bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing an Improved Parameter Estimation Method for the Segmented Taper Equation through Combination of Constrained Two-Dimensional Optimum Seeking and Least Square Regression
Authors: Pang Lifeng , Ma Yongpeng , Sharma Ram , Rice Shawn , Song Xinyu , Fu Liyong
Published: August 2016

The segmented taper equation has great flexibility and is widely applied in exiting taper systems. The unconstrained least square regression (ULSR) was generally used to estimate parameters in previous applications of the segmented taper equations. The joint point parameters estimated with ULSR may fall outside the feasible region, which leads to the results of the segmented taper equation being uncertain and meaningless. In this study, a combined method of constrained two-dimensional optimum seeking and least square regression (CTOS & LSR) was proposed as an improved method to estimate the parameters in the segmented taper equation. The CTOS & LSR was compared with ULSR for both individual tree-level equation and the population average-level equation using data from three tropical precious tree species (Castanopsis hystrix, Erythrophleum fordii, and Tectona grandis) in the southwest of China. The differences between CTOS & LSR and ULSR were found to be significant. The segmented taper equation estimated using CTOS & LSR resulted in not only increased prediction accuracy, but also guaranteed the parameter estimates in a more meaningful way. It is thus recommended that the combined method of constrained two-dimensional optimum seeking and least square regression should be a preferred choice for this application. The computation procedures required for this method is presented in the article.
Does REDD+ Ensure Sectoral Coordination and Stakeholder Participation? A Comparative Analysis of REDD+ National Governance Structures in Countries of Asia-Pacific Region
Authors: Fujisaki Taiji , Hyakumura Kimihiko , Scheyvens Henry , Cadman Tim
Published: August 2016

Reducing emissions from deforestation and forest degradation in developing countries (REDD+) requires harmonizing different policy sectors and interests that have impacts on forests. However, these elements have not been well-operationalized in environmental policy-making processes of most developing countries. Drawing on five cases—Cambodia, Indonesia, Lao PDR, Papua New Guinea, and Vietnam, this article aims to determine whether emerging governance arrangements help REDD+ development by delivering participatory mechanisms for policy coordination. Building upon literature on environmental governance and stakeholder participation, the article examines national governance structures for REDD+ and identifies who participates where, and what decision-making powers they have. Despite structural differences between the countries, our analysis illustrates that REDD+ potentially encourages a new form of environmental governance promoting a cross-sectoral approach and stakeholder participation. Cohesiveness of the structures within a broader governance system is key to defining the capacity of REDD+ governance. The result also poses a question as to the inclusiveness of the state actors involved in order to tackle the different pressure on forests. Considering structural inequalities, the analysis further suggests a need of policy support for those who are affected by REDD+ to ensure that their voices could be heard in decision-making processes.
Auctions Versus Private Negotiations in Buyer-Seller Networks
Authors: Watts Alison
Published: August 2016

Buyer-seller networks where price is determined by an ascending-bid auction are important in many economic examples such as certain real estate markets, radio spectrum sharing, and buyer-supplier networks. However, it may be that some sellers are better off not participating in the auction. We consider what happens if sellers can make a take it or leave it offer to one of their linked buyers before the auction takes place and thus such a seller can choose not to participate in the auction. We give conditions on the graph and buyers valuations under which the buyer and seller will both agree to such a take it or leave it offer. Specifically, the buyer-seller pair will choose private negotiation over the auction if the seller acts as a network bridge with power over the buyer and if there are enough buyers with low valuations so that the seller does not expect to receive a high price in the auction.
Time-Dependent Injection as a Model for Rapid Blazar Flares
Authors: Zacharias Michael
Published: August 2016

Time-dependent injection can cause non-linear cooling effects, which lead to a faster energy loss of the electrons in jets. The most obvious result is the appearance of unique breaks in the SED, which would normally be attributed to a complicated electron distribution. Knowledge of the observation time and duration is important for the interpretation of the observed spectra, because of the non-trivial evolution of the spectral energy distributions (SED). Intrinsic gamma–gamma absorption processes in the emission region are only of minor importance.
DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair
Authors: Mentegari Elisa , Kissova Miroslava , Bavagnoli Laura , Maga Giovanni , Crespan Emmanuele
Published: August 2016

DNA is constantly exposed to both endogenous and exogenous damages. More than 10,000 DNA modifications are induced every day in each cell’s genome. Maintenance of the integrity of the genome is accomplished by several DNA repair systems. The core enzymes for these pathways are the DNA polymerases. Out of 17 DNA polymerases present in a mammalian cell, at least 13 are specifically devoted to DNA repair and are often acting in different pathways. DNA polymerases β and λ are involved in base excision repair of modified DNA bases and translesion synthesis past DNA lesions. Polymerase λ also participates in non-homologous end joining of DNA double-strand breaks. However, recent data have revealed that, depending on their relative levels, the cell cycle phase, the ratio between deoxy- and ribo-nucleotide pools and the interaction with particular auxiliary proteins, the repair reactions carried out by these enzymes can be an important source of genetic instability, owing to repair mistakes. This review summarizes the most recent results on the ambivalent properties of these enzymes in limiting or promoting genetic instability in mammalian cells, as well as their potential use as targets for anticancer chemotherapy.
Intrinsic Evaporative Cooling by Hygroscopic Earth Materials
Authors: Rempel Alexandra , Rempel Alan
Published: August 2016

The phase change of water from liquid to vapor is one of the most energy-intensive physical processes in nature, giving it immense potential for cooling. Diverse evaporative cooling strategies have resulted worldwide, including roof ponds and sprinklers, courtyard fountains, wind catchers with qanats, irrigated green roofs, and fan-assisted evaporative coolers. These methods all require water in bulk liquid form. The evaporation of moisture that has been sorbed from the atmosphere by hygroscopic materials is equally energy-intensive, however, yet has not been examined for its cooling potential. In arid and semi-arid climates, hygroscopic earth buildings occur widely and are known to maintain comfortable indoor temperatures, but evaporation of moisture from their walls and roofs has been regarded as unimportant since water scarcity limits irrigation and rainfall; instead, their cool interiors are attributed to well-established mass effects in delaying the transmission of sensible gains. Here, we investigate the cooling accomplished by daily cycles of moisture sorption and evaporation which, requiring only ambient humidity, we designate as “intrinsic” evaporative cooling. Connecting recent soil science to heat and moisture transport studies in building materials, we use soils, adobe, cob, unfired earth bricks, rammed earth, and limestone to reveal the effects of numerous parameters (temperature and relative humidity, material orientation, thickness, moisture retention properties, vapor diffusion resistance, and liquid transport properties) on the magnitude of intrinsic evaporative cooling and the stabilization of indoor relative humidity. We further synthesize these effects into concrete design guidance. Together, these results show that earth buildings in diverse climates have significant potential to cool themselves evaporatively through sorption of moisture from humid night air and evaporation during the following day’s heat. This finding challenges the perception of limited evaporative cooling resources in arid climates and greatly expands the applicability of evaporative cooling in contemporary buildings to water-stressed regions.
Occurrence of the Toxin-Producing Aspergillus versicolor Tiraboschi in Residential Buildings
Authors: Piontek Marlena , Łuszczyńska Katarzyna , Lechów Hanna
Published: August 2016

In an area representative of a moderate climate zone (Lubuskie Province in Poland), mycological tests in over 270 flats demonstrated the occurrence of 82 species of moulds. Aspergillus versicolor Tiraboschi was often encountered on building partitions (frequency 4: frequently). The ability to synthesize the carcinogenic sterigmatocystin (ST) means that it poses a risk to humans and animals. Biotoxicological tests of biomasses of A. versicolor were conducted in the Microbiological and Toxicological Laboratory, using the planarians Dugesia tigrina (Girard). The obtained results of the tests covered a broad range of toxicity levels of isolated strains: from weakly toxic (100–1000 mg·L−3) to potently toxic (1–10 mg·L−3). The high-performance liquid chromatography (HPLC) physicochemical method confirmed the ability of A. versicolor strains to synthesize sterigmatocystin. All of the samples of the air-dry biomasses of the fungi contained ST in the range between 0.03 and 534.38 mg·kg−1. In the bio-safety level (BSL) classification A. versicolor belongs to category 1. Additionally, A. versicolor is an allergenic mould.
National and State-Specific Attitudes toward Smoke-Free Parks among U.S. Adults
Authors: Kruger Judy , Jama Amal , Kegler Michelle , Marynak Kristy , King Brian
Published: August 2016

Outdoor places, such as parks, remain a source of secondhand smoke (SHS) exposure. We assessed attitudes toward smoke-free parks among U.S. adults. Data came from the 2009–2010 National Adult Tobacco Survey, a landline and cellular telephone survey of noninstitutionalized adults aged ≥18 in the 50 U.S. states and D.C. Descriptive statistics and logistic regression were used to assess the prevalence and sociodemographic correlates of attitudes toward smoke-free parks, overall and by current tobacco use. Overall, 38.5% of adults reported favorable attitudes toward complete smoke-free parks; prevalence ranged from 29.2% in Kentucky to 48.2% in Maine. Prevalence of favorable attitudes toward smoke-free parks was higher among nonusers of tobacco (44.6%) and noncombustible-only users (30.0%) than any combustible users (21.3%). The adjusted odds of having a favorable attitude were higher among: women; Hispanics and Black non-Hispanics, American Indian and Alaska Native non-Hispanics, and other non-Hispanics; those with an unspecified sexual orientation; and those with children aged ≤17 in the household, relative to each characteristics respective referent group. Odds were lower among: any combustible tobacco and noncombustible-only tobacco users; adults aged 45–64; and those with some college or an undergraduate degree. Opportunities exist to educate the public about the benefits of smoke-free outdoor environments.
A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification
Authors: Ponasenko Anastasia , Khutornaya Maria , Kutikhin Anton , Rutkovskaya Natalia , Tsepokina Anna , Kondyukova Natalia , Yuzhalin Arseniy , Barbarash Leonid
Published: August 2016

Severe bioprosthetic mitral valve calcification is a significant problem in cardiovascular surgery. Unfortunately, clinical markers did not demonstrate efficacy in prediction of severe bioprosthetic mitral valve calcification. Here, we examined whether a genomics-based approach is efficient in predicting the risk of severe bioprosthetic mitral valve calcification. A total of 124 consecutive Russian patients who underwent mitral valve replacement surgery were recruited. We investigated the associations of the inherited variation in innate immunity, lipid metabolism and calcium metabolism genes with severe bioprosthetic mitral valve calcification. Genotyping was conducted utilizing the TaqMan assay. Eight gene polymorphisms were significantly associated with severe bioprosthetic mitral valve calcification and were therefore included into stepwise logistic regression which identified male gender, the T/T genotype of the rs3775073 polymorphism within the TLR6 gene, the C/T genotype of the rs2229238 polymorphism within the IL6R gene, and the A/A genotype of the rs10455872 polymorphism within the LPA gene as independent predictors of severe bioprosthetic mitral valve calcification. The developed genomics-based model had fair predictive value with area under the receiver operating characteristic (ROC) curve of 0.73. In conclusion, our genomics-based approach is efficient for the prediction of severe bioprosthetic mitral valve calcification.
Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia
Authors: Koizume Shiro , Miyagi Yohei
Published: August 2016

The Warburg effect describes the phenomenon by which cancer cells obtain energy from glycolysis even under normoxic (O2-sufficient) conditions. Tumor tissues are generally exposed to hypoxia owing to inefficient and aberrant vasculature. Cancer cells have multiple molecular mechanisms to adapt to such stress conditions by reprogramming the cellular metabolism. Hypoxia-inducible factors are major transcription factors induced in cancer cells in response to hypoxia that contribute to the metabolic changes. In addition, cancer cells within hypoxic tumor areas have reduced access to serum components such as nutrients and lipids. However, the effect of such serum factor deprivation on cancer cell biology in the context of tumor hypoxia is not fully understood. Cancer cells are lipid-rich under normoxia and hypoxia, leading to the increased generation of a cellular organelle, the lipid droplet (LD). In recent years, the LD-mediated stress response mechanisms of cancer cells have been revealed. This review focuses on the production and functions of LDs in various types of cancer cells in relation to the associated cellular environment factors including tissue oxygenation status and metabolic mechanisms. This information will contribute to the current understanding of how cancer cells adapt to diverse tumor environments to promote their survival.
PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation
Authors: Bissig Christin , Rochin Leila , Van Niel Guillaume
Published: August 2016

In pigment cells, melanin synthesis takes place in specialized organelles, called melanosomes. The biogenesis and maturation of melanosomes is initiated by an unpigmented step that takes place prior to the initiation of melanin synthesis and leads to the formation of luminal fibrils deriving from the pigment cell-specific pre-melanosomal protein (PMEL). In the lumen of melanosomes, PMEL fibrils optimize sequestration and condensation of the pigment melanin. Interestingly, PMEL fibrils have been described to adopt a typical amyloid-like structure. In contrast to pathological amyloids often associated with neurodegenerative diseases, PMEL fibrils represent an emergent category of physiological amyloids due to their beneficial cellular functions. The formation of PMEL fibrils within melanosomes is tightly regulated by diverse mechanisms, such as PMEL traffic, cleavage and sorting. These mechanisms revealed increasing analogies between the formation of physiological PMEL fibrils and pathological amyloid fibrils. In this review we summarize the known mechanisms of PMEL fibrillation and discuss how the recent understanding of physiological PMEL amyloid formation may help to shed light on processes involved in pathological amyloid formation.
Synthesis and Tribological Behavior of Ultra High Molecular Weight Polyethylene (UHMWPE)-Lignin Composites
Authors: Gupta Surojit , Riyad M. , Ji Yun
Published: August 2016

In this paper, we report the synthesis and characterization of ultra-high molecular weight polyethylene (UHMWPE)-lignin composites. During this study four different compositions, namely UHMWPE, UHMWPE-13 wt. % lignin, UHMWPE-25 wt. % lignin and UHMWPE-42.5 wt. % lignin were fabricated by hot pressing. Detailed microstructural studies by scanning electron microscopy (SEM) showed that UHMWPE and UHMWPE-13 wt. % lignin had a uniform microstructure, whereas UHMWPE-25 wt. % lignin and UHMWPE-42.5 wt. % lignin samples were riddled with pores. UHMWPE and UHMWPE-13% lignin showed comparable flexural strengths of ~32.2 MPa and ~32.4 MPa, respectively. However, the flexural strength dropped drastically in UHMWPE-25 wt. % lignin and UHMWPE-42.5 wt. % samples to ~13 MPa and ~8 MPa, respectively. The tribology of UHMWPE-lignin composites is governed by the tribofilm formation. All the compositions showed similar µmean values and the specific wear rates (WR) decreased gradually as the concentration of lignin in UHMWPE was increased.
The Electrochemical Investigation of the Corrosion Rates of Welded Pipe ASTM A106 Grade B
Authors: Yingsamphancharoen Trinet , Srisuwan Nakarin , Rodchanarowan Aphichart
Published: August 2016

The aim of this work was to investigate the corrosion rate of welded carbon steel pipe (ASTM (American Society for Testing and Materials) A106 Grade B) by GTAW under the currents of 60, 70, and 80 A. All welded pipes satisfied weld procedure specifications and were verified by a procedure qualification record. The property of used materials was in agreement with the ASME standard: section IX. The welded pipe was used for schematic model corrosion measurements applied in 3.5 wt % NaCl at various flow rates and analyzed by using the electrochemical technique with Tafel’s equation. The results showed the correlation between the flow rate and the corrosion rate of the pipe; the greater the flow rate, the higher corrosion rate. Moreover, the welded pipe from the welding current of 70 A exhibited higher tensile strength and corrosion resistance than those from currents of 60 and 80 A. It indicated that the welding current of 70 A produced optimum heat for the welding of A106 pipe grade B. In addition, the microstructure of the welded pipe was observed by SEM. The phase transformation and crystallite size were analyzed by XRD and Sherrer’s equation. The results suggested that the welding current could change the microstructure and phase of the welded pipe causing change in the corrosion rate.
Hot Tensile and Fracture Behavior of 35CrMo Steel at Elevated Temperature and Strain Rate
Authors: Xiao Zhengbing , Huang Yuanchun , Liu Hui , Wang Sanxing
Published: August 2016

To better understand the tensile deformation and fracture behavior of 35CrMo steel during hot processing, uniaxial tensile tests at elevated temperatures and strain rates were performed. Effects of deformation condition on the flow behavior, strain rate sensitivity, microstructure transformation, and fracture characteristic were characterized and discussed. The results indicated that the flow stress was sensitive to the deformation condition, and fracture occurs immediately after the peak stress level is reached, especially when the temperature is low or the strain rate is high. The strain rate sensitivity increases with the deformation temperature, which indicates that formability could improve at high temperatures. Photographs showing both the fracture surfaces and the matrix near the fracture section indicated the ductile nature of the material. However, the fracture mechanisms varied according to the deformation condition, which influences the dynamic recrystallization (DRX) condition, and the DRX was accompanied by the formation of voids. For samples deformed at high temperatures or low strain rates, coalescence of numerous voids formed in the recrystallized grains is responsible for fracture, while at high strain rates or low temperatures, the grains rupture mainly by splitting because of cracks formed around the inclusions.
Decrease in Hydrogen Embrittlement Susceptibility of 10B21 Screws by Bake Aging
Authors: Chen Kuan-Jen , Hung Fei-Yi , Lui Truan-Sheng , Tseng Chien-Hao
Published: August 2016

The effects of baking on the mechanical properties and fracture characteristics of low-carbon boron (10B21) steel screws were investigated. Fracture torque tests and hydrogen content analysis were performed on baked screws to evaluate hydrogen embrittlement (HE) susceptibility. The diffusible hydrogen content within 10B21 steel dominated the fracture behavior of the screws. The fracture torque of 10B21 screws baked for a long duration was affected by released hydrogen. Secondary ion mass spectroscopy (SIMS) result showed that hydrogen content decreased with increasing baking duration, and thus the HE susceptibility of 10B21 screws improved. Diffusible hydrogen promoted crack propagation in high-stress region. The HE of 10B21 screws can be prevented by long-duration baking.
The Flotation of Kyanite and Sillimanite with Sodium Oleate as the Collector
Authors: Jin Junxun , Gao Huimin , Ren Zijie , Chen Zhijie
Published: August 2016

Kyanite and sillimanite are two polymorphic minerals with the same formula of Al2SiO5, but different crystal structures. Despite their high economic values, selectively recovering them by flotation is a challenge. In this study, the flotation behaviors of the two minerals with sodium oleate as the collector were examined at different pH conditions. Zeta potential measurement, infrared spectroscopic measurement, chemical speciation and X-ray photoelectron spectroscopy measurement were conducted to identify the underpinning mechanisms. It is found that the flotation behavior of both minerals is different under the same flotation condition. The flotation recovery of sillimanite is much higher than that of kyanite in the presence of the collector sodium oleate. Sodium oleate adsorbs onto the surfaces of kyanite and sillimanite mainly through the chemical interaction of the ionic–molecular dimers with aluminum atoms at pH 8.0. The higher sillimanite flotation recovery between the two minerals is related to the higher electrostatic charge densities of the aluminum atoms in six-fold coordination, which leads to the higher collector adsorption.
Practical and Efficient Synthesis of α-Aminophosphonic Acids Containing 1,2,3,4-Tetrahydroquinoline or 1,2,3,4-Tetrahydroisoquinoline Heterocycles
Authors: Ordóñez Mario , Arizpe Alicia , Sayago Fracisco , Jiménez Ana , Cativiela Carlos
Published: August 2016

We report here a practical and efficient synthesis of α-aminophosphonic acid incorporated into 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydroisoquinoline heterocycles, which could be considered to be conformationally constrained analogues of pipecolic acid. The principal contribution of this synthesis is the introduction of the phosphonate group in the N-acyliminium ion intermediates, obtained from activation of the quinoline and isoquinoline heterocycles or from the appropriate δ-lactam with benzyl chloroformate. Finally, the hydrolysis of phosphonate moiety with simultaneous cleavage of the carbamate afforded the target compounds.
Purification of Flavonoids from Chinese Bayberry (Morella rubra Sieb. et Zucc.) Fruit Extracts and α-Glucosidase Inhibitory Activities of Different Fractionations
Authors: Yan Shuxia , Zhang Xianan , Wen Xin , Lv Qiang , Xu Changjie , Sun Chongde , Li Xian
Published: August 2016

Chinese bayberry (Morella rubra Sieb. et Zucc.) fruit have a diverse flavonoid composition responsible for the various medicinal activities, including anti-diabetes. In the present study, efficient simultaneous purification of four flavonoid glycosides, i.e., cyanidin-3-O-glucoside (1), myricetin-3-O-rhamnoside (2), quercetin-3-O-galactoside (3), quercetin-3-O-rhamnoside (4), from Chinese bayberry pulp was established by the combination of solid phase extract (SPE) by C18 Sep-Pak® cartridge column chromatography and semi-preparative HPLC (Prep-HPLC), which was followed by HPLC and LC-MS identification. The purified flavonoid glycosides, as well as different fractions of fruit extracts of six bayberry cultivars, were investigated for α-glucosidase inhibitory activities. The flavonol extracts (50% methanol elution fraction) of six cultivars showed strong α-glucosidase inhibitory activities (IC50 = 15.4–69.5 μg/mL), which were higher than that of positive control acarbose (IC50 = 383.2 μg/mL). Four purified compounds 1–4 exerted α-glucosidase inhibitory activities, with IC50 values of 1444.3 μg/mL, 418.8 μg/mL, 556.4 μg/mL, and 491.8 μg/mL, respectively. Such results may provide important evidence for the potential anti-diabetic activity of different cultivars of Chinese bayberry fruit and the possible bioactive compounds involved.
Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer’s Disease Target
Authors: Kaufmann Dorothea , Kaur Dogra Anudeep , Tahrani Ahmad , Herrmann Florian , Wink Michael
Published: August 2016

Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer’s Disease (AD). In this study, methanol, dichloromethane and aqueous crude extracts from 80 Traditional Chinese Medical (TCM) plants were tested for their in vitro anti-acetylcholinesterase activity based on Ellman’s colorimetric assay. All three extracts of Berberis bealei (formerly Mahonia bealei), Coptis chinensis and Phellodendron chinense, which contain numerous isoquinoline alkaloids, substantially inhibited AChE. The methanol and aqueous extracts of Coptis chinensis showed IC50 values of 0.031 µg/mL and 2.5 µg/mL, therefore having an up to 100-fold stronger AChE inhibitory activity than the already known AChE inhibitor galantamine (IC50 = 4.33 µg/mL). Combinations of individual alkaloids berberine, coptisine and palmatine resulted in a synergistic enhancement of ACh inhibition. Therefore, the mode of AChE inhibition of crude extracts of Coptis chinensis, Berberis bealei and Phellodendron chinense is probably due to of this synergism of isoquinoline alkaloids. All extracts were also tested for their cytotoxicity in COS7 cells and none of the most active extracts was cytotoxic at the concentrations which inhibit AChE. Based on these results it can be stated that some TCM plants inhibit AChE via synergistic interaction of their secondary metabolites. The possibility to isolate pure lead compounds from the crude extracts or to administer these as nutraceuticals or as cheap alternative to drugs in third world countries make TCM plants a versatile source of natural inhibitors of AChE.
Effects of a Short-Term High-Nitrate Diet on Exercise Performance
Authors: Porcelli Simone , Pugliese Lorenzo , Rejc Enrico , Pavei Gaspare , Bonato Matteo , Montorsi Michela , La Torre Antonio , Rasica Letizia , Marzorati Mauro
Published: August 2016

It has been reported that nitrate supplementation can improve exercise performance. Most of the studies have used either beetroot juice or sodium nitrate as a supplement; there is lack of data on the potential ergogenic benefits of an increased dietary nitrate intake from a diet based on fruits and vegetables. Our aim was to assess whether a high-nitrate diet increases nitric oxide bioavailability and to evaluate the effects of this nutritional intervention on exercise performance. Seven healthy male subjects participated in a randomized cross-over study. They were tested before and after 6 days of a high (HND) or control (CD) nitrate diet (~8.2 mmol∙day−1 or ~2.9 mmol∙day−1, respectively). Plasma nitrate and nitrite concentrations were significantly higher in HND (127 ± 64 µM and 350 ± 120 nM, respectively) compared to CD (23 ± 10 µM and 240 ± 100 nM, respectively). In HND (vs. CD) were observed: (a) a significant reduction of oxygen consumption during moderate-intensity constant work-rate cycling exercise (1.178 ± 0.141 vs. 1.269 ± 0.136 L·min−1); (b) a significantly higher total muscle work during fatiguing, intermittent sub-maximal isometric knee extension (357.3 ± 176.1 vs. 253.6 ± 149.0 Nm·s·kg−1); (c) an improved performance in Repeated Sprint Ability test. These findings suggest that a high-nitrate diet could be a feasible and effective strategy to improve exercise performance.
The Influenza NS1 Protein: What Do We Know in Equine Influenza Virus Pathogenesis?
Authors: Barba Marta , Daly Janet
Published: August 2016

Equine influenza virus remains a serious health and potential economic problem throughout most parts of the world, despite intensive vaccination programs in some horse populations. The influenza non-structural protein 1 (NS1) has multiple functions involved in the regulation of several cellular and viral processes during influenza infection. We review the strategies that NS1 uses to facilitate virus replication and inhibit antiviral responses in the host, including sequestering of double-stranded RNA, direct modulation of protein kinase R activity and inhibition of transcription and translation of host antiviral response genes such as type I interferon. Details are provided regarding what it is known about NS1 in equine influenza, especially concerning C-terminal truncation. Further research is needed to determine the role of NS1 in equine influenza infection, which will help to understand the pathophysiology of complicated cases related to cytokine imbalance and secondary bacterial infection, and to investigate new therapeutic and vaccination strategies.
Hurricane Wind Speed Estimation Using WindSat 6 and 10 GHz Brightness Temperatures
Authors: Zhang Lei , Yin Xiao-bin , Shi Han-qing , Wang Zhen-zhan
Published: August 2016

The realistic and accurate estimation of hurricane intensity is highly desired in many scientific and operational applications. With the advance of passive microwave polarimetry, an alternative opportunity for retrieving wind speed in hurricanes has become available. A wind speed retrieval algorithm for wind speeds above 20 m/s in hurricanes has been developed by using the 6.8 and 10.7 GHz vertically and horizontally polarized brightness temperatures of WindSat. The WindSat measurements for 15 category 4 and category 5 hurricanes from 2003 to 2010 and the corresponding H*wind analysis data are used to develop and validate the retrieval model. In addition, the retrieved wind speeds are also compared to the Remote Sensing Systems (RSS) global all-weather product and stepped-frequency microwave radiometer (SFMR) measurements. The statistical results show that the mean bias and the overall root-mean-square (RMS) difference of the retrieved wind speeds with respect to the H*wind analysis data are 0.04 and 2.75 m/s, respectively, which provides an encouraging result for retrieving hurricane wind speeds over the ocean surface. The retrieved wind speeds show good agreement with the SFMR measurements. Two case studies demonstrate that the mean bias and RMS difference are 0.79 m/s and 1.79 m/s for hurricane Rita-1 and 0.63 m/s and 2.38 m/s for hurricane Rita-2, respectively. In general, the wind speed retrieval accuracy of the new model in hurricanes ranges from 2.0 m/s in light rain to 3.9 m/s in heavy rain.
A Web Service Protocol Realizing Interoperable Internet of Things Tasking Capability
Authors: Huang Chih-Yuan , Wu Cheng-Hung
Published: August 2016

The Internet of Things (IoT) is an infrastructure that interconnects uniquely-identifiable devices using the Internet. By interconnecting everyday appliances, various monitoring, and physical mashup applications can be constructed to improve human’s daily life. In general, IoT devices provide two main capabilities: sensing and tasking capabilities. While the sensing capability is similar to the World-Wide Sensor Web, this research focuses on the tasking capability. However, currently, IoT devices created by different manufacturers follow different proprietary protocols and are locked in many closed ecosystems. This heterogeneity issue impedes the interconnection between IoT devices and damages the potential of the IoT. To address this issue, this research aims at proposing an interoperable solution called tasking capability description that allows users to control different IoT devices using a uniform web service interface. This paper demonstrates the contribution of the proposed solution by interconnecting different IoT devices for different applications. In addition, the proposed solution is integrated with the OGC SensorThings API standard, which is a Web service standard defined for the IoT sensing capability. Consequently, the Extended SensorThings API can realize both IoT sensing and tasking capabilities in an integrated and interoperable manner.
Analysis of the Dynamic Sensitivity of Hemisphere-Shaped Electrostatic Sensors’ Circular Array for Charged Particle Monitoring
Authors: Tang Xin , Chen Zhong-Sheng , Li Yue , Hu Zheng , Yang Yong-Min
Published: August 2016

Electrostatic sensor arrays (ESAs) are promising in industrial applications related to charged particle monitoring. Sensitivity is a fundamental and commonly-used sensing characteristic of an ESA. However, the usually used spatial sensitivity, which is called static sensitivity here, is not proper for moving particles or capable of reflecting array signal processing algorithms integrated in an ESA. Besides, reports on ESAs for intermittent particles are scarce yet, especially lacking suitable array signal processing algorithms. To solve the problems, the dynamic sensitivity of ESA is proposed, and a hemisphere-shaped electrostatic sensors’ circular array (HSESCA) along with its application in intermittent particle monitoring are taken as an example. In detail, a sensing model of the HSESCA is built. On this basis, its array signals are analyzed; the dynamic sensitivity is thereupon defined by analyzing the processing of the array signals. Besides, a component extraction-based array signal processing algorithm for intermittent particles is proposed, and the corresponding dynamic sensitivity is analyzed quantitatively. Moreover, simulated and experimental results are discussed, which validate the accuracy of the models and the effectiveness of the relevant approaches. The proposed dynamic sensitivity of ESA, as well as the array signal processing algorithm are expected to provide references in modeling, designing and using ESAs.
Onboard Robust Visual Tracking for UAVs Using a Reliable Global-Local Object Model
Authors: Fu Changhong , Duan Ran , Kircali Dogan , Kayacan Erdal
Published: August 2016

In this paper, we present a novel onboard robust visual algorithm for long-term arbitrary 2D and 3D object tracking using a reliable global-local object model for unmanned aerial vehicle (UAV) applications, e.g., autonomous tracking and chasing a moving target. The first main approach in this novel algorithm is the use of a global matching and local tracking approach. In other words, the algorithm initially finds feature correspondences in a way that an improved binary descriptor is developed for global feature matching and an iterative Lucas–Kanade optical flow algorithm is employed for local feature tracking. The second main module is the use of an efficient local geometric filter (LGF), which handles outlier feature correspondences based on a new forward-backward pairwise dissimilarity measure, thereby maintaining pairwise geometric consistency. In the proposed LGF module, a hierarchical agglomerative clustering, i.e., bottom-up aggregation, is applied using an effective single-link method. The third proposed module is a heuristic local outlier factor (to the best of our knowledge, it is utilized for the first time to deal with outlier features in a visual tracking application), which further maximizes the representation of the target object in which we formulate outlier feature detection as a binary classification problem with the output features of the LGF module. Extensive UAV flight experiments show that the proposed visual tracker achieves real-time frame rates of more than thirty-five frames per second on an i7 processor with 640 × 512 image resolution and outperforms the most popular state-of-the-art trackers favorably in terms of robustness, efficiency and accuracy.
The Multilevel Index Decomposition of Energy-Related Carbon Emission and Its Decoupling with Economic Growth in USA
Authors: Jiang Xue-Ting , Dong Jie-Fang , Wang Xing-Min , Li Rong-Rong
Published: August 2016

The United States of America is not only an important energy consuming country, but also in the dominant position of energy for many years. As one of the two largest emitters, the US has always been trying to register a decline in energy-related CO2. In order to make a further analysis of the phenomenon, we choose a new decoupling analysis with the multilevel logarithmic mean Divisia index (LMDI) method. This study examined the contribution of factors influencing energy-related carbon emissions in the United States of America during 1990–2014, quantitatively analyzed decoupling indicators of economic development and environmental situations. As is indicated in the results, economy development and activities have a significant effect in increasing carbon emission, however, measures of energy optimization such as the improvement of energy efficiency has played a crucial role in inhibiting the carbon dioxide emission. Furthermore, as is indicated in decoupling relationship, “relative decoupling” and “no decoupling” are the main states during the examined period. In order to better investigate the long-run equilibrium relationship between total carbon dioxide emissions of each effect and the relationship between CO2 emissions and economic growth, on the basis of a static decomposition analysis, we applied a dynamic analysis method-cointegration test. At last, recommendations and improvement measures aiming at the related issues were put forward.
Effect of Crime Prevention through Environmental Design (CPTED) Measures on Active Living and Fear of Crime
Authors: Lee Jae , Park Sungjin , Jung Sanghoon
Published: August 2016

Crime prevention through environmental design (CPTED) has become a popular urban planning approach to preventing crime and mitigating fear of crime through the improvement of physical neighborhood environments. CPTED is widely used to improve deteriorated neighborhoods that suffer from crime. However, few studies have empirically examined the complex relationships among CPTED, fear of crime, and active living. Our study, therefore, investigated the effects of CPTED measures on walking frequency and fear of crime, analyzing behavioral data of residents living in participatory neighborhood regeneration areas and matched neighborhoods. We analyzed survey data from 12 neighborhoods that implemented CPTED approaches and 12 matched neighborhoods in Seoul, Korea, using structural equation modeling, which could consistently estimate complex direct and indirect relationships between a latent variable (fear of crime) and observable variables (CPTED measures and walking frequency). We designed the survey instrument as a smartphone app. Participants were recruited from 102 locations within the 24 selected neighborhoods; in total, 623 individuals returned surveys. The results revealed that sufficient closed-circuit television, street lighting, and maintenance played a significant role in mitigating fear of crime. This study has implications for planning and policy issues related to CPTED, mental health, and active living.
Integrating Economic and Ecological Benchmarking for a Sustainable Development of Hydropower
Authors: Hirsch Philipp , Schillinger Moritz , Appoloni Katharina , Burkhardt-Holm Patricia , Weigt Hannes
Published: August 2016

Hydropower reservoirs play an increasingly important role for the global electricity supply. Reservoirs are anthropogenically-dominated ecosystems because hydropower operations induce artificial water level fluctuations (WLF) that exceed natural fluctuations in frequency and amplitude. These WLF have detrimental ecological effects, which can be quantified as losses to ecosystem primary production due to lake bottoms that fall dry. To allow for a sustainable development of hydropower, these “ecological costs” of WLF need to be weighed against the “economic benefits” of hydropower that can balance and store intermittent renewable energy. We designed an economic hydropower operation model to derive WLF in large and small reservoirs for three different future energy market scenarios and quantified the according losses in ecosystem primary production in semi-natural outdoor experiments. Our results show that variations in market conditions affect WLF differently in small and large hydropower reservoirs and that increasing price volatility magnified WLF and reduced primary production. Our model allows an assessment of the trade-off between the objectives of preserving environmental resources and economic development, which lies at the core of emerging sustainability issues.
Development of Toxicological Risk Assessment Models for Acute and Chronic Exposure to Pollutants
Authors: Reichwaldt Elke , Stone Daniel , Barrington Dani , Sinang Som , Ghadouani Anas
Published: August 2016

Alert level frameworks advise agencies on a sequence of monitoring and management actions, and are implemented so as to reduce the risk of the public coming into contact with hazardous substances. Their effectiveness relies on the detection of the hazard, but with many systems not receiving any regular monitoring, pollution events often go undetected. We developed toxicological risk assessment models for acute and chronic exposure to pollutants that incorporate the probabilities that the public will come into contact with undetected pollution events, to identify the level of risk a system poses in regards to the pollutant. As a proof of concept, we successfully demonstrated that the models could be applied to determine probabilities of acute and chronic illness types related to recreational activities in waterbodies containing cyanotoxins. Using the acute model, we identified lakes that present a ‘high’ risk to develop Day Away From Work illness, and lakes that present a ‘low’ or ‘medium’ risk to develop First Aid Cases when used for swimming. The developed risk models succeeded in categorising lakes according to their risk level to the public in an objective way. Modelling by how much the probability of public exposure has to decrease to lower the risks to acceptable levels will enable authorities to identify suitable control measures and monitoring strategies. We suggest broadening the application of these models to other contaminants.
A Novel Population of Fusarium fujikuroi Isolated from Southeastern U.S. Winegrapes Reveals the Need to Re-Evaluate the Species’ Fumonisin Production
Authors: Bolton Stephanie , Brannen Phillip , Glenn Anthony
Published: August 2016

Mycotoxins pose a challenge to a safe food supply worldwide, and their threat is expected to worsen with our changing climate. The need for diligence is exemplified by the discovery of fumonisin B2 in wine, which joins ochratoxin A as a mycotoxin of concern in the grape-wine chain. To elucidate the mycotoxin risk in southeastern American wine, grape samples were collected from vineyards during harvest in 2013 and potentially mycotoxigenic fungi (Fusarium and Aspergillus) were isolated from the samples. Numerous Fusarium isolates were recovered and identified to the species level by comparison of translation elongation factor 1-α gene sequences to verified strains. Fusarium fujikuroi was the most abundant species recovered (239 isolates), followed by F. proliferatum (52), F. incarnatum-equiseti (14), F. oxysporum (7), F. concentricum (1), and F. solani (1). In vitro assays quantified fumonisin production for representative isolates via liquid chromatography-tandem mass spectrometry. Surprisingly, nearly all F. fujikuroi isolates produced fumonisins B1, B2, and B3 at levels comparable to both the F. proliferatum isolates and the positive control, Fusarium verticillioides. Such capacity for fumonisin production refutes the generally accepted notion that F. fujikuroi produces undetectable or low levels of fumonisins and provides evidence to reconsider this species as a mycotoxigenic threat to economically significant crops.
Precipitation Thresholds for Triggering Floods in the Corgo Basin, Portugal
Authors: Santos Mónica , Fragoso Marcelo
Published: August 2016

Thresholds based on critical combinations of amount/duration of precipitation and flood events were estimated for the Corgo hydrographic basin, in northern Portugal. Thirty-one flood events in the Corgo basin were identified between 1865 and 2011 from a database of hydrometeorological disasters in Portugal. The minimum, maximum, and pre-warning thresholds that define the boundaries for flood occurrence were determined. The results show that the ratio between the total number of floods and precipitation events exceeding the minimum threshold denotes a relatively low probability of successful forecasting. This result may be due to the reduced number of flooding events in the floods database, which only include floods that caused damage as reported by the media. The estimated maximum threshold is not adequate for use in floods, since the majority of true positives are below this limit. However, and more interestingly, the retrospective verification of the estimated thresholds suggests that the minimum and pre-warning thresholds are well adjusted. Therefore, the application of these precipitation thresholds may contribute to minimize possible situations of pre-crisis or immediate crisis by reducing the flood consequences and the resources involved in emergency response to flood events.
An Inscribed Bronze Sculpture of a Buddha in bhadrāsana at Museum Ranggawarsita in Semarang (Central Java, Indonesia)
Authors: Griffiths Arlo , Revire Nicolas , Sanyal Rajat
Published: August 2016

Une délicate sculpture de Buddha en bronze (ca. IXe siècle), provenant de Rejoso, près du Candi Plaosan dans la province de Java Centre, fut récemment trouvée dans les réserves du musée Ranggawarsita à Semarang. Le Buddha est assis en bhadrāsana, la posture avec les deux jambes pendantes, et les deux mains en dharmacakramudrā, soit un type iconographique fréquent en Asie du Sud et à Java au cours de la deuxième moitié du premier millénaire. Ce bronze est surtout remarquable par le texte en sanskrit inscrit au dos, écrit dans un alphabet du Nord-Est de l'Inde. L'inscription cite la formule ye dharmāḥ, à laquelle s’ajoute de manière exceptionnelle le mantra essentiel (hr̥dayamantra) jinajik. Notre étude s’attache d’abord à analyser le style et l’iconographie de ce Buddha en bronze. Nous examinons ensuite l’inscription et ses caractéristiques paléographiques. Nous étudions enfin les sources textuelles dans lesquelles ce mantra spécifique apparaît. Notre examen de l’œuvre et de son inscription tente de résoudre les questions de provenance et de datation, ainsi que celle, controversée, de l’identité du Buddha représenté. Nous proposons de voir dans cette sculpture en bronze une manifestation universelle et impériale de la bouddhéité. Selon nous, cette pièce inscrite permet de mieux comprendre certains concepts de l’iconographie tantrique bouddhique à date ancienne, à Java et ailleurs.