bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of transient and permanent protein interactions using AI methods
Authors:   Department of Bioinformatics, Central University of South Bihar, Gaya, Bihar-824236, India, Rathore Ravindranath Singh
Published: September 2023

Protein-protein interactions (PPIs) can be classified as permanent or transient interactions based on their stability or lifetime. Understanding the precise details of such protein interactions will pave the way for the discovery of inhibitors and for understanding the nature and function of PPIs. In the present work, 43 relevant physicochemical, geometrical and structural features were calculated for a curated dataset from the literature, comprising of 402 protein-protein complexes of permanent and transient categories, and 5 different Supervised Machine Learning models were developed with Scikit-learn to predict transient and permanent PPI. Additionally, deep learning method with Artificial Neural Network was also performed using Tensor Flow and Keras. Predicted models achieved accuracy ranging from 76.54% to 82.71% and k-NN has achieved the highest accuracy. Detailed analysis of these methods revealed that Interface areas such as Percent interface accessible area, Interface accessible area and Total interface area and the parameters defining the shape of the PPI interface such as Planarity, Eccentricity and Circularity are the most discriminating factors between these two categories. The present method could serve as an effective tool to understand the mechanism of protein association and to predict the transient and permanent interactions, which could supplement the costly and time-consuming experimental techniques.
3′, 4′-dihydroxyflavone ameliorates paclitaxel model of peripheral neuropathy in mice by modulating KATP channel, adenosine (A3) and GABAA (a2 subunit) receptors
Authors:   Department of Pharmacology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education & Research, Chennai – 600116, India, Ramasamy Kavitha
Published: September 2023

Paclitaxel is a widely used cancer chemotherapeutic agent for many solid tumors; but peripheral neuropathy is a major limitation for its clinical use. Studies have demonstrated the usefulness of flavone derivatives in chemotherapy induced peripheral neuropathy. The present study evaluates the anti-neuropathic effect of 3′, 4′-dihydroxyflavone on paclitaxel-induced peripheral neuropathy and the underlying mechanisms. Paclitaxel was administered to mice in a single dose of 10 mg/kg, i.p.The neuropathic behavioural parameters such as mechanical allodynia, cold allodynia and thermal hyperalgesia were assessed 24 h later. The test compound 3′, 4′-dihydroxyflavone (50,100 or 200 mg/kg,s.c) was administered 30 min prior to the assessment of behavioral parameters. The possible mechanisms involving KATP channels, adenosine and GABAA receptors were explored by employing suitable interacting drugs. Molecular docking studies to predict the binding interactions of 3′, 4′-dihydroxyflavone at the above targets were also carried out. The test compound 3′, 4′-dihydroxyflavoneexhibited a significant reduction in paw withdrawal response score in both mechanical and cold allodynia and also increased the tail flick response time in thermal hyperalgesia due to paclitaxel-induced neuropathy. The anti-neuropathic effect of 3′, 4′-dihydroxyflavonewas significantly reversed by pre-treatment with glibenclamide, caffeine or bicuculline revealing the involvement of KATP channels, adenosine and GABAA receptors respectively. Furthermore, the molecular docking studies indicated a favourable binding affinity and good H-bond interaction of 3′, 4′-dihydroxyflavone at these targets. The findings of the present study suggests that, 3′, 4′-dihydroxyflavone has anti-neuropathic effect against paclitaxel-induced peripheral neuropathy through mechanisms that involve KATP channels, adenosine (A3) and GABAA (α2 subunit) receptors.
3D assessment of alveolar bone alterations in orthodontic movement among Indians
Authors:   Department of Orthodontics and Dentofacial Orthopaedics, Patna Dental College and Hospital, Patna, Bihar, India, awaldar Chinmaya
Published: September 2023

Apical root resorption, which is characterised as a biological or abnormal phenomenon that shortens the length of the root apex, is additional typical iatrogenic impact of orthodontic tooth movement that may jeopardise the effectiveness of treatment and tooth lifespan. The main goals of the current retrospective investigation were to assess the dimensions of alveolar bone alterations that come along with orthodontic movement and to look into the frequency and extent of resorption of root in maxillary incisors across categories that were similarly managed with clear aligners (OCA) and fixed appliances (OFA) using CBCT. The study included 50 subjects who were divided into two categories with 25 study subjects in each category. Category OFA: Subjects receiving OFA (n=25). A CBCT scan was used to get three-dimensional pictures at the beginning of therapy as well as at the end of therapy. The overall resorption of root at apical region in OFA group was 0.63ą0.21 mm. The overall resorption of root at apical region in OCA group was 0.32 ą0.36 mm. The difference in observation was statistically significant (p= 0.000) with reduced resorption of root at apical region in clear aligners. It was concluded that the decrease in thickness of alveolar bone was greater in orthodontic fixed appliances group as compared to clear aligners. The resorption of root at apical region was lesser in clear aligners group as compared to fixed appliances.
Marginal bone loss in implant placement among Indian patients with fresh extraction socket
Authors:   Department of Oral & Maxillofacial Surgery, GMC, Saharanpur, India, Sharma Manu
Published: September 2023

It is of interest to examine the Marginal Bone Loss (MBL) around a single titanium implant that was immediately loaded and implanted in a healed or new extraction site in the maxilla over a period of five years. This study involved 36 participants (21 men and 15 women, with an average age of 31 years), all of whom needed to have a single implant placed in the front maxillae. The average marginal bone loss (MBL) in extraction sockets increased by 0.27±0.18 mm after a year, 0.26± 0.17 mm after three years, and 0.21 ±0.18 mm after five years. The mean change in MBL for the group of healed ridges was 0.27± 0.18 mm for one year, 0.22±0.18 mm for three years, and 0.21± 0.17mm for five years. Thus, implants loaded immediately and positioned in either healed ridges or extraction sockets had a similar effect on the local bone.
Effect of promethazine in cleft surgeries among Indian children
Authors:   Department of Oral and Maxillofacial Surgery, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha University, Chennai, India, Sneha Alladi
Published: September 2023

The use of antihistamine therapy in children for the management of upper respiratory tract infections remains a topic of debate. In this study, we focused on evaluating the effectiveness of promethazine (Phenergan), a first-generation H1 receptor antagonist and sedative, in addressing preoperative and intra-operative sequelae in cleft surgeries. A single-centered, parallel, randomized, double-blinded controlled clinical trial was conducted on 128 children aged 2 to 4 years undergoing cleft palate surgery under general anesthesia. The case group received Phenergan syrup orally twice a day for three days, while the control group received a placebo. Primary outcomes measured preoperative anxiety levels using a children's fear scale, while secondary outcomes assessed preoperative sleep quality and cough rate through objective scales. Intraoperative heart rate was monitored using an ECG connected to a monitor. The results demonstrated that the administration of promethazine resulted in a 34% reduction in anxiety levels, a 46% reduction in cold and cough, a 38% improvement in sleep score, and stable heart rates throughout the surgery compared to the control group. Based on these findings, promethazine is considered a safe premedication option for children undergoing cleft palate surgeries; given its benefits outweigh its adverse effects.
Molecular docking analysis of PPARγ with phytochemicals from Moroccan medicinal plants
Authors:   Laboratory of Biology and Health, Faculty of Sciences Ben M’Sik, Hassan II University of    Casablanca,   Morocco, Elkhattabi Lamiae
Published: September 2023

PPARγ agonists play a crucial role in regulating metabolic homeostasis for treating type-2 diabetes (T2D). Due to the adverse side effects associated with thiazolidinediones, a class of PPARγ agonists, there is a growing interest in identifying natural compounds from medicinal plants that have the potential to bind PPARγ. In this study, we extensively investigated Moroccan phytochemicals using computational structure-based screening with the crystal structure of the PPARγ ligand-binding domain (PDB ID: 7awc) to discover novel phytochemicals targeting PPARγ. The docking results of 540 Moroccan phytochemicals were integrated into online databases for further exploitation through in-depth studies. Drug-likeness analysis was performed to assess the phytochemicals drug-like properties. Two promising phytochemicals, 3,4-dicaffeoylquinic acid and Chlorogenic acid, were identified, both exhibiting high docking affinity and unique binding site interactions compared to the established PPARγ full agonist, rosiglitazone. Molecular dynamics simulations of 100 ns were conducted to examine the stability of the complexes formed by both compounds within the PPARγ active site, and their dynamic behavior was compared to the reference structure of PPARγ alone and with rosiglitazone. Binding free energy calculations demonstrated that 3,4-dicaffeoylquinic acid and Chlorogenic acid exhibited higher binding free energy than the reference agonist, suggesting their potential as candidates for experimental validation in future drug discovery efforts targeting PPARγ for the treatment of T2D and metabolic syndrome.
Haematological and biochemical analysis of blood samples from early and late stage breast cancer patients in India
Authors:   4Gene Expression and Signaling Lab, Department of Zoology, Mahatma Gandhi Central University, Motihari, Bihar, India, Jain Buddhi Prakash
Published: September 2023

Breast cancer is the most prevalent cancer with the maximum number of cases worldwide. Early diagnosis of the cancer is necessary for an effective treatment plan. Due to a lack of awareness, diagnosis of breast cancer at an early stage is difficult. The present study aims to evaluate and compare the haematological and biochemical profiles of the early and late-stage breast cancer patient's data records. A retrospective cohort study was conducted on 56 breast cancer patients at the Institute of Medical Sciences, Banaras Hindu University India. Patient data records were obtained and haematological and biochemical parameters were arranged on an Excel sheet and analyzed. Random blood sugar (RBS), alkaline phosphates (ALP) levels, and urea levels were significantly high in patients with late-stage breast cancer (Tumor stage III and IV). At the advanced stage of breast cancer hemoglobin level falls and patients became anemic. Further large-scale studies with a greater number of patient data can help establish these parameters individually or in combination as prognostic and diagnostic markers in breast cancer staging.
Emergent Risk Group-4 (RG-4) Filoviruses: A paradox in progress
Authors:   Division of Infectious Diseases and International Health, Department of Internal Medicine, Morsani College of Medicine, Tampa, Florida 33606. USA, Shapshak Paul
Published: September 2023

Filoviruses, categorized as World Health Organization (WHO) Risk Group 4 (RG-4) pathogens, represent significant global health risks due to their extraordinary virulence. The Filoviridae family encompasses Ebola strains such as Sudan, Zaire, Bundibugyo, Tai Forest (formerly known as Ivory Coast), Reston, and Bombali, in addition to the closely related Marburg and Ravn virus strains. Filoviruses originated from a common ancestor about 10,000 years ago and displayed remarkable consistency in genetic heterogeneity until the 20th century. However, they overcame a genetic bottleneck by mid-century. Paradoxically, this resulted in the emergence of boosted virulent strains from the 1970’s onward. Filovirus research is included in the NIAID Biodefense Program and utilizes the highest level specialized protective laboratories, Biosafety Laboratory (BSL)-4. The spread of Filoviruses as well as other RG-4 pathogens within Africa poses a significant health threat increasingly both in Africa and out of Africa.
Efficacy of LMS for teaching biochemistry to medical students in India during the CoVid-19 pandemic
Authors:   Department of Biochemistry, Sri Devaraj Urs Medical College, Constituent College of Sri Devaraj Urs Academy of Higher Education and Research, Kolar – 563103, Karnataka, India, Munilakshmi U
Published: September 2023

During the pandemic, medical education shifted to online platforms, using the Learning Management System (LMS) for lectures, video recordings, e-resources, and assessments. An inductive qualitative study was conducted among I MBBS students for Biochemistry to assess LMS acceptance and performance. Out of 150 students, 99 responded with 70.7% finding LMS effective, 67.74% agreeing it was user-friendly, and 52.8% satisfied with the grading system. Challenges included internet connectivity, but overall, students' feedback indicated LMS acceptance with academic flexibility, highlighting its potential to enhance medical education, especially during times when e-learning becomes essential.
Gua-Sha therapy on breast engorgement among Indian postnatal mothers
Authors:   Department of Medical Surgical Nursing, Nootan College of Nursing, Sankalchand Patel University, Visnagar, Gujarat-384315, India, Prakash D
Published: September 2023

Many women experience breast engorgement in the first few weeks after giving birth. Breast engorgement that is somewhat severe. It is characterized by full, tense, heated, and tender breasts that are painfully throbbing and aching. Therefore, it is of interest to evaluate the effect of Gua-Sha therapy on breast engorgement in reducing pain among postnatal mothers. A “non-randomized pre-test post-test control group design” was used for this study. “Purposive sampling techniques” were used to obtain 60 postnatal mothers who satisfied the inclusion criteria. Six point engorgement scale and visual analog scale were used for data collection. After pre-test Gua-Sha therapy was given 30 minutes in one cycle twice a day depending on upon the severity. Reassessment was done immediately after the procedure. The result shows that the post test score of breast engorgement in experimental group was 1.1 (± 0.305), where in control group 4.16 (±2.152). The ‘t’ test value of breast engorgement was 9.869. The result shows that Gua-Sha therapy for breast engorgement in reducing pain was significant effect (p <0.05). The study concluded that the Gua-Sha therapy is an effective for reducing breast engorgement and pain among post natal mothers.
Generated heat at implant site during gradual and single-drill protocols among Indian patients
Authors:   Department of Dentistry, Patna medical College, Bihar, India, Sinha Abhishek
Published: September 2023

Excessive heat generation during bone drilling for dental implant placement is a known risk factor for bone necrosis and delayed healing. Therefore, it is of interest to evaluate the maximum change in temperature during and after preparation of the implant site for an implant diameter of 4.2 using gradual drilling and single drilling protocols. Hence, 26 artificial bone blocks with d1 density were divided into two groups where the group I had 13 sites prepared using a single drill and for group II bone blocks, 13 implant sites were prepared with the gradual drill protocol using 5 drills. The drill was done at room temperature with 1500 rpm using constant saline irrigation of 50ml/min. The maximum change in temperature was assessed using an intraoral camera. The data collected were statistically evaluated and results were formulated. Data shows that temperature change was significantly higher in group II where a gradual drill protocol was done compared to group I with a single drill protocol for placing the dental implant of diameter 4.2.Considering its limitations, the present in-vitro assessment concludes that a single drill protocol for preparing an osteotomy site for placing a dental implant of diameter 4.2 generates lesser heat than conventional gradual drilling protocols.
The Influence of Digital Advertising and Word of Mouth on Tourist Visit Interest in Kupang Kelapa Lima Beach
Authors: Ufi Finy , Kefi Darwin , Sayd Imelda
Published: September 2023

This research is entitled "The Effect of Digital Advertising and Word of Mouth on Tourist Visit Interest at Kelapa Lima Beach Kupang". This study aims to determine whether digital advertising and word of mouth promoted by the Kupang City Tourism Office affect the interest of tourist visits to Kupang Kelapa Lima Beach. This research was conducted at Kelapa Lima Beach Kupang. The population in this study was visitors to Kelapa Lima Beach during the data collection period. The sample in this study was taken as many as 50 respondents. The sampling technique used in this study is axial sampling. Data collection techniques using Observation, Interviews, Questionnaires and documentation. The population in this study was visitors to Kupang Lima Coconut Beach. The data analysis technique uses multiple linear regression analysis techniques. The results of this study show that Digital Advertising Variables and Word of Mouth simultaneously have a positive and significant effect on Kujungan Interest in Kelapa Lima Beach Kupang.
Public Procurement Strategy and Performance of Murang’a County Government, Kenya.
Authors: Thiong’o Marion Waceke , Nemuel Arani Wycliffe
Published: September 2023

This study was a cross-sectional study that explored to establish the influence of procurement strategy on performance of County Governments. The guiding specific objectives were strategic sourcing strategy, risk management strategy, negotiation strategy and e-procurement strategy. The theories related to the study were strategic choice theory, principal-agency theory and institutional theory. Further, the study adopted a conceptual framework to show causal relationship between independent and dependent variable. Independent variables are strategic sourcing, procurement planning, contract management and e-procurement which were shown have a causal relationship with the performance of County Governments as the dependent variable. The study adopted descriptive research design. Simple random sampling was adopted to select research participants. A sample size of 85 staff from the county government was sampled randomly using the simple random sampling technique from the total population of staff. The study used both primary and secondary data. The main instrument for data collection was structured questionnaire administered by the researcher. Quantitative data collected was checked for completeness, analysed through statistical analysis for social sciences version 23. Findings of descriptive statistics was presented in form of frequency tables and percentages. A pilot test was conducted before the main study to determine potential weaknesses in the data collection tool through validity and reliability test. The inferential statistics include Pearson’s correlation and regression analysis. The study findings indicated that strategic sourcing strategy, risk management strategy, negotiation strategy and e-procurement strategy have a positive and significant association with the performance of County Governments in Kenya. This implies that public procurement strategy and performance change in the same direction. The study found out that the county government in Kenya have not embraced public procurement strategy for effective performance. Further, the recommendations for improving public procurement strategy include reviewing contracts, enhancing supplier relationship management, conducting pre-screening of suppliers, maintaining compliance with regulations, updating risk management strategies, emphasizing negotiation for fair prices, improving post-negotiation follow-up, and strengthening the integration and security of e-procurement systems. These measures aim to enhance performance, supplier partnerships, efficiency, compliance, risk management, and coordination in the procurement process.
Strategi Menghadapi Persaingan Bisnis Pada UMKM Di Kabupaten Tangerang
Authors: Puji Rahayu  , Joko Supono  , Andri Zalmi
Published: September 2023

The basic knowledge and strategies of microenterprise actors are important to help them manage and develop their businesses more effectively. The following section presents basic knowledge and strategies that may be useful for microentrepreneurs. Knowledge of the concepts, characteristics and challenges facing microenterprises, including resource constraints, access to capital and scale of operations. Understanding the local market, competitors, consumer trends and purchasing behavior can help determine the right marketing strategy. Basic issues of financial management, Hopefully, SWOT analysis can help business stakeholders reassess the internal and external factors of the business.
Strategi Pemasaran Online dan Pencegahan Penipuan Eradigitalisai
Authors: Dyas Yudi Priyanggodo  , Endaria Endaria  , Dedy Alamsyah
Published: September 2023

Online marketing, also known as digital marketing, involves promoting products or services through digital mediums such as the Internet, mobile devices, and social platforms. It involves using different strategies to achieve business goals, such as increasing brand awareness, generating leads or customers, increasing sales, and building relationships. customer system. Phishing is a technique in which scammers attempt to trick victims into providing personal information such as passwords, credit card numbers, or other financial information by pretending to be a trustworthy organization through fake email or fake website.
Dampak Lingkungan Stunting Dan Perekonomian
Authors: Rully Angraeni Safitri  , Dewi Puspitasari  , Fajar Ramadhan Saputra
Published: September 2023

Stunting is complex and involves various factors such as access to nutritious food, feeding practices, sanitation, maternal and child health care, family economics, and the physical environment. To overcome stunting and its impacts, a cross-sectoral approach is needed which includes improving access to nutritious food, improving sanitation, health education, access. The community service program is carried out with a community approach, so that it is right on target. The method used in this community service is community service with a community service method, combining the essence and practical analysis of many things, scientifically accurate and authentic sources. This can reduce a country's labor capacity and hinder long-term economic growth. Limited education can limit their access to better, higher-paying jobs in the future
Negotiations on Subjective Interactions between Teaching and Learning in Remote Education
Authors: LIU RUIQI
Published: September 2023

With the development of science and technology, the gradually developed self-media and various learning platforms provide people with a variety of learning methods and ways to contact other cultures and exchange ideas, which makes people's lives more convenient. Because on the one hand, online learning makes learners lack opportunities for offline interaction and real-time communication, and thus lacks self-motivation. Remote education has gradually become a common way of learning, especially after the outbreak of the new crown epidemic, distance education has become an important way for many learners to acquire knowledge. If technology and culture are regarded as two subjects in a complex system, or two interactive symbols, there are many conceivable research points for the research on teaching and learning in distance education.
सांस्कृतिक राष्ट्रवाद की अवधारणा एवं राष्ट्रीय स्वयं सेवक संघ
Authors: सिंह एम पी , सिंह* रमाकान्त
Published: September 2023

भारत में सांस्कृतिक राष्ट्रवाद की अवधारणा इतिहास के प्रारम्भ से ही दिखाई देती है। वस्तुतः इसे भारतीय आत्मा को सन्दर्भित करने वाला प्रत्यय माना जा सकता है। प्राचीन कालीन साहित्य में इस प्रकार के स्वर अनेक स्थानों पर प्राप्त होते है। भारत की एक निश्चित सीमाओं का उल्लेख करते हुए उसकी सन्तति को भारती कहना तथा विभिन्न प्रकार की भिन्नताओं के मध्य एक समान अनुप्राणित करने वाली भावनाओं के रुप में इसकों देखा जा सकता है। वर्तमान काल में इस अवधारणा के राजनीतिक, सामाजिक एवं धार्मिक पहलुओं पर अधिक जोर दिया जाने लगा है, जिसके कारण एक विशेष बौद्धिक वर्ग के द्वारा इसे हिन्दू संस्कृति से जोड कर देखा जाने लगा है। वास्तविकता यह है कि सांस्कृतिक राष्ट्रवाद को राष्ट्रवाद के एक प्रकार के रुप में देखे जाने की आवश्यकता है, जिसका किसी धर्म अथवा संप्रदाय से कोई सम्बन्ध नहीं रहा है। यह मानवता के उच्चतम शिखर के उद्घोष के रुप में देखा जाना चाहिए। इस अवधारणा में धर्म, संप्रदाय, भाषा, जाति, प्रदेश इत्यादि के रुप में किसी प्रकार के विभाजन का कोई प्रमाण नहीं मिलता है। राष्ट्रीय स्वयं सेवक संघ भारतीय संस्कृति पर आधारित इस प्रकार के राष्ट्रवाद को अपने उद्भव काल से ही प्रश्रय देती रही है तथा इसे राष्ट्रीय उत्थान के महत्वपूर्ण कारक के रुप में स्वीकार करती है।
संस्कृत वांग्मय में सर्वजनहित की भावना
Authors: माथुर रिचा , त्रिपाठी अभिषेक दत्त
Published: September 2023

संस्कृत वांग्मय में सभी जीव , जन के हित की भावना प्रकट होती है वैदिक वांग्मय में तो सर्वजनहित के लिए प्राचीनकाल से भारतीय धरातल पर प्रणीत वेद वांग्मय धरती पर मानवमूल्यों की सुदृढ़ आधारशिला रख चुका है जिसके आधार पर हमारी भव्य संस्कृति की अट्टालिका अपनी पूर्ण गरिमा के साथ खड़ी है हमारे चारों वेद , एक सौ आठ उपनिषद , नाटक महाकाव्य एतिहासिक काव्य मनुष्य को अपने गंतव्य की ओर इस तत्परता के साथ अग्रसर होने की प्रेरणा देते है कि उससे कही भी कोई भी त्रुटि न हो जाये। मानव जीवन हित के लिए आचरणीय सूत्रों को स्वीकार कर उस पर चलने की आवश्यकता है इन आचरणीय सूत्रों के समाहार स्वरूप के अन्तर्गत धर्माचरण, परोपकार, दानशीलता, सत्य वचन, निष्काम सेवा, त्याग, शांति अहिंसा, सौहार्द्र भावना इत्यादि आते है इन सभी का वर्णन सम्पूर्ण संस्कृत वांग्मय में कई शताब्दियों पूर्व हुआ है इन सभी के अभाव में मनुष्य का जीवन एक बंजर भूमि के समान है। इन सभी को मानव अपने जीवन में अपनाकर जीवन को सार्थक बना सकता है-

               हरिः ऊँ पूर्णमदः पूर्णमिदं पूर्णात् पूर्णमुदच्यते ‘

                पूर्णस्य पूर्ण मादाय पूर्णमेवाव शिष्यते ”
Problems of Unorganized Workers
Authors: Pandey Mukesh Kumar , Gupta* Pooja
Published: September 2023

Despite their significant contribution to the economy, only 6 % of unorganized workers avail any type of social security support. The growth of real wages of casual workers has also been relatively slow in the post-reform period. The workers of the unorganized sectors are the worst affected in the event of any kind of crisis. The fundamental socio-economic rights of domestic migrant workers were adversely affected during the lockdown, but the state response was not up to the expectation. Despite expansion in policy and programmes, India`s wage and social security system is quite vulnerable to unorganized workers. The people of our country know how to arrange the means of subsistence on their own, but if they get adequate government sponsored social assistance easily at the right time, then the difficulties related to their life will be greatly reduced.
Colonial Power and Native Resistance: A Cinematic Study of James Cameron’s Avatar
Authors: Mishra Santosh Kumar
Published: September 2023

Colonial powers have the history of destroying native civilizations to suit their own ends. They do it either by psychological persuasion or by military force. They often come, pretending as messiah but later becomes a curse for the nations and cultures. This multidimensional exploitation also leads to strong resistance from the native people, often living their Utopian dream and believing in their culture, they have courage and conviction but not the resources to match their adversaries. Colonial powers seek methods to learn and observe the native way of living thereafter they manipulate the minds of natives to gain supremacy of several kinds.  Cinema is known to have always mirrored, the truth, no matter how much uncomfortable it may look to some people. The great movie ‘Avatar’ by James Cameron is allegory of such colonial oppression. The present paper analysis how effectively Cinema has brought the native resistance and struggle of the colored people against the colonial oppression to the fore and has given voice and platform to the speechless subalterns.
FORMAÇÃO AMBIENTAL E O DESENVOLVIMENTO SUSTENTÁVEL
Authors: Vicente Claudinei Sérgio , Vicente Melissa Wendy Ribeiro
Published: September 2023

O trabalho tem por objetivo abordar as discussões sobre a temática da educação ambiental, relacionar a questão econômica com o desenvolvimento sustentável, vinculadas ao propósito da institucionalização das propostas e diretrizes curriculares nacionais para a educação ambiental e as suas repercussões no contexto social. Tem como finalidade a disseminação da cultura escolar, destacando um compromisso ético, político e proporcionando melhor qualidade de vida para sociedade perante os profissionais que exercem as atividades críticas relacionadas ao meio ambiente. Destacamos a importância da transformação da natureza e os requisitos para garantirmos uma vida saudável e sustentável, visando o bem individual e coletivo. Salientamos a forma que a sociedade vem se desenvolvendo no passar dos anos, o desenvolvimento das pesquisas e as transformações naturais que foram se ampliando relativamente com o tempo, levando as considerações pertinentes quanto a nossa compreensão como ser e de como estamos envolvidos com o meio ambiente. Este intercâmbio de saberes e compreensão é o ponto importante para nossa sobrevivência, um instrumento transformador que estabelece sincronia entre o homem e a natureza.
TRABALHO, ADOECIMENTO, VOLTA E READAPTAÇÃO DO TRABALHADOR
Authors: Lima Moara Ludmila Rosa , Bacelar Winston Kleiber De Almeida , Fernandes Priscila Castro Cordeiro , Oliveira Thiago Rodrigues
Published: September 2023

As dimensões contraditórias do trabalho, o sofrimento humano nas organizações e as relações de trabalho são frequentemente estudadas. O ser social que antes era transformado pelo trabalho, hoje adoece e se torna vítima do próprio labor e dos vieses do modo de produção capitalista. Por meio de revisão da literatura e análise crítica de publicações buscamos refletir sobre o processo de reabilitação no Brasil, desde seu histórico e construção até a forma como é aplicado hoje. Com isso, buscamos compreender se o processo de reabilitação cumpre a sua finalidade de reinserção do indivíduo de maneira plena.
ANÁLISE DA DISTRIBUIÇÃO ESPACIAL E DA TAXA DE DETECÇÃO DOS CASOS DE HIV/AIDS NO NORDESTE BRASILEIRO
Authors: Neto Antonio Domingos de Sousa , Reis Marijany da Silva
Published: September 2023

Este estudo analisa a distribuição espacial e a taxa de detecção dos casos de HIV/Aids no Nordeste brasileiro. Trata-se de um estudo descritivo, a partir dos dados secundários de casos notificados de HIV/Aids, no período de 2002 a 2021, na região Nordeste do Brasil. Observou-se que houve uma maior prevalência em pessoas do sexo masculino, tendo um aumento entre os anos de 2017 a 2021. A faixa etária de indivíduos entre 20 e 49 anos e aqueles que possuem ensino fundamental incompleto estão com maior proporção no número de casos em relação as suas variáveis equivalentes. O estado do Pernambuco manteve constância nos números de casos no decorrer dos anos. A quantidade de casos entre o sexo masculino se manteve alta em relação ao feminino. Notou-se que Pernambuco, Maranhão, Alagoas e Rio Grande do Norte, mantiveram altos índices de casos na distribuição da taxa de incidência do HIV. Em relação à orientação sexual, quando alocados os sexos, sobressaem-se os autodeclarados heterossexuais. Destaca-se a importância deste estudo em suas possíveis contribuições para o desenvolvimento de modelos de prevenção, reforço de campanhas e políticas públicas com enfoque nas áreas de risco do HIV na região Nordeste.
DIREITO COLETIVO DO TRABALHO: ESTUDO DE CASO CONVENÇÃO COLETIVA DOS EMPREGADOS DO COMÉRCIO DO ESTADO DO TOCANTINS
Authors: Xavier Jessika Mayara Resplande , Carvalho Filho Gilson Ribeiro
Published: September 2023

As Convenções Coletivas nasceram e se desenvolveram na Europa Ocidental e nos Estados Unidos, evoluindo na legislação brasileira como fruto da luta operária e também pela influência exercida por diversos países industrializados que ao difundirem os instrumentos de negociação coletiva mostraram ser uma opção vantajosa para trabalhadores, empregadores e Estado. Esse artigo apresenta o direito coletivo do trabalho, concretizado por meio das Convenções Coletivas, como um mecanismo que veio para regular os interesses em comum dos trabalhadores. Portanto, pretende-se com essa pesquisa analisar a Convenção Coletiva de Trabalho do Sindicato dos Empregados no Comércio em todo o Estado do Tocantins, 2021/2023, procurando sempre correlata às especificações deste instrumento a legislação vigente.
UM OLHAR SOBRE INSEGURANÇA E MEDO EM PEQUENAS E MÉDIAS CIDADES
Authors: Garcia Gustavo Gabriel , da Silva Henrique Manoel
Published: September 2023

Nos últimos anos, tem sido evidente um substancial aumento da criminalidade em cidades de porte médio e pequeno no Brasil. O que uma vez foi uma realidade mais prevalente em áreas urbanas de grande escala, agora se expandiu para atingir comunidades de diversos tamanhos. O presente estudo tem como propósito oferecer contribuições teóricas que lançam luz sobre esse fenômeno preocupante. A intenção subjacente é estimular futuras pesquisas nessa temática particularmente sensível, promovendo assim uma compreensão mais profunda e uma abordagem mais eficaz para enfrentar esse desafio crescente.
Book Review - Making the move to K–12 online teaching: Research-based strategies and practices
Authors: Adelstein David
Published: September 2023

Making the move to K–12 online teaching: Research-based strategies and practices
Interview with Eddie Reisch
Authors: Owen Hazel
Published: September 2023

Eddie Reisch is currently working as a policy advisor for Te Reo Māori Operational Policy within the Student Achievement group with the Ministry of Education in New Zealand, where he has implemented and led a range of e-learning initiatives and developments, particularly the Virtual Learning Network (VLN). He is regarded as one of the leading innovators in the area of blended learning in K–12, and during his 30 years in education he has applied an unwavering belief that all learners can be the best they can when empowered to collaborate, make choices, be creative, and learn from their mistakes.Eddie was interviewed by Hazel Owen, Director of Ethos Consultancy NZ on 10 January 2013.
impact of physical exercise on the mental health of the elderly
Authors: Ajmiri Mohammad Younus , Bahir Hizbullah
Published: September 2023

Objective. To study the impact of physical exercise on the mental health of the elderly, and to formulate corresponding management strategies for physical exercise. Methods. From February 2018 to February 2019, 180 elderly people were selected from the community as research subjects. The elderly people included in the group were randomly divided into a physical exercise group and a control group, and the symptom self-rating scales of the two groups were compared. (SCL-90) score. Results. The scores of somatizations, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, and terror of the elderly in the physical exercise group were significantly lower than those in the control group (p < . 05); there was no significant difference in the scores of hostilities, paranoia, and psychosis between the two groups (p > .05). Conclusion. The mental health of the elderly is an important factor affecting their quality of life, and strengthening the way and content of physical exercise for the elderly can effectively regulate the mental health of the elderly, thereby promoting the improvement of their quality of life and, to a certain extent, alleviating the social and social problems brought about by population aging. Economic pressure is of great significance to the long-term and stable development of society.
Relative age effect
Authors: Rossing Niels Nygaard , Pedersen Kasper Raaby , Ryom Knud , Hancock David J.
Published: September 2023

The aim of this study was to examine relative age effect (RAE) on distinctive variables and age groups in recreational football. Participants (N = 79,249) included male (n = 63,540) and female (n = 15,709) players aged 2 to 12 years. Data were gathered through an official database containing all licensed players in Denmark. Birthdate distributions were split by age category, sex, club size, year group size, and birth quarter (Q1 = January to March, Q4 = October to December). RAEs were calculated using chi-square analysis. Significant RAEs existed in all age categories (except females in U6 and below). The effect was most pronounced at the entry level among both males and females. Club size was not associated with RAEs, but were shown in smaller and midsized year groups, but were absent in larger year groups. The results of this study show that RAEs are present from early sport participation.
Parents as learning facilitators
Authors: Dannesboe Karen Ida
Published: September 2023

This paper examines the implications of various learning-centred initiatives for the relationship between early childhood education and care (ECEC) institutions and families in Denmark. Since the 1990s, promoting early learning has been a key objective for Danish ECEC institutions, reshaping the Danish social pedagogy tradition. Recently, early learning initiatives have become part of the collaboration with parents on so-called home learning. Based on ethnographic studies of such collaboration, I argue that the expansion of dominant early learning agendas from ECEC to families results in an institutionalisation of parenthood. The analysis shows that parents are expected to embrace a learning agenda promoted by ECEC professionals. They are appointed as learning facilitators who must strive to support early learning at home and improve their parenting skills. Furthermore, parents’ engagement in early learning is intertwined with the practical organisation of family life and with ideals of a good family and a good childhood.
Instilling Care
Authors: Xuan Li
Published: September 2023

This paper explores the concept of care as a socialisation goal for school-age children among contemporary Chinese parents. Data was generated from interviews with parents from rural and urban families in Nanjing, China in 2011– 2012. Parents’ spontaneous remarks on care revealed how today’s Chinese parents highlighted childcare as parental responsibilities, cultivated children’s self-care skills, and promoted children’s other-caring qualities. In so doing, parents attempted to motivate concurrent and future elder care, improve children’s social competence, and inspire altruistic other-care in their children. Although Chinese parents’ imagination of care is largely centralised within the family due to sociocultural contexts such as the culture of intensive parenthood, China’s care deficiency in a neoliberal economy, and the One-Child Policy, Chinese parents also aspired instilling other-caring qualities in their children.
Genetic determinism
Authors: Bach Dil
Published: September 2023

Based on fieldwork in families and a mainstream kindergarten in Denmark, this article discusses how children who are viewed as special and at risk are subjected in new ways to “concerted cultivation” between childhood professionals and parents. The article identifies two forms of parental determinism that are associated with two different views of the good parent: On the one hand, psychologically inspired parental determinism focusing on what parents do; on the other, genetic determinism focusing on who parents are biologically. Genetic determinism dominates the empirical material, suggesting an increasing influence from psychiatry in how parents understand children’s development. This implies that the natural and the cultural interact in new ways and transforms the collaboration between parents and professionals, creating new expectations on both sides. As a result, parenting at-risk children is characterized by less trust in intuition and a greater need for guidance in order to accommodate the child’s special nature.
Parenting in the Courtyard
Authors: Martiny-Bruun Asger
Published: September 2023

This article investigates the challenges faced by parents raising children in stigmatised neighbourhoods based on eight-month ethnographic fieldwork. By exploring parenting practices within the public spaces of local communities, the study reveals the intricate interplay between moral considerations, daily practices, and social interactions. It demonstrates the association between parenting practices and not only the parents’ social status and belonging but also the perceived respectability of the neighbourhood. Examining parents' efforts to ensure their children's safety and foster their independence, this study uncovers the diverse norms that shape parents' agency and community integration. Thereby, it highlights the tensions parents face in maintaining the community's social respectability while challenging prevailing notions of territorial determinism. These insights contribute to a deeper understanding of the complexities surrounding parenting in stigmatised neighbourhoods, emphasising the need for contextualised approaches to understanding the social dynamics and morality of parenting in these communities.
Efficiency of Health Care in the EU28 Countries with the Innovation Factor Taken Into Account
Authors:   University of Warsaw, Faculty of Management, Zalewska Mariola
Published: September 2023

The article presents an attempt to analyse the efficiency of health care systems in sub-regions of Poland in comparison to sub-regions of EU countries, using the indicator of average life expectancy and an innovation indicator developed on the basis of the European Innovation Scoreboard. The basic source of data presented in the article is commonly available data from databases of countries or international organisations: the Polish Central Statistical Office (GUS), Eurostat, WHO. Comparative methods were applied to the following indicators: the expenditure on health care, life expectancy and innovation at the country level. Life expectancy depends mainly on health expenditure, but also on access to innovative therapies. Countries referred to as “modest innovators”, to which Poland belongs, have a lower indicator of life expectancy than innovation leaders. Innovation is becoming the main engine of progress in health care.
Financial Consequences of the Act on Reimbursement of Medicines for the National Health Fund and Patients
Authors:   Warsaw University, Faculty of Management, Skrzypczak Zofia , Suchecka Jadwiga ,   Medical University of Lodz, Faculty of Health Sciences, Department of Medical Insurance and Health Care Financing
Published: September 2023

The aim of the paper is to present the financial consequences of the entry into force of the Reimbursement Act in 2012 for the National Health Fund, a payer of public funds, and for individual patients. A greater burden on the society – i.e. an increase in the level of co-payment for medicines – turns out to be integrated in the general tendency that emerges durin
Individual and Institutional Implications of Building a Smoke-Free Society
Authors:   University of Warsaw, Faculty of Management, Król Grzegorz
Published: September 2023

Cigarette smoking is the cause of more premature deaths than traffic accidents, AIDS, other drugs, alcohol, homicide and suicide taken jointly. Eliminating smoking would curb the cost of reduced employee productivity, smokers’ treatment and premature mortality. It would seem, therefore, that it is in the interest of the society, employers and addicted individuals to free the world from smoking. At the same time, Poland is among the largest tobacco producers in Europe, and the sale of tobacco products is a source of significant state budget revenues. Health, social and economic losses resulting from the harms of smoking are contrasted with the potential economic and budgetary losses, and the inevitability of the emergence of a shadow economy if tobacco products were to be delegalized. Current social, medical and legal measures aimed at the reduction of tobacco consumption do not have the desired effect and require a radical change in approach. It is not nicotine that kills smokers, but tar created in the process of burning tobacco leaves. Replacing highly harmful tobacco smoking with nicotine delivery products, which are safer by an order of magnitude, is presently the most viable way to improve public health and the quality of life of people addicted to nicotine.
Case Study: Analysis of the Entry Into Force of the Law on the So-Called Hospital Network and Its Consequences for Further Activity of Dr. Wadiusz Kiesz Cardiology and Angiology Center, American Heart of Poland (AHP) in Starachowice
Authors:   Jagiellonian University, Faculty of Health Sciences, Medical College in Krakow, Department of Health Policy and Management, Institute of Public Health, Rogala Maciej , Dzik Grzegorz ,   Dr Wadiusz Kiesz Cardiology and Angiology Center, American Heart of Poland (AHP) in Starachowice; American Heart of Poland (AHP) in Nysa, Cardiology and Angiology Center, Donesch-Jeżo Ewa
Published: September 2023

The aim of the article is to analyze the impact of the introduced systemic change in the health care sector. The case study of a hospital unit in the field of cardiology and vascular surgery analyzes the indirect and direct effects of the implementation of the change in the health care system in the form of the Act of 23 March 2017. The paper describes and assesses the factors that led to the creation, development and liquidation of the Department of Cardiology and Vascular Surgery, which operated as part of Dr Wadiusz Kiesz Cardiology-Angiology Center, American Heart of Poland (AHP) in Starachowice. The study also carried out an analysis of the effects of the depletion of the medical base on patients previously treated in AHP in Starachowice in the field of cardiology and vascular surgery in this area.
Data Mining Process Maturity – Result of Empirical Research
Authors:   University of Gdańsk, Faculty of Management, Institute of Organisation and Management, Sliż Piotr
Published: September 2023

The main goal of the article is to present the results of the study relating to the assessment of data mining process maturity on the example of Polish organizations. Several partial objectives were added to the main goal. CT1: To diagnose the current state of knowledge regarding the data-mining process in the discipline of management sciences. Attempts at attaining this objective served to identify the knowledge gap. CT2: To adopt an appropriate theoretical perspective in the form of a theoretical model, enabling the implementation of future research challenges. The first section of the article describes the results of quantitative and qualitative bibliometric analysis. The second section presents the parameters and the definition of the data mining process. Then, the theoretical model used for measuring the maturity of the data mining process is discussed. In the fourth section, the structure of the empirical research conducted and its partial results are outlined. It transpired that the vast majority of the surveyed organizations qualified at the first level of process maturity, defined as a state in which organizations are not aware of the need to identify activities aimed at data mining. Research objectives formulated in the article have been implemented using such research methods as quantitative and qualitative bibliometric analysis, opinion polls and statistical methods.