Hydari Park, Barik, Shillong. Since patients had to travel long distances, we tried to provide all facilities under one roof which included an in-house cafeteria, laboratory, pharmacy, counseling, minor OT and laser rooms, recovery room, and reception totaling up to approximately 12 rooms. We are two dermatologists handling an average of fifty patients daily along with procedures. Over the years, we have found the following lasers and lights to be helpful to our patients QS pigment laser, diode hair removal laser, excimer lamp, CO2 laser, intense pulse light, iclearxl and NBUVB also procedures as microdermabrasion, microneedling, microblading, micro needling radiofrequency, monopolar radiofrequency, regenera active, platelet rich plasma, chemical peels, cryotherapy, injectables as neurotoxins, dermal fillers, skin boosters, lipolytics and thread lift in no particular order. Esthetic dermatology makes up about 35% of my practice.
Risk assessment of acquiring SARS-CoV-2 infection among employees of a tertiary cancer care center
Authors: Sawakare Sandeep S. , Tandon Sandeep P. , Pramesh C. S. , Gupta Sudeep , Sengar Manju , Laskar Sarbani Gosh , Nair Sindhu S. , Mishra Gauravi A. , Goel Nishu S. , Patkar Shradha , Badwe Rajendra A.
Published: August 2021

Objectives:

Continuation of health-care facilities for non-COVID illness during the SARS-CoV-2 pandemic is mired with apprehension of infection to health care workers (HCWs). The lack of facilities can result in dire outcomes for patients of NCDs such as cancer. The Objective of this paper is to assess the risk of running a healthcare facility during the pandemic.

Material and Methods:

A retrospective analysis was carried out at a tertiary cancer hospital to understand the quantum of risk to HCWs while providing care to patients of cancer and to SARS-CoV-2 patients, within the same set-up with optimal segregation. Data were collected for 6 weeks during which attendance, exposure, and infection status of doctors and nurses were recorded along with comorbidities.

Results:

Of 1041 doctors and nurses who attended duties during the study period, 299 worked in dedicated COVID care areas while 742 worked in routine cancer care areas. The proportion of HCWs that developed symptoms or were tested positive for COVID-19 was 3.7% and 3.9%, respectively, with no statistically significant difference between the two. The proportion for the same was found to be 1.2% among the 645 staffs who were on leave. No correlation could be established between pre-existing comorbidities and risk of acquiring infection.

Conclusion:

Providing COVID care and routine specialty care within the same hospital premises do not put the HCWs at a drastically increased risk of acquiring infection subject to clear demarcation of work areas, screening at gates by trained personnel, regulation of number of hospital visitors, and optimal use of PPEs.
Assessment of polymorphism using RAPD in the generalized hemiparasitic plant Helicanthes elasticus (Desv.)Danser collected from six different hosts
Authors: Ajithkumar T.G. , Lizzy Mathew , Sunil Kumar K.N.
Published: August 2021

RAPD analysis was carried out to determine genetic diversity that occurred among the selected accessions of H.elasticus obtained from six different hosts. All together 10 random primers were used for the RAPD assay, of which primer S11 produced 12 amplified bands in which 10 are polymorphic. Primer S9 produced the least number of amplified fragments. 10 primers together resulted in 88 amplified fragments, of which 26 are found to be polymorphic. Considerable polymorphism was shown by 3 primers that can be represented in a descending order S11>S79>S10. Accessions of H.elasticus obtained from Anacardium occidentale and Citrus maxima produced more polymorphic bands with S11. The overall polymorphism obtained in the selected samples of this hemiparasite was 29.54 indicating that genetic similarity was more among these samples rather than genetic diversity.
Computationally predicted virus responsive miRNAs in banana (Musa AAB)
Authors: Mathew K.S.A. , Athira Subramanian , Soni K.B. , Swapna Alex , Sreekumar J. , Kiran A.G.
Published: August 2021

The bioinformatics tool NovoMIR was used to predict miRNAs in Musa acuminata genome. NovoMIR predicted 85 pre-miRNAs from the 11 chromosomes of Musa acuminata DH Pahang and BLAST analysis of the predicted pre-miRNAs against annotated miRNAs of miRBase identified 52 mature miRNAs belonging to 38 different families. psRNATarget server identified 124 protein-coding sequences as potential targets for 40 mature miRNAs. Based on the role of the target genes in biological processes related to biotic stress, five miRNAs were selected for analyzing their response to Banana bract mosaic virus (BBrMV) infection. Three-month-old in vitro raised banana plants of var. Nendran (Musa AAB) infected with BBrMV showed the presence of all the five selected miRNAs in both healthy and BBrMV infected plants. Expression analysis using RT-qPCR showed changes in the expression of miR-3900-5p, miR-2172-5p, miR-6928-5p and miR-971-5p and their targets during BBrMV infection.
Identification of bioactive compounds and potential inhibitors for Breast cancer from Musa sapientum peel – An in vitro and in silico approach
Authors: Sangavi P. , Rajapriya R. , Sannathul Firthous , Langeswaran K. , Gowtham Kumar S.
Published: August 2021

In this study, the aqueous and ethanol extracts of Musa sapientum peel and pulp were investigated for phytochemical screening and antioxidant activity. Antimicrobial activity and Minimal Inhibitory Concentration (MIC) were analyzed against three different microbial pathogens. From the reported GCMS analysis, the selected compounds were subjected to anti-cancer activity against breast cancer using in silico study. The highest antioxidant activity, presence of secondary metabolites and microbial activity were observed in a significant range. MIC examination revealed that the three different microbial pathogens were sensitive for the peel extract. . In silico study, out of 7 selected compounds, 4 compounds exhibit the highest docking score, binding free energy and acceptable pharmaceutical properties. Molecular dynamics simulation was performed for the top two compounds and the resulting analysis explained the protein-ligand stability and the results concluded that the lead compounds possess the highest stability. From this study, it was concluded that the selective bioactive compounds from Musa sapientum peel exhibited significant antioxidant and antimicrobial activity through in vitro analysis and also the bioactive compounds possessed anti-cancer property which was revealed by in silico investigation.
Characterization of the hypothetical proteins of Human Papillomavirus DNA consensus sequence
Authors: Jamkhedkar Suruchi
Published: August 2021

The diagnosis of HPV infection is generally carried out using immunological and molecular techniques based on high risk to probable high-risk HPV strains. The aim of this work is to generate a global representation of HPV strains for diagnosis and drug development. In this work, all the complete genomic DNA sequences of registered Human Papillomavirus (HPV) strains available in NCBI GenBank were used to obtain a consensus sequence of HPV using the Genetic Algorithm. The consensus DNA sequence was translated using the ExPASy software tool. In all, six longest amino acids frames were selected from the six translated frames. The amino acid sequence identity was carried out using the BLAST tool. The six amino acid sequences were identified as E1, E2, E6, E7, L1 and L2. The homology modeling method (Modeller Software Tool) was used to determine the secondary structure of these six identified primary amino acid sequence. The percentage of similarity ranged from 24% in L2 to 100% in E7 and L1. The functions of these structural domains were also determined from PDB databank, InterProScan and CATH. Hence the consensus sequence built using a genetic algorithm is representative of the HPV genome which can be used for diagnostics and drug development purposes.
A short review of CD73 Role in Cancer
Authors: Farhad Hariri Akbari , Lucija Slemc , Mahdi Alizadeh , Mahnaz Hatami Fard , Peymaneh Shafaei
Published: August 2021

The purinergic signaling pathway has been introduced as the main way in the progression of cancer and is regulated by producing a series of nucleotides. CD73 is a surface protein encoded by the NT5E gene and plays a crucial role in cell signaling. CD73 has both enzymatic and non-enzymatic functions, independent of its enzymatic activity in cells; it has been detected to be over-expressed and plays an important role in many types of cancer. However, the non-enzymatic function of CD73 has not been well studied yet. Findings from recent research show that CD73 activities are exploited as ectoenzyme to produce extracellular adenosine; in other words, there is a tumor-induced immunosuppressive mechanism for CD73. It can increase tumor proliferation and development by restricting antitumor T immunity through adenosine receptor signaling. Several factors and mechanisms have been used to control CD73 expression. Studies in various models have shown that CD73 plays a key role in the growth of tumors; it has also become an attractive therapeutic goal for scientists in many studies related to cancer. They include identifying different cancer subsets, the anticipation of drug response in patients, precipitation of purine escape pathway activity etc. Collective studies have proved that CD73 is a substantial molecule that formulates proliferation, colonialism and invasion in vitro, angiogenesis and immune escape in vivo in cancer and tumor cells. The data has shown that the potential of CD73 distinguished it as a recognizable biological marker in the next generation of treatment and research studies on cancer.
A concise critique on Breast Cancer: A historical and scientific perspective
Authors: Manobharathi V. , Kalaiyarasi D. , Mirunalini S.
Published: August 2021

Breast cancer, the most pervasive cancer afflicting 2.1 million women worldwide, contributes to the highest number of cancer deaths in women. It can affect both genders, but it is more prevalent in women than in men. It seems to be the major unbearable global cancer burden. As a result, it creates a great impact on society. The exact etiology is still mysterious, but its associated risk factors were evidently identified. Although there are several sophisticated treatments available, continuing changes in the breast cancer prognosis culminated in more than 60 % of mortalities from this metastatic disease. Therefore, in an attempt to offer a clear picture of this enigmatic condition, this review outlines a concise summary of the breast cancer history, epidemiology, types, available treatments, genomics role, signaling pathways as well as its alternative splice variants.
MAPK: A promising signaling pathway in targeted therapy for the treatment of NSCLC
Authors: Thirunavukkarasu Muthu Kumar , Karuppasamy Ramanathan
Published: August 2021

Aberrant stimulation of MAPK (Mitogen-activated protein kinase) signaling pathway triggers the dysregulated cell growth and resistance to apoptosis in a wide variety of tumors especially in NSCLC (Nonsmall cell lung cancer). Most of the research is on treating lung cancer by targeting the MAPK pathway receptors. Nevertheless, it is essential to consider interconnections and mode of action to resolve the drug resistance ad feedback loops during the treatment with checkpoint inhibitors. Here we describe the overall mechanism of MAPK pathway, oncogenic mutations and precise information regarding the drug compounds for each receptor in this pathway. Further, in-depth insights into this review could be beneficial for the empathetic discovery of inhibitors for NSCLC against this pathway.
Probiotics and its Applications: A Systematic Review
Authors: Cyriac Rajath , Datta Riya
Published: August 2021

The digestive system of human beings contains a large group of microbes which help in controlling the host’s internal environment and thereby assist in maintaining the health of the host. These microorganisms exist in a mutual relationship with the human host which has led to extensive research in this particular field. Most of these microorganisms have become resistant to day-today drugs and antibiotics. These organisms control various functions like defense, eupepsia, catabolism, anabolism and also help in brain-gut responses. Probiotics assist in improving gut bacteria and are found to be effective in controlling various diseases. Prescribing probiotics to children with malnutrition in underdeveloped countries can reduce the death of many children. This review outlines the importance of probiotics in human health and in the treatment of several metabolic disorders.
IGUALDADE DE GÊNERO NA CONSTITUIÇÃO FEDERAL DE 1988: O MOVIMENTO FEMINISTA BRASILEIRO E A CONSQUISTA DO PRINCÍPIO DA IGUALDADE
Authors: Terra Bibiana , Tito Bianca
Published: August 2021

Considerando-se a trajetória de luta das mulheres brasileiras, muitas vezes por intermédio do movimento feminista, essa pesquisa tem como objetivo analisar a conquista do Princípio da Igualdade na Constituição Federal de 1988. O seu inciso I do artigo 5º prevê que homens e mulheres são iguais em direitos e obrigações, sendo este um marco da igualdade de gênero no Brasil. Para a sua realização foi adotada a metodologia da pesquisa bibliográfica e traz como resultados que a Constituição Federal de 1988 foi explícita ao declarar a igualdade entre homens e mulheres, sendo que essa previsão resulta de demandas feministas.
(IN) EXISTÊNCIA DE ESTEREÓTIPOS DE GÊNERO NA JURISPRUDÊNCIA PORTUGUESA
Authors: Sousa Janaina Silva
Published: August 2021

Para compreender se a jurisprudência portuguesa atua no sentido de manutenção/construção de hierarquias de gênero fez-se análise de decisões judiciais sobre crime de violação, cujo pólo passivo seja mulheres adultas; crime ao qual geralmente o estereótipo de gênero é tese de defesa. Foram escolhidos os Tribunais de Relação de Lisboa e Porto com processos no período de 2016 a 2019, o foco nas vítimas mulheres adultas serve para demarcar o objeto, uma vez que a abordagem muda conforme o sujeito. O que se percebeu é que não há a criação ou reprodução de estereótipos no corpo dos processos judiciais analisados.
TRABALHO DOMÉSTICO NÃO REMUNERADO E A CRISE DO CUIDADO: UMA VISÃO FEMINISTA SOBRE OS EFEITOS DA COVID-19
Authors: Esteves Lorena Meirelles , Maia Lia Vidigal
Published: August 2021

Mesmo após inúmeras conquistas dos movimentos feministas, persiste a dicotomia histórico-social que exclui as mulheres do âmbito público e impõe a responsabilidade do cuidado doméstico e emocional, culminando na sobrecarga física e psíquica. Em verdade, a exploração da sua força de trabalho é instrumento de subalternização em razão do gênero, agravado em razão da pandemia da COVID-19, conforme demostrando pelo relatório do Fórum Mundial de Economia, realidade que, de acordo  com os ensinamentos Hanna Arendt, Silvia Federici, Angela Davis e outras, percebe-se a urgente necessidade de mudança, através de políticas públicas eficazes, aptas a garantir a igualdade de gênero.