bluuebunny/crossref_metadata_2025 huggingface dataset:
Nonpharmacological Interventions for Sleep Promotion on Preterm Infants in Neonatal Intensive Care Unit: A Systematic Review
Authors: Liao Jin‐Hua , Hu Rong‐Fang , Su Li‐Jing , Wang Shuo , Xu Qin , Qian Xiao‐Fang , He Hong‐Gu
Published: August 2018

Background

Nonpharmacological interventions are often used to promote sleep among preterm infants in the neonatal intensive care unit (NICU). However, there is a lack of synthesis in the evidence of their effectiveness.

Aim

To synthesize the evidence on the effectiveness of nonpharmacological interventions on NICU preterm infants’ sleep during hospital stay.

Methods

Seven databases were searched, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Wan‐fang database, China National Knowledge Infrastructure, China Biological Medicine Database, and VIP Journal Integration Platform from their inceptions to August 2017. Randomized controlled trials examining the effects of nonpharmacological interventions on preterm infants’ sleep were included.

Results

This review included 36 studies. Nonpharmacological interventions included the Newborn Individualized Developmental Care and Assessment Program (NIDCAP), music, non‐nutritive sucking, touch, cycled light, cobedding, rocking, oral sucrose, remolding mattresses, and family nurturing. The meta‐analysis results showed that 1. the NIDCAP had no significant effect on total sleep time efficiency (TST%; p = .34); 2. mattress interventions had significant effects on TST% (p < .001); and active sleep efficiency (AS%; p = .006) but no significant effect on quiet sleep efficiency (QS%; p = .75); 3. cycled light increased TST (p = .02); and 4. cobedding had no significant effects on QS% and AS% (p = .63 and p = .88, respectively).

Linking Evidence to Action

Remolding mattresses and cycled light had significant effects on sleep promotion in preterm infants, but the quality of the evidence was very low. Further high‐quality studies are needed to strengthen this evidence.
Cellulosic-Biowaste Composites and Their Stress Determination Using Digital Image Correlation
Authors: Ro Yoonhyuk , Hunt John F. , Rowlands Robert E.
Published: August 2018

In addition to processing a troubling agricultural by-product and reducing demands on our landfills, prepared agro-waste composites are suitable for a variety of practical applications. However, enhancing value-added options for these agricultural by-products can necessitate ability to assess their mechanical integrity. This paper accordingly describes the preparation of a cellulosic-manure composite and demonstrates ability to determine stresses in a perforated structure of the material from measured displacement data. Processing digital image correlation (DIC) recorded displacement information with an Airy stress function gives reliable results full-field as well as at the edge of geometric discontinuities without having to differentiate the recorded data. Required constitutive properties are evaluated in situ and results are substantiated independently.
Using Liquid Metal in an Electromechanical Motor With Breathing Mode Motion
Authors: Farzbod Farhad , Naghdi Masoud , Goggans Paul M.
Published: August 2018

Electromechanical actuators exploit the Lorentz force law to convert electrical energy into rotational or linear mechanical energy. In these electromagnetically induced motions, the electrical current flows through wires that are rigid, and consequently, the types of motion generated are limited. Recent advances in preparing liquid metal alloys permit wires that are flexible. Such wires have been used to fabricate various forms of flexible connections, but very little has been done to use liquid metal as an actuator. In this paper, we propose and have tested a new type of motor using liquid metal conductors in which radial (or breathing) modes are activated.
Influence of Blade Loading Profile on Wake Dynamics in High-Pressure Turbine Cascades
Authors: Luymes Benjamin T. , An Qiang , Steinberg Adam M. , Zhang Xuefeng , Vandeputte Thomas
Published: August 2018

The influences of blade loading profile on wake convection and wake/wake interaction were studied in two different blade designs for high-pressure (HP) turbines (front-loaded (FL) and aft-loaded (AL)), installed in linear cascades. A high-speed moving bar (HSMB) apparatus replicated wake shedding, and a closed loop wind tunnel produced engine-relevant Mach numbers (Ma = 0.7) and Reynolds numbers (Re = 3 × 105). The FL blades had approximately 10% greater total pressure loss when operated with unsteady wake passage. Phase conditioned particle image velocimetry (PIV) measurements were made in the aft portion of the blade channel and downstream of the blade trailing edge. The turbulence kinetic energy (TKE) in the wake was approximately 30% higher for the FL blades when the wake entered the measurement field-of-view. The pressure field in the upstream region of the FL blade design is believed to induce high magnitude strain rates—leading to increased TKE production—and more aggressively turn and dilate the unmixed wake—leading to increased mixing related losses. The higher TKE for the FL blades largely dissipated, being approximately equal to the AL wake by the time the wake reached the end of the blade passage. The interaction of the convected wake with the wake from the blade trailing edge caused periodic vortex shedding at the second harmonic of the convected wake frequency. This interaction also modulated the strength of the trailing edge wake. However, little difference was found in the modulation amplitudes between different cases due to similar strengths of the convected wakes in this region. The higher wake TKE in the upstream portion of the blade channel for the FL blades, therefore, is expected to be the cause of the higher total pressure loss.
Poststall Behavior of a Multistage High Speed Compressor at Off-Design Conditions
Authors: Zhao Fanzhou , Dodds John , Vahdati Mehdi
Published: August 2018

Stall followed by surge in a high speed compressor can lead to violent disruption of flow, damage to the blade structures and, eventually, engine shutdown. Knowledge of unsteady blade loading during such events is crucial in determining the aeroelastic stability of blade structures; experimental test of such events is, however, significantly limited by the potential risk and cost associated. Numerical modeling, such as unsteady computational fluid dynamics (CFD) simulations, can provide a more informative understanding of the flow field and blade forcing during poststall events; however, very limited publications, particularly concerning multistage high speed compressors, can be found. The aim of this paper is to demonstrate the possibility of using CFD for modeling full-span rotating stall and surge in a multistage high speed compressor, and, where possible, validate the results against experimental measurements. The paper presents an investigation into the onset and transient behavior of rotating stall and surge in an eight-stage high speed axial compressor at off-design conditions, based on 3D Reynolds-averaged Navier–Stokes (URANS) computations, with the ultimate future goal being aeroelastic modeling of blade forcing and response during such events. By assembling the compressor with a small and a large exit plenum volume, respectively, a full-span rotating stall and a deep surge were modeled. Transient flow solutions obtained from numerical simulations showed trends matching with experimental measurements. Some insights are gained as to the onset, propagation, and merging of stall cells during the development of compressor stall and surge. It is shown that surge is initiated as a result of an increase in the size of the rotating stall disturbance, which grows circumferentially to occupy the full circumference resulting in an axisymmetric flow reversal.
How Is Physical Literacy Defined? A Contemporary Update
Authors: Shearer Cara , Goss Hannah R. , Edwards Lowri C. , Keegan Richard J. , Knowles Zoe R. , Boddy Lynne M. , Durden-Myers Elizabeth J. , Foweather Lawrence
Published: August 2018

Physical literacy continues to gain global momentum, yet the definition and underlying concept of physical literacy remain contested in both research and practice. This lack of clarity has the potential to undermine the operationalization of physical literacy. This paper considers the various definitions of physical literacy that are currently adopted internationally. Physical literacy experts identified seven leading groups that have established physical literacy initiatives. Although each group is unified in using the term physical literacy, there are contrasting definitions and interpretations of the concept. Common themes were identified, including the (a) influence of physical literacy philosophy, (b) core elements of physical literacy, (c) lifelong nature of physical literacy, and (d) the need to scientifically pursue a robust operationalization of the concept. We conclude by recommending that programs relating to physical literacy should provide a definition, a clear philosophical approach, and transparency with how their actions align with this approach.
Large-Scale Physical Education Interventions: Past, Present, and Future
Authors: Castelli Darla M. , Chen Ang
Published: August 2018

A large body of Catherine Ennis’s work is focused on physical education curriculum development. Her approach to curriculum development is unique in that it is completely based on research evidence. The curricula she developed have been field-tested and the completed curriculum is supported with solid research evidence to demonstrate its efficacy in student learning and teacher ease of use. The purpose of this article is to provide an overview and explore opportunities to continue large-scale physical education curriculum intervention studies. The authors first provide a brief review of previous intervention studies by summarizing the findings and discussing implications. They then discuss potential future intervention studies by presenting several topics that are being explored by researchers in current interventions. Finally, they focus on methodology issues involved in designing effective curriculum intervention studies with the idea of adaptive designs as variations of the randomized clinical trial design.
Safety of 5914 intravitreal ziv-aflibercept injections
Authors: Singh Sumit Randhir , Stewart Michael W , Chattannavar Goura , Ashraf Mohammed , Souka Ahmed , ElDardeery Mazen , Wadhwa Neeraj , Sarvaiya Chintan , Mansour Ahmad M , Marashi Ameen , Ramchandani Suresh , Braimah Imoro Zeba , Jabbarpoor Bonyadi Mohammad Hossein , Ramezani Alireza , Soheilian Masoud , de Oliveira Dias João Rafael , de Andrade Gabriel Costa , Maia André , Rodrigues Eduardo Büchele , Farah Michel Eid , Banker Alay , Chhablani Jay
Published: August 2018

Purpose

To analyse the pooled safety data of intravitreal ziv-aflibercept (IVZ) therapy for various retinal conditions.

Methods

This was a retrospective, observational study which included patients from 14 participating centres who received IVZ. The medical records of patients who received IVZ from March 2015 through October 2017 were evaluated. Patient demographics and ocular details were compiled. Ocular and systemic adverse events that occurred within 1 month of IVZ injections were recorded and defined as either procedure-related or drug-related.

Results

A total of 1704 eyes of 1562 patients received 5914 IVZ injections (mean±SD: 3.73±3.94) during a period of 2.5 years. The age of patients was 60.6±12.8 years (mean±SD) and included diverse chorioretinal pathologies. Both ocular (one case of endophthalmitis, three cases of intraocular inflammation, and one case each of conjunctival thinning/necrosis and scleral nodule) and systemic adverse events (two cases of myocardial infarction, one case of stroke and two deaths) were infrequent.

Conclusion

This constitutes the largest pooled safety report on IVZ use and includes patients from 14 centres distributed across the globe. It shows that IVZ has an acceptable ocular and systemic safety profile with incidences of adverse events similar to those of other vascular endothelial growth factor inhibitory drugs. The analysis supports the continued use of IVZ in various retinal disorders.
Cancer and suicidal ideation and behaviours: protocol for a systematic review and meta-analysis
Authors: Calati Raffaella , Fang Fang , Mostofsky Elizabeth , Shen Qing , Di Mattei Valentina Elisabetta , Garcia-Foncillas Jesus , Baca-Garcia Enrique , Cipriani Andrea , Courtet Philippe
Published: August 2018

Introduction

Prevalence of suicidal ideation (SI) and behaviours are higher among patients with cancer than general population. No systematic review/meta-analysis investigated this topic; therefore, our aim will be to assess the relationship between cancer and SI and behaviours.

Methods

We will search PubMed/MEDLINE, EMBASE, SCOPUS, Web of Science, PsycINFO and Cochrane Library databases from their inception until 30 June 2018. Case–control and cohort studies focused on the association between cancer (any type) and suicidal outcomes (suicide, suicide attempt and SI) will be included. Two team members will independently: (A) perform the selection of the included studies and data extraction, with the supervision of a third member in case of discrepancies and (B) assess each study with: (1) Newcastle-Ottawa Scale (NOS); (2) Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement; (3) Grading of Recommendations Assessment, Development and Evaluation (GRADE). We will conduct a random-effects meta-analysis. Individual and pooled ORs and associated 95% CIs will be calculated as well as between-study heterogeneity. We will examine the potential for publication bias. If possible, we will explore reasons for potential between-study heterogeneity.

Ethics and dissemination

This study does not require ethical approval. The study will be submitted to a peer-reviewed journal, will be publicly disseminated and will be the topic of research presentations.

PROSPERO registration number

CRD42017072482.
Combining online Community Reinforcement and Family Training (CRAFT) with a parent-training programme for parents with partners suffering from alcohol use disorder: study protocol for a randomised controlled trial
Authors: Lindner Philip , Siljeholm Ola , Johansson Magnus , Forster Martin , Andreasson Sven , Hammarberg Anders
Published: August 2018

Introduction

Partners and children of individuals with alcohol use disorder (AUD) present with impaired quality of life and mental health, yet seldom seek or participate in traditional supportive interventions. Engaging the parent/partner without AUD in treatment is a promising way of supporting behavioural change in both the child and the parent with AUD. Universal parent-training (PT) programmes are effective in increasing children’s well-being and decreasing problem behaviours, but have yet to be tailored for children with a parent with AUD. Community Reinforcement Approach And Family Training (CRAFT) programmes are conceptually similar, and aim to promote behavioural change in individuals with AUD by having a concerned significant other change environmental contingencies. There has been no study on whether these two interventions can be combined and tailored for partners of individuals with AUD with common children, and delivered as accessible, online self-help.

Methods and analysis

n=300 participants with a child showing mental health problems and partner (co-parent) with AUD, but who do not themselves present with AUD, will be recruited from the general public and randomised 1:1 to either a four-module, online combined PT and CRAFT programme or a psychoeducation-only comparison intervention. Primary outcome will be the child’s mental health. Additional outcomes will cover the partner’s drinking, the participants own mental health and drinking, the child’s social adjustment, treatment seeking in all three parties and parental self-efficacy. Measures will be collected preintervention, mid-intervention and postintervention, and three times during a 2-year follow-up period. Data will be analysed using mixed-effects modelling.

Ethics and dissemination

This study has been approved by the Stockholm Regional Ethical Review Board (2016/2179-31). The results will be presented at conferences and published as peer-reviewed publications.

Trial registration number

ISRCTN38702517; Pre-results.
Electronic patient-generated health data to facilitate prevention and health promotion: a scoping review protocol
Authors: Nittas Vasileios , Mütsch Margot , Ehrler Frederic , Puhan Milo Alan
Published: August 2018

Introduction

Rapidly expanding digital innovations transform the perception, reception and provision of health services. Simultaneously, health system challenges underline the need for patient-centred, empowering and citizen-engaging care, which facilitates a focus on prevention and health promotion. Through enhanced patient-engagement, patient-provider interactions and reduced information gaps, electronic patient-generated health data (PGHD) may facilitate both patient-centeredness and preventive scare. Despite that, comprehensive knowledge syntheses on their utilisation for prevention and health promotion purposes are lacking. The review described in this protocol aims to fill that gap.

Methods and analysis

Our methodology is guided by Arksey and O’ Malley’s methodological framework for scoping reviews, as well as its advanced version by Levac, Colquhoun and O’Brien. Seven electronic databases will be systematically searched using predefined keywords. Key electronic journals will be hand searched, while reference lists of included documents and grey literature sources will be screened thoroughly. Two independent reviewers will complete study selection and data extraction. One of the team’s senior research members will act as a third reviewer and make the final decision on disputed documents. We will include literature with a focus on electronic PGHD and linked to prevention and health promotion. Literature on prevention that is driven by existing discomfort or disability goes beyond the review’s scope and will be excluded. Analysis will be narrative and guided by Shapiroet al’s adapted framework on PGHD flow.

Ethics and dissemination

The scoping review described in this protocol aims to establish a baseline understanding of electronic PGHD generation, collection, communication, sharing, interpretation, utilisation, context and impact for preventive purposes. The chosen methodology is based on the use of publicly available information and does not require ethical approval. Review findings will be disseminated in digital health conferences and symposia. Results will be published and additionally shared with relevant local and national authorities.
Evaluation of capillary pathologies by nailfold capillaroscopy in patients with psoriasis vulgaris: study protocol for a prospective, controlled exploratory study
Authors: Fink Christine , Kilian Samuel , Bertlich Ines , Hoxha Elti , Bardehle Felicitas , Enk Alexander , Haenssle Holger A
Published: August 2018

Introduction

Psoriasis vulgaris was shown to be an independent factor increasing the risk of several comorbidities such as obesity, diabetes and dyslipidaemia with an increased risk of stroke and myocardial infarction. We hypothesise that early endothelial dysfunction, which plays a crucial role in the pathogenesis of atherosclerosis, may be detected by digital video nailfold capillaroscopy (DVNC) at the level of the dermal capillary microvasculature as a surrogate parameter. Nailfolds represent the only body site allowing for a non-invasive assessment of the capillary microvasculature at a horizontal plane. DVNC is a well-established diagnostic tool for in vivo assessment of the peripheral microcirculation by evaluating the morphology of dermal papillary capillaries. To date, reports on morphological changes of the non-lesional nailfold capillaries in patients with psoriasis vulgaris are scarce and the existing data are not conclusive.

Methods and analysis

This is a prospective, single-centre, non-randomised, controlled, exploratory study assessing the capillary patterns in 100 subjects affected by psoriasis vulgaris. Non-lesional nailfold capillaries will be imaged by means of DVNC (Optilia Digital Capillaroscopy System, Optilia Instruments AB, Sollentuna, Sweden) in 50 patients affected by psoriasis vulgaris and 50 healthy controls. Assessments will include a qualitative, descriptive analysis of the nailfold capillaries’ morphology, as well as a quantitative investigation (frequency, extent) of changes in capillary patterns. Moreover, patients’ characteristics associated with the manifestation of nailfold capillaries’ pathologies including well-known cardiovascular risk markers will be studied.

Ethics and dissemination

Ethical approval was provided by the ethic committee of the medical faculty of the University of Heidelberg (Ethics approval number S-447/2017). The design and the final results of the study will be published and made available to the public.

Trial registration number

DRKS00012856.
Laparoscopic or open distal gastrectomy after neoadjuvant chemotherapy for advanced gastric cancer: study protocol for a randomised phase II trial
Authors: Li Ziyu , Shan Fei , Ying Xiangji , Zhang Lianhai , Ren Hui , Li Shuangxi , Jia Yongning , Miao Rulin , Xue Kan , Li Zhemin , Wang Yinkui , Yan Chao , Zhang Yan , Pang Fei , Ji Jiafu
Published: August 2018

Introduction

Current guidelines recommend open gastrectomy with D2 lymph node dissection and adjuvant chemotherapy as the standard treatment for advanced gastric cancer. However, the prognosis is not satisfactory. Perioperative chemotherapy has been proposed to improve survival. Although still in debate, the efficacy of laparoscopic distal gastrectomy (LDG) in patients with advanced gastric cancer has been demonstrated in a few trials. Therefore, LDG after neoadjuvant chemotherapy can be a candidate for future standard treatment on advanced distal gastric cancer. We propose a randomised phase II trial to compare LDG and open distal gastrectomy (ODG) after neoadjuvant chemotherapy for advanced gastric cancer.

Methods and analysis

To test the efficacy and safety, a randomised, open-label, single-centre, phase II trial was designed to evaluate the non-inferiority of LDG compared with ODG after neoadjuvant chemotherapy, with 3-year recurrence-free survival as the primary endpoint. The chosen critical value of a non-inferiority margin was an increase of <8%. The study started in 2015 and enrolled 96 patients according to a prior sample size calculation. Intention-to-treat and per-protocol approach will be used for efficacy analysis, and as-treated analysis will be applied for safety analysis. The survival curves will be constructed as time-to-event plots using the Kaplan-Meier method and compared using log-rank tests and Cox proportional hazards model. All statistical analyses will be conducted in standard statistical software with a significance level of 0.05.

Ethics and dissemination

This study was approved by the Peking University Cancer Hospital Ethics Committee. The results will be submitted for publication in peer-reviewed journals.

Trial registration number

NCT02404753; Pre-results.
Cost-effectiveness of interventions for perinatal anxiety and/or depression: a systematic review
Authors: Camacho Elizabeth M , Shields Gemma E
Published: August 2018

Objectives

Anxiety and/or depression during pregnancy or year after childbirth is the most common complication of childbearing. Economic evaluations of interventions for the prevention or treatment of perinatal anxiety and/or depression (PAD) were systematically reviewed with the aim of guiding researchers and commissioners of perinatal mental health services towards potentially cost-effective strategies.

Methods

Electronic searches were conducted on the MEDLINE, PsycINFO and NHS Economic Evaluation and Health Technology Assessment databases in September 2017 to identify relevant economic evaluations published since January 2000. Two stages of screening were used with prespecified inclusion/exclusion criteria. A data extraction form was designed prior to the literature search to capture key data. A published checklist was used to assess the quality of publications identified.

Results

Of the 168 non-duplicate citations identified, 8 studies met the inclusion criteria for the review; all but one focussing solely on postnatal depression in mothers. Interventions included prevention (3/8), treatment (3/8) or identification plus treatment (2/8). Two interventions were likely to be cost-effective, both incorporated identification plus treatment. Where the cost per quality-adjusted life year (QALY) gained was reported, interventions ranged from being dominant (cheaper and more effective than usual care) to costing £39 875/QALY.

Conclusions

Uncertainty and heterogeneity across studies in terms of setting and design make it difficult to make direct comparisons or draw strong conclusions. However, the two interventions incorporating identification plus treatment of perinatal depression were both likely to be cost-effective. Many gaps were identified in the economic evidence, such as the cost-effectiveness of interventions for perinatal anxiety, antenatal depression or interventions for fathers.

PROSPERO registration number

CRD42016051133.
Manual ventilation to prevent hypoxaemia during endotracheal intubation of critically ill adults: protocol and statistical analysis plan for a multicentre randomised trial
Authors: Casey Jonathan D , Janz David R , Russell Derek W , Vonderhaar Derek J , Joffe Aaron M , Dischert Kevin M , Brown Ryan M , Lester Michael G , Zouk Aline N , Gulati Swati , Stigler William S , Rice Todd W , Semler Matthew W
Published: August 2018

Introduction

Hypoxaemia is the most common complication during endotracheal intubation of critically ill adults, and it increases the risk of cardiac arrest and death. Manual ventilation between induction and intubation has been hypothesised to decrease the incidence of hypoxaemia, but efficacy and safety data are lacking.

Methods and analysis

The Preventing Hypoxemia with Manual Ventilation during Endotracheal Intubation trial is a prospective, multicentre, non-blinded randomised clinical trial being conducted in seven intensive care units in the USA. A total of 400 critically ill adults undergoing endotracheal intubation will be randomised 1:1 to receive prophylactic manual ventilation between induction and endotracheal intubation using a bag-valve-mask device or no prophylactic ventilation. The primary outcome is the lowest arterial oxygen saturation between induction and 2 min after successful endotracheal intubation, which will be analysed as an unadjusted, intention-to-treat comparison of patients randomised to prophylactic ventilation versus patients randomised to no prophylactic ventilation. The secondary outcome is the incidence of severe hypoxaemia, defined as any arterial oxygen saturation of less than 80% between induction and 2 min after endotracheal intubation. Enrolment began on 2 February 2017 and is expected to be complete in May 2018.

Ethics and dissemination

The trial was approved by the institutional review boards or designees of all participating centres. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences.

Trial registration number

NCT03026322; Pre-results.
Pain education for patients with non-specific low back pain in Nepal: protocol of a feasibility randomised clinical trial (PEN-LBP Trial)
Authors: Sharma Saurab , Jensen Mark P , Moseley G Lorimer , Abbott J Haxby
Published: August 2018

Introduction

Low back pain (LBP) is the leading cause of years lived with disability in Nepal and elsewhere. Management of LBP that is evidence-based, easily accessible, cost-effective and culturally appropriate is desirable. The primary aim of this feasibility study is to determine if it is feasible to conduct a full randomised clinical trial evaluating the effectiveness of pain education as an intervention for individuals with LBP in Nepal, relative to guideline-based physiotherapy treatment. The findings of the study will inform the planning of a full clinical trial and if any modifications are required to the protocol before undertaking a full trial.

Methods/analysis

This protocol describes an assessor-blinded feasibility clinical trial investigating feasibility of the pain education intervention in patients with non-specific LBP in a physiotherapy hospital in Kathmandu, Nepal. Forty patients with LBP will be randomly allocated to either pain education or guideline-based physiotherapy treatment (control). Outcomes will be assessed at baseline and at a 1 week post-treatment. The primary outcomes are related to feasibility, including: (1) participant willingness to participate in a randomised clinical trial, (2) feasibility of assessor blinding, (3) eligibility and recruitment rates, (4) acceptability of screening procedures and random allocation, (5) possible contamination between the groups, (6) intervention credibility, (7) intervention adherence, (8) treatment satisfaction and (9) difficulty in understanding the interventions being provided.

Ethics/dissemination

The protocol was approved by Nepal Health Research Council (NHRC; registration number: 422/2017) and University of Otago Human Ethics Committee for Health (registration number: H17/157). The results of the study will be presented at national and international conferences and published in a peer-reviewed journal.

Trial registration number

NCT03387228; Pre-results.
Meanings of ‘centredness’ in long-term care facilities: a scoping review protocol
Authors: Thompson Genevieve , Shindruk Chloe Lyn , Adekoya Adebusola Abiodun , Demczuk Lisa , McClement Susan
Published: August 2018

Introduction

There is a growing demand for long-term care services for older adults that embrace a model of care centred on individual recipients of care. In long-term care, models of person, resident and relationship-centred care have been developed and implemented to promote independence, decision making and choices of residents. Although the concepts of centredness have been readily adopted in these environments, what constitutes centredness is often vague and lacks conceptual clarity and definition. The research questions guiding this scoping review are: (1) What are the defining attributes, conceptual boundaries and theoretical underpinnings of each centredness term in long-term care? (2) For what purposes have centredness directed models of care been used in this context? (3) What types of study designs have been used to examine centredness in this context? (4) What outcomes related to centredness have been reported or evaluated and how were they measured in long-term care?

Methods and analysis

This review uses the methodological framework for conducting a scoping review by Arksey and O’Malley. The search strategy will be applied to nine bibliographic and citation databases, Google Scholar and the grey literature. Study selection will occur in a two-step process. First, the titles and abstracts of all search results will be screened by individual reviewers. Second, a full-text review will be conducted by a pair of reviewers. To be included articles must (1) define centredness in the context of long-term care; (2) describe the defining features of centredness; (3) explore the theoretical underpinnings of centredness; (4) outline outcomes of centredness or (5) use outcome measures related to centredness. Data will be extracted from included studies and analysed using thematic analysis as described by Braun and Clark.

Ethics and dissemination

Research ethics approval is not required for this scoping review. Dissemination strategies will follow a targeted and tailored approach based on study findings.
Protocol paper for the ‘Harnessing resources from the internet to maximise outcomes from GP consultations (HaRI)’ study: a mixed qualitative methods study
Authors: Seguin Maureen , Hall Laura , Atherton Helen , Barnes Rebecca , Leydon Geraldine , Murray Elizabeth , Pope Catherine , Ziebland Sue , Stevenson Fiona A
Published: August 2018

Introduction

Many patients now turn to the internet as a resource for healthcare information and advice. However, patients’ use of the internet to manage their health has been positioned as a potential source of strain on the doctor–patient relationship in primary care. The current evidence about what happens when internet-derived health information is introduced during consultations has relied on qualitative data derived from interview or questionnaire studies. The ‘Harnessing resources from the internet to maximise outcomes from GP consultations (HaRI)’ study combines questionnaire, interview and video-recorded consultation data to address this issue more fully.

Methods and analysis

Three data collection methods are employed: preconsultation patient questionnaires, video-recorded consultations between general practitioners (GP) and patients, and semistructured interviews with GPs and patients. We seek to recruit 10 GPs practising in Southeast England. We aim to collect up to 30 patient questionnaires and video-recorded consultations per GP, yielding up to 300. Up to 30 patients (approximately three per participating GP) will be selected for interviews sampled for a wide range of sociodemographic characteristics, and a variety of ways the use of, or information from, the internet was present or absent during their consultation. We will interview all 10 participating GPs about their views of online health information, reflecting on their own usage of online information during consultations and their patients’ references to online health information. Descriptive, conversation and thematic analysis will be used respectively for the patient questionnaires, video-recorded consultations and interviews.

Ethics and dissemination

Ethical approval has been granted by the London–Camden & Kings Cross Research Ethics Committee. Alongside journal publications, dissemination activities include the creation of a toolkit to be shared with patients and doctors, to guide discussions of material from the internet in consultations.
Increasing engagement in advance care planning using a behaviour change model: study protocol for the STAMP randomised controlled trials
Authors: Fried Terri R , Redding Colleen A , Martino Steven , Paiva Andrea , Iannone Lynne , Zenoni Maria , Blakley Laura A , Rossi Joseph S , O’Leary John
Published: August 2018

Introduction

Advance care planning (ACP) is a key component of high-quality end-of-life care but is underused. Interventions based on models of behaviour change may fill an important gap in available programmes to increase ACP engagement. Such interventions are designed for broad outreach and flexibility in delivery. The purpose of the Sharing and Talking about My Preferences study is to examine the efficacy of three behaviour change approaches to increasing ACP engagement through two related randomised controlled trials being conducted in different settings (Veterans Affairs (VA) medical centre and community).

Methods and analysis

Eligible participants are 55 years or older. Participants in the community are being recruited in person in primary care and specialty outpatient practices and senior living sites, and participants in the VA are recruited by telephone. In the community, randomisation is at the level of the practice or site, with all persons at a given practice/site receiving either computer-tailored feedback with a behaviour stage-matched brochure (computer-tailored intervention (CTI)) or usual care. At the VA, randomisation is at the level of the participant and is stratified by the number of ACP behaviours completed at baseline. Participants are randomised to one of four groups: CTI, motivational interviewing, motivational enhancement therapy or usual care. The primary outcome is completion of four key ACP behaviours: identification of a surrogate decision maker, communication about goals, completing advance directives and ensuring documents are in the medical record. Analysis will be conducted using mixed effects models, taking into account the clustered randomisation for the community study.

Ethics and randomisation

The studies have been approved by the appropriate Institutional Review Boards and are being overseen by a Safety Monitoring Committee. The results of these studies will be disseminated to academic audiences and leadership in in the community and VA sites.

Trial registration numbers

NCT03137459andNCT03103828.
CD147 expression is associated with poor overall survival in chemotherapy treated triple-negative breast cancer
Authors: Liu Ming , Tsang Julia Y S , Lee Michelle , Ni Yun-Bi , Chan Siu-Ki , Cheung Sai-Yin , Hu Jintao , Hu Hong , Tse Gary M K
Published: August 2018

Aims

In breast cancer models, the functional roles of CD147 in proliferation, invasion and treatment resistance have been widely reported. However, there are only a few studies examining the clinicopathological correlation and prognostic relevance of CD147 in breast cancer, especially in relation to breast cancer molecular subtypes.

Methods

In this study, we analysed CD147 expression in a large cohort of breast cancers, correlating with clinicopathological features and the expression of a comprehensive panel of biomarkers in triple-negative breast cancer (TNBC) and non-TNBC subsets. Its relationship with patients’ survival was also analysed.

Results

CD147 was expressed in 11.9%(140/1174) of all cases and in 23.8% (40/168) of TNBC. The expression was associated with tumour histological subtypes (p=0.01) and most commonly seen in carcinoma with medullary features (26.0%). CD147 expression correlated with high tumour grade, presence of necrosis and basal-like breast cancer (BLBC) subtype, high Ki67 and expression of some other basal markers and stem-like markers. CD147 expression was also associated with poor overall survival in chemotherapy treated patients with TNBC.

Conclusions

CD147 is a putative marker in identifying TNBC or BLBC, and may be useful as a prognosis indicator for patients with TNBC or BLBC post chemotherapy.
Revisiting the Privacy Paradox on Social Media With an Extended Privacy Calculus Model: The Effect of Privacy Concerns, Privacy Self-Efficacy, and Social Capital on Privacy Management
Authors: Chen Hsuan-Ting
Published: August 2018

This study builds on the privacy calculus model to revisit the privacy paradox on social media. A two-wave panel data set from Hong Kong and a cross-sectional data set from the United States are used. This study extends the model by incorporating privacy self-efficacy as another privacy-related factor in addition to privacy concerns (i.e., costs) and examines how these factors interact with social capital (i.e., the expected benefit) in influencing different privacy management strategies, including limiting profile visibility, self-disclosure, and friending. This study proposed and found a two-step privacy management strategy in which privacy concerns and privacy self-efficacy prompt users to limit their profile visibility, which in turn enhances their self-disclosing and friending behaviors in both Hong Kong and the United States. Results from the moderated mediation analyses further demonstrate that social capital strengthens the positive–direct effect of privacy self-efficacy on self-disclosure in both places, and it can mitigate the direct effect of privacy concerns on restricting self-disclosure in Hong Kong (the conditional direct effects). Social capital also enhances the indirect effect of privacy self-efficacy on both self-disclosure and friending through limiting profile visibility in Hong Kong (the conditional indirect effects). Implications of the findings are discussed.
Commentary on Jonathan Raskin’s “What Might an Alternative to the DSM Suitable for Psychotherapists Look Like?”
Authors: Cooper Rachel
Published: August 2018

Many mental health practitioners find it necessary to use the Diagnostic and Statistical Manual of Mental Disorders ( DSM) for insurance purposes but are unhappy with its basic assumptions. This raises the question—Would it be possible to devise a new classification system that (1) could be used for insurance purposes and (2) would be based on alternative principles? In the main, this commentary is pessimistic. Through considering the history of attempts to devise alternatives to the DSM, I will argue that it would be extremely difficult to develop an alternative to the DSM that could be used to fund psychotherapy via health care insurance in the United States.
Communication Apprehension About Death, Religious Group Affiliation, and Religiosity: Predictors of Organ and Body Donation Decisions
Authors: Carmack Heather J. , DeGroot Jocelyn M.
Published: August 2018

Communication willingness has previously been identified as an important communication factor in influencing individuals’ decisions to become an organ donor. Missing from this conversation is the role of communication apprehension about death and its impact on donation decisions. The purpose of this study was to examine the relationships between communication apprehension about death, religiosity, religious affiliation, and donation decisions. Three hundred and thirty-three individuals participated in an online survey. Findings suggest that communication apprehension about death, especially communication avoidance about death, negatively impact donation decisions. In addition, religiosity and affiliation with a specific religion also negatively impact donation decisions. These variables were also predictors of organ and body donation. The findings show a need for more research on what prevents conversations about donation. In addition, the stark difference between organ donation likelihood and body donation likelihood underscores the need for communication scholars to examine communication about body donation.
Testing the Test: Expanding the Dialogue on Technical Writing Assessment in the Academy and Workplace
Authors: Tanner Lindsay , Balzotti Jon
Published: August 2018

The small amount of work on workplace writing assessment has focused almost entirely on student readiness for professional writing or included case studies of employer expectations for new writers. While these studies provide insight into current pedagogies for technical writing and writing instruction in general, the main conclusion to be drawn from them is the unsatisfactory number of recent graduates who display workplace readiness. In this article, we explore writing assessment research in both the academy and the workplace and attempt to identify ways in which the academy’s assessment practices lead, lag behind, or simply differ from writing assessment in the workplace. This comparison will serve to identify not only where the academy might improve pedagogy in its curriculum for technical communication in order to best prepare students for workplace writing but also where the workplace might learn from the academy to improve its own hiring and training procedures for technical writers. In this case study, we used Neff’s approach to grounded theory to categorize rater feedback according to a ranking system and then used statistical analysis to compare writer performance. We found that the direct test method yields the most predictive results when raters combine tacit knowledge with a clearly defined rubric. We hope that the methods used in this study can be replicated in future studies to yield further results when exploring workplace genres and what they might teach us about our own pedagogical practice.
Patterns of the Mainstream Sound Change in a Liminal Region: Low Back Merger in Washington DC
Authors: Lee Sinae
Published: August 2018

This study investigates the low back vowel merger (lot-thought merger) of African American and European American speakers in Washington DC. The study aims to follow up with the previous investigation by Labov et al. (2006) on low back merger in DC, and investigate whether African American speakers in DC are participating in the merger, one of the majority-led sound changes. The study also examines the difference in low back vowel production between African Americans from a particular quadrant of the city, namely, Southeast (SE), and those from elsewhere in DC. Data are taken from forty sociolinguistic interviews with natives of DC. The vowels were analyzed acoustically, taking F1 and F2 measurements at three different points of a vowel. Both the F1 and the F2 dimensions of the low back vowels and the degree of overlap were examined. The degree of overlap was measured by calculating the Pillai score for each speaker, with duration and following environment taken into account. Results indicate that DC is conservatively participating in the merger, with European American speakers exhibiting higher degrees of overlap than African American speakers. An age effect is also observed, but only among African American speakers who are not from SE. The study further argues that the participation in the mainstream sound change by some African Americans can also be analyzed as convergence to the local white norm, and that this convergence is more likely to be carried out by African American speakers who are not from SE, a section of the city in which the contact between African American speakers and European American speakers is minimal.
Advancing Integrated Care through Psychiatric Workforce Development: A Systematic Review of Educational Interventions to Train Psychiatrists in Integrated Care
Authors: Sunderji Nadiya , Ion Allyson , Huynh Dan , Benassi Paul , Ghavam-Rassoul Abbas , Carvalhal Adriana
Published: August 2018

Objective:

Integrated or collaborative care is a well-evidenced and widely practiced approach to improve access to high-quality mental health care in primary care and other settings. Psychiatrists require preparation for this emerging type of practice, and such training is now mandatory for Canadian psychiatry residents. However, it is not known how best to mount such training, and in the absence of such knowledge, the quality of training across Canada has suffered. To guide integrated care education nationally, we conducted a systematic review of published and unpublished training programs.

Method:

We searched journal databases and web-based ‘grey’ literature and contacted all North American psychiatry residency programs known to provide integrated care training. We included educational interventions targeting practicing psychiatrists or psychiatry residents as learners. We critically appraised literature using the Medical Education Research Study Quality Instrument (MERSQI). We described the goals, content, and format of training, as well as outcomes categorized according to Kirkpatrick level of impact.

Results:

We included 9 published and 5 unpublished educational interventions. Studies were of low to moderate quality and reflected possible publication bias toward favourable outcomes. Programs commonly involved longitudinal clinical experiences for residents, mentoring networks for practicing physicians, or brief didactic experiences and were rarely oriented toward the most empirically supported models of integrated care. Implementation challenges were widespread.

Conclusions:

Similar to integrated care clinical interventions, integrated care training is important yet difficult to achieve. Educational initiatives could benefit from faculty development, quality improvement to synergistically improve care and training, and stronger evaluation.

Systematic review registration number:

PROSPERO 2014:CRD42014010295.