bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in left atrial function after percutaneous closure of patent foramen ovale
Authors: Qiu Lin , Li Min , Wang Zhi , Fan Fangfang , Yi Tieci , Weng Haoyu , Yang Ying , Ma Wei
Published: May 2023

Purpose This study aimed to investigate left atrial (LA) function following patent foramen ovale (PFO) closure.Methods Patients with PFO who underwent transcatheter closure between 2015 and 2022 and had complete echocardiography examination data available at baseline and at least twice during 1-year of follow-up were enrolled. LA function was evaluated by measuring LA reservoir strain (LASr), conduit strain (LAScd), and contractile strain (LASct) through speckle-tracking echocardiography. Differences in LA strain between baseline and at the different follow-up times were compared using repeated-measures analysis. The association between risk factors and LA strain was evaluated in a univariable and multivariable linear regression model.Results Forty-five patients were included. After 3 months, we observed a decrease in LASr (from 40.98–33.09%, P < 0.05), which recovered to 37.30% at 6 months (P = 0.06). LAScd decreased significantly from baseline after the procedure (P < 0.05) but had recovered by 3 months (19.96% vs 19.04%, P = 0.06). LASct decreased significantly between baseline and 6 months (from 17.92–14.01%, P < 0.05). All changes resolved by 1 year. Multivariable models showed that LA strain at baseline was the most important factor affecting LA function. LA diameter was significantly associated with sustained changes in LAScd (β = 7.19, P = 0.038). Age was a risk factor for difficult recovery of LASct after PFO at 3 months.Conclusions Implantation of a PFO occluder has a transient adverse impact on LA function in the area adjacent to the device but resolves within 1 year.
Iterative decomposition of visuomotor, device and cognitive variance in large scale online cognitive test data
Authors: Giunchiglia Valentina , Gruia Dragos , Lerede Annalaura , Trender William , Hellyer Peter , Hampshire Adam
Published: May 2023

Online cognitive assessment technologies are gaining traction as scalable and cost-effective alternatives to traditional supervised testing. However, variability in peoples’ home devices, and their visual and motor abilities, confound the cognitive specificity of online task performance scores. To address these limitations, we develop IDoCT (Iterative Decomposition of Cognitive Tasks), a novel method for estimating cognitive abilities and trial-difficulty scales from task performance timecourses in a data-driven manner while accounting for device and visuomotor latencies, and speed-accuracy trade-offs. IDoCT can operate with any computerised task that manipulates cognitive difficulty across trials. Using data from 388,757 adults across 12 online cognitive tasks, we show that IDoCT successfully dissociates cognitive abilities from visuomotor response latencies. The resultant cognitive scores exhibit superior psychometric structure and associations with demographic factors while being insensitive to testing device. We propose that IDoCT can enhance the precision of online cognitive assessments for diverse clinical and research applications.
An Investigation of the Usage of Glass Wastes in Cement Mortars Using Full Factorial Design
Authors: ÇANKAL Dilan , KALKAN Şevket Onur , ÖZTÜRK Ali Uğur , GÜNDÜZ Lütfullah
Published: May 2023

Waste management in the world has come to the fore in recent years. Like many materials used as alternative raw materials, glass waste has become an increasingly important situation. It is very important in terms of sustainability that these wastes are used as alternative raw materials in the production of new materials for various industries. Recycling of glass, which is produced and consumed in a wide range, contributes to many different sectors. For this purpose, the use of materials obtained in two different forms, namely powder and fiber produced from waste glass, in cement mortars was investigated. There are three factors, including glass powder (GP) amount with four levels of 0, 45, 90 and 135 g, glass fiber (GF) amount with two levels of 0 and 13.37 g, and curing period (CP) with three levels of 7, 28 and 56 days. Compressive, flexural strengths and abrasion resistance of cement mortar samples were determined. In addition, acceptable regression models were derived by using multiple regression analysis. Analysis of variance (ANOVA) showed that the effects of all three factors on the mechanical properties and, GP and CP factors on abrasion resistance of cement mortars are significant. Improvements in mechanical strength and abrasion resistance were observed in the use of glass fiber and glass powder added cement mortars produced at appropriate rates. The study shows that the use of glass fiber and glass powder separately or together in the production of cement-based materials such as concrete, which is exposed to abrasion, is beneficial. As a result, the properties expected from the produced concrete will be met. The use of glass waste will contribute to the realization of an economical and environmentally friendly concrete production.
Ontology Based Access Control: A Case Study through Ontology Based Data Access
Authors: CAN Özgü , ÜNALIR Murat
Published: May 2023

Ontology Based Data Access (OBDA) is the provision of data access and data integration as a result of the mapping that is established between an ontology and a data source. Thus, storing large amounts of data becomes easier, more powerful queries can be written, and management of complex information systems can be performed quickly and effectively by using Semantic Web technologies. Ontology Based Access Control (OBAC) uses Semantic Web technologies to enable the enforcement of access control mechanism. Therefore, only authorized persons can access data to protect data privacy. In this study, OBDA and OBAC are integrated to improve security while providing data virtualization with a data model-independent access control approach. Therefore, a use case study for the healthcare domain is presented. Hence, a relational database for the hospital domain, a Hospital Ontology for the related hospital database and an access control policy are created. Also, the relevant mappings between the hospital database and the Hospital Ontology are established by using the Ontop framework and finally, various queries are executed by using Ontop SPARQL to evaluate mappings and access rules.
RELEVANCE OF MACHINERY SLAUGHTERING OF ANIMALS IN THE MODERN ERA IN A REVIEW OF ISLAMIC LAW
Authors: Ritonga Raja , Aminah Siti
Published: May 2023

Food and drink are two things that everyone needs. However, for a Muslim, halal food and drinks are always a priority. Therefore, not all food and drinks are halal for consumption, such as the halalness of animals or animals. Islamic teachings teach that the halal and unlawful slaughter of animals is closely related to the method of slaughtering them. This article explains and describes the relevance of slaughtering animals using cutting machines in the modern age. This research uses a qualitative method type of literature study. The data used in this study came from the search results of some books, MUI fatwas, articles, and others related to research. Furthermore, the data were analyzed descriptively using a normative approach. The results of the study explain that the slaughter of animals using a slaughter machine is considered valid if it meets the requirements set out in the MUI fatwa’s.
DA’WAH BI AL-HAL: MOSQUE-BASED RELIGIOUS TOURISM DESTINATION MANAGEMENT AT GREAT MOSQUE OF DEMAK
Authors: Muhajarah Kurnia
Published: May 2023

Islam has left various important historical relics in the form of tombs, mosques, ex-kingdoms, customs and so on, that can be used as tourism potential. One of the tourism activities is in the form of mosque tourist destinations. As a formulation of the problem, what is the development of ODTW mosque management? How is the development of da'wah through mosque-based religious tourism? This writing uses a library research and it is qualitative by descriptive analysis. The results showed that the development of da'wah through mosque-based religious tourism had proceeded as expected. These could be seen, from the aspects of planning, organizing, actuating and controlling. From the aspect of planning, the planning of da'wah in the mosque has been well managed in accordance with management principles. The managers of mosques have well planned in the development of da'wah. Da'wah activities that will be carried out to achieve the objectives to be achieved effectively and efficiently have been realized as management guidelines. Likewise, when paying attention to the organizing system of da'wah developed by mosque managers, it can be said that the organization of da'wah has succeeded in attracting tourists and the growing development of Islamic syi'ar. Viewed from the aspect of organizing of da'wah that this problem has succeeded well. Judging from the aspects of da’wah’s controlling, this has been done by the managers and members of the mosque well and successfully. Even so, there are still some shortcomings, and these shortcomings must receive attention. Therefore, this research is expected to provide a solution to overcome the shortcomings of mosque tourism destinations in the tourism industry era.
Alliance of two pandemics: COVID-19 and diabetes mellitus
Authors: Kovalevskiy Dmitriy V.
Published: May 2023

Objective: to study the features of the course of viral pneumonia in patients with diabetes mellitus. Materials and methods. A random sampling method was used to conduct a retrospective analysis of 300 archival medical records of inpatients with laboratory-instrumentally confirmed COVID-associated pneumonia for the period 2020-2022. Results. As a result of the study, two groups were formed - the main and control. The main group included 150 patients diagnosed with diabetes mellitus; the control group consisted of 150 patients without diabetes mellitus. The average number of bed-days spent by the main group in the hospital was 12.4 days, the control group - 10.5 days (р˂0.001). Significantly more often, the main group of patients is diagnosed with a serious condition at the time of hospitalization, as well as unilateral localization of the pathological process in the lungs. Conclusion. In patients with diabetes mellitus and pneumonia caused by a new coronavirus infection, a dependence of the volume fraction of lung tissue damage on the level of hyperglycemia was revealed. In patients with DM, anticoagulant therapy was carried out longer during inpatient treatment, combinations of several groups of antibacterial drugs were used more often, and the starting dose of glucocorticosteroids was also higher.
Przepowiadanie homilijne w Polsce
Authors: Dyk Stanisław , Sławiński Henryk , Szewczyk Leszek
Published: May 2023

Celem artykułu jest krytyczna analiza treściowych i formalnych aspektów homilii wygłoszonych w ramach Mszy Świętych transmitowanych przez Internet od 9 maja do 13 czerwca 2021 r. Ocenie poddano 28 homilii zawartych w 38 transmisjach, zarejestrowanych w dwudziestu polskich diecezjach. Przeprowadzone analizy pozwoliły na wyciagnięcie wniosków dających obraz przepowiadania homilijnego w Polsce. Głoszone treści mają zazwyczaj charakter pozytywny i są wolne od błędów doktrynalnych. Brakuje im jednak pogłębienia teologicznego i solidnych analiz tekstów biblijnych. Należałoby zatem poprawić ich teologiczną, biblijną i mistagogiczną jakość. Poważnym mankamentem badanych homilii jest także niski stopień aktualizacji antropologicznej oraz braki w warstwie egzystencjalnej i moralnej. Niedociągnięcia dotyczące strony formalnej rodzą konieczność poprawienia kompetencji homilistów w zakresie operowania żywym słowem.
The Fear of the COVID-19 Pandemic and Its Relation to Religion
Authors: Krzos Bartłomiej Marian
Published: May 2023

It is known that the COVID-19 pandemic can be a cause of fear and anxiety. There exists a deep need to seek refuge from anxiety in a reality that would offer a sense of greater certainty. Within this framework, religion can be assessed in three different ways. Its negative assessment is linked with a pragmatic approach to the world. Alongside the negative assessment of religion, there is also a positive one. However, there is still a third possible approach, that of using religion as a response to the difficulties of the pandemic. Religion can function as a factor in rationalizing the time of the pandemic. Religion can also generate two strategies by which a person can respond to difficult situations. These strategies can be referred to as a kenotic one and a palliative one.
Curcumin and its Derivatives Targeting Multiple Signaling Pathways
to Elicit Anticancer Activity: A Comprehensive Perspective
Authors: Fatima Firdous , Chourasiya Nikhil Kumar , Mishra Mitali , Kori Shivam , Pathak Sandhya , Das Ratnesh , Kashaw Varsha , Iyer Arun K. , Kashaw Sushil Kumar
Published: May 2023

The uncontrolled growth and spread of aberrant cells characterize the group of
disorders known as cancer. According to GLOBOCAN 2022 analysis of cancer patients in
either developed countries or developing countries the main concern cancers are breast cancer,
lung cancer, and liver cancer which may rise eventually. Natural substances with dietary
origins have gained interest for their low toxicity, anti-inflammatory, and antioxidant effects.
The evaluation of dietary natural products as chemopreventive and therapeutic agents, the
identification, characterization, and synthesis of their active components, as well as the enhancement
of their delivery and bioavailability, have all received significant attention. Thus,
the treatment strategy for concerning cancers must be significantly evaluated and may include
the use of phytochemicals in daily lifestyle. In the present perspective, we discussed
one of the potent phytochemicals, that has been used over the past few decades known as
curcumin as a panacea drug of the “Cure-all” therapy concept. In our review firstly we included
exhausted data from in vivo and in vitro studies on breast cancer, lung cancer, and
liver cancer which act through various cancer-targeting pathways at the molecular level.
Now, the second is the active constituent of turmeric known as curcumin and its derivatives
are enlisted with their targeted protein in the molecular docking studies, which help the researchers
design and synthesize new curcumin derivatives with respective implicated molecular
and cellular activity. However, curcumin and its substituted derivatives still need to
be investigated with unknown targeting mechanism studies in depth.
Ultrasound-assisted Synthesis of Biologically Promising Organoselenium Scaffolds
Authors: Banerjee Bubun , Singh Arvind , Sharma Aditi , Priya Anu , Kaur Manmeet , Kaur Gurpreet
Published: May 2023

Selenium metal acts as an essential nutrient in many selenoproteins. Various selenium-
containing compounds are reported to possess a broad range of biological activities. In
many commercially available drug molecules, selenium plays an important role. As a result,
during the last two decades, organoselenium chemistry has expanded widely. A huge number
of methods have been reported for the synthesis of structurally diverse organoselenium compounds
under various reaction conditions. On the other hand, ultrasound-assisted protocols
are found much more advantageous over traditional thermal methods in terms of reaction
times, yields, product selectivity, purity of the products etc. In many occasions, it was found
that ultrasound plays a pivotal role in achieving the desired products in high yields. In this
review, we have summarized the recent literature on the ultrasound-assisted synthesis of various
organoselenium scaffolds under diverse reaction conditions.
The DNMT3B Inhibitor Nanaomycin A as a Neuroblastoma Therapeutic
Agent
Authors: Izumi Kazuya , Aoki Hiromasa , Kakita Hiroki , Takeshita Satoru , Ueda Hiroko , Inoue Yasumichi , Hayashi Hidetoshi , Yamada Yasumasa , Aoyama Mineyoshi
Published: May 2023

Background:

Neuroblastoma is one of the most common childhood solid tumors. Because
tumor suppressor genes are often hypermethylated in cancers, DNA methylation has emerged as a target
for cancer therapeutics. Nanaomycin A, an inhibitor of DNA methyltransferase 3B, which mediates
de novo DNA methylation, reportedly induces death in several types of human cancer cells.

Objective:

To study the antitumor activity of nanaomycin A against neuroblastoma cell lines and its
mechanism.

Methods:

The anti-tumor effect of nanaomycin A on neuroblastoma cell lines was evaluated based on
cell viability, DNA methylation levels, apoptosis-related protein expression, and neuronal-associated
mRNA expression.

Results:

Nanaomycin A decreased genomic DNA methylation levels and induced apoptosis in human
neuroblastoma cells. Nanaomycin A also upregulated the expression of mRNAs for several genes related
to neuronal maturation.

Conclusions:

Nanaomycin A is an effective therapeutic candidate for treating neuroblastoma. Our
findings also suggest that the inhibition of DNA methylation is a promising anti-tumor therapy strategy
for neuroblastoma.
The Mutation and Low Expression of ARID1A are Predictive of a Poor
Prognosis and High Immune Infiltration in Triple-negative Breast Cancer
Authors: Wang Yuejing , Chen Zhuo , Wu Jing , Yan Hong , Wang Yiran , He Jie
Published: May 2023

Background:

Triple-negative breast cancer (TNBC) has the poorest prognosis among all
breast cancer subtypes. While several tumor types are excepted to have a curative response to immunotherapy
through the AT-rich interaction domain 1A (ARID1A) gene, its role in TNBC remains unclear.

Methods:

The expression of the ARID1A gene and immune infiltration in TNBC were analyzed by
way and function enrichment analysis. Additionally, 27 gene mutations, including ARID1A mutation,
were detected in paraffin-embedded TNBC specimens and normal breast specimens using Next Generation
Sequencing (NGS). Immunohistochemical staining was employed to detect the expression of
AIRD1A, TP53, Ki67, CD4, CD8, and PD-L1 proteins in TNBC and the adjacent normal tissue samples.

Results:

The bioinformatics analysis revealed that ARID1A was mutated in TNBC and significantly
associated with tumor immune infiltration. NGS analysis showed a high mutation rate of ARID1A
(35%) in TNBC, but the mutation status of ARID1A was not associated with age at onset, lymph node
metastasis, pathological grade, or Ki67 index. Low expression or loss of AIRD1A was more commonly
observed in TNBC tissues (36/108) as compared to normal tissues (3/25). Positive expression of
CD8 and PD-L1 was observed in TNBC tissues with low ARID1A expression. ARID1A mutation was
associated with low protein expression, and patients with ARID1A mutation or low protein expression
had shorter progression-free survival.

Conclusion:

The ARID1A mutation and low expression are associated with poor prognosis and high
immune infiltration in TNBC, and might be biomarkers for TNBC prognosis and immunotherapy efficacy.
The FJQR Has Synergistic Effect with Fluoropyrimidine in the Maintenance
Treatment for HER-2 Negative Gastric Cancer
Authors: Kong Fanming , Zhao Lu , Wang Na , Zhang Dou , Wang Ziwei , Mei Qingyun , Yu Yongchao , Jia Yingjie
Published: May 2023

Introduction:

Maintenance therapy aimed to strengthen the first-line chemotherapy and
improve quality of life is needed for gastric cancer (GC). Currently, many clinical studies have
confirmed the important role of fluoropyrimidine in the maintenance stage. Our team has created
patented prescriptions “Fuzheng jiedu Quyu Method” recipe (FJQR), which was considered as an
adjuvant therapeutic scheme (reduce toxicity and increase the efficacy of chemotherapy). This
study aimed to evaluate the efficacy and safety of FJQR combined with fluoropyrimidine as a
maintenance treatment in HER-2 negative GC patients.

Methods:

We performed the analysis of 129 patients with HER-2 negative GC who entered the
maintenance stage in our hospital and Tianjin Cancer Hospital between January 2018 and December
2020. Out of the 129 eligible patients, 64 were categorized into the maintenance treatment
group with FJQR+fluoropyrimidine, and 65 patients were assigned to the control group if they
received fluoropyrimidine alone. Capecitabine was orally 1000mg/m2, Qd, half an hour after
meals, and FGQR was 15g Bid after capecitabine. The primary endpoint was progression-free survival
(PFS). The secondary endpoints were overall survival (OS), overall remission rate (ORR),
quality of Life (QOL), TCM syndrome and safety.

Results:

The mPFS in the treatment group was significantly prolonged compared with the control
group (6.3 vs. 5.0 months, p = 0.03), while the mOS was not substantially improved (11.4 vs. 10.5
months, p = 0.38). Gastrointestinal symptoms and pain became better in the treatment group. The
number of distant metastatic organs, first-line chemotherapy cycles, and lymph node metastasis
were independent risk predictors for PFS. Blood stasis syndrome may be the protective factor. In
terms of safety, treatment-related adverse events (AEs) in the treatment group were relatively
lighter, and the incidence of grade III-IV AEs could be significantly reduced.

Conclusion:

FJQR and fluoropyrimidine have synergistic effects as maintenance treatment in
HER-2 negative GC, with good efficacy and safety.
Lipid Profiles and Atrial Fibrillation in Ischemic Stroke Patients Treated
with Thrombectomy: Experience from a Tertiary Italian Stroke Hospital
Authors: Bravi Maria Cristina , Pilato Fabio , Crupi Domenica , Mangiardi Marilena , Pezzella Francesca Romana , Siniscalchi Antonio , Cotroneo Enrico , Bertaccini Luca , Alessiani Michele , Anticoli Sabrina
Published: May 2023

Objectives:

To assess acute lipid profiles, atrial fibrillation and other cardiovascular risk
factors in patients undergoing treatments by thrombectomy (EVT) with acute ischemic stroke
(AIS).

Methods:

We performed a retrospective analysis of the lipid profile and vascular risk factor in
1639 consecutive patients with acute ischemic stroke between January 2016 and December 2021.
To assess lipid profiles, laboratory tests, including total cholesterol (TC), low-density lipoprotein
cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG), were
obtained the day after admission. We also examined the association between lipid profile, AF and
EVT in multivariate logistic regression analysis.

Results:

Median age of patients was 74 years, 54.9% were males (95% CI 52.5-57.4%), and
26.8% (95% CI, 24.7-29.0%) had AF. EVT patients (n = 370; 22.57 %; 95% CI, 20.6-24.7)
showed no difference in age (median 73 years (IQR; 63-80) versus 74 years (IQR; 63-82)),
HbA1c levels (median 5.8 (IQR; 5.4-6.2) versus 5.9 (IQR; 5.4-6.4)), TG/HDL ratio (median 2.40
(IQR; 1.65-3.48) versus 2.51 (IQR; 1.73-3.64)), diabetes (OR 0.82; 95% CI 0.61 to 1.08), hypertension
(OR 0.87; 95% CI 0.68 to 1.12) and obesity (OR 1.06; 95% CI 0.78 to 1.42) compared to
non-EVT patients. Conversely, EVT patients showed lower levels of TC (160 mg/dl (IQR; 139-
187) versus 173 mg/dl (IQR; 148-202); p <0.001), LDL-C (105 mg/dl (IQR; 80-133) versus 113
mg/dl (IQR; 88-142); p <0.01), TG (98 mg/dl (IQR; 76-126) versus 107 mg/dl (IQR; 85-139); p
<0.001), non-HDL-C (117 mg/dl (IQR; 94-145) versus 127 mg/dl (IQR; 103-154); p <0.001), HC
(8.3 mmol/l (IQR; 6-11) versus 10 mmol/l (IQR; 7.3-13.5); p <0.001) than non-EVT patients.
Multivariate logistic regression analysis showed an independent association of EVT with TC (OR
0.99, 95% CI 0.98-0.99), AF (OR 1.79, 95% CI 1.34-2.38), age (OR 0.98, 95% CI 0.96-0.99), and
NIHSS (OR 1.17, 95% CI 0.14-1.19).

Conclusion:

Total cholesterol and all cholesterol-related measures were significantly lower in patients
undergoing thrombectomy than in other stroke patients. Conversely, we found that AF was
significantly high in patients with EVT, suggesting that hypercholesterolemia could be mainly
linked to small-vessel occlusion stroke while large vessel occlusion (LVO) stroke could show different
causes. AIS patients may have different pathogenesis and their understanding may improve
the discovery of specific and tailored preventive treatments.
Integrated Bioinformatics Approach for Disclosing Autophagy Pathway as a Therapeutic Target in Advanced KRAS Mutated/Positive Lung Adenocarcinoma
Authors: Dodin Yasmeen
Published: May 2023

Background:

Lung cancer is the leading cause of cancer-related deaths, accounting for 1.8 million deaths (18%). Nearly 80%-85% of lung cancer cases are non-small cell lung cancers (NSCLC). One of the most frequent genetic mutations in NSCLC is the Kirsten Rat Sarcoma Oncogene Homolog (KRAS) gene mutation. In recent years, autophagy has drawn substantial attention as a potential pathway that can be targeted in cancer driven by KRAS gene mutation to efficiently improve the therapeutic profile of different treatments.

Methods:

In this study, we have investigated the potential of targeting the autophagy pathway as a treatment approach in advanced KRAS-mutated lung adenocarcinoma using gene expression data from The Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) project.

Results:

Compared to KRAS wild-type lung adenocarcinoma, there were found 11 differentially expressed autophagy-related genes (DEARGs), with 5 upregulated and 6 downregulated DEARGs (threshold of adjusted p-value <0.05).

Conclusion:

These DEARGs can be investigated as potential genes that can be targeted by different autophagy inhibitors.
A PARTICIPAÇÃO DA OAB NA ASSEMBLEIA CONSTITUINTE DE 1987-1988 E A DINÂMICA DE SEUS INTERESSES
Authors: Pellegrino Vinny , Lima Jairo
Published: May 2023

A partir do reconhecimento da existência de uma dualidade de interesses da Ordem dos Advogado do Brasil, de um lado interesses corporativos e, de outro, interesses gerais/nacionais, a presente pesquisa se desenvolveu buscando demonstrar como se deu a dinâmica desses interesses na Assembleia Nacional Constituinte (ANC) de 1987-88. Para tanto, foram realizados dois movimentos, ambos por meio de uma abordagem metodológica histórico-documental: na primeira seção, foi investigada a participação e a influência da OAB na apresentação de sugestões e emendas na ANC; na segunda seção, foram analisados os anais das audiências públicas que tiveram a OAB como expositora externa. Ao final, a pesquisa contribuiu para uma melhor compreensão da dinâmica de interesses da OAB no processo constituinte ao demostrar que o fortalecimento da entidade decorreu tanto de sua colaboração com assuntos de interesse geral/nacional quanto do fato de ter conseguido incluir no texto da Constituição de 1988 seus interesses corporativos.
RAMO RECONSTRUTIVO, MINICONSTITUIÇÕES E BYPASSES INSTITUCIONAIS:
Authors: De Lara Gustavo Dalpupo , De Chueiri Vera Karam
Published: May 2023

O objetivo geral deste artigo é desenvolver as bases teóricas e normativas de estratégias institucionais que possam contribuir para inibir a prática do constitucionalismo abusivo por emendamento constitucional. Seu objetivo específico é demonstrar a compatibilidade entre os conceitos de miniconstituição e bypass institucional como passo inicial em favor da expectativa indicada pelo objetivo geral. São apresentados os elementos primários de modelo de desenho institucional que imporia à técnica de emendas à Constituição um rito alternativo inspirado no experimentalismo democrático. A hipótese central da pesquisa, sustentada pela literatura que a informa, é de que o emprego desse rito, internamente a esquema de reorganização e multiplicação dos ramos de governo, criaria obstáculos adicionais inibitórios ao emendamento abusivo. Nesse sentido, propõe-se que um desses ramos deva encarregar-se da tarefa de supervisionar, aprovar ou rejeitar a instituição de regimes constitucionais especiais (as miniconstituições), a serem executados na forma de bypasses institucionais. A pesquisa é teórica e explora de forma interpretativa ou qualitativa os conceitos que informam seu objeto. Ainda, é exploratória e exclusivamente bibliográfica. Seus resultados e conclusões são apresentados na forma de proposições normativas, as quais abrem caminho para investigação analítica adicional e convidam teste empírico de suas hipóteses.
Een herbeschouwing van het West-Europese multiculturele debat in een ‘post-truth’-context
Authors: Seutin Anémone , Hannes Karin
Published: May 2023

This article presents the findings of a qualitative literature review on the central questions in the Western-European “multicultural debate”, with specific regard for the Belgian region. The multicultural debate is defined as the public discussion on problems that are rightly or wrongly linked to the fact of living together in a culturally diverse context. The four key domains that are identified in this debate are the following: (im)migration, integration, discrimination/racism and the place of religion/Islam. This article attempts to offer an overview of the answers provided by the scientific literature within each of these domains. The main conclusion is that although there is undeniably a large volume of (raw) data available, especially with regard to migration and integration, the central questions in this debate are only to a very limited extent being answered with sound empirical findings. This makes it more difficult to reach a scientific consensus on these questions. Meanwhile, many have pointed out the series of political and societal shifts that have taken place in several western countries as a new “post-truth” era in which truth, facts and rationality no longer matter. As these developments have once again placed diversity and multicultural issues at the centre of public discourses and the collective imaginary, possible implications of the findings of this study in this context are discussed.
Tewerkstellingskwaliteit, gezondheid en welzijn voor werknemers en zelfstandigen
Authors: Gevaert Jessie , Van Aerden Karen , De Moortel Deborah , Vanroelen Christophe
Published: May 2023

At the beginning of the 21st century, the standard employment relationship (SER) is no longer the only dominant form of organizing labour. Instead, a variety of employment arrangements have appeared, both for the waged and self-employed. It is, however, unclear how this relates to health consequences. This is why, we introduce a multidimensional account of employment quality as a health determinant. We ran two latent class cluster analyses to construct typologies of employment quality (using the European Working Conditions Survey); one for the waged employed and one for the self-employed. These typologies were then merged into one composite indicator. Ten types of employment quality were revealed: SER-like, instrumental, precarious unsustainable, precarious intensive and portfolio jobs – among the waged employed; and dependent, insecure and intensive self-employment, small to medium sized employers, and stable own account work – among the self-employed. By applying a multidimensional account and considering the employment quality of both the waged and self-employed, we have moved beyond simple distinctions of waged versus self-employment. Using logistic regression analysis, we furthermore found strong associations between the typology of employment quality and health outcomes. The worst health and well-being were found among insecure, dependent, and intensive self-employment, and among precarious intensive and precarious unsustainable jobs. We found worse health outcomes for the self-employed with poor employment quality compared to the waged employed with poor employment quality. The study shows that employment quality should be taken seriously as a health determinant and is equally applicable to the waged and the self-employed.
Downward Accountability as a Tool to enhance Malaysian NPO's Effectiveness
Authors: Abdullah Hadi Hasnatulsyakhira , Bakar Ahmad Naqiyuddin , Mohd Noor Nurul Hidayana , Ashfahany Afief El
Published: May 2023

The important role of nonprofit organisations (NPO) as service providers, they have been demanded to prove their accountability towards their stakeholders. Downward accountability mechanism is believed can improve NPO effectiveness. This paper aims to assess the relationship between information disclosure and participation mechanism with NPO effectiveness. This study will employ a quantitative research strategy, and it will be a cross-sectional survey. The instrument that will be used is a structured questionnaire that involved 214 staff from welfare NPOs in the Klang Valley, Malaysia and analysed using Structural Equation Modeling (SEM). The findings will give better insight into the Malaysian third sector.
Revised Development of LEO/SKiPP on Worker's Mental Health Status
Authors: Masuri Mohamad Ghazali , Md Isa Khairil Anuar , Mustafa Rusmawati , Victor Paulraj Smily Jesu Priya
Published: May 2023

Occupational therapists usually use assessment and screening forms that can identify the problems faced by the person. In the field of return to work, the initial assessment is usually used to get an overview of a problem faced by the employee, both physically and mentally. This study explores the potential screening and reporting used using the Likelihood Scale of Environment & Occupation (LEO) or is also known as Skala Kemungkinan Persekitaran & Pekerjaan (SKiPP), related to local industry in Malaysia. The re-evaluation of the LEO/SKiPP screening is done to report the latest developments in the development of the instrument.
Examining the Well-being of Citizens' Satisfaction: Comparing smart cities in Malaysia and China
Authors: Chong Kim Mee , Subramaniam Geetha , Zhou Bingran , Separa Lenis Aislinn C.
Published: May 2023

In the digital era, smart cities are a potential solution as cities get more crowded and complex. This study investigates and assesses whether citizens' well-being is promoted by developing a smart city, consistent with Sustainable Development Goals 3 and 11. Online questionnaires were distributed to 105 and 134 citizens residing in Malaysia and China's smart cities respectively. Data was analysed using a structural equation modelling technique (SEM). This research supports the theoretical underpinnings of how smart cities are considered to be developed and the importance of citizen satisfaction as a mediator when evaluating citizens' well-being.
Examining the Phenomenon of Juveniles Digital Addiction in Rural China
Authors: Gao Xinxiang , Raja Thillai , Chong Kim Mee , Wu Meng
Published: May 2023

Digital addiction among China's rural juveniles escalates and hampers the harmony and stability of families and society. This paper investigates digital addiction among rural juveniles in China. Semi-structured interviews selected six relevant respondents in rural Shaanxi Province as samples. The study explores the degree, characteristics, causes, effects, and prevention and control of rural juveniles' digital addiction. The findings reveal the importance of digital literacy education, parent-child cognitive dislocation, and the complexity of rural juveniles' digital addiction. The study has limitations, including its limited research perspective and the need for more typical cases for analysis and discussion.
Current Physiotherapy Approaches for Patellofemoral Pain Syndrome: A systematic review
Authors: Fuhad Aslinda , Zahari Zarina , Justine Maria , Wen Qiang Sun
Published: May 2023

Background PFPS is a common knee-flexion-induced pain among young people who attend physiotherapy. Significant This study focused on PT management on PFPS. Methods The papers were retrieved via an electronic search of year-round databases. The McMaster Critical Review Form for Quantitative Research and the Cochrane (EPOC) were utilised for quality and risk assessments. Limitations Small evidence on Blood flow restrictions, kinesiophobia, and patient education could be due to lack of investigation. Findings More trials on the effect of various types of PFPS intervention. Implications Physiotherapy improves pain, physical function, and kinesiophobia, but further research is needed for clinicalÂ applicability.
Relationship of Cognitive Ability and Self-Confidence in Driving Activities among Post-Stroke Survivors
Authors: Mohd Poot Erna Faryza , Murad Mohd Suleiman , Idriani Nur Afifah , Vetrayan Jayachandran
Published: May 2023

Evidence on cognitive abilities and driving activity's self-confidence associated with difficulty in performing driving among post-stroke patients is still insufficient. Therefore, the cross-sectional study was conducted to investigate the association between post-stroke survivors' cognitive abilities and driving activity's self-confidence among post-stroke patients. The findings indicated a significant association (p<0.05) between cognitive ability with age and driving status. Moreover, driving status shows a significant association (p <0.05) with self-confidence. Therefore, an occupational therapist must conduct an off-road evaluation identifying an individual's cognitive capacity and self-confidence associated with the post-stroke patient's driving performance.
Type of Sitting Posture and Low Back Pain among University Students
Authors: Zahari Zarina , Arnuin Nurul Amira , Mohd Fuhad Aslinda Maulat , Lin Pipeng
Published: May 2023

Background: Prolonged sitting may cause faulty posture among students leading to low back pain (LBP). Objectives: 1. To compare the time spent sitting among students with and without LBP. 2. To determine the association between types of sitting posture and LBP. Methods: This cross-sectional online survey recruited 420 students. Findings: A majority (56%) of 343 respondents seated >10 hours daily. There was a significant total time spent between students with and without LBP. However, there was no association between types of sitting posture and LBP. Implications: Awareness of avoiding prolonged sitting should be emphasized among the students to minimize LBP.
Economic Security, Sanctions and Reorientation of Russian Foreign Trade Flows
Authors: Anisimova Y. A. , Plotnikov V. A.
Published: May 2023

Relevance. Under the conditions of sanctions pressure, Russia needs to protect its economic interests and strengthen economic security. Therefore, the reorientation of foreign trade flows requires additional analysis. The purpose is to consider the direction of reorientation of Russian foreign trade flows in the context of anti‒ Russian sanctions.

Objectives: to determine the main agenda of world trade policy; to identify common priorities of world trade; to provide quantitative data on the volume of trade of countries, to analyze the specifics of trade agreements over a decade, to identify the main economic method of pressure on states; to provide data on Russia's trade with other countries; to consider the Russian export commodity structure; to identify the relationship between the share in the commodity structure goods and growth rates in stable and crisis periods; identify priority export Russian goods in modern conditions.

Methodology. The research methodology included the use of methods of analysis of quantitative and qualitative characteristics, correlation analysis, description, retrospective analysis, abstraction, generalization of the analyzed information.

Results. The reasons for the forced change in the direction of foreign trade flows are not only direct pressure on the Russian economy, but also global trends of deglobalization and regionalization. The current trading partners, despite the restrictions imposed, continue to trade with Russia. When finding potential allies, the focus is primarily on the reliability, security and strength of partners on the world stage. The Russian economy should not deviate from the current export structure, as the demand for energy resources continues to be high. And Russia retains the role of one of the guarantors of global energy security.

Conclusions. The issue of reorientation of Russian trade flows to alternative directions will remain one of the prevailing ones today. This is able to stabilize the economy and protect the economic interests of the country, to ensure the economic security of Russia. By diversifying and transforming trade flows by changing channels, the Russian economy will be able to discover new opportunities for the development of the world market.
A Modern Approach to the Selection and Implementation of an ERP System at an Enterprise as an Effective IT Solution in Business Management
Authors: Tronina I. A. , Semenikhina A. V. , Tatenko G. I. , Morozova O. I.
Published: May 2023

Relevance. A modern enterprise as a complex socio-economic system exists today in the mode of constant changes to adequately respond to the challenges of the external environment. The development of production and personnel potential, the growth of profitability, and the improvement of competitiveness are the key objectives of the strategic development of the enterprise, which requires the optimization of its business processes, the reorganization of work with business partners, customers, and employees. Hence, there is a need for systematic business renewal through the introduction of new IT products.

The purpose is a theoretical and methodological justification of the need to integrate an ERP system into the current activities of a modern enterprise in the face of environmental challenges. The objectives: to consider the possibilities and mechanism of implementing an ERP system for the functioning and development of enterprises; to investigate the key elements of an ERP system for building a modern IT architecture of an enterprise in accordance with the principles of digitalization; to highlight the advantages and disadvantages of classical and flexible approaches in the ERP-system implementation project.

Methodology. Methods of statistical and comparative analysis, illustrative-graphical method, methods of generalization and logic based on a systematic approach are used in the work.

Results. In the course of the study, it was found that the problems of implementing an ERP system in the activities of a modern enterprise must be solved on the basis of a project approach involving the use of mechanisms of both the traditional Waterfall methodology and the Agile methodology. The main thing is to understand the potential opportunities and assess the expected risks when making decisions about the implementation of an IT product.

Conclusions. The introduction of an ERP system in an enterprise will improve and optimize business processes, focus on the competence abilities of line managers and employees. This is important in order to get the most out of the potential of an ERP system. The starting point is the process of developing and implementing standards of work with a clear description of the desired result. At the same time, the project team should pay considerable attention to changing the mentality and behavior of employees with ongoing changes in the motivation system and organizational culture.
Avoiding a Grim Future: The Climate Crisis and Its Effects on Human Aggression and Violence
Authors: Miles-Novelo Andreas , Anderson Craig A.
Published: May 2023

As the climate crisis has progressed, scientists have begun to ask, "How does a rapidly warming ecosystem impact human behavior?" As aggression scholars and non-professional environmentalists, it has become increasingly clear that the impact of the climate crisis, without intervention, will dramatically increase humans' exposure to risk factors known to cause aggressive and violent behavior. This article describes a model that explains the indirect and direct effects of the climate crisis on aggression and violence, both on an individual level and broadly on group dynamics. We propose that systemic and global intervention strategies must be adopted to mitigate the severity of the climate crisis. This manuscript outlines the research demonstrating how climate change will increase human aggression and violence and then discusses potential interventions, such as holistic policies addressing immigration and income inequality. In discussing this topic, we provide insight into the intersectional nature of the consequences of rapid global warming.
Uso de Lecanicillium lecanii para el control de la mosca blanca Bemisia tabaci en algodón y berenjena
Authors: Villamizar Laura , Espinel Carlos , Varón Edgar , Jiménez Nora , Zuluaga María , Grijalba Érika , Santos Adriana , Cruz Mauricio
Published: May 2023

Dentro de las especies de moscas blancas, a nivel mundial sobresale por su importancia económica Bemisia tabaci (Gennadius), debido a su amplia distribución geográfica, al daño directo e indirecto que ocasiona y al gran número de culti vos que afecta (Rodríguez y Cardona, 2001).
Supporting Adolescent Engagement with Artificial Intelligence–Driven Digital Health Behavior Change Interventions (Preprint)
Authors: Giovanelli Alison , Rowe Jonathan , Taylor Madelynn , Berna Mark , Tebb Kathleen P , Penilla Carlos , Pugatch Marianne , Lester James , Ozer Elizabeth M
Published: May 2023

UNSTRUCTURED

Understanding and optimizing adolescent-specific engagement with behavior change interventions will open doors for providers to promote healthy changes in an age group that is simultaneously difficult to engage and especially important to affect. For digital interventions, there is untapped potential in combining the vastness of process-level data with the analytical power of artificial intelligence (AI) to understand not only how adolescents engage but also how to improve upon interventions with the goal of increasing engagement and, ultimately, efficacy. Rooted in the example of the INSPIRE narrative-centered digital health behavior change intervention (DHBCI) for adolescent risky behaviors around alcohol use, we propose a framework for harnessing AI to accomplish 4 goals that are pertinent to health care providers and software developers alike: measurement of adolescent engagement, modeling of adolescent engagement, optimization of current interventions, and generation of novel interventions. Operationalization of this framework with youths must be situated in the ethical use of this technology, and we have outlined the potential pitfalls of AI with particular attention to privacy concerns for adolescents. Given how recently AI advances have opened up these possibilities in this field, the opportunities for further investigation are plenty.