bluuebunny/crossref_metadata_2025 huggingface dataset:
Market bidding method for the inter-provincial delivery of cascaded hydroelectric plants in day-ahead markets considering settlement rules
Authors: Han Xu , Shen Jianjian , Cheng Chuntian
Published: October 2023

Chinese electricity market reform poses huge challenges to hydropower operations and electricity trading. This study proposes a scheduling method coupling priority electricity and day-ahead trading for large hydropower plants. The study focuses on complex factors such as tariff uncertainty, different types of electricity settlement rules, and inter-provincial electricity transmission links. Spot market tariff scenarios are determined through the Latin hypercube and the K-means methods. A performance formulation of priority electricity deviation considering settlement assessment rules is established. A transmission description for different sub-plants and a triangular linear interpolation method based on binary independent branching mode are proposed to solve inter-regional transmission connections and hydraulic coupling in cascaded hydropower plants, respectively. Finally, the Big M method is employed to equivalently transform the complex non-linear problem into a mixed-integer linear programming (MILP) model. The method is verified with the day-ahead operation of four large hydropower plants downstream of the Jinsha River in China as a case study. Settlement assessment rules, inter-regional power transmission, and price uncertainty are analyzed in three different cases. Three conclusions are obtained: 1) the priority electricity performance rate and the price are positively correlated, which is useful to guide hydropower plants to actively participate in the market. 2) Introducing the prediction error of electricity price in the model can help avoid market decision risk and improve the expected return by approximately 1.2%. 3) Considering the settlement penalty rule is helpful for power generation enterprises to improve power allocation and thus seek higher revenue compared to traditional methods without considering it.
Evaluating and aggregating the grid-support capability of energy storage clusters by considering the peak regulation requirements
Authors: Li Leqing , Li Yongqi , Wan Minhui , Tan Qipeng
Published: October 2023

With the rapid progression of Energy Storage Systems (ESSs), the capability of extensively distributed and heterogeneous ESSs to support the power grid remains largely underexplored. To better exploit the potential of these numerous ESSs and enhance their service to the power grid, this paper proposes a model for evaluating and aggregating the grid-support capability of energy storage clusters by considering the peak regulation requirements. To begin with, the proposed model employs subjective and objective combination weighting methods to establish a grid-support capability matrix between ESSs indicators and grid demand scenarios, thereby facilitating the identification of the ESSs with a strong ability to regulate peak power. Next, based on the dual-peak pattern of grid load and diverse characteristics of ESSs, the ESSs in the peak regulation cluster are evaluated by clustering again. In addition, taking into account the operational constraints of the ESSs and the peak regulation requirements, a grid-support capability aggregation model for energy storage clusters based on the revised Chino polytope is proposed. The case study results demonstrate that the proposed model not only balances computational efficiency and aggregation accuracy to a certain extent but also enhances the capability of energy storage clusters to participate in peak regulation of the power grid.
Bridging citizen science and science communication: insights from a global study of science communicators
Authors: Roche Joseph , Jensen Eric A. , Jensen Aaron M. , Bell Laura , Hurley Mairéad , Taylor Aoife , Boissenin Clara , Chase Jon , Cherouvis Stephanos , Dunne Kali , Kashmina Joanne , Massarani Luisa , Planchard Joffrey , Russo Pedro , Smyth Fiona
Published: October 2023

A large study of science communicators around the world was conducted as part of the GlobalSCAPE research project. All participants in the study indicated some level of science communication experience, with more than 11% choosing “citizen scientist” as one of their identities. This paper provides an overview of how science communication and citizen science are two independent fields of research and practice that have opportunities for overlap and mutually beneficial outcomes, particularly in terms of the practices of those working in areas of public engagement with science. In addition, qualitative results are presented regarding the experience of being a science communicator for those who identified as citizen scientists. The paper also showcases the first empirical insights from the GlobalSCAPE project, which exemplifies how international research collaborations can be used to explore the challenges and opportunities faced by those individuals working in science communication and citizen science.
Connectivity, land use, and fish presence influence smooth newt (Lissotriton vulgaris) occurrence and abundance in an urban landscape
Authors: Vehkaoja Mia , Thompson Stella M. A. , Niemi Milla , Väänänen Veli-Matti
Published: October 2023

Introduction

Urban areas are challenging environments for wetland species with complex habitat requirements and life cycles. However, even semiaquatic species, representing such complex wetland groups, can be provided with adequate conditions through thorough understanding of their habitat requirements coupled with comprehensive wetland management.

Methods

We studied the occurrence and abundance of the smooth newt (Lissotriton vulgaris), a widely distributed amphibian, in an urban landscape in metropolitan Helsinki, Finland. We classified 50 randomly selected urban wetlands based on their connectivity by applying isolation scores counted using principal component analysis (PCA) and measured the occurrence and abundance of smooth newts in these locations.

Results

Our analyses showed well-connected wetland sites to differ significantly in smooth newt occurrence from both isolated and partially connected sites. Additionally, smooth newt abundance in well-connected wetlands differed from isolated sites. A PCA model with residential buildings (negative effect) and aquatic vegetation (positive effect) best explained smooth newt occurrence and total and male abundance, and female newt occurrence was best explained by a model also incorporating forest and natural open areas. Predation pressure by fish negatively influenced both smooth newt occurrence and abundance.

Discussion

Tighter networks of constructed wetlands and stricter management guidelines for urban wetland planning and fish community management could increase the suitable habitat for smooth newts in urban landscapes. Managing such areas for the common smooth newt offers potential broad benefits to the conservation of other semiaquatic amphibians and reptiles in urban wetlands and to urban wetland biodiversity in general. Our results show that smooth newt presence may indicate sustained wetland connectivity in an urban landscape and could even be used to signal successful urban planning.
Identification of coral disease within the high-latitude reef, Lord Howe Island Marine Park
Authors: Moriarty Tess , Ainsworth Tracy D. , Leggat William
Published: October 2023

Coral disease prevalence has significantly increased under a changing climate, impacting coral community structure and functionality. The impacts and ecology of coral diseases are unclear in most high-latitude reefs (coral reefs above 28° north and below 28° south). High-latitude locations are vulnerable to climate change; therefore, identifying diseases and developing region-specific baselines are important for local management. We report the first coral disease findings at the UNESCO World Heritage listed Lord Howe Island Marine Park (31.5°S, 159°E), the southernmost coral reef system. This study assessed coral disease prevalence during November 2018, March 2019 and October 2019. Surveys from three lagoonal reefs identified four coral diseases: white syndrome, skeletal eroding band, growth anomalies and endolithic hypermycosis impacting six coral taxa (Acropora, Isopora, Montipora, Pocillopora, Porites and Seriatopora). Overall, disease prevalence was 5 ± 1% and significantly differed between time and site. Disease prevalence was highest in November 2018 (10 ± 1%) and significantly lower during March 2019 (5 ± 1%), coinciding with a bleaching event. White syndrome was the most prevalent disease (4 ± 1%) with 83 colonies of six taxa affected, predominately Isopora. Acroporids recorded the highest disease susceptibility, with three of the four diseases observed. Documenting baseline coral disease prevalence and monitoring throughout a bleaching event assists our understanding of disease ecology dynamics under current climate change impacts at high-latitude reefs.
Heterologous prime-boost H1N1 vaccination exacerbates disease following challenge with a mismatched H1N2 influenza virus in the swine model
Authors: Pliasas Vasilis C. , Neasham Peter J. , Naskou Maria C. , Neto Rachel , Strate Philip G. , North J. Fletcher , Pedroza Stephen , Chastain Strickland D. , Padykula Ian , Tompkins S. Mark , Kyriakis Constantinos S.
Published: October 2023

Influenza A viruses (IAVs) pose a significant threat to both human and animal health. Developing IAV vaccine strategies able to elicit broad heterologous protection against antigenically diverse IAV strains is pivotal in effectively controlling the disease. The goal of this study was to examine the immunogenicity and protective efficacy of diverse H1N1 influenza vaccine strategies including monovalent, bivalent, and heterologous prime-boost vaccination regimens, against a mismatched H1N2 swine influenza virus. Five groups were homologous prime-boost vaccinated with either an oil-adjuvanted whole-inactivated virus (WIV) monovalent A/swine/Georgia/27480/2019 (GA19) H1N2 vaccine, a WIV monovalent A/sw/Minnesota/A02636116/2021 (MN21) H1N1 vaccine, a WIV monovalent A/California/07/2009 (CA09) H1N1, a WIV bivalent vaccine composed of CA09 and MN21, or adjuvant only (mock-vaccinated group). A sixth group was prime-vaccinated with CA09 WIV and boosted with MN21 WIV (heterologous prime-boost group). Four weeks post-boost pigs were intranasally and intratracheally challenged with A/swine/Georgia/27480/2019, an H1N2 swine IAV field isolate. Vaccine-induced protection was evaluated based on five critical parameters: (i) hemagglutination inhibiting (HAI) antibody responses, (ii) clinical scores, (iii) virus titers in nasal swabs and respiratory tissue homogenates, (iv) BALf cytology, and (v) pulmonary pathology. While all vaccination regimens induced seroprotective titers against homologous viruses, heterologous prime-boost vaccination failed to enhance HAI responses against the homologous vaccine strains compared to monovalent vaccine regimens and did not expand the scope of cross-reactive antibody responses against antigenically distinct swine and human IAVs. Mismatched vaccination regimens not only failed to confer clinical and virological protection post-challenge but also exacerbated disease and pathology. In particular, heterologous-boosted pigs showed prolonged clinical disease and increased pulmonary pathology compared to mock-vaccinated pigs. Our results demonstrated that H1-specific heterologous prime-boost vaccination, rather than enhancing cross-protection, worsened the clinical outcome and pathology after challenge with the antigenically distant A/swine/Georgia/27480/2019 strain.
Preclinical study of CD19 detection methods post tafasitamab treatment
Authors: Ilieva Kristina , Eberl Markus , Jaehrling Jan , Blair Derek , Patra-Kneuer Maria , Boxhammer Rainer , Alvarez Arias Diana , Heitmüller Christina
Published: October 2023

Introduction

Several CD19 targeted antibody-based therapeutics are currently available for patients with diffuse large B-cell lymphoma (DLBCL), including the Fc-modified antibody immunotherapy tafasitamab. This therapeutic landscape warrants the evaluation of potential sequencing approaches. Prior to a subsequent CD19-targeted therapy, CD19 expression on tafasitamab-treated patient biopsy samples may be assessed. However, no standardized methods for its detection are currently available. In this context, selecting a tafasitamab-competing CD19 detection antibody for immunohistochemistry (IHC) or flow cytometry (FC) may lead to misinterpreting epitope masking by tafasitamab as antigen loss or downregulation.

Methods

We analyzed a comprehensive panel of commercially available CD19 detection antibody clones for IHC and FC using competition assays on tafasitamab pre-treated cell lines. To remove bound tafasitamab from the cell surface, an acidic dissociation protocol was used. Antibody affinities for CD19 were measured using Surface Plasmon Resonance (SPR) or Bio-Layer Interferometry (BLI).

Results

While CD19 was successfully detected on tafasitamab pre-treated samples using all 7 tested IHC antibody clones, all 8 tested FC antibody clones were confirmed to compete with tafasitamab. An acidic dissociation was demonstrated essential to circumvent CD19 masking by tafasitamab and avoid false negative FC results.

Discussion

The current study highlights the importance of selecting appropriate CD19 detection tools and techniques for correct interpretation of CD19 expression. The findings presented herein can serve as a guideline to investigators and may help navigate treatment strategies in the clinical setting.
Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process
Authors: Gu Min , Jin Yuexinzi , Gao Xun , Xia Wenying , Xu Ting , Pan Shiyang
Published: October 2023

Interleukin-37 (IL-37) is a newly discovered member of IL-1 family. The cytokine was proved to have extensive protective effects in infectious diseases, allergic diseases, metabolic diseases, autoimmune diseases and tumors since its discovery. IL-37 was mainly produced by immune and some non-immune cells in response to inflammatory stimulus. The IL-37 precursors can convert into the mature forms after caspase-1 cleavage and activation intracellularly, and then bind to Smad-3 and transfer to the nucleus to inhibit the production and functions of proinflammatory cytokines; extracellularly, IL-37 binds to cell surface receptors to form IL-37/IL-18Rα/IL-1R8 complex to exert immunosuppressive function via inhibiting/activating multiple signal pathways. In addition, IL-37 can attenuate the pro-inflammatory effect of IL-18 through directly or forming an IL-37/IL-18BP/IL-18Rβ complex. Therefore, IL-37 has the ability to suppress innate and acquired immunity of the host, and effectively control inflammatory stimulation, which was considered as a new hallmark of cancer. Specifically, it is concluded that IL-37 can inhibit the growth and migration of tumor cells, prohibit angiogenesis and mediate the immunoregulation in tumor microenvironment, so as to exert effective anti-tumor effects. Importantly, latest studies also showed that IL-37 may be a novel therapeutic target for cancer monitoring. In this review, we summarize the immunoregulation roles and mechanisms of IL-37 in anti-tumor process, and discuss its progress so far and potential as tumor immunotherapy.
Integration of untargeted metabolomics and microbial community analyses to characterize distinct deep-sea methane seeps
Authors: Redick Margaret A. , Cummings Milo E. , Neuhaus George F. , Ardor Bellucci Lila M. , Thurber Andrew R. , McPhail Kerry L.
Published: October 2023

Deep-sea methane seeps host highly diverse microbial communities whose biological diversity is distinct from other marine habitats. Coupled with microbial community analysis, untargeted metabolomics of environmental samples using high resolution tandem mass spectrometry provides unprecedented access to the unique specialized metabolisms of these chemosynthetic microorganisms. In addition, the diverse microbial natural products are of broad interest due to their potential applications for human and environmental health and well-being. In this exploratory study, sediment cores were collected from two methane seeps (-1000 m water depth) with very different gross geomorphologies, as well as a non-seep control site. Cores were subjected to parallel metabolomic and microbial community analyses to assess the feasibility of representative metabolite detection and identify congruent patterns between metabolites and microbes. Metabolomes generated using high resolution liquid chromatography tandem mass spectrometry were annotated with predicted structure classifications of the majority of mass features using SIRIUS and CANOPUS. The microbiome was characterized by analysis of 16S rRNA genes and analyzed both at the whole community level, as well as the small subgroup of Actinobacteria, which are known to produce societally useful compounds. Overall, the younger Dagorlad seep possessed a greater abundance of metabolites while there was more variation in abundance, number, and distribution of metabolites between samples at the older Emyn Muil seep. Lipid and lipid-like molecules displayed the greatest variation between sites and accounted for a larger proportion of metabolites found at the older seep. Overall, significant differences in composition of the microbial community mirrored the patterns of metabolite diversity within the samples; both varied greatly as a function of distance from methane seep, indicating a deterministic role of seepage. Interdisciplinary research to understand microbial and metabolic diversity is essential for understanding the processes and role of ubiquitous methane seeps in global systems and here we increase understanding of these systems by visualizing some of the chemical diversity that seeps add to marine systems.
Fe(III) (oxyhydr)oxide reduction by the thermophilic iron-reducing bacterium Desulfovulcanus ferrireducens
Authors: Sklute Elizabeth C. , Leopo Deborah A. , Neat Kaylee A. , Livi Kenneth J. T. , Dyar M. Darby , Holden James F.
Published: October 2023

Some thermophilic bacteria from deep-sea hydrothermal vents grow by dissimilatory iron reduction, but our understanding of their biogenic mineral transformations is nascent. Mineral transformations catalyzed by the thermophilic iron-reducing bacterium Desulfovulcanus ferrireducens during growth at 55°C were examined using synthetic nanophase ferrihydrite, akaganeite, and lepidocrocite separately as terminal electron acceptors. Spectral analyses using visible-near infrared (VNIR), Fourier-transform infrared attenuated total reflectance (FTIR-ATR), and Mössbauer spectroscopies were complemented with x-ray diffraction (XRD) and transmission electron microscopy (TEM) using selected area electron diffraction (SAED) and energy dispersive X-ray (EDX) analyses. The most extensive biogenic mineral transformation occurred with ferrihydrite, which produced a magnetic, visibly dark mineral with spectral features matching cation-deficient magnetite. Desulfovulcanus ferrireducens also grew on akaganeite and lepidocrocite and produced non-magnetic, visibly dark minerals that were poorly soluble in the oxalate solution. Bioreduced mineral products from akaganeite and lepidocrocite reduction were almost entirely absorbed in the VNIR spectroscopy in contrast to both parent minerals and the abiotic controls. However, FTIR-ATR and Mössbauer spectra and XRD analyses of both biogenic minerals were almost identical to the parent and control minerals. The TEM of these biogenic minerals showed the presence of poorly crystalline iron nanospheres (50–200 nm in diameter) of unknown mineralogy that were likely coating the larger parent minerals and were absent from the controls. The study demonstrated that thermophilic bacteria transform different types of Fe(III) (oxyhydr)oxide minerals for growth with varying mineral products. These mineral products are likely formed through dissolution-reprecipitation reactions but are not easily predictable through chemical equilibrium reactions alone.
Shared genetic architecture of COVID-19 and Alzheimer’s disease
Authors: Matveeva Natalia , Kiselev Ivan , Baulina Natalia , Semina Ekaterina , Kakotkin Viktor , Agapov Mikhail , Kulakova Olga , Favorova Olga
Published: October 2023

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the сoronavirus disease 2019 (COVID-19) have become a global health threat. At the height of the pandemic, major efforts were focused on reducing COVID-19-associated morbidity and mortality. Now is the time to study the long-term effects of the pandemic, particularly cognitive impairment associated with long COVID. In recent years much attention has been paid to the possible relationship between COVID-19 and Alzheimer’s disease, which is considered a main cause of age-related cognitive impairment. Genetic predisposition was shown for both COVID-19 and Alzheimer’s disease. However, the analysis of the similarity of the genetic architecture of these diseases is usually limited to indicating a positive genetic correlation between them. In this review, we have described intrinsic linkages between COVID-19 and Alzheimer’s disease, pointed out shared susceptibility genes that were previously identified in genome-wide association studies of both COVID-19 and Alzheimer’s disease, and highlighted a panel of SNPs that includes candidate genetic risk markers of the long COVID-associated cognitive impairment.
The effect of flaxseed supplementation on sex hormone profile in adults: a systematic review and meta-analysis
Authors: Musazadeh Vali , Nazari Ahmad , Natami Mohammad , Hajhashemy Zahra , Kazemi Kimia Sadat , Torabi Fereshte , Moridpour Amir Hossein , Vajdi Mahdi , Askari Gholamreza
Published: October 2023

Inconsistent data suggest that flaxseed supplementation may have a role in sex hormones. We aimed to carry out a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating effects of flaxseed supplementation on sex hormone profile. PubMed, Scopus, Embase, Cochrane Library, Web of Science databases, and Google Scholar were searched up to March 2023. Standardized mean difference (SMD) was pooled using a random-effects model. Sensitivity analysis, heterogeneity, and publication bias were reported using standard methods. The quality of each study was evaluated with the revised Cochrane risk-of-bias tool for randomized trials, known as RoB 2. Finding from ten RCTs revealed that flaxseed supplementation had no significant alteration in follicle-stimulating hormone (FSH) (SMD: −0.11; 95% CI: −0.87, 0.66: p = 0.783), sex hormone-binding globulin (SHBG) (SMD: 0.35; 95% CI: −0.02, 0.72; p = 0.063), total testosterone (TT) levels (SMD: 0.17; 95% CI: −0.07, 0.41; p = 0.165), free androgen index (FAI) (SMD = 0.11, 95% CI: −0.61, 0.83; p = 0.759), and dehydroepiandrosterone sulfate (DHEAS) (SMD: 0.08, 95%CI: −0.55, 0.72, p = 0.794). Flaxseed supplementation had no significant effect on sex hormones in adults. Nevertheless, due to the limited included trials, this topic is still open and needs further studies in future RCTs.
This seems fishy: Technology-Critical Elements as a growing concern to aquatic biota and elasmobranchs in particular
Authors: Hauser-Davis Rachel Ann
Published: October 2023

Human activities have significantly impacted our natural environments, resulting in extensive degradation, with chemical contamination emerging as a critical concern. This type of pollution has far-reaching implications, affecting ecological health and socioeconomic dimensions. The concept of “contaminants of emerging concern” encompasses newly recognized environmental pollutants, highlighting their diverse and often understudied effects. This category includes microplastics, antibiotics, pharmaceuticals, and metals, among others, many of which lack adequate regulations and understanding of their ecological and human impacts. A subset of these pollutants, termed Technology-Critical Elements (TCEs), holds significance in high-tech industries but also poses environmental challenges due to increased extraction, manufacturing, and disposal. Aquatic environments, the ultimate chemical contaminant sinks, require heightened attention with regard to TCE dynamics and effects. Despite increasing research on TCEs in various aquatic taxa, a lack of comprehensive data hinders further knowledge assessments. In this scenario, fish, key environmental health indicators and links to human contamination, demand focused studies. Cartilaginous fish, specifically, are often overlooked, although ecologically and economically significant, warranting research into TCE effects. This type of research displays the potential to shed light on TCE dynamics, ecological outcomes, and guide conservation strategies for these species and their habitat, also aligning with the One Health concept, acknowledging the interconnectedness of humans, animals, and the environment and contributing to SDG goals, underpinning marine ecosystem conservation.
Role of cancer-associated fibroblasts in the progression, therapeutic resistance and targeted therapy of oesophageal squamous cell carcinoma
Authors: Xue Mengying , Tong Yusuo , Xiong Yaozu , Yu Changhua
Published: October 2023

Oesophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant tumours with high morbidity and mortality. Although surgery, radiotherapy and chemotherapy are common treatment options available for oesophageal cancer, the 5-year survival rate remains low after treatment. On the one hand, many oesophageal cancers are are discovered at an advanced stage and, on the other hand, treatment resistance is a major obstacle to treating locally advanced ESCC. Cancer-associated fibroblasts (CAFs), the main type of stromal cell in the tumour microenvironment, enhance tumour progression and treatment resistance and have emerged as a major focus of study on targeted therapy of oesophageal cancer.With the aim of providing potential, prospective targets for improving therapeutic efficacy, this review summarises the origin and activation of CAFs and their specific role in regulating tumour progression and treatment resistance in ESCC. We also emphasize the clinical potential and emerging trends of ESCC CAFs-targeted treatments.
Lipid metabolism reprogramming in head and neck cancer
Authors: Liang Jinfeng , Li Lin , Li Limei , Zhou Xiaoying , Zhang Zhe , Huang Yi , Xiao Xue
Published: October 2023

Lipid metabolism reprogramming is one of the most prominent metabolic anomalies in cancer, wherein cancer cells undergo dysregulation of lipid metabolism to acquire adequate energy, cell membrane building blocks, as well as signaling molecules essential for cell proliferation, survival, invasion, and metastasis. These adaptations enable cancer cells to effectively respond to challenges posed by the tumor microenvironment, leading to cancer therapy resistance and poor cancer prognosis. Head and neck cancer, ranking as the seventh most prevalent cancer, exhibits numerous abnormalities in lipid metabolism. Nevertheless, the precise role of lipid metabolic rewiring in head and neck cancer remains unclear. In line with the LIPID MAPS Lipid Classification System and cancer risk factors, the present review delves into the dysregulated molecules and pathways participating in the process of lipid uptake, biosynthesis, transportation, and catabolism. We also present an overview of the latest advancements in understanding alterations in lipid metabolism and how they intersect with the carcinogenesis, development, treatment, and prognosis of head and neck cancer. By shedding light on the significance of metabolic therapy, we aspire to improve the overall prognosis and treatment outcomes of head and neck cancer patients.
The Hippo pathway in endometrial cancer: a potential therapeutic target?
Authors: Shen Xinyun , Li Qianqian , Sun Yiqing , Chen Lingli , Xue Fengxia , Tian Wenyan , Wang Yingmei
Published: October 2023

Endometrial cancer, one of the most prevalent malignant cancers tumors of the female reproductive tract, has been increasing in incidence and mortality rates around the world. The Hippo pathway, one of the eight traditional human cancer signaling pathways, is an intricate signaling network that regulates cell proliferation, differentiation, and migration as well as restricting organ size in response to a range of intracellular and extracellular signals. Inhibiting the Hippo pathway results in aberrant activation of its downstream core component YAP/TAZ, which can enhance cancer cells’ metabolism and maintain their stemness. Additionally, the Hippo pathway can modulate the tumor microenvironment and induce drug resistance, where tumorigenesis and tumor progression occur. However, the Hippo pathway has been little researched in endometrial cancer. Here, we aim to review how the Hippo pathway contributes to the onset, development and the potential treatment of endometrial cancer with the aim of providing new therapeutic targets.
Potential of medicinal plants as antimalarial agents: a review of work done at Kenya Medical Research Institute
Authors: Irungu Beatrice , Okari Erick , Nyangi Mary , Njeru Sospeter , Koech Lilian
Published: October 2023

Background: Medicinal plants have traditionally been used as remedies against malaria. The present review attempted to compile data on scientific research evidence on antimalarial medicinal plants screened at Kenya Medical Research Institute (KEMRI), Center for Traditional Medicine and Drug (CTMDR) Research from January 2003 to December 2021.

Methods: A systematic review was conducted using a predefined protocol based on PRISMA. Search was performed in Google Scholar and PubMed. One hundred and eight journal articles were identified 37 of which published on antimalarial/antiplasmodial work. Thirty journal articles with at least one author from KEMRI-CTMDR and accessible in full were selected for analysis. Relevant data was captured in MS Excel format and descriptive statistics, percentages and tables used to summarize the findings.

Results: Assessment of individual plant species was considered as an independent study resulting in 1170 antiplasmodial/antimalarial tests done from 197 plant species. One hundred and fifty plant species were screened in vitro, one in vivo and 46 were both in vivo and in vitro. Three hundred and forty-four of tests reported good activity (IC50 < 10 μg/mL or parasite suppression rate of ≥50%), 414 moderate activity (IC50 values of 10–49 μg/mL or parasite suppression rate of 30%–49%) and 412 were reports of inactivity (IC50 ˃ 50 μg/mL or parasite suppression rate of <30%). Fuerstia africana and Ludwigia erecta were reported to have the highest activities, with IC50 < 1 μg/mL against Plasmodium falciparum D6 strain and chemosuppression in mice at an oral dose of 100 mg/kg, was reported as 61.9% and 65.3% respectively. Fifty five antimalarial/antiplasmodial active compounds isolated from eight plant species were reported with resinone (39) having the best activity (IC50 < 1 μg/mL).

Conclusion: Though 344 of tests reported promising antimalarial activity, it was noted that there was limited evaluation of these plants in animal models, with only 9.0% (105/1170) studies and no clinical trials. This highlights an important research gap emphasizing the need for drug development studies that aim to progress study findings from preclinical to clinical studies. There is still need for extensive research on promising plant species aimed at developing new plant based antimalarial drugs.
Effects of cilengitide derivatives on TGF-β1-induced epithelial-to-mesenchymal transition and invasion in gefitinib-resistant non-small cell lung cancer cells
Authors: Seo Yujin , Seo Minji , Kim Jiyeon
Published: October 2023

Long-term administration of tyrosine kinase inhibitors (TKIs) used for the treatment of non-small cell lung cancer (NSCLC) induces TKI resistance in cells. The appearance of resistant cells requires the combined administration of another therapeutic agent and may cause side effects in the gastrointestinal and central nervous system. In previous studies, we found that derivatives of cilengitide, a cyclic Arg-Gly-Asp (RGD) peptide, exert NSCLC apoptotic and anti–epithelial-mesenchymal transition (EMT) effects. In particular, cRGDwV and cRGDyV, which are cyclic peptides containing aromatic amino acids, were found to inhibit NSCLC cell growth, TGF-β1-induced EMT, and invasion. In this study, we confirmed the effects of cRGDwV and cRGDyV on proliferation, TGF-β1-induced EMT marker expression, migration, and invasion in gefitinib-resistant NSCLC A549 (A549GR) cells. In A549GR cells, cRGDwV and cRGDyV showed inhibitory effects on the expression of mesenchymal marker expression, migration, and invasion. These results indicate that cyclic RGD peptides containing aromatic amino acids can be used to inhibit mesenchymal marker expression as well as migration and invasion in gefitinib-resistant cells.
Specificity in plant-mycorrhizal fungal relationships: prevalence, parameterization, and prospects
Authors: d’Entremont Tyler W. , Kivlin Stephanie N.
Published: October 2023

Species interactions exhibit varying degrees of specialization, ranging from generalist to specialist interactions. For many interactions (e.g., plant-microbiome) we lack standardized metrics of specialization, hindering our ability to apply comparative frameworks of specificity across niche axes and organismal groups. Here, we discuss the concept of plant host specificity of arbuscular mycorrhizal (AM) fungi and ectomycorrhizal (EM) fungi, including the predominant theories for their interactions: Passenger, Driver, and Habitat Hypotheses. We focus on five major areas of interest in advancing the field of plant-mycorrhizal fungal host specificity: phylogenetic specificity, host physiology specificity, functional specificity, habitat specificity, and mycorrhizal fungal-mediated plant rarity. Considering the need to elucidate foundational concepts of specificity in this globally important symbiosis, we propose standardized metrics and comparative studies to enhance our understanding. We also emphasize the importance of analyzing global mycorrhizal data holistically to draw meaningful conclusions and suggest a shift toward single-species analyses to unravel the complexities underlying these associations.
Language models and psychological sciences
Authors: Sartori Giuseppe , Orrù Graziella
Published: October 2023

Large language models (LLMs) are demonstrating impressive performance on many reasoning and problem-solving tasks from cognitive psychology. When tested, their accuracy is often on par with average neurotypical adults, challenging long-standing critiques of associative models. Here we analyse recent findings at the intersection of LLMs and cognitive science. Here we discuss how modern LLMs resurrect associationist principles, with abilities like long-distance associations enabling complex reasoning. While limitations remain in areas like causal cognition and planning, phenomena like emergence suggest room for growth. Providing examples and increasing the dimensions of the network are methods that further improve LLM abilities, mirroring facilitation effects in human cognition. Analysis of LLMs errors provides insight into human cognitive biases. Overall, we argue LLMs represent a promising development for cognitive modelling, enabling new explorations of the mechanisms underlying intelligence and reasoning from an associationist point of view. Carefully evaluating LLMs with the tools of cognitive psychology will further understand the building blocks of the human mind.
A novel intervention for treating adults with ADHD using peripheral visual stimulation
Authors: Richter Yael , Gordon Carlos , Vainstein Gabriel , Bublil-Mor Carmel , Geisinger Dario , Meital-Kfir Noya , Elyoseph Zohar
Published: October 2023

Objective

Stimulation of the peripheral visual field has been previously reported as beneficial for cognitive performance in ADHD. This study assesses the safety and efficacy of a novel intervention involving peripheral visual stimuli in managing attention deficit hyperactivity disorder (ADHD).

Methods

One hundred and eight adults, 18–40 years old, with ADHD, were enrolled in a two-month open-label study. The intervention (i.e., Neuro-glasses) consisted of standard eyeglasses with personalized peripheral visual stimuli embedded on the lenses. Participants were assessed at baseline and at the end of the study with self-report measures of ADHD symptoms (the Adult ADHD Self-Report Scale; ASRS), and executive functions (The Behavior Rating Inventory of Executive Function Adult Version; BRIEF-A). A computerized test of continuous performance (The Conners’ Continuous Performance Test-3; CPT-3) was tested at baseline with standard eyeglasses and at the end of study using Neuro-glasses. The Clinical Global Impression-Improvement scale (CGI-I) was assessed at the intervention endpoint. Safety was monitored by documentation of adverse events.

Results

The efficacy analysis included 97 participants. Significant improvements were demonstrated in self-reported measures of inattentive symptoms (ASRS inattentive index; p = 0.037) and metacognitive functions concerning self-management and performance monitoring (BRIEF-A; p = 0.029). A continuous-performance test (CPT-3) indicated significant improvement in detectability (d’; p = 0.027) and reduced commission errors (p = 0.004), suggesting that the Neuro-glasses have positive effects on response inhibition. Sixty-two percent of the participants met the response criteria assessed by a clinician (CGI-I). No major adverse events were reported.

Conclusion

Neuro-glasses may offer a safe and effective approach to managing adult ADHD. Results encourage future controlled efficacy studies to confirm current findings in adults and possibly children with ADHD.

Clinical trial registration: https://www.clinicaltrials.gov/, Identifier NCT05777785.
Exploring disparities and novel insights into metabolic and cardiovascular comorbidities among COVID-19 patients in Mexico
Authors: López-Cuevas Jonathan Ariel , Martínez-García Mireya , Hernández-Lemus Enrique , Anda-Jáuregui Guillermo de
Published: October 2023

Introduction

The COVID-19 pandemic, especially its early stages, sparked extensive discussions regarding the potential impact of metabolic and cardiovascular comorbidities on the severity and fatality of SARS-CoV-2 infection, yielding inconclusive outcomes. In this study, we delve into the prevalence of metabolic and cardiovascular comorbidities within COVID-19 patients in Mexico.

Methods

Employing a retrospective observational study design, we collected data from official databases encompassing COVID-19 patients admitted to both public and private hospitals in Mexico City.

Results

Our investigation unveiled a noteworthy incongruity in the prevalence of metabolic and cardiovascular comorbidities among COVID-19 patients, with a particular emphasis on obesity, hypertension, and diabetes. This incongruity manifests as location-dependent phenomena, where the prevalence of these comorbidities among COVID-19 patients significantly deviates from the reported values for the general population in each specific location.

Discussion

These findings underscore the critical importance of screening for metabolic and cardiovascular comorbidities in COVID-19 patients and advocate for the necessity of tailored interventions for this specific population. Furthermore, our study offers insights into the intricate interplay between COVID-19 and metabolic and cardiovascular comorbidities, serving as a valuable foundation for future research endeavors and informing clinical practice.
Person-centered care for people with aphasia: tools for shared decision-making
Authors: Hinckley Jacqueline , Jayes Mark
Published: October 2023

Shared decision-making is a fundamental aspect of person-centered care, and can and should be part of many different aspects of the rehabilitation process. Communication disabilities like aphasia, which affects people's ability to use and understand spoken and written language, can make shared decision-making especially challenging to the resources and skills of rehabilitation practitioners. The purpose of this narrative review is to provide a comprehensive description of tools that can support successful shared decision-making with people with aphasia in the rehabilitation environment. These tools and strategies are appropriate for use by physicians, nurses, social workers, physical therapists (also referred to as physiotherapists), occupational therapists, and other service or care providers. The important role of speech-language pathologists as consultants is also described. Case scenarios throughout the paper illustrate the application of recommended tools and strategies along with best practices.
Neuromechanics of finger hangs with arm lock-offs: analyzing joint moments and muscle activations to improve practice guidelines for climbing
Authors: Exel Juliana , Deimel David , Koller Willi , Werle Cäcilia , Baca Arnold , Maffiodo Daniela , Sesana Raffaella , Colombo Alessandro , Kainz Hans
Published: October 2023

Introduction

Climbing imposes substantial demands on the upper limbs and understanding the mechanical loads experienced by the joints during climbing movements is crucial for injury prevention and optimizing training protocols. This study aimed to quantify and compare upper limb joint loads and muscle activations during isometric finger hanging exercises with different arm lock-off positions.

Methods

Seventeen recreational climbers performed six finger dead hangs with arm lock-offs at 90° and 135° of elbow flexion, as well as arms fully extended. Upper limb joint moments were calculated using personalized models in OpenSim, based on three-dimensional motion capture data and forces measured on an instrumented hang board. Muscle activations of upper limb muscles were recorded with surface electromyography electrodes.

Results

Results revealed that the shoulder exhibited higher flexion moments during arm lock-offs at 90° compared to full extension (p = 0.006). The adduction moment was higher at 135° and 90° compared to full extension (p < 0.001), as well as the rotation moments (p < 0.001). The elbows exhibited increasing flexion moments with the increase in the arm lock-off angle (p < 0.001). Muscle activations varied across conditions for biceps brachii (p < 0.001), trapezius (p < 0.001), and latissimus dorsi, except for the finger flexors (p = 0.15).

Discussion

Our findings indicate that isometric finger dead hangs with arms fully extended are effective for training forearm force capacities while minimizing stress on the elbow and shoulder joints. These findings have important implications for injury prevention and optimizing training strategies in climbing.
Platelet-rich plasma combined with lyophilizing thrombin powder for the treatment of complicated enterocutaneous fistula: a case report
Authors: He Chao , Liu Kui , Zhao Zhijie , Lai Zhihao , Qu Linlin
Published: October 2023

Background

Enterocutaneous fistula is one of the most challenging problems facing surgeons. In severe cases, a large amount of fluid loss can lead to problems such as water and electrolyte acid-base imbalance, malnutrition, infection, and organ dysfunction. Here we reported a case of platelet-rich plasma combined with lyophilizing thrombin powder for the treatment of complicated enterocutaneous fistula.

Case presentation

A 48-year-old male, more than 2 years after the operation of abdominal trauma, the leakage of the fistula in the right upper abdominal wall was accompanied by fever for 3 days. The Contrast Fistulography and upper abdomen CT accurately depicted the entry of the meglumine diatrizoate into the small intestine through the small fistula. The patient had a large abdominal wall defect and severe intestinal adhesions. Reoperation may lead to more serious ECF. Therefore, we decided to seal the fistulas with PRP combined with lyophilizing thrombin powder.

Conclusions

The findings in this case report suggest that the combination of PRP and lyophilized thrombin powder holds promise as a viable approach for managing ECF in patients with chronic abdominal wall fistulas, as it appears to facilitate fistula closure, reduce healing time, and improve patient outcomes
The effect of feeding fermented distillers' grains diet on the intestinal metabolic profile of Guanling crossbred cattle
Authors: Luo Xiaofen , Zhang Tiantian , Xu Duhan , Zhu Mingming , Zhang Junjie , Zhang Rong , Hu Qian , Wang Yongxuan , He Guangxia , Chen Ze , Mei Shihui , Zhou Bijun , Wang Kaigong , Chen Chao , Zhu Erpeng , Cheng Zhentao
Published: October 2023

Fermented distiller's grains (FDG)-based diets are nutritious and can improve the growth and intestinal immunity in livestock. However, there is limited research examining the effect of feeding FDG-based diets on changes in intestinal metabolites and related pathways in livestock. In this study, nine Guanling crossbred cattle (Guizhou Guanling Yellow cattle × Simmental cattle) were selected and randomly divided into a basal diet (BD) group and two experimental groups fed with FDG replacing 15% and 30% of the daily ration concentrates (FDG-Case A and FDG-Case B), respectively, with three cattle in each group. Fresh jejunum (J) and cecum (C) tissues were collected for metabolomic analysis. Differential metabolites and metabolic pathways were explored by means of univariate and multivariate statistical analysis. Compared with the J-BD group, 30 and 100 differential metabolites (VIP > 1, p < 0.05) were obtained in the J-FDG-Case A group and J-FDG-Case B group, respectively, and the J-FDG-Case B vs. J-FDG-Case A comparison revealed 63 significantly differential metabolites, which were mainly divided into superclasses including lipids and lipid-like molecules, organoheterocyclic compounds, and organic acids and derivatives. Compared with the C-BD, 3 and 26 differential metabolites (VIP > 1, p < 0.05) were found in the C-FDG-Case A group and C-FDG-Case B group, respectively, and the C-FDG-Case B vs. C-FDG-Case A comparison revealed 21 significantly different metabolites, which were also mainly divided into superclasses including lipids and lipid-like molecules, organoheterocyclic compounds, and organic acids and derivatives. A total of 40 metabolic pathways were identified, with a significance threshold set at p < 0.05. Among them, 2, 14, and 18 metabolic pathways were significantly enriched in the J-FDG-Case A vs. J-BD, J-FDG-Case B vs. J-BD, and J-FDG-Case B vs. J-FDG-Case A comparisons, respectively. Meanwhile, 1, 2, and 3 metabolic pathways were obtained in the C-FDG-Case A vs. C-BD, C-FDG-Case B vs. C-BD, and C-FDG-Case B vs. C-FDG-Case A comparisons, respectively. Furthermore, four significant metabolic pathways, namely insulin resistance, biosynthesis of unsaturated fatty acids, linoleic acid metabolism, and primary bile acid biosynthesis, were significantly enriched in Guanling crossbred cattle fed FDG diets. These results suggest that feeding FDG diets may promote the growth and intestinal immunity of Guanling crossbred cattle by regulating metabolic patterns of lipid compounds and related metabolic pathways. This study sheds light on the potential metabolic regulatory mechanisms of FDG diets and offers some references for their use in livestock feed.