bluuebunny/crossref_metadata_2025 huggingface dataset:
Los umbrales del humanismo. Las polaridades de la cultura y sus relatos
Authors: Castellanos S.J. Luis Alfonso
Published: August 2023

El artículo “Los umbrales del humanismo. Las polaridades de la cultura y sus relatos” pretende realizar una introspección del humanismo como un proyecto narrativo y como una configuración afectiva que requiere de prácticas y artefactos culturales para conformar sujetos y sociedades.

Desde una mirada transdisciplinar y desde variadas perspectivas se problematiza la noción de humanismo como una configuración afectiva que se teje desde dos experiencias fundamentales: lo sublime y lo abyecto. Extremos que en sus manifestaciones se hacen los ejes de elaboración de cualquier sentido de “lo humano” y que sustentan los diversos relatos y artefactos que en la cultura de Occidente se han identificado con el humanismo. Narrativas humanísticas que además se consolidan en variados productos estéticos y que en sus diversas propuestas desean ser sapienciales. Sabiduría práctica más que teorías o elaboraciones éticas o filosóficas; presupuestos primeros de cualquier grupo humano que en su función de base establecen modos de proceder individuales y prácticas sociales.
Governing Equation Identification of Nonlinear Single Degree-of-Freedom Oscillators With Coulomb Friction Using Explicit Stick and Slip Temporal Constraints
Authors: Mahajan Saurabh , Cicirello Alice
Published: August 2023

The friction force at joints of engineering structures is usually unknown and not directly identifiable. This contribution explores a procedure for obtaining the governing equation of motion and correctly identifying the unknown Coulomb friction force of a mass-spring-dashpot system. In particular, a single degree-of-freedom system is investigated both numerically and experimentally. The proposed procedure extends the state-of-the-art data-driven sparse identification of nonlinear dynamics (SINDy) algorithm by developing a methodology that explicitly imposes constraints encoding knowledge of the nonsmooth dynamics experienced during stick-slip phenomena. The proposed algorithm consists of three steps: (i) data segregation of mass-motion from mass-sticking during stick-slip response; (ii) application of SINDy on the mass-motion dataset to obtain the functional form of the governing equation; and (iii) applying sticking and slipping conditions to identify the unknown system parameters. It is shown that the proposed approach yields an improved estimate of the uncertain system parameters such as stiffness, viscous damping, and magnitude of friction force (all mass normalized) for various signal-to-noise ratios compared to SINDy.
REVIEWS OF ACOUSTICAL PATENTS
Authors: Fulop Sean A.
Published: August 2023

The purpose of these acoustical patent reviews is to provide enough information for a Journal reader to decide whether to seek more information from the patent itself. Any opinions expressed here are those of the reviewers as individuals and are not legal opinions. Patents are available via the internet at the USPTO website.
Acoustic ducting by shelf water streamers at the New England shelfbreak
Authors: Johnson Jennifer J. , Lin Ying-Tsong , Newhall Arthur E. , Gawarkiewicz Glen G. , Knobles David P. , Chaytor Jason D. , Hodgkiss William S.
Published: August 2023

Greater sound speed variability has been observed at the New England shelfbreak due to a greater influence from the Gulf Stream with increased meander amplitudes and frequency of Warm Core Ring (WCR) generation. Consequently, underwater sound propagation in the area also becomes more variable. This paper presents field observations of an acoustic near-surface ducting condition induced by shelf water streamers that are related to WCRs. The field observations also reveal the subsequent disappearance of the streamer duct due to the passage of a WCR filament. These two water column conditions are investigated with sound propagation measurements and numerical simulations.
Circle of Willis integrity in acute middle cerebral artery occlusion: does the posterior communicating artery matter?
Authors: Sadeh-Gonik Udi , Budylev Anatoly , Krivitzky David , Molad Jeremy , Halevi Hen , Jonas-Kimchi Tali , Yashar Hila , Ben Assayag Einor , Seyman Estelle
Published: August 2023

Background

Collateral circulation is an important determinant of outcome in people with acute ischemic stroke due to large vessel occlusion (LVO).

Objective

To explore the impact of the circle of Willis (CW) anatomical characteristics ipsilateral to the occlusion site, particularly the posterior communicating artery (PComA) and the A1-portion of the anterior cerebral artery (A1-ACA), on stroke outcomes in a cohort of patients with LVO and middle cerebral artery (MCA) occlusion, undergoing endovascular thrombectomy (EVT).

Methods

This is a retrospective cohort study performed in a comprehensive tertiary stroke center. The study population consisted of consecutive patients with LVO with proximal MCA occlusion (M1) between June 2016 and April 2021, undergoing EVT. Demographic, clinical, and imaging information was extracted from patient files. Patency and diameters of ipsilateral A1-ACA and PComA were manually measured on admission CT angiography images in the core laboratory.

Results

One hundred and five patients with LVO comprised the study cohort, mean age 72.3 years, 43.8% were male, mean National Institutes of Health Stroke Scale score at admission 15.2. The cohort was grouped according to CW vessel characteristics. On univariate analysis, a well-developed PComA was associated with lower rates of hemorrhagic transformation (1.8% vs 14.3%, P=0.01) and a trend towards lower mortality rates (8.9% vs 20.4%, P=0.08).On multivariable regression analysis a well-developed PComA emerged as an independent predictor for survival (aOR=0.09, 95% CI 0.01 to 0.4 for survival at discharge, P=0.009, aOR=0.22, 95% CI 0.05 to 0.8 for survival at 90 days, P=0.02).

Conclusions

In a cohort of patients with LVO due to M1 occlusion undergoing EVT, a well-developed PComA was associated with significantly lower hemorrhagic transformation rates, a trend towards better functional outcomes, and independently predicted survival. Larger studies are needed to understand the differential effect of CW collateral conduits on stroke outcome and evaluate the practicality of incorporating such factors in the clinical decision-making process prior to EVT.
MR microscopy to assess clot composition following mechanical thrombectomy predicts recanalization and clinical outcome
Authors: Karimian-Jazi Kianush , Vollherbst Dominik F , Schwarz Daniel , Fischer Manuel , Schregel Katharina , Bauer Gregor , Kocharyan Anna , Sturm Volker , Neuberger Ulf , Jesser Jessica , Herweh Christian , Ulfert Christian , Hilgenfeld Tim , Seker Fatih , Preisner Fabian , Schmitt Niclas , Charlet Tobias , Hamelmann Stefan , Sahm Felix , Heiland Sabine , Wick Wolfgang , Ringleb Peter A , Schirmer Lucas , Bendszus Martin , Möhlenbruch Markus A , Breckwoldt Michael O
Published: August 2023

Background

Mechanical thrombectomy (MT) is the standard of care for patients with a stroke and large vessel occlusion. Clot composition is not routinely assessed in clinical practice as no specific diagnostic value is attributed to it, and MT is performed in a standardized ‘non-personalized’ approach. Whether different clot compositions are associated with intrinsic likelihoods of recanalization success or treatment outcome is unknown.

Methods

We performed a prospective, non-randomized, single-center study and analyzed the clot composition in 60 consecutive patients with ischemic stroke undergoing MT. Clots were assessed by ex vivo multiparametric MRI at 9.4 T (MR microscopy), cone beam CT, and histopathology. Clot imaging was correlated with preinterventional CT and clinical data.

Results

MR microscopy showed red blood cell (RBC)-rich (21.7%), platelet-rich (white,38.3%) or mixed clots (40.0%) as distinct morphological entities, and MR microscopy had high accuracy of 95.4% to differentiate clots. Clot composition could be further stratified on preinterventional non-contrast head CT by quantification of the hyperdense artery sign. During MT, white clots required more passes to achieve final recanalization and were not amenable to contact aspiration compared with mixed and RBC-rich clots (maneuvers: 4.7 vs 3.1 and 1.2 passes, P<0.05 and P<0.001, respectively), whereas RBC-rich clots showed higher probability of first pass recanalization (76.9%) compared with white clots (17.4%). White clots were associated with poorer clinical outcome at discharge and 90 days after MT.

Conclusion

Our study introduces MR microscopy to show that the hyperdense artery sign or MR relaxometry could guide interventional strategy. This could enable a personalized treatment approach to improve outcome of patients undergoing MT.
Supplementary Data from Oxidative Phosphorylation Fueled by Fatty Acid Oxidation Sensitizes Leukemic Stem Cells to Cold
Authors: Griessinger Emmanuel , Pereira-Martins Diego , Nebout Marielle , Bosc Claudie , Saland Estelle , Boet Emiline , Sahal Ambrine , Chiche Johanna , Debayle Delphine , Fleuriot Lucile , Pruis Maurien , De Mas Véronique , Vergez François , Récher Christian , Huls Gerwin , Sarry Jean-Emmanuel , Schuringa Jan Jacob , Peyron Jean-François
Published: August 2023

Supplementary method, Figures and references
Table S7 from Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer
Authors: Müller Nina , Lorenz Carina , Ostendorp Jenny , Heisel Felix S. , Friese Ulrich P. , Cartolano Maria , Plenker Dennis , Tumbrink Hannah , Heimsoeth Alena , Baedeker Philipp , Weiss Jonathan , Ortiz-Cuaran Sandra , Büttner Reinhard , Peifer Martin , Thomas Roman K. , Sos Martin L. , Berg Johannes , Brägelmann Johannes
Published: August 2023

Suppl. Table S7, differentially expressed genes
Figure S2 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Supplemental Figure 2
Supplementary File 6 from Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
Authors: Ludwig Michael P. , Galbraith Matthew D. , Eduthan Neetha Paul , Hill Amanda A. , Clay Michael R. , Tellez Cristiam Moreno , Wilky Breelyn A. , Elias Anthony , Espinosa Joaquin M. , Sullivan Kelly D.
Published: August 2023

Nutlin-3-carfilzomib-treated LPS transcriptome analyses.
Supplementary Figure 1 from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Figure 1
Figure S7 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Authors: Shu Xiaodong , Li Jianjie , Chan Un In , Su Sek Man , Shi Changxiang , Zhang Xin , An Tingting , Xu Jun , Mo Lihua , Liu Jianlin , Wang Yuqing , Li Xiaoling , Deng Min , Lei Josh Haipeng , Wang Chunfei , Tian Hao , Heng Sun , Shim Joong Sup , Zhang Xuanjun , Dai Yunlu , Yao Zhicheng , Kuang Xiaying , Lin Ying , Deng Chu-Xia , Xu Xiaoling
Published: August 2023

Original picture
Supplementary Fig. S2 from The mTOR Signaling Pathway Interacts with the ER Stress Response and the Unfolded Protein Response in Cancer
Authors: Mafi Sahar , Ahmadi Elham , Meehan Eileen , Chiari Conner , Mansoori Behzad , Sadeghi Hossein , Milani Sahar , Jafarinia Morteza , Taeb Shahram , Mafakheri Bashmagh Bayan , Mansoorian Seyed Mohammad Ali , Soltani-Zangbar Mohammad Sadegh , Wang Kepeng , Rostamzadeh Davoud
Published: August 2023

Supplementary Fig. S2. Endoplasmic reticulum stress and unfolded protein response in normal physiology and cancer
Tumor cells frequently encounter endogenous and exogenous stresses that influence protein folding in the ER, including hypoxia, inflammation, nutrient deprivation, altered glycolysis, DNA damage, genomic instability, oncogene activation, and proteasome dysfunction, can cause excessive accumulation of misfolded or unfolded proteins within the ER lumen, a condition termed "ER stress." As a response to prolonged ER stress conditions, the ER responds to the ER stress by activating intracellular signal transduction pathways, collectively referred to as the UPR, to restore-ER homeostasis (protective effect) or activate cell death (cytotoxic effect). The UPR signaling cascade comprises three parallel pathways that employ unique signal transduction mechanisms and are initiated by activating three conserved ER-stress sensors: IRE1, ATF6, and PERK. Furthermore, in mammals and under resting conditions, the critical ER-resident chaperone, GRP78/BiP, prevents the activation and blocks the downstream signaling of UPR by binding to the N-terminal side of stress sensor proteins, IRE-1, PERK, and ATF6 and maintains these sensors in an inactive state. When ER stress is triggered, and the ER luminal load of unfolded or misfolded proteins increases, the GRP78/BiP dissociates, activating IRE1, PERK, and ATF6 signaling cascades, leading to the activation of these UPR signaling pathways. Upon activation, the UPR can regulate many cellular events of tumor cells, including autophagy, ER biogenesis, cell survival, metastasis, angiogenesis, migration and invasion, chemoresistance, glycolysis, and proliferation.
ER, Endoplasmic reticulum; UPR, unfolded protein response; PREK, protein kinase R (PKR) like endoplasmic reticulum kinase; ATF, activating transcription factor; IRE1, inositol requiring enzyme 1; GRP78, 78-kDa glucose-regulated protein/immunoglobulin-binding protein; CHOP, C/EBP homologous protein; AMPK, AMP-activated protein kinase; XBP1, X-box binding protein 1; Dr5, death receptor 5; GADD34, growth arrest and DNA damage-inducible protein 34; ERO1α, ER oxidoreductin 1; GCN2, general control non-derepressible 2.
Supplementary Data from Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis
Authors: Ghosh Santanu , Yang Rachel , Duraki Darjan , Zhu Junyao , Kim Ji Eun , Jabeen Musarrat , Mao Chengjian , Dai Xinyi , Livezey Mara R. , Boudreau Matthew W. , Park Ben H. , Nelson Erik R. , Hergenrother Paul J. , Shapiro David J.
Published: August 2023

Supplementary Movie 1
The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung
Authors: Mathur Deepti , Liao Chen , Lin Wendy , La Ferlita Alessandro , Alaimo Salvatore , Taylor Samuel , Zhong Yi , Iacobuzio-Donahue Christine , Ferro Alfredo , Xavier Joao B.
Published: August 2023

Understanding the rewired metabolism underlying organ-specific metastasis in breast cancer could help identify strategies to improve the treatment and prevention of metastatic disease. Here, we used a systems biology approach to compare metabolic fluxes used by parental breast cancer cells and their brain- and lung-homing derivatives. Divergent lineages had distinct, heritable metabolic fluxes. Lung-homing cells maintained high glycolytic flux despite low levels of glycolytic intermediates, constitutively activating a pathway sink into lactate. This strong Warburg effect was associated with a high ratio of lactate dehydrogenase (LDH) to pyruvate dehydrogenase (PDH) expression, which correlated with lung metastasis in patients with breast cancer. Although feature classification models trained on clinical characteristics alone were unable to predict tropism, the LDH/PDH ratio was a significant predictor of metastasis to the lung but not to other organs, independent of other transcriptomic signatures. High lactate efflux was also a trait in lung-homing metastatic pancreatic cancer cells, suggesting that lactate production may be a convergent phenotype in lung metastasis. Together, these analyses highlight the essential role that metabolism plays in organ-specific cancer metastasis and identify a putative biomarker for predicting lung metastasis in patients with breast cancer.

Significance:

Lung-homing metastatic breast cancer cells express an elevated ratio of lactate dehydrogenase to pyruvate dehydrogenase, indicating that ratios of specific metabolic gene transcripts have potential as metabolic biomarkers for predicting organ-specific metastasis.
Androgen Receptor Variants Confer Castration Resistance in Prostate Cancer by Counteracting Antiandrogen-Induced Ferroptosis
Authors: Sun Rui , Yan Binyuan , Li Hao , Ding Donglin , Wang Liguo , Pang Jun , Ye Dingwei , Huang Haojie
Published: August 2023

Androgen receptor (AR) inhibition by androgen deprivation and/or antiandrogen administration is the mainstay therapy for advanced prostate cancer. However, most prostate cancers ultimately become resistant to these therapies, indicating the importance of identifying mechanisms driving resistance to improve patient outcomes. Here we demonstrated that acute treatment with the antiandrogen enzalutamide (ENZ) decreased glutathione (GSH) production, increased lipid peroxidation, and induced ferroptosis in prostate cancer cells. Consistently, meta-analysis of transcriptomic data linked the androgen-AR axis to metabolism-related biological processes, including lipid metabolism. The cystine transporter gene SLC7A11 was a key AR target, and full-length AR (AR-FL) transactivated SLC7A11 transcription by directly occupying the SLC7A11 promoter and putative enhancer regions. AR variants (AR-V) preferentially bound the SLC7A11 enhancer and upregulated SLC7A11 expression, thereby conferring resistance to ferroptosis induced by ENZ treatment. However, this effect was abolished following downregulation of AR-Vs using the dual CBP/p300 and BET inhibitor NEO2734. These findings reveal ferroptosis induction as an anticancer mechanism of antiandrogens and SLC7A11 as a direct target gene of AR-FL and AR-Vs. AR-V-mediated SLC7A11 expression represents a mechanism coupling ferroptosis resistance to prostate cancer progression.

Significance:

Upregulation of SLC7A11 can be induced by androgen receptor variants to inhibit antiandrogen-induced prostate cancer cell ferroptosis and to drive castration resistance in prostate cancer.
Supplementary Table S2 from Prediagnostic 25-Hydroxyvitamin D in Association with Cancer-specific and All-cause Mortality among Low-income, Non-Hispanic Black Americans with Colorectal Cancer
Authors: Lawler Thomas P. , Khankari Nikhil K. , Shu Xiao-Ou , Steinwandel Mark , Cai Qiuyin , Jurutka Peter W. , Zheng Wei , Warren Andersen Shaneda
Published: August 2023

Supplementary Table S2: Median [IQR] time between SCCS enrollment and cancer incidence, end of follow-up in 218 colorectal cancer patients
Supplementary Methods from Associations between Etiologic or Prognostic Tumor Tissue Markers and Neighborhood Contextual Factors in Male Health Professionals Diagnosed with Prostate Cancer
Authors: Iyer Hari S. , Kensler Kevin H. , Vaselkiv Jane B. , Stopsack Konrad H. , Roscoe Charlotte , Bandera Elisa V. , Qin Bo , Jang Thomas L. , Lotan Tamara L. , James Peter , Hart Jaime E. , Mucci Lorelei A. , Laden Francine , Rebbeck Timothy R.
Published: August 2023

inverse probability of censoring weights
Table 3 from Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium
Authors: Gersekowski Kate , Ibiebele Torukiri I , Doherty Jennifer A. , Harris Holly R. , Goodman Marc T. , Terry Kathryn L. , Wu Anna H. , Bandera Elisa V. , Qin Bo , Ong Jue-Sheng , Tyrer Jonathan P. , Dixon-Suen Suzanne C. , Modugno Francesmary , Risch Harvey A , Webb Penelope M.
Published: August 2023

Association between folate intake and risk of invasive epithelial ovarian cancer, by endometriosis status.
Supplementary Table 1 from Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium
Authors: Gersekowski Kate , Ibiebele Torukiri I , Doherty Jennifer A. , Harris Holly R. , Goodman Marc T. , Terry Kathryn L. , Wu Anna H. , Bandera Elisa V. , Qin Bo , Ong Jue-Sheng , Tyrer Jonathan P. , Dixon-Suen Suzanne C. , Modugno Francesmary , Risch Harvey A , Webb Penelope M.
Published: August 2023

Supplementary Table 1 shows the range of folate intake included in each tertile, by OCAC study site.
Supplementary Figure 3 from Folate Intake and Ovarian Cancer Risk among Women with Endometriosis: A Case–Control Study from the Ovarian Cancer Association Consortium
Authors: Gersekowski Kate , Ibiebele Torukiri I , Doherty Jennifer A. , Harris Holly R. , Goodman Marc T. , Terry Kathryn L. , Wu Anna H. , Bandera Elisa V. , Qin Bo , Ong Jue-Sheng , Tyrer Jonathan P. , Dixon-Suen Suzanne C. , Modugno Francesmary , Risch Harvey A , Webb Penelope M.
Published: August 2023

Supplementary Figure 3 shows scatter plots with the genetic association with folate on the x-axis and the genetic association with ovarian cancer on the y-axis, for (A) women with and (B) without endometriosis. The regression line for the inverse variance weighted Mendelian randomization method is shown.
Supplementary Table 9 from Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer
Authors: Wang Xiaoyan , Tian Ruiyi , Zong Xiaoyu , Jeon Myung Sik , Luo Jingqin , Colditz Graham A. , Wang Jean S. , Tsilidis Konstantinos K. , Ju Yo-El S. , Govindan Ramaswamy , Puri Varun , Cao Yin
Published: August 2023

Supplementary Table 9 shows the additive interaction between composite sleep score and genetic risk with EAC risk
Supplementary Table 3 from Sleep Behaviors, Genetic Predispositions, and Risk of Esophageal Cancer
Authors: Wang Xiaoyan , Tian Ruiyi , Zong Xiaoyu , Jeon Myung Sik , Luo Jingqin , Colditz Graham A. , Wang Jean S. , Tsilidis Konstantinos K. , Ju Yo-El S. , Govindan Ramaswamy , Puri Varun , Cao Yin
Published: August 2023

Supplementary Table 3 shows the sensitivity analyses for the association between sleep and EAC and ESCC by excluding cancer cases diagnosed within 2 years of enrollment
Supplementary Figure S1 from The Association of Neighborhood Characteristics and Frailty in Childhood Cancer Survivors: A Report from the St. Jude Lifetime Cohort Study
Authors: Schwartz Lindsay F. , Dhaduk Rikeenkumar , Howell Carrie R. , Brinkman Tara M. , Ehrhardt Matthew J. , Delaney Angela , Srivastava Deo Kumar , Lanctot Jennifer Q. , Armstrong Gregory T. , Robison Leslie L. , Hudson Melissa M. , Ness Kirsten K. , Henderson Tara O.
Published: August 2023

Supplementary Figure S1: Geographic location of study participants (N=3806). In this map, each red dot indicates the address of each participant recorded at intake and geocoded for this study.
Supplementary Table S1 from Integrative Single-Cell and Bulk Transcriptomes Analyses Identify Intrinsic HNSCC Subtypes with Distinct Prognoses and Therapeutic Vulnerabilities
Authors: Dai Yibin , Wang Ziyu , Xia Yingchao , Li Jin , Wu Yaping , Wang Yanling , Jiang Hongbing , Cheng Jie
Published: August 2023

Detailed proportions of cells in 5 scRNA-seq datasets
Supplementary Figure S4 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade
Authors: Hong Dong-Chun , Yang Jing , Sun Cong , Liu Yuan-Tao , Shen Lu-Jun , Xu Bu-Shu , Que Yi , Xia Xiaojun , Zhang Xing
Published: August 2023

The landscape of copy number variants and results for blood detection.༈A༉Top genes in copy number changes in RIS and SARC groups filtered by COSMIC gene list.༈B༉Top genes in copy number changes in RIFS and FS subtypes.༈C༉Top genes in copy number changes in RIOS and OS subtypes.(D and E༉Flow cytometry (D) and ELISA (E) results of immune cells and cytokines in peripheral blood from patients.
Supplementary Table S1 from Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer
Authors: Tolmeijer Sofie H. , Boerrigter Emmy , Sumiyoshi Takayuki , Kwan Edmond M. , Ng Sarah W.S. , Annala Matti , Donnellan Gráinne , Herberts Cameron , Benoist Guillemette E. , Hamberg Paul , Somford Diederik M. , van Oort Inge M. , Schalken Jack A. , Mehra Niven , van Erp Nielka P. , Wyatt Alexander W.
Published: August 2023

Representativeness of study participants
Supplementary Figure S9 from Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer
Authors: Tolmeijer Sofie H. , Boerrigter Emmy , Sumiyoshi Takayuki , Kwan Edmond M. , Ng Sarah W.S. , Annala Matti , Donnellan Gráinne , Herberts Cameron , Benoist Guillemette E. , Hamberg Paul , Somford Diederik M. , van Oort Inge M. , Schalken Jack A. , Mehra Niven , van Erp Nielka P. , Wyatt Alexander W.
Published: August 2023

Changes in PSA levels between baseline and 4 weeks on-treatment in the different ctDNA kinetics groups
Tables S1 and S2 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma
Authors: Horowitch Brooke , Lee Daniel Y. , Ding Min , Martinez-Morilla Sandra , Aung Thazin Nwe , Ouerghi Feriel , Wang Xueting , Wei Wei , Damsky William , Sznol Mario , Kluger Harriet , Rimm David L. , Ishizuka Jeffrey J.
Published: August 2023

S1: Baseline patient characteristics in TMA 376 vs TMA 469S2: Patients treated with Ipi/Nio vs anti-PD-1 alone
Figure S7 from Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma
Authors: Horowitch Brooke , Lee Daniel Y. , Ding Min , Martinez-Morilla Sandra , Aung Thazin Nwe , Ouerghi Feriel , Wang Xueting , Wei Wei , Damsky William , Sznol Mario , Kluger Harriet , Rimm David L. , Ishizuka Jeffrey J.
Published: August 2023

Supplemental Figure 7: pSTAT1Y701, CD3, and driver mutation status in tumors based on combined STAT1 and PD-L1 status.
Supplementary Fig. 4 from A Phase 1/2 Multicenter Randomized Trial of Local Ablation plus Toripalimab versus Toripalimab Alone for Previously Treated Unresectable Hepatocellular Carcinoma
Authors: Zhou Chunhui , Li Yan , Li Jiaping , Song Botian , Li Hanfeng , Liang Bin , Gu Shanzhi , Li Haiping , Chen Changyong , Li Sai , Peng Changli , Liu Fei , Xiao Juxiong , Long Xueying , Li Ping , Xiong Zhengping , Yi Xiaoping , Liao Weihua , Shi Liangrong
Published: August 2023

Supplementary Fig. 4 A. Progression-free survival by PD-L1 status. B. Overall survival by PD-L1 status. Dot marks indicate censored data.
Supplementary Fig. 1 from A Phase 1/2 Multicenter Randomized Trial of Local Ablation plus Toripalimab versus Toripalimab Alone for Previously Treated Unresectable Hepatocellular Carcinoma
Authors: Zhou Chunhui , Li Yan , Li Jiaping , Song Botian , Li Hanfeng , Liang Bin , Gu Shanzhi , Li Haiping , Chen Changyong , Li Sai , Peng Changli , Liu Fei , Xiao Juxiong , Long Xueying , Li Ping , Xiong Zhengping , Yi Xiaoping , Liao Weihua , Shi Liangrong
Published: August 2023

Supplementary Fig. 1 Forest plot of subgroup analysis for progression-free survival (A) and overall survival (B).
Supplementary Table S1: Common co-occurring alterations with tissue-agnostic targets in select tumor types from Tumor-Agnostic Precision Medicine from the AACR GENIE Database: Clinical Implications
Authors: Gouda Mohamed A. , Nelson Blessie E. , Buschhorn Lars , Wahida Adam , Subbiah Vivek
Published: August 2023

Genes most frequently mutated in cases with tissue-agnostic targets in the overall altered population and top 5 cancers with highest number of profiled samples in each alteration
Supplementary Fig. 3 from An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer
Authors: Chandarlapaty Sarat , Dickler Maura N. , Perez Fidalgo Jose Alejandro , Villanueva-Vázquez Rafael , Giltnane Jennifer , Gates Mary , Chang Ching-Wei , Cheeti Sravanthi , Fredrickson Jill , Wang Xiaojing , Collier Ann , Moore Heather M. , Metcalfe Ciara , Lauchle Jennifer , Humke Eric W. , Bardia Aditya
Published: August 2023

Supplementary Fig. S3. Clinical benefit does not correlate with ctDNA ESR1 mutant allele frequency (MAF) baseline levels or dynamics upon treatment, or with baseline ER and PR protein levels by IHC in tumor tissue.
Supplementary Tables 1 from Multicenter Randomized Double-Blind Phase III Trial of Donafenib in Progressive Radioactive Iodine-Refractory Differentiated Thyroid Cancer
Authors: Lin Yansong , Qin Shukui , Yang Hui , Shi Feng , Yang Aimin , Han Xingmin , Liu Bin , Li Zhiyong , Ji Qinghai , Tang Lijun , Deng Zhiyong , Ding Yong , Fu Wei , Xie Xianhe , Li Linfa , He Xiaohui , Lv Zhongwei , Ma Qingjie , Shen Zan , Guo Zhuming , Chen Zhendong , Cui Yali , Tan Jian , Gao Zairong , Jing Shanghua , Lu Keyi , Luo Xianyang , Zhang Yuan , Fang Yong , Li Zhendong , Cheng Yizhuang , Lei Shangtong , Luan Sha , Chen Guang , Wang Guihua , Wu Liqing , Liu Lingling
Published: August 2023

Supplementary Tables
Figure S1 from Immunogenomic Landscape of Neuroendocrine Prostate Cancer
Authors: Bhinder Bhavneet , Ferguson Alison , Sigouros Michael , Uppal Manik , Elsaeed Ahmed G. , Bareja Rohan , Alnajar Hussein , Eng Kenneth Wha , Conteduca Vincenza , Sboner Andrea , Mosquera Juan Miguel , Elemento Olivier , Beltran Himisha
Published: August 2023

Suppl Figure 1. Classification of prostate tumors based on T-cell immune status
Supplementary Figure S2 from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML
Authors: Letson Christopher T. , Balasis Maria E. , Newman Hannah , Binder Moritz , Vedder Alexis , Kinose Fumi , Ball Markus , Kruer Traci , Quintana Ariel , Lasho Terra L. , Finke Christy M. , Almada Luciana L. , Grants Jennifer M. , Zhang Guolin , Fernandez-Zapico Martin E. , Gaspar-Maia Alexandre , Lancet Jeffrey , Komrokji Rami , Haura Eric , Sallman David A. , Reuther Gary W. , Karsan Aly , Rix Uwe , Patnaik Mrinal M. , Padron Eric
Published: August 2023

Supplemental Figure 2 shows PIM1 levels over time, GSEA data demonstrating increased PIM expression and Western blot images of PIM isoforms in all other cell lines
Supplementary Data S1 from Targeting BET Proteins Downregulates miR-33a To Promote Synergy with PIM Inhibitors in CMML
Authors: Letson Christopher T. , Balasis Maria E. , Newman Hannah , Binder Moritz , Vedder Alexis , Kinose Fumi , Ball Markus , Kruer Traci , Quintana Ariel , Lasho Terra L. , Finke Christy M. , Almada Luciana L. , Grants Jennifer M. , Zhang Guolin , Fernandez-Zapico Martin E. , Gaspar-Maia Alexandre , Lancet Jeffrey , Komrokji Rami , Haura Eric , Sallman David A. , Reuther Gary W. , Karsan Aly , Rix Uwe , Patnaik Mrinal M. , Padron Eric
Published: August 2023

Raw data associated with miRNA Array performed for Supplemental Figure 4F
Data from A Metabolically Optimized, Noncytotoxic Low-Dose Weekly Decitabine/Venetoclax in MDS and AML
Authors: Levitz David , Saunthararajah Yogen , Fedorov Kateryna , Shapiro Lauren C. , Mantzaris Ioannis , Shastri Aditi , Kornblum Noah , Sica R. Alejandro , Shah Nishi , Konopleva Marina , Gritsman Kira , Braunschweig Ira , Cooper Dennis L. , Pradhan Kith , Verma Amit , Feldman Eric J. , Goldfinger Mendel
Published: August 2023

AbstractPurpose:
Venetoclax (VEN) added to the hypomethylating agents (HMA) decitabine or azacitidine is the new standard of care for elderly patients with acute myeloid leukemia (AML) and is being evaluated in myelodysplastic syndrome (MDS). Current dosing of HMA/VEN relies on leukemia suppression through cytotoxicity which also impacts normal hematopoiesis. A regimen using once-weekly low-dose decitabine (LDDec) has demonstrated activity in myeloid malignancies. To overcome the severe myelosuppression often seen with HMA/VEN, we evaluated a once-weekly dosing regimen of VEN and LDDec in elderly and/or frail patients who were felt less likely to tolerate severe myelosuppression.
Patients and Methods:
This is a retrospective, single-center analysis of patients with AML, MDS, or chronic myelomonocytic leukemia treated with a once-weekly LDDec/VEN regimen. We also compare this regimen with a cohort treated with standard dosing HMA/VEN.
Results:
In a retrospective cohort of 39 patients, the overall response rate for patients receiving LDDec/VEN for first-line AML and MDS was 88% and 64%, respectively. In patients with TP53 mutations, the composite complete response rate was 71% and the median overall survival was 10.7 months. When compared with 36 patients receiving standard dose HMA/VEN, the LDDec/VEN patients had a longer time on therapy (175 vs. 78 days; P = 0.014) and a trend toward a higher rate of transfusion independence (47% vs. 26%; P = 0.33). Neutropenic fever occurred in 31% of patients, with a median of one hospitalization at any point during treatment.
Conclusions:
This preliminary clinical experience, although retrospective, provides proof-of-activity of noncytotoxic DNA methyltransferase 1–targeting by allowing frequent, sustained drug exposure often not possible with standard HMA/VEN regimens.
Data from Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
Authors: Maron Steven B. , Chatila Walid , Walch Henry , Chou Joanne F. , Ceglia Nicholas , Ptashkin Ryan , Do Richard Kinh Gian , Paroder Viktoriya , Pandit-Taskar Neeta , Lewis Jason S. , Biachi De Castria Tiago , Sabwa Shalom , Socolow Fiona , Feder Lara , Thomas Jasmine , Schulze Isabell , Kim Kwanghee , Elzein Arijh , Bojilova Viktoria , Zatzman Matthew , Bhanot Umesh , Nagy Rebecca J. , Lee Jeeyun , Simmons Marc , Segal Michal , Ku Geoffrey Yuyat , Ilson David H. , Capanu Marinela , Hechtman Jaclyn F. , Merghoub Taha , Shah Sohrab , Schultz Nikolaus , Solit David B. , Janjigian Yelena Y.
Published: August 2023

AbstractPurpose:
We report updated clinical outcomes from a phase II study of pembrolizumab, trastuzumab, and chemotherapy (PTC) in metastatic esophagogastric cancer in conjunction with outcomes from an independent Memorial Sloan Kettering (MSK) cohort.
Experimental Design:
The significance of pretreatment 89Zr-trastuzumab PET, plasma circulating tumor DNA (ctDNA) dynamics, and tumor HER2 expression and whole exome sequencing was evaluated to identify prognostic biomarkers and mechanisms of resistance in patients treated on-protocol with PTC. Additional prognostic features were evaluated using a multivariable Cox regression model of trastuzumab-treated MSK patients (n = 226). Single-cell RNA sequencing (scRNA-seq) data from MSK and Samsung were evaluated for mechanisms of therapy resistance.
Results:
89Zr-trastuzumab PET, scRNA-seq, and serial ctDNA with CT imaging identified how pre-treatment intrapatient genomic heterogeneity contributes to inferior progression-free survival (PFS). We demonstrated that the presence of intensely avid lesions by 89Zr-trastuzumab PET declines in tumor-matched ctDNA by 3 weeks, and clearance of tumor-matched ctDNA by 9 weeks were minimally invasive biomarkers of durable PFS. Paired pre- and on-treatment scRNA-seq identified rapid clearance of HER2-expressing tumor clones with expansion of clones expressing a transcriptional resistance program, which was associated with MT1H, MT1E, MT2A, and MSMB expression. Among trastuzumab-treated patients at MSK, ERBB2 amplification was associated with improved PFS, while alterations in MYC and CDKN2A/B were associated with inferior PFS.
Conclusions:
These findings highlight the clinical relevance of identifying baseline intrapatient heterogeneity and serial ctDNA monitoring of HER2-positive esophagogastric cancer patients to identify early evidence of treatment resistance, which could guide proactive therapy escalation or deescalation.
Supplementary File 2 from Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
Authors: Ghosh Susmita , Fan Fan , Powell Reid T. , Roszik Jason , Park Yong Sung , Stephan Clifford , Sebastian Manu , Tan Lin , Sorokin Alexey V. , Lorenzi Philip L. , Kopetz Scott , Ellis Lee M. , Bhattacharya Rajat
Published: August 2023

HTS data using 3D CRC spheroids showing growth curves and heat maps to demonstrate efficacy of different compounds when combined with trametinib.
Supplementary Fig.S6 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers
Authors: Zhou Wei , Fang Peng , Yu Dongan , Ren Hongyuan , You Meng , Yin Long , Mei Fei , Zhu Huikai , Wang Zhenzhen , Xu Hui , Cao Yuxia , Sun Xiaowei , Xu Xiaohong , Bi Jianjun , Wang Jin , Ma Lanping , Wang Xin , Chen Lin , Zhang Yongliang , Cen Xiaowei , Zhu Xi , Lou Liguang , Liu Datao , Tan Xiaoding , Yang Jinliang , Meng Tao , Shen Jingkang
Published: August 2023

Binding affinity based on enzyme-linked immunosorbent assay.
Supplementary Fig.S5 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers
Authors: Zhou Wei , Fang Peng , Yu Dongan , Ren Hongyuan , You Meng , Yin Long , Mei Fei , Zhu Huikai , Wang Zhenzhen , Xu Hui , Cao Yuxia , Sun Xiaowei , Xu Xiaohong , Bi Jianjun , Wang Jin , Ma Lanping , Wang Xin , Chen Lin , Zhang Yongliang , Cen Xiaowei , Zhu Xi , Lou Liguang , Liu Datao , Tan Xiaoding , Yang Jinliang , Meng Tao , Shen Jingkang
Published: August 2023

Binding specificity based on enzyme-linked immunosorbent assay.
Figure S1 from A Comparative Study of Neuroendocrine Heterogeneity in Small Cell Lung Cancer and Neuroblastoma
Authors: Cai Ling , DeBerardinis Ralph J. , Xie Yang , Minna John D. , Xiao Guanghua
Published: August 2023

Intratumoral NE heterogeneity in SCLC patient tumors and intra-cell line NE heterogeneity in SCLC and NBL cell lines.
Supplementary Figure 2 from Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation
Authors: Qiao Rui , Wei Mengmeng , Chen Hui , Zhang Xianhong , Zhang Jie , Gao Liyang , Ma Haijun , Wang Yujiong , Li Le
Published: August 2023

S2. TAp73 enhances PPP via 6PGD
Voice Onset Time of Greek Stops Productions by Greek Children with Cochlear Implants and Normal Hearing
Authors: Koupka Georgia , Okalidou Areti , Nicolaidis Katerina , Constantinidis Jannis , Kyriafinis Georgios , Menexes George
Published: August 2023

Introduction: Research on voice onset time (VOT) production of stops in children with CI versus NH has reported conflicting results. Effects of age and place of articulation on VOT have not been examined for children with CI. The purpose of this study was to examine VOT production by Greek-speaking children with CI in comparison to NH controls, with a focus on the effects of age, type of stimuli, and place of articulation. Methods: Participants were 24 children with CI aged from 2;8 to 13;3 years and 24 age- and gender-matched children with NH. Words were elicited via a picture-naming task, and nonwords were elicited via a fast mapping procedure. Results: For voiced stops, children with CI showed longer VOT than children with NH, whereas VOT for voiceless stops was similar to that of NH peers. Also, in both voiced and voiceless stops, the VOT differed as a function of age and place of articulation across groups. Differences as a function of stimulus type were only noted for voiced stops across groups. Conclusions: For the voiced stop consonants, which demand more articulatory effort, VOT production in children with CI was longer than in children with NH. For the voiceless stop consonants, VOT production in children with CI is acquired at a young age.
Dificultades y vulnerabilidades de la niñez migrante durante la pandemia por covid-19
Authors: Cárdenas María Elvira , Grau-Rengifo María Olaya , Alamo Anich Nicolle , Bernales Silva Margarita , López Contreras Eleonora , Donoso Vargas Bárbara , Veas Flores Alicia , Grau-Rengifo María Florencia
Published: August 2023

(analítico)
Considerando la necesidad de escuchar a niños y niñas migrantes, examinamos desde su mirada las dificultades y vulnerabilidades a las que ellos, ellas y sus familias se enfrentaron durante las cuarentenas, en la pandemia por covid-19 en Chile; durante ellas mantuvieron clases a distancia, en línea o por guías de trabajo. Hicimos entrevistas semiestructuradas con guión temático —utilizando técnicas gráficas— a 37 niños y niñas migrantes de Latinoamérica, y realizamos análisis de contenido. Evidenciamos que las familias migrantes, des-de la mirada de los niños y niñas, se han visto expuestas a dificultades y preocupaciones (dada la distancia física entre familiares), vulnerabilidades económicas, falta de redes familiares y dificultades en la organización del trabajo productivo y reproductivo; en cada caso desde los puntos de vista objetivo y subjetivo.
Palabras clave:  Migración; niñez; familia; pandemia; Chile; vulnerabilidad.
Uma América Latina em constante (re)definição
Authors: Moreira Igor Lemos
Published: August 2023

A obra “DUTRA, Eliana Regina de Freitas; MYERS, Jorge. (Org.). Continente por Definir: As Ideias de América no século XX. Belo Horizonte: Editora da UFMG, 2022. 516p.”, a partir de um exercício de História Intelectual aliado à História dos Conceitos, apresenta uma perspectiva inovadora para a análise sobre as identidades americanas, latino-americanas, hispânicas ou ibero-americanas. Explorando, especialmente, a ideia de redes e as trajetórias de sujeitos fundamentais para a construção de representações sobre o continente, a coletânea apresenta uma América Latina que pode ser entendida enquanto Campo de representações e como Lugar de imaginários. Ao longo da presente resenha, exploramos as principais contribuições de cada texto, assim como analisamos as questões centrais e possíveis contribuições da obra. Como principal aspecto, se compreende que a obra é uma publicação singular e importante, tendo em vista que discute tema caro aos estudos sobre as Américas, mas constantemente naturalizado: as identidades e representações nacionais.
Nominal Case in Christian Arabic Translations of the Gospels (9th-15th Centuries CE)
Authors: Stokes Phillip W.
Published: August 2023

Middle Arabic is conventionally defined as existing on a spectrum between colloquial Arabic on the low end and Classical Arabic on the high end. Differences between Middle Arabic and Classical Arabic that are not attested in a modern dialect are typically treated, historically at least, as due to pseudo-correction. This is especially true of non-Classical manifestations of nominal case. In this paper, I tag all instances of alif al-tanwīn – which in Qurʾānic and Classical Arabic marks the accusative on triptotic nouns that do not end in tāʾ marbūṭa – from representative portions of the manuscripts, both vocalized and unvocalized, of 15 Christian translations of the gospels into Arabic dating from the 9th to 15th centuries CE. The data demonstrate, contrary to previous descriptions, that the majority of case inflection is written in line with Classical Arabic norms. Further, the syntactic contexts in which non-Classical case markings occur follow regular patterns, which recur with remarkable consistency across time and manuscript. Instead of originating in pseudo-corrections, I propose the differences from Classical Arabic originated in attempts by Christian scribes to represent a variety of Arabic in which a vowel merger before tanwīn resulting in a single morpheme erased the vocalic distinctions between case vowels. These syntactic contexts include nominative, genitive, and accusative ones. Since Christian Arabic differed from the varieties for which the Arabic script and subsequent vocalizations were developed to write, scribes originally varied in the degree to which they adhered to the writing conventions, with some closely adhering and others taking greater liberties in order to represent the underlying variety with greater nuance. Over time, this led to several scribal traditions for writing tanwīn in Christian manuscripts, each of which is attested among the vocalized manuscripts included in this study and discussed in detail.
“The baze is our workstation, we report here every day”—Understanding the Role of Youth Practices in Urban Subculture
Authors: Muhando Isaac
Published: August 2023

Contemporary globalisation and urbanisation continue to play a significant role in how the youths (re)create and (re)define urban spaces in Africa. Major cities across the continent are becoming active sites for social and cultural transformation. With the economic slowdown and increased rate of unemployment, youths are seeking ways to adapt to these realities while at the same time staying true to their urban identity. The present study uses participatory observation to examine two of the emerging youth practices in Nairobi, which are, the baze and gengetone music, to underscore how the youths in Nairobi Eastlands engage these practices both as sites for bolstering their urban identity and as alternative spaces for earning a livelihood. The study reveals that both the baze and gengetone music are available platforms which city youths use to construct their urban identities while dealing with local social challenges such as alcoholism, drug abuse and negative ethnicity, as well as harsh economic realities such as unemployment and a high cost of living. Further examination shows that discourse spaces created by these practices afford them a chance to participate in matters of national interest where they can contest and challenge social orders that are oppressive.
Il n’y a pas à dire, un marqueur discursif du refus de contestation
Authors: Ramos Sañudo Ana María
Published: August 2023

This work presents an analysis of the marker il n’y a pas à dire from different perspectives. First, we study its lexicographical treatment in nine dictionaries and its presence in our corpus of written examples of contemporary French. Then, we consider the morphosyntactic and semantic-pragmatic attributes that make it an epistemic marker of the indisputable. With il n’y a pas à dire speakers consider the enunciative content as something undeniable: by using this linguistic unit they protect themselves behind the knowledge that is supposed to be shared with the community they belong to, so a personal assertion can be presented as if it were something already accepted, to which there could be no objection. The commitment to the content modalised by il n’y a pas à dire is thus intensified, because the speakers, who are committed to what they are saying, want to be assertive in the eyes of their interlocutors in order to have this content admitted.
Approche sémantique et contrastive des connecteurs français en fait et italien infatti : la proximité morphologique révèle-t-elle une proximité sémantique?
Authors: Chériaa Najah
Published: August 2023

This article is focusing on the following question: to what extent the morphological proximity between the french linguistic connector en fait and the italian linguistic connector infatti reveals a semantic proximity? In the framework of a lexical analysis, the prepositions en and in, as well as fait and fatti, it is needed to verify that the possibility of use of a connector can be determined by various parameters combining the semantic, lexical and morphological aspects. It is also important to highlight that both the French and Italian connectors are not always used within similar contexts and that the semes in the nominal core and in the preposition persist more in en fait than in infatti.