bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of serum-glucocorticoid-regulated kinase (SGK1) in arterial reactivity
Authors:   , Nahar Lutfun
Published: October 2023

[EMBARGOED UNTIL 8/1/2024] Objective: In the vascular system, aldosterone exerts several actions via genomic and non-genomic pathways through MR receptor-dependent/independent mechanisms. Aldosterone exerts its effect by the transcription of target genes including the SGK1, EnNaC, and Na+/K+ -ATPase. Preliminary studies from our group observed a change in EnNaC current in SGK1 global knockout mice with aldosterone (10nM) treatment for 24 hours. We thus hypothesized that altered expression of SGK1, particularly within the endothelium, affects vascular tone and reactivity. Method and Results: The current studies used (SGK1+/+ or SGK1fl/fl) mice as controls, SGK1 global-knockout (SGK1-/-), and endothelial cell-specific SGK1 knockout (EcSGK1-/-) mice. Baseline aortic vasomotor responses were determined using in vitro isometric myography. Vasomotor responses were examined to increasing concentrations of the vasoconstrictor, U46619 as well as the vasodilators, ACH, and SNP. In additional studies, 2 mm rings from the thoracic aorta of mice were collected and incubated under control conditions or in the presence of exogenous aldosterone (10nM & 100nM) for 24 hours and 48 hours or acutely for 10 minutes directly in the myograph bath. Arterial vasomotor responses were measured as above. There were no significant differences in baseline aortic vasomotor responses between the global SGK1 and EcSGK1 controls and KO groups. Following acute aldosterone treatment, the study saw a significant difference in vascular relaxation responses in global SGK1 & EcSGK1 groups. Conclusion: Collectively, under the condition of these experiments our data show no significant differences in vasoreactivity between the control and SGK-1 deficient groups. Ongoing studies are aimed at determining the impact of treatment duration and the requirement for factors such as an altered availability of salt.
The Impacts of Bankruptcy and Judicial Recovery Law Reform on the Liability of Managers of Companies under Judicial Recovery
Authors: Pimentel Junior Washington Luiz Dias , Coêlho Bruno César de Carvalho , Oliveira Filho João Glicério de
Published: October 2023

The responsibility of partners and administrators for the company’s obligations in the context of Judicial Recovery and Bankruptcy has gained specific contours following the promulgation of Law No. 14,112/2020, which amended Law No. 11,101/2005 (the Recovery and Bankruptcy Law). Through bibliographic and qualitative research, this article aims to evaluate, from the perspective of fiduciary duties, the limits of administrators’ responsibility regarding the company’s obligations in recovery, through an analysis of the changes introduced by Law No. 14,112/2020 and their effects. Therefore, it is understood that mere non-compliance or any “bad decision” will not impose liability on administrators. It is essential for there to be a breach of fiduciary duties of diligence, loyalty, and information to trigger the accountability action or the incident of disregarding the legal personality, always in an exceptional manner, prioritizing the independence of the company’s management and excluding the previously applicable jurisprudential application.
УПРАВЛІННЯ ПРОЄКТАМИ В ТУРИЗМІ: АДАПТАЦІЯ ДО НОВИХ ВИКЛИКІВ В УМОВАХ СТРІМКИХ ЗМІН
Authors: Теребух А.А. , Роїк О.О.
Published: October 2023

У статті обґрунтовується актуальність питання щодо визначення підходів, інструментів та джерел повоєнного відновлення України. За таких умов, крім агропромислового комплексу, металургії, переробної галузі та ІТ-сектору, Україна має значний потенціал в сфері туризму. В умовах трансформаційних змін середовища виживання туристичної сфери потребує формування ефективного управління проєктами в туризмі в умовах війни. Метою дослідження є аналіз теоретико-практичних аспектів реалізації системи управління проєктами в туризмі в умовах адаптації до нових викликів. Практичне значення дослідження – використання особливостей управління проєктами в туризмі з метою отримати соціально-економічний синергетичний ефект, який виявиться в успішному завершенні проєкту. У перспективі подальші дослідження – моделювання розвитку туризму в Україні з урахуванням інноваційних особливостей методології проектного управління.
МЕТОДИЧНИЙ ПІДХІД ДО УПРАВЛІННЯ ЗАЛУЧЕННЯМ ЗАЦІКАВЛЕНИХ СТОРІН В ДЕВЕЛОПЕРСЬКИХ ПРОЄКТАХ
Authors: Фісуненко П.А. , Легостаєв І.М.
Published: October 2023

Стаття присвячена вивченню та удосконаленню підходу до управління залученням стейкхолдерів до розробки та реалізації девелоперських проєктів. Обґрунтовано, що коло стейкхолдерів є надзвичайно широким, що потребує підвищеної уваги до управління їх залученням. Досліджено існуючі методи та інструменти, які застосовуються в ході управління залученням зацікавлених сторін. Здійснено їх розподіл на загальні, методи управління проєктами, методи ідентифікації та аналізу стейкхолдерів та методи комунікативного управління. Представлено інструментарій управління залученням стейкхолдерів, який відповідно згруповано у блок орієнтування та блок комунікування. Сформовано методичний підхід до управління залученням зацікавлених сторін в девелоперських проєктах. Доведено, що завдяки умілому балансуванню інтересів стейкхолдерів як у процесі управління залученням зацікавлених сторін девелоперського проєкту, так і в межах циклу отримання результатів управління залученням зацікавлених сторін девелоперського проєкту, стає можливим загальне підвищення ефективності девелоперського проєкту.
Analisis Pelaksanaan Fungsi Pengawasan Badan Permusyawaratan Desa terhadap Pengelolaan Keuangan Desa
Authors: Hermawansyah Ady , Ramli Ramli , Fitri Azmi Ilima , Muhammad Ashar
Published: October 2023

Pembangunan desa merupakan salah satu program prioritas Presiden Ir. Joko Widodo. Hal ini tertuang dalam Nawa Cita ketiga, yaitu membangun Indonesia dari pinggiran dengan memperkuat daerah dan desa dalam kerangka negara kesatuan. Pada tahun 2021, pemerintah mengalokasikan dana sebesar 72 triliun untuk 71.074 desa yang tersebar di 34 provinsi dalam bentuk dana desa. Setiap desa mendapat anggaran desa sekitar 1 miliar hingga 2 miliar per tahun. Selain dana desa, desa juga mendapat anggaran dana desa yang bersumber dari APBD kabupaten. Dengan besarnya anggaran tersebut, diharapkan peran Badan Permusyawaratan Desa dalam pengawasan pengelolaan keuangan desa dapat efektif.

Metode yang digunakan adalah deskriptif kualitatif. Penelitian ini dilakukan di Provinsi Sulawesi Selatan yaitu Desa Bangkelekila di Kecamatan Bangkelekila, Kabupaten Toraja Utara, Desa Latimojong, Kecamatan Buntubatu, Kabupaten Enrekang dan Desa Mallari, Kecamatan Awangpone, Kabupaten Bone dengan menentukan key informan di setiap desa dengan menggunakan metode purposive sampling. . Teknik analisis data menggunakan teknik analisis data Miles dan Huberman melalui tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa semakin tinggi IDM (Indeks Desa Berkembang) suatu desa, maka semakin besar kemungkinan desa tersebut memiliki BPD (Dewan Perwakilan Desa) yang lebih handal dalam melakukan checks and balances dan dalam memenuhi fungsi pengawasan yang diberikan. serta kurangnya pemahaman BPD mengenai fungsi dan peraturan pengawasan pengelolaan keuangan desa.

Kata Kunci: dana desa, pengelolaan dana, pengawasan BPD
Pengendalian Harga Pangan Melalui Penghitungan Indikator Proxy Inflasi
Authors: Puspita Widasari Nova , Tanur Erwin , Uli Sitanggang Yuliana Ria , Situmorang Martina
Published: October 2023

Penanganan inflasi adalah agregat kerja sama pusat dan daerah. Maka untuk melihat upaya pemerintah daerah dan Tim Pengendalian Inflasi Daerah dalam pengendalian inflasi, diperlukan indikator kinerja yang terukur, fokus cepat dan akurat untuk pengambilan kebijakan, program dan target. Salah satunya adalah indeks yang dihitung oleh BPS yaitu Indeks Perkembangan Harga. Indeks Perkembangan Harga merupakan salah satu Indikator Proxy Inflasi selain Indeks Disparitas Harga dan Koefisien Variasi Fluktuasi Harga Komoditas yang dapat menguji dampak pengambilan kebijakan dan program pengendalian inflasi terhadap capaian hasil. Penelitian ini menggunakan pendekatan deskriptif kualitatif dengan sumber data berupa data sekunder yang berasal dari Data SP2KP Kementerian Perdagangan, Kementerian Dalam Negeri dan Badan Pusat Statistik. Dari hasil penelitian diperoleh pembahasan dan kajian terkait kebijakan pengendalian inflasi juga disajikan dengan membandingkan perhitungan angka Indeks Perkembangan Harga, Indeks Disparitas Harga dan Koefisien Variasi Fluktuasi Harga Komoditas dengan hasil bahwa kabupaten/kota dengan persentase kenaikan Indeks Perkembangan Harga tertinggi adalah Kabupaten Nias, sedangkan penurunan harga tertinggi terjadi di Kota Tebing Tinggi. Komoditas bahan pangan yang memiliki fluktuasi harga tertinggi adalah cabai merah, bawang merah dan cabai rawit. Cabai Merah adalah komoditas yang fluktuasi harganya cukup signifikan selama minggu kelima bulan Maret 2023 di sembilan kabupaten/kota se-Sumatera Utara.                                                                                                                                                                            

Kata Kunci: indeks perkembangan harga, indeks disparitas harga, koefisien variasi fluktuasi harga, inflasi
Inovasi sebagai Strategi Reformasi Administrasi Pemerintah Daerah : Studi Pemerintah Daerah di Meksiko dan Indonesia
Authors: Ranintya Yusuf Rima , Aji Nugroho Alih
Published: October 2023

Penelitian ini bertujuan untuk melihat hubungan desentralisasi dan inovasi daerah, dengan mengambil studi kasus inovasi pemerintah daerah di Kota Meksiko, Kabupaten Jembrana, dan Pemerintah Provinsi Jawa Barat. Metode penelitian menggunakan studi literatur. Data Meksiko diambilkan dari hasil penelitian data sekunder dari 64 inovasi yang dilakukan pada 30 pemerintah daerah di Meksiko. Sedangkan data di Kabupaten Jembrana dan Pemerintah Provinsi Bali diambil dari penelitian terdahulu, jurnal dan sumber data sekunder lainnya. Hasil penelitian menunjukkan bahwa inovasi daerah tumbuh karena inisiasi mandiri inovator maupun sebagai respon atas permasalahan yang muncul dalam masyarakat. Inovasi daerah seringkali digunakan sebagai sarana politik pemimpin daerah. Kepemimpinan menentukan keberhasilan inovasi. Permasalahan yang muncul dalam inovasi daerah adalah keberlanjutan inovasi daerah. Saran yang diberikan diantaranya melalui pelembagaan inovasi secara formal, membangun transparansi dan akuntabilitas, membuka ruang partisipasi dan kolaborasi pada stakeholders yang lebih luas, memilih prioritas program yang relevan, serta membagi peran dan tanggungjawab kepada stakeholders dengan jelas dan akuntabel dalam memperkuat inovasi.

Kata Kunci: inovasi; reformasi birokrasi; pemerintah daerah; studi komparasi
Correlation of axial loaded magnetic resonance imaging with clinical symptoms in lumbar spinal canal stenosis patients
Authors: Son Nguyen Van , Son Vi Truong , Hoat Luu Ngoc , Toan Do Thi Thanh
Published: October 2023

There are cases when symptoms are available, but no abnormal stenosis is found in MRI and vice versa. Axial-loaded MRI has been shown that it can demonstrate more accurately the real status of spinal canal stenosis than conventional MRI. This is the fi time we applied a new system that we have recreated from the original loading frame system in order to fi with the demands of Vietnamese people. Sixty-two patients were selected from Phu Tho Hospital in Phu Tho Province, Vietnam, who fulfi the inclusion criteria. The Anterior-posterior diameter (APD), Dura Cross-sectional Area (DSCA) in conventional MRI and axial loaded MRI, and changes in APD and DCSA were determined at the single most constricted intervertebral level. The APD and DCSA in axial loaded MRI had very good signifi correlations with VAS for back pain (rs=0.83, 0.79), leg pain (rs=0.69, 0.57) and JOA score (rs=0.70, 0.65). APD and DCSA in axial loaded MRI signifi correlated with the severity of symptoms. Our axial loading MRI provides more valuable information than the conventional MRI for assessing patients with LSCS.
A Story of Perspective of Persistence and Diligence: The Life of Victor Gondos, Jr.
Authors: Rakita Eszter
Published: October 2023

The article explores the unique career of a second-generation Hungarian-American immigrant, Victor Gondos, Jr. Gondos was born in Budapest in 1902, as a son of a Hungarian teacherturned American entrepreneur, Victor Gondos, Sr. The family immigrated into the United States in 1911. During his college years, Victor Gondos, Jr. was about to start a military career but, unfortunately, he almost became permanently disabled due to an unexpected illness. After his recovery, he was forced to start an almost completely new life. He had to prevail in a new field as an archivist and military historian that, however, proved to be more successful than he would have ever expected. Victor Gondos, Jr.’s life is a story of resilience, persistence, and bravery, overcoming great obstacles and reaching goals despite many hindering circumstances. His story can also be interpreted as an example of an ambitious immigrant who wants to prove his loyalty to his new home country through actions.
ELDERLY EDUCATION AND LIFELONG LEARNING: LEGAL AND SHARIAH PERSPECTIVES
Authors: Abdul Mutalib Mashitah , Kamaruzaman Nur Al-Farhain , Abdullah Nur Aina
Published: October 2023

Prioritising the elderly should be a national priority before Malaysia turns into an old country, which is anticipated to happen in the year 2030. Reimagining what quality aging will entail in the future is required to provide older people in Malaysia the best possibilities for a quality life. One way to ensure that the elderly will age graciously is through education or learning. However, there are various barriers and challenges which limit the development of elderly education and lifelong learning in Malaysia. This study, therefore, focuses to explore prominent issues regarding elderly education and lifelong learning. This would include analysing the existing laws and policies related to the elderly. Apart from that, the Shariah perspectives on this area are also discussed to illustrate the importance of learning for elderly. This study is a qualitative legal study employing doctrinal approach and document analysis. The findings illustrate that, although there are existing legal instruments and syariah authorities on the significance of elderly education and learning at a later stage, a policy reform is needed especially in terms of the strategies and implementation of the polices. The policy should be reformed, the challenges should be addressed, coordination and collaboration should be enhanced. The policies need to be more inclusive involving higher numbers of senior citizens in Malaysia. Additionally, a mechanism is required to educate the elderly about the importance of learning at a later stage as reflected in the national policies and shariah principles. This paper shall assist the policy makers in enhancing the policy on older people particularly on the aspect or elderly education and life learning in Malaysia. The challenges faced by Malaysia specifically in ensuring the inclusiveness of the programmes involving senior citizens in Malaysia shall be lessons for other countries in strengthening their policies for older people.
ransforming Public Administration with CAF 20 years of the Common Assessment Framework
Authors: Prorok Thomas
Published: October 2023

The CAF is the European Common Assessment Framework for better quality in public administration, and it celebrates its 20th anniversary in 2020. The CAF improves public administration through self-assessment by the employees and executives of "their" organisation. The beginning of the CAF dates back to 1998 when the ministers of the European Public Administration Network (EUPAN) commissioned designing "general principles concerning the improvement of the quality of services provided to citizens". The CAF 2020 is the ﬁfth version of the CAF, and it is designed to be the European guideline for good governance and excellence in public sector organisations. In four chapters, this book provides an overview of how the CAF is contributing to transform public administration. About 30 designated CAF experts from academia and practice offer insights into the impact of the CAF in different ﬁelds of public sector organisations, reﬂecting the powerful role of the CAF in navigating through challenging times. Furthermore, this book provides an overview of the institutional status of the CAF in Europe and internationally, and it shows the necessary steps for further strengthening the CAF as the number one tool for transformation and quality in the public sector. As a resumé of the book, it can be stated that the CAF initiates and accompanies the transformation of public administration, especially through: transforming the organisation towards change and organisational development; transforming public administration towards the Sustainable Development Goals; transforming the public sector towards effective governance, multi-level collaboration and comprehensive policy-ﬁeld-thinking; making public administration and structural reforms successful; and driving states and societies towards European integration and European values.
PERCEPTIONS OF PRIMARY PRE-SERVICE TEACHERS IN THE UTILIZATION OF PLANT IDENTIFICATION APPS AS EDUCATIONAL TOOLS
Authors: Canuto Peter Paul
Published: October 2023

Plant identification apps make learning about plants more convenient. This study explored the participants' perceptions of using three plant identification apps, PlantNet, PictureThis, and LeafSnap, as potential educational tools. Problems experienced, differences in perceptions, and the participants' most preferred apps were also determined. Through purposive sampling, the study engaged 162 primary pre-service teachers in the Cordillera Administrative Region (CAR), Philippines. Data were collected through a developed questionnaire and analysed quantitatively. The questionnaire was reliable with an identified single component for perception. Participants first explored and used the apps to identify local plants, thereafter, responding through an online questionnaire. Results showed that participants strongly perceived the apps as engaging, helpful in plant identification, easy to browse, providing details, effective as emerging tools, and significant for scientific literacy, except for consistency of results. There were significant differences, but with small effect sizes, indicating negligible differences in the perceptions of male and female participants regarding the apps' consistency of results and effectiveness. Weak internet connection was the primary issue affecting the apps' utilization. The pre-service teachers preferred LeafSnap over PictureThis and PlantNet. Conclusively, this study affirmed the potential of the apps for students learning about plants, further supporting their feasibility as emerging educational tools.
Keywords: educational tools, plant identification apps, PlantNet, PictureThis, LeafSnap, primary pre-service teachers
SCIENCE TEACHERS' APPROACH TO CONTEMPORARY ASSESSMENT WITH A READING LITERACY EMPHASIS
Authors: Kerneža Maja , Zemljak Dejan
Published: October 2023

In a sample of 1215 teachers, this study examined the readiness of science educators for assessment in the rapidly evolving landscape of artificial intelligence in education. Participants responded to an online questionnaire during the emergency remote teaching phase, offering insights into the frequency and nature of assessment methods utilized. The research draws a connection between assessment techniques during remote teaching and the emergence of AI in education. The results show that the selected assessment methods vary across teachers, with some specific differences observed in the assessment practices of science teachers. The study underscores the critical role of reading literacy in enhancing student engagement in contemporary learning environments. Moreover, the findings suggest that continuous professional development significantly improves the readiness of (science) teachers for AI-enhanced assessment. Drawing from these insights, recommendations for subsequent research are delineated.
Keywords: artificial intelligence, assessment, reading literacy, science teachers, teacher training
COGNITION AND ATTITUDE TOWARD SUSTAINABLE DEVELOPMENT BEHAVIOR: COLLEGE STUDENTS’ INFORMAL ONLINE LEARNING AS A MODERATION EFFECT
Authors: Liu Qi , Tian Xiaoxia , Bang Younghwan , Park Kyung Hee
Published: October 2023

The social responsibility of college students in the later stages of adolescence for sustainable development is emphasized, and the role of universities has become a crucial task. This study aimed to explore the level of college students' cognition, attitude, and behavior towards sustainable development and the association among them through the moderation effect of informal online learning. The difference verification and structural equation modeling were applied to 559 students who majored in science, and statistical validity was confirmed. Regarding the sustainable development level of college students, there was a significant difference in cognition, attitude, and behavior towards sustainable development between males and females, formal education, and informal online learning. Further, college students’ attitudes towards sustainable development played a significant mediating role between cognition and behavior. The study also found a significant moderation effect of informal online learning on students’ cognition and attitude toward sustainable development behavior. Accordingly, this study suggests that universities should systematically design educational programs to promote college students' behavioral change toward sustainable development through personal life-oriented learning courses.
Keywords: sustainable development behavior, sustainable development cognition, sustainable development attitude, college student, informal online learning
Multiplex immunohistochemistry elucidates increased distance between cytotoxic T cells and plasma cells in relapsed myeloma, and identifies Lag-3 as the most common checkpoint receptor on cytotoxic T cells of myeloma patients.
Authors: Ninkovic Slavisa , Purton Louise E , Harrison Simon J , Quach Hang
Published: October 2023

A dysfunctional immune tumour microenvironment facilitates disease progression in multiple myeloma (MM). Using multiplex immunohistochemistry (mIHC), we described the quantitative and qualitative changes in CD3+ CD8+ cytotoxic T-cells and assess their proximity to malignant plasma cells (PCs) in patients with monoclonal gammopathy of undetermined significance (MGUS), newly diagnosed (ND) and relapsed/refractory (RR) MM. Formalin-fixed, paraffin-embedded trephine sections from patients with MGUS (n=32), NDMM (n=65) and RRMM (n=59) were sequentially stained for CD138, CD3, CD8, and checkpoint receptors (CPR) Tim-3, Lag-3, and PD-1. Halo® image analysis platform was used for cell segmentation and phenotyping, facilitating enumeration of cytotoxic T-cells and analysis of proximity to PCs. The percentage of CD8+ cytotoxic T-cells in proximity to PCs is greater in patients with NDMM than patients with RRMM (at 50gm distance 90.8% vs. 81.5%, p=0.038). There is a trend for more CD3+ T-cells in MGUS (p=0.08) but no difference was observed in the prevalence of CD8+ cytotoxic T-cells (p=0.48). Lag-3 is the most common CPR expressed on cytotoxic T-cells in myeloma (p
Subcutaneous injection of IHP-102 prevents lung vaso-occlusion in sickle cell disease mice
Authors: Dubey Rikesh K. , Vats Ravi , Brzoska Tomasz , Kaminski Tomasz W. , Katoch Omika , Tejero Jesus , Njikang Gabriel , Paderi John , Sundd Prithu
Published: October 2023

Not available.
Radiation Situation Around Commissioning Mine No. 6 of Pjsc ‘Priargunskiy Mining and Chemical Production Association’
Authors:   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Shandala N.K. , Gushchina I.V. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Titov A.V. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Belskikh I.S. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Seregin V.А. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Doroneva T.A. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Isaev D.V. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Starinskiy V.G. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia, Shitova A.A. ,   A.I. Burnazyan Federal Medical Biophysical Center, Moscow, Russia
Published: October 2023

Purpose: Study of the radioecological situation around mine No. 6 of PJSC ‘Priargunsky Industrial Mining and Chemical Association’ named after E.P. Slavskiy" before commissioning. Material and Methods: During the radiation survey, to measure the ambient dose equivalent rate, the pedestrian gamma survey method was used using the portable spectrometric complex MKS-01A ‘Multirad-M’ (Russia) and the dosimeter-radiometer MKS-AT6101s (Belarus). To study the specific activity of radionuclides in the soil, samples were taken in accordance with GOST 17.4.3.01-2017. The activity of gamma-emitting radionuclides was measured on a stationary gamma spectrometer manufactured by Canberra (USA). The activity of 210Po and 210Pb was measured on the radiometric system UMF-2000 (Russia) after their radiochemical extraction from samples. Dose assessment of exposure to biological objects was made using dose coefficients established in ICRP Publication 136, considering recommendations R52.18.820-2015. Results: The results of the study showed that the ambient dose equivalent rate of gamma radiation varied in a wide range from 0.1 to 4.9 µSv/h. The average value in the background areas is 0.14±0.02 µSv/h. The specific activity of natural radionuclides outside the rock dumps, except for 40K, in some areas exceeds the background values up to 10 times. The ecological risk for the considered terrestrial biological objects (grass, shrub, soil worm and mouse-like rodents) does not exceed 10‒2. Conclusion: There are areas on the territory with traces of anthropogenic activity, which led to man-made radiation contamination. The highest levels of ambient dose equivalent of gamma radiation occur near rock dumps. The rest of the territory has local areas with radioactive contamination. Doses of exposure to biological objects don’t have a significant effect on the incidence, reproduction, and life expectancy of terrestrial biological objects.
Investigasi Kesenjangan Pengguna Instant Messenger Ditinjau dari Aspek Desain User Interface dan Teknologi
Authors: Cahyono Taufiq Agung , Fitriyasari Maliatul , Luthfiana Tias Hafidzotul
Published: October 2023

Meningkatnya jumlah pengguna aplikasi instant messenger merupakan sebuah fenoma yang menggambarkan bahwa teknologi komunikasi telah dapat diterima dikalangan masyarakat umum. Namun faktanya aplikasi instant messenger yang memiliki fitur dengan teknologi terbaru, tidak serta merta menjadi pilihan masyarakat. Bahkan tidak sedikit pengguna, yang lebih mementingkan faktor kenyamanan dibandingkan dengan faktor teknologi yang digunakan oleh aplikasi instant messenger. Penelitian ini, bertujuan untuk mengetahui faktor seseorang dalam menetukan aplikasi instant messenger yang digunakan. Metode kuantitatif digunakan dalam penelitian ini dengan membandingkan dua variabel utama yaitu desain user interface dan teknologi yang digunakan. Pengumpulan data dilakukan dengan menyebar kuisioner dan melakukan deep interview kepada 80 responden. Hasil dari peneltian ini menujukan bahwa desain user interface menjadi faktor utama seseorang dalam menentukan penggunaan aplikasi instan messenger.
Heart Rate Variability Indices of Student Pilots Undergo Modifications During Flight Training
Authors: Li Volsi Guido , Monte Ines Paola , Aruta Alessandro , Gulizzi Alfio , Libra Andrea , Mirulla Stefano , Panebianco Gianluca , Patti Giovanni , Quattrocchi Ferdinando , Bellantone Vincenzo , Castorina Walter , Arcifa Stefano , Papale Filippo
Published: October 2023

INTRODUCTION: Heart rate variability (HRV) indicates the temporal fluctuation of the intervals between adjacent beats. HRV expresses neuro-cardiac activity and is generated by heart–brain interactions and dynamics related to the function of the autonomous nervous system
and other components. To investigate this issue, we started a series of experiments by coupling the flight tasks of student pilots and their HRV.METHODS: Before each experimental session, the participating student was fitted with a five-electrode, three-channel Holter electrocardiogram
monitor. We defined three time-phases for each training mission: before flight operations on the ground, during flight operations, and after flight operations on the ground. The HRV analysis was performed by quantifying some indices of the time domain and the frequency domain.RESULTS:
The analysis of RR-wave intervals revealed two types of trends: 1) students whose RR intervals decreased during flight operations compared to before flight ground operations; and 2) students whose RR intervals increased during flight operations compared to before flight ground operations.
These differences found in the RR intervals produced changes in the indices of both the time and frequency domains of the two students’ samples.DISCUSSION: Flight training involves regular and advanced tasks and/or emergency situations. When this happens, the total power of
the heart decreases because the RR intervals are forced toward low values. Flight activity involves continuous demanding tasks that can be potentially read by an analysis of the HRV; a high HRV ensures better management of tasks that require a greater commitment of cardiovascular function.Li
Volsi G, Monte IP, Aruta A, Gulizzi A, Libra A, Mirulla S, Panebianco G, Patti G, Quattrocchi F, Bellantone V, Castorina W, Arcifa S, Papale F. Heart rate variability indices of student pilots undergo modifications during flight training. Aerosp Med Hum Perform. 2023; 94(11):835–842.
Effectiveness Hydroxyapatite from Chicken Eggshells for Adsorption of Chromium (VI) Metal Ion Electroplating Waste
Authors: Ismawati Afifah Nur , Iryani Ani , Kusumawadani Linda Jati
Published: October 2023

The largest source of waste comes from household activities. One of the wastes that comes from household activities is chicken eggshells waste. Chicken eggshells contain 94% CaCO3 and can be used as a source of calcium to synthesize hydroxyapatite (Ca10(PO4)6(OH)2) by the precipitation method. Hydroxyapatite can be used as an adsorbent material because it has pores, inert, and wear-resistant so it can adsorb dissolved metal ions Cr (VI) contained in liquid waste from electroplating process. This research aims to synthesize hydroxyapatite from chicken eggshells and determine the optimum pH, contact time, adsorbent mass, and initial concentration of waste which influence the adsorption efficiency using continuous system column adsorption method with fixed flow rate 25 mL/min. In this study, the metal ions Cr (VI) was chosen as adsorbate because Cr (VI) is the main component in electroplating process. This research started from preparation of chicken eggshells waste then synthesized into hydroxyapatite and characterized using XRD, FTIR, and SEM that known structure formed adsorbent is hydroxyapatite and measuring the initial Cr (VI) concentration in waste using AAS with wavelength 357,9 nm. The result of optimizing are the optimum pH 5, contact time of 60 minutes, 3,5 gram of adsorbent mass, and the initial concentration of waste is 10 ppm. The analyzed were done for Cr (VI) concentration. The result showed 99,48% adsorption efficiency with final concentration of Cr (VI) is 0,07 ppm. The adsorption process followed the Freundlich isotherm model with maximum adsorption capacity of 3,93 mg/g hydroxyapatite.
Pancreatic Protection Effects of Butterfly Pea (Clitoria Ternatea) Flower Extract Against White Rattus Novergicus Induced By Alloxan
Authors: Temarwut Farid Fani , Prayitno Suprapto , Kamal Saenal Edi , Sari Skolastika Biana , Hartanti Evi Ayu
Published: October 2023

The pancreas is an endocrine gland that produces the peptide hormones insulin, glucagon, and somatostatin, and also an exocrine gland that produces digestive enzymes. These hormones play an important role in regulating the body's metabolic activities, especially blood glucose homeostasis. The aim of this study was to investigate the ethanolic extract of butterfly pea flower (Clitoria ternatea L) against white rats (Rattus novergicus) induced by alloxan and to I the level of its damage. Fifteen male wistar rats (150-200 g) body weight (BW) were divided into 5 groups. The control healthy group, the placebo group and the extract treated group that received 150 mg/kg BW (group I), 300 mg/kg BW (group II) and 450 mg/kg BW (group III) orally. Placebo (Na-CMC) and extract were given for 5 consecutive days before alloxan administration (150 mg/kg BW) on days 6 and 7. Blood samples were taken to determine the glucose and albumin levels on day 0 (before treatment), on day 5 (after treatment of the extract but before the administration of alloxan), and on 6 and 7 after 24 h administration of alloxan. Alloxan induced gives a significant increase in glucose and albumin levels. The average of glucose level was 236.6±37.6 mg/dl in the health control, 252±28.1 mg/dl in the placebo group, 137±35.5 mg/dl in the extract of group I, 115.9±19.1 mg/dl in the extract of 300 mg of group II and 145.2±58.6 mg/dl of group III. Meanwhile the average of albumin level in the healthy group was 3.39±0.8 g/dl, the placebo group was 2.7±0.2 g/dl, the group I was 1.9±0.04 g/dl, the group II was 1.77±0.16 g/dl, and the group III was 1.85±0.19 g/dl. This study showed that at highest dose of C. ternatea was able to significantly prevent the elevation pancreatic damage biomarkers and this finding was associated with the result of histopathological analysis of the pancreas. These results suggest that the ethanol extract of C. ternatea at a dose of 450 mg/kg BW (group III) has a good protective effect on the function and structure of pancreatic tissue.
Clean Water Demand Prediction Model Using The Long Short Term Memory (LSTM) Method
Authors: Sari Delviani Permata , Karlitasari Lita , Wihartiko Fajar Delli
Published: October 2023

Cities or districts as population centers with various service facilities, really need the provision of clean water. The agency that handles clean water in Indonesia is the Regional Drinking Water Company (PDAM). PDAMs were established in every city and district in Indonesia as agencies that serve the community's need for clean water. One of them is the Regional Public Company (Perumda) Tirta Pakuan and as time goes by the number of customers will definitely increase so that the need for clean water will also increase. The purpose of this research is to create a Clean Water Demand Prediction Model using the Long Short Term Memory (LSTM) Method to find the most optimal modeling. The data in this study were obtained from data reports is from Perumda Tirta Pakuan. The prediction model development process is carried out through Visual Studio Code tools. To find a model with the smallest error rate using various ratios, namely 80:20, 70:30, 60:40, and 50:50, then testing is also carried out based on the number of different hyperparameter values in batch sizes 5, 10, 15, 20, 25 and max epoch 50, 100, 150, 200, 250. From all the experiments that have been carried out, the most optimal is batch size 5 and epoch 50 with a ratio of 60:40 for water production to get RMSE 0.4862 and MAPE 2.5252% while for the amount of water use with a ratio of 50:50 get RMSE 0.4674 and MAPE of 2.5163%.
Cultural Property in Scotland: Exploring Cultural Nationalism and Beyond
Authors: Zhang Yudi
Published: October 2023

This article is divided into two main sections, exploring the ownership and disposition of Scotland’s cultural heritage through the lenses of the Treasure Trove system and the repatriation of looted artefacts. The former, grounded in the principle of bona vacantia, attributes unclaimed artefacts to the Crown as the representative of the nation, thereby contributing to the protection of national historical treasures through cultural nationalism. Furthermore, this paper elucidates the scope of the bona vacantia principle by examining the emblematic case of Lord Advocate v University of Aberdeen and Budge. It also assesses the practical implementation of Scotland’s Treasure Trove system, critically discussing the advantages and disadvantages of this comprehensive nationalization process. However, when addressing the repatriation of looted artefacts from the colonial era, it is necessary to transcend cultural nationalism. This article posits that a relational justice approach is more open and equitable, using the return of the Benin Bronzes as an exemplar. It discusses the repositioning of Scottish museums and the opportunity presented by artefact repatriation to foster cultural exchange with formerly colonized nations and the preservation of cultural heritage, under a methodology that emphasizes the inherent responsibility in the relationship between people and objects, as well as educational ethos.
In-Depth System-Level Energy Analysis of Hybrid Electrified Commuter Aircraft for Improved Energy Efficiency
Authors: Diamantidou Dimitra Eirini , Zaccaria Valentina , Kalfas Anestis
Published: October 2023

This work presents a comprehensive analysis of hybrid electric propulsion systems in commuter aircraft, aimed at enhancing energy efficiency. The study utilizes an aircraft conceptual design library, OpenConcept, to perform evaluations of various aircraft components and their interrelationships. The methodology integrates aerodynamics, propulsion, and mission analysis within a common framework to optimize the aircraft design. The analysis focuses on a 19-passenger commuter aircraft, employing a series/parallel hybrid-electric architecture. The gradient-based Sequential Least Squares Programming optimizer is utilized to optimize design variables such as battery weight, engine power, and the selected power ratios, while adhering to operational constraints. Through a rigorous Design of Experiments study, the paper highlights that even when considering the current battery technology, hybrid-electric propulsion yields substantial energy savings for short-haul missions. The fuel and energy consumption reductions are evident, particularly for shorter ranges. However, for extended missions, the critical role of advanced battery energy density is emphasized to achieve significant energy efficiency improvements.
A Python-based code for modeling the thermodynamics of the vapor compression cycle applied to residential heat pumps
Authors: Allen Rebecca , Svortevik Eirik , Bergersen Henrik
Published: October 2023

Heat pumps are an attractive heating system in residential buildings. They operate based on the vapor compression cycle used in refrigeration systems. Design questions surrounding heat pumps can be investigated and answered using modelling tools that incorporate the necessary thermodynamics, fluid mechanics, and machinery component efficiency. Several modelling tools are available, however there is a need for more open-source, script-based programs that are competitive to those already available. This work presents a Python-based code for modeling the thermodynamics of the vapor compression cycle (VCC) in typical heat pumps. The main contribution of this work is an openly available online code, complete with a few examples to show its functionality, that provides the basic thermodynamic model of a heat pump for researchers or development engineers to use, modify, and extend. Its current features include choice of refrigerant, heat exchanger size and characteristics, compressor, and other design parameters such as heating load, and fluid temperatures in and out of the heat exchangers. Simulation outputs include the P-h and T-s diagrams and coefficient of performance (COP). The code is flexible and suggestions for future code development are given.
Estimation of effluent nutrients in municipal MBBR process
Authors: Komulainen Tiina , Baqeri Abdul Malik , Nermo Einar , Keprate Arvind , Saltnes Torgeir , Jansen Katrine Marsten , Korostynska Olga
Published: October 2023

The recently updated European Union’s Urban Waste Water Treatment Directive proposal, European Green Deal, Biodiversity Strategy for 2030, and EU’s Energy System Integration highlight a pressing need for innovative biological nutrient removal processes and energy-efficient control methods to reduce pollution and minimize the carbon footprint at water resource recovery facilities. The aim of the PACBAL research project is to develop estimation methods for nutrient profile in a novel industrial Moving Bed Biofilm Reactor (MBBR) process. This study devises and assesses a range of data-driven methods to estimate effluent phosphorus concentration by utilizing a combination of real sensors with software models. The resulting virtual sensor could facilitate the design of energy-efficient control strategies. The case study data are collected from the MBBR process at Hias water resource recovery facility in Norway. Data sets from December 2022 to March 2023 include varying weather conditions, such as rain, dry, and snow. The Hias Process consists of three anaerobic and seven aerobic zones, where biomass carriers removes over 90 percent of the phosphorus from the wastewater in simultaneous biological processes. The industrial online measurements include wastewater flowrate, aeration rates, dissolved oxygen and nutrients COD and NO2/ NO3 at inlet and total suspended solids at outlet. Dynamic data-driven models indluding transfer functions, state-space models and ARX models, were developed and compared to estimate the outlet phosphorus concentration. Model fitness to validation data was around 7% with ARX models, and up to 18% with tranfer function models and state-space models. The first and second order models gave similar results. The state-space models will be developed further and implemented to into virtual sensors that will enable energy-efficient control strategy development.
Predicting the effects of spatiotemporal modifications of muscle activation on the tentacle extension in squid
Authors: van Leeuwen Johan L. , Kier William M.
Published: October 2023

Squid use eight arms and two slender tentacles to capture prey. The muscular stalks of the tentacles are elongated approximately 80% in 20–40 ms towards the prey, which is adhered to the terminal clubs by arrays of suckers. Using a previously developed forward dynamics model of the extension of the tentacles of the squid Doryteuthis pealeii (formerly Loligo pealeii), we predict how spatial muscle-activation patterns result in a distribution of muscular power, muscle work, and kinetic and elastic energy along the tentacle. The simulated peak extension speed of the tentacles is remarkably insensitive to delays of activation along the stalk, as well as to random variations in the activation onset. A delay along the tentacle of 50% of the extension time has only a small effect on the peak extension velocity of the tentacle compared with a zero-delay pattern. A slight delay of the distal portion relative to the proximal has a small positive effect on peak extension velocity, whereas negative delays (delay reversed along stalk) always reduce extension performance. In addition, tentacular extension is relatively insensitive to superimposed random variations in the prescribed delays along the stalk. This holds in particular for small positive delays that are similar to delays predicted from measured axonal diameters of motor neurons. This robustness against variation in the activation distribution reduces the accuracy requirements of the neuronal control and is likely due to the non-linear mechanical properties of the muscular tissue in the tentacle.
Acoustic-propelled micro/nanomotors and nanoparticles for biomedical research, diagnosis, and therapeutic applications
Authors: Mu Guanyu , Qiao Yu , Sui Mingyang , Grattan Kenneth T. V. , Dong Huijuan , Zhao Jie
Published: October 2023

Acoustic manipulation techniques have gained significant attention across various fields, particularly in medical diagnosis and biochemical research, due to their biocompatibility and non-contact operation. In this article, we review the broad range of biomedical applications of micro/nano-motors that use acoustic manipulation methods, with a specific focus on cell manipulation, targeted drug release for cancer treatment and genetic disease diagnosis. These applications are facilitated by acoustic-propelled micro/nano-motors and nanoparticles which are manipulated by acoustic tweezers. Acoustic systems enable high precision positioning and can be effectively combined with magnetic manipulation techniques. Furthermore, acoustic propulsion facilitates faster transportation speeds, making it suitable for tasks in blood flow, allowing for precise positioning and in-body manipulation of cells, microprobes, and drugs. By summarizing and understanding these acoustic manipulation methods, this review aims to provide a summary and discussion of the acoustic manipulation methods for biomedical research, diagnostic, and therapeutic applications.
Helicobacter pylori infection: a dynamic process from diagnosis to treatment
Authors: Sun Qifang , Yuan Chengzhi , Zhou Sainan , Lu Jing , Zeng Meiyan , Cai Xiong , Song Houpan
Published: October 2023

Helicobacter pylori, a gram-negative microaerophilic pathogen, causes several upper gastrointestinal diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer. For the diseases listed above, H. pylori has different pathogenic mechanisms, including colonization and virulence factor expression. It is essential to make accurate diagnoses and provide patients with effective treatment to achieve positive clinical outcomes. Detection of H. pylori can be accomplished invasively and noninvasively, with both having advantages and limitations. To enhance therapeutic outcomes, novel therapeutic regimens, as well as adjunctive therapies with probiotics and traditional Chinese medicine, have been attempted along with traditional empiric treatments, such as triple and bismuth quadruple therapies. An H. pylori infection, however, is difficult to eradicate during treatment owing to bacterial resistance, and there is no commonly available preventive vaccine. The purpose of this review is to provide an overview of our understanding of H. pylori infections and to highlight current treatment and diagnostic options.