bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis keterampilan menyimak tayangan belajar di TVRI pada peserta didik kelas V sekolah dasar
Authors: Faizah Siti Nurul , Sukarno Sukarno , Sriyanto Muhammad Ismail
Published: March 2024

This study aims to describe the listening skills of grade V Mangkuyudan elementary school students in the 2020/2021 academic year through learning shows on TVRI. This research uses descriptive qualitative research methods with a case study approach. Primary data were obtained directly from grade V students and teachers at Mangkuyudan elementary school Surakarta, while secondary data was in the form of documents of student work, teacher notes, and official documents in writing at Mangkuyudan elementary school which had a relationship with the focus of the research problem. Sources of data in this study were students of class V which consisted of 28 students as the research sample. The data collection technique was done by using questionnaires, interviews, and study documentation. The data validity test technique used source triangulation and technique triangulation. The data analysis technique used qualitative data analysis by Miles and Huberman's model, namely interactive analysis. The results of this study indicate that the students' listening skills are good, as evidenced by the class average score that has met the minimum completeness criteria. With the details that the value on numeration, namely mathematics, is lower than the value of other subject matter. The implication of this research is to increase the creativity of teachers to determine variations in methods, strategies, and effective media in online learning during the pandemic
Analisis keterampilan guru dalam mengadakan variasi pada pembelajaran ips kelas iv sd
Authors: Tyas Pertiwi Dyah Musthikaning , Marmoah Sri , Hadiyah Hadiyah
Published: March 2024

This study aims to describe the teacher skills conducting variations in social studies learning. This research are descriptive qualitative. This research was conducted at SD Negeri Dukuhan Kerten No. 58. The subject of this research is 4th grade teacher. Data collection techniques used observation, interview, questionnaires and documentation. Data analysis techniques used data reduction, data presentation, and drawing conclusions. The results of research showed that the 4th grade teacher had implemented a variety of social studies learning well, but the variations in the use of learning media were still less visible. The variations made by the teacher were variations in teaching styles, variations in the use of learning media, and variations in student interactions and activities. The conclusion of research is the  teacher skills conducting variations in social studies learning are good.
Penerapan penilaian otentik dalam pembelajaran tema peduli terhadap makhluk hidup pada kelas IV sekolah dasar
Authors: Tiyas Annisa Puspitaning , Chumdari Chumdari , Karsono Karsono
Published: March 2024

The purpose of this research was to find out about the application of authentic assessment in the Ta'mirul Islam Surakarta Elementary School, and to determine the extent of the suitability between the applied authentic assessment and the Assessment Guidelines for Elementary Schools.This research is a descriptive qualitative research. The main subjects in this research were teachers of grade four H and the main object was an assessment document. Data collection techniques used were observation, interview, and document study techniques. Data validity in this research used data triangulation techniques. Analysis of the data used in this research is to use data analysis model of Miles and Huberman.The results of this research is The teacher applied three aspects of assessment. First, afektif aspect uses observation, self, and peer assessment techniques. Second, kognitif aspect uses written test assessment techniques, oral tests, and assignments. Third, psikomotor aspect uses performance and project assessment techniques. The conclusion of this research is that teachers have implemented an assessment of the 2013 Curriculum based on the Assessment Guidelines for Primary Schools published by the Ministry of Education and Culture, but not all of them have been implemented in practice.
Analisis kedisiplinan belajar ips tema indahnya kebersamaan secara daring selama pandemi covid-19 pada peserta didik kelas iv sekolah dasar
Authors: Rahayu Panggih , Sukarno Sukarno , Sriyanto Muhammad Ismail
Published: March 2024

The purpose of this research is to describe the discipline of learning social studies with the theme of the beauty of togetherness and the constraints of discipline in learning online during the COVID-19 pandemic for 4 grade students of elementary school. This study uses a descriptive qualitative research approach. The research design used is a type of case study field research. Sources of data in this study were students, parents, and class IV teachers at elementary school. Techniques for data collection in this study used questionnaires, interviews, and documentation studies. The data validity test was used source triangulation and technique triangulation. Data analysis of Miles and Huberman's model. Discipline in social studies with the theme of the beauty of togetherness shows moderate category results with indicators of discipline following online learning, discipline in doing assignments, discipline in studying at home, discipline in managing time at home. Discipline learning constraints, namely the constraints of implementing learning carried out at home instead of school and obstacles to learning online only have limited time. The results of the research can add to their treasures and as a reference for students' online learning discipline during the COVID-19 pandemic.
Analisis dampak kompetensi guru pada implementasi pendidikan karakter siswa kelas rendah selama pembelajaran daring di sekolah dasar
Authors: Wardani Sari Ilham , Mulyono Hadi , Adi Fadhil Purnama
Published: March 2024

The purpose of the research was to analyzed and described the impact of teacher’s competence as an attempt to implementation character building on low-grade student during online learning. This research study is qualitative descriptive with qualitative case study methods. The data and source data was collected from the low-grade teacher that consisted of teacher of class I, II and III SD Negeri Totosari. The data of the research obtained used data collection interview, observation and documentation. This research used triangulation technique as the validity data research. This study using analysis interactive data Miles and Huberman. Procedure of the research used case study methods by Cresswell. The result of the research indicated that the teacher’s competence has many impacts to implementation of the character-building on low-grade student during online learning, teacher with a good competence will able to organize how the student’s activity that favour to character building during online learning can work effectively but the teacher with a low competence was lacked on organized how the activity class to favour character building during online learning well. 
Implementasi pembelajaran tematik berbasis sistem dalam jaringan di kelas III sekolah dasar
Authors: Sari Lathifah Aulia , Chumdari Chumdari , Karsono Karsono
Published: March 2024

This research aims to describe implementation of system-based thematic learning, in terms of supporting and inhibiting factors, efforts to optimize supporting factors, and overcoming inhibiting factors. This research was conducted at thrid grade SDN Tunggulsari II Laweyan Surakarta. This  research used descriptive qualitative methods. The subjects of this research were teachers, students, and parents. Data collection techniques were observation, interviews, and document study. Implementation of online system-based thematic learning to regard condition of students and parents considerations. In implementation there are supporting factors are interest in learning, maximum parental assistance, availability of mobile phones, internet quota, and a stable network. While the inhibiting factors are lazy to learn, less maximal parental assistance, limited cellphone facilities, internet quota limited, and unstable network. Efforts to optimize the supporting factors are motivation and data collection on the distribution of internet quota assistance on a regular basis. Efforts to overcome inhibiting factors are teacher motivation and assistance, between parents and students, as well as the role of the community. This research is important for improve learning during the Covid-19 pandemic.
MAKSIMALISASI KEUNTUNGAN DENGAN KENDALA FAKTOR-FAKTOR PRODUKSI PADA KEDAI KOPI BNO
Authors: Putri Saskia Noverina Andika , Riana Fitria Dina , Aprilia Anisa
Published: March 2024

Kedai Kopi BNO is one of the coffee shop in Balikpapan City. However, in the last 3 months (February-April 2021) their income has decreased. It caused by the use of production factors that are less than optimal. The purpose of this study are to analyzed the maximum profit that can be obtained from the results of linear programming analysis, and also to analyzed the sensitivity to changes in variables from the results of linear programming analysis. This research was conducted in May 2021. Data processing is using Microsoft Excel Data Solver software. The result of linear programming analysis is that the maximum profit that can be obtained by Kedai Kopi BNO is Rp11,498,448.98 per month. Utilization of roasting coffee, mineral water, liquid sugar, and labor hours is optimal. Business actors can only change the value of profits and the amount of raw materials between the minimum and maximum limits so that the production activities could continue to run at the recommended optimum level.
FAKTOR-FAKTOR YANG MEMENGARUHI NILAI TUKAR PETANI DI 10 PROVINSI DENGAN PERAN SEKTOR PERTANIAN TERTINGGI 2010-2020
Authors: Mulyana Reynaldi Galuh , Istiqomah Istiqomah , Fauzi Pahrul
Published: March 2024

In terms of GDP, the agriculture sector is the second biggest driver of the expansion of the national economy in 2019–2020. Despite the agriculture sector's significant contribution, it cannot be claimed that farmers' conditions are prosperous. A method used to gauge the degree of farmer welfare is the Farmer Exchange Rate (FER). The study's objective is to examine how labor productivity, rice productivity, and output of rice affect FER in Indonesia's ten provinces with the largest sector contributions. One sort of data that is used with the panel data multiple regression analysis approach is called secondary data. The findings of this study clarify that, in ten Indonesian provinces that are the subject of research from 2010 to 2020, While rice yield and productivity do not significantly affect FER, labour productivity does. The findings of this study offer recommendations for additional measures that the government should implement to reduce production costs.
Analysis of Pancasila Learner Profile Values in Indonesian Language Learning Book Texts
Authors: Monica Syafitri
Published: March 2024

This research aims to analyze the value content of the Pancasila student profile in the Indonesian language textbook for the Merdeka curriculum for class X, Puskurbuk Kemendikbudristek edition. The research method used is a qualitative descriptive method with content analysis. The research results, researchers found that the values ​​of the Pancasila student profile are found in introductory texts in books such as: 1) faith, devotion to God Almighty and noble morals, 2) critical thinking, 3) global diversity, 4) creativity , 5) mutual cooperation, and 6) independence. The value of each of these things is explained in various texts, including saga texts, anecdote texts, biographical texts and poetry texts. Learning activities carried out in the Merdeka Curriculum Indonesian Language Textbook for class X students will help students understand these values ​​and apply them in everyday life. This study provides a detailed and complete explanation of the contents of the profile of students' Pancasila values ​​in the texts contained in the book, so that it will help students improve their understanding and application of these values.
Teaching Higher Education Music Students How to Work with Orchestral and Ensemble Scores
Authors: Khodjayev Khushnudbek Abidinovich
Published: March 2024

This study outlines a pedagogical approach aimed at enhancing the proficiency of higher education music students in analyzing and interpreting orchestral and ensemble scores. The primary goals were to cultivate advanced score-reading skills and foster a nuanced understanding of orchestration techniques. Employing a systematic teaching methodology, incorporating theoretical frameworks and practical exercises, yielded noteworthy results. Students demonstrated significant improvements in score comprehension, ensemble coordination, and interpretive depth. The implications of this research extend beyond the classroom, offering a transformative model for music education that empowers students to engage with complex scores with precision and artistry. Highlights: Enhanced Score-Reading Skills: The methodology focuses on cultivating advanced proficiency in reading and interpreting complex orchestral and ensemble scores. Systematic Teaching Framework: A structured approach, combining theoretical foundations and practical exercises, is employed to facilitate comprehensive learning and application. Transformative Music Education Model: The research offers a pioneering model with implications beyond the classroom, empowering students to engage with intricate scores with precision and artistic depth. Keywords: Music Education, Orchestral Scores, Ensemble Coordination, Music Methodology, Music Literacy
Legal Protection for Buyers in a Junk Sale and Purchase Agreement
Authors: Afrizal Afrizal , Purwaningsih Sri Budi
Published: March 2024

This study aims to find out and examine the legal protection for buyers of junk goods, which focuses on the validity of the sale and purchase agreement of junk goods, as well as forms of preventive legal protection that can be carried out by junk collectors who are accused of being collectors. or the general public can defend themselves when they accidentally receive the proceeds of crime. This study uses a normative juridical method, with a statutory approach. The data comes from two main sources, namely the legal code and the criminal law code as primary legal materials and journals, books, doctrines as secondary legal materials. Using deductive analysis method. The conclusion of this study is that the sale and purchase agreement for junk goods is valid, when there is no violation of Article 1320 and Article 1457 of the Civil Code. As well as preventive legal protection efforts when accused of being a collector, such as a statement that the goods are junk from legal matters, transactions are carried out during the day, prices are according to the market and so on.
The Pancasila in the Age of Digital Society 5.0: Indonesia Legal System Perspective
Authors: Desinta Desinta Dwi Rapita
Published: March 2024

his study explores the transformative impact of the digital era, specifically Society 5.0, on the Indonesian legal system, focusing on the incorporation of Pancasila values as a universal ethical foundation. Adopting a normative legal research method with a conceptual approach, the study analyzes how the Indonesian legal system, predominantly influenced by the civil law system, adapts to the challenges posed by technological advancements and the emerging digital society. The research reveals that Indonesia's unique legal system, grounded in Pancasila, exhibits characteristics of religiosity, humanism, and social justice, enabling it to adapt to societal changes while maintaining core national values. The digital transformation, embodied in Society 5.0, necessitates a legal framework that balances economic development with social problem-solving through innovative and sustainable technology integration. The study highlights the increasing significance of cybersecurity awareness and the potential recognition of artificial intelligence as a new legal subject. Emphasizing the role of Pancasila's ethical principles, the study concludes that a consistent application of these values is crucial for developing a responsive legal system capable of addressing the complexities of a digital society. This alignment ensures that legal evolution aligns with societal aspirations, maintaining harmony and order within the framework of a rapidly evolving digital landscape. The findings underscore the importance of legal reform in legislative, human resources, institutional, and cultural aspects, advocating for a harmonized approach between technological advancements and existing or forthcoming regulations, guided by Pancasila's values.Highlights:

 

Pancasila as Ethical Guide: Emphasizes Pancasila's pivotal role in shaping Indonesia's legal responses to digital challenges.

Legal System's Digital Adaptation: Highlights the Indonesian legal system's evolution in the face of advancing digital technologies.

Harmonized Legal Reforms: Stresses the need for sustainable legal reforms aligned with societal values in the digital era.

Keywords: Society 5.0, Pancasila, Indonesian Legal System, Digital Transformation, Cybersecurity
Perception of E-Budgeting Implementation
Authors: Zulfiani Alfi Eka , Biduri Sarwenda
Published: March 2024

This study aims to determine the influence of system quality, information quality and quality of human resources on the implementation of e-budgeting in Sidoarjo Regency. This study uses a quantitative method with a questionnaire as a research instrument. The sample used was 10 OPD in Sidoarjo Regency. The sampling technique in this study used purposive sampling. The data analysis technique used is validity test, reliability test and classic assumption test while the hypothesis testing in this study uses multiple linear regression analysis. The results of the research obtained based on the validity test and reliability test showed that all questions were declared valid and reliable. The results of the analysis show that the quality of the system partially influences the implementation of e-budgeting. The quality of human resources partially influences the implementation of e- budgeting. While the quality of information does not partially affect the implementation of e-budgeting.
The Relationship Between Dysmenorrhea Pain And Academic Flow Of Psychology Study Program Students At Muhammadiyah University Of Sidoarjo For The 2022 – 2023 Academic Year
Authors: Pratiwi Mergy Rochmi , Dwi Nastiti
Published: March 2024

Penelitian ini dilatar belakangi karena ditemukan fenomena flow akademik yang rendah diantaranya sulit berkonsentrasi, tidak dapat beraktivitas dengan normal, merasa tidak nyaman dengan kondisi fisik, kurang tertarik dengan aktivitas yang dijalaninya saat mengalami menstruasi. Penelitian ini bertujuan untuk mengetahui hubungan antara nyeri dysmenorrhea dengan flow akademik mahasisiwi prodi psikologi univeritas muhammadiyah sidoarjo. Penelitian ini variabel yang terdapat adalah nyeri dysmenorrhea sebagai variabel bebas dan flow akademik sebagai variabel tergantung. Penelitian ini menggunakan metode kuantitatif korelasional, Populasi dalam penelitian ini sebanyak 447 mahasiswi prodi psikologi dan penentuan sampelnya dengan menggunakan teknik non random sampling dan sampel yang digunakan sebanyak 170 mahasiswi yang pernah mengalami nyeri saat menstruasi. Alat ukur yang digunakan untuk mengumpulkan data menggunakan skala nyeri dysmenorrhea dan skala flow akademik. Analisis data hasil penelitian yang dilakukan menggunakan perhitungan statistik korelasi pearson untuk mengetahui hubungan antara variabel nyeri dysmenorrhea dengan variabel flow akademik dengan bantuan program SPSS versi 24 for windows. Hasil dari penelian ini menunjukan koefisien korelasi product moment sebesar -0,096 dengan nilai signifikansi 0,000 < (0,05). Hal ini menunjukan bahwa hipotesis yang diajukan diterima, yaitu ada hubungan negatif antara nyeri dysmenorrhea dengan flow akademik. Artinya semakin tinggi nyeri dysmenorrhea maka semakin rendah flow akademik yang dialami mahasiswi, sebaliknya jika semakin rendah nyeri dysmenorrhea yang dialami mahasiswi maka semakin tinggi flow akademik mahasiswi. Nilai sumbagan efektif pengaruh nyeri dysmenorrhea terhadap flow akademik memperoleh hasil sebesar 1,1%.
Environmental DNA sampling for at-risk and invasive species management on military ranges : guidelines and protocols for installation biologists and land managers
Authors: Katz Aron , Johnson Mark , Sperry Jinelle
Published: March 2024

Environmental DNA (eDNA) analysis, or the detection of trace DNA shed by organisms into their environment, has the potential to transform Army capabilities for threatened and endangered species (TES) and invasive species management by providing a rapid, noninvasive, and cost-effective option for monitoring wildlife. Despite these benefits, eDNA analysis is underutilized on military installations as limited access to guidance materials, protocols, training opportunities, and support from eDNA scientists makes it difficult for installation biologists and military land managers to design and execute eDNA surveys, let alone identify management questions that may benefit from eDNA monitoring. Therefore, the aim of this resource is to increase awareness of the benefits and limitations of eDNA monitoring and provide eDNA study design guidelines and field sampling protocols for nonexperts to make this tool more accessible to installation biologists and land managers and help facilitate the adoption of eDNA-based approaches for wildlife management on military ranges.
Efficient Rare Event Sampling with Unsupervised Normalising Flows
Authors: Ni Ran , Asghar Solomon , Pei Qing-Xiang , Volpe Giorgio
Published: March 2024

From Physics and Biology to Seismology and Economics, the behaviour of countless systems is determined by impactful yet unlikely transitions between metastable states known as rare events, the study of which is essential for understanding and controlling these systems’ properties. Classical computational methods to sample rare events remain prohibitively inefficient and are bottlenecks for enhanced samplers requiring prior data. Here, we introduce a novel physics-informed machine learning framework, FlowRES, that uses unsupervised normalising flow neural networks to enhance Monte Carlo sampling of rare events by generating high-quality nonlocal Monte Carlo proposals. We validate FlowRES by sampling the transition path ensembles of equilibrium and non-equilibrium systems of Brownian particles exploring increasingly complex potentials. Beyond eliminating requirements for prior data, FlowRES features key advantages over established samplers: no collective variables need defining, efficiency remains constant even as events become increasingly rare, and systems with multiple routes between states can be straightforwardly simulated.
Electronic and magnetic excitations in La3Ni2O7
Authors: Zhou Ke-Jin , Chen Xiaoyang , Choi Jaewon , Jiang Zhicheng , Mei Jiong , Jiang Kun , Li Jie , Agrestini S. , Garcia-Fernandez Mirian , Sun Hualei , Huang Xing , Shen Dawei , Wang Meng , Hu Jiangping , Lu Yi , Feng Donglai
Published: March 2024

The striking discovery of high-temperature superconductivity (HTSC) of 80 K in a bilayer nickelate La3Ni2O7 under a moderately high pressure of about 14 GPa ignited a new wave of studying HTSC in nickelates. The properties of the parental phase at ambient pressure may contain key information on basic interactions therein and bosons that may mediate pairing giving birth to superconductivity. Moreover, the bilayer structure of La3Ni2O7 may suggest a distinct minimal model in comparison to cuprate superconductors. Here using X-ray absorption spectroscopy and resonant inelastic X-ray scattering, we studied La3Ni2O7 at ambient pressure, and found that Ni 3dx2y2, Ni 3dz2, and ligand oxygen 2p orbitals dominate the low-energy physics with a small charge-transfer energy. Remarkably, well-defined optical-like magnetic excitations were found to soften into a quasi-static spin-density-wave ordering, evidencing the strong electronic correlations and rich magnetic properties. Based on a Heisenberg spin model, we found that the inter-layer effective magnetic superexchange interaction is much larger than the intra-layer ones, and proposed viable magnetic structures. Our results highlight that the strong bonding of Ni 3dz2 orbitals within the bilayer structure induces novel electronic and magnetic excitations setting the stage for further exploration of La3Ni2O7 superconductor.
Increased free water in the nucleus basalis of Meynert is associated with worse olfaction in Parkinson’s disease
Authors: Wang Chao , Wang Shuyue , Zhou Cheng , Wu Chengqin , Zhang Minming , Huang Peiyu
Published: March 2024

The association of cholinergic basal forebrain (cBF) degeneration and olfactory function in Parkinson’s disease (PD) is unclear. We analyzed free water (FW) values in the cBF of participants from the PPMI dataset, and found increased FW values in the nucleus basalis of Meynert (NBM) were correlated with worse olfaction in patients with PD. FW in the NBM has the potential to provide early biomarkers of olfaction dysfunction in patients with PD.
Initial response to the 2024 Noto earthquake by the university hospital closest to the disaster area
Authors: Uramoto Hidetaka , Shimasaki Takeo , Sasaki Hiroshi , Iinuma Yoshitsugu , Kawasaki Yasuhiro , Kawahara Norio
Published: March 2024

Major earthquakes have occurred frequently in Japan throughout the course of history, and the 2024 Noto earthquake was no exception. However, such natural disasters do differ in some respects, and specific problems related to these events have also become clear. Our hospital, which was the closest university hospital to the disaster area of the 2024 Noto earthquake, is playing a crucial role in serving the local community in the wake of the earthquake. The first method used to identify disaster-related patients was to tag them when they were examined by a physician. After confirming that a patient was eligible at the disaster-related patient-determination meeting, the patients’ medical information was extracted from the tag name. A total of 421 disaster-related patients were transported and hospitalized by day 31. Fifty-two (14.4%) and 48 (13.3%) patients were admitted for orthopedic surgery and respiratory medicine, respectively. Forty (11.1%) and 38 (10.5%) patients were admitted to the cardiology and nephrology departments, respectively. These four departments accounted for 49.3% of the total. The number of hospitalized patients in the nephrology and orthopedic surgery departments was high immediately after the earthquake. We also describe new hospital-specific initiatives and recommendations to improve our hospital's system while sharing our hospital experience.
Scalable Glassy X-Ray Scintillators with Bright Singlet-Triplet Hybrid Self-Trapping Excitons
Authors: Liu Kai-Kai , Song Shi-Yu , Gao Chao-Jun , Zhou Rui , Wang Bingzhe , Zhao Wen-Bo , Cao Qing , Hu Yan-Wei , Dong Lin , Shan Chong-Xin
Published: March 2024

Size-scalable X-ray scintillators with high transparency and robust photon yield allow for imaging large objects with greater precision and detail. Solution-processable scintillators, typically crafted from quantum dots (QDs), are promising candidates for highly efficient scintillation applications. However, the restricted size, low transparency, and dark nature of triplet excitons in QD-based scintillators lead to less efficient X-ray imaging for large objects requiring high resolution. Herein, we demonstrate a meter-scale glassy ZnO QD scintillator with a visible range transmittance exceeding 96% at a thickness of 0.5 mm, showcasing bright singlet/triplet hybrid self-trapping hybrid excitons (STEs). The quantum yields (QYs) of singlet excitons and triplet excitons are 44.7% and 26.3%. Benefiting from a large Stokes shift and bright triplet excitons, the scintillator has a negligible self-absorption and elevated photon yields. Additionally, the scintillator exhibits exchange invariance, demonstrating identical optical performance upon exchanging the coordinates (r) of the QDs. Featuring bright singlet/triplet hybrid STEs and high transparency, the scintillator achieves high resolution X-ray imaging of 42 line pairs per millimeter (42 lp mm-1) at a meter scale. Moreover, demonstrations of 5000 cm2 X-ray imaging and real-time dynamic X-ray imaging are presented. The lowest detectable dose rate for X-ray detection is as low as 38.4 nGy s−1. This work provides a novel sizable and transparent scintillator with bright singlet/triplet hybrid excitons, showcasing their potential in high-resolution and sizable object X-ray imaging.
Ceramic Soft Tissue Trimming Bur Gingival Depigmentation: Clinical Performance and Patient Experience. “A Split Mouth Randomized Controlled Trial”
Authors: Nassar Sally Khaled , El-Ela Hala Ahmed Abu , Fouad Yasmine Ahmed
Published: March 2024

Background
Ceramic soft tissue trimming bur (Cerabur) was primarily launched to be used in gingivoplasty but has been used recently in gingival depigmentation. This study aimed to compare the efficacy of depigmentation using the novel cerabur versus the gold-standard surgical scalpel technique.
Methods
Eight healthy, non-smokers with moderate to severe gingival hyperpigmentation in both arches were randomly assigned for cerabur depigmentation in one arch as a test group (TG) and scalpel depigmentation in the opposite arch as a control group (CG). Pigmentation indices were used to assess the clinical outcome. Treatment time, pain levels, and esthetic satisfaction were the parameters of patient experience. The assessment was done at baseline, 1 week, 1 month, and 3 months.
Results
At all the assessment visits, the pigmentation intensity represented by Dummet oral pigmentation index (DOPI), and distribution represented by Hedin melanin index (MI) were significantly less than baseline (p < 0.001) in both groups. When comparing both groups, Scalpel depigmentation had better initial clinical outcomes, while Cerabur had less visible re-pigmentation, pain Scores, and treatment time, along with more esthetic satisfaction. However, all these differences were not statistically significant.
Conclusion
Both techniques successfully removed the gingival hyperpigmentation with comparable clinical outcomes. Cerabur depigmentation was favored by the patients.
Trial registration:
The study protocol was registered on 11/09/2023 on the www.clinicaltrials.gov database (NCT06031116) after the approval of the Ethics Committee, Faculty of Dentistry, Ain Shams University (FDASU-Rec012124).
Comprehensive Exploration of Technological Tensioning Effects in Welded Thin Plate Girders: An In-Depth Investigation
Authors: Khalaf Hassanein I. , Chodorowska D. , Al-Sabur Raheem , Kubit Andrzej , Macek Wojciech
Published: March 2024

Thin-walled plate girders occupy a special place in structures and construction due to their efficiency in carrying loads. The permanent deformations of the girder lead to a lack of stability, which necessarily leads to its replacement. Replacing permanently deformed thin-walled load-bearing structures requires large financial outlays. Technological prestressing is one of the most effective methods for studying and treating permanent deflections in girder elements. This study looks at the defection of welded thin-plate S235JR steel girders, examining how technological tensioning effects interact with different loading conditions. Four configurations were investigated: welded in bottom caps, welded in two side caps (two configurations), and welded in two side caps and bottom caps. Five loads of P (20, 40, 60, 80, and 95) kN were applied to the seven sensor positions of each girder section (A, B, C, and D). All points were examined during the 95 minutes of cooling time. For technological compression, the results showed that there is a convergence between the analytical solution and the experimental results, as the most significant deviation achieved in the analysis was 5.21 mm compared to 6 mm experimentally. When the grinder is loaded with the force P = 50N, the maximum defect achieved at grinder A4 is 4 mm, compared with 1mm at grinder A2. In prestressed grinder B, the deflections that were reached were 2.50 mm, 3.50 mm, and 3.52 mm in the analytical, experimental, and FE numerical models, respectively. The tensions that were reached were 36.96 MPa, 44.28 MPa, and 27.93 MPa.
A randomized proof-of-mechanism trial of TNF antagonism for motivational anhedonia and related corticostriatal circuitry in depressed patients with high inflammation
Authors: Treadway Michael , Etuk Sarah , Cooper Jessica , Hossein Shabnam , Hahn Emma , Betters Samantha , Liu Shiyin , Arulpragasam Amanda , DeVries Brittany , Irfan Nadia , Nuutinen Makiah , Wommack Evanthia , Woolwine Bobbi , Bekhbat Mandakh , Kragel Philip , Felger Jennifer , Haroon Ebrahim , Miller Andrew
Published: March 2024

Chronic, low-grade inflammation has been associated with motivational deficits in patients with major depression (MD). In turn, impaired motivation has been linked to poor quality of life across psychiatric disorders. We thus determined effects of the anti-inflammatory drug infliximab–a potent tumor necrosis factor (TNF) antagonist–on behavioral and neural measures of motivation in 42 medically stable, unmedicated MD patients with a C-reactive protein > 3mg/L. All patients underwent a double-blind, placebo-controlled, single-dose, randomized clinical trial with infliximab (5mg/kg) versus placebo. Behavioral performance on an effort-based decision-making task, self-report questionnaires, and neural responses during event-related functional magnetic resonance imaging were assessed at baseline and 2 weeks following infusion. We found that relative to placebo, patients receiving infliximab were more willing to expend effort for rewards. Moreover, increase in effortful choices was associated with reduced TNF signaling as indexed by decreased soluble TNF receptor type 2 (sTNFR2). Changes in effort-based decision-making and sTNFR2 were also associated with changes in task-related activity in a network of brain areas, including dmPFC, ventral striatum, and putamen, as well as the functional connectivity between these regions. Changes in sTNFR2 also mediated the relationships between drug condition and behavioral and neuroimaging measures. Finally, changes in self-reported anhedonia symptoms and effort-discounting behavior were associated with greater responses of an independently validated whole-brain predictive model (aka “neural signature”) sensitive to monetary rewards. Taken together, these data support the use of anti-inflammatory treatment to improve effort-based decision-making and associated brain circuitry in depressed patients with high inflammation.
High-Throughput profiling of SH2 domains using Affimer reagents: unravelling protein interaction networks
Authors: Heseltine Sophie J. , Billenness Gregory J. , Martin Heather L , Tiede Christian , Tang Anna A.S. , Foy Eleanor , Reddy Grace , Gibson Naomi , Webb Michael E. , McPherson Michael J. , Tomlinson Darren C. , Johnson Matt
Published: March 2024

Despite SH2 domains, being pivotal in protein interactions linked to various diseases like cancer, we lack specific research tools for intracellular assays. Understanding SH2-mediated interactions and creating effective inhibitors requires tools which target individual protein domains. Affimer reagents exhibit promise, yet their potential against the extensive SH2 domain family remains largely unexplored. Our study aimed to bridge this gap by identifying Affimer reagents that selectively bind to 22 out of 41 SH2 domains. These reagents enabled a medium-throughput screening approach resembling siRNA studies, shedding light on their functionality. Notably, select Affimers demonstrated the ability to curtail the nuclear translocation of pERK, with Grb2 being a prominent target. Further analyses revealed that these Grb2-specific Affimer reagents displayed competitive inhibition with impressive metrics: IC50s ranging from 270.9 nM to 1.22 µM, together with low nanomolar binding affinities. Moreover, they exhibited the ability to pull down endogenous Grb2 from cell lysates, illustrating their efficacy in binding the Grb2 SH2 domain. This comprehensive assessment underscores the potential of Affimer reagents as domain-specific inhibitors. Their viability for medium/high-throughput phenotypic screening presents a promising avenue via which to identify and characterize potential drug targets within the SH2 domain family.
TOO-BERT: A Trajectory Order Objective BERT for self-supervised representation learning of temporal healthcare data
Authors: Amirahmadi Ali , Etminani Farzaneh , Bjork Jonas , Melander Olle , Ohlsson Mattias
Published: March 2024

Healthcare data accumulation over time, particularly in Electronic Health Records (EHRs), plays a pivotal role by offering a vast repository of patient data with the potential to enhance patient care and predict health outcomes. While Bert-inspired models have shown promises in modeling EHR trajectories, the challenge lies in capturing intricate disease-intervention relationships over time. This study introduces TOO-BERT, enhancing MLM representations by explicitly leveraging sequential patient trajectory information at code and visit levels. TOO-BERT excels in learning frequent sequential patterns by refining the TOO self-supervised objective through two proposed methods, Conditional Code Swapping (CCS) and Conditional Visit Swapping (CVS) weighting functions. Evaluation on MIMIC-IV and Malmö Diet cohort datasets demonstrates TOO-BERT's performance in predicting Heart Failure (HF), Alzheimer's disease (AD), and Prolonged Length of Stay (PLS). Notably, TOO-BERT outperforms Bert in HF prediction, even with limited fine-tuning data. Our findings illustrate the potency of integrating TOO objectives in MLM-based models, enabling intricate EHR data relationships to be captured. Attention analysis highlights the model's capability to learn complex structural patterns.
Association between End-stage renal disease and the polymorphism of HLA in Guangxi Zhuang population
Authors: Pei Yongfeng , Li Haibin , Huang Chengxin , Qin Yinhong , Sun Xuyong
Published: March 2024

Objective: To investigate the genetic relationship between end-stage renal disease (ESRD) and the Guangxi Zhuang population's human leukocyte antigen (HLA) allele.
Methods: To perform the polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO)method, genotyping for 325 patients with ESRD at the HLA-A, B, C, DRB1, and DQB1 loci was done. The direct counting method was used to determine the HLA alleles' frequencies, and Arlequin software(3.5.2.2) was used for haplotypic frequency analyses, compared with 350 healthy donors of Guangxi Zhuang nationality.
Results: We found that only HLA-DRB1*14:54 showed a positive association with ESRD (P=0.005, Pc=0.035, OR=1.484, CI=1.122-1.963) after Bonferroni correction, so that it may be a protective allele for ESRD. A*11:01-B*15:02-DRB1*15:01 and A*11:01-C*08:01-B*15:02-DRB1*12:02-DQB1*03:01 were more prevalent in ESRD after Bonferroni correction.
Conclusion: ESRD patients and the healthy population in Guangxi Zhuang have high HLA-A, B, C, DRB1, and DQB1 allele and haplotype frequencies. DRB1*14:54, A*11:01-B*15:02-DRB1*15:01, and A*11:01-C*08:01-B*15:02-DRB1*12:02-DQB1*03:01 were potentially valuable allele and haplotypes for evaluating the risk of ESRD in Guangxi Zhuang population.
Dyadic Coping Experience With Pancreatic Cancer: a Qualitative Study of Dyadic Interviews
Authors: Zhang Bo , Xiao Qigui , Gu Jingtao , Ma Qingyong , Han Liang
Published: March 2024

Objective: Cancer affects the patients as well as their spouses. Couples use different strategies to cope with cancer and the associated burden. This qualitative dyadic interviews aims to gain a deeper and more differentiated understanding of the support system about couples.
Methods: An exploratory qualitative study set in China. The study was based on 10 pancreatic cancer couples semi-structured face-to-face interviews with patients undergoing pancreatic cancer and experiencing different symptoms. Interviews were verbatim transcribed and analysed using thematic framework analysis. This study was guided by the Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist.
Results: Ten pancreatic cancer couples (patients: seven men and three women) with different ages (patients: range = 49-75; spouses: range = 47-73), different stage of cancer (e.g., potentially resectable, borderline resectable, locally advanced) and cancer types (initial diagnosis or relapse) participated in the study. Eleven minor themes emerged from the data, namely unbearable pain, suffer from malnutrition,unhealthy eating habits, negative emotions, disease stigma, lack of knowledge, unable to fulfill social roles, forced to stop work, worried about a costly medical bill, conceal the fact about illness, and loss of intimacy with friends and spouse. All couples described cohesion in relationship as an essential common dyadic coping strategy. Most strategies were focused on the patient’s well-being. Furthermore, couples reported different common plans for the future: while some wanted to return to normality, others were reaching out for new goals.
Conclusions: Active dyadic coping is conducive to promoting disease adaptation, spouses seemed to need more psychological support to improve their own well-being particularly. Health care systems should pay attention to patients and spouses with pancreatic cancer in terms of the four areas of the RAM: physiological, self-concept, role function and interdependence. Future studies should use a combination of qualitative and quantitative methods to explain dyadic coping in greater depth.
Investigating ethical considerations in the communication network of married women undergone hysterectomy: Instrumentation of a questionnaire
Authors: Bahador Elahe , Tajadiny Laleh , Nataj Abolfazl Hossein , Ghazanfarpour Masumeh , Ahmadi Atefeh , Khorasani Fahimeh , Mobasher Mina , Tajadini Jaleh
Published: March 2024

Introduction: Considering the importance of complying medical and general ethics and the lack of a study on determining ethical considerations in the communication network of women undergoing hysterectomy surgery, this study aimed to present these aspects in the patients' lives by a standard researcher-made instrument. Method: This mixed method analysis (exploratory sequential mixed methods design was conducted in the whole of 2020 to create the “ethical considerations in communication network of women undergone hysterectomy” questionnaire and investigate its psychometric properties. A researched-made instrument was validated and its psychometric properties were checked among 218 women by confirmatory factor analysis (CFA). Results: Accordingly, the 8 factors extracted included “complying ethical consideration by the physician (a)”, “complying ethical consideration by medical team (b)”, “complying ethical consideration in the hospital (c)”, “complying ethical consideration by the secretory in the clinic (d)”, “complying ethical consideration by the spouse (e)”, and “complying ethical consideration by the family and friends (f)”, “complying ethical consideration by the media and society (g)” and “complying ethical consideration by herself (h)”. The results of Cronbach's alpha test showed that there is moderate to good internal consistency in all dimensions. Cronbach's alpha for the whole questionnaire was calculated as 0.75, which shows that the internal consistency is at a good level. Conclusion: According to the results of this study, the reliability (internal consistency) and construct validity of the ethical considerations in the communication network of women undergoing hysterectomy questionnaire were confirmed. However, in light of the study limitations, caution should be practiced in the interpretation of the results. There is a need for further longitudinal studies in multiple settings using random sampling methods.
Development and Implementation of a Transgender Medicine Curriculum for Internal Medicine residents
Authors: Sandre Anthony R. , Sidhu Bikrampal , Awad Sara
Published: March 2024

Background: Two-spirit, lesbian, gay, bisexual, transgender, queer, intersex, and asexual (2SLGBTQIA+) individuals present with unique health care needs and are known to have higher rates of chronic disease and substance misuse disorders. Further, patients who identify as transgender or gender non-conforming present with explicit health care needs as it relates to addressing gender dysphoria, psychosocial support, and medication access. Considering this, medical education strategies should be implemented to train the next generation of Internal Medicine physicians to be competent in this area.
Methods: We adopted Kern’s six step approach to curriculum design to create and implement an educational curriculum for teaching Internal Medicine residents the necessary skills to care for transgender patients (1). Semi-structured individual interviews of Internal Medicine Faculty and Residents were conducted to understand the needs for delivering content related to transgender health during residency training. The results informed the development and implementation of an academic half day (AHD) session and objective structured clinical examination (OSCE). Prior to the AHD, participants were sent three journal articles highlighting key concepts related to the medical care of transgender patients (2–4). A numeric assessment form was distributed to participants before and after the AHD which provided subjective assessment of comfort providing gender-affirming care.
Results: There was a significant increase in subjective comfort providing gender-affirming care (p = 0.042) following delivery of the AHD content. During the OSCE station, formal grading was conducted across five educational domains of transgender health. Most residents scored “acceptable” or “exemplary” on a global assessment scale by faculty raters. Both the clinical case and OSCE scenario were developed via an iterative review process by study investigators.
Conclusions: We implemented a novel Transgender Medicine curriculum for Internal Medicine residents. Following completion of the curriculum, residents have demonstrated competency in communication skills, basic knowledge on gender-affirming hormone therapy, and health promotion activities (e.g., screening for and management of chronic disease, discussion of sexual health, community supports, peer engagement).
Navigating the complexities of diabetes insipidus worsened by primary polydipsia: A case report
Authors: Davoudi Zahra , farsad faraneh , haghighimorad maryam , Ghaemi Farahnaz , Amirdosara Mahdi
Published: March 2024

Background: Fluid-electrolyte balance is regulated within a narrow range in diabetes insipidus. Coexisting Polydipsia and the related phenomenon of hyponatremia cause considerable mortality and morbidity.
Case presentation: this case report presents the detailed treatment of central diabetes insipidus aggravated by primary polydipsia in a 70-year-old woman after experiencing a stressful event. The patient's increased usage of Desmopressin led to hyponatremia and altered consciousness, prompting a comprehensive assessment. The individualized approach involved limiting fluid intake and providing psychiatric intervention. Monitoring showed successful resolution of hyponatremia, highlighting the importance of personalized strategies in managing the multifactorial aspects of diabetes insipidus and Primary polydipsia.
Conclusion: this case underscores the complexities and potential remedies for handling DI in patients with underlying psychiatric conditions, emphasizing the necessity of a collaborative approach to optimize patient outcomes.