bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Qi-Shao-Tong-Mai-An-Shen (QSTMAS) Herbal Paste in Coronary Heart Disease Patients with Depression and/or Anxiety: A Randomized Controlled Clinical Trial Protocol
Authors: CHEN Ying , Xiao Xiang , Xue Chongxiang , Zheng Shuliang , He Qing , Yao Ruiqi , Zhang Gaoyu , Huang Li
Published: January 2023

Background
Coronary heart disease (CHD) is a major disease threatening human life and health. Psycho-cardiology diseases aggravate not only the burden of finance but also the progression of CHD. Nowadays, a growing chorus of cardiovascular experts have come to call for an emphasis on the prevention and control of psycho-cardiology. Due to intricate adverse effects of antidepressants, it is urgent to explore a safe and effective early intervention method for psycho-cardiology diseases. Our medical team sought help from traditional Chinese medicine (TCM) and planned to explore the use of QSTMAS herbal paste in the treatment of CHD patients with Qi deficiency and blood stasis syndrome combined with depression and/or anxiety.
Methods
The single-blind, single-center, randomized controlled trial is designed to recruit 99 patients from China-Japan Friendship Hospital. All patients will be randomly assigned in a 1:2 radio. Both groups will receive standard western medicine treatment for CHD. The test group 2 will be treated with an additional 30ml QSTMAS herbal paste, orally twice daily for up to 12 weeks. The primary endpoints of the study are the changes in GAD-7 and PHQ-9 scores before and after the 12 weeks of intervention. The secondary endpoints included the clinical efficacy of TCM Syndromes of CHD, 6-minute walking test (6MWT), ISI Sleep Scale, laboratory tests, and examinations of the two groups before and after the 12 weeks intervention.
Discussion
QSTMAS herbal paste is a potential and promising treatment option for the treatment of mild and moderate psychological disorders in the cardiology department. The strict trial design will ensure the objective and scientific evaluation of the clinical efficacy and safety of the combination of QSTMAS herbal paste and standard western medicine in the treatment of CHD patients with Qi deficiency and blood stasis syndrome combined with depression and/or anxiety.
Trial registration:
China Clinical Trial Registry, ChiCTR2200065179, Version 2.0, Registered on 31 October 2022. http://www.chictr.org.cn/listbycreater.aspx.
French AmbUlatory cesarean section (FAUCS) versus low-segment cesarean section: Operative and postoperative complications, a retrospective comparative study.
Authors: Shqara Raneen Abu , Mustafa Susana Mikhail , Francis Yara Nakhleh , Sgayer Inshirah , Aiob Ala , Wolf Maya Frank , Lowenstein Lior
Published: January 2023

Purpose
We compared operative and postoperative results of French AmbUlatory cesarean section (FAUCS) and low-segment cesarean section (LSCS).
Methods
This retrospective cohort study assessed operative and postoperative results of 125 women who underwent FAUCS and 172 women who underwent LSCS in a tertiary hospital in Israel, during a one-year period.
Results
For the FAUCS compared to the LSCS procedure, the overall median operation time was 5min longer and the cutting time - fetal extraction interval was 3min longer. Smaller proportions of women who underwent FAUCS than LSCS had excessive intraoperative blood loss, defined as > 1000ml (2.4% vs. 9.3%, p = 0.017), a hemoglobin drop > 3gr/dL (1.6% vs. 7.6%, p = 0.029) and needed iron transfusion for postoperative hemoglobin < 7 gr/dL (0.8% vs. 7%, p = 0.009). The groups were similar in baseline characteristics, rates of intra-operative complications, blood transfusion, surgical site infection, endometritis, ileus and postpartum hemorrhage. The sum of postoperative complications was lower in FAUCS than LSCS (1.6% vs. 8.7%, p = 0.010). Early mobilization and spontaneous urination were achieved at a median of 5h (range 3–9) following FAUCS, and 18h (range 10–24) following LSCS. The median 24h pain visual analogue score was lower after FAUCS than LSCS (1.2 vs. 2, p < 0.001).
Conclusion
The operation was slightly longer in FAUCS than LSCS, but without clinical significance. Blood loss was less and postoperative complications were less frequent in FAUCS than LSCS. Our FAUCS protocol achieves early mobilization, early spontaneous urination and lower pain than LSCS at 24h.
Realizing neuromorphic networks at self-organized criticality on a 2D hexagonal BN platform
Authors: Nukala Pavan , Rao Ankit , Sanjay Sooraj , Ahmadi Majid , Venugopalrao Anirudh , Bhat Navakanta , Kooi Bart , Raghavan Srinivasan
Published: January 2023

Networks and systems which exhibit brain-like behavior can analyze information from intrinsically noisy and unstructured data with very low power consumption. Such characteristics arise due to the critical nature and complex interconnectivity of the brain and its neuronal network. We demonstrate that a system comprising of multilayer hexagonal Boron Nitride (hBN) films contacted with Silver (Ag), that can uniquely host two different self-assembled networks, which are self-organized at criticality (SOC). This system shows bipolar resistive switching between high resistance (HRS) and low resistance states (LRS). In the HRS, Ag clusters (nodes) intercalate in the van der Waals gaps of hBN forming a network of tunnel junctions, whereas the LRS contains a network of Ag filaments. The temporal avalanche dynamics in both these states exhibit power-law scaling, long-range temporal correlation, and SOC. These networks can be tuned from one to another with voltage as a control parameter. For the first time, different neuron-like networks are realized in a single CMOS compatible, 2D materials platform.
Convergence With Respect to Admissible Sequences of Weights for a Holomorphic Space of a Sequence of Hilbert-valued Rational Functions
Authors: Thuan Quang Thai
Published: January 2023

Let D⊂ CN be a domain, H be a locally convex space with the topology defined by a sequence of Hilbert semi-norms. Denote H(D,H) the space of H-valued holomorphic functions on D and R(CN,H) the space of H-valued rational functions on CN. In this paper, we set up terminology of an admissible sequence W = {wm}m≥1 of weights for H(D, F) and study sufficient conditions on W to ensure convergence of wm(||rm-f||m2) (pointwise/ in capacity/ uniformly on compact subsets) to 0 on the whole domain D except for a pluripolar subset provided the pointwise (rapid) W-convergence of {rm-f}m≥1 to 0 occurs on a Borel non-pluripolar subset X for every f ∈ H(D,H) and {rm}m≥1 ⊂ R(CN,H), in both of cases X lies in D, and X lies in the boundary ∂D of a bounded domain D.
Date: January 01, 2023. 2020 Mathematics Subject Classification. 41A20, 46G20, 31C10, 31C15
Accuracy of screening for HBV (NAT, HBSAg, anti-HBC) in blood donors from the Brazilian Amazon from 2105 to 2018
Authors: Belota Rosa Cristina Caldas , Silva Jean Melo , Nascimento Eduardo Luiz , Abrahim Cláudia Maria Moura , Castilho Márcia Costa , Neto José Pereira Moura , Albuquerque Sérgio Roberto Lopes
Published: January 2023

Background
Hepatitis B (HBV) is an infectious disease of worldwide importance and of great interest to transfusion medicine. The Amazon region has areas of high endemicity, outlining a worrying scenario for local transfusion safety, and it is necessary to investigate its impact on public health and blood component stocks.
Objective
To investigate the accuracy of HBV screening (NAT, HBSAg, anti-HBC) in blood donors from the Hemocentro do Amazonas, Brazil, from 2105 to 2018.
Methods
Blood donors reactive in serological and molecular screening for HBV were tested for viral load detection using the qPCR method at the reference center for liver diseases in the State of Amazonas to verify the accuracy of the screening established in Brazilian blood centers.
Results
A total of 230,591 blood donations were analyzed, with detection of 3,932 inaptitudes by serological and molecular tests, of which 3,104 samples were reactive for some marker for HBV (78.94%). Among the results found, no detection of viral load was observed in 100% of donors reactive to HBsAg alone, while 100% of donors with the NAT-/HBsAg+/Anti-HBc + profile had a detectable viral load.
Conclusion
The positivity for some HBV marker in blood donors was the biggest reason for discarding blood bags in the period; Serological and molecular screening proved to be safe and reliable; The evasion of individuals from continuing the investigation at the referral center can impact the epidemiological control of hepatitis B.
Denoising Astronomical Images with an Unsupervised Deep Learning Based Method
Authors: Liu Tie , Quan Yuhui , Su Yingna , Guo Yang , Liu Shu , Ji Haisheng , Hao Qi , Gao Yulong
Published: January 2023

Image denoising by deep learning has made great breakthroughs in recent years. However, previous deep learning methods cannot quantitatively control the deviation of the denoised images relative to the initial images, which may smooth the fine structures of small scale and change the original image information. We explore denoising astronomical images by the improved self-supervised neural networks `Self2Self', which can be trained on a single image. In order to control the deviation, we restore the abnormal pixels whose change of the absolute value is greater than a presetting value R after denoising. The value of R is usually less than the noise level of the image. By controlling R, we can obtain denoised images that match the original images to a reasonable requirement. After training, denoising and restoring (abbreviated as TDR-method), the noise level of the line-of-sight solar magnetograms observed by the space-borne Helioseismic Magnetic Imager is improved from about 8 G to 2 G without reducing the temporal and spatial resolutions. Further we denoise galaxy images obtained by the Hubble Space Telescope to demonstrate the universality of the TDR-method, and find that the signals of the galaxy structures are extended to weaker intensity. The TDR-method can make weak signals distinguishable by reducing the noise level, which can be applied to many disciplines.
Using machine learning in learner corpus research: error annotation and (extra-)linguistic metadata as proxies for approaching the interlanguage
Authors: Tantos Alexandros , Kosmidis Kosmas
Published: January 2023

This article investigates the potential of using error-annotated L2 utterances and their associated language profile to more accurately assess the language proficiency of an L2 learner. The main goal of this paper is to demonstrate the use of machine learning methods for uncovering features of the learner's interlanguage and their proficiency level, as well as to answer three questions: a) is it feasible to use error-annotated data along with linguistic profile metadata to trace patterns related to aspects of learners’ interlanguage? b) How important may error annotation be in estimating the learner’s proficiency level? c) Which of the (extra-)linguistic profile metadata stand out in contributing to the correct classification of the proficiency level? GLCII, the largest online freely available L2-Greek corpus, is utilized as an example corpus to illustrate the approach proposed in this paper with which for any L2, central questions can potentially be addressed by the relevant machine learning method so that, in a second stage, useful conclusion can be drawn. As a final point, we urge the implementation of ML techniques as a way of expediting research in a variety of related areas in applied linguistics.
Mobilization of Inflammasome Components for
Anaphylactic Degranulation by Mast Cells
Authors: Abraham Soman , Mencarelli Andrea , Bist Pradeep , Choi Hae Woong , Khameneh Hanif , Mortellaro Alessandra
Published: January 2023

Inflammasome components, NLRP3 and ASC are cytosolic proteins which upon sensing endotoxins/danger cues, form multimeric complexes to process IL-1β for secretion. Here, we reveal that the iconic IgE/antigen (Ag) mediated mast cell (MC) degranulation, an activity independent of IL-1β secretion is mediated by NLRP3 and ASC. IgE/Ag stimulated NEK7 and Pyk2 kinases induce NLRP3 and ASC deposition on granules forming a distinct protein complex (granulosome) to chaperone granules to the cell surface. MCs deficient in NLRP3 or ASC fail to form granulosomes, degranulate poorly in vitro and fail to evoke systemic anaphylaxis in mice. IgE/Ag-triggered anaphylaxis is prevented with an NLRP3 inhibitor. Interestingly, in endotoxin primed MCs, pro-IL-1β is rapidly packaged into granules after IgE/Ag stimulation and processed within granule remnants by proteases after degranulation, causing lethal anaphylaxis in mice. During IgE/Ag mediated degranulation of endotoxin primed MCs, granulosomes promote degranulation combined with exteriorization and processing of IL-1β resulting in severe inflammation.
Effects of interaction of Epichloë gansuensis and Bacillus strains on the seed germination and seedling growth in Achnatherum inebrians plants
Authors: Zhao Haiting , Nie Xiumei , Zhang Wu , Zhang Xingxu , Ju Yawen , Li Yanzhong , Christensen Michael John
Published: January 2023

Previous studies have confirmed that Bacillus and also Epichloë fungal endophytes can promote seed germination of grasses and induce stress resistance. However, the effects of interactions between Bacillusand endophyte on seed germination and seedling growth of grasses have not been well studied. In this study, Epichloë gansuensis endophyte-infected and endophyte-free Achnatherum inebrians seeds, and two month old seedlings, were inoculated with 12 Bacillus strains, and then effects of the treatments on four germination indicators and eight growth parameters were determined. The results showed that the interaction between E. gansuensis and Bacillus strains significantly (P<0.05) increased seed germination and the growth of A. inebrians. Interestingly, Bacillus strain inoculation, except for strain B96, provided a greater increase in growth on the 2-3 month old seedlings than the increase of growth with young seedlings. The germination rate of A. inebriansinoculated with the 12 strains ranged from 93.7% to 99%. Compared with other strains, B18 and B419 showed greater increases in growth of 2-3 months old plants. Moreover, the study employed a membership function value to assess the growth-promoting ability of the 12 Bacillusstrains on A. inebrians as an integrative tool for screening strains. Among the 12 strains, the B419 strain showed the best growth-promoting ability, while B106 was the worst strain. These results indicate that the B419 strain has potential value in agricultural production, and mechanisms of plant growth promotion will be further studied.
Urea treatment of mature whole-crop cereal mixtures as salvage forage for small-scale dairy systems in the dry season
Authors: Zamora-Juárez Yessica Guadalupe , López-González Felipe , Martínez-García Carlos Galdino , Arias-Ávila Monica , Arriaga-Jordan Carlos M.
Published: January 2023

Forage from small-grain cereals is an option to diversify feeding strategies in small-scale dairy systems (SSDS), due to their short cycle and ample adaptation. Mixtures of cereal species may have synergic advantages; however, grazing or ensiling are not always possible due to climatic factors, so that forage crops are left to mature and lose quality. Urea treatment of whole-crop mature cereal mixtures may be an option to salvage forage that could not be grazed or ensiled. The objective was to evaluate the performance of dairy cows fed urea-treated mature whole-crop forage mixtures of triticale (TRT), rye (RYE), and barley (BLY), in the dry season for SSDS. Treatment mixtures were TRT+RYE, TRT-BLY, and RYE+BLY. Fully mature cereal mixtures crops were treated with 4 - 6% granular urea (plus water) on a fresh basis. Forage variables were analysed with a split-plot design. Whole-crop forage yields were 3.4 ton/ha, with highest yields for RYE-BLY. Crude protein content increased two-fold in treated forages, and dry matter digestibility was moderate with a mean estimated ME content of 7.9 MJ ME/kg DM. Performance was evaluated by an on-farm 3x3 Latin square experimental design repeated 3 times with nine Holstein cows. Cows were offered daily 9.0 kg DM of urea treated forage; complemented with 4.4 kg DM of concentrate, day-grazing, and 1.5 kg of cut pasture. There were no statistical differences (P>0.05) for any of the animal variables. Urea treatment of whole-crop mature cereal mixtures resulted in a complementary moderate quality salvage forage for the dry season.
Single sporadic deceleration during reactive nonstress test – clinical significance and risk for cesarean delivery
Authors: weinberger hila , Nekave Shlomit , Hallak Mordechai , Gabbay-Benziv Rinat , Naeh Amir
Published: January 2023

Purpose: The non-stress test (NST) is the most widely applied technique for antepartum fetal assessment with the goal to reduce stillbirth. The evidence regarding the clinical significance of a single sporadic variable deceleration (SSD) in reactive NST is scarce, and optimal management has yet been established. We aim to evaluate whether SSD during a reactive NST at term is associated with a higher risk for fetal heart rate decelerations during labor and the need for intervention.
Methods: A retrospective, case-control study of singleton, term pregnancies at one university-affiliated medical center in 2018. Study group consisted of all pregnancies with an SSD in an otherwise reactive NST. For each case, two consecutive pregnancies without SSD were matched in a 1:2 ratio. The primary outcome was the rate of cesarean delivery (CD) due to non-reassuring fetal heart rate monitoring (NRFHRM).
Results: 84 women with a diagnosis of SSD were compared to 168 controls. SSD during antenatal fetal surveillance was not associated with the presence of fetal heart rate decelerations during labor and did not increase the rate of CD overall or for NRFHRM (17.9% vs. 13.7% and 10.7% vs. 7.7%, study vs. control group, respectively, p>0.05). Likewise, rates of assisted deliveries, maternal outcomes, and neonatal complications were similar between the groups.
Conclusions: SSD during a reactive NST in term pregnancies is not associated with an increased risk for adverse perinatal outcomes. Expectant management should be considered in pregnancies with SSD at term.
Comparison of tumour tissue homogenisation methods: mortar and pestle versus ball mill
Authors: Ostapowicz Julia , Maćkowiak Bartosz , Ostrowska Kamila , Kaczmarek Barbara , Pietras Natalia , Frąckowiak Dawid , Fundowicz Magdalena , Golusiński Wojciech , Suchorska Wiktoria
Published: January 2023

BackgroundEfficient genetic material (DNA and RNA) and protein isolation are crucial for obtaining scientifically significant results in biotechnological analytical procedures. DNA mutations, gene expression determination on transcript and protein levels and high-throughput screening are core analyses in cancer studies. The most common tissue homogenisation methods include mortar and pestle usage. This study compares the classic pulverisation method with the nonconventional use of a ball mill.MethodsThe biological material constituted cancerous and unchanged adjacent tissues collected from five patients with head and neck squamous cell carcinoma (HNSCC). Tissues were halved for trituration using both homogenisation methods. The obtained material was used for DNA, RNA, and protein isolation and further PCR, RT-qPCR, and Western-blot analysis.ResultsAfter tissue homogenisation in a ball mill, we found significantly higher DNA concentration than mortar and pestle usage but no significant differences in RNA concentration and DNA and RNA purity ratios. However, the DNA quality assessed by gel electrophoresis and PCR was more excellent in samples ground with mortar and pestle. On the contrary, we demonstrated better RNA quality in ball-milled samples and gene expression analysis using RT-qPCR. We found no significant differences between protein concentration and quality extracted from tissues homogenised with the two compared methods.ConclusionOur results demonstrated that both methods of tissue homogenisation: ball mill versus mortar and pestle, are suitable for human tissue homogenisation to use the DNA and protein in downstream analysis. The ball mill homogenisation is more suitable for RNA extraction and gene expression analysis.
Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain
Authors: Opsahl Julia , Fragoso-Bargas Nicolas , Lee Yunsung , Carlsen Ellen , Lekanova Nadezhda , Qvigstad Elisabeth , Sletner Line , Jenum Anne Karen , Lee-Ødegård Sindre , Prasad Rashmi , Birkeland Kåre , Moen Gunn-Helen , Sommer Christine
Published: January 2023

Objectives
We aimed to discover CpG sites with differential methylation in peripheral blood leukocytes associated with body mass index (BMI) in pregnancy and gestational weight gain (GWG) in women of European and South Asian ancestry. Furthermore, we aimed to investigate how the identified sites were associated with methylation quantitative trait loci, gene ontology, and cardiometabolic parameters.
Methods
In the Epigenetics in pregnancy (EPIPREG) sample we quantified maternal DNA methylation in peripheral blood leukocytes in gestational week 28 with Illumina’s MethylationEPIC BeadChip. In women with European (n = 303) and South Asian (n = 164) ethnic ancestry, we performed an epigenome-wide association study of BMI in gestational week 28 and GWG between gestational weeks 15 and 28 using a meta-analysis approach. Replication was performed in the Norwegian Mother, Father, and Child Cohort Study, the Study of Assisted Reproductive Technologies (MoBa-START) (n = 877, mainly European/Norwegian).
Results
We identified five CpG sites associated with BMI at gestational week 28 (p from 4.0 x 10− 8 to 2.1 x 10− 10). Of these, we were able to replicate three in MoBa-START; cg02786370, cg19758958 and cg10472537. Two sites are located in genes previously associated with blood pressure and BMI. Methylation at the three replicated CpG sites were associated with levels of blood pressure, lipids and glucose in EPIPREG (p from 1.2 x10− 8 to 0.04). Pathway analysis suggested involvation in inflammatory pathways (p from 1.9 x10− 8 to 4.7 x10− 5). No CpG sites were significantly associated with GWG.
Conclusions
We identified five CpG sites associated with BMI at gestational week 28, three of which were replicated in an independent cohort. Several gene variants were associated with methylation at cg02786379, suggesting a genetic component influencing differential methylation. The identified CpG sites were associated with cardiometabolic traits, as well as with inflammatory pathways.
Fragility Curve Development of Highway Bridges Using Probabilistic Evaluation (Case Study: Tehran City)
Authors: Mogheisi Meisam , Tavakoli Hamid Reza , Peyghaleh Elnaz
Published: January 2023

Seismic fragility analysis of bridges can be used to identify the probability of different damage states of bridges under earthquake hazards. This study aims to generate the fragility curve of highway bridges in Tehran, Iran, where these curves are not provided yet. To derive new fragility curves, the fragility curve of highway bridges from studies all around the world has been classified into different categories, based on their structural designs, bridge materials, country, and their analytical methods. A decision-tree analysis has been used to determine new fragility curves. The accuracy of these new curves was then assessed using a case study bridge and incremental dynamic analysis. The assessment analysis indicates that newly developed fragility curves for Tehran city have reasonable accuracy. The average difference between the derived fragility curve by the curves determined using Incremental Dynamic Analysis was acceptable. These new fragility curves helped to identify bridges throughout the Tehran city highways with higher seismic vulnerability. These can also be used for risk assessment and reducing the of seismic risk studies and future urban planning.
Intelligent Methods in Phishing Website Detection: A Systematic Literature Review
Authors: Sattari Yeganeh , Montazer GholamAli
Published: January 2023

"Phishing" is a well-known cyberattack in which Internet users are targeted and directed to a fake website, similar to a legitimate and valid one. In such attacks, users are deceived into entering their sensitive information, such as passwords and credit card details, into these fake websites, which can be subject to further abuse by attackers, such as money and identity theft. Phishing has been causing problems for end users in network security for nearly three decades. In recent years, with the expansion of the Internet, it has become one of the most significant security issues in cyberspace, which needs to be addressed. To this end, researchers have provided many approaches to detect phishing websites, among which intelligent-based solutions have attracted more attention due to their adaptability to new samples. This research investigates intelligent methods for detecting phishing websites by examining 71 selected papers using a Systematic Literature Review (SLR) approach. It starts with an overview of phishing, including history, life cycle, statistics, and causes of user entrapment. Then, it presents kinds of methods for phishing website detection, as well as the steps of implementing machine learning methods, including data collection, feature extraction and selection, model creation, and evaluation. Next, it examines intelligent approaches to detecting phishing websites and compares them with their advantages and limitations, and finally, it discusses several challenges in this field to pave the way for further work.
Late recurrence of CD44 variant 9-positive gastric carcinoma 12 years after surgery: A case report
Authors: Hayashi Hirokatsu , Yasufuku Itaru , Higashi Toshiya , Chikaishi Wakana , Yokoi Ryoma , Fukada Masahiro , Sato Yuta , Asai Ryuichi , Tajima Jesse Yu , Saigo Chiemi , Makiyama Akitaka , Tanaka Yoshihiro , Okumura Naoki , Murase Katsutoshi , Takahashi Takao , Futamura Manabu , Takeuchi Tamotsu , Matsuhashi Nobuhisa
Published: January 2023

Background

Late recurrence of gastric cancer of over 10 years post-gastrectomy is extremely rare, and the mechanism of late recurrence is unclear. We report a case of para-aortic lymph node metastasis that recurred 12 years postoperatively.

Case presentation

A 44-year-old woman who was pathologically diagnosed with moderately to poorly differentiated adenocarcinoma with T2N2M0 Stage IIIA according to the Japanese Classification of Gastric Carcinoma (the 13th Edition) underwent laparoscopic distal gastrectomy with D1 + lymph node dissection. She received adjuvant chemotherapy with tegafur-uracil (400 mg/day) for 2 years. At postoperative year (POY) 5, a swollen lymph node was detected in the No.16b1lat lymph node station. However, positron emission tomography (PET) revealed normal uptake, and tumor markers were within normal limits; hence, the possibility of metastasis was judged to be low, and the patient was placed under observation. At POY 12, computerized tomography revealed an enlargement of the No.16b1lat lymph node station, and PET revealed abnormal uptake. Endoscopic ultrasound-guided fine-needle aspiration revealed a moderately differentiated adenocarcinoma. Hence, a diagnosis of recurrence of gastric cancer was made. She underwent para-aortic nodal dissection (PAND) of No.16b1lat & int stations. Immunochemical staining was similarly consistent with recurrence of gastric cancer. Meanwhile, CD44 variant 9 (CD44v9), a cancer stem cell marker for gastric adenocarcinoma, was attenuated in the recurrent lesions compared with the primary lesions. Postoperatively, she received chemotherapy with tegafur-gimeracil-oteracil (80 mg/day) for 1 year. At POY 4 after PAND, the patient remained well with no evidence of recurrence and distant metastasis.

Conclusions

The degree of staining for CD44v9 in the recurrent lesions may be related to the timing of recurrence. Hence, it is important to continue to investigate the role of the expression of CD44v9 in gastric cancer and to clarify the details.
Risk factors for diabetic ketoacidosis in acute pancreatitis patients with type 2 diabetes
Authors: Li Lin , Li Linzhen
Published: January 2023

Background and purpose: To analyze the risk factors for diabetic ketoacidosis in acute pancreatitis patients with type 2 diabetes.
Patients and Methods: 25 patients were included in this prospective single-centre study to analyze the incidence and risk factors for diabetic ketoacidosis (DKA) in acute pancreatitis patients with type 2 diabetes.
Results:The 25 AP patients were divided into DKA group and non-DKA group according to whether they had DKA. 7(28%) patients developed DKA within 48 hours of admission.There were significant differences in sex (P < 0.001), age (P=0.014), BMI (P=0.034), number of drinkers (P=0.036), and number of smokers (P=0.023). There was significant difference in uric acid concentration (P=0.041), but no statistically significant differences in triglyceride level (P=0.389) and total cholesterol concentration (P=0.534) between the two groups. In the DKA group, all the 7 (100%) patients had poor previous blood glucose control, but in the non-DKA group, only 5(27.78%) patients had poor previous blood glucose control. The difference was statistically significant. Only 1 patient in both groups had severe pancreatitis, and the difference was statistically significant (P=0.003).
Conclusions: The incidence of DKA in AP patients with diabetes is high. Age, gender, alcohol,smoking, BMI,worse glycemic control, severe AP and uric acid concentration may be predictors of DKA in AP patients with diabetes.
Secure Waste Collection Approach for Smart Cities
Authors: LAMA RADHIKA , KARMAKAR SANDIP
Published: January 2023

The notable increase in the spread of diseases such as COVID-19 and monkeypox in the recent scenario significantly increases the need for an efficient waste collection system in the cities. The traditional approach to waste collection is time-consuming, inefficient, unreliable, and lacks real-time assessment, which has huge impacts on the health care system of the cities. The incorporation of advanced information technology has extensively benefited the waste collection system in the city, but there are still security risks or performance deficiencies.In this paper, we design a secure waste collection approach for smart cities using Physically Unclonable Function (PUF). We have shown that the introduced scheme is secure, fresh, trustworthy, and robust using the AVISPA tool and Mao and Boyd's logic. The informal security analysis shows that the introduced scheme accomplishes the security requirement for the smart waste collection environment. The extensive comparative security analysis, computational efficiency, and storage overhead illustrate that the introduced scheme achieves convincing security improvements with less computational and storage overhead compared to existing schemes. Hence, the hardness of the security characteristics of the proposed scheme proves its robustness and makes it feasible for practical implementation.
Dynamical astronomical object-relative cyclic signal inputs for discrete time modeling with calendric applications
Authors: Moore Steven D.P.
Published: January 2023

Accumulation of temporal errors occurs in continuous time modeling based on dynamical astronomical cycles; however, cyclic differences can also be advantageous. Dynamical cycles in nature, especially astronomical cycles, vary and lack uniformity. Unifying discrete time modeling with continuous time can chart these differences throughout linear time, building a reference repository. Ancient timekeeping systems are combined with modern computation and set theories, and when integrated with a signal system, cyclic fundamental temporal elements are created. Uniform scaling elements create unique and uniform cyclic and object-relative natural number units of time, each convertible to SI unit seconds. Despite countless Julian calendar-based comparison studies on timekeeping, ancient methodologies remain a mystery. This approach opens a hypothesized methodology that is testable for ancient observational calendric timekeeping systems. We present the first known pairing function to synchronize and assemble various independent object-relative observational-based astronomical cycles and their temporal elements. The model is applied to test a comparison between a previously proposed calendar model derived from Neolithic China and the Mesoamerican timekeeping divisional system. A 13-lunation calendar year built upon a 20-year cycle is introduced as the first new hypothesized astronomical cyclic pairing for Mesoamerica in nearly 500 years. Results validate a hypothesized link between Mesoamerica and ancient China. Combining mathematical and computational methodologies, our cyclic object-relative signal inputs from continuous time can yield new applications in astrometry and physics, as well as tools for archaeological research.
A novel RBBP8 (c.841G>T) germline mutation is a predisposition mutation in familial hereditary cancer syndrome
Authors: Yan Jinhua , Wu Jinzheng , Wang Yang , Di Xiaotang , Jiang Hao , Wen Doudou , Zhang Shubing
Published: January 2023

Background: Screening tumor susceptibility genes will be found powerful biomarkers for hereditary cancer monitoring, prevention and diagnosis, which providing opportunities for understanding the potential molecular mechanism and biomarker for precise treatment of hereditary cancer syndromes.
Methods: Whole blood exon sequencing and bioinformatics analysis uncovers a novel RBBP8 (c.841G>T) germline mutation in this familial hereditary cancer syndrome, and verified by sanger sequencing. Cell proliferation, clone formation, cell migration, in vivo tumorigenesis were investigated by CCK8, clone formation assays, transwell, in vivo xenograft. The protein localization and interaction were detected by immunofluorescence, nuclear and cytoplasmic protein extraction kit and Co-IP.
Results: A new heterozygous germline mutation of RBBP8 (c.841G>T) gene was associated with familial hereditary cancer syndrome. Unlike RBBP8-WT is mainly detected in the nucleus and could interact with BRCA1. Opposite, RBBP8(c.841G>T) is mainly located in the cytoplasm and lost interact with BRCA1, which may gain some new functions in the cytoplasm to promote breast cancer proliferation, in vivo tumorigenesis and migration. Meanwhile, patients with RBBP8(c.841G>T) germline mutation maybe benefit from PARP inhibitors (Olaparib) and platinum (Cisplatin).
Conclusions: A de novo RBBP8 (c.841G>T) germline mutation was identified from familial hereditary cancer syndrome. RBBP8 (c.841G>T) lost its ability to enter the nucleus and BRCA1 binding motif, which may gain some new functions to promote tumorigeneses in the cytoplasm. RBBP8 (c.841G>T) is a tumor susceptibility gene and candidate precision medicine biomarker in this familial hereditary cancer syndrome.
Gastric metastasis of renal cell carcinoma and molecular targeted therapy: a case report
Authors: Zhang Simeng , Liu Ruiqing , Zheng Longbo , Ma Zheng , Zhang Zhenqi , Wang Dongsheng S.
Published: January 2023

Renal cell carcinoma is a common tumor of the urinary system, accounting for 80%~85% of all primary renal tumors. It has a strong metastatic ability, but gastric metastasis of renal cell carcinoma is rare. A 75-year-old male patient was admitted to our hospital for laparoscopic right radical nephrectomy in 2017 due to the identification of space-occupying lesions in the right kidney on physical examination. Postoperative pathology showed right renal clear cell carcinoma (size 3.5 * 3 cm, WHO/ISUP classification, grade III). No further treatment was administered after the operation, but regular reexamination was performed. In August 2022, gastroscopyrevealed a slightly raised ulcer approximately 1.0 cm in diameter on the greater curvature of the gastric body, and biopsy material was obtained from the lesion. Combined with HE morphology, immunohistochemistry, and clinical history, gastric metastasis of renal cell carcinoma was diagnosed. Considering that the lesion was not suitable for endoscopic resection, oral sunitinibmolecular targeted drug therapy was started. To date, the patient is generally in good condition, and no new metastasis or expansion of the lesion has beenobserved on auxiliary examinations.
Economic value of mangrove ecosystem services in the coastal area of Bintan Island, Indonesia
Authors: Arkham Muhammad Nur , Riadi Septa , Wahyudin Yudi , Krisnafi Yaser
Published: January 2023

The mangrove ecosystem in Bintan Regency provides many benefits, both directly and indirectly, for the people around it. Mangrove ecosystem services also vary and play a role in adaptation and mitigation processes in the face of climate change. Oil pollution that occurs every year in Bintan Regency has a negative impact both ecologically and economically. This research aims to estimate the value of mangrove ecosystem services in the East and North Coastal Areas of Bintan Island, which can be used as a basis for the management of the Area. The data collection method used was a survey using a questionnaire on fishermen, tourists, tourism managers, and the surrounding community. In addition, it also collects some secondary data to support data analysis. The results of the study state that the estimated economic value of mangrove ecosystem services is Rp. 135,663,899,478.30/year from a mangrove area of 4,354.11 ha. The economic value consists of providing services by 61%, regulatory services by 21%, supporting services by 2%, and cultural services by 16%. This estimate can be used as a basis for policies and strategies for mangrove conservation and social welfare, as well as a consideration in making claims related to damage to the coastal and marine environment as a result of oil spills and others that often occur in the Bintan Island Area.
Attack-Defense Tree-based Security Analysis and Optimal Defense Synthesis for System Design
Authors: Meng Baoluo , Viswanathan Arjun , Saswata Saswata , William William , Moitra Abha , Siu Kit , Durling Michael
Published: January 2023

Attack-Defense Trees (ADTrees) are widely used in the security analysis of software systems. In this work, we introduce a novel approach to analyze system architecture models via ADTrees and to synthesize an optimal cost defense solution using MaxSMT. We generate an ADTree from the Architecture Analysis and Design Language (AADL) model with its possible attacks, and implemented defenses. We analyze these ADTrees to see if they satisfy their cyber-requirements. We then translate the ADTree into a set of logical formulas, that encapsulate both the logical structure of the tree, and the constraints on the cost of implementing the corresponding defenses, such that a minimization query to the MaxSMT solver returns a set of defenses that mitigate all possible attacks with minimal cost. We provide an initial evaluation of our tool on a delivery drone system model which shows promising results.
Information-Extreme Machine Learning of Wrist Prosthesis Control System Based on the Sparse Training Matrix
Authors: Suprunenko M. K. , Zborshchyk O. P. , Sokolov O.
Published: January 2023

The article considers the problem of machine learning of a wrist prosthesis control system with a non-invasive biosignal reading system. The task is solved within the framework of information-extreme intelligent data analysis technology, which is based on maximizing the system’s information productivity in machine learning. The idea of information-extreme machine learning of the control system for recognition of electromyographic biosignals, as in artificial neural networks, consists in adapting the input information description to the maximum total probability of making correct classification decisions. However, unlike neuro-like structures, the proposed method was developed within a functional approach to modeling the cognitive processes of the natural intelligence of forming and making classification decisions. As a result, the proposed method acquires the properties of adaptability to the intersection of classes in the space of recognition features and flexibility when retraining the system due to the recognition class alphabet expansion. In addition, the decision rules constructed within the framework of the geometric approach are practically invariant to the multidimensionality of the space of recognition features. The difference between the developed method and the well-known methods of information-extreme machine learning is the use of a sparse training matrix, which allows for reducing the degree of intersection of recognition classes significantly. The optimization parameter of the input information description, the training dataset, is the quantization level of electromyographic biosignals. As an optimization criterion is considered the modified Kullback information measure. The proposed machine learning algorithm results are shown in the example of recognition of six finger movements and wrist.
Isotherm Study of Crystal Violet on Activated Carbon Synthesized from Millet Stover
Authors: Salahudeen N. , Abubakar M.
Published: January 2023

Continuous release of synthetic dyes from industrial effluent into surface water poses a huge environmental threat and health hazard to humans and aquatic life. The need to right the wrong occasioned by the inimical industrial practice of uncontrolled release of carcinogenic dyes into the surface water calls for research into effective treatment technologies for the treatment of dye-contaminated industrial effluent. The isotherm of Crystal Violet (CV) solution on activated carbon (AC) synthesized from millet stover was investigated and presented herein. Samples of AC were synthesized from millet stover at 120⁰C using phosphoric acid as the activating agent. Employing varying mix ratios of stover-to-phosphoric acid (1:0, 1:1, 1:2, 1:3, and 1:4), respective samples of AC were synthesized. The batch adsorption process of the various samples of the AC in 15 mg/l initial concentration of an aqueous solution of CV was carried out at varying times. The CV’s change in the sorbate’s concentration was monitored using a UV spectrophotometer. The optimum adsorption time was 240 min. The optimally synthesized activated carbon was the 1:2 sample having an equilibrium sorbent concentration of 0.74 mg/L and sorbate uptake of 95.1%. Langmuir, Freundlich and Temkin isotherm models were employed for the isotherm analysis. The values of the Langmuir, Freundlich and Temkin models were 0.99, 0.90, and 0.94, respectively. The isotherm constants for the Langmuir, Freundlich and Temkin models were –1.52 l/mg, –4.08, and 0.005 l/min, respectively. The Langmuir isotherm model best fitted the adsorption mechanism with a maximum equilibrium adsorption capacity of 14.0 mg/g.
Current trends in the diagnosis and treatment of acute tumor lysis syndrome in children: a review
Authors: Matinyan Nune V. , Valiev T. T. , Martynov L. A. , Akimov V. P. , Kovaleva E. A. , Buidenok Yu. V.
Published: January 2023

INTRODUCTION: Acute tumor lysis syndrome (ATLS) complicates the treatment of highly aggressive leukemia, lymphomas in children and is accompanied by a fatal outcome in 21.4 % of patients. The basis of ATLS is the decay of tumor cells, in which the volume of decay products exceeds the excretory capabilities of the kidneys. The ATLS risk group includes patients with acute lymphoblastic leukemia accompanied by hyperleukocytosis (above 100×109/L) and non-Hodgkin's lymphomas with a large tumor mass (III–IV stages of the disease). To date, the volume of thematic publications in the aggregator of the PubMed medical database is not so large: over the past 10 years, there have been 12 articles, which makes the task of systematizing previously accumulated and recently received information even more relevant for the practitioner. OBJECTIVE: Generalization of the modern scientific base for the diagnosis and treatment of ATLS in children. MATERIALS AND METHODS: To highlight the modern scientific base concerning the diagnosis and treatment of ATLS in children with oncohematological diseases, a search was conducted in PubMed, Research Gate, Web of Science Core Collection and Google Scholar systems for the period from 2000 to August 2022. RESULTS: In total, 94 articles were found, including 1 systematic review with meta-analysis and 16 review articles that meet the requirements. CONCLUSIONS: Conservative ATLS prophylaxis is effective in 93.4–93.6 % of patients. However, in 8.8–21.4 % of patients, ATLS acquires a rapid character, accompanied by the lack of the ability to conservatively correct the indicators of potassium, phosphorus, uric acid. Additional study of the pathogenetic mechanisms of the complication, identification of key targets of drug therapy and a multidisciplinary approach in the treatment of an extremely prognostically unfavorable group of oncohematological patients with advanced stages of the tumor process are possible components of further improving the effectiveness of ATLS therapy.
Adherence to treatment in intensive care units on the example of pediatric sepsis: a review
Authors: Mironov Petr I. , Аleksandrovich Yu. S. , Pshenisnov K. V. , Akhmetshin R. Z. , Potapov V. S.
Published: January 2023

INTRODUCTION: Intensive care does not always require only a large amount of resources. An important aspect is the formation of a multidisciplinary team involved in the treatment of patients in critical condition. OBJECTIVE: To demonstrate the need for the staff of intensive care units to use protocols for the diagnosis and treatment of critical conditions on the example of sepsis in children. MATERIALS AND METHODS: The analysis of publications devoted to the study of the impact of the implementation of the clinical recommendations of the Surviving Sepsis Campaign for the treatment of sepsis in children on the outcomes of the disease. The articles were searched in the abstract databases PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science Core Collection and Google Scholar for the period from 2011 to July 2022. Keywords were used: “pediatric sepsis”, “implementation”, “protocolized treatment”, “adherence”. RESULTS: During the search, only thirteen observational studies were found, nine of which were presented retrospectively, which can be attributed to the design flaws of the submitted works. It was revealed that the use of the entire complex of diagnostic and therapeutic measures presented in clinical recommendations and protocols for intensive therapy of sepsis in children can significantly improve the results of treatment, but the commitment of doctors to their use in routine clinical practice remains low and does not exceed 40 %. CONCLUSIONS: The main reason for the lack of commitment to the implementation of recommendations and standards for the treatment of sepsis in children is not only in the presence of organizational obstacles, but also in the absence of reasonable algorithms for its implementation.