bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Penggunaan BPJS Kesehatan dalam Penanganan Balita Stunting di Lokus Stunting
Authors: Agustina Rakhmawati , Weken Merdekawati Evangli , Anggraeny Dyta
Published: January 2024

Latar Belakang: Asuransi kesehatan berbasis masyarakat semakin diintegrasikan ke dalam sistem kesehatan di Indonesia sehingga dimensi perlindungan sosial masuk ke Indeks Khusus Penanganan Stunting (IKPS). Jaminan Kesehatan Nasional yang diatur dengan Badan Penyelenggara Jaminan  Sosial (BPJS) Kesehatan memiliki jaminan program dalam penanganan stunting. Peluang kejadian stunting lebih besar pada balita yang tidak memiliki asuransi kesehatan.
Tujuan: Menggali implementasi penggunaan BPJS dalam penanganan balita stunting di daerah lokus stunting.
Metode: Penelitian kualitatif dengan pedekatan studi kasus di wilayah kerja Puskesmas Wori. Pemilihan informan dengan teknik snowballing sebanyak 9 informan yang terdiri dari staf puskesmas, perangkat desa, ibu balita stunting dan kader posyandu. Pengumpulan data dengan wawancara mandalam menggunakan perekam suara. Data diolah dan dianalisis secara tematik menggunakan software OpenCode.
Hasil: Pemerintah daerah melalui puskesmas dan pemerintah desa terus meningkatkan kepemilikan BPJS Kesehatan bagi balita stunting meskipun sudah ada jaminan kesehatan daerah. Balita stunting mendapatkan layanan rujukan ke dokter anak untuk skrining lanjutan namun tidak dapat terlaksana karena rendahnya kepemilikan BPJS Kesehatan. Faktor yang mempengaruhi karena tidak adanya Nomer Induk Kepegawaian (NIK) balita, proses yang lama dan persepsi ibu tentang bahaya stunting yang rendah. Anggapan pentingnya kepemilikan BPJS jika mereka mengalami gawat darurat dan perlu dirujuk ke rumah sakit. Bagi ibu penanganan stunting cukup dilakukan di tingkat puskesmas karena faktor pengetahuan dan kendala jarak ke fasilitas kesehatan lain.
Kesimpulan: Manfaat BPJS dapat dirasakan pada program penanganan balita stunting di wilayah kerja Puskesmas Wori namun perlu adanya koordinasi banyak pihak untuk mensosialisasikan dan pendampingan secara rutin kepada keluarga dengan balita stunting.
Augmented Reality dalam Budaya Kontemporer Perspektif Simulacra dan Hiperreality Jean Baudrillard
Authors: Thomas Rosario Babtista
Published: January 2024

Dewasa ini teknologi Augmented Reality (AR) berkembang pesat. AR mulai digunakan dalam berbagai kehidupan, seperti industri, kesehatan, transportasi dan militer. AR tidak hanya masuk ke dalam kehidupan, melainkan membawa manusia ke kemajuan teknologi. Di sisi lain, AR bisa menjebak manusia hidup dilema realitas. Jean Baudrillard berpandangan bahwa manusia modern hidup dalam simulasi. Bahkan manusia berupaya untuk hidup dalam hipereality yang membuat manusia hidup dalam dunia sesuai dengan imajinasinya. Maka dari itu muncul pertanyaan apakah AR membuat manusia hidup dalam sebuah simulasi atau sudah menjadi hiperrealitas? Bagaimana AR mempengaruhi budaya manusia kontemporer? Untuk menjawab ini, digunakanlah metode studi pustaka. Singkatnya ditemukanlah ada sebuah dilema antara yang riil dan yang maya. Dilema ini membuat hidup manusia menjadi mengambang. Di satu sisi, manusia kurang menerima realitas. Di sisi lain, hidup dalam maya tidak membuat diri menjadi otentik 100%. Yang riil dan maya memiliki kelebihannya masing-masing. Dengan memanfaatkan keduanya secara maksimal, hidup manusia menjadi lebih mudah dan segala permasalahan hidup dapat diselesaikan dengan lebih mudah.
 
Kata kunci: Augmented Reality; Jean Baudrillard; Simulasi; Realitas
Analisis Pendekatan Teori Keadilan John Rawls Dan Teori Utilitarianisme Jeremy Benthan Terhadap Konsep Pemenuhan Hak Korban Menurut Presfektif Viktimologi
Authors: Donna Karina Gladys
Published: January 2024

Dewasa ini, Pemenuhan hak korban dalam mencari keadilan diabaikan eksistensinya bahkan terdiskriminasi. Walaupun telah diatur dalam Undang-Undang Nomor 39 Tahun 1999 Tentang Hak Asasi Manusia dan Undang-Undang Dasar 1945, yang membahas perihal pemenuhan hak bagi setiap individu yang setara dan harus dipenuhi oleh negara, pemenuhan hak korban masih saja belum terpenuhi secara menyeluruh. Penyebab utamanya adalah sikap Aparat Penegak Hukum yang tidak kooperatif dalam melindungi dan memberikan pemenuhan hak bagi korban. Oleh sebab itu penelitian ini bertujuan untuk menelaah mengenai keadilan dan kemanfaatan yang merupakan tujuan dari adanya hukum, peneliti menganalisis dari teori keadilan John Rawls dan teori utilitarianisme Jeremy Bentham dan ditinjau menurut presfektif viktimologi yang mana berfokus pada pengalaman korban dan respon kebijakan negara terhadap korban. Jenis pepenelitian ini, merupakan penelitian normatif dengan analisis data kualitatif, analisis disajikan secara deskriptif untuk mengungkapkan fakta selengkap-lengkapnya. Hasil analisis pendekatan John Rawls dan Jeremy Bentham menurut presfektif viktimologi jika diterapkan secara benar maka dapat memenuhi keadilan dan melindungi hak korban, namun di Indonesia belum berjalan dengan maksimal karena kurangnya partisipasi aktif aparat penegak hukum dalam menjalankan tugasnya yaitu melindungi serta memberikan pemenuhan hak bagi korban.
A Study on the Constitutional Sprits and Human Rights
Authors:   Korean Association of Public Safety and Criminal Justice, Choi Sun Woo
Published: January 2024

In relation to social contract, T. Hobbes is significant in that he presented the prototype of modern contract theory, but there is a limits in that it is necessary to have a state dominated by a ruler with absolute power to guarantee human rights. In order to solve this problem, J. Locke proposed a new social contract theory by transferring the sovereignty from the state to the people. In this way, it can be seen that there is a big difference between the national identity and the human view proposed by Hobbes and Locke, and the way of guaranteeing human rights accordingly. If Hobbes is a legal positivism and pragmatism based on the state, Locke is approaching from the point of view of natural human rights before the state. The idea of natural rights is based on 「the Virginia Bill of Rights」(1776. 6), 「the Declaration of Independence」(1776. 7) in America, 「the Declaration of the Rights of Man and of the Citizen」(1789) in France, and 「the Declaration of the Universal Declaration of Human Rights」(1948) of the United Nations. It is also reflected in 「the Constitution of the Republic of Korea」(1948) and has related regulations. However, since the establishment of the government of the Republic of Korea, human rights have been infringed in the name of maintaining public well-being and order in the unstable political system and political dynamics. This problem has already been foreseen in the Constitution of the First Republic, which stipulates individual legal provisions related to the restriction of basic rights, and since then amendments to the Constitution have been made several times, but this problem has not been solved under the long-term military regime. Fortunately, the 6th Republic Constitution(1987~present), which was finally revised, is meaningful in that the governing system has been reorganized and the provisions for guaranteeing basic rights have been considerably newly established and added. However, if the ruling party to which the president belongs fails to secure a majority of seats in the National Assembly, there is no institutional mechanism to coordinate the instability of the state administration and political conflicts, which raises concerns that the fundamental rights of the people are not properly guaranteed. For this reason, the claim that the basic rights required by the times should be guaranteed through the amendment of the Constitution coexists with the prudence of this, and therefore, national and social consensus should be made once again at this time.
Relationship between criminal record and technical violation of offenders under electronic monitoring: Focusing on the moderating effect of the intervention program after the start of electronic monitoring
Authors:   Korean Association of Public Safety and Criminal Justice, Kim Su-Min , Jeon Yong-Jae
Published: January 2024

The purpose of this study is to verify whether the program that subjects of electronic monitoring receive after the start of supervision positively regulates their technical violation behavior. Data on technical violation of offenders under electronic monitoring over a time range from the introduction of the electronic supervision system to the point of collection in June 2020, and a sample of 5,859 people was randomly sampled. The analysis was conducted with SPSS 28.0, the general characteristics of the variables were confirmed through descriptive statistical analysis, and the moderating effect was confirmed through controlled regression analysis. As a result of the analysis, although psychotherapy had a subtle moderating effect on reducing the technical violation behavior of those subject to electronic supervision, it was not significant, and the number of times of guidance and supervision by officers had a significant moderating effect on the increase in technical violation behavior. These results show that the number of times of guidance and supervision in charge has a moderating effect on increasing compliance violation behavior, which is a result that conflicts with the hypothesis based on deterrence theory, but from the perspective of general strain theory that negative psychological states cause deviance and criminality. An explanation is possible. Therefore, rather than coercive supervision, it is believed that an approach such as forming a bond with the subject of electronic supervision is needed. This study sought to verify the effectiveness of a program intervened after electronic supervision, and by targeting violation of compliance requirements, which is a preliminary indicator before a crime occurs, as the dependent variable, it predicts recidivism itself in a state where a violation of the law has not yet occurred. This is where the significance of the study lies.
Modeling human wellbeing on a finite planet towards 2100 with Earth4All
Authors: Collste David , Barbour Felix , Callegari Beniamino , Cornell Sarah , Gaffney Owen , Spittler Nathalie , Stoknes Per Espen
Published: January 2024

How can wellbeing for all be reached while reducing risks of destabilizing the planet? This ambition underlies the 2030 Agenda but analyzing whether it is possible requires linking global socioeconomic developments with life-supporting Earth systems, incorporating feedback between them. Our new integrated systems model, Earth4All, enables exploration of plausible developments of human wellbeing and environmental pressures, 1980-2100. The relatively simple model focuses on quantifying and capturing high-level feedback between socioeconomic and environmental domains. It can analyze economic transformations towards increased wellbeing with reduced pressures on planetary boundaries. The model includes two key novelties: a social tension index and a wellbeing index, to track societal progress this century. Modeling results indicate that decision-making as usual likely leads to rising social tensions, worsening environmental pressures and declining wellbeing. We propose five turnarounds that in the model can shift the human world off the current trajectory, improve global wellbeing and ease environmental pressures.
Land potential assessment and trend-analysis using 2000–2021 FAPAR monthly time-series at 250 m spatial resolution
Authors: Hackländer Julia , Parente Leandro , Ho Yu-Feng , Hengl Tomislav , Simoes Rolf , Consoli Davide , Şahin Murat , Tian Xuemeng , Jung Martin , Herold Martin , Duveiller Gregory , Weynants Melanie , Wheeler Ichsani
Published: January 2024

The paper presents results of using remote sensing images and machine learning to map and assess land potential based on time-series of potential Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) composites. Land potential here refers to the potential vegetation productivity in the hypothetical absence of short–term anthropogenic influence, such as intensive agriculture and urbanization. Knowledge on this ecological land potential could support the assessment of levels of land degradation as well as restoration potentials. Monthly aggregated FAPAR time-series of three percentiles (0.05, 0.50 and 0.95 probability) at 250 m spatial resolution were derived from the 8-day GLASS FAPAR V6 product for 2000-2021 and used to determine long-term trends in FAPAR, as well as to model potential FAPAR in the absence of human pressure. CCa 3 million training points sampled from 12,500 locations across the globe were overlaid with 68 bio-physical variables representing climate, terrain, landform, and vegetation cover, as well as several variables representing human pressure including: population count, cropland intensity, nightlights and a human footprint index. The training points were used in an ensemble machine learning model that stacks three base learners (Extremely Randomized Trees, Gradient Descended Trees and Artificial Neural Network) using a linear regressor as meta-learner. The potential FAPAR was then projected by removing the impact of urbanization and intensive agriculture in the covariate layers. The results of strict cross-validation show that the global distribution of FAPAR can be explained with an R2 of 0.89, with the most important covariates being growing season length, forest cover indicator and annual precipitation. From this model, a global map of potential monthly FAPAR for the recent year (2021) was produced, and used to predict gaps in actual vs. potential FAPAR. The produced global maps of actual vs potential FAPAR and long-term trends were each spatially matched with stable and transitional land cover classes. The assessment showed large negative FAPAR gaps (actual lower than potential) for classes: urban, needle-leave deciduous trees, and flooded shrub or herbaceous cover, while strong negative FAPAR trends were found for classes: urban, sparse vegetation and rainfed cropland. On the other hand, classes: irrigated or post-flooded cropland, tree cover mixed leaf type, and broad-leave deciduous showed largely positive trends. The framework allows land managers to assess potential land degradation from two aspects: as an actual declining trend in observed FAPAR and as a difference between actual and potential vegetation FAPAR.
The Effectiveness of Digital Communication Media to Improve Adolescent Resilience Skills for Preventing Mental Health Problems: A Scoping Review Protocol
Authors: Rachmayanti Riris Diana , Dewi Fatwa Sari Tetra , Setiyawati Diana , Megatsari Hario , Diana Rian , Vinarti Retno Aulia
Published: January 2024

Background
The global databases reveal a high prevalence of mental health problems among adolescents, with 13.50% for ages 10–14 and 14.65% for ages 15–19. Successful coping depends on the risks and protective factors, and their interplay influencing resilience. Higher resilience correlates with lower mental health problems. Digital mental health holds promise for addressing mental health problems.
Purpose
This protocol serves as a framework for planning a scoping review to map the types and effectiveness of digital communication media in intervention to increase youth resilience.
Methods
Six steps to conduct a scoping review based on Arksey and O'Malley 2015 guidelines are applied: 1) defining the research questions by the PICO framework. The population is adolescent youth, young people, and teenagers. Intervention is digital health. The comparator is not using media or no digital media or non-digital. And outcome is resilience (coping mechanism, coping with stress) and well-being or positive mental health. 2) identifying relevant studies. We will identify all scoping reviews that are relevant and completed before 2023. 3) study selection. We will select articles for titles, abstracts, and full text by three independent reviewers based on the inclusion and exclusion criteria. 4) charting the data by Excel conducts essential information such as Study characteristics, description of digital health, variables relating to process, and research. 5) collating, summarising, and reporting the results. Synthesis focuses on (1) the typology of media used to intervene in adolescent resilience skills; and (2) the impact of media on adolescent resilience skills. Analysis by quantitative and qualitative, and 6) consultation with the research team or psychiatrist will be performed when additional data or information is needed.
Discussion
The results of the study will provide a comprehensive overview of commonly used digital media types and their effectiveness on youth resilience. Thus, the results of this scoping review protocol can serve as foundational evidence in determining further research or interventions.
Register Scoping Review :
The Scoping Review protocol was registered on Open Science Framework (OSF.IO/3CNRT)
Finite Element Models with Automatic Computed Tomography Bone Segmentation for Failure Load Computation
Authors: Saillard emile , Gardegaront Marc , Bermond Francois , Mitton David , Pialat jean-Baptiste , Confavreux Cyrille , Grenier Thomas , Follet Helene
Published: January 2024

Bone segmentation is an important step to perform biomechanical failure load simulations on in-vivo CT data of patients with bone metastasis, as it is a mandatory operation to obtain meshes needed for numerical simulations. Segmentation can be a tedious and time consuming task when done manually, and expert segmentations are subject to intra- and inter-operator variability. Deep learning methods are increasingly employed to automatically carry out image segmentation tasks. These networks usually need to be trained on a large image dataset along with the manual segmentations to maximize generalization to new images, but it is not always possible to have access to a multitude of CT-scans with the associated ground truth. It then becomes necessary to use training techniques to make the best use of the limited available data. In this paper, we propose a dedicated pipeline of preprocessing, deep learning based segmentation method and post-processing for in-vivo human femurs and vertebrae segmentation from CT-scans volumes. We experimented with three U-Net architectures and showed that out-of-the-box models enable automatic and high-quality volume segmentation if carefully trained. We compared the failure load simulation results obtained on femurs and vertebrae using either automatic or manual segmentations and studied the sensitivity of the simulations on small variations of the automatic segmentation. The failure loads obtained using automatic segmentations were comparable to those obtained using manual expert segmentations for all the femurs and vertebrae tested, demonstrating the effectiveness of the automated segmentation approach for failure load simulations.
Dynamic clade transitions and the influence of vaccine rollout on the spatiotemporal circulation of SARS-CoV-2 variants in São Paulo, Brazil
Authors: Nogueira Maurício , Banho Cecília , Marques Beatriz , Sacchetto Livia , Lima Ana Karoline , Parra Maisa Carla , Lima Alex , Ribeiro Gabriela , Martins Antonio , Barros Claudia , Elias Maria , Sampaio Sandra , Slavov Svetoslav , Rodrigues Evandra , Santos Elaine , Covas Dimas , Kashima Simone , Brassaloti Ricardo , Petry Bruna , Clemente Luan , Coutinho Luiz , Assato Patricia , Costa Felipe , Souza-Neto Jayme , Grotto Rejane , Poleti Mirele , Lesbon Jessika , Mattos Elisangela , Fukumasu Heidge , Giovanetti Marta , Alcantara Luiz Carlos , Rahal Paula , Araújo João , Spilki Fernando , Althouse Benjamin , Vasilakis Nikos
Published: January 2024

Since 2021, the emergence of variants of concern (VOC) has led Brazil to experience record numbers of in COVID-19 cases and deaths. The expanded spread of the SARS-CoV-2 combined with a low vaccination rate has contributed to the emergence of new mutations that may enhance viral fitness, leading to the persistence of the disease. Due to limitations in the real-time genomic monitoring of new variants in some Brazilian states, we aimed to investigate whether genomic surveillance, coupled with epidemiological data and SARS-CoV-2 variants spatiotemporal spread in a smaller region, can reflect the pandemic progression at a national level. Our findings revealed three SARS-CoV-2 variant replacements from 2021 to early 2022, corresponding to the introduction and increase in the frequency of Gamma, Delta, and Omicron variants, as indicated by peaks of the Effective Reproductive Number (Reff). These distinct clade replacements triggered two waves of COVID-19 cases, influenced by the increasing vaccine uptake over time. Our results indicated that the effectiveness of vaccination in preventing new cases during the Delta and Omicron circulations was six and eleven times higher, respectively, than during the period when Gamma was predominant, and it was highly efficient in reducing the number of deaths. Furthermore, we demonstrated that genomic monitoring at a local level can reflect the national trends in the spread and evolution of SARS-CoV-2.
The Prognosis of Pediatric Intensive Care Unit Patients Can Be Affected by Gamma Glutamyl transferase and Uric Acid Levels: A systematic review with Meta-Analysis.
Authors: Baloch Muhammad Daniyal , Abduhaer Abulaiti , Hairula Nadire
Published: January 2024

Background: Elevated Gamma Glutamyl transferase (GGT) and uric acid levels have been associated with worse outcomes in critically ill patients, but their predictive value in Pediatric Intensive Care Unit (PICU) patients is unclear. We conducted a systematic review and meta-analysis to evaluate the association between GGT/uric acid and mortality in PICU patients.
Methods: PubMed, Embase and Cochrane Library were searched for observational studies examining the association between GGT/uric acid levels and mortality in PICU patients. Pooled risk ratios (R.R.) with 95% confidence intervals (CI) were calculated using random-effects models.
Results: 8 studies with 2,134 patients were included. Elevated GGT was associated with significantly higher mortality risk (RR 1.86, 95% CI 1.34-2.58). The association remained significant when restricted to multivariate analyses (RR 1.95, 95% CI 1.17-3.26). Elevated uric acid levels were also associated with higher mortality (RR 1.97, 95% CI 1.33-2.90). Significant heterogeneity was present.
Conclusions: Elevated Gamma Glutamyl transferase (GGT) and uric acid levels are associated with higher mortality risk in Pediatric Intensive Care Unit (PICU) patients. These biomarkers may assist in risk stratification, although additional studies are needed to confirm these findings.
The stomatin-like protein StlP organizes membrane microdomains to govern polar growth in filamentous actinobacteria under hyperosmotic stress
Authors: Claessen Dennis , Zhong Xiaobo , Baur Sarah , Ongenae Veronique , Egido Guillermo Guerrero , Shitut Shraddha , Du Chao , Vijgenboom Erik , Wezel Gilles van , Brava Victor Carrion , Briegel Ariane , Bramkamp Marc
Published: January 2024

The cell wall represents an essential structure conserved among most bacteria, playing a crucial role in growth and development. While extensively studied model bacteria have provided insights into cell wall synthesis coordination, the mechanism governing polar growth in actinobacteria remains enigmatic. Here we identify the stomatin-like protein StlP as a pivotal factor essential for orchestrating polar growth in filamentous actinobacteria under hyperosmotic stress. StlP facilitates the establishment of a membrane microdomain with increased membrane fluidity, a process crucial for maintaining proper growth. The absence of StlP leads to branching of filaments, aberrant cell wall synthesis, thinning of the cell wall, and the extrusion of cell wall-deficient cells at hyphal tips. StlP interacts with key components of the apical glycan synthesis machinery, providing protection to filaments during apical growth. Introduction of StlP in actinobacteria lacking this protein enhances polar growth and resilience under hyperosmotic stress, accompanied by the formation of a membrane microdomain. Our findings imply that stomatin-like proteins, exemplified by StlP, confer a competitive advantage to actinobacteria encountering hyperosmotic stress. Given the widespread conservation of StlP in filamentous actinobacteria, our results propose that the mediation of polar growth through membrane microdomain formation is a conserved phenomenon in these bacteria.
USP3 promotes DNA damage response and chemotherapy resistance through stabilizing and deubiquitinating SMARCA5 in prostate cancer
Authors: xu songhui , Li Sheng , Xiong Situ , Li Zhongqi , Yang Lin , Yang Hailang , Xiong Yunqiang , Zhan Xiangpeng , Dong Qianxi , Hu Hongji , Zheng Fuchun , Wan Hao , Liu Xiaoqiang , Wang Zhipeng , Wu Shuyu , Du Yuanzhuo , Guo Biao , Xiong Jing , Pan Wang , Guo Ju , Fu Bin
Published: January 2024

The chromatin-remodeling enzyme SMARCA5 plays a key role in DNA-templated events including transcription, DNA replication, and DNA repair. Loss of function of the SMARCA5 can cause neurodevelopmental disorder and Williams syndrome. However, the molecular mechanism underlying the regulation of SMARCA5 in prostate cancer remains largely elusive. Here, we report that the deubiquitinating enzyme USP3 directly interacts with SMARCA5 and removes K63-linked polyubiquitination of SMARCA5 to maintain its stability, which promotes DNA damage repair and chemotherapy resistance. Depletion of USP3 or SMARCA5 promoted PCa cells sensitive to docetaxel and overexpression of USP3 restored the cells resistance to docetaxel treatment in SMARCA5 silenced cells in vitro and vivo. Clinically, USP3 was significantly up-regulated in prostate cancer tissues and positively associated with SMARCA5 expression. Collectively, our findings uncover a novel molecular mechanism for the USP3-SMARCA5 axis in regulating DSB repair with an important role in chemotherapy response in human prostate cancers, highlighting that targeting USP3-SMARCA5 axis could be a valuable strategy to treat USP3/SMARCA5-overexpressing chemotherapy-resistant patients and improve drug treatment.
A rare case of combined endometrioid adenocarcinoma arising from uterine adenomyosis and clear cell carcinoma arising from parametrical deep endometriosis
Authors: Zhou Cailu , Luo Xiaojing , Tang Mengjie , Luo Fangyuan , Liao Zhi
Published: January 2024

Background Carcinomatous changes from the ectopic endometrial glands in endometriosis have been reported in many studies, but malignant transformation from uterine adenomyosis/adenomyoma is rare. And clear cell-like adenocarcinoma represents a seldom-encountered malignant pathological variant of ectopic endometrium. Case presentation This case report presents a case of a 44-year-old nulliparous woman begun with abdominal pain and intestinal obstruction. Past medical history showed laparoscopic ovarian endometriotic cyst excision. Ultrasound indicated adenomyoma and a parametrical hypoechoic nodule with abundant blood flow signals and unclear boundaries. Deep invasive endometriosis was considered preoperatively. The patient underwent laparoscopic subextensive hysterectomy and bilateral adnexa resection. Chocolate cyst-like lesion was observed in the parametral lesion. Postoperative pathological examinations suggested endometrioid adenocarcinoma arising from eutropic endometrium and adenomyoma. Left parametrical lesions suggested poorly differentiated endometrioid adenocarcinoma combined with clear cell carcinoma. CD10 + endometrial stromal cells were observed surrounding tumor cell masses. The patient underwent subsequent transabdominal tumor cell reduction surgery and chemotherapy. Combined with surgical founding and pathological characters of the left parametrical adenocarcinoma, the parametrial lesions were more likely to be carcinomatous changes of the original deep endometriosis. Conclusion We herein present a rare case of combined endometrioid adenocarcinoma arising from uterine adenomyosis and clear cell carcinoma arising from parametrical deep endometriosis that may help inspire additional studies in the future.
Three-Dimensional Measurement of Face as a Novel Distinguishing Tool in Facioscapulohumeral Muscular Dystrophy
Authors: HANGUL Ceren , ÖZSOY Umut , HİZAY Arzu , KARAUZUM Sibel BERKER , FIRAT Mehmet Ziya , UYSAL Hilmi , SAUER Elizabeta
Published: January 2024

Background
Facioscapulohumeral dystrophy (FSHD) almost always affects the muscles of the face. Quantiative evalution of face is essential for the identification of severity in the facial region. The aim of this study is to evaluate facial involvement of FSHD patients with three-dimensional(3D) scanning to answer these questions: (Q1) Are the facial 3D evaluations of FSHD patients different compared to healthy individuals? (Q2) Do 3D evaluations correlate with genetic mutation and clinical severity of the disease?
Methods
The 3D facial scanning was performed in three axes coordinate system. Outcome variables were intensity and asymmetry estimations of those facial expressions; eyebrow elevation, maximal closing of the eyes, maximal showing of the teeth, whistling, and happy. Genetic diagnosis was performed with southern blot analysis to reveal D4Z4 repeat contraction on 4q35 (D4Z4-RU). Clinical severity score (CSS) was determined via neurological examination. For Q1, intensity and asymmetry related 3D variables were compared between the control and FSHD groups. For Q2, the correlation analysis was performed between intensity related 3D variables and genetic mutation and clinical severity. The level of significance had been set to p ≤ 0. 05.
Results
Twenty-one healthy controls (57.1% female) and 12 FSHD patients (58.3% female) were included. Significantly different (p < 0.002 and < 0.001) facial expressions were; the intensity of whistling, maximal closing of the eyes and happy expressions. There was no significant difference in asymmetry related measurements. No correlation between facial variables with D4Z4-RU and CSS was detected.
Conclusions
The 3D method can be used as a quantitative evaluation method in diseases manifested by impaired mimic muscle functions such as FSHD.
Modeling the Elastic Collision of Nanoparticle with Erytrocite: Viscoelastic Effects on Angular Dispersion
Authors: Rivera Ángela Johana Riaño , Barrantes Laura María Roa , Rodriguez Diego Julian
Published: January 2024

To achieve effective drug administration and minimize toxicity, it is crucial to predict the movement and trajectory of nanoparticles, or other nanodevices, when they interact with blood components. In this study, a dispersion model was developed for the interaction between a nanoparticle (NP) and a red blood cell (RBC) considering an elastic collision, assuming that RBCs are the main scattering center in drug delivery through the bloodstream. To analyze the model, the viscoelastic characteristics of the RBC membrane were highlighted, which allowed for the study of interaction in the collision interval through classical molecular dynamics. The kinetic and energetic behavior of the interaction was described, taking into account the drag force exerted by the RBC surface on the nanoparticle and the viscoelastic force that causes a non-linear displacement of the nanoparticle. Additionally, an analytical model based on the trajectory vectors before and after collision, associated with the position and velocity vectors of the nanoparticle, was proposed. This allowed for obtaining the angular dispersion profiles and quantifying the differential effective collision section between the particle and the RBC. The results showed that dispersion depends on the biconcave and symmetrical geometry of the RBC, as well as the velocity and direction of the nanoparticle movement.
Proposal for a Protocol for Adaptation of the Oral Environment Prior to Major Surgery: A Series of Cases.
Authors: COSTA RAQUEL COELHO NETTO DA , Feitosa Telcilene Martins , de Sousa Franklin Monteiro , FERREIRA MEIRE COELHO
Published: January 2024

The intensive involvement of the dentistry team as a multidisciplinary strategy in the preoperative period showed an accelerated recovery of patients undergoing oncological surgery. Protocols were adopted that included oral preparation before surgery, which brought good results in the postoperative period for these patients. However, perioperative oral practices as a protective factor have not yet been well understood and need to be further studied.
OBJECTIVE: to present a medical-surgical care protocol for patients, with adaptation of the oral environment prior to major orthopedic surgeries, specifically hip arthroplasty, in a university hospital. SAMPLE: 23 patients who underwent an outpatient consultation with the orthopedic surgeon and were referred to the hospital's dentistry service to adapt the oral environment prior to hip arthroplasty surgery.
MATERIAL AND METHOD: Case series study in which the hospital records of 23 patients were evaluated to investigate the main postoperative complications found in a group where 100% of patients underwent previous mouth preparation. For this purpose, dental records were collected with patient data such as the patient's medical record number, odontogram and report on the execution of the dental procedures performed. Two years after the adoption of this system, the patients' medical records were coded and analyzed by a researcher who, using the hospital's computer system, verified the length of stay for each patient, the execution of the procedure in the surgical center and the main reports of complications in each patient. patient such as postoperative infection, pneumonia, admission to an intensive care unit as well as the hospital discharge report.
RESULTS: We observed that 100% of patients who underwent previous mouth preparation, none contracted pneumonia; There were no reports of dental loss or trauma during intubation or throughout the hospitalization period; The average length of stay was 9 days; There was one admission to the intensive care unit with a history of sepsis, cardiac arrest and subsequent death; Among the most reported postoperative complications, in addition to pain, we found volunteers with infection at the surgical site and two volunteers with deep vein thrombosis; 15 volunteers were discharged from hospital.
Abnormal spinal curvature and influencing factors in children and adolescents in Hangzhou
Authors: Zhao Lijuan , Jiang Xiujun , Zhang Wenhui , Hao Li , Wu Shangxi , Zhang Yuting , Xu Hong , Zhu Bing
Published: January 2024

Aims To investigate the prevalence and influencing factors of abnormal spinal curvature among primary and secondary school students in Hangzhou city, and provide ideas for the formulation of abnormal spinal curvature prevention and control measures. Methods Using a stratified cluster random sampling method, 5,652 students of primary and junior high school from 24 schools were investigated via questionnaires and abnormal spinal curvature screening in Hangzhou. Univariate and multivariate logistic regression were used to screen possible risk factors of abnormal spinal curvature. Results The overall abnormal spinal curvature rate was 2.23%, with the increase of the school period, the prevalence of abnormal spinal curvature among students showing upward trend (χ2 = 90.679,P<0.001). The abnormal spinal curvature prevalence in boys is higher than that in girls (χ2 = 0.507,P = 0.477); the prevalence of abnormal spinal curvature in urban students is higher than that in suburban students (χ2 = 49.954,P<0.001). Accommodation at school is independently associated with higher prevalence of abnormal spinal curvature. Moreover, outdoor activity time ≥ 2h per day in the past one week, overweight, always maintain correct sitting and standing posture are protective factors for abnormal spinal curvature. Conclusions The abnormal spinal curvature prevalence among children and adolescents in Hangzhou is at a relatively low level, and is affected by most factors such as accommodation at school, outdoor activity time, Body Mass Index, sitting and standing posture, needing collaboration of school, students and parents to strengthen screening and prevention.
The curvature modeling for the double layered clad plate by asymmetric rolling with different diameters
Authors: Jiang Lianyun , Liang Jiale , Chen Yafei , Shi Jianhui , Ma Lifeng
Published: January 2024

The plate curvature model plays an important role in the prediction and control of the double layered clad plate. However, there is currently no such a fast, precise and stable plate curvature model, and the actual shear stress on the cross section is uneven distributed actually which is conflicted with the uniform assumption of the traditional model. Based on the non-uniform distribution, this paper innovatively presents a theoretical plate curvature model using the flow function method and the upper bound method together without the complex stress analysis. The inlet boundary conditions of the model are more accurate modified and optimized as nonlinear functions. The velocity field and strain rate field were built depending on the flow function field. The plastic deformation, shear and friction power were developed by the five-node Gauss-Legendre quadrature method. The post-rolling strain model was obtained by integrating the positive strain rate and shear strain rate with time. The curvature model was constructed by calculating the curvature due to linear and shear strain differences. To demonstrate the validity of the theoretical model, the experiments and the simulation were conducted. The results showed that the relative deviation of the numerical values va and vb is less than 10.0%, accounting for 95.1% and 95.4%, compared with theoretical values. The shear power difference between layer a and b is the main reason for bending. The bending phenomenon appeared the outlet section of the plate, and the velocity difference provided the shear stress required for bending. The increase of the diameter ratios lead to the increase of the shear strain difference and shear power, and it leads to an increase in the total curvature. To certify the precision of the curvature model, the deviation of the theoretical peak curvature values is 12.05%, and the average deviation is 5.92%, compared with the simulation and experiments. The model can quickly grasp the affecting law of key rolling process parameters on curvature, which will provide theoretical and technical basis for rolling process.
Effects of pretreatment on the microcharacterization and fermentation of bamboo shoot shells
Authors: Zhou Tengmian , Li Meiqun , Zeng Baiquan , Chen Jinjiao , Xiang Chun , Hu Chunfeng , Yang Ming , Meng Yong
Published: January 2024

This study focuses on the pretreatment and characterization of natural fibers from the bamboo shoot shell(BSS) of Phyllostachys hterocycla, a species of bamboo, to determine their suitability as biorefining materials. The discarded bamboo shoot shell was used for fiber extraction, and the resulting fibers were analyzed for their physical, chemical, and microstructure properties.The Fourier transform infrared spectroscopy,X-ray diffraction spectra and scanning electron microscopy also confirmed that a mixture of sodium hydroxide immersion plus high-pressure steam treatment allowed the cellulose structure to be disrupted, providing more adsorption sites for cellulases.Gas Chromatography Mass Spectrometry (GC-MS) also showed that the internal structure of the fibers was eluted.The cellulaseproduced by (Trichoderma green and Aspergillus niger) reducing sugar yields produced also increased by 267.69% and 250.57%, compared to unpretreated BSS fibers.This strategy may apply to many industries, especially biorefining and lignocellulose biotransformation technology.
Diagnosis and management of false-positive intracranial aneurysms: a systematic review and illustrative cases.
Authors: Konovalov Anton , Gadzhiagaev Vadim , Artemyev Anton , Okishev Dmitriy , Pilipenko Yuri , Grebenev Fyodor , Eliava Shalva
Published: January 2024

Purpose: To systematically review existing data on a false-positive diagnosis of an intracranial aneurysms and associated risks.
Methods: A literature search in two databases (PubMed and Web of Science) using keywords "mimicking an intracranial aneurysm", "presenting as an intracranial aneurysm", "false positive intracranial aneurysms," and "neurosurgery” was conducted. We also presented two illustrative cases of patients operated on due to false diagnosis.
Results: A total of 243 papers were found in the initial search in two databases. Sixteenpapers (including 20 patients) were included in the final analysis. There were 10 women and 10 men. The most common location of false-positive aneurysms was the bifurcation of the middle cerebral artery. In the posterior circulation, false-positive aneurysms were identified either on the basilar artery, or at the vertebro-basilar junction. Artery occlusion with vascular stump formation was the most common cause of false intracranial aneurysm diagnosis (55.0%). Most often, this variant was detected at the MCA bifurcation (63.6%). Other causes included infundibular widening, fenestration, arterial dissection, contrast extravasation, venous varix.
Conclusion: Surgical interventions for false-positive aneurysms are an underestimated problem in vascular neurosurgery. Despite extremely rare published clinical observations, the actual frequency of erroneous surgical interventions for false-positive aneurysms is unknown.
A Deep Learning Approach to Hard Exudates Detection and Disorganization of Retinal Inner Layers Identification on OCT images
Authors: Toto Lisa , Romano Anna , Pavan Marco , Degl’Innocenti Dante , Olivotto Valentina , Formenti Federico , Viggiano Pasquale , Midena Edoardo , Mastropasqua Rodolfo
Published: January 2024

The purpose of the study was to detect to detect Hard Exudates (HE) and classify Disorganization of Retinal Inner Layers (DRIL) implementing a Deep Learning (DL) system on optical coherence tomography (OCT) images of eyes with diabetic macular edema (DME). We collected a dataset composed of 442 OCT images on which we annotated 6847 HE and the presence of DRIL. We defined a complex operational pipeline to implement data cleaning and image transformations, and train two DL models. We exploited state-of-the-art neural network architectures (Yolov7, ConvNeXt, RegNetX) and advanced techniques to aggregate the results (Ensemble learning, Edge detection) and obtain a final model. In order to evaluate our DL system on the HE detection we calculated the AP@0.5, Precision and Recall, while for the DRIL classification, we computed the overall Accuracy, Sensitivity, Specificity, Area Under the ROC Curve, and Area Under the Precision-Recall values. Kappa coefficient and P-value were used to prove the statistical significance level. The DL approach reached good performance in detecting HE and classifying DRIL. Regarding HE detection the model got an AP@0.5 score equal to 34.4% with Precision of 48.7% and Recall of 43.1%; while for DRIL classification we obtained an Accuracy of 91.1% with Sensitivity and Specificity both of 91,1% and AUC and AUPR values equal to 91%. The P-value was lower than 0.05 and the Kappa coefficient was 0.82. The DL models proved to be able to identify HE and DRIL in eyes with DME with a very good accuracy and all the metrics calculated confirmed the system performance. Our DL approach demonstrated to be a good candidate as a supporting tool for ophthalmologists in OCT images analysis.
Stunting among children under five years with disabilities in Bugesera District, Rwanda: prevalence and associated factors
Authors: Emmanuel Nkurunziza , Erigene Rutayisire , Kevin Nwanna Uchechukwu , Habtu Michael
Published: January 2024

Background
Global burden of disease report shows that 49.8 million children under the age of five worldwide suffer from disabilities together with other difficulties. The most prevalent of these problems is stunting, which negatively impacts children's physical health, growth, mental development, and resilience to disease. This heightened burden is attributed to inadequate food intake, exacerbating their nutritional status and worsening their overall well-being, particularly in developing countries like Rwanda. Thus, the primary objective of this study was to evaluate the prevalence of stunting and its associated factors among disabled children under the age of five in Bugesera district, Rwanda.
Method
This was a cross-sectional descriptive study. A multistage sampling technique was applied where the first eight sectors out of 15 were randomly selected then participants were selected using a simple random technique based on probability proportion to size (PPS) in each sector. Weight was obtained using a standard electronic balance scale while height was measured using a wooden height board and children less than 24 months lengths were obtained in recumbent position. Height for age was classified according to WHO z-score standards with the help of the zscore06 stata function. Independent factors including sociodemographic and socio-economic factors were obtained through an administered questionnaire. The description of independent variables was done using frequencies and percentages. The chi-square (χ2) test was applied to determine the associated factors of stunting among children with disabilities. Multivariable logistic regression analysis was performed to test the strength of the association. The significance level was set at 5%.
Results
In total 265 children were recruited and the majority were aged between 25-59 months and more than half 59.66% were males. The prevalence of stunting among disabled children under the age of five was 44.91%. The factors positively associated with stunning after running multiple logistic regression were: age 25-59 months (aOR = 4.18 [95% CI: 1.71 - 10.23]), incomplete child immunization (aOR = 4.4 [95% CI: 1.16 - 16.69]), and rural residence (aOR = 3.08 [95% CI: 1.05 - 8.99]. However, the father’s education in primary school was a protective factor compared to those with no education ([aOR=0.52 [95% CI: 0.30- 0.90]).
Conclusion
The prevalence of stunting among under-five children with disabilities is high and being in preschool age, incomplete child immunization, and living in rural are associated with high risk of stunting among these children. There is a need to address stunting among disabled children through a strong program on parental education about nutritional guidance and support, as well as providing high-quality healthcare including child full immunization.
A robust approach for computing solutions of fractional-order two-dimensional Helmholtz equation
Authors: Nadeem Muhammad , Li Zitian , Kumar Devendra , Alsayaad Yahya
Published: January 2024

In ocean engineering, the Helmholtz equation plays a crucial role in the study of wave propagation, underwater acoustics, and the behavior of waves in the ocean environment. The equation is used to describe how waves, such as sound waves or electromagnetic waves, propagate through the ocean. This paper presents the Elzaki transform residual power series method (ET-RPSM) for the analytical treatment of fractional-order Helmholtz equation. To develop this scheme, we combine the Elzaki transform (ET) with the residual power series method (RPSM). The fractional derivatives are described in the Caputo sense. The ET is capable of handling the fractional order and turning the problems into a recurrence form. We implement the RPSM in such a way that this recurrence relation generates the results in the form of an iterative series. Some numerical applications are considered to demonstrate the efficiency and authenticity of this scheme. The obtained series are determined very quickly and converge to the exact solution only after a few iterations. Graphical plots and absolute error are shown to observe the authenticity of this suggested approach.