bluuebunny/crossref_metadata_2025 huggingface dataset:
Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma
Authors: Fanzani Alessandro , Poli Maura
Published: August 2017

Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation. Different scavenger molecules and detoxifying enzymes, such as glutathione (GSH) and glutathione peroxidase 4 (GPX4), have been shown to overwhelm or exacerbate ferroptosis depending on their expression magnitude. Ferroptosis is emerging as a potential weapon against tumor growth since it has been shown to potentiate cell death in some malignancies. However, this mechanism has been poorly studied in Rhabdomyosarcoma (RMS), a myogenic tumor affecting childhood and adolescence. One of the main drivers of RMS genesis is the Retrovirus Associated DNA Sequences/Extracellular signal Regulated Kinases (RAS/ERK)signaling pathway, the deliberate activation of which correlates with tumor aggressiveness and oxidative stress levels. Since recent studies have indicated that treatment with oxidative inducers can significantly halt RMS tumor progression, in this review we covered different aspects, ranging from iron metabolism in carcinogenesis and tumor growth, to mechanisms of iron-mediated cell death, to highlight the potential role of ferroptosis in counteracting RMS growth.
Teratogenic Effects of Topiramate in a Zebrafish Model
Authors: Lai Yu-Heng , Ding Yu-Ju , Moses David , Chen Yau-Hung
Published: August 2017

Topiramate is commonly used for treating epilepsy in both children and adults. Recent clinical data suggests that administration of topiramate to women during pregnancy increases the risk of oral clefts in their offspring. To better understand the potential effects of topiramate, we dosed adult female zebrafish with topiramate, and investigated the altered morphologies in adult females and their offspring. It showed that topiramate-treated female fish had reduced oocyte maturation, and the survival rates of their offspring were seriously decreased during embryogenesis. In addition, around 23% of offspring displayed cartilage malformation in the craniofacial area, such as loss of ceratobranchial cartilages as well as impaired ceratohyal, Meckel’s cartilage and ethmoid plate development. Moreover, mineralization of ceratohyal, Meckel’s cartilage, and vertebrae were downregulated during bone development. Taken together, we concluded that topiramate impaired oogenesis in the maternal reproductive system, and then caused offspring cartilage malformation or bone dysplasia.
Comparative Studies on Behavioral, Cognitive and Biomolecular Profiling of ICR, C57BL/6 and Its Sub-Strains Suitable for Scopolamine-Induced Amnesic Models
Authors: Karthivashan Govindarajan , Park Shin-Young , Kim Joon-Soo , Cho Duk-Yeon , Ganesan Palanivel , Choi Dong-Kug
Published: August 2017

Cognitive impairment and behavioral disparities are the distinctive baseline features to investigate in most animal models of neurodegenerative disease. However, neuronal complications are multifactorial and demand a suitable animal model to investigate their underlying basal mechanisms. By contrast, the numerous existing neurodegenerative studies have utilized various animal strains, leading to factual disparity. Choosing an optimal mouse strain for preliminary assessment of neuronal complications is therefore imperative. In this study, we systematically compared the behavioral, cognitive, cholinergic, and inflammatory impairments of outbred ICR and inbred C57BL/6 mice strains subject to scopolamine-induced amnesia. We then extended this study to the sub-strains C57BL/6N and C57BL/6J, where in addition to the above-mentioned parameters, their endogenous antioxidant levels and cAMP response-element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) protein expression were also evaluated. Compared with the ICR strain, the scopolamine-inflicted C57BL/6 strains exhibited a substantial reduction of spontaneous alternation and an approximately two-fold increase in inflammatory protein expression, compared to the control group. Among the sub-strains, scopolamine-treated C57BL/6N strains exhibited declined step-through latency, elevated acetylcholinesterase (AChE) activity and inflammatory protein expression, associated with reduced endogenous antioxidant levels and p-CREB/BDNF expression, compared to the control and tacrine-treated groups. This indicates that the C57BL/6N strains exhibit significantly enhanced scopolamine-induced neuronal impairment compared to the other evaluated strains.
Fungal Pigments: Deep into the Rainbow of Colorful Fungi
Authors: Dufossé Laurent , Caro Yanis , Fouillaud Mireille
Published: August 2017

With the impact of globalization on research trends, the search for healthier life styles, the increasing public demand for natural, organic, and ”clean labelled” products, as well as the growing global market for natural colorants in economically fast-growing countries all over the world, filamentous fungi started to be investigated as readily available sources of chemically diverse pigments and colorants.[...]
Global Hedging through Post-Decision State Variables
Authors: Breton Michèle , Godin Frédéric
Published: August 2017

Unlike delta-hedging or similar methods based on Greeks, global hedging is an approach that optimizes some terminal criterion that depends on the difference between the value of a derivative security and that of its hedging portfolio at maturity or exercise. Global hedging methods in discrete time can be implemented using dynamic programming. They provide optimal strategies at all rebalancing dates for all possible states of the world, and can easily accommodate transaction fees and other frictions. However, considering transaction fees in the dynamic programming model requires the inclusion of an additional state variable, which translates into a significant increase of the computational burden. In this short note, we show how a decomposition technique based on the concept of post-decision state variables can be used to reduce the complexity of the computations to the level of a problem without transaction fees. The latter complexity reduction allows for substantial gains in terms of computing time and should therefore contribute to increasing the applicability of global hedging schemes in practice where the timely execution of portfolio rebalancing trades is crucial.
320-nm Flexible Solution-Processed 2,7-dioctyl[1] benzothieno[3,2-b]benzothiophene Transistors
Authors: Ren Hang , Tang Qingxin , Tong Yanhong , Liu Yichun
Published: August 2017

Flexible organic thin-film transistors (OTFTs) have received extensive attention due to their outstanding advantages such as light weight, low cost, flexibility, large-area fabrication, and compatibility with solution-processed techniques. However, compared with a rigid substrate, it still remains a challenge to obtain good device performance by directly depositing solution-processed organic semiconductors onto an ultrathin plastic substrate. In this work, ultrathin flexible OTFTs are successfully fabricated based on spin-coated 2,7-dioctyl[1]benzothieno[3,2-b]benzothiophene (C8-BTBT) films. The resulting device thickness is only ~320 nm, so the device has the ability to adhere well to a three-dimension curved surface. The ultrathin C8-BTBT OTFTs exhibit a mobility as high as 4.36 cm2 V−1 s−1 and an on/off current ratio of over 106. These results indicate the substantial promise of our ultrathin flexible C8-BTBT OTFTs for next-generation flexible and conformal electronic devices.
The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK
Authors: Boccitto Marco , Lee Nayoung , Sakamoto Satoshi , Spruce Lynn , Handa Hiroshi , Clardy Jon , Seeholzer Steven , Kalb Robert
Published: August 2017

In previous work, we characterized the strong neuroprotective properties of the marine compound Psammaplysene A (PA) in in vitro and in vivo models of neurodegeneration. Based on its strong neuroprotective activity, the current work attempts to identify the physical target of PA to gain mechanistic insight into its molecular action. Two distinct methods, used in parallel, to purify protein-binding partners of PA led to the identification of HNRNPK as a direct target of PA. Based on surface plasmon resonance, we find that the binding of PA to HNRNPK is RNA-dependent. These findings suggest a role for HNRNPK-dependent processes in neurodegeneration/neuroprotection, and warrant further study of HNRNPK in this context.
Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function
Authors: Zininga Tawanda , Anokwuru Chinedu , Sigidi Muendi , Tshisikhawe Milingoni , Ramaite Isaiah , Traoré Afsatou , Hoppe Heinrich , Shonhai Addmore , Potgieter Natasha
Published: August 2017

Malaria parasites are increasingly becoming resistant to currently used antimalarial therapies, therefore there is an urgent need to expand the arsenal of alternative antimalarial drugs. In addition, it is also important to identify novel antimalarial drug targets. In the current study, extracts of two plants, Pterocarpus angolensis and Ziziphus mucronata were obtained and their antimalarial functions were investigated. Furthermore, we explored the capability of the extracts to inhibit Plasmodium falciparum heat shock protein 70 (Hsp70) function. Heat shock protein 70 (Hsp70) are molecular chaperones whose function is to facilitate protein folding. Plasmodium falciparum the main agent of malaria, expresses two cytosol-localized Hsp70s: PfHsp70-1 and PfHsp70-z. The PfHsp70-z has been reported to be essential for parasite survival, while inhibition of PfHsp70-1 function leads to parasite death. Hence both PfHsp70-1 and PfHsp70-z are potential antimalarial drug targets. Extracts of P. angolensis and Z. mucronata inhibited the basal ATPase and chaperone functions of the two parasite Hsp70s. Furthermore, fractions of P. angolensis and Z. mucronata inhibited P. falciparum 3D7 parasite growth in vitro. The extracts obtained in the current study exhibited antiplasmodial activity as they killed P. falciparum parasites maintained in vitro. In addition, the findings further suggest that some of the compounds in P. angolensis and Z. mucronata may target parasite Hsp70 function.
Optimization of the Ultrasound-Assisted Extraction of Phenolic Compounds from Brosimum alicastrum Leaves and the Evaluation of Their Radical-Scavenging Activity
Authors: Gullian Klanian Mariel , Terrats Preciat Montserrat
Published: August 2017

In order to maximize the yield of the total phenolic content (TPC) and total monomeric anthocyanin (TMA) from Brosimum alicastrum leaf and to study the radical-scavenging activity, a three-level three-factor Box–Behnken design (BBD) was used to determine the optimal points for ultrasound-assisted extraction (UAE). In this study, we analyzed the extraction time (10, 20, and 30 min), temperature (28, 30, and 32 °C), and probe sonication power (40%, 28 W/cm2; 60%, 51 W/cm2; and 80%, 74 W/cm2). Analysis of variance (ANOVA) indicated that the sonication power plays a significant role in the extraction of phenolic compounds. An increase in time and temperature resulted in a decrease in the yield, in particular, of the TMA group. DPPH was found to be a better indicator of radical-scavenging activity than ABTS. The predicted TPC and TMA optimum levels (45.18 mg GAE/g and 15.16 mg CyE/100 g) were obtained at 28 °C, 80%, and 20–10 min. DPPH obtained a maximum value (67.27 μmol TE/g) under same optimization conditions. The RSM confirmed that TPC and TMA enhanced the antioxidant activity when subjected to low temperature (28 °C), extraction time less than 20 min, and higher sonication power (74 W/cm2), and hence achieving the better DPPH scavenging activity.
Characterization of Proanthocyanidin Oligomers of Ephedra sinica
Authors: Orejola Joanna , Matsuo Yosuke , Saito Yoshinori , Tanaka Takashi
Published: August 2017

Ephedra sinica, an important plant in Chinese traditional medicine, contains a complex mixture of proanthocyanidin oligomers as major constituents; however, only the minor components have been chemically characterized. In this study, oligomers with relatively large molecular weights, which form the main body of the proanthocyanidin fractions, were separated by adsorption and size-exclusion chromatography. Acid-catalyzed degradation in the presence of mercaptoethanol or phloroglucinol led to the isolation of 18 fragments, the structures of which were elucidated from their experimental and TDDFT-calculated ECD spectra. The results indicated that (−)-epigallocatechin was the main extension unit, while catechin, the A-type epigallocatechin–gallocatechin dimer, and the A-type epigallocatechin homodimer, were identified as the terminal units. Among the degradation products, thioethers of gallocatechin with 3,4-cis configurations, a B-type prodelphinidin dimer, a prodelphinidin trimer with both A- and B-type linkages, and a prodelphinidin dimer with an α-substituted A-type linkage were new compounds. In addition, a phloroglucinol adduct of an A-type prodelphinidin dimer, a doubly-linked phloroglucinol adduct of epigallocatechin, and a unique product with a flavan-3-ol skeleton generated by the rearrangement of the aromatic rings were also isolated.
Cytotoxic and Antiviral Triterpenoids from the Mangrove Plant Sonneratia paracaseolaris
Authors: Gong Kai-Kai , Li Ping-Lin , Qiao Dan , Zhang Xing-Wang , Chu Mei-Jun , Qin Guo-Fei , Tang Xu-Li , Li Guo-Qiang
Published: August 2017

A chemical investigation was conducted on the aerial parts of the mangrove plant Sonneratia paracaseolaris, yielding five new triterpenoid paracaseolins A–E (1–4, and 11) together with twelve known analogues (5–10, 12–17). Their structures were established by extensive spectroscopic methods and comparisons their spectroscopic data with those of the known related compounds. The cytotoxicities against P388, HeLa, A549, and K562 tumor cell lines and anti-H1N1 (Influenza A virus) activities for the isolates were evaluated. Compound 4 showed potent cytotoxicity against the A549 cell line with an IC50 value of 1.89 µM, and compound 1 exhibited significant anti-H1N1 virus activity with an IC50 value of 28.4 µg/mL. A preliminary structure activity relationship was discussed.
Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System
Authors: Proudfoot Amanda , Johnson Zoë , Bonvin Pauline , Handel Tracy
Published: August 2017

Chemokines have two types of interactions that function cooperatively to control cell migration. Chemokine receptors on migrating cells integrate signals initiated upon chemokine binding to promote cell movement. Interactions with glycosaminoglycans (GAGs) localize chemokines on and near cell surfaces and the extracellular matrix to provide direction to the cell movement. The matrix of interacting chemokine–receptor partners has been known for some time, precise signaling and trafficking properties of many chemokine–receptor pairs have been characterized, and recent structural information has revealed atomic level detail on chemokine–receptor recognition and activation. However, precise knowledge of the interactions of chemokines with GAGs has lagged far behind such that a single paradigm of GAG presentation on surfaces is generally applied to all chemokines. This review summarizes accumulating evidence which suggests that there is a great deal of diversity and specificity in these interactions, that GAG interactions help fine-tune the function of chemokines, and that GAGs have other roles in chemokine biology beyond localization and surface presentation. This suggests that chemokine–GAG interactions add complexity to the already complex functions of the receptors and ligands.
Pharmacists’ Attitudes and Perceived Barriers to Human Papillomavirus (HPV) Vaccination Services
Authors: Hastings Tessa , Hohmann Lindsey , McFarland Stuart , Teeter Benjamin , Westrick Salisa
Published: August 2017

Use of non-traditional settings such as community pharmacies has been suggested to increase human papillomavirus (HPV) vaccination uptake and completion rates. The objectives of this study were to explore HPV vaccination services and strategies employed by pharmacies to increase HPV vaccine uptake, pharmacists’ attitudes towards the HPV vaccine, and pharmacists’ perceived barriers to providing HPV vaccination services in community pharmacies. A pre-piloted mail survey was sent to 350 randomly selected community pharmacies in Alabama in 2014. Measures included types of vaccines administered and marketing/recommendation strategies, pharmacists’ attitudes towards the HPV vaccine, and perceived system and parental barriers. Data analysis largely took the form of descriptive statistics. 154 pharmacists completed the survey (response rate = 44%). The majority believed vaccination is the best protection against cervical cancer (85.3%), HPV is a serious threat to health for girls (78.8%) and boys (55.6%), and children should not wait until they are sexually active to be vaccinated (80.1%). Perceived system barriers included insufficient patient demand (56.5%), insurance plans not covering vaccination cost (54.8%), and vaccine expiration before use (54.1%). Respondents also perceived parents to have inadequate education and understanding about HPV infection (86.6%) and vaccine safety (78.7%). Pharmacists have positive perceptions regarding the HPV vaccine. Barriers related to system factors and perceived parental concerns must be overcome to increase pharmacist involvement in HPV vaccinations.
Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD)
Authors: Abdul Rehman Saad , Khurshid Zohaib , Hussain Niazi Fayez , Naseem Mustafa , Al Waddani Hamed , Sahibzada Haafsa , Sannam Khan Rabia
Published: August 2017

Human whole mouth saliva (WMS) is secreted by salivary glands, namely parotid, submandibular/sublingual and other minor glands of the oral cavity. It is secreted in a systematic way, and contain informative proteins and peptides for the early detection of contagious diseases and organ-related diseases. The role of WMS as a liquid biopsy for the detection of cardiovascular diseases (CVD) through Myoglobin (MYO), Cardiac troponin I (cTnI), Creatine phosphokinase MB (CK-MB), Myeloperoxidase (MPO), brain natriuretic peptide (NT-proBNP), Exosomal miRNA, C-Reactive Protein (CRP), Matrix metalloproteinase-8 (MMP-8), MMP-9 and tissue inhibitor of MMP-8 (TIMP-1), leukotriene B4 has been well reported in last decade, that have been reviewed in the literature comprehensively below.
The Qur’an’s Message on Spirituality and Martyrdom: A Literary and Rhetorical Analysis
Authors: Arya Nisha
Published: August 2017

Is the Qur’an a spiritual text that links human existence to divine benevolence? Or does the Qur’an advocate martyrdom and justify violence against non-believers? This debate acquired new urgency with the rise of terrorism perpetrated in the name of Islam in the later decades of the twentieth century. On the one hand, the Qur’an provides spiritual guidance to millions of Muslims around the world. On the other, Islamic terrorist organizations draw inspiration from the Qur’an. Some Western experts also cite Qur’anic passages as supporting violence and terrorism. This paper interprets the Qur’an in the tradition of Arab scholars of the early medieval period (eighth century CE) who began al-balāgha, a study of literary devices used in the rhetorical expression of the Qur’an. The paper analyzes how literary and rhetorical elements in the Qur’an have shaped its message on man’s relationship with the divine, as well as two key theological concepts in Islam: requital and final judgment. The paper demonstrates how an appreciation of the Qur’an’s literary and rhetorical elements is critical to understanding its spiritual message, as well as its stance on violence and martyrdom.
Image Fusion-Based Land Cover Change Detection Using Multi-Temporal High-Resolution Satellite Images
Authors: Wang Biao , Choi Jaewan , Choi Seokeun , Lee Soungki , Wu Penghai , Gao Yan
Published: August 2017

Change detection is usually treated as a problem of explicitly detecting land cover transitions in satellite images obtained at different times, and helps with emergency response and government management. This study presents an unsupervised change detection method based on the image fusion of multi-temporal images. The main objective of this study is to improve the accuracy of unsupervised change detection from high-resolution multi-temporal images. Our method effectively reduces change detection errors, since spatial displacement and spectral differences between multi-temporal images are evaluated. To this end, a total of four cross-fused images are generated with multi-temporal images, and the iteratively reweighted multivariate alteration detection (IR-MAD) method—a measure for the spectral distortion of change information—is applied to the fused images. In this experiment, the land cover change maps were extracted using multi-temporal IKONOS-2, WorldView-3, and GF-1 satellite images. The effectiveness of the proposed method compared with other unsupervised change detection methods is demonstrated through experimentation. The proposed method achieved an overall accuracy of 80.51% and 97.87% for cases 1 and 2, respectively. Moreover, the proposed method performed better when differentiating the water area from the vegetation area compared to the existing change detection methods. Although the water area beneath moderate and sparse vegetation canopy was captured, vegetation cover and paved regions of the water body were the main sources of omission error, and commission errors occurred primarily in pixels of mixed land use and along the water body edge. Nevertheless, the proposed method, in conjunction with high-resolution satellite imagery, offers a robust and flexible approach to land cover change mapping that requires no ancillary data for rapid implementation.
A New Method to Estimate Changes in Glacier Surface Elevation Based on Polynomial Fitting of Sparse ICESat—GLAS Footprints
Authors: Huang Tianjin , Jia Li , Menenti Massimo , Lu Jing , Zhou Jie , Hu Guangcheng
Published: August 2017

We present in this paper a polynomial fitting method applicable to segments of footprints measured by the Geoscience Laser Altimeter System (GLAS) to estimate glacier thickness change. Our modification makes the method applicable to complex topography, such as a large mountain glacier. After a full analysis of the planar fitting method to characterize errors of estimates due to complex topography, we developed an improved fitting method by adjusting a binary polynomial surface to local topography. The improved method and the planar fitting method were tested on the accumulation areas of the Naimona’nyi glacier and Yanong glacier on along-track facets with lengths of 1000 m, 1500 m, 2000 m, and 2500 m, respectively. The results show that the improved method gives more reliable estimates of changes in elevation than planar fitting. The improved method was also tested on Guliya glacier with a large and relatively flat area and the Chasku Muba glacier with very complex topography. The results in these test sites demonstrate that the improved method can give estimates of glacier thickness change on glaciers with a large area and a complex topography. Additionally, the improved method based on GLAS Data and Shuttle Radar Topography Mission-Digital Elevation Model (SRTM-DEM) can give estimates of glacier thickness change from 2000 to 2008/2009, since it takes the 2000 SRTM-DEM as a reference, which is a longer period than 2004 to 2008/2009, when using the GLAS data only and the planar fitting method.
A Study of Thermistor Performance within a Textile Structure
Authors: Hughes-Riley Theodore , Lugoda Pasindu , Dias Tilak , Trabi Christophe , Morris Robert
Published: August 2017

Textiles provide an ideal structure for embedding sensors for medical devices. Skin temperature measurement is one area in which a sensor textile could be particularly beneficial; pathological skin is normally very sensitive, making the comfort of anything placed on that skin paramount. Skin temperature is an important parameter to measure for a number of medical applications, including for the early detection of diabetic foot ulcer formation. To this end an electronic temperature-sensor yarn was developed by embedding a commercially available thermistor chip into the fibres of a yarn, which can be used to produce a textile or a garment. As part of this process a resin was used to encapsulate the thermistor. This protects the thermistor from mechanical and chemical stresses, and also allows the sensing yarn to be washed. Building off preliminary work, the behaviour and performance of an encapsulated thermistor has been characterised to determine the effect of encapsulation on the step response time and absolute temperature measurements. Over the temperature range of interest only a minimal effect was observed, with step response times varying between 0.01–0.35 s. A general solution is presented for the heat transfer coefficient compared to size of the micro-pod formed by the encapsulation of the thermistor. Finally, a prototype temperature-sensing sock was produced using a network of sensing yarns as a demonstrator of a system that could warn of impending ulcer formation in diabetic patients.
Electrospinning Hetero-Nanofibers In2O3/SnO2 of Homotype Heterojunction with High Gas Sensing Activity
Authors: Du Haiying , Yao PengJun , Sun Yanhui , Wang Jing , Wang Huisheng , Yu Naisen
Published: August 2017

In2O3/SnO2 composite hetero-nanofibers were synthesized by an electrospinning technique for detecting indoor volatile organic gases. The physical and chemical properties of In2O3/SnO2 hetero-nanofibers were characterized and analyzed by X-ray diffraction (XRD), field emission scanning electron microscope (FE-SEM), Energy Dispersive X-Ray Spectroscopy (EDX), specific surface Brunauer–Emmett–Teller (BET) and X-ray photoelectron spectroscopy (XPS). Gas sensing properties of In2O3/SnO2 composite hetero-nanofibers were measured with six kinds of indoor volatile organic gases in concentration range of 0.5~50 ppm at the operating temperature of 275 °C. The In2O3/SnO2 composite hetero-nanofibers sensor exhibited good formaldehyde sensing properties, which would be attributed to the formation of n-n homotype heterojunction in the In2O3/SnO2 composite hetero-nanofibers. Finally, the sensing mechanism of the In2O3/SnO2 composite hetero-nanofibers was analyzed based on the energy-band principle.
Estimation and Validation of Energy Consumption in UK Existing Hotel Building Using Dynamic Simulation Software
Authors: Rotimi Abdulazeez , Bahadori-Jahromi Ali , Mylona Anastasia , Godfrey Paulina , Cook Darren
Published: August 2017

Adverse effects of anthropogenic climate change has resulted in mitigation strategies geared towards curbing CO2 emissions. Consequently, this has increased demand for more energy efficient buildings. Considerable amounts of studies have shown the existence of a significant discrepancy between estimated energy consumption by thermal simulation software and actual building operational energy; this is referred to as a ‘performance gap’. This work presents a method of improving the energy consumption estimate in an existing non-domestic building via the use of a case study UK hotel (Hilton Reading Hotel) and Engineering Development Solutions limited (EDSL) TAS thermal simulation software. The method involves evaluating consumption estimates through plant modelling, and modifying this result by surveying the site to verify the simulation data and including estimates of unaccounted building energy use such as catering services which can be significant in hotels. The energy consumption result for this case study building gives an estimate which is within 12% of the actual building consumption data. The result also demonstrated that such models can produce energy consumption estimates that are up to 23% more accurate than building regulation compliance models and that more accurate simulation consumption estimates can be achieved by accounting for more unregulated energy uses, for example, lifts, servers and small power load.
Planning Resilient and Sustainable Cities: Identifying and Targeting Social Vulnerability to Climate Change
Authors: Ge Yi , Dou Wen , Liu Ning
Published: August 2017

This research offers a new framework for assessing social vulnerability to climate change. A social vulnerability assessment trial was carried out for Chinese coastal cities at the county level. First, the 10 factors having the most influence on social vulnerability were identified. They are “House with no lavatory”, “House with no bath facilities”, “Employees in primary industry”, “Houses with no tap water”, “GDP in primary sector”, “Children”, “House with no kitchen”, “Rate of natural increase (RNI), “Employees in management sector”, and “Highly educated”. Second, indexes of social vulnerability, exposure, sensitivity, and adaptability were evaluated and mapped to examine their spatial pattern. The results demonstrate that the distribution of exposure index (EI) is similar to that of social vulnerability index (SVI): many counties are categorized at the medium level while a few counties belong to the high or low categories. The distribution of adaptability proves that it should be paid more attention, as 30.14% of its counties belong to the lowest level. After calculating the Getis-Ord Gi* statistic of SVI, two cold spots and two hot spots are identified. Third, the relationship between urban development and social vulnerability are discussed. During urbanization, there are evident differences of SVI between urban and rural areas. Urbanization can help city districts reduce social vulnerability, while creating more social vulnerability in the coastal counties. For the districts, more adjustment strategies and work should be applied in the dimension of exposure during urbanization. For the counties, the prominent problem to be faced is an increase in sensitivity.
Effects of Emotional Valence on Hemispheric Asymmetries in Response Inhibition
Authors: Ocklenburg Sebastian , Peterburs Jutta , Mertzen Janet , Schmitz Judith , Güntürkün Onur , Grimshaw Gina
Published: August 2017

Hemispheric asymmetries are a major organizational principle in human emotion processing, but their interaction with prefrontal control processes is not well understood. To this end, we determined whether hemispheric differences in response inhibition depend on the emotional valence of the stimulus being inhibited. Participants completed a lateralised Go/Nogo task, in which Nogo stimuli were neutral or emotional (either positive or negative) images, while Go stimuli were scrambled versions of the same pictures. We recorded the N2 and P3 event-related potential (ERP) components, two common electrophysiological measures of response inhibition processes. Behaviourally, participants were more accurate in withholding responses to emotional than to neutral stimuli. Electrophysiologically, Nogo-P3 responses were greater for emotional than for neutral stimuli, an effect driven primarily by an enhanced response to positive images. Hemispheric asymmetries were also observed, with greater Nogo-P3 following left versus right visual field stimuli. However, the visual field effect did not interact with emotion. We therefore find no evidence that emotion-related asymmetries affect response inhibition processes.
Hybrid Second-Order Iterative Algorithm for Orthogonal Projection onto a Parametric Surface
Authors: Li Xiaowu , Wang Lin , Wu Zhinan , Hou Linke , Liang Juan , Li Qiaoyang
Published: August 2017

To compute the minimum distance between a point and a parametric surface, three well-known first-order algorithms have been proposed by Hartmann (1999), Hoschek, et al. (1993) and Hu, et al. (2000) (hereafter, the First-Order method). In this paper, we prove the method’s first-order convergence and its independence of the initial value. We also give some numerical examples to illustrate its faster convergence than the existing methods. For some special cases where the First-Order method does not converge, we combine it with Newton’s second-order iterative method to present the hybrid second-order algorithm. Our method essentially exploits hybrid iteration, thus it performs very well with a second-order convergence, it is faster than the existing methods and it is independent of the initial value. Some numerical examples confirm our conclusion.
North Carolina Toxic Substance Incidents Program 2010–2015: Identifying Areas for Injury Prevention Efforts
Authors: Eiffert Samantha , Etienne Suze , Hirsch Annie , Langley Ricky
Published: August 2017

The National Toxic Substance Incidents Program (NTSIP) is a surveillance system designed to capture acute toxic substance releases, factors contributing to the release, and any associated injuries. North Carolina has participated since 2010, when NTSIP was established. This article will present a descriptive statistical summary from 2010 to 2015 focused on releases that resulted in injuries in order to identify areas for public health prevention efforts. Of the 1690 toxic releases in North Carolina, 155 incidents resulted in injuries and 500 people were injured. Carbon monoxide injured the greatest number of people. Of the incidents that resulted in injuries, 68 occurred at private vehicles or residences (44%), injuring 124 people (25%). Over half of events where at least one responder was injured occurred at private vehicles or residences. Events occurring at private residences did not have a significant relationship between evacuations and injuries, while for industry-related events, the odds of an evacuation being ordered were 8.18 times greater (OR = 8.18, 95% CI = 5.19, 12.89) when there were injuries associated with an event. Intervention efforts should focus on preventing responder injuries while responding to private residence releases and educating the general public on how to prevent injuries by self-evacuating areas where hazardous chemicals have been released.
Neglected Tropical Diseases: Epidemiology and Global Burden
Authors: Mitra Amal , Mawson Anthony
Published: August 2017

More than a billion people—one-sixth of the world’s population, mostly in developing countries—are infected with one or more of the neglected tropical diseases (NTDs). Several national and international programs (e.g., the World Health Organization’s Global NTD Programs, the Centers for Disease Control and Prevention’s Global NTD Program, the United States Global Health Initiative, the United States Agency for International Development’s NTD Program, and others) are focusing on NTDs, and fighting to control or eliminate them. This review identifies the risk factors of major NTDs, and describes the global burden of the diseases in terms of disability-adjusted life years (DALYs).
Onset of a Large Ejective Solar Eruption from a Typical Coronal-jet-base Field Configuration
Authors: Joshi Navin Chandra , Sterling Alphonse C. , Moore Ronald L. , Magara Tetsuya , Moon Yong-Jae
Published: August 2017

Utilizing multiwavelength observations and magnetic field data from the Solar Dynamics Observatory (SDO)/Atmospheric Imaging Assembly (AIA), SDO/Helioseismic and Magnetic Imager (HMI), the Geostationary Operational Environmental Satellite (GOES), and RHESSI, we investigate a large-scale ejective solar eruption of 2014 December 18 from active region NOAA 12241. This event produced a distinctive “three-ribbon” flare, having two parallel ribbons corresponding to the ribbons of a standard two-ribbon flare, and a larger-scale third quasi-circular ribbon offset from the other two. There are two components to this eruptive event. First, a flux rope forms above a strong-field polarity inversion line and erupts and grows as the parallel ribbons turn on, grow, and spread apart from that polarity inversion line; this evolution is consistent with the mechanism of tether-cutting reconnection for eruptions. Second, the eruption of the arcade that has the erupting flux rope in its core undergoes magnetic reconnection at the null point of a fan dome that envelops the erupting arcade, resulting in formation of the quasi-circular ribbon; this is consistent with the breakout reconnection mechanism for eruptions. We find that the parallel ribbons begin well before (∼12 minutes) the onset of the circular ribbon, indicating that tether-cutting reconnection (or a non-ideal MHD instability) initiated this event, rather than breakout reconnection. The overall setup for this large-scale eruption (diameter of the circular ribbon ∼105 km) is analogous to that of coronal jets (base size ∼104 km), many of which, according to recent findings, result from eruptions of small-scale “minifilaments.” Thus these findings confirm that eruptions of sheared-core magnetic arcades seated in fan–spine null-point magnetic topology happen on a wide range of size scales on the Sun.
Magnetically Induced Disk Winds and Transport in the HL Tau Disk
Authors: Hasegawa Yasuhiro , Okuzumi Satoshi , Flock Mario , Turner Neal J.
Published: August 2017

The mechanism of angular momentum transport in protoplanetary disks is fundamental to understanding the distributions of gas and dust in the disks. The unprecedented ALMA observations taken toward HL Tau at high spatial resolution and subsequent radiative transfer modeling reveal that a high degree of dust settling is currently achieved in the outer part of the HL Tau disk. Previous observations, however, suggest a high disk accretion rate onto the central star. This configuration is not necessarily intuitive in the framework of the conventional viscous disk model, since efficient accretion generally requires a high level of turbulence, which can suppress dust settling considerably. We develop a simplified, semi-analytical disk model to examine under what condition these two properties can be realized in a single model. Recent, non-ideal MHD simulations are utilized to realistically model the angular momentum transport both radially via MHD turbulence and vertically via magnetically induced disk winds. We find that the HL Tau disk configuration can be reproduced well when disk winds are properly taken into account. While the resulting disk properties are likely consistent with other observational results, such an ideal situation can be established only if the plasma β at the disk midplane is β
0 ≃ 2 × 104 under the assumption of steady accretion. Equivalently, the vertical magnetic flux at 100 au is about 0.2 mG. More detailed modeling is needed to fully identify the origin of the disk accretion and quantitatively examine plausible mechanisms behind the observed gap structures in the HL Tau disk.
The Molecular Cloud S242: Physical Environment and Star-formation Activities
Authors: Dewangan L. K. , Baug T. , Ojha D. K. , Janardhan P. , Devaraj R. , Luna A.
Published: August 2017

We present a multi-wavelength study to probe the star-formation (SF) processes on a larger scale (

) around the S242 site. The S242 molecular cloud is depicted in a velocity range from −3.25 to 4.55 km s−1 and has a spatially elongated appearance. Based on the virial analysis, the cloud is prone to gravitational collapse. The cloud harbors an elongated filamentary structure (EFS; length ∼25 pc), which is evident in the Herschel column density map, and the EFS has an observed mass per unit length of ∼200

pc−1, exceeding the critical value of ∼16

pc−1 (at T = 10 K). The EFS contains a chain of Herschel clumps (M
clump ∼ 150–1020

), revealing the evidence of fragmentation along its length. The most massive clumps are observed at both the EFS ends, while the S242 H ii region is located at one EFS end. Based on the radio continuum maps at 1.28 and 1.4 GHz, the S242 H ii region is ionized by a B0.5V–B0V type star and has a dynamical age of ∼0.5 Myr. The photometric 1–5 μm data analysis of point-like sources traces young stellar objects (YSOs) toward the EFS and the clusters of YSOs are exclusively found at both the EFS ends, revealing the SF activities. Considering the spatial presence of massive clumps and YSO clusters at both the EFS ends, the observed results are consistent with the prediction of an SF scenario of the end-dominated collapse driven by the higher acceleration of gas.
Simultaneous Monitoring of X-Ray and Radio Variability in Sagittarius A*
Authors: Capellupo Daniel M. , Haggard Daryl , Choux Nicolas , Baganoff Fred , Bower Geoffrey C. , Cotton Bill , Degenaar Nathalie , Dexter Jason , Falcke Heino , Fragile P. Chris , Heinke Craig O. , Law Casey J. , Markoff Sera , Neilsen Joey , Ponti Gabriele , Rea Nanda , Yusef-Zadeh Farhad
Published: August 2017

Monitoring of Sagittarius A* from X-ray to radio wavelengths has revealed structured variability—including X-ray flares—but it is challenging to establish correlations between them. Most studies have focused on variability in the X-ray and infrared, where variations are often simultaneous, and because long time series at submillimeter and radio wavelengths are limited. Previous work on submillimeter and radio variability hints at a lag between X-ray flares and their candidate submillimeter or radio counterparts, with the long wavelength data lagging the X-ray. However, there is only one published time lag between an X-ray flare and a possible radio counterpart. Here we report nine contemporaneous X-ray and radio observations of Sgr A*. We detect significant radio variability peaking

minutes after the brightest X-ray flare ever detected from Sgr A*. We also report other potentially associated X-ray and radio variability, with the radio peaks appearing

minutes after these weaker X-ray flares. Taken at face value, these results suggest that stronger X-ray flares lead to longer time lags in the radio. However, we also test the possibility that the variability at X-ray and radio wavelengths is not temporally correlated. We cross-correlate data from mismatched X-ray and radio epochs and obtain comparable correlations to the matched data. Hence, we find no overall statistical evidence that X-ray flares and radio variability are correlated, underscoring a need for more simultaneous, long duration X-ray–radio monitoring of Sgr A*.
Robust Cross-correlation-based Measurement of Clump Sizes in Galaxies
Authors: Ali Kamran , Obreschkow Danail , Fisher David B. , Glazebrook Karl , Damjanov Ivana , Abraham Roberto G. , Bassett Robert
Published: August 2017

Stars form in molecular complexes that are visible as giant clouds (

) in nearby galaxies and as giant clumps (

) in galaxies at redshifts

–3. Theoretical inferences on the origin and evolution of these complexes often require robust measurements of their characteristic size, which is hard to measure at limited resolution and often ill-defined due to overlap and quasi-fractal substructure. We show that maximum and luminosity-weighted sizes of clumps seen in star formation maps (e.g., Hα) can be recovered statistically using the two-point correlation function (2PCF) if an approximate stellar surface density map is taken as the normalizing random field. After clarifying the link between Gaussian clumps and the 2PCF analytically, we design a method for measuring the diameters of Gaussian clumps with realistic quasi-fractal substructure. This method is tested using mock images of clumpy disk galaxies at different spatial resolutions and perturbed by Gaussian white noise. We find that the 2PCF can recover the input clump scale at

accuracy, as long as this scale is larger than the spatial resolution. We apply this method to the local spiral galaxy NGC 5194, as well as to three clumpy turbulent galaxies from the DYNAMO-HST sample. In both cases, our statistical measurements of Hα clump size agree with previous measurements and with the estimated Jeans lengths. However, the new measurements are free from subjective choices when fitting individual clumps.
Effects of H2SO4 Content on Electrochemical Activation of Etched Tunnels on Aluminum Foil
Authors: Peng Ning , He Yedong , Yang Hong
Published: August 2017

Electrochemical behavior of aluminum foil in H2SO4 solutions was intensively studied. Because of the antagonistic effect of and H+ contained in H2SO4, the surface etching of the aluminum foil in the H2SO4 solution gradually increased with the H2SO4 concentration. When HCl was added to the H2SO4 solution, the surface etching of the aluminum foil became dependent on the H2SO4 concentration. The increased H2SO4 concentration reduced the pitting resistance of the aluminum foil, thus improving the distribution uniformity of the etched tunnels. The decreased tunnel length was analyzed by using an electrochemical process.
Corrosion and Stress Corrosion Cracking Susceptibility of Type 347H Stainless Steel in Supercritical Water
Authors: Guo Xianglong , Gao Wenhua , Chen Kai , Shen Zhao , Zhang Lefu
Published: August 2017

The corrosion resistance and stress corrosion cracking (SCC) susceptibility of Type 347H stainless steel (SS) in supercritical water (SCW) were investigated. The general corrosion behavior was investigated by exposure test and the specimens after testing were characterized utilizing scanning electron microscopy (SEM), Auger and x-ray diffraction analysis, optical microscopy, and energy dispersive spectroscopy (EDS). The results show that with the increase of testing temperature, the corrosion rate of the materials is greatly enhanced. The corrosion process is analyzed and the formation of oxide islands on the surface of the corroded sample is attributed to the higher diffusion rate of Cr along the grain boundary. The effects of temperature and dissolved oxygen on SCC susceptibility were investigated by slow strain rate tensile test. The fractographs were characterized by SEM and the cross-section morphologies were characterized with back-scattered electron imaging, SEM, and EDS. The results indicate that, as temperature is increased, the tensile strength and strain of materials is greatly reduced, while the oxygen content in SCW has a limited effect on the mechanical properties. Intergranular cracking and ductile fracture are the main fracture modes for Type 347H SS tested in SCW, independent of temperature and oxygen content. The implications of the results to the mechanisms of SCC are discussed.