bluuebunny/crossref_metadata_2025 huggingface dataset:
μSR Study of Unconventional Pairing Symmetry in the Quasi-1D Na2Cr3As3 Superconductor
Authors: Bhattacharyya Amitava , Adroja Devashibhai , Feng Yu , Das Debarchan , Biswas Pabitra Kumar , Das Tanmoy , Zhao Jun
Published: March 2023

We report the finding of a novel pairing state in a newly discovered superconductor Na2Cr3As3. This material has a non-centrosymmetric quasi-one-dimensional crystal structure and is superconducting at TC∼ 8.0 K. We find that the magnetic penetration depth data suggests the presence of a nodal line pz-wave pairing state with zero magnetic moment using transverse-field muon-spin rotation (TF-μSR) measurements. The nodal gap observed in Na2Cr3As3 compound is consistent with that observed in isostructural (K,Cs)2Cr3As3 compounds using TF-μSR measurements. The observed pairing state is consistent with a three-band model spin-fluctuation calculation, which reveals the Sz=0 spin-triplet pairing state with the sinkz pairing symmetry. The long-sought search for chiral superconductivity with topological applications could be aided by such a novel triplet Sz=0p-wave pairing state.
Properties of Coordinated h1,h2-Convex Functions of Two Variables Related to the Hermite–Hadamard–Fejér Type Inequalities
Authors: Latif Muhammad Amer
Published: March 2023

In this paper, we prove the Hermite–Hadamard–Fejér type inequalities for coordinated h1,h2-convex functions on the rectangle from the plane R2. Some generalizations of the Hermite–Hadamard-type inequalities of two variables are also obtained as a consequence. Some properties of two functionals which are connected with the coordinated h1,h2-convex functions are provided as well. Finally, we give applications of the acquired results to special means of positive real numbers.
A New Loss Function for Simultaneous Object Localization and Classification
Authors: Sanchez-Chica Ander , Ugartemendia-Telleria Beñat , Zulueta Ekaitz , Fernandez-Gamiz Unai , Gomez-Hidalgo Javier Maria
Published: March 2023

Robots play a pivotal role in the manufacturing industry. This has led to the development of computer vision. Since AlexNet won ILSVRC, convolutional neural networks (CNNs) have achieved state-of-the-art status in this area. In this work, a novel method is proposed to simultaneously detect and predict the localization of objects using a custom loop method and a CNN, performing two of the most important tasks in computer vision with a single method. Two different loss functions are proposed to evaluate the method and compare the results. The obtained results show that the network is able to perform both tasks accurately, classifying images correctly and locating objects precisely. Regarding the loss functions, when the target classification values are computed, the network performs better in the localization task. Following this work, improvements are expected to be made in the localization task of networks by refining the training processes of the networks and loss functions.
Interview: Kalyanmoy Deb Talks about Formation, Development and Challenges of the EMO Community, Important Positions in His Career, and Issues Faced Getting His Works Published
Authors: Coello Carlos , Goodman Erik , Miettinen Kaisa , Saxena Dhish , Schütze Oliver , Thiele Lothar
Published: March 2023

Kalyanmoy Deb was born in Udaipur, Tripura, the smallest state of India at the time, in 1963 [...]
The Effect of the Rotating Disk Geometry on the Flow and Flux Enhancement in a Dynamic Filtration System
Authors: Park Jo Eun , Kang Tae Gon , Moon Heejang
Published: March 2023

A numerical study was conducted to investigate the effect of rotating patterned disks on the flow and permeate flux in a dynamic filtration (DF) system. The DF system consists of a rotating patterned disk and a stationary housing with a circular flat membrane. The feed flow is driven by the rotating disk with the angular velocity ranging from 200 to 1000 rpm and the applied pressure difference between inlet and outlet ports. Wheel-shaped patterns are engraved on the disk surfaces to add perturbation to the flow field and improve the permeate flux in the filtration system. Five disks with varying numbers of patterns were used in numerical simulations to examine the effects of the number of patterns and the angular velocity of the disk on the flow and permeate flux in the DF system. The flow characteristics are studied using the velocity profiles, the cross-sectional velocity vectors, the vortex structures, and the shear stress distribution. The wheel-shaped patterns shift the central core layer in the circumferential velocity profile towards the membrane, leading to higher shear stresses at the membrane and higher flux compared to a plain disk. When the number of patterns on the disk exceeded eight at a fixed Reynolds number, there were significant increases in wall shear stress and permeate flux compared to a plain disk filtration system with no pattern.
Preparation of Tannic Acid/Hyaluronic Acid Coating to Improve the Corrosion Resistance of Implant Material Based on AZ31B Magnesium Alloy
Authors: Salsabila Aurelia , Pratama Aditya , Nurrochman Andrieanto , Hermawan Hendra , Barlian Anggraini , Prajatelistia Ekavianty
Published: March 2023

Magnesium (Mg) has good biocompatibility, making it suitable as an implant material. However, Mg has a high corrosion rate because of the reaction between magnesium implants and fluids in the human body. To lower the corrosion rate of magnesium alloys, it is necessary to perform a coating process using tannic acid (TA) and hyaluronic acid (HYA), as we have done in this study. TA, an active ingredient, is relatively inexpensive, easy to find, and can effectively reduce the degradation rate. SEM characterization showed that the TA–HYA layer was formed by chelation between the Mg and TA surfaces. Furthermore, adding HYA to the coating covered the cracks caused by the TA layer and increased the hydrophilic properties. In vitro corrosion tests using Tafel polarization showed that the TA–HYA coating reduced the corrosion rate of the magnesium alloy from 7.379 mm/year to 0.204 mm/year. The immersion test in the SBF solution showed that the TA–HYA layer could bind Mg2+, which is beneficial for new bone growth.
Novel Low Power Cross-Coupled FET-Based Sense Amplifier Design for High-Speed SRAM Circuits
Authors: Priya G. Lakshmi , Saran Puneet , Padhy Shikhar Kumar , Agarwal Prateek , Andrew Roobert A. , Julus L. Jerart
Published: March 2023

We live in a technologically advanced society where we all use semiconductor chips in the majority of our gadgets, and the basic criterion concerning data storage and memory is a small footprint and low power consumption. SRAM is a very important part of this and can be used to meet all the above criteria. In this study, LTSpice software is used to come up with a high-performance sense amplifier circuit for low-power SRAM applications. Throughout this research, various power reduction approaches were explored, and the optimal solution has been implemented in our own modified SRAM design. In this article, the effect of power consumption and the reaction time of the suggested sense amplifier were also examined by adjusting the width-to-length (W/L) ratio of the transistor, the power supply, and the nanoscale technology. The exact amount of power used and the number of transistors required by different approaches to better comprehend the ideal technique are also provided. Our proposed design of a low-power sense amplifier has shown promising results, and we employ three variations of VLSI power reduction techniques to improve efficiency. Low-power SRAMs embrace the future of memory-centric neuromorphic computing applications.
Effects of Voids on Thermal Fatigue Reliability of Solder Joints on Inner Rings in Ball Grid Array Packaging by Finite Element Analysis
Authors: Hu Xingwang , Liu Li , Liu Sheng , Ruan Meng , Chen Zhiwen
Published: March 2023

Under alternating temperatures, the fatigue failure of solder balls caused by the mismatch of the thermal expansion coefficient is a key problem in a Ball Grid Array (BGA). However, the combined effects of the solder ball location and the size of voids within it can seriously affect the thermal fatigue reliability of BGA solder balls, which can be easily ignored by researchers. Firstly, the thermal fatigue reliability of the board-level solder balls was evaluated by a temperature cycling test of the BGA package at −20 °C–+125 °C. The experimental results showed that the thermal fatigue reliability of the outer ring’s solder joint was lower than that of the inner ring. Secondly, the reliability of the solder balls in the BGA package was studied under the same thermal cycling condition based on finite element analysis (FEA). The influences of voids on fatigue life were investigated. Generally, a linear correlation between the void content and the fatigue life of the inner rings’ solder balls could be identified with a gradually smoothed relationship for solder balls closer to the center. In addition, when the size of the void exceeded a critical volume, the inner ring’s solder ball with the void would fail before the outermost ring. The results of FEA showed that the critical void volume ratio from the second to fifth ring increased from 10.5% to 42.3%. This study provides a valuable reference for the influence of voids on the thermal fatigue reliability of BGA solder balls.
Nanoparticle Coatings on Glass Surfaces to Prevent Pseudomonas fluorescens AR 11 Biofilm Formation
Authors: Marra Daniele , Perna Irene , Pota Giulio , Vitiello Giuseppe , Pezzella Alessandro , Toscano Giuseppe , Luciani Giuseppina , Caserta Sergio
Published: March 2023

Microbial colonization of surfaces is a sanitary and industrial issue for many applications, leading to product contamination and human infections. When microorganisms closely interact with a surface, they start to produce an exo-polysaccaridic matrix to adhere to and protect themselves from adverse environmental conditions. This type of structure is called a biofilm. The aim of our work is to investigate novel technologies able to prevent biofilm formation by surface coatings. We coated glass surfaces with melanin-ZnO2, melanin-TiO2, and TiO2 hybrid nanoparticles. The functionalization was performed using cold plasma to activate glass-substrate-coated surfaces, that were characterized by performing water and soybean oil wetting tests. A quantitative characterization of the antibiofilm properties was done using Pseudomonas fluorescens AR 11 as a model organism. Biofilm morphologies were observed using confocal laser scanning microscopy and image analysis techniques were used to obtain quantitative morphological parameters. The results highlight the efficacy of the proposed surface coating to prevent biofilm formation. Melanin-TiO2 proved to be the most efficient among the particles investigated. Our results can be a valuable support for future implementation of the technique proposed here in an extended range of applications that may include further testing on other strains and other support materials.
Evaluation of an Artificial Mouth for Dental Caries Development
Authors: Amaechi Bennett T. , Abdul Azees Parveez Ahamed , Farah Rayane , Movaghari Pour Fatemeh , Dillow Andrew M. , Lin Chun-Yen
Published: March 2023

This study validated a microbial caries model (artificial mouth) for dental caries development to determine the optimal time to create early caries suitable for evaluation of the efficacy of caries therapeutic agents. In all, 40 human enamel blocks were placed in an artificial mouth at 37 °C and 5% CO2 and were exposed to brain heart infusion broth inoculated with S. mutans in continuous circulation (0.3 mL/min). The culture medium was replaced three times daily. Samples were exposed to 10% sucrose for 3 min, 3 times daily to promote biofilm growth. Five samples were harvested from the chamber after 3, 4, 5, 6, 7, 14, 21, and 28 days. At the end of experiment, samples were assessed visually by ICDAS criteria, while lesion depth (LD) and mineral loss (ML) were measured using polarizing light microscopy and transverse microradiography. Data were analyzed by Pearson correlation, ANOVA, and Tukey comparison test (p < 0.05). Results showed significant and strong positive correlation (p < 0.01) between all variables and biofilm growth time. LD and ML profiles of 7-day lesions seem to be the most suitable for remineralization studies. In conclusion, using the evaluated artificial mouth, early-stage caries suitable for products’ evaluation studies was produced within 7 days of exposure to microbial biofilm.
Influence of Extremely High Pressure and Oxygen on Hydrocarbon-Enriched Microbial Communities in Sediments from the Challenger Deep, Mariana Trench
Authors: Liu Ying , Chen Songze , Xie Zhe , Zhang Li , Wang Jiahua , Fang Jiasong
Published: March 2023

Recent studies reported that highly abundant alkane content exists in the ~11,000 m sediment of the Mariana Trench, and a few key alkane-degrading bacteria were identified in the Mariana Trench. At present, most of the studies on microbes for degrading hydrocarbons were performed mainly at atmospheric pressure (0.1 MPa) and room temperature; little is known about which microbes could be enriched with the addition of n-alkanes under in-situ environmental pressure and temperature conditions in the hadal zone. In this study, we conducted microbial enrichments of sediment from the Mariana Trench with short-chain (SCAs, C7–C17) or long-chain (LCAs, C18–C36) n-alkanes and incubated them at 0.1 MPa/100 MPa and 4 °C under aerobic or anaerobic conditions for 150 days. Microbial diversity analysis showed that a higher microbial diversity was observed at 100 MPa than at 0.1 MPa, irrespective of whether SCAs or LCAs were added. Non-metric multidimensional scaling (nMDS) and hierarchical cluster analysis revealed that different microbial clusters were formed according to hydrostatic pressure and oxygen. Significantly different microbial communities were formed according to pressure or oxygen (p < 0.05). For example, Gammaproteobacteria (Thalassolituus) were the most abundant anaerobic n-alkanes-enriched microbes at 0.1 MPa, whereas the microbial communities shifted to dominance by Gammaproteobacteria (Idiomarina, Halomonas, and Methylophaga) and Bacteroidetes (Arenibacter) at 100 MPa. Compared to the anaerobic treatments, Actinobacteria (Microbacterium) and Alphaproteobacteria (Sulfitobacter and Phenylobacterium) were the most abundant groups with the addition of hydrocarbon under aerobic conditions at 100 MPa. Our results revealed that unique n-alkane-enriched microorganisms were present in the deepest sediment of the Mariana Trench, which may imply that extremely high hydrostatic pressure (100 MPa) and oxygen dramatically affected the processes of microbial-mediated alkane utilization.
Editorial for the Special Issue “Bio-Geochemistry of Heavy Metals/Metalloids”
Authors: Megremi Ifigeneia , Economou-Eliopoulos Maria
Published: March 2023

This Special Issue “Bio-Geochemistry of Heavy Metals/Metalloids” contains a series of papers that cover a range of topics highlighting the role of microorganisms in ore-forming biochemical processes and potential environmental risk (the first to fourth papers), in the assessment of potentially toxic element contamination using plants and living benthic Foraminifera (the fifth and sixth papers), and in the phytoremediation of contaminated land (the seventh paper) [...]
Geochemical Assessment of River Sediments at the Outlets of Eastern Makran, Pakistan; Implications for Source Area Weathering and Provenance
Authors: Khan Waseem , Zhang Ke , Liang Hao , Yu Pengpeng
Published: March 2023

The river sediments in the eastern Makran were investigated to determine the influence of climate, tectonics, and source rocks based on the geochemistry of sediment delivery to the offshore marine basin. Samples were collected at the outlets of four major drainage basins. The specimens were analyzed by XRF, ICP–MS, and ICP–AES. The geochemical concentrations of major, trace, and rare earth elements show great variation among the four outlets. The Rakhshan Kaur (RK), Shadi Kaur (SK), and Dasht Kaur (DK) represent more sorted and matured detrital sediments than those of the Hingol Kaur (HK). The detrital sediments at all outlets represent mostly humid climates except for the DK which falls at the junction of humid and semi-arid conditions. The studied samples show a low level of source area weathering. The sedimentary provenance of the RK and DK is due to the heterogeneous sources of detritus from Iran in the west and the older Eocene-Holocene sedimentary successions in the east. The sediment carried by SK is probably from the late Oligocene–Holocene succession from central and coastal Makran. The HK represents a heterogeneous provenance from the Kirthar-Sulaiman Belt, Bela Ophiolites, and sedimentary successions of central and coastal Makran. The tectonic environments of all river sediments signify a continental arc rather than an active continental margin.
Staphylococcus aureus Behavior on Artificial Surfaces Mimicking Bone Environment
Authors: Lemaire Anaïs , Varin-Simon Jennifer , Lamret Fabien , Dubus Marie , Kerdjoudj Halima , Velard Frédéric , Gangloff Sophie C. , Reffuveille Fany
Published: March 2023

Infections, which interfere with bone regeneration, may be a critical issue to consider during the development of biomimetic material. Calcium phosphate (CaP) and type I collagen substrates, both suitable for bone-regeneration dedicated scaffolds, may favor bacterial adhesion. Staphylococcus aureus possesses adhesins that allow binding to CaP or collagen. After their adhesion, bacteria may develop structures highly tolerant to immune system attacks or antibiotic treatments: the biofilms. Thus, the choice of material used for scaffolds intended for bone sites is essential to provide devices with the ability to prevent bone and joint infections by limiting bacterial adhesion. In this study, we compared the adhesion of three different S. aureus strains (CIP 53.154, SH1000, and USA300) on collagen- and CaP-coating. Our objective was to evaluate the capacity of bacteria to adhere to these different bone-mimicking coated supports to better control the risk of infection. The three strains were able to adhere to CaP and collagen. The visible matrix components were more important on CaP- than on collagen-coating. However, this difference was not reflected in biofilm gene expression for which no change was observed between the two tested surfaces. Another objective was to evaluate these bone-mimicking coatings for the development of an in vitro model. Thus, CaP, collagen-coatings, and the titanium-mimicking prosthesis were simultaneously tested in the same bacterial culture. No significant differences were found compared to adhesion on surfaces independently tested. In conclusion, these coatings used as bone substitutes can easily be colonized by bacteria, especially CaP-coating, and must be used with an addition of antimicrobial molecules or strategies to avoid bacterial biofilm development.
Dendrimer-Mediated Delivery of Anticancer Drugs for Colon Cancer Treatment
Authors: Rai Divya Bharti , Medicherla Kanakaraju , Pooja Deep , Kulhari Hitesh
Published: March 2023

The third most common cancer worldwide is colon cancer (CC). Every year, there more cases are reported, yet there are not enough effective treatments. This emphasizes the need for new drug delivery strategies to increase the success rate and reduce side effects. Recently, a lot of trials have been done for developing natural and synthetic medicines for CC, among which the nanoparticle-based approach is the most trending. Dendrimers are one of the most utilized nanomaterials that are accessible and offer several benefits in the chemotherapy-based treatment of CC by improving the stability, solubility, and bioavailability of drugs. They are highly branched polymers, making it simple to conjugate and encapsulate medicines. Dendrimers have nanoscale features that enable the differentiation of inherent metabolic disparities between cancer cells and healthy cells, enabling the passive targeting of CC. Moreover, dendrimer surfaces can be easily functionalized to improve the specificity and enable active targeting of colon cancer. Therefore, dendrimers can be explored as smart nanocarriers for CC chemotherapy.
Development of Robust Tablet Formulations with Enhanced Drug Dissolution Profiles from Centrifugally-Spun Micro-Fibrous Solid Dispersions of Itraconazole, a BCS Class II Drug
Authors: Marano Stefania , Ghimire Manish , Missaghi Shahrzad , Rajabi-Siahboomi Ali , Craig Duncan Q. M. , Barker Susan A.
Published: March 2023

Fibre-based oral drug delivery systems are an attractive approach to addressing low drug solubility, although clear strategies for incorporating such systems into viable dosage forms have not yet been demonstrated. The present study extends our previous work on drug-loaded sucrose microfibres produced by centrifugal melt spinning to examine systems with high drug loading and investigates their incorporation into realistic tablet formulations. Itraconazole, a model BCS Class II hydrophobic drug, was incorporated into sucrose microfibres at 10, 20, 30, and 50% w/w. Microfibres were exposed to high relative humidity conditions (25 °C/75% RH) for 30 days to deliberately induce sucrose recrystallisation and collapse of the fibrous structure into powdery particles. The collapsed particles were successfully processed into pharmaceutically acceptable tablets using a dry mixing and direct compression approach. The dissolution advantage of the fresh microfibres was maintained and even enhanced after humidity treatment for drug loadings up to 30% w/w and, importantly, retained after compression into tablets. Variations in excipient content and compression force allowed manipulation of the disintegration rate and drug content of the tablets. This then permitted control of the rate of supersaturation generation, allowing the optimisation of the formulation in terms of its dissolution profile. In conclusion, the microfibre-tablet approach has been shown to be a viable method for formulating poorly soluble BCS Class II drugs with improved dissolution performance.
Pulse Measurement from a Polluted Frequency Resolved Optical Gating Trace Based on Half-Trace Retrieval Algorithm
Authors: Pan Liangze , Ouyang Xiaoping , Zhang Xuejie , Liu Cheng , Zhu Jianqiang
Published: March 2023

A half-trace retrieval algorithm based on an extended-ptychographical iterative engine algorithm is proposed to reconstruct the temporal structure of pulse from a polluted and recorded frequency-resolved optical gating (FROG) trace that was modulated by poor spatial profile of output pulses, stray light, or misalignment of the measurement setup. In the proposed algorithm, the probe pulse and the gated pulse were retrieved simultaneously from a recorded FROG trace with a half-delay range, and the measured pulse was obtained by combining the different edges of the probe pulse and the gated pulse. Numerical simulations were carried out to verify the feasibility of the proposed algorithm. A single-shot picoseconds (ps)−THG−FROG setup with a 100-μJ ps laser system and an online ps−SHG−FROG setup in PW laser system were built to test the proposed algorithm experimentally. The results show that the temporal structure of pulses retrieved by the half-trace retrieval algorithm is closer to the real temporal structure than that retrieved by the conventional ptychographical algorithm when the recorded FROG trace is badly polluted.
Nanotubes in Chitin Mode Locker for Passive Mode−Locked Fibre Laser in 2.0 µm Region
Authors: Mohamad Rashid Nur Nadhirah , Ahmad Harith , Ismail Mohammad Faizal , Lokman Muhammad Quisar , Zuikafly Siti Nur Fatin , Yahaya Hafizal , Nordin Nur Azmah , Wan Nawawi Wan Mohd Fazli , Ahmad Fauzan
Published: March 2023

This research demonstrated an ultrafast passively mode-locked thulium-holmium doped fibre laser (THDFL) using a carbon nanotube (CNT)-chitin composite film as a saturable absorber (SA). The CNTs were fabricated using ultrasonic-assisted liquid-phase exfoliation, and the chitin biopolymer was derived from oyster mushrooms (Pleurotus Ostreatus). The free-standing SA successfully performed a mode-locking operation at a threshold input pump power of 203 mW with an operating wavelength of 1908.53 nm. The generated mode-locked pulses had repetition rate, pulse width, and signal-to-noise ratio (SNR) values of 16 MHz, 1.1 ps, and 69 dB, respectively. The work demonstrates the potential of CNTs embedded in chitin biopolymer as a sustainable and environmentally friendly SA for a wide range of applications, particularly for pulsed lasers.
Optimum Design of Glass–Air Disordered Optical Fiber with Two Different Element Sizes
Authors: Zhao Jiajia , He Changbang , Luo Haimei , Zhao Yali , Mao Yiyu , Cai Wangyang
Published: March 2023

This paper presents a detailed study investigating the effect of the material refractive index distribution at the local position of a glass–air disordered optical fiber (G-DOF) on its localized beam radius. It was found that the larger the proportion of the glass material, the smaller its localized beam radius, which means that the transverse Anderson localization (TAL) effect would be stronger. Accordingly, we propose a novel G-DOF with large-size glass elements doped in the fiber cross-section. The simulation results show that the doped large-size glass elements can reduce the localized beam radius in the doped region and has a very tiny effect on the undoped region, thus contributing to reducing the average localized beam radius of G-DOF.
The Acceleration Phenomenon of Shock Wave Induced by Nanosecond Laser Irradiating Silicon Assisted by Millisecond Laser
Authors: Li Jingyi , Zhang Wei , Li Ye , Jin Guangyong
Published: March 2023

The propagating evolution of shock waves induced by a nanosecond pulse laser (ns laser) irradiating silicon assisted by a millisecond pulse laser (ms laser) is investigated experimentally. A numerical model of 2D axisymmetric two-phase flow is established to obtain the spatial distribution of shock wave velocity. Two types of shock wave acceleration phenomenon are found. The mechanism of the shock wave acceleration phenomenon is discussed. The experimental and numerical results show that the initial stage of ms laser-induced plasma can provide the initial ions to increase probability of collision ionization between free electrons and vapor atoms. The velocity of the ns laser-induced shock wave is accelerated. Furthermore, the ms laser-induced plasma as the propagation medium can also accelerate the ns laser-induced shock wave. The shock wave acceleration methods obtained in this paper can promote the development of laser propulsion technology.
Inverse Saturable Absorption Mechanism in Mode-Locked Fiber Lasers with a Nonlinear Amplifying Loop Mirror
Authors: Zhang Xiang , Shen Yong , Tang Xiaokang , Liu Qu , Zou Hongxin
Published: March 2023

From the perspective of the differential phase delay experienced by the two counterpropagating optical fields, the self-starting of the mode-locked fiber laser with a non-linear amplifying loop mirror (NALM) is theoretically studied. Although it is generally believed that NALM shows a saturable absorption effect on both continuous wave (CW) light and pulses, we find a counter-intuitive fact that cross-phase modulation (XPM) leads to opposite signs of differential non-linear phase shifts (NPSs) in these two cases, resulting in inverse saturable absorption (ISA) during the pulse formation process. The ISA is not helpful for the self-starting of laser mode-locking and can be alleviated by introducing a non-reciprocal phase shifter into the fiber loop. These results are helpful for optimizing the design of NALM and lowering the self-starting threshold of the high-repetition-rate mode-locked fiber laser.
Carpological Analysis of Two Endemic Italian Species: Pimpinella anisoides and Pimpinella gussonei (Apiaceae)
Authors: Laface Valentina Lucia Astrid , Musarella Carmelo Maria , Tavilla Gianmarco , Cambria Salvatore , Maruca Gina , Giusso del Galdo Gianpietro , Spampinato Giovanni
Published: March 2023

This study aims to clarify the taxonomic doubts, which have varied over the centuries, on the only two endemic species of the genus Pimpinella growing in Italy: P. anisoides and P. gussonei. For this purpose, the main carpological characters of the two species were examined, analyzing the external morphological traits and their cross-sections. Fourteen morphological traits were identified, obtaining datasets for the two groups using 40 mericarps (20 per species). The obtained measurements were subjected to statistical analysis (MANOVA and PCA). Our results highlight that at least 10 of the 14 morphological traits analyzed support the distinction between P. anisoides and P. gussonei. In particular, the following carpological characters are very significant ways to distinguish between the two species: monocarp width and length (Mw, Ml), monocarp length from base to maximum width (Mm), stylopodium width and length (Sw, Sl), length/width ratio (l/w) and cross-section area (CSa). In particular, the fruit of P. anisoides is larger (Mw 1.61 ± 0.10 mm) than that of P. gussonei (Mw 1.27 ± 0.13 mm), the mericarps of the first species are longer (Ml 3.14 ± 0.32 vs. 2.26 ± 0.18 mm) and the cross-section area (CSa) of P. gussonei is larger (0.92 ± 0.19 mm) than that of P. anisoides (0.69 ± 0.12 mm). The results also highlight the importance of the morphological traits of the carpological structures for the specific discrimination of similar species. The findings of this study contribute to an evaluation of the taxonomic significance of this species within the genus Pimpinella, and also provide valuable information for the conservation of these two endemic species.
Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential
Authors: Shinu Pottathil , Gupta Girdhari Lal , Sharma Manu , Khan Shahzad , Goyal Manoj , Nair Anroop B. , Kumar Manish , Soliman Wafaa E. , Rahman Aminur , Attimarad Mahesh , Venugopala Katharigatta N. , Altaweel Abdullah Abdulhamid Ahmed
Published: March 2023

Glycyrrhiza glabra L. (belonging to the family Leguminosae), commonly known as Licorice, is a popular medicinal plant that has been used in traditional medicine worldwide for its ethnopharmacological efficacy in treating several ailments. Natural herbal substances with strong biological activity have recently received much attention. The main metabolite of glycyrrhizic acid is 18β-glycyrrhetinic acid (18βGA), a pentacyclic triterpene. A major active plant component derived from licorice root, 18βGA has sparked a lot of attention due to its pharmacological properties. The current review thoroughly examines the literature on 18βGA, a major active plant component obtained from Glycyrrhiza glabra L. The current work provides insight into the pharmacological activities of 18βGA and the potential mechanisms of action involved. The plant contains a variety of phytoconstituents such as 18βGA, which has a variety of biological effects including antiasthmatic, hepatoprotective, anticancer, nephroprotective, antidiabetic, antileishmanial, antiviral, antibacterial, antipsoriasis, antiosteoporosis, antiepileptic, antiarrhythmic, and anti-inflammatory, and is also useful in the management of pulmonary arterial hypertension, antipsychotic-induced hyperprolactinemia, and cerebral ischemia. This review examines research on the pharmacological characteristics of 18βGA throughout recent decades to demonstrate its therapeutic potential and any gaps that may exist, presenting possibilities for future drug research and development.
Preparation of Immobilised 17β-Estradiol-Imprinted Nanoparticles onto Bacterial Cellulose Nanofibres to Use for the Removal of 17β-Estradiol from Wastewater
Authors: Koç İlker , Şarkaya Koray , Türkmen Deniz , Aşır Süleyman , Denizli Adil
Published: March 2023

Estradiol, a phenolic steroid oestrogen, is one of the endocrine-disrupting chemicals (EDCs) found in natural and tap waters. The detection and removal of EDCs is attracting attention daily as they negatively affect animals’ and humans’ endocrine functions and physiological conditions. Therefore, developing a fast and practical method for the selective removal of EDCs from waters is essential. In this study, we prepared 17β-estradiol (E2)-imprinted HEMA-based nanoparticles onto bacterial cellulose nanofibres (E2-NP/BC-NFs) to use for the removal of E2 from wastewater. FT-IR and NMR confirmed the structure of the functional monomer. The composite system was characterised by BET, SEM, µCT, contact angle, and swelling tests. Additionally, the non-imprinted bacterial cellulose nanofibres (NIP/BC-NFs) were prepared to compare the results of E2-NP/BC-NFs. Adsorption of E2 from aqueous solutions was performed in batch mode and investigated via several parameters for optimisation conditions. The effect of pH studies was examined in the 4.0–8.0 range using acetate and phosphate buffers and a concentration of E2 of 0.5 mg/mL. The maximum E2 adsorption amount was 254 µg/g phosphate buffer at 45 °C. The experimental data show that the Langmuir is a relevant isotherm model for E2 adsorption. Additionally, the relevant kinetic model was the pseudo-second-order kinetic model. It was observed that the adsorption process reached equilibrium in less than 20 min. The E2 adsorption decreased with the increase in salt at varying salt concentrations. The selectivity studies were performed using cholesterol and stigmasterol as competing steroids. The results show that E2 is 46.0 times more selective than cholesterol and 21.0 times more selective than stigmasterol. According to the results, the relative selectivity coefficients for E2/cholesterol and E2/stigmasterol were 8.38 and 86.6 times greater for E2-NP/BC-NFs than for E2-NP/BC-NFs, respectively. The synthesised composite systems were repeated ten times to assess the reusability of E2-NP/BC-NFs.
The Effect of Various Environmental Conditions on the Impact Damage Behaviour of Natural-Fibre-Reinforced Composites (NFRCs)—A Critical Review
Authors: Musthaq Muneer Ahmed. , Dhakal Hom Nath , Zhang Zhongyi , Barouni Antigoni , Zahari Rizal
Published: March 2023

Studies into environmental conditions and their effects on the properties of renewable materials are gaining significant attention in the research field, particularly for natural fibres and their resultant composites. However, natural fibres are prone to water absorption because of the hydrophilic nature of the fibres, which affects the overall mechanical properties of natural-fibre-reinforced composites (NFRCs). In addition, NFRCs are based mainly on thermoplastic and thermosetting matrices, which could be used in automobile and aerospace components as lightweight materials. Therefore, such components have to survive the maximum temperature and humid conditions in different parts of the world. Based on the above factors, through an up-to-date review, this paper critically discusses the effects of environmental conditions on the impact performance of NFRCs. In addition, this paper critically assesses the damage mechanisms of NFRCs and their hybrids by focusing more on moisture ingress and relative humidity in the impact damage behaviour of NFRCs.
Antimicrobial and Antiviral Properties of Triclosan-Containing Polymer Composite: Aging Effects of pH, UV, and Sunlight Exposure
Authors: Tauanov Zhandos , Zakiruly Olzhas , Baimenova Zhuldyz , Baimenov Alzhan , Akimbekov Nuraly S. , Berillo Dmitriy
Published: March 2023

The present study deals with the synthesis and characterization of a polymer composite based on an unsaturated ester loaded with 5 wt.% triclosan, produced by co-mixing on an automated hardware system. The polymer composite’s non-porous structure and chemical composition make it an ideal material for surface disinfection and antimicrobial protection. According to the findings, the polymer composite effectively inhibited (100%) the growth of Staphylococcus aureus 6538-P under exposure to physicochemical factors, including pH, UV, and sunlight, over a 2-month period. In addition, the polymer composite demonstrated potent antiviral activity against human influenza virus strain A and the avian coronavirus infectious bronchitis virus (IBV), with infectious activities of 99.99% and 90%, respectively. Thus, the resulting triclosan-loaded polymer composite is revealed to have a high potential as a surface-coating non-porous material with antimicrobial properties.
Transfer of AgNPs’ Anti-Biofilm Activity into the Nontoxic Polymer Matrix
Authors: Mačák Lívia , Velgosova Oksana , Múdra Erika , Vojtko Marek , Dolinská Silvia
Published: March 2023

A biological method was successfully applied to synthesize spherical silver nanoparticles (AgNPs) while using the extract of lavender (Ex-L) (lat. Lavandula angustifolia) as the reducing and stabilizing agent. The produced nanoparticles were spherical with an average size of 20 nm. The AgNPs’ synthesis rate confirmed the extract’s excellent ability to reduce silver nanoparticles from the AgNO3 solution. The presence of good stabilizing agents was confirmed by the excellent stability of the extract. Nanoparticles’ shapes and sizes did not change. UV-Vis absorption spectrometry, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) were used to characterize the silver nanoparticles. The silver nanoparticles were incorporated into the PVA polymer matrix by the “ex situ” method. The polymer matrix composite with AgNPs was prepared in two ways: as a composite film and nanofibers (nonwoven textile). The anti-biofilm activity of AgNPs and the ability of AgNPs to transfer toxic properties into the polymer matrix were proved.
An Imidazolium-Based Ionic Liquid as a Model to Study Plasticization Effects on Cationic Polymethacrylate Films
Authors: Marimuthu Thashree , Sidat Zainul , Kumar Pradeep , Choonara Yahya E.
Published: March 2023

Ionic liquids (ILs) have been touted as effective and environmentally friendly agents, which has driven their application in the biomedical field. The study compares the effectiveness of an IL agent, 1-hexyl-3-methyl imidazolium chloride ([HMIM]Cl), to current industry standards for plasticizing a methacrylate polymer. Industrial standards glycerol, dioctyl phthalate (DOP) and the combination of [HMIM]Cl with a standard plasticizer was also evaluated. Plasticized samples were evaluated for stress–strain, long-term degradation, thermophysical characterizations, and molecular vibrational changes within the structure, and molecular mechanics simulations were performed. Physico-mechanical studies showed that [HMIM]Cl was a comparatively good plasticizer than current standards reaching effectiveness at 20–30% w/w, whereas plasticizing of standards such as glycerol was still inferior to [HMIM]Cl even at concentrations up to 50% w/w. Degradation studies show HMIM-polymer combinations remained plasticized for longer than other test samples, >14 days, compared to glycerol <5 days, while remaining more pliable. The combination of [HMIM]Cl-DOP was effective at concentrations >30% w/w, demonstrating remarkable plasticizing capability and long-term stability. ILs used as singular agents or in tandem with other standards provided equivalent or better plasticizing activity than the comparative free standards.
PET/Graphene Nanocomposite Fibers Obtained by Dry-Jet Wet-Spinning for Conductive Textiles
Authors: León-Boigues Laia , Flores Araceli , Gómez-Fatou Marian A. , Vega Juan F. , Ellis Gary J. , Salavagione Horacio J.
Published: March 2023

The combination of polyethylene terephthalate (PET), one of the most used polymers in the textile industry, with graphene, one of the most outstanding conductive materials in recent years, represents a promising strategy for the preparation of conductive textiles. This study focuses on the preparation of mechanically stable and conductive polymer textiles and describes the preparation of PET/graphene fibers by the dry-jet wet-spinning method from nanocomposite solutions in trifluoroacetic acid. Nanoindentation results show that the addition of a small amount of graphene (2 wt.%) to the glassy PET fibers produces a significant modulus and hardness enhancement (≈10%) that can be partly attributed to the intrinsic mechanical properties of graphene but also to the promotion of crystallinity. Higher graphene loadings up to 5 wt.% are found to produce additional mechanical improvements up to ≈20% that can be merely attributed to the superior properties of the filler. Moreover, the nanocomposite fibers display an electrical conductivity percolation threshold over 2 wt.% approaching ≈0.2 S/cm for the largest graphene loading. Finally, bending tests on the nanocomposite fibers show that the good electrical conductivity can be preserved under cyclic mechanical loading.
Effects of the Curing Regime, Acid Exposure, Alkaline Activator Dosage, and Precursor Content on the Strength Development of Mortar with Alkali-Activated Slag and Fly Ash Binder: A Critical Review
Authors: Mohamed Osama A.
Published: March 2023

Reductions of green gas emissions and the reuse/recycling of industrial byproducts are important for the mitigation of the environmental impact of the construction industry. The replacement of ordinary Portland cement (OPC) is a concrete binder with industrial byproducts that possess sufficient cementitious and pozzolanic properties, such as ground granulated blast furnace slag (GBS) and fly ash. This critical review analyzes the effect of some of the most critical parameters on the development of the compressive strength of concrete or mortar that consists of combinations of alkali-activated GBS and fly ash as binders. The review includes the effects of the curing environment, the proportions of GBS and fly ash in the binder, and the concentration of the alkaline activator on strength development. The article also reviews the effect of exposure as well as the age of samples at the time of exposure to acidic media on the development of concrete strength. The effect of acidic media on mechanical properties was found to depend not only on the type of acid but also on the alkaline activator solution, proportions of GBS and fly ash in the binder, and the age of the sample at the time of exposure, among other factors. As a focused review, the article pinpoints important findings such as the change in compressive strength over time when mortar/concrete is cured in an environment that permits the loss of moisture versus curing in a system that retains the alkaline solution and keeps reactants available for hydration and the development of geopolymerization products. The relative contents of slag and fly ash in blended activators have a significant impact on strength development. Research methods used include a critical review of the literature, a comparison of reported research findings, and identifying reasons for agreement or disagreement of findings.
Recent Advances in Centrifugal Spinning and Their Applications in Tissue Engineering
Authors: Marjuban Shaik Merkatur Hakim , Rahman Musfira , Duza Syeda Sharmin , Ahmed Mohammad Boshir , Patel Dinesh K. , Rahman Md Saifur , Lozano Karen
Published: March 2023

Over the last decade, researchers have investigated the potential of nano and microfiber scaffolds to promote wound healing, tissue regeneration, and skin protection. The centrifugal spinning technique is favored over others due to its relatively straightforward mechanism for producing large quantities of fiber. Many polymeric materials have yet to be investigated in search of those with multifunctional properties that would make them attractive in tissue applications. This literature presents the fundamental process of fiber generation, and the effects of fabrication parameters (machine, solution) on the morphologies such as fiber diameter, distribution, alignment, porous features, and mechanical properties. Additionally, a brief discussion is presented on the underlying physics of beaded morphology and continuous fiber formation. Consequently, the study provides an overview of the current advancements in centrifugally spun polymeric fiber-based materials and their morphological features, performance, and characteristics for tissue engineering applications.
Lignin-Based Admixtures: A Scientometric Analysis and Qualitative Discussion Applied to Cement-Based Composites
Authors: Carvalho Victor Rezende , Costa Laís Cristina Barbosa , Baeta Bruno Eduardo Lobo , Peixoto Ricardo André Fiorotti
Published: March 2023

The development of lignin-based admixtures (LBAs) for cement-based composites is an alternative to valorizing residual lignins generated in biorefineries and pulp and paper mills. Consequently, LBAs have become an emerging research domain in the past decade. This study examined the bibliographic data on LBAs through a scientometric analysis and in-depth qualitative discussion. For this purpose, 161 articles were selected for the scientometric approach. After analyzing the articles’ abstracts, 37 papers on developing new LBAs were selected and critically reviewed. Significant publication sources, frequent keywords, influential scholars, and contributing countries in LBAs research were identified during the science mapping. The LBAs developed so far were classified as plasticizers, superplasticizers, set retarders, grinding aids, and air-entraining admixtures. The qualitative discussion revealed that most studies have focused on developing LBAs using Kraft lignins from pulp and paper mills. Thus, residual lignins from biorefineries need more attention since their valorization is a relevant strategy for emerging economies with high biomass availability. Most studies focused on production processes, chemical characterizations, and primary fresh-state analyses of LBA-containing cement-based composites. However, to better assess the feasibility of using different LBAs and encompass the multidisciplinarity of this subject, it is mandatory that future studies also evaluate hardened-sate properties. This holistic review offers a helpful reference point to early-stage researchers, industry professionals, and funding authorities on the research progress in LBAs. It also contributes to understanding the role of lignin in sustainable construction.