bluuebunny/crossref_metadata_2025 huggingface dataset:
Redefining strategies for consolidated destinations
Authors: Crespi-Vallbona Montserrat
Published: January 2024

Consolidated tourist destinations are those that have achieved a major influx of visitors and that have been particularly successful in financial terms. However, they risk sliding into stagnation and decline if they are not governed in a manner that ensures their sustainability. Therefore, urban designers and planners seek to boost a destination’s position by diversifying and enhancing its attractions, as well as the quality of the experiences offered, while also fostering local participation. This coincides with the two main goals of the Barcelona DMO (Destination Management Organization), which are to redistribute tourism flows and income throughout the city and also to seek and develop new icons and motivations for both travellers and local residents alike. In this context of a boom in both tourism supply and demand, literary tourism is being proposed as a new trend and niche that can offer new options and itineraries.
Prediction Strength of Some Risk Factors for Severe COVID-19 Course at hospital Admission in Al-Nasiriyah City -Iraq : A Cohort Retrospective Single center Study
Authors: Musa Muslim Dhahr , Mutar Abbas Dhkeel , Al-Omar Dheyaa Khalf , Mansour Almanasra Amani Mahmoud
Published: January 2024

Background: The early prediction of the clinical course of COVID-19 helps health professionals to discriminate the severe cases that need ICU admission from those with no risk of worsening outcomes. Materials & methods: This cohort retrospective study included 389 COVID-19 patients admitted to Al-Hussein Teaching Hospital during the period from March to August 2021. Demographic characteristics, clinical symptoms, and laboratory findings upon hospital admission were analyzed by univariate analysis to determine their association with the severity of COVID-19; only those variables with (P>0.05 ) were included in the multivariable logistic regression to find the strong predictors of severity in term of Odd ratios. Results: The mean age of the 389 patients was 33.6 +- 14.8; there were 231(59.4%) severe cases (admitted to ICU), and 158(40.6%) were non-severe cases (admitted to regular wards). Univariate analysis revealed that gender (male) presence of co-morbidities and all clinical symptoms and laboratory findings were associated with severe outcomes of COVID-19. However, multivariate logistic regression revealed that dyspnea [O.R 42.58 (12.22; 148.36)] and high grad fever [O.R 29.25 (5.34; 160.24)] were very strong predictors for severity, while male gender [O.R4.26 (1.95; 9.33)] and hypertension [O.R6.83 (2.4; 19.54)] were strong predictors of the severity. On the other hand, Ferritin gave an indiscernible predictive value [O.R1.003 (1.001; 1.006)]. Conclusion: Some risk factors are very helpful for clinicians to discriminate against patients who may develop severe outcomes and need ICU admission, which might help the efficient use of health resources in sensitive times.
A rare case of Colovesical fistula in a middle-aged man managed successfully by conservative management
Authors: Potdar Ojas Vijayanand , Siddiqui Mohammed Ayub Karamnabi , Shah Akash , Vaidya Kaustubh , Chaudhary Prakhar
Published: January 2024

Colovesical fistula is an improper connection between the urinary bladder and intestinal tract. Although there are many possible causes of colonovesical fistula, Chen et al. have classified them into five main classes: congenital, traumatic, tumor, inflammatory, and other. Intestinal diverticulitis accounts for 50-70% of cases in Western countries, and nearly all of them are related to colonic or bladder fistulas. Malignant tumors (20%) rank second in Western countries as the most common cause, which are situated largely in the large intestine. Other related tumours include bladder, cervical, ovarian and prostate cancers, and non-Hodgkin's lymphoma in the small intestine. The third most prevalent cause is Crohn's disease (10%), which occurs mainly in the ileum. "Other causes" include iatrogenic injury; trauma; foreign bodies in the intestinal tract; radiotherapy; chronic appendicitis
Analysis of Characteristics and Typology of Mapili Watershed West Sulawesi Province
Authors: Wahyudi Wahyudi Isnan , Wahyudi Wahyudi Isnan , Hasnawir Hasnawir Hasnawir
Published: January 2024

The multisectoral, multidisciplinary, multi-stakeholder and multidimensional watersheds problems are the consequences of multifunctional watersheds.  The complexity of these problems demanding a system and management approach that appropriate with the characteristics and typology of the watershed. This study aims to analyze the characteristics and typology of Mapili watershed West Sulawesi Province. This research was conducted using surveys, primary, and secondary data collection. Application of geographic information system (GIS) with overlay maps and scoring was used. The results showed that Mapili biogeophysical characterization includes meteorology, morphology, morphometry, hydrology, watershed capability and socioeconomic, cultural and institutional characterization will influence the system of Mapili watershed management. Mapili watershed can be classified into two typology watershed, namely: typology II, which has a low total population density (97 people/km2) with high rainfall (>2500 mm/yr); and typology IV, which has a high total population density (377 people/km2) with low rainfall (<1500 mm/yr). Both typologies have different characteristics of watershed problems. Typology II is generally located in the central area and upstream Mapili and Typology IV are located in the downstream areas of Mapili watershed.
Preventive Maintenance Practices on School Facilities: Implications for Effective Instructional Delivery in Technical Education Programmes in Colleges of Education in South- East Nigeria
Authors: Ibeneme O.T. , Izundu Lilian
Published: January 2024

The study examined the implications of preventive maintenance practices on school facilities for effective instructional delivery in technical education programmes in Colleges of Education in South-East Nigeria. One research question guided the study and two null hypothesis was tested at 0.05 alpha level. It adopted survey research design. The population of the study comprised 204 lecturers in college of education in South-East of Nigeria. The entire population was used for the study since it was not too large and was manageable. Hence, the study did not adopt any sampling technique. A 21– item structured questionnaire was used as instrument for data collection for the study. Three experts validated the instrument. Cronbach’s Alpha method was used to establish the reliability of the instrument in a pilot test; which yielded a reliability coefficient of 0.72. The instrument for data collection was sent to respondents through research assistants. Data related to the research questions were analyzed using mean and standard deviation. The t-test statistics was used to test the hypothesis at 0.05 level of significance. Findings from the study revealed that preventive maintenance practices on school facilities to small extent influence instructional delivery in technical education programmes in Colleges of Education in South-East Nigeria. The study recommended among others that, government through the Ministry of Education and Provosts of Colleges of Education should provide funds and materials needed for preventive maintenance of school facilities.
Spatial Diversity Mapping of Plant Species in Karlahi Forest Reserve, Fufore Local Government Area of Adamawa State
Authors: Jerry Samuel Hyellamada
Published: January 2024

The analysis of the spatial species diversity in Karlahi Forest Reserve of Fufore Local Government of Adamawa State, Nigeria was carried out and it was aimed at analyzing the distribution of tree species within the forest reserve which is vital to the understanding of changes that occurred within the forest. This research adopted three methodological approaches that are, the use of Geographic Information System (GIS) and field investigation to determine the species diversity. The results of the species diversity show that zone 3 has the highest species richness with Bauhinia thonningii and Anogeissus Leiocarpus also known as “Kalgoo” and “Mark” in Hausa language respectively as dominant species and species endemism, zone 4 has the highest species red list followed by zone 3 and 2. The common species that make the red list are Pterocarpus Erinaceus, ziziphus spina-christi, Balanites Aegyptiaca, Vitellaria paradoxa, Anogeissus Leiocarpus, banhinia thonningii, Parkia Biglobosa, Detarium microcarpum. It is recommended that Land Cover information and regular species diversity audit should be incorporated into the conservation practices and Nation and state policies on Forest reserves and parks should be adhered to strictly.
Atraumatic Unilateral Myositis with Rhabdomyolysis of the Right Lower Extremity
Authors: Cho Michael , Dluzneski Alex , Elbadri Samyr , Huang Derrick
Published: January 2024

This clinical image article depicts unilateral myositis with rhabdomyolysis of the right lower extremity.
Lombok Halal Tourism Destination (LOMUTION): A Strategy to Increase the Stability of Augmented Reality-Based Lombok Tourism in Realizing Indonesia's Halal Industry Center
Authors: Kencana Dahlia Eka Syahputri
Published: January 2024

The existence of halal tourism in Lombok is a destination that is sought after by many local and foreign tourists. The Ministry of Tourism (2019) noted that in 2015, Lombok received 2 awards from the World Halal Tourism Award (WHTA) in Abu Dhabi in the categories of World Best Halal Destination and World Best Halal Honeymoon. In the midst of the onslaught of technology, various strategic steps can be used to welcome the halal tourism sector, especially after the Covid-19 pandemic, one of which is utilizing Augmented Reality (AR). The results also showed the effectiveness of AR as a tourism promotion medium with 94% of visitors feeling facilitated, 97% stating AR systems are more communicative, and 95% saying they are interested in visiting tourism after using AR. Lomution is a strategy in improving the halal tourism industry in Lombok through the establishment of a platform that bridges tourists to visit tourist attractions. This research is a Research and Development (R&D) development research that aims to produce products and test product effectiveness. The type of research approach used is observational research and literature study. The stages of development research can be summarized into four stages, the 4D (define, design, development, and dissemination), so as to produce a discovery that will be used as a solution. Lomution, becomes one of the tourism digitalization platforms through the integration of Augmented Reality (AR) that supports the creation of Sustainable Smart Tourism. In its realization, Lomution was developed in a mobile platform because it is more flexible, accessible through various devices and faster to the present. With the development of the Lomution application, it makes it easier for tourists to access and visit halal tourist destinations in Lombok and become an innovation in accordance with the digital era to increase the potential for sustainable halal tourism.
File Storage System Using Hybrid Cryptography
Authors: Raj Prathik
Published: January 2024

Data stored in the cloud is increasingly gaining popularity for all users including personal, institutions and business purposes. The data is usually highly protected, encrypted and replicated depending on the security and scalability needs. Despite the advances in technology, the practical usefulness and longevity of cloud storage is limited in today’s systems. This project provides a solution to the problem of securely storing the client’s data by maintaining the confidentiality and integrity of the data within the cloud. This project addresses the problem of ensuring data confidentiality against cloud and against accesses beyond authorized rights. To resolve these issues, we designed a data encryption model that is in charge of storing data in an encrypted format in the cloud. To improve the efficiency of the designed architecture, the service in form of the model designed allows the users to choose the level of security of the data and according to this level different encryption algorithms are used. Data transmitted through internet is getting larger every day. Therefore an algorithm is required by which our data can be transferred speedily and securely. The main aim of this particular research is to protect the transmitted data with the help of encryption and decryption techniques.
A Generalization of the von Bertalanffy growth Model using the BSDE Approach
Authors: Chikvinidze B. , Mania M.
Published: January 2024

The generalized von Bertalanffy growth model with random extremal length is expressed as a unique solution of a Backward Stochastic Differential Equation.
Niveles de conciencia y estilos parentales ante el acceso y consumo de pornografía en la infancia y adolescencia
Authors: Ballester Brage Lluís , Sedano Colom Sandra , Lorente-De-Sanz Judith , Aznar-Martínez Berta
Published: January 2024

La nueva pornografía distribuida en Internet representa un reto considerable para las familias. El estudio de la percepción sobre el acceso, consumo para sus hijos e hijas, así como los niveles de conciencia sobre las consecuencias, es una cuestión esencial para la mejora de los procesos de socialización. Junto a estos aspectos, también se plantea el tema clave de cómo están afrontando estas cuestiones desde la perspectiva de la dinámica familiar, es decir, con qué estilos parentales se relacionan padres y madres con sus hijos e hijas.
Para conocer estas cuestiones se ha realizado una encuesta en las Islas Baleares en el segundo semestre de 2022, obteniendo una participación muy elevada, contándose finalmente con una muestra de 2592 familias. Una de las limitaciones con la que nos hemos encontrado ha sido la desigual participación de padres y madres, siendo estas últimas las que han participado de manera mayoritaria.
Los resultados muestran que el nivel de consciencia del acceso y consumo de pornografía de sus hijos e hijas es bastante reducido, aunque la conciencia sobre las consecuencias y el reconocimiento de la necesidad de la educación de las emociones, los afectos y la sexualidad, para niños, niñas y adolescentes, así como para las propias familias, son muy elevadas.
El estudio representa el primer análisis sociológico con una muestra representativa de familias y aporta orientaciones sobre la situación actual de las dinámicas familiares en relación con los procesos de socialización mediados por la pornografía.
Training of Political Skills as Moderator between Cultural Intelligence and Expatriate Adjustment: A Social Learning Theory Perspective
Authors: Shamim Fatima , Qazi Shadab , Khalid Yasra , Chughtai Muhammad Salman
Published: January 2024

Background - Applying social learning theory, we propose a relationship of cultural intelligence with the moderation effect of political skills to predict expatriate adjustment. Design/methodology/approach - Three ninety-one participants voluntarily participated in the survey for the data collection from four sectors (banking, telecom, software, and public). Findings - The findings reveal that a direct positive influence of cultural intelligence on expatriate adjustment and political skills positively moderates this relationship.Practical Implications- This study provides guidance to policymakers and practitioners that by using the tools of cultural intelligence and political skills, they can overcome the hurdles faced by the expatriates for adjustment in multi-national firms and culture.Originality/value - This study emphasized the primary domain of political skills, which enables the expatriates to adjust themselves with higher cultural intelligence in the environment of multinational firms.
Change-Oriented Leadership and Frugal Innovations: A Moderated Mediation Model of Readiness to Change and Learning Goal Orientation
Authors: Chughtai Muhammad Salman , Shaheera Amin  , Yasra Khalid  , Safa Ilyas Ahmed
Published: January 2024

Purpose - Whether or not organizations can produce fugal innovations depends on the people involved in the innovation process. This paper aims to investigate whether leaders could influence their subordinates' change readiness by employing a leadership style called “change-oriented leadership” and what role is played by the learning goal orientation of individuals for frugal innovations.
Study Design/Methodology/Approach - The researchers of this study use the temporal separation method, and data was collected in two phases at one-month intervals with a sample of 313 permanent employees working in the pharmaceutical and textile sectors.
Findings - The researchers of this study found that change-oriented leaders significantly increase frugal innovations. This effect is mediated by employees' self-reported change readiness and moderated by their learning goal orientation. Our results demonstrate that leaders substantially influence the degree of change readiness for organizations to develop frugal innovations. Our study also highlights that if people have a learning goal orientation, their change readiness is not fixed but can be altered by their social environment, especially by organizational leaders.
Research Limitations- Developing economies are facing the challenges of higher costs which stress that how organizations can reduce it, and the idea of frugal innovation is one of them. For that purpose, from the organizational point of view, there is a need for a learning environment that provides a platform for individual and team learning and critical thinking which may lead to better implementation of frugal innovation. Further, from the individual level perspective self-efficacy (creative, change, and occupational) may help the employees to take initiative for the achievement of organizational goals (i.e., frugal innovation).
Implications-This study has implications for current theories about frugal innovations, which view people’s lack of change readiness as a significant impediment. Also, these implications have for current theories about change-oriented leadership, which we expand to the societally important realm of frugal innovations.
Originality/Novelty- Our findings guide organizations and policymakers who want to enable frugal innovations to ensure the competitiveness of their organizations and the growth of economies, especially in developing countries.
The Effects of Readiness to Change on Workers Performance and Management knowledge During Covid-19
Authors: Arshad Faria , Zara Sabeen
Published: January 2024

Businesses are finding it increasingly difficult to avoid being swept up in the Fourth Industrial Revolution (fourth industrial revolution). Any company expecting to be successful in the future must develop a plan that is both unique and inventive. This technique might help both established and new firms equally, allowing them to escape today's climate's harmful effects while allowing them to grow in the future. A company's operational actions must be tracked using an integrated mapping system. For global businesses, it is vital to underline the importance of preparing the organization for adjustments in its strategic plans. Everyone who works in manufacturing must be prepared to deal with an ever-changing environment due to global competitiveness. Directly involved personnel have a more positive attitude on change and hence are more likely to contribute to the company's success. "Performance" refers to a person's prowess in completing a task. Continuous improvement is the ultimate goal of this management style, which individuals share, teams, and the entire company. Its main objective is to boost production. Data collected was primary. This was a quantitative study and the elected approach to measure each variable was through the survey; every variable of this study was measured using questionnaires that were adjusted from authentic sources and data was gathered through internet-based means. The information was gathered from employees living in Pakistan. Data was collected from 250 individuals, and we came to find out that readiness to change has a significant and positive impact on management knowledge and employee performance.
Nexus between Fiscal Deficit and Economic Growth: An Empirical Evidence of Pakistan
Authors: Usman Abid , Zaib Amir , Khan Ikram Ullah Khan , Wazir Kashmala Wazir
Published: January 2024

The study's main objective is to analyze the nexus between fiscal deficit and economic growth. A comprehensive review of the literature has been reviewed to address this objective, which presented different other intertwined factors resulting impact due to fiscal deficit, thereby economic growth. Data regarding all the variables such as GDP Growth (GDP), Fiscal Deficit (FD), Public Investment (PI), Inflation Rate (INF), Exchange Rates (EXR), and Debt to GDP Ratio (GDP) has been collected from different secondary sources such as World Bank (WB), State Bank of Pakistan (SBP) and Ministry of Pakistan (MOP) for the period between 1979 and 2019 for Pakistan. Due to the time-series nature of the dataset, the trend in the data was initially assessed. After confirming the trend, the unit root test has been performed to test the stationarity in the dataset. The results revealed a unit root in the dataset at a level for each variable. A cointegration test has been performed to check if there are any cointegrating equations for the data. The results revealed the presence of two (2) cointegrating equations in the dataset. Because of the cointegrating vectors, a vector error correction model has been performed to normalize the effect of cointegrating equations. Additionally, the VECM provided both the short-run and long-run effects of the variables. Both the long and short VECM model run outcomes revealed that the fiscal deficit, public investment, and inflation rate have a strong negative impact on economic growth while exchange rate and debt to GDP ratio have a strong positive impact on economic growth in the long run.
The Impact of Bank Internal and External Factors on the Commercial Bank’s Liquidity: Empirical Evidence from Pakistan
Authors: Rasheed Junaid , Abbas Zaheer
Published: January 2024

The purpose of this research is to identify internal and external factors affecting the liquidity of Pakistani banks. Bank balance sheets and income statements were used to calculate study variables. With panel data, the random effect method was used to analyze data from ten domestic and international commercial banks active in Pakistan from 2011 to 2020. This study has analyzed liquidity, which has been measured by two liquidity ratios cash and marketable securities to total assets liquidity 1 and loans to deposits liquidity 2. In the study, internal factors include bank size, return on assets, and cost of funds, capital adequacy, and non-performing loans. The external factors are GDP and inflation. In this study, bank size increased liquidity 1 and decreased liquidity 2, but both were significant. The return on assets liquidity 1 has increased significantly, but the return on assets liquidity 2 has increased insignificantly. The cost of funds has increased liquidity 1 and decreased liquidity 2 but has an insignificant effect on liquidity. The capital adequacy ratio has decreased significantly and insignificantly effect on both liquidities. Non-performing loans have increased liquidity 1 significantly and decreased liquidity 2 insignificantly. GDP has increased liquidity 1 significantly and decreased liquidity 2 insignificantly. Inflation has increased liquidity 1 significantly and decreased liquidity 2 insignificantly.
Anthocyanins: Plant-based flavonoid pigments with diverse biological activities
Authors: Patra Sandip , Makhal Priyanka N. , Jaryal Shubham , More Nilesh , Kaki Venkata Rao
Published: January 2024

Anthocyanins are flavonoid containing polyphenolic phytochemicals. They are widely present in plants and accounts for different color shades displayed by the plant organs. A broad range of health-revitalizing effects is attributed to anthocyanins, constituting a vital part of the human diet. They are also accountable for ameliorating the detrimental effects of various lifestyle diseases, including cancer, cardiovascular disorders, neurological disorders, etc. These beneficial impacts highly depend on the bioavailability of anthocyanins, governed by their absorption and metabolism in the human body. The primary goal of this review is to summarize the latest anthocyanin knowledge while focusing on the chemistry, pharmacokinetics, and various biological advantages with anti-cancer, neuroprotective, antidiabetic, antioxidant, cardiovascular protective, vision improvement, antiviral, and antimicrobial effects.
Chemical composition and cholinesterase, tyrosinase, alpha-amylase and alpha-glucosidase inhibitory activity of the essential oil of Salvia tomentosa
Authors: Kocer Mustafa , Istıfli Erman Salih
Published: January 2024

The aim of this study was to determine the chemical composition of Salvia tomentosa (Miller) essential oil and to examine its inhibitory effect on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase and α-glucosidase in vitro. In this study, the interaction between the main components of essential oil and the enzymes in question was analyzed through molecular docking analyses. The presence of 60 compounds representing 98.2% of the essential oil was determined. The major compounds of the oil were camphor (9.35%), γ-muurolene (8.37%), α-pinene (7.59%), α-caryophyllene (6.25%), viridiflorol (5.13), δ-cadinene (5.01%), and terpinene-4-ol (5.01 %). The oil exhibited higher inhibitory activity on BChE than on AChE. The BChE inhibitory activity of the oil was determined to be 16.48 mg GALAEs/g. The oil showed 47.13 mg KAEs/g inhibitory activity on tyrosinase. The inhibitory activities of the essential oil on α-glucosidase and α-amylase were determined as 703.29 and 694.75 mg ACEs/g, respectively. Based on docking binding energies, δ-cadinene, viridiflorol, γ-muurolene and α-caryophyllene were determined to be the most promising ligands showing the highest affinity (min. -6.90 kcal/mol; max. -8.40 kcal/mol) against α-amylase, AChE and BChE. However, all four ligands were found to exhibit low affinity (min. -5.50 kcal/mol; max. -5.90 kcal/mol) against tyrosinase. Considering in silico physicochemical properties, drug-like features (Lipinski's rule of 5) and intracellular targets, δ-cadinene, viridiflorol, γ-muurolene and α-caryophyllene possess hit features and do not show non-specific enzyme or protein affinity. Ligand binding assays (LBA) to be performed between the monoterpenes and enzymes in question may constitute the next step in confirming their competitive inhibitory capacity.
Selected aspects of generating short-term electricity demand forecasts, taking into account renewable energy sources
Authors: Machał Paweł , Remiorz Leszek , Bukowiec Dariusz
Published: January 2024

The risk of a decline in the quality of electricity demand forecasts in the short term increases due to the increase in the installed capacity of renewable energy sources (RES). This is mainly due to the high daily variability of electricity production from renewable sources, which is strongly dependent on local weather conditions. Production from renewable energy sources is a very complex time series, additionally reinforced by a significant increase in its share in total production. This applies in particular to photovoltaic sources in low-voltage networks. There is therefore an urgent need to improve the quality of forecasts in this area. The main goal of the research was to verify statistical models that often achieve good results in the complex problem of forecasting electricity demand. The main objective, regarding daily forecasts of consumers' demand for electricity, was achieved through the implementation of intermediate objectives, including the development of a methodology for estimating electricity generated by photovoltaic installations.
Formación profesional contextualizada en Economía para Directivos Empresariales
Authors: Cruz Montero Juan José , De la Rúa Batistapau Manuel de Jesus
Published: January 2024

En las condiciones económicas pos COVID-19, es necesario contribuir a la reflexión sobre el papel de los directivos en la gestión económica-financiera para el logro de la eficiencia empresarial, así como sobre el papel que juega la capacitación de los directivos en estas materias. En este artículo se persigue como objetivo: presentar una propuesta, científicamente fundamentada, para la estructuración curricular de la capacitación en economía de los directivos, atemperada a las condiciones del modelo Económico y Social y aplicada en el sector azucarero cubano. De forma general se utilizaron los métodos de enfoque en sistema, el histórico lógico, las encuestas y la entrevista con directivos y docentes involucrados directamente en la preparación económica y se ratificó la necesidad de que la capacitación económica a directivos debe ser reajustada a la nueva normalidad y a su impacto.  Como resultados se presenta una síntesis del diagnóstico que demuestra la necesidad de la propuesta, la conceptualización de tres términos operacionales imprescindibles y la propuesta de estructuración curricular para la capacitación en economía de los directivos que se caracteriza por ser flexible, contextualizada y sistémica. Su validación teórica se realizó mediante el criterio de expertos y en la práctica se valida mediante la prospección de escenarios, ambas demuestran su factibilidad. La conclusión final más importante es que una estructuración curricular de la capacitación de directivos; sistémica, flexible, contextualizada, estructurada por niveles y que utiliza rutas de capacitación, reúne las condiciones para satisfacer las exigencias del modelo económico y social nacional.
PRAH-PRAHAN SEBAGAI SALAH SATU TRADISI MASYARAKAT MARGAGIRI YANG MASIH DI LESTARIKAN HINGGA SAAT INI
Authors: Ramadani Vina Laela , Adilah Faris
Published: January 2024

ABSTRACK
Prah-prahan is one of the community traditions that is still preserved today. This tradition is very unique and can attract the attention of newcomers. Not only that, the purpose of holding this tradition is to commemorate the Islamic New Year because it is held on the 1st of Muharram and to ward off disease or what people usually call “repel evil”. The enthusiasm of the residents in carrying out this tradition is a form of maintaining the customs that have existed since the time of their ancestors. Participation in implementing this tradition is a form of community service to continue preserving culture. One of the KKN activity programs in Margagiri Village for 40 days includes participating in community cultural activities as a form of socialization and community service.
PENANAMAN BIBIT SAYUR SEBAGAI UPAYA PENCEGAHAN STUNTING DI KAMPUNG GEGERANG, KECAMATAN JAGONG JEGET, KABUPATEN ACEH TENGAH
Authors: Pratama Muhammad Aji , Aulia M.Reza , Nurkahiran Nurkahiran , Agustiawan Agustiawan , Afriana Nurhayati , Jaya Jaya , Saragih Tiana
Published: January 2024

Kampung Gegarang merupakan salah atu kampung di Kecamatan Jagong  Jeget, Kabupaten Aceh Tengah. Data stunting yang kami dapatkan menggunakan metode observasi lapangan, wawancara, sosialisasi.Upaya kami dalam menanggapi masalah stunting di Kampung Gegarang dengan cara melakukan penanaman bibit sayuran sebagai upaya pencegahan stunting di Kampung Gegarang
Polish-Romanian Joint Research Projects with a Focus on Internal Peripheries in Poland and Romania – Role of Endogenous and Exogenous Factors in Their Development Processes
Authors: Mitrică Bianca , Grigorescu Ines , Persu Mihaela , Damian Nicoleta
Published: January 2024

Scientific collaboration between Polish and Romanian geographers is based on a very good and long tradition. It was long developed between human and physical geographers alike. The common bilateral projects had in view aspects related to the impact of natural and human process on the planning of mountain and hilly areas, the social-economic transformations in the Romanian and Polish suburban zones, the regional development in Central and Eastern Europe, the socio-economic development of rural areas in Poland and Romania. The last bilateral project on Internal peripheries in Polish and Romanian regions – role of endogenous and exogenous factors in their development processes, coordinated by Prof. Konrad Czapiewski from the Polish side, had as main research findings identifying common solutions serving the practical problems connected with the economic and social development of the internal peripheries in both countries.
Quelles conaissances orthographiques enseignées par sept enseignantes du deuxième cycle du primaire ?
Authors: Villeneuve-Lapointe Myriam , Moreau André C. , Blain Sylvie
Published: January 2024

French spelling is based on several skills that need to be acquired: phonological, morphological and visuoorthographic. To promote this learning, formal teaching is essential to ensure academic success. However, few research has focused on orthographic knowledge taught in the classroom. In this article, the knowledge reported and taught by seven upper primary school teachers was documented. A semi-structured interview, two observations during spelling teaching and two self-confrontation interviews were used to identify the knowledge taught. According to our results, the teachers taught all spelling knowledge, even though they make few references to this knowledge in the interviews and self-confrontation interviews.
Clipping of a persistent middle cerebral artery aneurysm after previous flow diverter placement: An illustrative case and review of the literature
Authors: Veken Jorn Van Der , Keukeleire Katrien De
Published: January 2024

Flow diverter (FD) is increasingly used in the management of wide necked cerebral aneurysms. Despite a reported lower efficacy in middle cerebral artery (MCA) aneurysms, they are still being utilised. Microsurgery is best considered as an index treatment, but can also be a safe and effective treatment when encountering a persistent MCA aneurysm after prior FD. As there is a paucity in literature and more cases of failed FD are expected to appear, we want to add our experience to the existing literature. The microsurgical management of a persistent MCA bifurcation aneurysm, 3 years after a p48 MW HPC Flow Diverter (phenox GmbH, Bochum Germany) insertion is reported and the relevant literature discussed.
3D Spatial Analysis of Temporal Maintenance for Multi-use High-rise Buildings: Case Study
Authors: Mehmood Usman , Salleh Syahiirah , Ujang Uznir , Azri Suhaibah , Choon Tan Liat
Published: January 2024

Urbanization has sparked an increase in the construction of multi-use highrise buildings which consists of commercial parcels on their lower floors and residential parcels on their higher floors. In contrast to conventional landed houses, the residents of high-rise buildings share common facilities and private parcels or spaces also differ according to ownership or use. The management and maintenance of these spaces are dependent on the ownership of the parcel where each ownership adheres to different rights, restrictions, and responsibilities (RRRs). Therefore, accurate representation and identification of those parcels affected by maintenance or renovation is crucial for assisting management bodies to improve the quality of life within a multi-use high-rise building. This study attempts to implement a temporal maintenance management for highrise building parcels within a 3D spatial database. A 3D space segmentation was done to analyze the ownership and use of space in a high-rise building. Spatial queries were also performed based on the temporal maintenance of the parcels; in addition, 3D spatial relationships were used to determine adjacent parcels that were affected by the maintenance. Thus, the implementation of temporal strata database management with an accurate 3D representation of the space can provide management bodies with concise and comprehensive information on parcels with respect to ownerships and uses.
A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis
Authors: Pöhl Sebastian , Osorio-Valeriano Manuel , Cserti Emöke , Harberding Jannik , Hernandez-Tamayo Rogelio , Biboy Jacob , Sobetzko Patrick , Vollmer Waldemar , Graumann Peter L , Thanbichler Martin
Published: January 2024

Bactofilins have emerged as a widespread family of cytoskeletal proteins with important roles in bacterial morphogenesis, but their precise mode of action is still incompletely understood. In this study, we identify the bactofilin cytoskeleton as a key regulator of cell growth in the stalked budding alphaproteobacterium Hyphomonas neptunium. We show that, in this species, bactofilin polymers localize dynamically to the stalk base and the bud neck, with their absence leading to unconstrained growth of the stalk and bud compartments, indicating a central role in the spatial regulation of cell wall biosynthesis. Database searches reveal that bactofilin genes are often clustered with genes for cell wall hydrolases of the M23 peptidase family, suggesting a functional connection between these two types of proteins. In support of this notion, we find that the H. neptunium M23 peptidase homolog LmdC interacts directly with bactofilin in vitro and is required for proper cell shape in vivo. Complementary studies in the spiral-shaped alphaproteobacterium Rhodospirillum rubrum again reveal a close association of its bactofilin and LmdC homologs, which co-localize at the inner curve of the cell, modulating the degree of cell curvature. Collectively, these findings demonstrate that bactofilins and M23 peptidases form a conserved functional module that promotes local changes in the mode of cell wall biosynthesis, thereby driving cell shape determination in morphologically complex bacteria.
Detection of new pioneer transcription factors as cell-type-specific nucleosome binders
Authors: Peng Yunhui , Song Wei , Teif Vladimir B , Ovcharenko Ivan , Landsman David , Panchenko Anna R
Published: January 2024

Wrapping of DNA into nucleosomes restricts accessibility to DNA and may affect the recognition of binding motifs by transcription factors. A certain class of transcription factors, the pioneer transcription factors, can specifically recognize their DNA binding sites on nucleosomes, initiate local chromatin opening, and facilitate the binding of co-factors in a cell-type-specific manner. For the majority of human pioneer transcription factors, the locations of their binding sites, mechanisms of binding, and regulation remain unknown. We have developed a computational method to predict the cell-type-specific ability of transcription factors to bind nucleosomes by integrating ChIP-seq, MNase-seq, and DNase-seq data with details of nucleosome structure. We have demonstrated the ability of our approach in discriminating pioneer from canonical transcription factors and predicted new potential pioneer transcription factors in H1, K562, HepG2, and HeLa-S3 cell lines. Last, we systematically analyzed the interaction modes between various pioneer transcription factors and detected several clusters of distinctive binding sites on nucleosomal DNA.
What fraction of cellular DNA turnover becomes cfDNA?
Authors: Sender Ron , Noor Elad , Milo Ron , Dor Yuval
Published: January 2024

Cell-free DNA (cfDNA) tests use small amounts of DNA in the bloodstream as biomarkers. While it is thought that cfDNA is largely released by dying cells, the proportion of dying cells’ DNA that reaches the bloodstream is unknown. Here, we integrate estimates of cellular turnover rates to calculate the expected amount of cfDNA. By comparing this to the actual amount of cell type-specific cfDNA, we estimate the proportion of DNA reaching plasma as cfDNA. We demonstrate that <10% of the DNA from dying cells is detectable in plasma, and the ratios of measured to expected cfDNA levels vary a thousand-fold among cell types, often reaching well below 0.1%. The analysis suggests that local clearance, presumably via phagocytosis, takes up most of the dying cells’ DNA. Insights into the underlying mechanism may help to understand the physiological significance of cfDNA and improve the sensitivity of liquid biopsies.
Tumor Purity-Related Genes for Predicting the Prognosis and Drug Sensitivity of DLBCL Patients
Authors: Ye Zhenbang , Huang Ning , Fu Yongliang , Tian Rongle , Huang Wenting
Published: January 2024

Diffuse large B-cell lymphoma (DLBCL) is the predominant type of malignant B-cell lymphoma. Although various treatments have been developed, the limited efficacy calls for more and further exploration of its characteristics.Datasets from Gene Expression Omnibus (GEO) database were used for identifying the tumor purity of DLBCL. Survival analysis was employed for analyzing the prognosis of DLBCL patients. Immunohistochemistry was conducted to detect the important factor that influenced the prognosis. Drug sensitive prediction was performed to evaluate the value of the constructed model.VCAN, CD3G and C1QB were identified as three key genes that impacted the outcome of DLBCL patients both in GEO datasets and samples from our center. Among them, VCAN and CD3G+ T cells were correlated with favorable prognosis, and C1QB was correlated with worse prognosis. The ratio of CD68+ macrophages and CD8+ T cells was associated with better prognosis. In addition, CD3G+ T cells ratio was significantly correlated with CD68+ macrophages, CD4+ T cells and CD8+ T cells ratio, indicating it could play an important role in the anti-tumor immunity in DLBCL. The riskScore model constructed based on the RNASeq data of VCAN, C1QB and CD3G work well in predicting the prognosis and drug sensitivity.VCAN, CD3G and C1QB were three key genes that influenced the tumor purity of DLBCL, and could also exert certain impact on drug sensitivity and prognosis of DLBCL patients.
Machine learning based framework for fine-grained word segmentation and enhanced text normalization for low resourced language
Authors: Nazir Shahzad , Asif Muhammad , Rehman Mariam , Ahmad Shahbaz
Published: January 2024

In text applications, pre-processing is deemed as a significant parameter to enhance the outcomes of natural language processing (NLP) chores. Text normalization and tokenization are two pivotal procedures of text pre-processing that cannot be overstated. Text normalization refers to transforming raw text into scriptural standardized text, while word tokenization splits the text into tokens or words. Well defined normalization and tokenization approaches exist for most spoken languages in world. However, the world’s 10th most widely spoken language has been overlooked by the research community. This research presents improved text normalization and tokenization techniques for the Urdu language. For Urdu text normalization, multiple regular expressions and rules are proposed, including removing diuretics, normalizing single characters, separating digits, etc. While for word tokenization, core features are defined and extracted against each character of text. Machine learning model is considered with specified handcrafted rules to predict the space and to tokenize the text. This experiment is performed, while creating the largest human-annotated dataset composed in Urdu script covering five different domains. The results have been evaluated using precision, recall, F-measure, and accuracy. Further, the results are compared with state-of-the-art. The normalization approach produced 20% and tokenization approach achieved 6% improvement.
LSTMDD: an optimized LSTM-based drift detector for concept drift in dynamic cloud computing
Authors: Mehmood Tajwar , Latif Seemab , Jamail Nor Shahida Mohd , Malik Asad , Latif Rabia
Published: January 2024

This study aims to investigate the problem of concept drift in cloud computing and emphasizes the importance of early detection for enabling optimum resource utilization and offering an effective solution. The analysis includes synthetic and real-world cloud datasets, stressing the need for appropriate drift detectors tailored to the cloud domain. A modified version of Long Short-Term Memory (LSTM) called the LSTM Drift Detector (LSTMDD) is proposed and compared with other top drift detection techniques using prediction error as the primary evaluation metric. LSTMDD is optimized to improve performance in detecting anomalies in non-Gaussian distributed cloud environments. The experiments show that LSTMDD outperforms other methods for gradual and sudden drift in the cloud domain. The findings suggest that machine learning techniques such as LSTMDD could be a promising approach to addressing the problem of concept drift in cloud computing, leading to more efficient resource allocation and improved performance.
Transfer learning-based English translation text classification in a multimedia network environment
Authors: Zheng Danyang
Published: January 2024

In recent years, with the rapid development of the Internet and multimedia technology, English translation text classification has played an important role in various industries. However, English translation remains a complex and difficult problem. Seeking an efficient and accurate English translation method has become an urgent problem to be solved. The study first elucidated the possibility of the development of transfer learning technology in multimedia environments, which was recognized. Then, previous research on this issue, as well as the Bidirectional Encoder Representations from Transformers (BERT) model, the attention mechanism and bidirectional long short-term memory (Att-BILSTM) model, and the transfer learning based cross domain model (TLCM) and their theoretical foundations, were comprehensively explained. Through the application of transfer learning in multimedia network technology, we deconstructed and integrated these methods. A new text classification technology fusion model, the BATCL transfer learning model, has been established. We analyzed its requirements and label classification methods, proposed a data preprocessing method, and completed experiments to analyze different influencing factors. The research results indicate that the classification system obtained from the study has a similar trend to the BERT model at the macro level, and the classification method proposed in this study can surpass the BERT model by up to 28%. The classification accuracy of the Att-BILSTM model improves over time, but it does not exceed the classification accuracy of the method proposed in this study. This study not only helps to improve the accuracy of English translation, but also enhances the efficiency of machine learning algorithms, providing a new approach for solving English translation problems.