bluuebunny/crossref_metadata_2025 huggingface dataset:
Wearable Electrospun Piezoelectric Mats Based on a PVDF Nanofiber–ZnO@ZnS Core–Shell Nanoparticles Composite for Power Generation
Authors: Ali Nehal , Kenawy El-Refaie , Wadoud A. A. , Elhadary M. I.
Published: October 2023

This work adopted a strategy to use new functional high-performance piezoelectric materials for sustainable energy production in wearable self-powered electrical devices. An innovative modification in electrospinning was used to produce highly aligned nanofibers. In the nanogenerator, the flexible membrane constituents were tunefully combined. The novel composite nanofibers were made of Poly (vinylidene fluoride) PVDF, loaded with ZnO@ZnS core–shell nanoparticles to achieve a non-brittle performance of the hetero nanoparticles and piezoelectric polymer. A nanofiber mat was inserted between two thermoplastic sheets with conductive electrodes for application in wearable electronic devices. Complete spectroscopic analyses were performed to characterize the nanofiber’s material composition. It is shown that the addition of 10 wt % ZnO@ZnS core–shell nanoparticles significantly improved the piezoelectric properties of the nanofibers and simultaneously kept them flexible due to the exceedingly resilient nature of the composite. The superior performance of the piezoelectric parameter of the nanofibrous mats was due to the crystallinity (polar β phase) and surface topography of the mat. The conversion sensitivity of the PVDF device recorded almost 0.091 V/N·mm3, while that of the PVDF—10 wt % ZnO@ZnS composite mat recorded a sensitivity of 0.153 V/N·mm3, which is higher than many flexible nano-generators. These nanogenerators provide a simple, efficient, and cost-effective solution to microelectronic wearable devices.
Transition of Carbon Nanotube Sheets from Hydrophobicity to Hydrophilicity by Facile Electrochemical Wetting
Authors: Oh Myoungeun , Seo Hyunji , Choi Jimin , Noh Jun Ho , Kim Juwan , Jeon Joonhyeon , Choi Changsoon
Published: October 2023

The present study delves into the transformative effects of electrochemical oxidation on the hydrophobic-to-hydrophilic transition of carbon nanotube (CNT) sheets. The paper elucidates the inherent advantages of CNT sheets, such as high electrical conductivity and mechanical strength, and contrasts them with the limitations posed by their hydrophobic nature. A comprehensive investigation is conducted to demonstrate the efficacy of electrochemical oxidation treatment in modifying the surface properties of CNT sheets, thereby making them hydrophilic. The study reveals that the treatment not only is cost-effective and time-efficient compared to traditional plasma treatment methods but also results in a significant decrease in water contact angle. Mechanistic insights into the hydrophilic transition are provided, emphasizing the role of oxygen-containing functional groups introduced during the electrochemical oxidation process.
Emerging Mesoporous Polyacrylamide/Gelatin–Iron Lanthanum Oxide Nanohybrids towards the Antibiotic Drugs Removal from the Wastewater
Authors: Parveen Nazish , Alqahtani Fatimah Othman , Alsulaim Ghayah M. , Alsharif Shada A. , Alnahdi Kholoud M. , Alali Hasna Abdullah , Ahmad Mohamad M. , Ansari Sajid Ali
Published: October 2023

The polyacrylamide/gelatin–iron lanthanum oxide (P-G-ILO nanohybrid) was fabricated by the free radical grafting co-polymerization technique in the presence of N,N-methylenebisacrylamide (MBA) as cross linker and ammonium persulfate (APS) as initiator. The P-G-ILO nanohybrid was characterized by the various spectroscopic and microscopic techniques that provided the information regarding the crystalline behavior, surface area, and pore size. The response surface methodology was utilized for the statistical observation of diclofenac (DF) adsorption from the wastewater. The adsorption capacity (qe, mg/g) of P-G-ILO nanohybrid was higher (254, 256, and 258 mg/g) than the ILO nanoparticle (239, 234, and 233 mg/g). The Freundlich isotherm model was the best fitted, as it gives the higher values of correlation coefficient (R2 = 0.982, 0.991 and 0.981) and lower value of standard error of estimate (SEE = 6.30, 4.42 and 6.52), which suggested the multilayered adsorption of DF over the designed P-G-ILO nanohybrid and followed the pseudo second order kinetic model (PSO kinetic model) adsorption. The thermodynamic study reveals that adsorption was spontaneous and endothermic in nature and randomness onto the P-G-ILO nanohybrids surface increases after the DF adsorption. The mechanism of adsorption of DF demonstrated that the adsorption was mainly due to the electrostatic interaction, hydrogen bonding, and dipole interaction. P-G-ILO nanohybrid was reusable for up to five adsorption/desorption cycles.
Discovery of Novel miRNAs in Colorectal Cancer: Potential Biological Roles and Clinical Utility
Authors: Minutentag Iael Weissberg , Seneda Ana Laura , Barros-Filhos Mateus C. , de Carvalho Márcio , Souza Vanessa G. P. , Hasimoto Claudia N. , Moraes Marcelo P. T. , Marchi Fabio A. , Lam Wan L. , Reis Patricia P. , Drigo Sandra A.
Published: October 2023

Deregulated miRNAs are associated with colorectal cancer (CRC), with alterations depending on the tumor location. Novel tissue-specific miRNAs have been identified in different tumors and are associated with cancer. We used miRMaster to identify novel miRNAs in CRC from the TCGA and GEO data (discovery and validation groups). We used TCGA data from five tissues to analyze miRNA tissue specificity. miRDB was used to predict miRNA targets, and the UCSC Xena Browser was used to evaluate target expression. After successive analyses, we identified 15 novel miRNAs with the same expression patterns in CRC in both the discovery and validation groups. Four molecules (nov-miR-13844-5p, nov-miR-7154-5p, nov-miR-5035-3p, and nov-miR-590-5p) were differentially expressed in proximal and distal CRC. The nov-miR-3345-5p and nov-miR-13172-3p, which are upregulated in tumors, are only expressed in colorectal tissues. These molecules have been linked to a worse prognosis in right-sided colon and rectal carcinomas. An analysis revealed an association between eight novel miRNAs and 81 targets, mostly cancer-related genes, with varying expression based on tumor location. These findings provide new miRNAs with potential biological relevance, molecular biomarkers, and therapeutic targets for CRC treatment.
Early Introduction of Novel and Less-Studied Food Allergens in the Plant-Based Era: Considerations for US and EU Infant Formula Regulations
Authors: Venter Carina , Shamir Raanan , Fleischer David Mark
Published: October 2023

Early life feeding practices may affect the long-term health of individuals, particularly in terms of the development of non-communicable diseases, such as metabolic and allergic diseases. Accumulating evidence suggests that the interplay of breastfeeding and/or formula feeding followed by the introduction of solids plays a role in the occurrence of non-communicable diseases both in the short and long term. International food allergy guidelines recommend that breastfeeding women do not need to avoid food allergens and do not recommend any infant formula for allergy prevention. Guidelines regarding solid food introduction for food allergy prevention recommend the introduction of well-cooked eggs and peanuts around 4–6 months of age, and not to delay the introduction of other food allergens. There is also an increasing trend to feed infants a plant-based or plant-forward diet and have access to infant formulas based on plant-based ingredients. The use of novel plant-based infant formulas raises a few questions reviewed in this paper: (1) Do fortified, plant-based infant formulas, compliant with US Food and Drug Administration (FDA) regulations and European Food Safety Authority (EFSA) (European) guidelines, support adequate infant growth? (2) Are plant-based infant formulas suitable for the management of cow’s milk allergy? (3) Does feeding with novel, plant-based infant formulas increase the risk of food allergies to the food allergens they contain? (4) Does feeding infants plant-based food allergens in early life increase the risk of allergic and severe allergic reactions? The review of the literature indicated that (1) plant-based formulas supplemented with amino acids and micronutrients to comply with FDA regulations and EFSA guidelines, evaluated in sufficiently powered growth studies, can support adequate growth in infants; (2) currently available plant-based infant formulas are suitable for the management of CMA; (3) an early introduction and continuous intake of food allergens are more likely to prevent food allergies than to increase their risk; and (4) an early introduction of food allergens in young infants is safe.
Influence of Fluid Ingestion on Heart Rate, Cardiac Autonomic Modulation and Blood Pressure in Response to Physical Exercise: A Systematic Review with Meta-Analysis and Meta-Regression
Authors: Porto Andrey A. , Benjamim Cicero Jonas R. , da Silva Sobrinho Andressa Crystine , Gomes Rayana Loch , Gonzaga Luana A. , da Silva Rodrigues Guilherme , Vanderlei Luiz Carlos Marques , Garner David M. , Valenti Vitor E.
Published: October 2023

A systematic review was undertaken to investigate the involvement of hydration in heart rate (HR), HR variability (HRV) and diastolic (DBP) and systolic (SBP) blood pressure in response to exercise. Data synthesis: The EMBASE, MEDLINE, Cochrane Library, CINAHL, LILACS and Web of Science databases were searched. In total, 977 studies were recognized, but only 36 were included after final screening (33 studies in meta-analysis). This study includes randomized controlled trials (RCTs) and non-RCTs with subjects > 18 years old. The hydration group consumed water or isotonic drinks, while the control group did not ingest liquids. For the hydration protocol (before, during and after exercise), the HR values during the exercise were lower compared to the controls (−6.20 bpm, 95%CI: −8.69; −3.71). In the subgroup analysis, “water ingested before and during exercise” showed lower increases in HR during exercise (−6.20, 95%CI: 11.70 to −0.71), as did “water was ingested only during exercise” (−6.12, 95%CI: −9.35 to −2.89). Water intake during exercise only revealed a trend of avoiding greater increases in HR during exercise (−4,60, 95%CI: −9.41 to 0.22), although these values were not significantly different (p = 0.06) from those of the control. “Isotonic intake during exercise” showed lower HRs than the control (−7.23 bpm, 95% CI: −11.68 to −2.79). The HRV values following the exercise were higher in the hydration protocol (SMD = 0.48, 95%CI: 0.30 to 0.67). The values of the SBP were higher than those of the controls (2.25 mmHg, 95%CI: 0.08 to 4.42). Conclusions: Hydration-attenuated exercise-induced increases in HR during exercise, improved autonomic recovery via the acceleration of cardiac vagal modulation in response to exercise and caused a modest increase in SBP values, but did not exert effects on DBP following exercise.
Breastfeeding Self-Efficacy, Personal Well-Being and Related Factors in Pregnant Women Living in a District of Istanbul
Authors: Değer Mehmet Sait , Sezerol Mehmet Akif , Altaş Zeynep Meva
Published: October 2023

In this study, we examined breastfeeding self-efficacy levels, well-being and sociodemographic factors in pregnant women. The population of this descriptive study consisted of women with a pregnancy of 27 weeks or more in the Sultanbeyli district of Istanbul, Türkiye. A questionnaire was administered via telephone calls to pregnant women aged 18 years and older. The first part of the questionnaire included questions regarding breastfeeding history and sociodemographic information. The second part included the Prenatal Breastfeeding Self-Efficacy Scale, and the last part included the Personal Well-Being Scale. Higher scale scores indicate higher levels of self-efficacy and well-being. In total, 385 women participated in the study. The median age of the pregnant women was 28.0 years (18.0–43.0). The median gestational week was 33.0 (27.0–42.0). Among women who had received breastfeeding counseling, those with a higher level of knowledge about breastfeeding had higher breastfeeding self-efficacy (p < 0.05). Women with better economic status also had higher well-being scores (p < 0.05). There was a positive correlation between well-being and breastfeeding self-efficacy approaching the statistical significance level (p = 0.052). It is important to consider factors that may be associated with women’s well-being and self-efficacy.
The “Planning Health in School” Programme (PHS-pro) to Improve Healthy Eating and Physical Activity: Design, Methodology, and Process Evaluation
Authors: Vieira Margarida , Carvalho Graça S.
Published: October 2023

Few interventions have successfully promoted healthy eating and active living among children with effective changes in anthropometric health outcomes. Well-designed interventions involving multiple strategies to convert the knowledge already available into action are needed for preventing childhood obesity. In this study, an educational programme called “Planning Health in School” (PHS-pro) was designed, implemented and evaluated to contribute to the prevention of obesity in childhood. The PHS-pro aimed at improving the eating behaviours and lifestyles of Portuguese grade-6 children towards healthier nutritional status. This paper describes and evaluates the PHS-pro concerning: (i) the research design within the theoretical framework grounded on “The Transtheoretical Model” and the stages of change; (ii) the educational components and the application of the participatory methodology to engage children to meet their needs, as active participants in their change process; and (iii) the process evaluation of the intervention. The implementation of the PHS-pro took into account the views and inputs of the participants for evaluating the educational components that should be considered in the designing of interventions aiming to be effective strategies. From the health promotion perspective, this study is important because it examines new approaches and pathways to effectively prevent overweight and obesity in children.
Lipid Disturbances in Breast Cancer Patients during Chemotherapy
Authors: Alimperti Aikaterini , Alikari Victoria , Tsironi Maria , Rojas Gil Andrea Paola , Papageorgiou Dimitrios , Kolovos Petros , Panagiotou Aspasia , Panoutsopoulos George I. , Lavdaniti Maria , Zyga Sofia
Published: October 2023

Breast cancer is the most common cancer in women. Cardiovascular diseases are common complications after chemotherapy due to the effect of the drug on lipid levels. This study aimed to explore the changes in lipid profiles in patients with breast cancer under chemotherapy. Methods: In this prospective study, 50 patients with breast cancer participated. Three biochemical–lipid hematological tests were performed: total cholesterol (TC), triglycerides (TGs), High-Density Lipoprotein (HDL-C), and Low-Density Lipoprotein (LDL-C) before initiation (pre-chemotherapy), at the start (first follow-up), and at the completion (second follow-up) of the first cycle of chemotherapy. Statistical significance was set at p < 0.05. Analyses were conducted using SPSS Statistical Software (version 22.0). Results: Mean TC values increased significantly at second follow-up. TGs values decreased significantly from first to second follow-up. HDL-C was significantly lower at first follow-up compared with pre-chemotherapy and was similar to the pre-chemotherapy levels at second follow-up. LDL-C values were significantly higher at second follow-up compared with pre-chemotherapy measurement. Significantly positive correlations of BMI with pre-chemotherapy LDL-C, first follow-up TC, first follow-up LDL-C, second follow-up TC, and second follow-up LDL-C were found. Conclusions: There is a statistically significant increase in the levels of TC and LDL-C in breast cancer patients during chemotherapy. This study was not registered.
Significance of Direct and Indirect Impacts of Temperature Increase Driven by Climate Change on Threat to Oilseed Rape Posed by Sclerotinia sclerotiorum
Authors: Wójtowicz Marek , Wójtowicz Andrzej
Published: October 2023

Sclerotinia stem rot, caused by Sclerotinia sclerotiorum, threatens oilseed rape (Brassica napus) crops internationally. The development of this disease is strongly controlled by the weather, which is why global climate change is likely to influence its spread and impact. Climate change may affect the pathogen directly or indirectly via the host plant. This study investigates the potential impact of climate warming on Sclerotinia stem rot severity in oilseed rape in Poland. The aim of this investigation was to assess the relationship between the direct impact (DI) and indirect impact (II) of climate change on disease severity using the 4.5 and 8.5 representative concentration pathways (RCPs). Under the RCP4.5 scenario, nearly 60% of the simulations performed for 16 regions in four periods (2020–2039, 2040–2059, 2060–2079, 2080–2099) showed reductions in disease severity in comparison to those conducted for 1986–2005, while under RCP 8.5, this reduction was generated for nearly 90% of the cases. The effect of the RCP scenario on clustering the regions according to the value of Sclerotinia stem rot severity was also investigated. The simulations revealed that, for all periods, the lowest disease severities are expected for Zachodniopomorskie and Pomorskie. The results obtained also show the superior effects of the II over the DI on Sclerotinia stem rot severity in the future. Under the RCP4.5 scenario, the rate of IIs was greater than that of DIs for 10 regions, while under RCP8.5, this relationship was registered for 16 regions. These outcomes result from the acceleration of the oilseed rape flowering period triggered by expected temperature increases. The novelty of this study lies in a detailed analysis of the relationships between the DI and II of climate change, expressed numerically, for 16 regions in Poland. The obtained results highlight the role of the indirect impact in shaping disease severity and indicate that it should be incorporated into assessment methods of climate change effects alongside the direct impact.
Pharmacological Studies of Medicinal Potential Phytochemicals in Plant Roots
Authors: Stompor-Gorący Monika
Published: October 2023

Despite various limitations, there is a growing interest in the development of phytomedicine as an alternative therapeutic method, which uses herbal preparations exerting a positive effect on the human immune system and supporting conventional therapies [...]
The Effect of Compression Pressure on the First Layer Surface Roughness and Delamination of Metformin and Evogliptin Bilayer and Trilayer Tablets
Authors: Kim Sun Ho , Kook Jung Han , Seo Dong-Wan , Kang Myung Joo
Published: October 2023

The objectives of this study were to evaluate the delamination of convex-shaped metformin HCl (MF) and evogliptin tartrate (EG) multi-layer tablets depending on the pre-compression and main compression pressures and simultaneously correlate these results with those of a surface roughness analysis. Free-flowing MF and EG (median diameters of 38.3 and 44.7 μm, respectively) granules prepared using the wet granulation method were pre-compressed and subsequently compressed into bilayer and trilayer tablets using a universal testing machine. The compaction force required to break the tablets increased linearly as the main compression pressure increased (30–150 MPa). Conversely, the interfacial strength and compaction breaking force decreased as the pre-compression pressure increased (10–110 MPa). A surface roughness analysis employing a profilometer revealed that the first layer (MF) roughness drastically decreased from 5.89 to 0.51 μm (Ra, arithmetic average of profile height deviations from the mean line) as the pre-compression pressure increased from 10 to 150 MPa in the bilayer tablet. Accordingly, the decrease in the roughness of the first layer reduced the inter-penetration at the interface, as observed via energy dispersive spectrometer (EDS)-equipped scanning electron microscopy, decreasing the interfacial bonding strength and causing delamination of the MF/EG multi-layer tablets. These findings indicate the significance of roughness control in the actual preparation of multi-layer tablets and the usefulness of profilometer- and EDS-based surface analyses for interpreting the delamination of multi-layer tablets.
In Vitro and In Vivo Effects of Synthesis Novel Phenoxyacetamide Derivatives as Potent Apoptotic Inducer against HepG2 Cells through PARP-1 Inhibition
Authors: Sayed Mai M. , Nabil Zohour I. , El-Shenawy Nahla S. , Al-Eisa Rasha A. , Nafie Mohamed S.
Published: October 2023

To discover potential cytotoxic agents, new semi-synthetic phenoxy acetamide derivatives, compound I and compound II, were synthesized, characterized, and screened for their cytotoxic activity against breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The two compounds were more promising against HepG2 than the MCF-7 cell line according to IC50 values. When tested against the HepG2 cell line, compound I, and compound II both had significantly increased cytotoxic activity when compared to the reference medication 5-Fluorouracil (5-FU), with IC50 values of 1.43 M, 5.32 M, and 6.52 M for compound 1, 5-FU and compound II, respectively. Also, compound I displayed a degree of selectivity towards cancer cells compared to normal cells. Compound I significantly enhanced HepG2 total apoptotic cell death by about a 24.51-fold increase. According to cell cycle analysis, compound I induced the arrest of the cell cycle phases G1/S and blocked the progression of the HepG2 cells. Applying the RT-PCR technique achieved a highly significant upregulation in pro-apoptotic genes. The anti-apoptotic gene was significantly downregulated. There was an intrinsic and extrinsic pathway, but the intrinsic pathway was the dominant one. Tumor growth suppression as measured by tumor weight and volume and other hematological, biochemical, and histopathological analyses confirmed the efficacy of compound I as an anticancer agent in vivo examination. Finally, the molecular docking study revealed that compound I was properly docked inside the binding site of PARP-1 protein with stable binding energies and interactive binding modes. Therefore, compound I shows promise as a selective anti-cancer derivative for the treatment of liver cancer after more investigations and clinical studies. This selectivity is a favorable characteristic in the developing cytotoxic agents for cancer treatment, as it indicates a potential for reduced harm to health tissues.
Impact of Chitosan-Based Foliar Application on the Phytochemical Content and the Antioxidant Activity in Hemp (Cannabis sativa L.) Inflorescences
Authors: Beleggia Romina , Iannucci Anna , Menga Valeria , Quitadamo Filippo , Suriano Serafino , Citti Cinzia , Pecchioni Nicola , Trono Daniela
Published: October 2023

In the present study, the phytochemical content and the antioxidant activity in the inflorescences of the monoecious hemp cultivar Codimono grown in southern Italy were assessed, and their elicitation was induced by foliar spray application of 50 mg/L and 250 mg/L of chitosan (CHT) at three different molecular weights (low, CHT L; medium, CHT M; high CHT H). The analysis of the phytochemical profile confirmed that cannabinoids were the most abundant class (54.2%), followed by flavonoids (40.3%), tocopherols (2.2%), phenolic acids (1.9%), and carotenoids (1.4%). Cannabinoids were represented almost exclusively by cannabidiol, whereas cannabigerol and Δ9-tetrahydrocannabinol were detected at very low levels (the latter was below the legal limit of 0.3%). The most abundant flavonoids were orientin and vitexin, whereas tocopherols were mainly represented by α-tocopherol. The antioxidant activity was found to be positively correlated with flavonoids and tocopherols. Statistical analysis revealed that the CHT treatments significantly affected the phytochemical content and the antioxidant activity of hemp inflorescences. Notably, a significant increase in the total phenolic content (from +36% to +69%), the α-tocopherol (from +45% to +75%) and β+γ-tocopherol (from +35% to +82%) contents, and the ABTS radical scavenging activity (from +12% to +28%) was induced by all the CHT treatments. In addition, treatments with CHT 50 solutions induced an increase in the total flavonoid content (from +12% to +27%), as well as in the vitexin (from +17% to +20%) and orientin (from +20% to +30%) contents. Treatment with CHT 50 L almost always resulted in the greatest increases. Overall, our findings indicated that CHT could be used as a low-cost and environmentally safe elicitor to improve the health benefits and the economic value of hemp inflorescences, thus promoting their employment in the food, pharmaceutical, nutraceutical, and cosmetic supply chains.
Genome-Wide Identification of the Trihelix Transcription Factor Family and Functional Analysis of the Drought Stress-Responsive Genes in Melilotus albus
Authors: Zhai Qingyan , Li Hang , Wei Na , Zhang Jiyu , Liu Wenxian
Published: October 2023

The trihelix gene family is a plant-specific family of transcription factors that play an important role in many metabolic pathways, including plant growth and development and stress responses. Drought stress is a major factor limiting the distribution and yield of Melilotus albus. However, the distribution of this gene family in M. albus and its biological functions in response to drought stress have not been reported. To investigate the responses of functional genes to drought stress in M. albus, in this study, a total of 34 MaGTs were identified and characterized, of which 32 MaGT proteins were predicted to be nuclear-localized. Based on conserved motif and phylogenetic analyses, the MaGTs could be divided into five subgroups (GT-1, GT-2, SH4, GT-γ, SIP1). Seven potential candidate genes for drought tolerance were screened and identified via qRT–PCR based on a transcriptome data analysis of drought stress in M. albus. The results indicated that MaGT17 was not only significantly upregulated in the roots after 24 h of drought stress, but also showed a significant induction in the shoots. This finding further confirms that MaGT17 is capable of responding to drought stress in M. albus. Taken together, these results will offer essential insights for understanding the underlying molecular mechanisms of the trihelix proteins and useful data for further research on the growth, development and stress responses of trihelix proteins in M. albus.
The Impact of Structural Variations and Coating Techniques on the Microwave Properties of Woven Fabrics Coated with PEDOT:PSS Composition
Authors: Rubežienė Vitalija , Varnaitė-Žuravliova Sandra , Sankauskaitė Audronė , Pupeikė Julija , Ragulis Paulius , Abraitienė Aušra
Published: October 2023

Minimizing the impact of electromagnetic radiation (EMR) holds paramount importance in safeguarding individuals who frequently utilize electrical and electronic devices. Electrically conductive textiles, which possess specialized EMR shielding features, present a promising solution to mitigate the risks related to EMR. Furthermore, these textile-based shielding materials could find application as radar-absorbing materials in stealth technology, emphasizing the need for substantial absorption capabilities in shielding mechanisms. In this study, various textile-based materials with an electrically conductive coating that contain the conjugated polymer system poly(3,4-ethylene-dioxythiophene)-polystyrene sulfonate (PEDOT:PSS) were prepared and investigated. The influence of the textile substrate structural parameters, coating deposit, and coating method on their microwave properties—transmission, reflection, and absorption—was investigated. Reflection and transmission measurements were conducted within a frequency range of 2 to 18 GHz. These measurements revealed that, for the tested samples, the shielding properties are determined by the combined effect of reflection and absorption. However, the role of these two parameters varies across the tested frequency range. It was defined that for fabrics coated on one side, better reflection reduction is obtained when the shielding effectiveness (SE) is below |20| dB. It was found that by controlling the coating deposition on the fabric, it is possible to fine-tune the electrical properties to a certain extent, thereby influencing the microwave properties of the coated fabrics. The studies of prepared samples have shown that reflection and transmission parameters depend not only on the type and quantity of conductive paste applied to the fabric but also on the fabric’s construction parameters and the coating technique used. It was found that the denser the substrate used for coating, the more conductive paste solidifies on the surface, forming a thicker coat on the top. For conductive fabrics with the same substrate to achieve a particular SE value using the knife-over-roll coating technology, the required coating deposit amount is considerably lower as compared with the deposit necessary in the case of screen printing: for the knife-over-roll-coated sample to reach SE 15 dB, the required deposit is approximately 14 g/m2; meanwhile, for a sample coated via screen printing, this amount rises to 23 g/m2.
Novel Nanotherapeutic Systems Based on PEGylated Squalene Micelles for Enhanced In Vitro Activity of Methotrexate and Cytarabine
Authors: Craciun Bogdan-Florin , Sandu Isabela-Andreea , Peptanariu Dragos , Pinteala Mariana
Published: October 2023

Nanomedicine has garnered significant attention due to the advantages it offers in the treatment of cancer-related disorders, some of the deadliest diseases affecting human lives. Conventional medication formulations often encounter issues of instability or insolubility in biological environments, resulting in low bioavailability. Nanocarriers play a crucial role in transporting and safeguarding drugs at specific sites of action, enabling gradual release under particular conditions. This study focuses on methotrexate (MTx) and cytarabine (Cyt), essential antitumoral drugs, loaded into PEGylated squalene micellar structures to enhance therapeutic effectiveness and minimize drawbacks. The micelles were prepared using ultrasound-assisted methods in both water and phosphate buffer saline solutions. Evaluation of drug-loaded micelles encompassed parameters such as particle size, colloidal stability, surface charge, morphology, encapsulation efficiency, drug loading capacity, and in vitro release profiles under simulated physiological and tumoral conditions. In vitro cell inhibition studies conducted on MCF-7 and HeLa cell lines demonstrated higher antitumoral activity for the drug-encapsulated micelles compared to free drugs. The encapsulation effectively addressed the burst effect, providing sustained release for at least 48 h while enhancing the drug’s protection under physiological conditions.
Synthesis and Structural Insight into poly(dimethylsiloxane)-b-poly(2-vinylpyridine) Copolymers
Authors: Manesi Gkreti-Maria , Moutsios Ioannis , Moschovas Dimitrios , Papadopoulos Georgios , Ntaras Christos , Rosenthal Martin , Vidal Loic , Ageev Georgiy G. , Ivanov Dimitri A. , Avgeropoulos Apostolos
Published: October 2023

In this study, the use of anionic polymerization for the synthesis of living poly(dimethylsiloxane) or PDMS-Li+, as well as poly(2-vinylpyridine) or P2VP-Li+ homopolymers, and the subsequent use of chlorosilane chemistry in order for the two blocks to be covalently joined leading to PDMS-b-P2VP copolymers is proposed. High vacuum manipulations enabled the synthesis of well-defined materials with different molecular weights (Μ¯n, from 9.8 to 36.0 kg/mol) and volume fraction ratios (φ, from 0.15 to 0.67). The Μ¯n values, dispersity indices, and composition were determined through membrane/vapor pressure osmometry (MO/VPO), size exclusion chromatography (SEC), and proton nuclear magnetic resonance spectroscopy (1H NMR), respectively, while the thermal transitions were determined via differential scanning calorimetry (DSC). The morphological characterization results suggested that for common composition ratios, lamellar, cylindrical, and spherical phases with domain periodicities ranging from approximately 15 to 39 nm are formed. A post-polymerization chemical modification reaction to quaternize the nitrogen atom in some of the P2VP monomeric units in the copolymer with the highest P2VP content, and the additional characterizations through 1H NMR, infrared spectroscopy, DSC, and contact angle are reported. The synthesis, characterization, and quaternization of the copolymer structure are important findings toward the preparation of functional materials with enhanced properties suitable for various nanotechnology applications.
The Potential of Edible Films, Sheets, and Coatings Based on Fruits and Vegetables in the Context of Sustainable Food Packaging Development
Authors: Janowicz Monika , Galus Sabina , Ciurzyńska Agnieszka , Nowacka Małgorzata
Published: October 2023

Several consumable substances, including fruit and vegetable purees, extracts, juices, and plant residue, were analyzed for their matrix-forming potential. These matrices serve as the basis for the production of edible films, sheets, and coatings that can be eaten as nutritional treats or applied to food products, thereby contributing to their overall good quality. Furthermore, this innovative approach also contributes to optimizing the performance of synthetic packaging, ultimately reducing reliance on synthetic polymers in various applications. This article explores the viability of incorporating fruits and vegetables as basic ingredients within edible films, sheets, and coatings. The utilization of fruits and vegetables in this manner becomes achievable due to the existence of polysaccharides and proteins that facilitate the formation of matrices in their makeup. Moreover, including bioactive substances like vitamins and polyphenols can impart attributes akin to active materials, such as antioxidants or antimicrobial agents. Advancing the creation of edible films, sheets, and coatings derived from fruits and vegetables holds great potential for merging the barrier and mechanical attributes of biopolymers with the nutritional and sensory qualities inherent in these natural components. These edible films made from fruits and vegetables could potentially serve as alternatives to seaweed in sushi production or even replace conventional bread, pancakes, tortillas, and lavash in the diet of people suffering from celiac disease or gluten allergy, while fruit and vegetable coatings may be used in fresh and processed food products, especially fruits and vegetables but also sweets.
Experimental Early Stimulation of Bone Tissue Neo-Formation for Critical Size Elimination Defects in the Maxillofacial Region
Authors: Patlataya Nadezhda Nicolaevna , Bolshakov Igor Nicolaevich , Levenets Anatoliy Alexandrovich , Medvedeva Nadezhda Nicolaevna , Khorzhevskii Vladimir Alexeevich , Cherkashina Mariya Arturovna
Published: October 2023

A biomaterial is proposed for closing extensive bone defects in the maxillofacial region. The composition of the biomaterial includes high-molecular chitosan, chondroitin sulfate, hyaluronate, heparin, alginate, and inorganic nanostructured hydroxyapatite. The purpose of this study is to demonstrate morphological and histological early signs of reconstruction of a bone cavity of critical size. The studies were carried out on 84 white female rats weighing 200–250 g. The study group consisted of 84 animals in total, 40 in the experimental group and 44 in the control group. In all animals, three-walled bone defects measuring 0.5 × 0.4 × 0.5 cm3 were applied subperiosteally in the region of the angle of the lower jaw and filled in the experimental group using lyophilized gel mass of chitosan–alginate–hydroxyapatite (CH–SA–HA). In control animals, the bone cavities were filled with their own blood clots after bone trepanation and bleeding. The periods for monitoring bone regeneration were 3, 5, and 7 days and 2, 3, 4, 6, 8, and 10 weeks. The control of bone regeneration was carried out using multiple morphological and histological analyses. Results showed that the following process is an obligatory process and is accompanied by the binding and release of angiogenic implantation: the chitosan construct actively replaced early-stage defects with the formation of full-fledged new bone tissue compared to the control group. By the 7th day, morphological analysis showed that the formation of spongy bone tissue could be seen. After 2 weeks, there was a pronounced increase in bone volume (p < 0.01), and at 6 weeks after surgical intervention, the closure of the defect was 70–80%; after 8 weeks, it was 100% without violation of bone morphology with a high degree of mineralization. Thus, the use of modified chitosan after filling eliminates bone defects of critical size in the maxillofacial region, revealing early signs of bone regeneration, and serves as a promising material in reconstructive dentistry.
Switchable Deep Eutectic Solvents for Lignin Dissolution and Regeneration
Authors: Li Debao , Qi Letian , Yang Mengru , Gu Yujie , Xue Yu , Chen Jiachuan , He Ming , Yang Guihua
Published: October 2023

Deep eutectic solvents (DESs) are promising for lignin dissolution and extraction. However, they usually possess high polarity and are difficult to recycle. To overcome this drawback, a variety of switchable ionic liquids (SILs) composed of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and alcohols was synthesized and screened. According to the thermodynamic modeling suggestions, the selected DBU–HexOH SIL was coupled with hydrogen-bond donors to form switchable-DES (SDES) systems with moderated viscosity, conductivity, and pH while maintaining switchability. The SDESs produced a well-improved lignin and lignin model compound solubility compared with those of SILs; charging CO2 into SDES (SDESCO2) caused a further increase in solubility. The solubility (25 °C) of syringic acid, ferulic acid, and milled wood lignin in SDESCO2 reached 230.57, 452.17, and 279.12 mg/g, respectively. Such SDES-dissolved lignin can be regenerated using acetone as an anti-solvent. The SDES-regenerated lignin exhibited a well-preserved structure with no noticeable chemical modifications. Furthermore, the SDESCO2 lignin possessed a higher molecular weight (Mw = 10,340 g/mol; Mn = 7672 g/mol), improved uniformity (polydispersity index = 1.35), and a higher guaiacyl lignin unit content compared with the original milled wood lignin. The SDES system proposed in the present work could benefit the fractionation of lignin compounds and facilitate downstream industrial processes.
The Gospel of John and Contemporary Society: Three Major Theological Contributions
Authors: Ford David F.
Published: October 2023

The motives for a 20-year project on the Gospel of John, and the approach taken, are described. Then three major contributions to the twenty-first century are explored: first, the essentials of a Christian worldview; second, who Jesus Christ is, and his presence to readers of the Gospel now; and, third, the spirituality of Christian discipleship as one of learning, loving, and praying, encouraging daring improvisation in the Spirit now. The culmination is the potential of John’s wisdom and pedagogy of desire for a wide range of twenty-first century challenges, and an invitation to a Johannine Renaissance today, shaped through the double simplicity of trusting testimony and habitual rereading.
Two Mw ≥ 6.5 Earthquakes in Central Pamir Constrained by Satellite SAR Observations
Authors: Wang Shuai , Song Chuang , Xiao Zhuohui
Published: October 2023

The Pamir, situated in central Asia, is a result of the ongoing northward advance of the Indian continent, leading to compression of the Asian landmass. While geodetic and seismic data typically indicate that the most significant deformation in Pamir is along its northern boundary, an Mw 7.2 earthquake on 7 December 2015 and an Mw 6.8 earthquake on 23 February 2023 have occurred in the remote interior of Pamir. These two Mw ≥ 6.5 earthquakes, with good observations of satellite synthetic aperture radar data, provide a rare opportunity to gain insights into rupture mechanics and deformation patterns in this challenging-to-reach region. Here, we utilize spaceborne synthetic aperture radar data to determine the seismogenic faults and finite slip models for these two earthquakes. Our results reveal that the 2015 earthquake ruptured a ~88 km long, left-lateral strike-slip fault that dips to northwest. The rupture of the 2015 earthquake extended to the ground surface over a length of ~50 km with a maximum slip of ~3.5 m. In contrast, the 2023 earthquake did not rupture the ground surface, with a maximum slip of ~2.2 m estimated at a depth of ~9 km. Notably, the seismogenic fault of the 2015 earthquake does not align with the primary strand of the Sarez–Karakul fault system (SKFS), and the 2023 earthquake occurred on a previously unmapped fault. The well-determined seismogenic faults for the 2015 and 2023 earthquakes, along with the SKFS and other distributed faults in the region, suggest the existence of a wide shear zone extending from south to north within the central Pamir.
Retrieval of an On-Orbit Bidirectional Reflectivity Reference in the Mid-Infrared Bands of FY-3D/MERSI-2 Channels 20
Authors: Peng Bo , Chen Wei , Wang Hengyang , Hu Xiuqing , Tang Hongzhao , Li Guangchao , Zhang Fengjiao
Published: October 2023

The acquisition of high-accuracy reflectance in mid-infrared channels is of great significance for the on-orbit cross-calibration of other bands using the mid-infrared band. However, due to the phenomenon that some sensors have a wide range of wavelengths covered by adjacent channels in the mid-infrared band, the traditional method of estimating the mid-infrared reflectivity assumes that the sea surface reflectivity in different mid-infrared bands is equal, which will lead to a large error during calculation. To solve this problem, this study proposes a nonlinear split-window algorithm involving ocean sun glint data to retrieve reflectivity of FY-3D/MERSI-2 channels 20. The results show that the variation range of sea surface reflectivity of channel 20 in the glint area is 10~25%, the mean value of the reflectivity difference obtained by the nonlinear split-window algorithm is 0.27%, and the RMSE is 0.0066. Among the main influencing factors, the atmospheric conditions have the greatest impact, and the effects of the uncertainties in the water vapor content and aerosol optical thickness on the calculation results are 1.16% and 0.34%, respectively. The initial value limits of the mid-infrared sea surface reflectivity also contribute approximately 0.84%, and their contribution to the uncertainty represents one of the main components. This work shows that the nonlinear split-window algorithm can calculate the infrared sea surface reflectivity with high accuracy and can be used as a reference for in-orbit cross-calibration between different bands.
Spatio-Temporal Characteristics of Ice–Snow Freezing and Its Impact on Subtropical Forest Fires in China
Authors: Wang Xuecheng , Gao Xing , Wu Yuming , Jiang Hou , Wang Peng
Published: October 2023

Ice–snow freezing may disrupt the growth condition and structure of forest vegetation, increasing combustible loads and thus triggering forest fires. China’s subtropical regions are rich in forest resources, but are often disturbed by ice–snow freezing, especially due to climate change. Clarifying the responsive areas and times of forest fires to ice-snow freezing in this region is of vital importance for local forest fire management. In this study, meteorological data from 2001 to 2019 were used to extract the precipitation and its duration during the freezing period in order to analyze the freezing condition of forest vegetation in subtropical China. To improve the accuracy of identifying forest fires, we extracted forest fire information year-by-year and month-by-month based on the moderate resolution imaging spectroradiometer (MODIS) active fire data (MOD14A2) using the enhanced vegetation index (EVI), and analyzed the forest fire clustering characteristics in the region using the Moran’s Index. Then, correlation analysis between forest fires and freezing precipitation was utilized to explore the responsive areas and periods of forest fires caused by ice–snow freezing. Our analysis shows the following: (1) during the period of 2001–2019, the ice–snow freezing of forest vegetation was more serious in Hunan, Jiangxi, Hubei, and Anhui provinces; (2) forest fires in subtropical China have shown a significant downward trend since 2008 and their degree of clustering has been reduced from 0.44 to 0.29; (3) forest fires in Hunan, Jiangxi, and Fujian provinces are greatly affected by ice–snow freezing, and their correlation coefficients are as high as 0.25, 0.25, and 0.32, respectively; and (4) heavy ice–snow freezing can increase forest combustibles and affect forest fire behavior in February and March. This research is valuable for forest fire management in subtropical China and could also provide a reference for other regions.
Machine Learning Downscaling of SoilMERGE in the United States Southern Great Plains
Authors: Tobin Kenneth , Sanchez Aaron , Esparza Daniela , Garcia Miguel , Ganta Deepak , Bennett Marvin
Published: October 2023

SoilMERGE (SMERGE) is a root-zone soil moisture (RZSM) product that covers the entire continental United States and spans 1978 to 2019. Machine learning techniques, Random Forest (RF), eXtreme Gradient Boosting (XGBoost), and Gradient Boost (GBoost) downscaled SMERGE to spatial resolutions straddling the field scale domain (100 to 3000 m). Study area was northern Oklahoma and southern Kansas. The coarse resolution of SMERGE (0.125 degree) limits this product’s utility. To validate downscaled results in situ data from four sources were used that included: United States Department of Energy Atmospheric Radiation Measurement (ARM) observatory, United States Climate Reference Network (USCRN), Soil Climate Analysis Network (SCAN), and Soil moisture Sensing Controller and oPtimal Estimator (SoilSCAPE). In addition, RZSM retrievals from NASA’s Airborne Microwave Observatory of Subcanopy and Surface (AirMOSS) campaign provided a nearly spatially continuous comparison. Three periods were examined: era 1 (2016 to 2019), era 2 (2012 to 2015), and era 3 (2003 to 2007). During eras 1 and 2, RF outperformed XGBoost and GBoost, whereas during era 3 no model dominated. Performance was better during eras 1 and 2 as opposed to the pre-L band era 3. Improvements across all eras, regions, and models realized from downscaling included an increase in correlation from 0.03 to 0.42 and a decrease in ubRMSE from −0.0005 to −0.0118 m3/m3. This study demonstrates the feasibility of SMERGE downscaling opening the prospect for the development of a long-term RZSM dataset at a more desirable field-scale resolution with the potential to support diverse hydrometeorological and agricultural applications.
Identifying Winter Wheat Using Landsat Data Based on Deep Learning Algorithms in the North China Plain
Authors: Zhang Qixia , Wang Guofu , Wang Guojie , Song Weicheng , Wei Xikun , Hu Yifan
Published: October 2023

The North China Plain (NCP) represents a significant agricultural production region in China, with winter wheat serving as one of its main grain crops. Accurate identification of winter wheat through remote sensing technology holds significant importance in ensuring food security in the NCP. In this study, we have utilized Landsat 8 and Landsat 9 imagery to identify winter wheat in the NCP. Multiple convolutional neural networks (CNNs) and transformer networks, including ResNet, HRNet, MobileNet, Xception, Swin Transformer and SegFormer, are used in order to understand their uncertainties in identifying winter wheat. At the same time, these deep learning (DL) methods are also compared to the traditional random forest (RF) method. The results indicated that SegFormer outperformed all methods, of which the accuracy is 0.9252, the mean intersection over union (mIoU) is 0.8194 and the F1 score (F1) is 0.8459. These DL methods were then applied to monitor the winter wheat planting areas in the NCP from 2013 to 2022, and the results showed a decreasing trend.