bluuebunny/crossref_metadata_2025 huggingface dataset:
Exposomes and metabolic health through a physical activity lens: a narrative review
Authors: Gorman Shelley , Larcombe Alexander N , Christian Hayley E
Published: March 2021

In this narrative review, we provide an overview of the role of physical activity as part of differing exposomes (our combined non-genetic exposures from conception onwards) and environmental influences on metabolic health. We discuss ‘beneficial’ exposomes (green/natural outdoor spaces, sun exposure, healthy diets and features of built environments) that could synergise with physical activity to prevent metabolic dysfunction, particularly that related to lifestyle diseases of obesity, type 2 diabetes and metabolic syndrome. Physical activity may also reduce the capacity of some adverse exposomes, specifically those with significant levels of air pollution, to contribute towards metabolic dysfunction. Other exposomes, such as those experienced during pandemics (including COVID-19), potentially limit opportunities for physical activity, and there may be unexpected combined effects of physical activity with other infections (e.g. adenovirus-36) on metabolic health. Finally, we discuss how environments could be better optimised to create exposomes that promote the health benefits of physical activity and likely future directions of this research field.
Manipulating bovine granulosa cell energy metabolism limits inflammation
Authors: Horlock Anthony D , Ormsby Thomas J R , Clift Martin J D , Santos José E P , Bromfield John J , Sheldon I Martin
Published: March 2021

Bovine granulosa cells are often exposed to energy stress, due to the energy demands of lactation, and exposed to lipopolysaccharide from postpartum bacterial infections. Granulosa cells mount innate immune responses to lipopolysaccharide, including the phosphorylation of mitogen-activated protein kinases and production of pro-inflammatory interleukins. Cellular energy depends on glycolysis, and energy stress activates intracellular AMPK (AMP-activated protein kinase), which in turn inhibits mTOR (mechanistic target of rapamycin). Here, we tested the hypothesis that manipulating glycolysis, AMPK or mTOR to mimic energy stress in bovine granulosa cells limits the inflammatory responses to lipopolysaccharide. We inhibited glycolysis, activated AMPK or inhibited mTOR in granulosa cells isolated from 4–8mm and from > 8.5 mm diameter ovarian follicles, and then challenged the cells with lipopolysaccharide and measured the production of interleukins IL-1α, IL-1β, and IL-8. We found that inhibiting glycolysis with 2-deoxy-d-glucose reduced lipopolysaccharide-stimulated IL-1α > 80%, IL-1β > 90%, and IL-8 > 65% in granulosa cells from 4–8 mm and from > 8.5 mm diameter ovarian follicles. Activating AMPK with AICAR also reduced lipopolysaccharide-stimulated IL-1α > 60%, IL-1β > 75%, and IL-8 > 20%, and shortened the duration of lipopolysaccharide-stimulated phosphorylation of the mitogen-activated protein kinase ERK1/2 and JNK. However, only the mTOR inhibitor Torin 1, and not rapamycin, reduced lipopolysaccharide-stimulated IL-1α and IL-1β. In conclusion, manipulating granulosa cell energy metabolism with a glycolysis inhibitor, an AMPK activator, or an mTOR inhibitor, limited inflammatory responses to lipopolysaccharide. Our findings imply that energy stress compromises ovarian follicle immune defences.
La planeación pedagógico-didáctica implementada en el área de inglés en las comunas 1 y 2 de Bucaramanga, que atiende estudiantes en condición de vulnerabilidad en los niveles de básica y media: retos y oportunidades
Authors: Torres Hernández Jorge Wilson , Gamboa Mora María Cristina
Published: March 2021

The Colombian educational policy implemented in the period 2002- 2018 established actions for the educational attention of populations framed in the principles of inclusion and equity, focusing its interest on populations in conditions of vulnerability, and developing tools to strengthen school practices and improve the learning of the population. The objective of the research in the preliminary phase is to characterize the didactic units implemented in the English area in communes 1 and 2 of Bucaramanga, which serve vulnerable students at the elementary and middle school level. To fulfill the purpose, an exploratory and descriptive research was proposed, focused on the analysis of the content of Colombian educational legislation for the definition of emerging categories of analysis; These categories were used to assess the pedagogical-didactic planning of the institutions. It was found that the planning in the area of English projected for the vulnerable population focuses on the definition of the evaluation, and relevant aspects of the frame of reference of the National Plan for Bilingualism are neglected, such as: the inclusion of basic learning rights, implementation of the teaching material and the functions of the second language. It is concluded that planning is essential to adequately articulate the intended curriculum —which is configured based on the regulations analyzed—, the applied curriculum —which is based on planning— and the achieved curriculum —which corresponds to that expressed by students in the massive assessment tests—, which is necessary for the effective acquisition of a second language. Finally, based on the results of the characterization, challenges and opportunities arise from pedagogical-didactic planning for the area, in order to direct actions to fulfill the objectives of the National Plan for Bilingualism.
Conjetura y demostración en el aula en la formación de docentes
Authors: Balaguera Ascencio Edgar
Published: March 2021

This research work shows how the processes of conjecture and mathematical demonstration in the framework of problem solving favor the development of mathematical thinking manifested by students of the Bachelor of Basic Education with an emphasis on Mathematics of the Santo Tomás University, in the modality from distance. The methodology of this research was qualitative in nature, through case studies of the participants, and was developed under the parameters of the didactic engineering of Michèle Artigue. The theoretical framework is based on the contributions of Gila Hanna (2000) regarding the functionality of the mathematical proof, the contributions of Harel and Sowder (2007) regarding the demonstration schemes developed by the students and the resolution of problems from the Alan Schoenfeld's perspective (1985).
The Positive Procedural Obligations of States under Article 2 and 3 of the European Convention on Human Rights: Lithuanian Experience
Authors: Goda Gintaras
Published: March 2021

The article analyzes the reasons why the ECtHR finds violations of Articles 2 and 3 of the ECHR quite often in cases against Lithuania. The investigation aims to reveal the main mistakes made by the subjects of pre-trial investigation and the courts, which lead to violations of the ECHR.
A. M. REMIZOV’S “THEORY OF RUSSIAN LITERARY STYLE” (1930S‒1950S)
Authors: Gracheva Alla
Published: March 2021

The article analyzes the stages of development of A. M. Remizov’s “theory of Russian literary style” (“teoriya russkogo lada”) in the 1930s–1950s. In the 1930s, the opportunities for the writer to present his aesthetic views in an open journalistic form narrowed down significantly. Remizov was forced to popularize his theory and the name of its “founder” — protopope Avvakum in works devoted to other topics (Knigopisets i shtanba, Po sledam protopopa Avvakuma v SSSR, etc.). In these years, the conceptual apparatus of the theory has taken shape, the semantics of the term “theory of Russian literary style” was detailed. In 1946, Remizov made the last, unsuccessful attempt to publish an introduction to his theory in the form of a manifesto (Na russkiy lad, 1946). The exposition of this theory’s postulates was an indispensable part of most of Remizov’s works of the late 1940s-1950s. Plyashuschiy Demon (The Dancing Demon), an avant-garde book, reveals the ongoing confrontation between the supporters and opponents of the “theory of Russian literary style” up to the 20th century through a historical kaleidoscope of characters from different periods of Russian history. Related novels. i. e. Uchitel muzyki (The Music Teacher) and Podstrizhennymi glazami (By Cropped Eyes) are devoted to examining the mystery of the formation of a writer's personality, and reflect the Russian art life in the 19th-20th centuries and in the first wave of Russian emigration. The writer's emerging personality, the formation of its aesthetic foundation is historically and culturally justified in both books. The writer in question is a follower of “theory of Russian literary style.” This very theme is one of the central topics in Remizov's latest work — his book about himself Litso pisatelya (The Face of a Writer).
THE SENSE-GENERATING ROLE OF BIBLICAL TEXT IN LYDIA NELIDOVA’S STORY POLOSA
Authors: Golovko Vyacheslav
Published: March 2021

The article analyzes the semantic functions of the Old Testament and New Testament texts in the story Polosa (Stripe), a landmark for the literature of the final stage of Russian classical realism, written by Lydia Nelidova, whose work has not yet been the subject of special study. The relevance of the research is defined by the rather high role of Nelidova’s creative activity in the literary process of the last decades of the 19th century. Biblical references, quotations, reminiscences, allusions and paraphrases, which determine the sequence of the text that creates the semantic field of the work, perform the dominant ideological and aesthetic function in creating the story as a “non-trivial new text.” Nelidova’s innovation is based on the active use of Dostoevsky’s literary traditions (orientation toward the idea of “finding a person in a person” and the “living life” constant). As a “semantic whole,” Nelidova’s story is organized by the internal dialogue of three concepts of “life.” One of them is based on the Christian teaching, the other on an appeal to science, and the third – on the idea of life as an all-dominating objective force. The author's moral and aesthetic position, which confirms the biblical concept of life, is objectified in the logic of semantic actualization of the gospel truths associated with the interpretations of the eternal theme of the struggle between good and evil, ways of human salvation, overcoming the sin of thoughts, pride and selfishness. The artistic historicism of the story, manifested in the coverage of the social contradictions of the post-reform Russia, sanctions the author’s intentionality associated with the assertion of universal human spiritual, moral and humanistic ideals. Formation of meaning at the level of the author’s intentionality and at the level of meaning generation is carried out by activating the intertextual, hypertextual and contextual functionality of biblical pretexts and traditions of Orthodox Christian culture. It is implemented in the process of illuminating conflicts of time and characters' psychological disclosure. Intertextual reminiscences and quotes from biblical texts, the works of Christian ascetic writers and patristic sources aim to form the semantic core of the main character’s narrative and implement the principle of intersemantization of meanings enshrined in sacred texts. Thanks to these texts, they manifest in the thoughts of a character seeking a way out of spiritual and moral impasse. The author's artistic experience stimulated the formation of the Dostoevsky school in the literature of the last decades of the 19th century. The author's quote-based thinking anticipates the narrative strategies that will become characteristic of the artistic discourse of subsequent historical and literary eras.
Educación Corporizada para la Convivencia
Authors: Cely Avila Flor Emilce
Published: March 2021

En este artículo propongo defender una educación para la convivencia desde edades muy tempranas que (1) parta de una comprensión correcta de la naturaleza corporal, activa y afectiva del ser humano; (2) entienda lo indispensable que es implementar pedagogías alternativas y novedosas que promuevan una educación basada en la utilización del cuerpo entero en las actividades de enseñanza/aprendizaje; y (3) confíe e integre en sus prácticas los resultados de investigaciones empíricas hechas a partir de bases teóricas robustas. El énfasis estará puesto en la necesidad de implementar metodologías y pedagogías novedosas y creativas, basadas en algunos postulados de la fenomenología, así como en algunas hipótesis de los enfoques contemporáneos de cognición corporizada y situada.
 
Cómo citar este artículo: Cely, F.E. (2021). Educación Corporizada para la Convivencia. Revista Colombiana de Psicología, 30(1), 63-77. https://doi.org/10.15446/rcp.v30n1.71764
Medidas Implícitas en Cognición: Una Aproximación al Estudio de la Automaticidad
Authors: Parra José Alirio , Tamayo Ricardo Mauricio
Published: March 2021

La investigación en cognición implícita ha aumentado de manera vertiginosa durante las últimas décadas, principalmente por el uso generalizado de procedimientos experimentales conocidos como medidas implícitas. A diferencia de los cuestionarios de autoinforme, estas metodologías impiden que sesgos como la deseabilidad social afecten las respuestas de los participantes, lo que permite abordar temas sensibles. Sin embargo, las medidas implícitas difieren en aspectos como las instrucciones, los materiales o los indicadores conductuales analizados. Debido a esto, hay controversia sobre la naturaleza de los procesos que están siendo medidos, las características que se les atribuyen y, por ende, la posibilidad de hacer comparaciones entre los estudios que emplean diferentes medidas implícitas. Basándose en un modelo de procesamiento dual, este trabajo propone que las medidas implícitas pueden entenderse como indicadores de procesos automáticos. A partir de dicha propuesta, se discuten los requisitos que las medidas implícitas deben cumplir y algunos desafíos para la investigación en automaticidad.
 
Cómo citar este artículo: Parra, J. A., & Tamayo, R. M. (2021). Medidas Implícitas en Cognición: una Aproximación al Estudio de la Automaticidad. Revista Colombiana de Psicología, 30(1), 89-110. https://doi.org/10.15446/rcp.v30n1.85106
Religious Syncretism among Indian Muslims and Its Manifestation in Dargah Practices
Authors: Samseer R. H. , Beegom R. K. Bushra
Published: March 2021

The article explores a syncretic form of Islam in India in the context of the emergence of essentialist and puritanical religious discourses. The changes that such discourses can bring in the moral constitution of Muslims can disturb their harmonious integration with the religio-cultural elements of their immediate environment. The historical analysis of this phenomenon traces the syncretic nature of the social and economic exchanges between Hindus and Muslims, convergence of the spiritual aspects of bhakti and Sufism, and how Sufi shrines became cultural centres for both Muslims and Hindus. The article also situates the Moplah Rebellion in the context of syncretism in Kerala. The study makes an in-depth inquiry into the syncretic form of Islam prevailing in the dargahs in the state. The inquiry should aid understanding of the present state of syncretic identification among Muslims in Kerala.
Oral allergy syndrome by fruit and vegetable PR-10 allergy: Accuracy of in vivo diagnosis
Authors: De Rose Cristina , Patti Maria Letitzia , Gambacorta Alessadro , Brancato Federica , Miceli Sopo Stefano
Published: March 2021

Routine diagnostic methods for allergies to plant-derived foods are based on skin prick test (SPT) with commercial extracts, prick-by-prick (PbP) with fresh food, serum-specific IgE measurement, and oral food challenge.We discuss the possibility and the advantages of performing, in patients with oral allergy syn-drome (OAS) by fruit and vegetables (excluding nuts) PR-10 allergy, component-resolved diag-nosis (CRD) by SPT and PbP with raw and cooked vegetables, rather than performing a CRD with in vitro tests by drawing blood.Based on our clinical experience and the studies published in the literature, we believe that, at least for the OAS by fruit and vegetables (excluding nuts) PR-10 allergy, the search for sensitizing allergens and related cross-reactive allergens with SPT and PbP can be performed routinely in clinical practice, even at the primary-care level.
Evaluation of miR-210 expression in common variable immunodeficiency: patients with unsolved genetic defect
Authors: Babaha Fateme , Yazdani Reza , Shahkarami Sepideh , Hamidi Esfahani Zahra , Abolhahassani Hassan , Sadr Maryam , Zavaran Hosseini Ahmad , Aghamohammadi Asghar
Published: March 2021

Background: Common variable immunodeficiency (CVID) is one of the most prevalent forms of primary immunodeficiency diseases (PID). CVID is characterized by failure in the final differentiation of B lymphocytes and impaired antibody production but the pathogenesis is not known in the majority of patients. We postulated that the expression pattern of miRNAs in unsolved CVID patients might be the underlying epigenetic cause of the disease. Therefore, we aimed to assess the expression of hsa-miR-210-5p and FOXP3 transcription factor in CVID cases in comparison with healthy individuals.
Methods: Eleven CVID cases with no genetic defects (all PID known genes excluded) and 10 sex and age-matched healthy individuals were enrolled in the study. T lymphocytes were purified from PBMC, and expression levels of miR-210-5p and FOXP3 mRNA were evaluated by real-time PCR.
Results: We demonstrated that miR-210 expression in patients was significantly higher than the control group (P = 0.03). FOXP3 expression was slightly lower in patients compared with healthy controls (P = 0.86). There was a negative correlation between miR and gene expression (r: −0.11, P = 0.73). Among various clinical complications, autoimmunity showed a considerable rate in high-miR patients (P = 0.12, 42.8%), while autoimmunity was not observed in normal miR-210 patients.
Conclusions: Our results suggest a role for miR-210 in the pathogenesis of autoimmunity in CVID patients. Further studies would better elucidate epigenetic roles in CVID patients with no genetic defects.
Rapid weight gain in early life is associated with severity of respiratory syncytial virus (RSV) bronchiolitis in children
Authors: Ree Kim You , Kyoun Cho Hak , Hye Lee Eun , Choi Yong-Sung , Yoon Hoi Soo , Han Mi Young , Ho Rha Yeong , Woon Jung Hae
Published: March 2021

Objectives: This study aimed to investigate whether rapid weight gain in early life was associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children.Methods: We retrospectively reviewed 190 patients (1–24 months) hospitalized for RSV bronchiolitis. Parameters of bronchiolitis severity were compared between rapid (change in weight z-score from birth >0.67, n = 65) and normal weight gain groups (n = 125). We assessed for correlations between bronchiolitis severity and weight gain. Linear regression was performed to predict for bronchiolitis severity based on weight gain, controlling for covariates. SPSS was used for statistical analyses.Results: The rapid weight gain group had longer mean durations of tachypnea (2.3±2.0 vs. 1.7±1.8 days, P = 0.027), wheezing (3.2±2.5 vs. 1.6±1.8 days, P < 0.001), and chest retractions (1.5±2.2 vs. 0.6±1.3 days, P = 0.007). Correlations of weight gain with tachypnea (r = 0.146), wheezing (r = 0.279), and chest retractions (r = 0.179) were statistically significant. Weight gain predicted for tachypnea (B = 0.485, P = 0.013) and wheezing (B = 0.846, P = 0.001) durations after adjusting for covariates of severity (age, sex, current weight, RSV type, coin-fection, recurrent bronchiolitis, hospital stay, fever, oxygen supplementation, maximal respi-ratory and heart rates, and laboratory indices).Conclusions: Our findings suggest an association between weight gain and severity of RSV bronchiolitis in young children. Weight gain was significantly associated with the durations of tachypnea and wheezing. The trajectory of weight gain in early life may play a significant role in the clinical course of RSV bronchiolitis.
A REVIEW OF THE METHODS OF ECONOMIC AND MATHEMATICAL MODELING BASED ON THE PRINCIPLES OF ECONOPHYSICS. PART 1
Authors:   Perm State University, Andrianov Dmitrii , Simonov Petr ,   Perm State University
Published: March 2021

A review of theoretical and applied results obtained in the framework of the scientific direction in econophysics at the Department of Information Systems and Mathematical Methods in Economics is given. The first part gives the concept of a financial bubble and methods for their search. The review covers the period 2010-2019. A review of theoretical and applied results obtained in the framework of the scientific direction in econophysics at the Department of information systems and mathematical methods in Economics is given. The first part gives the concept of a financial bubble and methods for finding them. At the beginning of the article, the development of econophysics is given. Therefore, using the research of physicists as a model, econophysics should begin its research not from the upper floors of an economic building (in the form of financial markets, distribution of returns on financial assets, etc.), but from its fundamental foundations or, in the words of physicists, from elementary economic objects and forms of their movement (labor, its productivity, etc.). Only in this way can econophysics find its subject of study and become a "new form of economic theory". Further, the main prerequisites of financial bubble models in the market are considered: the principle of the absence of arbitrage opportunities, the existence of rational agents, a risk-driven model, and a price-driven model. A well-known nonlinear LPPL model (log periodic power law model) was proposed. In the works of V. O. Arbuzov, it was proposed to use procedures for selecting models. Namely, basic selection, "stationarity" filtering, and spectral analysis were introduced. The results of the model were presented in the works of D. Sornette and his students. The second part gives the concept of percolation and its application in Economics. We will consider a mathematical model proposed by J. P. Bouchaud, D. Stauffer, and D. Sornette that recreates the behavior of an agent in the market and their interaction, geometrically describing a phase transition of the second kind. In this model, the price of an asset in a single time interval changes in proportion to the difference between supply and demand in this market. The key situation to study is the moment of formation of an infinite cluster on the percolation grid, since this means the collapse of the market, when the overwhelming part of agents for this market has a similar opinion about their actions to buy or sell an asset. The main characteristics of the process are the threshold probability of market collapse, as well as the empirical distribution function of price changes in this market.
On Convergence of Polynomial Approximate Solutions of Minimal Surface Equations in Domains Satisfying the Cone Condition
Authors: Trukhlyaeva Irina
Published: March 2021

In this paper we consider the polynomial approximate solutions of the minimal surface equation. It is shown that under certain conditions on the geometric structure of the domain the absolute values of the gradients of the solutions are bounded as the degree of these polynomials increases. The obtained properties imply the uniform convergence of approximate solutions to the exact solution of the minimal surface equation.

In numerical solving of boundary value problems for equations and systems of partial differential equations, a very important issue is the convergence of approximate solutions.The study of this issue is especially important for nonlinear equations since in this case there is a series of difficulties related with the impossibility of employing traditional methods and approaches used for linear equations. At present, a quite topical problem is to determine the conditions ensuring the uniform convergence of approximate solutions obtained by various methods for nonlinear equations and system of equations of variational kind (see, for instance, [1]). For nonlinear equations it is first necessary to establish some a priori estimates of the derivatives of approximate solutions.In this paper, we gave a substantiation of the variational method of solving the minimal surface equation in the case of multidimensional space.We use the same approach that we used in [3] for a two-dimensional equation. Note that such a convergence was established in [3] under the condition that a certain geometric characteristic Δ(Ω) in the domain Ω, in which the solutions are considered, is positive. In particular, domain with a smooth boundary satisfied this requirement. However, this characteristic is equal to zero for a fairly wide class of domains with piecewise-smooth boundaries and sufficiently "narrow" sections at the boundary. For example, such a section of the boundary is the vertex of a cone with an angle less than π/2. In this paper, we present another approach to determining the value of Δ(Ω) in terms of which it is possible to extend the results of the work [3] in domain satisfying cone condition.
Transportation Planning with Minimal Costs
Authors: Khizhnyakova Ekaterina
Published: March 2021

In this paper, the classical problem of optimal transport plan is considered taking into account the capacity of certain sections of the transport network. Let vpq units of goods be delivered from point p to point q. At thesame time, each section of the transport network has a limited capacity, which is expressed in a certain volume of goods that can be passed through it per unit of time.

The goal is to distribute goods flows along different routes in such a way that all transport needs are completely satisfied, the roads are not overloaded, and at the same time the total transport costs (for example, in the form of fuel consumption,time costs, etc.) reach their minimum. It should be noted that without restrictions on capacity, the task is solved trivially: it is necessary to distribute all transportation from point p to point q on the shortest route. To solve this problem, a mathematical model of the transport network is formulated. It is proposed to reduce the solution of the this problem to the solution of the linear programming problem. As a result, we propose an algorithm for planning transportation in such a way that the total costs will be the lowest. In addition, one of the algorithm steps required solving the problem of finding the k-th path along the length between 2 nodes. To solve this problem, the corresponding algorithm is proposed. This algorithm is recursive.
Estimation of ice-liquid plasma phase transition using electronic test equipment
Authors:   Urals Optical-Mechanical Plant, Zhdanov A. E. ,   Ural Federal University, Dorosinskiy L. G. ,   Ural Federal University, Borisov V. I. ,   Ural Federal University, Negodyaev K. E. ,   Ural Federal University, Evdochim L. ,   Polytechnic University of Bucharest,   Infineon Technologies Romania SCS
Published: March 2021

One of the most dynamically developing areas of knowledge is modern medicine. In many ways, the pace of development of medicine is determined by technological capabilities. The blood service is one of the most technologically saturated branches of medicine since the quality of the final product and the patient’s health depend on the processing technology of the blood and its components. According to the technical regulations on the safety requirements of blood, its products, blood-substituting solutions and technical means used in transfusion-infusion therapy, approved by the Government of Russia on 01/26/2010: “The components of donated blood must be thawed and heated to the required temperature using specially designed equipment”. Defroster for cryopreserved blood products are specialized technical means used to measure electrical, magnetic and electromagnetic quantities characterizing the temperature parameters of the object to be thawed and heated. In the field of defrosting and heating cryopreserved blood products for transfusion-infusion, the fundamental task is to develop a software solution for simulating defrosting systems, which can make it possible to determine the optimal parameters of defrosting systems at the stage of pre-model modeling. This article describes an experimental study to evaluate the phase transition of an ice-liquid plasma during defrosting using radio measuring equipment. The obtained data will be used to create a mathematical model of the process of defrosting blood products.
The gravitational radiation power of the blazar OJ 287
Authors:   Radio Astronomy and Geodynamics Department of Crimean Astrophysical Observatory RAS, Volvach A. E. , Volvach L. N. ,   Radio Astronomy and Geodynamics Department of Crimean Astrophysical Observatory RAS, Larionov M. G. ,   Astro Space Center, Lebedev Physical Institute, Russian Academy of Sciences
Published: March 2021

Using a new model based on the consideration of close binary systems (CDS) of supermassive black holes (SMBHs), we obtained data for the OJ 287 blazar, which is necessary for finding the parameters of the OJ 287 gravitational radiation. We used the results of multi-frequency monitoring performed only in the radio band. The application of harmonic analyses of observational data allowed us to construct a model of CDS consisting of two SMBHs of comparable masses, which made it possible to find the power of gravitational radiation coming from OJ 287, variations in the orbit of the double SMDS, and to consider the possibility of experimentally determining changes in these parameters in the system. Variants of radiation of electromagnetic and gravitational waves coming from OJ 287 in various states of object activity are considered.
Conclusion: Why Struggles Against Platform Capitalism Matter
Authors: Woodcock Jamie
Published: March 2021

The conclusion of the book draws together each of the examples of platform work and of its analysis, emphasising and reiterating the key argument of the book: that rather than undermining worker agency, platforms have instead provided the technical basis for the emergence of new global struggles against capitalism.
ARTISTIC TERMS IN THE TITLE OF “COLD WALLS”
Authors:   Osmonov National Library, Bakashova Zhyldyz
Published: March 2021

The process of title of a work requires skill from the writer, since each title should briefly report not only on its content, but also convey its essence, ideological purpose, and some hidden meaning. Along with simple names, there are complex, symbolic names. Such names include K. Zhusubaliev’s novel Cold Walls. In this novel, K. Zhusubaliev appears as a writer with a peculiar perception of reality, with his own truth, poetic innovation. The symbolism of the name "Cold Walls" is very important. This title already speaks of his idea, emotionally preparing the reader’s perception. The article analyzes the semantic relationships of the title and content of the work, shows their inextricable unity, non-standard and originality. “Walls” is a symbol of life that holds a person tightly within its framework, without giving it a way out. And “cold” is a symbol of indifference, powerlessness, loneliness.
ABOUT CREATING FREQUENCY DICTIONARIES THE WORKS OF SHERKHAN MURTAZA
Authors:   Taraz Innovation and Humanities University, Belbotaev Almazbek , Sadykov Tashbolot ,   Alatoo International University
Published: March 2021

The article deals with the initial stage of the activity of the Sherkhan Research center created in Taraz innovation and Humanities University, which aims to study the language and vocabulary of the works of the Kazakh writer Sherkhan Murtaza and create frequency dictionaries of various types for the works of the writer. At the same time discusses issues related to collecting all works by the writer published in the Kazakh language, the definition of their genre and style, compilation of frequency dictionaries, lexico-grammatical analysis of each text words and indexing them on the grounds of part-of-speech affiliation.
CARBON EMISSIONS FROM MOUNTAIN-VALLEY LIGHT-CHESTNUT SOILS OF THE ISSYK-KUL BASIN
Authors:   Kyrgyz National Agrarian University, Mamytkanov Sovetbek , Karabaev Nurudin ,   Kyrgyz National Agrarian University
Published: March 2021

The article considers the accumulation and mineralization of soil organic matter that leads to carbon emissions into the atmosphere. There are the results of humus loss of arable lands over 10 years of exploitation in irrigated agriculture in terms of converting to carbon and the changes in the content of organic matter over the last 20 years of irrigated mountain- valley light-chestnut soils of the Issyk - Kul basin. It also considers the problems of reducing the productivity of light-chestnut soils that occur as a result of climate change, which will have serious negative consequences for the country's economy, people's livelihoods and food security.
COMPARAÇÃO ENTRE DOIS AMBIENTES VIRTUAIS DE APRENDIZAGEM (AVA´S) EM RELAÇÃO A INTERAÇÕES E DESEMPENHO EM CURSOS DE PÓS-GRADUAÇÃO NA MODALIDADE A DISTÂNCIA
Authors:   UNIVERSIDADE LUTERANA DO BRASIL, SILVA PAULA MAINES DA
Published: March 2021

A EDUCAÇÃO A DISTÂNCIA (EAD) VEIO AO ENCONTRO DE TODAS AS NECESSIDADES EMERGENTES DESTE NOVO MUNDO QUE CONTEMPLA O AVANÇO DAS TECNOLOGIAS, A VELOCIDADE DAS INFORMAÇÕES E A ROTINA CADA VEZ MAIS INTENSA. COM ISSO, SURGE O PERFIL DE UM NOVO ALUNO, NO QUAL DEMANDA NOVAS METODOLOGIAS, NOVAS FERRAMENTAS E NOVAS TEORIAS DE APRENDIZAGEM PARA O DESENVOLVIMENTO INTELECTUAL. PARA QUE ISSO OCORRA AS INSTITUIÇÕES DE ENSINO ESTÃO UTILIZANDO FERRAMENTAS DE TECNOLOGIA DE INFORMAÇÃO E COMUNICAÇÃO E OS AMBIENTES VIRTUAIS DE APRENDIZAGEM – OS AVAS. NESTE CONTEXTO ESTE ESTUDO TEVE COMO OBJETIVO REALIZAR UM COMPARATIVO ENTRE A INTERAÇÃO E DESEMPENHO DOS ALUNOS DE CURSOS DE PÓS-GRADUAÇÃO EM DOIS AMBIENTES VIRTUAIS DE APRENDIZAGEM, A PLATAFORMA NETAULA E O AMBIENTE AULA. TRATA-SE DE UMA PESQUISA DESCRITIVA, TENDO COMO BASE DADOS SECUNDÁRIOS DISPONIBILIZADOS EM CADA AMBIENTE VIRTUAL INVESTIGADO NAS SALAS DE AULA DE DIFERENTES DISCIPLINAS DE PÓS-GRADUAÇÃO. OS RESULTADOS FORAM ANALISADOS ATRAVÉS DE ESTATÍSTICAS DESCRITIVAS, COMO PRINCIPAIS RESULTADOS DESTACA-SE A IMPORTÂNCIA DE UM AMBIENTE VIRTUAL MAIS AMIGÁVEL, COM TECNOLOGIA MODERNA E RECURSOS QUE PERMITAM MAIOR INTERAÇÃO ENTRE PROFESSOR E ALUNO, UMA PLATAFORMA COM MAIOR VARIEDADE DE FERRAMENTAS, MAIS MODERNA E INTERATIVA REDUZIU SIGNIFICATIVAMENTE O PERCENTUAL DE REPROVAÇÕES NAS DISCIPLINAS INVESTIGADAS.
AVALIAÇÃO DE PROGRAMAS DE FORMAÇÃO EM GESTÃO: A PERSPECTIVA DE DIRETORES DE ESCOLAS DA EDUCAÇÃO BÁSICA DO RIO DE JANEIRO
Authors:   FUNDAÇÃO GETULIO VARGAS, SANTOS VINÍCIUS FARIAS , DINIZ DANIELA MARTINS ,   UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL REY, NOGUEIRA JAANA FLÁVIA FERNANDES ,   FUNDAÇÃO GETULIO VARGAS, OLIVEIRA FÁTIMA BAYMA DE ,   FUNDAÇÃO GETULIO VARGAS
Published: March 2021

ESTE ESTUDO TEVE COMO OBJETIVO IDENTIFICAR COMO INSTITUIÇÕES PODEM AVALIAR AS CONTRIBUIÇÕES DE PROGRAMAS DE FORMAÇÃO EM GESTÃO NO CONTEXTO DA EDUCAÇÃO BÁSICA BRASILEIRA. QUANTO AO MÉTODO, O ESTUDO PODE SER CARACTERIZADO COMO MISTO ENVOLVENDO ASPECTOS DE NATUREZA QUANTITATIVA E QUALITATIVA, COM O INTUITO DE TESTAR O MODELO DE GROHMANN E KAUFFELD (2013), PARA AVALIAR UM CURSO SEMIPRESENCIAL DE GESTÃO ESCOLAR. COMO INSTRUMENTOS DE COLETA, FORAM UTILIZADOS 126 QUESTIONÁRIOS PARA UMA ANÁLISE QUANTITATIVA E 8 ENTREVISTAS COM DIRETORES DE ESCOLAS PARA APROFUNDAR AS VARIÁVEIS QUE INFLUENCIAM A AVALIAÇÃO DA FORMAÇÃO. OS ACHADOS INDICAM QUE A FERRAMENTA CRIADA POR GROHMANN E KAUFFELD (2013) SE MOSTROU ADEQUADA PARA A AVALIAÇÃO DE PROGRAMAS DE FORMAÇÃO. OS RESULTADOS APONTAM, TAMBÉM, PARA UMA AVALIAÇÃO POSITIVA DOS INDICADORES DE CURTO PRAZO, TENDO VARIÁVEIS COMO IDADE, ESCOLARIDADE E LOCALIZAÇÃO COMO DETERMINANTES; UMA AVALIAÇÃO NEUTRA A LONGO PRAZO, TENDO VARIÁVEIS COMO CARGO E LOCALIZAÇÃO COMO DETERMINANTES; A NECESSIDADE DE FORMAÇÕES MAIS APROFUNDADAS E DE MAIOR DURAÇÃO, QUE ABORDEM SITUAÇÕES PRÁTICAS DO COTIDIANO ESCOLAR E A ADEQUAÇÃO DO CONTEÚDO AO NÍVEL DE EXPERIÊNCIA DO PÚBLICO NO CARGO.
Tissue Staining for Imaging Mass Cytometry v1
Authors: Herndon John , Carmody Madelyn , Oh Stephen , William Gillanders Washington University St Louis not provided
Published: March 2021

This protocol describes the preparation and staining of human FFPE material for multiplex visualization using Imaging Mass Cytometry (IMC). This protocol uses basic standard immunohistochemical staining techniques. The tissue is incubated with antibodies that have specific affinity for different cells and tissues in the context of a formalin fixed thin section of human tumor material. Antibodies are labeled with heavy metals instead of the typical fluorochromes, and are visualized using the Hyperion Imaging System manufactured by the Fluidigm corporation.
S.O.F protocol for nuclei isolation from fresh and frozen tissues using OptiPrep® discontinuous gradient v4
Authors: G Martelotto Luciano
Published: March 2021

This protocol is the result of the combination of various nuclei isolation protocols for single cell RNA-seq experiments using droplet-based methods, and is an extension of the Frankenstein (S.O.F means Son Of Frankenstein). Developed to prepare nuclei isolates from fresh and frozen material of small-to-large sizes. The good thing is that it does not uses FACS but OptiPrep® discontinuous gradient to remove debris. It is the alternative protocol when FACS is not available.
Searching for the Origin of Agriculture in East Asia
Authors: Vostretsov Yurii E.
Published: March 2021

Neolithization of East Asia took place against the background of catastrophic landscape and environmental changes. The “sudden” appearance of early farmers in already developed type of cultures such as Peiligang and Cishan has not been studied enough. It is necessary to clarify the origins and reasons for the wide distribution of both early farmers and the “wide range of hunter-gatherers.” The article considers the territory where the transition to agriculture could take place, as well as a set of environmental influence factors in the late Pleistocene and early Holocene, which influenced the choice of behavioural survival strategies. The paleogeographic model of transition to agriculture in East Asia proposed in the article, considers the paleoplain that existed in the territory of the modern shelf of the Yellow Sea as the most likely area where plant domestication could originate. The tendencies of changes in the landscape structure of the paleoplain territory during the cooling and warming periods, associated with sea level fluctuations, have been reconstructed. The boundaries of maximum marine transgression, as well as the zone of flooding and destruction of the early farmers’ settlements have been determined. It has been found out that all the preserved sites of early cultivators and farmers are on the border of the marine transgression peak, creating the effect of their “sudden” appearance. In the context of paleogeographic reconstructions, it has been suggested that transition to the cultivation and domestication of millet and rice started simultaneously on the paleoplain during the cooling of the Older and Younger Dryas, and was additionally “motivated” by two subsequent coolings at the early Holocene. As a result of the marine transgression, the mouths of the Huang He and the Yangtze rivers diverged to the south and north, as well as the territorial specialisation of early farmers in cultivating rice and millet. The similarity of some features of the material culture of the Early Neolithic of North and South China is determined by the fact that they originated from a common centre
Problem of Determining a Multidimensional Kernel in One Parabolic Integro–differential Equation
Authors: Durdiev Durdimurod K. , Nuriddinov Zhavlon Z.
Published: March 2021

The multidimensional parabolic integro-differential equation with the time-convolution in- tegral on the right side is considered. The direct problem is represented by the Cauchy problem for this equation. In this paper it is studied the inverse problem consisting in finding of a time and spatial dependent kernel of the integrated member on known in a hyperplane xn = 0 for t > 0 to the solution of direct problem. With use of the resolvent of kernel this problem is reduced to the investigation of more convenient inverse problem. The last problem is replaced with the equivalent system of the integral equations with respect to unknown functions and on the bases of contractive mapping principle it is proved the unique solvability to the direct and inverse problems
VERTICAL DISPLACEMENT MONITORING OF ZAKARPATTYA REGION TERRITORY BASED ON RADAR INTERFEROMETRY DATA
Authors: Uglitskih E. , Vyzhva S. , Ivanik O.
Published: March 2021

The article presents result of deformation monitoring in Zakarpattya region, performed using the method of radar interferometry. The method of radar interferometry allows to monitor the displacements of the earth's surface in real time and quickly obtain up-to-date data. As a result of the research of the Carpathian model landfill, 26 pairs of interferograms for the period 2016–2018 were processed. As a result of these operations, a general map of vertical displacements of the earth's surface of the Carpathian model landfill was constructed. The territory is ranked into 3 zones according to the indicators of vertical displacements of the earth's surface. It is confirmed that the use of interferometry data is effective for detailed analysis of the regime and dynamics of dangerous geological processes. These surveys are of great value and with good resolution and appropriate processing algorithm give reasonable results and conclusions, which in combination with lithological-stratigraphic, geomorphological and structuraltectonic studies can be used to predict dangerous geological processes and minimize their negative impact on nature and man-made systems.
Study of Effective Environmental Engineering Impact Assessment on Coal Mining Projects
Authors: Pearce Kai
Published: March 2021

The mineral asset abuse assumes a significant function in monetary turn of events, yet it additionally causes numerous natural issues, particularly environmental issue. In coal mining, so as to accomplish feasible utilization of these assets, we should give exceptional consideration to eco-ecological insurance. This article first quickly presented the current status of natural designing effect evaluation and afterward talked about the time viability of appraisal through the investigation of its present status, utilizing ecological security check and acknowledgment in coal mining ventures. The creators consider that one-time evaluation of ecological effect on the coal tasks and "three synchronous" acknowledgment of the coal ventures executed in china as of now isn't sensible.
Eco-Efficiency Analysis of Environmental and Industrial Engineering
Authors: Probst Karin
Published: March 2021

With the expanding weighty weight from condition and nature asset, individuals has taken creative measures to liberate themselves from the current unreasonable financial improvement design, and unequivocally advanced the improvement of round sort and ecotype economy. The fundamental undertakings of eco-mechanical building are to bring the thoughts of ecotype into the plan of modern framework dependent on the speculations of roundabout economy, and accomplish the agreement of financial advantage and natural advantage. So as to acquire viable use proportion of asset and lower condition contamination, eco-effectiveness consolidates economy with condition. This paper dependent on exploring eco-proficiency markers framework, calls attention to eco-mechanical designing assessment strategies because of the eco-effectiveness.
Fuzzy Logic based Environmental Engineering System for Assessment of Mining Area Safety
Authors: Bürger Luca
Published: March 2021

Mining territory's natural building framework security evaluation is the thorough measure for the state and advancement patterns of mining zone's ecological framework, and it is the significant premise to take explicit measures to control the mining region's natural framework wellbeing. In this paper, under the direction of the weight - state - reaction, the mining territory's ecological framework wellbeing appraisal record model was developed, and utilizing the fluffy control hypothesis, a thorough evaluation model was built dependent on fluffy rationale, and the model have been confirmed by a coal mining zone.
A Real-time Forest Monitoring System for Environmental Engineering Data Applications
Authors: Boxman Raven
Published: March 2021

The woods environment is basic for providing common assets to the greenery. The woods is an indispensable safe-haven, albeit at present it is presented to illicit logging by insatiable individuals, and this has altogether influenced the woodland. Because of this criminal behavior, unfortunate wonder has surfaced. Consequently, the system of this exploration is worried about building up a far off observing gadget that could catch basic ongoing information, for example, temperature, moistness, vaporous substance, and bonfire and downpour location, which could show the recent and the safeguarded characteristic state and environment in the woods. The model was actualized at chosen areas to screen and assemble information at two stages. The results from this exploration will be utilized in the advancement of a progression of games as instructing helps that can make mindful our group of people yet to come about the consumption and its effect upon the earth.
Environmental Engineering Research on Wetland Monitoring and Protection Based on Field Server
Authors: Bennett Imogen
Published: March 2021

Observing and assurance of biological natural is the outskirts grassland and gone to by various diverse field researchers in the advanced occasions. This exploration is the soonest move up and establishes the idea of field worker framework model, in other words, through AI, make computerized video to syncretise with the WLAN strategy, and send the boundaries of wetland biological ecological elements to worker by LAN. This can take care of certain issues of simple microwave correspondence frameworks, for example, recurrence asset conveyance, recurrence possessing and radio waves obstruction. This is additionally ready to take care of issue of  pre-treatment and rapidly extends video checking framework in some recurrence band, get great impact and stabile picture and information in the control community.
An Unhealthy Buying Pattern of the Peoples of Bangladesh: A Case of Tobacco & Beverage
Authors: Niloy Ahnaf Chowdhury
Published: March 2021

Bangladesh is a comparatively small country but a densely populated country that has attracted several big companies to come and run their business including carbonated drinks and tobacco. International beverage brands like coca-cola, Pepsi, etc., and tobacco brands like British American Tobacco, Philip Morris International, etc. are doing great business in Bangladesh alongside local brands. Even though for business, these products are a must but when it comes to health issues these are such products that affect physically greatly. Matter of consciousness comes when the consumer is giving preference to such products more than essential consumables that are seen in Bangladesh. The paper discusses the consumer behavior of Bangladeshi consumers in choosing products in terms of health benefits. The paper is an original work of the author and all the secondary data were taken are given credits properly.