bluuebunny/crossref_metadata_2025 huggingface dataset:
ZC3H12D upregulation in head and neck squamous cell carcinoma: a potential prognostic biomarker associated with immune infiltration
Authors: Zhao Mingyu , Huang Wenkai , Huang Xu , Gu Feihan , Yang Lin , Wang Yuanyin , Chen Ran
Published: February 2025

Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor that poses a major hazard to people's health. ZC3H12D, which belongs to the family of CCCH-type zinc finger-containing proteins, is a negative regulator with a key function in immune modulation. However, it is still unclear how ZC3H12D affects the immune infiltration and prognosis of HNSCC. In this study, the data obtained from various databases were used to assess ZC3H12D expression in HNSCC and in various tumors under the HNSCC classification. The association between clinical features and ZC3H12D expression in HNSCC was evaluated using the UALCAN database. Additionally, a ROC curve was employed to analyze the diagnostic value of ZC3H12D. The effect of ZC3H12D on prognosis was assessed using Kaplan-Meier curves, Cox analysis, and the nomogram model. Gene Set Enrichment Analysis, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were employed to investigate the underlying role of ZC3H12D in HNSCC. The association between ZC3H12D expression and the tumor microenvironment and immune checkpoints were investigated by TIMER2 and Tumor Immune Single Cell Hub 2 databases and various packages in R. The findings demonstrated a significant up-regulation of ZC3H12D expression in HNSCC, while ZC3H12D expression was found to be associated with clinical parameters. Our study also demonstrated that ZC3H12D could act as a potential prognostic biomarker for HNSCC, especially oral squamous cell carcinoma. Additional analyses have shown that ZC3H12D was associated with common immune checkpoint genes and may be related to immune infiltration in HNSCC.
Gastrodin plays a protective role in alleviating hepatic ischemia reperfusion injury by regulating heme oxygenase-1 expression
Authors: He Shan-Shan , Huang Han-Fei , Shi Shao-Qing , Zhao Jing-Jiao , Yuan Bo , Ji Xiang , Zhang Hong-Bin
Published: February 2025

Hepatic ischemia reperfusion injury (HIRI) is a pathophysiological and complex systemic process involving multiple tissues and organs. Gastrodin (GSTD), a natural compound from Gastrodia elata, displays a variety of interesting pharmacological activities. Heme oxygenase-1 (HO-1), a stress-responsive protein, has a cytoprotective defense response against oxidative and inflammatory injuries. The aim of this investigation was to elucidate whether GSTD plays a protective role against HIRI by regulating HO-1 expression. GSTD (100 mg/kg) or zinc protoporphyrin (15 mg/kg; an HO-1 inhibitor) was administered to HIRI C57 male mice. GSTD decreased glutamic pyruvic transaminase and glutamic oxaloacetic transaminase levels in HIRI mice. Inflammatory (TNF-α and IL-6) and oxidative-stress (malondialdehyde, MDA) markers of HIRI mice were decreased by GSTD. GSTD up-regulated HO-1 protein and mRNA expression in HIRI mice but decreased caspase-3 and -9 protein expression. GSTD lowered mRNA expression of apoptosis-related genes (caspase-3, -9, -12, and Bax) in the liver of HIRI mice but enhanced mRNA level of the anti-apoptotic Bcl-2 gene. Consistent with in vivo results, GSTD displayed a similar regulatory effect on the expression of mRNA (HO-1, caspase-3, -9, -12, Bax, and Bcl-2) and protein (HO-1, caspase-3 and -9) as well as inflammatory (TNF-α and IL-6) and on oxidative stress factors (superoxide dismutase and MDA) in BRL-3A cells transfected with small interfering HO-1 RNA in a hypoxia-reperfusion model. In conclusion, GSTD up-regulated HO-1 expression to play a protective role in HIRI by anti-apoptotic, anti-inflammatory, and antioxidant effects. GSTD is a promising natural compound that alleviated HIRI in liver surgery.
Interaction between saflufenacil and ammonium glufosinate to control ryegrass
Authors: Avila-Neto R. , Ulguim A. R. , Schneider T. , Fortuna C. , Holkem A. S. , Somavilla I. P.
Published: February 2025

Abstract Annual ryegrass (Lolium multiflorum Lam.) is one of the main weeds in subtropical cropping systems of Europe, Oceania and South America. Therefore, the hypothesis of this work is that the interaction between ammonium glufosinate and saflufenacil can be synergistic for ryegrass control. Our main goal was to evaluate the effects of the mixture of saflufenacil with ammonium glufosinate in the control of ryegrass by graphical analysis of isobologram and a surface response graphic in addition to the Colby’s test. Two experiments were carried out, in greenhouse (isobolograma experiment) and field conditions (Surface response and Colby). The behavior of the mixture between saflufenacil and ammonium glufosinate was a synergistic interaction for the control of ryegrass by the isobologram test on the dry matter variable . By the Colby test, it was confirmed that at the dose of 400 g ha-1 of ammonium glufosinate and at the doses of 10.5, 21.0 and 31.5 of saflufenacil the effect was synergistic for control of ryegrass for as control variables (%).The mixture between these two herbicides has synergistic potential to increase ryegrass control, mainly with a high proportion of ammonium glufosinato over saflufenacil.
Há espaço para propostas pós-desenvolvimentistas na esquerda partidária brasileira?1
Authors: Todt Marcos Leite De Matos , Madeira Rafael Machado
Published: February 2025

Qual é o espaço existente para ideias pós-desenvolvimentistas e baseadas na sustentabilidade forte nos programas de governo apresentados por candidaturas de esquerda no Brasil contemporaneamente? Com base nessa questão, analisamos as propostas dos partidos de esquerda que apresentaram candidaturas próprias na eleição presidencial de 2018 e entrevistamos filiados a esses partidos. As evidências apontam que, com exceção parcial do Partido Socialismo e Liberdade (PSOL), a esquerda partidária brasileira se limita a pensar alternativas dentro do paradigma desenvolvimentista. Embora o programa do PSOL, em 2018, tenha enfoque desenvolvimentista, a parte dedicada ao meio ambiente contém propostas referenciadas no debate internacional sobre alternativas ao desenvolvimento, o que indica que, nesse partido, a sustentabilidade forte tem condições de (ao menos) disputar espaço com o desenvolvimentismo.
Difusão e operação dos conselhos municipais nos estados: regimes de normatização e seus efeitos
Authors: Lavalle Adrian Gurza , Guicheney Hellen , Bezerra Carla de Paiva
Published: February 2025

Argumentamos que regimes de normatização estadual ampliam a presença territorial e fortalecem a operação dos conselhos gestores de políticas nos municípios sob sua jurisdição. Examinam-se três áreas de políticas que correspondem a tipos de conselhos com padrões de difusão territorial e produção de decisões conhecidos e relacionados à regulação federal: Patrimônio, Meio Ambiente e Assistência Social. Os resultados de regressões por área confirmam as hipóteses: os efeitos esperados dos regimes ocorrem e o fazem com maior intensidade em conselhos pouco regulados pela União. Porém, também sugerem que tal relação é mais acurada para os conselhos sob baixa e alta regulação federal, a qual perde força para aqueles em posição intermediária. Nesses casos, fatores locais dos municípios relativos ao porte, às pressões sociais ou às capacidades técnico-administrativas também ganham relevância.
Prevalence of clinical signs and diagnosis of temporomandibular disorders in adults with intellectual disability
Authors: PUPO Yasmine Mendes , REIS Giselle Emilãine da Silva , DEZANETTI Jullyana Mayara Preizner , FANDERUFF Marina , SCHOSSLER Thábata Louise , PETTERLE Ricardo Rasmussen , CAVALHEIRO Amanda Kerin Alves , BONOTTO Daniel , TORRES-PEREIRA Cassius Carvalho , HILGENBERG-SYDNEY Priscila Brenner
Published: February 2025

Abstract Introduction Temporomandibular Pain among individuals with intellectual disabilities has been explored in only a few studies. Nevertheless, it is noted that pain in this population often remains undetected and inadequately treated. Objective To evaluate and compare, signs and diagnosis of temporomandibular disfunction (TMD) in adults with and without intellectual disability (ID). Material and method A cross-sectional study with comparison group was conducted. Data regarding gender and age of ID group were collected from medical records available in the institutions of special education. These data from the comparison group were collected in the dental clinics of the Federal University of Parana (UFPR). We using the RDC/TMD I axis, with the help of the UPAT. The clinical examination evaluated muscle and joint pain, mouth opening pattern, extension of mandibular movement and joint noise. The Chi-squared test, Fisher's test, and Bonferroni's post-test were used with significance level of 5%. Result Two homogeneous groups by gender (P = 0.08) and age (P = 0.419) were evaluated, of which 97 adults with intellectual disability and another 96 did not have intellectual disability. No significant difference was observed between groups on TMD signs (p>0.05). The comparison group had significantly more disc displacement with reduction (DDWR) (P=0.011). When we compare the differences with respect to gender. Overall, women in the comparison group had higher prevalence for TMD diagnoses (p<0.05), but these differences were not found in the ID group (p>0.05). Regarding age, only the comparison group showed statistical significance, with the diagnosis of myofascial pain with limited opening being more diagnosed in young individuals (p=0.009). Conclusion Adults with ID have similar prevalence of TMD signs and symptoms to adults without ID. Gender differences are not significant in the ID group.
Autorregulação da aprendizagem no contexto da matemática no ensino médio: uma revisão sistemática
Authors: Silva Francini Damiani e , Pinheiro Nilcéia Aparecida Maciel , Semensato Michel Teston , Pilatti Luiz Alberto
Published: February 2025

Resumo Esta revisão sistemática teve como propósito analisar os estudos sobre a autorregulação da aprendizagem (ARA) no ensino médio, especialmente em relação à disciplina de matemática. A abordagem metodológica foi guiada pelas diretrizes recomendadas no protocolo PRISMA. Os critérios de inclusão consideraram a população (alunos do ensino médio), o contexto (matemática) e o conceito (ARA), sem restrições de período ou idioma. Um total de 33 estudos, datando de 1996 a 2023, foram incorporados. Desses, nove investigaram intervenções visando promover a ARA entre os estudantes. Os resultados dessas intervenções respaldaram a eficácia das mesmas tanto na promoção da ARA em matemática quanto na melhoria do desempenho escolar na disciplina. Os demais estudos, de maneira geral, focaram em analisar as dimensões da ARA em relação à aprendizagem dos alunos na disciplina de matemática. Os resultados destacaram a importância dos fatores motivacionais e da adoção de variadas estratégias de aprendizagem como preditores positivos do desempenho acadêmico. A ausência de pesquisas brasileiras identificadas sugere a necessidade de futuras investigações sobre ARA no contexto da matemática no ensino médio no Brasil. As limitações e recomendações para pesquisas subsequentes são abordadas ao final desta revisão.
Uma Análise de Introduções de Livros de Pré-Cálculo: Perspectivas e Intencionalidades
Authors: Batistela Rosemeire de Fatima , Santos Marli Regina dos
Published: February 2025

Resumo Neste artigo, voltamo-nos para as Introduções de livros de Pré-Cálculo visando compreender o que é exposto por seus autores ao apresentarem a obra ao seu público-alvo. Por meio de uma análise fenomenológica das Introduções desses livros, buscamos evidenciar motivos para elaboração da obra, os objetivos que se destacam, os conteúdos que os autores julgam subsidiários às disciplinas de Cálculo Diferencial e Integral, bem como argumentações e concepções de ensino explicitadas por eles. Evidenciam-se, na análise, a importância do Pré-Cálculo no enfrentamento à reprovação e evasão nos cursos de exatas e a busca de alinhamento entre a matemática da Educação Básica e aquela necessária ao Cálculo.
Inteligencia artificial: desafíos éticos y futuros
Authors: Leonel Jhadson Silva , Leonel Camila Ferreira Silva , Byk Jonas , Furtado Silvania da Conceição
Published: February 2025

Resumen Esta revisión narrativa de la literatura aborda la evolución y la aplicación de la inteligencia artificial en la salud, con énfasis en avances como la interpretación de imágenes para diagnósticos y el uso de robots en hospitales. Se discuten cuestiones éticas, incluida la privacidad de los datos y el sesgo algorítmico, enfatizando los principios éticos y las regulaciones, como la Ley General de Protección de Datos, en Brasil. Se ejemplifica el desafío del sesgo, resaltando la necesidad de eliminar la discriminación en los sistemas, y se aborda la complejidad de la responsabilidad y la transparencia en la medicina, centrándose en la importancia de comprender los algoritmos para evitar errores médicos. Se destaca la relevancia del debate acerca del potencial positivo de la inteligencia artificial, reforzando que es necesario enfrentar dilemas éticos para asegurar el uso ético y responsable de la tecnología en el futuro.
A abolição revista por Zózimo Bulbul no cinema: aspectos da resistência negra entre a arte e a história
Authors: Lecci Alice Carvalho Lino
Published: February 2025

RESUMO Neste artigo, dirige-se uma crítica a determinados relatos constituintes do documentário Abolição (1988), de Zózimo Bulbul, que discorrem sobre as revoltas no período escravocrata, a abolição e o posicionamento do Estado após a emancipação, a fim de enfatizar suas dimensões históricas e políticas. Para tanto, tais depoimentos, majoritariamente de pesquisadores/as e militantes negros/as, foram cotejados com as perspectivas enunciadas no campo da História, da Antropologia e da Filosofia por Lélia Gonzalez, Beatriz Nascimento, Ynaê dos Santos, Kabengele Munanga e Molefi Kete Asante. Nessa obra, o/a negro/a apresenta-se como enunciador/a da própria história ao denunciar as injustiças acerca da barbárie escravocrata e racista, ao mesmo tempo em que reivindica equidade em sociedade. A narrativa áudio-imagética se alinha à certa historiografia erigida sobre a população negra do Brasil.
Favelas e as pós-vidas da cidade escrava
Authors: Fischer Brodwyn
Published: February 2025

RESUMO Este artigo examina as representações visuais da urbanidade negra do século XIX ao início do século XX. Considera-se como a urbanidade negra foi vivida, imaginada e visualizada nas cidades do século XIX, enfocando a tensa interdependência entre a cidade escrava (a cidade estruturada pela prática da escravidão) e a cidade negra (a cidade criada por e para os negros). Em seguida, analisa como os fotógrafos municipais representaram as favelas e os mocambos do século XX por meio dos regimes visuais da cidade escrava. Conclui-se que, a despeito de tais representações, o urbanismo informal constituiu sua própria prática visual, permitindo que os afrodescendentes inscrevessem a cidade negra de forma definitiva na tela urbana.
Factors associated with maternal fatigue and perceived self-efficacy for breastfeeding in women and transgender men
Authors: Lima Lorena Maria Santana , Campos Samara Kauany Rodrigues , Silva Kelly da , Guedes-Granzotti Raphaela Barroso , César Carla Patrícia Hernandez Alves Ribeiro
Published: February 2025

ABSTRACT Purpose To evaluate the perception of fatigue and self-efficacy for breastfeeding in women and transgender men. Methods The survey was conducted virtually, and the participants completed the Severity of Fatigue and Self-Efficacy of Breastfeeding Scales – Short Version”, and questions about sociocultural and demographic data, after signing the informed consent form. The results were analyzed by the Chi-square Test, with a significance of 5%. Values greater than 28 points on the scale used indicated the presence of fatigue and, for self-efficacy, efficacy was classified as low (score between fourteen and 32 points. Results The sample consisted of 334 participants, aged between 18 and 43 years (mean: 31.74 ± 5.29). Most residents were from the northeast, and southeast of Brazil and declared having a higher education, with a complete postgraduate degree (n=182, 54.49%). Regarding maternal fatigue during breastfeeding, most of the sample shows fatigue (n=314; 94.01%). The results that revealed statistically significant differences were: schooling (p=0.002), help with the baby (p=0.013), if you stopped receiving help because of the contagion of Covid-19 (p=0.003), the number of prenatal consultations (p=0.025) and type of delivery (p<0.001). As for the results related to self-efficacy for breastfeeding, most obtained an average rating, with some variables having an impact on this perception, such as offering a bottle (p=0.018), self-efficacy paired with schooling and monthly income (p<0.001), and if stopped receiving help with the baby for fear of contagion and diagnosis of Covid-19 (p=0.018). Conclusion High-intensity fatigue and the perception of self-efficacy average, highlight the need for intervention as soon as possible, in order to improve maternal mental health during breastfeeding and avoid early weaning.
The dentist ‘without high-speed instruments’: Oral health care in the SUS during the COVID-19 pandemic
Authors: Tofani Luís Fernando Nogueira , Bigal André Luiz , Tureck Fernando , Andreazza Rosemarie , Chioro Arthur
Published: February 2025

ABSTRACT This study analyzes how the COVID-19 pandemic context affected oral health care in the Unified Health System (SUS) in the state of São Paulo. It was carried out in two stages: an online structured questionnaire aimed at municipal health secretaries and open interviews with 33 managers, 19 health service coordinators, and 7 SUS workers, in two Health Regions. The results are presented and discussed in three moments-suspension of activities, reconfiguration of the dentist’s work during the pandemic, process of resuming care-and analyzed according to the concepts of collective oral health, bucallity, health care, health work process, interprofissionality, amplified clinic, comprehensive health care, and instituted-instituting process. The pandemic context emerges as an analytical moment for reorienting oral health care practices and allows us to reflect on the need to expand the clinic and the work of dental surgeons beyond the office and dental procedures.
Escutando histórias para construir estratégias de educação permanente em saúde materno-infantil em Alagoas
Authors: Allebrandt Débora , Junqueira Telma Low Silva , Meinerz Nádia , Amorim Vivyan
Published: February 2025

Resumo A saúde materno-infantil configura um subsetor da gestão pública que é responsável por indicadores de desenvolvimento social e humano, tais como as taxas de fecundidade, de mortalidade infantil e de mortalidade materna. Neste artigo, dialogamos sobre informações oriundas do primeiro desfecho de uma pesquisa qualitativa com trabalhadoras de saúde que atuam no Sistema Único de Saúde (SUS), nos cenários da atenção primária e terciária no estado de Alagoas. Convidamos essas sujeitas para estarem como parceiras na identificação de desafios e potencialidades que marcam seus cotidianos profissionais a fim de construirmos estratégias de educação permanente em saúde que possibilitem a aproximação entre a divulgação científica e o exercício de uma prática interprofissional e humanizada em saúde materno-infantil. Refletimos aqui sobre dois aspectos que nos inquietaram nas histórias que escutamos: a educação permanente focada na educação continuada e os desafios frente a práticas de racismo cotidiano. Essas primeiras análises nos guiaram a refletir os resultados da pesquisa, fazendo-nos imaginar a construção de uma estratégia experimental que contribua com o desenvolvimento de práticas exitosas no cuidado em saúde de pessoas que vivenciam o ciclo gravídico-puerperal no nosso território.
História, Caminho e Horizonte: a Análise do Discurso Crítica Latino-americana como referencial de pesquisa e para pesquisar
Authors: Aparecido de Faria Mateus , Pereira de Souza Lívia , Dias Bevilacqua Paula
Published: February 2025

Este artigo explora a Análise do Discurso Crítica Latino-Americana (ADC-LA), destacando-a como um referencial metodológico contra-hegemônico para pesquisas sobre discursos. Partindo da Teoria Social do Discurso de Fairclough e de seus desdobramentos, o estudo apresenta uma perspectiva decolonial centrada na América Latina, abordando as colonialidades do poder, saber e ser que permeiam as práticas discursivas. A ADC-LA é proposta como uma ferramenta de transformação social, integrando conceitos como aquilombagem crítica e epistemes afroperspectivistas. Ao exemplificar sua aplicação em contextos acadêmicos e sociais, o artigo argumenta pela relevância de epistemologias plurais para superar a dependência de teorias eurocentradas. Com isso, a ADC-LA é concebida como um caminho para desconstruir hierarquias de saber e fomentar análises mais inclusivas, alinhadas às realidades locais e às demandas de grupos historicamente subalternizados.
Deficiencias del Sistema de Responsabilidad Penal para Adolescentes en el municipio de Ocaña, Norte de Santander
Authors: Carmona-Gómez Elsibed , Jaime-Jaime Lizbeth , Carrascal-Vergel Ana María
Published: February 2025

El presente artículo examina la delincuencia juvenil y pretende dar a conocer las deficiencias del Sistema de Responsabilidad Penal para Adolescentes en el municipio de Ocaña. Se realizó esta investigación de análisis mixto, bajo los métodos cualitativo y cuantitativo, mediante la revisión de documentos y estadísticas, partiendo de un estudio de campo basado en la recopilación de información proveniente de jurisprudencia y de la muestra obtenida en los expedientes de los Juzgados Promiscuos de Familia Primero y Segundo, bajo la hipótesis de que las sanciones impuestas a los adolescentes presentan fallas que evidencian las deficiencias en el logro de los objetivos previstos en La Ley 1098 de 2006. Se destacan, entre los resultados, la vulneración de los derechos de los jóvenes infractores, al no existir un CAE en la cuidad y al carecer del personal que vigile el cumplimiento de la prestación de servicios a la comunidad por parte del menor, que conlleven a permanecer cerca de su familia. Asimismo, la no aplicación por parte de los jueces de la sanción de prestación de servicios a la comunidad, no permite la inclusión de la sociedad en el proceso de resocialización, característicos de la justicia restaurativa propios del Sistema de Responsabilidad Penal para Adolescentes en el ordenamiento colombiano.
Educators and caregivers’ oral health knowledge, attitudes, and practices in special education schools in the eThekwini District, KwaZulu-Nata
Authors: Gumede Sinenhlanhla , Singh Shenuka , Radebe Mbuyiselwa
Published: February 2025

Disability often leaves individuals reliant on caregivers for care and oral hygiene, particularly the young, severely impaired and institutionalised. However, these caregivers may lack adequate knowledge on oral hygiene and proper diet, leading to unhealthy eating habits or cariogenic snacks and increasing the risk of oral diseases throughout their lifetime
“One of the Most Satisfying Parts of the Job”: The Perceived Mattering and Role Satisfaction of NCAA Faculty Athletic Representatives
Authors: Smith Allison , Robin Hardin  , Elizabeth Taylor  , Jessica Siegele  , Kelsie Saxe
Published: February 2025

The increase in research related to intercollegiate athletic coaching, athletes, and leadership continues to be of note within the sport management field. However, less is known about the position of the National Collegiate Athletic Association (NCAA) Faculty Athletic Representative (FAR) despite their important role to serve as a liaison between the academic and athletic units on their campuses. Thus, the purpose of this study was to examine NCAA FARs perceived mattering, role satisfaction, relationship between the two variables, and the experiences and interactions that affected their perceptions of mattering. Three hundred and two NCAA FARs participated in the survey and results demonstrated that overall FARs perceived they mattered and had high satisfaction in their role. Open-ended responses expanded this sense of mattering by situating it within recognition for service, contributions to decision-making and communication with leadership, and aiding student-athlete success. However, when mattering was not felt, it was due to exclusion from leadership, lack of power, and a lack of compensation. Thus, practical and managerial implications are provided to ensure the role of the FAR is furthering the goals of both academic and athletic communities alike on their campuses.
Diagnósticos de enfermagem formulados em atendimento ambulatorial para as pessoas com esclerose lateral amiotrófica
Authors: Ferreira Júnior Gerson Trinchão , Do Rosário Luana Carvalho , Ferreira Marilaine Matos de Menezes
Published: February 2025

RESUMO | OBJETIVO: Identificar os Diagnósticos de Enfermagem (DEs) formulados pelo enfermeiro na assistência às pessoas com Esclerose Lateral Amiotrófica (ELA) em um ambulatório especializado. METODOLOGIA: Trata-se de um estudo de análise documental, sendo descritivo e exploratório com análise quantitativa; com coleta de dados ambispectivos (retrospectiva de 2022 a agosto de 2023 e prospectivo, de setembro a dezembro de 2023) realizado em um ambulatório especializado em Doenças Neuromusculares - Salvador, Bahia. A população do estudo constitui-se de indivíduos com ELA em acompanhamento ambulatorial. Os dados foram analisados pela estatística descritiva (frequência absoluta e relativa) e coletados em prontuários de pessoas com diagnóstico médico de ELA que vem sendo acompanhados no ambulatório. Foram obtidos dados clínicos para avaliação e validação dos DEs encontrados.  RESULTADOS: Os dados obtidos em 25 prontuários com ELA esporádica; maior frequência no sexo masculino (64%); idade entre 34 e 80 anos, com média de idade de 61,2 anos; média de idade de 53,3 anos quando confirmaram o diagnóstico médico. Foram identificados 11 DEs, sendo os mais prevalentes o Risco de Lesão de Pele (60%) e Risco de Queda (44%). CONCLUSÃO: A elaboração de DEs precisos e adequados à condição do paciente possibilitam a reflexão e tomada de decisão pelos enfermeiros, e consequentemente, uma assistência mais assertiva e completa.
Transfer by admin 2 v1
Authors: Martinez Alberto
Published: February 2025

this is just a test
FOLKLORE ARCHAICS AS A SOURCE OF RESEARCH OF PRE-MORPHOLOGICAL LANGUAGE RELICS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Lysiuk Nataliia А.
Published: February 2025

This article shows that due to the high degree of sacralization, archaic folklore texts preserve relics and rudiments of pre-morphological mechanisms. Professor Kostyantyn Tyshchenko’s contribution to the theory of glossogenesis allows us to consider the language of folklore as a relic phenomenon since archaic folklore texts, keeping primary speech phenomena, contain factual evidence in favour of the truth of his assertions. The first human words, such as onomatopoeia, exclamations, and glossolalia, are unusually frequent in archaic folklore; they play more important roles and perform broader functions than today. From the mythologic perspective, each environmental object and phenomenon was imagined to be alive, and folkloric onomatopoeias reproduced their speech. Acoustic imitations serve for communication on a practical level with people and animals and on a symbolic level with supernatural beings; as ideophones, they become the sound portraits/passports of objects and phenomena. Folkloric exclamations have a unique meaning; their peculiar features are uncustomary pronunciation, blurred semantics, quasi-grammar, ritual functions; seasonal, daily, and gender characteristics.

Folklore texts are abundant in lalias, which reproduce signs of otherworldly speech. Palilalias denote quantitative and/or qualitative characteristics of objects. The phonetic originality of these texts is determined by reduplications in the form of constant epithets, palilogies, two- and three-fold repetitions of words, their combinations, lines (in particular, epistrophe, refrains), anaphors, epiphoras, anagrams, etc., as well as folklore formulas, actions, situations. Oxylalias and azhitolalias serve for pronouncing spells and tongue twisters; xenolalias are used in spells and children’s folklore. Glossolalias are presented in folklore as abracadabras with quasi-grammatical desemantized forms.
Economic effectiveness of fixed-dose combination of alogliptin and pioglitazone in diabetes mellitus treatment
Authors: Zyryanov S. К. , Dyakov I. N.
Published: February 2025

Objective: to comparatively assess the weighted average costs associated with the use of alogliptin-pioglitazone combination versus glucagon-like peptide-1 receptor agonists (GLP-1 RAs).

Material and methods. A retrospective study involved pharmacoeconomic analysis, including cost-minimization analysis and budget impact analysis, with consideration to the efficacy of the compared therapeutic regimens. Data regarding treatment regimens and safety profiles of the alternatives were obtained from the published results of phase III clinical trials and clinical guidelines. Drug pricing information was derived from the state registry of maximum retail prices and auction results.

Results. According to the budget impact analysis, the fixed-dose combination of alogliptin and pioglitazone in the treatment of patients with type 2 diabetes significantly reduces the total costs associated with the administration of hypoglycemic agents and management of concomitant cardiovascular complications. A complete replacement of GLP-1 RAs with the alogliptin-pioglitazone combination in the treatment of 83,582 patients is expected to reduce costs by 42.1% (or by 10,934.5 million rubles) over 3 years. The savings generated from this replacement will enable alogliptin-pioglitazone combination therapy for additional 18,622 patients with type 2 diabetes in the first year and 21,103 patients in subsequent years.

Conclusion. The use of alogliptin-pioglitazone combination as an alternative to GLP-1 RAs appears economically justified and reasonable with respect to reducing costs associated with hypoglycemic therapy and treatment of cardiovascular events.
Investigação da Aprendizagem de Conceitos de Estatística no Ensino Médio Subsidiada pela Modelagem Matemática
Authors: Silva Ajineudo Ferreira da , Oliveira Glaydson Francisco Barros de , Paulino Otávio Floriano
Published: February 2025

Este artigo apresenta um mapeamento feito por estudantes acerca do número de plantas pertencentes a um bioma, de modo a proporcionar aprendizagem sobre variabilidade estatística, objetivando investigar suas contribuições para a aprendizagem dos estudantes do ensino médio de uma escola pública no município de Lucrécia-RN. Para tanto, fundamentado no que preconizam o Referencial Curricular Potiguar e a Base Nacional Comum Curricular, adotou-se a modelagem matemática e a atividade de campo como metodologias de aprendizagem, e ainda os processos investigativos propostos por Veleda e Burak (2020), contextualizados na estatística. Como resultado da investigação, pôde-se concluir que os estudantes apresentaram importante evolução no saber estatístico e desenvolveram criticidade quanto a questões como desmatamento e seus impactos ambientais, diminuição de espécies arbóreas, importância dos insetos para a produção agrícola e a desertificação, todas a partir das interpretações de seus próprios resultados.
Palavras-chave: Estatística. Modelagem Matemática. Atividade Investigativa.
Abstract
This article presents a mapping made by students about the number of plants belonging to a biome, in order to provide learning about statistical variability, aiming to investigate their contributions to the learning of high school students from a public school in the municipality of Lucrécia-RN. For that purpose, based on what the Potiguar Curricular Reference and the National Common Curricular Base recommend, mathematical modeling and field activity as learning methodologies and the investigative processes proposed by Veleda and Burak (2020) were contextualized in statistics. As result of the investigation, it could be concluded that the students presented an important evolution in their statistical knowledge and developed criticality regarding issues such as deforestation and its environmental impacts, reduction of tree species, importance of insects for agricultural production and desertification, all based on interpretations of their own results.
Keywords: Statistics. Mathematical Modeling. Investigative Activity.
Procedimientos guiados por ultrasonido en el punto de atención (POCUS): desde la óptica pediátrica
Authors: Gutiérrez Hernandez ALFREDO , Arellano Maldonado Graciela Guadalupe , Palma Pérez Ricardo
Published: February 2025

La utilización del modelo de ecografía en el punto de atención a veces mencionada como POCUS por sus siglas en inglés (Point of Care Ultrasound) para guiar los procedimientos invasivos en pediatría, ha generado un cambio de paradigma en la atención médica, permitiendo una visualización e interpretación inmediata de imágenes a la cabecera del paciente. Esta técnica, que inicialmente se utilizó en adultos, se ha posicionado con buena aceptación entre los pediatras, mejorando la precisión y seguridad en la ejecución de diferentes procedimientos. El uso del POCUS ha sido respaldado por la Academia Americana de Pediatría y diferentes asociaciones de medicina crítica y de urgencias pediátricas, lo que ha permitido su expansión significativamente. En México se está adoptando rápidamente, a pesar de los desafíos que se enfrentan en su utilización. El objetivo de esta revisión narrativa es describir la evidencia sobre la efectividad y seguridad del POCUS, resaltando su impacto en la mejora de los resultados clínicos y la reducción de complicaciones en procedimientos invasivos.
Osobowościowe uwarunkowania samodzielności wychowanków placówek resocjalizacyjnych
Authors: Zięciak Monika
Published: February 2025

The work was created as a result of the search for an answer to the question about the determinants of the development of independence of pupils of rehabilitation institutions, and therefore concerns an important phenomenon for both educational sciences and the practice of resocialization, which has so far been little subject to scientific exploration. The aim of the study was to recognize the features of independence declared by minors staying in the MOW and to explain the relationship between the personality traits of the pupils, i.e. self-esteem, anxiety, sense of locus of control, social competence and demoralization and the scope and degree of their independence. Therefore, in the first theoretical part of the work, the concept of independence is discussed and the profile of a pupil from MOW is described, in order to look at personality traits characteristic of social maladjustment and showing relationships with human independence. Attention was also paid to the objectives and tasks of the rehabilitation of minors, showing the external factors conditioning the preparation of minors for independence in life. In the second part, the methodological assumptions are followed by the results of the research along with their interpretation. The summary contains the most important conclusions and recommendations for the practice of resocialization.
ERECTILE/SEXUAL FUNCTION OF FRONTLINE AND NON-FRONTLINE HEALTH CARE PROFESSIONALS DURING COVID-19 PANDEMIC: CROSS-SECTIONAL STUDY
Authors: De Barros Cavalcanti Michelutti Luciana , Deyanu Alvear Pérez Constanza , Pasqualotto Luísa , Volpato Maria , Regina Silva Valéria , Emmanuel Pedro de Paiva Teixeira Lucas , Botelho Simone
Published: February 2025

Abstract
Aim: To compare the sexual/erectile function between health professionals working or not on COVID-19 frontline efforts, considering the presence of Post-traumatic Stress Disorder (PTSD), frequency of sexual activity, sexual complaints and the fact of being in social isolation with the partner. Methods: Cross-sectional study which interviewed health professionals of both sexes, older than 18 years, through Google Forms, using the questionnaires: Female Sexual Function Index (FSFI), International Index of Erectile Function (IIEF-5) and Impact of Event Scale-Revised (IES-R, PTSD), with the investigation of sex life aspects during the pandemic. Spearman correlation, Shapiro-Wilk, Kruskall-Wallis, Chi-squared and Dwass-Steel-Critchlow-Fligner tests were performed using R software, 2020. Results: It was verified higher sexual dysfunction among non-frontline women (66.9%). The women with lower FSFI score presented: higher IES-R score, identifying PTSD present: 18.6 vs absent: 19.9 (p<0.00). Those who maintained or increased sexual activity (FSFI=20.6 and 20.8, respectively) vs decreased (FSFI=18.5), suspended (FSFI=15.0) or no sexual activity (FSFI=10.4) (p<0.00); and those never presented any sexual complaint (FSFI=20.1) vs have already presented (FSFI=19.0) or currently present (FSFI=16.2) (p<0.01). On the other hand, higher FSFI score was found among the female frontline professionals with sexual activity (frontline=21.1 vs non-frontline=20.6; p<0.00); previous sexual complaint vs current complaint (FSFI=19.7 vs 17.4; p<0.01). Among men, a difference was observed in non-frontline professionals (previous sexual complaint: IIEF-5=24 vs current complaint: 23; p=0.02). Conclusions: There was an association between non-frontline professionals and the presence of sexual dysfunction.
RODAS DE CONVERSA COM SERVIDORES DE UMA UNIVERSIDADE PÚBLICA SOBRE TELETRABALHO E SAÚDE – UM RELATO DE EXPERIÊNCIA
Authors: Ferreira Candido Ana Carolina , Baracho de Alencar Maria do Carmo
Published: February 2025

The aim of this article is to report on the experience of a university extension activity involving conversation circles for civil servants at a public university on teleworking and health. A list of civil servants from different sectors of a public university campus who were teleworking (partially or totally) was obtained and then online meetings were held via Google Meet. A total of three meetings were held and 13 civil servants of both sexes took part, the majority of whom were female (61.5%) and partially teleworking (92.0%). The following stood out about teleworking: little social interaction, flexible working hours, improved quality of life, productivity and time savings. With regard to ergonomic risks, pain in the lower back related to the use of unsuitable chairs. Listening spaces are necessary for workers' health and should be encouraged within companies and institutions.
Time Factor in the Educational Process of a Physical Training Teacher
Authors:   Saratov State University, Milekhin A.V.
Published: February 2025

The article views the problems of education of teachers of physical
training, which deal with mastering of time planning peculiarities,
characterizing sport pedagogue activity. The competent relevance of
time usage is stressed for not only training of sport movements and
acquiring the study sport material, but also for demonstrating these
sport movements during the pedagogical practice of students. The
proper using of time is a significant part of professional training that
has determinative influence on the results of any activity.
Between Motherland & Marketplace
Authors: Nair Shama
Published: February 2025

This is a Photoessay and does not have an abstract. Please download the PDF or view the article in HTML.
Bridging Cultures: The Role of Qatari Heritage Districts in Promoting Cultural Interactions, Acculturation, and Identity Formation Among Malayalee Migrants
Authors: Menon Lakshmi Venugopal
Published: February 2025

This paper examines the interaction of Indian Malayalee migrants with Qatari heritage districts highlighting the latter’s role in fostering cultural integration, acculturation, and identity negotiation. Through a case study of a three-generation Malayalee family, the author explores the varying degrees of engagement between short- and long-term migrants, emphasizing the sociocultural and psychological impacts of heritage districts. The findings reveal that while short-term migrants engage in a surface-level exploration of cultural spaces, long-term migrants develop deeper connections, integrating these districts into their lives and forming meaningful relationships with local culture. This paper also explores and underscores the challenges of maintaining cultural identity and belonging in a transnational multicultural setting, illustrating how heritage districts become spaces for cultural exchange.
Bibliometrična analiza in razvoj modela uporabnosti digitalnega dvojčka v vseh fazah življenjskega cikla premoženja
Authors: Debeljak Žiga , Maletič Matjaž , Maletič Damjan
Published: February 2025

V sodobnem poslovnem okolju je učinkovito obvladovanje premoženja ključno za ustvarjanje vrednosti v organizacijah. Soočamo se z vprašanji, kot so, kaj pomeni imeti DT za fizično premoženje/sredstvo? Kakšna je vloga DT na področju obvladovanja premoženja/sredstev (Errandonea idr., 2020)? Cilj pričujočega poglavja je izdelati celovit pregled trenutne uporabnosti digitalnega dvojčka (DT) v vseh fazah življenjskega cikla premoženja. Poglavje obravnava problematiko s sistematičnim pregledom literature, identificiranjem ključnih ugotovitev ter analizo vloge DT pri obvladovanju premoženja. Metodologija reševanja vključuje temeljito raziskavo obstoječih objavljenih del (v zbirki Scopus) o DT, nato pa sintezo pridobljenih podatkov za razumevanje vloge DT pri obvladovanju premoženja. Rezultati bodo služili kot osnova za pripravo analitičnih ugotovitev, ki bodo organizaciji omogočile ustvarjanje vrednosti iz premoženja na osnovi digitalnega dvojčka.
„Z oficyny do centrum domu”. O nowym wymiarze przestrzennym i kulturowym kuchni we współczesnym urządzaniu wnętrz
Authors: Kowalczyk Paulina
Published: February 2025

Autorka artykułu podejmuje próbę prześledzenia zmian znaczenia kuchni oraz czynników kulturowych i symbolicznych wpływających na marginalizację tej przestrzenni w nowożytnej „geografii” domu. Stawia pytanie o trwałość pewnych figur wyobraźni, które wyznaczały hierarchię w układzie przestrzennym domu. Analizując dawne poradniki i traktaty architektoniczne, jak i współczesne czasopisma i strony internetowe poświęcone aranżacji wnętrz, autorka stara się ukazać owe przemiany i nowy wymiar przestrzenny oraz kulturowy kuchni.
Application of Fertility Capability Classification System to the Soils in the Ganjigatti Sub-watershed of Dharwad District, Karnataka
Authors: Yadav M. Bhargava Narasimha , Patil P.L. , Kumar T. Sunil , Rundan V. , Prasad V. , Nthebere Knight
Published: February 2025

Background: The fertility capability classification (FCC) system has been used to group soils with the same kind of limitations from the point of view of fertility management in the Ganjigatti sub-watershed of Dharwad district of Karnataka. Methods: A detailed soil survey of the study area was carried out using a high-resolution satellite image (Worldview2 - 50cm SR) and cadastral maps. The image and scanned toposheet were geocoded and subsets were created in ArcGIS 10.8.2 at 1:7,920 scale. After correlating the soil properties of pedons, nine representative pedons were selected and presented in the present research paper. The information of nine soil series identified during the detailed soil survey has been analyzed into eight FCC units. Result: According to FCC, the representative pedons were classified as CRdmr+(MRK), LCdkr++ (UGK), LRdr++ (KMD), LRdemr+ (SSK), Cdr+ (KRK and MVD), LCdkr+ (BGH), Ldr+ (GJG) and Cbdmv (ASR). The major soil constraints identified through condition modifiers in the descending order were dry soil moisture (d), gravelliness (r), low organic carbon content (m), low K reserve (k), low cation exchange capacity (e), basic reaction (b) and vertic properties (v). By computing FCC units an attempt has been made to highlight the fertility constraints and measures to revert the situation for sustainable production.
Struktur Mikroanatomi dan Histomorfometri Duodenum Tikus Putih Jantan setelah Pemberian Doksisiklin dan Ekstrak Etanol Bunga Telang
Authors: Putri Amalia , Kasiyati Kasiyati , Sitasiwi Agung Janika
Published: February 2025

Antibiotik, seperti doksisiklin dapat digunakan untuk mengatasi penyakit infeksi,
namun jika digunakan secara berlebih, akan menghasilkan radikal bebas berlebih dan
menyebabkan stres oksidatif yang mampu merusak duodenum tikus putih. Antioksidan yang
dimiliki oleh bunga telang dapat menangkal radikal bebas yang terdapat di dalam tubuh.
Radikal bebas juga ditemukan pada duodenum sehingga pemberian bunga telang berpotensi
mencegah kerusakan duodenum sebagai tempat absorpsi nutrien. Tujuan dari penelitian ini
adalah untuk mengetahui pengaruh pemberian ekstrak etanol bunga telang terhadap struktur
mikroanatomi dan histomorfometri duodenum tikus putih. Penelitian ini menggunakan
Rancangan Acak Lengkap (RAL) dengan 20 ekor tikus putih jantan dan dibagi menjadi
empat perlakuan, yaitu P0 (akuades), P1 (doksisiklin 6 mg/ekor/hari), P2 (ekstrak etanol
bunga telang 90 mg/ekor/hari), dan P3 (doksisiklin 6 mg/ekor/hari dan ekstrak etanol bunga
telang 90 mg/ekor/hari). Bahan uji diberikan secara oral dan dilakukan selama 14 hari.
Sediaan histologi duodenum dibuat dengan menggunakan metode parafin dan pewarnaan
hemaktosilin-eosin. Data dianalisis menggunakan uji sidik ragam dengan taraf signifikasi
5% dan hasil menunjukkan bahwa pemberian doksisiklin dan ekstrak etanol bunga telang
pada histomorfometri duodenum tikus putih berbeda tidak signifikan (P>0,05), namun
terdapat perubahan pada struktur mikroanatomi dan sel epitel vili duodenum. Simpulan
penelitian ini adalah pemberian doksisiklin dan ekstrak etanol bunga telang tidak mengubah
morfometri duodenum, namun komponen aktif dari bunga telang berkontribusi pada
perbaikan struktur duodenum yang mengalami kerusakan pada tikus putih jantan.
The effect of dislocations on phase transition in PbZrO3-based antiferroelectrics
Authors: Li Zhenqin , Fu Zhengqian , Hu Tengfei , Yu Ziyi , Zhang Linlin , Chen Xuefeng , Wang Genshui , Xu Fangfang
Published: February 2025

Dislocations in perovskite oxides have an important influence on their macroscopic performances. In this work, we report abundant dislocations in PbZrO3-based antiferroelectric (AFE) ceramics, which manifest themselves mainly as dislocation arrays with Burgers vectors along the <110> direction. We demonstrate that these dislocation arrays were emitted from the grain boundaries and exhibit a pure screw character with glide systems of <110>{$$ 1\bar{1} 0 $$ }. The in situ transmission electron microscopy investigations indicate that dislocations are beneficial for stabilizing the AFE phase in the heating process and serve as nucleation sites for the AFE phase during cooling. Meanwhile, the stress field of dislocation arrays also plays a critical role in the growth of AFE domains, which can be applied for regulating domain size and orientation. These findings provide the basis for dislocation engineering in AFE ceramics.