bluuebunny/crossref_metadata_2025 huggingface dataset:
Virgin Olive Oil Phenolic Compounds: Insights on Their Occurrence, Health-Promoting Properties and Bioavailability
Authors: Amine Ajal El , Chaji Salah , Moussafir Sanae , Nejjari Rachid , Soulaymani Abdelmajid , Bajoub Aadil
Published: July 2021

Virgin olive oil is a highly appreciated edible oil, considered as a relevant component of the Mediterranean diet. The spread of this foodstuff all over the world is making, to a certain extent, that new markets and consumers are getting used to this “Mediterranean’s golden treasure”. Currently, there is great momentum in research relating virgin olive oil intake to healthiness, which has been mainly associated with its phenolics content. Phenolics are considered health-promoting compounds due to their multifaceted biochemical actions that can potentially reduce the risk of various health problems. Yet, since the health-promoting effects of various phenolic compounds have been widely attributed to their metabolic products rather than the naturally occurring forms, the assessment of virgin olive oil phenolics bioavailability is still gaining immense attention and considered a great hot topic among researchers. In the first section of this contribution, the main groups of phenolic compounds identified in virgin olive oil are described, their qualitative and quantitative variability is discussed while analytical approaches applied for their determination are highlighted. The second section reports the beneficial health properties of virgin olive oil consumption related to its phenolics content paying special attention to their bioavailability.
Management of Post-Circumcision Glans/Penile Necrosis
Authors: Arikan Yusuf , Ayten Ali
Published: July 2021

Circumcision is the surgical removal of the skin covering the glans and is one of the oldest and most common surgical procedures in the world. Although there is evidence that the first circumcision was performed in Egypt in 4000 BC, according to some anthropologists, it dates back to the 10th millennium BC. The purpose of medical circumcision is to obtain enough foreskin to expose the glans penis and to prevent medical problems caused by the foreskin. Although it is known that the complications arising from these procedures are not well documented, the complication rates in the literature vary between 1 and 15%, when evaluated according to age, the rate of post-circumcision complications in newborns is reported to be approximately 0.2-0.6% and this rate is 10 times higher between the ages of 1-9. Various complications such as bleeding, infection, incomplete and insufficient circumcision, hematoma, penile adhesion, urinary retention, glanular injury, necrosis and urethral narrowing have been reported. In this book section, one of the complications, penile necrosis, will be explained in the light of the literature.
Analytical Accuracy of RET Fusion Detection by Break-Apart Fluorescence In Situ Hybridization
Authors: Baker Jessica A. , Sireci Anthony N. , Marella Narasimha , Cannon Holly Kay , Marquart Tyler J. , Holzer Timothy R. , Reising Leslie O'Neill , Cook Joel D. , Wijayawardana Sameera R. , Bodo Juraj , Hsi Eric D. , Schade Andrew E. , Oakley Gerard J.
Published: July 2021

Context.—

RET gene fusions are oncogenic drivers in nonsmall cell lung cancer and nonmedullary thyroid cancer. Selpercatinib (RETEVMO), a targeted inhibitor of RET, was approved by the US Food and Drug Administration for the treatment of RET fusion–positive nonsmall cell lung cancer and nonmedullary thyroid cancer emphasizing the need for rapid and accurate diagnosis of RET fusions. Fluorescence in situ hybridization (FISH) has been used to detect gene rearrangements, but its performance detecting RET rearrangements is understudied.

Objective.—

To validate and describe the performance of Abbott Molecular RET break-apart FISH probes for detecting RET rearrangements.

Design.—

A training set with RET fusion–positive (13) and RET fusion–negative nonsmall cell lung cancer and nonmedullary thyroid cancer samples (12) was used to establish criteria for FISH scoring. The scoring criteria was then applied to a larger validation set of samples (96).

Results.—

A cutoff of 19% or more positive nuclei by FISH was established in the training set and determined by the mean ±3 SD. The validation set was tested using Abbott Molecular RET break-apart FISH compared with sequencing. With this cutoff, a sensitivity of 86% (12 of 14) and specificity of 99% (81 of 82) was achieved. Bootstrapping showed sensitivity could be optimized by using a greater than 13% cutoff with indeterminate samples of 13% to 18% abnormal nuclei requiring confirmation by an orthogonal method. Using this 3-tier scoring system sensitivity increased to 100% (14 of 14) and specificity was 96% (79 of 82).

Conclusions.—

Abbott Molecular break-apart FISH probes can be used to detect RET fusions. Laboratories can optimize cutoffs and/or testing algorithms to maximize sensitivity and specificity to ensure appropriate patients receive effective, timely therapy.
Narrativas na (e para a) formação de professores: algumas mobilizações no âmbito do Pibid-UFSCar
Authors: Zaqueu-Xavier Ana Claudia Molina
Published: July 2021

Apresentar e discutir alguns modos de mobilização de narrativas na (e para a) formação de professores no Programa Institucional de Bolsas de Iniciação à Docência (Pibid) da Universidade Federal de São Carlos, UFSCar, é o objetivo deste artigo. Para isso, nos respaldamos em narrativas - produzidas no âmbito de uma pesquisa de doutorado - de oito coordenadores de área de subprojetos e de dois ex-coordenadores institucionais do Pibid-UFSCar, bem como em documentos oficiais que versam sobre o programa desta instituição. Trata-se, portanto, de um trabalho qualitativo cujo movimento analítico foi inspirado no modelo de análise narrativa. Isto porque, optou-se por assumir as narrativas como foco do estudo, sobretudo, por defendermos que nossos interesses de pesquisa estavam pautados na subjetividade dos sujeitos e, nessa direção, as narrativas podem ser tomadas como espaços nos quais eles tecem sentidos, criam significados e se constituem nos diferentes espaços e tempos. A partir disso, apresentaremos uma versão possível para o Pibid-UFSCar bem como alguns modos de mobilização de narrativas na (e para a) formação docente, enfatizando o trabalho com portfólios por eles desenvolvidos. De modo geral, chamaremos atenção do leitor para algumas das potencialidades do trabalho narrativo percebidos nesse cenário como, por exemplo, a criação de um espaço menos verticalizado para discussões e problematizações de temas e ideias, a possibilidade de acompanhamento do processo de tornar-se professor, a contribuição para o desenvolvimento da Língua Portuguesa, da escrita, da oralidade, dentre outros aspectos.
Exhibitionary complex: Architecture as an exhibit
Authors: Pešić Mladen
Published: July 2021

Within this research, the exhibitions are considered primarily as institutions, and as a place of interaction among different identities through choice of exhibits, their presentation, spatial layout and the selection and use of the accompanying texts. The context of the research thus put into place will attempt to answer the question of how it is possible to construct a history of the exhibitions-which are forgotten, often without sufficient documentation or records about them. In addition, it will be reconsidered in which manner the exhibitions helped to create and promote the idea of architecture during the 20th century, overlapping with the shifting of discourses, broader philosophical debates and technological innovations.
Academic course: About and around curating: The technology of an exhibition process: The realization of project "Real World"
Authors: Bereta Andrej , Tunić Srđan
Published: July 2021

As an extended part of independent curatorial project About and Around Curating/Kustosiranje, art historians and freelance curators Bereta and Tunić developed a special academic course for the University of Belgrade, Faculties of Architecture and Fine Arts during the autumn semester 2012/13. Rooted in experience based methodology and inspired by contemporary curatorial studies in Europe, the official course curriculum gathered undergraduate students of Architecture, Fine Arts (Department of Sculpture) and Art Historians. The aim of the course was to encourage team working of students of different backgrounds in order to create newly produced artworks, as part of a group exhibition. The course itself was intended to be a reaction and constructive critique towards the lack of cooperation between art faculties, low rate of practical activities during studies and seeing curatorial studies solely as a world of ideas.
CONTRIBUÇÕES DA EXTENSÃO NA FORMAÇÃO ACADÊMICA E SOCIAL
Authors: Barbosa Mariana Laporta
Published: July 2021

Este artigo tem como objetivo analisar a trajetória do Núcleo Extensionista Rondon (NER), experiência de Extensão Universitária desenvolvida há dez anos pela Universidade do Estado de Santa Catarina (UDESC). Atuando de forma descentralizada, o NER insere discentes e docentes na realidade social catarinense, através de ações realizadas periodicamente. Em suas inserções, são desenvolvidas atividades baseadas nos oito eixos da Extensão Universitária, abrangendo assim, pautas educacionais, culturais, sociais, além de outras necessidades locais. Este artigo caracteriza-se pelo método de estudo de caso, utilizando as técnicas de análise documental, entrevista e questionário para a coleta dos dados. A partir das percepções dos discentes e docentes captadas neste trabalho, é possível ter uma ideia do tamanho e relevância do Núcleo. Percebe-se nas respostas, que ao agregar ao processo de formação acadêmica, a ação vai além da qualificação científica.
EMPREENDEDORISMO SOCIAL NO NÚCLEO EXTENSIONISTA RONDON/UDESC
Authors: Bittencourt Donizete de Souza , Márcia Marques Santos Vera
Published: July 2021

Este artigo analisou a correlação entre as atividades realizadas no NER/UDESC com o empreendedorismo social.  No decorrer da pesquisa, percebemos que o trabalho interdisciplinar realizado pelo referido núcleo favorece a visão integradora social, aliando o conhecimento acadêmico do ensino com as atividades de extensão universitária. Essas, por sua vez, reverberam nas comunidades, cumprindo com uma importante função para a formação acadêmica e retorno deste conhecimento para a sociedade. Cabe ressaltar que as atividades realizadas, foram subsidiadas nas oito áreas da Extensão Universitária, e são realizadas com pessoas de todas as faixas etária, nas diversas regiões do Brasil. Essas atividades exemplificam a justificam o empreendedorismo social, que vem emergindo desde a década de 1990, caracterizando-se pela responsabilidade social, considerando-se que os empreendedores sociais não visam lucro e sim o bem-estar coletivo, o empreendedorismo social.
PROJETO RONDON
Authors: Lima Eduardo do Valle
Published: July 2021

O presente relato de experiência trata da participação de 02 (dois) docentes e 08 (oito) discentes da Universidade Federal Rural da Amazônia – UFRA do Pará, da 16º Operação realizada pelo Núcleo Extensionista Rondon – NER / UDESC, no oeste de Santa Catarina. O desafio institucional foi aceito com o objetivo de entender a aplicação do Projeto Rondon desenvolvido a 10 (anos) pelo NER / UDESC, como poderosa ferramenta de Extensão Universitária. O Projeto Rondon desenvolvido pelo NER / UDESC não leva somente serviços a sociedade para o seu desenvolvimento sustentável, mas permite aos dissentes de graduação a oportunidade de vivenciarem suas teorias acadêmicas na prática da sociedade. Tudo de forma não assistencialista, pois a troca de saberes se constitui em princípio básico. Há o fortalecimento da formação cidadã aos discentes e a essência de uma educação popular para todos, que extrapola o conceito de carência. Futuramente esta metodologia de Projeto Rondon também poderá ser aplicada pela UFRA no Pará e Amazônia

PALAVRAS-CHAVE: Educação Superior. Educação Popular. Operação Rondon. Oficinas Rondon. Núcleo Extensionista Rondon.
CONTRIBUIÇÕES DA PARTICIPAÇÃO NO NER – UDESC
Authors: Cunha Aline Fagundes
Published: July 2021

O âmbito da Extensão Universitária, articulada ao ensino e pesquisa de forma indissociável,
compreende uma importante estratégia para a formação pessoal e profissional dos acadêmicos. A elaboração deste trabalho por meio de relato de experiência, busca apresentar a trajetória pessoal e profissional da autora e sua relação com a Extensão Universitária principalmente com o Projeto Rondon. Projeto este que tem papel fundamental em sua formação acadêmica, visto que de maneira transformadora permitiu a compreensão das diferentes possibilidades de inserção do profissional de enfermagem nas comunidades, bem como a superação de diversos obstáculos profissionais ao longo de sua carreira e sua vida.
IMPACTO E TRANSFORMAÇÃO PESSOAL E SOCIAL
Authors: Frutuoso Tomé de Pádua
Published: July 2021

Este relato de experiência tem como tema principal a atuação extensionista junto ao Núcleo Extensionista Rondon NER da UDESC, seus desdobramentos e consequências. Tem como objetivo apresentar o entendimento do autor sobre o conceito de extensão praticado no Brasil e sua participação nas atividades extensionistas relacionadas ao NER UDESC, além de apresentar a relevância do impacto e transformação discente proporcionados pela extensão.
RELATO DE EXPERIÊNCIA DE UMA OPERAÇÃO DO NÚCLEO EXTENSIONISTA RONDON (NER-UDESC)
Authors: Passos Willian Clemente dos , Cruz Lívia da , Alexandre Katia
Published: July 2021

Compreende-se a indissociabilidade entre o ensino, a pesquisa e a extensão no que cabe à sustentação e formação da instituição universitária, como a etapa de desenvolvimento técnico e profissional da comunidade que representa, atua e se forma nesse espaço. E tendo a ciência de que as práticas interventivas e formativas nesses espaços possuem variação, é pertinente investir na aproximação entre os saberes científicos, populares e, principalmente, humanizados, o que é reforçado pelas ações de extensão. Desta forma, o presente trabalho tem como objetivo apresentar os resultados obtidos a partir da aplicação de uma oficina desenvolvida e aplicada com a temática sexualidade durante uma Operação do Núcleo Extensionista Rondon da Universidade do Estado de Santa Catarina (NER-UDESC) intitulada de Operação Elpídio Barbosa, que ocorreu no município de Joinville no ano de 2015. A sexualidade humana, tema desta oficina, é representada por uma diversidade de aspectos, perspectivas e expressões, no entanto, para o desenvolvimento da oficina em questão, optou-se por focar em três pontos essenciais: identidade de gênero, orientação sexual e sexo biológico. A oficina foi aplicada com três grupos de estudantes, de 13 a 16 anos e teve duração de 90 minutos cada, somando ao todo 50 participantes. A oficina baseou-se na apresentação de um boneco e uma boneca, desenhados em uma folha e representado(a) por três pontos: 1 - a cabeça (espaço das ideias); 2 - o tronco (espaço das emoções); 3 - as genitálias/cromossomos (gênero e interesse sexual); e na motivação aos(as) participantes em apresentarem e compartilharem suas impressões sobre cada um dos pontos. Os resultados apresentados e discutidos neste trabalho foram coletados a partir destes discursos, falas e apontamentos realizados pelos(as) participantes, dos quais podemos destacar: o debate sobre a disposição de um banheiro unissex em empatia com os(as) colegas homossexuais e transgêneros e a minimização da caracterização pelo sexo biológico; as diferenças nos tratamentos no ambiente escolar e familiar demarcadas pelo gênero do(a) estudante; e as reflexões norteadas pelo modo que as relações sociais são constituidas, na percepção fragilizada sobre os discursos verbalizados pelos(as) jovens, e da urgência da legitimação política dos mesmos. Por fim, concluímos com o presente trabalho que a extensão universitária permite que os diálogos entre a teoria e a prática ultrapassem o ambiente acadêmico, e se envolva com a comunidade geral, e que as Operações e Ações do NER-UDESC tem promovido encontros, debates e atividades pautadas na lógica do compartilhamento de saberes e de aproximação entre o ambiente acadêmico e a comunidade. Exposto isso, esperamos que este trabalho contribua para uma maior valorização da extensão universitária, bem como no aumento do interesse de estudantes, professores(as) e técnicos(as) em participar destas ações.
HIERARCHICAL STRUCTURE AND CAUSAL RELATIONSHIPS OF BARRIERS TO SOCIAL DIMENSION IN SSCM VIA NOVEL DEMATEL-ISM INTEGRATED APPROACH
Authors: Chen Jih-Kuang
Published: July 2021

Abstract:
Sustainable Supply Chain Management (SSCM) encompasses a Triple Bottom Line (TBL) consisting of : a) economic benefits, b)environmental protection, and c) social responsibility. Previous studies have focused solely on profitability or environmental dimensions while generally neglecting the social dimension. Decision Making Trial and Evaluation Laboratory (DEMATEL) and Interpretive Structural Modeling (ISM) techniques can identify causal relationships and hierarchical structure among factors, two techniques are commonly used separately or also may be integrated per their common characteristics with a relatively small computational burden. However, conventional DEMATEL-ISM integrated method has notable drawbacks and may not provide accurate analysis results. The purpose of the present study is to suggest the novel DEMATEL-ISM integrated approach to improve the shortage of conventional DEMATEL-ISM integrated method as well as investigate the hierarchical structure and causal relationship of social dimension barriers for SSCM implementation. A series of 13 barriers to SSCM social dimension implementation were identified and placed into a five-layer hierarchical structure. The most important barriers were found in addition to lack of government support and low market demand for sustainable products, and causal relationships among barriers were also identified for the Guangdong-Hong Kong-Macao Greater Bay Area of China.

Key words: SSCM social dimension; DEMATEL-ISM integrated; Hierarchical structure and causal relationships
Why We Should Tackle Suppressive Gender Stereotypes in the Manosphere
Authors: Skewes Lea
Published: July 2021

Laura Bates:Men Who Hate Women – From Incels to Pickup Artists, The Truth About Extreme Misogyny and How It Affects Us AllSimon & Schuster, London, pages 360, Price: 199,95 DDK at SAXO
The Effect of Patient-controlled Intravenous Analgesia (PCIA) on Postoperative Delirium in Patients with Liver Transplantation: a Propensity Score Matching Analysis
Authors: Son Hyo Jung , Jeong Ukjin , Choi Kunwoong , Park Ju Yeon , Choi Eun-Ji , Ri Hyun-Su , Lee Tae Beom , Choi Byung Hyun , Choi Yoon Ji
Published: July 2021

Objectives Postoperative opioid use and pain are related to postoperative delirium. This study aims to compare the incidence of delirium in patients with and without patient-controlled intravenous analgesia (PCIA) among liver transplant recipients. Methods The medical records of 253 patients who received liver transplantation (LT) from January 2010 to July 2017 in a single university hospital were retrospectively reviewed. Patients were divided into two groups: the patients who had used PCIA (P group, n = 71) and those who did not use PCIA (C group, n = 182) after LT in intensive care unit (ICU). The patient data were collected, which included demographic data, and details about perioperative management and postoperative complications. Results There was no difference in the model for end-stage liver disease (MELD) score between the two groups. Postoperative delirium occurred in 10 / 71 (14.08 %) in the P group and 26 / 182 (14.29 %) in the C group after LT, respectively (P = 0.97). After propensity score matching, no differences were observed in the incidence of delirium (P = 0.359) and the time from surgery to discharge (P = 0.26) between the two groups. Conclusions Patients with PCIA after LT exhibited no relationship with postoperative delirium. Therefore, it is necessary to actively control postoperative pain using PCIA.
‘In Exile, the Woman Became Everything’
Authors: Sidhva Dina , Zuntz Ann-Christin , al Akash Ruba , Nashwan Ayat , Al-Majali Areej
Published: July 2021

This article explores the intersections of generational and gender dynamics with
humanitarian governance in Jordan that cause shifts in the division of labour
within displaced families. Drawing on life history interviews and focus group
discussions with seventeen Syrian women in Jordan in spring 2019, we explore the
monetary and non-monetary contributions of middle-aged females to the
livelihoods of refugee households. Older women’s paid and unpaid labour
holds together dispersed families whose fathers have been killed or
incapacitated, or remain in Syria or in the Gulf. In doing so, many women draw
on their pre-war experience of living with – or rather apart from
– migrant husbands. Increased economic and social responsibilities
coincide with a phase in our interviewees’ lifecycle in which they
traditionally acquire greater authority as elders, especially as mothers-in-law.
While power inequalities between older and younger Syrian women are not new,
they have been exacerbated by the loss of resources in displacement. Our
insights offer a counterpoint to humanitarian attempts at increasing
refugees’ ‘self-reliance’ through small-scale
entrepreneurship. For now, culturally appropriate and practically feasible jobs
for middle-aged women are found in their living rooms. Supportive humanitarian
action should allow them to upscale their businesses and address power dynamics
within families.
Qualia, (Private) Language and Experience
Authors: Janković Igor
Published: July 2021

The purpose of this paper is to analyze the relationship between qualia and language. Author will begin with the explanation of the nature of qualia using the negative method (second and third chapter), which will reveal that qualia are neither ontological properties in a traditional sense, viewed as instances of subjective experience, nor that they possess any epistemological value as such. In the fourth chapter, qualia will be confronted with language on the grounds of experience which we understand as holistic. Experience as such is not differential, which means it does not contain subject-object relationship in an ontological sense. Afterwards, phenomenologically analyzed, experience will be shown in two modes: pre-personal and personal. Pre-personal experience as unreflective cannot produce a subject-object relationship and as such is a birthplace of qualia as a stimuli-response structure. On the other hand, the possibility of personal experience depends only on consciousness. Consciousness is an active function of experience which produces the subject-object relationship by objectifying the relations between itself and the other. Such objectification is only possible within the boundaries of language which is constituted as a relationship of meanings; which is to say that without meaning there is no object at all. The final conclusion of the paper refers to the bridge connection between qualia and language (pre-personal and personal) which is established by consciousness.
Историја средњовековног света
Authors: Костадиновић-Рачић Александра
Published: July 2021

Прије двије године (2019), издавачка кућа Лагуна из Београда објавила је двотомно дјело Сузан Вајс Бауер (Susan Wise Bauer) под насловом Istorija srednjovekovnog sveta (The History of the Medieval World), које је са енглеског језика превео Дејан Ристић.1 Први том дјела, обима 550 страна, обухвата догађаје од Константинове христијанизације, а завршава се са политичким дјеловањем насљедника пророка Мухамеда, односно описује дешавања у арапском свијету, закључно са шездесетим годинама VII вијека.
Први крсташки рат из угла Византије
Authors: Кречар Стефан
Published: July 2021

Крсташки ратови су се одиграли у раздобљу од краја XI до краја XIII вијека. У том периоду се велики број ратника и свештеника, али и трговаца и обичних људи са простора западне Европе населио у Палестини. Судар двије цивилизације, Истока и Запада, је довео и до успостављања врло важне културне и трговинске размјене. Први крсташки рат представља најуспјешнију епизоду из историје крсташких ратова јер је то био једини поход који је успио да оствари свој главни циљ, а то је ослобођење Јерусалима од муслиманске власти и враћање Свете земље у руке хришћана. Овај поход је уједно донио афирмацију и успон папске моћи, као и ширење утицаја папства на подручје источног Средоземља.
Fire Risk Assessment of Transient Ignition Sources in Domestic Nuclear Power Plants
Authors: Ryu Jung-Hyun
Published: July 2021

The fire risk of a nuclear power plant is evaluated using fixed and transient ignition sources. In terms of the overall fire risk, the proportion of transient ignition sources is very small. However, because the uncertainty due to the difference between the assumptions and the modeling method is relatively large, it is necessary to establish a methodology to address this. In this study, the new transient ignition source evaluation method presented in NUREG/CR-6850, the ignition source frequency revised in NUREG-2169, and the input parameters for transient fire modeling presented in NUREG-2233 were used to evaluate the fire risk assessment for transient ignition sources. In this new evaluation methodology, the fire ignition frequency is quantitatively evaluated based on the characteristics of the area, and an area-based scenario evaluation method considering the location of the transient ignition source is proposed for the evaluation within the area. As a result of applying the new methodology to the switchgear room of a reference nuclear power plant, an approximately 70% risk reduction was confirmed compared to the existing EPRI TR-105928 method. In the future, if fire risk assessment for transient ignition sources in nuclear power plants is applied using the results of this study, it is expected that areas whose control is important in the event of a fire can be determined, which should help reduce highly rated fire risks.
COMPUTER MODELING OF TERRIGENOUS SEDIMENTATION AS A NEW TOOL FOR PREDICTION OF HYDROCARBON RESERVOIR ARCHITECTURE
Authors: Olneva T.V. , Ovechkina V.Yu. , Zhukovskaia ЕE.A.
Published: July 2021

The subject of the article is a new approach based on the integration of seismic facies analysis with modeling of sedimentation system – submarine fan, which is a potential lithological trap. The new approach allows introducing sedimentation systems modeling into the traditional process of seismic data interpretation. The approach was tested on data of the target interval in Cherkashin formation (West Siberia, Priobskoye-Salym region, Neocomian progradation complex). The presence of submarine fans selected as test-subjects for modeling is confirmed by lithofacial analysis, distribution of effective thicknesses over the area according to drilling results, seismic facies analysis. Two criteria were used to evaluate the simulation results: compare the shape of the model with the results of seismic facies analysis and comparison of the parameters describing the geological process and selected in the modeling process with modern data on turbidite systems. Modeling of submarine fan sedimentation was carried out in the Geological Process Modeling (GPM) module of the Petrel software (Schlumberger), Seismic Facies Analysis – in tratimagic software (Emerson). The approach can be recommended for studying of deep-water Achimov deposits; predicting the development of the distal parts of the submarine fan, not evident in the seismic data and predicting the internal architecture of the potential lithological traps.
THE BASIC LAWS OF THE CONCEPT OF PORE SPACE CONNECTEDNESS FOR PETROPHYSICAL MODELING OF RESERVOIR PROPERTIES OF TERRIGENOUS OIL ROCKS
Authors: Belyakov E.O.
Published: July 2021

The paper presents mathematical patterns that allow petrophysical modeling of the basic static and dynamic filtration-capacitive properties of rocks. The considered generalized laws are a mathematical expression of the concept of connected pore space and are obtained on the basis of a general model of effective pore space, based on the results of computer modeling of 3D percolation gratings.
EFFICIENCY EVALUATION OF WATERFLOODING OF LOW-PERMEABILITY RESERVOIRS BY HORIZONTAL WELLS WITH WATER-INJECTION INDUCED FRACTURES
Authors: Bazyrov I.Sh. , Shel E.V , Khasanov M.M.
Published: July 2021

In this paper, semi-analytical model of waterflooding by parallel horizontal wells with transverse water-injection induced fractures has been reviewed for low-permeability reservoirs. The numerical experiments can be divided in following stages: equilibrium pressure of stable water-injection induced fracture existence estimation; evaluation of the critical equilibrium pressure of the injection-induced fractures and estimation of the conditions for the stable fracture growth; evaluation of the critical injection fluid rate for the stable fracture growth; prognosis of the fracture growth dynamics. The main idea of the proposed work is to obtain the conditions of the stable fracture existence. This situation is possible in the late stages of field development, when oil production is compensated by fluid injection, and the pressure distribution does not depend on time. Numerical modeling shows the existence of the critical fracture half-length and pressure, after which the equilibrium of injection-induced fractures becomes unstable. Before this critical fracture length is exceeded, the fracture growth can be controlled by bottomhole pressure and flow rate, since each subcritical length of the equilibrium existence of a fracture corresponds to its equilibrium pressure and flow rate. It is possible to control fracture growth before its unstable state, knowing this pressure and flow rate. The early fracture growth can be estimated by the analytical formula for the fracture half-length in the so-called Carter regime. These results were obtained for specific parameters of the development system, but can be scaled to another homothetic system. The developed model will help to understand the fundamentals of water-injection induced fracture initiation and poroelasticity, as well as develop methods that allow to control and regulate the growth of water-injection induced fractures.
SECONDARY CHANGES IN CARBONATE ROCKS OF OIL AND GAS COMPLEXES
Authors: Tugarova M.A.
Published: July 2021

The article considers the secondary transformations of carbonate rocks of oil and gas complexes, which are of fundamental importance in the formation of reservoir properties. For the first time, a schematic diagram, illustrating the regularities of secondary processes in carbonate reservoirs and their relationship with the physico-chemical conditions of the stratosphere is proposed.
SPARSE APPROXIMATION FOR SEISMIC RESOLUTION INCREASING
Authors: Butorin A.V.
Published: July 2021

One of the important modern tasks in seismic is to increase the resolution of the wave field. In general, the resolution of the wave field estimates as 1/4 wavelengths. At this thickness, the separate interpretation of top and bottom become impossible. There are several algorithms designed to solve the problem of limiting the resolution. These algorithms can include the “whitening” of the frequency spectrum, as well as the use of inversion, which, by taking into account the signal shape, can reduce the influence of interference. In this study, we consider the use of sparse approximation to increase the resolution of the wave field. These algorithms are based on using a given dictionary of wavelets to describe the input seismic path. At the same time, the composition of the dictionary has a significant impact on the result. The article describes the process of forming a dictionary and testing it on model data in order to study the effectiveness of this method.
SPECTRAL INVERSION IS A PROMISING TOOL TO ACCELERATE THE PROJECT
Authors: Fagereva V.A. , Emelianov P.P. , Butorin A.V. , Krasnov F.V. , Oshmarin R.A.
Published: July 2021

This article reveals the possibilities of applying the results of spectral inversion on the example of a field in Eastern Siberia and shows the advantages of this approach over standard methods.
THE SYSTEM OF SUBSTANTIATION OF THE CHOICE OF THE WELL OPERATION METHOD BASED ON THE MATRIX OF APPLICABILITY OF OIL PRODUCTION TECHNOLOGIES
Authors: Kuzmin M.I. , Bublik A.N. , Muzichuk P.S. , Rudnik L.B. , Sushkov A.V. , Nesterenko V.E. , Potapova E.A.
Published: July 2021

An information system is proposed that uses a new complex methodology for choosing a method for well operation based on applicability criteria and boundary conditions for the parameters of mechanized productivity technologies. A mechanism for selecting technologies is presented, which consists of filtering the general register of technologies according to the selected parameters for assessing the total cost of ownership at the Company’s fields. The process of forming and updating the technology base, criteria of applicability and their boundary conditions is considered. Graphic materials illustrate the prototype of this system. The developed methodology will speed up the process of introducing new production technologies, which in turn will lead to a positive economic effect – a decrease in the total cost of ownership of equipment for oil production at the Exploration and Production Block.
Aerogel Spring‐Back Correlates with Strain Recovery: Effect of Silica Concentration and Aging
Authors: Sivaraman Deeptanshu , Zhao Shanyu , Iswar Subramaniam , Lattuada Marco , Malfait Wim J.
Published: July 2021

Silica aerogels display exceptional properties and great application potential, with a mature market in thermal insulation. Both supercritical drying (SCD) and ambient pressure drying (APD) routes are implemented industrially. Herein, how aging and silica content affect the mechanical properties, and how these in turn determine the shrinkage, spring back, and density during APD are systematically investigated. The APD densities display a U‐shaped dependence of density w.r.t. silica concentration. At low silica concentrations, the gels cannot withstand the capillary forces during APD and dense xerogels are obtained. At intermediate to high concentrations, APD shrinkage is strongly reduced and density increases with silica concentration. A series of cylinders are prepared by SCD and investigated by uniaxial compression and their strain recovery is determined systematically. The mechanical responses are plastic, viscoelastic, and brittle in nature for low, intermediate, and high silica concentrations, respectively. The strain recovery of the SCD cylinders correlates to the degree of spring back during APD. The viscoelastic response of SCD aerogels having 6 wt% corresponds to the silica concentration where a minimum in APD aerogel density is observed. The importance of gel mechanics for silica aerogel spring back during APD, in addition to surface modification and hydrophobization is highlighted.
Tuning of Static and Dynamic Mechanical Response of Laser Powder Bed Fused AlSi10Mg Lattice Structures through Heat Treatments
Authors: Fiocchi Jacopo , Bregoli Chiara , Gerosa Giulio , Tuissi Ausonio , Biffi Carlo Alberto
Published: July 2021

The use of additive manufacturing allows the production of complex designs, including metallic lattice structures, which combine lightness and good mechanical properties. Herein, the production of AlSi10Mg lattice structures by laser powder bed fusion is explored and consistent processing parameters are selected. Thereafter, it is demonstrated that heat treatments, specifically designed on the basis of the alloy's metallurgy, can be used to selectively induce different microstructural modifications and, consequently, finely tune the static and dynamic mechanical behavior of the aluminum lattice structures. In particular, removal of residual stresses results to be the dominant factor in allowing a smooth quasistatic compressive behavior and improving the structure's ability to absorb energy during collapse. On the contrary, the increase in ductility connected to the spheroidization of the Si network is shown to be of paramount importance in improving the structure's dynamic damping ability by allowing local plasticization.
Effect of Temperature and Strain Rate on Dynamic Recrystallization of Inconel 617 during Hot Deformation
Authors: Jia Zhi , Yu Lidan , Wei Baolin , Sun Xuan , Wang Yanjiang , Liu Dexue , Ding Yutian
Published: July 2021

Thermostatic compression was performed using a Gleeble‐3500 thermal simulation compressor in the temperature range of 900–1200 °C and strain rate range of 0.001–10 s−1. Use the EBSD (Electron backscatter diffraction) analysis the effects of grain orientation and texture on the DRX of Inconel 617 alloy were analyzed, and the effects of the temperature and strain rate on the recrystallization of Inconel 617 alloy were deduced by the construction of a recrystallization model under these conditions. The results show that the grain orientation and texture are sensitive to the temperature and strain rate changes. Discontinuous dynamic recrystallization (DDRX) events of high‐angle grain boundary migration result in nucleation and growth, and continuous dynamic recrystallization (CDRX) of high‐angle grain boundaries occurs, due to the continuous rotation of subgrains. It was found that DRX occurred before the peak strain, and the ratio of the critical strain to the peak strain is lower than that generally obtained in previous work,due to the influence of twins.
Copper Catalyzed‐TBHP/DTBP Promoted C(sp2)−H Bond Scission of Aldehydes: An Approach to Transform Aldehyde to Esters
Authors: Dagar Neha , Singh Swati , Roy Sudipta Raha
Published: July 2021

The direct oxidative C(sp2)−H functionalization represents a step and atom economical approach for the utilization of aldehyde as promising acyl surrogates. A mild and practical copper catalyzed‐TBHP/DTBP promoted esterification of aldehydes in the presence of alkyl halides and alcohols has been developed. This strategy relies on naturally abundant aldehydes as acyl precursors, which can further couple with readily available alkyl halides/alcohols to transform into esters. Preliminary mechanistic investigations reveal that aldehyde in the presence of tert‐butoxy radical transforms into acyl radical. This protocol exhibits a broad substrate scope along with wide functional group compatibility and is applicable to a wide range of aldehydes, including challenging aliphatic aldehydes to undergo the C(sp2)−H bond scission to furnish the desired esters in good to excellent yields.
Wechselstromelektrolyse als effizientes Instrument für die direkte elektrochemische Oxidation von Hydroxamsäuren für die Acyl‐Nitroso Diels‐Alder‐Reaktion
Authors: Fährmann Jan , Hilt Gerhard
Published: July 2021

Beschrieben wird die Acyl‐Nitroso Diels‐Alder‐Reaktion von 1,3‐Dienen mit elektrochemisch oxidierten Hydroxamsäuren. Durch die Verwendung von Wechselstrom konnte ihr elektro‐induzierter Zerfall zugunsten der 1,2‐Oxazin‐Cycloadditionsprodukte unterdrückt werden. Die Reaktion wurde mittels statistischer Versuchsplanung (Design of Experiment, DoE) optimiert und durch einen Sensitivitätstest weiter untersucht. Ein Gemisch aus Triethylamin und Hexafluorisopropanol dient als Leitsalz in Dichlormethan, wodurch hochreine Produkte nach Verdampfen der flüchtigen Komponenten gewonnen werden können. Mit den optimierten Bedingungen wurden verschiedene 1,3‐Diene und Hydroxamsäuren umgesetzt, deren Produkte in bis zu 96 % Ausbeute isoliert wurden.
PBAT/PLA/cellulose nanocrystals biocomposites compatibilized with polyethylene grafted maleic anhydride (PE‐g‐MA)
Authors: Nunes Fabio Caixeta , Ribeiro Kairin Cristine , Martini Fabio André , Barrioni Breno Rocha , Santos João Paulo Ferreira , Melo Carvalho Benjamim
Published: July 2021

The use of biodegradable polymers has grown exponentially due to their lower environmental impact when compared to conventional polymers. In this sense, biocomposites are an alternative due to their promising properties, maintaining biodegradability. For this purpose, in the present study, a biodegradable biocomposite of PBAT (poly [butylene adipate co‐terephthalate]) and PLA (polylactide) blend containing cellulose nanocrystals (CNC) were obtained, using polyethylene grafted with maleic anhydride (PE‐g‐MA) as a coupling agent. Seven formulations were produced by extrusion and had their structure, morphology, thermal, and rheological properties analyzed. The results showed a significant improvement of adhesion among the components using PE‐g‐MA as a coupling agent. Moreover, CNC and PE‐g‐MA increased the PLA crystallinity degree and reduced the complex viscosity. These results are unprecedented in the literature using these compositions and extrusion processing conditions. Therefore, these new insights provide a vast horizon for the use of biodegradable mixtures using PBAT/PLA and CNC.
PCM nanofibrous composites based on PEG/PVA incorporated by TiO2/Ag nanoparticles for thermal energy management
Authors: Salimian Sadaf , Montazer Majid , Rashidi Abu Saeed , Soleimani Neda , Bashiri Rezaie Ali
Published: July 2021

Herein, form‐stable phase change material fibrous composite containing nanoparticles was prepared via a single‐step green approach using single‐nozzle electrospinning for the first time. Polyethylene glycol (PEG), polyvinyl alcohol (PVA), and water were used as PCM, polymeric support and safe solvent together with simultaneous formation of nanoparticles. The introduced manner not only is free from applying organic solvents, separate addition, or buying nanoparticles and coaxial electrospinning but also it is easy and cost‐effective to use for different applications. Thermal energy storage capacity of the fabricated samples reached to 135.88 and 136.27 J/g in melting process for the nanofibers and nanofibers with nanoparticles, respectively, which are mostly higher than the reported works. Meanwhile supercooling temperature was decreased for (50% PVA/50% PEG/0.1% AgNO3/1% TiO2) nanofibers compared to the other fabricated composites and the pure PEG. The effects of different weight ratio of polymers in spinning solutions, amount of titanium dioxide nanoparticles and silver nitrate, range of phase change transition and thermal endurance and stability of the samples were further discussed in details. Altogether, this renders a single‐step safe route for producing form‐stable PCM nanofibrous composites and also a broad insight concerning the thermal behavior of such composites for diverse renewable energy applications.
Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective PlatinumIV Prodrug Against Triple Negative Breast Cancer
Authors: Muhammad Nafees , Cai‐Ping Tan , Nasreen Sadia , Mao Zong‐Wan
Published: July 2021

A mitochondria targeting dual‐action platinumIV prodrug exhibits high anticancer activity in triple negative breast cancer cells. The complex intervenes in several cellular processes including DNA damage, perturbation of mitochondrial bioenergetics and induction of necrosis to kill cancer cells.
A portable impedance microflow cytometer for measuring cellular response to hypoxia
Authors: Dieujuste Darryl , Qiang Yuhao , Du E.
Published: July 2021

This article presents the development and testing of a low‐cost (<$60), portable, electrical impedance‐based microflow cytometer for single‐cell analysis under a controlled oxygen microenvironment. The system is based on an AD5933 impedance analyzer chip, a microfluidic chip, and an Arduino microcontroller operated by a custom Android application. A representative case study on human red blood cells (RBCs) affected by sickle cell disease is conducted to demonstrate the capability of the cytometry system. Impedance values of sickle blood samples exhibit remarkable deviations from the common reference line obtained from two normal blood samples. Such deviation is quantified by a conformity score, which allows for the measurement of intrapatient and interpatient variations of sickle cell disease. A low conformity score under oxygenated conditions or drastically different conformity scores between oxygenated and deoxygenated conditions can be used to differentiate a sickle blood sample from normal. Furthermore, an equivalent circuit model of a suspended biological cell is used to interpret the electrical impedance of single flowing RBCs. In response to hypoxia treatment, all samples, regardless of disease state, exhibit significant changes in at least one single‐cell electrical property, that is, cytoplasmic resistance and membrane capacitance. The overall response to hypoxia is less in normal cells than those affected by sickle cell disease, where the change in membrane capacitance varies from −23% to seven times as compared with −17% in normal cells. The results reported in this article suggest that the developed method of testing demonstrates the potential application for a low‐cost screening technique for sickle cell disease and other diseases in the field and low‐resource settings. The developed system and methodology can be extended to analyze cellular response to hypoxia in other cell types.
Application of nanoparticles in cancer therapy with an emphasis on cell cycle
Authors: Almanghadim Hossein Ghahramani , Nourollahzadeh Zahra , Khademi Nazanin Sadat , Tezerjani Masoud Dehghan , Sehrig Fatemeh Zeinali , Estelami Neda , Shirvaliloo Milad , Sheervalilou Roghayeh , Sargazi Saman
Published: July 2021

Owing to their unique characteristics, nanoparticles (NPs) could be incorporated into valuable therapeutic modalities for different diseases; however, there are many concerns about risk factors in human applications. NPs carry therapeutic chemicals that could improve the outcome of cancer therapies. Nowadays, NPs are being recognized as important and strategic agents in treatment of several disorders due to their unique properties in targeting malignant cells in tumor sites. Numerous investigations have shown that the majority of chemotherapeutic agents can be modified through entrapment in submicron colloidal systems. Still, there are problems and limitations in application of NPs in cancer therapy. The aim of the present study is to focus on potential NPs usage in cancer treatment with an emphasis on the cell cycle of malignant cells.
Physiologically‐Based Pharmacokinetic Modeling to Support Determination of Bioequivalence for Dermatological Drug Products: Scientific and Regulatory Considerations
Authors: Tsakalozou Eleftheria , Alam Khondoker , Babiskin Andrew , Zhao Liang
Published: July 2021

Physiologically‐based pharmacokinetic (PBPK) modeling and simulation provides mechanism‐based predictions of the pharmacokinetics of an active ingredient following its administration in humans. Dermal PBPK models describe the skin permeation and disposition of the active ingredient following the application of a dermatological product on the skin of virtual healthy and diseased human subjects. These models take into account information on product quality attributes, physicochemical properties of the active ingredient and skin (patho)physiology, and their interplay with each other. Regulatory and product development decision makers can leverage these quantitative tools to identify factors impacting local and systemic exposure. In the realm of generic drug products, the number of US Food and Drug Administratioin (FDA) interactions that use dermal PBPK modeling to support alternative bioequivalence (BE) approaches is increasing. In this report, we share scientific considerations on the development, verification and validation (V&V), and application of PBPK models within the context of a virtual BE assessment for dermatological drug products. We discuss the challenges associated with model V&V for these drug products stemming from the fact that target‐site active ingredient concentrations are typically not measurable. Additionally, there are no established relationships between local and systemic PK profiles, when the latter are quantifiable. To that end, we detail a multilevel model V&V approach involving validation for the model of the drug product of interest coupled with the overall assessment of the modeling platform in use while leveraging in vitro and in vivo data related to local and systemic bioavailability.