bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevention of Inflammation Initiation on Acetic Acid-Induced Ulcerative Colitis in Rats by Malva nicaeensis All.
Authors: Küpeli Akkol Esra , Türkcanoğlu Gizem , Taştan Hakkı , Sobarzo-Sánchez Eduardo
Published: July 2023

Background: Aerial parts of Malva nicaeensis All. are preferred in the prevention and treatment of intestinal infections and hemorrhoids in Turkish traditional medicine. This study is planned to evaluate the pharmacological activity of M. nicaeensis extracts on rats with acetic acid-induced colitis. Methods: The plant material was subsequently extracted with n-hexane, ethanol, and water, respectively. All of these extracts were tested for efficacy in the acetic acid-induced rat colitis model. The aqueous and polysaccharide extracts regulated cytokine levels and antioxidant parameters. Furthermore, the aqueous extract in particular regulated myeloperoxidase and caspase-3 levels in this rat model. In addition, the polysaccharide-rich fraction was separated from the aqueous extract. Results: The polysaccharide-rich fraction and aqueous extract regulated cytokine levels and antioxidant parameters. The aqueous extract also positively affected myeloperoxidase and caspase-3 levels. The phytochemical studies revealed that the aqueous extract had the highest phenolic content. In addition, the polysaccharide fraction was found to contain total sugars, sulfated groups, uronic acids, and total proteins in 78.4%, 0.9%, 1.5%, and 14.7%, respectively, and was rich in monosaccharide-type compounds, especially galactose (36.4%). Conclusions: M. nicaeensis was discovered to be a drug lead in the future treatment of irritable bowel diseases or as a complementary therapeutic agent that aided conventional treatments.
Mad Honey Intoxication: A Rare Case Report
Authors: Khakural Raunak , Shrestha Shailesh , Pandey Kundan Raj , Gurung Sanyukta
Published: July 2023

Honey containing grayanotoxin is called mad honey which is found in Turkey, Japan, Brazil, Europe, North America and Nepal. Patients present with clinical manifestations like bradycardia, hypotension and syncope. In this case report we present a 27 years male who presented with bradycardia and first-degree heart block after consumption of only 10 grams of mad honey.
THIS LAND OF OURS – PROTECTING OWNERSHIP, INTEREST AND DEALINGS IN LAND
Authors: Zuraidah Ali  , Nor Asiah Mohamad  , Sharifah Zubaidah Syed Abdul Kader
Published: July 2023

This article highlights the contribution of Almarhum Tan Sri Harun M. Hashim in laws relating to land and trusts. The research methodology employed for this study is legal doctrinal, through analysing Tan Sri’s judicial decisions on land law and the law of trusts. This study reveals that Almarhum Tan Sri Harun M. Hashim had contributed to a vast spectrum of knowledge revolving around land and trusts which is in line with Islam, culture, and values. Tan Sri had addressed and contributed to the development of legal principles in land law including charge, caveat, prohibitory orders, as well as equity and trust principles. Careful consideration of the findings of the review discloses the personal attachment and devotion of the work of Almarhum Tan Sri Harun M. Hashim to the legal development in upholding justice universally as well as to the litigants. As such, the late Tan Sri did not confine his career only as a judge but was also actively involved in and served as a committee member in justice related organisations. The end of his career as a judge saw him continue as an academic, providing a wider platform for him to propagate justice in the preparation of future lawyers and judges.
Қазақстандағы отбасылық және гендерлік саясат ұстанымдары мен оларды қоғам мен мемлекет тарапынан қолдау
Authors: Акыбаева Г.С. , Мусатаев Б.Б. , Мамбетова С.Ш. , Ахметова А.С. , Орынбасаров С.О.
Published: July 2023

Мақсаты: Мақалада Қазақстан Республикасындағы ағымдағы гендерлік үдерістер қоғам мен мемлекет тарапынан қолдау тұрғысынан талданған. Заңнамалық және институционалдық деңгейде гендерлік теңдікке қол жеткізудің негізгі мәселелері, Қазақстан әйелдерінің экономикалық ілгерілеуінің мәселелері айқындалған.

Әдісі: Елімізде гендерлік саясатты тиімді жүзеге асыру үшін институционалдық және нормативтік база құрылған. Қазақстандық қоғам өмірінің барлық салаларында гендерлік теңдікті қамтамасыз ету үшін жоғары мемлекеттік деңгейде гендерлік саясат институты ― Қазақстан Республикасы Президентінің жанындағы Әйелдер істері және отбасылықдемографиялық саясат жөніндегі ұлттық комиссиясының маңызды әдістері қолданылды.

Қорытынды: Мақалада Қазақстан Республикасының Конституциясында және Қазақстан қосылған халықаралық актілерде жарияланған ерлер мен әйелдердің тең құқықтары мен тең мүмкіндіктерін жүзеге асыру, сондай-ақ олардың қоғамның барлық салаларына тең қатысуы үшін жағдай жасау жөнінде ұсыныстар берілген.

Тұжырымдама: Қолданылатын әдістер негізінде Қазақстанның мемлекеттік гендерлік саясаты барлық салаларда барынша гендерлік теңдікті қамтамасыз ететін жаңа қоғамдық қатынастарды құруға мүмкіндік беретін нормаларды, стандарттарды, даму негіздерін, бағыттарын, шектеулері мен бостандықтарын қамтиды. Белгілі бір қоғамда белгілі бір өндіріс тәсілі мен белгілі бір тарихи қатынастар үшін идеялар мен ережелер жүйесі анықталады.
Түркістан облысында инновациялық кәсіпкерлік құрылымдардың қазіргі жағдайы және даму барысы
Authors: Мухамедханова А.Б. , Нурсой М.
Published: July 2023

Мақсаты: Тиімді әлемдік тәжірибе негізінде қазақстандық экономикадағы кәсіпорындардың инновациялық белсенділігін жандандыру бойынша тиісті ұсыныстарды әзірлеу үшін әлемдік және отандық практикада инновациялық кәсіпкерліктің даму мәселелерін зерттеу.
Әдісі: Зерттеу барысында оң, нормативтік, салыстырмалы және жүйелік талдау, синтездеу, жалпылау және ғылыми абстракциялау әдістерінің кешені, сондай-ақ математикалық-статистикалық әдістер қолданылды.
Қорытынды: Инновациялық кәсіпкерлікті дамыту тетігін жетілдіру мәселелерін жеткіліксіз әзірлеу және осы салада жинақталған халықаралық тәжірибені пайдалану дамудың инновациялық жолына көшу тәуекелдерін бағалау, сондай-ақ әлемдік нарыққа шығу кезінде кәсіпкерлік құрылымдардың бәсекелестік артықшылықтарын қалыптастыру тұрғысынан мәселені анықтады.
Тұжырымдама: Инновациялық кәсіпкерлік әлемдік экономиканы дамытудың қазіргі кезеңінде оның құрылымының икемділігі мен бейімделуін арттыруға ықпал жасайды. Ұлттық экономикада инновациялық кәсіпорындар дағдарыс кезеңінде жұмыссыздықтың төмендеуіне ықпал етеді, өнеркәсіп салаларындағы инновациялық процестерді жеделдетеді. Әлемдік экономиканы постиндустриализациялаудың әсерінен бәсекелестіктің күшеюі және өндірістің ұйымдық-технологиялық құрылымының өзгеруі инновациялық шағын және орта кәсіпорындардың рөлін күшейтуге ықпал етеді, өйткені олар аталған өзгерістерге тезірек және ауыртпалықсыз бейімделе алады.
Desulfurization of gas oil using a solar photocatalytic microreactor
Authors: Abid Mohammad Fadhil
Published: July 2023

The present work is devoted to investigate the performance of a homemade Y-shape catalytic microreactor for degradation of dibenzothiophene (DBT), as a model of sulphur compounds including in gas oil, utilizing solar incident energy. The microchannel was coated with TiO2 nanoparticles which were used as a photocatalyst. Performance of the microreactor was investigated using different conditions (e.g., DBT concentration, LHSV, operating temperature, and (H2O2/DBT) ratio). Our experiments show that, in the absence of UV light, no reaction takes place. The results revealed that outlet concentration of DBT decreases as the mean residence time in the microreactor increases. Also, it was noted that operating temperature showed a positive impact on the degradation rate of DBT while LHSV showed a different image. The results reported an optimum (H2O2/DBT) ratio which gave maximum conversion of DBT which vary with initial concentration. Kinetic study was carried out which confirmed that desulfurization of DBT followed a pseudo-first order reaction at 30 and 50oC, respectively. However deviation from linearity was observed at 60oC. Comparison between microreactor´s performance and performance of batch reactors from published literature were illustrated. The Comparison confirmed the unique characteristics of the microreactor.
Study of the Performance of Paraffin Wax as a Phase Change Material in Packed Bed Thermal Energy Storage System
Authors: Naeem Lubna A. , Al-Hattab Tahseen A. , Abdulwahab Majid I.
Published: July 2023

The present work deals with an experimental investigation of charging and discharging processes in thermal storage system using a phase change material PCM. Paraffin wax was used as the PCM which is formed in spherical capsules and packed in a cylindrical packed column which acted as an energy storage system. Air was used as the heat transfer fluid HTF in thermal storage unit. The effect of flow rate and inlet temperature of HTF on the time of charging and discharging process were studied. The results showed that the faster storage of thermal energy can be made by high flow rate of heat transfer fluid HTF and high inlet temperature of heat transfer fluid. It was found that at 65°C HTF inlet temperature, the melting and solidification processes accelerated by 27.9% and 57.14% respectively, when the flow rate was increased from 9 to 24 L/s. Also, when the HTF inlet temperature changed from 65°C to 80°C, the time needed to complete melting process decreased by 38.8%.
Upgrading of Al-Rustamiyah Sewage Treatment Plant Through Experimental and Theoretical Analysis of Membrane Fouling
Authors: Ibrahim Raheek I.
Published: July 2023

Al-Rustamiyah plant is the oldest and biggest sewage treatment plant in Iraq; it locates in the south of Baghdad city. The plant suffers from serious problems associated with overflow and low capacity. The present work aims to upgrade the heart of biological treatment process through suggesting the use of membrane bioreactor; (MBR). In this work, fouling of membrane during sewage treatment has been analyzed experimentally and theoretically by fouling mechanisms. Aeration has been applied in order to control fouling through producing effective diameters of air bubbles close to the membrane walls. Effect of air flow rate on flux decline was investigated. Hermia's models were used to investigate the fouling mechanisms. The results showed that cake formation is the best fitted model (R2≥0.98) followed by intermediate blocking occurred with 9 L/min aeration rate. Cake layer formation is the best fit mechanism in all aeration rates (1-9 L/min) in presence of microalgae. SEM images of the membrane surface before and after filtration showed high density pores membrane surface proved a cake fouling occurring. It was found that aeration represents the most effective technique for fouling domination in addition to its important economic aspects for algae growth and propagation. An enhancement of 70.8% in flux at 9 L/min air flow has been revealed. MBR proved to be more efficient and more convenient than activated sludge since it eliminates the needing of sedimentation tanks and upgrading Al-Rustamiyah plant that has low available space for expansion.
Principlism in bioethics: features and possible limitations
Authors: Boychenko Nataliia
Published: July 2023

Advantages and disadvantages of one of the most influential methodological approaches in bioethics – principlism – are considered. The practical origins of principlism in bioethics and its theoretical origins in the philosophy of principles are revealed. The main philosophical sources of bioethics are indicated, which include utilitarianism, Kantian ethics, rule-based theory of general morality, virtue ethics, and feminist ethics. The irreducibility of principlism to any of these theories in particular and at the same time its appeal to each of them was revealed. In medical ethics, principlism appears primarily as an important practical approach that allows instrumentalization of decision-making in ethically complex situations of treating patients, conducting biomedical and clinical research. The sources of the original four principles, which are recognized by the majority of theorists of principlism, have been clarified. Among such sources, the so-called Belmont report, which names three principles, is of secondary but big importance: the principle of respect for the individual; the principle of beneficence and the principle of justice. The main arguments, classical formulation and typical contexts of application of the four principles of bioethics presented by Tom Beaucamp and James Childress as the generally accepted basis of principlism are presented: respect for autonomy, nonmaleficence, beneficence and justice. European bioethicists subsequently complement and develop these four principles with other principles: dignity, integrity and vulnerability. The main directions of criticism of principlism are revealed: lack of specificity, uncertainty of practical application of ethical theory, possible contradiction between principles. The need for constant and systematic practice of applying ethical principles in making medical decisions is defined as an antidote to these shortcomings of principlism. It is noted that Beaucamp and Childress see such permanent practice through specification and balancing procedures.
Fred Fiedler’s contingency model revisited: 30 years later
Authors: Reams Lester C.
Published: July 2023

A historical review was conducted on Fred Fiedler’s Contingency Model to determine how this model has been used over the past 30 years since 1980. Fred Fiedler’s Contingency Model was created in 1967 to move the field of organizational research from analyzing traits and personal characteristics of leaders to assessing leadership styles and behaviors. The premise of the model is that the individual’s leadership style is the result of their life experiences, making it a fixed characteristic that is extremely difficult to change. Over the years, this model has been used with the aim of improving its validity and reliability in a multitude of national and international organizational settings. The article begins with a brief review of Fiedler’s background, progresses with a detailed description of Fiedler’s Contingency Model, and chronicles Fiedler’s Contingency Model’s use in the past and the present from 1980 to 2022. As a result, two major implications were found. The first implication was that the frequent use of the model had strengthened its validity and reliability, where it was one of the models that were readily used in studies focused on organizational leadership. The second implication was that the findings from these studies were used to address leadership problems that the organization needed to resolve. Based on these implications, it is safe to conclude that this model will continue to be used in future studies, where it will be fascinating to see how the results from Fiedler’s Contingency Model will benefit the organizations moving forward. Challenges facing many workplaces is the issue where supervisors’ leadership style may not fit specific work situation which leads to conflict with their employees. Fiedler’s Contingency Model provides a tool that can be used to identify and place supervisors in the best work situation where the supervisors’ leadership style can be the most effective.
Enhanced Photocatalytic Degradation of Maxillon Blue Dye (GRL) by Using ZnO NPs in Aqueous Solutions
Authors: Said Esraa Ahmed , Hadi Mohammed , Abdullah Hasan Mohammed , Rasen Fadhil A. , Ramadan Montather F.
Published: July 2023

The ZnO nanoparticles (ZnO NPs) catalyst was prepared using the hydrothermal method. Properties of nanoparticles were investigated by utilising some techniques (FE-SEM, TEM, and EDX). The photocatalytic degradation of Maxillon Blue (GRL) under UV irradiation has been studied. The use of zinc oxide as a catalyst in the photo catalysis process under different experimental conditions. The influence of several factors includes the effect of mass catalyst and the concentration of Maxillon blue (GRL) dye. Through the results, the photocatalytic efficiency increases by increasing the weight of the ZnO NPs catalyst starting from 0.1 to 0.4 g per 200 mL, also when the amount of ZnO NPs increased, the rate of degradation goes up first and then keeps unalterable on a certain scale, but when the quantity reaches to 0.4 g per 200 mL, the rate of degradation shows slight change. The highest photodegradation efficiency reaches 87% indicating a good surface activity.
Analysis of transjugular intrahepatic portosystemic shunt by hemodynamic simulation
Authors: Cao Junjie , Yao Zhichao , Huo Guijun , Liu Zhanao , Tang Yao , Huang Jian , Chen Minxin , Ding Rui , Shen Liming , Zhou Dayong
Published: July 2023

BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS), which artificially creates a portocaval shunt to reduce portal venous pressure, has gradually become the primary treatment for portal hypertension (PH). However, there is no prefect shunting scheme in TIPS to balance the occurrence of postoperative complications and effective haemostasis. OBJECTIVE: To construct cirrhotic PH models and compare different shunting schemes in TIPS. METHODS: Three cases of cirrhotic PH with different liver volumes were selected for enhanced computed tomography scanning. The models for different shunting schemes were created using Mimics software, and following FLUENT calculation, all the models were imported into the software computational fluid dynamic-post for processing. In each shunting scheme, the differences in portal vein pressure, hepatic blood perfusion and blood flow from the superior mesenteric vein in the shunt tract were compared. The coefficient G was adapted to evaluate the advantages and disadvantages. RESULTS: (1) Concerning the precise location of the shunt tract, the wider the diameter of the shunt tract, the lower the pressure of the portal vein and the lesser the hepatic blood perfusion. Meanwhile, the pressure drop objective was not achieved with the 6 mm-diameter shunting scheme. (2) The 8 mm-diameter shunting scheme through the left portal vein (LPV) had the highest coefficient G. CONCLUSION: The 8 mm-diameter shunting scheme through the LPV may demonstrate a superior effect and prognosis in TIPS procedures.
Liver cancer classification via deep hybrid model from CT image with improved texture feature set and fuzzy clustering based segmentation
Authors: Tejaswi Vinnakota Sai Durga , Rachapudi Venubabu
Published: July 2023

One of the leading causes of death for people worldwide is liver cancer. Manually identifying the cancer tissue in the current situation is a challenging and time-consuming task. Assessing the tumor load, planning therapies, making predictions, and tracking the clinical response can all be done using the segmentation of liver lesions in Computed Tomography (CT) scans. In this paper we propose a new technique for liver cancer classification with CT image. This method consists of four stages like pre-processing, segmentation, feature extraction and classification. In the initial stage the input image will be pre processed for the quality enhancement. This preprocessed output will be subjected to the segmentation phase; here improved deep fuzzy clustering technique will be applied for image segmentation. Subsequently, the segmented image will be the input of the feature extraction phase, where the extracted features are named as Improved Gabor Transitional Pattern, Grey-Level Co-occurrence Matrix (GLCM), Statistical features and Convolutional Neural Network (CNN) based feature. Finally the extracted features are subjected to the classification stage, here the two types of classifiers used for classification that is Bi-GRU and Deep Maxout. In this phase we will apply the Crossover mutated COOT optimization (CMCO) for tuning the weights, So that we will improve the quality of the image. This proposed technique, present the best accuracy of disease identification. The CMCO gained the accuracy of 95.58%, which is preferable than AO = 92.16%, COA = 89.38%, TSA = 88.05%, AOA = 92.05% and COOT = 91.95%, respectively.
Effects of a behavior-based safety observation program: Promoting safe behaviors and safety climate at work
Authors: Yang Eunhwa , Kim Yujin , Rodgers Charner
Published: July 2023

BACKGROUND: Behavior-based safety (BBS) programs promote coworkers observing and correcting each other’s at-risk behaviors on site; the idea behind BBS programs is to create a cultural shift in a company where it is acceptable for coworkers to stop anyone, at any time, from working in an unsafe manner. OBJECTIVE: The main objective of this study is to examine the impacts of a BBS observation program in the construction industry. METHODS: The subject, an electrical contracting company, implemented the BBS program in January 2019. This study utilized multiple data sources: the company’s incident data, BBS program report data, and surveys, including the Safety Climate Assessment Tool for Small Contractors. A total of 3,891 at-risk behaviors from the BBS reports, including 600 comments, and 141 survey responses were analyzed. RESULTS: The most frequently reported at-risk behavior was the line of fire, and the at-risk behaviors were often observed when workers conducted tasks, such as running or pulling wires, installing devices, and installing lights. The overall perception of safety climate was high, and the respondents reported that the safety climate had improved since the adoption of the BBS program. Overall, implementing the BBS program benefited in cultivating the company’s collective safety climate. CONCLUSION: As a result of the BBS program, the company implemented better communication strategies for their safety meetings on the most frequently reported at-risk behaviors, replacing safety gears with higher quality ones, and redesigning online safety training to better reflect the identified tasks that were associated with more at-risk behaviors.
THE CONCEPT OF CRYPTOCURRENCY IN ISLAM
Authors: Fajaruddin Achmad , Azizy Dimas Fahmi , Parojai M. Ridhauli Pasha , Husni Indra Sholeh , Tambusai Muhamad Kharis
Published: July 2023

Digital money obtained by converting physical money into digital is often used in electronic transactions. However, modern technology has also produced virtual currencies, known as cryptocurrencies. Bitcoin and other cryptocurrencies are unregulated and have not received official approval by Indonesian law. Research to know and analyze the concept of crypto according to Islam. With the method of literature review combined with bibliometric analysis. Data was collected using Publish or Perish (PoP) software from the Google Scholar database. Table 1 shows the number of author citations for works discussing cryptocurrencies and Islamic studies. Based on search results obtained by PoP software. The number of citations from authors who have more than 10 citations is calculated from the total number of authors. Use keywords as a foundation. Nine clusters were found as a result of keyword mapping: red, blue, yellow, green, purple, orange, brown, and pink.
PANDANGAN MAQASID SYARIAH DALAM PENGELOLAAN DANA HAJI MELALUI SUKUK
Authors: Ndraha Gina Maulida , Marliyah Marliyah , Arif Muhammad
Published: July 2023

From the results of the analysis of this study it was found that the Hajj funds managed by the Ministry of Finance were combined with funds from debt financing sources which then entered into the state treasury which was allocated to debt financing in the budget financing section which functioned to cover short-term cash shortages where cash differences appeared when the available state treasury is unable to suffice for expenditures that cannot be postponed. The effectiveness of the management of the Hajj funds can be seen from the improvement in the quality of organizing the Hajj (lodging, catering and transportation) and the Cost of Organizing the Hajj (BPIH). With BPIH in 2018 of Rp. 31 million pilgrims have received the best facilities with 3 star accommodation, safe and secure transportation and timely catering, clean and healthy food is also delivered according to time and portion. This is proof that the management of haj funds at SDHI is effective because the results of these yields can cover half of the service needs and costs of Indonesian haj.
BANKING SYSTEM OF UKRAINE: STATUS AND DEVELOPMENT TRENDS
Authors: Andrieieva Olena
Published: July 2023

s an important component of the financial market, the banking system of Ukraine provides conditions for the effective functioning of the entire economic system of the country. Traditionally, the task of the banking system is the concentration of monetary resources with their subsequent redistribution among business entities, households, and industries. By fulfilling this task, the banking system actually contributes to the economic development of the state.In 2022, with the beginning of the war, the national banking system was faced simultaneously with problems of a general economic internal nature caused by the war: a reduction in production and income from the export of industrial and agricultural products, devaluation of the national currency, an increase in security risks, mass migration of the population and problems of a global nature -this is a slowdown in the development of the world economy. In these conditions, the National Bank of Ukraine, as the regulator of the money market, was forced to switch to a strict model of monetary policy, the goal of which was, first of all, to maintain the rate of inflation and exchange rate stability, and the main "recipes" for improving the money market were to increase the discount rate and mandatory reserve norms for commercial banks. The transition to a restrictive monetary policy is always a test for banks, but. the timely application of restrictive measures made it possible to maintain control over the currency market, over price dynamics, and give a positive forecast for economic growth.Activity in the conditions of war and economic uncertainty became a reality for the banking system and a basis for the formation of further development trends.In the medium-term perspective, the main trends in the development of the banking sector include the NBU's continued strict monetary policy and the strengthening of market incentives for banks to attract long-term hryvnia deposits from individuals; dominance of credit risks in banking; significant investments by commercial banks in high-yield certificates of the NBU and Domestic state loan bonds with the aim of increasing interest income; gradual decrease in liquidity in the banking sector; slowing of inflation as a result of the reduction of security factors; the return of banks to their pre-war business models with the simultaneous search for new forms of lending and the formation of an effective anti-crisis model of bank regulation
ADAPTIVE STRATEGIC PLANNING AS AN EFFECTIVE TOOL FOR THE DEVELOPMENT OF BUSINESS STRUCTURES IN THE FACE OF MODERN CHALLENGES
Authors: Kovbatiuk Maryna
Published: July 2023

In today's fast-changing and unpredictable business environment, organizations face numerous challenges that require them to be flexible, responsive and proactive. Traditional approaches to strategic planning often fail to cope with thecomplexities and uncertainties of the modern business environment. Adaptive strategic planning, on the other hand, offers a dynamic and flexible framework that allows organizations to effectively address these challenges. Adaptive strategic planning performs important functions in business structures by facilitating proactive decision-making, providing flexibility and agility, and promoting organizational learning and adaptation.In addition, adaptive strategic planning is a tool for ensuring the economic security of an enterprise. It provides a framework that allows companies to anticipate and respond to changes, mitigate risks and ensure their economic security. Adaptive strategic planning allows organizations to identify potential risks, develop contingency plans, and build resilience into their business models. By considering different scenarios and preparing for different outcomes, businesses can more easily cope with disruptions and uncertainties. This resilience ensures their ability to continue operations, maintain profitability and protect their economic security in the face of adverse events.Adaptive strategic planning promotes a culture of continuous learning and improvement in organizations. It encourages employees at all levels to share their knowledge, ideas, and experiences. By creating an environment that values experimentation, feedback, and collaboration, companies can tap into the collective intelligence of their workforce. This fosters innovation, adaptability, and resilience, positioning the organization for sustainable success in the face of today's challenges. Adaptive strategic planning is a vital tool for the development of business structures in today's dynamic and unpredictable environment. It allows organizations to proactively respond to change, capitalize on new trends, and drive long-term growth and success. With flexibility, agility, and a culture of continuous learning, businesses can meet today's challenges and thrive in an ever-changing environment.
Miyelom Zimba Gibi Gelir: Roy Adaptasyon Modeli Bir Olgu Sunumu
Authors: KARACAN Yasemin , YILDIZ Hicran , ALİ Rıdvan
Published: July 2023

Multiple miyelomlu bireylerde semptom yönetimi, kemik hastalığı ve böbrek fonksiyon bozukluğuna bağlı semptomlar başta olmak üzere, enfeksiyon, anemi, ağrı ve pıhtılaşma bozukluğu gibi spesifik sorunları içermektedir. Diğer hastalıklarda olduğu gibi, miyelomlu hastanın tanı ve tedavi sürecinde hemşirelik bakımı önemli bir yer tutmaktadır. Hemşirelik bakım modelleri hastanın sistematik ve kapsamlı şekilde ele alınmasını sağlayarak bakımının kalitesinin arttırılmasına katkıda bulunmaktadır. Roy Adaptasyon Modeli bunlardan biridir. Roy Adaptasyon modelinde fizyolojik, benlik kavramı, rol fonksiyonu ve karşılıklı bağlılık olmak üzere dört uyum alanı vardır ve hemşireler hastalarına bu uyum alanları doğrultusunda bakım vermektedir. Olgu sunumunda, bel ağrısı nedeniyle başvuran radyolojik, laboratuvar, sitogenetik ve kliniği ile Durie Salmon’a göre lambda hafif zincir, evre III B multiple miyeloma tanısı almış ve ayaktan kemoterapi tedavi planı hazırlanmış bir hasta ele alınmaktadır. Bu olgu sunumu, Multiple miyelomlu bir hastaya Roy Adaptasyon Modeli doğrultusunda verilen bakımın North American Nursing Diagnosis Association hemşirelik tanılarıyla birlikte ele alınması konusunda, hematoloji ve onkoloji alanında çalışan hemşirelere rehber olmak amacıyla hazırlanmıştır.
Intra-amniotic sildenafil treatment improves lung blood flow and pulmonary hypertension in congenital diaphragmatic hernia rats
Authors: Yoshida Shiho , Kreger Alexander M. , Gittes George K.
Published: July 2023

Pulmonary hypertension associated with congenital diaphragmatic hernia (CDH) is a critical factor in determining prognosis. We propose that intra-amniotic sildenafil administration is an effective prenatal therapy for CDH-induced pulmonary hypertension. To assess the efficacy of this treatment, we administered sildenafil to nitrofen-induced congenital diaphragmatic hernia fetuses and control fetuses via an intra-amniotic injection after a laparotomy on the pregnant dam at either E13.5 or E15.5. Intra-amniotic sildenafil treatment attenuated peripheral vascular muscularization, enhanced pulmonary blood flow, and increased the ratio of pulmonary artery size to aortic size in congenital diaphragmatic hernia fetuses after both E13.5 and E15.5 treatments. E13.5-treated congenital diaphragmatic hernia fetuses showed a higher and more prolonged expression of cyclic guanosine monophosphate (cGMP)-dependent protein kinase and more production of vascular endothelial growth factor, resulting in a significant improvement in lung architecture. The E13.5-treated congenital diaphragmatic hernia fetuses also had an increase in lung weight-to-body weight ratio and an improved fetal survival. Intra-amniotic sildenafil treatment did not show any detectable negative effects in control fetuses. Intra-amniotic sildenafil treatment for rats attenuates CDH-induced pulmonary hypertension and enhanced peripheral pulmonary blood flow. Moreover, early intervention may be preferable to better accelerate lung development and improve prognosis. Direct sildenafil administration via an intra-amniotic injection may be a promising option in congenital diaphragmatic hernia prenatal therapy.
Retrograde type A aortic dissection during or after thoracic endovascular aortic repair: a single center 16-year experience
Authors: Wang Guo-quan , Qin Ya-fei , Shi Shuai-tao , Zhang Ke-wei , Zhai Shui-ting , Li Tian-xiao
Published: July 2023

Objective

This article aims to investigate the incidence rate of retrograde type A aortic dissection (RTAD) and the risk factors of RTAD in relation to thoracic endovascular aortic repair (TEVAR).

Methods

Patients with thoracic aortic disease who underwent TEVAR at Henan Provincial People's Hospital from January 2004 to December 2019 were enrolled in the present research. The risk factors associated with RTAD following TEVAR using univariate and multiple logistic regression analyses.

Results

During the study period, A total of 1,688 TEVAR patients were included in this study, and of these, 1,592 cases were included in the type B aortic dissection (TBAD) group, and 96 cases were included in the non-TBAD group. There were 1,230 cases of aortic dissection and 362 cases of aortic intramural hematoma and/or penetrating ulcer in the TBAD group. The non-TBAD group included 68 cases of thoracic aortic aneurysm, 21 cases of thoracic aortic pseudoaneurysm, and seven cases of congenital aortic coarctation. The overall incidence rate of RTAD was 1.1% (18/1,688) in patients, all of which occurred in the TBAD group. The cohort comprised 18 RTAD patients with an average age of 56.78, consisting of 13 males and 5 females. Among them, 13 individuals exhibited hypertension. Ten instances happened within the TEVAR perioperative period, including two cases during the surgery, six cases occurred within three months, two cases occurred after one year, and the longest interval was 72 months following TEVAR. TEVAR was successfully implemented in 17 patients, while the operation technique was temporarily altered in one case. The new entry position for RTAD was identified as the proximal region of the stent graft (SG) in 13 patients, while in five cases, the entry site was more than 2 cm away from the proximal region of the SG. 17 cases were at the greater curvature of the aorta, and one case was at the lesser curvature. Multivariate logistic regression analysis revealed that the SG oversizing ratio is a relevant risk factor for RTAD. However, ascending aortic diameter, aortic arch type, SG type, and anchored region were not directly related to the occurrence of RTAD.

Conclusion

RTAD is a rare yet catastrophic complication. It could occur both during the procedure, early and late postoperative periods. Maintaining an appropriate SG oversizing ratio is crucial to minimize the risk of RTAD.
Jazz and improvising: experiences, attitudes and beliefs of United Kingdom (UK) secondary school music teachers: listening for gender
Authors: Black Pauline
Published: July 2023

It is well documented that jazz has a male hegemonic narrative. Researchers have also found gender injustices in performance and in education. Recent research has shown that there have been pioneering female jazz musicians around through many eras, however women have traditionally been under-represented in historical jazz narratives and they remain a minority in the field of jazz. This contrasts sharply with the fact that music teaching in schools in the United Kingdom (UK) is a profession occupied predominantly by women. Jazz and improvising occupy a marginal place in the curricula in schools across all four nations in the United Kingdom (UK). Studies show that in the secondary school music curriculum there is generally a focus on technical development, musical skill building and reproduction, rather than creative activities such as improvising and composing. There are resultant tensions between the performativity and creativity agendas found in schools and issues of teacher agency, freedom and control are prominent. This mixed methods study of secondary school music teachers (classroom and instrumental) investigates their experiences, attitudes and beliefs in relation to jazz and improvising in their practice. The data show that gender is a significant factor when considering amount and type of activity, as well as confidence and anxiety in jazz and improvising. Barriers exist for women and girls in schools that need to be addressed if changes in gender participation in jazz and improvising are to happen. The study provides implications for future educational practice in order that gender inequities might be addressed.
mDIXON-Quant for differentiation of renal damage degree in patients with chronic kidney disease
Authors: Wang Yue , Ju Ye , An Qi , Lin Liangjie , Liu Ai Lian
Published: July 2023

Background

Chronic kidney disease (CKD) is a complex syndrome with high morbidity and slow progression. Early stages of CKD are asymptomatic and lack of awareness at this stage allows CKD to progress through to advanced stages. Early detection of CKD is critical for the early intervention and prognosis improvement.

Purpose

To assess the capability of mDIXON-Quant imaging to detect early CKD and evaluate the degree of renal damage in patients with CKD.

Study type

Retrospective.

Population

35 patients with CKD: 18 cases were classifified as the mild renal damage group (group A) and 17 cases were classifified as the moderate to severe renal damage group (group B). 22 healthy volunteers (group C).

Field strength/sequence

A 3.0 T/T1WI, T2WI and mDIXON-Quant sequences.

Assessment

Transverse relaxation rate (R2*) values and fat fraction (FF) values derived from the mDIXON-Quant were calculated and compared among the three groups.

Statistical tests

The intra-class correlation (ICC) test; Chi-square test or Fisher’s exact test; Shapiro-Wilk test; Kruskal Wallis test with adjustments for multiplicity (Bonferroni test); Area under the receiver operating characteristic (ROC) curve (AUC). The significance threshold was set at P < 0.05.

Results

Cortex FF values and cortex R2* values were significantly different among the three groups (P=0.028, <0.001), while medulla R2* values and medulla FF values were not (P=0.110, 0.139). Cortex FF values of group B was significantly higher than that of group A (Bonferroni adjusted P = 0.027). Cortex R2* values of group A and group B were both significantly higher than that of group C (Bonferroni adjusted P = 0.012, 0.001). The AUC of cortex FF values in distinguishing group A and group B was 0.766. The diagnostic efficiency of cortex R2* values in distinguishing group A vs. group C and group B vs. group C were 0.788 and 0.829.

Conclusion

The mDIXON-Quant imaging had a potential clinical value in early diagnosis of CKD and assessing the degree of renal damage in CKD patients.
Re-appraisal of the global climatic role of natural forests for improved climate projections and policies
Authors: Makarieva Anastassia M. , Nefiodov Andrei V. , Rammig Anja , Nobre Antonio Donato
Published: July 2023

Along with the accumulation of atmospheric greenhouse gases, particularly carbon dioxide, the loss of primary forests and other natural ecosystems is a major disruption of the Earth's system and is causing global concern. Quantifying planetary warming from carbon emissions, global climate models highlight natural forests' high carbon storage potential supporting conservation policies. However, some model outcomes effectively deprioritize conservation of boreal and temperate forests by suggesting that increased albedo upon deforestation could cool the planet. A potential conflict of global cooling vs. regional forest conservation could harm environmental policies. Here we present theoretical and observational evidence to demonstrate that, compared to the carbon-related warming, modeling skills for assessing climatic impacts of deforestation is low. We argue that estimates for deforestation-induced global cooling result from the models' limited capacity to account for the global effect of cooling from evapotranspiration of intact forests. Specifically, transpiration of trees can change the greenhouse effect via small modifications of the vertical temperature profile. However, due to their convective parameterization (which postulates a certain critical temperature profile), global climate models do not properly capture this effect. This may lead to an underestimation of warming from the loss of forest evapotranspiration in both high and low latitudes. As a result, conclusions about deforestation-induced global cooling are not robust and could result in action that immediately worsened global warming. To avoid deepening the environmental crisis, these conclusions should not inform policies of vegetation cover management, especially as studies from multiple fields are accumulating that better quantify the stabilizing impact of natural ecosystems evolved to maintain environmental homeostasis. Given the critical state and our limited understanding of both climate and ecosystems, an optimal policy with immediate benefits would be a global moratorium on the exploitation of all natural forests.
NVX-CoV2373-induced T- and B-cellular immunity in immunosuppressed people with multiple sclerosis that failed to respond to mRNA and viral vector SARS-CoV-2 vaccines
Authors: Mueller-Enz Magdalena , Woopen Christina , Katoul Al Rahbani Georges , Haase Rocco , Dunsche Marie , Ziemssen Tjalf , Akgün Katja
Published: July 2023

Importance

Immunological response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is important, especially in people with multiple sclerosis (pwMS) on immunosuppressive therapies.

Objective

This study aims to determine whether adjuvanted protein-based vaccine NVX-CoV2373 is able to induce an immune response to SARS-CoV-2 in pwMS with inadequate responses to prior triple mRNA/viral vector vaccination.

Design, setting, and participants

We conducted a single-center, prospective longitudinal cohort study at the MS Center in Dresden, Germany. In total, 65 participants were included in the study in accordance with the following eligibility criteria: age > 18 years, immunomodulatory treatment, and insufficient T-cellular and humoral response to prior vaccination with at least two doses of SARS-CoV-2 mRNA (BNT162b2, mRNA-1273) or viral vector vaccines (AZD1222, Ad26.COV2.S).

Interventions

Intramuscular vaccination with two doses of NVX-CoV2373 at baseline and 3 weeks of follow-up.

Main outcomes and measures

The development of SARS-CoV-2-specific antibodies and T-cell responses was evaluated.

Results

For the final analysis, data from 47 patients on stable treatment with sphingosine-1-phosphate receptor (S1PR) modulators and 17 on ocrelizumab were available. The tolerability of the NVX-CoV2373 vaccination was overall good and comparable to the one reported for the general population. After the second NVX-CoV2373 vaccination, 59% of S1PR-modulated patients developed antispike IgG antibodies above the predefined cutoff of 200 binding antibody units (BAU)/ml (mean, 1,204.37 [95% CI, 693.15, 2,092.65] BAU/ml), whereas no clinically significant T-cell response was found. In the subgroup of the patients on ocrelizumab treatment, 23.5% developed antispike IgG > 200 BAU/ml (mean, 116.3 [95% CI, 47.04, 287.51] BAU/ml) and 53% showed positive spike-specific T-cellular responses (IFN-gamma release to antigen 1: mean, 0.2 [95% CI, 0.11, 0.31] IU/ml; antigen 2: mean, 0.24 [95% CI, 0.14, 0.37]) after the second vaccination.

Conclusions

Vaccination with two doses of NVX-CoV2373 was able to elicit a SARS-CoV-2-specific immune response in pwMS lacking adequate immune responses to previous mRNA/viral vector vaccination. For patients receiving S1PR modulators, an increase in anti-SARS-CoV-2 IgG antibodies was detected after NVX-CoV2373 vaccination, whereas in ocrelizumab-treated patients, the increase of antiviral T-cell responses was more pronounced. Our data may impact clinical decision-making by influencing the preference for NVX-CoV2373 vaccination in pwMS receiving treatment with S1PR modulation or anti-CD20 treatment.
Oral prednisolone suppresses skin inflammation in a healthy volunteer imiquimod challenge model
Authors: Assil Salma , Buters Thomas P. , Hameeteman Pieter W. , Hallard Charlie , Treijtel Nicoline , Niemeyer – Van der Kolk Tessa , de Kam Marieke L. , Florencia Edwin F. I. I. I. , Prens Errol P. , van Doorn Martijn B. A. , Rissmann Robert , Klarenbeek Naomi B. , Jansen Manon A. A. , Moerland Matthijs
Published: July 2023

Imiquimod (IMQ) is a topical agent that induces local inflammation via the Toll-like receptor 7 pathway. Recently, an IMQ-driven skin inflammation model was developed in healthy volunteers for proof-of-pharmacology trials. The aim of this study was to profile the cellular, biochemical, and clinical effects of the marketed anti-inflammatory compound prednisolone in an IMQ model. This randomized, double-blind, placebo-controlled study was conducted in 24 healthy volunteers. Oral prednisolone (0.25 mg/kg/dose) or placebo (1:1) was administered twice daily for 6 consecutive days. Two days after treatment initiation with prednisolone or placebo, 5 mg imiquimod (IMQ) once daily for two following days was applied under occlusion on the tape-stripped skin of the back for 48 h in healthy volunteers. Non-invasive (imaging and biophysical) and invasive (skin punch biopsies and blister induction) assessments were performed, as well as IMQ ex vivo stimulation of whole blood. Prednisolone reduced blood perfusion and skin erythema following 48 h of IMQ application (95% CI [−26.4%, −4.3%], p = 0.0111 and 95% CI [−7.96, −2.13], p = 0.0016). Oral prednisolone suppressed the IMQ-elevated total cell count (95% CI [−79.7%, −16.3%], p = 0.0165), NK and dendritic cells (95% CI [−68.7%, −5.2%], p = 0.0333, 95% CI [−76.9%, −13.9%], p = 0.0184), and classical monocytes (95% CI [−76.7%, −26.6%], p = 0.0043) in blister fluid. Notably, TNF, IL-6, IL-8, and Mx-A responses in blister exudate were also reduced by prednisolone compared to placebo. Oral prednisolone suppresses IMQ-induced skin inflammation, which underlines the value of this cutaneous challenge model in clinical pharmacology studies of novel anti-inflammatory compounds. In these studies, prednisolone can be used as a benchmark.