bluuebunny/crossref_metadata_2025 huggingface dataset:
Resolution Des Problemes Mathematiques En Formation Et Applications
Authors: M’hamed Sbaa Mohammed et El aydi , Said Yadir , Bouchaib Radi
Published: September 2017

Mathematics occupies a privileged place in the educational system. It is one of the main disciplines in a learner's school life that allows him to develop problem-solving strategies and different learning abilities. Indeed, it is very important to make the learner to become active in the learning process of Mathematics. As a result, problem solving has become a crucial aspect. It helps the learner in the development of strategies for problem solving. Also, the learner must be adaptive to new situations from other disciplines or everyday life. In this study, we used the Georges Polya's "How solve it" guide and we applied it to solving some problems by insisting on the importance of applications in the teaching of Mathematics. We talked about the definition of the open problem and its educational objectives according to the IREM of Lyon. Then we discussed the activities by describing some difficulties encountered by the trainee teachers. These activities include: (1) A problem solved by three different methods: analytical geometry, GeoGebra software, and the Maple software to make a comparison of methods by practice; (2) Solving some open problems. We concluded this study by implementing problem-solving strategies and reasoning methods as tools for trainee teachers for "solving some open problems".
PENGARUH CORPORATE GOVERNANCE PERCEPTION INDEX,MANAJEMEN LABA, DAN TIPE INDUSTRITERHADAP ENVIRONMENTAL DISCLOSURE
Authors: Chrysanti Amanda , Noviarini Diena
Published: September 2017

Thisresearchaims to empirically analyze the influence ofCorporate Governance Perception Index, earnings management,and industry type on environmental disclosure. Environmental Disclosure is the dependent variables in this research were measured by scoring technique based on GRI3.1 Guidelines. For the independent variables in this research, using Corporate Governance Perception Index were measured by CGPI index score, earnings management were measured by discretionary accruals, and industry type were measured bycategorial. This research uses secondary data which population are companies entered Corporate Governance Perception Index  in 2009-2012. While the sampling method used was purposive sampling method which is overall 44 sample choose. This research uses multiple regression method to test the hypothesis with SPSS computer program. From the analysis performed in this research, it can be concluded that Corporate Governance Perception Index has positively and significant influence to environmental disclosure. The other hand earnings management has no significant influence  to  environmental  disclosure.  The  last  one  industry  type  has  negatively  and  significant  influence  to environmental disclosure.

 

Key  Words:  Corporate  Governance  Perception  Index,  Earnings  Management,  Industry  Type,  and  Environmental Disclosure
ANALISIS KESEHATAN BANK MANDIRI DAN BANK BCADENGAN METODE RGEC TAHUN 2010-2014
Authors: Rahayu Dwi , Suhendro Suhendro
Published: September 2017

This study aims to determine the health level of Bank Mandiri and Bank BCA method RGEC 2010-2014. Descriptive research with quantitative approach. This study assesses the risk profile factors through NPL ratio and LDR, GCG factor, earnings factor through ROA, ROE, NIM and ROA, and the factor of capital through the CAR. Results of the study factors the Bank's risk profile has an average NPL of 2.1%, and the average LDR of 69.56%, while the value of BCA Bank NPL 0.51%, and 67.21% of its value LDR. Factors overall GCG shows the bank is able to meet the eleven aspects of GCG with the average received the title very well. Assessment assessed earnings of ROA, ROE, NIM and ROA Bank BCA has a better rating than the bank. Capital factor assessed with the CAR ratio of Bank Mandiri has an average of 18,06%, while 17,19% of BCA Bank. Thus, if judged by the factor capital, the bank has better performance than the BCA.

 

Keywords: Health of Banks, RGEC
BIAS JENDER DALAM MATERI AJAR AQIDAH AKHLAK DI MADRASAH IBTIDAIYAH: Studi Analisis Bias Jender pada Bahasa dan Gambar
Authors: Farikhah Siti
Published: September 2017

Penelitian ini bertujuan untuk mengidentifikasi bias jender pada gambar dan bahasa yang terdapat pada materi ajar Aqidah Akhlak di Madrasah Ibtidaiyah. Pemilihan buku ajar Madrasah Ibtidaiyah yang berperspektif jender adalah tindakan yang tepat, agar kekeliruan pola pikir kognitif dan bentukan afektif maupun psikomotoriknya tidak terlanjur jauh terinternalisasi dari kecakapan, sikap dan perilaku peserta didik. Jenis penelitian ini adalah kualitatif deskrptif. Populasi penelitian ini adalah buku ajar pada mata pelajaran Aqidah Akhlak kelas 1, 2, 3, 4, 5 dan 6 yang digunakan di Madrasah Ibtida­iyah di kota Salatiga, Kabupaten Magelang dan Kabupaten Pono­rogo. Pengambilan sampel menggunakan teknik purposive random sampling, yaitu berupa buku ajar Aqidah Akhlak yang di­keluarkan oleh beberapa penerbit yang terbanyak digunakan MI di ketiga kota ter­sebut. Teknik pengumpulan data dilakukan dengan cara meng­amati (observasi) secara cermat, yaitu mengidentifikasi ada tidaknya bias jender berdasarkan instrumen yang berupa lembar identifikasi bias jender yang berisi tentang paparan gambar-gambar dan kalimat-kalimat yang menunjukkan bias jender pada peran jender seperti peran produktif, reproduktif dan sosial. Teknik analisis data dalam penelitian ini menggunakan teknik analisis isi (content analysis), sarana tanda (sign-vechile) dan analisis wacana. Hasil penelitian terhadap gambar pada materi ajar Aqidah Akhlak mulai dari kelas 1 sampai dengan kelas 6, sebagian besar perempuan masih digambarkan pada gambar yang kecil dibandingkan dengan gambar jenis kelamin yang lain, diletakkan pada posisi dibelakang, masih mendapatkan peran yang kurang signifikan bahkan mendiskriditkan perempuan antara lain beberapa sikap negatif yang dilekatkan pada jenis kelamin perempuan. Pelabelan atau steriotipe terhadap per­empuan bahwa perempuan itu makhluk yang lemah, marginalisasi terhadap perempuan sehingga banyak digambarkan bahwa per­empu­an hanya bertindak sebagai pelayan keluarga, istri yang hanya melayani suami dan anak-anaknya, subordinasi terhadap hak per­empuan untuk menjadi anak yang pintar seperti juara kelas, sekolah, mencari nafkah masih jelas terlihat. Selain itu frekuensi gambar yang sering muncul dimasing-masing pelajaran masih didominasi oleh laki-laki. 
MENGOBATI LUKA ANAK KORBAN PERCERAIAN MELALUI PEMAAFAN
Authors: Hikmah Siti
Published: September 2017

Stress bias terjadi dimanapun, kapanpun, dan bagaimanapun. Salah satu stress dirasakan oleh anak-anak. Sebagian besar anak yang tumbuh dalam keluarga yang bercerai akan mengalami stress berat beresiko mengembangkan masalah masalah perilaku misalnya juvenil delequency, mall adjusment dll. Pemaafan sangat dibutuhkan bagi anak untuk mengelola dan menanggulangi disstres yang dirasakan. Alur yang ditawarkan oleh pemaafan mengarahkan anak untuk menekankan jalan damai dan cinta kasih untuk mengatasi rasa sakit yang dialami. Anak tidak lagi menimpakan beban kesalahan pada orang lain, dan dapat melihat bahwa hal yang lebih penting adalah berusaha mencapai perasaan dan kondisi damai itu sendiri. Perlu upaya mengurangi perasaan dengan menggunakan faktor analisis, mendapatkan tiga aspek kesiapan memaafkan, yaitu pemaafan versus balas dendam, situasi pribadi dan sosial, dan halangan terhadap pemaafan. 

 
SEKSISME DALAM SAINS
Authors: Salama Nadiatus
Published: September 2017

Seksisme telah terjadi sejak lama yang dilakukan oleh kelompok yang tidak mengakui kesetaraan jender. Meskipun diskri­minasi ini merupakan hal yang buruk dan berlawanan dengan hu­kum, namun perilaku ini masih eksis, dan mendarah daging dalam pe­mikiran, sikap dan tindakan sebagian masyarakat yang sudah modern ini. Sejumlah sains dan riset turut digunakan untuk mem­benarkan sejumlah keyakinan yang seksisme, pada­hal, telah ter­jadi bias dan mis-inter­pretasi dalam riset ter­sebut. Per­empuan dilihat sebagai suatu sosok yang menjadi masalah oleh sains. Itulah sebabnya, saat ini, per­empuan ber­suara lebih keras dalam mem­perjuang­kan hak-hak­nya daripada pada masa sebelumnya, berharap agar segera dihenti­kan dan tidak berlarut-larut. Melawan sek­sisme bisa di­lakukan secara individu maupun kolektif, de­ngan cara me­lapor­kan diskriminasi yang terjadi, atau juga mem­berikan pe­nyuluhan atau pendidik­an tentang seksisme agar dis­kriminasi ini tidak menjadi lebih parah lagi. Di sisi lain, negara, sebagai insti­t­usi resmi pelindung warganya, juga wajib menjadi peng­ayom dan pembela korban seksisme.
Usulan Perawatan Sistem Boiler dengan Metode Reliability Centered Maintenance (RCM)
Authors: Rachman Hamim , Garside Annisa Kesy , Kholik Heri Mujayin
Published: September 2017

Pembangkit Listrik Tenaga Uap (PLTU) PT Indo Pusaka Berau is a PLN work unit that provides electricity to consumers. The problem of the company is the frequent damage to boiler engine components. The company uses corrective maintenance system. On the problem, it is necessary to develop a machine maintenance system with Reliability Centered Maintenance (RCM) approach. The objective of the study was to select a boiler system maintenance action based on the RCM method and component replacement interval to minimize Total Minimum Downtime (TMD). Results of data processing RCM method, component in category Condition Directed (CD) is El Bow component. Components in Time Directed category (TD) are gland seal steam and check valve. Components in the Time Directed category are calculated for component replacement intervals on TMD criteria. The calculation result from component replacement interval was obtained 37 days for gland seal steam component and 58 days for check valve component. The proposed treatment of RCM method can reduce downtime by 11.33% of the company's maintenance methods.
Las intervenciones de los parlamentarios socialistas argentinos en la Cámara de Diputados de la Nación: la cuestión nacional en su dimensión política, 1912-1917
Authors: Costa Flavio
Published: September 2017

El presente trabajo explora la idea de nación que poseía el Partido Socialista argentino, a través de la intervención de su bloque parlamentario en la Cámara de Diputados de la Nación  durante el período de 1912 a 1917. En ese sentido, el recorrido por las fuentes nos permite repensar la cuestión desde una perspectiva particular: el nacionalismo en su dimensión política teniendo en cuenta aquellas discusiones parlamentarias donde los socialistas se hayan destacado. En ese marco, estos construyen una idea resignificada de nación donde converge un discurso nacionalista liberal apoyado en el precepto de ciudadanía, con una noción evolucionista de la nación cuya última etapa es la lucha entre clase obrera y clase capitalista. Para los socialistas, la lucha de clases era un fenómeno inevitable en el desarrollo del proceso histórico nacional y condición necesaria para lograr un nacionalismo pleno.
COLONIZATION of Rubus glaucus BENTH BY AZORHIZOBIUM CAULINODANS ORS571 USIG A FLAVONOIDE NARINGENINA
Authors: Cancino Escalante Giovani Orlando , Cancino S E , Quevedo Garcia Enrique
Published: September 2017

Root systems of two Andean blackberry materials (thorn and thornless) of Rubus glaucus Benth cultured in vitro in the presence of five treatments (four flavonoids and one control) were inoculated with Azorhizobium caulinodans ORS571 (pXLGD4)  (a strain carrying the lacZ reporter gene which facilitated the detection of bacterial colonization). Evaluation of colonization effectiveness for each treatment was done by means of application of experimental design measuring frequency and intensity parameters. Statistical analysis showed differences at comparing flavonoids vs. control and the overall higher effectiveness of the flavonoid naringenin. Observation of colonization was made by light and electron microscope confirming internal colonization of Andean blackberry roots by A. caulinodans. This is the first work demonstrating root colonization of R.glaucus by azorhizobia and therefore settling the basis for future investigations and scientific applications related to interaction with plant growth-promoting bacteria under the effect of flavonoids, along with possible implications of common benefit for non-legume crops in the northwest region of Colombia.  Key Words: Azorhizobium caulinodans ORS571, Andean blackberry, flavonoids, LacZ, lateral roots, naringenin.
Typology of Tri Ning Danu Tourist in Bedugul Tourism Area, Bali
Authors: Sunarta I Nyoman , Sukma Arida Ni Nyoman , Adikampana I Made , Karmini Ni Luh , Nugroho Saptono
Published: September 2017

The study aims to find the profile in the form of tourist's typology of the three lakes (Beratan, Buyan and Tamblingan) in Bedugul. Tourist's typology related to the characteristics of the tourism market in Bedugul.This study utilize the survey method to deploy a number of questionnaires. The questionnaires in the form of a structured list of questions to respondents in one time (cross-sectional). The questions posed related to the characteristics of the respondent. Respondents in this study are tourits who travel activities in the three lakes. Respondents were determined using non-probability sampling (purposive sampling). Intake of sample based on certain criteria. The criteria based on the judgment or a certain quota specific. Selection of respondents in this study is based on a particular consideration to the purpose of research that tourists visiting the three lakes. The number of samples taken as many as 200 tourists. The number of respondents that are larger than 100 makes it possible to do statistical analysis. The results showed tourist's typology based on the characteristics of tourism market varied in the three lakes. There is also a similarity pattern in each lake typology related tourists visiting that want to enjoy nature and culture based tourist attractions, first timer tourist, and day visitors, tourist spending levels are relatively low, under IDR 500.000.
Quasi-linear dependence of Coulomb forces on coupling strength parameter in the non-relativistic electronic Schrödinger equation and its consequences in Hund’s rule, Mølle -Plesset perturbation- , virial - , Hohenberg-Kohn - and Koopmans theorem
Authors: Kristyan Sandor
Published: September 2017

The extended non-relativistic electronic Hamiltonian, HÑ+ Hne+ aHee, is linear in coupling strength parameter (a), but its eigenvalues (interpreted as electronic energies) have only quasi-linear dependence on “a”. No detailed analysis has yet been published on the ratio or participation of electron-electron repulsion energy (Vee) in total electronic energy – apart from virial theorem and the highly detailed and well-known algorithm for Vee, which is calculated during the standard HF-SCF and post-HF-SCF routines. Using a particular modification of the SCF part in the Gaussian package we have analyzed the ground state solutions via the parameter “a”. Technically, this modification was essentially a modification of a single line in an SCF algorithm, wherein the operator rij-1 was overwritten as rij-1 ® arij-1, and used “a” as input. The most important finding beside that the repulsion energy Vee(a) is a quasi-linear function of “a”, is that the extended 1st Hohenberg-Kohn theorem (Y0(a=1) Û Hne Û Y0(a=0)) and its consequences in relation to “a”. The latter allows an algebraic transfer from the simpler solution of case a=0 (where the single Slater determinant is the accurate form) to the realistic wanted case a=1. Moreover, we have generalized the emblematic theorems in the title in relation to the coupling strength parameter.
O Regime Jurídico do Branqueamento de Capitais
Authors: Lopes Patrícia Teixeira
Published: September 2017

O presente trabalho tem como primacial objectivo contribuir, ainda que modestamente, para a alteração do Direito Positivo português que regula a prevenção e a repressão do branqueamento de capitais, por forma a adequá-lo aos mais recentes diplomas comunitários sobre a matéria. Não poderíamos faze-lo, de um ponto de vista de correcção metodológica, sem antes abordar, ainda que de forma necessariamente breve e genérica, como impõe a natureza do estudo apresentado, a génese do branqueamento de capitais e o regime jurídico que lhe é aplicável no momento actual. Procurando, de seguida, apreciar as principais peculiaridades e as modificações mais relevantes dos modelos de prevenção e repressão instituídos, a nível comunitário, pela Convenção do Conselho da Europa n° 198 e pela Directiva 2005/60/CE do Parlamento Europeu e do Conselho, de 26 de Outubro de 2005 e proceder à ponderação global das alterações fundamentais a operar na legislação nacional perspectivando a recepção dos mesmos pelo Direito interno. Sendo este o percurso traçado, almejamos, ao longo do mesmo, colocar especial enfoque na análise das referidas e inevitáveis alterações normativas em face dos princípios basilares do Direito Penal.
Os Contratos de Distribuição Comercial
Authors: Antunes José Engrácia
Published: September 2017

1 Generalidades 2 Agência 1. Noção / 2. Caracterização / 3. Regime Jurídico 3 Concessão Comercial 1. Noção / 2, Caracterização / 3. Regime Jurídico 4 Franquia 1. Noção / 2. Caracterização /3. Regime Jurídico 5 Mediação 1. Noção /2. Caracterização / 3. Regime Jurídico 6 Outros 1. Comissão / 2. Distribuição Selectiva / 3. Distribuição Autorizada
ENVIRONMENTAL LEARNING APPROACHES IN IMPROVING LEARNING OUTCOMES IN ACID-BASE SUBJECT
Authors: Sahputra Rachmat
Published: September 2017

Learning in the understanding of acid-base chemistry in schools needs to be improved so research to determine differences in learning outcomes between students taught using environmental approaches and methods lectures in class XI SMA on acid-base subject needs to be done. In this study, using a quasi-experimental method using a data collection tool achievement test essay form. The test statistic results of the post-test learning has been obtained Asymp value. Sig (2-tailed) 0,026 that showed the differences between students' learning outcomes with a control experimental class with effect size of 0.63 or much influence difference with the percentage 23.57% which indicated that the learning environment approach can improve learning outcomes of high school students.
Offering a ‘Menu’ of Software and Case Study Options for the Group Project for Students Enrolled in the Introductory AIS Course: An Experimental Application Study
Authors: Premuroso Ronald F. , Kirkham Tara
Published: September 2017

Instructors teaching the introductory accounting information systems (AIS) course generally include some type of group project to reinforce the principles emphasized in this course. One of the challenges facing AIS instructors is which type(s) of group project(s) potentially improve the students' overall course learning experience, while at the same time addressing future career student objectives. If the AIS instructor has a mix of students with such differing career goals when teaching the AIS course, it is important for the instructor to consider possibly offering a variety of project choices for the group project. We test offering a ‘menu’ of software and case study group project options reflective of several career choices students have after graduation. We also describe how the instructor can operationalize such a ‘menu’ approach effectively using a learning management system (LMS), a minimal level of grading assistance, and other factors. We then measure student satisfaction with this approach, as well as the impact on the instructor's teaching ratings of such an approach. Finally, we measure the impact of a ‘menu’ choice on students' performance on the comprehensive final examination in the course. This paper provides empirical evidence in support of a ‘menu’ approach for group projects in the AIS course, a ‘menu’ which can be altered to accommodate the career aspirations of students majoring in accounting in most programs across the nation.
Separating Cats from Dogs: A Case Designed to Enhance Students' Abilities to Identify Incompatible Duties and Employee Red Flags
Authors: Hong Paul A. , Fordham David R. , Hayes David C.
Published: September 2017

Developed by a graduate student and leveraging his experience with a family owned business, this case provides an interesting scenario addressing – and integrating – a number of factors relating to fraud, including incompatible duties, the fraud triangle, psychological factors, and “red flags”. Results from an under-graduate AIS course support the case's efficacy as a student assignment. Student performance on the case closely corresponded with other assessment of learning measures, supporting the use of the case for evaluation purposes. The case also increased student interest and motivation. Most importantly, use of the case resulted in measured enhancement of students' abilities to recognize problems in an accounting system. A spreadsheet was developed to increase the efficiency of grading the case.
Assessing Internal Control Over Cash Receipts at NADCo Communications: An Instructional Case
Authors: Bromley Robert
Published: September 2017

The audit of internal control over financial reporting required by the Sarbanes Oxley Act has radically changed the accounting profession. The evaluation and disclosure of the assessment of the internal control's effectiveness is now required by management and their auditors. This paper describes the use of an internal control assessment case, as well as web-based supporting materials that can enhance students' ability to analyse internal controls and improve their writing skills. The need for these skills has been well established by the American Institute of Certified Public Accountants (AICPA), the American Accounting Association (AAA) Albrecht and Sack (2000) and others in the accounting profession. These resources are presented below along with a section describing the learning objectives they were designed to achieve. The assessment of these materials is presented in a final section. The results were positive and provide accounting educators with resources that can improve students' ability to evaluate internal controls and communicate their findings.
Morphometric analysis of three normal facial types in mixed dentition using posteroanterior cephalometric radiographs: preliminary results
Authors: Bigliazzi Renato , Walverde Eliana Ayala , Oliveira Derly Tescaro Narciso de , Bertoz André Pinheiro de Magalhães , Faltin Junior Kurt
Published: September 2017

The aim of the present investigation was to evaluate the craniofacial features of subjects with normal occlusion with different vertical patterns in the mixed dentition using morphometric analysis (Thin-Plate Spline analysis - TPS) applied to posteroanterior (PA) films. The sample comprised 39 individuals (18 females and 21 males), all in mixed dentition, aged from 8.4 to 10 years with satisfactory occlusion and balanced profile and with no history of orthodontic or facial orthopedic treatment. The sample was divided into three groups (mesofacial, brachyfacial and dolichofacial) according to the facial types proposed by Ricketts (1989). The average craniofacial configurations of each study group were obtained by orthogonal superimposition of Procrustes, thereby eliminating size differences and allowing only shape differences between groups to be analyzed by viewing the TPS deformation grid. Significant differences were found among the three facial types but were more remarkable between mesofacials and dolichofacials than between mesofacials and brachyfacials. TPS morphometric analysis proved efficient for accurate visualization of transverse and vertical differences among facial types even before pubertal growth spurt. These differences cannot be easily detected by traditional posteroanterior cephalometry.
Acceptance of deafness in deaf adolescents: A repertory grid study
Authors: Ballantine Jacqueline
Published: September 2017

The study investigated the acceptance and definition of deafness adolescents. A repertory grid (RG) technique was administered to 27 moderately to profoundly impaired subjects identified with neither deaf nor hearing persons, thereby denying their own deafness. Subjects also described deaf individuals (DI's) negatively but maintained positive self-concepts and displayed inadequate definitions of themselves and deafness. These findings have distinct implications for the management of the DI, with regard both to assessment and therapy. Results further demonstrated that the RG technique is an effective means to investigate the psychology of deafness.
Fatigue Analysis of Steering Knuckle using Finite Element Simulation: Technical Note
Authors: Madhusudhanan S. , Rajendran I. , Raguganeshkumar B.
Published: September 2017

Steering knuckle is a prominent component of an automobile steering system. It is subjected cyclic loads from the suspension system during its service life. The Spheroid Graphite (SG) iron is the most commonly used material for manufacturing the steering knuckle. Fatigue behaviour is therefore a key consideration in its design and performance evaluation. Geometric modelling and stress analysis of such steering knuckle using finite element analysis software is carried out. Then the fatigue life of steering knuckle made from SG iron has been evaluated under the different load conditions and the results have been compared.
CFD Simulation of Fin-and-Tube Heat Exchanger with Louvered Fin Configuration: Technical Note
Authors: Sabari M. , Channankiah D. , Shivalingappa D.
Published: September 2017

Heat exchanger plays a major role in almost all mechanical industries. Enhancement of heat transfer surface plays major role in numerous applications such as in heat exchangers, refrigeration and air conditioning systems etc. This paper examines the fluid flow and heat exchange on the air side of a multi-row fin-and-tube heat exchanger. A brief comparison is given between fin-and-tube heat exchanger attributes with louvered fins in a wider range of operating conditions defined by inlet air velocities. The brief representation on the calculated data for the louvered heat exchanger shows better heat transfer characteristics with a slightly higher pressure drop. The CFD procedure is validated by comparing the numerical simulation results with different inlet air velocities. Best combination of higher heat transfer and minimum pressure drop are occurred in inlet air velocity of 2.5 m/s.
Single Motor Mechanical Power-Split Transmission for Hybrid Racing Cars
Authors: Ranjan R. , Srinath S. , Dhakar A. , Rajasai B. , Nagaraj S.
Published: September 2017

A hybrid vehicle derives its power from two or more distinct sources such as an internal combustion (IC) engine and an electric motor. Based on the mechanical architecture, Hybrid Electric Vehicles can be divided into three categories: parallel hybrids, series hybrids, and power-split hybrids. Parallel hybrids require frequent role reversal due to restrictions on motor power, whereas series hybrids lead to lower efficiency of the whole power train. The power-split hybrids combine the advantages of these two configurations by using one IC engine and two motors. The main objective of this paper is to design a transmission system for a hybrid racing car which is powered by an IC engine and a single electric motor which are arranged so as to represent a unique power-split system. This configuration reduces the need of one motor and allows seamless transition between engine-only with regeneration mode, motor only mode and parallel mode.
Clinical usefulness of serum free light chains measurement in patients with multiple myeloma: comparative analysis of two different tests
Authors: Kubicki Tadeusz , Dytfeld Dominik , Baszczuk Aleksandra , Wysocka Ewa , Komarnicki Mieczysław , Lewandowski Krzysztof
Published: September 2017

Introduction: There are two commercially available tests for measurement of serum free light chains (sFLC) in multiple myeloma (MM) patients – Freelite and N Latex FLC. The aim of this study was to perform an assessment and direct comparison of the usefulness of the methods in routine clinical practice.
Methods: 40 refractory/relapsed MM patients underwent routine disease activity assessment studies, along with sFLC analysis using both assays. Correlation and concordance between the tests and sensitivity of studied methods of sFLC assessment were established. Special attention was focused on sFLC results in patients finally evaluated after completing the treatment.
Results: A weak correlation for the measurement of both κ [Passing–Bablok slope (PB) = 0.7681] and λ chains [(PB) = 1.542] was found. Using Bland–Altman plots, a bias of 0.0467 (κ) and -0.2133 (λ) between the measurements was documented. The concordance coefficient equaled 0.87 for κ, 0.62 for λ and 0.52 for κ/λ ratio. Ten patients had an abnormal Freelite assay κ/λ ratio and normal N Latex FLC κ/λ ratio. Three of these patients had negative serum protein electrophoresis results and fulfilled diagnostic criteria of stringent complete remission (sCR) according to N Latex FLC (but not according to Freelite). When the κ/λ ratio obtained by both methods was compared to patients’ serum/urine protein electrophoresis and immunofixation results, sensitivity of Freelite and N Latex FLC was established to be 62.5% and 41%, respectively.
Conclusions: There was no strong correlation or concordance between the two assays, and the sensitivity in terms of sFLC detection was different. This may cause problems when diagnosis of sCR is considered.
Analiza internetowych ofert pracy oraz poszukiwanych kwalifikacji w hotelarstwie na przykładzie województwa zachodniopomorskiego
Authors: Sidorkiewicz Marta , Tokarz-Kocik Anna
Published: September 2017

Cel. Celem pracy jest zidentyfikowanie potrzeb kadrowych hotelarzy z województwa zachodniopomorskiego. W niniejszym opracowaniu potrzeby kadrowe rozumiane są jako rodzaje stanowisk pracy wymagających obsadzenia oraz najczęściej poszukiwane przez hotelarzy cechy potencjalnych pracowników. Metoda. Metodą realizacji celu opracowania jest prezentacja studium przypadku w postaci analizy jakościowej rekrutacji zewnętrznej – na podstawie studiowania ogłoszeń o pracę hotelarzy szukających pracowników do podmiotów oferujących usługi zakwaterowania i wyżywienia funkcjonujących na terenie województwa zachodniopomorskiego. W badaniach przeanalizowano oferty pracy opublikowane w okresie 20 maja – 20 lipca 2016 roku na łamach 18 portali internetowych. Wyniki. W województwie zachodniopomorskim najczęściej poszukuje się pracowników na stanowisko recepcjonisty oraz kelnera. Największym atutem kandydatów do pracy w hotelarstwie z województwie zachodniopomorskim jest doświadczenie w branży i znajomość języków obcych. Ograniczenia badań i wnioskowania. Ze względu na fakt, iż przedstawione wyniki badań dotyczą tylko jednego województwa oraz na zróżnicowanie bazy noclegowej w każdym z województw wyników badań nie można uogólniać na całą populację. Implikacje praktyczne. Wnioski z przeprowadzonych badań mogą być użyteczne dla instytucji edukacyjnych na poziomie ponadgimnazjalnym oraz wyższym (kwestia dostosowania programów kształcenia do potrzeb przyszłych pracodawców absolwentów niniejszych instytucji edukacyjnych) oraz potencjalnych kandydatów do pracy w hotelarstwie (kwestia uzupełnienia kompetencji zawodowych oczekiwanych przez potencjalnych pracodawców). Oryginalność pracy. Niniejsze opracowanie jest pierwszą próbą identyfikacji potrzeb pracodawców w hotelarstwie, która dotyczy obiektów zlokalizowanych w województwie zachodniopomorskim. Rodzaj pracy. Artykuł prezentuje wyniki badań empirycznych.
An accidental datahound: Transitioning skills to experience and application
Authors: Black Douglas
Published: September 2017

I didn’t set out to become a data-driven librarian. The concept was still new when I was in library school, and smitten as I was with the human element of information structures and information seeking, the idea seemed detached, focused on mere numbers divorced from the daily face-to-face reality of a reference librarian.Well.
Internet Reviews
Authors: Roberts Joni R. , Drost Carol A.
Published: September 2017

American Vernacular Music ManuscriptsNational Historical Geographic Information System (NHGIS)RefWorld
A Novel Technique to Determine Foot Contribution to Limb-Length Discrepancy
Authors: Lane George
Published: September 2017

Evaluation for limb-length discrepancy is an important part of the biomechanical work-up in the podiatric musculoskeletal exam. By understanding the foot's contribution to such a discrepancy, the podiatric clinician will have better insight regarding treatment strategy. This technique will provide the clinician with a simple method to gain such insight.
Extreme Monsoon Rainfall Signatures Preserved in the Invasive Terrestrial Gastropod Lissachatina fulica
Authors: Ghosh Prosenjit , Rangarajan Ravi , Thirumalai Kaustubh , Naggs Fred
Published: September 2017

Indian summer monsoon (ISM) rainfall lasts for a period of 4 months with large variations recorded in terms of rainfall intensity during its period between June and September. Proxy reconstructions of past ISM rainfall variability are required due to the paucity of long instrumental records. However, reconstructing subseasonal rainfall is extremely difficult using conventional hydroclimate proxies due to inadequate sample resolution. Here, we demonstrate the utility of the stable oxygen isotope composition of gastropod shells in reconstructing past rainfall on subseasonal timescales. We present a comparative isotopic study on present day rainwater and stable isotope ratios of precipitate found in the incremental growth bands of giant African land snail Lissachatina fulica (Bowdich) from modern day (2009) and in the historical past (1918). Isotopic signatures present in the growth bands allowed for the identification of ISM rainfall variability in terms of its active and dry spells in the modern as well as past gastropod record. Our results demonstrate the utility of gastropod growth band stable isotope ratios in semiquantitative reconstructions of seasonal rainfall patterns. High resolution climate records extracted from gastropod growth band stable isotopes (museum and archived specimens) can expand the scope for understanding past subseasonal‐to‐seasonal climate variability.
Using Analytics to Nudge Student Responsibility for Learning
Authors: Fritz John
Published: September 2017

To scale student success, institutions may want to consider treating students more as partners, not just as customers or intervention recipients. One way to do so is sharing behavioral and academic feedback data that helps nudge students into taking responsibility for learning. The following chapter is drawn from the author's dissertation work (Fritz, 2016).
Ocular presentation of myasthenia gravis: A natural history cohort
Authors: Kamarajah Sivesh K. , Sadalage Girija , Palmer Jonathan , Carley Helena , Maddison Paul , Sivaguru Arulmaran
Published: September 2017

Introduction

There are limited data on the natural history of untreated myasthenia gravis (MG) with ocular presentation.

Methods

We analyzed 93 patients from symptom onset who presented to the Birmingham Midlands Eye Centre (BMEC) between January 2004 and July 2015. We used multiple stepwise logistic regression to identify predictive factors of generalization and Kaplan–Meier analysis on time to generalization.

Results

Forty‐six percent of patients developed generalized symptoms during the study period. Median time to generalization was 7 months. Time to generalization was earlier in patients seropositive for acetylcholine receptor (AChR) antibody (median 5 months vs. 21 months, P < 0.0001) and bilateral ptosis at onset (P = 0.015). Multivariate analysis identified AChR seropositivity [hazard ratio (HR) 5.03; 95% confidence interval (CI) 1.48–17.14; P = 0.001] and disease onset < 50 years (HR 3.58; 95% CI 1.18–10.90; P = 0.035) as risk factors for generalization.

Discussion

As patients were steroid‐naive before generalization, our cohort approximated the natural history of the condition. Muscle Nerve 57: 622–627, 2018
Characterization of APOE and TOMM40 allele frequencies in the Japanese population
Authors: Nishimura Akira , Nonomura Hidenori , Tanaka Shingo , Yoshida Michihiro , Maruyama Yuka , Aritomi Yutaka , Saunders Ann M. , Burns Daniel K. , Lutz Michael W. , Runyan Grant , Lai Eric , Budur Kumar , Roses Allen D.
Published: September 2017

Introduction

Dementia is one of the major health threats to our aging society, and Alzheimer's disease (AD) is the leading cause. In Japan, ∼15% of the elderly population has dementia. The apolipoprotein E (APOE) genotype and a polymorphism (rs10524523) in the translocase of outer mitochondrial membrane 40 (TOMM40) gene have been associated with the age of onset of AD. However, differences in allele frequencies of these markers in different ethnic populations are not well known.

Methods

Whole blood samples were collected from 300 Japanese subjects, and genomic DNA was extracted to determine APOE alleles and TOMM40 rs10524523 genotypes.

Results

Our results indicated that the APOE ε3–TOMM40′523 short haplotype is less frequent in Japanese subjects than in Caucasians, whereas the APOE ε3–TOMM40′523 long and APOE ε3–TOMM40′523 very long haplotypes are more frequent in Japanese subjects than in Caucasians. We also showed that the APOE ε4–TOMM40′523 short haplotype, which was noted to be frequently observed in African Americans, was also found in the Japanese population, although it is extremely rare in the Caucasian population.

Discussion

A biomarker risk assignment algorithm, using a combination of APOE, TOMM40′523 genotype, and age, has been developed to assign near‐term risk for developing the onset of mild cognitive impairment due to AD and is being used as an enrichment tool in an ongoing delay‐of‐onset clinical trial. Understanding the characterization of APOE and TOMM40 allele frequencies in the Japanese population is the first step in developing a risk algorithm for AD research and clinical applications for AD prevention in Japan.
Mothers’ self-reported grocery shopping behaviours with their 2- to 7-year-old children: relationship between feeding practices and mothers’ willingness to purchase child-requested nutrient-poor, marketed foods, and fruits and vegetables
Authors: Lively Kathryn , Babawale Oluborode , Thompson David M , Morris Amanda S , Harris Jennifer L , Sisson Susan B , Cheney Marshall K , Lora Karina R
Published: September 2017

Objective

To assess relationships between mothers’ feeding practices (food as a reward, food for emotion regulation, modelling of healthy eating) and mothers’ willingness to purchase child-marketed foods and fruits/vegetables (F&V) requested by their children during grocery co-shopping.

Design

Cross-sectional. Mothers completed an online survey that included questions about feeding practices and willingness (i.e. intentions) to purchase child-requested foods during grocery co-shopping. Feeding practices scores were dichotomized at the median. Foods were grouped as nutrient-poor or nutrient-dense (F&V) based on national nutrition guidelines. Regression models compared mothers with above-the-median v. at-or-below-the-median feeding practices scores on their willingness to purchase child-requested food groupings, adjusting for demographic covariates.

Setting

Participants completed an online survey generated at a public university in the USA.

Subjects

Mothers (n 318) of 2- to 7-year-old children.

Results

Mothers who scored above-the-median on using food as a reward were more willing to purchase nutrient-poor foods (β=0·60, P<0·0001), mothers who scored above-the-median on use of food for emotion regulation were more willing to purchase nutrient-poor foods (β=0·29, P<0·0031) and mothers who scored above-the-median on modelling of healthy eating were more willing to purchase nutrient-dense foods (β=0·22, P<0·001) than were mothers with at-or-below-the-median scores, adjusting for demographic covariates.

Conclusions

Mothers who reported using food to control children’s behaviour were more willing to purchase child-requested, nutrient-poor foods. Parental feeding practices may facilitate or limit children’s foods requested in grocery stores. Parent–child food consumer behaviours should be investigated as a route that may contribute to children’s eating patterns.
Angst. Panik. Hausarzt.
Authors: Hofer-Moser Otto
Published: September 2017

Der vorliegende Beitrag thematisiert den hilfreichen ärztlichen Umgang mit Angst- und Panikzuständen unterschiedlicher Intensität, mit denen PatientInnen in Bezug auf mögliche bzw. tatsächliche Erkrankungen reagieren. Der erste Teil vermittelte ein Verständnis evolutionsbiologischer und neurobiologischer Aspekte dieser Ängste, konzipiert als Furcht-Kognitions-System, Panik-Bindungs-System und basale Emotionssysteme. Dieses Verständnis vermag den konkreten klinischen Umgang mit diesen Ängsten zu erleichtern, indem es bereits bewährte klinische Interventionsstrategien für diese Situationen bestä- tigt und darüber hinaus hilft, diese Strategien differenzierter und überzeugter einzusetzen. Die konkreten Konsequenzen für den Praxisalltag werden in diesem zweiten Teil des Beitrages näher ausgeführt.
Behandlungskosten nach Knieprothesen-OP – Ein Vergleich zwischen der ambulanten und stationären
Rehabilitationsbehandlung
Authors: Bretzke Pascal , Potempa Christoph , Sauer Volker , Egermann Martin , Engels Stephan
Published: September 2017

Ziel Die postoperative Behandlung und frühzeitige Mobilisierung nach der Implantation eines künstlichen Gelenkersatzes ist für den
Heilungsprozess von essenzieller Bedeutung. Die vorliegende Arbeit evaluiert die Kosteneffektivität von zwei therapeutischen Optionen für
Patienten nach Knie- Endoprothesenimplantation.

Methodik Im Rahmen einer Modellrechnung basierend auf einer in Deutschland durchgeführten klinischen Studie wurden mittels
Entscheidungsbaum-Analysen die Effektivität und die Kostenfaktoren der Therapieoptionen „ambulante Rehabilitation“ und „stationäre
Rehabilitation“ verglichen. Die Effektparameter wurden der deutschen Studie von Sauer und Egermann entnommen, die Kostenfaktoren basieren
auf einer Literaturrecherche. Das gesundheitsökonomische Modell ist eine Kosten-Effektivitäts-Analyse für den Rehabilitationszeitraum von
drei Wochen. Die Kosten-Effektivität der Behandlungsalternativen wurde zu drei Beobachtungszeitpunkten (postoperativ nach 6, 12 und 52
Wochen) berechnet. Zur Überprüfung der Robustheit der Ergebnisse wurden Sensitivitätsanalysen durchgeführt.

Ergebnis Nach dreiwöchiger Rehabilitationsbehandlung fallen Kosten in Höhe von 2845,50 € für die stationäre und 1565,25 € (bzw. bei
maximalem Schienenpreis 1625,25 €) für die ambulante Therapie an. Zum ersten postoperativen Untersuchungszeitpunkt (6 Wochen postoperativ)
wurden unter Betrachtung des Knee Society Scores (KSS) effektivitäts-adjustierte Kosten in Höhe von 17,28 € (17,94 €) (Verumgruppe) und
35,66 € (Kontrollgruppe) generiert. Bei Betrachtung des Bewegungsumfanges in Flexion entstehen effektivitäts-adjustierte Kosten von 13,69 €
(14,22 €) (Verumgruppe) und 28,26 € (Kontrollgruppe) und unter Berücksichtigung des Oxford Scores wurden effektivitäts-adjustierte Kosten
von 41,96 € (43,57 €) (Verumgruppe) und 91,79 € (Kontrollgruppe) generiert. Die Ergebnisse blieben robust zu allen postoperativen
Untersuchungszeitpunkten und lagen signifikant über denen der Kontrollgruppe.

Diskussion und Schlussfolgerung Die Berechnung von effektivitäts-adjustierten Kosten zeigte einen Vorteil für die ambulante Behandlung
mit Physiotherapie und CPM-Motorschiene gegenüber einer stationären Behandlung gemäß Reha Standard der Deutschen Rentenversicherung.
Zusammenfassend kann aufgeführt werden, dass eine zielgerichtete Nutzung von CPM-Motorschienen dazu beitragen kann, die Versorgungsqualität,
aber auch die Patientenzufriedenheit und -Sicherheit langfristig und nachhaltig zu erhöhen.
Instrumente zur Messung der gesundheitsbezogenen Lebensqualität bei Kindern und Jugendlichen mit
chronisch-entzündlichen Darmerkrankungen – Systematisches Review und qualitative Analyse
Authors: Räcker Eva , Kreimeier Simone , Wolfgang Greiner
Published: September 2017

Zielsetzung Da die Erstmanifestation von chronisch-entzündlichen Darmerkrankungen (CED) nicht selten im Kindes- und Jugendalter liegt
und die Erkrankung das gesamte Lebensumfeld der Patienten beeinflusst, ist die Erfassung der gesundheitsbezogenen Lebensqualität (HRQoL) bei
Kindern und Jugendlichen mit CED von besonderer Relevanz. Ziel dieser Arbeit war es zu untersuchen, welche Instrumente bislang zur Messung
der selbstberichteten HRQoL bei der Zielgruppe verwendet werden sowie die beiden Messinstrumente EQ-5D-Youth (EQ-5D-Y) und IMPACT-III auf
ihre methodische Adäquatheit hin zu überprüfen.

Methode Zunächst wurden mittels systematischer Literaturrecherche (Februar 2016) die seit 2010 publizierten, relevanten Studien
bezogen auf die Fragestellung identifiziert und anschließend gesichtet. Bei der Prüfung der Messinstrumente EQ-5D-Y und IMPACT-III kamen
qualitätsbewertende Kriterien (z. B. Validität, Akzeptanz), die spezifisch für patientenberichtete Outcomes entwickelt wurden, sowie
leitfadengestützte Experteninterviews mit zwei Kindergastroenterologen zum Einsatz, um Stärken und Schwächen aus praktischer Perspektive zu
beleuchten.

Ergebnisse Insgesamt wurden 18 Studien in die systematische Übersichtsarbeit eingeschlossen. Dabei wurden verschiedene generische
Instrumente (KINDLR, KIDSCREEN-10, KIDSCREEN-27, PedsQLTM 4.0, 15D/16D/17D, CHQ-CF87 und EQ-5D) zur Messung der
selbstberichteten HRQoL von Kindern und Jugendlichen mit CED identifiziert, aber nur zwei krankheitsspezifische Instrumente (IMPACT-III,
SHS). Die detaillierte Betrachtung des EQ-5D-Y und des IMPACT-III ergab sowohl basierend auf den Qualitätskriterien als auch unter Einbezug
der Expertensicht, dass beide Instrumente grundsätzlich zur Erfassung der HRQoL von jungen CED-Patienten geeignet sind, allerdings jeweils
spezifische Optimierungspotenziale aufweisen.

Schlussfolgerungen Obwohl der EQ-5D-Y bisher nicht bei Kindern und Jugendlichen mit CED angewendet wurde, liegen erste Hinweise vor,
dass das Instrument zur Erfassung der HRQoL bei der Zielgruppe geeignet ist. Der IMPACT-III als krankheitsspezifisches Instrument ist
offenbar besonders geeignet zur Messung der HRQoL der Zielgruppe, was sich auch durch den fast standardmäßigen Einsatz zeigt. Dennoch weist
er – insbesondere durch seine Länge – eine Schwäche auf und seine Eignung sollte, vor allem im Vergleich zu dem neuen krankheitsspezifischen
Instrument Short Health Scale (SHS), genauer untersucht werden.
Advances in gene therapy for Wolfram syndrome
Authors: Hamel C. , Jagodzinska J. , Bonner‐Wersinger D. , Koks S. , Seveno M. , Delettre C.
Published: September 2017

The Wolfram Syndrome (WS) is an early onset genetic disease (1/200 000) featuring diabetes mellitus and progressive optic neuropathy ensuing mutations in the WFS1 gene. To date, there is no treatment to stop the progression of the disease. We have characterized the visual impairment of 2 mutants animal models for WFS1 (Wfs1exon8‐/‐ and Wfs1E864K) and shown that these 2 models developed an optic atrophy. We started for 1 year intravitreous micro injections of therapeutic vector AAV2‐CMV‐WFS1 on 1 month‐old Wfs1exon8‐/‐. Our results showed that mice injected exhibited a stabilization of their visual acuity at 3 and 6 months post‐injection, and a decrease of optic disc pallor and optic nerve damage. These promising results demonstrate the validity of the pre‐clinical approach to treat Wolfram Syndrome by gene therapy and encourage further studies under a treatment for the Wolfram Syndrome patients.