bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms
Authors: Ott German , Kalmbach Sabrina , Grau Michael , Zapukhlyak Myroslav , Leich Ellen , Jurinovic Vindi , Hoster Eva , Staiger Annette , Kurz Katrin , Weigert Oliver , Gaitzsch Erik , Passerini Verena , Engelhard Marianne , Herfarth Klaus , Beiske Klaus , Micci Francesca , Möller Peter , Bernd Heinz-Wolfram , Feller Alfred , Klapper Wolfram , Stein Harald , Hansmann Martin-Leo , Hartmann Sylvia , Dreyling Martin , Holte Harald , Lenz Georg , Rosenwald Andreas , Ott German , Horn Heike
Published: June 2023

Knowledge on the pathogenesis of FL is mainly based on data derived from advanced/systemic stages of FL (sFL) and only small cohorts of localized FL (lFL) have been characterized intensively so far.
Comprehensive analysis with profiling of somatic copy number alterations (SCNA) and whole exome sequencing (WES) was performed in 147 lFL and 122 sFL. Putative targets were analyzed for gene and protein expression.
Overall, lFL and sFL, as well as BCL2translocation-positive (BCL2+) and –negative (BCL2-) FL showed overlapping features in SCNA and mutational profiles. Significant differences between lFL and sFL, however, were detected for SCNA frequencies, e.g. in 18q-gains (14% lFL vs. 36% sFL; p=0.0003). Although rare in lFL, gains in 18q21 were associated with inferior progression-free survival (PFS). The mutational landscape of lFL and sFL included typical genetic lesions. However, ARID1A mutations were significantly more often detected in sFL (29%) compared to lFL (6%, p=0.0001). In BCL2+ FL mutations in KMT2D, BCL2, ABL2, IGLL5 and ARID1A were enriched, while STAT6mutations more frequently occurred in BCL2- FL. Although the landscape of lFL and sFL showed overlapping features, molecular profiling revealed novel insights and identified gains in 18q21 as prognostic marker in lFL.
The impact of phage treatment on bacterial community structure is negligible compared to antibiotics
Authors: Gundersen Madeleine S. , Fiedler Alexander W. , Bakke Ingrid , Vadstein Olav
Published: June 2023

Background
Phage treatment is suggested as an alternative to antibiotics; however, there is limited knowledge of how phage treatment impacts resident bacterial community characteristics. When phages induce bacterial lysis, resources become available to the resident community. Therefore, the density of the target bacteria is essential to consider when investigating the effect of phage treatment but has never been studied. Thus, we invaded microcosms containing a lake-derived community with Flavobacterium columnare strain Fc7 at no, low or high densities and treated them with either the bacteriophage FCL-2, the antibiotic Penicillin or kept them untreated (3x3 factorial design). The communities were sampled over the course of one week, and bacterial community composition and density were examined by 16S rDNA amplicon sequencing and flow cytometry.
Results
We show that phage treatment had negligible impacts on the resident community when the phage host F. columnare Fc7 was present, as it caused insignificant differences in bacterial density, α- and β-diversity, successional patterns, and community assembly. However, a significant change was observed in community composition when the phage host was absent, mainly driven by a substantial increase in Aquirufa. In contrast, antibiotics induced significant changes in all community characteristics investigated. The most crucial finding was a bloom of γ-proteobacteria and a shift from selection to ecological drift dominating community assembly.
Conclusions
This study investigated how phage host density impacts phage treatment effects and provides strong evidence that bacteriophages do not significantly affect the composition of bacterial communities. The findings highlight the importance of considering the density of target bacteria when investigating the effect of phage treatment, as more changes were observed when the phage host was absent. Moreover, higher phage host densities increased the contribution of stochastic community assembly and resulted in a feast-famine like response in bacterial density. This finding emphasises that the invader density used in bacterial invasion studies impacts the experimental reproducibility. Overall, this study supports that phage treatment is substantially less disturbing to bacterial communities than antibiotic treatments.
Exploring the Structural and Electronic Characteristics of Phenethylamine Derivatives: A Density Functional Theory approach
Authors: B Arya , P Sachidanandan , S Jayasudha , M Deepa , M Anandakumar V
Published: June 2023

Accurate structure elucidation of biologically active molecules is crucial for designing and developing new drugs, as well as for analyzing their pharmacological activity. In this study, density functional theory calculations are applied to explore the electronic structure and properties of phenethylamine derivatives, including Amphetamine, Methamphetamine, and Methylene Dioxy Methamphetamine(MDMA). The investigation encompasses various aspects such as geometry optimization, vibrational analysis, electronic properties, Molecular Electrostatic Potential analysis, and local and global descriptor analysis. Additionally, the study utilizes Natural Bond Orbital analysis and Quantum Theory of Atoms in Molecules to investigate the chemical bonding and charge density distributions of these compounds. Experimental techniques such as Fourier transform infrared (FT-IR) and Raman spectroscopic analysis are employed in the range of 4000-400 cm-1 and 4000-50 cm-1, respectively. Theoretical vibrational analysis with Potential Energy Distribution(PED) assignments is conducted, and the resulting frequencies are compared to experimental spectral data, revealing good agreement. By correlating various structural parameters with the pharmacological activity of each derivative, computational structure elucidation aids in understanding the unique actions of phenethylamine derivatives. The obtained results offer a comprehensive understanding of the molecular behavior and properties of these drugs, facilitating the development of new drugs and therapies for addiction and related disorders.
Turning alterations detected by mobile health technology in idiopathic REM sleep behavior disorder
Authors: pilotto Andrea , Zatti Cinzia , Hansen Clint , Rizzardi Andrea , Catania Marcello , Romijnders Robbin , Purin Leandro , Pasolini Maria , schaeffer eva , Galbiati Andrea , Ferini-Strambi Luigi , Berg Daniela , Maetzler Walter , Padovani Alessandro
Published: June 2023

Introduction: Idiopathic REM sleep Behavior Disorder (iRBD) is a condition at high risk of developing Parkinson’s disease (PD) and other alpha-synucleinopathies. Aim of the study was to evaluate subtle turning alterations by using Mobile health technology (MHT) in iRBD individuals without subthreshold parkinsonism.Methods A total of 148 participants (23 persons with polysomnography-confirmed iRBD without subthreshold parkinsonism, 60 drug-naïve PD patients and 65 age-matched controls (HC)) were included in this prospective cross-sectional study. All underwent a multidimensional assessment including cognitive and non-motor symptoms assessment. Then a Timed-Up-and-Go test (TUG) at normal and fast speed was performed using MHT (Rehagait®, Hasomed, Germany). Durations, mean and peak angular velocities of the turns were compared using a multivariate model correcting for age and sex.Results Compared to HC, PD patients showed longer turn durations and lower mean and peak angular velocities of the turns in both TUGs (all p ≤ 0.001). iRBD participants showed also a longer turn duration and lower mean (p = 0.006) and peak angular velocities (p < 0.001) compared to HC, but only in the TUG at normal speed.Conclusion MHT assessment identified subtle alterations of turning at normal speed in iRBD patients. The lack of difference between iRBD patients and HC at fast speed may indicate the presence of (unconscious) compensation mechanisms that are activated during challenging mobility conditions. Longitudinal studies are warranted to evaluate the value of objective turning parameters in defining the risk of conversion to PD in iRBD and in tracking motor progression in prodromal PD.
Evaluating BMWM scenario of Alwar through KAP index of the hospital staff
Authors: Bhambhani Deepa , Sharma Sunder Lal
Published: June 2023

Purpose
Any type of waste that is produced during medical treatments is called biomedical waste. Because BMW is a complex waste with high degree of quantitative and qualitative variations which arise due to the practices followed by the hospital staff in handling of waste, it is very crucial to analyse the knowledge and attitude of the waste handlers. A qualitative study was thus conducted to assess the knowledge, attitude and practices followed for bio medical waste management by the hospital staff of government and private hospitals of Alwar.
Methods
For this a questionnaire was distributed to 335 respondents and based on the scorecard for the Knowledge, Attitude and Practice scores KAP index was evaluated.
Results
The KAP index as per the scorecard came to be satisfactory for both government and private hospitals, though it was on a better side for the govt hospital staff; indicating a slightly better biomedical waste management in government hospitals as compared to private hospitals. When the socio demography of the respondents was associated with the KAP index it was found that age, occupation, experience and training influenced the KAP index as the P value was > 0.05. Correlation analysis results showed a positive and strong correlation between all the three parameters i.e. Knowledge, Attitude and Practice for bio medical waste management.
Conclusions
The KAP scorecard highlighted that the score of the cleaners, who have the prime responsibility of handling biomedical waste, was moderate so biomedical waste management needs improvements in the hospitals of Alwar.
Identification of disulfidptosis-associated IncRNAs signature and immune response of bladder urothelial carcinoma
Authors: Zhu Shusheng , Fan Yanpeng , Tang Chao
Published: June 2023

Bladder urothelial carcinoma (BLCA) is the most common malignancy of the urinary tract, with a wide range of clinical symptoms and prognosis. Disulfidptosis is newly identified cell death method and closely associated with BLCA progression, prognosis, and treatment outcome. Currently, we need to construct a new prognostic model of disulfidptosis-related long noncoding RNAs (drlncRNAs) to improve the treatment strategy of BLCA. Methods The data of BLCA samples were obtained from The Cancer Genome Atlas (TCGA), then 10 unique disulfidptosis-related genes (DRGs) were obtained from the research papers. The differences between the two groups showed in this study were used to create the “disulfidptosis-related long noncoding RNAs score” (disulfidptosis-score) prognostic model. Results We identified two groups of drlncRNAs with high and low disulfidptosis scores in this study. Patients with low disulfidptosis scores had a better overall survival rate compared to those with high scores in bladder cancer, and the high disulfidptosis score subtype exhibited more active malignant pathways related to cancer than the low score subtype. We found that the low disulfidptosis-score subgroup had better prognosis than the high disulfidptosis-score subgroup. The expression of mutation burden (TMB) was much higher in the low disulfidptosis-score group than in the high disulfidptosis-score group. The low disulfidptosis-score subgroup of patients exhibited significantly higher proportions of plasma cells, T cells CD8, and Tregs, while the high-risk subgroup had a greater abundance of Macrophages M0 and Macrophages M2. The disulfidptosis-score showed a strong correlation with the sensitivity of chemotherapeutic drugs, and patients in the low disulfidptosis-score group were more likely to exhibit an immune response and respond positively to immunotherapy. Additionally, we developed a nomogram to enhance the accuracy of the disulfidptosis-clinical score. Conclusion Based on our investigation of disulfidptosis-score in BLCA, disulfidptosis-score may have an important role in TME, prognosis, and drug sensitivity. We also investigated the significance of the disulfidoptosis-score in relation to immunotherapy and immune response, providing a basis for improving prognosis and responding to immunotherapy among patients with BLCA.
Efferocytosis is restricted by axon guidance molecule EphA4 via ERK/Stat6/Mertk signaling following brain injury
Authors: Soliman Eman , Leonard John , Basso Erwin Kristobal , Gershenson Ilana , Ju Jing , Mills Jatia , Jager Caroline , Kaloss Alexandra M. , Elhassanny Mohamed , Pereira Daniela , Chen Michael , Wang Xia , Theus Michelle H.
Published: June 2023

Background
Efferocytosis is a process that removes apoptotic cells and cellular debris. Clearance of these cells alleviates neuroinflammation and prevents the release of inflammatory molecules and promotes the production of anti-inflammatory cytokines to help maintain tissue homeostasis. The underlying mechanisms by which this occurs in the brain after injury remains ill-defined.
Methods
We demonstrate using GFP bone marrow chimeric knockout (KO) mice, that the axon guidance molecule EphA4 receptor tyrosine kinase is involved in suppressing Mertk signaling in the brain to restrict the function of efferocytosis on resident microglia and peripheral-derived monocyte/macrophages.
Results
Single-cell RNAseq identified Mertk expression, the primary receptor involved in efferocytosis, on monocytes, microglia, and a subset of astrocytes in the damaged cortex following brain injury. Loss of EphA4 on infiltrating GFP-expressing immune cells improved functional outcome concomitant with enhanced efferocytosis, and overall protein expression of p-Mertk, p-ERK, and p-Stat6. The percentage of GFP+ monocyte/macrophages and resident microglia engulfing NeuN+ or TUNEL+ cells was significantly higher in KO chimeric mice. Importantly, mRNA expression of Mertk and its cognate ligand Gas6 was significantly elevated in these mice compared to wild-type. Analysis of cell-specific expression showed that p-ERK and p-Stat6 co-localized with Mertk-expressing GFP + cells in the peri-lesional area of the cortex following brain injury. Using an in vitro efferocytosis assay, co-culturing pHrodo-labeled apoptotic Jurkat cells and bone marrow (BM)-derived macrophages, we demonstrate that efferocytosis efficiency and mRNA expression of Mertk and Gas6 was enhanced in the absence of EphA4. Select inhibitors of ERK and Stat6 attenuated this effect confirming that EphA4 suppresses monocyte/macrophage efferocytosis via inhibition of the ERK/Stat6 pathway.
Conclusions
Our findings implicate the Mertk/ERK/Stat6 axis as a novel regulator of apoptotic debris clearance in brain injury that is restricted by peripheral myeloid-derived EphA4 to prevent the resolution of inflammation.
An Injectable and Thermosensitive Hydrogel with Nano-aided Phototherapeutic and Chemical Effects for Periodontal Antibacteria and Bone Regeneration
Authors: Wang Weixiang , Zhang Guorong , Wang Yanyi , Ran Jianchuan , Chen Lin , Wei Zheng , Zou Huihui , Cai Yu , Han Wei
Published: June 2023

Periodontitis is a common public health problem worldwide and an inflammatory disease caused by periodontal pathogens. Porphyromonas gingivalis (P. gingivalis) is the most dominant bacteria in periodontitis and cause irregular defect of periodontal tissue. Both antibacterial therapy and bone regeneration are of great importance in the treatment of periodontitis. In this study, injectable and thermosensitive hydrogels with 3D networks were used as carriers for controlled release of osteo-inductive agent (BMP-2) and Near Infrared Region-II (NIR-II) phototherapy agents (T8IC nano-particles). T8IC nano-particles were prepared by reprecipitation and acted as photosensitizer and crosslinkers of the hydrogel under 808 nm laser irradiation. Besides, we promoted photodynamic therapy (PDT) through adding H2O2 to generate more radical oxygen singlet (ROS) and facilitate the antibacterial effect instead of increasing the temperature of photothermal therapy (PTT). Hydrogel + T8IC + Laser + BMP-2 + H2O2 incorporated with mild PTT (45°C), enhanced PDT and sustained release of BMP-2. It was present with excellent bactericidal effect, osteogenic induction and biosafety in vitro and in vivo. Besides, it was confirmed that PTT and PDT could promote bone regeneration through alleviating inflammation state. Altogether, this novel approach with synergistic antibacterial effect, anti-inflammation and bone regeneration has a great potential for the treatment of periodontitis in the future.
CNN-HT: A Two-Stage Algorithm Selection Framework
Authors: Xu Siyi , Liu Wenwen , Wu Chengpei , Li Junli
Published: June 2023

The No Free Lunch theorem tells us that no algorithm can beat other algorithms on all types of problems. The algorithm selection structure is proposed to select the most suitable algorithm from a set of algorithms for an unknown optimization problem. In this paper, an innovative algorithm selection approach called the CNN-HT two-stage algorithm selection framework is introduced. In the first stage, a Convolutional Neural Network (CNN) is employed to classify problems. In the second stage, the Hypothesis Testing (HT) technique is used to suggest the best-performing algorithm based on the statistical analysis of the performance metric of algorithms that address various problem categories. To provide a more general structure for the classification model, we adopt Exploratory Landscape Analysis (ELA) features of the problem as the input and utilize feature selection techniques to reduce the redundant ones. In problem classification, our proposed algorithm selection framework achieves an average accuracy of 96% for the classification of unknown black-box problems, and it improves to 98.8% after feature selection. This shows that our proposed classification method can accurately classify BBOB problems into 24 classes of problems and thus can correctly recommend algorithms accordingly. The performance of CNN-HT is compared with a single optimization algorithm on a continuous black-box optimization problem set, and the average ranking of CNN-HT is superior, demonstrating its effectiveness.
Saccharum officinarum Bio-coagulant for Palm Oil Mill Effluent Treatment
Authors: Bahrodin Muhammad Burhanuddin , Zaidi Nur Syamimi , Hussein Norelyza , Zhan Loh Zhang , Silanpää Mika , Kadier Abudukeremu
Published: June 2023

The coagulation process has become a common treatment method in water and wastewater treatment but not in palm oil mill effluent (POME) treatment. POME is known to have a high level of COD and turbidity and prior studies showed that the modified coagulation process using bio-coagulant may be feasible to remove primarily the COD and turbidity of the POME. In this study, an extract of Saccharum officinarum or bagasse is used as a source of bio-coagulant for the removal of COD and turbidity from POME at optimized coagulant dosage, pH, and contact time. The optimization was carried out via response surface analysis. This analysis stipulated that the application of Saccharum officinarum extract removed turbidity of more than 95%, COD of more than 65.0% with coagulation activity of 67.4% at optimum 50 mg/L coagulant dosage, pH 8, and slow mixing for 30 minutes. Henceforth, this study concludes the suitability of Saccharum officinarum as a bio-coagulant to primarily remove organic and solid pollutants during POME pre-treatment.
In vitro anthelminthic activity and secondary metabolites analysis of leaves of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) against bovine parasite Onchocerca ochengi and drug resistant strains of the free-living nematode Caenorhabditis elegans
Authors: Kalmobé Justin , Vildina Jacqueline Dikti , Boursou Djafsia , Menga Honoré Ndouwé Tissebé , Fogue Simeon Kouam , Ndjonka Dieudonné
Published: June 2023

Background
Human onchocerciasis caused by the filarial worm, Onchocerca volvulus is a parasitic that forms nodules under the skin. In the developing countries, it has been estimated that more than 80% of the population rely on traditional medicines for their primary healthcare needs. The aim of this work was to assess the nematicidal activities of Aloe vera on Onchocerca ochengi and Caenorahbditis elegans and to determine the phytochemical compounds.
Methods
Nodules were collected from the umbilical region of infected cattle, dissected and male worms were cultured in RPMI-1640. Worms were incubated for 48 h and 72 h with different concentrations of A. vera extracts in RPMI-1640 and M9-buffer. Polyphenol, tannin and flavonoid contents of extract were determined by using gallic acid and rutin as standards. The antioxidant activity was evaluated by DPPH radical scavenging method.
Results
The anthelmintic effect of A. vera extract against O. ochengi was concentration dependent with LC50 of 20.71 µg/mL and 11.75 µg/mL after 48 and 72h respectively. A. vera extract exerted concentration dependent lethal effects (LC50 = 2747 and LC50 = 1937 µg/mL) against C. elegans (WT). MeOH-CH2Cl2 of A. vera extract exhibited high DPPH activity with an IC50 value of 15 µg/mL and 9 µg/mL for ascorbic acid. The highest activity in adult worms was observed with the MeOH (100: 0) and AcOEtMeOH fractions with LC50 values of 12.82 and 15.50 µg/mL respectively. EcOEtMeOH (8:2 v/v) was more effective (LC50 = 250 µg/mL) on WT C. elegans. A. vera contains polyphenols (1015.05 and AcOEtMeOH = 893.60), flavonoids (25.35 and MeOH = 225.76) and tannins (401.37 and Hex = 788.89).
Conclusions
A. vera showed in vitro nematicidal activity against O. ochengi and C. elegans. Aloe vera could be used as alternative anthelmintic for onchocerciasis treatment.
Network based on epoch-to-epoch adaptation weighted triplet loss for person re-identification
Authors: Wang Jiajing , Yang Mingqiang , Wu Bin
Published: June 2023

Person re-identification (Re-ID) aims to use computer vision techniques to determine whether a specific person is present in a set of images. With the widespread use of deep learning, how to efficiently make the deep neural network for person Re-ID achieve excellent performance has gained wide attention. In this paper, we propose a metric learning method based on a new Epoch-to-epoch Adaptation Weighted (EAW) triplet loss function. The EAW triplet loss function uses the variability and connectivity of metric information between epochs to guide the optimization direction of the network. It enhances the inter-class differentiation through the adaptive weight and margin, speeds up the convergence of the network, and improves accuracy without increasing cost. Meanwhile, to prevent the risk of overfitting due to the complex loss function, we regularly employ sample pairing to optimize the network. We conduct evaluation experiments on both Market-1501 and DukeMTMC-reID datasets. With the same network, our loss function can effectively improve the network performance. On the Market-1501, our method achieves 95.3% rank-1 accuracy and 89.2% mAP and on the DukeMTMC-reID, the mAP and rank-1 accuracy can reach 90.4% and 80.4% respectively. The experiments show that our method can effectively improve the accuracy and training efficiency.
Advantages of 99mTc-CNDG SPECT/CT over Enhanced CT in the Staging of Non-Small Cell Lung Cancer
Authors: Wang Qinfen , Deng Zhensheng , Lu Chuangang , Chen Lijun , Qin Jiangjun , Wang Ping
Published: June 2023

Objective To explore the value of 99mTc-isonitrile deoxyglucosamine (CNDG) SPECT/CT in the staging and resectability diagnosis of non-small cell lung cancer (NSCLC) compared with enhanced CT.
Methods This research was approved by the hospital ethics review committee. Sixty-three patients with NSCLC received 99mTc-CNDG SPECT/CT, enhanced CT and initial TNM staging before treatment. Thirty-three patients who underwent radical surgery took postoperative pathological TNM staging as the reference standard.Another thirty patients who underwent radiochemotherapy,among them the reference standard of 7 patients of N staging and 5 patients of M staging was based on biopsy pathology，and the diagnosis of the remaining lesions was confirmed by at least one different image or clinical imaging follow-up for more than 3 months. The McNemar test and receiver operating characteristic (ROC) curve analysis were used to compare the diagnostic accuracy of staging and resectability of 99mTc-CNDG SPECT/CT and enhanced CT in NSCLC，respectively.
Results For all patients and surgical patients, the accuracies of 99mTc-CNDG SPECT/CT in diagnosing the T stage and N stage were higher than those of enhanced CT (all patients: 90.5%, 88.9% vs. 79.4%, 60.3%; surgical patients: 81.8%, 78.8% vs. 60.6%, 51.5%),and the differences were statistically significant (all patients: T stage, P=0.016; N stage, P =0.000; surgical patients: T stage, P =0.016; N stage, P =0.004). For all patients，the accuracy of 99mTc-CNDG SPECT/CT in diagnosing the M stage was higher than that of enhanced CT(96.8% vs. 90.5%), but the difference was not statistically significant (P =0.289).ROC curve analysis showed that the accuracy of 99mTc-CNDG SPECT/CT in diagnosing the potential resectability of NSCLC was significantly better than that of enhanced CT(P=0.046).
Conclusion This preliminary clinical study shows that 99mTc-CNDG SPECT/CT is of great value for accurate clinical staging of NSCLC compared with enhanced CT, and can significantly improve the accuracy of resectability diagnosis.
Habitat and population structure determine patterns of plant-pollinator networks of an endangered palm tree in a grassland-forest ecotone
Authors: Raguse-Quadros Mateus , Souza Gabriela da Cunha , Ferreira Pedro Maria Abreu , Blochtein Betina
Published: June 2023

Pollen transport by insects determines patterns of reproductive encounters between plants with flowers that have spatially or temporally segregated sexes. Pollinators show varied responses to environmental gradients such as those found in grassland-forest ecotones. Individual-based interaction networks are useful yet underexplored tools to understand how interactions vary across these gradients. Interactions between plant individuals and their pollinators directly reflect on plants fitness and genetic structure, seminal attributes for the conservation of endangered species. To test how a grassland-forest ecotone gradient can affect these interactions we studied pollination networks of Butia odorata individuals, an extinction-threatened palm tree from remnant palm grove ecosystems in South America. We evaluated how network metrics (specialization and modularity), and pollinator richness respond to gradients of habitat and population structure in a grassland-forest ecotone. Networks with more isolated palm trees showed greater specialization and modularity. Pollinator richness was dependent on the habitat context and pollinator role: peripheral pollinators were negatively affected by palm density, whereas core pollinators were positively affected by tree cover, which in turn was positively associated with palm density and proximity to the forest. Our results indicated that increased tree cover in the grassland matrix can promote pollinator diversity by decreasing the dominance of core species. Palm density may hamper the movement of pollinators pollen transportation, playing a key role for the conservation of B. odorataand for palm grove ecosystems. Finally, we emphasize the need of protocols that include traditional grassland management to achieve tree and palm tree density that maximizes conservation results.
A family of fractional analytic polynomials in generalized complex numbers and applications
Authors: Teodoro Antonio Di , Morillo Esteban , Ochoa--Tocachi Diego R. , Palacios Jose , Vela Erick
Published: June 2023

We present the development of fractional generalized complex calculus in the Riemann-Liouville sense, modifying the Cauchy-Riemann operator using the one-dimensional Riemann-Liouville derivative. We analyze the properties of the correspondent fractional analytic functions and introduce a family of analytic polynomials which are necessary to construct series expansions. We provide examples and visuals of these polynomials and use them to solve fractional differential equations and verify fractional Leibniz rule numerically.
Place-based Policy, Government Intervention and Public Service: Evidence from “The Construction of Third Front”
Authors: Zhang Haotian , Lu Shengfeng
Published: June 2023

This study examines the long-term effects of a significant place-based policy in China's history- “The Construction of Third Front”, which led to the relocation of significant amounts of industry and labor from coastal to inland regions under the central government's control. Using a spatially discontinuous design, we identify that the policy has resulted in a hindrance to the development public services in the affected regions over time, with the gap between these and the eastern regions continuing to widen. We argue that the overzealous intervention of the central government disrupted the efficiency of factor allocation in the TF region and caused a significant impact on supply and demand patterns for public services in this area, which persists even after the cessation of the policy.
JEL codes:H41, H50, O25
Endpoint Estimates for Commutators of Fractional Integral Operators on the p-Adic Vector Space
Authors: Chang Yunpeng , Wu Jianglong
Published: June 2023

In this paper, the main aim is to prove the weak type L log L estimates for commutators of fractional integral operators and the higher order in the context of the p-adic version of Lebesgue spaces, where the symbols of the commutators belong to the p-adic version of BMO space, in addition, we also establish the estimates of the sharp function on the p-adic vector space.
AMS(2020) Subject Classification: 42B35, 11E95, 26A33, 26D10
Variability of caffeine metabolism by CYP1A2 polymorphism in different populations
Authors: Chiarella Pieranna , Capone Pasquale , Sisto Renata
Published: June 2023

In 2015, the European Food and Safety Authority (EFSA) evaluated the worldwide consumption of coffee to verify the potential use and abuse of caffeine by the population, with the aim to identify potential adverse effects on the human health. The conclusion of the survey was the following: single doses of caffeine up to 200/400 mg did not give to any concern in the population.
Objectives: In 2015, the European Food and Safety Authority (EFSA) evaluated the worldwide consumption of coffee to verify the potential use and abuse of caffeine by the population, with the aim to identify potential adverse effects on the human health. The conclusion of the survey was the following: single doses of caffeine up to 200/400 mg wer not dangerous for the consumers.
Methods: Caffeine is one of the most widely consumed substance and beverage in the world, showing not only benefits, as excellent source of antioxidants, but also offering to prevent inflammatory and oxidative stress-related diseases, including obesity, metabolic syndrome and type 2 diabetes. In the elderly people with several comorbidities, caffeine contributed to reduce several neurological disorders, such as senile dementia, Alzheimer’s and Parkinson’s disease, contributing to alleviate tremors and helping the memory loss in elderly subjects.
Results: It is widely known CYP1A2 polymorphic enzyme (AA) (AC) (CC) is responsible for different levels in the caffeine metabolism, leading to a distinction in separate categories where CYP1A2*1A allele (AA) are "rapid" caffeine metabolizers, in contrast to carriers of the variant CYP1A2*1F who are "slow" caffeine metabolizers (AC-CC). In the absence of biological matrix, such as blood and urine, we performed in silicoanalysis of the genetic polymorphism CYP1A2*1A rs762551 distributed into five different ethnic groups of 210 subjects, including Caucasian, Africans, Americans, South Asians and East Asians.
Conclusions: The goal of this study is to identify potential significant difference in metabolism of caffeine to verify the most susceptible individuals in five ethnic groups.
Structured abstract
Coffee is one of the most widely consumed beverage in the world although it is not free from various effects and in 2015 the exposure to caffeine and the intake of daily coffee has been regulated by EFSA. Guidelines and EFSA results demonstrated caffeine is easily metabolized in the majority of subjects, although fast metabolizers are advantaged in contrast to other individuals with a slow metabolism.
Anti-inflammatory Effects of Boric Acid in Treating Knee Osteoarthritis: Biochemical and Histopathological Evaluation in Rat Models
Authors: Gundogdu Koksal , Gundogdu Gulsah , Miloglu Fatma Demirkaya , Demirci Tuba , Tascı Seymanur Yılmaz , El-Aty A. M. Abd
Published: June 2023

Objective: This study aimed to examine the anti-inflammatory properties of boric acid(BA) in treatingknee osteoarthritis(KOA) in rats, evaluating its biochemical and histopathological therapeutic effects.
Methods: The KOA rat model was induced by injecting monosodium iodoacetate into the knee joint. Random assignment was performed for the experimental groups as follows: group-1(control), group-2(KOA control), group-3(BA:4 mg/kg,orally), group-4(BA:10 mg/kg,orally), group-5 (BA:4 mg/kg,intra-articularly), and group-6(BA:10 mg/kg,intra-articularly). The rats received 100 µL of BA intra-articularly on days 1,7,14, and 21 or 1 mL orally once a day (5 days/week) for 4 weeks. Serum levels of interleukin-1β (IL-1β), tumor necrosis factor-α(TNF-α), and matrix metalloproteinase-13(MMP-13) were measured. Histopathological and immunohistochemical analyses were performed on knee joint samples using specific antibodies for IL-1β, TNF-α, MMP13, and nitric oxide synthase-2(NOS-2).
Results. Group-2 exhibited higher serum levels of IL-1β, TNF-α, and MMP-13 than group-1(P<0.05). However, these levels were lower in all treatment groups compared to group-2, with statistically significant reductions observed in groups-4,5, and 6. Histopathologically, group-2 displayed joint space narrowing, cartilage degeneration, and deep fissures. Groups-5 and 6 demonstrated significant joint space enlargement, articular cartilage tissue regeneration, and immunostaining patterns similar to those in group-1. Immunohistochemically, group-2 showed significant increases in IL-1β, TNF-α, MMP-13, and NOS-2 expression. However, all treatment groups exhibited reductions in these expression levelscompared to group-2, with statistically significant decreases observed in groups-5 and 6(P<0.01).
Conclusions. BA shows potential efficacy in reducing inflammation in experimental KOA models in rats. It may be a promising therapeutic agent for KOA, warranting further clinical studies for validation.
Synthesis of Nb2O5/C for H2O2 electrogeneration and its application for the degradation of levofloxacin
Authors: Valim Ricardo Bertholo , Carneiro Jussara Fernandes , Lourenço Julio César , Hammer Peter , Santos Mauro Coelho , Rodrigues Liana Alvares , Bertazzoli Rodnei , Lanza Marcos Roberto Vasconcelos , Rocha Robson da Silva
Published: June 2023

The present work sought to investigate H2O2 generation using a gas diffusion electrode composed of carbon with niobium oxide for the degradation of levofloxacin. Results showed that the oxide formed was Nb2O5 (crystallographic structure was confirmed by XRD; chemical composition detected by XPS) and the increase in the Nb/C ratio led to more crystalline structure and higher crystallite size. The carbon with 5% Nb2O5 presented an average particle size of 5.6 nm and this material led to the generation of the highest amount of H2O2 (317.6 mg L− 1). The C/5% Nb2O5-modified GDE was applied for the degradation of levofloxacin in an acid medium, in the presence and absence of Fe2+ ions. Long-term experiments conducted for the analysis of the time required for the total removal of levofloxacin showed that 96% of levofloxacin and 66% of organic load were removed in 270 min of treatment at the current density of 100 mA cm− 2.
Collaborative Capacity Planning Method of Wind-Photovoltaic-Storage Equipment in Microgrid Considering Different Energy Selling Income
Authors: Liang Lingyu , Zhao Xiangyu , Huang Wenqi , Sun Liming , Wang Ziyao , Chen Fengsheng
Published: June 2023

Microgrid is a promising small-scale power generation and distribution system. The selling price of wind turbine equipment (WT), photovoltaic generation equipment (PV), and battery energy storage equipment (BES) have a significant impact on the microgrid profits, which in turn affects the planning capacity of renewable energy. This paper proposes an optimal capacity planning method of wind-photovoltaic-storage equipment considering different energy selling income in microgrid. Stochastic characteristics of renewable energy (WT and PV), selling price of different energy, and timing coupling characteristic are considered in the proposed model. Besides, the configuration capacity of WT, PV and BES are modeled as discrete decision variables according to the type of specific equipment. And comprehensive life cycle cost (LCC) are considered as objective function. It can be found that the proposed collaborative capacity planning model is a mathematical programming problem with complex non-linear constraints and integer variables. To solve this problem, a cultural gray wolf optimization algorithm (CGWO) is applied in this paper. The proposed method's efficiency, convergence, superiority, and effectiveness are verified through a case study. Moreover, the impact of different new energy sales prices on capacity planning results is also revealed in the article.
Collaboration in Virtual Reality: Survey and Perspectives
Authors: Xanthidou Ourania Koutzampasopoulou , Aburumman Nadine , Ben-Abdallah Hanene
Published: June 2023

The application of Virtual Reality Environments (VRE) has been gaining momentum as a relatively new tool to assist with mitigating various difficulties including abstractness of concepts, lack of user engagement, perception of disconnection from other users. A VRE may offer both synchronous and asynchronous experiences, in addition to an immersive environment which promotes users’ engagement. Past research has shown that, in general, VRE do improve the experiences they try to enhance in many aspects of human activity. Terms like immersiveness and 3D representation of real life objects and environments are, as it appears, the two most obvious positive effects of Virtual Reality (VR) applications. However, despite these benefits it does not come without challenges. The main three concepts/challenges are the spatial design, the collaboration interaction between its members and the VRE, and the audio and video fidelity. Each of the three includes a number of other components that should be addressed for the total experience to be fine-tuned. These include mutual embodiment and shared perspectives, teleportation, gestural interaction, symmetric and asymmetric collaboration, physical and virtual co-location, inventory, and time and spatial synchronization. This paper comprises a survey of the literature, that identifies and explains the features introduced and the challenges involved with the VREs, and furthermore provides various interesting future research directions.
Development of Low-Threshold Detectors for Low-Mass Dark Matter Searches Using an N-Type Germanium Detector at 5.2 K
Authors: Bhattarai Sanjay , Mei Dongming , Raut Mathbar , Panth Rajendra , Kooi Kyler , Mei Hao , Wang Guojian
Published: June 2023

We investigated charge transport in an n-type germanium detector at 5.2 K to explore new technology for enhancing low-mass dark matter detection sensitivity. Calculations of dipole and cluster dipole state binding energies and electric field-dependent trapping cross-sections are critical to developing low-threshold detectors. The detector operates in two modes: depleting at 77K before cooling, or directly cooling to 5.2 K and applying different bias voltages. Results indicated lower binding energy of charge states in the second mode, at zero field and under an electric field, suggesting different charge states formed under different operating modes. Measured cluster dipole and dipole state binding energies at zero field were 7.88±0.64 meV and 8.37±0.75 meV, respectively, signifying high low-threshold potential for low-mass dark matter searches in the future.
SPCB-Net: A multi-scale skin cancer image identification network using self-interactive attention pyramid and cross-layer bilinear-trilinear pooling
Authors: Qian Xin , Han Qi , Wu Chen , Xu HongXiang , Hou Mingyang , Qiu Zicheng , Weng Tengfei , Zhou Baoping , Gao Xianqiang
Published: June 2023

Purpose Deep convolutional neural networks have made some progress in skin lesion classification and cancer diagnosis, but there are still some problems to be solved, such as the challenge of small inter-class feature differences and large intra-class feature differences, which might limit the classification performance of the model as high-level and low-level features are not properly utilized.
Methods This paper proposes a multi-scale skin cancer image identification network using self-interactive attention pyramid and cross-layer bilinear-trilinear pooling(SPCB-Net), which mainly consists of three proposed sub-modules that are the self-interacting attention pyramid (SAP), the across-layer bilinear-trilinear pooling operation and the global average algorithm(GAA).
Results The SPCB-Net is applied to two representative datasets of medical images in dermatology and histopathology (HAM10000 and NCT-CRC-HE-100K) to demonstrate the effectiveness of in the skin lesion classification. SPCB-Net（ResNet101） achieves 97.10% and 99.87% accuracy on HAM10000 and NCT-CRC-HE-100K respectively, which are both achieved performance improvements of 0.4% compared to the state-of-the-art models. In addition, a large number of experiments on HAM10000 show that the interactive attention pyramid(SPA) proposed in this paper is superior to the common attention module, and the method with a cross-layer bilinear-trilinear pooling is superior to the cross-layer trilinear pooling method.
Conclusion SPCB-Net is configured on Vgg19 and ResNet101 to evaluate the effectiveness of our proposed module. The experimental results show that SPCB-Net has shown state-of-the-art performance in the two field of dermatology and histopathology. Therefore, it is not only well qualified for the task of identifying skin cancer image but also has the potential to identify skin cancer by identifying pathological tissue.
Comparison of Vitamin D plasma level in women with or without endometriosis: a case-control study
Authors: Alizadeh Shima , Nasiri Dorna , Keikha Fatemeh , Khatami Farnaz , Panahi Zahra , Zamani Narges
Published: June 2023

Background:
Endometriosis is a debilitating gynecologic disease affecting millions of women worldwide. The potential role of vitamin D is of increasing interest. Previous studies have provoked controversy over the role of vitamin D and have shown a correlation between endometriosis and low vitamin D serum levels. This study aimed to assess and compare vitamin D serum levels between women with and without endometriosis.
Materials & Methods:
We studied 47 patients with endometriosis who visited the Infertility and Reproductive Clinic at our tertiary hospital and compared their vitamin D levels with healthy control subjects (47 women). The analysis was performed using Mann-Whitney and chi-square tests.
Results:
The median age of the women was 32/49, and SD was 5.42. The Mann-Whitney test showed no significant relationship between the mean levels of vitamin D and endometriosis diagnosis (P = 0.223). However, most of the patients with low level of vitamin D have endometriosis. This was confirmed by the chi-square test (odds ratio [OR] = 3.410; P = 0.008).
Conclusion:
In conclusion, these results indicate that women with a low level of vitamin D are statistically at higher risk of endometriosis and maybe there is a relationship between vitamin D and endometriosis so more studies are needed to determine the role of vitamin d in endometriosis
Healthy ageing in a multi-ethnic population: a descriptive analysis from the HELIUS study
Authors: Menassa Marilyne , Franco Oscar H. , Galenkamp Henrike , Born Bert-Jan H. van den , Vriend Esther M.C. , Vidal Pedro Marques , Stronks Karien , Charante Eric P. Moll Van
Published: June 2023

Background Ethnic health disparities have rarely been explored from a multidimensional ageing perspective. The objective of this study was to investigate these disparities in the Healthy Life in an Urban Setting (HELIUS) cohort using the Healthy Ageing Score (HAS).
Methods We computed the HAS using seven biopsychosocial domains from HELIUS baseline data (2011-2015), discerning between healthy, moderate, and poor ageing. We explored HAS differences by ethnicity, sex, and age group using Kruskal Wallis, Pearson Chi-squared, and multinomial logistic regression, adjusting for sociodemographic factors.
Results We included 17,091 participants (54.8% women, age (mean (SD)=44.5(12.8) years)) from South-Asian (14.8%) and African (20.5%) Surinamese, Dutch (24.3%), Moroccan (15.5%), Turkish (14.9%), and Ghanaian (10.1%) origins. The HAS (overall: poor (69.0%), moderate (24.8%), and healthy (6.2%)) differed between ethnicities (poorest in South-Asian Surinamese) and was poorer in women and post midlife (cut-off 45 years) across all ethnicities (all p≤0.0001). In the fully-adjusted models in men and women, poor ageing (vs. healthy ageing) was highest in the South-Asian Surinamese (aOR(95%CI)) (2.96(2.24-3.90) and 6.88(3.29-14.40), respectively) and the Turkish (2.80(2.11-3.73) and 7.10(3.31-15.24), respectively) groups compared to the Dutch, in the oldest age group (5.89(3.62-9.60) and 13.17(1.77-98.01), respectively) vs. the youngest, and in the divorced (1.48(1.10-2.01) and 2.83(1.39-5.77), respectively) vs. the married. Poor ageing was inversely associated with educational and occupational levels, mainly in men.
Conclusion Ethnic minorities displayed less healthy ageing than theDutch. This disparity appeared to be more pronounced in women, persisted before and after midlife, and was associated with sociodemographic factors that warrant further investigation.
Trust Management and Authentication Protocol for CWD- WPT Charging Stations
Authors: Roman Luis F. A. , Gondim Paulo R. L.
Published: June 2023

Electric vehicles (EV) have become an important alternative to reduce contamination and atmospheric pollution in the environment caused, in part, by cars, due to their emissions of carbon dioxide. The broad dissemination of EV's in society involves the solution of challenges related to EV charging and travel times, which still must be overcome. Some proposals have pointed to wireless charging while the EVs are driven (CWD) with wireless power transfer (WPT) technology through magnetic induction. However, there are some concerns over security and access control in the system due to the particularities of VANET-based scenario, which requires high performance for offering a safe and quality service. This paper introduces an authentication and access control protocol for a CWD-WPT charging system based on bilinear pairing and trust management. When compared to another one, the protocol shows good performance in terms of computational, energy, and communication costs. A comparative security analysis performed revealed an improvement by our proposal regarding security functionalities.