bluuebunny/crossref_metadata_2025 huggingface dataset:
ScRNA-Seq Reveals T Cell Immunity in COVID-19 Patients and Implications for Immunotherapy
Authors: ZHANG BAOJUN , Feng Zhao , Jiao Anjun , Zhang Hui
Published: January 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused
widespread transmission and been threatening health and lives due to
high infectivity, acute progression and lacking of effective treatment.
Both innate immunity and adaptive immunity are essential to defend
against viral infection, while T cells function as a bridge of both arms
and induce effective immune responses. Although traditional approaches
demonstrate general features of T cells in COVID-19 patients, there are
still a lot of unknown details to be characterized due to the complexity
of SARS-CoV-2 infection. Single-cell RNA sequencing (scRNA-seq)
technology is able to powerfully characterize gene expression at
single-cell level and new subsets at district differentiation stage or
with specific function. Here we have revealed the heterogeneity of the
host T cells, including CD4 T cells, CD8
T cells, regulatory T (Treg) cells, natural killer T
(NKT) cells, gamma-delta T (γδT) cells and mucosal-associated invariant
T (MAIT) cells in COVID-19 patients with different clinical
manifestations. T cell based therapeutic approaches, including enhancing
virus specific T cell responses, reverting T-cell exhaustion and
alleviating inflammation, are also discussed. This review provides
insights into clinical treatment and vaccine design for SARS-CoV-2
infection.
The Role of Executive Function and Temperament in the Emergence of Social Problem Solving Abilities During Preschool
Authors: Caporaso Jessica , Marcovitch Stuart
Published: January 2024

The current study examined the longitudinal association between
executive function (EF) and social problem solving abilities (SPS) and
the temperament factors that could influence this association. Two
accounts for the EF-SPS association were proposed; EF could either
support the emergence of an SPS concept over time (emergence account),
or it is only required for in-the-moment support during peer conflict
(expression account). To test these accounts, 4-to 5-year-old
participants completed a peer conflict task and EF tasks at the
beginning (T1) and end (T2) of the preschool year. Parents completed a
temperament questionnaire at T1. Results revealed that T1 EF predicted
T2 SPS abilities, but only for participants high in temperamental
surgency. The results provide support for the emergence account for a
specific group of children, further challenging the notion that EF is
required for all children to behave in a competent manner when faced
with peer provocation.
An analysis of the statin use frequency in COVID-19 patients before admission and its associations with disease severity and recovery rate
Authors: Azimi Ghasem , Amirizadeh Mehran , Kharazmkia Ali , amraie Mohsen Amiri , Birjandi Mehdi
Published: January 2024

Background: The most typical signs of Covid-19 (Corona), an acute
respiratory illness, include fever, coughing, exhaustion, shortness of
breath, sputum, and loss of smell. Due to their anti-inflammatory and
anti-thrombotic properties, statins have the potential to be useful in
treating Covid-19 patients’ endothelial dysfunction and uncontrolled
inflammation. This study’s goal was to determine the association between
statin use and the severity of the disease and rate of recovery in
COVID-19 hospitalized patients. Materials and Methods: In this
cross-sectional descriptive study, 400 cases were randomly selected from
patients admitted with Covid-19. The following factors were measured
using the available information in these patient records. Furthermore,
for data analysis, independent samples t-test or Mann-Whitney U test was
used. Results: In this study, which was performed on 400 patients with
Covid-19, the mean age of patients was 62.81 ± 11.78 years. Of the
patients studied, 225 (56.2%) were male and 175 (43.8%) were 175
female. 365 (91.2%) patients had an underlying disease and 372 (93%)
patients were discharged from all studied patients. Out of 87 patients
who had a history of statin use, 3 (4.3%) died and out of 313 patients
who had no history of statin use, 25 (8%) died. Conclusion: In this
study, men were more likely than women to be exposed to the coronavirus.
The highest rates of statin use and coronary heart disease were likewise
found in people aged 50 to 75. In patients who had previously taken
statins, recovery times, hospital stays, ICU stays, and the frequency of
clinical and laboratory measures were all quicker and closer to normal.
Moreover, patients with a history of statin use had a lower mortality
rate and a higher likelihood of recovery than other patients.
Global analysis of the influence of environmental variables to explain distributions and realized thermal niche boundaries of sea snakes
Authors: Patrón-Rivero Carlos , Osorio-Olvera Luis , Rojas-Soto Octavio R. , Chiappa-Carrara Xavier , Villalobos Fabricio , Reyes Kevin Lopez , Yañez-Arenas Carlos
Published: January 2024

Understanding the factors that affect species’ distributions is a
central topic of ecology and biogeography. However, the majority of
research about this topic has focused on species inhabiting terrestrial
environments. At broad scales, abiotic variables consistently serve as
the primary determinants of species’ distributions. In this study, we
investigate the explanatory power of different abiotic variables in
determining the distributional patterns of sea snakes on a global scale.
Additionally, as the boundaries of realized thermal niches have
significant implications for the ecology of the species and their
geographic distributions, we also evaluated the asymmetry of realized
thermal limits (i.e., differences in variances between upper and lower
limits of the realized thermal niche). We obtained global environmental
variables and occurrence data for each species across their entire known
geographic range. Using this data, we employed a correlative ecological
niche modeling procedure to analyze the influence of individual
variables in explaining species’ distributions. To estimate the realized
thermal limits of each species, we extracted the mean, minimum, and
maximum values of temperature at four depths (superficial, mean benthic,
minimum benthic, and maximum benthic) for each occurrence record of the
species. We then evaluated the asymmetry of the realized thermal niche
by measuring and comparing the variances of the upper and lower limits.
Both analyses (the importance of variables and realized thermal limit
asymmetry) were performed at three taxonomic levels (sea snakes as a
lineage of marine-adapted elapids [true sea snakes + sea kraits],
subfamily, and genus) and at two spatial resolutions. Overall, we found
that temperature, phosphate, nitrate, salinity and silicate
concentrations were the most influential factors in explaining the
spatial distribution patterns of sea snakes, regardless of the taxonomic
level or spatial resolution. Similarly, we observed that the realized
thermal limits were asymmetric with higher variance in the lower limits,
and that this asymmetry decreases as the taxonomic level and spatial
resolution increased. Finally, our results align with previous findings
regarding patterns of asymmetry in realized thermal limits and the
significant influence of abiotic variables in explaining the
distribution of marine species.
Interaction between long non-coding RNA and microRNA in lung diseases
Authors: Li Jiaqi , Liu Xiaoxiao , Shi Liangliang , Chen Guochang , Huang Shengyu , Liu Mingzhuo , Guo Guanghua
Published: January 2024

Non-coding RNAs are a group of RNAs that cannot synthesize proteins, but
are critical in the regulation of gene expression. A growing number of
studies discovered that miRNAs and lncRNAs, as the two major members of
the ncRNA family, play vital roles in regulating the physiological and
pathological processes of lung diseases, such as pneumonia, COPD
(chronic obstructive pulmonary disease), lung cancer, and asthma. These
interactions are intricately linked to the the regulation of immune
response, cell proliferation and apoptosis, cell differentiation and
polarization, cytokine secretion, or acts as tumor suppressors or
promoters. Understanding the role of ncRNAs in lung diseases might
provide novel insights into disease mechanisms and potential therapeutic
targets. In this review, we will go over the fundamental characteristics
and functions of miRNAs and lncRNAs, their potential interaction
mechanisms, then summarize the newly explorations on the role of these
interactions between lncRNAs and miRNAs in various lung diseases.
Thermal Chemistry and Decomposition Behaviors of Energetic Materials with Trimerizing Furoxan Skeleton
Authors: Zhou Jing , Zhang Junlin , Zhai Lianjie , Cao Yilin , Wang Xiaocong , Qiu Lili , Wang Bozhou , Meng Zihui
Published: January 2024

Trimerizing furoxans are ideal molecular skeletons for the construction
of high energetic substances due to their compact structures and high
enthalpy of formations. Herein, we reported the first systematic
research on the thermochemical behaviors and decomposition mechanism of
energetic trimerizing furoxan structures of
3,4-bis(3-fluorodinitromethylfuroxan-4-yl)furoxan (BFTF),
3,4-bis(3-cyanofurazan)furazan oxide (BCTFO) and benzotrifuroxan (BTF).
Both the substituted furoxan based energetic compounds (BCTFO and BFTF)
exhibited low melting points and complicated thermal decomposition
behaviors, while the melting point of unsubstituted furoxan (BTF) was
much higher. Their detailed mechanism were proposed based on the
experimental results through in-situ FTIR spectroscopy method and
DSC-TG-FTIR-MS quadruple technology, which indicated that the cleavage
of substituent would trigger the decompostions of BFTF and the
decompostion of trimerizing furoxan skeletons almost synchronous
occurrence with substituents in BCTFO. The self-oxidation-reduction of
the linear and annular trimerizing furoxans lead to similar
decomposition fragmented small molecule products.
MONKEY POX AND SEXUAL HEALTH
Authors: Udohchukwu Okereke , Terra Mohamed , Sospeter Sospeter Berling , Obumneme Okereke , Chidera Uche , Philemon Ugwuanyi , Daniel Ginger-Eke , Arinze Ibeh
Published: January 2024

Monkeypox is a viral disease with skin rashes and symptoms similar to
smallpox. Evidence suggests it can be sexually transmitted. This review
focuses on the current understanding of sexual transmission, clinical
manifestations, and roles of healthcare providers such as dentists and
clinicians. Limited data exists on sexual transmission, making it less
important for healthcare providers to consider it in patient management.
Dentists and clinicians should be aware of the clinical manifestations
and be vigilant for signs in patients with recent sexual contact. This
review highlights the importance of ongoing surveillance and research
into the sexual transmission of monkeypox and the role of healthcare
providers in its management.
ARHGAP18/SENEX enhances apoptosis resistance of B-cell non-Hodgkin lymphoma via inhibiting CDK4/6 to promote cellular senescence
Authors: Wang Jiyu , Yi Liuying , Huang Keke , Yangyang Wang , Wang Huiping , Zhai Zhimin
Published: January 2024

Background: Resistance to existing therapies is currently the main
reason for treatment failure in refractory/relapsed B-NHL patients, and
therapy-induced senescence (TIS) is one of the important mechanisms of
tumor drug resistance. Methods: Raji cells were transfected with the
human SENEX shRNA recombinant lentiviral vector (Si-SENEX) and the empty
vector negative (NC) to construct a stable transfection cell line with
knockdown of SENEX. Effect of SENEX-silencing on B-NHL-TIS formation,
cell function and cell cycle-related pathways was analyzed. We generated
TIS model (using doxorubicin (dox)-inducible senescent B-NHL cells)
combined with the specific CDK4/6 inhibitor Palbociclib (PAL) to observe
that blocking CDK4/6 effects on TIS formation. In addition, expression
levels of SENEX of 21 B-NHL patients and 8 healthy controls were tested
by qRT-PCR, and the correlation between its expression and clinical
indicators of patients was analyzed. Results: Downregulation of SENEX
expression promotes G1-S phase transition and inhibits TIS formation in
B-NHL cells to reduce the apoptosis resistance of B-NHL cells against
chemotherapeutic drug DOX. Blockade of CDK4/6 promotes the DOX-induced
G1 phase arrest to enhance TIS formation in B-NHL cells which can
reverse the regulatory effect of silencing SENEX on B-NHL cell cycle
regulation and senescence. Expression levels of SENEX in B-NHL patients
were significantly increased compared to healthy controls, and Elevated
expression levels of SENEX were associated with poor prognosis of B-NHL
patients. Conclusions: ARHGAP18/SENEX enhances apoptosis resistance of
B-NHL via inhibiting CDK4/6 to prevent G1-S phase transition and promote
TIS.
Thrixspermum yei M. K. Li, Z. Xing & Y. Luo (Orchidaceae) — a new species from Xizang, China
Authors: Li Mengkai , pang shenshen , yu yingpeng , chen xueda , deng jianping , wang wei , Luo Yan , xing zhen
Published: January 2024

A new species Thrixspermum yei is described and illustrated from Xizang,
China. It is similar to T. fantasticum and T. pygmaeum but quite
different from the two in having slender peduncle, white sepals and
petals, golden-yellow lip (margin entire, not lobed), which disk with
several tuberculate fleshy process, densely covered with yellow powder,
base with a round papillary projection.
Synthesis of Benzothioamide Derivatives from Benzonitriles and Sulfur-containing Ionic Liquids in Supercritical CO2
Authors: Sang Guozhi , Wang Xinchen , Feng Qianxi , Xie Ruijun , Li Zhuona , Hao Enlun , Li Ruonan , Zhu Ning
Published: January 2024

A simple, efficient and green method has been developed for the
synthesis of benzothioamide from benzonitrile in supercritical CO2,
which could be used to synthesize various benzothioamide derivatives
efficiently without organic solvent. Notably, some sulfur-containing
ionic liquids were prepared and they could promote the thiolysis of
benzonitrile to produce benzothioamide in an excellent yield. Moreover,
the investigation on the reaction mechanism showed that the acid-base
property of the reaction solution was key to the thiolysis of
benzonitrile mediated by the sulfur-containing ionic liquids.
Associations between polymorphisms of TNFSF13B and Primary Sjögren’s Syndrome susceptibility in Primary Sjögren’s Syndrome Patients: a Meta-analysis
Authors: Zheng Anhao , Hu Naiwen , Xu Jing , Yuan Ye , Zhang Shumin , Chen Wenbin , Bai Yanyan , Sun Hongsheng
Published: January 2024

Objective B cell activating factor (BAFF) is a key regulator of Primary
Sjögren’s Syndrome (pSS), which is characterized by B lymphocyte
hyperactivity. BAFF is also known as TNF ligand superfamily member 13B
(TNFSF13B). This study aimed to explore whether five single nucleotide
polymorphisms (SNPs) of the TNFSF13B gene (rs9514827, rs1041569,
rs9514828, rs1224141, and rs12583006) are related to pSS susceptibility.
Methods We searched Pubmed, Cochrane, Elsevier, Web of Science, CNKI,
CQVIP, and WanFang databases (up to January 2023). In a population with
pSS, the odds ratios (ORs) with 95% confidence intervals (CIs) of
genotypes and each allele were provided to investigate relationships
between the polymorphisms of the BAFF (TNFSF13B) gene and pSS. Results
The meta-analysis in question contains three studies. In the group of
pSS patients and randomly selected health controls (HCs), there was a
statistically significant relationship between rs1041569 and rs12583006
and pSS susceptibility, respectively. In fixed models, there were
statistical differences in pSS patients and randomly chosen HCs.
Conclusions There were relationships of rs1041569 and rs12583006 in the
pSS group and HC group. BAFF(TNFSF13B) genes, particularly rs1041569 and
rs12583006, were related to pSS susceptibility in pSS patients.
Fixing a detail on the typification of Lecythis zabucajo Aubl.
Authors: Silva Nilber
Published: January 2024

Lecythis zabucajo lectotype was proposed with a mistake regarding the
number of the plate. To fulfill the code, this detail is here fixed.
Peer interactions in 4/6-month-old infants: From motor development to multimodal communication
Authors: Cochet Hélène , CHENE Flore , Guidetti Michèle
Published: January 2024

Our goal was to explore the potential continuity between motor activity
observed in early social situations and communication development.
Thirteen infants between 4 and 6 months of age were observed in daycare
centers, either on their own or in dyads, and in two postural
conditions: lying on a playmat or seated in bouncers. Infants were found
to modify their posture, movements and gaze behavior in dyadic
situations compared to situations alone. Moreover, the bouncers
facilitated visual interactions while the playmat favored the production
of hand movements. This work highlights the need to analyze multimodal
characteristics of interactions and to add posture variations as a key
variable to better understand how infants develop communicative
intention toward their peers.
Computational Time-Based Comparative Analysis of Edge vs. Block-based Steganography of X-Ray Image using Matlab in the Region of No Interest (RONI) for Real-Time Applications
Authors: Sharma Divya , Prabha Dr. Chander
Published: January 2024

The main challenge is to hide a bigger data set of Electronic Medical
Images (EMI) of varying features such as sizes, dimensions, etc. into a
normalized cover image while achieving various objectives of
steganography such as increased payload capacity, imperceptibility,
security, reduced computational time, and complexity. This paper is
focused on enhancing the security of the EMI stored by hospitals, labs,
and so on while providing anywhere anytime access to them in Real time.
A data set of 5856 X-Ray medical images in JPEG format of varying
features has been hidden using two steganography methods Edge-Based
(EBS) and Block-Based (BBS). The secret X-Ray images are hidden across
the edges and blocks lying in the region of no interest (RONI) of the
normalized cover image one at a time. With the goal of reduction in
computational time and computational complexity which will lead to its
applicability in real-time applications (RTA). The RTA grants access to
EMI while using heterogeneous devices, therefore, increasing its
scalability, and usage. The results achieved are compared for before and
after steganography: a) comparison of secret X-Ray images, and b)
comparison of cover images using standard tests such as Mean Square
Error (MSE), Peak Signal to Noise Ratio (PSNR), Structural Similarity
Index Metrics (SSIM), Coefficient of Variation (CV), and Pearson
Correlation (R) values with the previously studied methods. Results
achieve a 100% embedding rate, SSIM value of 1, and low average MSE
value of 0.005 for EBS secret images and 0.003 for BBS secret images.
These results indicate that the usage of both methods is capable of
hiding large data sets in a single go within minutes and thus making
them applicable for RTA.
Effects of Myeloperoxidase on Inflammatory Responses with Hypoxia in Citrobacter rodentium-Infectious Mice
Authors: Gao Xiang , Zhang Yu , Zhu Qingfang , Han Ying , Jia Ruhan , Zhang Wei
Published: January 2024

Purpose: Myeloperoxidase(MPO) has been found to be the mediator in
various inflammatory diseases. Bacterial infection of the intestine and
hypoxia can both lead to inflammatory responses, but the effects of MPO
in these phenomena are still unclear. Methods: By building the MPO-/-
mice ，we examined relevant inflammatory factors and tissue damage in
mice with intestinal Citrobacter rodentium infection and hypoxia. The
body weight and excreted microorganisms were monitored. Intestinal
tissues were collected 7 days after bacterial infection under hypoxia to
undergo HE staining and assess the degree of pathological damage. The
levels of TNF-α, IFN-γ, IL-6 and IL-1β inflammatory factors in the serum
were quantified using ELISA. PCR, WB and IF assays to determine the
expression of chemokines MCP1, MIP2 and KC in the colon and spleen. .
Results: Citrobacter rodentium infection and hypoxia caused weight loss
, intestinal colitis and splenic inflammatory cells active proliferation
in wild type mice and this phenomena was alleviative in MPO-/- mice.
Also，the capability of clearing bacteria in MPO-/- mice significantly
declined. The level of TNF-α in the serum and spleen was both lower in
MPO-/- hypoxia C. rodentium-infected mice than that in wild type mice.
The chemokines expression levels of MIP2, KC and MCP1 in the spleen and
colon of each bacterial infected group were significantly increased
(P<0.05), while in hypoxia, the factors in the spleen and
colon were decreased (P<0.05). Meanwhile, The levels of these
chemokines in the MPO-/- mice were found to be lower than those observed
in the wild type mice. Conclusion: MPO plays an important role of the
inflammatory responses in infectious enteritis and hypoxia in mice. Loss
of MPO may greatly reduces the body’s inflammatory responses to fight
deseases.
Small-size composite Ni-Co/Mo2C/Co6Mo6C2@C prepared by a anchoring calcination strategy for efficient hydrogen evolution reaction in the acidic and alkaline conditions
Authors: Gu Jianxia , Zhu Ying , Zheng Haiyan , Sun Chun-Yi , Su Zhongming
Published: January 2024

A novel, cheap and high-efficiency nanocomposite Ni-Co/Mo2C/Co6Mo6C2@C
has been successfully constructed through simple one-step carbonization
method (N2). Due to the fact that polyethyleneimine (PEI) in the
precursor can effectively anchor molybdenum-based Keggin-type
polyoxometalate (PMo12) and layered double hydroxide (NiCo-LDH) through
electrostatic and coordination interactions, it can avoid the
aggregation of catalyst particles during the pyrolysis process. After
the optimization, the obtained Ni-Co/Mo2C/Co6Mo6C2@C possesses small
size (3-8 nm, concentrated at about 4.5 nm), large specific surface area
and hierarchical pore structure. More important, Ni-Co/Mo2C/Co6Mo6C2@C
presents remarkable hydrogen evolution reaction (HER) activity with low
overpotentials in 0.5 M H2SO4 (102.3 mV) and 1 M KOH (95 mV) to afford
the current density of 10 mA·cm-2, as well as small Tafel slopes of
82.49 mV dec-1 and 99.92 mV dec-1, respectively. Simultaneously, this
catalyst also shows outstanding stability for 12 h without significant
change in current density. Herein, such excellent catalytic performance
of Ni-Co/Mo2C/Co6Mo6C2@C can put down to the synergistic effect between
multiple components and the small size of the catalyst. This work
provides unique insights into the preparation of efficient transition
metal-based catalysts for HER.
A new species of Veronica (Plantaginaceae) from Western Iran
Authors: Advay Mahfooz , Albach Dirk , Doostmohammadi Moslem
Published: January 2024

Veronica kurdistanica is described and illustrated as a new species. It
grows on calcareous rocks in a few sites in an alpine area in western
Iran (Kurdistan province). The new species belongs to V. kurdica species
group and is putatively closely related to V. daranica, with which it is
com-pared. Veronica kurdistanica is distinguished from V. daranica
particularly by its glandular in-dumentum. Molecular phylogenetic
analysis of nrDNA (ITS) region confirms this relationship as it is
assembled in a sub-clade including V. daranica, V. khorassanica and V.
kurdica.
Construction of 1,3,4-oxadiazolines bearing CF3-quaternary cen-ter via amino-assisting cycloaddition of nitrile imines generated in situ with o-aminotrifluoroacetophenones
Authors: Zhu Yannan , Liu Jiaqing , Wang Yi-Ning
Published: January 2024

An amino-assisting [3+2] cycloaddition strategy of nitrile imines
generated in situ with o-aminotrifluoroacetophenones under mild
conditions has been constructed, in which a variety of
1,3,4-oxadiazolines bearing CF-quaternary centers can
be obtained in good to excellent yields. The MTT assay shows that the
resulting 1,3,4-oxadiazoline derivatives could be the potential
candidates for the treatments of head and neck cancers.
Identification of extracellular matrix proteins in plasma as a potential biomarker in the diagnosis of intervertebral disc degeneration
Authors: Nayagam Sharon , Ramachandran Karthik , Selvaraj Ganesh , Rajendran Sunmathi , Easwaran Murugesh , Palraj Narmatha Devi , S Srivijay Anand K , Muthurajan Raveendran , tangavel chitraa , Shanmuganathan Rajasekaran
Published: January 2024

Purpose: At the molecular level, disc degeneration (DD) has been
associated with dissociation of matrix assembly, leading to the loss of
structural integrity. As a result of matrix dissociation, tissue ECM
proteins are expected to leak into the newly developed blood vessels
that circulate in the peripheral blood, indicating diseased states.
Experimental design: To identify the IVD tissue-ECM proteins leaked into
diseased plasma, global proteomic analysis was performed on 10 healthy
volunteers (HV) and 10 diseased subjects (DS) after depletion of highly
abundant proteins such as Albumin and IgG. Results: 28 proteins were
identified as matrix-associated proteins identical to the proteins found
in intervertebral disc tissues. Of these, 26 were from DS and 21 from
HV. Among these candidates, aggrecan and fibulin 1 were found to be up
and downregulated significantly in the DS group. Interestingly, diseased
plasma had a specific expression of COL2A1, native to the nucleus
pulposus. Conclusions and clinical relevance: The upregulated and unique
presence of aggrecan and collagen type 2A1 respectively in diseased
plasma remains indicative of intervertebral disc disease progression.
This identification could aid in understanding the altered protein
signature that remains indicative of tissue damage and the circulation
of damaged tissue products.
SQSTM1/p62 as a prognostic marker promotes the progression of gastric cancer through epithelial-mesenchymal transition.
Authors: Xu Yan , Zhu Chenglou , Ji Dandan , Wu Qiong , Peng Lingzhi , Bai Pengwei , Bai Zhaozhao , Da Mingxu
Published: January 2024

Background: SQSTM1/p62 is an autophagy-related receptor protein that
participates in regulating tumorigenesis and multiple signaling
pathways. Gastric cancer is a common tumor in the digestive tract and
continues to pose a significant threat to human health. Therefore, this
study aims to investigate the impact of p62 on gastric cancer. Methods:
Immunohistochemistry and Western blotting were employed to assess the
expression level of the p62 protein in gastric cancer tissues and its
correlation with prognosis. Subsequently, in vitro cell experiments were
conducted to determine the role of p62 in gastric cancer cell
proliferation, migration, and metastasis. Result: The expression of p62
in gastric cancer tissues was significantly higher than in normal
tissues. The expression of p62 was positively correlated with poor
prognosis in gastric cancer patients. In vitro cell experiments
indicated that p62 promotes gastric cancer cell proliferation and
migration. Mechanistically, elevated p62 expression induced
epithelial-mesenchymal transition (EMT), leading to upregulation of
E-cadherin and downregulation of N-cadherin and vimentin. Conclusion:
This study provides novel and robust evidence for the mechanism by which
elevated p62 expression promotes the progression of gastric cancer. It
offers promising therapeutic targets for anti-tumor treatment strategies
in gastric cancer patients.
The Affective, Cognitive, and Physiological Effects of Implementing Antecedent-Focused Emotion Regulation Strategies in Childhood
Authors: Davis Elizabeth , Brady Shannon , Pankratz Kasey , Tolman Zariah , Parsafar Parisa , Shih Emily
Published: January 2024

Different components of emotional responding may be affected by using
specific emotion regulation strategies that enable children’s volitional
self-regulation. This study examined the affective, cognitive, and
physiological effects of experimentally instructing children to deploy
distraction and reappraisal to regulate negative emotion during an
evocative film clip. One-hundred eighty-four 4- to 11-year-old children
(M = 7.66 years; SD = 2.33 years; 94 girls) participated. Neither
strategy affected observed distress or self-reported negative emotion.
Relative to a control condition, children instructed to use reappraisal
reported marginally less happiness after the emotional film and
attenuated rumination. Distraction also predicted attenuated rumination,
as well as a pattern of parasympathetic reactivity indicative of
disengagement that correlated with parents’ reported use of minimizing
and punitive emotion socialization practices. Findings underscore the
utility of multi-method approaches that examine parasympathetic activity
in conjunction with volitional measures of self-regulation.
SMART WINDMILL and WIND SOLAR TREE
Authors: Singh Kamlesh , Singh Rohit , Singh Prateek , Singh Brijbhan
Published: January 2024

* The present invention relates to the harnessing of green and renewable
energy. And various methods to maximize such energy generation efforts
in a micro power plant model. Also explores the description of a smart
windmill, for green energy generation purposes, combined with Solar
panels.
The experimental study of mir-99a-5p negative regulation of TLR8 receptor mediated-mediated innate immune response in rabbit knee cartilage injury
Authors: Zhang Jiebin , Zheng Ke , Wu Yichao , Zhang Shengting , Guo Ao , Sui Cong
Published: January 2024

Background:Traumatic cartilage injury is an important cause of
osteoarthritis (OA) and limb disability, and Toll-like receptors (TLRs)
mediated innate immune response has been confirmed to play a crucial
role in cartilage injury.In the previous study, we found that the
activation of TLR8 molecules in injured articular cartilage was more
obvious than other TLRs by establishing an animal model of knee impact
injury in rabbits, and the changes of TLR8 molecules could significantly
affect the process of articular cartilage injury and repair. Objective:
To verify how mir-99a-5p regulates TLR8 receptor mediated innate immune
response to treat traumatic cartilage injury. Methods: The impact of a
heavy object on the medial condyle of the rabbit’s knee joint caused
damage to the medial condylar cartilage. Through pathological and
imaging analysis, it was demonstrated whether the establishment of an
animal model of traumatic cartilage injury was successful. Establishing
a cell model by virus transfection of chondrocytes to demonstrate the
role of TLR8 in the innate immune response to impact cartilage injury.
Through transcriptome sequencing, potential targets of TLR8, mir-99a-5p,
were predicted, and basic experiments were conducted to demonstrate how
they interact with innate immune responses to impact cartilage damage.
Results:TLR8 is a receptor protein of the immune system, which is widely
expressed in immune cells. In our study, we found that TLR8 expression
is localized in lysosomes and endosomes.Mir-99a-5p can negatively
regulate TLR8 to activate PI3K-AKT molecular pathway and aggravate
cartilage damage.Inhibiting TLR8 expresson can effectively reduce the
incidence of articular cartilage damage. Conclusion:Based on the results
from this study, mir-99a-5p may be an effective molecular marker for
predicting traumatic cartilage injury and targeting TLR8 is a novel and
promising approach for the prevention or early treatment of cartilage
damage.
a Novel Technique based Intensive Binary Pigeon Optimization ( IBiPO) & Bi-LSTM-based IDS Framework
Authors: Nabi Faisal , Zhou Xujuan
Published: January 2024

With the global adoption of Internet services, service providers are
having a difficult time securing their systems, especially against new
attacks and intrusions. Various anomalous detection approaches have been
developed for protecting WSN from cyber-attacks. However, those systems
suffer from the major issues of a high number of false alarms, increased
over-fitting, and complexity. Therefore, this paper motivates to develop
a novel and intelligent IDS framework for protecting WSN from
cyber-attacks. For this purpose, an Intensive Binary Pigeon Optimization
(IBiPO) and Bi-directional Long Short Term Memory (Bi-LSTM) mechanisms
are developed for accurate intrusion detection and classification.
Effects of Clustered Care on Comfort Levels and Physiological Parameters of Premature Infants
Authors: ÖZKILIÇASLAN FATMA TOKAN , GEÇKİL EMİNE
Published: January 2024

This study evaluates the effect of clustered care based on
individualized developmental care on comfort level and physiological
parameters of premature infants in the intensive care unit. In the
study, data of 128 premature infants born between 28 and 37 weeks of
gestation were collected. Individualized clustered care was applied to
the infants and the results were analyzed. According to these results,
there was a significant increase in the comfort levels of the infants
with the implementation of clustered care. In addition, it was found
that there was no difference in the heart rate and respiratory rate of
the infants immediately after the clustered care, but one hour after the
clustered care, both respiratory rate and heart rate decreased
significantly. These results suggest that clustered care based on
individualized developmental care can increase the comfort level and
improve the physiological parameters of infants.
Potential mechanisms of action of the gut microbiota in antitumour immunity and immunotherapy
Authors: Yin Qian , Ni Jiao-Jiao , Ying Jie-er
Published: January 2024

The gut microbiota significantly impacts antitumour immunity and alters
the effectiveness of cancer immunotherapy. Immunotherapies, notably
inhibitors of immune checkpoints that target programmed death 1 (PD-1)
and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)， have
profoundly changed the way advanced and metastatic cancer is treated and
dramatically improved overall and progression-free survival. However,
the underlying molecular mechanisms by which the gut microbiota affects
antitumour immunity and the efficacy of cancer immunotherapy remain
elusive. In this review, we summarize the latest knowledge supporting
the associations among the gut microbiota, antitumour immunity, and
immunotherapy. The potential molecular mechanisms underlying these
associations are explained in terms of four aspects.
The effect of flow sampling on the robustness of the actuator line method
Authors: Zormpa Markella , Arcos Federico Zilic de , Chen Xiaosheng , Vogel Christopher , Willden Richard
Published: January 2024

The actuator line method (ALM) is a widely-used tool for the modelling
of horizontal axis turbines and wind and tidal farm flows. The method
uses a virtual blade representation to simulate the dynamics of wind
turbines without the computational expense associated with resolving the
blade geometry. Within the ALM the flow is first sampled at each blade
section, allowing for the calculation of the sectional lift and drag
forces that are in turn imposed on the flow domain using a smearing
kernel. In this work the effect of the flow sampling method on the
robustness of the ALM is discussed. Implementations of two widely-used
types of methods for horizontal axis wind turbines are tested: point
sampling, where the flow is sampled at or near the collocation point,
and volume average sampling where flow field information from multiple
points centered at the collocation point is averaged into a
representative blade-local velocity vector. A third method, line average
sampling, that was initially proposed for sampling flows from blade
resolved simulations is adapted for the ALM framework. This method
samples the flow symmetrically around a control element in order to
eliminate the interference of the bound circulation, thus allowing the
inflow velocity at the aerofoil to be determined. When evaluating power
and thrust coefficients as well as the flow field at the rotor plane
predicted by the ALM, the line average sampling approach is demonstrated
to be more robust and converges faster with time step for two different
rotors: a small wind rotor and a high solidity tidal rotor. This
suggests that carefully selecting the sampling method could be key in
alleviating the very strict time step restriction imposed by the ALM, a
widely acknowledged limitation of the method. Such an advancement could
contribute towards improving the computational efficiency and
tractability of the method.
A Study on Efficient Information Security using Elliptic Curves
Authors: Kaur Hargeet , Sanghavi Jay , Vakil Abhi , Shah Shrey
Published: January 2024

Nowadays, Internet of Things applications today use hardware security
modules to ensure secure communication. The elliptic curve is a
fundamental aspect of contemporary cryptography. Due to its smaller key
requirement than other public key algorithms, the elliptic curve is
frequently used in wireless installations, mobile networks, and credit
cards. Elliptic Curve Cryptography has the advantage of increasing
system performance, utilising fewer resources, and providing security
for a smaller key than other techniques. The technique of Elliptic Curve
is carefully studied in this article by developing a categorization
based on previous analyses and evaluations in this subject.
Study on the mechanism of miRNAs on liver injury in the condition of protoscocephalus alveolarus transhepatic portal vein infection
Authors: Zhu Yazhou , Li Ming , Li Zihua , Song Jiahui , Zhao Wei
Published: January 2024

Echinococcus multiloculasis is a zoonotic parasitic disease caused by
Echinococcus multilocularis, which can cause liver injury, but the
mechanism of liver injury is still unclear. Here, Echinococcus
multilocularis was injected via the hepatic portal vein to establish a
mouse model of infection, and high-throughput RNA sequencing was
performed for detecting the expression of miRNAs in the liver of mice
infected with 2000 Echinococcus multilocularis after 3 months infection,
in order to understand the potential molecular mechanism of liver injury
caused by Echinococcus multilocularis infection. Overall, 71
differentially expressed miRNAs were found in liver in comparison with
control and a total of 36 mouse miRNAs with
|FC|>0.585 were screened out,
respectively. In addition, Targetscan (V5.0) and miRanda (v3.3a)
software were used to predict differential miRNAs target genes and
functional enrichment of target genes. Functional annotation showed that
“cytokine-cytokine interaction”, “ positive regulation of cytokine
production”, “ inflammatory respose”, “ leukocute activation” were
enriched in the liver of Echinococcus multilocularis-infected mice.
Moreover, the pathways “human cytomegalovirus infection”, “cysteine
and methonine metabolism”, “Notch signaling pathway” and
“ferroptosis” were involved in liver disease. Furthermore, 4 miRNAs
(mmu-miR-30e-3p, mmu-miR-203-3p, mmu-miR-125b-5p and mmu-miR-30c-2-3p)
related to liver injury were screened and verified. This study revealed
that the expression profiling of miRNAs in the livers was changed after
Echinococcus multilocularis infection, and improved our understanding of
the transcriptomic landscape of hepatic echinococcosis in mice.
A study of the near wake deformation of the X-Rotor vertical-axis wind turbine with pitched blades
Authors: Bensason David , Sciacchitano Andrea , Ajay Adhyanth Giri , Ferreira Carlos Simao
Published: January 2024

Recent studies have revealed the large potential of
vertical-axis wind turbines (VAWTs) for high-energy-density wind farms
due to their favorable wake recovery characteristics. The present study
provides an experimental demonstration and proof-of-concept for the wake
recovery mechanism of the novel X-Rotor VAWT. The phase-locked flowfield
is measured at several streamwise locations along the X-Rotor’s wake
using stereoscopic particle image velocimetry (PIV) with fixed-pitch
offsets applied to the blades. The streamwise vortex system of the upper
half of the X-Rotor is first hypothesized and then experimentally
verified. The induced wake deformations of the vortex systems are
discussed in comparison with previous studies concerning traditional
H-type VAWTs. The results suggest that positive blade pitch is more
favorable for accelerated wake recovery due to the dominant tip-vortex
generated on the upwind windward quadrant of the cycle. Utilizing
theoretical blade load variations along the span explains distinct
unsteady flow features in the near wake generated at select quadrants of
the rotor rotation, shedding light on the potential of the two pitch
schemes.
The role of the interleukin family in neuroinflammation caused by substance dependence
Authors: Fan Xuan
Published: January 2024

Drug abuse is a universal phenomenon that happens across the world. And
the neurotoxicity caused by drug abuse in the central nervous system has
been extensively studied during the last decade. More recently, the role
of drugs causing neuroinflammation, which would subsequently affect
dopaminergic neurotoxicity, has aroused wide attention. This paper aims
to present a literature review of the studies on the role of the
interleukin family in substance-dependent neuroinflammation. Currently,
the most studied cytokines in the interleukin family in the drug field
are IL-1 and IL-6. In addition, based on the previous literature on
changes in interleukin in neuroinflammation induced by different drugs,
this paper identifies neuroinflammation-related diseases caused by
interleukin families, and summarizes recent advances in the dynamics,
mechanisms, immunomodulatory and anti-inflammatory effects that are
related to the pathogenesis of these diseases. In conclusion, this
review elucidates substance-dependent neurotoxicity from the perspective
of interleukin alterations.
Experimental validation of virtual torque sensing for wind turbine gearboxes based on strain measurements
Authors: Bosmans Jelle , Gallas Simone , Smeets Victor , Kirchner Matteo , Geens Luk , Croes Jan , Desmet Wim
Published: January 2024

In efforts to reduce the operation and maintenance cost of wind
turbines, there is an increasing interest to monitor key turbine
quantities such as the torque load on the gearbox. Monitoring the torque
paves the way for the calculation of remaining useful lifetime, leading
to cost reductions through improved reliability and maintenance
planning.In order to avoid expensive direct torque sensors,
this paper investigates the potential of virtual torque sensing, a
technique based on 3 basic components: firstly, a set of
non-intrusive sensors installed on the gearbox. Three groups of strain
gauges on the gearbox as well an angular encoder are considered in this
paper. Secondly, a physics-based model, capable of predicting the
response of aforementioned sensors. These models are constructed with a
purposeful balance between accuracy and computational cost. Model
validation and updating are performed to ensure efficient and accurate
prediction of the sensor output. Finally, an Augmented Extended Kalman
Filter (AEKF) is used to combine the measured response with predictions
from the model to infer the gearbox input torque. Since a key factor
determining the performance of the AEKF is the tuning of the AEKF
covariance matrices, multiple methods are introduced to systematically
tune the covariance matrices.Experimental validation results
show that the virtual torque sensor can detect the load torque with a
Normalized Mean Absolute Error (NMAE) between 3 .41%
to 7 .47% , depending on the sensor set. The
influence of the amount of sensors used and the tuning method are also
investigated.
Investigation of H∞ -Tuned Individual Pitch Control for Wind Turbines
Authors: Henry Aoife , Pusch Manuel , Pao Lucy
Published: January 2024

Large wind turbines experience amplified asymmetrical loads at
particular harmonics of the rotational frequency. Individual pitch
control (IPC) has emerged as a potential controls solution to this
problem. H ∞ control, which facilitates robust, multivariable controller
synthesis in the frequency domain, is a candidate approach to IPC design
for several reasons. Firstly, the objectives of asymmetrical load
attenuation are best described in the frequency domain. Secondly, the
IPC control signals and loads in orthogonal directions are coupled,
which necessitates a multivariable controller approach. Thirdly, H ∞
synthesis is a method that can explicitly impose constraints on the
robustness of the closed-loop system. A downside of IPC is the
significant increase in blade-pitch travel incurred, which introduces
additional loading on the blade-pitch bearings over time. We investigate
strategies to constrain the blade-pitch travel in the controller tuning
procedure. A comprehensive study is thus presented for a range of H ∞
-synthesized IPCs to attenuate asymmetrical loads on large rotors at
harmonics of the rotational frequency while mitigating blade-pitch
travel. All developed controllers are validated and compared using a 25
MW fixed-bottom offshore wind turbine model via linear analysis of the
robustness of the closed-loop system to input and output disturbances
and nonlinear analysis via the study of structural load power spectra,
damage-equivalent loads (DEL), and the actuator duty cycle (ADC) of the
blade-pitch actuator.
Extending vase life of blue water lily (Nymphaea stellata) using different preservative solutions
Authors: Kumara Aruna , Thiruchchekvan Nagarathnam
Published: January 2024

The experiment was conducted to find out the effect of different
preservative solutions to extend the vase life of blue water lily
(Nymphaea stellata). Experimentation was arranged in a complete
randomized design (CRD) with eight treatments along with distilled water
used as the control treatment and each treatments replicated thrice. A
preliminary trial was conducted to find out the best chemical solution/s
and experiment 2, best concentrations using Al2 (SO3)4 200ppm, Clorox
0.5%, and Sugar 2.0% under laboratory conditions (23 ⁰C) with
continuous light intensity of two florescent bulbs. The best
concentration/s selected in the preliminary trail was used for next
experiment. Non-parametric data, such as wilting of petals and sepal,
sepal color, petiole rigidity, petiole color, were recorded based on the
visual observations and the data were analyzed using statistical
analysis system (SAS). Results reveled, cut flowers treated with
combination treatment under laboratory condition, Al2(SO3)4 200ppm and
Clorox 0.5% + sugar 2.0% of distilled water at 23⁰C were the best
solutions to lengthen the vase life of blue water lily flowers up to
seven days from harvest.
Mendelian randomization for autoimmune diseases: exploring causal links and drug targets in plasma proteome
Authors: Ma xinling , Zhao Qi-Gang , Xu Qian , Song Zi-Tong , Bu Fan , Li Kuan , Zhang Lei , Pei Yu-Fang
Published: January 2024

Background: Autoimmune diseases (ADs) have serious impacts on
the quality of life of patients and for which with no ideal treatment.
The plasma proteome represents a major source of druggable targets. We
aimed to identify plasma proteins as potential therapeutic targets for
ADs. Methods: We performed two-sample Mendelian Randomization
(MR) to explore the causal relationship between 4,907 plasma proteins
(N=35,559) and six ADs (N ranged from 23,210 to 173,981) and further
validated using another independent plasma proteomic dataset (N=10,708).
Five methods were used to evaluate the causal effects, including inverse
variance weighted, MR egger, weighted median, simple mode and weighted
mode. Sensitivity analysis and reverse MR analysis were conducted to
evaluate the robustness of MR results and druggability analysis was used
to identify potential drug targets. Results: A total of 24
plasma proteins associated with ADs were identified in the discovery
dataset, of which 11 were successfully validated in replication sample.
The genetically predicted ARC1B, FcRIIIa, MAPK2 and Collagen II were
associated with type 1 diabetes, rheumatoid arthritis, inflammatory
bowel disease and celiac disease, respectively. The genetically
predicted TBPL1 and DEFI6 were associated with systemic lupus
erythematosus. IL-2 sRa, MICB, FTMT, FCAMR and SLAF1 were associated
with multiple sclerosis. No reverse causation existed. The druggability
analysis showed that IL-2 sRa has become an approved drug target and
FcRIIIa and MAPK2 are in clinical trials. Conclusions: The
identified proteins might be promising drug targets for ADs and warrant
further mechanistic studies.