bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of Multimodal Neuroimaging in the Treatment of Neurological Patients
Authors: Zhang Lixia , Li Guiyang , Zhang Lunzhong
Published: May 2022

Objective. In order to study the application of multimodal neuroimaging in the treatment of neurological patients, the brain of patients was scanned and identified through multimodal neuroimaging, so as to provide basis for doctors to judge their diseases and give treatment plans. Method. Understand the principle of multimodal neural scene currently used through literature analysis, analyze the current level of neurological diseases in the medical field and the application of multimodal neural image in diseases, recalculate the imaging examination data through neurofuzzy algorithm, and obtain a more optimized identification method than the previous visual judgment method. Result. The image inspection data is dimensioned through computer spatial convolution. At this time, the output two-dimensional array is not accurate enough. It needs to be processed again through fuzzy spatial convolution to obtain relatively accurate data output, generate a small two-dimensional array, and use the convolution core for the spatial convolution process of two-dimensional array. The algorithm uses neural network machine learning algorithm to identify and judge the inspection data. Conclusion. Through this algorithm to identify the examination data, the early diagnosis sensitivity of intracranial space occupying lesions and intracranial hematogenous lesions are more than 20% higher than the previous traditional recognition methods, which provides a medical imaging basis for the early diagnosis and treatment of acoustic diseases, and improves the treatment probability and prognosis quality of life of neurological patients.
In the Direction of Service Guarantees for Virtualized Network Functions
Authors: Rathore Muhammad Siraj , Ahmad Naveed , Kohli Rashi , Iqbal Jawaid , Alroobaea Roobaea , Hussain Saddam , Ullah Syed Sajid , Umar Fazlullah
Published: May 2022

The trend of consolidating network functions from specialized hardware to software running on virtualization servers brings significant advantages for reducing costs and simplifying service deployment. However, virtualization techniques have significant limitations when it comes to networking as there is no support for guaranteeing that network functions meet their service requirements. In this paper, we present a design for providing service guarantees to virtualized network functions based on rate control. The design is a combination of rate regulation through token bucket filters and the regular scheduling mechanisms in operating systems. It has the attractive property that traffic profiles are maintained throughout a series of network functions, which makes it well suited for service function chaining. We discuss implementation alternatives for the design and demonstrate how it can be implemented on two virtualization platforms: LXC containers and the KVM hypervisor. To evaluate the design, we conduct experiments where we measure throughput and latency using IP forwarders (routers) as examples of virtual network functions. Two significant factors for performance are investigated: the design of token buckets and the packet clustering effect that comes from scheduling. Finally, we demonstrate how performance guarantees are achieved for rate-controlled virtual routers under different scenarios.
Optimization Model of Logistics Task Allocation Based on Genetic Algorithm
Authors: Wang Xueli , Gao Jingjuan
Published: May 2022

In order to improve the efficiency of logistics task allocation, the rationality and algorithm of the logistics cloud task scheduling model based on genetic algorithm are proposed in this paper. Firstly, the basic principle of genetic algorithm is introduced, the logistics cooperative distribution model is constructed, and the judgment mathematical model of the transfer point of the logistics distribution demand point is constructed. Genetic algorithm is used to solve the logistics distribution path planning model, and the model is simplified. The complex multiobjective optimization problem is transformed into a single-objective optimization problem through preference vector. The genetic algorithm and open-source algorithm on Python are used to simulate the model proposed in this paper. From the change curve of the objective function, after 100 generations of iteration, the value of objective function increases rapidly from 30 to 130 and slowly from generation 5 to generations 40 to 130. Subsequently, the 40th generation to 60th generation were rapidly upgraded to 160. Finally, the 60th to 100th generations are basically stable at about 170. The cost in the scheduling process decreases gradually with the increase of the number of iterations of the algorithm, from the initial unit cost of nearly 200 to 120. Then it gradually decreases to about 80. Genetic algorithm shows the ability of efficient and accurate solution in this 100-generation iteration. The genetic algorithm is used to solve the problem. The algorithm parameters are as follows: population size pop size = 300, maximum number of iterations max gen = 200, crossover probability PC = 0.8, and mutation probability PM = 0.1. Using the data in this paper and substituting it into the model established in this paper, the following distribution scheme is obtained: p the minimum distribution cost is 601.58 yuan, the distribution vehicle is 5, and the total mileage is 477.41. After using the algorithm to optimize the path, the path interleaving is greatly reduced, and the vehicles do not take the repeated route, which can greatly save the cost. After calculation, the total mileage after optimization is 74.8% lower than that before optimization, and the cost is significantly reduced by 72.8%. To sum up, the last kilometer distribution algorithm proposed in this paper can greatly reduce the cost of logistics resource scheduling, which has obvious research significance.
OTCS: An Online Target Close-Up Shooting Method Based on the UAV Image System
Authors: Wang Wentao , Wang Huibin , Shi Xuzhou , Chen Ming
Published: May 2022

Unmanned aerial vehicles (UAV) equipped with intelligent gimbaled cameras can take images and identify specific targets from them in real-time. However, the targets in the images are generally small and difficult to be seen. This paper proposes an Online Target Close-up Shooting (OTCS) method to solve the problem of taking high-definition (HD) close-up images of the targets. Firstly, we build an online target close-up shooting model, which uses deep learning (DL) algorithm to identify the targets from the images taken online. Then, an intelligent control algorithm is presented to control the gimbaled camera to take a close-up shot of the target, which considered the target being fixed on the ground statically and moving at an ununiform speed. Finally, we build a UAV-based prototype system and conduct a series of experiments to verify our proposal. Experimental results show that our proposed method is feasible and outperforms traditional methods in effectiveness.
Research on the Application of VR Technical Ability in Political Education in Colleges and Universities
Authors: Liu Du
Published: May 2022

As an emerging multimedia technology, VR technical ability has gradually become the discuss direction of many scholars. The 3d virtual space created by computer allows users to get the feeling and depth of the real environment in VR interaction.. The application of VR technical ability in relevant disciplines that integrate both ideological and political aspects is to promote ascension of the limitations of time and space in the teaching process, to add more impetus to politics, and to continuously innovate ideas in academies and universities. The diversification of political teaching models is heightened, and teaching effects in multiple dimensions are improved.
Factors Influencing the Practice of Breast Self-Examination among Female Tertiary Students in Ho, Ghana
Authors: Amegbedzi Rosemary Ami , Komesuor Joyce , Amu Hubert , Tarkang Elvis Enowbeyang
Published: May 2022

Background. Despite the implementation of various interventions towards the reduction of breast cancer prevalence, many women still report late symptoms to health facilities, and this decreases their chances of survival. Breast self-examination (BSE) is the most convenient form of examination to detect the development of breast cancer. We examined the factors that influence the practice of breast self-examination among female tertiary students in Ho, Volta Region of Ghana. Methods. This was a descriptive cross-sectional study that recruited 506 female students from four tertiary institutions in the Ho Municipality in Ghana using questionnaires. Descriptive and inferential statistics comprising frequency, percentage, Chi-square, and binary logistic regression were used in analyzing the data. Results. About 73% of the respondents had ever practised BSE. Out of the respondents who have ever practiced BSE, 79% were practising it at the time of the study. Students in their fourth year were above 4 times more likely (95% CI = 1.73–9.29,

p
=
0.014

) to practise BSE than those in their first year. Also, students with good knowledge of BSE were 4 times more likely to practice BSE [(95% CI = 1.1–13.46),

p
=
0.036

] and students with good perception about BSE were 12 times more likely to practice BSE [(95% CI = 1.21–122.73),

p
=
0.034

]. Conclusion. The study found that 27% of the female students had never practised BSE. Those who practice BSE did not practice regularly and appropriately. Also, good knowledge and perception are associated with the practice of BSE. The implication of this result is the late presentation of breast cancer cases to health facilities and increases in breast cancer-related deaths in the country. Therefore, it is recommended that the Ministry of Health, the Ghana Health Service, and other stakeholders in Ghana’s healthcare should develop and implement innovative approaches and policies such as peer and support groups’ learning, and mass media BSE awareness aimed at ensuring better understanding and access to BSE education. This should be intensified during the foundation years such as the secondary and tertiary education levels to ensure the adoption of breast self-examination practice. It is also recommended that another study must be done using a qualitative approach to get an in-depth understanding of the steps and ways, by which female students practice BSE.
An Optimized BP Neural Network Model and Its Application in the Credit Evaluation of Venture Loans
Authors: Chen Mingkeng , Ma Xiaoyun
Published: May 2022

With the rapid development of entrepreneurship loans in China, the construction of a credit evaluation system of risk loans has become an important financial safeguard measure. This paper mainly studies the following three aspects. Firstly, in view of the subjective factors in the approval process of venture loans, based on the credit evaluation system of commercial banks and the data characteristics of venture loans, a credit evaluation system based on venture loans is constructed. Secondly, the randomized uniform design method is used to improve the population initialization method to realize the uniform distribution of the individual population. Finally, aiming at the problem of low efficiency of venture loan audit, this paper proposes an optimized BP neural network to evaluate the venture loan. Especially, through data processing, a credit index system is constructed, and then the optimized BP neural network model is determined in parameters. The model contains 15 input nodes, 1 hidden layer, and 2 output layers. Finally, the simulation shows that the optimized BP neural network model has obvious advantages in the loan evaluation. This paper includes the development status of credit evaluation of venture loans is empirically studied by using an optimized BP neural network model of nonexpected output.
Shared Psychotic Disorder in Old Age: Syndrome of Folie à Deux
Authors: Schopfer Q. , Eshmawey M.
Published: May 2022

Background. Shared psychotic disorder is a relatively rare condition first described by Lasegue and Falret in 1877, who named the syndrome “folie à deux” (FAD). This disorder is characterized by the transference of delusional ideas from one individual to another. Methods. We report the case of a mother and daughter who exhibited shared delusions of persecution after living in near-total isolation for 10 years. Both patients were hospitalized in two different wards, and the combination of separation, supportive, and pharmacological therapy resulted in remission for the mother and partial remission for the daughter. Results. Both patients were discharged, and a network was created by the psychiatric hospital which activated social workers for outpatient care. We also planned outpatient psychiatric sessions focused on the patients’ specific role in the folie à deux disease, led by two different psychiatrists. Conclusion. FAD has a long history but it is still an unconventional psychiatric diagnosis. This case report sheds light on the clinical features and how to set proper treatment strategies. While the phenomenon of FAD in old age may not be as rare as previously thought, the literature remains scarce.
Research on Optimal Control Method of Tennis Racket String Diameter Based on Kalman Filter Algorithm
Authors: Chen Xin
Published: May 2022

In order to explore the optimal control method of tennis racket string diameter, this paper applies the Kalman filter algorithm to the collection and processing of tennis sports parameters. When the Kalman filter uses the optimal gain (the Kalman filter enters the steady state), the corresponding cost function is established based on the noncorrelated nature of its residual sequence, which is used as the judgment condition for the sampling strategy switch to improve the stability of the system. In addition, this paper improves the real-time performance and calculation accuracy of data transformation through adaptive sampling strategy and adaptive scale factor, improves the stability and estimation accuracy of the system as a whole, and builds an intelligent monitoring system. Finally, this paper systematically studied the optimization control method of tennis racket string diameter and verified that the Kalman filter algorithm can play a certain role in the optimization control of tennis racket string diameter.
Targeted Radionuclide Therapy with Low and High-Dose Lutetium-177–Labeled Single Domain Antibodies Induces Distinct Immune Signatures in a Mouse Melanoma Model
Authors: Ertveldt Thomas , De Beck Lien , De Ridder Kirsten , Locy Hanne , de Mey Wout , Goyvaerts Cleo , Lecocq Quentin , Ceuppens Hannelore , De Vlaeminck Yannick , Awad Robin Maximilian , Keyaerts Marleen , Devoogdt Nick , D'Huyvetter Matthias , Breckpot Karine , Krasniqi Ahmet
Published: May 2022

Targeted radionuclide therapy (TRT) using probes labeled with Lutetium-177 (177Lu) represents a new and growing type of cancer therapy. We studied immunologic changes in response to TRT with 177Lu labeled anti-human CD20 camelid single domain antibodies (sdAb) in a B16-melanoma model transfected to express human CD20, the target antigen, and ovalbumin, a surrogate tumor antigen. High-dose TRT induced melanoma cell death, calreticulin exposure, and ATP-release in vitro. Melanoma-bearing mice received fractionated low and high-dose TRT via tumor targeting anti-human CD20 sdAbs, as opposed to control sdAbs. Tumor growth was delayed with both doses. Low- and high-dose TRT increased IL10 serum levels. Low-dose TRT also decreased CCL5 serum levels. At the tumor, high-dose TRT induced a type I IFN gene signature, while low-dose TRT induced a proinflammatory gene signature. Low- and high-dose TRT increased the percentage of PD-L1pos and PD-L2pos myeloid cells in tumors with a marked increase in alternatively activated macrophages after high-dose TRT. The percentage of tumor-infiltrating T cells was not changed, yet a modest increase in ovalbumin-specific CD8pos T-cells was observed after low-dose TRT. Contradictory, low and high-dose TRT decreased CD4pos Th1 cells in addition to double negative T cells. In conclusion, these data suggest that low and high-dose TRT induce distinct immunologic changes, which might serve as an anchoring point for combination therapy.
Presentation and Evaluation of a Manual for Heart Rate Variability Biofeedback in Somatic Symptom Disorder
Authors: Klewinghaus Laura , Martin Alexandra
Published: May 2022

Background: There is initial evidence for the efficacy of heart rate variability biofeedback (HRV-BF) in depression, anxiety disorders, and functional somatic syndromes. In somatic symptom disorder (SSD), evidence is lacking. The aim of this study was to describe a newly developed HRV-BF brief intervention and to analyze HRV changes, and to examine the applicability and acceptance in SSD. Methods: We analyzed the data of the subsample of a pilot randomized controlled trial (22 subjects with SSD) who received HRV-BF over 4 sessions. We assessed HRV (SDNN: standard deviation of the NN interval, RMSSD: root mean square of successive differences between NN interval, LF: low frequency) and the subjective evaluation and acceptance of the intervention. Results: HRV analyses within therapy sessions showed that individuals learned to increase their HRV significantly during biofeedback sessions and were able to maintain it during self-regulation periods without feedback (SDNN, RMSSD, LF: 5.7 ≤ Ft ≤ 11.1). Moreover, HRV improved across sessions (SDNN). The majority of participants rated the intervention very positively (e.g., satisfaction, improvement in mood and physical well-being). Conclusions: HRV-BF can be learned within 4 sessions and shows positive effects in patients with SSD. Adding HRV-BF to existing treatments, e.g., psychotherapy, seems promising.
Adding T2-Weighted Images to FAST1 Protocol to Evaluate the Anatomy of the Hypothalamic-Pituitary Region
Authors: Meira Altino Sá , Lyra Arthur , Kochi Cristiane , Guimarães Daniel de Faria , Nunes Arthur Castello Berchielli , Peixoto Guilherme Vieira , Zamot Stella Gallucci , e Silva Tatiane Sousa , da Rocha Antônio José , Longui Carlos Alberto
Published: May 2022

Introduction: Ectopic posterior pituitary (EPP) is a malformation of the hypothalamic-pituitary region presented as a spectrum from isolated growth hormone deficiency (GHD) to multiple pituitary hormone deficiencies (MPHDs). Our goal was to establish whether the FAST1.2 protocol, which combines the FAST1 protocol with 3D-T2 DRIVE images, could identify the pituitary stalk (PS) and the regional anatomy more accurately. Methods: A retrospective study of 36 individuals with EPP and hypopituitarism and a control group of 78 individuals with eutopic posterior pituitary was conducted. All individuals were submitted to FAST1.2. The position and size of the pituitary lobes were described, and the presence/absence of the PS was confirmed. Results: FAST1 identified the PS in 19% of individuals with EPP, while FAST1.2 identified the PS in 67% (p < 0.001). In the FAST1.2 protocol, the PS was visible in all control individuals. All EPP patients with isolated GHD had visible PS in FAST1.2, while only 58.6% of MPHD cases had visible PS. The size of the anterior lobe and the anteroposterior length of the posterior pituitary were smaller in the EPP group versus controls (p < 0.001). We noticed a reduced anterior pituitary lobe in both diameters in MPHD patients (p < 0.05). Six patients acquired new pituitary hormone deficiencies not recognized at the time of MRI; in this group, only 1 patient had a PS not visible in FAST1.2. Discussion/Conclusion: The FAST1.2 protocol could prevent the misdiagnosis of idiopathic GHD in patients with short stature and could also be important in the progression to MPHD. The PS could be considered a predictor of hypopituitarism, but its use as an isolated indicator for the progression to MPHD is not recommended. Our results reinforce the use of the size of the anterior lobe as a predictor of hypopituitarism and a possible predictor of the degree of pituitary insufficiency. The FAST1.2 protocol could be used as an alternative to gadolinium administration, as a cheaper and faster method, while eliminating the potential risks associated with the administration of contrast media.
Acquired Factor V Deficiency: A New Cause of Bleeding in Patients with Chronic Myeloid Leukemia and Extreme Leukocytosis
Authors: To An Quoc , Ciurea Stefan O. , Kongtim Piyanuch
Published: May 2022

Bleeding complications in patients with myeloproliferative neoplasms are known to be related to acquired von Willebrand disease or platelet dysfunction. Here, we describe two very similar cases of chronic phase chronic myeloid leukemia with extreme leukocytosis (>500,000/mcL) and deep tissue bleeding after a minor trauma, who had increased PT and PTT, normal VWF antigen and activity. The patients were found to have acquired factor V deficiency. Factor V deficiency as a cause of bleeding in patients with uncontrolled chronic myeloid leukemia has not yet been reported. Bleeding resolved after correction of hyperleukocytosis, and FV level improved. We conclude that acquired FV deficiency is possible in patients with uncontrolled chronic myeloid leukemia and extreme leukocytosis.
The Role of High Intensity Focused Ultrasound in the Treatment of Fibroadenomas: A Systematic Review
Authors: Gonnah Ahmed R. , Masoud Omar , AbdelWahab Mohamed , ElMosalamy Ahmed , Al-Naseem Abdulrahman
Published: May 2022

Introduction: Fibroadenomas are solid, mobile, and non-tender benign breast lumps, with highest prevalence amongst young women aged between 15 and 35. Symptoms can include discomfort, and they can become problematic, particularly when they enlarge, resulting in many referrals for biopsies, with fibroadenomas accounting for 30–75% of the cases. Diagnosis is based on triple assessment that involves a clinical examination, ultrasound imaging, and mammography, as well as core needle biopsies. Current management includes observation for 6–12 months, with the indication of definitive surgery, in cases that are older than 35 years or with fibroadenoma persistence. Serious adverse effects of surgery might include nipple areolar distortion, scarring, and damage to the breast tissue, as well as the risks associated with surgery and anesthesia, making it a non-feasible option. Methods: A literature search was performed on the databases Embase, MEDLINE/PubMed, Google Scholar, and Ovid for English language papers published between January 1, 2000, and March 17, 2021. A structured protocol was employed to devise a comprehensive search strategy with keywords and Boolean operators defined by the research question. The keywords used for the search were “HIFU”, “High Intensity Focused Ultrasound,” “Fibroadenoma,” “Breast,” “Lesion.” This review was carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: Recently, a thermal ablative technique, high intensity focused ultrasound (HIFU), was found to be a safe, noninvasive, and technically successful alternative, having displayed promising outcomes in reducing the volume of fibroadenomas, pain experienced by patients, and the length of hospitalization. Quality of life improvement was also evidenced, exhibited by the disappearance of symptoms, and enhanced physical activity post-intervention, in addition to patients’ satisfaction with the cosmetic results and future recommendation of the procedure to other patients. Conclusion: Overall, HIFU is a well-tolerated treatment associated, with low risk of complications, that can potentially include erythema, skin discoloration, and bruising with the majority of these self-resolving shortly after the procedure.
Coronary Artery Revascularization in Heart Transplant Patients: A Systematic Review and Meta-Analysis
Authors: EL-Andari Ryaan , Bozso Sabin J. , Fialka Nicholas M. , Kang Jimmy J.H. , MacArthur Roderick G.G. , Meyer Steven R. , Freed Darren H. , Nagendran Jeevan
Published: May 2022

Background: Cardiac allograft vasculopathy (CAV) is the primary cause of late mortality after heart transplantation. We look to provide a comprehensive review of contemporary revascularization strategies in CAV. Methods: PubMed and Web of Science were systematically searched by 3 authors. 1,870 articles were initially screened and 24 were included in this review. Results: PCI is the main revascularization technique utilized in CAV. The pooled estimates for restenosis significantly favored DES over BMS (OR 4.26; 95% CI: 2.54–7.13; p < 0.00001; I2 = 4%). There were insufficient data to quantitatively compare mortality following DES versus BMS. There was no difference in short-term mortality between CABG and PCI. In-hospital mortality was 0.0% for CABG and ranged from 0.0 to 8.34% for PCI. One-year mortality was 8.0% for CABG and 5.0–25.0% for PCI. CABG had a potential advantage at 5 years. Five-year mortality was 17.0% for CABG and ranged from 14 to 40.4% following PCI. Select measures of postoperative morbidity trended toward superior outcomes for CABG. Conclusion: In CAV, PCI is the primary revascularization strategy utilized, with DES exhibiting superiority to BMS regarding postoperative morbidity. Further investigation into outcomes following CABG in CAV is required to conclusively elucidate the superior management strategy in CAV.
Metaheuristic nature-inspired algorithms for reservoir optimization operation: a systematic literature review
Authors: Ibrahim Nor Shuhada , Yahya Nafrizuan Mat , Mohamed Saiful Bahri
Published: May 2022

The purpose of this systematic literature review (SLR) article is to discuss the findings of the state-of-art metaheuristic nature-inspired algorithm (MHNIA) in reservoir optimization operation. The rationale of this approach is to elucidate the optimal way as decision making that implemented MHNIA for several complex problems in reservoir optimization operation. Commonly, the metaheuristic optimization algorithm has always been used in hydrology field, especially in reservoir optimization. Hence, this presented study reviewed a considerable amount from the previous studies of commonly nature-based optimization algorithms applied in reservoir operations. Hence, preferred reporting items for systematic review and meta-analyses (PRISMA) has been used as guidance. The source was utilized from two primary journal databases: Scopus and web of science. According to the proposed search string, the findings managed to express into nine main themes which are optimize in water release, optimize reservoir operation problems, optimize hydropower operation, optimize condensate fluids in reservoir storage, optimize water pumped storage, optimize water quality control, optimize system performance operation, optimize water demand and optimize reservoir control as flood preventing. Overall, 24 articles that passed the minimum quality were retrieved using systematic searching strategies.
Medicine prediction based on doctor’s degree: a data mining approach
Authors: Arman Md Shohel , Sarker Kaushik , Shakir Asif Khan , Hossain Shah Fahad , Hasan Afia
Published: May 2022

The effective use of information mining in profoundly unmistakable fields like e-business, promoting and retail has prompted its application in different enterprises. There is an absence of powerful investigation devices to find concealed connections and patterns in information. This examination paper expects to give a review of ebb and flow systems of learning revelation in databases utilizing information mining strategies that are being used in today’s therapeutic research especially in medicine prediction. Correlation, Chi-square and Euclidean distance feature selections are used to select features and showing the comparison of the result between K-Nearest neighbors, Naïve Bayes, decision tree, artificial neural network. The result uncovers that decision tree beats and sometime Bayesian grouping is having comparative precision as of choice tree. The analysis of performance can be done in such as doctor’s degrees may vary the diseases medicine.
Comparison of DC-DC converters for solar power conversion system
Authors: Mishra Debani Prasad , Senapati Rudranarayan , Salkuti Surender Reddy
Published: May 2022

This paper covers the comparison between four different DC-DC converters for solar power conversion. The four converters are buck converter, buck-boost converter, boost converter, and noninverting buck-boost converter. An MPPT algorithm is designed to calculate battery voltage, current of PV array, the voltage of PV array, power of PV array, output power. It is observed that the non-inverting buck-boost converter is the finest converter for solar power conversion. The final circuit design has the results of 12.2V battery voltage, 0.31A current of PV array, 34V voltage of PV array, 23mW power of PV panel, and 21.8mW of output power. The efficiency of this system is nearly 95%. All four circuits are simulated in MATLAB/Simulink R2020b.
A compact miniaturized star fractal antenna for modern wireless applications
Authors: Nejdi Ibrahime Hassan , Fatimi Aziz El , Rhazi Youssef , Lafkih Mustapha Ait , Bri Seddik , Kumar A. V. Senthil
Published: May 2022

In this paper, six-band resonant fractal antenna architecture is proposed and fabricated. The ultimate shape is established after six iterations. The resonator is starshaped, and each iteration, a hexadecagon shape from the resonator is subtracted. The antenna is designed and calculated by the numerical simulation based on the finite element method (ANSYS HFSS) and finite integration technique (CST studio). The experimental measurements were performed by the vector network analyzer AVR ROHDE AND SCHWARZ ZVB20. The gain is 4.85 dB, and the bandwidth is 0.33 GHz. The antenna’s structure allows it to work effectively in the GSM, DCS, LTE, WiMAX, WLAN, and C bands. The designed patch has a compact size of (75×75×1.6) mm3 uses as a support the FR-4 substrate for wireless equipment.
Optimizing irrigation for boosting gynura procumbens growth in Malaysia urban area
Authors: Salim Nooryani Abdul , Hanafi Marsyita , Shafie Siti Mariam , Mashohor Syamsiah , Hashim Norhashila
Published: May 2022

Growing herbs traditionally could not meet the increasing demand for high medicinal value herbs in the pharmaceutical industry and domestic market. One of the solutions is by growing herbs using vertical structures in urban areas. Even so, the amount of water needed to optimise the growth of Asian local perennial herbs in vertical structures is yet to be explored. Hence, this paper investigated the performance of a fuzzy based irrigation method in optimising irrigation for boosting the local perennial herb growth. The understudy local perennial herb is Gynura Procumbens. The decision-making for irrigation relies on the data given by soil moisture, temperature, and humidity sensors. The performance of the proposed system is compared with a timer-based system, in terms of plant growth rates, given by average leaves diameter, height, and plant crown of local perennial herbs. The results have shown that the proposed intelligent irrigation system has reduced water consumption by 16.93% and the average plant growth rate has increased by at least 1.5% and to a maximum rate of 76.64%.
A model for blockchain-based privacy-preserving for big data users on the internet of thing
Authors: Alsammak Ihab L. Hussein , Alomari Mohammed F. , Shakir Nasir Intedhar , Itwee Wasan H.
Published: May 2022

Recently, with the emergence and growth of the IoT as a promising vehicle for sustainable development, the concept of ‘smart cities’ has advanced significantly. However, many challenges inhibit the development of using IoT applications in smart cities, such as issues of privacy, scalability, trust, security, and centralisation. On a daily basis in smart cities, the IoT generates a large amount of data (big data) which could potentially be used for questionable or suspect purposes by attackers. The weight of the security issues surrounding big data must be acknowledged as the associated technology is continuously developing. To solve this issue, a strategy that secures important and potentially sensitive user information on a distributed blockchain and transmits non-sensitive information to the primary system by controlling the size of the blockchain is proposed. This solution cannot be achieved in traditional blockchain because it requires too many resources. The model is composed of three proposed algorithms: the first aims to allocate data to each user; the second performs the process of searching for data, and the third confirms the communication process. Experiments have proved that this proposed protocol for blockchain has excellent byzantine fault tolerance. The final experimental results of the proposed model established that the algorithms effectively meet the performance requirements.
A maldição da tolerância e a arte do respeito nos encontros de saberes - 1a. Parte
Authors: Barbosa Neto Edgar Rodrigues , Goldman Marcio
Published: May 2022

A partir de uma retomada analítica da noção de respeito tal qual aparece principalmente nas religiões de matriz africana e em outros coletivos afroindígenas, este artigo pretende mostrar não apenas a centralidade dessa noção para as práticas vinculadas a essas tradições, como, a partir daí, conectar a noção com a própria prática da antropologia. Por meio de uma cuidadosa justaposição entre filósofos, escritores, pensadores indígenas, afroindígenas, quilombolas e afro-brasileiros, especula-se, assim, a possibilidade de uma relação mais respeitosa com outras práticas de conhecimento, capaz de contribuir para uma renovação das nossas. A experiência dos chamados encontros de saberes funciona, nesse sentido, como um meio a partir do qual se tenta pensar essas questões de modo a estabelecer uma relação transversal com as práticas com as quais se busca dialogar. Ou seja, uma relação definida pelo mais absoluto respeito diante das fronteiras que temos que cruzar para estabelecer esse diálogo, e pela vergonha diante de qualquer possibilidade de assimilar ou destruir aquilo com o que se pretende estabelecer uma relação.
Productive and reproductive performance of crossbred dairy heifers with induced lactation and efficacy of antimicrobial therapy associated with internal teat sealants
Authors: Monteiro Camylla Pedrosa , Mingoti Rodolfo , Alves Bruna Gomes , Barcelos Melina Melo , Freu Gustavo , Martins Cristian Marlon de Magalhães Rodrigues , Baruselli Pietro Sampaio , Santos Marcos Veiga dos
Published: May 2022

This study evaluated (a) the efficacy of an association between injectable antibiotic therapy and sealant (ATBS) on milk yield (MY), somatic cell count (SCC), and prevalence of intramammary infections (IMI); and (b) the efficacy of gonadotropin-releasing hormone (GnRH) on follicular cyst (FCs) resolution (cyclicity at the 45th day in milk; DIM) and cumulative pregnancy rate (CPR) in heifers submitted to a lactation induction protocol (LIP). A total of 114 crossbred (Holstein × Jersey) heifers, with 34.7 ± 4.8 months and 439 ± 56.35 kg were submitted to LIP. On the 5th day of the LIP, the heifers were assigned to (i) ATBS (n = 57) with 7 mg/kg of norfloxacin associated with sealant and (ii) Control 1 (n = 57; CONT1) with no treatments. Lactation began on the 21st day of LIP and the 15th DIM, FCs were diagnosed and 106 heifers were randomized into two treatment groups with 53 heifers each: (i) GnRH (5 mL injectable GnRH) and (ii) Control 2 (CONT2; no treatment). Of the 114 heifers initially induced, 83.33% (n = 95) responded to LIP with an average MY of 15.19 kg/milk/day during 22 weeks of lactation. In the first 14 DIM, the IMI prevalence was 18% and 28% for heifers ATBS and CONT1 treated, respectively. Additionally, coagulase-negative Staphylococcus was the most frequently isolated group of pathogens. Mammary quarters that received ATBS treatment had a lower risk of IMI and SCC than CONT1. The cyclicity at 45 DIM was 68% (ATBS) and 35% (CONT1), and 57% and 46% for animals in the GnRH and CONT2. CPR was 60% in the ATBS group and 89% in CONT1, but GnRH treatment did not affect the CPR. In conclusion, LIP was effective in stimulating MY in heifers, and the IMI prevalence decreased with ATBS treatment. Also, the use of GnRH did not affect the FC regression, cyclicity at 45 DIM, and CPR.
Brasis sobrepostos: fontes da conformação e transformação do tempo
Authors: Gouveia Inês , Galvão Luciana Suarez , Garcia Walter
Published: May 2022

Editorial - O ano de 2022 parece nos convidar para o olho do furacão, com todo o seu caráter celebrativo em torno de efemérides que atualizam e associam 1822, 1922 e 2022. É importante termos atenção, pois, conforme Jacques Le Goff (1990) argumenta, as celebrações têm sido apanágio dos conservadores. Nesses termos, compreendemos que o passado tem sido um tempo decorrido e inerte, o presente, fugaz, e o futuro, um tempo abstrato, ancorado em devir de esperança, progresso,  desenvolvimento e revolução. [...]
Quem arrisca perde e ganha: um estudo sobre O sedutor do sertão, de Ariano Suassuna
Authors: Oliveira Fábio José Santos de
Published: May 2022

Este artigo tem por objetivo analisar um romance de Ariano Suassuna (1927-2014) publicado postumamente: O sedutor do sertão (2020). Apesar de seu aspecto deleitável (o que poderia gerar a impressão de uma escrita facilitada), O sedutor do sertão se mostra uma obra de ampla complexidade compositiva. Fatos históricos da Paraíba, motivos populares, citação de folhetos de  cordel e aproveitamento cromático, tudo isso se concentra na elaboração de uma obra rica em detalhes, bem ao estilo de Ariano Suassuna.
Necropolítica e crítica interseccional ao capacitismo: um estudo comparativo da convenção dos direitos das pessoas com deficiência e do estatuto das pessoas com deficiência
Authors: Santos Sérgio Coutinho dos , Kabengele Daniela do Carmo , Monteiro Lorena Madruga
Published: May 2022

As teses interseccionais agregam, entre outras condições, raça, gênero e classe como formas de opressão. Mais recentemente, surgiram reflexões anticapacitistas interseccionais, assim denominadas por incorporar a opressão contra pessoas com deficiência à interseccionalidade. O objetivo do artigo é sistematizar em termos jurídicos e políticos a relevância desta expansão epistêmica. Para isto, será analisado o conceito social de racismo com base em Achille Mbembe como elemento constitutivo de discriminações múltiplas. A legislação e a jurisprudência brasileiras serão mostradas como marcos normativos para a aceitação destas teses para enfrentar o racismo e o capacitismo estruturais brasileiros. Por fim, como forma de luta emancipatória para as identidades fragmentadas por formas de discriminação, foi mostrado como múltiplas teses interseccionais são formas efetivas de resistência para uma sociedade mais justa. Conclui-se que os estudos sobre a deficiência são uma dimensão necessária na perspectiva interseccional.
Hinário para corpos em desalinho I – Meninas
Authors: Becker Mar
Published: May 2022

A seção Criação tem por objetivo publicar textos e materiais inéditos de escritores e/ou artistas, fotógrafos, desenhistas, além de documentos inéditos encontrados no Arquivo do IEB-USP. “Hinário para corpos em desalinho/ I – Meninas” reúne quatro poemas de Mar Becker (Marceli Andresa Becker). Mar Becker é poeta, tem formação em Filosofia (Universidade de Passo Fundo – RS) e especialização em Metafísica e Epistemologia (Universidade Federal da Fronteira Sul – RS). Publicou A mulher submersa, seu primeiro livro (poesia), em maio de 2020, pela Editora Urutau – duas edições, uma no Brasil e outra em Por tugal (BECKER, 2020). Em 2021, A mulher submersa recebeu o Prêmio Minuano, concedido pelo estado do Rio Grande do Sul, e foi finalista do Prêmio Jabuti.
Um olhar sobre o anjo negro na metrópole
Authors: Azevedo Amailton Magno
Published: May 2022

Esta resenha tece considerações sobre a trajetória do músico e educador Salloma Salomão e suas relações familiares e sociais na cidade de São Paulo. Refletir sobre essa trajetória permitiu compreender como os excluídos sociais forjaram seus modos de vida e arte na metrópole.
Abstract 103: Smooth Muscle Cell Specific Overexpression Of Adamts7 Drives Atherosclerosis Development Through The Remodeling Of The Extracellular Matrix
Authors: Chung Allen , Chang Hyun-kyung , Soni Rajesh , Reilly Muredach P , Bauer Robert C
Published: May 2022

Genome-wide association studies in humans link ADAMTS7 with coronary artery disease. Subsequent studies in mice showed ADAMTS7 to be proatherogenic, as whole-body knockout (KO) reduced atherosclerosis independent of lipid-lowering. Further studies show that Adamts7 expression is temporarily induced in response to vascular injury, and Adamts7 KO reduces primary smooth muscle cell (SMC) migration ex vivo. However, both the mechanism through which ADAMTS7 influences atherosclerosis progression and the responsible cell type remain unclear.

As ADAMTS7 is secreted, we sought to determine its cleavage targets. We generated an immortalized human SMC line with doxycycline-inducible expression of GFP or ADAMTS7. We analyzed conditioned media from these cells via terminal amine isotopic labeling of substrates (TAILS) proteomics. This method labels new protein N termini, enabling the identification of cleavage products. Overexpression of
Adamts7
enriched extracellular matrix (ECM) peptides such as Col1a1, Col1a2, Col4a2, and fibronectin. Furthermore, KEGG analysis identified ECM receptor interaction and focal adhesion formation as highly enriched pathways in the dataset. These results suggest ADAMTS7 alters SMCs by modulating signaling between cell and ECM.

To examine the cell type that confers the proatherogenic effects of Adamts7, we generated a conditional transgenic ADAMTS7 mouse on the Ldlr knockout background. Given previously described roles for ADAMTS7 in SMC migration and vascular reendothelialization, we crossed these mice to either the Tie2-Cre or Myh11-CreERT2 to overexpress ADAMTS7 in endothelial and SMCs respectively. We found >3-fold increase (p = 0.0002) in plaque burden by en face staining in overexpression of Adamts7 in SMCs compared to controls. In contrast, transgenic overexpression of Adamts7 in endothelial cells is embryonic or perinatally lethal (Chi-squared = 0.0018).

In summary, our transgenic study affirms the proatherogenic effect of increased Adamts7 expression in SMCs in vivo. Furthermore, our TAILS data suggests a dynamic role of ADAMTS7 in cleaving ECM. These studies fill critical knowledge gaps in our understanding of ADAMTS7 biology and help inform potential therapeutic avenues to targeting this enzyme.
Abstract 112: Examining The Heterogeneity Of Primary Human Macrophages And Pharmacogenomic Networks To Identify Novel Targets For Precision Medicine For Vascular Inflammation
Authors: Decano Julius , Maiorino Enrico , Matamalas Joan T. , Chelvanambi Sarvesh , Tiemeijer Bart , D'Souza Edwin , Mukai Shin , Yanagihara Yoshihiro , Whelan Mary , Asano Takaharu , Singh Sasha A , Sharma Amitabh , Aikawa Elena , Aikawa Masanori
Published: May 2022

Background:
We hypothesize that macrophage heterogeneity is an unexploited source of therapeutic targets for vascular inflammation. Interferon-gamma (IFNγ) stimulated primary human macrophages M(IFNγ) is a widely used
in vitro
model for proinflammatory macrophages. However, typical activation-induced transcript profiling assumes a homogenous macrophage population. Our goal is to evaluate the extent of heterogeneity of activated macrophages to devise a strategy for precision medicine for inflammatory vascular disease.

Methods:
Using unbiased single-cell RNA sequencing (scRNA-seq), systems biology, and machine learning, we examined inter-subgroup differences of human primary M(IFNγ) (4 donors). Network analysis, kinetic proteomics, and
in vitro
assays (n=3-6) characterized the clusters, followed by validation in human carotid atherosclerotic plaques (n=13). scRNAseq data analysis in the L1000 CDS
2
drug-gene network computationally identified drugs that may potentiate or suppress each cluster.

Results:
The scRNA-seq demonstrated 3 distinct subpopulations: Clusters 1, 2, and 3 (C1, 2, and 3). C3 showed increased proinflammatory chemokine production, protein synthesis, and glycolysis. C1 was more efferocytotic/phagocytic, chemotactic, and less inflammatory. C2 is intermediate between C1 and C3. Histological analysis localized C1 and C3-like macrophages in different areas of the plaques (
Fig. 1A
). In addition, we used targeted scRNAseq (n=4) to analyze M(IFNγ) treated with an L1000-derived drug BI-2536 (Polo-like kinase inhibitor). As predicted, BI-2536 shifted the phenotypic heterogeneity of M(IFNγ) towards less inflammatory characteristics (
Fig. 1B
) which were further validated with bulk qPCR & ELISA (n=8).

Conclusion:
Our study presents a novel strategy for precision medicine that leverages single-cell data and gene interaction networks to identify modulators of macrophage heterogeneity as new anti-inflammatory therapies.
Abstract MP03: Histone-mediated Platelet Activation And Microvesicle-induced Thrombin Generation In COVID-19
Authors: Eustes Alicia S , Swamy Jagadish , jensen melissa , Wilson Katina M , Kudchadkar Shibani M , Perepu Usha , Miller Francis J , Lentz Steven R , Dayal Sanjana
Published: May 2022

Background:
Severe COVID-19 leads to inflammation and coagulopathy with progression to multiple organ failure. Several prothrombotic mechanisms have been proposed, including NETosis with release of citrullinated histones, platelet hyperactivation, and generation of procoagulant microvesicles.

Aims:
We hypothesized that histones derived from NETosis promote platelet activation and release of microvesicles that mechanistically contribute to thrombin generation and thrombosis in COVID-19.

Methods:
Platelet poor plasma (PPP) was prepared from 136 COVID-19 patients enrolled in a multicenter randomized clinical trial comparing standard prophylactic dose to intermediate dose enoxaparin in hospitalized patients with COVID-19 (NCT04360824). We also prepared PPP and washed platelets from 53 healthy subjects. We measured citrullinated histone H3 (H3Cit) by ELISA, microvesicles by flow cytometry, and thrombin generation using the Calibrated Automated Thrombogram.
Ex vivo
platelet adhesion and thrombus growth on collagen was measured in a microfluidic chamber.

Results:
Compared to healthy subjects, COVID-19 patients had elevated plasma levels of H3Cit and platelet-derived microvesicles. When PPP was triggered with exogenous tissue factor and phospholipids, higher endogenous thrombin potential, peak thrombin, and velocity index were observed in COVID-19 patients compared to healthy subjects. Increased thrombin generation with COVID-19 PPP was evident even when triggered without added phospholipids, suggesting the presence of procoagulant microvesicles in COVID-19 plasma. Enhanced thrombin generation also was observed after transfer of microvesicles isolated from COVID-19 patient plasma to control PPP. Incubation of control platelets with PPP from COVID-19 patients but not healthy subjects caused increased platelet-dependent thrombin generation and larger platelet-thrombi under venous shear stress. These effects of COVID-19 plasma on platelet-dependent thrombin generation and platelet-thrombi formation were inhibited by a histone aptamer.

Conclusions:
We conclude that histone-mediated platelet activation promotes thrombosis in COVID-19 in part via increased thrombin generation driven by microvesicles.