bluuebunny/crossref_metadata_2025 huggingface dataset:
RHEOLOGICAL, IMMUNOLOGICAL AND MICROBIOLOGICAL
PARAMETER DYNAMICS AFTER DENTAL IMPLANTATION
Authors: Yarov Yuriy Yu.
Published: October 2020

Introduction: It has been proven that the oral hygiene is determined by the quantitative and qualitative composition of the bacterial biofilm, by the local immunity, and the
rheological properties of the oral fluid.
The aim of this study was to observe the dynamics of these parameters in the short term postoperative period after dental implantation in patients with a different state of
periodontal tissues, depending on maintenance therapy.
Materials and methods: 124 healthy people, aged 18 to 34, were examined. Depending on the follow-up maintenance therapy after dental implantation, patients were divided into two equal study groups:
patients of the main group received the proposed differentiated maintenance therapy, the volume and multiplicity of which were determined by the initial oral hygiene state; patients of the control group
underwent traditional treatment. Patients with healthy periodontium comprised a comparison group. Using the digital drop shape, the viscosity coefficient b2 was determined. Identification of the biofilm’s
microorganisms was carried out with aerobic and anaerobic cultivation techniques. The presence of immunoglobulin SIgA in the oral liquid was determined by Manchini’s radial immunodiffusion method.
Results: In the main group, the viscosity coefficient b2 and the content of SIgA immunoglobulin in the oral fluid were significantly higher than in the control group (p <0.05).
The proposed maintenance therapy led to the restoration of the species domination of the probiotic microflora, proportional to the healthy periodontium both in the frequency
of selection, and the level of insemination. The indicated dynamics of these parameters leads to a probable decrease of the Green-Vermillion HI (p<0,05).
Conclusions: Proposed maintenance therapy leads to a probable improvement of the oral hygiene state based on Green-Vermillion HI, caused by the normalization of the
surfactant properties of the oral liquid, biofilm’s ratio of microbial associations, and local oral hygiene.
MORPHOLOGICAL AND PHYSIOLOGICAL, BIOLOGICAL AND
EPIDEMIOLOGICAL FEATURES OF ACARIANA OF THE GENUS
IXODES (LATREILLE, 1795) - HUMAN ECTOPARASITES IN
BIOGEOCENOSES OF TERNOPIL REGION
Authors: Fedoniuk Larysa Ya. , Podobivskyi Stepan S. , Kamyshnyi Alexandr M. , Saturska Аnna S. , Khavtur Vira О. , Marchuk Оlga М. , Zahrychuk Оksana М. , Furka Оlga B. , Cherniashova Valentyna М.
Published: October 2020

Introduction: Ixodine are an integral part of many biotopes, in particular rarefied deciduous and mixed forests, gardens, parks, squares, semi-steppe and steppe areas,
etc. Over the past decade, the role of ticks has increased in the transfer of pathogens of many diseases of animals and humans. In particular, these are tick borelliosis,
anaplasmosis, erlichiosis, babesiosis, and etc. An important element of the study of ticks is the study of their morphology, physiology, biology, medical and sanitary significance.
The aim: Investigation of morphological and physiological features of various life stages of ticks during the feeding period, studying the epidemiological state of acariana in
different seasons.
Materials and methods: The main materials and tools used to catch, keep and identify the ticks were tweezers, lenses, microscopic needles, white cloth for the «flag», alcohol
70%, test tubes. The study was carried out using optical and electronic system SEO-IMAGLAB. Investigation of epidemiological state was carried out using the polymerase chain
reaction (PCR) using amplifier method “ROTOR Gene -6000” in real time.
Results: As a result of the analysis of morphological parameters, certain regularities in the ratio of total body length to the width of the abdomen were found at different stages
of saturation. From the investigated acariana in 2017 to detect infectious pathogens, 46 females (39%), 56 nymphs (32%), 1 larvae (33.3%) were investigated. 2 undetected
acariana were carriers of 3 types of pathogens infectious diseases: Borrelia Burgdorferi senso lato (66 cases), Anaplasma phagocytophilum (30 cases) and Borrelia Miyamotoi (6
cases). According to the results of 2018, the number of carriers of the infectious agents was 158 (33.2%), which of them were females 58 (33.7%), males 2 (40%), nymphs 86
(32.5%), larvae 2 (10.5%).
Conclusions: Proceeding from the analysis of the infection frequency of Ixodes ricinus carriers of infectious diseases, it was found out the increase in the number of females
and nymphs of borrels carriers, from May to July with an average temperature increase of 18-230С to 25-270С and subsequently a decrease in the frequency of their infection
from August to October when the temperature drops to 20-150С.
PECULIAIRITIES OF THE FUNCTIONING CIRCADIAN
ORGANIZATION THE ION-REGULATING FUNCTION OF KIDNEY
UNDER THE CONDITION OF PINEAL GLAND HYPERFUNCTION OF
THE INFLUENCE NITROGEN MONOXIDE SYNTHESIS BLOCKADE
Authors: Semenenko Svitlana B. , Karatieieva Svitlana Y. , Bakun Oksana V. , Slobodian Ksenia V. , Yurkiv Oksana I.
Published: October 2020

The aim of our work was to investigate the peculiarities of the functioning circadian organization the ion-regulating function of pineal gland hyperfunction of the influence
nitrogen monoxide synthesis blockade.
Materials and methods: The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The control group included animals
(n=36) kept under conditions of usual light regimen (12.00L:12.00D) during 7 days. The experimental group included animals (n=36) injected with N-nitro-L-arginine (L-NNA)
in the dose of 20 mg/kg during 7 days under conditions of continuous absolute darkness (12.00D:12.00D). On the 8th day the animals were exposed to 5% water load with heated
to room temperature water supplied and the parameters of the kidney ion-regulating function under conditions of forced diuresis were investigated.
Results and conclusions: The obtained results of the performed blockade nitrogen monoxide (NO) synthesis in conditions of hyperfunction of the brain epiphysis allow to
conclude that the daily mean of the rate of excretion of sodium ions decreases in comparison with the animals that were kept under pineal gland (PG) hyperfunction of the
filtration fraction and reabsorption of sodium ions are reduced compared to the control animals and rats which were kept under conditions of PG hyperfunction and accompanied
by stable indicators of the concentration the specified cation in the blood plasma during the observation period. The action of the blockade NO synthesis in conditions of PG
hyperfunction leads to a decrease in the distal transport bridge of sodium ions with a maximum in the day and night intervals of the day the position of the acro- and batiphase
of the rhythm changes as compared with the control animals.
QUANTITATIVE ASSESSMENTS OF THE QUALITY OF MEDICAL CARE FOR PATIENTS IN CONDITIONS OF PRIVATE-STATE PARTNERSHIP
Authors: Hanynets Petro P. , Sinіenko Natalia A. , Mintser Ozar P.
Published: October 2020

Introduction: The article discusses the problems of joint activities of public and private sectors to ensure the proper quality of medical services and jointly overcome financial and production risks. It is emphasized that if the financial and administrative issues of such interaction have been studied to a certain extent, then a quantitative assessment of the quality of medical care provided in a public-private partnership has so far raised questions The aim: Identify ways to use industrial quality criteria for providing medical care to patients in public-private partnership conditions. Materials and methods: The results of rehabilitation of 300 patients with gastrointestinal pathology who underwent rehabilitation in the resort “Kvitka Poloniny” of the TOV “Suzirya” were studied. 160 patients underwent rehabilitation in the private part of the resort, 140 – in the state. Results and conclusions: The theoretical approaches to the use of scientific and technological tools for the implementation of public-private partnership in medical institutions, in particular in a rehabilitation center, are discussed. They are based on instrumental approaches to assessing the quality of medical care. The use of Pareto assessment techniques and the Taguchi loss function allows us to quantitatively characterize the improvement in the quality of care provided with the help of public-private partnership.
VACCINATION COVERAGE RATES AND THE INCIDENCE
OF VACCINE PREVENTABLE DISEASES AMONG CHILDREN
IN SUMY REGION OF UKRAINE
Authors: Smiianov Vladyslav A. , Zaitseva Halyna S. , Kurganskaya Victorya A. , Dyachenko Anatoly G. , Zbarazhskyi Volodymyr P. , Smiianov Yevhen V. , Pilipec Olha A.
Published: October 2020

Introduction: Routine immunization contributes immensely to decline the incidence of vaccine preventable diseases among children. Statistical data shown the sharply
decrease the vaccination coverage rates in Sumy region of Ukraine.
The aim: Assess routine immunization uptake and its effect on the incidence of vaccine preventable diseases among children in Sumy region of Ukraine.
Review: During some years, only 50-60 % of Sumy region children had received all recommended vaccines, which is far below World Health Organization target of 80 %. This
has led to an increase of morbidity associated with some infectious diseases. Outbreaks of measles were registered in 2006 and 2012, when were ill 9346 and 7931 children
respectively. Massive measles outbreak ongoing nowadays. Total number infected have already exceeded 35,000 cases.
Conclusions: RI uptake in Ukraine is still below World Health Organization target. The main reason for the ongoing measles outbreak was low vaccination coverage for routine
immunization antigens as a result of which collective immunity decreased to a critical level. Strict monitoring of the implementation of the immunization schedule by medical
institutions at all levels are recommended to improve vaccination status of Ukrainian children.
HYGIENIC ASSESSMENT OF THE EFFECTS OF PESTICIDES
APPLICATION ON CHILDREN POPULATION MORBIDITY
WITH THYROID GLAND DISEASES
Authors: Antonenko Anna M. , Vavrinevych Olena P. , Korshun Maria M. , Omelchuk Sergii T.
Published: October 2020

Introduction: It is proved that some groups of fungicides and herbicides are capable of affecting the thyroid gland, provoking its growth, leading to a compensatory change
in the activity of the hormones synthesis. Therefore, the presence of their residual amounts in plant may affect the level of thyroid gland pathology.
The aim of the work was to analyze the influence of pesticide application on the Ukrainian child population morbidity with thyroid diseases in the period from 2001 to 2014.
Materials and methods: The methods of empirical and theoretical research of scientific information, namely analysis, synthesis, induction, deduction and systematization,
epidemiological, cartographic and statistical methods were used.
Review: The maximum level of thyroid pathology was found in the northern, western and northwestern regions, where the diffuse goiter dominates in the morbidity and
prevalence of thyroid diseases; minimal – in the southern, eastern and south-eastern regions. It was established that the highest volumes of application of chemical plant
protection products in the period 2001-2013 took place in the southern and central regions of Ukraine, namely in Poltava, Vinnitsa, Kharkiv, Dnipropetrovsk, Khmelnytsky regions.
Sufficiently high levels of pesticide application were in the Kyiv, Kherson regions, Zaporizhia, Kirovograd and Cherkasy regions.
Conclusions: The probability of the active chemical plant protection products application effect on the level of thyroid cancer, various types of goiter, hypothyroidism, thyrotoxicosis
and thyroiditis in the central and southern regions was determined. These are regions with well-developed agricultural production.
POSTNATAL PERIOD PSYCHOLOGICAL ASPECTS
Authors: Herasymenko Larysa O.
Published: October 2020

The result of labour is not only the birth of a child but also the formation of a mother, woman who has got to know motherhood. Moreover there is a radical change in the social
status of the couple as a whole. It turns into a mother and father. The consequence of this is a change in attitude towards yourself and others, that is, the transformation of the
personality. This explains why during pregnancy and delivery the risk of family problems worsening rises sharply and somatic and neuropsychic disorders emerge. The aim of
the work is to describe and systematically outline the main psychological and psychiatric aspects of the postnatal period in the life of a woman and a child. Changes occur in
the life of a woman, and the possible to diagnose the manifestations of disharmonious development in a timely manner, to prevent and help to solve them constructively. The
information is presented taking into account both historical aspects and the state of the issue in modern society.
ENSURING THE CONTINUITY OF MEDICAL CARE
AT THE STAGE OF PATIENTS REHABILITATION
Authors: Sarkanich Оleksandr , Shevtsova Оlena , Mintser Ozar
Published: October 2020

The problems of ensuring continuity of medical care are considered. Information and cybernetic issues of continuity, in particular information standards, resource management
systems of a medical institution, are analyzed. It emphasizes the need to develop standards for the continuity of care. It is concluded that long-term continuity of medical measures
in rehabilitation is one of the main components of the effectiveness of medical care. Further qualitative research is needed, including some types of rehabilitation services (e. g.
specialized medical care). At the same time the most important factors for ensuring continuity at the current stage of medicine development are the use of ontologies, representing
the most general conceptual concepts of the modeled field of medicine, completely abstracted from specific models of knowledge representation and practical implementation.
It is also shown that the specification of the patient management model in the rehabilitation period of treatment is provided by a wide application of telemedicine consultations.
The index of continuity of medical aid is also proposed. It represents a simple additive function that reflects the change in the probability of an unfavorable outcome.
THE RIGHTS OF SURGEONS WHILE WORKING
WITH HIV-INFECTED PATIENTS IN UKRAINE
Authors: Komziuk Anatolii T. , Velichko Dmytro M. , Goshovskyі Volodymyr S. , Goshovska Valentyna A. , Klymenko Olena V.
Published: October 2020

Introduction: Surgeons that are working with HIV-infected patients in Ukraine are in a vulnerable state due to the lack of special regulation of this issue in labor, medical law
and labor contract, as well as the spread of HIV among the population of the country.
The aim of this article is to determine and uncover the content of the rights of surgeons while working with HIV-infected patients in Ukraine.
Materials and Methods: The research materials of the rights of the surgeons that are working with HIV-infected patients consist of national legislation, official explanations
of the Social Insurance Fund of Ukraine, statistics on HIV infection. The research methods that have been used are cross-sectoral, complex statistical, analysis and synthesis. In
order to obtain the results of the research the norms of medical, labor and civil law have been analyzed.
Review: The authors of the article have emphasized and described the rights of surgeons that are working with HIV-infected patients.
Conclusions: It has been proved that the current system of surgeons’ rights needs to be improved. It has been offered: to establish, at the legislative level, the responsibility of
the patient with HIV infection to warn a medical employee about his infection in case of surgery or other medical manipulation that leads to contact with blood or other biological
materials; to revise and significantly increase the payment of obligatory insurance of surgeons, if they are infected by a patient with HIV infection.
HIV/AIDS IN THE GUISE OF A DEMYELINATING DISEASE
Authors: Dyachenko Pavel A.
Published: October 2020

Introduction: A significant part of patients with HIV / AIDS develops damage to the nervous system. There are also cases where opportunistic infections of the nervous system,
especially herpes viral origin, can hide the underlying disease, making it difficult diagnosis.
The aim: To show the possibility of HIV infection mimicry a neurological pathology.
Clinical case: A 41-years-old female presented to The Cеntег of Infectious disorders of the Nervous System (Kyiv, Ukraine) in August, 2018 after developing acute fever following
by a left side hemiparesis, violation of coordination. Tuberculosis and HIV denied. Her physical examination showed tremor in her hands during a Barre-probe. She performed
the coordination tests with intent, staggering in the Romberg pose. A small brain lesion was revealed at MRI. Antibodies to HSV1/2, CMV, Tox. gondii were found in the CSF
and blood. Blood PCR was reported to be positive for EBV DNA, and HCV RNA. A rapid HIV test was negative. A repeated blood test performed 10 days after admission showed
low level of CD4+ T cells (36 cells /1 μl), and HIV RNA (850,104 cp / ml). HIV antibodies were also revealed. As a result, patient was transferred to a specialized department for
further treatment.
Conclusion: Considering high clinical polymorphism of HIV/AIDS, physicians of all specialties should be alert for the possible neurologic manifestations of this disease to timely
examine patients.
A COUGH IN A PATIENT WITH CHOLANGITIS IN THE COURSE
OF CAROLI’S DISEASE. CASE REPORT
Authors: Kaszyńska Aleksandra , Zielonka Tadeusz M. , Życińska Katarzyna
Published: October 2020

Cough may be a manifestation of pulmonary and extra-pulmonary diseases. However, rarely liver disease is suspected as a cause of acute cough. A case of a 34-year-old patient
with diagnosed Caroli’s disease has been described, in which cough with fever was the main manifestation of cholangitis in the course of complications of the underlying
disease. Caroli’s disease is a congenital pathology of intrahepatic bile ducts, causing their cysts to widen. It usually has an asymptomatic course, however it promotes infectious
complications such as liver abscesses and recurrent cholangitis. The patient was admitted to the ward because of high fever and cough, without any symptoms from the digestive
system. On the basis of laboratory, microbiological and visual examinations, various causes of cough were excluded and a diagnosis of cholangitis was made. After appropriate
antibiotic therapy, a rapid improvement in the clinical condition and resolution of symptoms was achieved.
FEATURES OF ANGIOARCHITECTURE OF THE ALBINO RATS STOMACH AND SMALL INTESTINE
Authors: Hryn Volodymyr H. , Kostylenko Yuriy P. , Bilash Valentyna P. , Tarasenko Yana A.
Published: October 2020

Introduction: The stomach and small intestine are important organs of the digestive system and, to date, they are the subject of research by morphologists, endocrinologists, immunologists, gastroenterologists, and other researchers. The aim: The paper is aimed at the study and systematization of the features of angioarchitecture of the albino rats stomach and small intestine. Materials and methods: The study based on the injection of the blood vasculature of abdominal organs of 20 albino male rats with 5% gelatin solution, colored with filtered black ink, was performed. The specimens were subject to photographing from different aspect angles in their original state, and then, after dehydration in alcohols with the transition to pure acetone, they were embedded in the epoxy. Photographing of the obtained specimens was made by a digital camera, as well as a binocular magnifier MBS-9, equipped with a digital photoattachment Sigeta DCM-900 9.0MP. Results and conclusions: The results of injecting of blood vasculature of albino rats’ gastrointestinal tract with ink mass clearly demonstrate the specific difference in the intraorganic angioarchitecture of its different regions, which depends entirely on their functional purpose in the digestive process. In the stomach, the highest concentration of blood microvessels is in its glandular part, which is explained by the increased nutrient needs of the secretory process of the gastric glands, while the mucous membrane of its fundus (pre-stomach) contains a scattered network of exchange microvessels that only promote the process of regeneration of the stratified squamous (partially keratinized) covering epithelium. In the small intestine, the typical principle of the organization of the microvasculature of its mucous membrane is somewhat modified in the duodenum, which is associated with the presence of mucous (Brunner’s) glands in it, as well as in those sites (starting from the duodenum) where the group lymph nodes (Peyer’s patches) are localized.
MORPHOMETRIC DESCRIPTION OF THE EXCHANGE SEGMENT
OF MICROVASCULATURE OF RATS’ SALIVARY GLANDS IN
NORMAL CONDITIONS AND CHRONIC ETHANOL INTOXICATION
Authors: Shevchenko Kostyantyn V. , Yeroshenko Galyna A. , Yakushko Оlena S. , Kazakova Kateryna S. , Kramarenko Denys R.
Published: October 2020

Introduction: The state of the segments of the microvasculature, especially exchange one, has a significant effect on the organs’ functions. The results of it’s research can be
objectified by morphometric method.
The aim: to determine the dynamics of changes in metric indices of the exchange segment of microvasculature of rats’ submandibular glands in normal conditions and in
chronic ethanol intoxication.
Materials and methods: 45 albino rats were involved into study. Intact group (n=5) animals were administered with NaCl isotonic solution 4 times a day directly into the
stomach. Experimental group (n=40) animals were administered with 40° ethanol 4 times a day directly into the stomach. Animals were sacrificed on 5, 9, 12 and 30 days by
overdose of thiopental anesthesia. Lobules of submandibular glands were embedded into epon-812 according to standard procedure.
Results: On day 5 of the experiment the outer diameter of the capillary wall significantly reduced (4,91±0,02 μm), that is 19,5 % less than the values in controls (р<0,05).
On day 9 of the experiment it was 15,2 % lower than the value of control group (р>0,05). On day 30 of the experiment the outer capillary diameter was 8 % lower compared
to controls (р<0,05).
Conclusions: The early observation showed vasodilatation, confirmed by the constriction of the outer diameter and lumen diameter, accompanied by the thickening of the
vascular wall under the influence of chronic ethanol intoxication. The indices did not come to normal values by the 30-th day of the experiment.
CERVICAL CANCER – CAUSES AND PREVENTION OF HPV
INFECTIONS IN THE OPINIONS OF YOUNG POLISH WOMEN:
A CROSS-SECTIONAL SURVEY
Authors: Kotowski Artur , Kotowska Maja , Warzyszyńska Aleksandra , Szymusik Iwona , Kosińska-Kaczyńska Katarzyna , Fal Andrzej M.
Published: October 2020

Introduction: Cervical cancer is an important issue of gynecologic oncology. The awareness of this disease, the attitude towards HPV vaccination and cytological screening play
an important role in decreasing morbidity and mortality due to cervical cancer.
The aim: To assess the various aspects of knowledge regarding cervical cancer, risk factors for this disease, the role of HPV infection and the attitude to primary (vaccination)
and secondary (cytological screening) prevention among young women.
Materials and methods: The study was performed using CAWI method based on original questionnaire in electronic form. Online completing of the survey was voluntary
and anonymous.
Results: The study was conducted in a group of 2058 women aged 19-33. In total 98.4% of respondents came across the term “cervical cancer”, 84.1% knew that cervical cancer
could be prevented and the following were identified as the main risk factors: cervical cancer in closest relatives (85.3%) and HPV infection (81.9%). Although according to 82.0%
of women HPV infection can be prevented by vaccination, only 18.4% of respondents were vaccinated. The main reason for non-vaccination was lack of knowledge about the
availability of the vaccine (41.2%) and high price (32.0%). Of the unvaccinated people, 63.5% declare their will to be vaccinated in the future. Concerning secondary prevention,
98.6% of the respondents admitted that they knew the term “cytological examination”, 89.0% indicated that this examination detected the presence of pre-cancerous lesions,
and according to 58.4% of respondents, this test should be performed after sexual initiation. Despite the fact that 80.5% of respondents confirmed the fact of beginning sexual
activity (44.4% of them had more than 1 partner), 17.1% of the respondents admitted that they didn’t go to gynecologist yet. Approximately 84% of respondents believe that
the amount of information on cervical cancer prophylaxis and HPV infections currently providing is insufficient.
Conclusions: The basic terms regarding primary (vaccination) and secondary (prophylactic tests) prevention of cervical cancer have been widely known. However, the knowledge
about specific risk factors, sexual behaviors contributing to HPV infection and, consequently, the ability to self-identify as belonging to higher risk group is insufficient. It is
justified to conduct educational activities regarding the assessment of risks related to cervical cancer addressed to young women. Together with education, HPV vaccination
and secondary prevention programs require financial support.
CHOICE OF SURGICAL TACTICS AT THE STAGE OF PREOPERATIVE
PREPARATION OF PATIENTS WITH BILIARY SEPSIS
Authors: Vovchuk Igor M. , Katsal Vitalij A. , Khromykh Kateryna V. , Balabueva Victoria V. , Hudz Maxim A.
Published: October 2020

Introduction: There is a problem of choosing the optimal method for eliminating choledocholithiasis in accordance with one The lack of satisfactory results from the use of
existing methods of surgical correction explains the constant interest of specialists to this problem, requires the improvement of the commonly accepted and the search for new
approaches to the treatment of this concomitant disease.
The aim: To substantiate the use of individual assessment at the stage of preoperative preparation for the purposeful differential tactic of surgical treatment of the biliary sepsis.
Materials and methods: The basis of our research was the results of the analysis of treatment of 112 patients with biliary sepsis who were on treatment from 2010 to 2017 in
the surgical clinic № 2. An assessment of systemic inflammation performed according to the recommended criteria of the Chicago Interventional Conference on Intensive Care
(USA, 1992). The systemic inflammatory response syndrome (SIRS) was determined in the presence of 2 or more symptoms: 1) t body> 38 ° C or <36 ° C, 2) heart rate> 90 / min;
3) breathing frequency> 20 / min; 4) white blood cell count> 12 × 109 / l or <4 × 109 / l; or> 10% immature forms (SOFA score 4, 27 ± 0.6 points).
Results: Based on the received pre-operative score, we proposed to optimize the differentiated selection of individualized surgical tactics, taking into account the available
baseline conditions, to radically eliminate the cause of biliary sepsis and evaluate the measures of initial conservative therapy. In the course of work, anamnestic unit, clinical
unit, laboratory-instrumental block used. The initial severity of the condition of each particular patient is calculate according to the received sum of points for each information
block, which allows at the stage of preoperative preparation to standardize all patients in accordance with their score.
Conclusion: Thus, the ball assessment of the severity of the condition of patients allows us to determine not only the optimal tactics, the size and type of surgical correction,
but also to determine the effectiveness of the selected composition of preoperative preparation and postoperative treatment, carrying out its dynamic assessment.
ASSOCIATION OF NONALCOHOLIC FATTY LIVER DISEASE
WITH SMALL INTESTINE BACTERIAL OVERGROWTH IN OBESE
CHILDREN
Authors: Stepanov Yuriy M. , Zavhorodnia Natalia Yu. , Yagmur Victoria B. , Lukianenko Olga Yu. , Zygalo Elvira V.
Published: October 2020

Introduction: In recent years, NAFLD is considered as the key of the so-called metabolic inflammation, in which the intestinal microbiota plays an important role.
The aim: To determine the effect of small intestine bacterial overgrowth on the liver structural and functional parameters in children with obesity and overweight.
Materials and methods: The object of the study was 89 children with obesity/overweight. Depending on the presence of SIBO based on the results of the hydrogen breath
test with glucose, the patients were divided into 2 groups: first (I) consisted of 31 children with SIBO, the second (II) included 58 children without SIBO. All the patients under
study performed a general blood analysis and a biochemical blood test, immuno-enzyme test method with insulin level determination HOMA index calculation. For diagnostics
of the liver steatosis, transient elastography with the CAP (controlled attenuation parameter) function was carried out using FibroScan® 502 touch (Echosens, Paris, France).
Results: According to fibroscan data, the presence of SIBO in obese children can lead to raise of CAP level; liver steatosis was diagnosed in 22 patients (70.9%) of the 1st group
and 24 patients (41.4%) of the 2 group (p<0,05). We found significant differences in the the ratio of neutrophils and lymphocytes (NLR) (p <0.05). The average glucose level
and HOMA index were significantly higher in SIBO group (p<0,05). The analysis of risk factors of SIBO showed that metabolic syndrome and NAFLD as the risk factors for SIBO
development (p<0,05).
Conclusions: SIBO has an effect on the structural and functional characteristics of the liver resulting in higher insulin and glucose level, higher NLR level and greater prevalence
of NAFLD.
CLINICAL CHARACTERISTICS OF CARDIAC ARRHYTHMIAS
IN PREGNANT WOMEN
Authors: Afanasiuk Oksana I. , Shmaliy Valentyn I. , Shushkovska Yuliia Yu.
Published: October 2020

Introduction: Cardiac arrhythmia often occurs in the gestational period of pregnant women, contributing to the development of complications of pregnancy, childbirth and
perinatal pathology, which requires a more thorough examination of pregnant women and antiarrhythmic treatment, which in turn increases the risk of complications pregnancy
and childbirth. Many types of arrhythmias occur in women without structural damage to the cardiovascular system.
The aim is to study the occurrence of cardiac rhythm disturbances in healthy pregnant women, depending on the gestational age, the number of previous pregnancies, infectious
diseases during pregnancy, and arrhythmia analysis, which required antiarrhythmic treatment. Materials and methods: Retrospectively 60 individual cards of pregnant women
were studied. An ECG monitoring was performed to identify the arrhythmia.
Results: Among the arrhythmia were: supraventricular and ventricular extrasystoles, unstable paroxysmal tachycardia. All cases of arrhythmia were without lengthening QT
interval. Sinus tachycardia was significantly more common in combination with anemia. Heart rhythm disorders are associated with emotional excitement.
Conclusions: Most violations of the heart rate occurred in the second trimester of pregnancy. With concomitant anemia, sinus tachycardia is significantly more common, and sinus
bradycardia is associated with an enlarged uterus in compression of the inferior vena cava. With the increase in the number of pregnancies, the risk of heart rhythm disturbances
increases. However, the past infectious diseases of the bronchopulmonary system during pregnancy did not significantly affect the occurrence of rhythm disturbances. The
appointment of antiarrhythmic drugs was observed in all pregnant women whose cards were included in the study.
ALLERGEN COMPONENT TESTING – A NEW ERA IN DIAGNOSTICS
OF PATIENTS WITH POLLEN ALLERGY
Authors: Zubchenko Svitlana , Sharikadze Olena , Maruniak Stepan
Published: October 2020

Introduction: Pollen allergy, also called hay fever or pollinosis, is referred to the most widespread allergic diseases. According to different sources, from 5 to 34% of the population
in developed countries are likely to suffer from this condition. Moreover, the majority of patients are young people of working age
The aim: To demonstrate a practical decision of the choice of effective treatment tactics based on component testing in patients with pollen allergy.
Materials and methods: 126 рatients with allergic rhinitis / conjunctivitis were randomly selected according to their primary visit during the first week in August of the
current year. Among them, 53 (42.0%) female and 73 (58.0%) male, aged 22-47 years. General laboratory and instrumental investigations, skin prick test with allergen extracts
(Diater, Spain), measurement of total serum and specific IgE by immunoenzymatic assay method using test system “Euroimmun” were performed. Immunofluorescent method
ImmunoCap (Thermo Scientific, Uppsala, Swiss) was used to detect specific components of allergens. The material of investigation was blood serum.
Results: According to the results of skin prick-test, 50% of patients could receive allergen immunotherapy with two different extracts of allergens “Mixture of Weeds” and “Mixture
of Grass”. On molecular investigations, it was detected that this combination was not suitable for any patient (20% of individuals had genuine sensitization to allergens of grass
pollen, including a marker of cross-reactive molecules, 30% of individuals were sensitized with genuine allergens of Artemisia and/or ambrosia).
Conclusions: Based on skin prick-test and molecular diagnostics, the doctor makes a completely different decision on the choice of extracts for allergen immunotherapy
conduction. Component determination of a sensitized profile and high sensitivity of this method enables to reveal a genuine protein, which is the primary cause of allergy
occurrence and administer etiotropic allergen-specific immunotherapy with the allergen, to which sensitization was detected.
DETERMINATION OF POOR OUTCOME PROGNOSIS IN PATIENT WITH ACUTE LEUCEMIA WHICH WAS COMPLICATED BY PNEUMONIA
Authors: Borisova Inna S. , Stepansky Dmitry O.
Published: October 2020

Introduction: At the present stage, the medicine development is based on the principles of evidence-based medicine, which requires using of statistical methods and forecasting. Using statistical analysis and possibilities and mathematical forecasting emphasizes the probability of obtained data in scientific medical research. Identifying the factors that determine the survival of patients with acute leukemia and pneumonia causes the conduct of this study. The aim: To create a mathematical model of poor outcome prognosis in patients with acute leukemia, which was complicated by pneumonia, to determine the treatment place and timely optimize the treatment. Materials and methods: An electronic database of formalized disease history of 360 patients with acute leukemia and pneumonia was created. The data base contained data of objective survey and additional research methods. In our study we used non-parametric dispersion analysis of Kraskele-Wallis, correlation analysis with the calculation of Spierman’s rank correlation coefficients, simple and multiple logistic regression analysis with the calculation of the odds ratio; ROC analysis. The significance level p <0,05 was considered statistically significant. Results: It was determined that with the onset of the lethal outcome of patients with pneumonia, developed on the background of acute leukemia, the indicators of leukocytes, lymphocytes, neutrophils, platelets, erythrocytes, hemoglobin and immunity indexes (B(CD19+), T(CD4+), CD4+/CD8+, IgG). According to the results of our study, a mathematical model of prediction poor outcome in patients with acute leukemia, which was complicated by pneumonia, was created: PPO=exp(-10,317+0,410* В(CD19+) -2,149* IgG)/ [1+exp(-10,317+0,410* В(CD19+) -2,149* IgG)]. Conclusion: Using in clinical practice the proposed mathematical model of prediction poor outcome in patients with acute leukemia, which was complicated by pneumonia, will allow determining the treatment place and timely optimizing the treatment program.
CONDITION OF FAGOCYTOSIS OF EXPERIMENTAL ANIMALS
WITH PERIODONTITIS DUE TO MODIFIED REACTIVITY
Authors: Avdeev Oleksandr V. , Drevnitska Roksana O. , Boykiv Alina B. , Vydoinyk Oksana Ya.
Published: October 2020

Introduction: Taking into account the patho-immune mechanisms of formation of inflammatory process in periodontium, there is a necessity for in-depth study of the
pathogenesis of periodontal diseases from the position of changes in the reactivity of the organism.
The aim: Carrying out a comparative estimation of phagocytic activity of leukocytes of animals with inflammation in periodontium with altered reactivity.
Materials and methods: Experiments were performed on 30 white rats: Group I - 10 white rats with hypoergic reaction; Group ІІ - 10 white rats with hyperergic reaction;
Group III - 10 white rats with normergic reaction - control group. Slaughter and blood sampling under thiopental anesthesia was performed 7 days after the beginning of the
experiment. The percentage of phagocytic leukocytes - phagocytic index, phagocytic number were determined and the index of phagocytic activity was calculated.
Results: The phagocytic index (Fi,%) decreased by 2,09 times (p <0,05) at hypoergic, it increased by 1,37 times (p <0,05) at hyperergic; the index of phagocytic activity (IFA)
decreased by 1.96 times at hypoergic (p <0.05); growth was 1.94 times (p <0.05) in the hyperergic group of animals. In both experimental groups, the phagocyte number (Fu)
increased by 6.25% and 41.7%, with hypoergic and hyperergic, respectively.
Conclusions: Different directions of changes of the phagocytic activity were observed: increase of these parameters at hyperergic and decrease at hypoergic. An increase in
phagocyte number was likely to indicate some autonomy of the process of phagocytosis and independence from the reactivity of the organism.
ASSESSMENT OF THE EFFECTIVENESS OF THE GASTROPATHY
RISK REDUCTION PROGRAM IN PATIENTS WITH ARTERIAL
HYPERTENSION
Authors: Akhmedova Anastasiia A. , Ocheredko Oleksandr M. , Klimenyk Volodymyr P.
Published: October 2020

Introduction: For primary health care patients with concomitant morbidity are usual phenomena. Combination of gastropathy with arterial hypertension is increasingly being studied.
However, the assessing of the medical and economic effectiveness of treatment of patients with concomitant morbidity still methodologically challenging. The issue aggravated by
different cushion programs aimed to alleviate financial burden to indigent population. These cover non-expensive drugs with probable hazard to concomitant morbidity.
The aim: to evaluate the effectiveness of the gastropathy risk reduction program in patients with arterial hypertension (AH).
Materials and methods: data on 150 patients with AH collected by panel design with dynamic cohort traced up to 17 years. We have elaborated a program for the prevention
of gastropathy in patients taking antihypertensive therapy. Program is based on regulations of the Ministry of Health of Ukraine, adapted clinical guidelines, and other official
sources of information, since holistic prevention of gastropathy is not depicted in any source. Two main cohorts were distinguished: those in prevention program (PP) and patients
with usual treatment. 6 built in cohorts (Group№0-№5) helped to diversify PP across groups of different severity. Event of interest was incidence or aggravation of gastropathy
(gastroduodenitis mainly). We used Poisson model to study average treatment effect of PP on annual number of aggravations.
Results: The main effect of program participation is significant in a model of fixed effects (β = -0.269; p = 0.0156), and even more supportive in the mixed model (β = -0.282;
p = 0.0097). Other components with a variable “PP participation”, namely participation in the program given the group, participation in the program given GP duration,
participation in the program given compliance, appeared to be nonsignificant, that suggest absence of substantial selection bias due to non-randomness of allocation. The
greatest risk reduction due to program participation was in patients of Group0, that is, in patients with hypertension who do not receive antihypertensive therapy. In groups
№1-№5 with more aggressive hypertension treatment the effects of program participation are obvious but less pronounced.
Conclusions: The elaborated program differentiates patients by groups and furthermore allows one to consider each patient characteristics, taking into account income, age,
gender, progression of the disease, comorbidity, drugs the patient takes. The established program based on cooperation of patient, general practitioner, and gastroenterologist.
We reduced selection bias due to possible randomness blemishes in allocation to the PP by control function method. The main effect of program participation is significant in a
model of fixed effects (β = -0.269; p = 0.0156), and even more supportive in the mixed model (β = -0.282; p = 0.0097).
BIOMARKERS OF INTRAUTERINE GROWTH RESTRICTION
Authors: Gulczyńska Ewa , Peterson Ewa , Radzik Tomasz , Żylińska Ludmiła
Published: October 2020

Intrauterine growth restriction (IUGR) is a serious clinical problem affecting about 10% of all pregnancies, and even up to 15% of all monochorionic twin pregnancies. This disorder is accompanied by strongly increased perinatal mortality. IUGR has multiple causes including maternal, fetal, placental, and environmental factors. Importantly, IUGR is associated with a number of negative effects exerted just after the birth, as well as during the later years of life. Despite multiple clinical trials conducted for many years, there is no reliable algorithm to diagnose the disease at an early stage, and lack of efficient therapy increases the risk of abnormal fetus development. In this short review, we present recent progress on potential IUGR biomarkers that could be determined during pregnancy and in the umbilical blood after delivery to provide more accurate diagnosis, prophylaxis and efficient treatment.
INTEGRATED ESTIMATION OF THE DEMOGRAPHIC SITUATION
IN UKRAINE – FORECAST FOR THE FUTURE
Authors: Chornenka Zhanetta A. , Domanchuk Tetiana I.
Published: October 2020

Introduction: The demographic situation in the country is largely due to the state of the economy and reflects the medical and social conditions of the population, which in
turn testify to the state of the economy, the health care system, education, culture, and other factors.
The aim: Analysis and comparison of the demographic situation in Ukraine with the EU countries, forecast for the future.
Materials and methods: The statistical materials of the Center for Medical Statistics of the Ministry of Health of Ukraine 2012-2016 were processed. A medical-statistical
analysis of the system’s performance indicators for the five components carried out; an assessment of the performance of the health system according to the WHO approach
with certain modifications used.
Review: Having analyzed the statistics of the last years in Ukraine, the birth rate in 2017 decreased as compared to 2016, in January-April 2017 there was a natural decrease
in the population, while migration processes in Ukraine exceeded immigration beyond its borders. In connection with the antiterrorist operation in the east of the country and
the beginning of active hostilities in the region, the population was significantly reduced to 43 million people. Life expectancy has also changed, and today the average life
expectancy in Ukraine is 71 years (66 years are men, 75 are women).
Conclusions: It is necessary to concentrate efforts on solving current problems - economic birth control, adequate social protection of families with children and the elderly,
promoting a healthy lifestyle, ensuring the availability of quality medical care and education, which in turn will ensure an increase in the duration of a full active life.
LICHEN PLANUS AND COMORBID CONDITIONS (A REVIEW OF LITERATURE)
Authors: Bilovol Alla M. , Tkachenko Svitlana H. , Havryliuk Oleksandra А. , Berehova Alla А. , Tatuzian Yevheniia H. , Kolhanova Nataliia L. , Stetsenko Svitlana O.
Published: October 2020

Introduction: The studying of the comorbidity of skin diseases is a priority scientific direction in modern dermatology. Comorbid conditions aggravate the course of the underlying disease, reduce the effectiveness of diagnosis and treatment can lead to chronization of the process, disability of patients. Understanding of the commonality of pathogenesis and the mutually complicating nature of comorbidity makes a possible to prescribe individual rational treatment. The aim of the study was search and analysis of the data of review, experimental and clinical scientific and medical publications on the issues of the comorbidity of LP. Materials and methods: an analysis of the studying of the scientific and medical literature was shown. Searching was carried out through the PubMed/MEDLINE portal from the databases of the National Center Biotechnology Information, U. S. National Library of Medicine, National Institute for Health and Clinical Excellence, as well as the portals «Scientific Electronic Library eLIBRARY.RU», «Russian Science Citation Index (RSCI)» and «Index Copernicus». Conclusions: The main global trends of comorbidity of LP are determined. The results of these studies can form the basis for updating of clinical guidelines for the management of patients with LP at the international and local levels.
PROBLEMS OF TRANSPLANTATION OF HUMAN ORGANS AND OTHER ANATOMICAL MATERIALS AND DIRECTIONS OF THEIR SOLUTION IN UKRAINE
Authors: Kraіnуk Нrуhorіі S. , Pороva Svitlana M. , Vakulovych Ella V.
Published: October 2020

Introduction: The focus of the work is the importance of transplantation of human organs and other anatomical materials as the method of treating and a way of saving people’s lives and it also attaches particular importance to solving issues of transplantations in Ukraine. The aim: To find out the problems of human organ transplantation and other anatomical materials and determine the directions of their solutions in Ukraine. Materials and methods: The assessment and analysis of domestic and foreign experience has been developed. In addition, data collected from Ukrainian and international organizations and the results of scientific research by scientists are used in the work. Review and conclusions: Investigating the legislation of Ukraine in the part of transplantation of human organs and other anatomical materials, conclusions were made on the necessity of its improvement, in particular, Article 16 of the Law of Ukraine «On the application of transplantation of anatomical materials to a person» dated by May 17, 2018, is proposed to be worded as follows: «Any adult may give written consent or disagreement to become a donor of anatomical materials in case of his death. In the absence of such a statement of disagreement with the transplantation of his organs or other anatomical materials, consent of relatives or others is not required. In this case, the deceased person is deemed to have given consent to the transplantation of his organs or other anatomical materials». It is proposed to make changes and significant additions to Art. 17 of the Law of Ukraine «On the application of transplantation of anatomical materials to a person» of May 17, 2018 regarding the creation of the Unified State Register of persons in need of transplantation, as well as to consolidate the procedure for its administration. In the context of urgent transformations, the necessity to significantly increase state funding for the provision of medical services, raise the awareness and informality of citizens about transplantation, as well as to change their misconceptions about this issue are sometimes put forward.