bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of perinatal outcomes in pregnant women with fetal growth retardation
Authors: Dolgushina V. F. , Vereina N. K. , Fartunina Ju. V. , Nadvikova T. V.
Published: November 2021

Introduction. An important problem of modern obstetrics is the development and improvement of methods for predicting fetal growth retardation (FGR) and pregnancy outcomes in this pathology, since there are no proven effective treatments for FGR. Purpose of the study — to develop prediction criteria for newborn hypotrophy and cumulative adverse perinatal outcome in pregnant women with FGR. Objective. To identify key predictive factors for adverse perinatal outcomes in pregnancy complicated by FGR. Material and methods. A case-control, cohort-based study was conducted that included 155 pregnant women with FGR, who were divided into two groups after delivery: Group 1 included 90 patients with neonatal hypotrophy and Group 2 included 65 patients without neonatal hypotrophy. A comprehensive analysis of clinical and anamnestic, laboratory and instrumental data, peculiarities of the course of pregnancy and perinatal outcomes was performed. FGR was determined on the basis of ultrasound fetometry. Results. Factors associated with neonatal hypotrophy and unfavorable perinatal outcome were: impaired blood flow in the uterine arteries and/or umbilical artery, early preeclampsia and scarcity of water. Protective factors were antibacterial therapy for intrauterine infection, administration of low-molecular-weight heparin in the first trimester, and acetylsalicylic acid starting from the 12th to 16th weeks of gestation. Conclusion. The most promising measures in the prevention of FGR and adverse perinatal outcomes in this pathology may be timely prescription of antithrombotic correction and treatment of genital infections.
Professional expectations of medical university graduates in solving the issues of health care system staffing
Authors: Tjukov Ju. A. , Matveeva E. S. , Berezina A. M.
Published: November 2021

Introduction. At present, in most regions of the Russian Federation there is a shortage of medical personnel in the public health system. The issue is particularly acute in medical organizations providing primary health care, as well as in municipal districts remote from the regional center. The purpose of the paper is to examine the professional expectations and intentions of medical university students. Materials and methods. The method of questioning was applied in the study. Questionnaires were taken by 296 students of the fifth year of the specialties «Medicine» and «Pediatrics», studying on the budget and commercial forms of education.Results. Only 22% of respondents considered primary care as a place of work. Large cities are chosen for work by 90% of respondents, and 42% of them would like to leave their home region and find a job in economically more attractive regions. Only 6% of respondents are ready to go to the countryside, and 4% of respondents are interested in ambulance service. Approximately evenly distributed were opinions on work in public and private health care system, respectively, 54% and 56% of respondents. At the stage of graduation, 16.6% of the students were disappointed in their chosen profession, another 22.3% found it difficult to answer, and 5.7% do not plan to stay in healthcare after graduation. Discussion. The main reasons for this situation are salaries that do not meet the needs of graduates, especially at the start of their professional career, the social unsettlement of young doctors, mainly in small towns and rural areas, and insufficient practical training. Conclusion. The solution to the problem lies in the sphere of socio-economic provision of living conditions and stimulation of quality training of specialists, taking into account professional orientation.
Clinical experience with idarucizumab prior to thrombolytic therapy of cerebral infarction in the Sverdlovsk region
Authors: Yurovskikh N. V. , Jarygina G. V.
Published: November 2021

Introduction. In recent years, the use of oral anticoagulants for the prevention of ischemic strokes (IS) in patients with atrial fibrillation (AF), as well as the prevention of deep vein thrombosis and thromboembolism has been increasing in clinical practice. According to epidemiological studies, ischemic strokes account for about 85% of all AMI. Cardioembolic strokes (CES), which develop due to embolism to the cerebral vessels from the heart chambers, deserve special attention. The presence of AF is associated with a twofold increase in the risk of death from cardiovascular disease and death from any cause. Timely anticoagulant therapy can reduce the risk of thromboembolic complications and improve the prognosis. Materials and Methods. The authors present a clinical observation in which a 47-year-old female patient diagnosed with venous insufficiency, who took dabigatran 150 mg twice a day for a year, developed IS with left-sided pronounced hemiparesis. After 170 minutes from the development of the stroke, idarucizumab was administered to neutralize the anticoagulant effect of dabigatran and thrombolytic therapy (TLT) was performed. Results. Twenty-four hours after TLT, the National Institutes of Health Stroke Scale (NIHSS) score decreased from 16 to 6. A repeat CT scan of the brain revealed a focus of ischemia in the right frontal, parietal, and temporal lobes. On the 19th day of the AI, dabigatran 150 mg 2 times a day was resumed. Conclusion. The presented observation confirms that in patients with AI developed against the background of dabigatran, the administration of idarucizumab is safe and allows for TLT.
The impact of e-commerce drivers on e-customer loyalty: Evidence from KSA
Authors: Al-Ayed Sura
Published: November 2021

E-commerce and online shopping is the future of global trade, hence the importance of building E-customer loyalty and maintaining it in the electronic markets becomes even more important. This paper attempts to identify factors affecting the value of electronic commerce in the Saudi environment. Likewise, it explores the impact of these factors on E- customer loyalty. Simple random sampling was used for the purposes of the current study, as the first study included 247 electronic customers. Data were collected through electronic questionnaires sent to the study participants. The results show that the factors had a positive impact in building E- customer loyalty Care, Character, Choice, Convenience, Customization, and Cultivation. Basically, e-commerce is considered a pioneer in business organizations today, and this is witnessed by its increasing and growing profits and expanding its market share, through its focus on the E-loyalty customers. Basically, e-commerce is considered a pioneer in business organizations today, and this is witnessed by its increasing and growing profits and expanding its market share, through its focus on the E-loyalty customers.
A comprehensive acceptance model for smart home services
Authors: Al-Husamiyah Amer , Al-Bashayreh Mahmood
Published: November 2021

Smart home services (SHSs) afford users an effective lifestyle management system, which provides human-oriented networking of smart devices and applications that enable users to control their homes from anywhere at any time. Despite the benefits of SHSs, however, their acceptance is very low. There remains a gap in the literature in terms of a comprehensive model that addresses users’ intention to use SHSs. To address this gap, the present study explored the factors that influence SHS acceptance among users based on well-established theoretical frameworks, such as the technology acceptance model, innovation diffusion theory, and the theory of planned behavior. To this end, the study integrated four additional factors, namely, perceived convenience, perceived connectedness, perceived cost, and perceived privacy risk, into the exploration and carried out structural equation modeling to quantitatively determine the effects of these factors. Questionnaires were administered to 750 users. The findings indicated that perceived compatibility, perceived convenience, perceived connectedness, perceived cost, perceived behavioral control with perceived usefulness, and perceived ease of use directly and indirectly exerted a significant influence on users’ intention to use SHSs.
The influence of social media marketing, product innovation and market orientation on Indonesian SMEs marketing performance
Authors: Khamaludin Khamaludin , Syam Syahriani , Rismaningsih Febri , Lusiani Lusiani , Arlianti Lily , Herlani Ahmad Fajar , Fahlevi Mochammad , Rahmadi Raendhi , Windyasari Vina Septiana , Widiyatun Fita
Published: November 2021

The purpose of this study is to analyze the influence of social media marketing, product innovation, market orientation on marketing performance. The study uses quantitative methods and data analysis techniques are based on Structural Equation Modeling using SmartPLS 3.0 software. The sample selection method uses the snowball sampling method. Online questionnaires are sent to 320 SMEs in Banten Province, where 300 responses are used. The results of data analysis show that social media marketing has a significant effect on marketing performance, product innovation has a significant effect on marketing performance and market orientation has a significant effect on marketing performance.
Gender and age in the language of social media: An easier way to build credibility
Authors: Marhaeni A.A.I.N. , Yasa I G W Murjana , Fahlevi Mochammad
Published: November 2021

The use of celebrity endorsements is one of the most popular strategies used by companies today. Celebrities can bring product advantages through advertising and go beyond the complexities of competitive advertising communications. The company invests a large amount of money to get the attention of consumers and gain a competitive position in the market. The purpose of this study is to explore the effect of celebrity trust on the credibility of advertisements, brands, and companies, then the influence between the credibility of advertisements, brands, and companies, and will also explore the role of gender and age as moderating variables. The study used a quantitative method, the sample was taken based on purposive sampling in Jakarta and used the artist with the most followers as the object of research who endorsed food and beverage companies. The results of this study explain that there is a significant influence between celebrity trust on all credibility, gender and age managed to moderate the influence of celebrity trust on credibility. This study provides input to managers and food and beverage companies in using endorsements on Instagram social media as their marketing strategy, especially for companies that have a market share of young people in accordance with the characteristics of the respondents in this study.
METHOD DEVELOPMENT AND VALIDATION OF RP-HPLC FOR THE SIMULTANEOUS ESTIMATION OF ESCITALOPRAM AND ETIZOLAM IN BULK AND PHARMACEUTICAL DOSAGE FORM
Authors: Vadrevu S. , Govindarao K. ,   Aditya pharmacy college, Aditya Nagar, Surampalem - 533 437, Andhra Pradesh, India
Published: November 2021

The developed RP-HPLC method allows rapid and precise determinations of escitalopram and etizolam in bulk and pharmaceutical dosage forms. The objective of the proposed method was to develop a simple and accurate method for the determination of escitalopram and etizolam by RP-HPLC method in pharmaceutical dosage forms & its stability indicative studies. A series of mobile phases were tried; among the various mobile phases , potassium dihydrogen phosphate buffer and dipotassium hydrogen phosphate 0.02 M, pH 3.0 : acetonitrile (20:80) is an ideal mobile phase, since it gave a good resolution and peak shapes with perfect optimization. The flow rate was optimized at less than 2 mL/min. The linearity and correlation coefficient of escitalopram and etizolam at 0-45μg/mL and 0-75μg/mL was found to be 0.998 & 0.998, respectively. The LOD was found to be 0.1 mg/mL and 0.3 mg/mL and LOQ was found to be 0.15 mg/mL and 0.45 mg/mL for escitalopram and etizolam, respectively, which represents that sensitivity of the method is high. The method was known to be accurate with the assay method. The % assay was found to be 100 % and 98%. The developed method showed a good accuracy and precision. The % RSD is for escitalopram and etizolam was found to be 1.50 and 1.22. This method shows good reproducibility of the results. Furthermore, this method was simple, sensitive, and accurate. Hence, the chromatographic method developed for escitalopram & eizolam can be effectively applied for routine analysis.
DEVELOPMENT OF LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF BROMHEXINE HYDROCHLORIDE AND ENROFLOXACIN IN FORMULATIONS
Authors: Choksi P , Shaikh F. , Shah D. A. , Agarwal K. , Mehta F. A , Patel V. B ,   Babaria Institute of Pharmacy, Vadodara – Mumbai National Highway 8, Varnama, Vadodara - 391240, Gujarat, India
Published: November 2021

A simple, specific, accurate, precise and reproducible method has been developed and validated for the estimation of bromhexine hydrochloride and enrofloxacin in fixed dose combination using RP-HPLC. The separation was achieved using stationary phase ODS Hypersil C18 column (250 mm× 4.6 mm i.d.) in isocratic mode, with mobile phase containing 0.05 M potassium dihydrogen phosphate buffer (pH 4 by o-phosphoric acid) : methanol: acetonitrile : triethylamine (40:20:40:01), at a flow rate of 1.0mL/min and eluents were monitored at 256 nm. The retention time of enrofloxacin and bromhexine HCl were found to be 3.00 min and 5.1 min respectively. The linearity for bromhexine HCl and enrofloxacin was in the range of 2-15 μg/mL and 20-150 μg/mL, respectively. The method was validated as per ICH guideline. The recoveries of bromhexine HCl and enrofloxacin were found in the range of 99.61-101.65% and 99.52-100.13 %, respectively. The method was successfully applied for the determination of both the drugs in combined dosage form.
COMPATIBILITY STUDY OF ALOGLIPTIN BENZOATE WITH WIDELY USED PHARMACEUTICAL EXCIPIENTS FOR SOLID DOSAGE FORM
Authors: Nandi U , Dahiya M. , Prakash A , Kumar R. , Singh G. N ,   Reference Standard Division, Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Govt. of India, Sector-23, Rajnagar, Ghaziabad - 201002, Uttar Pradesh, India
Published: November 2021

Alogliptin is a new dipeptidyl peptidase-4 (DPP-4) inhibitor for oral diabetes care. The present study aims to evaluate the compatibility of alogliptin benzoate with the extensively used pharmaceutical excipients for solid dosage form. This can be achieved by applying Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) techniques together with Fourier-Transform Infrared spectroscopy (FT-IR) as paired technique to aid in the interpretation of outcome. Chosen excipients were Cross carmellose sodium, microcrystalline cellulose, magnesium stearate, sodium starch glycolate, and pregelatinised starch. Results illustrated that drug was compatible with all the excipients except magnesium stearate where a slight degree of physical interaction was observed but mass loss due to degradation was not hastened in TGA. FT-IR study lined out any chemical change of drug with magnesium stearate. These results would be valuable for formulation development of the film coated tablets of alogliptin benzoate.
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR FLUTICASONE FUROATE AND VILANTEROL IN PHARMACEUTICAL FORMULATIONS
Authors: Masimukku S. K. , Chintala R. ,   Department of Chemistry, K.B.N. P.G. College, Vijayawada - 520 001 Andhra Pradesh, India.
Published: November 2021

A simple, rapid, accurate and stability indicating High Performance Liquid Chromatographic method was developed and validated for the simultaneous determination of vilanterol (VTL) and fluticasone furoate (FFE) in pure and in pharmaceutical formulations using C18 Column and methanol: acetonitrile: 1% sodium perchlorate in the ratio 50:40:10 v/v/v as mobile phase at pH 4.8 and flow rate of 1 mL/min with isocratic elution. The eluted compounds were detected using UV7000 detector at a wavelength of 254nm. The retention times of VTL and FFE were found to be 4.54 and 7.65 min, respectively, with a correlation coefficient of 0.9990 each. The linearity ranges for VTL and FFE were found to be 2.5–15μg/ml and 10–60μg/ml respectively. The LOD and LOQ values were observed to be 0.001μg/mL and 0.02μg/mL for VTL and 0.005μg/mL and 0.07μg/mL for FFE. The percentage recovery was found to be in range of 98.37 – 99.84 % and 98.46 –101.42 % for VTL and FFE, respectively. Both the drugs were subjected to acid, base, hydrolysis, oxidation, photolytic and thermal degradation conditions. The degradation products of VTL and FFE were well resolved from the pure drug with significant differences in their retention time values. This validated method was applied for the simultaneous estimation of VTL and FFE in a commercially available formulation sample.
MICROWAVE ASSISTED SYNTHESIS OF BIPHENYL BASED SCHIFF’S BASES AND THEIR ANTIMICROBIAL EVALUATION
Authors: Somani R. , Dubey P. , Zine S. ,   Department of Pharmaceutical Chemistry, Vivekanand Education Society’s College of Pharmacy, Chembur (E), Mumbai - 400 074, Maharashtra, India.
Published: November 2021

Schiff’s base constitutes a significant class of compounds for new drug development. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The search for Schiff’s base containing compounds with more selective activity and lower side effects continues to be an active area of argument examination in medicinal chemistry. The biphenyl molecule consists of two connected phenyl rings. Biphenyl ring scaffolds are fairly non-reactive in nature. They enhance the log-P values; increase the tropical polar surface area (TPSA) of the molecule, act as hydrophobic carrier across biological membrane, thus, increasing the bioavailability of compounds. In the present work, a series of Schiff’s bases of biphenyl-4-carboxylic acid have been synthesized. These derivatives were characterized by elemental analysis, IR, and 1H NMR spectral data and have been explored for anti-bacterial, anti-fungal and anti-tubercular activities. The synthesized compounds have shown excellent anti-fungal potential, making them good candidates for future studies in antifungal research.
METHOD DEVELOPMENT AND VALIDATION OF LENVATINIB BY HPLC AND UV-SPECTROSCOPY
Authors: Patve R. S. M , Shaikh A. R. , Inamdar N , Bhise K. ,   M.C.E. Society’s, Allana College of Pharmacy, Azam Campus, Camp, Pune - 411001,Maharashtra, India
Published: November 2021

A simple rapid, accurate, precise and reproducible validated UV spectroscopy, RP-HPLC method was were developed for the determination of lenvatinib in bulk forms. The quantification was carried out using HiQSil 4.6 X 250 mm, 5μ, C8 column, run in isocratic way using mobile phase comprising of methanol: ammonium acetate buffer 30:70 by volume, pH-3.5 adjusted with orthophosphoric acid and a detection wavelength of 301mm, and injection volume of 20μL, with a flow rate of 1.0mL/min. The retention time of lenvatinib was found to be 4.383 min., the linearity range of the proposed method lies between 10-40 μg/mL (r²=0.9992). recovery studies were also carried out and mean % recovery was found to be 99.05 for lenvatinib. LOD and LOQ values for lenvatinib were found to be 0.992 and 2.79 respectively. The proposed method was statistically evaluated and may be applied for routine quality control analysis of lenvatinib in bulk.
SIMULTANEOUS DETERMINATION AND QUANTITATION OF METFORMIN AND TENELIGLIPTIN IN HUMAN PLASMA BY LC-ESI-MS/MS WITH AN APPLICATION TO PHARMACOKINETIC STUDIES
Authors: Mandal P , Dan S , Ghosh B. , Barma S. , Bose R. , Pal T. K ,   Dept. of Pharm. Tech., Jadavpur University, Kolkata - 700 032, India
Published: November 2021

‘Gliptins’ is the nickname given to a group of anti-diabetic medicines-DPP-4 inhibitors, such as sitagliptin, vildagliptin, sexagliptin, linagliptin, alogliptin and teneligliptin, which are used with metformin for combination therapy of type 2 diabetes mellitus. Advantages of this combined therapy are low risks of hypoglycemia and weight gain compared with other classes of anti-diabetic drugs. In the present study efforts, were made to develop and validate a bioanalytical method for simultaneous estimation of metformin and teneligliptin in human plasma by LC-MS/MS with an application to quantification of plasma samples obtained from the comparative pharmacokinetic studies on healthy human volunteers. The developed method for simultaneous determination and quantification of teneligliptin and metformin in human plasma was also validated as per the US-FDA guidelines. The validation parameters were found to be within the specified regulatory limits, hence the method acceptable. The present method had a short run time (3.5min) and easy extraction process. Therefore, developed method was found to be simple, specific, highly selective, sensitive and reproducible. This was applied for the analysis of volunteer plasma samples obtained from comparative pharmacokinetic study. On the basis of comparison of AUC0-t, the relative bioavailability of test preparation was found to be 97.64% and 91.37% for teneligliptin and metformin, with respect to that of the reference preparation.
Proximate and Sensory Analysis of Functional Drink from Jackfruit Seed Extract with Citrulline Fortification As A Potential Antidiabetic
Authors: Gunawan William Ben , Priambodo Amelia Septyn , Winarti Diah , Nurohma Aprilia , Wijayanti Laurencia Okky
Published: November 2021

The World Health Organization (WHO) predicts that diabetes Mellitus in Indonesia by 2030 will increase to 21.3 million people. There was a growing need for natural foods that can be used as a substitute for antihyperglycemic drugs and may lower the blood sugar levels of diabetes Mellitus patients without burdening the kidneys and causing other side effects. Citrulline, one of the amino acids that are useful for the immune system and improving blood flow circulation, is found in the white peel of watermelon in greater levels compared to the citrulline content of other fruits. Previous research has shown that citrulline supplementation significantly lowered fasting blood sugar and HbA1c as well as inflammatory biomarkers, including in obese subjects. Methods conducted in this study include watermelon peel extract making, jackfruit seed drink making, proximate analysis, total phenol testing, organoleptic testing, and data analysis. The results of proximate testing on jackfruit seed drink with additional citrulline (F1) were F1 samples consisting of 92.31% water, 0.47% protein, 0.99% fat, 0.00% ash, and 6.23% total carbohydrates. Sensory analysis revealed that the flavor of the drink was disliked, while the aroma of the drink was somewhat liked. The addition of watermelon peel extract in jackfruit seed drinks may increase nutrition value, antioxidant content, and has the potential to be a functional drink with antioxidant content and blood sugar reduction effects as antidiabetics.
Vancomycin Resistance in Staphylococcus aureus and Enterococcus Species isolated at the University Teaching Hospitals, Lusaka, Zambia: Should We Be Worried?
Authors:   The University of Zambia, Mutalange Matenge , Yamba Kaunda ,   University Teaching Hospital, Kapesa Chiristine ,   University Teaching Hospital, Mtonga Frank ,   The University of Zambia, Banda Masiye ,   The University of Zambia, Muma John B. ,   The University of Zambia, Hangombe Bernard M. ,   The University of Zambia, Hachaambwa Lottie , Bumbangi Flavien N. ,   Eden University, Kwenda Geoffrey ,   The University of Zambia, Samutela Mulemba T. ,   The University of Zambia
Published: November 2021

Background: Staphylococcus aureus and Enterococcus species cause invasive infections such as bacteremia and infective endocarditis. Despite vancomycin being the drug of choice for drug-resistant infections caused by these species, few studies have been conducted to ascertain vancomycin resistance in the African setting. This is crucial given the rising resistance in these organisms. This study aimed to isolate S. aureus and Enterococcus species and determine their susceptibility to vancomycin and other antibiotics at the University Teaching Hospitals in Lusaka, Zambia. Methods: This was a cross-sectional study in which S. aureus and Enterococcus spp isolates from the skin, soft tissue and bloodstream infections were included. Standard microbiological and Kirby-Baur (disc diffusion and E-strips) methods were used to identify and determine the susceptibility of the organisms, respectively. Results: From 59 S. aureus isolates, 37 were from the skin and soft tissue and 22 from blood culture. Twenty-six (44.1%) of these were Methicillin-resistant S. aureus. Thirty-nine Enterococcus were isolated from blood cultures only. Of the S. aureus (16) and Enterococcus (14) isolates tested with vancomycin E-strips, none were vancomycin-resistant. However, 12.5% S. aureus and 14.3% Enterococcus showed intermediate vancomycin susceptibility. S. aureus were resistant to penicillin (93.2%), erythromycin (52.5%) and tetracycline (50.8%). Enterococcus showed resistance to penicillin (83%) and tetracycline (84.6%). Conclusions: There was no vancomycin resistance among S. aureus and Enterococcus, implying vancomycin is still a viable treatment option for invasive infections. Given the intermediate vancomycin susceptibility, treatment guided by minimum inhibitory concentration results, continued surveillance and prudent use are key.
Identification of MHC Alleles Associated With Disease Resistance/Susceptibility In Smallholder Cattle In Zambia
Authors:   Livestock Services Cooperative Society, Silwamba Isaac K. , Simuunza Martin ,   The University of Zambia, Ndebe Joseph ,   The University of Zambia, Simulundu Edgar ,   Macha Research Trust, Mainda Geoffrey ,   Central Veterinary Research Insitute, Muma John B. ,   The University of Zambia
Published: November 2021

Background: The occurrence of Major Histocompatibility complex (MHC) alleles associated with resistance to Mastitis, Bovine Leukaemia Virus (BLV), Theileriosis, Foot and Mouth Disease (FMD) and susceptibility Dermatophilosis in African cattle is ill defined. Methods: Here, we used manual annotation to screen for five MHC alleles previously known to be associated with resistance/susceptibility to these diseases from a database of alleles sequenced from 846 cattle in Zambia. Results: Overall, we found 28 (3.3%), 21 (2.6%), 55 (6.5%), and 15 (1.8%) animals with resistance alleles to Mastitis, BLV, Theileriosis, FMD and 39 (4.6%) animals with susceptibility alleles to Dermatophilosis, respectively. Conclusion: This study provides the first evidence of resistance/susceptibility alleles in smallholder cattle in Zambia and the data could aid strategies for breeding cattle with enhanced resistance to disease in endemic countries.
Slaapstoornissen en epilepsie: is het van belang?
Authors: Van Kasteel Viviane
Published: November 2021

Het is bekend dat mensen met epilepsie vaker slaapproblemen hebben dan mensen zonder epilepsie. Daarnaast kunnen nachtelijke aanvalsgewijze slaapstoornissen moeilijk te onderscheiden zijn van epileptische aanvallen. Ook kan behandeling van epilepsie invloed hebben op de slaap. Het is van belang om deze complexe relatie tussen epilepsie en slaap te onderkennen bij mensen met epilepsie.
Voor en na epilepsiechirurgie: achterstand in sociale ontwikkeling
Authors: Jennekens-Schinkel Aag
Published: November 2021

Olga Braams promoveerde op 9 mei 2019 aan de Universiteit Utrecht op het proefschrift Social matters. Before and after epilepsy surgery in children1. In haar onderzoek werden de volgende vragen gesteld, die ten grondslag liggen aan dit proefschrift. Was de operatie een kantelpunt in de ontwikkeling van sociaal functioneren, als basis van cognitieve maar ook affectieve ontwikkeling? Konden bepalende invloeden vastgesteld worden?
Assessing the performance of multi-sources gridded data to estimate long-term rainfall change over north-central region of India
Authors: JAVED AKHTER , DEBJYOTI MAJUMDER , ARGHA DEB , LALU DAS
Published: November 2021

As station data quality and availability is not adequate to reliably estimate observed climate change over many parts of the country, multi sources observational gridded datasets have been employed in the present study. The performances of multi-observational gridded datasets, e.g., IMD gridded data, CRU, APHRODITE, GPCC, NCAR/NCEP reanalysis have been compared with the reference rainfall data from IITM over North central India (NCI), a region of subtropical monsoon climate, during four main seasons (MAM,JJAS,ON and DJF) as well as in annual scale for the period 1951-2003. All the gridded data except CRU and NCEP have secured good skill scores in all seasons as well as at annual scale. APHRODITE and NCEP reanalysis have shown large wet bias in all seasons. The reference rainfall data over NCI has shown 6.3 mm, 4.2 mm, 1.9 mm and 11.2 mm increase per decade for MAM, JJAS, DJF seasons and annual rainfall respectively whereas 2.2 mm decrease per decade has been found for ON season. Only GPCC dataset have been able to capture similar trend for all seasons. Performance of NCEP reanalysis has been worse in compared to others. GPCC and IMD high resolution data has shown smallest bias among all the datasets and also obtain superior skill scores than others. Therefore based on visual inspection and the results from different conventional measures, GPCC high resolution gridded data and high resolution IMD gridded data may be reliably used for climatic analysis of this region.
HOT WEATHER SEASON (March-May 2019)†
Authors: Anupam Kashyapi , P R Abhang , J. C. Natu , V. K. Shripad
Published: November 2021

The first cyclonic storm of the season, Extremely Severe Cyclonic Storm (ESCS “Fani” 26th April - 4th May, 2019) formed over the Bay of Bengal and crossed the Odisha coast close to Puri. Besides this ESCS, one short lived low pressure area formed on 30th May over southwest Arabian Sea off Somalia coast which dissipated on 31st May.
MONSOON SEASON (June - September 2019)
Authors: Mausam Editor
Published: November 2021

The rainfall over the country as a whole during the monsoon season (June-September) was 110% of its Long Period Average (LPA) and thus categorized as a normal* monsoon year. Seasonal rainfall over Central India region (1263.2 mm) was large excess with 129% of LPA rainfallwhich was third highest since 1901 after the years 1994 (1311.3 mm) and 1961 (1297 mm) for the broad geographical region of Central India. Rainfall over South Peninsula (116% of LPA) region was excess, over Northwest India (99% of LPA) was normal and East and Northeast Region remained deficient at 88% of LPA. Southwest monsoon reached parts over the Andaman Sea on 18 May, two days earlier than its normal date. However, it set in over Kerala on 8 June, 7 days later than its normal date and covered the entire country by 19 July with a delay of 4 days. Typically, the monsoon current begins to withdraw around 1 September, with the retreat completed by 15 October. This year, the retreat began on 9 October, marking the longest ever delay and was complete by 16 October in just 8 days. The withdrawal of Southwest monsoon from the entire country and the commencement of the Northeast monsoon rains occurred simultaneously on 16 October. Sometimes there is a gap of 10 days between the two seasons. Due to neutral ENSO conditions and weak Madden Julian Oscillation (MJO), their influence on the monsoon were nearly absent especially in the second half of the season. Positive Indian Ocean Dipole (IOD) episode was observed since the beginning of the monsoon season and its rapid strengthening to the strongest ever was observed by mid of the monsoon season.
Influence of Indian Ocean dipole on rainfall variability and extremes over southern Africa
Authors: B. A. OGWANG , V. ONGOMA , Z. W. SHILENJE , T. S. RAMOTUBEI , M. LETUMA , J. N. NGAINA
Published: November 2021

Extreme weather events; floods and droughts are common in southern Africa (SA) consisting of 8 countries (Botswana, Namibia, South Africa, Lesotho, Swaziland, Mozambique, Zimbabwe, parts of Angola and Zambia). This study examines the linkage between the SA October-December (OND) rainfall, the Indian Ocean Dipole (IOD) and the South Atlantic Oscillation Dipole (SAOD). Empirical Orthogonal Functions (EOF) technique is used to establish the dominant mode of variability of OND rainfall, as correlation analysis is applied to quantify the relationship between the indices; IOD [Dipole Mode Index (DMI)], SAOD Index (SAODI) and OND rainfall variability. Results show that the dominant mode of variability of OND rainfall exhibits a dipole pattern over SA and there exists a significant correlation at 95% confidence level between the area average OND rainfall (rainfall index (RFI)) and DMI, with a correlation coefficient of -0.3. The relationship between the mean SA OND rainfall and the positive phase of IOD varies greatly in space, ranging from one country to another. Further analysis of the dry and wet of SAOND rainfall years reveal that wet years are associated with convergence at  surface level (850 hPa) and divergence at upper level (200 hPa), depicting rising motion in the region, whereas dry years are associated with divergence at low level and convergence at upper level, implying descending motion. The study recommends further research on a reduced spatial scale, for instance at a country level to ascertain the effect of IOD on individual country’s weather. This will help in accurate monitoring of the evolution of IOD events to improve quality of seasonal weather forecasts in the region.
Fragilidade, desempenho cognitivo e sintomas depressivos de idosos ribeirinhos da Amazônia
Authors: Gomes do Nascimento Rodolfo , Da Silva Pinto Denise , Colino Magalhães Celina Maria , De Oliveira Cardoso Ronald , Da Costa Cunha Katiane , De Souza Piedade Anna Beatriz , Rodrigues Puga Giovana
Published: November 2021

A síndrome de fragilidade é uma condição clínica em que se observa um aumento no estado de vulnerabilidade do indivíduo envolvendo diversos fatores de ordem biopsicossociais. O objetivo foi investigar o desempenho cognitivo, sintomas depressivos e fragilidade entre idosos ribeirinhos amazônicos, bem como a associação entre essas variáveis. Trata-se de um estudo observacional do tipo transversal de abordagem quantitativa realizado no município de Cametá, Pará, Brasil. Participaram do estudo 108 idosos, a coleta de dados foi por meio do fenótipo de fragilidade postulado por Fried et al. (2001) modificado, Miniexame do Estado Mental (MEEM) e Escala de Depressão Geriátrica (EDG-15). Constatou-se que a maioria dos ribeirinhos foram classificados como idosos não frágeis, além disso, o comprometimento cognitivo e a presença de sintomas depressivos consolidaram-se como fatores associados à condição de fragilidade (p = 0.0468 e p = 0.0032). Por fim, destaca-se a importância da gestão da fragilidade em idosos de comunidades tradicionais brasileiras.
HERMENEUTIKA TEOLOGI PENTAKOSTA
Authors: Hinna Jefri
Published: November 2021

The term hermeneutic comes from the Greek word hermeneuo, which means to convey (a thought or desire), explain (a speech), and translate (something from one language to another). This word is related to the god Hermes, a god in Greek mythology whose job is to convey the message of the gods to humans as recipients. Hermeneutics has always been used as the science and art of interpreting Scripture. It is important to note that hermeneutics is closely related to biblical studies, such as canon studies, textual criticism, historical criticism, exegesis, biblical theology and systematic theology.

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Istilah hermeneutic berasal dari kata Yunani hermeneuo, yang berarti menyampaikan (suatu pikiran atau keinginan), menjelaskan (suatu ucapan), dan menerjemahkan (sesuatu dari satu bahasa ke bahasa yang lain). Kata ini berhubungan dengan Dewa Hermes yaitu dewa dalam mitologi Yunani yang bertugas menyampaikan berita dari para dewa kepada manusia sebagai penerimanya.1  Hermeneutik selalu digunakan sebagai ilmu pengetahuan serta seni dari penafsiran kitab Suci.   Penting untuk diperhatikan bahwa hermeneutik berkaitan erat dengan kajian-kajian alkitabiah, seperti, kajian kanon, kritik teks, kritik historis, eksegesis, teologi alkitabiah serta teologi sistematis.
History of the Development of Sekolah Tinggi Teologi Satyabhakti
Authors: Hinna Jefri
Published: November 2021

Education is important for the current global changes. Education leads human beings to grow in knowledge as well.  Charles A. Tidwel says, “Persons have an inherent capacity for growing and developing physically, intellectually, emotionally, and morally.” Furthermore, Tidwell emphasizes that human being is created by God as an intelligent being.  Human beings are intelligent people and they will grow in their knowledge according to what they have learned in their life. They learn from what they have seen and heard, then will lead them into a change. To live means to change. Therefore, change is the essence of life. Change is inescapable and the Church today experience the change of the society.
Clark H. Pinnock, Flame of Love: A Theology of the Holy Spirit. Downers Grove: Intervarsity Press, 1996. 280 pp.
Authors: Wiyono Gani
Published: November 2021

Flame of Love is written by Clark Pinnock of McMaster Divinity College, one of the most evangelical stimulating theologians today.  It is basically a one-volume systematic theology with the Spirit as its central motif.  Chapter one discusses the Spirit and the Trinity.  Here, Pinnock develops a relational (or social) model of God which views Godhead as a community of love and mutuality.
Tanggung jawab Penggembalaan berdasarkan Perspektif 1 Petrus 5:1-4
Authors: Sapan Sara , Dominggus Dicky
Published: November 2021

This article discusses pastoral responsibilities from the perspective of 1 Peter 5: 1-4. In general, the pastor's responsibility is to care for God's church in spirituality. But specifically Peter wrote the pastor's responsibilities such as not by force but by volunteering, not looking for one's own benefit but with enthusiasm and not using power but to be an example. This article aims to understand pastoral responsibility in the perspective of 1 Peter 5: 1-4 and find its implications for pastoral today. The method used in this study is a qualitative method with a Historical Gramatical approach. The shepherd's responsibility in 1 Peter 5: 1-4 is to serve not by force, to serve voluntarily, to serve without seeking personal gain, to serve with enthusiasm and to serve by example.

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Artikel ini membahas tanggung jawab penatua dalam kaitannya dengan penggembalaan terhadap jemaat Tuhan berdasarkan perspektif 1 Petrus 5:1-4.  Secara umum, tanggung jawab gembala adalah memelihara jemaat Tuhan dalam hal kerohanian.  Namun secara khusus Petrus memberikan deskripsi tanggung jawab tersebut  secara terperinci sebagai tugas yang dilakukan tanpa dengan paksa melainkan dengan sukarela, tanpa mencari keuntungan diri sendiri melainkan dengan semangat dan tanpa menggunakan kekuasaan melainkan menjadi teladan.  Artikel ini bertujuan untuk memberikan pemahaman tentang tanggung jawab penggembalaan dalam perspektif 1 Petrus 5:1-4 dan menemukan implikasinya bagi penggembalan pada masa kini.  Metode yang digunakan penelitian ini merupakan metode kualitatif dengan pendekatan Historical Gramatical.  Adapun tanggung jawab gembala di dalam 1 Petrus 5:1-4 adalah melayani tanpa dengan terpaksa, melayani dengan sukarela, melayani tanpa mencari keuntungan pribadi, melayani dengan semangat dan melayani dengan memberi teladan.
Pengembangan Perangkat Pembelajaran Model Problem Based Learning pada Matakuliah Filologi Berbasis Budaya “Aksara Mbojo” untuk Mengembangkan Kreativitas Mahasiswa
Authors: Suryaningsih Lili , Pratama Sandi Achmad
Published: November 2021

Pengembangan pembelajaran yang memanfaatkan model pembelajaran problem based learning. Model pembelajaran yang menekankan pada pengembangan keterampilan berpikir dan penyelesaian masalah. Model Pembelajaran PBL menerapkan pendekatan pemberian masalah autentik pada siswa. Pemberian masalah tersebut, siswa dapat mengumpulkan fakta, mengkonstruksi pengetahuan, menumbuh kembangkan keterampilan berpikir, melatih kemandirian, dan meningkatkan kepercayaan diri. Tahapan Problem Based Learning, yaitu (a) Mengidentifikasi masalah. (b) Mengumpulkan data. (c) Menganalisis data. (d) Memecahkan masalah berdasarkan data yang ada dan analisisnya. (e) Memilih cara untuk memecahkan masalah. (f) Merencanakan penerapan pemecahan masalah. (g) Melakukan ujicoba terhadap rancana yang ditetapkan, dan (h) Melakukan tindakan (action) untuk memecahkan masalah. Sesuai dengan tujuan PBL untuk menumbuhkan sikap ilmiah, dari beberapa bentuk PBL yang dikemukakan para ahli dalam pelaksanaan proses pembelajaran berbasis masalah, siswa dituntut untuk berpikir secara kritis dan ilmiah dalam melaksanakan setiap langkah-langkah pembelajaran berbasis masalah. Untuk memberikan kebebasan kepada siswa untuk berkreasi, ilmiah langkah berpikir dengan mengumpulkan data dari hasil belajar, kemudian siswa dapat menginterpretasikan, menganalisis, dan akhirnya sampai pada kesimpulan. sehingga diharapkan siswa belajar prestasi akan meningkat. Penelitian ini mengembangkan perangkat pembelajaran yang meliputi: Buku teks, RPS, LKS serta instrumen untuk kemampuan berpikir kreatif siswa yang mengacu pada model 4-D (Define, Design, Mengembangkan, dan Deiseminasi). Berdasarkan hasil analisis deskriptif, Model Alat Pembelajaran Khusus matakuliah Filologi "Naskah Aksara" untuk Melatih Kemampuan Berpikir Kreatif Siswa dikategorikan “sangat baik”, ditunjuk oleh terpenuhnya enam kriteria  perangkat pembelajaran yang baik yang meliputi (a) Valid menurut validator, (b) Efektif atas kemampuan Peneliti/Dosen dalam mengelola pembelajaran, (c) Efektif bagi mahasiswa kegiatan dalam pembelajaran, (d) Positif terhadap respon siswa terhadap pembelajaran, (e) Valid, reliabel, dan peka terhadap THB, dan (f) tercapai ketuntasan belajar klasikal.
Misiologi dalam Kisah Para Rasul 13:47 Sebagai Motivasi Penginjilan Masa Kini
Authors: Arifianto Yonatan Alex , Purnama Ferry
Published: November 2021

The concept of saving mankind in God's initiative continues to work to this day. Believers and the church must express the attitude that missionary activities to fulfill the Great Commission are an important part that cannot be separated from the lives of believers and God's church. The church or believers sometimes experience a lack of understanding of the concept of mission so they experience obstacles in evangelizing. The evangelistic motivation that is born from the missiological concept in Acts 13:47 will equip the believer today. The author describes this article using a descriptive qualitative approach, this research can be started with Paul's Call in Evangelism and then text analysis so as to produce findings, among others: first, Preographical and God's Will, Being Light for the Nation and Motivation to Bring the news of salvationKonsep menyelamatkan manusia dalam inisiatif Allah terus bekerja sampai hari ini. Orang percaya dan gereja haraus menyatakan sikap bahwa kegiatan misi untuk memenuhi Amanat Agung merupakan bagian penting yang tidak bisa dipisahkan dari kehidupan orang percaya maupun gereja Tuhan. Gereja atau orang percaya terkadang mengalami ketidak pahaman tentang konsep misi sehingga mengalami rintangan dalam menginjil. Motivasi penginjilan yang lahir dari konsep misiologi dalam Kisah Para Rasul 13:47 akan memperlengkapi orang percaya masa kini. Penulis mendeskripsikan artikel ini dengan menggunakan pendekatan kualitatif deskriptif, penelitian ini dapat dimulai dengan Panggilan  Paulus dalam Penginjilan selanjutnya analisa teks sehingga menghasilkan hasil temuan antara lain: pertama,  Preogratif dan Kehendak Tuhan, Menjadi Terang bagi Bangsa dan Motivasi Membawa kabar keselamatan
HAMAS CHARTER: CHANGES AND PRINCIPLES
Authors: M.A. Adwan Issam
Published: November 2021

The paper examines the differences between the old charter of the Islamic Resistance Movement “Hamas” in 1988 and its political declaration document issued in 2017, titled “Principles and General Policies”. Which redefined the movement and its objectives and vision in concern of Palestine and its main issues, such as Jerusalem and the refugees. In addition, the charter redefined the main regional and international dimensions of the Palestinian cause and the movement’s view of Zionism and Israel, and its position on the Palestine Liberation organization “PLO.” The study was based on in-depth analysis of Hamas-related documents and primary sources. The study is concluded with significant results that signify and highlight some important variables and changes in Hamas’ moderated charter; including, but not limited to, the changes of its objectives, and the use of modern language, best found in the movement redefining itself as a liberation movement.
A PSEUDO-SECULAR SPACE, RELIGIOUS MINORITY AND REASONS FOR EXCLUSION: THE AHMADIYYA MINORITY GROUP IN CONTEMPORARY INDONESIA
Authors: Regus Max
Published: November 2021

This paper examines the intersection of religion and politics and its consequences on religious minorities in Indonesia. This paper is based on a case study of the current position of the Ahmadiyya minority group in the Indonesian Islamic majority. The tension arises from a specific circumstance: This large Muslim country uses democracy as a political system, but the involvement of religious politics is evident. This situation directly endangers the presence of the Ahmadiyya group.
FIQH FOR ACTION: JIHADI SALAFIST AND RETHINKING IN SALAFI JURISPRUDENTIAL FOUNDATIONS
Authors: Evazpour Mehdi , Akvani Hamdallah
Published: November 2021

Albeit sharing “Salafism” in name, Jihadi Salafist movement is different from the mainstream Salafism in multiple respects. Among others, it’s Fiqh (jurisprudence) distinguishes it from other Salfi strands, since Jihadi Salafist established their own underlying fiqh principles. To put it into perspective, their understanding of Salafist jurisprudence principles is characterized by three main features: firstly, it serves collective actions and social agitation; secondly, it excuses its proponents’ autonomous actions: and finally, it theorizes individual instead of institutionalized actions. This study hypothesizes that the Jihadi Salafist movement tends to advance these actions in the light of revisiting the all-important principles of ijtihad, tawhid, iman, tazkya. While complying with official institutes issuing fatwa (religious edict) and dominant social and political order and its gradual amendment is prescribed by Salafism fiqh, Jihadi Salafism demands abiding by Quran and Sunna, and encourages abolishing official institutes in favor of collective and violent actions. The current paper aims to explore Salafists’ atypical understanding of main Salafist theoretical principles and its impact on proceedings and violence in Jihadi Salafist movement.
TO EXIST WITH AND FOR THE PEOPLE: PHILOSOPHICORELIGIOUS ROOTS AND THE NEED OF A MORAL COMMON FAITH
Authors: Jesús Álvarez Álvarez Juan
Published: November 2021

Historical dynamism, moral and religious dimensions, and even the sacral and soteriological sense of our journey through this world can all be found in Judaism. However, it was Christianity which overcame the temporal and national limitations proper to the Old-Testament conception, providing new traits to the idea of a ‘people’. This idea was at the root of political theories (especially, those of Spaniards Vitoria and Suárez) which decisively influenced Modern Age. Nevertheless, it was subsequently transformed and distorted by Liberal and Marxist traditions. Traditions which, however, have shown themselves incapable of building neither the unity needed by peoples, nor the universality to which our nature points, nor the attention demanded of the neediest human beings. Nowadays, to respond to these challenges in a democratic and pluralist environment, it is essential that a moral common faith, structured around a set of objective principles accessible to everybody (but of a Christian inspiration) exists. In the case of politicians, it demands to exist with and for the people.