bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAN SEKOLAH INKLUSI TERHADAP TUMBUH KEMBANG ANAK AUTISME
Authors: Rieskiana Fahmi
Published: November 2021

This study aims to determine the role of inclusive schools on the growth and development of children with autism. This research is a literature study by reviewing book references, journal articles and social media if necessary. From the data that has been collected, the next step is to analyze it so that conclusions can be easily drawn. The results show that Autism is a developmental disorder in children who are unable to communicate and express their feelings and desires. Usually this disorder is seen before the age of 3 years. People with Autism really need educational services that can accommodate, complete, the facilities and infrastructure they need, such as in inclusive schools. In inclusive schools, children with autism can learn independently and develop their ability to communicate and develop social interaction skills, namely communicating well with their peers. So that for people with autism, the role of inclusive schools is needed by handling, facilities and infrastructure in an effort to develop the development of autistic children.Keywords: Development, autism, early childhood
KONSEP MANAJEMEN PENDIDIKAN KARAKTER DALAM MENUMBUHKAN AKHLAKUL KARIMAH DI MTS RAUDHATUL ISLAMIYAH KEMIRI
Authors: A Asnawati
Published: November 2021

This paper discusses the concept of management of character education in MTs Raudhatul Islamiyah Kemiri, the concept in question is the pattern of character growth of students with various supporting elements such as madrasa activities, rules or regulations, and content of Islamic education lessons that are applied in MTs Raudhatul Islamiyah Kemiri. In addition to these supporting elements, in order to grow the character of morality also has several strategies in supporting the achievement of character education management concepts such as: exemplary, learning, empowerment and acculturation, retention, and assessment. At this time Character becomes important for human life, especially for the next generation of nation. Therefore character education becomes important in school. However, the achievement of character values must be applied with good management. Character education management is a planned effort to make learners recognize, care and internalize the values so that learners are able to grow its character that consists of the process of planning, organizing, implementation and supervision.
IMPLEMENTASI NILAI-NILAI PANCASILA DALAM ERA “NEW NORMAL”
Authors: Mirnawati Sri
Published: November 2021

The Covid-19 pandemic that Indonesia has been facing since March 2020 requires well-planned handling to deal with this new normal or new normal. Adopt health protocols that are in accordance with World Health Organization (WHO) directives that apply globally to strengthen community resilience in the face of the Covid-19 pandemic. Through various policies that have been established by the Government of Indonesia to respond to this Covid-19 pandemic health disaster. The level of transmission and spread of Covid-19 is still increasing and there has not been a significant decrease because the implementation of policies that handle Covid-19 which refers to WHO directives are still faced with many problems so that the handling is still not optimal and effective. Therefore, it is necessary to change the approach to handling the Covid-19 pandemic which is based on the values of Pancasila as a view of the life philosophy of the nation and the Indonesian people when viewed from the perspective of national interests, which is expected to increase the useful results of the efforts to handle the Covid-19 pandemic carried out by the Government. The implementation of Pancasila values in handling the Covid-19 pandemic can create a new normal or a new normal that is free from Covid-19.
Peran pustakawan dalam menyiapkan generasi emas: implementasi literasi informasi di SD Muhammadiyah Sapen Yogyakarta
Authors: Nurhayati Anna
Published: November 2021

Introduction. The golden generation is a generation that is able to compete globally with comprehensive intelligence, including productive, innovative, peaceful in social interactions, healthy and healthy in natural interactions, and superior civilization.Data Collection Method. This type of research is qualitative. Data were collected by in-depth interviews and direct observation. The validity of the data was tested through data triangulation.Analysis Data. The data is discussed with the big6 model of information literacy theory. Data analysis using library research method or literature study.Results and Discussion. Information literacy is the ability to recognize information needs and when information is needed, identify and locate information, evaluate information critically. Information literacy is one way to form a golden generation in the school environment. The big6 literacy model has 6 effective steps that can be used to solve problems, namely; task definition; information seeking strategies; location and access; use the information; synthesis; and evaluation.Conclusions. Implementation of this model requires planning methods and instructor competence. Implementation of information literacy at SD Muhammadiyah Sapen Yogyakarta in the form of library research that produces student work in the form of mini books
Pengembangan Lembar Kerja Peserta Didik Elektronik Berbasis Flipbook Pada Mata Pelajaran Ekonomi Kelas XI
Authors: Nufus Virda Fithrotun , Sakti Norida Canda
Published: November 2021

Penelitia ini bertujuan untuk megembangkan Lembar Kerja Peserta Didik elektronik dengan menggunakan flipbook dan mendeskripsikan kelayakan, kepraktisan, dan keefektifan penggunaannya. Model pengembangan 4D dari Thiagarajan, meliputi pendefinisian, perancangan, pengembangan. Subjek uji coba penelitian merupakan peserta didik kelas XI MIA 6 SMAN 2 Lamongan sebanyak 20 orang. Hasil penelitian diperoleh bahwa  Lembar Kerja Peserta Didik elektronik berbasis flipbook layak, praktis, dan efektif untuk digunakan sebagai bahan ajar dengan perolehan kelayakan produk 81,45% sangat layak, kepraktisan produk melalui respon peserta didik sebesar 95% sangat layak, keefektifan dengan presentase ketuntasan hasil belajar sebesar 80%.
Analisis Hubungan antara Religiusitas dan Lingkungan Sekolah Terhadap Motivasi Belajar Siswa Kelas XI SMA NU Bancar
Authors: Thohir Lu'lu'ul Khusnanut , Rafsanjani Mohamad Arief
Published: November 2021

Menurunnya motivasi belajar menjadi salah satu faktor yang dapat menghambat kegiatan pembelajaran. Tujuan dilaksanakannya Penelitian ini adalah Untuk mengetahui pengaruh religiusitas serta pengaruh lingkungan sekolah terhadap motivasi belajar siswa. Penelitian ini tergolong dalam penelitian yang berjenis kuantitatif dengan menggunakan metode penelitian ex post facto. Penelitian ini memiliki populasi yang berasal dari seluruh peserta didik kelas XI di SMA NU Bancar dengan metode sampling jenuh sehingga seluruh peserta didik yang ada kelas XI SMA NU Bancar dilibatkan menjadi sampel penelitian yang berjumlah 46 siswa. Teknik analisis data dalam penelitian ini menggunakan uji regresi linier berganda. Setelah melalui proses pengujian diperoleh hasil hasil penilaian (1) Variabel Religiusitas memiliki pengaruh positif dan signifikan terhadap variabel Motivasi belajar pada peserta didik kelas XI SMA NU Bancar. (2) Variabel Lingkungan Sekolah memiliki pengaruh positif dan signifikan terhadap variabel Motivasi Belajar pada peserta didik kelas XI SMA NU Bancar.
„Klima nervt!“ – Zum didaktischen Umgang mit Widerständen bei der Thematisierung des Klimawandels im Religionsunterricht
Authors: Schimmel Alexander , Krahn Annika
Published: November 2021

Ökologische Problemstellungen, insbesondere der Klimakrise, nehmen zunehmend größeren Raum in öffentlichen Debatten und Diskursen ein. Dabei zeigen sich divergierende gesellschaftliche Positionen in der Bewertung der Relevanz und der zu ergreifenden Gegenmaßnahmen. Wie in der Gesellschaft, so zeigen auch Schüler*innen im Religionsunterricht ein heterogenes Tableau an Einstellungen. Der Beitrag beleuchtet Einstellun­gen, die einer hohen (Lern-)Motivation entgegenstehen und offeriert (religions-)didaktische Umgangsweisen.
Development of Electronic Modules Based on STEM to Train Students' Creativity: Validity and Practicality Analysis
Authors: Melisa Melisa , Susilowati Eko , Dewantara Dewi
Published: November 2021

The STEM-based electronic module is a systematic presentation of learning materials to support students' independence with an approach in four fields of knowledge: science, technology, engineering, and mathematics. This study aims to describe the feasibility of this STEM-based electronic module to train students' creativity. The specific objectives of this study are to describe: (1) The validity of the STEM-based electronic physics module; and (2) The practicality of the STEM-based physics electronic module. The type of research was ADDIE, with the subject of the trial of 27 students at class X Science-1 in a public high school in Banjarmasin City, South Kalimantan, Indonesia. Data collection was obtained from observations, interviews, questionnaires, and tests. This research was analyzed qualitatively and quantitatively. The research results showed that: (1) the validity of the STEM-based electronic physics module was in a "very good" category, and (2) The practicality based on the implementation of the Lesson plan was categorized as "moderately practical". The existing STEM-based electronic physics modules (Science, Technology, Engineering, and Mathematics) to train students' creativity are still not suitable for learning. So, it can be concluded that the STEM-based physics electronic module is feasible to train students' creativity, and the direct result of this research was that educators could evaluate methods and media that support online learning more effectively for each meeting, and the results of this study can be used as input for teachers and teacher candidates. The next step of this research is to apply methods, learning models that support STEM and sufficient time to train students' creativity which is expected to be applied to face-to-face learning.
Feasibility of Physics Teaching Materials With Qur'an Using Generative Learning Model on Sound Waves
Authors: Lutfi Muhammad , Zainuddin Zainuddin , Susilowati Eko
Published: November 2021

Preliminary observations show the limitations of teaching materials that have a relationship with spiritual aspects, especially the Qur'an, which is due to the limitations of teaching materials that contain these aspects. Required learning that stimulates students to generalize religious aspects and learn physics. Therefore, the purpose of this study is to describe the feasibility of physics teaching materials containing the Qur'an by using a generative model on sound wave material. This study aims to describe the validity, practicality, and effectiveness of the teaching materials developed. The research was conducted on 33 students at class XI MIPA 1 MAN 2 Model Banjarmasin using the ADDIE model. Data was taken from the validation results of teaching materials using validation sheet, lesson plan implementation using lesson plan implementation sheet, and students' learning outcomes at the pretest and post-test using learning outcomes tests. The results of this study were 1) the validity of the teaching materials was in the "valid" category with a value of 3.33, 2) the practicality of the teaching materials was in the "very practical" category with a value of 3.63, and 3) the effectiveness of the teaching material was in the "effective/moderate" category with a value of 0,44. This study concluded that physics teaching materials containing Al-Qur'an verses on sound wave materials using generative learning models are declared feasible to be used based on the validity, practicality, and effectiveness of the teaching materials. The implication of this research is the creation of teaching materials containing the Qur'an that are used in schools and creating student habits to link physics and the Qur'an.
Development of a Science Module on Temperature and Heat Topics to Improve Critical Thinking and Collaboration Skills
Authors: Aufa Mohamad Nor , Hadi Sutarto , Syahmani Syahmani , Rusmansyah Rusmansyah , Hasbie Muhammad , Isnawati Isnawati
Published: November 2021

This study aims to produce a science module based on mobile-collaborative-based science learning (m-CBSL) with the topic of temperature and heat and describe the resulting module's validity and practicality. The research design was Educational Design Research (EDR). The data collection techniques used were literature study, walkthrough, interview, and questionnaire. The instrument used in this study was a questionnaire of validity and practicality. Data analysis techniques include descriptive data analysis, validation sheets, and questionnaires. Module validation sheets were given to 5 validators. In contrast, practicality sheets were given to 9 students of class VII SMP Negeri 12 Banjarmasin (small group) and 62 students and three science teachers at SMP Negeri 6 & 12 Banjarmasin field test. The validity questionnaire analysis results concluded that the validity of the module was 3.71 "very valid" categories. The practicality level based on the teacher's questionnaire scored 87.04 in the "very practical" category. The small group questionnaire scored 85.19 in the "very practical" category, and the field trial questionnaire scored 86.42 in the "very practical" category. It means that the m-CBSL based science module is valid and practical in the learning process to improve critical thinking skills and collaboration.
Five-Tier Diagnostic Test to Reveal Conceptual Understanding of Electrical Engineering Students
Authors: Setiawan Doni , Jaelani Jaelani
Published: November 2021

The purpose of this research was to produce a valid five-tiered misconception diagnostic assessment product and reveal the understanding of electrical engineering students' concepts on the subject of simple electrical circuits. Assessment development consisted of defining, designing, developing, and disseminating stages. Data collection techniques were online questionnaire methods, online tests, and online interviews. Construct validity was obtained that the assessment was valid and reliable. A total of 19 questions were categorized as medium and one easy question. The analysis of the conceptual understanding test obtained results 29.98% of students who understood the concept, 31.4% did not understand the concept, 2.82% of false positive, 3.38% of false negative, and 31.12% with misconception. There were 26 kinds of student misconceptions identified. The dominant misconception identified in the concept of circuit resistance arrangement was 40.2%. Students assumed that electrons flow from high to low potential in a closed circuit with a DC voltage source. The research results in a five-tier diagnostic assessment can be used in vocational colleges in general. The results of data analysis show that the five-tier format of the assessment can reveal students' misconceptions in detail and, more specifically, distinguish students who have misconceptions from students who are false positive and false negative to reveal students who have misconceptions better. The researcher's development procedure can be used as an example for other researchers to develop a five-tier format diagnostic assessment on other basic concepts.
Development of Teaching Materials in The Form of Comics Based on Local Wisdom Wave Material
Authors: Chercules Chercules , Hakim L , Lefudin Lefudin
Published: November 2021

This study aims to develop teaching materials of comics based on local wisdom of Sriwijaya country on wave material in class VIII SMPN 15 Palembang. The research method used was Research and Development (R&D) with the ADDIE model. The study was only until the stage of Analysis, Design, and Development (ADD). The subject of this research was conducted at SMPN 15 Palembang by involving 11 students of class VIII. This research consists of 3 stages, namely the analysis stage, the design stage, and the development stage. The implementation and evaluation stages were not carried out due to limited research time. Data analysis of student needs was measured through observation activities. The questionnaire was used to determine the feasibility of teaching material products based on expert validation and student responses. This prototype was then validated by construct and content experts from Raden Fatah State Islamic University Palembang and PGRI Palembang University. The results showed that the teaching material product was feasible based on expert validation with the category (80% - 89%) valid and supported by student responses with the category (75.1% - 100%) very practical. Due to time constraints, the problem of productive teaching materials for the implementation and evaluation stages was not carried out. Therefore, this research can be developed or continued in further research that has been studied on the limitation of the problem. It is hoped that researchers can develop this research according to the study of the ADDIE research model until the implementation and evaluation stages are completed.
Inpatient group psychotherapy for addiction patients in times of COVID-19
Authors: Andreu Mondon Magalí , Pons Cabrera María Teresa , Navarro Cortés Lourdes , Barrio Gimenez Pablo
Published: November 2021

Inpatient group psychotherapy for patients with substance abuse is a challenge in itself, especially amidst the changes induced by the COVID-19 pandemic. Restrictions about people meeting together, shortage of health resources, healthcare staff burnout and communication obstacles as the obligation of mask wearing, all this add to the underestimation of the importance of group psychotherapy as part of inpatient treatment. Despite these barriers, we consider that inpatient group psychotherapy is more necessary than ever as inpatients suffer especially from isolation due to COVID-19 pandemic related measures.Therefore, it is essential to rethink a new way of inpatient group psychotherapy in times of COVID-19 pandemic.
Ultrafast Doppler imaging and Ultrasound Localization Microscopy reveal the complexity of vascular rearrangement in chronic spinal lesion
Authors: Pezet Sophie , Beliard Benoit , Ahmanna Chaimae , Tiran Elodie , Kanté Kadia , Deffieux Thomas , Tanter Mickael , Nothias Fatiha , Soares Sylvia
Published: November 2021

Acute spinal cord injury (SCI) leads to severe damage to the microvascular network. The process of spontaneous repair is accompanied by formation of new blood vessels; their functionality, however, presumably very important for functional recovery, has never been clearly established, as most studies so far used fixed tissues. Here, combining ultrafast Doppler imaging and Ultrasound Localization Microscopy (ULM) on the same animals, we proceeded at a detailed analysis of structural and functional vascular alterations associated with the establishment of chronic SCI, both at macroscopic and microscopic scales. Using a standardized animal model of SCI, our results demonstrate striking hemodynamic alterations in several subparts of the spinal cord: a reduced blood velocity in the lesion site, and an asymmetrical hypoperfusion caudal but not rostral to the lesion. In addition, the worsening of many evaluated parameters at later time points suggests that the neoformed vascular network is not yet fully operational, and reveals ULM as an efficient in vivo readout for spinal cord vascular alterations. Finally, we show statistical correlations between the diverse biomarkers of vascular dysfunction and SCI severity. The imaging modality developed here will allow evaluating recovery of vascular function over time in pre-clinical models of SCI. Also, used on SCI patients in combination with other quantitative markers of neural tissue damage, it may help classifying lesion severity and predict possible treatment outcomes in patients.
Decoding the olfactory map: targeted transcriptomics link olfactory receptors to glomeruli
Authors: Zhu Kevin , Burton Shawn , Nagai Maira , Silverman Justin , De March Claire , Wachowiak Matt , Matsunami Hiroaki
Published: November 2021

Sensory processing in olfactory systems is organized across olfactory bulb glomeruli, wherein axons of peripheral sensory neurons expressing the same olfactory receptor co-terminate to transmit receptor-specific activity to central neurons. Understanding how receptors map to glomeruli is therefore critical to understanding olfaction. High-throughput spatial transcriptomics is a rapidly advancing field, but low-abundance olfactory receptor expression within glomeruli has previously precluded high-throughput mapping of receptors to glomeruli. Here we combined sequential sectioning along the anteroposterior, dorsoventral, and mediolateral axes with target capture enrichment sequencing to overcome low-abundance target expression. This strategy allowed us to spatially map 86% of olfactory receptors across the olfactory bulb and uncover a relationship between OR sequence and glomerular position.
A Novel Insight Into Mechanism of Derangement of Coagulation Balance: Interactions of Quantum Dots with Coagulation-Related Proteins
Authors: Zhang Lingyan , Wu Yingting , Luo Xingling , Jia Tianjiang , Li Kexin , Zhou Lihong , Mao Zhen , Huang Peili
Published: November 2021

Background
Quantum dots (QDs) have gained increased attention for their extensive biomedical and electronic products applications. Due to the high priority of QDs in contacting the circulatory system, understanding the hemocompatibility of QDs is one of the most important aspects for their biosafety evaluation. Thus far, the effect of QDs on coagulation balance haven’t been fully understood, and limited studies also have yet elucidated the potential mechanism from the perspective of interaction of QDs with coagulation-related proteins.
Results
QDs induced the derangement of coagulation balance by prolonging the activated partial thromboplastin time and prothrombin time as well as changing the expression levels of coagulation and fibrinolytic factors. The contact of QDs with PTM (prothrombin), PLG (plasminogen) and FIB (fibrinogen) which are primary coagulation-related proteins in the coagulation and fibrinolytic systems formed QDs-protein conjugates through hydrogen-bonding and hydrophobic interaction. The affinity of proteins with QDs followed the order of PTM>PLG>FIB, and was larger with CdTe/ZnS QDs than CdTe QDs. Binding with QDs not only induced static fluorescence quenching of PTM, PLG and FIB, but also altered their conformational structures. The binding of QDs to the active sites of PTM, PLG and FIB may promote the activation of proteins, thus interfering the hemostasis and fibrinolysis processes.
Conclusions
The interactions of QDs with PTM, PLG and FIB may be key contributors for interference of coagulation balance, that is helpful to achieve a reliable and comprehensive evaluation on the potential biological influence of QDs from the molecular level.
Willingness to Pay for Assisted Reproductive Technologies by Pastoral Herd Owners in Southern Rangelands of Kenya
Authors: Agutu Fredrick Odiwuor , Ondiek James Ombiro , Mbuku Samuel Mwanzia , Bebe Bockline Omedo
Published: November 2021

Uptake of Assisted Reproductive Technologies (ARTs) can widen and accelerate access to quality breeding stock under pastoral systems, but user participation without subsidy is uncertain when the herders have to meet the direct cost. Analysing willingness to pay (WTP) for ARTs may provide insights into potential uptake of ARTs when development agencies withdraw subsidies and private entrepreneurs take up the service delivery. This study estimated WTP for ARTs among 130 pastoral herd owners participating in Sahiwal cattle breed upgrading program implemented in Transmara Sub County in the southern rangelands of Kenya. The average WTP was KES 3,643 (USD 33.4), equivalent to 21.4% premium with reference to base price (KES 3,000) (USD 27.5). Sixty-seven percent of the pastoral herd owners expressed WTP above the hypothesized market price, twice more than those expressing WTP below the hypothesized market price (33%). The first choice attributes influencing the WTP for ARTs were high milk yield (62%), high value calves (37%), and high growth rates (1%). Gender was the only socioeconomic factor significantly (P<0.005) influencing WTP, with men expressing higher WTP than women (KES 3,870 (USD 35.5) versus KES 3,223 (USD 26.6). The results indicate a high likelihood of pastoral herd owners continuing to access and use ARTs at own cost, which provides opportunities for private sector participation in ARTs delivery and upscaling to increase access to superior Sahiwal genetic resources in pastoral herds. This will need putting in place policy interventions supportive of efficient ARTs delivery mechanisms.
Effects of Transcutaneous Electrical Nerve Stimulation on Myocardial Protection in Patients Undergoing Aortic Valve Replacement: A Randomized Clinical Trial
Authors: Cho Youn Joung , Jung Dhong-Eun , Nam Karam , Bae Jinyoung , Lee Seohee , Jeon Yunseok
Published: November 2021

BackgroundTranscutaneous electrical nerve stimulation (TENS) has been found to have cardioprotective effects. However, its effects on adult cardiac surgery patients remain unclear. We investigated the effects of TENS on myocardial protection in patients undergoing aortic valve replacement surgery using cardiopulmonary bypass.MethodsThirty patients were randomized to receive TENS or sham in three different anesthetic states – pre-anesthesia, sevoflurane, or propofol (each n = 5). TENS was applied at the upper arm for 30 min. Sham treatment was provided without nerve stimulation. The primary outcome was the difference in myocardial infarct size following ischemia-reperfusion injury in rat hearts perfused with pre- and post-TENS dialysate from the patients using Langendorff perfusion system.ResultsThere were no differences in myocardial infarct size between pre- and post-treatment in any group (41.4 ± 4.3% vs. 36.7 ± 5.3%, 39.8 ± 7.3% vs. 27.8 ± 12.0%, and 41.6 ± 2.2% vs. 37.8 ± 7.6%; p = 0.080, 0.152, and 0.353 in the pre-anesthesia, sevoflurane, and propofol groups, respectively).ConclusionsTENS did not have a cardioprotective effect in patients undergoing aortic valve replacement surgery.Trial registrationThis study was registered at clinicaltrials.gov (NCT03859115, on March 1, 2019).
A Protocol for a Market of Machine Learning Models
Authors: Popescu Claudiu Marius
Published: November 2021

This paper describes a protocol for a market of machine learning models. The economic interaction involves two types of agents: data providers- agents that have some data and want to use it to get a predictive model, and model providers- agents able to use the data to generate predictive models. First, we will show that the process is informationally asymmetric, therefore a standard direct market can not function. Then, we design a protocol with the aim of creating a viable and efficient market mechanism for these particular services, under the specific challenges of information asymmetries. The protocol is theoretically analysed, to establish it’s correctness and computational complexity. We also propose a simple reference implementation based on a HTTP API. The implementation is then used in a few case studies, and analysed empirically.
Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from Hescs: Implications for Lung Fibrosis
Authors: Magro-Lopez Esmeralda , Chamorro-Herrero Irene , Zambrano Alberto
Published: November 2021

BackgroundIn our previous work, we evaluated the therapeutic effects of 1α,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in the context of bleomycin-induced lung fibrosis. Contrary to the expected, vitamin D supplementation increased DNA damage expression and cellular senescence in alveolar epithelial type II cells and aggravated the overall lung pathology induced in mice by bleomycin. These effects were probably due to an alteration of the cellular DNA double-strand breaks repair capability. In the present work we have evaluated the effects of two hypocalcemic vitamin D analogs (calcipotriol and paricalcitol) in the expression of DNA damage in the context of minilungs derived from human embryonic stem cells and in the cell line A549.ResultsAs in the case of the cell line A549, bleomycin can induce DNA damage in the generated minilungs enriched in alveolar cells. The results indicate that, in contrast to vitamin D, the treatment of the minilungs with the hypocalcemic analogs reduce significantly the bulk of DNA damage expression in both bidimensional arrays of epithelial cells (2D minilungs) and lung bud organoids (3D minilungs). The initial evaluation of a battery of commercially available vitamin D analogs shows a significant reduction in A549 cells of gH2AFX expression levels, a marker of DNA damage, cell senescence and aging.ConclusionsThe treatments based in hypocalcemic vitamin D analogs might be used to reduce the bulk of DNA damage and eventually the subsequent cell senescence expression that underlie lung conditions as those that can evolve with fibrosis.
Supply-Demand Matching of Medical Services in Haikou Under the Background of Hierarchical Diagnosis and Treatment - Based on Didi Travel Data
Authors: Shao Haiyan , Jin Cheng , Xu Jing , Zhong Yexi , Xu Bing
Published: November 2021

Background

Implementation of the Healthy China Strategy and the hierarchical diagnosis and treatment system has injected new vitality into medical services. Given the insufficient supply of medical services and increasing demand for medical treatment, exploring the supply-demand pattern of medical services has become an urgent theoretical and practical problem to be solved. The equity of healthcare facilities has received widespread attention, but due to limited data, there is little research on the supply-demand pattern of medical services. This study focuses on evaluating the supply-demand matching pattern of medical services at different levels in Haikou City with big geographic data and promoting the realization of a balance between medical supply and demand.
Methods

This study utilizes spatial data of medical institutions, didi travel data, and population density data. Firstly, use the two-step floating catchment area method and GIS spatial analysis to explore characteristics of the supply-demand patterns of medical services at different levels in Haikou. Secondly, based on didi travel data, mine residents' demand for medical treatment. Then combined with population density data, divide supply-demand matching of medical institutions into four types. Finally, propose optimization strategies for the problems.
Results

The accessibility pattern of high-level medical institutions in Haikou presents high in the north and low in the south. The accessibility pattern of low-level medical institutions is the opposite. High-level medical institutions have a strong need for medical treatment, which is less hampered by distance. The healthcare demand of low-level medical institutions is small, and they mainly are medium- and short-distance medical travel. The types of medical services at different levels are mainly "low supply - low demand" and "high supply - low demand" types.
Conclusions

Medical services at different levels in Haikou are mainly in supply-demand imbalance. Therefore, we put forward optimization strategies to promote the equity of primary medical services, such as propelling the establishment and improvement of the hierarchical diagnosis and treatment system, building a new model of medical and health service supply, and strengthening balanced coverage of primary medical institutions. The mining of big geographic data is beneficial to alleviate the contradiction between medical supply and demand, although the data and methods need to be improved.
Application of Multi-Attribute Decision-Making Methods for the Selection of Conveyor
Authors: Fulzele Satyam , Khatke Satywan , Kadam Shubham , Kamble Avinash
Published: November 2021

In the present time of innovation, conveyor assume an exceptionally indispensable part and have huge significance for material handling in different enterprises. A conveyor is essentially utilized for moving any sort of material from one area to other. It is made with nearer precisions, hence the expense related with manufacturing is additionally high. In this manner, it should work with better productivity. The choice of the best conveyor is a crucial activity for designers. Designers need to recognize different variables that will influence the functionalities of the conveyor system to limit bottlenecks in the system. An efficient methodology should be accomplished for the conveyor selection. Subsequently, the current work aims to the selection process of the best option for conveyor by using four decision making methods such as analytical hierarchy process, technique of order preference by similarity to ideal solution, compromise ranking method and Deng’s similarity based method. The selection is done among four alternatives based on six attributes viz: fixed cost each hour, variable cost each hour, conveyor speed, product width, product weight and flexibility. The analytical hierarchy process is used to determine weights of the attributes based on relative importance of each attribute. It is also observed that A3 conveyor is best suitable conveyor. Hence the above proposed strategies help decision-makers to examine and choose the best conveyor by considering the rank obtained of the alternatives.
The Role of Irinotecan-Bevacizumab as Rescue Regimen in Children With Low-Grade Gliomas: A Retrospective Nationwide Study in 72 Patients
Authors: de Marcellus Charles , Tauziède-Espariat Arnault , Cuinet Aurélie , Pasqualini Claudia , Robert Matthieu P. , Beccaria Kévin , Puget Stéphanie , Boddaert Nathalie , Figarella-Branger Dominique , De Carli Emilie , Bourdeaut Franck , Leblond Pierre , Fouyssac Fanny , Andre Nicolas , Bertozzi Anne I. , Butel Thibault , Dufour Christelle , Valteau-Couanet Dominique , Varlet Pascale , Grill Jacques
Published: November 2021

Introduction.
At least half of children with low-grade glioma (LGG) treated with first line chemotherapy experience a relapse/progression and may therefore need a second-line chemotherapy. Irinotecan-bevacizumab has been recommended in this setting in France after encouraging results of pilot studies. We performed a retrospective analysis to define the efficacy, toxicity and predictors for response to the combination on a larger cohort.
Methods.
We reviewed the files from children < 19 years of age with progressive or refractory LGG treated between 2009 and 2016 in 7 French centers with this combination.
Results.
72 patients (median age 7.8 years [range, 1-19]) received a median of 16 courses (range, 3-30). The median duration of treatment was 9 months (range, 1.4-16.2). 96% of patients experienced at least disease stabilization. The 6-month and 2-year progression-free survivals (PFS) were 91.7% [IC 95% 85.5-98.3] and 38.2% [IC 95% 28.2-51.8] respectively. No progression occurred after treatment in 18 patients with a median follow-up of 35.6 months (range, 7.6-75.9 months). Younger patients had a worse PFS (p=0.005). Prior chemoresistance, NF1 status, duration of treatment, histopathology or radiologic response did not predict response. The most frequent toxicities related to bevacizumab included grades 1-2 proteinuria in 21, epistaxis in 10, fatigue in 12 and hypertension in 8 while gastro-intestinal toxicity was the most frequent side effect related to irinotecan.
Conclusion.
Bevacizumab-irinotecan is highly effective for children with recurrent LGG who have failed standard chemotherapy regimens whatever their clinical characteristics, only younger children had a worse PFS.
WITHDRAWN: Effects of dietary energy and protein levels on growth curve parameters of Khazak native chickens
Authors: Faraji-Arough hadi , Ghazaghi Mahmoud , Kasmani Farzad Bagherzadeh , Rokouei Mohammad
Published: November 2021

This study was conducted to evaluate the effect of dietary energy (ME) and protein (CP) on growth parameters and absolute growth rates in the different ages of the Khazak chicks. A total of 360 one-day-old Khazak chicks were obtained from a local hatchery and in a 3×3 factorial experiment with completely randomized design, chicks were randomly allocated to experimental diets including 2,600, 2,800, and 3,000 kcal of ME/kg, and each containing 17, 19, and 21% CP from 7 to 98 days of age. Four growth model (Gompertz, Logistic, Lopez, and Richards) were fitted on weekly body weight data and the best model were selected by the goodness of fit criteria. Growth curve parameters were predicted for all chicks using the best model and other parameters including age (Ti) and weight (Wi) at the inflection point and absolute growth rate (AGR) in different ages were calculated from growth curve parameters. All parameters were analyzed using the general linear model procedure of SAS. Based on goodness of fit criteria, the Richards model had the lowest Akaike’s Information Criteria (AIC), root mean square error (RMSE), and highest adjusted determination coefficient (R2Adj) than other models and was selected as the best model. The effect of ME was significant on the mature index (k), Wi, Ti, and all AGR parameters (P<0.05) while CP levels were significant on final weight (Wf), Wi, and AGR parameters (P<0.05). The chicks fed with a diet containing 2,600 kcal of ME/kg and 17 % CP had the higher k parameter, and lower Wi, Ti, and AGR than those fed with other diets (P<0.05). Considering that the level of 2,800 kcal of ME/kg and 19 % CP had no significant difference with the level of 3,000 kcal of ME/kg and 21 % CP, therefore diet with 2,800 kcal of ME/kg and 19 % CP was suggested as optimum levels for change the growth curve parameter and having best performance for Khazak chickens during 7 to 98 days of old.
Massive Digital Gene Expression Analysis Reveals Different Predictive Profiles for Immune Checkpoint Inhibitor Therapy Between Adenocarcinoma and Squamous Cell Carcinoma of Advanced Lung Cancer
Authors: Kaneda Toshihiko , Kurata Takayasu , Yoshida Tomoko , Kibata Kayoko , Yoshioka Hiroshige , Yanagimoto Hiroaki , Takeda Kazuhiko , Yoshida Takao , Tsuta Koji
Published: November 2021

Background: Immune checkpoint inhibitors prolong the survival of non-small cell lung cancer (NSCLC) patients.Although it has been acknowledged that there is some correlation between the efficacy of anti-programmed cell death-1 (PD-1) antibody therapy and immunohistochemical analysis, this technique is not yet considered foolproof for predicting a favorable outcome of PD-1 antibody therapy. We aimed to predict the efficacy of nivolumab based on an exhaustive analysis of RNA expression at the gene level in advanced NSCLC.Methods: This was a retrospective study on patients with NSCLC who were administered nivolumab at the Kansai Medical University Hospital. To identify genes associated with response to anti-PD-1 antibodies, we grouped patients into responders (complete and partial response) and non-responders (stable and progressive disease) to nivolumab therapy. Significant genes were then identified for these groups using Welch’s t-test.Results: Among 42 analyzed cases (20 adenocarcinomas and 22 squamous cell carcinomas), enhanced expression of MAGE-A4,BBC3 and OTOA genes was observed in responders with adenocarcinoma, and enhanced expression of DAB2, HLA-DPB1and CDH2genes was observed in responders with squamous cell carcinoma.Conclusions: This study predicted the efficacy of nivolumab based on an exhaustive analysis of mRNA expression at the gene level in advanced NSCLC. We also revealed different gene expression patterns as predictors of the effectiveness ofanti PD-1 antibody therapy in adenocarcinoma and squamous cell carcinoma.
Quality of Life After Definitive Linear Accelerator-based Stereotactic Radiotherapy for Prostate Cancer: a Longitudinal Study
Authors: Yamashita Hideomi , Ogita Mami , Sawayanagi Subaru , Nozawa Yuki , Abe Osamu
Published: November 2021

Background: Prostate cancer is the second most common malignancy worldwide, and the majority of patients are diagnosed with localized disease. We examined patients’ quality of life after stereotactic body radiation therapy (SBRT) for prostate cancer. Method: We included patients who were treated between 2016 and 2020. Inclusion criteria were adenocarcinoma of the prostate; class risk of low, intermediate, and high; and a World Health Organization performance status of 0–2. Quality of life was measured using the Functional Assessment of Cancer Therapy-Prostate (FACT-P). Results: A total of 439 patients were treated with SBRT, with a median age of 73 years old. The median follow-up period was 34 months. FACT-P Trial Outcome Index (p < 0.0001), FACT-General (p = 0.0003), and FACT-P-Total (p < 0.0001) scores declined at 1 month post-SBRT, then recovered and returned to the same level as before treatment at 3–4 months post-SBRT. The decrease in quality of life in the first month was particularly remarkable in patients who received long-term hormone injections (36%). One month after the end of SBRT, about 22% of patients experienced "quite a bit” or more troubling side effects. Conclusions: This study showed longitudinal changes in quality of life by FACT-P after SBRT for prostate cancer. Overall, prostate SBRT was well tolerated.
Transcriptional Analysis and Target Genes Discovery of Pseudomonas Aeruginosa Biofilm Developed Ex Vivo Chronic Wound Model
Authors: Tan Xiaojuan , Cheng Xi , Hu Mei , Zhang Yifan , Jia Aiqun , Zhou Jinwei , Zhu Guoping
Published: November 2021

Bacterial biofilms formation is one of the major reasons for treatment failure in chronic wound infections. Therefore, diagnostic biomarkers remain the best option for prevention and treatment of chronic wound infections by biofilms. Herein, Pseudomonas aeruginosa PAO1 was used to mimic biofilm development in porcine skin explants wells as ex vivo wound model. The microscopic imaging showed that PAO1 in porcine skin explants wells formed micro-colonies at 24 h, developed mushroom-like structure at 48 h, and at 72 h mushroom-like structure disappeared, remaining a thin bacterial lawn. RNA-seq data analysis revealed that the expression levels of genes involved in the type II hxc secretion system were significantly higher in biofilms than in planktonic cells, especially the expression of lapA encoding alkaline phosphatase. However, the expression levels of genes associated with denitrification pathway were markedly decreased in biofilms, especially the transcription of nirS encoding nitrite reductase to produce nitric oxide (NO). Therefore, their expressions and products were further detected using RT-qPCR and biochemical assays, respectively. The results found that the expression of lapA and alkaline phosphatase activity were induced, but the expression of nirS and intracellular NO were reduced at the whole biofilms cycle. The study indicates that LapA and NO would play an important role for P. aeruginosa biofilm formation in chronic wound infections. LapA would serve as potential target to monitor chronic wound infections by P. aeruginosa biofilms. Inducing NO would be used to treat chronic wound infections due to P. aeruginosa biofilms.
Characterization the binding of cytosolic phospholipase A2 alpha and NOX2 NADPH oxidase in mouse macrophages
Authors: Solomonov Yulia , Hadad Nurit , Levy Rachel
Published: November 2021

Background: Previous studies have demonstrated that Cytosolic phospholipase A2a (cPLA2a) is absolutely required for NOX2 NADPH oxidase activation in human and mouse phagocytes. Moreover, upon stimulation, cPLA2a translocates to the plasma membranes of by binding to the assembled oxidase, forming a complex between its C2 domain and the PX domain of the oxidase cytosolic factor, p47phox in human phagocytes. Intravenous administration of an antisense against cPLA2a that significantly inhibited its expression in mouse peritoneal neutrophil and macrophages also inhibited superoxide production, in contrast to cPLA2a knockout mice that showed normal superoxide production. The aim of the present study was to determine whether there is a binding between cPLA2a-C2 domain and p47phox-PX in mouse macrophages, to further support the role of cPLA2a in oxidase regulation also in mouse phagocytes. Methods and Results: A significant binding of mouse GST-p47phox-PX domain fusion protein and cPLA2a in stimulated mouse phagocyte membranes was demonstrated by pull down experiments, although lower than that detected by human p47phox-PX domain. Substituting the amino acids Phe98, Asn99 and Gly100 to Cys98 Ser99 and Thr100 in mouse p47phox-PX domain (that are present in human p47phox-PX domain) caused strong binding that was similar to that detected by the human p47phox-PX domain. Conclusions: the binding between cPLA2a-C2 and p47phox-PX domains exist in mouse macrophages and is not unique to human phagocytes. The binding between the two proteins is lower in the mice probably due to the absence of amino acids Cys98 Ser99 and Thr100 in p47phox-PX domain that facilitate the binding to cPLA2a.
Comparison of Sexual Function in Fertile and Infertile Women with Polycystic Ovary Syndrome (PCOS): A Comparative Cross-Sectional Study
Authors: Azarbayjani Khadijeh , Sadatmahalleh Shahideh Jahanian , mirzaie Negin , Jahangiri Nadia , Nasiri malihe , Zeinaloo Mona
Published: November 2021

Background: Polycystic Ovarian Syndrome (PCOS) is a common hormonal disorder that affects approximately 5-20% of women of childbearing age. Physical and psychological changes caused by PCOS might impair women’s sexual function. Infertility is one of the most important complications that may be seen in women with PCOS. This study aimed to compare sexual function in fertile and infertile women with PCOS diagnosis.Method: This cross-sectional study was conducted on 364 fertile and 239 infertile women that diagnosed with PCOS according to the Rotterdam criteria from May 2018 to February 2019. All participants were asked to fill out included demographic survey and Female Sexual Function Index (FSFI) questionnaires.Result: The mean total FSFI score in fertile and infertile women was 23.70±6.26 and 24.65±4.04, respectively. With regard to FSFI, the differences between the two groups were not statistically significant in terms of total FSFI score, desire, lubrication, satisfaction, and arousal score (P>0.05). However, the pain score, was significantly higher in the fertile group. (3.51±1.27, 3.10±1.11, P<0.001). Conclusion: Impaired sexual function in infertile women diagnosed with PCOS can be more associated with PCOS-related complications and other concurrent factors that affects sexual function rather than infertility. It seems that the effects of infertility on sexual function can be different in infertile women according to each person's condition. Hence, screening for sexual dysfunction in women with PCOS and infertility should be deemed as a part of clinical assessment, leading to early diagnosing and improving their quality of life.