bluuebunny/crossref_metadata_2025 huggingface dataset:
Cutaneous squamous cell carcinoma manifesting as follicular isthmus cysts in a cat
Authors: Layne Elizabeth A , Graham Melissa
Published: February 2016

Case summary

A 9-year-old spayed female domestic shorthair cat was examined for swelling of the right upper lip. The cat had been receiving oral ciclosporin A for eosinophilic plaques. The swelling appeared clinically and cytologically consistent with an abscess; exudate was cultured and treatment consisted of antibiotic therapy and surgical curettage. Five months of antibiotic therapy with three separate surgical treatments resulted in minimal improvement; three separate biopsy samples demonstrated epithelial cysts with severe dermal inflammation. Swelling and drainage of purulent material from the affected lip persisted and progressed to involve the left upper lip. Euthanasia was elected 13 months after initial examination due to disease progression. On necropsy, histopathology demonstrated multiple isthmus cysts intermixed with squamous cell carcinoma (SCC).

Relevance and novel information

The clinical and histopathologic features were unusual for feline cutaneous SCC. The cystic nature and lack of epidermal involvement suggest the tumor arose from non-epidermal squamous cells such as follicular isthmus or ductal epithelium. There is a pattern of SCC recognized in human renal transplant patients with features of epidermal inclusion cysts. These features have not been previously reported in SCC from a cat.
Should IGHV status and FISH testing be performed in all CLL patients at diagnosis? A systematic review and meta-analysis
Authors: Parikh Sameer A. , Strati Paolo , Tsang Mazie , West Colin P. , Shanafelt Tait D.
Published: February 2016

Since the first description of the natural history of chronic lymphocytic leukemia (CLL) by David Galton in 1966, the considerable heterogeneity in the disease course has been well recognized. The Rai and Binet staging systems described ∼40 years ago have proven to be robust prognostic tools. Over the past 2 decades, several novel biological, genetic, and molecular markers have been shown to be useful adjuncts to the Rai and Binet staging systems. In this systematic review, we examined the role of immunoglobulin heavy-chain variable region gene (IGHV) mutation status and genetic abnormalities determined by interphase fluorescence in situ hybridization (FISH) in patients with newly diagnosed CLL. The cumulative evidence presented in this systematic review is sufficient to recommend that FISH and IGHV be performed as standard clinical tests for all patients with newly diagnosed CLL in those countries with the resources to do so. In addition to clinical stage, these parameters could represent the minimal standard initial prognostic evaluation for patients with CLL. This approach will allow the application of powerful, recently developed prognostic indices (all of which are dependent on IGHV and FISH results) to all patients with newly diagnosed CLL.
The role of structural parameters in DNA cyclization
Authors: Alexandrov Ludmil B. , Bishop Alan R. , Rasmussen Kim Ø. , Alexandrov Boian S.
Published: February 2016

Background

The intrinsic bendability of DNA plays an important role with relevance for myriad of essential cellular mechanisms. The flexibility of a DNA fragment can be experimentally and computationally examined by its propensity for cyclization, quantified by the Jacobson-Stockmayer J factor. In this study, we use a well-established coarse-grained three-dimensional model of DNA and seven distinct sets of experimentally and computationally derived conformational parameters of the double helix to evaluate the role of structural parameters in calculating DNA cyclization.

Results

We calculate the cyclization rates of 86 DNA sequences with previously measured J factors and lengths between 57 and 325 bp as well as of 20,000 randomly generated DNA sequences with lengths between 350 and 4000 bp. Our comparison with experimental data is complemented with analysis of simulated data.

Conclusions

Our data demonstrate that all sets of parameters yield very similar results for longer DNA fragments, regardless of the nucleotide sequence, which are in agreement with experimental measurements. However, for DNA fragments shorter than 100 bp, all sets of parameters performed poorly yielding results with several orders of magnitude difference from the experimental measurements. Our data show that DNA cyclization rates calculated using conformational parameters based on nucleosome packaging data are most similar to the experimental measurements. Overall, our study provides a comprehensive large-scale assessment of the role of structural parameters in calculating DNA cyclization rates.
GenAp: a distributed SQL interface for genomic data
Authors: Kozanitis Christos , Patterson David A.
Published: February 2016

Background

The impressively low cost and improved quality of genome sequencing provides to researchers of genetic diseases, such as cancer, a powerful tool to better understand the underlying genetic mechanisms of those diseases and treat them with effective targeted therapies. Thus, a number of projects today sequence the DNA of large patient populations each of which produces at least hundreds of terra-bytes of data. Now the challenge is to provide the produced data on demand to interested parties.

Results

In this paper, we show that the response to this challenge is a modified version of Spark SQL, a distributed SQL execution engine, that handles efficiently joins that use genomic intervals as keys. With this modification, Spark SQL serves such joins more than 50× faster than its existing brute force approach and 8× faster than similar distributed implementations. Thus, Spark SQL can replace existing practices to retrieve genomic data and, as we show, allow users to reduce the number of lines of software code that needs to be developed to query such data by an order of magnitude.
Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice
Authors: Wang Xiaomei , Tian Jinglin , Yong Ken-Tye , Zhu Xuedan , Lin Marie Chia-Mi , Jiang Wenxiao , Li Jiefeng , Huang Qijun , Lin Guimiao
Published: February 2016

Background

The toxicity of CdSe/ZnS quantum dots (QDs) in the environment and biological systems has become a major concern for the nanoparticle community. However, the potential toxicity of QDs on immune cells and its corresponding immune functions remains poorly understood. In this study, we investigated the immunotoxicity of CdSe/ZnS QDs using the in vitro in macrophages and lymphocytes and in vivo in BALB/c mice.

Results

Our results indicated that macrophages treated with 1.25 or 2.5 nM QDs exhibited decreased cell viability, increased levels of reactive oxygen species (ROS), elevated apoptotic events, altered phagocytic ability, and decreased release of TNF-α and IL-6 by upon subsequent stimulation with Lipopolysaccharide (LPS). In contrast, lymphocytes exposed to QDs exhibited enhanced cell viability, increased release of TNF-α and IL-6 following exposure with CpG-ODN, and decreased transformation ability treatment in response to LPS. To study the in vivo effects in mice, we showed that QDs injection did not cause significant changes to body weight, hematology, organ histology, and phagocytic function of peritoneal macrophages in QDs-treated mice. In addition, the QDs formulation accumulated in major immune organs for more than 42 days. Lymphocytes from QDs-treated mice showed reduced cell viability, changed subtype proportions, increased TNF-α and IL-6 release, and reduced transformation ability in response to LPS.

Conclusions

Taken together, these results suggested that exposures to CdSe/ZnS QDs could suppress immune-defense against foreign stimuli, which in turn could result in increased susceptibility of hosts to diseases.
White matter tract integrity in treatment-resistant gambling disorder
Authors: Chamberlain Samuel R. , Derbyshire Katherine , Daws Richard E. , Odlaug Brian L. , Leppink Eric W. , Grant Jon E.
Published: February 2016

Background

Gambling disorder is a relatively common psychiatric disorder recently re-classified within the DSM-5 under the category of ‘substance-related and addictive disorders'.

Aims

To compare white matter integrity in patients with gambling disorder with healthy controls; to explore relationships between white matter integrity and disease severity in gambling disorder.

Method

In total, 16 participants with treatment-resistant gambling disorder and 15 healthy controls underwent magnetic resonance imaging (MRI). White matter integrity was analysed using tract-based spatial statistics.

Results

Gambling disorder was associated with reduced fractional anisotropy in the corpus callosum and superior longitudinal fasciculus. Fractional anisotropy in distributed white matter tracts elsewhere correlated positively with disease severity.

Conclusions

Reduced corpus callosum fractional anisotropy is suggestive of disorganised/damaged tracts in patients with gambling disorder, and this may represent a trait/vulnerability marker for the disorder. Future research should explore these measures in a larger sample, ideally incorporating a range of imaging markers (for example functional MRI) and enrolling unaffected first-degree relatives of patients.
The yjdF riboswitch candidate regulates gene expression by binding diverse azaaromatic compounds
Authors: Li Sanshu , Hwang Xue Ying , Stav Shira , Breaker Ronald R.
Published: February 2016

The yjdF motif RNA is an orphan riboswitch candidate that almost exclusively associates with the yjdF protein-coding gene in many bacteria. The function of the YjdF protein is unknown, which has made speculation regarding the natural ligand for this putative riboswitch unusually challenging. By using a structure-probing assay for ligand binding, we found that a surprisingly broad diversity of nitrogen-containing aromatic heterocycles, or “azaaromatics,” trigger near-identical changes in the structures adopted by representative yjdF motif RNAs. Regions of the RNA that undergo ligand-induced structural modulation reside primarily in portions of the putative aptamer region that are highly conserved in nucleotide sequence, as is typical for riboswitches. Some azaaromatic molecules are bound by the RNA with nanomolar dissociation constants, and a subset of these ligands activate riboswitch-mediated gene expression in cells. Furthermore, genetic elements most commonly adjacent to the yjdF motif RNA or to the yjdF protein-coding region are homologous to protein regulators implicated in mitigating the toxic effects of diverse phenolic acids or polycyclic compounds. Although the precise type of natural ligand sensed by yjdF motif RNAs remains unknown, our findings suggest that this riboswitch class might serve as part of a genetic response system to toxic or signaling compounds with chemical structures similar to azaaromatics.
Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?
Authors: Ortuno Daniel , Carlisle Holly J. , Miller Silke
Published: February 2016

A common pathological hallmark of age-related neurodegenerative diseases is the intracellular accumulation of protein aggregates such as α-synuclein in Parkinson’s disease, TDP-43 in ALS, and tau in Alzheimer’s disease. Enhancing intracellular clearance of aggregation-prone proteins is a plausible strategy for slowing progression of neurodegenerative diseases and there is great interest in identifying molecular targets that control protein turnover. One of the main routes for protein degradation is through the proteasome, a multisubunit protease that degrades proteins that have been tagged with a polyubiquitin chain by ubiquitin activating and conjugating enzymes. Published data from cellular models indicate that Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), slows the degradation of tau and TDP-43 by the proteasome and that an inhibitor of USP14 increases the degradation of these substrates. We conducted similar experiments designed to evaluate tau, TDP-43, or α-synuclein levels in cells after overexpressing USP14 or knocking down endogenous expression by siRNA.
The power of shared philosophy: A study of midwives' perceptions of alternative birth care in Norway
Authors: Helberget Lindis , Fylkesnes Anne-Margrethe , Crawford Paul , Svindseth Marit
Published: February 2016

Aims:

The aim of this study was to explore important factors that promote the best possible health for mother and child during pregnancy, birth and post-birth in an alternative birth clinic (ABC) in Norway.

Design:

The authors used in-depth interviews to identify factors important in ABCs according to the holistic treatment model in the philosophy of ABCs.

Methods:

Transcription and text condensation were achieved by looking for text to find themes and subthemes to explore daily activities and the role of empowerment.

Results:

The most important factors were teaching women how to cope, mentally and practically, and being true to the philosophy of ABCs. Factors connected to empowerment of the women were strengthening their ability to make good decisions, their ability to cope practically, and the midwives' ability to step back and let the women gradually take responsibility.

Conclusions:

The ABC in this study reflected theoretical principles for ABCs. Midwives shared common opinions of important factors empowering women.
Tell it Right, Start it Right: An evaluation of training for health professionals about Down syndrome
Authors: Bryant Louise D , Puri Sheila C , Dix Lucy , Ahmed Shenaz
Published: February 2016

Midwives do not routinely receive training in how to manage parent care when Down syndrome (DS) is identified in pregnancy or after birth. Many parents report dissatisfaction with the response of health professionals during this time. In response to this, the UK Down's Syndrome Association has developed the Tell it Right, Start it Right training. This paper reports on an evaluation of the training using the Kirkpatrick model ( Kirkpatrick and Kirkpatrick, 2006 ). A repeated measures online survey was delivered before training, immediately after training and 2 months after training. Midwives constituted the majority of participants. The evaluation found that knowledge of DS, confidence in communicating with parents and confidence in delivering a diagnosis of DS significantly increased after attending. Some evidence of applying knowledge in the workplace was identified; however, such training must become embedded in mandatory professional education if widespread improvements in parent experience are to be achieved.
Exploring undisturbed birth through art and social media: An interactive project with student midwives
Authors: Uppal Elaine , Davies Sarah , Nuttall Janet , Knowles Helen
Published: February 2016

Aim:

To facilitate exposure of student midwives to images of undisturbed birth by engagement with the YouTube Series of images created by artist Helen Knowles (2015) .

Background:

Although birth in the Western world is a relatively safe process, there is a culture of fear around the process of giving birth. Women search for ‘realistic’ accounts from other women, as indicated by the number of hits on the YouTube videos on which Knowles’ YouTube Series is based.

Methods:

As part of their midwifery education, midwifery students from a range of groups were shown the YouTube Series screen-print images. The associated videos were then played to the students, followed by a class discussion.

Findings:

Themes that arose from the discussions included tensions around using social media in the curriculum, and the educational value of viewing undisturbed birth.

Conclusions:

It is important for midwifery educationalists to engage with technology and social media to be able to appreciate women's and students’ perspectives. It is also necessary to be aware of potential difficulties inherent in the use of social media, such as in relation to professional behaviour, the possible exploitation of women and ownership of the material. The study raised important issues for further investigation and analysis, and suggests that the videos and artwork have significant potential as tools for learning.
‘Make a Noise about Bullying’: Empowering pupils to speak out
Authors: Feuchtwang Anna
Published: February 2016

Is your school a ‘talking school’, where students are empowered to speak out about bullying, wherever they see it? Anna Feuchtwang explains.
Need parasite advice and information? Turn to ESCCAP!
Authors: Stokes Laura
Published: February 2016

For free resources and scientifically robust and trustworthy information, there's a one-stop shop… ESCCAP (European Scientific Counsel for Companion Animal Parasites).
Introduction to shelter medicine: a new way of thinking
Authors: Stavisky Jenny , Dean Rachel
Published: February 2016

Shelter medicine involves safeguarding the physical and psychological health, and the welfare, of populations of animals sheltered in rescue organisations. It is an increasing area of work for small animal practitioners, and requires a different skill set to dealing with privately owned individual patients. Like all aspects of practice it can be hugely challenging yet hugely rewarding. This is the first in a series of articles that will explore some of the challenges of shelter medicine in the UK.
Clearing the Minefield: State Theory and Geopolitical Economy
Authors: Jonathan Pratschke
Published: February 2016

Four recent books on competition and crisis in the 20th century have contributed to renewed interest in Marxist theory while reopening some contentious issues. While central to all four books, the role of the capitalist state is not theorised systematically, a weakness which reflects an enduring gap in Marxist theory. One of the challenges when theorising the state is that the latter must be situated within a complex set of multiscalar relationships involving accumulation and competition. The author argues that the state must be understood as having multiple, intersecting determinations and suggests that a satisfactory theory of the state may be constructed by showing how these determinations arise from the logic of capitalist competition and crisis. Conceptualised as generative mechanisms, they denote not only the main influences on state decisions and behaviour but also—and crucially—the fundamental limits on state decision making.
Geopolitical Economy and Competing Capitalist Blocs in the EU Post-Crisis Financial Regulation: Two Cases from the Reform of the Banking Sector
Authors: Giuseppe Montalbano
Published: February 2016

In this contribution I will test the geopolitical-economic approach as formulated by Desai (2013) in the analysis of the EU's regulatory response to the financial crisis by focusing on two relevant pieces of legislation in the post-crisis reform of banking governance: the adaptation of the Basel III agreement to the package on Capital requirements, composed of a regulation and a directive, and the ongoing legislative process concerning the structural reform of banks. As I try to show, the concept of “competing geopolitical bloc” derived from the work of Desai, but even detectable in some recent Neo-Gramscian literature, is useful in analysing the shortcomings of the European regulatory response to the 2007/8 economic and financial crisis.
Listening to the Monster: Eliding and restoring the creature’s voice in adaptations of Frankenstein
Authors: Wright Jude
Published: February 2016

This article examines the integral subject of the Monster’s speech in reference to stage and film adaptations by Richard Brinsley Peake, James Whale and Nick Dear. The focus of the article is the Monster’s vocality and ability to communicate, a complicated subject from the earliest of the novel’s adaptations. It examines the history of the Monster’s speech as well as the way in which that speech or silence interacts with the layers of adaptation each new version is engaged with. In this way it demonstrates how integral vocality is to a sympathetic vision of the Monster, even when it is no longer present in the adaptation. To utilize Marvin Carlson’s critical idiom, even our visions of the silent Monster are ghosted by the vocality of Shelley’s original creation. Nick Dear’s recent stage adaptation seeks to intervene in this trajectory and restore the Creature’s narrative, giving him both voice and authority over his own experiences.
Ezagutzaren dinamika Ikas Komunitateetan
Authors: Pastor Andrés David , Bereziartua Zendoia Justo
Published: February 2016

Las experiencias que se han venido desarrollando en las Comunidades de Aprendizaje de la Comunidad Autónoma Vasca ofrecen una buena muestra de las diversas prácticas que promueven la cooperación e impulsan el aprendizaje. A través de este análisis cualitativo se describe, desde el paradigma de las comunidades de prácticas de las organizaciones, la dinámica de conocimiento de las Comunidades de Aprendizaje. En el análisis se han interpretado los procesos de construcción del conocimiento, partiendo para ello de la observación de sucesos y acciones cotidianas en los centros educativos. Los resultados se distribuyen en dos ámbitos: en primer lugar, las redes de comunicación y los contenidos de aprendizaje y, en segundo lugar, los movimientos de transformación del conocimiento y de los procesos individuales a colectivos.
HUHEZIko hiru gradu presentzialen lehenengo mailako ikasleen moodle plataformaren erabileraren azterketa
Authors: Arriaran Olalde Iñigo
Published: February 2016

En la actualidad las plataformas online tienen un papel muy importante en la educación y se están utilizando en la mayoría de las universidades. En los tres grados que se imparten en modalidad presencial, en la facultad de Humanidades y Ciencias de la Educación (HUHEZI) de Mondragon Unibertsitatea, se utiliza la plataforma Moodle desde el curso 2009-2010. Hasta ahora no se ha hecho ninguna evaluación acerca de la utilización de la plataforma en esos tres grados. Este trabajo de investigación quiere analizar ciertos aspectos de dicha utilización, en concreto se quiere responder a estas preguntas: La secuencia didáctica que se define en el diseño de la asignatura en Moodle, ayuda a entender mejor la organización de la asignatura? Los alumnos conocen la herramienta Foro de la plataforma? La utilizan? Cuál es el nivel de conocimiento y uso de la plataforma por parte de los tutores? A tenor de los resultados obtenidos, la secuencia didáctica de la asignatura definida en la plataforma ayuda en la mayoría de las veces a entender mejor la organización de la asignatura, los alumnos, en una amplia mayoría no conocen ni usan la herramienta Foro de la plataforma y aunque la mayoría de los alumnos creen que el nivel de conocimiento de la plataforma por parte de los tutores es alto, también creen que no se utilizan muchas herramientas disponibles en Moodle.
Colaboração entre Professores e Perceções da Eficácia da Escola e da Dificuldade do Trabalho Docente
Authors: Lima Jorge Ávila de , Fialho Adolfo
Published: February 2016

A colaboração entre docentes é considerada por muitos autores como um poderoso fator de aprendizagem profissional dos professores e de eficácia das escolas. No presente trabalho, procura‑se perceber se os níveis mais intensos de interação profissional entre colegas estão associados a maiores perceções de eficácia da escola e a menores sentimentos de dificuldade do trabalho.O estudo empírico foi realizado em três escolas do 1.º Ciclo do Ensino Básico. Os dados foram recolhidos através de um inquérito por questionário e analisados com recurso à estatística descritiva e inferencial e à análise de redes sociais. Os resultados mostram que é possível retirar diferentes conclusões sobre a matéria, consoante a análise tome como unidade de observação a escola ou o docente.Os resultados obtidos ao nível individual mostram que o envolvimento colaborativo dos docentes não apresentou associação significativa com as perceções sobre a eficácia da escola, mas mostrou uma associação clara e de sentido negativo com as perceções de dificuldade do trabalho docente.
Avaliação das Expetativas e das Vivências Académicas na Transição para o Ensino Superior
Authors: Belo Pedro
Published: February 2016

Este estudo pretende contribuir para a compreensão de alguns aspetos psicológicos que envolvem uma situação de transição para o ensino superior. Utilizou‑se um questionário de expetativas académicas (Questionário de Envolvimento Académico ‑ versão expetativas) e um outro de vivências académicas (Questionário de Vivências Académicas – versão reduzida) como instrumentos de recolha de dados, junto de uma amostra de 1121 alunos dos 1.º e 2.º anos da Universidade de Coimbra. Desta, retirámos uma subamostra – designada por “potenciais abandonantes” – composta por 117 alunos que haviam reprovado, pelo menos, um ano. Estes alunos apresentam resultados nas subdimensões das Vivências Académicas de Estudo e Carreira mais baixos do que os estudantes que nunca reprovaram. Os seus resultados nas subescalas de EnvolvimentoInstitucional, Vocacional e Curricular são também comparativamente mais baixos (p < .05) do que os dos outros alunos. Os dados obtidos indicam que as instituições devem ter em conta as expetativas e as vivências académicas na prevenção do abandono escolar.
Anonimi irrimediabili nel Cancioneiro da Ajuda: Sennor fremosa, pois me vej’aqui (A277)
Authors: Barberini Fabio
Published: February 2016

Edizione critica e commento della cantiga A277, Sennor fremosa, pois me vej’aqui. La cantiga è tràdita, priva di attribuzione, dal solo Cancioneiro da Ajuda e il confronto con i più completi canzonieri galego-portoghesi di Colocci (B e V) non permette di identificare con sicurezza l’autore del testo. Sebbene António Resende de Oliveira abbia proposto di attribuire A277 a Afons’Eanes do Coton, i risultati dell’analisi stilistica effettuata nella seconda parte dell’articolo non confermano l’ipotesi dello studioso portoghese.
Corella amb harmonies del segle XX: la cantata Vida de Maria d’Amand Blanquer (1935-2005)
Authors: Ferrando Morales Àngel Lluís
Published: February 2016

Els textos literaris representen una part important del material del qual fa ús el compositor alcoià Amando Blanquer Ponsoda (1935-2005) en moltes de les seues composicions. Al llarg del seu catàleg, extens i ben variat, trobem una nòmina notable i heterogènia d’autors els quals, mitjançant les seues creacions literàries, actuen com a font d’inspiració per a la música de Blanquer. De tot aquest conjunt, destaquen els textos medievals hispànics, que tenen en les obres de Juan de Mena, Ausiàs March, Joanot Martorell i Joan Roís de Corella, la seua plasmació. L’estudi de la cantata Vida de Maria (1979-1981), una composició de llarga gestació sobre un text de Corella, és l’objectiu d’aquest paper. L’anàlisi de l’obra i el seu acarament amb el text al qual deu la seua articulació, tracta d’esbrinar les relacions amb la poesia de Corella i la proposta sonora de Blanquer, empresa ben atractiva sempre pel tarannà humanístic en general, i literari en particular, d’aquest compositor.
La expresión del joi en la escuela trovadoresca gallegoportuguesa
Authors: Fidalgo Elvira
Published: February 2016

Si la poesía trovadoresca occitana viene definida por el joi como manifestación de un amor correspondido o, al menos, esperanzado, la poesía de los trovadores gallegoportugueses viene, al contrario, caracterizada por la expresión del dolor de saber que nunca serán amados y que en el plano léxico se define con el término coita. No obstante, hacia el último cuarto del s. xiii, algunos trovadores rompen con esta característica esencial a la cantiga de amor y en algunas composiciones expresan su alegría obtenida por diversas razones: amor esperanzado, amor correspondido o la simple posibilidad de ver a la amada. En este trabajo se analizarán los escasísimos textos en los que se manifiesta esa voluntad de distanciarse del conglomerado homogéneo de trovadores, con el deseo de ampliar el reducido abanico de temas y motivos que forjaron el modelo en los albores de la escuela, a través de un juego literario en el que estos pocos autores parecen haber continuado la estela del primero que se atrevió a transgredir las directrices asentadas por la tradición. Como es prácticamente imposible ordenar cronológicamente las cantigas que vamos a presentar, optaré por un criterio de mayor a menor reconocimiento de la expresión del contento amoroso, combinado con el cronológico (en la medida de lo posible).
Comic - Film - Gender
Authors: Sina Véronique
Published: February 2016

Welche Rolle spielt die Kategorie Gender für die Konstitution von Comic und Film? Véronique Sina geht dieser Frage anhand ausgewählter Comic- und Filmbeispiele wie Frank Millers »Sin City«, Enki Bilals »Immortel (ad vitam)« oder Matthew Vaughns »Kick-Ass« nach. Auf Basis einer detailreichen, vergleichenden Analyse beider Medien entwickelt sie das Konzept des performativen Comicfilms und verdeutlicht dabei gleichzeitig, wie sich Comic, Film und Gender wechselseitig generieren und produktiv aufeinander einwirken. Mit dieser Fokussierung auf die reziproke Beziehung der Performativität von Gender sowie der Medialität des Performativen leistet die Studie einen wichtigen Beitrag zu den Gender-Media Studies.
»Welcome to My Bunker« - Vietnamkriegserfahrung im Internet
Authors: Leikauf Roland
Published: February 2016

»Willkommen zurück!« - Auf tausenden Websites begrüßen Vietnamveteranen die Besucher in ihrer neuen Heimat: dem Internet. Das Netz hat für viele Beteiligte des längsten und umstrittensten Kriegs, den Amerika je geführt hat, eine wichtige Bedeutung gewonnen. Der Historiker Roland Leikauf zeigt: Hier findet nicht weniger als die radikale Redefinition der Konzepte »Vietnamveteran« und »Vietnamkrieg« statt. Die Studie lässt deutlich werden, warum die Kriegsverarbeitung im virtuellen »Raum« auch für die Veteranen aktueller Kriege immer wichtiger wird.
The Night I Became a Jazz Musician
Authors: Kirchner Bill
Published: February 2016

Bill Kirchner recalls a formative episode his life at the 1965 Pittsburgh Jazz Festival.
Estudio de los imaginarios sociales urbanos desde las prácticas pedagógicas.
Authors: Aguilera-Martínez Fabián Adolfo , Vargas-Niño Paula Alejandra , Serrano-Cruz Natalia Isabel , Castellanos-Escobar María Camila
Published: February 2016

El imaginario social es un encuentro de la memoria con la conciencia, una raíz de significados que, por las pérdidas de herencia, olvidamos. El artículo busca mostrar cómo los imaginarios que tienen los estudiantes acerca de su ciudad, se pueden construir desde el aprendizaje a través de la experiencia. El "diseño participativo" es el instrumento en el cual el estudiante, a partir de los grupos de práctica en investigación como formación - "imaginarios sociales y representaciones", construye su imaginario siempre desde lo transdisciplinar; es un encuentro donde los discursos construyen los escenarios pertinentes para actuar a través de las "acciones urbanas"; sin duda, es darle significado a la memoria, pues, de acuerdo con Castoriadis, la creación imaginaria es una consecuencia que nace del ámbito social-histórico que desde la creación de formas culturales se ha convertido para los estudiantes del semillero en "acciones de memoria".
Barrios Altos: caracterización de un conjunto de barrios tradicionales en el marco del Centro Histórico de Lima
Authors: Shimabukuro Angie
Published: February 2016

Desde 1991, una significativa parte del Centro Histórico de Lima (CHL) está incluida en el área inscrita en la lista de Patrimonio Cultural de la Humanidad, de la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (Unesco). Barrios Altos es un sector urbano tradicional que hace parte del CHL, y que sobresale debido a la notable riqueza que representa su patrimonio cultural, material e inmaterial, pero también por su condición de sector pobre y marginado, y deteriorado en sus condiciones de habitabilidad. A partir de la búsqueda y recolección de información en Francia, España y Perú, este artículo tiene por objetivo exponer la situación histórica de Barrios Altos, su proceso de patrimonialización —contexto nacional y de la humanidad— y los hallazgos preliminares sobre la recuperación del CHL a través de las campañas de concientización y de las intervenciones municipales en los espacios públicos de dicho sector, entre los cuales sobresalen dos casos emblemáticos: el Mercado Central y el Barrio Chino.
«El Dorado» à la Française ou à l’Allemande? une étude comparée des cinémas de Strasbourg.
Authors: Hosseinabadi Shahram
Published: February 2016

La présente contribution tente d’étudier les cinémas de Strasbourg réalisés dans première moitié du XXe siècle selon l’approche des études de transferts culturels afin de mettre en évidence leurs aspects métissés. Pour ce faire, dans une étude comparée avec les expériences parisiennes et berlinoises, sont d’abord analysées des salles édifiées avant la Grande Guerre – période où Strasbourg était allemande – puis quelques réalisations de l’entre-deux-guerres – où l’Alsace est redevenue française. L’architecture cinématographique strasbourgeoise n’a été abordée, jusqu’à ce jour, que sommairement et de manière isolée dans quelques travaux universitaires. Cette étude croisée permet de dépasser la périodisation classique de l’histoire architecturale alsacienne suivant les changements de souveraineté de cette région frontalière. Elle révèle également l’intérêt des cinémas comme un type d’édifice propice aux transferts de modèle et aux métissages architecturaux, de même que la nécessité d’étendre ce type d’analyse à l’échelle transcontinentale.
Evangelización y precariedad : la arquitectura religiosa sin corporaciones ni academias en la nueva Granada.
Authors: Arango-Liévano Lucia
Published: February 2016

En el presente artículo se aborda la arquitectura religiosa desde la perspectiva de una historia cultural, con el objetivo hacer un aporte metodológico al estudio de los procesos que permitieron la constitución de una arquitectura religiosa en la Nueva Granada (Colombia actual), territorio en el cual no existían circuitos oficiales de producción artística. Tomando distancia de una historiografía basada en el análisis de la forma y su clasificación taxonómica, se privilegia la investigación documental como principal herramienta metodológica. La lectura culturalista de los documentos que dan cuenta de la construcción de la iglesia de Pacho (Cundinamarca) contribuye a la comprensión de la estructura de los sistemas productivos en el territorio granadino. En el texto se reconocen algunos de los principales oficios implicados en la construcción (cantero, albañil, carpintero) y se da cuenta de los rangos jerárquicos dentro de cada oficio, los cuales permitieron la circulación de ideas y de conocimientos.
East Central Europe: the gate to Byzantium
Authors: Curta Florin
Published: February 2016

Medieval East Central Europe is currently defined as the territory between the Holy Roman-German Empire and Byzantium. Little attention has been paid to how the region mediated between Byzantium and the rest of Europe. From relics to texts, and from coins and pottery to helmets, the countries in East Central Europe - Hungary, Poland, and Bohemia - have not let all things Byzantine move farther afield. What and when Byzantine things were allowed to pass has been a matter of political circumstances. Particularly significant in this respect was the crusading period, during which Hungary came to be regarded as the gate to Byzantium. East Central Europe was perceived as an alternative, not as a part of the Byzantine Commonwealth. That may explain the weak interest in things Byzantine among the scholars in the region, with the notable exception of the Hungarian historians.
The Church of St. Catherine in Thessalonike: its topographical setting and the current state of scholarship
Authors: Hadjitryphonos Evangelia
Published: February 2016

The Church of St. Catherine representing one of the outstanding achievements of Byzantine architecture in Thessaloniki, and vital to our understanding of late Byzantine church building, has not been sufficiently studied. The intention of this study is to present a number of issues - taking into consideration that the information about this church is dispersed in many studies about different topics of Byzantine culture and archaeology - and to focus on its topographical setting, its immediate environs, the available sources, and the current state of scholarship, as well to present new information such as the document of dedication on occasion of its conversion into a mosque. - The main conclusions to be drawn are the following: Limited information about the church and its area; its identification mostly with churches dedicated to Christ; its dedication to St. Catherine mentioned for the first time in the Ottoman period; conflicting proposals to dating the monument between the twelfth and the second half of the fourteenth century; consideration of two opinions, first holding the church design and its implementation according to a unified plan, and a second based on different phases requiring further examination.
Nature and deliberation in Bessarion’s De natura et arte
Authors: Marchetto Monica
Published: February 2016

The present contribution will concentrate on the central issue discussed by Bessarion in one of his major works, the De natura et arte (written in 1458 and published in 1469 as the sixth book of Bessarion’s In calumniatorem Platonis), i. e. the concept of deliberation and the relationship between nature, purposiveness and deliberation. In De natura et arte Bessarion responds to an attack by George of Trebizond, who had demonstrated, against Bessarion, not only that nature does not deliberate, but also that deliberation cannot be attributed to God who guides nature either, since deliberation implies doubt and ignorance. In this contribution I will examine the strategies Bessarion uses in order to reaffirm the possibility of attributing deliberation even to God and the arguments through which he succeeds in stressing the fundamental agreement on this subject not only between Plato and Aristotle, but also and more importantly between Plato and Christian theology.
Catalytic synthesis of 2-methyl-1,4- naphthoquinone in 1%Au/HPS presence
Authors: Shimanskaya Elena I. , Sulman Esther M. , Doluda Valentin Yu.
Published: February 2016

In this paper, theoxidation process of
2 -methylnaphthalene to vitamin K3, using a gold catalyst
systems will be discussed. This catalysis process is based
on the hypercrosslinked polystyrene, synthesized by the
impregnation with solutions of precursors − HAuCl4·2H2O
and Ph3PAuCl. The use of gold catalyst system, which has
been synthesized using Ph3PAuCl, allows to obtain the
main product − 2-methyl-1,4-naphthoquinone − with 72%
yield.
Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton
Authors: Nüße Jessica , Mirastschijski Ursula , Waespy Mario , Oetjen Janina , Brandes Nadine , Rebello Osmond , Paroni Federico , Kelm Sørge , Dietz Frank
Published: February 2016

Hepatoma-derived growth factor (HDGF) is involved in diverse, apparently unrelated processes, such as cell proliferation, apoptosis, DNA-repair, transcriptional control, ribosome biogenesis and cell migration. Most of the interactions of HDGF with diverse molecules has been assigned to the hath region of HDGF. In this study we describe two previously unknown HDGF isoforms, HDGF-B and HDGF-C, generated via alternative splicing with structurally unrelated N-terminal regions of their hath region, which is clearly different from the well described isoform, HDGF-A. In silico modeling revealed striking differences near the PHWP motif, an essential part of the binding site for glycosaminoglycans and DNA/RNA. This observation prompted the hypothesis that these isoforms would have distinct interaction patterns with correspondingly diverse roles on cellular processes. Indeed, we discovered specific associations of HDGF-B and HDGF-C with cytoskeleton elements, such as tubulin and dynein, suggesting previously unknown functions of HDGF in retrograde transport, site directed localization and/or cytoskeleton organization. In contrast, the main isoform HDGF-A does not interact directly with the cytoskeleton, but via RNA with messenger ribonucleoprotein (mRNP) complexes. In summary, the discovery of HDGF splice variants with their discrete binding activities and subcellular distributions opened new avenues for understanding its biological function and importance.
Grey Wolf Algorithm-Based Clustering Technique
Authors: Kumar Vijay , Chhabra Jitender Kumar , Kumar Dinesh
Published: February 2016

The main problem of classical clustering technique is that it is easily trapped in the local optima. An attempt has been made to solve this problem by proposing the grey wolf algorithm (GWA)-based clustering technique, called GWA clustering (GWAC), through this paper. The search capability of GWA is used to search the optimal cluster centers in the given feature space. The agent representation is used to encode the centers of clusters. The proposed GWAC technique is tested on both artificial and real-life data sets and compared to six well-known metaheuristic-based clustering techniques. The computational results are encouraging and demonstrate that GWAC provides better values in terms of precision, recall, G-measure, and intracluster distances. GWAC is further applied for gene expression data set and its performance is compared to other techniques. Experimental results reveal the efficiency of the GWAC over other techniques.
Hydrodynamics with Spin Angular Momentum from Systematic Coarse Graining: A Tutorial Example
Authors: Ilg Patrick
Published: February 2016

The derivation of time evolution equations for slow collective variables starting from a microscopic model system is demonstrated for the tutorial example of the classical, two-dimensional XY model. Projection operator techniques are used within a nonequilibrium thermodynamics framework together with molecular simulations in order to establish the building blocks of the hydrodynamics equations: Poisson brackets that determine the deterministic drift, the driving forces from the macroscopic free energy and the friction matrix. The approach is rather general and can be applied for deriving the equations of slow variables for a broad variety of systems.
Oral propranolol in early stages of retinopathy of prematurity
Authors: Bancalari Aldo , Schade Ricardo , Muñoz Tomás , Lazcano Carolina , Parada Rodrigo , Peña Rubén
Published: February 2016

To assess the effect of oral propranolol on the progression of early stages of retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants.

We analyzed VLBW infants with ROP (stages 2–3, zones II-III). Newborns received oral propranolol (0.5 mg/kg/dose q8h), and were monitored throughout the treatment period for possible side effects. Propranolol was administered until regression of ROP. A historic control group of patients with equivalent ROP was used. We compared characteristics of both groups and the progression of retinopathy.

Forty-seven newborns were included, 20 in the propranolol group and 27 in the control group. There were no significant differences in gestational age, birthweight or gender. The mean duration of treatment with propranolol was 58.2±17.6 days. Most patients started treatment with stage 2 disease (65.0%), and had zone III involvement (55.0%). In the treated group, 90.0% (18/20) of patients did not require intervention with laser or bevacizumab, compared to 51.8% in the control group (P<0.005). No cases of bradycardia, hypotension or hypoglycemia were observed.

Oral propranolol in early stages of ROP could prevent disease progression and reduce the need for invasive rescue therapy with laser or bevacizumab. No significant side effects were reported.
Crystal structure of rac-4,4,4-trifluoro-3-hydroxy-3-methylbutanoic acid, C5H7O2F3
Authors: Sephton Bereneice , Sephton Abigail , Hickson Matthew , Dugmore Travis , Betz Richard
Published: February 2016

C5H7O3F3, monoclinic, P21/c, a = 7.9450(4) Å, b = 21.0079(10) Å, c = 8.5285(3), β = 101.240(2)°, V = 1396.17(11) Å3, Z = 8, R
gt(F) = 0.0374, wR
ref(F
2) = 0.1005, T = 200.
Crystal structure of trans-1,2-bis(pyridinium-4-yl)ethylene–2-carboxy-4-methylbenzoate (1/2), C30H26N2O8
Authors: Jing Liu , Min-Le Han
Published: February 2016

C30H26N2O8, monoclinic, C2/c (no. 15), a = 17.567(2) Å, b = 13.1375(17) Å, c = 13.4212(17) Å, β = 124.08(1)°, V = 2565.3(6) Å3, Z = 4, R
gt
(F) = 0.0379, wR
ref
(F
2
) = 0.0839, T = 296 K.
Implementation of a multicomponent Responsible Beverage Service programme in Sweden-a qualitative study of promoting and hindering factors
Authors: Haggård Ulrika , Trolldal Björn , Kvillemo Pia , Guldbrandsson Karin
Published: February 2016

Aims

The objective of this study was to identify factors that either promote or hinder implementation of a multicomponent Responsible Beverage Service programme in Swedish municipalities.

Design

Forty semi-structured interviews were conducted in six municipalities and directed content analysis, guided by the Consolidated Framework for Implementation Research (CFIR), was performed.

Results

The CFIR framework was useful as an underlying theoretical model in this study. Importance of the following factors, described in the five domains of CFIR, was empirically supported in this study: local needs, evidence strength and advantages of the intervention, costs and available resources, clear goals, evaluation and feedback, access to knowledge and information, clear role definitions and cooperation, and enthusiastic key persons with high confidence in the effectiveness of the intervention. Hindering factors listed by the informants were lack of enthusiasm and opportunities to specialise, low degree of self-efficacy, unengaged decision-makers, complexities of the programme, and a top-down approach.

Conclusions

This study indicates that previously identified factors shown to promote and hinder implementation processes are also valid in the context of multicomponent community action programmes like RBS. Suggestions on how to elude some of the hindering factors are proposed, e.g. to develop long-time financial plans, to provide better information about the RBS program in full, and to stress the importance of collaboration between representatives from the municipalities, police authorities and owners of on-licenced premises.
Religious Healing and the Asclepius Cult:
A Case of Placebo Effects
Authors: Panagiotidou Olympia
Published: February 2016

This paper suggests a cognitive approach to the Asclepius cult which may throw light on the
supplicants’ personal experiences of healing during the ritual of incubation. In particular, the possibility
of healing at the Asclepius sanctuaries is presented as a potential result of the patients’ placebo responses.
The prerequisites of placebo effect as determined by Nicholas Humphrey are traced in the wider social
and conceptual contexts of Greek antiquity and the specific religious context of the Asclepius cult. In this
framework, it is argued that personal experiences of people, social information about the Asclepius’ healing
powers and the confirmation of this information by human doctors would have influenced how people
“lived” an illness or a disease infliction, “appropriated” the religious beliefs in Asclepius, and experienced
cures at the asclepieia. These cures could have derived from patients’ self-healing mechanisms, but would
have been perceived and conceptualized as “healing miracles” performed by the god. This preliminary
study intends to show how cognitive approaches can enrich historical knowledge on the Asclepius cult
and on supplicants’ healing experiences, suggesting that such approaches may contribute to a better
understanding of “lived religion” and of multiple religious experiences in various religious contexts.