bluuebunny/crossref_metadata_2025 huggingface dataset:
Sulfated galactan from Acanthophora muscoides inhibits adipogenesis via regulating adipogenic transcription factors and AMPK in 3T3-L1 cells
Authors: Silva A. V. L. , Lima R. P. , Oliveira F. T. B. , Quinderé A. L. G. , Benevides N. M. B. , Santos F. A.
Published: February 2025

Abstract Obesity is a global public health issue, closely linked to cardiovascular disease and type 2 diabetes. Pharmacological interventions for weight loss are one option for treating obesity; however, these drugs often come with side effects or limited efficacy, highlighting the need for new therapies. Marine algae offer a promising source of biologically active compounds for human health, including antidiabetic, anti-inflammatory, and anti-obesity properties. Sulfated galactan isolated from the red marine algae Acanthophora muscoides (SGAM) has demonstrated diverse biological activities including anti-inflammatory activity in vivo and in vitro studies. However, its potential impact on adipogenesis remains unexplored. This study evaluated the effect of SGAM on adipogenesis in 3T3-L1 cells using Oil Red O staining and analyzed the protein expression of key transcription factors associated with adipogenesis. SGAM (25−100 μg/mL) was found to reduce intracellular lipid accumulation in adipocytes without compromising cell viability. Furthermore, our findings suggest that SGAM significantly inhibits adipocyte differentiation by downregulating the expression of key adipogenesis-related transcription factors, including C/EBPβ, C/EBPδ, C/EBPα, and PPARγ. Additionally, SGAM reduced the protein expression of SREBP-1 and promoted the activation of AMPK. In conclusion, SGAM inhibits adipogenesis by negatively modulating the expression of the main adipogenic transcription factors and activating AMPK.
DETERMINAÇÃO DO RATICIDA WARFARIN POR ESPECTROFOTOMETRIA ULTRAVIOLETA
Authors: Almeida J. B. , Savoy Vera L. T. , Higashi Chizuko
Published: February 2025

RESUMO No presente trabalho é descrita técnica de determinação de formulação do raticida warfarin por espctrofotometria ultravioleta. Este método é baseado na transformação do warfarin em sal sódico. A técnica desenvolvida emprega operações mais simples do que os métodos já descritos, porém, é exata e precisa. A especificidade é obtida pela varredura total do espectro.
ESTABILIDADE DE AMOSTRAS CONGELADAS E LIOFILIZADAS DE LISADO DE CÉLULAS DA LINHAGEM SUÍNA IB-RS-2
Authors: Bersano Josete G. , Koseki Ignez , Abuhab Tauba G. , Rodrigues F.M. , Farinha F.B.N.
Published: February 2025

RESUMO Neste trabalho, comparou-se a capacidade de proteção conferida a suínos por amostras de lisado celular congeladas e por amostras congeladas e liofilizadas, quando desafiados com o vírus da peste suína clássica. As primeiras amostras conferiram proteção, quando estocadas por um período de até nove meses e, as últimas, quando estocadas por um período de até vinte e três meses, dependendo das concentrações do estabilizador e do inóculo.
DETERMINAÇÃO DE DODECACLORO EM ISCAS FORMICIDAS
Authors: Piedade Maria F. , Piedade J. R.
Published: February 2025

RESUMO Com o nome comum de dodecacloro se designa o composto químico definido como dodecaclorooctaidro-1,3,4-meteno-2H-ciclobutapentaleno. Este produto é um importante formicida utilizado no Brasil para o combate à saúva e, em outros países, contra outros tipos de formigas. Este trabalho descreve um método de análise para a determinação de dodecacloro em iscas formicidas.
MELHORAMENTO DO TRIGO: AVALIACÄO DE LINHAGENS MEXICANAS NO ESTADO DE sÄo PAULO
Authors: Camargo C. E. O. , Felício J. C. , Barros B. C. , Ferreira Filho A. W. P. , Freitas J. G. , Santos R. R. , Pettinelli Júnior A.
Published: February 2025

RESUMO Vinte e duas linhagens mexicanas e trés cultivares de trigo foram analisadas, quanto ås caracterfsticas agronömicas e a reagäo ås principais doeneas, em condigöes de inigääo, por aspersäo e, de sequeiro, em vårios locais do Estado. Em laboratörios foram realizados estudos da toleråncia ao alumfnio, em solüöes nutritivas, e em casa de vegetagäo avaliou-se a reacäo a misturas de ragas de Puccinia graminis tritici e de P. recondita. Nos experimentos conduzidos em condiqöes de irrigaqäo destacaram-se quanto produgäo de gräos as linhagens IAC 204 e IAC 246. A linhagem IAC 248 exibiu a maior produqäo de gräos nos ensaios instalados em condigäo de sequeiro, no Vale do Paranapanema. Considerando todos os experimentos em conjunto as linhagens IAC 248, IAC 246 e IAC 204 foram as que apresentaram maior produtividade. As linhagens Dove' 'S" - TSI (T-2), Maya"S" - MON"S" (T-3), (T-7), [(BB- CNO 67 x Cl 12703) PHO"S"] JUN"S" (T-9), (H. 285.70 - TOB x Yrs - MJ 692/PVN' 'S KAL - BB x ALD' 'S" (T-IO), IAC-246, IAC-206, IAC-207 , PEG' 'S" - PF 70354 (KAL - BB x (T-16), IAS-63- ALD"S" x GTO/LV (T-18), TOB"S"/CNO 67 - JAR x KVZ/Yaco"S" (T-20) e Maya - MON' ' S ' ' (T-21 ) bem como os cultivares Alondra-S-46 e Anahuac foram resistentes äs duas misturas de ragas prevalentes do agente causal da ferrugem-do-colmo em condigöes de casa de vegetaqäo. Estes gen6tipos também apresentaram-se como resistentes em condigöes de campo. As linhagens Dove' 'S ' ' - TSI (T-2) e IAC-207 foram resistentes a trés misturas de ragas prevalentes do agente causal da ferrugem-da-folha em condigöes de casa de vegetagäo confirmando a resisténcia mostrada em condigöes de campo. As linhagens (YD' 'S" x KAL - BB) HORK"S" - MO (T-4) e Mirio' 'S" - BUC"S" (T12) foram as mais resistentes ao ofdio em condigöes naturais de infecgäo. O cultivar IAC- 18 e as linhagens NAC - MON' 'S" (T-5) e (H.285.70 - TOB x rrs -W 692/PVN"S") - BB x ALD"S" (T-10) mostraram plantas de porte alto diferindo das demais que exibiram porte semi-anäo. As linhagens NAC - MON "S" (T-5) e IAC-248 mostraram as espigas mais compridas, IAC-207 maior nümero de espiguetas por espiga, [(BB - CNO 67 x CI 12703) PHO' ' S ' JUN' 'S" (T-9) maior nümero de gräos por espiga, IAC-203 maior nümero de gräos por espiguetae { [PJ x CNO 67 - 7C (CNO 67 - INIA x BB) VAR PCI' MRNG) ALD"S" x YR - TRF (T-17) os gräos mais pesados. O cultivar IAC-18 e as linhagens IAC-203, (YD"S" x KAL - BB) HORK"S" - MO (T-4), IAC-246, IAC-248 e ( [PJ x CNO 67 - 7C (CNO 67 - INIA x BB) VAR PCI"S"] MRNG} ALD"S" x YR - TRF (T-17) foram os mais tolerantes toxicidade de A13 +.
COMPORTAMENTO DE CLONES DE SERINGUEIRA (HEVEA BRASILIENSIS MUELL. Arg.) FRENTE A UMA ANOMALIA DE CASCA, NO ESTADO DE SÃO PAULO
Authors: Furtado E.L. , Menten J.O.M. , Costa J D. , Castro R.M.
Published: February 2025

RESUMO Em julho de 1988, foi observado no campo de competição de clones de seringueira da ESALQ/USP, a ocorrência de plantas, com oito meses de idade, com anomalias de casca, como: cancros de tamanhos variados, fendilhmentos longitudinais, com ou sem escorrimento de látex, e escamamento superficial. Localizadas, principalmente, nas regiões de fluxo foliar, na porção mediana do tronco que comprometiam o desenvolvimento das plantas. Avaliações efetuadas, da incidência e da severidade, demonstraram que dos 10 clones em competição, os mais suscetíveis foram o RRIM 526 e o PB 252. Dos isolamentos efetuados, em laboratório, constatou-se os fungos Botryodiplodia theobromae e Phomopsis SP. associados às lesões.
SURTO DE TUBERCULOSEEMCRIAÇÃODECHINCHILAS (CHINCHILLA LANÍGERA)
Authors: Portugal M.A.S.C. , Calili Ercília M.B. , Farinha F.B.N. , Guerra J.L.
Published: February 2025

RESUMO Em um surto de tuberculose ocorrido em criação de chinchilas, os autores abordam aspectos relacionados com a sintomatologia, achados bacteriológicos e lesões macro e microscópicas observadas, além dos resultados obtidos na prova comparativa de tuberculinização, utilizando-se PPDs de origem mamífera e aviária. Os resultados mostraram tratar-se de bacilo de origem mamífera, sendo considerada como fonte de infecção um dos tratadores que era portador de tuberculose pulmonar. Face à extensão e gravidade do surto e ao estado geral dos animais não se recomendou qualquer tipo de tratamento, tendo-se optado pelo sacrifício do plantel remanescente.
ASPECTOS BIOLÓGICOS E COMPORTAMENTAIS DA TRAÇA DO TOMATEIRO SCROBIPALPULA ABSOLUTA (MEYRICK, 1917), (LEPIDOPTERA-GELECHIIDAE)
Authors: Imenes Silvia D.L. , Fernandes Manoel A. Uchôa , Campos Tércio B. de , Takematsu Akira P.
Published: February 2025

RESUMO Com o objetivo de contribuir para o desenvolvimento de novos métodos de controle e a efetivação de criações massais da traça Scrobipalpula absoluta (MEYRICK, 1917), cujas larvas minam folhas, frutos e brotações novas do tomateiro, efetuou-se em laboratório, a biologia comparada entre 38 casais alimentados com solução de mel a 10% e 38 recebendo apenas água. Os resultados apresentados refletem a média dos dados obtidos para casais alimentados e não alimentados, respectivamente. Número de acasalamentos: 10,4 e 2,9; período de oviposição: 25 ,3 e 8,5 dias; número de posturas / : 20,7 e 7 ,8; total de ovos / : 261 ,7 e 147 , 7; número máximo de ovos/postura: 69 e 57 pico de postura entre o | .0 e 2.0 dia: 92,0 e 81 ,6% das fêmeas; início das atividades de acasalamento para os dois tratamentos: ± 7 horas; duração do acasalamento: 4h, 32m e 4h, 49min.; porcentual dos ovos obtidos na I .a semana: 76 e 95%; longevidade do d : 36,8 e 10,0 dias; longevidade da : 31 ,4 e 12,5 dias; viabilidade dos ovos: 88, 0 e 76,0% ; período de incubação: 5,1 e 5,9 dias; viabilidade larval 68,4 e 71 ,2%; período larval: 19,3 e 19,4 dias. Para os descendentes de casais alimentados observou-se viabilidade pupal: 92,1 período pupal: 10,8 dias (3) e 9,6 dias (9); razão sexual = 0,61.
ESTABILIDADE DE FORMULACÖES DE BACULOVIRUS ANTICARSIA OLEO EMULSIONAVEL E PÓ MOLHÁVEL EM CONDIÇÕES DE LABORATÓRIO
Authors: Batista Filho A. , Alves S.B. , Augusto N.T. , Cruz B.P.B.
Published: February 2025

RESUMO Estudou-se a estabilidade de Baculovirus anticarsia, em condiqöes de meio ambiente, quando preparado nas formas de p6 molhåvel-PM (talco) e de 61eo emulsionåvel-OE (61eo de soja + emulsificante). Foram comparados o pat6geno formulado, virus purificado e uma testemunha. Esses materiais foram acondicionados em frascos de vidro com capacidade de 8,0ml, vedados com tampa plåstica e armazenados em armårio de madeira, abrigados da luz. Os testes de viabilidade do pat6geno foram realizados imediatamente ap6s a preparaqäo das formulaqöes e ap6s 12 meses de armazenamento. O pat6geno formulado como p6 molhåvel (talco) näo apresentou queda significativa de atividade, ao longo dos 12 meses, enquanto que a formulaqäo em 61eo vegetal perdeu mais de 50% de viabilidade.
INTERAÇÃO DO VÍRUS DA NECROSE BRANCA DO TOMATEIRO (VNBT) COM DOIS OUTROS VÍRUS QUE AFETAM O TOMATEIRO: MOSAICO DO FUMO (TMV) E VIRA-CABEÇA (TSWV)
Authors: Colariccio A. , Barradas M.M. , Vicente M.
Published: February 2025

RESUMO Tomateiros cv. Santa Cruz foram inoculados com o VNBT e, simultaneamente ou 24 horas após, também com o TMV ou o TSWV. As plantas duplamente infectadas com o VNBT e o TMV apresentaram reação sinérgica, não só quanto à sintomatologia foliar como também com relação à altura das plantas, ao peso fresco e ao peso seco da parte aérea. Na infecção simultânea induzida por VNBT + TSWV, houve efeito aditivo. Porém, quando o intervalo entre as inoculações foi de 24 horas, o efeito variou, de acordo com a ordem de inoculação, havendo morte das plantas, quando o TSWV foi inoculado antes, e um desenvolvimento das plantas semelhante ao do controle, quando o VNBT foi o primeiro vírus inoculado, sugerindo um certo efeito protetor desse vírus. Na discussão, levanta-se a possibilidade de a morte das plantas de tomate ser mais rápida quando ocorrerem infecções múltiplas do VNBI' com TMV ou TSWV do que quando as infecções forem isoladas.
DETERMINAÇÃO DO MANGANÊS EM FUNGICIDAS POR COMPLEXOMETRIA POTENCIOMÉTRICA
Authors: Almeida J. B. de , Savoy V. L. T.
Published: February 2025

RESUMO No presente trabalho é descrita a técnica analítica para determinar quantitativamente o manganês no maneb e no mancozeb pelo método de complexação potenciométrica empregando-se a voltametria (potenciometria por corrente constante). No mancozeb é necessária a separação do zinco, na forma de zincato, antes de se processar a análise do manganês. Essa técnica analítica apresentou grande precisão em seus resultados e facilidade na sua execução.
OCORRÊNCIA DE BEAUVERIA AMORPHA (HÕHN) SOBRE ADULTOS DE COSMOPOLITES SORDIDUS GERMAR, 1824 (COL: CURCULIONIDAE) EM MIRACATU, ESTADO DE SÃO PAULO
Authors: Batista Filho A. , Leite L.G. , Prada W.L.A. , Raga A. , Sato M.E. , Alves S.B.
Published: February 2025

RESUMO A ocorrência de Beauveria amorpha (Hóhn) sobre adultos de Cosmopolites sordidus Germar, foi observada em Miracatu, São Paulo. Os maiores índices de infecção foram observados nos meses de novembro (29,0%), dezembro (21,0%) e janeiro (31,5%).
CAPACIDADE REPRODUTIVA DE MUSCIDIFURAX UNIRAPTOR KOGAN & LEGNER (HYMENOPTERA: PTEROMALIDAE) EM PUPAS REFRIGERADAS DE MUSCA DOMESTICA L. (DIPTERA: MUSCIDAE)
Authors: Thomazini M.J. , Berti Filho E.
Published: February 2025

RESUMO Lotes de pupas de mosca-doméstica com dois e três dias de idade foram armazenados em geladeira (7 a 10ºC) por um a cinco dias, para verificar a influência desse processo na capacidade reprodutiva de Muscidifurax uniraptor Kogan & Legner (Hymenoptera: Pteromalidae). Após 24h em contato com as pupas (25 ± 1ºC, 70 ± 10% U.R., fotofase de 14 h), os parasitóides foram retirados. A mortalidade de pupas e a emergência de descendentes foram avaliadas após 30 dias. Desse modo, a refrigeração do hospedeiro não afetou a capacidade reprodutiva do parasitóide quando foram utilizadas pupas com três dias de idade. Pupas com dois dias de idade, armazenadas em geladeira por três, quatro ou cinco dias e as não armazenadas, foram tão adequadas quanto as pupas com três dias de idade para a reprodução de M uniraptor.
AVALIAÇÃO CLÍNICA E BACTERIOLÓGICA DAS ENDOMETRITES PUERPERAIS E PÓS-PUERPERAIS DE VACAS LEITEIRAS
Authors: Margatho L.F.F. , Calil E.M.B. , Moulin A.A.P.
Published: February 2025

RESUMO Foram realizados exames clínicos e bacteriológicos no aparelho genital de 183 vacas leiteiras com sintomas clínicos de endometrites, em dois períodos, durante e após o puerpério, em 15 propriedades rurais na região de Bauru, Estado de São Paulo. As endometrites de l º grau foram predominantes sobre as demais, para uma freqüência de 63 (55,3%) animais no puerpério e 83 (79,8%) no pós-puerpério (P<0,0009). Os principais microrganismos isolados e identificados como causadores de infecções endometriais foram: Escherichia coli 69 (39,7%), Staphylococcus spp. 30 (l 7,3%), Streptococcus spp. 28 (16,l %) e Corynebacterium spp. 8 (4,6%), apresentando-se tanto em cultura pura como em associação. Em 35 (29,0%) casos de endometrite clínica, as culturas apresentaram-se estéreis. A Escherichia coli foi o microrganismo isolado com maior freqüência em ambos os grupos, sendo 37 (32,4%) no puerpério e 32 (30,8%) no póspuerpério. Houve maior número de casos de isolamento de Streptococcus spp. e Staphylococcus spp. no período pós-puerperal (P=0,0009). O Streptococcus spp. eram mais freqüentes em maior número de casos 22 (20,4%) nas endometrites do primeiro grau e o Corynebacterium spp. 4 (10,3%) nas do segundo grau (P=0,5819).
El desmoronamiento de las naciones
Authors: Kohr Leopold
Published: February 2025

What is true for men living in overcrowded prisons is also true for men living in the vast facilities of those modern nations whose undeniable size has become the cause of present difficulties.

Consequently, just as in the case of Korean prisoner-of-war camps, the solution to the problems facing the world as a whole does not seem to lie in the creation of larger social units or even broader governments—whose formation is set in motion by our statesmen with an uncreative fanaticism—but rather in the dismantling of those overdeveloped entities known as great powers and in the restoration of a healthy system of small, manageable states, which characterized bygone eras.

This is the proposal developed in this book, and I have no doubt that many will call it contrary to all our concepts of progress; which, of course, is true. The only thing I can do is respond with Professor Frank Tannenbaum of Columbia University: “Let them, let others have the slogans. Let them surpass themselves off the face of the earth, and then you will have infinite progress.”
Peripheral compound odontoma: A rare case report
Authors: Peranovic V , Bunn BK , Gwengu P
Published: February 2025

Odontomas are currently classified as benign mixed epithelial/mesenchymal odontogenic neoplasms which are located within the tooth-bearing regions of the jaws. Despite being considered neoplasms, the clinical characteristics of these lesions are much the same as hamartomatous lesions. Peripheral odontomas are rare entities that are located entirely within the adjacent soft tissue of the mucosa and/or gingiva. Apart from location, peripheral odontomas are morphologically, radiologically and pathologically indistinguishable from their intraosseous counterparts.
Preliminary Study of the Structure of Western Kansas
Authors: Lee Wallace , Merriam Daniel F.
Published: February 2025

Structure maps of the Stone Corral and Dakota formations show regional dip toward the north but are discordant in many respects. The thickness map of the interval between them reveals the structure of the Stone Corral when the Dakota was still undisturbed. The difference between the structure of the Stone Corral and the Dakota is due to the fact that the structure of the Stone Corral was already well defined before the development of conflicting post-Dakota deformation. The Stone Corral-Dakota thickness map shows that at the end of Dakota time, the structure of the Stone Corral formation conformed to the pattern of deformation that produced the Hugoton embayment of the Anadarko basin. This thickness map also reveals that there was, at the end of Dakota time, a northerly trending anticline (Oakley anticline) with structural relief of more than 200 feet at the top of the Stone Corral. Arching of the Central Kansas uplift was inactive after Stone Corral time and probably for some time before, but secondary structures continued to develop on its crest even after Dakota time. Except as reflected by the western limb of the Hugoton embayment, the northeasterly dip on the flank of the Las Animas arch was accentuated in Kansas after Dakota time and was in the main a postCretaceous structural feature in Kansas.
Post-Dakota deformation resulted in a generally northerly dip of the rocks of the region and introduced new regional structural features. These movements reinforced some of the older regional features, modified all in varying degree, and destroyed some broad pre-Cretaceous structural features at the horizon of the Stone Corral. The Oakley anticline was cancelled out at this horizon by a post-Dakota syncline, and the steeper anticlinal structure of the Oakley anticline in older rocks was modified but not destroyed. In a large part of the area east of the Las Animas arch, the low post-Dakota northerly dip did not materially alter the relation of anticlines at the horizon of the Stone Corral to the steeper structures of the older rocks.
A thickness map and cross sections of the Morrison formation reveal topographic relief at its top and bottom and suggest a low dip toward the Denver basin at the close of Morrison deposition. A thickness map of the interval between the base of the Cretaceous and the top of the Dakota reveals pre-Cretaceous topographic relief of more than 400 feet. An east-west cross section shows the bifurcation of the Stone Corral in southwestern Kansas. A north-south cross section shows that post-Permian movements tilted the Stone Corral formation toward the north but failed to overcome the original southerly dip of deeper beds whose dip was reduced by the amount of the post-Dakota northerly dip.
A INFLUÊNCIA DO TREINAMENTO DE CONSCIÊNCIA CORPORAL NO DESENVOLVIMENTO MUSCULAR
Authors: Removicz Natan Wesley , Vidal Rafael Gemin , Portela Andrey
Published: February 2025

O objetivo dessa pesquisa foi descrever a influência de sessões de treinamento de consciência corporal no desenvolvimento hipertrófico muscular localizado de praticantes de musculação. Trata-se de uma pesquisa aplicada, de campo, quantitativa, descritiva, onde foram selecionados sujeitos praticantes de musculação, com no mínimo um ano de experiência prática frequente e sistematizada, e que só praticassem essa modalidade. A amostra do tipo não probabilística intencional contou com 07 indivíduos de uma academia localizada na cidade de São Mateus do Sul - PR, de ambos os sexos, com idades a partir de 18 anos, em perfeito estado de saúde, e que tinham como objetivo de treino a hipertrofia e definição muscular esquelética. Todos apresentavam algum tipo de assimetria muscular. Como instrumento de coleta foi utilizado um inventário desenvolvido pelos pesquisadores especificamente para este estudo, que foi avaliado quanto a sua validade e clareza por três professores de Educação Física com experiência em pesquisa, alcançando os conceitos máximos. Para a realização do estudo, primeiramente este foi aprovado pelo Núcleo de Ética e Bioética da Uniguaçu, seguido de convite aos sujeitos para participarem, sendo familiarizados com os objetivos da pesquisa e com os instrumentos utilizados, assinando um termo de consentimento livre e esclarecido. A coleta respeitou os seguintes procedimentos: Aplicação do inventário; Período de treinamento da consciência corporal, juntamente com o treinamento de musculação, durante quatro semanas; Reaplicação do inventário. Os dados coletados foram analisados a partir da estatística descritiva utilizando o software Microsoft Excel. Ao final podemos considerar que o treinamento de consciência corporal proporcionou o desenvolvimento da hipertrofia e/ou da definição muscular em praticamente todos os participantes, tendo maior destaque em sujeitos com menor tempo de experiência com o treinamento resistido.
DES foodcrust protein extraction protocol v1
Authors: Dekker Joannes , Ramsøe Max
Published: February 2025

This protocol is an adaptation of the DES protocol developed by Manasji Chowdhury for the extraction of proteins from ceramic. This version has been designed for the extraction of proteins from foodcrust. The protocol consists of protein extraction from foodcrusts by incubating in a GuHCl and urea DES mixture, followed by reduction and alkylation, C18 StageTip desalting, sequential enzymatic digestion using trypsin and chymotrypsin. Lastly, the samples are cleaned up with Evotips in order to prepare them for loading on a Evosep LC system coupled to a mass spectrometer.
Protocol: RNeasy Plant Mini Kit for RNA Extraction v1
Authors: Villarino Gonzalo
Published: February 2025

This protocol describes the RNA extraction process from cannabis flowers using the Qiagen RNeasy Plant Mini Kit. Given the lack of a standardized RNA extraction method for cannabis, this protocol provides optimized steps to ensure high RNA yield and integrity by minimizing degradation. The workflow includes sample collection in the greenhouse (GH), flash-freezing in liquid nitrogen (LN2), mechanical disruption, and column-based RNA purification. Pre-warmed RNase-free water at 37°C is used to maximize RNA elution efficiency.
IMPLEMENTASI LAYANAN BK DALAM MENINGKATKAN PERKEMBANGAN SOSIAL-EMOSIONAL ANAK USIA DINI
Authors: Ayu Inka
Published: February 2025

The research investigates how counselling helps young children’s social-emotional development. Young children experience many social and emotional interactions that shape their future character and abilities. Counseling guidance is essential to help children develop good social skills, build positive relationships, and manage their emotions. One of the teachers of PAUD Aisyiyyah Pabelan was directly observed and thoroughly interviewed in this study, which used a qualitative approach. The result show that this kind of programme can be implemented in various early chilhood education institutions.
MENINGKATKAN KREATIVITAS ANAK DENGAN KEGIATAN ORIGAMI PADA KELOMPOK B USIA 5-6 TAHUN TINGKAT TK
Authors: Munavinahar Lailatul , Madoni Ely Roy
Published: February 2025

Kemampuan kreativitas anak sangat berkaitan dengan kegiatan pengembangan motorik anak, serta dapat mencakup banyak aspek yang ditingkatkan, seperti aspek kognitif, sosial emosional, bahasa, dan seni. Pada penelitian yang dilakukan peneliti di TK Kecamatan Kabuh dengan metode PTK (Penelitian Tindakan Kelas). Analisis bertujuan untuk dapat mengetahui meningkatnya kreativitas anak dengan kegiatan origami pada usia 5-6 Tahun di Kelompok B semester I. Perbaikan dilakukan dengan dua siklus, pada satu siklus terdapat lima pertemuan atau lima Rencana Pelaksanaan Pembelajaran. Perbaikan pada siklus terdiri dalam 4 tahap, yaitu rencana perencanaan, pelaksanaan kegiatan, pengamatan, dan hasil refleksi. Penelitian bersubyek pada anak usia 5-6 Tahun dengan jumlah 22 anak. Teknik pengumpulan data menggunakan instrument observasi dan dokumentasi. Metode penelitian yang dterapkan adalah metode deskriptif kuantitatif. Penelitian ini memperoleh hasil meningkatnya kreativitas anak dengan menggunakan kegiatan origami yang diterapkan, menghasilkan peningkatan pada setiap perkembangan masing-masing siklus, dengan rata-rata pada pra siklus kreativitas anak 32%, siklus I 59%, dan siklus II 77,2%.
MEDIA NUMBER RODS TERHADAP KEMAMPUAN BERHITUNG PADA ANAK KELOMPOK A
Authors: Agustini An nisa 'A , Sartika Indah Dwi , Astuti Mardiah , Cindrya Elsa
Published: February 2025

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh media number rods terhadap kemampuan berhitung pada anak kelompok A. Tujuan penggunaan media benda konkret khususnya media number rods dalam menstimulasi kemampuan berhitung pada anak kelompok A seperti pengoperasi penambahan, konsep bilangan, konsep pembagian, berfikir logis serta memecahkan masalah. Metode yang digunakan dalam penelitian ini adalah kuantitatif dengan jenis eksperimen dengan one group pretest posttest design. Pada penelitian ini sampel berjumlah 10 anak dengan menggunakan Teknik Purposive Sampling Pengumpulan data pada penelitian ini yaitu dengan menggunakan observasi, test, dan dokumentasi. Test dalam penelitian ini berupa pretest dan posttest dengan menggunakan Lembar Kerja Peserta Didik (LKPD) yang mengacu pada instrumen penilaian. Teknik analisis data pada penelitian ini uji validitas, uji reliabilitas, uji normalitas, uji homogenitas, dan uji hipotesis dengan menggunakan SPSS versi 26. Setelah itu untuk menguji pengaruh antara variabel bebas yakni media number rods terhadap variabel terikat yakni kemampuan berhitung menggunakan uji T. Dari hasil penelitian dan analisis data dapat ditarik kesimpulan bahwa terdapat pengaruh dari media number rods terhadap kemampuan berhitung pada anak kelompok A. Hal ini dapat dilihat dari jumlah sampel 10 anak dengan nilai pada keseluruhan nilai hasil pretest diperoleh dengan rata-rata 23,80 sebelum diberikan treatment sedangkan pada nilai hasil keseluruhan nilai posttest diperoleh dengan rata-rata 28,10. Adapun hasil hipotesis one sample T-test menunjukkan nilai signifikan 2 tailed 0,000 0,05 ditarik kesimpulan bahwa H0 ditolak dan Ha diterima.
Phylogenetic Analysis of Bengkulu Citrus Based on DNA Sequencing Enhanced Chemistry Students' System Thinking Skills: Literature Review with Bibliometrics and Experiments
Authors: Amida Nadia , Nahadi N. , Supriyanti Florentina Maria Titin , Liliasari L. , Maulana Devri , Ekaputri Rendi Zulni , Utami Indri Sari
Published: February 2025

The study aims to enhance students' system thinking skills through phylogenetic analysis based on DNA sequencing results. The study is carried out through three steps: (i) pretest: evaluate students' knowledge, (ii) treatment: analysis of affinity relationships through phylogenetics using DNA sequence data, and (iii) postest: measurement of improvement in systems thinking skills after implementation. Evaluations are conducted using written tests as well as worksheets and supported by surveys, questionnaires, and interviews for qualitative analysis. The experiment began with the isolation of citrus DNA, determination of concentration and purity, amplification, reading of sequencing results, and phylogenetics. The results of the teaching analysis show that there is a significant improvement in students' mastery of conceptual and system thinking skills, and there is a high correlation between the pretest and posttest. The problem analysis of interviews and questionnaires is also done to see the enthusiasm for activities as well as the effectiveness of the worksheets used. The study comes with new information on determining the relationship between local citrus in Bengkulu and improving the students' system thinking skills.
Implementation of Teaching at the Right Level with Problem-Based Learning Model to Increase Student Learning Outcomes
Authors: Putra Muhamad Reza Anggana , Mu'minin Dwiki Faizal , Ismatulloh M. Yosef
Published: February 2025

Schools must provide learning experiences that enhance students' abilities that aligned with the learning outcomes. Teaching at the Right Level (TaRL), combined with a Problem-Based Learning (PBL) model, is applied in Class X D at SMA Negeri 5 Bandung. TaRL offers a solution to the issue of disparities in students' abilities within a classroom. Considering the learning objectives to be achieved, the PBL model was chosen because it aligns well with programming material. The TaRL approach, using the PBL method, is designed to improve the learning outcomes of students with varying ability levels. This research successfully demonstrated an increase in average student learning outcomes, reaching 76% as measured by the n-gain score. Students with moderate ability levels achieved improvements in the "High" category, while students with high ability levels achieved improvements in the "Medium" category. These findings highlight the effectiveness of the TaRL approach with the PBL model in enhancing learning outcomes. It is recommended that TaRL combined with the PBL model be considered, as it allows students to learn at their own pace, making the learning process more student-centered and meaningful, which serves as a target for improvement.
A JOKE ABOUT TARAS SHEVCHENKO AS AN ARTIST IN THE NOTES OF IVAN PAN'KEVYCH (FROM THE PHONOGRAM ARCHIVES OF THE AUSTRIAN ACADEMY OF SCIENCES AND THE PRAGUE LITERARY ARCHIVES)
Authors:   Rylskyi Institute of Art Studies, Folklore Studies and Ethnology of the National Academy of Sciences of Ukraine, Kyiv, Shevchuk Tetiana
Published: February 2025

B a c k g r o u n d . The search and publishing of archival folklore texts about Taras Shevchenko remain a current task of the modern Shevchenko heritage studies. This research considers one iteration of the joke about T. Shevchenko and the General's Portrait painted by him.
M e t h o d s . The author employs a comparative-historical approach, while also considering the specifics of the field anthropological research methodology introduced by the Austrian scholar Rudolf Pöch in the early 20th century.
R e s u l t s . This variant was discovered by an author in two foreign archives: the Phonogram Archives of the Austrian Academy of Sciences and the Prague Literary Archives. The note was made by the Ukrainian dialectologist and folklore specialist Ivan Pan'kevych in 1915 within the framework of the Vienna anthropological project for recording of the oral speech of the First World War-era prisoners. A teacher Fedir Shevchenko from Kerelivka village, Zvenyhorodskyi powiat of Kyiv governorate, who then happened to be in the Freistadt camp (Upper Austria), was informant of I. Pan'kevych. The joke text is recorded using the phonograph and transcribed in Latin characters. It also exists in the form of a manuscript of I. Pan'kevych kept in its Fund at the Prague Literary Archives (№ 2718).
C o n c l u s i o n s . The audio recording of the anecdote about Shevchenko the artist, recorded by I. Pankiewicz, is significant for both folklorists and literary scholars, as there are few authentic texts in their arsenal that have been recorded while preserving the characteristics of oral speech. It is important to attribute this text to the informant Fedor Shevchenko specifically as an anecdote (which serves as a significant argument in attempts to determine the genre affiliation of the recording).
Proneuronal reprogramming: approaches, obstacles, and prospects
Authors: Sentyabreva Alexandra
Published: February 2025

One of the most significant scientific and technical achievements of last decades is an invention of methods making possible to reprogram cells of varying stages of differentiation in vitro, ex vivo, and in vivo. Every year, more and more experimental data declare a successful direct reprogramming of differentiated cells, including the obtaining of specialized mature neurons from glial cells in vivo. Potentially, this approach will bring the possibilities of regenerative medicine to a qualitatively new level. Despite the growing understanding of the cells differentiation and phenotypic plasticity principles, as well as the expansion of the technical abilities of manual directing these processes towards the desired result, now we cannot talk about the rapid and consistent practical application of cellular reprogramming. This review discusses the definitions of cellular plasticity, advanced achievements in the field of proneuronal cellular reprogramming using direct and indirect methods, as well as the current complexity hinders their implementation in clinical practice.
TIP regimen (paclitaxel, ifosfamide, cisplatin) in nonseminomatous germ cell tumors with poor-prognosis and unfavorable decline of serum tumor markers: final results
Authors: Israelyan E. R. , Tryakin A. A. , Rumyantsev A. A. , Fedyanin M. Yu. , Kononets P. V. , Gerasimov S. S. , Matveev V. B. , Volkova M. I. , Klimov A. V. , Semenova A. I. , Paichadze A. A. , Tsareva A. A. , Yunaev G. S. , Tjulandin S. A.
Published: February 2025

Background. Patients with germ cell tumors (GCTs) and poor-prognosis demonstrate unsatisfactory oncological outcomes, with a one-year progression-free survival (PFS) rate of approximately 50%. We hypothesized that switching the chemotherapy regimen to TIP (paclitaxel, ifosfamide (mesna), cisplatin) in cases of unfavorable decline of serum tumor markers (STMs) after the first cycle of BEP (bleomycin, etoposide, cisplatin) could improve treatment outcomes in this subgroup of patients.

Materials and Methods. A multicenter, prospective, non-randomized phase II study included patients with nonseminomatous GCTs and poor-prognosis according to IGCCCG. All patients received the first cycle of chemotherapy in the BEP regimen. Patients with an unfavorable decline of STMs subsequently received 4 cycles of TIP regimen (paclitaxel 120 mg/m² on days 1 and 2 + ifosfamide 1500 mg/m² on days 2-5 (+ mesna) + cisplatin 25 mg/m² on days 2-5 + G-CSF). In the presence of residual tumors larger than 1 cm and the technical feasibility of removal, surgical treatment was performed. The primary endpoint was one-year PFS.

Results. From 2017 to 2023, 34 patients were included in the study. Enrollment was prematurely closed due to an extremely low likelihood of achieving the primary endpoint. One-year PFS and overall survival (OS) were 57.1% and 74.4%, respectively. The favorable response rate (complete response + partial response with normalization STM) was observed in 55,8% of patients. Disease progression was observed in 21 patients, with the central nervous system being the first site of progression in 8 (37%) of them. Surgical treatment was performed in 16 patients, with viable tumor obtained in 4 patients. Conducting the first cycle in a "stabilization" mode for ultra-high-risk patients did not affect PFS (p = 0.28) or OS (p = 0.434). The toxicity profile of the TIP regimen was acceptable.

Conclusion. Switching from BEP to TIP for patients with nonseminomatous GCTs and an unfavorable decline of STMs did not demonstrate efficacy. Further exploration of alternative therapeutic approaches is needed to improve treatment outcomes.
Next-Gen Distance Learning: Propose Hologram Features Based on Students’ Perceptions of Online Teaching Tools in Visual Arts Education
Authors:   Faculty of Applied and Creative Arts, Universiti Malaysia Sarawak (UNIMAS), 94300 Kota Samarahan, Sarawak, Malaysia, Hoon Loh Ngiik
Published: February 2025

The global education system has undergone significant changes due to the COVID-19 pandemic, leading to a widespread transition to online learning. This shift has particularly affected art and design courses, which typically depend on practical, visual teaching methods and live demonstrations. To tackle these issues, this research gathered responses from undergraduate students at the university to understand how online teaching tools can enhance their distance learning experience, by gaining insights into their views on online education and the application of teaching tools such as holographic technology. Data were gathered using Likert-scale questionnaires and open-ended questions to assess students’ experiences, needs, and expectations of online teaching tools for lectures, learning activities, and assessments during the first semester of 2021. The results indicate that students favor interactive and engaging platforms like Microsoft Teams and show a strong interest in gamified learning activities. Moreover, students emphasized the importance of secure and formal online assessments. This research underscores the potential of using holograms to offer immersive and engaging educational experiences, which could revolutionize remote art and design education.
Exploring adoption dynamics
Authors: Musungwini Samuel , Van Zyl Izak , Kroeze Jan
Published: February 2025

There is a lack of acceptance, adoption and sustained use of mobile phones for agricultural purposes by smallholder farmers in  Zimbabwe, but the reasons for this have not been critically explored. In this study, the authors used a naturalistic methodology to help  uncover the nuances of adoption dynamics among smallholder farmers in Gokwe South District, Zimbabwe. Data was gathered  from in-depth interviews and focus groups. The findings suggest that gender, age, land ownership size, farming experience, mobile  device ownership, and the period of owning a mobile device are critical precursors to adoption and use. Furthermore, digital  proficiency and literacy, affluence, mobile technology services cost and telecommunication infrastructure availability are vital in  achieving continuous, sustainable use of mobile technology in the Zimbabwean agricultural sector. This research has practical  implications for policy and practice and may inform national legislation encouraging the increased use and affordability of mobile  devices in the local agricultural sector. The research also makes a theoretical contribution in terms of unpacking the key factors that  inhibit the adoption of mobile technology in marginalised settings.
Predicting the performance of ORB-SLAM3 on embedded platforms
Authors: Matthee Jacques , Uren Kenneth , Van Schoor George , Van Daalen Corne
Published: February 2025

Simultaneous Localization and Mapping (SLAM) is a crucial component to the push towards full autonomy of robotic systems, yet it is computationally expensive and can rarely achieve real-time execution speeds on embedded platforms. Therefore, a need exists to  evaluate the performance of SLAM algorithms in practical embedded environments – this paper addresses this need by creating  prediction models to estimate the performance that ORB-SLAM3 can achieve on embedded platforms. The paper uses three embedded platforms: Nvidia Jetson TX2, Raspberry Pi 3B+ and the Raspberry Pi 4B, to generate a dataset that is used in training and  testing performance prediction models. The process of profiling ORB-SLAM3 aids in the selection of inputs to the prediction model as  well as benchmarking the embedded platforms’ performances by using PassMark. The EuRoC micro aerial vehicle (MAV) dataset is used to generate the average tracking time that the embedded platforms can achieve when executing ORB-SLAM3, which is the target  of the prediction model. The best-performing model has the following results 2.84%, 3.93%, and 0.95 for MAE, RMSE and R2 score  respectively. The results show the feasibility of predicting the performance that SLAM applications can achieve on embedded  platforms.
Certyfikaty zrównoważonego rozwoju w raportowaniu niefinansowym. Szansa na zrównoważoną transformację rynku?
Authors: Warych Krzysztof
Published: February 2025

Sustainability certificates in non-financial reporting. An opportunity for a sustainable transformation of the market? The aim of this chapter was to explain what role information about sustainability
certificates can play in the non-financial reports of companies according to Corporate
Sustainability Reporting Directive. The non-financial reports of selected companies of the
Warsaw Stock Exchange were analysed. On this basis, it was found that enterprises willingly
report on the certificates they have obtained. It was identified that the above information
primarily serves to authenticate sustainable practices and may have a direct impact on the assessment of companies’ non-financial reports. They also serve as an essential element of stock
exchange announcements and thus building relationships with stakeholders and investors.
Problem konsumpcji i produkcji mięsa w kontekście zrównoważonego rozwoju
Authors: Cudnik-Cegielski Eryk , Kaczorek Karolina
Published: February 2025

Meat consumption and production in the context of sustainable development. This chapter attempts to provide a comprehensive overview of the impact of industrial meat production on key aspects related to sustainability. Issues such as the abilityto feed the expanding population with continued growth in meat consumption, considering
the industry’s impact on the environment, with massive greenhouse gas emissions, extensive
water use, and widespread deforestation or public health, including health risks related to
diets high in meat consumption and the rise of antibiotic resistance caused by excessive
antibiotic use in livestock farming, were reviewed. Based on the literature analysis it was
concluded that changes in dietary customs leading to the adoption of more sustainable food
sources are necessary to secure the future for next generations.
Investigation of the effect of SGLT-2 inhibitors on the triglyceride/glucose index in diabetic patients: a cross-sectional study
Authors: Karagöz Özen Düriye Sıla , Kayabaş Abdulcelil , İlhan Van Rana , Demirağ Mehmet Derya
Published: February 2025

Objectives: The aim of this study is to estimate the change in the Triglyceride Glucose Index (TyG index), in patients with type 2 Diabetes Mellitus who are using a sodium-glucose cotransporter-2 (SGLT2) inhibitor, and to evaluate the effect of these drugs on triglyceride glucose index.
Methods: This is a cross-sectional study of 55 diabetic patients in our internal medicine clinic in Turkey. Triglyceride, glucose, and glycosylated hemoglobin (HbA1c) values were measured at the beginning of the treatment and the 3rd-month follow-up. The TyG index of the patients before starting SGLT-2 inhibitor treatment and at the end of 3 months of treatment was calculated by the researchers using the data in the hospital digital records.
Results: The mean age of 55 patients (56.4% male) was 62.7±10.2 years. The number of patients using dapagliflozin 10 mg was 15 (27.3%) and the number of patients using empagliflozin was 41 (72.8%). It was determined that fasting plasma glucose, TyG index, and HbA1c values before starting SGLT-2 inhibitor treatment and in the 3rd month of treatment decreased significantly (P<0.001, P=0.002 and P<0.001, respectively). According to the correlation analysis results between TyG index and HbA1c, it was determined that the values both before treatment and in the 3rd month of treatment showed a correlation (r=0.516, P<0.001 and r=0.448, P=0.001, respectively).
Conclusions: SGLT-2 inhibitor usage significantly reduces TyG index in diabetic patients, and new studies are needed to investigate the effect of these drugs on triglyceride index among pre-diabetic patients.
Physico-chemical Characterisation of Ultrasound Processed Finger Millet Malt
Authors: Adoni Almas Begum , Mondru Madhava , Siliveru Kaliramesh , Sidlagatta Vishnuvardhan , Donepudi Sandeep Raja , Motamarri Swapna
Published: February 2025

Background: Finger millet (Eleusine coracana) is recognized for its high nutritional value and potential as a staple food source across various regions. However, its widespread adoption is limited due to the presence of antinutritional factors which inhibits nutrient absorption. This study investigates the effect of sonication as an innovative processing technique on the finger millet malt’s nutritional profile, antioxidant components and micronutrient bioaccessibility. Methods: During the hydration process, finger millet grains were subjected to different sonication treatments and optimized with the help of central composite design in design expert software. Parameters like Angle of Repose, water activity, water holding capacity, moisture content, color, calcium, iron and % of bioaccessibility of calcium and iron were analyzed using standard protocols. Result: Sonication treatment significantly improved the physical, nutritional and functional properties of finger millet malt. The angle of repose increased from 27.45±0.95 to 35.52±0.82, while water activity, water holding capacity (%) and moisture content (%) enhanced from 0.544±0.00 to 0.596±0.00, 201.36±0.95 to 218.36±1.96 and 7.27±0.56 to 7.88±0.48, respectively. Nutrient content showed remarkable enhancement, like calcium (mg/100 g) and iron (mg/100 g) from 323±0.13 to 341±0.45 and 3.73±0.54 to 7.12±0.22. Concurrently, antinutritional factors such as phenols (mg/100 g) and tannins (mg/100 g) decreased from 126.22 to 50.11 and 107.91 to 50.64, respectively, boosting mineral bioaccessibility. Calcium and iron bioaccessibility (%) improved from 0.51 to 36.54 and 1.92 to 58.26. Optimal conditions were observed at 18 min, 30°C and 100% amplitude, making finger millet malt a superior and palatable food ingredient.
Mentoría en la residencia médica
Authors: Olascoaga Ana Cecilia
Published: February 2025

La mentoría es una relación de desarrollo personal en la cual una persona con mayor experiencia ayuda a otra con menor experiencia. Durante la residencia médica, la relación mentor-aprendiz tiene como objetivo apoyar al residente en su desarrollo personal y profesional para que este pueda convertirse en un médico en quien se pueda confiar, preparado para el trabajo académico y clínico. En el presente artículo, se describen las características de los sistemas de mentoría en la residencia médica y la evidencia que apoya su implementación.
Escenarios de simulación de eventos críticos en médicos residentes de anestesiología
Authors: Miranda Hurtado César Jorge , Mayuri Monsefu Mónica Janet , Vidaurre Castillo Jesús Alberto
Published: February 2025

Los anestesiólogos se enfrentan a situaciones peligrosas y críticas infrecuentes, pero que siempre están como amenazas constantes. Estas situaciones se denominan “eventos críticos”. Un evento crítico es todo aquel momento dentro del curso de una enfermedad cuando se produce un cambio decisivo que conduce a la recuperación o a la muerte de un paciente. Entonces, los anestesiólogos deberán ser capaces de diagnosticar y tratar un evento crítico a través de habilidades técnicas y no técnicas, siendo estas últimas los factores determinantes de éxito.
Para el entrenamiento de habilidades no técnicas, se ha desarrollado y establecido el “manejo de recursos en crisis”, un modelo para desarrollarlas individualmente y en equipo. Por lo tanto, es necesario que los médicos residentes reciban dicho entrenamiento durante sus años de formación. Sin embargo, estos médicos tienen dificultad en el entrenamiento del manejo de recursos en crisis en sala de operaciones. La mejor estrategia de aprendizaje ante este problema es la simulación clínica. El objetivo de este ensayo sobre prácticas en docencia es describir el proceso y el desarrollo de escenarios de simulación de alta fidelidad de eventos críticos para el entrenamiento de los médicos residentes de anestesiología en manejo de recursos en crisis, junto con las dificultades, los aprendizajes y los retos futuros en este manejo.