bluuebunny/crossref_metadata_2025 huggingface dataset:
Enfermedad de Von Willebrand, revisión sobre una enfermedad hematológica frecuente y subdiagnosticada
Authors: Theran león Juan Sebastián , Dulcey Sarmiento Luis Andrés , Lobo Quintero Danuil , Esteban Badillo Laura Yibeth , Nariño Anaya Stephania Julieth , Díaz Calderón Paula Fernanda
Published: March 2023

Este es el trastorno hemorrágico hereditario más común, descrito por primera vez en las Islas Aland por Erik von Willebrand. Ocurre como resultado de una disminución en los niveles plasmáticos o un defecto en el factor de von Willebrand, que es una gran glicoproteína multimérica. Los monómeros de esta glicoproteína se someten a N-glucosilación para formar dímeros que se organizan para dar multímeros. La unión con las proteínas plasmáticas (especialmente el factor VIII) es la función principal del factor de von Willebrand. La enfermedad es de dos formas: formas heredadas y adquiridas. Las formas heredadas son de tres tipos principales. Son tipo 1, tipo 2 y tipo 3; en el que el tipo 2 se subdivide en 2A, 2B, 2M, 2N. El tipo 1 es más frecuente que todos los demás tipos. El sangrado mucocutáneo es leve en el tipo 1, mientras que es de leve a moderado en los tipos 2A, 2B y 2M. El tipo 2N tiene síntomas similares a los de la hemofilia. La fisiopatología de cada tipo depende de los defectos cualitativos o cuantitativos del factor de von Willebrand. El diagnóstico se basa en el antígeno del factor de von Willebrand, el ensayo de actividad del factor de von Willebrand, la actividad del coagulante FVIII y algunas otras pruebas adicionales. Los resultados deben analizarse dentro del contexto del grupo sanguíneo. El análisis del multímero del factor von Willebrand es esencial para tipificar y subtipificar la enfermedad. El manejo de la enfermedad involucra terapia de reemplazo, terapia de no reemplazo y otras terapias que incluyen antifibrinolíticos y agentes tópicos. El análisis del multímero del factor von Willebrand es esencial para tipificar y subtipificar la enfermedad. El manejo de la enfermedad involucra terapia de reemplazo, terapia de no reemplazo y otras terapias que incluyen antifibrinolíticos y agentes tópicos.
Metodología de intervención educativa para la atención de problemas sociales con integración de tecnología web 4.0
Authors: Aguirre Mejía Elena Tzetzángary , Parada Morado Lilia , Meraz Salazar Erika Alejandra , Rodríguez Campos Francisco Eduardo
Published: March 2023

El objetivo de la investigación es presentar una metodología para el desarrollo de una intervención educativa con tecnología Web 4.0, dirigida a estudiantes nivel secundaria, para atender problemas sociales es especial atención a los embarazos adolescentes. La metodología utilizada es investigación mixta, comparativa descriptiva con diseño metodológico de intervención educativa que integra tecnología web 4.0, presentada en seis fases, a) problema y temática para la intervención educativa, b) abordaje metodológico, c) proyecto de intervención educativa, d) aplicación de la intervención educativa, e) presentación de resultados, f) presentación de conclusiones. La intervención educativa es aplicada a un total de 5 escuelas secundarias con una muestra probabilística de 1647 estudiantes. Los resultados muestran la construcción, estructura y metodología para el desarrollo de una intervención educativa mediante la implementación de actividades, cronogramas, instrumentos y recursos con tecnología web 4.0.
El proceso penal abreviado frente al principio de no autoincriminación
Authors: Vega Curay Sandra
Published: March 2023

El presente artículo científico tiene como fin, efectuar un análisis sobre la vulneración del principio de no autoincriminación en el procedimiento abreviado, para ello se definieron los elementos teóricos del procedimiento abreviado, se demostraron las desventajas de este procedimiento así como también se describieron los derechos del procesado que son vulnerados. Para la materialización de esta investigación, se optó por el enfoque cualitativo, el cual permitió el análisis legal, jurisprudencial y doctrinario vinculado al procedimiento abreviado, por último se concluyó este procedimiento vulnera de manera directa derechos esenciales del procesado, como el principio de presunción de inocencia, el derecho que posea tener un juicio contradictorio, así como también el principio de no autoincriminación.
La importancia del arte en el desarrollo del niño
Authors: Villar-Cavieres Natalia , Castro Sandra
Published: March 2023

En las aulas educativas infantiles, el uso de los lenguajes no solo verbales, cada día toma mayor predominio y énfasis al momento de desarrollar las distintas estrategias pedagógicas. Es por ello, que la finalidad de esta investigación es presentar el cómo la disciplina de las artes o lenguajes artísticos impacta en la vida de niños y niñas, es decir, en su infancia. Se utilizó una investigación basada en la metodología cualitativa a través de la teoría fundamentada, ya que el propósito es poder entregar las distintas teorías, hechos, conceptos y fundamentación hacia el fenómeno real de esta investigación.  Por último, los resultados entregan que aún en las aulas educativas, el uso de los conceptos de arte o lenguajes artísticos queda en el mero trabajo de habilidades de carácter manual, dejando de lado lo kinestésico, oral, corporal, visual, dramatización e interpretación; aspectos tan importantes para el desarrollo integral de niños y niñas y el impacto que entrega a largo plazo en su quehacer en sociedad.
Libro compilatorio de resúmenes de investigación “Congreso Multidisciplinario Ciencia Latina – 2023”
Authors: ortega Rolando
Published: March 2023

Libro compilatorio de resúmenes de investigación “Congreso Multidisciplinario Ciencia Latina – 2023”
Membangun Ekosistem Kewirausahaan Digital Syariah Bagi UMKM di Wilayah Jawa Timur dan Nusa Tenggara Barat
Authors: Prasnowo M. Adhi , Muhajir Sulthonul Aziz  , Indrasari Meithiana , Eko Pamuji  , Dwi Prasetyo
Published: March 2023

Di era digitalisasi yang sekarang ini mempengaruhi perkembangan teknologi informasi yang terus berkembang, perkembangan teknologi berbasis digital semakin cepat dan canggih. Digitalisasi pola usaha dan ekonomi syariah masih menjadi tantangan dan peluang besar untuk diterapkan di Indonesia. Ekonomi dan pola usaha syariah dengan segala infrastruktur dan instrumennya harus mampu mengambil peluang yang sangat besar ini. Kesempatan emas ini harus dimanfaatkan dengan sebaik-baiknya oleh para penggiat ekonomi syariah. Sehingga perlu dilaksanakan program pelatihan  Digital Enterpreunership Academy (DEA) Kewirausahaan Digital Syariah dengan masyarakat sasaran di Jawa Timur dan Nusa Tenggara Barat. Program pelatihan dilaksanakan dengan susunan kurikulum yang relevan dengan masyarakat sasaran dengan metode pelatihan secara luring selama 2 hari dengan 13 Jam Pertemuan. Pelaksanaan Pelatihan Digital Enterpreunership Academy (DEA) Kewirausahaan Digital Syariah bagi pelaku usaha kecil menengah yang telah dilaksanakan dengan susunan kurikulum pertemuan mampu memberikan wawasan masyarakat sasaran untuk memulai pola syariah dan membentuk ekosistem wirausaha syariah agar sistem ekonomi semakin kuat. Hal tersebut dijelaskan bahwa 954 peserta menilai bahwa materi relevan dengan permasalahan-permasalahan yang dihadapi oleh peserta juga secara kemanfaatan pelatihan dapat dinilai memiliki tingkat keberlanjutan yang layak untuk terus dilaksanakan.
BIOREMEDIATION OF SEAFOOD PROCESSING PLANT EFFLUENT: COLLECTION AND BIOCHEMICAL ANALYSIS OF EFFLUENT
Authors: Rameshchandra Mehta Samixa , Vasantba Jadeja J.
Published: March 2023

Microorganism bioremediation of seafood processing plant wastewater is a viable alternative to the traditional effluent treatment technique of recovery and removal. Five seafood processing plants in and around Veraval were sampled for waste water. This water was transported to lab in controlled condition and were analysed for eutrophic component present and BOD, COD value evaluation. Soil samples from the same places were collected for bacterial isolation. From them over 40 bacterial strains were collected from five different seafood processing industry soil samples near Veraval.
USE OF CONCEPT MAPPING FOR TEACHING ECONOMICS
Authors: Parween Shahina , Parveen Shakera , Zaheer Afroz
Published: March 2023

Economics which is a social science, studies certain activities of the people living in the society. To make economics teaching practical and to awaken the sense of responsibility, it is necessary that the school should give students theoretical as well as practical knowledge, which may be linked to their day to day life. Many writers and economists lay stress on the practical aspect of economics teaching. The famous economist Marshall has written, “ The aims of study of economics are to gain knowledge for its own sake and to obtain guidance in the practical conduct of life and specially in social life.” Binning and Binning have written about the aims of economics teaching, “The aim of secondary school economics should be to teach modern economics principles by observation and through an understanding of current practices.” They further have written, “Pupils should be trained to apply sound economics theory to everyday life.” So, the teachers should adopt effective teaching strategies to improve the competency of students in the application of theory in the social setting. Concept mapping is one method of teaching that encourage students’ meaningful learning. By the time of the First International Conference on Concept Mapping in 2004, the application of concept mapping had been empirically evaluated for efficiency and effectiveness as a knowledge elicitation method ( Hoffman et al., 2002) and a method to solve problems in the workplace ( Freeman, 2004). This paper presents the theoretical framework and origin of concept maps and a sample lesson plan on “Organization of Production”.
PENGARUH PENGGUNAAN MEDIA BINGKAI 10 TERHADAP PEMAHAMAN PART-PART-WHOLE PADA ANAK USIA 6-7 TAHUN (STUDY EKSPERIMEN DI BKB PAUD ANGGREK KELURAHAN MUNJUL, KECAMATAN CIPAYUNG, JAKARTA TIMUR)
Authors: Sari Intani Dewi Kartika , Hapidin Hapidin
Published: March 2023

AbstrackThis study aims to obtain empirical data on the effect of Ten Frame Media usedto understand Part-part-whole in 6-7 Years old at in Munjul Village, Cipayung Subdistrict, East Jakarta.The method used is kuantitatif research with experiment approach and the research design is True Experimental with Two Group Pre-test and Post-test Design (technique of pre-test and post-test with two groups randomized).The population in this study were all students aged 6-7 years which is a group of early childhood in the Munjul Village. The sample in this study is children aged 6-7 years in early childhood education for School Readiness Group (KeMaS) with a sample of 15 children in the experimental group and 15 children in the control group, which was taken by using simple random cluster technique.Data collection tools of Variable Y (Part-part-whole Understanding) is done using techniques of observation checklist. The analysis technique used is the t-test for small samples are not correlated. Based on the results of  hypothesis testing using t-test is obtained price thitung1 = 22, 5 (comparative test of pre-post test Experimental Group), thitung2 = 8, 90 (Comparative test of pre-post test control group), and thitung3 = 30, 79 (Comparative test of post-post-test Experiment-Control Group), a price table = 1, 70, and dk = 28 at the significant level ? = 0.05. From these results it can be concluded that thitung ttable, so this study reject H0 (Zero Hypothetical) and receiving Ha (Alternative Hypothesis). This study therefore implies that the use of 10 frames media significant effect on the understanding part-part-whole in children aged 6-7 years. The more often a child at the age of 6-7 years using the media frame 10, then the better the understanding of the part-part-whole. Keywords: Ten Frame Media, Counting Principles, Part-part-whole
KEMAMPUAN BERBICARA ANAK USIA 3-4 TAHUN DI KELUARGA MULTIETNIK (STUDI KASUS DI KECAMATAN DUREN SAWIT, JAKARTA TIMUR)
Authors: Putri Wara Dwi , Hapidin Hapidin , Akmal Yenina
Published: March 2023

AbstrackThis qualitative research is to find out and describe The Speaking Ability of 3-4 years old in Multiethnic Family, Duren Sawit, East Jakarta. The subject of this research is a child of 3-4 years old who is in a multiethnic family environment. Collecting data by observation, interview, and documentation. In this research using case study method, with Creswell analysis data techniques. The method consists of description and theme findings, interrelating theme, and interpreting the meaning of theme. The research findings that the ability to speak in children aged 3-4 years is seen in (1) the process of acquiring new vocabulary that occurs due to the interaction carried out by children with family and friends in their home environment, (2) the ability of children to use a variety of languages such us language English, Spanish, and Indonesian when speaking, (3) Disclosures sentences spoken by children already look right for obvious reasons, and (4) Factors for the formation of children's speaking abilities, where children are given freedom and proper direction in adapting to the environment her home. Keyword: Speaking Ability, Multiethnic Family, Children 3-4 Years Old
HUBUNGAN POLA ASUH DEMORKATIS ORANG TUA DENGAN PERILAKU MORAL ANAK USIA 4-6 TAHUN
Authors: Zuhra Lutfiah , Hapidin Hapidin
Published: March 2023

This study aims to determine the relationship of democratic parenting parents with the moral behavior of 4-6 years old children. This research was conducted in Lenteng Agung Village, South Jakarta. The sample in this study were parents who have children aged 4-6 years who attend school in Lenteng Agung Village, South Jakarta as many as 30 people. This research was using cluster simple random for the sampling technique. The method used is the correlation method. Data was collected by distributing questionnaires in the form of questionnaires. From the calculation results of the Pearson Product Moment correlation test, the results of the person correlation r are 0.378 and  are 0.361 with a significant level = 0.05 and n is 30. From the results of data analysis, it can be concluded that there is a significant positive relationship between parenting democratic parents with the moral behavior of 4-6 years old children in Lenteng Agung Village, South Jakarta. Keywords: democratic parenting of parents, moral behavior
PENGGUNAAN METODE MONTESSORI DALAM KEGIATAN MENULIS DI PAUD
Authors: Nadar Wahyuni , Wijaya Purwani Kusumawati
Published: March 2023

Penelitian  ini  dilakukan  berdasarkan  temuan  masalah  yang  berkaitan  dengan kemampuan  menulis  anak  di  PAUD.  Permasalahan tersebut  menuntut  perlunya  suatu  pendekatan,  metode  atau  model  pembelajaran untuk  menanganinya.  Pembelajaran  yang  dikembangkan  adalah  pembelajaran melalui metode Montessori. Menulis untuk anak usia dini merupakan suatu permasalahan klasik yang menjadi catatan khusus untu orang tua dan guru. Dalam menulis, anak tidak hanya dituntut untuk memiliki kematangan di aspek Bahasa, tetapi harus siap di aspek perkembangan motorik halus dan juga kognitif, Metode Montessori merupakan salah satu metode menulis yang dapat diterapkan di PAUD karena metode ini dapat terintegrasi ke semua aspek, memiliki media yang menarik dan langkah-langkah yang mudah. Tujuan   penelitian   ini   adalah   memperoleh   gambaran   mengenai   penggunaan metode  Montessori  dalam  meningkatkan  kemampuan  menulis  anak  usia  dini  di PAUD. Penelitian  ini  menggunakan  metode  kualitatif.   teknik   Pengumpulan   data   dalam   penelitian   ini   melalui   observasi, wawancara, dan dokumentasi Keyword: menulis, anak usia dini, metode Montessori.
Foreign bank penetration in Vietnam following Vietnam’s accession to the WTO: matching expectations with reality
Authors: Thu Huong Pham , Xuan Vinh Vo , Thi Hien Nguyen , Thi Ly Bui , Ngoc Toan Nguyen
Published: March 2023

Vietnam continuously liberalizes the financial market as a requirement for its accession to the World Trade Organization in 2007. This paper discusses the foreign investors’ expectation and their experience when penetrating into Vietnam’s market. The role of the foreign entrants is also assessed. By synthesizing and analyzing relevant research and reports, several important insights are discovered. Firstly, the presence of foreign investors and banks improves market competition, efficiency, and stability. Wholly and partly foreign-owned banks provide the spillover effects in management quality, in the introduction of world standard banking products and services, and in the application of information technology. Secondly, by looking into the foreign owned banks, it is found that the banks’ foreign investors are not likely to play an influential role in managing the banks they invested in. The motive of the investors to control the invested companies leads to their decision of holdings withdrawing.
Solved at last: The Philippine endemic Psychotria philippensis is a synonym of Scyphiphora hydrophylacea (Rubiaceae, Scyphiphoreae)
Authors: Berger Andreas
Published: March 2023

Psychotria philippensis (Rubiaceae) was described by Chamisso and Schlechtendal in 1829, was the first Psychotria name published for the Philippines and is currently considered a Philippine endemic. The name remained in a taxonomic limbo for almost two centuries as it was variously accepted, synonymized or considered obscure, probably because the type specimen in the Berlin herbarium was destroyed and no original material has survived or is currently known. A combined analysis of the information on morphology, type locality and ecology contained in the protologue and a review of relevant literature on the study of the name by various authors over the last two centuries finally clarified the identity of P. philippensis. The name is confirmed here as a synonym of the rubiaceous mangrove Scyphiphora hydrophylacea, as first proposed by Schumann, one of the authorities of the family in the late 19th century, and the application of P. philippensis is fixed by neotypification. This reduces the number of Philippine species of Psychotria by one, but fortunately, this is not happening through extinction, as has been the case with too many species of the highly endangered Philippine flora. In addition, the history of the discovery and study of S. hydrophylacea and its synonyms are described in detail, and one lectotype and one neotype are designated.
Microdous amblyrhynchos sp. nov., a new member of the small-toothed sleepers (Teleostei, Gobiiformes, Odontobutidae) from Guangxi, southern China
Authors: Hu Jiantao , Lan Chun , Li Chenhong
Published: March 2023

Microdous amblyrhynchos, a new species, the second one in the genus, from the family Odontobutidae, is described from the Hongshui River, in the upper reaches of the Xijiang River of the Pearl River drainage, Baise City, Guangxi Zhuang Autonomous Region, southern China. This species is distinguished from its only congener, M. chalmersi, by the blunt snout (vs. pointed); mean snout length/head length ratio 0.27 (vs. 0.3); eye not extending outward (vs. protruding); mean interorbital width/head length ratio 0.25 (vs. 0.11). Additionally, the results of molecular phylogenetic analysis confirmed that M. amblyrhynchossp. nov. is distinct from its sister species, M. chalmersi.
Chapitre 1. La télémédecine et ses implications sur la relation médecin/patient
Authors: Zaouaq Karim
Published: March 2023

La pratique de la télémédecine est susceptible de soulever des problèmes éthiques et juridiques qui affectent la relation médecin/patient. De ce fait, le respect des principes éthiques s’avère nécessaire. C’est également le cas de l’implication du législateur. Ce dernier doit édicter des instruments spécifiques, capables de cerner toutes les problématiques induites par la télémédecine et de contribuer à une certaine humanisation de la relation médecin/patient.
Chapitre 4. La « démocratie Internet », une disparition sociale des corps ?
Authors: Colon David
Published: March 2023

L’article aborde l’impact de la numérisation de la vie politique sur la place des corps dans la vie politique et sociale des démocraties libérales. L’auteur entend montrer que la promesse d’une disparition des corps de l’espace public ne s’est que partiellement réalisée, et que le « capitalisme de surveillance » a au contraire donné une vigueur toute nouvelle à de nouvelles formes de mobilisations caractérisées par l’instrumentation des corps à des fins politiques.
États-Unis : le débat de Grande Stratégie
Authors: Shifrinson Joshua , David Dominique
Published: March 2023

La fin de l’ère unipolaire, avec la montée en force de la Chine et l’échec des engagements extérieurs américains, ouvre aux États-Unis le débat sur la Grande Stratégie à adopter dans un monde à nouveau saisi par la compétition des puissances. La discussion oppose trois écoles majeures : celle de l’« idéalisme de l’ordre libéral », celle de l’« hégémonie illibérale » et celle de la « retenue ». Le débat reste largement ouvert car le pays n’en est qu’au début de l’ajustement stratégique.
Managing consensus based on community classification in opinion dynamics
Authors: Zhang Yuntian , Chen Xiaoliang , Huang Zexia , Li Xianyong , Du Yajun
Published: March 2023

Opinion dynamics in social networks are fast becoming an essential instrument for concentrating on the effect of individual choices on external public information. One of the main challenges in seeing the dynamics is reaching an opinion consensus acceptable to managers in a social network. This issue is referred to as a consensus-reaching process (CRP). Most studies of CRP focus only on network structure and ignore the effect of agent opinions. In addition, existing methods ignore the diversities between divided communities. How to synthesize individual opinions with community diversities to solve CRP issues has remained unclear. Using the DeGroot model for opinion control, this paper considers the effects of network structures and agent opinions when dividing communities, incorporating community classification and targeted opinion control strategies. First, a community classification enhancement approach is utilized, introducing the concept of ambiguous nodes and their division methods. Second, we separate all communities into three levels, $ Center $, $ Base $, and $ Fringe $, according to the logical regions for opinion control. Third, an edge expansion algorithm and three opinion control strategies are proposed based on the community levels, which can significantly reduce the time it takes for the network to reach a consensus. Finally, numerical analysis and comparison are given to verify the feasibility of the proposed opinion control strategy.
Et cela est passé en nous
Authors: Prieur Jean-Marie
Published: March 2023

Questo testo rende omaggio ai lavori di Andrée TABOURET-KELLER. In riferimento ad essi e articolato sulle nozioni di Reale, Simbolico e Immaginario, esplora l’influenza dell’umano sul linguaggio, fra “lingua materna” e “lingua straniera”.
Andrée et le GEPE
Authors: Truchot Claude
Published: March 2023

Per trent’anni, fin dalla sua creazione negli anni ’90, Andrée non ha mai smesso di portare prima il suo sostegno, poi la sua piena partecipazione al GEPE (Gruppo di studio sul plurilinguismo europeo), gruppo di ricerca dell’Università di Strasburgo. Collaborando attivamente alle sue manifestazioni (seminari, giornate di studio, commissioni di tesi o di abilitazioni alla ricerca), nonostante i suoi numerosi impegni, è sempre stata umanamente curiosa nei confronti dei ricercatori alle prime armi o confermati che vi ha potuto incontrare.
Mon parcours de vie plurilingue
Authors: Sall Tikam
Published: March 2023

La giovane autrice (24 anni) usa ogni giorno francese, tedesco e inglese, a seconda del paese, del contesto e delle circostanze. Si comporta allo stesso modo anche in questa testimonianza. Tramite il suo trilinguismo, cui si aggiungono wolof, afrikaans, neerlandese e perfino un assaggio dei click languages dell’Africa meridionale, penetriamo nella sua vita plurilingue nei vari paesi in cui è cresciuta, ha studiato, è vissuta, ha lavorato : Francia, Germania, Paesi Bassi, USA, Senegal, Sudafrica, dove attualmente lavora nel quadro di un master di ricerca in studi africani.
Vous avez dit « panosse » ? ou : Les mots « pierre de patience »
Authors: Renard Maryse
Published: March 2023

Con il tempo e l’esperienza, l’autrice ha “preso coscienza delle parole”, di cui dice che occorre diffidare. Non solo perché sono strumenti di manipolazione perversa, perché possono mentire a causa d’un uso maldestro o volontario, ma piuttosto perché deformano insidiosamente il nostro sguardo, ci impongono un’immagine del mondo e ci rinchiudono, quasi a nostra insaputa, in un’identità obbligata e idee preconcette. Il che non preclude l’umorismo !
Paradigm
Authors: Jayasuriya Nisha
Published: March 2023

This chapter aims to provide a simple but a complete idea about the difficult concepts in the research field. Research paradigm is a concept which is difficult for new researchers to understand and memorize. This chapter covers the key concepts in the research paradigm: ontology, epistemology, and methodology. Researchers can understand these concept and decide the best paradigm to investigate different phenomena. To make these difficult concepts simple, this chapter has been organized with brief explanations and graphs.
Pragmatism and Non-Native English Speakers
Authors: Nagendrakumar Nagalingam , Madhavika Naduni
Published: March 2023

The debate of application of research philosophy in social science research is trending. One side takes the positivism while another side depends on interpretivism, some other believes critical realism and the rest stand with pragmatism. Yet, the understanding on and interpretation of ontological argument and epistemological positioning of the pragmatism is criticized. Accordingly, the authors are motivated to critically argue that gap with empirical research evidence from management disciplines in Sri Lanka. The pragmatism followers contend that all beliefs, knowledge, and scientific concepts are provisional and defined by their practical application in ongoing experience, not by their correspondence with antecedent truth or reality (Carlsen and Mantere, 2007). Hence, recent social sciences studies are rooted in pragmatic ideas, practice-based approaches thereby harvesting the intersubjective knowledge. Thus, this chapter acknowledges the paradox of whether the definition of pragmatism could be universal or differs contextually research scholars.
An Overview of Structural Equation Modeling and Its Application in Social Sciences Research
Authors: Pagadala Sai Priyanka , V. Sangeetha , P. Venkatesh , Jha Girish Kumar
Published: March 2023

Social science research deals with the highly complex phenomenon guided by various latent and interrelated constructs. As these constructs are invisible and not directly measurable, social scientists employ highly sophisticated multivariate analytical techniques that can simplify a complex data pattern to derive meaningful conclusions. Structural equation modeling (SEM) is a methodology used to represent, estimate, and test a network of relationships among variables. It is an integrated model for hypothesis testing and constructs' validity. This chapter deals with the various aspects of the SEM methodology, starting from describing the statistical algorithms used, the role of theory, measurement and structural model, stages in testing model validity, etc., meticulously explained in simple terms to provide with a basic understanding of this intricate technique.
Scientific Publication Guide for Non-Native English-Speaking Researchers
Authors: Moez Ltifi
Published: March 2023

Scientific publication is an essential aspect of technical, medical, social, economic, and other progress. New advances in human knowledge in any field are communicated to the rest of the world through publications. Scientific research is universal, so it is essential that this communicated knowledge is accurate, valid, reproducible, and practically useful. Researchers and scientists dream of publishing their work in high impact journals. To make these dreams come true, it is essential to learn, follow, and know the basic principles of research methodology and scientific publication. In this chapter book on the basis of the author's experiences and knowledge, the author presents a personal opinion on how to publish a chapter book in a high impact journal. The author talks about how to carry out good research, the design of the manuscript preparation, the respect of the editorial policy of the journal, the likely results, and the reasons for failure or success. The author provides the competitive weapons of publication in the form of advice, recommendations, and explanations, in order to achieve scientific success.
An Advanced Entropy Measure of IFSs via Similarity Measure
Authors: Talukdar Pranjal , Dutta Palash
Published: March 2023

The Entropy measure of an intuitionistic fuzzy set (IFS) plays a significant role in decision making sciences, for instance, medical diagnosis, pattern recognition, criminal investigation, etc. The inadequate nature of an entropy measure may lead to some invalid results. Therefore, it is significant to use an efficient entropy measure for studying various decision-making problems under IFS environment. This paper first proposes a novel similarity measure for IFS. Based on the proposed similarity measure, an advanced entropy measure is defined with a different axiomatic approach. This axiomatic approach allows us to measure an IFS's entropy with the help of a similarity measure. To show the efficiency of the proposed similarity measure, a comparative study is performed with the existing similarity measures. Some structural linguistic variables are taken as examples to show the validity and consistency of the proposed entropy measure along with the existing entropy measures. Finally, based on the proposed entropy measure, a multi-criteria decision-making problem is performed.
A Meta-Analysis of Facebook-Assisted Learning Outcomes in Different Countries or Regions
Authors: Yu Liheng , Xu Wei , Sukjairungwattana Paisan , Yu Zhonggen
Published: March 2023

In this special pandemic time, many learners have been forced to stay at home receiving education through mobile learning applications and social media such as Facebook. It is thus meaningful to meta-analytically review the studies on Facebook-assisted learning outcomes in different countries or regions to provide constructive suggestions for improvements on mobile learning. Through a meta-analysis using Stata 14.0, this study concludes that the Facebook-assisted learning approach may improve learning interaction, learning performance, social presence, engagement, psycho-motor, and overall skills in different countries or regions, although there are still different results and even controversial issues. The controversies lie in different findings in Taiwan, Switzerland, and UK, where no significant results are revealed regarding the use of Facebook for educational purposes. Future research could examine the construction of a sustainable online learning model, the classic theory, gender differences, and other mobile applications.
Multidisciplinary Educational Design Framework to Facilitate Cross-Boundary Educational Design
Authors: Selhorst-Koekkoek Mirjam , Rusman Ellen
Published: March 2023

The development of multidisciplinary education requires people to communicate, learn, and design beyond the boundaries of their own domains. In this research, an education design framework is developed to facilitate and support university teachers in multidisciplinary educational design. In addition, it serves as an aid to potentially transform domain-specific action-oriented knowledge into domain-integrated action-oriented knowledge by supporting knowledge co-construction across domain boundaries. The educational design framework, grounded in seamless and hybrid learning paradigms and theory on wicked problem solving, is being developed in a design-oriented educational research. This resulted in a multidisciplinary educational design game, which aims to facilitate cross-border communication, knowledge co-construction, and educational design processes during multidisciplinary educational design and improve the quality of the resulting multidisciplinary educational design.
Protocol for double-blinded randomized trial to enhance postural control after anterior cruciate ligament reconstruction by balance training and concurrent cognitive demands or external focus of attention
Authors: Tayebi Abdollah , Kouhzad Mohammadi Hossein , Nassadj Gholamhossein , Mehravar Mohammad
Published: March 2023

Anterior cruciate ligament (ACL) injury is one of the most common injuries among athletes that lead to postural control disorders. The aim of this study is to compare the effects of balance training with and without cognitive task and external focus of attention on postural control in individuals with ACL reconstruction. Sixty participants with ACL reconstruction, between the ages of 18 and 47 will be randomly allocated to three group’s including routine balance training, balance training with external focus of attention. Patients will be assessed at the baseline, after receiving eight weeks of intervention, and four weeks later. A double-blinded design will be used. Center of pressure data acquired from a forceplate will be used to assess amount and velocity of sway, local dynamical stability, and global stability of upright balance. Also, dynamic balance will be assessed using Star Excursion balance test. The results of this research will be used to establish effectiveness of treatment strategies for postural control in individuals with anterior cruciate ligament reconstruction. The suggested interventions would be clinically applicable in the athlete with ACL injury.
Immune-related Giant Cell Myocarditis after Immune Checkpoint Inhibitor Therapy in a Patient with Urothelial Carcinoma and Myasthenia Gravis
Authors: Chiu Chun-Chih , Guo Jhe-Cyuan
Published: March 2023

Immune-related adverse events (irAEs) have drawn global attention after the extended use of immune checkpoint inhibitors (ICIs) in the past decade. These inflammatory side effects hinder cancer treatment and potentially have a negative impact on the prognosis. Myocarditis is an infrequent but often life-threatening irAE, and the pathogenesis remains unclear owing to its rarity and fulminant nature. We present a case of immune-related giant cell myocarditis after pembrolizumab treatment for unresectable urothelial carcinoma of the bladder in a patient with underlying invasive thymoma and myasthenia gravis. This unusual presentation highlights the complexity of immune crosstalk in patients with autoimmune diseases who receive ICI therapy. Further, investigations and individualized treatment for this population are warranted to minimize toxicity.
Ewing's Sarcoma of the Small Intestine with Liver Metastasis Mimicking Gastrointestinal Stromal Tumor
Authors: Chen Po-Yi , Li Wan-Ting , Hsu Chih-Hung , Chen Tom Wei-Wu
Published: March 2023

Ewing's sarcoma (ES) is the second most common primary bone malignancy of childhood, whereas extraosseous ES (EES) is more common in older patients. EES of the small intestine is an extremely rare disease. We present a case of ES of the small intestine with liver metastasis mimicking a gastrointestinal stromal tumor. The diagnosis of ES requires a combination of histological, immunohistochemical, and molecular techniques. Further studies to investigate whether multimodality treatments can improve the survival of metastatic EES are needed.
Frontline Autologous Stem Cell Transplantation in POEMS Syndrome with Pulmonary Arterial Hypertension
Authors: Li Po-Hsien , Lin Hsin-Chen
Published: March 2023

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin change (POEMS) syndrome is a rare para-neoplastic syndrome related to plasma cell disorder. Pulmonary arterial hypertension (PAH) is a cardiovascular comorbidity caused by underlying plasma cell disorder. Targeted therapy aimed at plasma cells may be more beneficial than treating POEMS syndrome with conventional PAH therapy. We present the case of a 47-year-old woman who was diagnosed with POEMS syndrome complicated with PAH and treated with myeloma-like therapy followed by autologous stem cell transplantation (ASCT). This case highlights that targeted therapy against plasma cells and frontline ASCT may be beneficial with regards to the clinical outcomes.
Multiple Immunosuppressants for Immune-related Acholia in a Patient with Metastatic Colorectal Cancer
Authors: Chen Ching-Tso , Liang Yi-Hsin , Hung Chien-Wen , Yeh Kun-Huei
Published: March 2023

Immunotherapy-related adverse events (irAEs) such as hepatitis or cholestasis have been well recognized. In contrast, acholia was not previously reported as an irAE with a lack of standard treatment. We presented a case of a 68-year-old man with metastatic colon cancer that progressed after several chemotherapy sessions with targeted agents. He received nivolumab plus regorafenib (REGONIVO) as salvage treatment. However, he reported clay-colored stools and jaundice after 3 months of REGONIVO treatment. Computed tomography (CT) revealed no significant biliary tract dilation. Laboratory tests ruled out viral hepatitis or autoimmune hepatitis. Endoscopic retrograde cholangiopancreatography showed multiple filling defects of blood clot formation, and endoscopic retrograde biliary drainage was ineffective. An irAE presenting as acholia and hyperbilirubinemia was diagnosed. Subsequently, the patient was initially administered a corticosteroid only, with an equivalent dose of prednisone (1 mg/kg/day); however, this treatment had only limited effect. After the addition of multiple immunosuppressants, including mycophenolate mofetil and tacrolimus, the severity of hyperbilirubinemia declined and acholia was resolved. This case demonstrated that irAEs can present as acholia and hyperbilirubinemia without significant biliary obstruction. Although the mechanism of such an unusual irAE remains unclear, it seems to be refractory to corticosteroid treatment alone. A more aggressive strategy, such as multiple immunosuppressants, may be advisable.
Real-world Evidence of Daratumumab-Lenalidomide-Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients
Authors: Chiu Ling-Jung , Kuo Chin-Yuan , Ma Ming-Chun , Liao Chun-Kai , Liu Hung-Lin , Wang Ming-Chung
Published: March 2023

Background:

Daratumumab (DARA) introduced in the multiple myeloma (MM) treatment strategy, producing a direct antitumor activity and immunomodulatory effects in phase I-II trial GEN501. In the POLLUX trial, the combination of DARA with lenalidomide and dexamethasone (DRd) reported impressive response rates. In Taiwan, the Dara-based regimen was supported by National Health Insurance recently, but there were no real-world data in Taiwan.

Materials and Methods:

We described a heavily pretreated group of 31 patients with MM who had received one or more lines of therapy to receive DRd therapy after Taiwan Food and Drug Administration approval. The primary end point was progression-free survival (PFS).

Results:

After a median follow-up of 22.87 (95% confidence interval [CI]: 16–29.73) months, the median time to first response was 59 days (95% CI: 24.8–81.6). Median PFS was 24.082 months (95% CI: 14–33) in patients who received DRd therapy. Twelve-month PFS showed 80.7% in the DRd group. Patients who achieved at least very good partial response (VGPR) had longer median PFS (39.8 months) than those who achieved partial response (7.35 months). The complete response rate and VGPR were 35.5% and 29%, respectively. About 22.6% of patients had a partial response. The average treatment duration was 11.48 ± 7 months. Patient experienced biological relapse at 5.88 months after discontinuing DRd treatment.

Conclusion:

After DRd treatment for 11.48 months, most of the patients showed biological relapse at 5.88 months, suggesting the good efficacy; however, the need of a longer maintenance treatment of DARA. The median PFS in real-world setting was consistent with the POLLUX trial regardless of more patients with high cytogenetic risks. Patient who could achieve deep response above VGPR had better PFS than those who did not.
Effect of integration of two bacterial bioagents and a plant residue extract for biocontrolling root-knot nematode, Meloidogyne incognita infesting potatoes
Authors: El-Nagdi Wafaa M.A. , Youssef Mahmoud M.A. , Abd-El-khair Hassan , Elkelany Usama S. , Abd-Elgawad Mahfouz M.M. , Dawood Mona G.
Published: March 2023

Background

Recently, there has been an increasing attempt to explore nature-friendly compounds that could be substitutes for chemically synthesized products. It was found that some plant residues and certain microorganisms, including antagonistic bacterial species such as Bacillus spp. associated with plants, can act as biocontrol agents, achieving various degrees of control against Meloidogyne incognita, as well as increasing the plant growth and yield parameters.

Objectives

This research was designed to study the effect of Bacillus subtilis (Bs) and B.
pumilus (Bp) alone or in combination with pomegranate peel aqueous extract (PP) on root-knot nematode, M. incognita, infesting potato cv. Spunta, as well as to examine the biochemical changes and total microbial counts under field conditions.

Materials and methods

Overall,100 g of crushed pomegranate fruit peel (PP) water extract and two bacterial biocontrol agents were applied in a field experiment for controlling root-knot nematode, M. incognita. These bacteria, B. subtilis (Bs) and B. pumilus (Bp), were isolated from rhizosphere soil and identified according to standard microbiological characteristics. In a field naturally infested with M. incognita, potato cv. Spunta tubers were planted during winter growing season. After planting, each of the bacteria was added in the soil at the tested rate (107–109 CFU/ml). Moreover, some tubers that were planted in the soil served as untreated control. The treatments included (a) B. subtilis (Bs)+pomegranate peel (PP) residue extract, (b) B. pumilus (Bp)+PP residue extract, (c) PP residue extract+medium (M), (d) Bs, (e) Bp, (f) PP residue extract, (g) medium (M), and (h) untreated control.

Results and conclusions

Based on the percentages of juvenile reduction in soil at the harvest time, Bs+PP recorded 84.0% juvenile reduction followed by Bp+PP (82.3%), revealing combined treatments to be more effective than single treatments (78.4% by Bs and 72.8% by Bp). The examination of co-toxicity of the two applied combined treatments at the harvest stage showed synergistic effects. All treatments significantly (P≤0.05) increased plant growth and yield criteria, especially individual treatments. Biochemical compounds and the total bacterial and fungal counts in potato rhizosphere varied with different treatments. It could be concluded from the present study that the combined treatments of B. subtilis or B. pumilus +PP inhibited M. incognita proliferation in potatoes more than single treatments. However, single treatments improved plant growth and yield more than the combined cases. Biochemical changes and microbial counts of potatoes were influenced by different treatments.
Evaluation of chronic post-inguinal herniorrhaphy pain in patients receiving ultrasound-guided ilioinguinal and iliohypogastric nerve block with lidocaine (5%) patch
Authors: Faiter Aliaa A. , Mansour Magdy Abd El-Aziz , Hozien Adel Ibrahim
Published: March 2023

Aim

To assess the efficacy of preemptive analgesia in the form of ultrasound-guided (IIN / IHN) block alone or with lidocaine (5%) patch on (US) acute, chronic post-herniorrhaphy pain and patient satisfaction.

Patients and methods

Preemptive US guided IIN / IHN block was performed on 60 patients (equally distributed into two groups) planned to undergo unilateral inguinal hernia operation under general anesthesia, 30 patients without lidocaine (5%) patch (group I) and 30 patients with lidocaine (5%) patch in the postoperative day 0 (group II). The groups were compared regarding patient satisfaction, intensity of postoperative pain, chronic post-herniorrhaphy pain, and its impact on daily activities.

Results

There were considerable differences between two groups as regards Douleur Neuropathique en 4 questions as it was higher in group I, P value less than 0.001. There was a significant increase in Brief Pain Inventory short form score postoperatively through 1, 3, and 6 months in group I, P value of 0.033. On the other hand, there were insignificant differences within each group as regards Brief Pain Inventory at 1, 3, and 6 months postoperatively with P values of 0.378, 0.931, and 0.934, respectively. There were insignificant differences regarding the patient’s satisfaction and postoperative visual analog scale.

Conclusions

US guided IIN / IHN block provides good perioperative pain control for inguinal hernia-repair surgeries. Addition of lidocaine (5%) patch may increase patient satisfaction and improve chronic postoperative pain outcome.
The effect of adding verapamil to local anesthetics in peribulbar block for intraoperative anesthesia and postoperative analgesia in vitreoretinal surgery
Authors: Aboul Fetouh Iman S. , Khattab Rehab S. , Salem Abeer S. , Naguib Nader N. , Omar Tamer
Published: March 2023

Aims

To evaluate the efficacy and safety of verapamil as an adjuvant to the local anesthetics xylocaine and bupivacaine for peribulbar block in vitreoretinal surgery.

Settings and design

This blinded, randomized, controlled trial was carried out at the Research Institute of Ophthalmology, Egypt.

Patients and methods

A total of 82 eligible patients were randomly allocated into two groups. The control group received xylocaine, bupivacaine, and normal saline. Verapamil group were treated the same way as the control group but received 5 mg of verapamil instead of normal saline. The primary outcomes included the onset of sensory block, motor block, lid akinesia, duration of the block, and patients’ hemodynamics. Secondary outcomes included postoperative pain, time to first analgesia, and patient’s and surgeon’s satisfaction.

Results

The onset of sensory block was significantly shorter in the verapamil group compared with the control group (42.6±10.1 vs. 52.2±23.6 s, respectively; P=0.020). A significant decrease in the mean rank of VAS score was recorded at two h in the verapamil group compared with the control group (30.72 vs. 47.50, respectively; P=0.001). Otherwise, the medians of motor block and lid akinesia and the mean duration of block did not show significant differences between the two groups.

Conclusions

Addition of 5 mg of verapamil to a mixture of 5 ml of xylocaine 2% and 5 ml of bupivacaine 0.5% in peribulbar block significantly shortened the onset of sensory block and reduced the postoperative pain but did not affect the onset of motor block or the duration of anesthesia.