bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated UPLC-MS/MS and UHPLC-Q-orbitrap HRMS Analysis to Reveal Pharmacokinetics and Metabolism of Five Terpenoids from Alpiniae oxyphyllae Fructus in Rats
Authors: Zuo Lihua , Li Jia , Xue Lianping , Jia Qingquan , Li Zhuolun , Zhang Mengya , Zhao Mengfan , Wang Mengli , Kang Jian , Du Shuzhang , Sun Zhi
Published: December 2020

Background:

Alpiniae oxyphyllae Fructus (AOF), a traditional Chinese medicine (TCM), is widely used in the treatment of urinary, gastrointestinal and neurologic diseases in China. Although terpenoids are the main active ingredients of AOF, there are few researches on their pharmacokinetics and metabolism.

Methods:

In this study, a sensitive, rapid, accurate and novel ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established to evaluate the pharmacokinetic behavior of five terpenoids (oxyphyllenodiol B, (4S*,5E,10R*)-7-oxo-tri-nor-eudesm-5-en-4β-ol, 7-epi-teucrenone, (+)- (4R,5S,7R)-13-hydroxynootkatone, (E)-labda-12,14-dien-15(16)-olide-17-oic acid) in rats after oral administration of AOF extracts. 27 metabolic metabolites of the five terpenoids were identified by ultra high performance liquid chromatography -Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) based on precise mass and fragment ions.

Results:

The established pharmacokinetic analysis method showed good linearity over a wide concentration range, and the lower quantitative limit (LLOQ) ranged from 0.97 to 4.25 ng/mL. Other validation parameters were within the acceptable range. In addition, 27 metabolites were identified in plasma, urine and feces samples, and the metabolic pathways of five terpenoids were mainly focused on glucoside conjugation, dehydration, desaturation and glycine conjugation.

Conclusion:

This is the first study on the pharmacokinetics and metabolism of five terpenoids in AOF, illuminating the disposal process of terpenoids in vivo. It was expected that the results of this study would provide some references for the apprehension of the action mechanism and the further pharmacological study of five terpenoids in AOF.
The Frequency of Random Findings on Abdominal/Pelvis Computed Tomography in Pediatric Trauma Patients
Authors: Baştuğ Betül T.
Published: December 2020

Aims:

In this study, we aimed to find the percentage of random pathologies and abdominopelvic
region anomalies that are not related to trauma in pediatric patients.

Background:

An abdominal assessment of an injured child usually involves computed tomography
imaging of the abdomen and pelvis (CTAP) to determine the presence and size of injuries. Imaging
may accidentally reveal irrelevant findings.

Objectives:

Although the literature in adults has reviewed the frequency of discovering these random
findings, few studies have been identified in the pediatric population.

Methods:

Data on 142 (38 female, 104 male) patients who underwent CTAP during their trauma
evaluation between January 2019 and January 2020 were obtained from our level 3 pediatric trauma
center records. The records and CTAP images were examined retrospectively for extra traumatic
pathologies and anomalies.

Results:

67 patients (47%) had 81 incidental findings. There were 17 clinically significant random
findings. No potential tumors were found in this population.

Conclusion:

Pediatric trauma CTAP reveals random findings. For further evaluation, incidental
findings should be indicated in the discharge summaries.
Photocatalytic Degradation of Methyl Orange Dye with Synthesized
Chitosan/Fe2O3Nanocomposite and its Isotherm Studies
Authors: Jadon Nimisha , Bhat Gulzar Ahmad , Sharma Manoharmayum Vishwanath , Sharma Harendra Kumar
Published: December 2020

:

Background: The study focuses on the synthesis of chitosan/Fe2O3 nanocomposite, its
characterization and application in methyl orange dye degradation. Methods: The synthesized chitosan/
Fe2O3 nanocomposite was characterized with Powder X-Ray Diffraction, Fourier
Transfor-­‐
mation
Infrared
Spectroscopy (FTIR), Transmission
Electron
Microscopy
(TEM)
and
UV-­‐Vis
Spectroscopy.
Results:
The
characterization
showed
that
the
Fe2O3nanoparticles were embedded
in the polymer matrix of chitosan. The size of the Fe2O3nanoparticles was less than 10nm and the
crystallite size was 1.22 nm. The
synthesized
chitosan/Fe2O3nanocomposite was tested for methyl
orange degradation using different parameters such as the effect of contact time, effect of dose, effect
of concentration and effect of pH for the degradation of methyl orange dye in aqueous solution. The
Fruendlich, Langmuir and Temkin isotherm studies were also conducted for adsorption of methyl
orange on Chitosan/Fe2O3nanocomposite. Conclusion: The
study
indicated
that
the
synthesized
chitosan/Fe2O3 nanocomposite had the potential of degrading methyl orange dye up to 75.04% under
the set condition in this experiment, which indicates that Chitosan/Fe2O3 nanocomposite is a viable
option that can be used for the degradation of methyl orange dye.
Demonstration of Advanced Data Mining Tools for Optimization of Pellets Employing Modified Extrusion-pelletization Technique
Authors: Rana Hardika , Dholakia Mansi , Gohel Mukesh , Omri Abdelwahab , Thakkar Vaishali , Gandhi Tejal
Published: December 2020

Background:

The multi particulate drug delivery system is preferred due to its numerous
advantages but the batch to batch consistency and to achieve desired physical properties are the major
challenges in the formulation of such dosage form.

Objective:

The objective of the present study was to explore the concept of quality by design for the
development of galantamine HBr controlled release pellets using a modified palletization technique.

Methods:

Compritol 888 and Ethocel were chosen as hydrophobic release retardants, while Avicel
was chosen as pelletization aid. A compatibility study was conducted between the drug and excipients.
Drug loaded extrudes were prepared by using a mixture of isopropyl alcohol, and dichloromethane.
Before converting the wet extrudes into pellets, pregelatinized starch was sprinkled on them to improve
the physical properties of the pellets. The pellets were characterized for size, shape, and flow.
The critical evaluation parameter was the drug dissolution pattern in distilled water. The dissolution
data were treated with advanced data mining techniques. The in-vivo profile was predicted employing
pharmacokinetic parameters of the drug and in-vitro drug release data of optimized batch pellets.

Results:

The failure mode and effect analysis revealed that the amount of Compritol 888 ATO and
Ethocel were the most critical formulation parameters. The results of FTIR and DSC revealed compatibility
between the drug and the excipients. The spherical pellets exhibited good flow. The drug dissolution
studies of the batches, prepared according to the central composite design, revealed modified
drug release. Multiple regression analysis and analysis of variance were performed to identify statistically
significant factors. Contour plots demonstrated the impact of the amount of Compritol 888 and
ethyl cellulose. The Design-Expert software was used to identify optimized formulation. The predicted
in-vivo plasma concentration-time profile revealed the modified drug release up to 12h.

Conclusions:

Compritol and Ethocel were able to retard the drug release up to 12 hrs in distilled water.
The innovative finding of this study is the use of a dry binder (pregelatinized starch) to improve the
characteristics of pellets. Other dry binders are expected to show a similar effect. The newer processing
technique can be of use in the industry.
Donor-recipient Matching in Heart Transplantation
Authors: Oprzędkiewicz Aleksandra , Mado Hubert , Szczurek Wioletta , Gąsior Mariusz , Szyguła-Jurkiewicz Bożena
Published: December 2020

Heart transplantation remains the treatment of choice for end-stage Heart Failure (HF). Due to the shortage of organs for transplantation and the occurrence of perioperative complications, a key problem is donor matching, which should result in increased survival and improved quality of life for patients. The success of this procedure depends on various parameters such as gender, weight, ABO blood group and Human Leukocyte Antigen (HLA) system of both the recipient and the donor. Furthermore, non-HLA antigens may also be valuable in donor-recipient matching. The aim of this article is to summarize the recent knowledge on the impact of various factors on accurate donor-recipient matching to heart transplantation.
Tectonic Keratoplasty in Patients with Non-traumatic, Non-infectious Corneal Perforations
Authors: Cikmazkara Ipek , Selver Ozlem B. , Palamar Melis , Egrilmez Sait , Yagci Ayse
Published: December 2020

Introduction:

The study aims to report clinical results of tectonic keratoplasty for non-traumatic, non-infectious corneal perforations.

Materials and Methods:

The medical records of 12 patients who underwent tectonic penetrating keratoplasty between October 2014 and August 2018 at Ege University Ophthalmology Department were retrospectively reviewed.

Results:

The mean age of the patients was 52.92±30.34 (range, 2-82) years. The causes of corneal perforation were dry eye (neurotrophic keratopathy (n=4), limbal stem cell deficiency (n=2), exposure keratopathy (n=2) and graft versus host disease (n=1)) in 9 patients. In the remaining 3 patients, the etiology of perforation was not determined. The mean Visual Acuity (VA) was 2.98±0.39 (range, 1.8-3.1) LogMAR before the surgery. Despite conservative treatment, tectonic penetrating keratoplasty had to be performed in all patients in order to manage the perforation. Mean time in between initial examination and surgery was 10.75±12.04 (1-41) days. In 2 patients, allogenic limbal stem cell transplantation; in one patient, lateral tarsorrhaphy and in one patient symblepharon release with amniotic membrane transplantation were performed additional to tectonic keratoplasty. Mean follow-up time was 57.88±55.47 (4-141) weeks. Grafts were clear in 6 eyes and opaque in 5 eyes. The main causes of graft failure among opaque grafts were ocular surface disease (3), allograft rejection (1) and glaucoma-related endothelial failure (1). Phthisis bulbi was detected in one patient with congenital glaucoma due to vitreous loss at the time of perforation. The mean final VA in patients who had clear grafts was 1.83±1.03 (range, 0.8-3.1) LogMAR.

Conclusion:

To prevent serious complications in non-traumatic, non-infectious corneal perforations, providing anatomic integrity immediately is a must. If conservative treatment is inadequate or the perforation area is extensive, tectonic penetrating keratoplasty is indicated. Besides, it is important to manage the etiological risk factors in order to obtain successful clinical follow up.
An Exploration of Absenteeism among Nursing Students in the context of a South African University
Authors: Randa Moreoagae Bertha
Published: December 2020

Background:

Absenteeism among university and college students is a global challenge. Not only does absenteeism result in inadequate learning, but it also disrupts the way in which classes are conducted.

Objective:

The study sought to explore and understand the reasons for absenteeism from the perspectives of the nursing students in the context of a South African University.

Methods:

The study used an explorative qualitative design to conduct four focus group discussions with undergraduate nursing students. Tesch’s method of data analysis was followed.

Results:

One theme and four sub-themes emerged, such as the negative attitudes of lecturers, poor guidance and lack of prompt feedback from lecturers, lack of commitment from lecturers and classes starting late, and inability of the students to cope with the workload.

Conclusion:

The study revealed that the main reasons for the students’ absenteeism from scheduled learning experiences were related to the lecturers’ behaviour and practices. The poor lecturer-student relationship discouraged the students from attending classes.
Review of Research on Hydrostatic Bearings
Authors: Yu Xiaodong , Wang Yu , Wang Junfeng , Zhou Wenkai , Bi Hongwei , Wu Guangpeng , Gao Weicheng
Published: December 2020

Background:

Hydrostatic bearings possess the advantages of strong bearing capacity, good
stability, small friction coefficient, and long life. The performance of liquid hydrostatic bearings directly
affects the accuracy and efficiency of CNC machining equipment. The performance is conducive to the
development of CNC machine tools towards high speed and heavy load, so it is necessary to sort out and
summarize the existing research results.

Objective:

This study summarizes the current development status of hydrostatic bearings and explains the development
trend of hydrostatic bearings.

Methods:

According to the recently published journal articles and patents, the recent experimental research
on hydrostatic thrust bearings is summarized. This paper summarizes many factors that affect the
performance of hydrostatic bearings, and discusses the effect of various factors on hydrostatic bearings.
Finally, future research on hydrostatic bearings is also presented.

Results:

The study discusses experimental methods, simulation processes, and experimental results.

Conclusion:

Dynamic and static pressure effects can be produced by changing the structure of the oil
cavity of the hydrostatic bearing. This effect can make up for the static pressure loss. By improving the
theoretical formula and mathematical model and proposing a new simulation method, the accuracy of the
hydrostatic bearing simulation can be obtained; the future development trends of the hydrostatic bearing
have been proposed in this paper.
Development of a place for science communication as an initiative to support the construction of a novice ECEC practitioner's view of children
Authors: Inoue Chika
Published: December 2020

Children are born curious - they need to be in order to learn by listening and watching the adults in their life. Children learn by experience until they go to school. Beginning in preschool and becoming more rigid as they age, the school environment focuses on acquiring specific knowledge
in a standardised way. Chika Inoue is a Senior Lecturer at Aichi Shukutoku University, Faculty of Human Services Major of Child Care and Education, and is working alongside research collaborators to bring together ECEC practitioners, children and parents in order to understand how everyone
can be involved in creating a more informal learning environment.
Exploring algebraic structures of nonlocal classical integral systems
Authors: Tutiya Yohei
Published: December 2020

Mathematics underpins so many aspects of nature and society, from the mathematical array of natural structures to the use of statistics, fractions and mathematical models in everyday life. The application of mathematics to real life problems is vital, yet there are many examples of
failed attempts to apply mathematics to solve everyday issues that have arisen as a result of an underinvestment in and underdevelopment of the field of mathematics. One prominent example of this lack is non-linearity. Dr Yohei Tutiya, an Associate Professor from the Center for Basic Education
and Integrated Learning at Kanagawa Institute of Technology in Japan, has been exploring the classical integrable system in relation to the possibility of developing further non-local differential equations.
The Narrative Generation of Kabuki
Authors: Ogata Takashi
Published: December 2020

Japan has a long history of unique artistic expression which has created highly defined genres and styles. This formalisation and tradition have allowed Japan to be home to some of the oldest performing arts, the most famous being Noh and Kabuki. Kabuki, a form of dance-drama, is 400
years old and academics at Iwate Prefectural University are now examining the narrative structures underpinning Kabuki using novel AI techniques
Análise da qualidade de vida de pacientes portadores de dermatoses benignas em um hospital de ensino de Minas Gerais
Authors: Inácio Diego de Souza , Ottoboni Thaíssa Santos de Carvalho , Paula Tatiana Capistrano de , Ribeiro Thaissa Aline , Monteiro Silva Raissa , Brito Izabela Silva , Ribeiro Clarissa Santos de Carvalho
Published: December 2020

Objetivo: Analisar a qualidade de vida (QV) de pacientes portadores de dermatoses benignas em ambulatório de dermatologia de hospital de ensino do Sul de Minas Gerais. Métodos: Estudo quantitativo, transversal, do tipo pesquisa de campo e de perfil populacional e formas de promoção de saúde, no qual se fez a análise da QV de pacientes portadores de dermatoses benignas (psoríase, vitiligo, melasma, acne, dermatite e rosácea), de fevereiro a julho de 2017. Foram aplicados o Questionário Genérico de Qualidade de Vida - SF36 e o Dermatology Life Quality Index (DLQI-BRA), traduzidos e validados para a língua portuguesa. Resultados: Foram entrevistados 68 pacientes, dos quais 47 eram do sexo feminino (mín. 13; máx. 75 anos). No SF36, os domínios Limitação por Aspectos Emocionais (escore médio, EM, de 57,3) e Vitalidade (EM 58) foram os de pior resultado. No DLQI-BRA, o EM foi de 6,97, sendo Sintomas e Sentimentos (EM 2,69) e Atividades Diárias (EM 1,79) os de maior prejuízo para o doente. Não foram observadas correlações relevantes entre os diferentes domínios de cada questionário. Conclusão: Este estudo identificou piores escores nos Aspectos Emocionais e na Vitalidade do paciente no que diz respeito à QV de forma geral. Em relação à situação dermatológica foi pontuado escore geral de moderado efeito na QV dos pacientes. Os sintomas, sentimentos e as atividades diárias foram os fatores que causam maior prejuízo para o doente.
Avaliação da qualidade de vida e impacto na saúde bucal da pessoa com deficiência visual
Authors: Silva Neta Maria Eugenia da , Barbosa da Silva Maria das Graças , Catão Maria Helena Chaves de Vasconcelos
Published: December 2020

Objetivo: Avaliar a qualidade de vida (QV) e a percepção da saúde bucal de deficientes visuais. Métodos: Trata-se de um estudo quantitativo, de caráter transversal, abrangendo pessoas com deficiência visual, nos meses de setembro e novembro de 2019. Foram entrevistados 20 deficientes visuais no Instituto de Educação Assistencial aos Cegos do Nordeste, Campina Grande, Paraíba, Brasil, maiores de 18 anos. Para a avaliação da QV foi utilizado o World Health Organization Quality of Life (WHOQOL-Bref) e para avaliação da percepção de saúde bucal foi utilizado o Oral Health Impact, Profile (OHIP-14, versão em português).  Para a análise dos dados utilizou-se a estatística descritiva e categorização. Resultados: Observou-se uma predominância de indivíduos do sexo masculino (80%), com média de idade de 32,3 anos. Em relação à escolaridade, 40% possuíam o ensino médio completo. Sobre o estado civil, 75% eram solteiros. O estudo revelou melhor QV nos domínios psicológico e relações sociais (escores médios, EM: 4,0 ± 2,83 e 3,9 ± 3,22, respectivamente). Com relação à avaliação da percepção sobre a saúde bucal, as dimensões mais afetadas foram dor física (EM 2,05 ± 2,01) e desconforto psicológico (EM 2,25 ± 2,27). Conclusão: Pessoas com deficiência visual apresentam uma menor percepção de QV nos domínios físico e de meio ambiente e, no que tange à percepção de saúde bucal, os indivíduos pesquisados sentem-se insatisfeitos com a sua atual condição.
Children and adolescents’ health on focus: Gastrointestinal injuries associated with Helicobacter pylori
Authors: Bertolo Guariento Maria Rossana , Pereira da Silva Janine , Guariento Giovana Bertolo , Pinasco Gustavo Carreiro , Sales Arthur Brunelli , Alves Catarina Bubach Ribeiro , Pimassoni Lucia Helena Sagrillo , Ramos-Silva Valmin
Published: December 2020

Objective: To describe the prevalence of Helicobacter pylori (HP) in children and adolescents, and to assess its association with lesions in the esophagus, stomach, and duodenum according to the patient’s life cycle. Methodsː A cross-sectional analytical study with children and adolescents referred to a gastroenterology service and underwent esophagogastroduodenoscopy at a hospital in Vitória, Espírito Santo, Brazil, from 2001 to 2013. Variables analyzed were the following: sex, age, macro and microscopic alterations and severity of infestation. The Chi-square and Fisher's exact tests and adjusted residue analysis were used (α = 5%). Resultsː the prevalence of infection was 24.4%. Esophagitis (29.4%) and gastritis (34.1%) were associated with HP. The life cycle was associated with esophagitis and duodenitis. Infection was associated with life cycle: infants (0.8%), preschool children (10.5%), school-aged children (16.5%), and adolescents (72.2%). The residues showed a strong association between HP and gastritis, and no association between the school-aged and esophagitis. Adolescents were the major contributors to the association between life cycle and infection, and life cycle and lesion. Conclusionsː Infection with HP was associated with esophagitis and gastritis and was higher among adolescents, who had a marked tendency to develop gastritis and a milder tendency to develop esophagitis. The tendency of developing infection and gastritis was not present in the other life cycles. Public policies focusing on promotion and protecting health, especially in vulnerable population groups, are needed.
Anais do II Congresso Sul Mineiro de Anatomia Aplicada à Neurologia
Authors: II Congresso Sul Mineiro de Anatomia Aplicada à Neurologia
Published: December 2020

O II Congresso Sul Mineiro de Anatomia Aplicada à Neurologia foi realizado de maneira gratuita, com o objetivo de levar conhecimentos neuroanatômicos de base no âmbito clínico, cirúrgico, semiológico e radiológico para acadêmicos na área da saúde. O evento foi realizado de maneira online, possibilitando a união de conhecimento de diversas áreas. Foi organizado pela Faculdade de Medicina de Itajubá (FMIT), em conjunto com a Universidade de Alfenas (UNIFENAS), sendo realizado no dia 29, 30 e 31 de outubro de 2020. Website: https://www.even3.com.br/2csma/
Interferência do comportamento sedentário e da prática de atividade física nos indicativos de burnout de estudantes de educação física
Authors: Oliveira Daniel Vicentini de , Freire Gabriel Lucas Morais , Xavier Jeferson de Jesus Moura , Ribeiro Thiago Becegatto , Pimentel Helcimary Dalila Alves , Gouvêa José Alípio Garcia , Oliveira Leonardo Pestillo de , Nascimento Júnior José Roberto Andrade do
Published: December 2020

Objetivo: verificar se o comportamento sedentário e a duração e frequência da prática de atividades físicas interferem nos indicativos de burnout de estudantes universitários de educação física. Métodos: trata-se de um estudo transversal, realizado com 147 acadêmicos de educação física, bacharelado, de ambos os sexos. Foi utilizado uma adaptação para o contexto acadêmico (estudantes) do Cuestionario para la Evaluación del Síndrome de Quemarse por el Trabajo, e o Questionário Internacional de Atividade física (IPAQ – versão curta). Os dados foram analisados pelos testes Kolmogorov-Smirnov e “U” de Mann-Whitney e o nível de significância adotado foi de p < 0,05. Resultados: os estudantes que caminham até 40 min por dia apresentaram maiores sintomas de burnout do que os estudantes com maior tempo de caminhada no dia (p = 0,007). Os estudantes que caminham até 135 min semanais apresentaram maiores indicativos para desenvolvimento de desgaste psíquico do que os que caminham mais de 135 min semanais (p = 0,017). Os estudantes que praticam até 60 min de atividades moderadas por dia apresentaram escore superior aos estudantes que praticam mais de 60 min de atividades moderadas por dia (p = 0,011). Foram encontradas diferenças significativas nas dimensões de indolência (p = 0,011) e culpa (p = 0,023), evidenciando que os estudantes que passam mais tempo sentados apresentaram escore superior em ambas as dimensões de burnout. Conclusão: a duração e frequência da atividade física e o comportamento sedentário interferem nos indicativos de burnout em estudantes de educação física.
Development and Feasibility of a Digital Acceptance and Commitment Therapy–Based Intervention for Generalized Anxiety Disorder: Pilot Acceptability Study
Authors: Hemmings Nicola R , Kawadler Jamie M , Whatmough Rachel , Ponzo Sonia , Rossi Alessio , Morelli Davide , Bird Geoffrey , Plans David
Published: December 2020

Background

Generalized anxiety disorder (GAD) is characterized by excessive worry that is difficult to control and has high comorbidity with mood disorders including depression. Individuals experience long wait times for diagnosis and often face accessibility barriers to treatment. There is a need for a digital solution that is accessible and acceptable to those with GAD.

Objective

This paper aims to describe the development of a digital intervention prototype of acceptance and commitment therapy (ACT) for GAD that sits within an existing well-being app platform, BioBase. A pilot feasibility study evaluating acceptability and usability is conducted in a sample of adults with a diagnosis of GAD, self-referred to the study.

Methods

Phase 1 applied the person-based approach (creation of guiding principles, intervention design objectives, and the key intervention features). In Phase 2 participants received the app-based therapeutic and paired wearable for 2 weeks. Self-report questionnaires were obtained at baseline and posttreatment. The primary outcome was psychological flexibility (Acceptance and Action Questionnaire-II [AAQ-II]) as this is the aim of ACT. Mental well-being (Warwick-Edinburgh Mental Well-being Scale [WEMWBS]) and symptoms of anxiety (7-item Generalized Anxiety Disorder Assessment [GAD-7]) and depression (9-item Patient Health Questionnaire [PHQ-9]) were also assessed. Posttreatment usability was assessed via self-report measures (System Usability Scale [SUS]) in addition to interviews that further explored feasibility of the digital intervention in this sample.

Results

The app-based therapeutic was well received. Of 13 participants, 10 (77%) completed the treatment. Results show a high usability rating (83.5). Participants found the digital intervention to be relevant, useful, and helpful in managing their anxiety. Participants had lower anxiety (d=0.69) and depression (d=0.84) scores at exit, and these differences were significantly different from baseline (P=.03 and .008 for GAD-7 and PHQ-9, respectively). Participants had higher psychological flexibility and well-being scores at exit, although these were not significantly different from baseline (P=.11 and .55 for AAQ-II and WEMWBS, respectively).

Conclusions

This ACT prototype within BioBase is an acceptable and feasible digital intervention in reducing symptoms of anxiety and depression. This study suggests that this intervention warrants a larger feasibility study in adults with GAD.
Mapas Sociales Urbanos, Instrumento de Apropiación del Territorio y Visibilización de Problemas Ambientales
Authors: Diez Paula , Vazquez Miriam , Britos Adriana , Ruiz Sebastian
Published: December 2020

El trabajo presenta el Proyecto de Extensión “Colegios y Escuelas: un espacio en común para la construcción del conocimiento geográfico” que tiene como finalidad utilizar como estrategia didáctica la construcción del saber disciplinar a partir de la elaboración de cartografía. Los mapas persiguen un trabajo reflexivo de recopilación y tratamiento de información geográfica que permiten, la representación e interpelación del territorio actual y emiten un mensaje que provoca en el estudiante una serie de interrogantes que guían su aprendizaje. En este contexto la extensión universitaria consolida la democratización del saber y favorece la construcción de ciudadanía responsable del territorio que habita.
Dacha-estate topos “Russian Finland”: “White Night” of Leonid Andreev
Authors:   Uniwersytet Warszawski (Poland), Lutsevich Lyudmila F.
Published: December 2020

Based on the analysis of “documents of personal origin”, the article outlines some of the features of the dacha-estate topos “Russian Finland”. Attention is focused on the dacha-estate topos, “created” by a creative personality. Accordingly, it is con ceived not only as a realization of the concept of comfort for life and work, but also as an opportunity to express some kind of “topos of a dream”. The article is based on observations concerning Leonid Andreev’s dacha “White Night.”
Estate poetry at the turn of the XIX–XX centuries: transition to the post-estate period
Authors:   Ya. Kupala Grodno State University, Grinevich Olga A.
Published: December 2020

The transitional nature of the era of the turn of the XIX–XX centuries re flects in the structure of the “estate supertext” of Russian literature. From a seman tic point of view, the elegiac moods of longing and loss are intensifying, get actu alized the motives of old age, sunset, autumn, winter. The communicative structure of estate poetry is becoming more complicated, which reflects the internal polemic with the preceding tradition and the growing dialogism associated with many new artistic trends and trends that interpret the same topic in different ways. The status of the “estate topos” is being transformed: it begins to fulfill not only a spatial func tion, but also a rhetorical one (illustration of an idea, point of view, argumentation).
Poetosphere and mythopoetics of the estate in A.A. Blok’s dramatic poem “Song of Fate”
Authors:   A.M. Gorky Institute of World literature of the Russian Academy of Sciences, Kuznetsova Ekaterina V.
Published: December 2020

As it noted by the researchers, the “Song of fate” accumulates painful thoughts of A.A. Blok about the fate of Russia and about his personal fate associat ed with the past, present and future of the Motherland. In addition to the ideological problems raised in it, the poem is interesting in an attempt to escape from the specifics of historical and national-cultural realities through their symbolization, combining the plans of life and being. The white house with a garden on the hill, in which the action of the play begins and the return to which is implied at the end, incorporates the most important features of Russia as a cultural, natural and spiritual space. The world of the estate is opposed by the space of the modern city and the big world of Russian open spaces. However, the estate for Blok is Russia the same. Therefore, Elena, the keeper of the estate, and Faina, the personalization of the world element, are two parts of one whole, as if the projection of an ideal Russia. The plot of the “Song of fate”, accord ing to D.M. Magomedova, I.S. Prikhodko, etc., is an artistic realization of the Gnostic myth of the captive Sophia, the Soul of the world. The imposition of the Gnostic myth in the “Song of fate” on the entire existing in Russian literature of the XIX century poetosphere of the estate leads to the creation of the author’s myth about Russia, the transformation of poetosphere in the mythopoetics.
The “estate topos” in the works of representatives of the “peasant concord” group
Authors:   A.M. Gorky Institute of World literature of the Russian Academy of Sciences, Skorokhodov Maxim V.
Published: December 2020

“Estate topos” is usually considered in the works of authors who had estates or for a long time were living in estates of their relatives and friends. Significantly less attention is paid to the characterization of the “estate topos” in the texts of the authors, who, due to class restrictions, were not the owners of the estates and their frequent guests. In the literature of the Russian Silver Age, these are primarily the poets of the “peasant concord” group: N. Klyuev, S. Ese nin, A. Shiryaevets, S. Klychkov and oth- ers. For them, the most important and often the earliest in time of development of the source of knowledge about the Russian estate was Russian literature. The poets got an idea of estate complexes from personal experience. Elements of these complexes become symbols, each of which has a semantic filling formed over a long period. Revolutionary events of 1917–1921 lead to the rapid death of the estate world. If Klyuev in the early post-revolutionary years welcomed this process, then for Shiryaevets the Russian estate is inseparable from peasant life, Esenin is characterized by the transfer of elements of landlord complexes to the space of the peasant estate, in the heritage of Klychkov, like some other authors, an important role is played by a garden connected not only with the landowner estate, but also with peasant life, with the Garden of Eden.
“Appear gorgeous, quiet Osuga…”: originality of country “estate topos” in Dmitry Merezhkovsky’s play “Romantics”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Andrushchenko Elena A.
Published: December 2020

D.S. Merezhkovsky’s play “Romantics” (1917) rarely attracts a researcher’s interest, although it is a notable attempt to revisit the rich material on the family history of the Bakunins contained in A.A. Kornilov’s work “Mikhail Bakunin’s young years. From the history of Russian romanticism” (1915). Merezhkovsky’s “bookishness” in the play is apparent in the creation of the idyllic image of Pryamukhino, where he relied on Kornilov’s book and composed a stylization, in which he handled “someone else’s” text and “point of view”. The stylization is reflected in the “estate topos”, which acts as a decoration for the characters’ intellectual aspirations. Coupled with intertext and mythopoetics, it establishes a myth of the intelligentsia’s religious communality, which Merezhkovsky had been developing in his fiction and public writings of those years. These have common motives of paradise, sacrifice, celibacy, unconscious Christianity, duality, detachment. The properties of the “estate topos” in “Romantics” are such that, on the one hand, it is related to the source, while on the other hand each of its elements is integrated into a particular sequence identifiable by its purpose in “estate” literature. This purports to reflect the reality, but is actually the reflection of its reflection; it binds the events to a concrete time and space, yet also affirms the idea of a timeless, universal realization, which is in line with Merezhkovsky’s mythopoetic creative consciousness.
The structure and meaning of the “estate topos” in the A.N. Tolstoy’s story “Nikita’s Childhood”
Authors:   Academician S.P. Korolev Samara National Research University, Perepelkin Mikhail A.
Published: December 2020

The article investigates the structure and artistic function of the “estate topos” in the story of A. Tolstoy “Nikita’s Childhood”. First of all, is considered “The Case of the Samara provincial Council by the insurance Department on the adoption of the fear of the real property owned by the landowner Yakov Mironov and located near the village of Pavlovka (Sosnovka also), Vozdvyzhensky parish of the Nikolaev district of the Samara province” on the basis of which the con- clusion that was sold by the stepfather of the future writer A. Bostrom land owner J. Mironov real estate “near the village of Pavlovka (Sosnovka also)”, depicted by A. Tolstoy in the story “Nikita’s Childhood”. Further, the structure of the estate space in the story is studied and it is concluded that all the components of the estate topos — garden, ponds, cellars, barns, etc. — are in the process of non-stop metamorphoses that set in motion the entire estate as a whole; these metamorphoses constitute the real plot of the story. In conclusion, a fantastic hypothesis of the organization of the “estate topos” in “Nikita’s Childhood” is proposed, which brings this story closer to the works of A. Tolstoy in the genre of fiction and, above all, to the story “Aelita”.
The originality of the “estate topos” in the A.N. Tolstoy’s novel “Peter the First”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Akimova Anna S.
Published: December 2020

Moscow is the city which united the characters of A.N. Tolstoy’s novel “Peter the First”. Kitay-Gorod is the space where the action of the first book is mainly set. In the novel Tolstoy showed in great detail the everyday life of the city and its inhabi- tants. According to the I.E. Zabelin’s research (“History of the city of Moscow”) in late 17 — early 18 th centuries Moscow was like a big village that is why Tolstoy relied on his childhood memories about the life in the small village Sosnovka (Samara Region) describing the streets of Moscow. The novel begins with the description of a poor peasant household of Brovkin near Moscow, then Volkov’s noble estate is depicted and Menshikov’s house. The space of the city is expanding with each new “address”. Moscow estates, and in particular, connected with the figure of “guardian, lover of the Princess-ruler” V.V. Golitsyn, in Tolstoy’s novel are inextricably linked with the character’s living and with the life of the country. The description of the palace built by Golitsyn at the peak of his career is based on the Sergei Solovyov’s “History of Russia in ancient times”. Golitsyn left it and went to his estate outside Moscow Medvedkovo and from there in exile.
The “estate text” in the poetry of the Soviet “Sixtiers”: E.A. Evtushenko, A.A. Voznesensky, B.A. Akhmadulina
Authors:   Russian State University for the Humanities, Markov Alexander V.
Published: December 2020

The article discusses the reasons for referring to the estate text of the poets-“sixtiers”. It is proved that it could not be caused by simple historical interest, but was caused by the crisis of poetics, at the same time the exhaustion of its resources and the inability to embed another existential trial in the inherited resource of existential experience. Then the estate turns out to be a place of remembrance, where nature can be indistinguishable from culture, and in this indistinguishability a drift is possible from simple and routine forms of the “sixtiers” poetry to more complex ones. The specificity of the estate in the poetry of the three leading Russian poets of the sixties, Yevgeny Yevtushenko, Andrei Voznesensky and Bella Akhmadulina, is characterized, and it is shown that although the reasons for addressing the estate theme were different, the results, such as dialogue with tradition and updated author’s identity, a new reflection mode, turned out to be the same. This allows us to clarify literary estates as a resource not only of cultural memory in literature, but also of innovations in poetics or of those intermedial combinations and unexpected allusions that lead to innovations that are not limited to the thematic side.
Religious motifs of the comedy of Nikolai Gogol “The Gamblers”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Vinogradov Igor’ A.
Published: December 2020

The fundamental, plot-forming theme for Nikolai Gogol’s comedy «The Gamblers” (1842) is investigated, the idea that ignoring a secularised society of spiritual ideals, focusing only on «technical» improvement leads to the exhaustion of a credit of trust between people, without which the existence of any social institution is impossible. The originality of Nikolai Gogol’s plan lies in the fact that he managed to put an ordinary card game on a par with numerous phenomena of public life, in which, since the time of Peter I and Catherine II, «imaginative» values based on conditional recognition of their validity began to play a much bigger role, than in pre-Petrine Russia. The play is considered in the context of all the writer’s work; a connection is established between its content and «The Government Inspector” (1836), «Dead Souls» (1842), the book «Selected Passages from Correspondence with Friends» (1847), and other works by Nikolai Gogol.
Trinity list of memories schemamonk Selevkiy (Trofimov) about his travels in the orthodox east
Authors:   Moscow Theological Academy, Chasin Yevgeniy V.
Published: December 2020

“The story of Mount Athos schemamonk Selevkiy of himself, how he, having left the Balkan Mountains, wandered around Russia, Palestine, Athos”, written in the mid-19th century, is published for the first time on the Trinity list from the collections of the Russian State Library. The introductory article describes the distinctive features of this list in comparison with that of Mount Athos, describes the main stages in the life of the schemamonk Selevkiy (secular name — Stepan Trofimov). The memoirist sets out in detail the story of his journey to God, wandering in the holy places of Russia, Turkey, Palestine and Mount Athos. His observation was reflected in descriptions of temples, monasteries, numerous shrines, in sketches of meetings with different people; these include vivid and colourful images of representatives of different social strata of society: nobles, merchants, military men, simple monks and famous confessors, pilgrims and even robbers who would try to rob him and ruin his life. When describing the Mount Athos period of his life, Father Selevkiy opens the veil of the sacred life of the ascetics of the Holy Mountain, their spiritual exploits, mystical experience, traditions and customs of Mount Athos. The “Story” of the Schemamonk Selevkiy is of particular historical and cultural value, since much of what he had seen was not preserved to this day.
Additions to the attribution of archival documents of the Manuscripts Department of the Russian State Library
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Shcherbakova Marina I.
Published: December 2020

The issue of significance of attribution for establishing the history of the creation of handwritten documents is discussed in the article using the examples of a copy of the working note of Saint Theophan the Recluse «Reservations in the book “Orthodox Worshipers in Jerusalem” » (1858) from the archive of the Russian Saint Panteleimon Monastery; made by Andrey Murav’yov as a translation of the Greek letter of Archimandrite Joasaph (1851), rector of the Holy Lavra of Saint Sabbas in Palestine; letters from nun Leonida (worldly Yelizaveta Obukhova), the female treasurer of convent of Saints Boris and Gleb in the hamlet of Anosino, to Archbishop Leonid (worldly Lev Krasnopevkov) and to his elder sister Nun Leonida (worldly Yekaterina Ushakova); and also letters to Archbishop Leonid from the two clerics both named Nafanail — Archimandrite Nafanail (worldly Gavriil Nektarov) and Archbishop Nafanail (worldly Nikolay Savchenko). Amendments, clarifications and important additions are made to the existing attribution of these documents based on the results of the investigations undertaken. Various methods of attribution — an analysis of the content of the source, of its culturally historical features, stylistic features, references to historical events, to the realities of life, to famous people — are demonstrated. The close association of attribution with the dating of the archive document, which in many cases helps to establish both the author and the addressee of the source, is revealed. The practical demand for attribution results is convincingly reasoned.
A criminalização do aborto na sociedade brasileira
Authors: Carvalho Larissa Landim , Curado Maria Eugênia , Pinheiro Veralúcia
Published: December 2020

Neste artigo, discutimos a criminalização do aborto na sociedade brasileira, instigadas pelo documentário Clandestinas. Nele, por meio da interpretação de atrizes, são contadas histórias de mulheres que realizaram aborto por diferentes motivos. Sua produção se deu a partir da compilação dos depoimentos de mulheres de diferentes lugares, raças e classes sociais, as quais contam suas experiências com a prática do aborto, deixando evidente as desigualdades quanto ao tratamento recebido no processo de enfrentamento de um fenômeno comum a todas elas. Nosso propósito é discutir o caráter violento que essa criminalização expressa, recorrendo ao conceito de violência simbólica de Pierre Bourdieu e nos valendo de dados disponibilizados por pesquisadores brasileiros que se debruçaram frente ao esforço de compreender peculiaridades de nossa sociedade em relação a questão do aborto.
Sustentabilidade
Authors: De Melo Peixoto João Guilherme , Lins Anthony José da Cunha Carneiro , Araujo Ribeiro Mariana de
Published: December 2020

Este artigo tem como objetivo verificar a adoção de práticas sustentáveis em marcas pernambucanas de moda. Para isso, foram analisados perfis no Instagram de três marcas: Marie Mercié, Refazenda e Viva Yemanjah como empresas que adotam práticas sustentáveis na produção de suas peças, buscando reduzir danos ao meio ambiente. Também foi realizada a revisão bibliográfica de conceitos de consumo sustentável, consumo consciente, branding ligado ao empreendedorismo, estratégias de marketing digital e consumo de ativismo.
Minoxidil and I (eye), just a coincidence or is it fate?
Authors: bozorgi ali , Khodabande Alireza , hosseini kaveh
Published: December 2020

A 39 years old healthy cardiologist with history of two months applying
of topical Minoxidil for androgenic alopecia was presented with
metamorphopsia and central scotoma. After full medical work-up, CSC was
diagnosed. Minoxidil may be the culprit for CSC.
Multiple meanings of resilience: Health professionals’ experiences of a dual element training intervention designed to help them prepare for coping with error.
Authors: Janes Gillian , Harrison Reema , Johnson Judith , Simms-Ellis Ruth , Mills Tom , Lawton Rebecca
Published: December 2020

Rationale, aims and objectives: Consistent data demonstrates negative
psychological effects of caregiving on front-line health professionals.
Evidence that psychological resilience factors can help minimise
distress and the potential for low-cost interventions have created
interest in resilience-based development programmes; yet evidence of
perceived value amongst health professionals is lacking. This study
explored health professionals’ experiences and perceptions of a novel,
resilience-based intervention designed to pro-actively prepare staff for
coping with error; to investigate their perceptions of what resilience
meant to them, the relevance of the intervention, and impact of
participation on ability to cope with error. Method: Semi-structured
interviews 4-6 weeks post intervention with 23 randomly selected
participants from seven cohorts (midwives, paediatricians,
obstetrians/gynaecologists, paramedics) and trainees (physician
associates, mammographers, sonographers). Thematic analysis of interview
data. Findings: Participants reported various interpretations of, and a
shift in perception regarding what the concept of psychological
resilience meant to them and their practice. These included for example,
resilience as a positive or negative concept and their awareness and
response to a range of personal, organisational and system factors
influencing personal resilience. They valued the prophylactic,
clinically relevant, interactive and applied nature of the intervention;
having developed and applied valuable skills beyond the context of
involvement in error, noting that individuals needed to be willing to
explore their own coping mechanisms and human fallibility to gain
maximum benefit. There was also consensus that whilst proactively
developing individual level psychological resilience is important, so
too is addressing the organisational and system factors that affect
staff resilience which are outside individual staff control. Conclusion:
Enhancing resilience appears to be considered useful in supporting staff
to prepare for coping with error and the wider emotional burden of
clinical work, but such interventions require integration into wider
system approaches to reduce the burden of clinical work for health
professionals.