bluuebunny/crossref_metadata_2025 huggingface dataset:
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
Authors: Manjula Ramu , Anuja Kumari , Alcain Francisco J.
Published: January 2021

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They play a prominent role in many aspects of physiology and regulate crucial proteins. Modulation of sirtuins can thus be utilized as a therapeutic target for metabolic disorders. Neurological diseases have distinct clinical manifestations but are mainly age-associated and due to loss of protein homeostasis. Sirtuins mediate several life extension pathways and brain functions that may allow therapeutic intervention for age-related diseases. There is compelling evidence to support the fact that SIRT1 and SIRT2 are shuttled between the nucleus and cytoplasm and perform context-dependent functions in neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). In this review, we highlight the regulation of SIRT1 and SIRT2 in various neurological diseases. This study explores the various modulators that regulate the activity of SIRT1 and SIRT2, which may further assist in the treatment of neurodegenerative disease. Moreover, we analyze the structure and function of various small molecules that have potential significance in modulating sirtuins, as well as the technologies that advance the targeted therapy of neurodegenerative disease.
Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation
Authors: Verkerk Arie O. , Knottnerus Suzan J. G. , Portero Vincent , Bleeker Jeannette C. , Ferdinandusse Sacha , Guan Kaomei , IJlst Lodewijk , Visser Gepke , Wanders Ronald J. A. , Wijburg Frits A. , Bezzina Connie R. , Mengarelli Isabella , Houtkooper Riekelt H.
Published: January 2021

Patients with a deficiency in very long-chain acyl-CoA dehydrogenase (VLCAD), an enzyme that is involved in the mitochondrial beta-oxidation of long-chain fatty acids, are at risk for developing cardiac arrhythmias. In human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), VLCAD deficiency (VLCADD) results in a series of abnormalities, including: 1) accumulation of long-chain acylcarnitines, 2) action potential shortening, 3) higher systolic and diastolic intracellular Ca2+concentrations, and 4) development of delayed afterdepolarizations. In the fatty acid oxidation process, carnitine is required for bidirectional transport of acyl groups across the mitochondrial membrane. Supplementation has been suggested as potential therapeutic approach in VLCADD, but its benefits are debated. Here, we studied the effects of carnitine supplementation on the long-chain acylcarnitine levels and performed electrophysiological analyses in VLCADD patient-derived hiPSC-CMs with aACADVLgene mutation (p.Val283Ala/p.Glu381del). Under standard culture conditions, VLCADD hiPSC-CMs showed high concentrations of long-chain acylcarnitines, short action potentials, and high delayed afterdepolarizations occurrence. Incubation of the hiPSC-CMs with 400 µM L-carnitine for 48 h led to increased long-chain acylcarnitine levels both in medium and cells. In addition, carnitine supplementation neither restored abnormal action potential parameters nor the increased occurrence of delayed afterdepolarizations in VLCADD hiPSC-CMs. We conclude that long-chain acylcarnitine accumulation and electrophysiological abnormalities in VLCADD hiPSC-CMs are not normalized by carnitine supplementation, indicating that this treatment is unlikely to be beneficial against cardiac arrhythmias in VLCADD patients.
Resistance Distances in Linear Polyacene Graphs
Authors: Wang Dayong , Yang Yujun
Published: January 2021

The resistance distance between any two vertices of a connected graph is defined as the net effective resistance between them in the electrical network constructed from the graph by replacing each edge with a unit resistor. In this article, using electric network approach and combinatorial approach, we derive exact expression for resistance distances between any two vertices of polyacene graphs.
The Impact of Polyphenols-Based Diet on the Inflammatory Profile in COVID-19 Elderly and Obese Patients
Authors: Santos Juliana Carvalho , Ribeiro Marcelo Lima , Gambero Alessandra
Published: January 2021

The World Health Organization declared the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated disease (coronavirus disease 2019 – COVID-19) as a pandemic in March 2020. COVID-19 is characterized by cytokine storm, acute respiratory distress syndrome (ARDS), and systemic inflammation–related pathology and already kills more than 1.5 million of people worldwide. Since aged and obese COVID-19 patients exhibit an enhanced inflammatory status, they represent a high-risk cluster for rapidly progressive clinical deterioration. These individuals present comorbid disorders and immunosenescence that may promote viral-induced cytokine storm and expression of molecules acting as virus receptor as angiotensin I converting enzyme 2 (ACE2) and CD26 (dipeptidyl-peptidase 4), resulting in respiratory failure and increased morbidity and mortality. A better knowledge of SARS-CoV-2 infection in inflammatory-associated high-risk population is essential in order to develop the therapies needed to combat or prevent severe COVID-19. Here, we review the pathogenesis and clinical implications of inflammatory disorders and disease markers associated to senescence in COVID-19 patients and the emerging evidence to argue that a high intake of polyphenols may have a protective effect on SARS-CoV-2 illness severity.
Searching for Errors in Models of Complex Dynamic Systems
Authors: Kahl Dominik , Kschischo Maik
Published: January 2021

Mathematical modeling is seen as a key step to understand, predict, and control the temporal dynamics of interacting systems in such diverse areas like physics, biology, medicine, and economics. However, for large and complex systems we usually have only partial knowledge about the network, the coupling functions, and the interactions with the environment governing the dynamic behavior. This incomplete knowledge induces structural model errors which can in turn be the cause of erroneous model predictions or misguided interpretations. Uncovering the location of such structural model errors in large networks can be a daunting task for a modeler. Here, we present a data driven method to search for structural model errors and to confine their position in large and complex dynamic networks. We introduce a coherence measure for pairs of network nodes, which indicates, how difficult it is to distinguish these nodes as sources of an error. By clustering network nodes into coherence groups and inferring the cluster inputs we can decide, which cluster is affected by an error. We demonstrate the utility of our method for theC. elegansneural network, for a signal transduction model for UV-B light induced morphogenesis and for synthetic examples.
Into Your (S)Kin: Toward a Comprehensive Conception of Empathy
Authors: Søvsø Tue Emil Öhler , Burckhardt Kirstin
Published: January 2021

This paper argues for a comprehensive conception of empathy as comprising epistemic, affective, and motivational elements and introduces the ancient Stoic theory of attachment (Greek,oikeiōsis) as a model for describing the embodied, emotional response to others that we take to be distinctive of empathy. Our argument entails that in order to provide a suitable conceptual framework for the interdisciplinary study of empathy one must extend the scope of recent “simulationalist” and “enactivist” accounts of empathy in two important respects. First, against the enactivist assumption that human mindreading capacities primarily rely on an immediate, quasi-perceptual understanding of other’s intentional states, we draw on Alfred Schutz’ analysis of social understanding to argue that reflective types of understanding play a distinct, but equally fundamental role in empathic engagements. Second, we insist that empathy also involves an affective response toward the other and their situation (as the empathizer perceives this). We suggest analyzing this response in terms of the Stoic concepts of attachment, concern, and a fundamental type of prosocial motivation, that can best be described as an “extended partiality.” By way of conclusion, we integrate the above concepts into a comprehensive conceptual framework for the study of empathy and briefly relate them to current debates about empathic perception and prosocial motivation. The result, we argue, is an account that stays neutral with regard to the exact nature of the processes involved in producing empathy and can therefore accommodate discussion across theoretical divides—e.g., those between enactivist, simulationalist, and so-called theory-theorist approaches.
A Comparison of Conventional and Technology-Mediated Selection Interviews With Regard to Interviewees’ Performance, Perceptions, Strain, and Anxiety
Authors: Melchers Klaus G. , Petrig Amadeus , Basch Johannes M. , Sauer Juergen
Published: January 2021

Organizations increasingly use technology-mediated interviews. However, only limited research is available concerning the comparability of different interview media and most of the available studies stem from a time when technology-mediated interviews were less common than in the present time. In an experiment using simulated selection interviews, we compared traditional face-to-face (FTF) interviews with telephone and videoconference interviews to determine whether ratings of interviewees’ performance, their perceptions of the interview, or their strain and anxiety are affected by the type of interview. Before participating in the actual interview, participants had a more positive view of FTF interviews compared to technology-mediated interviews. However, fairness perceptions did not differ anymore after the interview. Furthermore, there were no differences between the three interview media concerning psychological and physiological indicators of strain or interview anxiety. Nevertheless, ratings of interviewees’ performance were lower in the technology-mediated interviews than in FTF interviews. Thus, differences between different interview media can still be found nowadays even though most applicants are much more familiar with technology-mediated communication than in the past. The results show that organizations should take this into account and therefore avoid using different interview media when they interview different applicants for the same job opening.
Toward a Contextually Valid Assessment of Partner Violence: Development and Psycho-Sociometric Evaluation of the Gendered Violence in Partnerships Scale (GVPS)
Authors: Goessmann Katharina , Ibrahim Hawkar , Saupe Laura B. , Neuner Frank
Published: January 2021

This article presents a new measure for intimate partner violence (IPV), the Gendered Violence in Partnerships Scale (GVPS). The scale was developed in the Middle East with the aim to contribute to the global perspective on IPV by providing a contextual assessment tool for partner violence against women in violent-torn settings embedded in a patriarchal social structure. In an effort to generate a scale including IPV items relevant to the women of the population, a pragmatic step-wise procedure, with focus group discussions and expert panels, was performed. The study’s analyses resulted in an 18-item checklist featuring four subscales of the GVPS that are based on a new typology of male-to-female partner violence presenting an alternative to the commonly used classification by type of abuse (i.e., physical, psychological, sexual acts). Therein, dominating behaviors, existential threats, impulsive aggression, and aggravated physical assault were identified as reflective of the lived realities of women in the war-torn Middle East, which was confirmed in factor analysis. The scale’s psychometric properties were assessed with data from 1,009 displaced women in Iraq, and associations with measures of psychopathology were determined. Implications for IPV assessment and prevention possibilities in humanitarian contexts and beyond are discussed.
The Way We See Others in Intercultural Relations: The Role of Stereotypes in the Acculturation Preferences of Spanish and Moroccan-Origin Adolescents
Authors: Urbiola Ana , López-Rodríguez Lucía , Sánchez-Castelló María , Navas Marisol , Cuadrado Isabel
Published: January 2021

Although the relationship between stereotypes and acculturation preferences has been previously studied from the majority perspective among adults, the perspective of adolescents and minority groups is understudied. This research analyzed the contribution of four stereotype dimensions (i.e., morality, immorality, sociability, and competence) to the acculturation preferences of Spanish adolescents and adolescents of Moroccan-origin, the moderating role of stereotypes in intergroup acculturation discrepancies, and the interaction of stereotypes with acculturation perceptions on acculturation preferences. A sample of 488 Spanish adolescents and 360 adolescents of Moroccan-origin living in Spain, from 12 to 19 years old, reported how moral, immoral, social, and competent they perceive each other to be. Spanish adolescents reported their perception about how Moroccan youth were acculturating in terms of maintaining their original culture and adopting the host culture, and their acculturation preferences in the same dimensions. Adolescents of Moroccan-origin reported to what extent they were maintaining their original culture and adopting the host culture, their acculturation preferences, and their ethnic and national (Spanish) identity. Results showed that adolescents of Moroccan-origin reported more positive perceptions of Spanish youth than conversely. The perceived immorality of the outgroup was important for understanding the preferences for adopting the host culture of both groups, but in the opposite direction. The four stereotype dimensions modulated the majority-minority discrepancies in preferences for cultural adoption. An analysis of the interaction between stereotypes and perceived adoption on acculturation preferences showed that when Spanish adolescents perceived that Moroccan youth were not adopting the Spanish culture, perceived morality and sociability played a role in their preferences for adoption. The less moral and sociable Moroccans were perceived, the more preference for cultural adoption. These findings support the importance of considering stereotypes in acculturation studies of majority and minority groups, as well as the relevance of including these perceptions in interventions aimed at improving intercultural relations.
A Novel Test of the Duchenne Marker: Smiles After Botulinum Toxin Treatment for Crow’s Feet Wrinkles
Authors: Etcoff Nancy , Stock Shannon , Krumhuber Eva G. , Reed Lawrence Ian
Published: January 2021

Smiles that vary in muscular configuration also vary in how they are perceived. Previous research suggests that “Duchenne smiles,” indicated by the combined actions of the orbicularis oculi (cheek raiser) and the zygomaticus major muscles (lip corner puller), signal enjoyment. This research has compared perceptions of Duchenne smiles with non-Duchenne smiles among individuals voluntarily innervating or inhibiting the orbicularis oculi muscle. Here we used a novel set of highly controlled stimuli: photographs of patients taken before and after receiving botulinum toxin treatment for crow’s feet lines that selectively paralyzed the lateral orbicularis oculi muscle and removed visible lateral eye wrinkles, to test perception of smiles. Smiles in which the orbicularis muscle was active (prior to treatment) were rated as more felt, spontaneous, intense, and happier. Post treatment patients looked younger, although not more attractive. We discuss the potential implications of these findings within the context of emotion science and clinical research on botulinum toxin.
Competitive Recovery–Stress and Mood States in Mexican Youth Athletes
Authors: Reynoso-Sánchez Luis Felipe , Pérez-Verduzco Germán , Celestino-Sánchez Miguel Ángel , López-Walle Jeanette M. , Zamarripa Jorge , Rangel-Colmenero Blanca Rocío , Muñoz-Helú Hussein , Hernández-Cruz Germán
Published: January 2021

Background

Monitoring recovery–stress balance in sport is becoming more relevant to prevent training maladaptation and reach the optimal performance for each athlete. The use of questionnaires that identify the athlete’s recovery–stress state have much acceptance in sports due to reliability and useful, furthermore for its low cost. Identifying possible differences between sport modalities and sex is important to determine specific needs and possible intervention ways to keep a recovery–stress balance. The aim was to analyze the differences in the recovery–stress state and mood states by sex and sport type during the competitive phase in young Mexican athletes. As a secondary objective, the psychometric properties of the Mexican version of the Recovery–Stress Questionnaire for Athletes (RESTQ-Sport) were analyzed.

Methods

A cross-sectional study was carried on with 461 athletes (61% women and 39% men), 17.95 (±1.2) years old, from six sports disciplines. The RESTQ-Sport and Profile of Mood States (POMS) were applied in a single moment. Differences by sex and sports modality were analyzed. RESTQ-Sport’s confirmatory factor analysis was performed after the stress and recovery theoretical structure of two stress (general and sport) and two recovery (general and sport) dimensions, and last, the concurrent validation with the POMS was carried on.

Results

Significant differences by sex were found in the General Recovery and Sport Stress dimensions of the RESTQ-Sport as well as Vigor factor of the POMS, being higher for men; furthermore, both the Sport Recovery dimension of RESTQ-Sport and Cholera and the Fatigue and Depression factors from POMS also had differences by sport type, showing a less recovery and high stress for individual sport athletes. Goodness-of-fit indexes of the model for the RESTQ-Sport were acceptable. Pearson’s correlation between questionnaires was moderate (p < 0.05).

Conclusion

The recovery–stress state shows differences in the function of sex and sport modality. More special attention is suggested for women and individual sport athletes. The higher punctuation for men compared with women in sport stress dimension did not negatively affect the recovery–stress balance for male athletes. Finally, the Mexican context adaptation of the RESTQ-Sport provides a psychometric instrument suitable to assess the recovery–stress balance in Mexican athletes.
Effect of Increased Cabin Recirculation Airflow Fraction on Relative Humidity, CO2 and TVOC
Authors: Norrefeldt Victor , Mayer Florian , Herbig Britta , Ströhlein Ria , Wargocki Pawel , Lei Fang
Published: January 2021

In the CleanSky 2 ComAir study, subject tests were conducted in the Fraunhofer Flight Test Facility cabin mock-up. This mock-up consists of the front section of a former in-service A310 hosting up to 80 passengers. In 12 sessions the outdoor/recirculation airflow ratio was altered from today’s typically applied fractions to up to 88% recirculation fraction. This leads to increased relative humidity, carbon dioxide (CO2) and Total Volatile Organic Compounds (TVOC) levels in the cabin air, as the emissions by passengers become less diluted by outdoor, dry air. This paper describes the measured increase of relative humidity, CO2 and TVOC level in the cabin air for the different test conditions.
Key Competencies of Agricultural Managers in the Acute Stage of the COVID-19 Crisis
Authors: Jankelová Nadežda , Mišún Juraj
Published: January 2021

The acute phase of the COVID-19 crisis exacerbated the need for managerial skills of agricultural managers, provoked another wave of discussion on content of managerial competencies in times of crisis, and revealed a significant research gap. The main goal of our study is to identify the impact of competencies of agricultural crisis managers on the performance of employees in the acute phase of the crisis, when the performance was influenced by their subjective perception and evaluation of their working conditions, satisfaction and safety. We used statistical mediation to examine the connections and deeper relationships between several variables. The hypothesis of dependence between competencies of crisis management and performance of employees, mediated by information sharing, teamwork and cognitive diversity, has been confirmed. Partial mediation has been identified, when only part of the effect is mediated by the mediator variables, however the substantial one. The remaining, smaller part is transmitted directly. Employees’ performance in an acute crisis phase can be influenced by competent crisis management and enhance its effect through information sharing and teamwork support. The cognitive diversity of crisis management did not prove significant in our study. The emphasis is on consistency and the resulting sense of security and safety.
Interactive Effects of Gibberellic Acid and Nitrogen Fertilization on the Growth, Yield, and Quality of Sugar Beet
Authors: Leilah Ahmed A. A. , Khan Naeem
Published: January 2021

Two field trials were conducted during the 2014/2015 and 2015/2016 seasons at Aweesh Al-Hagar Village, center of Mansoura, Dakahlia Governorate, Egypt. A split-split-plot design with four replicates was used. The main plots were assigned three nitrogen fertilizer levels, i.e., 165, 220, and 275 kg/ha. The sub-plots were restricted to four gibberellic acid (GA3) concentrations, i.e., 0, 80, 160, and 240 mg/L, and the sub-sub plots received GA3 application twice, i.e., 60 and 120 days after planting (DAP). The results showed that both root length and diameter, root and foliage fresh weights/plant, and root and foliage yields/ha increased with the incremental level of nitrogen and/or GA3 concentration. Foliar application of GA3 and N-fertilizers also significantly decreased quality parameters including sucrose and total soluble solid (TSS) percentages. Early application of GA3 (60 DAP) had an active role on sugar beet growth, yield, and quality compared with spraying at 120 DAP. Generally, fertilizing sugar beet with 275 kg N/ha or spraying GA3 with a concentration of 160 mg/L at 60 DAP is the recommended treatment for raising sugar yield under the ecological circumstances of this research.
Determining Farmers’ Willingness to Pay for Irrigation Water in the Alentejo Region (Southern Portugal) by the Residual Value Method
Authors: Rodrigues Gonçalo C. , da Silva Francisco G. , Coelho José C.
Published: January 2021

This paper aims to determine farmers’ willingness to pay for irrigation water, using the residual value method, for the most representative crops at six Irrigation Communities from the Alentejo region, southern Portugal. The main objective of this assessment was to determine the value that farmers would be able to pay for the water to irrigate different crops at different locations, and to show that this approach can be used to provide information about farming economic sustainability and provide support on if crop prices need to be revised or if a national policy should be conceived to cover for farming costs. The results show that vegetables and fruit trees have the highest Residual Value of Water (RVW), while Wheat, Sunflower, Fodder crops, Semi-intensive Olive Orchards and Rice tend to have an RVW lower than the current variable irrigation water price. The results also show that, while, for Melon, Tomato, Onion, Super-high-density Olive Orchards, Peach and Almonds, both yields and price may decrease significantly, allowing one to save for faming inputs, Sunflower and Rice would require an increase in yields or prices to cover for the irrigation water price.
Experimental Analysis of Ultrasonic Multiple Scattering Attenuation through the Air with Fine Dust
Authors: Woo Ukyong , Choi Hajin , Song Homin
Published: January 2021

In this study, we experimentally evaluated the application of multiple scattering theory for measuring ultrasonic attenuation. Based on the independent approximation theory, the method adopted for calculating the attenuation of coherent waves through air with fine dust is discussed. To obtain a scattering wavefield, a unique ultrasonic scattering hardware was developed, and signal processing schemes were suggested. Four cases of standard particle doses (0, 0.004, 0.008, and 0.012 g) were investigated inside a chamber. The results obtained from the experiments demonstrate that the proposed signal processing approach successfully calculates the scattering attenuation, which correlates well with the applied doses of fine dust. In addition, we discuss the irregular shape and composition of fine dust relative to the scattering cross-section.
The Effect of Chairside Verbal Instructions Matched with Instagram Social Media on Oral Hygiene of Young Orthodontic Patients: A Randomized Clinical Trial
Authors: Scribante Andrea , Gallo Simone , Bertino Karin , Meles Stefania , Gandini Paola , Sfondrini Maria Francesca
Published: January 2021

Objective: To investigate the effectiveness of Instagram in improving oral hygiene compliance and knowledge in young orthodontic patients compared to traditional chairside verbal instructions. Design: Single-center, parallel, randomized controlled trial. Setting: Section of Dentistry of University of Pavia. Participants: 40 patients having fixed appliances in both arches were recruited and randomly divided into an intervention (n = 20) and a control group (n = 20). Intervention: At a first appointment, both groups were given verbal instructions and motivated to oral hygiene. In addition, multimedia contents on Instagram were sent weekly to trial participants for six months. Main outcome measures: For all participants, the bleeding index (BI), modified gingival index (MGI), and plaque index (PI) were assessed at baseline (T0), after one (T1), three (T2), and six months (T3). A questionnaire was administered at the beginning (T0) and at the end of the study (T3) to assess participants’ knowledge. Results: In both groups, BI, MGI, and PI significantly decreased (p < 0.05) at T1 (means control group: BI 0.26 ± 0.22, MGI 0.77 ± 0.36, PI 0.53 ± 0.20; means test group: BI 0.24 ± 0.22, MGI 0.65 ± 0.46, PI 0.49 ± 0.21) compared to baseline (means control group: BI 0.56 ± 0.27, MGI 1.23 ± 0.41, PI 0.87 ± 0.23; means test group: BI 0.54 ± 0.26, MGI 1.18 ± 0.39, PI 0.93 ± 0.20) but no significant differences in clinical measures were showed between T1, T2, and T3 (p > 0.05) (intragroup differences). Trial patients demonstrated significant improvements in knowledge with respect to controls comparing scores at T0 and T3 (p < 0.05) but despite this result in the test group clinical outcomes did not report significant intergroup differences at any time (p > 0.05). Conclusions: Presenting multimedia information through Instagram resulted in a significant improvement in knowledge. Therefore, this social media represents an aid to the standard verbal motivation performed by orthodontists towards young patients under an orthodontic treatment.
Three-Dimensional Mapping of Forest Soil Carbon Stocks Using SCORPAN Modelling and Relative Depth Gradients in the North-Eastern Lowlands of Germany
Authors: Russ Alexander , Riek Winfried , Wessolek Gerd
Published: January 2021

To cope with the challenges in forest management that are contemporarily caused by climate change, data on current chemical and physical soil properties are more and more necessary. For this purpose, we present a further amalgam of depth functions and SCORPAN modelling to provide data at arbitrary depth layers. In this concept, regionalisation is split up into the modelling of plot totals and the estimation of vertical distributions. The intended benefits by splitting up are: consistency between estimates on plot level and depth layer level, avoidance of artificial depth gradients, straightforward interpretation of covariates in the sense of pedogenetic processes, and circumnavigation of the propagation of uncertainties associated with separation between horizons during field sampling. The methodology was tailored to the circumstances within the north-eastern lowlands and the utilisation of current inventory data of the National Forest Soil Inventory (NFSI) in Brandenburg (Germany). Using the regionalisation of soil organic carbon (SOC) as an example, the application is demonstrated and discussed in detail. The depth to groundwater table and terrain parameters related to the catchment area were the main factors in SOC storage. The use of kriging did not improve the model performance. The relative depth gradients of SOC were especially distinguished by tree species composition and stand age. We suppose that interesting fields of application may be found in scenario-based modelling of SOC and when SOC serves as a basis for hydrological modelling.
User Clustering and Power Allocation for Energy Efficiency Maximization in Downlink Non-Orthogonal Multiple Access Systems
Authors: Chen Ruibiao , Shu Fangxing , Lei Kai , Wang Jianping , Zhang Liangjie
Published: January 2021

Non-orthogonal multiple access (NOMA) has been considered a promising technique for the fifth generation (5G) mobile communication networks because of its high spectrum efficiency. In NOMA, by using successive interference cancellation (SIC) techniques at the receivers, multiple users with different channel gain can be multiplexed together in the same subchannel for concurrent transmission in the same spectrum. The simultaneously multiple transmission achieves high system throughput in NOMA. However, it also leads to more energy consumption, limiting its application in many energy-constrained scenarios. As a result, the enhancement of energy efficiency becomes a critical issue in NOMA systems. This paper focuses on efficient user clustering strategy and power allocation design of downlink NOMA systems. The energy efficiency maximization of downlink NOMA systems is formulated as an NP-hard optimization problem under maximum transmission power, minimum data transmission rate requirement, and SIC requirement. For the approximate solution with much lower complexity, we first exploit a quick suboptimal clustering method to assign each user to a subchannel. Given the user clustering result, the optimal power allocation problem is solved in two steps. By employing the Lagrangian multiplier method with Karush–Kuhn–Tucker optimality conditions, the optimal power allocation is calculated for each subchannel. In addition, then, an inter-cluster dynamic programming model is further developed to achieve the overall maximum energy efficiency. The theoretical analysis and simulations show that the proposed schemes achieve a significant energy efficiency gain compared with existing methods.
Effect of Wetting Conditions on the In Situ Density of Soil Using the Sand-Cone Method
Authors: Park Sung-Sik , Ogunjinmi Peter D. , Lee Hyun-Il , Woo Seung-Wook , Lee Dong-Eun
Published: January 2021

The sand-cone method is commonly used to measure the in situ density of compacted soils. While determining field density with this method, differences in the sand-filling process between the test hole and the calibration container can cause errors. The differences can result from various in situ conditions such as the shape and size of the test hole and the moisture conditions of the filling sand and test ground. Temporary rainfall can increase the moisture content of both in situ soils and filling sand. This study examined the effect of wetting conditions on the accuracy of the sand-cone method in a laboratory. Compacted soils with different water contents (2–16%) were prepared in a small circular container in the laboratory, and the sand-filling process was simulated for cylindrical, conical, and roof-shaped test holes with depths of 10 and 15 cm. As the water content of the compacted soils increased, the sand-cone method underestimated the volume of sand accumulated in the test holes by up to 20%, resulting in the calculated density being overestimated by an identical amount. Slightly moist sand was poured into artificial test holes. When the water content of the filling sand was below 1%, no significant error was observed in the calculated volume.
A Study on the Improvement of Efficiency by Detection Solar Module Faults in Deteriorated Photovoltaic Power Plants
Authors: Hwang Myeong-Hwan , Kim Young-Gon , Lee Hae-Sol , Kim Young-Dae , Cha Hyun-Rok
Published: January 2021

In recent years, photovoltaic (PV) power generation has attracted considerable attention as a new eco-friendly and renewable energy generation technology. With the recent development of semiconductor manufacturing technologies, PV power generation is gradually increasing. In this paper, we analyze the types of defects that form in PV power generation panels and propose a method for enhancing the productivity and efficiency of PV power stations by determining the defects of aging PV modules based on their temperature, power output, and panel images. The method proposed in the paper allows the replacement of individual panels that are experiencing a malfunction, thereby reducing the output loss of solar power generation plants. The aim is to develop a method that enables users to immediately check the type of failures among the six failure types that frequently occur in aging PV panels—namely, hotspot, panel breakage, connector breakage, busbar breakage, panel cell overheating, and diode failure—based on thermal images by using the failure detection system. By comparing the data acquired in the study with the thermal images of a PV power station, efficiency is increased by detecting solar module faults in deteriorated photovoltaic power plants.
Data-Driven Wildfire Risk Prediction in Northern California
Authors: Malik Ashima , Rao Megha Rajam , Puppala Nandini , Koouri Prathusha , Thota Venkata Anil Kumar , Liu Qiao , Chiao Sen , Gao Jerry
Published: January 2021

Over the years, rampant wildfires have plagued the state of California, creating economic and environmental loss. In 2018, wildfires cost nearly 800 million dollars in economic loss and claimed more than 100 lives in California. Over 1.6 million acres of land has burned and caused large sums of environmental damage. Although, recently, researchers have introduced machine learning models and algorithms in predicting the wildfire risks, these results focused on special perspectives and were restricted to a limited number of data parameters. In this paper, we have proposed two data-driven machine learning approaches based on random forest models to predict the wildfire risk at areas near Monticello and Winters, California. This study demonstrated how the models were developed and applied with comprehensive data parameters such as powerlines, terrain, and vegetation in different perspectives that improved the spatial and temporal accuracy in predicting the risk of wildfire including fire ignition. The combined model uses the spatial and the temporal parameters as a single combined dataset to train and predict the fire risk, whereas the ensemble model was fed separate parameters that were later stacked to work as a single model. Our experiment shows that the combined model produced better results compared to the ensemble of random forest models on separate spatial data in terms of accuracy. The models were validated with Receiver Operating Characteristic (ROC) curves, learning curves, and evaluation metrics such as: accuracy, confusion matrices, and classification report. The study results showed and achieved cutting-edge accuracy of 92% in predicting the wildfire risks, including ignition by utilizing the regional spatial and temporal data along with standard data parameters in Northern California.
A Complete CDW Theory for the Single Ionization of Multielectronic Atoms by Bare Ion Impact
Authors: Monti Juan M. , Quinto Michele A. , Rivarola Roberto D.
Published: January 2021

A complete form of the post version of the continuum distorted wave (CDW) theory is used to investigate the single ionization of multielectronic atoms by fast bare heavy ion beams. The influence of the non-ionized electrons on the dynamic evolution is included through a residual target potential considered as a non-Coulomb central potential through a GSZ parametric one. Divergences found in the transition amplitude containing the short-range part of the target potential are avoided by considering, in that term exclusively, an eikonal phase instead of the continuum factor as the initial channel distortion function. In this way, we achieve the inclusion of the interaction between the target active electron and the residual target, giving place to a more complete theory. The present analysis is supported by comparisons with existing experimental electron emission spectra and other distorted wave theories.
Changes of Gut-Microbiota-Liver Axis in Hepatitis C Virus Infection
Authors: El-Mowafy Mohammed , Elgaml Abdelaziz , El-Mesery Mohamed , Sultan Salma , Ahmed Tamer A. E. , Gomaa Ahmed I. , Aly Mahmoud , Mottawea Walid
Published: January 2021

The gut–liver-axis is a bidirectional coordination between the gut, including microbial residents, the gut microbiota, from one side and the liver on the other side. Any disturbance in this crosstalk may lead to a disease status that impacts the functionality of both the gut and the liver. A major cause of liver disorders is hepatitis C virus (HCV) infection that has been illustrated to be associated with gut microbiota dysbiosis at different stages of the disease progression. This dysbiosis may start a cycle of inflammation and metabolic disturbance that impacts the gut and liver health and contributes to the disease progression. This review discusses the latest literature addressing this interplay between the gut microbiota and the liver in HCV infection from both directions. Additionally, we highlight the contribution of gut microbiota to the metabolism of antivirals used in HCV treatment regimens and the impact of these medications on the microbiota composition. This review sheds light on the potential of the gut microbiota manipulation as an alternative therapeutic approach to control the liver complications post HCV infection.
Lactobacillus rhamnosus AD3 as a Promising Alternative for Probiotic Products
Authors: Stivala Aldo , Carota Giuseppe , Fuochi Virginia , Furneri Pio Maria
Published: January 2021

Lactobacillus strains dominate the vaginal habitat and they are associated with a lower risk of genital infections. In addition, they contribute to the conservation of the vaginal microbiota by producing postbiotic agents. Previous studies have shown that their predominance involves antimicrobial activity against urogenital pathologies. In this context, probiotics may improve treatment outcomes. The aim of this study was to evaluate the probiotic properties of lactobacilli strains of vaginal origin using a multidisciplinary approach. For this purpose, safety criteria, ability to resist at low pH and bile salts, antimicrobial activity, ability to produce biofilm, capacity to produce hydrogen peroxide and more importantly, auto-aggregation, co-aggregation (with Candida spp.) and adhesion to human cells were evaluated. The strains belonged to the species of L. crispatus, L. gasseri, L. rhamnosus and L. delbruckii. Among these, a strain of L. rhamnosus named AD3 showed the best probiotic properties. As probiotics are already in use in many clinical practice and there are no major safety concerns, L. rhamnosus AD3 showed promise in becoming a prevention and complementary treatment option for urogenital diseases. Indeed, these results suggest that strain L. rhamnosus AD3 is non-pathogenic and likely to be safe for human consumption. This study revealed the great amensalistic properties of a new L. rhamnosus strain which can aim to be used as probiotic in pharmaceutical applications.
Assessing the Relationship between Verbal and Nonverbal Cognitive Abilities Using Resting-State EEG Functional Connectivity
Authors: Feklicheva Inna , Zakharov Ilya , Chipeeva Nadezda , Maslennikova Ekaterina , Korobova Svetlana , Adamovich Timofey , Ismatullina Victoria , Malykh Sergey
Published: January 2021

The present study investigates the relationship between individual differences in verbal and non-verbal cognitive abilities and resting-state EEG network characteristics. We used a network neuroscience approach to analyze both large-scale topological characteristics of the whole brain as well as local brain network characteristics. The characteristic path length, modularity, and cluster coefficient for different EEG frequency bands (alpha, high and low; beta1 and beta2, and theta) were calculated to estimate large-scale topological integration and segregation properties of the brain networks. Betweenness centrality, nodal clustering coefficient, and local connectivity strength were calculated as local network characteristics. We showed that global network integration measures in the alpha band were positively correlated with non-verbal intelligence, especially with the more difficult part of the test (Raven’s total scores and E series), and the ability to operate with verbal information (the “Conclusions” verbal subtest). At the same time, individual differences in non-verbal intelligence (Raven’s total score and C series), and vocabulary subtest of the verbal intelligence tests, were negatively correlated with the network segregation measures. Our results show that resting-state EEG functional connectivity can reveal the functional architecture associated with an individual difference in cognitive performance.
Internal Carotid Artery Injury in Transsphenoidal Surgery: Tenets for Its Avoidance and Refit—A Clinical Study
Authors: Usachev Dmitry , Sharipov Oleg , Abdali Ashraf , Yakovlev Sergei , Lukshin Vasiliy , Kutin Maksim , Fomichev Dmitry , Dorokhov Pavel , Bukharin Evgeny , Shkarubo Alexey , Chernov Ilya , Panteleyev Andrey , Yağmurlu Kaan , Chaurasia Bipin , Kalinin Pavel
Published: January 2021

One of the most serious/potentially fatal complications of transsphenoidal surgery (TSS) is internal carotid artery (ICA) injury. Of 6230 patients who underwent TSS, ICA injury occurred in 8 (0.12%). The etiology, possible treatment options, and avoidance of ICA injury were analyzed. ICA injury occurred at two different stages: (1) during the exposure of the sella floor and dural incision over the sella and cavernous sinus and (2) during the resection of the cavernous sinus extension of the tumor. The angiographic collateral blood supply was categorized as good, sufficient, and nonsufficient to help with the decision making for repairing the injury. ICA occlusion with a balloon was performed at the injury site in two cases, microcoils in two patients, microcoils plus a single barrel extra-intracranial high-flow bypass in one case, stent grafting in one case, and no intervention in two cases. The risk of ICA injury diminishes with better preoperative preparation, intraoperative navigation, and ultrasound dopplerography. Reconstructive surgery for closing the defect and restoring the blood flow to the artery should be assessed depending on the site of the injury and the anatomical features of the ICA.
“My Brain Can Stop”: An ERP Study of Longitudinal Prediction of Inhibitory Control in Adolescence
Authors: Einziger Tzlil , Ben-Shachar Mattan S. , Devor Tali , Shmueli Michael , Auerbach Judith G. , Berger Andrea
Published: January 2021

We examined the longitudinal predictors of electrophysiological and behavioral markers of inhibitory control in adolescence. Participants were 63 adolescent boys who have been followed since birth as part of a prospective longitudinal study on the developmental pathways to attention-deficit hyperactivity disorder (ADHD). At 17 years of age, they completed the stop-signal task (SST) while electroencephalography (EEG) was continuously recorded. Inhibitory control was evaluated by the stop-signal reaction time (SSRT) as well as by the amplitude of the event-related potential (ERP) component of N2 during successful inhibition. We found that higher inattention symptoms throughout childhood predicted reduced amplitude (i.e., less negative) of the N2 in adolescence. Furthermore, the N2 amplitude was longitudinally predicted by the early precursors of child familial risk for ADHD and early childhood temperament. Specifically, father’s inattention symptoms (measured in the child’s early infancy) and child’s effortful control at 36 months of age directly predicted the N2 amplitude in adolescence, even beyond the consistency of inattention symptoms throughout development. The SSRT was predicted by ADHD symptoms throughout childhood but not by the early precursors. Our findings emphasize the relevance of early familial and temperamental risk for ADHD to the prediction of a later dysfunction in inhibitory control.
C6 Ceramide (d18:1/6:0) as a Novel Treatment of Cutaneous T Cell Lymphoma
Authors: Wilhelm Raphael , Eckes Timon , Imre Gergely , Kippenberger Stefan , Meissner Markus , Thomas Dominique , Trautmann Sandra , Merlio Jean-Philippe , Chevret Edith , Kaufmann Roland , Pfeilschifter Josef , Koch Alexander , Jäger Manuel
Published: January 2021

Cutaneous T cell lymphomas (CTCLs) represent a heterogeneous group of T cell lymphomas that primarily affect the skin. The most frequent forms of CTCL are mycosis fungoides and Sézary syndrome. Both are characterized by frequent recurrence, developing chronic conditions and high mortality with a lack of a curative treatment. In this study, we evaluated the effect of short-chain, cell-permeable C6 Ceramide (C6Cer) on CTCL cell lines and keratinocytes. C6Cer significantly reduced cell viability of CTCL cell lines and induced cell death via apoptosis and necrosis. In contrast, primary human keratinocytes and HaCaT keratinocytes were less affected by C6Cer. Both keratinocyte cell lines showed higher expressions of ceramide catabolizing enzymes and HaCaT keratinocytes were able to metabolize C6Cer faster and more efficiently than CTCL cell lines, which might explain the observed protective effects. Along with other existing skin-directed therapies, C6Cer could be a novel well-tolerated drug for the topical treatment of CTCL.
Lysine Deprivation Induces AKT-AADAT Signaling and Overcomes EGFR-TKIs Resistance in EGFR-Mutant Non-Small Cell Lung Cancer Cells
Authors: Hsu Chia-Chi , Yang Albert Ying-Po , Chen Jui-Yi , Tsai Hsin-Hui , Lin Shu-Heng , Tai Pei-Chen , Huang Ming-Hung , Hsu Wei-Hsun , Lin Anya Maan-Yuh , Yang James Chih-Hsin
Published: January 2021

Epidermal growth factor receptor (EGFR) mutations are the most common driver genes in non-small cell lung cancer (NSCLC), especially in the Asian population. Although EGFR-tyrosine kinase inhibitors (TKIs) are influential in the treatment of EGFR-mutant NSCLC patients, acquired resistance inevitably occurs. Therefore, there is an urgent need to develop strategies to overcome this resistance. In addition, cancer cells with particular mutations appear more vulnerable to deficiency related to the availability of specific amino acids. However, it is still unknown which amino acid is affected in the case of EGFR-mutant NSCLC. In the present study, we established a screening platform based on amino acid deprivation and found that EGFR-mutant NSCLC cells are sensitive to short-term lysine deprivation. Moreover, we found that expression of the gene for the lysine catabolism enzyme α-aminoadipate aminotransferase (AADAT) increased under lysine deprivation, revealing that AADAT can be regulated by EGFR–AKT signaling. Finally, we found that lysine reduction can not only enhance the cytostatic effect of single-agent osimertinib but also overcome the resistance of EGFR-TKIs in EGFR-mutant NSCLC cells. In summary, our findings suggest that the introduction of lysine stress might act as an advancement in EGFR-mutant NSCLC therapy and offer a strategy to overcome EGFR-TKI resistance.