bluuebunny/crossref_metadata_2025 huggingface dataset:
13С urease breath test as a method for Helicobacter pylori infection control in case of using
traditional and alternative eradication techniques
Authors: Rapoport S. I. , Shubina Nina A.
Published: November 2020

Helicobacter pylori infection is one of the main factors responsible for gastrointestinal disorders; it can either cause a disease by itself or accentuate its clinical manifestations. Eradication of H. pylori eliminates dyspepsia completely or decreases its severity. There are reliable analytical methods to monitor infection including 13С urease breath test. Traditional antibiotic the even if alternative approaches may be equally successful.
The role of orthostatic circulatory changes in the development of vascular disorders.
Authors: Dorogovtsev Viktor N. , Grechko A. V.
Published: November 2020

The aim of this review is to estimate contribution of orthostatic circulatory changes to the development of vascular disorders. In the XXI century, the cardiovascular disorders remain a most widespread pathology responsible for the high mortality and disablement rate throughout the world. Their main risk factors have been identified, but the influence of gravity on the cardiovascular system is usually disregarded even though it exerts an appreciable effect of special importance for neurohormonal regulation. Disturbed regulation of orthostatic changes in circulation manifest as orthostatic arterial hypertension is a well known risk factor of cardiovascular pathology. The review is focused on orthostatic circulatory disorders and cause-and-effect relationships between certain risk factors in pathogenesis of these conditions.
Impact of comorbidities on myocardial remodeling and dysfunction in heart failure with preserved ejection fraction.
Authors: Kamyshnikova Lyudmila А. , Efremova O. A.
Published: November 2020

Aim. The generalization of the modern data on the influence of comorbidities on cardiac remodeling and heart dysfunction in chronic heart failure (CHF) with preserved ejection fraction (EF). The objectives of the study included the analysis of the pathogenesis of CHF with preserved ejection fraction. Material and methods. Analyzed all Russian and English literature, submitted to the search engines. Results. Analysis of scientific literature showed that the increase in systemic vascular inflammation, endothelial dysfunction and oxidative stress lead to reduced bioavailability of nitric oxide , which leads to increased stiffness of the left ventricle and adverse remodeling of the heart in CHF with preserved ejection fraction. Comorbidities such as overweight /obesity, diabetes, hypertension, chronic obstructive pulmonary disease, anaemia and chronic renal dysfunction leads to coronary remodeling in microvascular endothelial inflammation. The negative contribution is also made by demographic factors such as older age and female gender. In the present review substantiates the crucial role of comorbidities in the pathophysiology of CHF with preserved ejection fraction. Conclusion. Summarizing the analysis of literature sources, devoted to the pathogenesis of CHF with comorbidity, the findings that, in addition to diastolic dysfunction of the left ventricle, there are other patofiziologiia mechanisms: the violation of backup functions, the violation of jeludochno-blood relationship, the energy deficit of the myocardium, pulmonary hypertension, chronotropic imbalance, inflammation, oxidative stress and endothelial dysfunction. With CHF with preserved ejection fraction comorbidities contribute to systemic inflammation which causes oxidative stress in the coronary microvascular endothelium. This reduces the bioavailability of nitric oxide in the myocardium and leads to reduced activity of protein kinase G in cardiomyocytes, which therefore become stiff and hypertrophied. In addition, with increasing age and postmenopausal hormonal changes may lead to additional structural and functional changes.
Esophageal manometry high-resolution in
clinical practice.
Authors: Maev I. V. , Barkalova E. V. , Hovsepyan M. A. , Kucheryavy Yu. A. , Andreyev Dmitry N.
Published: November 2020

At present, esophageal manometry high-resolution (high resolution manometry, HRM) is a highly informative and promising method for diagnosing patients with different disorders of the motor function of the thoracic esophagus and disorders of tone of the sphincter apparatus. This article presents a series of observations that demonstrate the diagnostic capabilities of the methodology in current clinical practice.
Acute hepatic lesion associated with myocardial infarction: clinical significance and modern diagnostics
Authors: Il’ina Anastasiya S. , Borovkova N. Yu. , Spassky A. A. , Borovkov N. N.
Published: November 2020

This review of the literature is devoted to the problem of acute kidney injury (AKI) in patients with acute myocardial infarction (MI). We discuss the occurrence of AKI in patients with MI, mechanisms of its development and modern diagnostic methods. The article examines biomarkers of kidney injury that may be useful for early diagnostics of AKI.
Zika fever: clinical, epidemiological, laboratory, and diagnostic aspects
Authors: Zhdanov K. V. , Zakharenko S. M. , Kovalenko Aleksandr N. , Semenov A. V. , Kozlov S. S. , Fisun A. Ya.
Published: November 2020

The authors overview data on the prevalence of Zika fever with reference to biological properties of the causative agent, epidemiological process, pathogenesis, and clinical symptoms of the disease. Special attention is given to the identification of the virus in pregnant women, microcephaly in the babies born by Zika-infected women, algorithm of laboratory diagnostics, and measures needed to prevent and control mosquitoes that spread viruses.
The effectiveness of piribedil for the treatment of cognitive disorders in patients with coronary heart disease: results of six-month
observation
Authors: Petrova M. M. , Prokopenko S. V. , Eremina O. V. , Mozhejko E. Yu. , Kaskaeva D. S. , Gankin M. I. , Shevchenko O. I.
Published: November 2020

Aim. The detection of cognitive deficiency after heart bypass surgery, the evaluation of the influence of piribedil on the higher cerebral function in the early postoperative period during the follow-up. Materials and methods. 64 patients with ischemic heart disease were examined. They were divided into two groups. Patients of the main group (n=32) were treated with pronoran (piribedil) at a daily dose of 50 mg for 3 months. 32 patients of the control group received standard therapy in the postoperative period. All patients had undergone heart bypass surgery. Cognitive functions were examined before operation, 10 days , three and six months after surgery. Results. Positive dynamics of all tested parameters was documented in the patients of the main group within 6 months after the onset of therapy. In control patients, cognitive disorders remained at the preoperative level based on the results of three tests. Conclusion. The positive results of piribedil therapy suggest that piribedil has positive effect on memory, attention and psychomotor activity of the patients
Arterial hypertension: Modern problems
Authors: Bokarev Igor N. , Dulin P. A. , Ovchinnikov Yu. V. , Simonenko V. B.
Published: November 2020

Arterial hypertension (AH) is one of the most common diseases. Despite numerous studies, many problems related to this pathology remain to be elucidated. The modern classifications of AHare contradictory and true causes of elevated blood pressure (BP) are unknown. There are no methods for diagnostics of early stages of AH nor is there adequateunderstanding of what hypertensive crises are, how they are to be classified and why they develop. Pathomorphosis of AH is practically unexplored. There are no efficient medications and therapies for the radical treatment of AH. The authors propose classification of hypertensive crisis, hypertensive disease, and symptomatic AH. It is recommended to use 24-hour blood pressure monitoring in all AH patients. New approaches to diagnostics of early stages of AH are proposed.
Genderspecific differences of homocysteinemia and its influence on oxidative stress parameters and endothelial function in patients with stable forms of coronary heart disease
Authors: Belaya Olga L. , Bondar K. Yu. , Markova L. I. , Kuropteva Z. V. , Baider L. M. , Mikhailova I. S. , Kuznetsova Yu. V.
Published: November 2020

One of the early manifestations of atherosclerotic lesions is endothelial dysfunction developing under conditions of reduced nitric oxide production, hyperhomocysteinemia, and oxidative stress. Bearing in mind high interest shown to gender-specific peculiarities of cardiovascular diseases, it appears important to study the relationship between these features in men and women with stable forms of coronary heart disease (CHD). Material and methods. The study included 102 patients with sable COPD divided into 2 groups (men and women) and 40 practically healthy subjects. Plasma homocysteine levels were measured by high-resolution gas-liquid chromatography with fluorescent detector with the use of Eko-Novo Milikhrom A-02 apparatus (Russia). Standard methods were used to measure plasma lipids, products of their peroxidation (dienic conjugates and products reacting with 2-thibarbituric acid), antioxidant enzymes (glutathioneperoxidase, and superoxide dismutase in erythrocytes), activity of the ceruloplasmin-transferrin system (by electron paramagnetic resonance method), final metabolites of nitric oxide using the Gries reaction. The endothelial function was studies by ultrasound with the evaluation of endothelium-dependent vasodilation. Results. The mean levels of homocystein and final NO metabolites in men with stable CHD were 1.5 times higher (р=0,01) and 12% lower (р = 0,03) than in women. Endothelial dysfunction was more pronounced in men (р< 0,05). Conclusion. Patients with CHD exhibit significant gender-specific differences in blood levels of of homocystein and final NO metabolites as well as in endothelium-dependent vasoreactivity associated with intensification of lipid peroxidation and impairment of antioxidative protection.
Combination of
omega-3 polyunsaturated fatty acids and statins for the prevention of atrial fibrillation after coronary bypass surgery
Authors: Rubanenko Olesya A. , Fatenkov O. V. , Khokhlunov S. M. , Semagin A. P. , Kuznetsov D. V. , Limareva L. V.
Published: November 2020

Aim. To evaluate the influence of combination of omega-3 polyunsaturated fatty acids and atorvastatin on the risk of atrial fibrillation (AF) after coronary bypass surgery (CBS). Material and methods. The study included 114 patients divided into 2 groups, one comprised of 59 ones (75,6% men of mean age 62,0±7,3 yr given conventional medication), the other including 55 patients (80,0% men of mean age 59,4±6,7 yr given omega-3 polyunsaturated fatty acids 5 days before (2 g/d) and during 3 weeks after CBS (1 g/d)). All patients were treated with atorvastatin at the outpatient stage. IL-6,8, 10 and C-reactive protein (CRP), fibrinogen, troponin, NT-proBNP, superoxide dismutase (SOD), and myeloperoxidase were measured at admittance and on day 3.7±1.4 after surgery. Results. AF developed on day 5.9±4.9 (mean) after surgery. Patients of group 2 tended to have fewer new episodes of arrhythmia although no significant difference between the groups was documented (9,1% vs 18,6%, р=0,12). Group 2 included more smokers (74,5% vs 45,8%, р=0,002) and patients with atherosclerosis of lower limb arteries (87,3% vs 71,2%, р=0,03) but fewer those consuming nitrates (39,0% vs 18,2%, р=0,01) and Ca antagonists (45,8% vs 21,8%, р=0,006).Mean dose of atorvastatin given to patients of groups 1 and 2 was 24.7±12.5 and 25.1±10.5 mg/d respectively (р=0,2), duration of its intake 14.6±12.7 and 21.5±19.3 months (р<0,001). There. was no significant difference between leukocyte count, leukogram, IL-8, IL-10, NT-proBNP, and troponin levels before and after CBS. Surgical myocardial revascularization caused a rise in leukocyte count, shifted the leukogram toward predominance of stab and segmented cells, increased IL-8, IL-10, fibrinogen, NT-proBNP, CRP, and troponin levels in both groups. IL-8 and IL-10 levels remained normal before and after surgery. Preoperative IL-6 level in group 1 was significantly higher than in group 2 (21,7±13,0 vs 2.5±2,2 pg/ml, р<0,001). Postoperatively, the difference was absent. The CRP level before surgery was high in both groups (3122.7±2175.8 vs 3670.8±2490.0 U/g) but decreased after CBS although remained higher in group 1 (1957.6±1660.3 vs 1069.8±630.2 U/g, р<0,001). Myeloperoxidase level increased postoperatively in both groups but the difference was insignificant. Fibrinogen and CRP in the postoperative period increased more significantly in group 2 than in group 1 (4,9±1,4 vs 4,4±1,1 g/l, р=0,02 and 8,6±2,2 vs 5,4±2,3 mg/l respectively, р<0,001). Conclusion. The study revealed an insignificant decrease in the number of AF episodes in the early post-CDS period in patients treated with omega-3 polyunsaturated fatty acids and atorvastatin compared with those given the latter medication alone. Also, fibrinogen and CRP levels as markers of inflammation increased while SOD antioxidative activity decreased.
Scars: characteristics of the development, diagnostics and correction of conservative methods.
Authors: Admakin Aleksandr Leonidovich
Published: November 2020

Scars are the vast number of people. At the same time their development proceeds differently in each case. It is influenced by a number of factors both external (terms of injury, environment, the vastness of the lesion) and internal (immune reactivity, genetic predisposition, etc.). The result of inadequate development of the scar can become overgrowth with the development of hypertrophic or keloid scarring, as well as the development of cicatricial atrophy. Diagnosis of scars is based on recording the data of objective and subjective analysis in the conventional scale. Among the methods of treatment of the isolated prompt and conservative, which have to be integrated. Most problematic is the choice of the local conservative treatment. The article, based on the analysis of literary sources, describes the most popular drugs (creams, ointments, gels, solutions) for application to the skin, evaluated its composition and properties, methods of communicating.
Prognosis of outcomes in planned surgery.
Authors: Kuznetsov Nikolay A.
Published: November 2020

The article is devoted to the problem of prognostication in planned surgery. In the course of stratification of operational risk, 16 perioperative prognostic criteria were identified, the formula of individual quantitative prognosis of planned operations in patients with benign and malignant diseases of the thoracic and abdominal cavity organs was developed, 5 types of operational prognosis were formulated. The described feature of the decision-making about the operation of the "problem" patients - shown to be prognostic indicators of high perioperative mortality should be regarded not as a pretext for refusing the operation, and as an incentive for carrying out an adequate preoperative therapy.
Comorbidity of chronic obstructive pulmonary disease and
ischemic stroke.
Authors: Geltser B. I. , Kurpatov I. G. , Kotelnikov Vladimir N. , Zayats Yu. V.
Published: November 2020

This review summarizes the literature on the problem of comorbidity of chronic obstructive pulmonary disease (COPD) and ischemic stroke (IS). The basic mechanisms of interrelation of these diseases. According to various sources the prevalence of IS in patients with COPD by 20% higher than in the general population. COPD and IS have common risk factors, the main of which is considered the age and smoking. Such manifestations of COPD such as chronic systemic inflammation (HSV), oxidative stress, accelerated atherogenesis, increased thrombotic risk events, arterial hypoxemia and hypercapnia may also influence the frequency of occurrence of IS. The importance given to the role in the development of COPD, certain subtypes of IS. Thus, HSV increases the intensity of the processes of atherogenesis and causes destabilization of atherosclerotic plaques, which increases the risk of developing atherothrombotic subtype of IS. COPD is a major factor of vascular comorbidity, promotes hemodynamic and cardioembolic subtype IS. It is therefore evident that a more frequent occurrence of ischemic central nervous system damage in patients with COPD compared to the general population is the result of the combined effect on cerebral blood flow and brain morphological structure of multiple pathogenic factors associated with systemic manifestations of the disease. Therapy options for comorbid COPD and IS flow needs to be improved. Thus, further study of comorbidity of COPD and AI mechanisms, understanding of the role and place of the respiratory and cerebrovascular syntropy, in the development of these diseases opens up prospects for the implementation of modern strategies of rational therapy.
Post-reperfusion syndrome in patients with ischemic heart disease after coronary stenting.
Authors: Komarova Irina S. , Zhelnov V. V. , Andreeva N. V. , Dvoretskiy L. I.
Published: November 2020

Post-reperfusion syndrome is a chronic multi-factorial syndrome, caused by restoration of coronary blood flow of de novo in patients after coronary stenting. Pathophysiological processes occurring in stenting segment (incomplete endothelization of vessel, excessive regeneration of neointima, formation of neoatherosclerosis) the risk of partial or total stent thrombosis due to the low level of compliance of the patient, as well as local changes in blood flow to the myocardium and modification of hemodynamics in stented arteries have a significant impact on the clinical course and prognosis of the disease. In contrast to the syndrome of reperfusion occurring after restoration of blood flow in the infarct-dependent coronary artery syndrome and postischemic reperfusion syndrome in patients with acute myocardial infarction after spontaneous or therapeutic thrombolysis, post-reperfusion syndrome is characterized by prolonged course (months and years). Clinical symptoms depend of the localization of pathological process (in stented arteries or in other non-stented arteries of the heart), as well as the presence of comorbidity and the factors of risk of the coronary heart disease.
Methods to monitor the therapy oral anticoagulants: the current problems.
Authors: Antovic J. , Kondratieva Tat'yana B.
Published: November 2020

Oral anticoagulants antivitamin-K (ОАС - AVК) are highly effective drugs that prevent the development of venous thrombosis, stroke in atrial fibrillation. Routine monitoring is not recommended for DOAC. If measurements are necessary LC-MS/MS is the gold standard. The classical coagulation assays, PT-INR and aPTT, have no or very limited utility. The absence of the ability of simple laboratory tests in emergent or urgent surgery or procedures still remains unresolved.
Predictive value of thromboembolic complications in infective endocarditis, the possibility of prevention.
Authors: Taranova M. V. , Androsova T. V. , Kozlovskaya L. V. , Strizhakov L. A. , Lebedeva M. V. , Milovanova L. Yu. , Mukhin N. A.
Published: November 2020

Thromboembolic syndrome is a formidable complication of infectious endocarditis (IE), which significantly worsens the prognosis. Data of literature and own results of studying of this problem are given. Among 64 patients of IE, who were under the supervision of the authors, thromboembolic syndrome was observed in 23 (36%; according to the literature - in 33-50%), including recurrent in 6. The main causative agent of the disease in this group was Staphylococcus aureus (42%), which is consistent with the data of the majority of authors, in the presence of large mobile vegetation with localization on the mitral valve, among patients without embolic events - Streptococcus viridans (47%) in the presence of smaller vegetation mainly on the aortic valve. The most dangerous thromboembolic complication was ischemic stroke in 8 (12.5%) patients, but embolic heart attack of the brain and myocardium is not always diagnosed in patients due to atypical course. The basis for the treatment and prevention of complications of IE, including thromboembolism, is early initiated adequate antibiotic therapy; at the same time, the principles of antithrombotic therapy in IE developed less. Given the high risk of intracranial hemorrhages, the decision to conduct thrombolytic therapy should be made individually by the so-called endocarditis team. The article discusses the indications for urgent surgical treatment to prevent thromboembolism.
For fulminant rapidly progressive glomerulonephritis in a 17-year-old female patient with ANCA-associated vasculitis.
Authors: Gordovskaya Nadezhda B. , Shilov E. M. , Korotchaeva Yu. V. , Stavrovskaya E. V. , Roshchupkin S. V.
Published: November 2020

A case of rapidly progressive glomerulonephritis in a 17-year-old patient associated with antibodies against the cytoplasm of neutrophils (ANCA) vasculitis - ANCA-associated vasculitis is associated with antibodies to proteinase-3 and morphological picture extracapillar glomerulonephritis with sclerotic lesion of up to 80% of the glomeruli. The peculiarity of the case is the presence of morphologically confirmed when alloimmune rapidly progressive glomerulonephritis type III a pronounced glow-focal granular nature of immunoglobulin classes G and M on the basement membrane of capillaries. The appointment of immunosuppressive therapy led to a decrease in systemic manifestations of vasculitis, but there was a rapid increase in terminal renal failure, which required substitution therapy with hemodialysis. The possible mechanisms of the rapid-training course of the disease in the observed patient, prospects for kidney transplantation are discussed.
Melatonin use in menopausal metabolic syndrome treatment.
Authors: Bruhina E. V. , Mamontova A. G. , Usoltseva Elena N.
Published: November 2020

Women in menopause have increased risk of such diseases, which is caused by nonreversible hormonal changes in the organism. At the current moment, it is well-known that in menopause conditions the decrease not only of the reproductive hormones level, but also of the epiphyseal melatonin hormone level, is observed. It was found out that parasecretion of the indoleamine is observed in the menopausal metabolic syndrome conditions. The scientific publications search was held in Russian and international data bases in the Russian and English languages. The article focuses on the experience of melatonin use in the complex therapy of metabolic syndrome, including women in post menopause. The results of researches, in which the melatonin influence on separate metabolic syndrome symptoms is studied, are examined in the article. Moreover, the article observes several scientific works, in which melatonin was used in metabolic syndrome treatment as a means of monotherapy. The analysis of the data allows us to conclude, that melatonin may be effectively used in the complex metabolic (including menopause) syndrome treatment.
The method of treatment forms hypotonic
dyskinesia of biliary tract in patients with chronic acalculous cholecystitis.
Authors: Khatsko V. V. , Mitroshin A. N. , Potapov V. V. , Zenin Oleg K. , Parkhomenko A. V.
Published: November 2020

Aim. To determine the rational volume of conservative therapy with form of hypotonic biliary dyskinesia and vegetative disorders in patients with chronic acalculous cholecystitis (CAC). Material and methods. The comparative retro- and prospective analysis of conservative treatment in 114 patients with CAC, who had been treated in the clinic the clinic of surgery. K.T. Ovnatanyana DonNMU of M. Gorky from 2008 to 2015. Among them were 67 females (59.1%) and 47 (40.9%) males at the age of 43,0 ± 6,7 years. The following methods were used to patients: biochemical blood analyses, ultrasound of hepatopancreatoduodenal area, fractional chromatic duodenal intubation with microscopic, biochemical and bacteriological studies of bile, the dynamic ultrasound examination of the gallbladder with test meal. All patients were divided into two homogeneous groups of 70 people. 1st group (main one) received treatment based on the type of dyskinesia of gallbladder and vegetative disorders (Patent of the Russian Federation № 2589900 from 02.06.2015), and 44 people. 2nd group (compare one) got only standard conservative therapy (table №5, holekinetiki, choleretic and others.). Results. The treatment program of CAC consisted of dietotherapy, drug therapy during the exacerbation; pain relief; using of choleretic drugs; antibiotic therapy; normalization of the functions of the autonomic nervous system; immunomodulatory therapy, and improving of the general reactivity of the organism. At the hypotonia gallbladder good effect was obtained of using of Gerbastress with Polyphytohol and Vitam (Patent of the Russian Federation № 2589900 from 02.06.2015). In the 1st group various complications were noted in 2.1%, in the 2nd group - in 5.4%. In a remote period (after 1-5 years) the best indicators of the quality of life were in the 1st group. Conclusions. Using developed an improved method of treatment causes a more expressed in comparison with the control group, a reduction of pain, dyspeptic and asthenic-vegetative syndromes, improve the functional state of the biliary tract and biochemical indices of bile, improving the quality of life on all scales by 1.3-1.7 times .
Option determine the need in the hospital at home on the basis of outpatient organization.
Authors: Minaev Nikolay V.
Published: November 2020

The article describes the original version of the definition of needs in the organization of hospital at home on the basis of outpatient department. In the introduction the urgency of developing methods for determining the need for the organization of hospital at home, listed goal and research materials. The necessity of performance indicators of outpatient department, used in the methodology. The substantiation of evaluation criteria of outpatient department for making decisions about the opening of the hospital at home, a procedure of calculating needs for specific forms of work of hospital at home, which is automated by using originally developed computer program written in the algorithmic language Visual Bacic 6.0; outlined the plan developed by the program. The following is the description of the program and brief instructions on use. Shows the potential social and economic effect from the use of the program. The conclusion about expediency of application of the programme in the national healthcare.
Inflammation in chronic kidney disease: sources, consequences and anti-inflammatory therapy.
Authors: Aitbaev K. A. , Murkamilov Ilkhom T. , Fomin V. V. , Murkamilova J. A. , Rayimzhanov Z. R. , Yusupov F. A. , Aidarov Z. A.
Published: November 2020

The role of various factors contributing to the development of systemic persistent low-grade inflammation in chronic kidney disease (CKD) is considered. It is reported that inflammation in patients with CKD is directly correlated with the glomerular filtration rate (GFR) and culminates in the terminal stage of renal failure, where extracorporeal factors such as dialysate contaminants, dialysate microbiological quality and the biocompatibility of factors in the dialysis chain play an additional role. The effectiveness of therapeutic interventions aimed at correcting inflammation in patients with CKD is discussed. Further investigations are needed to evaluate the effects of these interventions on hard outcomes, as well as to better understand the role of inflammation in selected CKD populations, particularly in children.
The factors inflyencing the diffusion
capacity of the lung in patients with myocardial infarction.
Authors: Karetnikova V. N. , Katsyuba M. V. , Polikutina O. M. , Slepynina Y. S. , Barbarash O. L.
Published: November 2020

The purpose of the study was to assess the factors associated with impaired lung diffusion capacity among the patients with STEMI. Material and methods. 107 patients with STEMI were included. Echocardiography, spirometry, body plethysmography, diffusion capacity of the lungs, laboratory indices of inflammatory status and myocardial dysfunction were performed on the 10-12 days of the hospital admission. 100 (93,4%) patients underwent percutaneous coronary intervention with stenting. Results. In the 1st group were included 59 (55,1%) patients with a normal diffusing lung capacity, in the 2nd group - 48 (44,9%) patients with reduced diffusing lung capacity (<80%). Patients of the 2nd group showed lower values of FEF75%, the increase of the end systolic volume LV, right and left atrial volume, and the increase concentrations of CRP in blood plasma. The discriminant analysis identified the factors affecting the decrease in DLCO. Conclusion. The factors associated with impaired lung diffusion capacity among the patients with STEMI are the following: age, maximum expiratory flow at the level of distal bronchi, the volume of the left atrial and the concentration of C-reactive protein, assessed on the 10th day of the disease.
Intraepithelial colorectal lesions in women with cervical infection with human
papillomavirus.
Authors: Alyautdina O. S. , Sinicina O. V.
Published: November 2020

Human papillomavirus (HPV)-induced cervical cancer and colorectal cancer are closely related. Women with cervical HPV infection have more than 3 times the high risk of anal infection. Some studies indicate a persistent relationship between colorectal cancer caused by HPV infection and a similar genotype of cervical cancer. In our research, using the method of liquid cytology, a comparison of colorectal HPV lesion in patients with dysplasia of the cervix in history and a control group without pathology of the cervix was carried out. The cytological study was performed using the method of liquid cytology BDShurePath using the automated scanning system BDFocalPoint. Detection of HPV genotypes of high oncogenic risk (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68) was carried out by hybrid capture (HPVdigene-test hybrid capture ll).The results of our studies showed that 24% of patients at high risk in the cytological examination of scrapings from the rectum had an intraepithelial lesion of the rectal epithelium, most likely associated with HPV infection. In the control group, these changes were not observed. The results show that HPV-associated pathology of the cervix is a risk factor for intraepithelial damage to the rectum. Such patients are in a group at high risk of developing colorectal cancer and should undergo a regular appropriate examination.
Chronic pain syndrome after total hip arthroplasty.
Authors: Jusupov K. S. , Pavlenko N. N. , Sertakova A. V. , Anisimova E. A.
Published: November 2020

Introduction. One of the total hip arthroplasty complications is a chronic pain syndrome at different time period. Pain occurs inapproximately 27% ofpatients asdiscomfort and 6% - as persistent pain. Material and methods. We analyzed the results of total hip arthroplasty in140 patients with chronic pain syndrome (85 women and 55 men, mean age 53.4±0.5 years), operated in 2013-2016. As a basic diagnostic causes’s criteria we used hip joint X-ray, methods of ultrasound, magnetic resonance imaging and electroneuromyography. All established pathological processes that trigger the pain were divided into X-ray positiveandX-ray negative. Results. The influence of the following trigger factors ofpain was observed: body weight, age and musculoskeletal system state. Thus, the greatest number of complications and development of pain was seen in patients with excessive body weight or obesity. Spinal column pathology in lumbosacral section led to the reduction in the quality of patient life after total hip arthroplasty. Age up to 50 years and active life style promoted various reactions of bone remodeling in the area of implant pressure. Conclusion. The frequency of complications after surgery leading to chronic pain in our study was consistent with global indexes, and in some cases, was lower.
Bronchial asthma and the vitamin D deficiency.
Authors: Fomina D. S. , Markova T. N. , Sadovskaya V. V.
Published: November 2020

The variety of tissue cells express receptors of vitamin D. The possible causative connection between lack of vitamin D and a number of inflammatory diseases such as bronchial asthma has stimulated interest in the potentially positive effects of vitamin D in the theraputic schemes. Conflicting data was demonstrated by numerous studies concerning the relationship of vitamin D and development of asthma . Most of them stress attention on the lack of studies with targeting population excluding subclasters and phenotypes of bronchial asthma, especially groups associated with low levels of vitamin D obesity, COPD and asthma, atopic patients. The question of prescribing of vitamin D in asthma, in the case of laboratory-proven deficiency or lack of vitamin D can be an option in therapy.
Cardiac involvement in some rheumatic diseases.
Authors: Feiskhanova L. I. , Khaliullina L. R.
Published: November 2020

The review covers the modern scientific literature about cardiovascular disease in patients with rheumatic diseases. Rheumatic diseases are associated with chronic inflammation, most often joints, skin, eyes, lungs, kidneys and circulatory system. Cardiovascular manifestations of autoimmune diseases can be mild and clinically silent; they can also increase morbidity and mortality. Defeat of cardiovascular system at patients with rheumatoid arthritis: myocarditis, a pericarditis, myocardial fibrosis, ventricular arrhythmias, a syndrome of the extended interval of QT, atrial fibrillation, valvulopathy, development of chronic heart failure, formation of heart disease. Cardiac involvement in systemic lupus erythematosus follows different pathophysiologic mechanisms and covers a wide spectrum of clinical phenotypes including pericarditis, myocarditis, valvular abnormalities, aseptic endocarditis, heartfailure, ischaemic heart disease and pulmonary hypertension. Valvular disease in systemic lupus erythematosus includes valvulitis, aortic and mitral regurgitation, aortic stenosis. For diagnosis of cardiovascular diseases are used clinical laboratory methods, the electrocardiogram, echocardiography, single-photon emission computed tomography, positron emission tomography/ computed tomography, computed coronary angiography, computed tomography, magnetic resonance imaging. The following echocardiographic abnormalities have been reported in ankylosing spondylitis: ascending aortitis, aortic and mitral regurgitation, mitral valve prolapse and diastolic dysfunction. The following echocardiographic abnormalities can be seen in psoriatic arthritis: fibrinous pericarditis, myocarditis and valvular disease.
Portrait of the patient with myocardial infarction over a 30-year period.
Authors: Garganeeva A. A. , Tukish O. V. , Kuzheleva E. A. , Okrugin S. A. , Kuzmichkina M. A.
Published: November 2020

Aim. To study how to change the portrait of the patient with acute myocardial infarction (AMI) for a 30-year period in the global aging of the population, and conduct a comparative assessment of the main epidemiological indicators of AMI over the period of time. Material and methods. The study included patients with AMI registered in the database «Register of acute myocardial infarction» in 1986 (593 cases) and 2015 (729 cases), respectively. Statistical processing of the results was performed using the statistical program Statistica V10.0. Results. Over a 30-year period, the proportion of elderly patients increased by 13.4% (p<0.001). Among men younger than 60 years decreased morbidity, mortality, and hospital mortality from AMI. In persons 60 years and older reduced the incidence of first AMI, however, the incidence of re-AMI and morbidity and mortality has not decreased. Often the AMI was to develop on the background of comorbidities (p<0.001). A marked increase in the number of atypical forms of the disease from 11.6% in 1986 to 33.2% in 2015 (p<0.001), mostly among patients of older age groups. Elderly patients are often hospitalized in non-core hospitals (7.7% in 1986 compared to 13.6% - in 2015; p<0.001). There was an increased incidence of acute left ventricular failure, cardiogenic shock, arrhythmias (p<0.001). Conclusions. Thus, the significant increase ofpatients' age at the time of development of AMI in 2015, compared with 1986, is a reflection of the process of demographic aging of the population, and inevitably leads to the accumulation of comorbid pathology, weighting demographic status of patients, the clinical picture of the disease and causes to significant difficulty in providing effective specialized medical care to patients.
Results of percutaneous coronary interventions in patients with dysfunctional myocardium.
Authors: Rustamova Ya. , Imanov G. , Azizov V.
Published: November 2020

Aim: to evaluate immediate and long-term results of endovascular treatment of patients with dysfunctional viable myocardium. Material and methods. 220 patients were included in the study and were divided into 2 groups. The main group (n=138) included patients with proven ischemia and the presence of viable myocardium in the post-MI zone, on account of which they performed endovascular intervention on the arteries that supply the viable myocardium. The control group (n=82) was formed retrospectively and included patients who were on optimal medical therapy, with invasive diagnostics and endovascular treatment not performed by such patients. The viability of the myocardium was determined by the methods ofMRI of the heart with delayed contrast and the method of stress echocardiography with dobutamine. Inclusion criteria: angina pectoris II-IV functional class (CCS); the presence of proven myocardial ischemia according to stress tests; occlusion or subtotal stenosis of one or more coronary arteries according to digital angiography (SYNTAX score <32); presence of segments with disturbed local contractility of left ventricular myocardium; presence of a viable myocardium in the zone of the occluded / stenotic artery; circulatory failure of I-III functional class (NYHA); left ventricular ejection fraction (LVEF) less than 50%. Results. The magnetic resonance imaging (RMI) with delayed contrasting at the preoperative stage allows to reliably estimate the existing violations of local contractility in the zone of the hibernated myocardium, in comparison with the method of stress echocardiography with dobutamine. After 12 and 18 months of follow-up, there was a significant increase in the incidence of non-fatal MI in the control group. In all patients in the long-term period after PCI completion, a significant increase in the left ventricular ejection fraction and an improvement in the local contractility of the myocardium are noted. Among patients who underwent MRI of the heart, it was possible to detect a significant decrease in the mass fraction of ischemic myocardium in the post-MI zone. There was a strong positive correlation (r = 0.54, p<0.05) between the duration of myocardial hibernation and the timing of restoration of its function after PCI. Conclusion. PCI performance in patients with dysfunctional viable myocardium is highly effective, compared with patients receiving only medication. The method of MRI of the heart with delayed contrast allows judging more objectively the dynamics Оригинальные исследования of the restoration of the function of the hibernated viable myocardium and remodeling of the heart after the revascularization, in comparison with stress echocardiography with dobutamine.
Violencia Digital contra la mujer en México: Honor, imagen y daño moral. El espectro del derecho penal simbólico en la ‘Ley Olimpia’
Authors: Ruiz Canizales Raúl
Published: November 2020

El presente artículo tiene como objetivo realizar un análisis crítico respecto de la configuración, en la legislación mexicana, de los nuevos escenarios de violencia digital contra la mujer, la protección del derecho al honor y el daño moral. Se hace una revisión crítica de la producción legislativa destinada a sancionar la violencia digital por medio de las TIC, así como para proteger el honor y las limitaciones de la reparación del daño moral. A partir de la propia caracterización del derecho penal simbólico, se arriba a la tesis de que la parte punitiva de esa producción legislativa contiene fuertes dosis de elementos que caracterizan al populismo penal y, por tanto, esto implica que, lejos de cumplirse el objetivo planteado por el legislador, se desprenden problemas de integración del enunciado jurídico. El caso emblemático lo constituye la denominada Ley Olimpia.
Enseñanzas del covid-19
Authors: Díaz-Gamboa Luis Bernardo
Published: November 2020

El confinamiento del mundo ha traído importantes enseñanzas. Si bien pandemias del pasado como la viruela, la peste negra o la gripe española generaron un mayor número de muertos, un elemento en el siglo XXI hace que juegue un papel esencial en la contención viral: la información. De acuerdo con esta afirmación, el permanente monitoreo de la Universidad John Hopkins, las noticias inmediatas sobre el número de muertos, contagiados y recuperados, casi en tiempo real, demuestra que hoy en día el ataque puede ser controlado. Al respecto se puede ver que: China abrió Wuhan, donde nació el coronavirus. Tuvo tres meses de medidas draconianas. Y hoy cero muertos. Claro que los sub-registros son preocupantes, así como los casos asintomáticos.
Entre el nazismo y la dignidad : retos de los derechos humanos en el siglo XXI
Authors: Restrepo Domínguez Manuel Humberto
Published: November 2020

Este libro, se mueve entre explicaciones a la vigencia del nazismo y el reto de la dignidad, para iniciar el diálogo a propósito de una de las últimas reflexiones del autor en torno a los derechos humanos. Lo hago agradecido porque, una vez más, Manuel Restrepo me concede la palabra y porque defender la dignidad humana, me anima a correr el riesgo de errar, hablando de primero, un honor que no merezco. Hago parte de un proyecto que desde hace ya incontables años comenzó a liderar el Profesor Restrepo en la Universidad Pedagógica y Tecnológica de Colombia. En su transcurso derivó en lo que hemos decidido llamar Perspectiva Crítica de los Derechos Humanos. Las reflexiones que hoy nos presenta el autor son un paso adelante en esta línea. Sólo en el marco de este enfoque crítico, dentro del cual seguimos colocando los mojones necesarios para estructurar lo que sería un pensamiento crítico en materia de derechos humanos, es que se pueden entender y asumir los aportes que aquí se nos ofrecen. O, de otro modo: si las siguientes páginas se leen dentro de las corrientes tradicionales del iusnaturalismo o del iuspositivismo, se sospecharía que en este texto no hay una reflexión sobre los derechos humanos sino, en el mejor de los casos, sobre asuntos colaterales a los mismos. No obstante, de manera contraria podemos afirmar que aquí se formulan tópicos centrales para repensar los derechos humanos y, con ello, relegitimar, de otra forma, su vigencia.
Perolehan Hak Milik Yang Berasal Dari Perjanjian Pengikatan Jual Beli (Ppjb) Terhadap Bangunan Yang Berdiri Di Atas Tanah Negara Bekas Hak Eigendom
Authors: Habiba Diyah Retno
Published: November 2020

Sebelum berlakunya Undang-Undang Pokok Agraria, sistem pertanahan di Indonesia masih menganut pada hukum adat dan hukum barat. Salah satunya hak eigendom yang setelah berlakunya Undang-Undang Pokok Agraria, hak eigendom ini sudah tidak berlaku lagi dan harus dikonversi sesuai dengan Ketentuan Konversi Undang-Undang Pokok Agraria. Metode penelitian yang digunakan yaitu metode normatif dengan melalui pendekatan undang-undang dan pendekatan konseptual. Dalam penelitian ini, diketahui bahwa jual beli tanah menimbulkan perbuatan hukum pemindahan hak yang menganut asas tunai, riil dan terang. Selain itu, terdapat syarat sahnya jual beli yang harus dipenuhi guna menghasilkan akta jual beli sebagai alat bukti tertulis yang bersifat akta otentik. Mengenai prosedur perolehan hak milik atas tanah negara sudah tercantum dalam Peraturan Menteri Negara Agraria/Kepala Badan Pertanahan Nasional Nomor 9 Tahun 1999 tentang Tata Cara Pemberian dan Pembatalan Hak Atas Tanah Negara dan Hak Pengelolaan yang diajukan secara tertulis kepada Menteri melalui Badan Pertanahan Nasional Kabupaten/Kota.
ASYMMETRICAL BASIS OF THE ANTITHESIS WITH THE OPPOSITION SELF / OTHER IN MODERN MEDIATEXTS
Authors:   Kuban State University, Ponomarenko I.N. , Kryzhanovskaya V.A. ,   Kuban State University, Segal N.A. ,   The Vernadsky Crimean Federal University
Published: November 2020

The article analyzes the asymmetrical basis of the antithesis with the opposition self / other in modern mediatexts. The aim is to state and interpret the peculiar linguistic realization of the asymmetrical basis of the antithesis with the opposition self / other in modern mediatexts. The study systematizes theoretical statements arguing asymmetrical relations as basic characteristics of language and text. Besides, it proves dominating role of asymmetry in modelling Russian media space. The article highlights that media discourse asymmetry, which became the object of scientific research only in the last decade, is caused by the manipulative character of media texts. As a result of factual material analysis, there was made a conclusion that early XXI century mediatexts are a priori asymmetrical. They contain both communicative and linguistic asymmetry resting mainly on contrast between linguistic and contextual antonyms which demonstrate diametrically opposite political views and divide political space into self and other. Antithesis self / other is not only a key opposition of political discourse; it also models socio-political relations. The article contains analysis of the opposition self / other as well as its explicators we / they, friend / enemy used in mediatexts. The study proves axiological fixedness of all explicators of the antithesis opposition conditioned by both linguistic and extra linguistic reasons. The authors draw the conclusion that actual mediatext based on the antithesis with the opposition self / other is the crucial way for politicians and journalists to manipulate the subjects of political communication by forming constructive or destructive images of states, political leaders, parties or organizations. A significant result of the study is that interaction of the addresser’s and addressee’s cognitive systems is based on historical and socio-political experience, the system of values, the idea of state’s as well as individual politician’s perspective. It is combination of factors that makes the foundation for coding and decoding information, and routes realities of political world basing on the opposition self / other.
The Role of Divalent Transition Metal Ions in the Binding of Fur Dimer to DNA: Binding of Mn2+ and Co2+ to EC Fur dimer-DNA Complex
Authors: Hamed Mazen , Jabour Salih
Published: November 2020

Ferric uptake regulation protein is a repressor protein which binds an AT rich region of DNA (the iron box). Fur binds as a dimer in a helix turn helix mode and it is activated by iron(II) and other transition metal ions at elevated concentrations. Each transition metal ion induces certain conformational changes to aid the Fur binding, both the N-terminal and C-terminal domains take part in binding to DNA in addition to His 88 and His 86. The process is discussed in view of experimental reports. Fe(II), Mn(II) and Co(II) activate Fur to bind DNA but Zinc plays a structural role and does not activate Fur to bind DNA.