bluuebunny/crossref_metadata_2025 huggingface dataset:
Luminescent Amorphous Silicon Oxynitride Systems: High Quantum Efficiencies in the Visible Range
Authors: Zhang Pengzhan , Zhang Leng , Lyu Fei , Wang Danbei , Zhang Ling , Wu Kongpin , Wang Sake , Tang Chunmei
Published: April 2023

In recent years, researchers have placed great importance on the use of silicon (Si)-related materials as efficient light sources for the purpose of realizing Si-based monolithic optoelectronic integration. Previous works were mostly focused on Si nanostructured materials, and, so far, exciting results from Si-based compounds are still lacking. In this paper, we have systematically demonstrated the high photoluminescence external quantum efficiency (PL EQE) and internal quantum efficiency (PL IQE) of amorphous silicon oxynitride (a-SiNxOy) systems. Within an integration sphere, we directly measured the PL EQE values of a-SiNxOy, which ranged from approximately 2% to 10% in the visible range at room temperature. Then, we calculated the related PL IQE through temperature-dependent PL measurements. The obtained PL IQE values (~84% at 480 nm emission peak wavelength) were very high compared with those of reported Si-based luminescent thin films. We also calculated the temperature-dependent PL EQE values of a-SiNxOy systems, and discussed the related PL mechanisms.
Validity of Interviewer-Administered 24-h Dietary Recalls in Older Korean Women: A Pilot Study
Authors: Kim Seunghee , Park Clara Y.
Published: April 2023

Despite the wide use of 24-h dietary recalls and differences in food culture between Western and Asian countries, limited studies validating 24-h dietary recalls have been performed in rice-based meals and in Asians. To determine the accuracy of 24-h dietary recalls in Koreans, 22 older women participating in a controlled-feeding study completed a single interviewer-administered 24-h dietary recall. The recalls of food items were classified as matches, exclusions, or intrusions. Portion size reports were categorized as corresponding (≤10% error), overreport, underreport, and missing. Recall accuracy was analyzed according to the type of dish, food group, or nutrients and compared by one-way analysis of variance or paired t-test. Participants reported 95% of the foods that they consumed. Sauces were most frequently missing. Corresponding portion sizes were 24%, while 43% were underreported. Kimchi was most frequently underreported. No difference was found among food groups. The recalled intakes of energy and most nutrients were similar to the actual intakes, with the exception of fat and sodium, which were underreported. The interviewer-administered 24-h dietary recall may be a reliable tool to assess food and nutrient intake in older Korean women. More accurate methods are necessary to assess sauce, kimchi, fat, and sodium intakes in the Korean diet.
Nutritional Status, Refeeding Syndrome and Some Associated Factors of Patients at COVID-19 Hospital in Vietnam
Authors: Nguyen Linh Thuy , Ta Thanh Van , Bui An Tuong , Vo Sy Nam , Nguyen Ngoc-Lan Thi
Published: April 2023

Multisystem inflammatory syndrome is associated with COVID-19 and can result in reduced food intake, increased muscle catabolism, and electrolyte imbalance. Therefore COVID-19 patients are at high risk of being malnourished and of refeeding syndrome. The present study aimed to determine the prevalence and correlates of malnutrition and refeeding syndrome (RS) among COVID-19 patients in Hanoi, Vietnam. This prospective cohort study analyzed data from 1207 patients who were treated at the COVID-19 hospital of Hanoi Medical University (HMUH COVID-19) between September 2021 and March 2022. Nutritional status was evaluated by the Global Leadership Initiative on Malnutrition (GLIM) and laboratory markers. GLIM-defined malnutrition was found in 614 (50.9%) patients. Among those with malnutrition, 380 (31.5%) and 234 (19.4%) had moderate and severe malnutrition, respectively. The prevalence of risk of RS was 346 (28.7%). Those with severe and critical COVID symptoms are more likely to be at risk of RS compared to those with mild or moderate COVID, and having severe and critical COVID-19 infection increased the incidence of RS by 2.47 times, compared to mild and moderate disease. There was an association between levels of COVID-19, older ages, comorbidities, the inability of eating independently, hypoalbuminemia and hyponatremia with malnutrition. The proportion of COVID-19 patients who suffered from malnutrition was high. These results underscore the importance of early nutritional screening and assessment in COVID-19 patients, especially those with severe and critical infection.
The Importance of an Early Evaluation after Establishing a Gluten-Free Diet in Children with Celiac Disease
Authors: Martín-Masot Rafael , Jiménez-Muñoz María , Herrador-López Marta , Flor-Alemany Marta , Navas-López Víctor Manuel , Nestares Teresa
Published: April 2023

A gluten-free diet (GFD) is the only treatment available for celiac disease (CD); hence, it is important to ensure correct adherence to the diet and adequate monitoring of the diet. The present study aims to assess the importance of an early follow-up of celiac patients after diagnosis of the disease, identify the role of stool gluten immunogenic peptides (GIPs) in the assessment of GFD adherence, and analyze possible nutritional imbalances or deficiencies in the GFD. This is a cross-sectional study carried out in pediatric patients with newly diagnosed CD in a tertiary hospital in Spain. Of the 61 patients included, 14% had positive stool GIPS at 4 months after CD diagnosis, Among them, 88% had negative stool GIPS at 9 months after diagnosis, following dietary advice. We found nutritional deficiencies in the GFD, such as vitamin D (with only 27% of patients with adequate intakes), folate, calcium, magnesium, and fiber. Similarly, we found imbalances: excess protein and fat intakes and a high percentage of total daily energy intake came from ultra-processed foods (UPF). These findings emphasize the importance of early follow-up of children after diagnosis of CD. It is also crucial to identify patients with poor GFD compliance based on stool GIPS and analyze GFD nutritional imbalances and deficits. Our findings may contribute to the development of specific strategies for the early follow-up of patients with CD, including appropriate nutritional counselling.
Can Circadian Eating Pattern Adjustments Reduce Risk or Prevent Development of T2D?
Authors: Harris Carlee , Czaja Krzysztof
Published: April 2023

Type 2 diabetes (T2D) is a chronic condition that occurs in insulin-resistant people with reduced glucose uptake. It is contributed to and exacerbated by a poor diet that results in accumulation of adipose tissue, high blood sugar, and other metabolic issues. Because humans have undergone food scarcity throughout history, our species has adapted a fat reserve genotype. This adaptation is no longer beneficial, as eating at a higher frequency than that of our ancestors has had a significant effect on T2D development. Eating at high frequencies disrupts the circadian clock, the circadian rhythm, and the composition of the gut microbiome, as well as hormone secretion and sensitivity. The current literature suggests an improved diet requires meal consistency, avoiding late-night eating, low meal frequency, and fasting to increase metabolic health. In addition, fasting as a treatment for T2D must be used correctly for beneficial results. Early time-restricted eating (TRE) provides many benefits such as improving insulin resistance, cognitive function, and glycemic control. Alternate-day fasting (ADF), 5:2 fasting, and long-term fasting all have benefits; however, they may be less advantageous than early TRE. Therefore, eating pattern adjustments can be used to reduce T2D if used correctly.
Recombinant Human Interleukin-2 Corrects NK Cell Phenotype and Functional Activity in Patients with Post-COVID Syndrome
Authors: Savchenko Andrei A. , Kudryavtsev Igor V. , Isakov Dmitry V. , Sadowski Ivan S. , Belenyuk Vasily D. , Borisov Alexandr G.
Published: April 2023

Post-COVID syndrome develops in 10–20% of people who have recovered from COVID-19 and it is characterized by impaired function of the nervous, cardiovascular, and immune systems. Previously, it was found that patients who recovered from infection with the SARS-CoV-2 virus had a decrease in the number and functional activity of NK cells. The aim of the study was to assess the effectiveness of recombinant human IL-2 (rhIL-2) administered to correct NK cell phenotype and functional activity in patients with post-COVID syndrome. Patients were examined after 3 months for acute COVID-19 of varying severity. The phenotype of the peripheral blood NK cells was studied by flow cytometry. It was found that disturbances in the cell subset composition in patients with post-COVID syndrome were characterized by low levels of mature (p = 0.001) and cytotoxic NK cells (p = 0.013), with increased release of immature NK cells (p = 0.023). Functional deficiency of NK cells in post-COVID syndrome was characterized by lowered cytotoxic activity due to the decreased count of CD57+ (p = 0.001) and CD8+ (p < 0.001) NK cells. In the treatment of patients with post-COVID syndrome with recombinant IL-2, peripheral blood NK cell count and functional potential were restored. In general, the effectiveness of using rhIL-2 in treatment of post-COVID syndrome has been proven in patients with low levels of NK cells.
Development of a Peptide-Based Nano-Sized Cathepsin B Inhibitor for Anticancer Therapy
Authors: Park So-Hyeon , Lee Jun-Hyuck , Yang Seong-Bin , Lee Dong-Nyeong , Kang Tae-Bong , Park Jooho
Published: April 2023

Numerous cathepsin B inhibitors have been developed and are under investigation as potential cancer treatments. They have been evaluated for their ability to inhibit cathepsin B activity and reduce tumor growth. However, they have shown critical limitations, including low anticancer efficacy and high toxicity, due to their low selectivity and delivery problems. In this study, we developed a novel peptide and drug conjugate (PDC)-based cathepsin B inhibitor using cathepsin-B-specific peptide (RR) and bile acid (BA). Interestingly, this RR and BA conjugate (RR–BA) was able to self-assemble in an aqueous solution, and as a result, it formed stable nanoparticles. The nano-sized RR–BA conjugate showed significant cathepsin B inhibitory effects and anticancer effects against mouse colorectal cancer (CT26) cells. Its therapeutic effect and low toxicity were also confirmed in CT26 tumor-bearing mice after intravenous injection. Therefore, based on these results, the RR–BA conjugate could be developed as an effective anticancer drug candidate for inhibiting cathepsin B in anticancer therapy.
Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes
Authors: Chang Hsuan-Ping , Le Huyen Khanh , Shah Dhaval K.
Published: April 2023

We hypothesize that different routes of administration may lead to altered pharmacokinetics/pharmacodynamics (PK/PD) behavior of antibody-drug conjugates (ADCs) and may help to improve their therapeutic index. To evaluate this hypothesis, here we performed PK/PD evaluation for an ADC administered via subcutaneous (SC) and intratumoral (IT) routes. Trastuzumab-vc-MMAE was used as the model ADC, and NCI-N87 tumor-bearing xenografts were used as the animal model. The PK of multiple ADC analytes in plasma and tumors, and the in vivo efficacy of ADC, after IV, SC, and IT administration were evaluated. A semi-mechanistic PK/PD model was developed to characterize all the PK/PD data simultaneously. In addition, local toxicity of SC-administered ADC was investigated in immunocompetent and immunodeficient mice. Intratumoral administration was found to significantly increase tumor exposure and anti-tumor activity of ADC. The PK/PD model suggested that the IT route may provide the same efficacy as the IV route at an increased dosing interval and reduced dose level. SC administration of ADC led to local toxicity and reduced efficacy, suggesting difficulty in switching from IV to SC route for some ADCs. As such, this manuscript provides unprecedented insight into the PK/PD behavior of ADCs after IT and SC administration and paves the way for clinical evaluation of these routes.
New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery
Authors: Chen Haishu , Xu Jinan , Xu Hanyuan , Luo Tiancheng , Li Yihao , Jiang Ke , Shentu Yangping , Tong Zhiqian
Published: April 2023

Alzheimer’s disease (AD), the most common type of dementia, is characterized by senile plaques composed of amyloid β protein (Aβ) and neurofilament tangles derived from the hyperphosphorylation of tau protein. However, the developed medicines targeting Aβ and tau have not obtained ideal clinical efficacy, which raises a challenge to the hypothesis that AD is Aβ cascade-induced. A critical problem of AD pathogenesis is which endogenous factor induces Aβ aggregation and tau phosphorylation. Recently, age-associated endogenous formaldehyde has been suggested to be a direct trigger for Aβ- and tau-related pathology. Another key issue is whether or not AD drugs are successfully delivered to the damaged neurons. Both the blood–brain barrier (BBB) and extracellular space (ECS) are the barriers for drug delivery. Unexpectedly, Aβ-related SP deposition in ECS slows down or stops interstitial fluid drainage in AD, which is the direct reason for drug delivery failure. Here, we propose a new pathogenesis and perspectives on the direction of AD drug development and drug delivery: (1) aging-related formaldehyde is a direct trigger for Aβ assembly and tau hyperphosphorylation, and the new target for AD therapy is formaldehyde; (2) nano-packaging and physical therapy may be the promising strategy for increasing BBB permeability and accelerating interstitial fluid drainage.
Kinin B2 and B1 Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms
Authors: Fialho Maria Fernanda Pessano , Brum Evelyne Silva , Becker Gabriela , Brusco Indiara , Oliveira Sara Marchesan
Published: April 2023

Aromatase inhibitors (AIs) cause symptoms of musculoskeletal pain, and some mechanisms have been proposed to explain them. However, signaling pathways downstream from kinin B2 (B2R) and B1 (B1R) receptor activation and their possible sensitizing of the Transient Receptor Potential Ankyrin 1 (TRPA1) remain unknown. The interaction between the kinin receptor and the TRPA1 channel in male C57BL/6 mice treated with anastrozole (an AI) was evaluated. PLC/PKC and PKA inhibitors were used to evaluate the signaling pathways downstream from B2R and B1R activation and their effect on TRPA1 sensitization. Anastrozole caused mechanical allodynia and muscle strength loss in mice. B2R (Bradykinin), B1R (DABk), or TRPA1 (AITC) agonists induced overt nociceptive behavior and enhanced and prolonged the painful parameters in anastrozole-treated mice. All painful symptoms were reduced by B2R (Icatibant), B1R (DALBk), or TRPA1 (A967079) antagonists. We observed the interaction between B2R, B1R, and the TRPA1 channel in anastrozole-induced musculoskeletal pain, which was dependent on the activation of the PLC/PKC and PKA signaling pathways. TRPA1 seems to be sensitized by mechanisms dependent on the activation of PLC/PKC, and PKA due to kinin receptors stimulation in anastrozole-treated animals. Thus, regulating this signaling pathway could contribute to alleviating AIs-related pain symptoms, patients’ adherence to therapy, and disease control.
Nanothin Conformal Coating with Poly(N-vinylpyrrolidone) and Tannic Acid (PVPON/TA) Preserves Murine and Human Pancreatic Islets Function
Authors: Polishevska Kateryna , Kelly Sandra , Kuppan Purushothaman , Seeberger Karen L. , Aggarwal Saloni , Paramor Joy , Unsworth Larry D. , Tse Hubert M. , Korbutt Gregory S. , Pepper Andrew R.
Published: April 2023

Beta cell replacement therapies can restore glycemic control to select individuals living with type 1 diabetes. However, the obligation of lifelong immunosuppression restricts cell therapies from replacing exogenous insulin administration. Encapsulation strategies can reduce the inherent adaptive immune response; however, few are successfully translated into clinical testing. Herein, we evaluated if the conformal coating of islets with poly(N-vinylpyrrolidone) (PVPON) and tannic acid (TA) (PVPON/TA) could preserve murine and human islet function while conferring islet allograft protection. In vitro function was evaluated using static glucose-stimulated insulin secretion, oxygen consumption rates, and islet membrane integrity. In vivo function was evaluated by transplanting human islets into diabetic immunodeficient B6.129S7-Rag1tm1Mom/J (Rag-/-) mice. The immunoprotective capacity of the PVPON/TA-coating was assessed by transplanting BALB/c islets into diabetic C57BL/6 mice. Graft function was evaluated by non-fasting blood glucose measurements and glucose tolerance testing. Both coated and non-coated murine and human islets exhibited indistinguishable in vitro potency. PVPON/TA-coated and control human islets were able to restore euglycemia post-transplant. The PVPON/TA-coating as monotherapy and adjuvant to systemic immunosuppression reduced intragraft inflammation and delayed murine allograft rejection. This study demonstrates that PVPON/TA-coated islets may be clinically relevant as they retain their in vitro and in vivo function while modulating post-transplant immune responses.
Intra-Arterial Delivery of Radiopharmaceuticals in Oncology: Current Trends and the Future of Alpha-Particle Therapeutics
Authors: Kauffman Nathan , Morrison James , O’Brien Kevin , Fan Jinda , Zinn Kurt R.
Published: April 2023

A paradigm shift is underway in cancer diagnosis and therapy using radioactivity-based agents called radiopharmaceuticals. In the new strategy, diagnostic imaging measures the tumor uptake of radioactive agent “X” in a patient’s specific cancer, and if uptake metrics are realized, the patient can be selected for therapy with radioactive agent “Y”. The X and Y represent different radioisotopes that are optimized for each application. X–Y pairs are known as radiotheranostics, with the currently approved route of therapy being intravenous administration. The field is now evaluating the potential of intra-arterial dosing of radiotheranostics. In this manner, a higher initial concentration can be achieved at the cancer site, which could potentially enhance tumor-to-background targeting and lead to improved imaging and therapy. Numerous clinical trials are underway to evaluate these new therapeutic approaches that can be performed via interventional radiology. Of further interest is changing the therapeutic radioisotope that provides radiation therapy by β- emission to radioisotopes that also decay by α-particle emissions. Alpha (α)-particle emissions provide high energy transfer to the tumors and have distinct advantages. This review discusses the current landscape of intra-arterially delivered radiopharmaceuticals and the future of α-particle therapy with short-lived radioisotopes.
Image Contrast Enhancement by Using LED Annular Oblique Illumination in Bright-Field Microscopy
Authors: Ma Xiao , Qi Pan , Wu Zhifeng , Yang Ying , Li Chengsen , Zhong Jingang
Published: April 2023

Köhler illumination is the most used method for evenly illuminating a sample in bright-field microscopy. However, Köhler illumination cannot provide optimum contrast and high resolution simultaneously. The image contrast for Köhler illumination can be enhanced at the expense of lateral resolution. In this paper, we discuss the main causes of contrast loss with Köhler illumination by simulating unsymmetrical interference, incoherent superposition, and modulation transfer function. We present a method to increase the image contrast by combining the annular oblique illumination with normalization and blind deconvolution. With the progress of optoelectronic devices, the greater advantages of annular oblique illumination will become apparent. The experimental results achieved by using LED annular oblique illumination prove the feasibility of the proposed method.
Multiscale Analysis of the Highly Stretchable Carbon−Based Polymer Strain Sensor
Authors: Wang Junpu , Wang Zhu , Zuo Yanjiang , Wang Wenzhi
Published: April 2023

In this paper, a multiscale analysis method was proposed to simulate carbon nanoparticles (CNPs)−filled polymers which can be strain sensors applied in wearable electronic devices, flexible skin, and health monitoring fields. On the basis of the microstructure characteristics of the composite, a microscale representative volume element model of the CNPs−filled polymer was established using the improved nearest−neighbor algorithm. By finite element analysis, the variation of the junction widths of adjacent aggregates can be extracted from the simulation results. Then, according to the conductive mechanism of CNP−filled polymers, the composite was simplified as a circuit network composed of vast random resistors which were determined by the junction widths between adjacent aggregates. Hence, by taking junction widths as the link, the resistance variation of the CNPs−filled polymer with the strain can be obtained. To verify the proposed method, the electromechanical responses of silicone elastomer filled with different CNPs under different filling amounts were investigated numerically and experimentally, respectively, and the results were in good agreement. Therefore, the multiscale analysis method can not only reveal the strain−sensing mechanism of the composite from the microscale, but also effectively predict the electromechanical behavior of the CNPs−filled polymer with different material parameters.
Covalent Triazine Frameworks Decorated with Pyridine-Type Carbonitride Moieties: Enhanced Photocatalytic Hydrogen Evolution by Improved Charge Separation
Authors: Kong Xianxian , Yang Fan , Li Xiaoying , Fu Mengying , Zeng Tao , Song Shuang , He Zhiqiao , Yu Yan
Published: April 2023

A simple procedure of calcination under an Ar atmosphere has been successfully applied to create a covalent triazine framework bearing pyridine-type carbonitride moieties (PCN@CTF). The appending of PCN on the CTF led to visible light absorption at up to 600 nm in the UV/Vis diffuse-reflectance spectra. Photoluminescence and electrochemical impedance spectroscopy have been applied to clarify how modification of the CTF with PCN enhanced the separation efficiency of photoexcited charge carriers. An optimized 1%PCN@CTF sample showed the highest photocatalytic hydrogen evolution reaction (HER) rate of 170.2 ± 2.3 μmol g−1·h−1, 3.9 times faster than that over the pristine CTF. The apparent quantum efficiency of the HER peaked at (7.57 ± 0.10)% at 490 nm. This representative 1% PCN@CTF sample maintained continuous function for at least 15 h. This work provides new guidance for modification with PCN materials as a means of obtaining high photocatalytic efficiency and sheds light on the effect of appended pyridine rings on a CTF.
Bio-Based Polyurethane Foams for the Removal of Petroleum-Derived Pollutants: Sorption in Batch and in Continuous-Flow
Authors: Olivito Fabrizio , Algieri Vincenzo , Jiritano Antonio , Tallarida Matteo Antonio , Costanzo Paola , Maiuolo Loredana , De Nino Antonio
Published: April 2023

In this paper, we evaluated the potential of two synthesized bio-based polyurethane foams, PU1 and PU2, for the removal of diesel and gasoline from water mixtures. We started the investigation with the experiment in batch. The total sorption capacity S (g/g) for the diesel/water system was slightly higher with respect to gasoline/water, with a value of 62 g/g for PU1 and 65 g/g for PU2. We found that the sorption follows a pseudo second-order kinetic model for both the materials. The experimental data showed that the best isotherm models were obtained with Langmuir and Redlich–Peterson models. In addition, to provide an idea of the process scalability for future industrial applications, we tested the sorption capacity of the foams using a continuous-flow of the same oil/water mixtures and we obtained performances even better with respect to the batch test. The regeneration can be performed up to 50 times by centrifuge, without losing efficacy.
In Vitro Effects of Waterborne Polyurethane 3D Scaffolds Containing Poly(lactic-co-glycolic acid)s of Different Lactic Acid/Glycolic Acid Ratios on the Inflammatory Response
Authors: Zhang Guanyu , Zhen Ao , Chen Jinlin , Du Bohong , Luo Feng , Li Jiehua , Tan Hong
Published: April 2023

The physical and chemical properties of tissue engineering scaffolds have considerable effects on the inflammatory response at the implant site in soft tissue repair. The development of inflammation-modulating polymer scaffolds for soft tissue repair is attracting increasing attention. In this study, in order to regulate the inflammatory response at the implant site, a series of waterborne polyurethane (WPU) scaffolds with different properties were synthesized using polyethylene glycol (PEG), polycaprolactone (PCL) and poly (lactic acid)–glycolic acid copolymers (PLGAs) with three lactic acid/glycolic acid (LA/GA) ratios as the soft segments. Then, scaffolds were obtained using freeze-drying. The WPU scaffolds exhibited a porous cellular structure, high porosity, proper mechanical properties for repairing nerve tissue and an adjustable degradation rate. In vitro cellular experiments showed that the degradation solution possessed high biocompatibility. The in vitro inflammatory response of C57BL/6 mouse brain microglia (immortalized) (BV2) cells demonstrated that the LA/GA ratio of the PLGA in WPU scaffolds can regulate the external inflammatory response by altering the secretion of IL-10 and TNF-α. Even the IL-10/TNF-α of PU5050 (3.64) reached 69 times that of the control group (0.053). The results of the PC12 culture on the scaffolds showed that the scaffolds had positive effects on the growth, proliferation and differentiation of nerve cells and could even promote the formation of synapses. Overall, these scaffolds, particularly the PU5050, indeed prevent BV2 cells from differentiating into a pro-inflammatory M1 phenotype, which makes them promising candidates for reducing the inflammatory response and repairing nerve tissue. Furthermore, PU5050 had the best effect on preventing the transformation of BV2 cells into the pro-inflammatory M1 phenotype.
Instant Controlled Pressure Drop (DIC) Processing to Reduce 3-Monochloropropane-1,2-diol Concentration in Palm Oil
Authors: Alzahrani Saleh A. , Jamoussi Bassem , Neamatallah Abdullatif A. , Aloufi Fahed A. , Halawani Riyadh F. , Chakroun Radhouane , Jablaoui Cherif
Published: April 2023

Deodorization of vegetable oils may introduce potentially carcinogenic, as well as genotoxic contaminants, generating health risks for consumers. However, the deodorization step of the refining process leads to the formation of 3-monochloro-1,2-propanediol (3-MCPD). 3-MCPD has been classified as potentially carcinogenic to humans by the World Health Organization (WHO). The purpose of this study was to optimize recently updated oil treatment techniques using Instant Controlled Pressure Drop (DIC) to improve 3-MCPD elimination in edible palm oil. Based on the central composite (CCD-DoE), response surface methodology (RSM) was developed to find the best combination of two variables at five levels to remove 3-MCPD from the palm oil. Samples of palm oil were split into two groups. The first group was treated only by the traditional method, including refining, degumming, deacidification, decolorization, deodorization, dehydration, filtration, and dewaxing processes. The second group was first treated by the traditional method, followed by the DIC technique during different periods at various temperatures and pressures. In the experiment, the effect of 3-MCPD removal in palm oil was examined by varying the oil inlet pressure and reaction time from 200 to 325 kPa and from 8.66 to 26.34 s/cycle, respectively. The 3D surface graphs showed that the optimum reduction of 3-MCPD occurs with a reaction time of 26.34s and a pressure value of 413 kPa. Samples of palm oil were analyzed using a GC-MS/MS method to determine 3-MCPD concentrations. It was found that the DIC technology reduces oil contamination with 3-MCPD when used after the traditional oil treatment process.
Stability Analysis Method for Initial Support Structure of Tunnel in Swelling Loess
Authors: Wu Jianxun , Jiang Jian , Li Zhanlin , Yang Yonghao , Hou Zhenkun , Sun Zhongxing , Gong Xing
Published: April 2023

The stability of tunnel is greatly affected by the changes in volume and strength of swelling loess caused by humidification. Quantitative reflection of the influence of humidification on stability in mechanical model has important engineering significance for the design of support structures. Based on the fact that parameters related to swelling and strength are functions of water content, the water content was introduced into the classical surrounding rock–support model, and a safety factor was employed as the index of stability. Thus, a stability analysis framework of swelling loess tunnel was established by considering the swelling and softening of swelling loess. In an engineering case, the theoretical models presented in this paper were introduced to investigate the change rules of surrounding rock deformation and tunnel safety factor, as well as the sensitivity of the safety factor of tunneling in swelling loess. Analysis results showed that the change rules of surrounding rock response curves and safety factors obtained by the models were consistent with the actual situation, and the predicted maximum radial displacement of free face was close to the measured value. These indicate that the models are applicable to the stability analysis of initial support of swelling loess tunnel.
The Influences of Emulsification Variables on Emulsion Characteristics Prepared through the Phase Inversion Temperature Method as Engine Fuel
Authors: Lin Cherng-Yuan , Lin Keng-Hung , Yang Hsuan
Published: April 2023

The effects of emulsification variables, such as surfactant type and heating/cooling emulsion processes, on the emulsification characteristics of silicone oil’s emulsions prepared by the phase inversion temperature method were investigated in this study. The water-in-oil (W/O) emulsions have been widely applied to enhance burning efficiency and reduce both pollutant emissions and fuel consumption. The silicone oil was emulsified with de-ionized water with the assistance of nonionic surfactants to form oil-in-water (O/W) emulsions. The hydrophilic–lipophilic balance (HLB) value of the Span 80 and Tween 20 surfactant mixture was set equal to 10 based on their weight proportions and the respective HLB values of the two surfactants. The experimental results show that the emulsions with the Span 80/Tween 20 surfactant mixture appeared to have a higher phase inversion temperature and a larger electrical conductance. On the other hand, it has a lower emulsification stability and a narrower range of phase inversion temperature than the emulsions prepared with a Brij 30 surfactant (polyoxyethylene (4) lauryl ether). The increase in surfactant concentration from 1 wt.% to 10 wt.% decreased the electrical conductance and phase inversion temperature while increasing the suspensibility and absorbance value for the emulsions prepared with either Span 80/Tween 20 mixture or Brij 30.
Changes in the Saliva Proteome of Pigs with Diarrhoea Caused by Escherichia coli
Authors: Rodrigues Miguel , López-Martinez Maria José , Ortin-Bustillo Alba , Cerón Jose Joaquin , Martinez-Subiela Silvia , Muñoz-Prieto Alberto , Lamy Elsa
Published: April 2023

Escherichia coli represents the main cause of diarrhoea in pigs. Saliva can provide information about the pathophysiology of diseases and be a source of biomarkers. We aimed to identify changes in the salivary proteome of pigs with diarrhoea caused by E. coli. Saliva samples were collected from 10 pigs with this disease and 10 matched healthy controls. SDS-PAGE (1DE) and two-dimensional gel electrophoresis (2DE) were performed, and significantly different protein bands and spots were identified by mass spectrometry. For validation, adenosine deaminase (ADA) was measured in 28 healthy and 28 diseased pigs. In 1DE, increases in lipocalin and IgA bands were observed for diseased pigs, whereas bands containing proteins such as odorant-binding protein and/or prolactin-inducible protein presented decreased concentrations. Two-dimensional gel electrophoresis (2DE) results showed that saliva from E. coli animals presented higher expression levels of lipocalin, ADA, IgA and albumin peptides, being ADA activity increased in the diseased pigs in the validation study. Spots containing alpha-amylase, carbonic anhydrase VI, and whole albumin were decreased in diseased animals. Overall, pigs with diarrhoea caused by E. coli have changes in proteins in their saliva related to various pathophysiological mechanisms such as inflammation and immune function and could potentially be biomarkers of this disease.
Assessing Systematic Blade Production in the Indian Subcontinent with Special Reference to Eastern Gujarat
Authors: Jha Gopesh , Kothari Vidhi , Vyas Varun , Ajithprasad P.
Published: April 2023

Blades as a component of lithic assemblages hold significant importance to understanding the more recent part of human evolution, particularly with regard to the emergence and adaptations of Homo sapiens. The systematic production of elongated stone blanks provides several advantages, including a longer cutting edge and high efficiency in raw material utility. However, the reasons behind the development of these technological forms and the chronological patterns of systematic blade production remain poorly understood in many regions, despite a clear overall intensification in the Late Pleistocene. The South Asian Paleolithic archive is full of blade-bearing assemblages, most of which are defined as Upper Paleolithic or Late Paleolithic. However, many of these previously assumed ‘Upper Paleolithic’ tool components prominently appear in Middle Paleolithic contexts. Here, we discuss some of the most recent case studies of blade-bearing assemblages from Eastern Gujarat that show an in situ emergence of blade technology from advanced Middle Paleolithic technology, suggesting localized origins of blade technology.
Four Chinese Buddhist Nuns’ Gender Anxiety in Their Colophons to the Da banniepan jing 大般涅槃經
Authors: Chen Ruifeng
Published: April 2023

Many scholars of Buddhism believe that Buddhists (particularly Mahāyāna Buddhists) regularly reproduce scriptures for merit in general, regardless of their content. However, by examining four Chinese Buddhist nuns’ colophons in manuscripts of the Da banniepan jing 大般涅槃經 (Scripture on the Great Extinction; Skt. Mahāparinirvāṇa-sūtra) (T no. 374) from around the sixth century with reference to its content, I argue that this scripture is significantly related to gender transformation and “female filth”. In this way, I suggest that these nuns could have deliberately commissioned this particular scripture due to their gender-based concerns. This study deepens our understanding of the reception of this scripture by Chinese Buddhist nuns by concentrating on the notion of gender, and it indicates that some nuns did not commission scriptures simply for merit without awareness of the scriptures’ content. This method of reading Buddhist texts as objects put into practice provides insight into the intellectual background of medieval Chinese Buddhist nuns, showing how they drew on their knowledge of Buddhist texts and financial resources to commission a specific scripture in order to negotiate more spiritual space.
“Because of Your Beard I Can Talk to You”: Rabbi Froman as Crisis Mediator between Israelis and Palestinians
Authors: Rubinstein-Shemer Nesya
Published: April 2023

The subject of this essay is the role Rabbi Menachem Froman played as a mediator in crises between Israelis and Palestinians against the background of his interreligious vision of peace and attempts to implement it. Rabbi Froman was very active in this matter and initiated various schemes to promote reconciliation between the Israelis and Palestinians, both in his discussions with religious leaders of the two peoples as well as with politicians in Israel and around the world. The network of contacts and the open discourse that the rabbi developed in order to promote his vision enabled him to serve as a mediator during numerous crises that arose in the Middle East, in general, and Israel in particular. This essay sheds light on Rabbi Froman’s attempts at mediation throughout the years, including the outline of a solution to the Israeli–Palestinian conflict he crafted with the other side. This essay is primarily based on archival materials and newspaper articles about the rabbi that were revealed after his death in 2013. The essay also chronologizes Rabbi Froman’s attempts to serve as mediator for the Israeli and Palestinian leadership and the “jihad for peace” he advocated.
A 3D Interferometer-Type Lightning Mapping Array for Observation of Winter Lightning in Japan
Authors: Yang Junchen , Wang Daohong , Huang Haitao , Wu Ting , Takagi Nobuyuki , Yamamoto Kazuo
Published: April 2023

We have developed and deployed a 3D Interferometer-type Lightning Mapping Array (InLMA) for observing winter lightning in Japan. InLMA consists of three broadband interferometers installed at three stations with a distance from 3 to 5 km. At each interferometer station, three discone antennas were installed, forming a right triangle with a separation of 75 m along their two orthogonal baselines. The output of each InLMA antenna is passed through a 400 MHz low-pass filter and then recorded at 1 GS/s with 16-bit accuracy. A new method has been proposed for finding 3D solutions of a lightning mapping system that consists of multiple interferometers. Using the InLMA, we have succeeded in mapping a positive cloud-to-ground (CG) lightning flash in winter, particularly its preliminary breakdown (PB) process. A study on individual PB pulse processes allows us to infer that each PB pulse process contains many small-scale discharges scattering in a height range of about 150 m. These small-scale discharges in a series of PB pulses appear to be continuous in space, though discontinuous in time. We have also examined the positive return stroke in the CG flash and found a 3D average return stroke speed of 7.5 × 107 m/s.
Comparing the Capability of Sentinel-2 and Landsat 9 Imagery for Mapping Water and Sandbars in the River Bed of the Lower Tagus River (Portugal)
Authors: Gerardo Romeu , de Lima Isabel P.
Published: April 2023

Mapping river beds to identify water and sandbars is a crucial task for understanding the morphology and hydrodynamics of rivers and their ecological conditions. The main difficulties of this task so far have been the limitations of conventional approaches, which are generally costly (e.g., equipment, time- and human resource-demanding) and have poor flexibility to deal with all river conditions. Currently, alternative approaches rely on remote sensing techniques, which offer innovative tools for mapping water bodies in a quick and cost-effective manner based on relevant spectral indices. This study aimed to compare the capability of using imagery from the Sentinel-2 and newly launched Landsat 9 satellite to achieve this goal. For a segment of the Lower Tagus River (Portugal) with conditions of very low river discharge, comparison of the Normalized Difference Water Index, Modified Normalized Difference Water Index, Augmented Normalized Difference Water Index, and Automated Water Extraction Index calculated from the imagery of the two satellites shows that the two satellites’ datasets and mapping were consistent and therefore could be used complementarily. However, the results highlighted the need to classify satellite imagery based on index-specific classification decision values, which is an important factor in the quality of the information extracted.
Spatio-Temporal Changes of Mangrove-Covered Tidal Flats over 35 Years Using Satellite Remote Sensing Imageries: A Case Study of Beibu Gulf, China
Authors: Gao Ertao , Zhou Guoqing
Published: April 2023

Tidal flats provide ecosystem services to billions of people worldwide; however, their changing status is largely unknown. Several challenges in the fine extraction of tidal flats using remote sensing techniques, including tide-level and water-edge line changes, exist at present, especially regarding the spatial and temporal distribution of mangroves. This study proposed a tidal flats extraction method using a combination of threshold segmentation and tidal-level correction, considering the influence of mangrove changes. We extracted the spatial distribution of tidal flats in Beibu Gulf, Southwest China, from 1987 to 2021 using time-series Landsat and Sentinel-2 images, and further analyzed the dynamic variation characteristics of the total tidal flats, each coastal segment, and the range of erosion and silting. To quantitatively investigate the interaction between tidal flats and mangroves, this study established a regression model based on multi-temporal tidal flats and mangrove data. The results indicated that the overall accuracy of the tidal flat extraction results was 93.9%, and the kappa coefficient was 0.82. The total area of tidal flats in Beibu Gulf decreased by 130 km2 from 1987 to 2021, with an average annual change of −3.7 km2/a. In addition, a negative correlation between the tidal flat change area and mangrove change area in Shankou, Maowei Sea, and Pearl Bay was observed, with correlation coefficients of −0.28, −0.30 and −0.64, respectively. These results demonstrate that the distribution of tidal flats provides a good environment and expansion space for the rapid growth of mangroves. These results can provide references for tidal flats’ resource conservation, ecological health assessment, and vegetation changes in coastal wetlands in China and other countries in Southeast Asia.
A New Algorithm for Ill-Posed Problem of GNSS-Based Ionospheric Tomography
Authors: Wen Debao , Xie Kangyou , Tang Yinghao , Mei Dengkui , Chen Xi , Chen Hanqing
Published: April 2023

Ill-posedness of GNSS-based ionospheric tomography affects the stability and the accuracy of the inversion results. Truncated singular value decomposition (TSVD) is a common algorithm of ionospheric tomography reconstruction. However, the TSVD method usually has low inversion accuracy and reconstruction efficiency. To resolve the above problem, a truncated mapping singular value decomposition (TMSVD) algorithm is presented to improve the reconstructed accuracy and computational efficiency. To authenticate the effectiveness and the advantages of the TMSVD algorithm, a numerical test scheme is devised. Finally, ionospheric temporal–spatial variations of the selected reconstructed region are studied using the GNSS observations under different geomagnetic conditions. The reconstructed results of TMSVD can accurately reflect semiannual anomalies, diurnal variations, and geomagnetic storm effects. In contrast with the ionosonde data, it is found that the reconstructed profiles of the TMSVD method are more consistent with than those of the IRI 2016. The study suggests that TMSVD is an efficient algorithm for the tomographic reconstruction of ionospheric electron density (IED).
Review of Robot-Assisted HIFU Therapy
Authors: Gunderman Anthony , Montayre Rudy , Ranjan Ashish , Chen Yue
Published: April 2023

This paper provides an overview of current robot-assisted high-intensity focused ultrasound (HIFU) systems for image-guided therapies. HIFU is a minimally invasive technique that relies on the thermo-mechanical effects of focused ultrasound waves to perform clinical treatments, such as tumor ablation, mild hyperthermia adjuvant to radiation or chemotherapy, vein occlusion, and many others. HIFU is typically performed under ultrasound (USgHIFU) or magnetic resonance imaging guidance (MRgHIFU), which provide intra-operative monitoring of treatment outcomes. Robot-assisted HIFU probe manipulation provides precise HIFU focal control to avoid damage to surrounding sensitive anatomy, such as blood vessels, nerve bundles, or adjacent organs. These clinical and technical benefits have promoted the rapid adoption of robot-assisted HIFU in the past several decades. This paper aims to present the recent developments of robot-assisted HIFU by summarizing the key features and clinical applications of each system. The paper concludes with a comparison and discussion of future perspectives on robot-assisted HIFU.
Wind Preview-Based Model Predictive Control of Multi-Rotor UAVs Using LiDAR
Authors: Mendez Arthur P. , Whidborne James F. , Chen Lejun
Published: April 2023

Autonomous outdoor operations of Unmanned Aerial Vehicles (UAVs), such as quadrotors, expose the aircraft to wind gusts causing a significant reduction in their position-holding performance. This vulnerability becomes more critical during the automated docking of these vehicles to outdoor charging stations. Utilising real-time wind preview information for the gust rejection control of UAVs has become more feasible due to the advancement of remote wind sensing technology such as LiDAR. This work proposes the use of a wind-preview-based Model Predictive Controller (MPC) to utilise remote wind measurements from a LiDAR for disturbance rejection. Here a ground-based LiDAR unit is used to predict the incoming wind disturbance at the takeoff and landing site of an autonomous quadrotor UAV. This preview information is then utilised by an MPC to provide the optimal compensation over the defined horizon. Simulations were conducted with LiDAR data gathered from field tests to verify the efficacy of the proposed system and to test the robustness of the wind-preview-based control. The results show a favourable improvement in the aircraft response to wind gusts with the addition of wind preview to the MPC; An 80% improvement in its position-holding performance combined with reduced rotational rates and peak rotational angles signifying a less aggressive approach to increased performance when compared with only feedback based MPC disturbance rejection. System robustness tests demonstrated a 1.75 s or 120% margin in the gust preview’s timing or strength respectively before adverse performance impact. The addition of wind-preview to an MPC has been shown to increase the gust rejection of UAVs over standard feedback-based MPC thus enabling their precision landing onto docking stations in the presence of wind gusts.
Sound of Daily Living Identification Based on Hierarchical Situation Audition
Authors: Wu Jiaxuan , Feng Yunfei , Chang Carl K.
Published: April 2023

One of the key objectives in developing IoT applications is to automatically detect and identify human activities of daily living (ADLs). Mobile phone users are becoming more accepting of sharing data captured by various built-in sensors. Sounds detected by smartphones are processed in this work. We present a hierarchical identification system to recognize ADLs by detecting and identifying certain sounds taking place in a complex audio situation (AS). Three major categories of sound are discriminated in terms of signal duration. These are persistent background noise (PBN), non-impulsive long sounds (NILS), and impulsive sound (IS). We first analyze audio signals in a situation-aware manner and then map the sounds of daily living (SDLs) to ADLs. A new hierarchical audible event (AE) recognition approach is proposed that classifies atomic audible actions (AAs), then computes pre-classified portions of atomic AAs energy in one AE session, and finally marks the maximum-likelihood ADL label as the outcome. Our experiments demonstrate that the proposed hierarchical methodology is effective in recognizing SDLs and, thus, also in detecting ADLs with a remarkable performance for other known baseline systems.