bluuebunny/crossref_metadata_2025 huggingface dataset:
is it cancer or is it autoimmune polyglandular syndrome type 2? the diagnosis during the investigation of consumptive syndrome
Authors: Ferreira Emanuelle Leonel , Gama Mirnalucci P. R.
Published: February 2025

A Síndrome Poliglandular Autoimune tipo 2 (SPA-2) é uma condição complexa
que pode incluir insuficiência adrenal autoimune, diabetes mellitus tipo 1 e
doenças da tireoide, entre outras manifestações endocrinológicas e não endocrinológicas.
A perda de peso em pacientes com SPA-2 é multifatorial e a
avaliação clínica e laboratorial detalhada é essencial para distinguir entre etiologias
de perda ponderal e garantir um diagnóstico preciso e tratamento adequado.
Esse caso clínico visa detalhar a jornada investigativa em uma paciente
com SPA tipo 2.
Keywords (deCS): Autoimmune Polyendocrinopathies; Adrenal insufficiency;
A ATUAÇÃO DO PODER CONSTITUINTE DERIVADO REFORMADOR DURANTE A PANDEMIA DA COVID-19: A APROVAÇÃO DAS PECs Nº 10/2020 E Nº 16/2020 EXTRAPOLA UMA LIMITAÇÃO CIRCUNSTANCIAL?
Authors: Costa Bruno Villela de Medeiros , Veloso Gabriella Diniz
Published: February 2025

O presente artigo tem como objetivo abordar os principais aspectos tocantes ao procedimento de reforma constitucional, analisando o que discute a doutrina pátria sobre o tema, além de verificar se o panorama de excepcionalidade constitui um óbice circunstancial implícito à tramitação de uma Proposta de Emenda à Constituição, sobretudo em relação às PECs nº 10/2020 e 16/2020, convertidas nas Emendas Constitucionais nº 106 e 107/2020. Utiliza-se a metodologia de pesquisa qualitativa, com a análise de normas regulamentadoras do tema no ordenamento jurídico brasileiro e discussões levantadas pela doutrina pátria, tanto para reflexões quanto fundamentos embasadores do tema.
JURISTOCRACIA E CONSTITUCIONALISMO DEMOCRÁTICO: DO ATIVISMO JUDICIAL AO DIÁLOGO CONSTITUCIONAL
Authors: Montenegro Isaac Messias Santos
Published: February 2025

A presente resenha crítica analisa o trabalho individual mais recente de Glauco Salomão Leite: "Juristocracia e Constitucionalismo Democrático: do ativismo judicial ao diálogo constitucional". A partir dos movimentos históricos de formatação do Estado contemporâneo e da estruturação desenhada pela Constituição brasileira de 1988, o autor explica a atual dinâmica envolvendo o protagonismo do Judiciário e sua postura ativista no contexto democrático, com a transferência exponencial de poderes decisórios em relação às questões políticas, o que caracterizaria a ideia de “juristocracia”. À luz desse contexto, debatem-se as principais objeções majoritárias ao movimento, para, ao fim, propor uma postura dialógica de atuação judicial fundada nos diálogos constitucionais entre os poderes, que preserve a necessária independência judicial.
O CONSTITUCIONALISMO LATINO-AMERICANO E SUAS CONTRIBUIÇÕES PARA O RECONHECIMENTO DOS MOVIMENTOS SOCIAIS COMO NOVOS SUJEITOS DE DIREITO
Authors: Vasconcelos João Paulo de Carvalho
Published: February 2025

O artigo tem como objetivo analisar, por intermédio de metodologia dedutiva de revisão bibliográfica, as contribuições do novo constitucionalismo latino-americano para o surgimento de novos sujeitos de direito, notadamente os movimentos sociais, em especial o Movimento Nacional da População em Situação de Rua (MNPR). A problemática foi analisada em perspectiva decolonial, a partir do levantamento das raízes históricas que antecederam o surgimento do Estado Moderno, sua insuficiência para lidar com os problemas dos países latinos e a crise da modernidade. Finalmente, reflete-se acerca do pluralismo jurídico como elemento do novo constitucionalismo e como meio de articulação para o surgimento dos novos sujeitos de direito
O DIREITO À SAÚDE E A DIFICULDADE DE ADOÇÃO DE MECANISMOS PELO PODER JUDICIÁRIO PARA SUA IMPLEMENTAÇÃO: O USO DA DECISÃO COORDENADA NO ÂMBITO DO PROCESSO JUDICIAL
Authors: Soares Pedro Henrique Murta Rocha
Published: February 2025

O Sistema Único de Saúde, apesar de representar um dos maiores avanços trazidos com a Constituição Federal, enfrenta sérias dificuldades na plena consecução das políticas públicas. O Poder Judiciário se tornou um dos instrumentos mais utilizados pelos cidadãos para ter o acesso esperado dos serviços de saúde. A jurisprudência consolidou-se no entendimento de que a responsabilidade no cumprimento de tais obrigações seria solidária. Contudo, tal conclusão não foi suficiente. O trabalho se propõe a demonstrar como o uso da decisão coordenada pode ser uma alternativa viável para o imbróglio, diante da dificuldade em criar parâmetros universais para a questão.
O ATAQUE DA REFORMA TRABALHISTA À PROTEÇÃO CONSTITUCIONAL DO TRABALHADOR
Authors: Souza Carlos Alexsandro de Carvalho , Costa Flávio Luiz da
Published: February 2025

O artigo tem como objetivo avaliar como as mudanças na legislação trabalhista brasileira, produzidas pela Lei 13.467/2017, comprometem os princípios de proteção dos trabalhadores assegurados pela Constituição Federal de 1988. Os resultados indicam a ampliação dos riscos diante da terceirização irrestrita, da formalização de contratos de trabalho precários e dificuldades de acesso à justiça trabalhista, reforçando a agenda neoliberal de individualização dos riscos, em desacordo com Constituição Federal.
TECNOLOGIA E EDUCAÇÃO: CONSTRUINDO UM FUTURO INCLUSIVO E INTERDISCIPLINAR
Authors: Marins Aline Teixeira , Silva Cássia Fernandes da , Gomes Christoan Tonete , Barin Cláudia Smaniotto , Tristoni Jerry Silvio , Zerbinato Jéssica Alves , Oliveira Kaique de , Santos Leandro dos , Souza Lívia Barbosa Pacheco , Idalino Luana Ferreira , Canella Luciane Ferreira Idalino , Mondardo Luciane Lemos , Kauling Mara Rúbia , Silva Marcos Alexandre Rose , Leão Pedro Henrique Pinto , Tristoni Rejane Hauch Pinto , Rosa Rodrigo Garcia da , Magagnin Rosilane Bitencourt Marcelino , Teixeira Silvana Medeiros , Domingos Talita Silveira , Pupo Vanderlea Aguiar
Published: February 2025

O e-book intitulado TECNOLOGIA E EDUCAÇÃO: CONSTRUINDO UM FUTURO INCLUSIVO E INTERDISCIPLINAR foi desenvolvido por um grupo de educadores comprometidos com a melhoria contínua da educação. O e-book está organizado em diversas seções, abrangendo um amplo leque de temas que compõem o contexto educacional contemporâneo. A evolução tecnológica tem transformado a educação em um espaço de constante inovação, conectividade e inclusão, reunindo reflexões, pesquisas e práticas pedagógicas que abordam o impacto das tecnologias no ensino contemporâneo, promovendo um diálogo enriquecedor entre teoria e prática. Esta obra foi cuidadosamente organizada em capítulos temáticos que exploram tópicos essenciais para educadores, pesquisadores e gestores que buscam integrar a tecnologia de forma eficaz e ética no processo de ensino-aprendizagem.
DIGITAL HUMANISM IN THE AGE OF THE INTERNET AND ARTIFICIAL INTELLIGENCE: CHALLENGES, OPPORTUNITIES, AND PROSPECTS FOR DEVELOPMENT
Authors: Slyusar Mykyta , Nikitenko Vitaliia , Voronkova Valentyna
Published: February 2025

The relevance of this research topic lies in the evolving nature of digital humanism, a multifaceted and complex process aimed at achieving an optimal balance between the advancement of digital technologies and the preservation of human values and dignity. The study seeks to identify the conditions necessary for the conceptualisation of digital humanism in the era of artificial intelligence, and to analyse the challenges and opportunities associated with its development. The following research objectives are proposed: firstly, to clarify the essence, characteristics, and developmental trajectories of the concept of digital humanism; secondly, to examine the transformation of digital humanism in the context of the internet and artificial intelligence; thirdly, to establish the concept of digital humanism as a framework for harmonising technological advancement with the preservation of human potential; and finally, to explore cultural diversity as an embodiment of digital humanism and human values. Methodology. The study uses systemic, cross-cultural, axiological, anthropological and interdisciplinary approaches to provide a comprehensive analysis of digital humanism, facilitating an understanding of the interaction between digital technologies and humanity. A review of the literature shows that in the age of the Internet and artificial intelligence, digital humanism needs to be integrated into practical domains. This interdisciplinary research brings together philosophical, sociological, ethical and computer science perspectives to examine digital humanism in this transformative era. Artificial intelligence has opened up groundbreaking possibilities in fields such as medicine, education, transport and commerce. The study also highlights the European Digital Humanism Initiative and the methodology of informationalism, which illuminate the challenges and opportunities of digital humanism. Anthropological and socio-axiological approaches are used to analyse the value dimensions of the digital society, focusing on its impact on education, knowledge diffusion and innovation. Findings and implications. The results obtained provide a more profound comprehension of the genesis and pertinence of digital humanism in the context of societal transformation. This research underscores its capacity to address contemporary challenges while ensuring a harmonious coexistence of technological progress and human-centric values.
Intersemiotic Translation in Hypertext-Based Digital Communication
Authors: Li Qian
Published: February 2025

Against the digital backdrop, this research investigates the intersemiotic translation strategies of hypertext-based bilingual cultural publicity websites, seeking to address the intricacies of meaning-making in digital environments. It aims to probe into the efficient intersemiotic translation strategies regarding the intersection of Social Semiotics and translation studies. The case study explicates how to deploy hypertextual devices that adapt to target users' cultural norms and aesthetic preferences. The translation strategies (i.e. user-centered approach, compensation, addition, interdiscursive presentation, omission, and transcreation) were drawn on how hypertextuality facilitates dynamic navigation and intercultural communication. The findings indicate the application of multimodal discourse analysis in translation studies by revealing the potential of intersemiotic translation in promoting cross-cultural communication, digital literacy, and user experience in the digital sphere. The study contributes to the existing research by shedding light on the extension of research scope to multimodal translation, building a more holistic approach to website translation practice of cultural institutions.
Neurogenesis for the treatment of Alzheimer’s disease
Authors: Anushka Anil Kamble  , Omkar Sunil Lokhande
Published: February 2025

Alzheimer’s disease is a complex neurodegenerative condition marked by progressive cognitive impairment, memory deficits, and loss of neurons. Current treatment options primarily alleviate symptoms without targeting the root causes of the disease. Emerging research on adult neurogenesis, the generation of new neurons from neural stem cells has introduced innovative strategies for addressing the underlying pathology of Alzheimer’s disease. This review explores key aspects of neurogenesis, including its regulatory mechanisms, pharmacological interventions, and the role of natural products in enhancing neurogenesis. Additionally, it highlights the therapeutic potential of these approaches in mitigating Alzheimer’s disease progression. Challenges such as delivery barriers, safety concerns, and the translational gap between preclinical and clinical research are also discussed. Future studies integrating neurogenesis-based methods with existing therapies could transform Alzheimer’s disease management and improve patient outcomes.
The innocent Id: A psychoanalytic exploration of Jenny Curran's unconscious desires in Forrest Gump (1994) film
Authors: Dewanti Azzahra Safira , Kurniawan Fitri
Published: February 2025

This study examines the psychological complexity of Jenny Curran in Forrest Gump (1994) through a psychoanalytic lens, focusing on how unconscious desires influence her actions and relationships. Using Sigmund Freud’s concept of the Id, Ego, and Superego, the research explores the impact of childhood trauma and societal expectations on her self-destructive tendencies.A qualitative approach is employed, utilizing content analysis of key scenes that depict Jenny’s psychological struggles. Primary data includes dialogues, behaviors, and pivotal moments in the film, while secondary sources comprise psychoanalytic theory and literature on trauma and gender representation. The study interprets Jenny’s decisions through the tension between impulsive desires and moral reasoning, revealing that Jenny’s behavior is largely controlled by the Id, which seeks immediate gratification and escape from emotional distress. However, her Ego mediates between these desires and external reality, while her Superego reinforces guilt and internalized moral constraints. This psychological conflict shapes her unstable relationships, particularly with Forrest, as she alternates between seeking love and rejecting emotional security. Her journey illustrates the lasting effects of unresolved trauma and the unconscious forces that dictate human behavior.By analyzing Jenny’s character, this research enhances the understanding of female character development in film through psychoanalysis. It demonstrates how cinematic narratives depict internal struggles, offering insights into the portrayal of women’s experiences in media. Furthermore, it contributes to discussions on trauma, identity, and psychological depth in film storytelling, highlighting the role of unconscious motivations in shaping characters arcs. These findings underscore the significance of psychoanalytic film analysis in understanding how past trauma influences characters’ actions and relationships, providing a deeper perspective on the psychological complexities of female figures in films.
Analisis Profil Metabolit Ekstrak Etanol Daun Temelekar (Coptosapelta tomentosa Valeton ex K.Heyne) dengan Metode Spektroskopi FT-IR yang Dikombinasi dengan Kemometrik
Authors: Hikma Nurul , Burhan Asril , Megawati Megawati , Ulfah Nurhayati , Awaluddin Akbar
Published: February 2025

Daun temelekar (Coptosapelta tomentosa Valeton ex K.Heyne) telah dimanfaatkan dalam pengobatan antiinflamasi, malaria, keputihan dan diare. Pemanfaatan daun temelekar ini dikarenakan kandungan metabolit sekunder seperti antrakuinon, flavonoid, saponin, tanin, dan terpenoid. Namun kualitas dan kuantitas yang terkandung dalamnya bergantung pada iklim dan letak geografis dari lokasi tumbuhnya. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan senyawa metabolit aktif ekstrak etanol daun Temelekar dari berbagai lokasi menggunakan metode spestroskopi FT-IR dan kemometrik. Analisis profil ekstrak etanol dilakukan dengan FTIR program the unscrambler 10.5 dan minitab versi 18. Hasil dari analisis kemometrik, lokasi Kuaro dan Babulu (kelompok 1) memiliki kemiripan yaitu 85,19%, lokasi Lintang Jaya (kelompok 2) memiliki kemiripan 65,78% dengan kelompok 1, sedangkan lokasi Tanjung Batu (lokasi 3) memiliki kemiripan 39,66% dengan kelompok 2. Dengan demikian, dapat disimpulkan bahwa letak geografis berpengaruh terhadap kualitas dan kuantitas senyawa metabolit dari daun temeleker.
Validitas dan Reliabilitas Kuesioner Pengetahuan, Sikap, dan Perilaku Apoteker terhadap Pharmaceutical Care
Authors: Husna Ulviani Yulia , Ichsan Burhannudin
Published: February 2025

Pharmaceutical care didefinisikan sebagai pelayanan yang bertanggung jawab terhadap terapi obat dengan tujuan untuk mendapatkan hasil yang pasti serta  meningkatkan kualitas pasien. Pharmaceutical care menggambarkan tujuan dari farmasi klinik apabila dilihat dari praktek pofesional kefarmasian. Pharmaceutical care melibatkan peran Apoteker untuk mengembangkan rencana terapeutik yang akan menghasilkan hasil terapeutik yang spesifik untuk pasien. Tujuan dari penelitian ini adalah untuk membuat kuesioner standar siap pakai untuk penelitian tentang pengetahuan, sikap, dan perilaku apoteker tentang pharmaceutical care. Tiga puluh apoteker yang diberikan kuesioner untuk diisi menjadi sampel dalam penelitian ini. Sebuah teknik digunakan untuk mengevaluasi validitas kuesioner secara expert judgement sedangkan pada uji reliabilitas digunakan dengan melihat nilai korelasi item-total. Pengujian validitas instrument dengan expert judgment dihasilkan ada beberapa item pernyataan yang mengalami perbaikan kalimat. Sedangkan uji reliabilitas, item pernyataan pengetahuan ada 7 item yang memiliki nilai korelasi item-total > 0,20, pada item pernyataan sikap ada 22 item yang memiliki nilai korelasi item total > 0,20 dan pada item pernyataan perilaku ada 14 item yang memiliki nilai koralasi item total > 0,20. Hasil uji validitas dan reliabilitas instrumen dapat diterima untuk digunakan dalam menilai pengetahuan, sikap, dan perilaku apoteker terhadap pharmaceutical care.
Evaluation of the use of Favipiravir on the Hematology value of COVID-19 patients at Anna Bekasi Hospital in 2021
Authors: Setiadi Feri , T Ardy Tanfil , Widyastuti Widyastuti
Published: February 2025

The COVID-19 pandemic caused by the SARS-CoV-2 virus occurred in Indonesia in early 2020. Favipiravir was used as an antiviral for the disease due to an emergency. The results of routine hematological examinations of inpatients can be used as a parameter to predict the patient's risk of severity and the effect of using favipiravir antiviral. This study aimed to determine the effect of using favipiravir on hematological values in COVID-19 patients. The method used in this research is cross-sectional. The data collection method was carried out retrospectively with the data source in the form of medical records at Anna Bekasi Selatan Hospital in 2021. The total sample that included the inclusion criteria in this study was 83 patients. The results of the study between before and after the use of favipiravir in patients without comorbidities were significant differences in the values of the Neutrophil Lymphocyte Ratio (p: 0.003), Lymphocytes (p: 0.000), Platelets (p: 0.009) while in the value of hematocrit (p: 0.185) ) and hemoglobin (p:0.069) did not experience a significant difference. Patients with comorbid comorbidities using favipiravir had significant differences in hematological values, namely hemoglobin (p: 0.007), hematocrit (p: 0.004), platelets (p: 0.000) while the value of the Neutrophil Lymphocyte Ratio (p: 0.260) and lymphocytes (p: 0.234) did not experience a significant difference. Favipiravir is known to have a positive correlation with hematological values, in patients with COVID-19 infection without comorbidities using favipiravir it is known that the Neutrophil Lymphocyte Ratio value has decreased while the Lymphocyte and Platelet values have increased. However, it is known that the hemoglobin and hematocrit values did not experience a significant difference before consuming favipiravir and after consuming favipiravir.
Penentuan Kandungan Fenolik Total dan Model Klasifikasi Serbuk Rimpang Jahe Emprit (Zingiber officinale var. Amarum Roscoe) di Dataran Sedang dan Tinggi
Authors: Putra Harinditha Pramana , Ulfa Evi Umayah , Wulandari Lestyo
Published: February 2025

Jahe emprit (Zingiber officinale var. Amarum Roscoe) merupakan salah satu varietas jahe di Indonesia yang dimanfaatkan sebagai obat anti inflamasi, obat nyeri sendi, tonikum, serta obat batuk. Salah satu senyawa yang mempengaruhi khasiat dari jahe emprit adalah senyawa golongan fenol. Penelitian ini bertujuan menentukan kandungan fenolik total dan menentukan model klasifikasi menggunakan spketroskopi NIR dan kemometrik pada jahe emprit yang di tanam di dataran sedang dan dataran tinggi. Penentuan model klasifikasi menggunakan analisis multivariat LDA (Linear Discriminant Analysis), SVM (Support Vector Machines), dan SIMCA (Soft Independent ModeIIing of CIass AnaIyze), dan SVM (Support Vector Machines). Selanjutnya dilakukan validasi LOOCV (Leave-one-out cross-vaIidation) dan validasi eksternal. Penentuan fenolik total menggunakan spektroskopi uv-vis dengan reagen folin. Hasil rata-rata dari kandungan fenolik total pada dataran sedang adalah (23,592 ± 6,705) mg GAE/g serbuk, dan pada dataran tinggi adalah (13,382 ± 1,2700) mg GAE/g serbuk. Model klasifikasi LDA, SVM, dan SIMCA menghasilkan %akurasi sebesar 100%. Hasil validasi LOOCV model LDA dan SIMCA adalah 100%, dan SVM sebesar 60%. Hasil validasi eksternal model LDA dan SIMCA memiliki akurasi sebesar 100%. Setelah itu aplikasi pada sampel nyata pada model LDA dan SIMCA masing-masing memiliki akurasi sebesar 100%.
Peningkatan Performa Self Nanoemulsifying Drug Delivery System Daun Kelor (Moringa oleifera Lam) Menggunakan Metode Emulsifikasi Ultrasonic
Authors: Rusminingsih Esri , Susanto Hardhono , Afifah Diana Nur , Martien Ronny , Anas Yance
Published: February 2025

Daun kelor (Moringa oleifera Lam) diketahui mengandung polifenol yang tinggi berupa asam fenolat, flavonoid, dan glukosinolat yang telah terbukti memiliki aktivitas hipoglikemik. Studi menunjukkan bahwa 40% senyawa alami memiliki kelarutan yang rendah dalam air, yang memengaruhi bioavailabilitas senyawa alami dalam tubuh. Self Nanoemulsifying Drug Delivery System (SNEDDS) merupakan sistem penghantaran obat yang dapat meningkatkan kelarutan dan bioavailabilitas obat. Penelitian ini bertujuan untuk meningkatkan kinerja formulasi SNEDDS ekstrak daun kelor. Metode: Penelitian ini terdiri dari 3 tahap yaitu preparasi ekstrak, preparasi SNEDDS, dan karakterisasi nanoemulsi. SNEDDS dibuat menggunakan metode emulsifikasi ultrasonik. Bahan formulasi SNEDDS adalah asam oleat: Tween 20: polietilen glikol (PEG) 400 dengan perbandingan 1:8:1. Ada tiga konsentrasi ekstrak daun kelor berbeda yang digunakan dalam penelitian ini yaitu 75 mg, 100 mg, dan 125 mg per 3 ml dalam formula dasar SNEDDS. Formula dihomogenkan menggunakan hotplate magnetic stirrer pada suhu 400C selama 30 menit, kemudian disonikasi selama 15 menit pada suhu 400C. Hasil penelitian menunjukkan rata-rata ukuran partikel pada konsentrasi 75 mg, 100 mg dan 125 mg adalah 14,40 nm, 22,99 nm dan 86,48 nm dengan polidispersitas (Pdi) masing-masing 0,41; 0,67; 0,20. Meskipun konsentrasi 125 mg memiliki rata-rata ukuran partikel terbesar yaitu 86,48 nm, namun memiliki konsentrasi ekstrak daun kelor tertinggi, Pdi terbaik dan zeta potensial -32,6 mV. Formula SNEDDS ekstrak daun kelor terbaik terdapat pada dosis 125 mg/3ml telah memenuhi parameter nanoemulsi yang dapat dikembangkan sebagai terapi komplementer dari bahan alam.
Characterization of Ethanolic Extract of Saluang belum (Luvunga sarmentosa Kurz) Root
Authors: Rizaldi Gusti , Wati Helmina , Muthia Rahmi , Amadia Selvi , Hayati Farida , Jumaryatno Pinus
Published: February 2025

Saluang belum (Luvunga sarmentosa Kurz) is a member of the endemic plants of Central Kalimantan, which the local community has traditionally used as a traditional medicine to cure several kinds of diseases. Characterization of the ethanolic extract of Saluang belum root is needed to facilitate the consistency of safety and quality. Therefore, this research needs to be carried out to complete the data on the characterization of the ethanolic extract of Saluang belum root. The material used is Saluang belum root collected from Palangkaraya, Central Kalimantan, Indonesia. There is no standard for Saluang belum extract. The results showed that name of the extract was Sarmentosa radix extractum; Indonesian name was Saluang belum; Latin name was Luvunga sarmentosa Kurz; part that used was root; reddish dark brown colour; typical smell; bitter flavour; contains carbohydrate, allylic alcohol and terpenoid compounds; density 0,82 g/ml; water content 4,865%; total ash content 1,74%; acid insoluble ash content 0,31%, negative residual solvent; Pb contamination 3,206 mg/kg; Cd contamination <0,001 mg/kg; total plate count 1,0 x 102 colonies/g; mold contamination 1,0 x 102 colonies/g; yeast contamination < 1,0 x 100 colonies/g.
Identifikasi DRPs dan Analisis Biaya Terkait Peresepan Antibiotik dalam Besaran Kapitasi di Puskesmas Kota Cirebon-Indonesia
Authors: Rahmania Rizka , Setiawan Didik , Siswanto Agus
Published: February 2025

Penggunaan antibiotik yang tidak rasional merupakan salah satu Drug Related Problems (DRPs) yang dapat mengganggu luaran. Tujuan penelitian ini adalah mengidentifikasi dan mengklasifikasikan DRPs pada tiap lembar resep beserta nilai biaya obat pada resep yang dilayani puskesmas di Kota Cirebon. Penelitian ini dilakukan terhadap resep antibiotik di 18 puskesmas Kota Cirebon. Sampel yang digunakan adalah resep pasien dewasa (Januari-Desember 2019) dengan diagnosa utama penyakit infeksi saluran pernafasan akut (ISPA) tidak spesifik (J069), diare tidak spesifik (A09), nasofaringitis akut (J00) dan faringitis akut tidak spesifik (J029). Sebanyak 1478 DRPs teridentifikasi dari 761 lembar resep dengan tingkat kejadian rata-rata 2,2 DRPs per lembar resep. Persentase kejadian DRPs yang teridentifikasi antara lain DRPs terkait pemilihan obat sebesar 94,65%, dosis yang tidak sesuai sebesar 4,26% dan durasi pengobatan yang tidak sesuai sebesar 1,08%. Hasil penelitian menunjukkan rata-rata biaya obat sebesar Rp. 10.223/lembar resep, yaitu lebih tinggi dibandingkan dengan biaya obat standar sebesar Rp. 4.835. Tingginya angka kejadian DRPs berpotensi dalam menyumbang inefisiensi penggunaan anggaran di puskesmas.
Medication Adherence among Acute Coronary Syndrome Outpatients at Sardjito Hospital in 2019
Authors: Zulpadly M Fiqri , Ermawati Dian Eka , Sasongko Heru
Published: February 2025

Worldwide, heart disease accounts for the majority of deaths. One of the indications of coronary illness is Acute Coronary Syndrom (ACS) STEMI. With a prevalence rate of 7.2%, Indonesia still has the highest ACS incidence, and it continues to rise annually. Several factors are involved in reducing the mortality rate of ACS, namely by controlling several risk factors that can reduce the incidence and improve treatment. This study aims to determine the level of adherence to drug use in patients who are registered with new STEMI and outpatients at Sardjito Hospital Yogyakarta. The research method used in this study was non-experimental analytic observational with a retrospective cohort design. Measurement using the Medication Possession Ratio (MPR) method. The study population was patients who were registered for the first ACS diagnosis since January 2017 and followed the course of their treatment until the patient stopped using the drug or the end of observation (31 December 2018). The number of samples obtained according to the inclusion criteria was 495 patients. Adherence to the use of antithrombotic drugs was greater in female patients (82.4%), age < 60 years (88.4%), and patients using combination antithrombotic therapy regimens (81.4%). Statistical significance was shown in the category of gender (Log Rank = 0.046) and treatment regimen (Log Rank = 0.005). However, the age category did not show statistical significance (Log Rank = 0.289). The conclusion of this study is that adherence to the use of antithrombotic drugs in STEMI patients is influenced by gender and therapeutic regimen.
Optimasi Formula Fast Disintegrating Tablet Domperidone Kombinasi Filler Binder Starch 1500, Manitol dan Avicel PH 102 dengan Simple Lattice Design
Authors: Novi Novi , Siswanto Agus , Rahayu Wiranti Sri
Published: February 2025

Domperidone adalah agonis anti-dopamin yang digunakan untuk mengontrol  muntah. Salah satu pengembangan formulasi domperidone kerja cepat adalah dengan formulasi dalam bentuk fast disintegrating tablet. Penelitian ini bertujuan mendapatkan komposisi optimum Starch 1500, manitol dan Avicel PH 102 pada sediaan FDT (fast disintegrating tablet) domperidone. Metode simplex lattice design dengan software Design expert diterapkan dengan 3 variabel sehingga diperoleh 14 run formula. Tablet dibuat dengan metode cetak langsung. Tablet diuji mutu meliputi: sifat alir massa cetak, sifat fisik tablet, waktu pembasahan, dan uji disolusi. Hasil penelitian menunjukkan bahwa Avicel PH 102 merupakan faktor yang dominan meningkatkan sifat alir, mempercepat waktu pembasahan, meningkatkan waktu hancur, dan meningkatkan disolusi FDT  Domperidone. Manitol merupakan faktor yang meningkatkan kekerasan dan kerapuhan tablet. Optimasi dengan metode numerik menghasilkan komposisi formula optimum FDT domperidone dengan Starch 1500 11,0316 mg, manitol 42,541 mg, dan Avicel PH 102  117,427 mg dengan nilai disirability 0,773.
Analisis Hubungan dan Pengaruh Kemampuan Kerja dan Motivasi Terhadap Kinerja Karyawan PT Astra Internasional Daihatsu Cabang Bintaro
Authors: Ningrum Fadia Ayu , Nomleni Anton P W
Published: February 2025

Kinerja karyawan merupakan salah satu hasil kerja yang dilakukan oleh seseorang, dengan menjalankan kewajiban dengan tanggung jawab yang telah diberikan kepadanya dengan melakukan pekerjaan yang sesuai dengan tujuan yang diharapkan. Faktor dalam meningkatkan kinerja yang berkualitas yaitu dengan adanya kemampuan kerja dan motivasi pada diri karyawan. Pada penelitian ini dilakukan untuk menguji kemampuan kerja dan motivasi terhadap kinerja karyawan. Objek dari penelitian ini adalah PT Astra Internasional Daihatsu Cabang Bintaro dengan populasi 96 orang karyawan. Data yang digunakan yaitu dengan teknik analisis data kuantitatif, sedangkan teknik analisis data menggunakan analisis linear berganda, uji t dan uji f dengan taraf signifikan 0,05%., dengan menggunakan bantuan aplikasi SPSS 26.
Analisis Kinerja Keuangan Sebelum dan Saat Pandemi Covid-19 Pada PT. Astra International Tbk
Authors: Wardani Niken Resti , Hendrawati Erna
Published: February 2025

Penelitian ini menganalisis kinerja keuangan sebelum serta saat terjadinya pandemi Covid-19 pada PT. Astra International Tbk tahun. Tahun 2017 – 2019 ialah tahun sebelum ada pandemi Covid-19 serta 2020 – 2021 tahun ketika ada pandemi Covid-19. Variabel yang digunakan sebagai indikator kinerja keuangan adalah Rasio Likuiditas yang terdiri atas Current Ratio dan Quick Ratio, Rasio Solvabilitas yang terdiri dari Dept to Asset Ratio dan Dept to Equity Ratio, Rasio Profitabilitas yang terdiri dari Net Profit Margin, Return on Asset dan Return on Equity, Rasio Nilai Pasar yang dipakai pada ini ialah Earning Per Share dan Revanue (Sales) Growth. Hasil penelitian Sebelum terjadinya pandemi Covid-19 yaitu di tahun 2017, 2018 serta 2019 beberapa rasio yang keadaannya lebih baik daripada saat pandemi Covid-19 yaitu Rasio Profitabilitas dan Rasio Nilai pasar. Pada ketika ada pandemi Covid-19 yakni di tahun 2020, beberapa indikator kinerja keuangan mengalami penurunan seperti RGR, DAR, DER ROA, dan ROE, PT. Astra International berhasil mempertahankan nilai NPM selama pandemi Covid-19. Beberapa memiliki dampak baik bagi perusahaan yaitu penurunan nilai DAR dan DER di ketika pandemi Covid-19. Namun, setelah ada pandemi Covid-19 perusahaan kembali meningkat seperti RGR, NPM, ROA, ROE, EPS meskipun nilainya tidak sebanyak sebelum ada pandemi Covid-19. Di tahun 2021 sesudah ada pandemi Covid-19 beberapa rasio yang memiliki nilai lebih baik setelah terjadinya pandemi Covid-19 yakni Current Ratio, Quict Ratio, Dept to Asset dan Dept to Equity
Analysis of Mosques Financial Management Practices in Gowa Regency, Indonesia
Authors: Suarni Agusdiwana , Wahyuni Sri , Nurlina Nurlina
Published: February 2025

This study aims to determine how the Practice of Mosque Financial Management in Bajeng District, Gowa Regency. This study interviewed 3 mosque administrators, namely: Mosque Chairman, Mosque Secretary and Mosque treasurer. The type of research used in this research is descriptive qualitative research. Data collection techniques are obtained through observation, interviews and documentation. The data obtained are secondary data and primary data. The finding of this research which are (1) budget planning, the mosque in Limbung Village is only the Limbung Grand Mosque which does budget planning regularly and others only do plan when there are activities or mosque construction and some have never even done a budget plan. (2) fund management, the source of mosque income is dominated by Friday infaq and other income such as donors and in the month of Ramadan there is also Amalia Ramadhan. Mosque expenditures are mostly used for mosque operations as well as the construction and physical maintenance of the mosque. (3) internal control, all mosques have used evidence such as notes / receipts for recording and reporting their finances, although financial reports still use simple financial reports and are made manually but mosque administrators are transparent by submitting financial reports every Friday before Friday prayers. Budget evaluation is still a lot of mosques that have never done it and only done by a few mosques in Limbung Village and even then, it is done when there are big activities, while for audits, quite a lot of mosques in Limbung Village have done it where financial reports made by the treasurer will be checked by the head of the mosque management.
Profiling Pengukuran: Return On Invested Capital dan Intellectual Capital
Authors: Puspitasari Elen , Widati Listyorini Wahyu , Suwarti Titiek , Meiranto Wahyu
Published: February 2025

The research aims to compile a profile of disclosure measurement of return on invested capital and intellectual capital in banking companies with the observation period of 2020 – 2022. The sample was determined by purposive sampling that resulted in 84 observation data from 28 companies The findings of this study confirm that measuring intellectual capital with the comprehensive tool, namely Modified Value Added Capital suggests that there is a positive and significant effect on the return on invested capital. A company with a high value added intellectual capital will increase Return On Invested Capital has the ability to reinvest its profits and grow its business, resulting in long-term earnings growth and potentially higher returns for investors. The average ROIC was 7.54% (>2%), which shows that management uses funding efficiently to generate profits. Therefore, management must reinvest the surplus profits in the company to drive future growth.Keywords:Return on Invested Capital; Modified Value Added Intellectual Capital; Banking Industries.
Determinan Wajib Pajak Dalam Melakukan Tax Avoidance
Authors: Ayem Sri , Putri Fuadhillah Kirana , Dewi Regita Septiyana , Azkiah Cia Zulviatul
Published: February 2025

Pajak merupakan sumber pemasukan negara yang terbesar dan dapat meningkatkan pembangunan negara. Pajak memegang peranan yang penting dalam pembangunan suatu negara. Karena itu, pajak merupakan suatu permasalahan penting yang perlu dikembangkan lebih lanjut dan diupayakan dengan maksimal di Indonesia. Namun, dalam praktiknya terdapat wajib pajak yang berkeinginan meminimalisir pembayaran pajak memalui tindakan tax avoidance yang ilegal. Artikel ini bertujuan untuk mengkaji faktor-faktor yang menentukan kemampuan penggelapan pajak bagi wajib pajak. Artikel ini ditulis dengan mereview 26 artikel dengan data sekunder yang diperoleh menggunakan software Harzing Publish or Perish 8 pada Google Scholar. Berdasarkan dari artikel-artikel yang diteliti, tampak adanya perubahan fenomena yang mendefinisikan Tax Avoidance sebagai perbuatan melawan hukum. Selain itu, jika wajib pajak mempunyai karakter yang buruk maka ia akan melakukan Tax Avoidance dan tidak segan-segan melakukan perbuatan menyimpang atau melanggar aturan perpajakan.
Systematic Literature Review (SLR): Efektivitas Penggunaan QRIS sebagai Alat Transaksi
Authors: Kartika Cahyaning Enggar , Arum Puspawati Rista
Published: February 2025

Teknologi informasi yang berkembang saat ini dimanfaatkan oleh para pelaku bisnis untuk mengembangkan bisnisnya dengan menyediakan layanan transaksi digital. Salah satu layanan transaksi secara digital yang saat ini marak digunakan adalah Quick Response Code Indonesia Standard (QRIS). QRIS merupakan standar kode Quick Response Code (QR Code) terpadu yang diadopsi pemerintah Indonesia yang memungkinkan berbagai instrument pembayaran, seperti dompet digital, aplikasi perbankan seluler, dan metode pembayaran lain. Penelitian ini memiliki tujuan untuk mengkaji literatur review terkait dengan efektivitas penggunaan QRIS. Penelitian ini menggunakan metode Systematic Literature Review (SLR). Artikel yang relevan dan penelitian yang sesuai dengan topik didokumentasikan guna mendukung pengumpulan data. Artikel jurnal nasional yang digunakan dalam penelitian ini sebanyak 15 artikel yang diperoleh dari database Google Scholar melalui aplikasi Publish or Perish. Sesuai dengan kajian literatur yang dilakukan, penggunaan QRIS memungkinkan transaksi yang lebih efektif.
Assessment of water-physical properties of soil for the cultivation of pomegranate varieties in dry subtropics
Authors:   Subtropical Scientific Center of the Russian Academy of Sciences, Sochi, Russian Federation, Zagirov N.G. , Trunov Y.V. ,   Michurinsk State Agrarian University, Michurinsk, Russian Federation
Published: February 2025

Abstract. The purpose of the research was to study the water regime of meadow chestnut soil in the conditions of Southern Dagestan in connection with the use for pomegranate plantations. Generally accepted methods were used for studying the soil of the experimental sites: the morphological description of the soil was
carried out according to Golubev I.F.; the structural composition – according to N.I. Savinov; the mechanical
composition – by the method of N.A. Kachinskiy; the soil density – by the device of N.A. Kachinskiy; the
specific gravity – by the technometric method; the lowest moisture capacity of the soil – by flooding the area
according to N.A. Kachinskiy; the permanent wilting point – by the method of seedlings according to S.I.
Dolgov in natural conditions, i.e. directly on pomegranate plantations; the maximum hygroscopic moisture
– according to the method of A.V. Nikolaev; the moisture content at capiillary rupture was calculated according to the method of S.I. Dolgov; the soil filtration – according to the method of N.A. Kachinskiy. For
the first time, the permanent wilting point threshold of the pomegranate plant (8.5 %) was established and
the ability of the pomegranate plant to assimilate the maximum hygroscopic moisture of the soil was revealed.
It has been established that the regulation of the water regime of the soil is the main link on which the efficiency of other factors depends. In arid areas, the use of fertilizers and machinery, without improving the
water regime, cannot ensure a high yield. The assessment of the optimality of soil conditions and limiting
factors in the cultivation of introduced pomegranate varieties showed that the specific gravity of the soil,
depending on the depth of sampling, is 2.6-2.72 g/cm3
, the soil density is 1.26-1.31 g/cm3
, the absolute moisture content is 14.1-25.0 %, the porosity is 41.2-57.2 %, the physical sand is 52.4-60.6 %, the physical clay
is 39.4-47.6 %, the lowest moisture capacity is 20.6-26.2 %, and the permanent wilting point is 11.4-17.9 %.
Positive correlations were obtained between the depth of soil sampling on the one hand and the specific
gravity of soil particles (r = 0.53), the soil density (r = 0.65), the absolute soil moisture (r = 0.93), the porosity (r = 0.90), the physical sand (r = 0.94), the physical clay in the soil (r = 0.95), the lowest moisture capacity
(r = 0.97), and the permanent wilting point (r = 0.90). In the irrigated conditions of the dry subtropics of
Southern Dagestan, characterized by aridity, the exchange of heat and light to obtain annual guaranteed yields
of high-quality fruits of introduced pomegranate varieties, the optimal irrigation regime is 80 % of the FMC.

Keywords: Southern Dagestan, dry subtropics, water regime, pomegranate culture, limiting factors, correlation coefficient
Utilization of Short-form Music Content and Musical Experiences: A Comparative Analysis Across University Students
Authors:   The Korean Society of Music Education Technology, Kim So Hyung , Bae Su-Young
Published: February 2025

This study aims to analyze the usage patterns of short-form music content among university students and to explore the differences in musical experiences and activities based on viewing time, major, and user characteristics. Analysis of data from 182 university students revealed that more than 65% of the respondents watched short-form content for more than one hour per day, and longer viewing times were associated with more active engagement in musical discovery, creation, and interaction. A comparison between music majors and non-music majors showed that music majors utilized short-form content more actively for creative and learning activities, while non-music majors focused more on musical discovery and forming new hobbies.
Additionally, the cluster analysis revealed that the active user group scored higher in all musical activity domains compared to the less active user group, with notable differences observed in communication, hobby formation, and musical change. This suggests that the level of short-form content usage significantly impacts the breadth and depth of musical experiences.
This study confirms that short-form music content can be a valuable tool for expanding university students' musical experiences and promoting creative learning and social interaction. Future research should analyze the long-term effects of short-form content usage and explore strategies to connect it with creative and in-depth learning in various educational contexts.
Development and Effectiveness Verification of Music History Lessons Incorporating Storytelling and Games
Authors:   The Korean Society of Music Education Technology, Yoon Sion , Chu Heesun
Published: February 2025

The purpose of this study is to propose instructional strategies for applying storytelling game-based learning in high school music classes to enhance learners' interest and facilitate effective learning. For this purpose, animated videos were created using the “Keynote” program, incorporating dubbed characters to produce engaging learning materials. A total of 72 first-year high school students were divided into a control group, which received traditional lecture-based instruction, and an experimental group, which participated in storytelling game-based learning. Pre- and post-tests were conducted one week before and after the lessons, and interviews were conducted with four students from the experimental group to examine comprehension, interest, differentiation from other classes, and preferences. The results revealed that the experimental group achieved significantly higher scores on the post-test compared to the control group, indicating that storytelling game-based learning had a meaningful impact on comprehension. Furthermore, interviews showed that learners developed a more positive perception of Western music history. This method not only enhanced comprehension but also encouraged active participation, with learners highlighting the unique and engaging aspects of storytelling elements, such as animation and dubbing, which made the lessons enjoyable.This study suggests that storytelling game-based learning is an effective approach to improving the quality of music education and fostering active, learner-centered classroom environments.
The Design and Application of Music Appreciation Classes in High School Centered on the Music Curriculum and Universal Design for Learning
Authors:   The Korean Society of Music Education Technology, Hong Inhye , Yoon Sungwon
Published: February 2025

The purpose of this study is to design and apply high school music appreciation classes centered on the music curriculum and Universal Design for Learning. This study focuses on the music appreciation class, which has not been well dealt with in previous studies, although there have been needs and demands in the high school field. In other words, this study aims to provide a method of music appreciation classes that may be used immediately by music teachers in the high school field. First, the researchers analyzed the music curriculum to be suitable for the high school field and suggested the method of the music appreciation class. This is a summary of the music appreciation class method code. In addition, the option code for applying Universal Design for Learning, a learning theory that is considered appropriate for applying it in the high school field, is also summarized. As the result of the study, these two codes (music curriculum codes and Universal Design for Learning codes) were combined to represent a total of 8 sessions of the high school  subject, which is a general elective subject of the selection-oriented curriculum. Based on the music appreciation class plan presented in this study, it is expected that more diverse teaching plans will be prepared in the future.
Behavioral Human Factors in Non-Invasive Health Monitoring
Authors: Nino Valentina
Published: February 2025

Non-invasive health monitoring technologies, such as continuous glucose monitors and wearable heart rate sensors, have revolutionized the way we manage health by offering real-time data without the need for invasive procedures. However, the success and accuracy of these devices are not solely dependent on technological advancements. Behavioral human factors, including user-centered design, psychological drivers, and behavioral aptitudes, play a crucial role in their effectiveness. This opinion paper explores the intersection of technology and human behavior, emphasizing how user habits, health literacy, and engagement influence the reliability and adoption of non-invasive health monitors
Peer Relationships and Student Motivation: Theoretical and Methodological Approaches, Empirical Evidence, and Future Directions
Authors: Daumiller Martin , Hemi Alla
Published: February 2025

Background: Motivation is central for student learning and achievement, yet it does not operate in isolation. Peer relationships play a fundamental role in shaping students' motivation, engagement, and academic development. Explicit investigation of the interplay between motivation and peer relationships is scarce, with especially the reciprocal and dynamic nature of these interactions still being little understood and of subject of the present issue.Aims: This special issue aims to bridge theoretical and methodological gaps in understanding how peer relationships shape and are shaped by student motivation. We explore key questions regarding the relevance of peer relationships in motivation research, the theoretical and methodological approaches applicable to this intersection, and cultural considerations in studying these dynamics.Samples and Methods: The special issue comprises 22 empirical and conceptual studies from diverse cultural and educational contexts, including primary, secondary, and higher education settings from multiple countries. Contributions employ varied methodologies, including longitudinal designs, social network analysis, qualitative interviews, and experience sampling, and experimental designs. Results: Findings highlight the bidirectional nature of peer relationships and motivation. Studies reveal that peer support, social norms, and network positioning influence motivation and academic outcomes, while students' motivational orientations also shape their peer interactions. Cultural variations suggest that the impact of peer dynamics on motivation differs based on sociocultural contexts. We synthesize these different pathways into a conceptual model.Conclusion: This special issue underscores the need for an integrative, interdisciplinary approach to studying peer relationships and student motivation. Future studies should explore their reciprocal nature using dynamic methodologies. Understanding these interactions can inform interventions to foster motivation and engagement in educational settings.