bluuebunny/crossref_metadata_2025 huggingface dataset:
Mixed Ligand of Mercury (II) Complexes of 4-Flouro-2-Cyanoaminothiophenolate with Amine or Triphenylphosphine as Co-Ligand
Authors: Mohammed Samar Sabah
Published: September 2024

The focus of this work is the preparation and characterization of mixed ligand mercury (II) complexes with involvement of 4-fluoro-2-cyanoaminothiophenalate (F-CAT) as the initial ligand and amine or triphenylphosphine (PPh3) as an additive ligand. The complexes were prepared by a straight forward method by increasing the solution of HgCl2 in ethanol and F-CAT and then adding the corresponding co-ligands (AlJanabi et al., 2017). The synthesized complexes were further scrutinized using various spectroscopy techniques such as UV-Visible, IR, and NMR. UV–Vis profiles further exhibited bands characteristic of LMCT transitions, which further validated the successful coordination of F-CAT and the co-ligands to the mercurate ion. Additional support to the observed successful coordination was extracted from the shifts in the proton resonance frequency signals obtained from 1H NMR. Furthermore, 31P NMR study of Hg(F-CAT) PPh3 exhibited that PPh3 has coordinated to the mercury center. The similarities to literature results underlined our results as coherent with the existing pattern of mercury (II) complexation. The investigations presented in this work advance the overall knowledge of mercury (II) coordination chemistry and provide unique visions for the use of HELM in catalysis, material sciences, and medicinal chemistry.
Role of CSF C- Reactive Protein in Rapid Diagnosis and Differentiation of Different form of Meningitis in Children
Authors: Bushaala Nagia M. , Elshibani Hana A. , Algazal Najat B. , Elfergani Mufeda A.
Published: September 2024

Background: Meningitis is a severe infection causing inflammation of the menengiase around the brain and spinal cord, primarily affecting infants, particularly neonates, leading to significant morbidity and mortality. Aim: This study aimed to investigate the significance of CSF Creative protein in the early diagnosis of bacterial meningitis and to compare the sensitivity of CSF C-reactive protein in the diagnosis of bacterial meningitis with other parameters in order to differentiate between bacterial meningitis and other meningitis. Method: A prospective cross-sectional study conducted at Benghazi Children’s Hospital in a period from February 2022 to February 2023. A total of 100 children out of them 50 cases as case-control groups randomly selected recruited for this study. The age, gender and symptoms of the cases were determined. A blood test and detailed cerebrospinal fluid (CSF) analysis, including blood and CSF CRP levels, were done. Results: The mean age of the study population was 9.12±5.89 months, ranging from 2 to 24 months. The mean age of meningitis cases was 7.42 ± 5.56 months. Almost half of cases fell in the age group (7–12) months. The distribution of cases with aseptic meningitis (27, 54%) was slightly higher than that with bacterial meningitis (23, 46%), totally; females (60, 60%) were more predominant than males (40, 40%). In bacterial meningitis cases, the female (14, 60.9%) gender was more predominant than male (9, 39.1%). All cases came with fever (27, 100%), and no cases came with convulsion (0, 00%), the mean level of CRP in blood was (199.13±59.31%), the level of CRP in CSF was (7.61±14.51), the mean concentration of white blood cell (WBC) in CSF was (219.48 ±161.76 x109/L)), the mean percent of neutrophils in CSF was (80±16.03%), the mean percent of lymphocyte in CSF (19.57±16.16)%), the mean concentration of sugar in CSF was (17.78±8.99mg/dl), the mean concentration of protein in CSF was (155.04±120.08mg/dl), and the mean count of red ...
Effects of Periprostatic Nerve Block Versus Combined Periprostatic Nerve Block and Intraprostatic Local Anesthesia in Transrectal Ultrasono Guided Prostate Biopsy
Authors: Moula Dr. S.M. Golam , Parvez Dr. M.M. Hasnat , Ali Dr. Md. Ibrahim , Badruddoza Dr. A. S. M. , Islam Dr. Md Majedul
Published: September 2024

Background: Although Transrectal ultrasound (TRUS) guided prostate biopsy is safe, patients experience significant pain during the procedure. In recent times, periprostatic nerve block (PNB) is the most preferable method for prostate biopsy, however, several studies suggested that PNB does not completely eliminate pain. Objective: This study aimed to compare the effect of PNB alone versus a combination of PNB and intraprostatic local anesthesia on pain reduction in TRUS guided prostate biopsy. Methods: A quasi-experimental study was conducted at Dhaka Medical College Hospital from January to December 2021. A total of 124 patients undergoing TRUS guided prostate biopsy were purposively included. Patients were divided into two groups using alternate sequence allocation: Group A (combined PNB and intraprostatic local anesthesia) and Group B (PNB alone). Pain was measured using the Visual Analogue Scale (VAS) during probe insertion, anesthetic infiltration, biopsy, and 30 minutes post-procedure. Biopsy-related complications were also recorded. Results: There were no significant differences between groups in terms of age (p=0.115), number of nodules (p=0.471), PSA levels (p=0.201), prostate volume (p=0.597), or procedure time (p=0.903). Pain scores during probe insertion and anesthetic infiltration were similar between the groups (p>0.05). However, during biopsy, Group A had significantly lower VAS scores (3.00 ±0.36) compared to Group B (4.79 ±0.58) (p<0.001). Thirty minutes after the procedure, Group A also reported significantly lower pain (VAS: 1.14 ±0.35) than Group B (VAS: 2.84 ±0.37) (p<0.001). Complications such as hematuria, dysuria, hematochezia, hematospermia, and UTI showed no significant difference between groups (p>0.05). Conclusion: Combining PNB with intraprostatic local anesthesia significantly reduces pain compared to PNB alone, without increasing complications.
Investigating the Serum Creatinine Levels in Wister Albino Male Rats to Examine the Impact of Cinnamon on Gentamicin-Induced Nephrotoxicity
Authors: Zahan Dr. Akter , Begum Prof. Dr. Mahmuda , Chowdhury Prof. Dr. Rama , Khanom Dr. Aklima , Sathi Dr. Meherunnesa , Nishat Dr. Rahatul Zannat
Published: September 2024

Background: The kidneys are two vital excretory organs. It can be harmed by the toxic effects of chemicals, poisons, or the extended and uncontrolled use of medications. Cinnamon is used to flavor pastries and dishes. This plant is one of the oldest medicinal plants used in traditional medicine as a potent medication that may have nephroprotective properties. Aim of the study: The purpose of our study was to investigate the serum creatinine levels in Wister Albino male rats to examine the impact of cinnamon on gentamicin-induced nephrotoxicity. Methods: This experimental study was conducted in the department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka from 1st January 2021 to 31st December 2021. A total number of thirty (30) apparently healthy Wister albino male rats, 90-120 days old, weighing between 150-200 gm were taken for the study. All acquired data was entered into a Microsoft Excel Work Sheet and analyzed using descriptive statistics in SPSS 22.0. Results: The mean (±SD) initial body weight of rats on day-1 were 177.10 ± 5.92, 183.80 ± 9.31 and 178.60 ± 8.19 gm, the final body weight on day- 29 were 208.40 ± 7.52, 207.0 ± 10.30 and 215.80 ± 9.26 gm. The percent (%) change of body weight from final to initial were 17.67 ± 0.98, 12.65 ± 1.23 and 20.85 ± 0.76 % and the kidney weight of rats were 0.86 ± 0.08, 1.25 ± 0.19 and 1.10 ± 0.18 gm in group A1, group A2 and group B respectively. the mean (±SD) kidney weight was significantly (p<0.001) higher in group A2 and group B (p< 0.01) in comparison to that of group A1. Whereas this levels were significantly (p<0.05) lower in group B in comparison to that of group A2. The mean (±SD) initial serum creatinine levels were 0.66 ± 0.08, 0.73 ± 0.05 and 0.74 ± 0.12 mg/dl, mean final serum creatinine level were 0.67 ± 0.07, 2.86 ± 0.07 and 1.60 ± 0.33 mg/dl, in group A1, group A2 and group B respectively. Conclusion: This study found that the gentamicin induced kidney damage was observed ............
Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination in the Treatment of Men with Androgenetic Alopecia
Authors: Yesmeen Dr. Maruna , Haque Dr. Farhana
Published: September 2024

Background: Platelet-rich plasma (PRP) therapy holds promise as a treatment for androgenetic alopecia (AGA). This study aimed to compare the clinical efficacy of PRP therapy, minoxidil, and their combination in treating men with AGA, and to evaluate PRP's effects on hair follicle (HF) cell proliferation via skin biopsy. Materials and Methods: This prospective study was carried out at tertiary hospital from June 2021 to June 2022. A total of 69 men were divided into three groups: PRP therapy, minoxidil, and combined therapy. Clinical efficacy was assessed through hair morphometrics, while cell proliferation was evaluated using antibodies against β-catenin, CD34, Ki67, and Dkk-1. Results: PRP therapy proved more effective than minoxidil (p = 0.005). Combined therapy significantly outperformed minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). Following PRP application, there was a notable increase in the absolute and relative expression areas of β-catenin and CD34, alongside a significant rise in the Ki67+ index. Conclusions: PRP represents a viable treatment option for AGA. Combining PRP with minoxidil shows promise in enhancing treatment outcomes for AGA by increasing HF cell proliferative activity and improving hair morphology.
Efficacy of Oral Methylphenidate and Risperidone in Treatment of Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial
Authors: Nahid Dr. Fauzia , Islam Dr. Ariful , Hoque Dr. Nazmul , Rahman Dr. Farhana , Ara Dr. Rawshan , Akhter Dr. Gulshan , Islam Dr. Tithi , Anjuman Dr. Habiba
Published: September 2024

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurobehavioral disorder of childhood. Worldwide approximately 5-12% of children have ever been diagnosed with ADHD. Dysregulation of frontal-subcortical-cerebellar catecholaminergic circuits and abnormalities of the dopamine transporter are the pathophysiology of ADHD. This site is the main target for medications such as psychostimulants e.g. methylphenidate for ADHD. In addition, to other pharmacological strategies, antipsychotic drugs such as Risperidone have been used for ADHD. The use of antipsychotic medication has been rising significantly for treating DBD in ADHD children. Objective: This study aimed to compare the effectiveness of oral Methylphenidate and Risperidone in children with ADHD. Methods: Conducted as a randomized controlled trial (RCT) at the Outpatient Unit of Pediatric Neurology, National Institute of Neurosciences and Hospital in Dhaka, Bangladesh, the study enrolled eighty children aged 3-14 years diagnosed with ADHD based on DSM-V criteria and confirmed by CPRS. Participants were randomly assigned to receive either Risperidone (experimental group, n=40) or Methylphenidate (control group, n=40). The efficacy and side effects of the medications were evaluated at 3-, 6-, and 12-week intervals, with changes in Conner's parent rating subscales and behaviour in school, family, community, and peer groups compared between the groups. Statistical analysis was performed using SPSS version 23. Results: Both medications demonstrated significant improvements in oppositional, cognitive, hyperactivity, and ADHD index sub-scales by the end of treatment. While the Risperidone group showed early response by 6 weeks, a substantial proportion of the Methylphenidate group required 12 weeks to respond. Academic performance, family dynamics, community engagement, and peer interactions improved in both groups, with a notably significant improvement observed in the Risperidone group at 6
DESAFIOS VIVENCIADOS PELO ENFERMEIRO OBSTETRA NO CUIDAR MULHERES COM MUTILAÇÃO GENITAL FEMININA
Authors: Coutinho Emilia
Published: September 2024

Introdução/Enquadramento: Algumas mulheres migrantes residentes em Portugal, que foram alvo de mutilação genital feminina, transmitem esse legado às suas filhas, por questões culturais. Neste contexto, é premente que o enfermeiro especialista em enfermagem de saúde materna e obstétrica (doravante designado enfermeiro obstetra) contribua para erradicar esta prática tradicional nefasta, e proteger as meninas das gerações vindouras.; Questão de investigação/Objetivos: : A questão de investigação norteadora é “Que vivências tem o enfermeiro obstetra, no cuidar mulheres, com mutilação genital feminina?” e o objetivo é “Compreender as vivencias, do Enfermeiro Obstetra, face aos desafios que se lhe colocam ao cuidar mulheres com Mutilação Genital Feminina”; Metodologia: Estudo qualitativo fenomenológico hermenêutico, apoiado nos pressupostos de Max van Manen, que defendem a importância que recai no entendimento e interpretação das experiências humanas para a prática de enfermagem. Para a recolha de dados foi utilizado um guião de entrevista fenomenológica e entrevistados 12 participantes que corresponderam aos seguintes critérios de inclusão: ser Enfermeiro Obstetra que preste, ou tenha prestado, cuidados preventivos e realizado notificação ou referenciação de casos de MGF; Resultados: Destacam-se duas categorias: “Constrangimentos vivenciados pelo Enfermeiro Obstetra no cuidado a mulheres submetidas à mutilação genital” e “Propostas a implementar pelo Enfermeiro Obstetra para a prevenção, notificação e intervenção para a erradicar a mutilação genital feminina”; Considerações Finais: As conclusões revelam que as práticas preventivas, de notificação e intervenção ainda estão aquém do que seria desejável. Urge investir e intensificar a formação dos profissionais de saúde em mutilação genital feminina tornando-os mais despertos e conhecedores sobre esta prática. A capacitação destes profissionais vai permiti-los empoderar as populações rumo à mudança de mentalidades, incluído as comunidades, onde a MGF é prevalente, tendo em vista a erradicação da mesma.
Synergistic Effects of Photosynthetic Bacteria and Endophytes: A Novel Approach to Enhance Cayenne Pepper Productivity
Authors: Avianto Yovi , Sari Nur Kartika , Pratama Ananta Bayu
Published: September 2024

Cayenne peppers (Capsicum frutescens) are a valuable commodity contributing significantly to the economy of Sleman Regency. Despite their substantial economic potential, cayenne pepper farming practices in Sleman often lack integration of sustainable and eco-friendly agricultural principles. This research aims to investigate the potential of utilizing photosynthetic bacteria and endophytic bacteria to enhance the growth and yield of cayenne peppers in Sleman Regency. The study was conducted in Gondang Lutung Hamlet, Donoharjo Village, Ngaglik District, Sleman. A randomized complete block design (RCBD) was employed with a single factor: beneficial bacteria type, including P1 (PSB + Endophyte), P2 (PSB), P3 (Endophyte), and P4 (Control). The findings revealed that the combination of photosynthetic bacteria and endophytic bacteria had varying effects on cayenne pepper growth. The combination treatment significantly enhanced plant height, chlorophyll content, flower number, fruit number per plant, fresh fruit weight, production, productivity, and resistance to C. capsici, C. gloeosporoides, and R. solanacearum. Single PSB application improved plant growth attributes, while Endophyte application demonstrated potential for enhancing cayenne pepper resistance to pathogens. The study demonstrates the potential of utilizing beneficial bacteria, particularly the combination of PSB and Endophyte, to enhance cayenne pepper growth, yield, and disease resistance. This research provides valuable insights for promoting sustainable and eco-friendly cayenne pepper farming practices.
Evaluation of Cloud Computing Implementation in Industry 4.0 at Cloud Infrastructure PT X
Authors: Haqi Muti Pertama , Adhariani Desi
Published: September 2024

The research aims to analyse impact of digital transformation at PT X as cloud infrastructure provider. Digital transformation has been increased globally because they have their internet infrastructure well established, meanwhile in Indonesia still needs to develop which has 3% annually of development headway. The usage of internet increases every year in every activity so that it supports the digital transformation. This research conduct to analyse by using PESTEL analysis and TOE framework at PT X as cloud infrastructure provider. The issues are found, at first cloud is used as a massive storage for certain activity such as for office needs. However, currently activities have been changed to be daily activities in cyber world so that generates big data. The next issue, cloud has been considered as environmental friendly product because it reduces usage of resources meanwhile for data centre activity consumes massive amount electricity so that contributes to create carbon emission. Digital transformation forms from various kind of cyber activities, this could be as potential market for PT X to elaborate their business. Unfortunately PT X profitability has fluctuated in this 5 years when the demands of technology increase. This research is a qualitative method with case study approach and the instrument of research is by doing interview. Data were gained as primary and secondary data. Current research is using PESTEL analysis and TOE framework. This explains external factors which identified by PESTEL analysis could affect business strategy and TOE framework could determine kinds of innovation based on its character of technology so that these analysis could bring the decision of company strategy.
Comparative Analysis of Factors Affecting Firm Value in the Conventional and Sharia Stock Index
Authors: Dewi Amanda Puspita , Sembiring Ferikawita Magdalena
Published: September 2024

This research aims to determine the effect of liquidity, profitability, good corporate governance and investment opportunity set on firm value in conventional and sharia stock index, namely is in Investor33 Indeks an Jakarta Islamic Index listed on the Indonesia Stock Exchange (IDX) for the 2017-2022 period. The sample selection used a purposive sampling technique, 21 samples of companies from 48 populations of Indeks Investor33 and 11 samples of companies from 53 populations of Jakarta Islamic Index. The data collection technique used was secondary data with data analysis technique using panel data regression analysis and using Eviews 10 software. The best model was obtained, namely is Fixed Effect Model (FEM). Based on the results of this research, it shows that partial liquidity has no effect on firm value in Investor33 Indeks and Jakarta Islamic Index. Profitability partially has a positive effect on the firm value in Investor33 Indeks, while profitability has no effect on the firm value of Jakarta Islamic Index. Good corporate governance partially has no effect on the firm value of Indeks Investor33, while good corporate governance has a positive effect on the firm value of Jakarta Islamic Index. Investment opportunity set partially has a positive effect on the firm value of in Investor33 Indeks and Jakarta Islamic Index. Apart from that, simultaneously liquidity, profitability, good corporate governance and investment opportunity set influence the firm value of in Investor33 Indeks and Jakarta Islamic Index. In this research, the firm value on the conventional and sharia stock indexes with the best performance on the IDX cannot be separated from other factors that can influence investors in assessing a company.
The Influence of Cash Flow, Net Profit and Company Size on Company Stock Prices in Automotive and Component Sub-Sector Companies Listed on the Indonesia Stock Exchange for the 2019-2022 Period
Authors: Sakinah Putri Atika Surya , Sherlita Erly
Published: September 2024

This research aims to determine the influence of cash flow, net profit and company size on stock prices in Automotive and Components Subsector companies listed on the Indonesia Stock Exchange for the 2019-2021 period. The factors tested in this research are cash flow, net profit, and company size as independent variables, while stock prices is the dependent variable. The research method used in this research is descriptive and verification methods. The population in this research is the Automotive and Components Subsector companies listed on the Indonesia Stock Exchange for the 2019-2021 period, totaling 12 companies. The sampling technique used was non-probability sampling with a saturated sampling method, so the total sample was 12 companies. The data analysis used is panel data analysis using the Eviews 13 program. The research results show that cash flow, net profit and company size affect stock prices. Apart from that, the research results also show that the influence of cash flow, net profit and company size in contributing to stock prices is 65.3%.
Epidemiologia das internações por Esclerose Múltipla entre 2020 a 2022
Authors: Cristovam Pina Guilherme , De Castro Queiroz Pereira Mateus , Silva Carvalhaes Deise , Ramos Vasconcelos Lara , Vitor Franco Dourado Manoel
Published: September 2024

A esclerose múltipla (EM) é uma doença crônica e degenerativa do sistema nervoso central que leva a uma variedade de sintomas neurológicos devido à inflamação e desmielinização. Este estudo explora a epidemiologia das internações por EM no Brasil entre 2020 e 2022, focando nas variações regionais, prevalência e fatores de risco associados. O estudo investigou a epidemiologia das internações por esclerose múltipla (EM) no Brasil de 2020 a 2022, analisando aspectos como variações regionais, prevalência e fatores de risco. A pesquisa utilizou uma metodologia epidemiológica quantitativa e retrospectiva, baseando-se em dados do Sistema de Informações Hospitalares do SUS, com análise focada em variáveis demográficas e clínicas através do Microsoft Excel. Os resultados indicaram uma maior incidência de internações na região Sudeste, possivelmente devido a uma melhor infraestrutura de saúde e maior densidade populacional. Observou-se um aumento geral no número de internações ao longo do período analisado, com destaque para o aumento significativo na região Centro-Oeste. A discussão sugere que o aumento de casos pode ser atribuído a uma maior conscientização e avanços no diagnóstico. Foi também notada a coexistência da EM com outras comorbidades, reforçando a necessidade de um tratamento integrado e abordagens de saúde pública que garantam acesso equitativo ao diagnóstico e tratamento, especialmente nas regiões com maior número de internações. O estudo ressalta a importância de políticas de saúde informadas e adaptadas às características regionais para um manejo eficaz da EM no Brasil.
Histerectomia: Uma análise abrange sob a ótica cirúrgica
Authors: Vieira Soares Tasla , Rodrigues Lassala Juliana , Letycia Gomes Alencar Júlia , Rosado Costa Gabrielle , Albuquerque Egito Ingrid , Vitória Sabino Hupp Maria , de Souza Lima Ana Carolaine , Puccini Venturin Duarte Sarah Maria , Guimarães Figueiredo Cavalcante Maria Clara , Marques Volponi Lucas
Published: September 2024

A histerectomia, procedimento cirúrgico para remoção do útero, é amplamente realizada globalmente, indicada para condições como fibromas, endometriose severa, prolapsos e câncer ginecológico. Este artigo visa analisar as técnicas cirúrgicas modernas, suas indicações e desafios, com ênfase em inovações tecnológicas que promovem uma recuperação mais eficaz e melhor qualidade de vida para as pacientes. Utilizou-se a revisão da literatura como metodologia principal, explorando bases de dados como PubMed, MedlinePlus, SciELO e Google Acadêmico. Os artigos selecionados abordaram técnicas cirúrgicas e resultados pós-operatórios de pacientes submetidas à histerectomia. A pesquisa adotou uma abordagem qualitativa e exploratória para coletar e analisar dados relevantes. As técnicas cirúrgicas variam amplamente, com escolhas influenciadas por condições clínicas e preferências pessoais. As técnicas mais comuns são a histerectomia abdominal, vaginal e laparoscópica. Os resultados apontam que técnicas menos invasivas, como a laparoscópica, tendem a reduzir a perda sanguínea, complicações pós-operatórias e acelerar a recuperação. Além dos impactos físicos, a cirurgia afeta significativamente o bem-estar psicológico e social das mulheres, com muitas reportando melhorias em sua qualidade de vida e função sexual após o procedimento. A histerectomia é uma intervenção que vai além da remoção de um órgão, envolvendo considerações clínicas complexas e impactos significativos na vida das pacientes. A evolução das técnicas cirúrgicas e a escolha cuidadosa dos profissionais são cruciais para o sucesso do procedimento. A comunicação efetiva entre médico e paciente é fundamental para alinhar expectativas e preparar a paciente para uma recuperação satisfatória. Continuar a pesquisa e o aprimoramento das práticas cirúrgicas é essencial para avançar no cuidado e na qualidade de vida das mulheres submetidas à histerectomia.
Citologia vaginal de cadelas submetidas à aplicação de anticoncepcionais injetáveis
Authors: Borges Talita Bianchin , Sala Pollyana Linhares , Leitzke Arthur Venicius Sbaraini , Dissenha Adrielly , Belettini Salviano Tramontin , Paula Dalila Soares de , Sá Thaís Camaso de , Ribeiro Rita de Cássia Lima , Quessada Ana Maria
Published: September 2024

Anticoncepcionais para cadelas são fármacos à base de progestágenos que inibem o estro destes animais. Todavia estes anticoncepcionais podem causar efeitos colaterais graves. Entretanto, quando utilizados na fase correta do ciclo estral (anestro) e na dose adequada, os anticoncepcionais podem ser administrados com segurança nas cadelas. Porém, o reconhecimento do ciclo estral das fêmeas caninas só é possível por meio de exames laboratoriais, sendo o mais efetivo a citologia vaginal. Com o objetivo de realizar citologia vaginal em cadelas submetidas à aplicação de anticoncepcionais, tais fármacos foram administrados em 10 cadelas em diferentes fases do ciclo estral. Em todas as cadelas foram realizados exames clínicos e citológicos vaginais antes da administração, 30 e 90 dias após a aplicação do fármaco. Ao término dos 90 dias as cadelas foram castradas. Observou-se que antes da aplicação do fármaco três cadelas estavam em proestro, três no estro, três em diestro e uma em anestro. Aos trinta e noventa dias, apenas uma cadela que estava em proestro no início, continuou nesta fase em todas as etapas. As demais fêmeas entraram em outras fases do ciclo estral. Concluiu-se que a citologia vaginal é uma ferramenta útil para se detectar a fase do ciclo estral de cadelas; os anticoncepcionais aplicados na dose recomendada (bula) apresentam comportamento biológico irregular, mesmo em cadela em anestro. Sugere-se que o fármaco seja comercializado sob estrita supervisão veterinária.
Abordagem ao paciente com doença pulmonar obstrutiva crônica (DPOC) e comorbidades cardiovasculares
Authors: Estenio Lopes Neto  , Renata de Oliveira Galvão  , Georgia Mussa Bastos Marques  , Gbètoho Désiré Djossou  , Guilherme Plácido Barbosa  , Helio Hayato Guimarães Hiwatashi  , Bruna Portela Lourenço  , Petrus Bezerra Martins  , Ana Valquíria Santos e Gomes  , Raul Cordeiro Pessanha  , Kássia Rejane Oliveira Bueno  , Roby Alexandre Vaz  , Ana Lígia Duarte Viana Gadelha  , Guilherme França Cavalcante  , José Eldo dos Santos Filho
Published: September 2024

A Doença Pulmonar Obstrutiva Crônica (DPOC) é uma condição prevalente que frequentemente coexiste com comorbidades cardiovasculares, complicando o manejo clínico e influenciando negativamente o prognóstico dos pacientes. Este estudo tem como objetivo revisar a literatura recente sobre a inter-relação entre DPOC e comorbidades cardiovasculares, e avaliar estratégias de manejo integrado. Utilizou-se uma revisão integrativa nas bases de dados Scientific Electronic Library Online (SCIELO) e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), com descritores como “DPOC”, “comorbidades cardiovasculares” e “manejo clínico”. Os resultados indicam que a presença de comorbidades cardiovasculares agrava os desfechos clínicos de pacientes com DPOC, ressaltando a importância de uma abordagem multidisciplinar para o tratamento. Conclui-se que estratégias personalizadas e um cuidado integrado são essenciais para melhorar a sobrevida e a qualidade de vida desses pacientes.
Comparação Entre as Vias de Parto e os Impactos no Recém-Nascido
Authors: Lara Cardoso Vanessa , De Oliveira Caixeta Mariana , Messias de Almeida Santos Sabrina , Gomes Filemon Bernardes Dhiego , De Lima Enzo Gabriel , Montijo Borges Taveira Maysa , De Almeida Cavalcanti Sabatini Murillo , De Almeida Cavalcanti Sabatini Murillo , Machado Silva Geovana , Arantes Mendonça Lara Ohanna , Cruz Oliveira Ismael Vitor , Pereira Sousa Gleivisson , Ornelas Almeida Vinícius , Gonçalves Marinho Taynara , Gomes Guida Camila
Published: September 2024

Introdução: O parto vaginal é O método natural, favorecendo uma adaptação eficiente ao ambiente externo e uma recuperação rápida para a mãe, mas pode apresentar riscos como traumas perineais e sofrimento fetal. A cesariana, embora essencial em casos de complicações, pode prolongar a recuperação materna e está associada a um aumento nas complicações respiratórias neonatais e a possíveis implicações a longo prazo para a saúde do bebê. Objetivos: Analisar a literatura disponível sobre o tema e comparar os efeitos que as vias de parto causam no recém-nascido. Métodos: Trata-se de uma revisão da literatura utilizando as bases de dados SciELo e Google Acadêmico. Resultados e discussão: Os resultados revelam que bebês nascidos por parto vaginal geralmente têm uma adaptação mais eficaz ao ambiente extrauterino. Em contraste, a cesariana, especialmente quando realizada antes do início do trabalho de parto, pode levar a necessidade de cuidados intensivos neonatais. Conclusão: A escolha da via de parto deve ser cuidadosamente individualizada, levando em consideração tanto os benefícios para o bebê quanto os riscos para a mãe, baseando-se em evidências clínicas e nas circunstâncias específicas de cada caso.
The Sleep Revolution: Uncovering the Deep Impact of Rest on Well-being
Authors: Mehta Arjun
Published: September 2024

Sleep, a fundamental human need, plays a critical role in our physical, mental, and emotional health. Despite its importance, modern society often views sleep as a luxury rather than a necessity. This paper delves into the profound impact of rest on well-being, drawing on a wide array of interdisciplinary research from neurology, psychology, and public health to illuminate the consequences of sleep deprivation and the transformative power of quality sleep. Through quantitative analyses and qualitative case studies, we examine the correlation between sleep and various health outcomes, including stress resilience, chronic disease management, mental health stability, and overall life satisfaction. We also explore societal attitudes towards sleep and how these perceptions influence health policies and personal behaviors. Finally, this study advocates for a shift in public and medical discourse to place greater emphasis on sleep, proposing strategic interventions aimed at enhancing sleep education and accessibility. This research not only underscores the critical need for a societal shift in sleep awareness but also highlights practical strategies that can be employed to foster a healthier, more restful society.
INTEGRATING THE RESOURCE-BASED VIEW AND DYNAMIC CAPABILITIES: A COMPREHENSIVE FRAMEWORK FOR SUSTAINING COMPETITIVE ADVANTAGE IN DYNAMIC MARKETS
Authors: Wenjie Sun  , Kecun Chen  , Jianhua Mei
Published: September 2024

In today's rapidly evolving business environment, sustaining competitive advantage demands an integrated approach that combines the strengths of both the Resource-Based View (RBV) and Dynamic Capabilities (DCs). RBV emphasizes the importance of valuable, rare, inimitable, and non-substitutable (VRIN) resources as key drivers of long-term success. However, its static nature limits its effectiveness in dynamic markets where adaptability is crucial. Dynamic Capabilities address this gap by focusing on a firm's ability to sense opportunities and threats, seize opportunities, and transform resources in response to external changes. This paper proposes an integrated framework that leverages VRIN resources while enhancing the firm's adaptability through Dynamic Capabilities. The framework offers a strategic guide for firms to balance the protection and exploitation of core resources with the development of capabilities necessary for continuous innovation and flexibility. Empirical applications suggest that this dual approach is particularly effective in industries characterized by high volatility and technological disruption. By integrating RBV and DCs, firms can better navigate uncertainty, ensuring sustained competitive advantage in a rapidly changing marketplace.
KEYWORDS: Resource-Based View, Dynamic Capabilities, Competitive Advantage, Strategic Management, VRIN Resources, Adaptability.
Bədii mətnlərdə üslubi fiqurların rolu
Authors:   AEM ( Azerbaijan Science Center ), Əsgərova Şəhanə
Published: September 2024

Xülasə Məqalədə fransız dilində yazılmış bədii mətnlərdə ən çox istifadə olunan üslubi fiqurlardan bəhs olunur. Elmi, publisistik mətnlərdən fərqli olaraq bədii mətn daha rəngarəngdir. Bədii mətnlər daha zəngin dil xüsusiyyətlərinə malikdirlər. Bədii mətnlərdə əsas xammal olan sözdən məharətlə seçib işlətmək tələb olunur. Sözün əlavə məna kəsb etməsi, müəyyən fonetik dəyişikliyə məruz qalması, sözlərin məna köçürülməsi, cümlə konstruksiyasının dəyişməsi nəticəsində obrazlı ifadələr olan üslubi fiqurlar yaranır. Üslubi fiqurlar müəyyən standartdan kənaraçıxma nəticəsində yaranır. Üs­lubi fiqurlar daha ekspressiv, emosional və obrazlı ifadələrin yaranmasına xidmət edir. Fransız dil­çilik ədəbiyyatında troplar da fiqurlara aid edilir. Həm məcazlar, həm də fiqurlar nitq emosi­onal­lığını artıran vasitələrdir. Yazıçı frazeoloji, leksik və fonetik dil vahidlərindən istifadə edərək fikrini oxucuya daha təsirli ifadələrlə çatdırır. Yaranmasına görə fiqurlar müəyyən təsnifat əsasında qrup­laşdırılmışdır. Üslubi fiqurlar (metafora, metonimiya, sinekdoxa, təcəssüm, təkrir, antiteza, allite­rasiya və s.) bədii əsərlərdən seçilmiş nümunələr əsasında verilmiş və onların bədii mətnlərdə funk­siyaları araşdırılmışdır. Fiqurlar Kvintiliandan müasir dövrə qədər öz aktuallığını qoruyub saxla­mışdır.
Əli Səmədovun uşaq nağıllarının mətn informasiyası
Authors:   AEM ( Azerbaijan Science Center ), Məmmədova Şöhrət
Published: September 2024

Xülasə Azərbaycan uşaq nəsrinin inkişafında Əli Səmədovun ayrıca yeri vardır. Ümumiyyətlə, iyirminci əsrin 60-cı illəri ədəbi-nəzəri fikirdə xüsusi mərhələ olaraq səciyyələnir. Bunun isə əsaslı səbəbləri vardır və təkcə Azərbaycan miqyasında olan canlanma ilə şərtlənmir. Daha çox sovetlər məkanında, eləcə də Avropa mühitində baş verən oyanışlara, hərəkətliliyə bağlanır. “Altmışıncı illər nəsri” və yaxud da “altmışıncı illər nəsli” adı ilə səciyyələnən bu dövr bütün parametrlərdə eyni təsəvvürü və məzmunu canlandırır. Poeziyanın, nəsrin, dramaturgiyanın, publisistikanın, ədəbi tənqidin bu mərhələdəki özünəməxsusluq mənzərəsi milli düşüncənin, arxaik yaddaşın bir tendensiya olaraq hərəkətliliyinə, oyanışına bağlanması ilə spesifikləşir. Uşaq ədəbiyyatı da bu prosesdə özünəməxsus düşüncə modellərinin, həyatı dərk və təqdim üsullarının diqqətçəkici tərəfləri ilə səciyyələnir. Yaşlı nəslin nümayəndələri, eləcə də 60-cı illərdə böyük ədəbiyyata qədəm qoyan sənətkarların mühüm bir qismi uşaq ədəbiyyatı yaratmaq işində fəal rol oynadılar. M.Rzaquluzadə, M.Seyidzadə, M.Dilbazi, Ə.Cəmil, N.Rəfibəyli, R.Rza, S.Məmmədzadə, Y.Həsənbəy, V.Nəsib, C.Məmmədov, Ə.Kərim, C.Novruz, F.Sadıq, T.Mütəllibov, M.Namaz, A.Kəmərli, M.Əliyev və s. sənətkarların ədəbi-mədəni prosesdəki fəaliyyəti bütün aspektləri ilə zənginləşməyə köklənirdi. Bütün bunların ümumi ahəngi uşaq ədəbiyyatı yaratmaq işində gərəkli işlərin görülməsini diqqət önünə gətirir. Ə.Səmədov da uşaq ədəbiyyatına gələn istedadlı sənətkarlar içərisində öz ruhu, düşüncəsi ilə seçilən şəxsiyyətlərdən olmuşdur.
Naxçıvan musiqi folklorunun özünəməxsus cəhətləri
Authors:   AEM ( Azerbaijan Science Center ), Əsgərov Amil
Published: September 2024

Xülasə Naxçıvan – yaşı min illərlə ölçülən çoxəsrlik tarixə, zəngin maddi və mənəvi mədəniyyətə, bəşər tarixinin ilk dövrlərinə və sonrakı yüzilliklərə aid özünəməxsus arxeoloji və etnoqrafik abidələrə malik olan qədim Azərbaycan diyarıdır. Naxçıvan əsrlər boyu özünün zəngin təbii sərvətləri, heyrətamiz, gözəl və saf təbiəti, şəfaverici suları və bitkiləri ilə şöhrət qazanmışdır. Naxçıvan, eyni zamanda, Qədim və Orta əsrlərdə elmin, mədəniyyətin və incəsənətin bütün sahələri üzrə bəşəriyyətə böyük şəxsiyyətlər, yaradıcı dahilər bəxş etmiş bir məkandır. Azərbaycanın ayrılmaz parçası olan bu qədim diyarın elm, mədəniyyət, ədəbiyyat, incəsənət xadimlərinin yaratdığı qiymətli elmi, mədəni, ədəbi dəyərlər, maddi-mənəvi abidələri, o cümlədən, xalq yaradıcılığı, aşıq və muğam sənəti bütün Şərq mədəniyyətini zənginləşdirmiş və inkişaf etdirmişdir. Naxçıvanda görkəmli rəssamlar, memarlar və şairlər ilə yanaşı, rəqs sənətinin biliciləri, peşəkar muğam ifaçıları və ustad aşıqlar yaşayıb-yaratmışlar. Naxçıvanda fəaliyyət göstərən ədəbi mühitlərdə, musiqili-poetik məclislərdə, ənənəvi bayram mərasimlərində rəqqaslar, xanəndə və sazəndələr də fəal iştirak etmiş, daim muğamlar, təsniflər, xalq mahnıları səsləndirmişlər. Naxçıvan çox zəngin folklor mühitinə və ənənələrinə malikdir. Bu diyarın, demək olar, hər bir bölgəsi özünəməxsus folklor janrları, folklor-ifaçılıq ənənələri ilə seçilir. Naxçıvanın qədim yallı janrının ən çox yayıldığı region olması faktı da artıq elmi dəlillərlə təsdiqini tapmışdır.
Indicators of biochemical control of diabetes mellitus during limited availability of health service in the context of hypoglycemic therapy
Authors: Kleibert Marcin , Mrozikiewicz-Rakowska Beata , Korycka Klaudia , Płachta Iga , Bąk Patrycja Małgorzata , Bałut Daniel , Zieliński Jakub , Zgliczyński Wojciech
Published: September 2024

Aim: Type 2 diabetes mellitus (T2DM) is a widespread disease that leads to many complications if not adequately controlled. The pandemic and its limitations on healthcare access impaired the management of chronic conditions. The aim of our study was to examine its effects in context of different antidiabetic therapies on key health related factors in patients with T2DM.
Materials and Methods: To the study we enrolled 598 adult patients with diagnosed T2DM treated in diabetology outpatient department of the University Clinical Centre (UCC) of the Medical University of Warsaw. Data on body weight, glycated hemoglobin (HbA1c), and creatinine concentration were collected throughout the first COVID-19 pandemic wave and compared to the results obtained before the 4th of March, 2020 (1st confirmed COVID-19 case in Poland).
Results: The HbA1c mean baseline level was 7.15% (±1.39) and increased significantly (7.34% (±1.37), p=0.02) during observation. Importantly, the attendance of patients for HbA1c testing decreased by 57.82% in comparison to the pre-pandemic period. Similarly, creatinine concentrations increased (from 1.27 mg/dl (±0.76) to 1.34 mg/dl (±1.02), (p=0.004)). The increase in creatinine concentration was significantly lower in the group treated with regimens including metformin compared to other regimens. Somewhat surprisingly, the mean body mass remained unchanged.
Conclusions: The pandemic period had a significant impact on the tested biochemical parameters. The lesser changes of renal parameters in the group of patients treated with metformin confirms its nephroprotective effect and its value as a first-line treatment in T2DM.
Morphological and functional features of the colonic mucus barrier in patients with symptomatic uncomplicated diverticular disease and acute uncomplicated diverticulitis
Authors: Dorohavtseva Hanna A. , Dorofieiev Andrey E. , Dyadyk Olena O. , Myroshnychenko Mykhailo S.
Published: September 2024

Aim: The purpose was to identify the morphological and functional features of the colonic mucus barrier in patients with symptomatic uncomplicated diverticular disease and acute uncomplicated diverticulitis.
Materials and Methods: In the research, three groups were formed. Group 1 included fragments of the mucous membrane of the large intestine, which were collected from 12 people during autopsies. The results of autopsies and histological examination of the material did not reveal any gastrointestinal pathology. Group 2 included biopsies of the mucous membrane of the large intestine from the area of the diverticulum of 34 patients with symptomatic uncomplicated diverticular disease. Group 3 included biopsies of the mucous membrane of the large intestine of 26 patients with acute uncomplicated diverticulitis. Histological (hematoxylin and eosin staining), histochemical (PAS reaction) and immunohistochemical (mouse monoclonal antibodies to Mucin 2 (MUC2) and Mucin 4 (MUC4)) staining methods were used. A morphometric study was also carried out.
Results: In patients with diverticular disease, the authors identified disturbances in the morphofunctional state of the mucus barrier of the colon, the structure and function of goblet cells contained in its mucous membrane, characterized by a decrease in the thickness of the mucus layer covering the surface of the mucous membrane; a decrease in the size and number of goblet cells with a decrease in their mucus-producing ability; a change in the mucin profile, characterized by a violation of the content of MUC2 and MUC4. These changes were greatest in patients with acute uncomplicated diverticulitis compared with patients with symptomatic uncomplicated diverticular disease.
Conclusions: The identified disturbances in the morphofunctional state of the mucus barrier of the colon, structural and functional changes in goblet cells may be one of the mechanisms for the development of acute uncomplicated diverticulitis and symptomatic uncomplicated diverticular disease.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN GEOGEBRA TERHADAP KEMAMPUAN KOMUNIKAS MATEMATIS SISWA SMP
Authors: Naldi Lisna , Tamur Maximus , Jehadus Emilianus
Published: September 2024

Penelitian ini dilakukan untuk menganalisis perbedaan kemampuan komunikasi matematis antara siswa yang diajarkan menggunakan model pembelajaran kooperatif tipe STAD berbantuan Geogebra dengan siswa yang mendapat pembelajaran konvensional. Metode yang digunakan adalah penelitian eksperimen semu dengan menggunakan desain posttest-only control group design. Populasi dalam penelitian seluruh siswa kelas VIII SMPN 5 Langke Rembong Manggarai NTT dengan jumlah 152 orang pada tahun ajara 2022/2023. Pengambilan sampel dilakukan dengan random kelas. Sampel penelitian pada kelas eksperimen yaitu kelas VIII B dan kelas VIII A yang berjumlah 29 siswa sebagai kelas kontrol. Instrumen yang digunakan dalam penelitian ini adalah tes uraian. Teknik analisis yang digunakan adalah dengan uji-t. Dari analisis data ditemukan bahwa model pembelajaran kooperatif tipe STAD berbantuan geogebra berpengaruh positif terhadap kemampuan komunikasi matematis siswa. Pembahasan tentang temuan baru dan kelemahan penelitian disajikan sebagai ide dasar untuk penelitian lebih lanjut.
(This research was conducted to analyze differences in mathematical communication skills between students who were taught using the STAD type cooperative learning model assisted by Geogebra and students who received conventional learning. The method used is quasi-experimental research using a posttest-only control group design. The population in the study were all Grade VIII students of SMPN 5 Langke Rembong Manggarai NTT with a total of 152 people in the 2022/2023 academic year. Sampling was done by random class. The research samples in the experimental class were class VIII B and class VIII A, totaling 29 students as the control class. The instrument used in this study is a description test. The analysis technique used is the t-test. From the data analysis it was found that the STAD type cooperative learning model assisted by Geogebra had a positive effect on students' mathematical communication skills. A discussion of the new findings and research weaknesses is presented as a basic idea for further research).
PENERAPAN RME BERBASIS ICT DALAM MENINGKATKAN KEMAMPUAN BERPIKIR KOMUNIKASI MATEMATIS SISWA DEKADE TERAKHIR: SEBUAH ANALISIS BIBLIOMETRIK
Authors: Zogara Leonard , Daiman Restiana , Rayu Ronaldus , Agul Melania K , Nosi Yuliana V
Published: September 2024

application of the Realistic Mathematics Education (RME) approach supported by Information and Communication Technology (ICT) to improve students' mathematical communication thinking skills in the last decade. Bibliometric analysis will be used to evaluate trends and impact of scientific work on this topic. This research aims to analyze the application of the Realistic Mathematics Education (RME) approach supported by Information and Communication Technology (ICT) in improving students' mathematical communication thinking skills in the last decade. Bibliometric analysis is used to evaluate the trends and impact of scientific works related to this topic. Objective: The aim of this research is to evaluate the contribution of the ICT-based RME approach in improving students' mathematical communication thinking skills in the last decade. In addition, this study also aims to evaluate research trends related to this topic in the last decade. It is hoped that the results of this research can provide useful information for the development of mathematics education in the future.
PENGARUH MODEL PEMBELAJARAN BERBASIS MASALAH BERBANTUAN GEOGEBRA TERHADAP KEMAMPUAN BERPIKIR KRITIS SISWA SMP
Authors: Jemamun Maria Erfiani , Tamur Maximus , Makur Alberta P
Published: September 2024

Penelitian ini bertujuan untuk mendeskripsikan peningkatan kemampuan berpikir kritis siswa yang memperoleh model pembelajaran berbasis masalah (PBL) berbantuan geogebra dan kelompok siswa yang memperoleh pembelajaran konvensional kelas VIII SMP Widya Bhakti Ruteng Tahun Ajaran 2022/2023. Metode eksperimen semu dengan desain posttest only control grup design digunakan untuk menjawab tujuan penelitian. Sampel penelitian untuk kelas eksperimen berjumlah 20 siswa dan kelas kontrol berjumlah 21 siswa. Instrumen yang digunakan adalah tes berbentuk uraian sebanyak lima nomor soal. Data yang diperoleh dalam penelitian ini dianalisis menggunakan uji t dengan menggunakan rumus polled varians. Hasil analisis data penelitian diperoleh kelompok eksperimen mendapatkan nilai rata-rata 73 sedangkan kelompok kontrol mendapatkan nilai rata-rata 65. Hasil uji perbedaan rerata memperlihatkan bahwa kemampuan berpikir kritis siswa yang menggunakan model PBL berbantuan geogebra lebih tinggi dari pada kemampuan berpikir kritis siswa yang menggunakan model pembelajaran konvensional. Hasil ini menunjukkan tren positif dari pembelajaran yang mengkondisikan siswa untuk menyelesaikan masalah dengan bantuan teknologi seperti geogebra. Temuan ini menjadi salah satu rujukan untuk mempertimbangkan penggunaan model PBL berbantuan geogebra pada konsep dan materi matematika SMP lainnya.