bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing
Authors: Mosharaf Md. Parvez , Reza Md. Selim , Kibria Md. Kaderi , Ahmed Fee Faysal , Kabir Md. Hadiul , Hasan Sohel , Mollah Md. Nurul Haque
Published: March 2022

The pandemic threat of COVID-19 has severely destroyed human life as well as the economy around the world. Although, the vaccination has reduced the outspread, but people are still suffering due to the unstable RNA sequence patterns of SARS-CoV-2 which demands supplementary drugs. To explore novel drug target proteins, in this study, a transcriptomics RNA-Seq data generated from SARS-CoV-2 infection and control samples were analyzed. We identified 109 differentially expressed genes (DEGs) that were utilized to identify 10 hub-genes/proteins (TLR2, USP53, GUCY1A2, SNRPD2, NEDD9, IGF2, CXCL2, KLF6, PAG1 and ZFP36) by the protein–protein interaction (PPI) network analysis. The GO functional and KEGG pathway enrichment analyses of hub-DEGs revealed some important functions and signaling pathways that are significantly associated with SARS-CoV-2 infections. The interaction network analysis identified 5 TFs proteins and 6 miRNAs as the key regulators of hub-DEGs. Considering 10 hub-proteins and 5 key TFs-proteins as drug target receptors, we performed their docking analysis with the SARS-CoV-2 3CL protease-guided top listed 90 FDA approved drugs. We found Torin-2, Rapamycin, Radotinib, Ivermectin, Thiostrepton, Tacrolimus and Daclatasvir as the top ranked seven candidate drugs. We investigated their resistance performance against the already published COVID-19 causing top-ranked 11 independent and 8 protonated receptor proteins by molecular docking analysis and found their strong binding affinities, which indicates that the proposed drugs are effective against the state-of-the-arts alternatives independent receptor proteins also. Finally, we investigated the stability of top three drugs (Torin-2, Rapamycin and Radotinib) by using 100 ns MD-based MM-PBSA simulations with the two top-ranked proposed receptors (TLR2, USP53) and independent receptors (IRF7, STAT1), and observed their stable performance. Therefore, the proposed drugs might play a vital role for the treatment against different variants of SARS-CoV-2 infections.
Isotopic signatures and source apportionment of Pb in ambient PM2.5
Authors: Jung Chien-Cheng , Chou Charles C.-K. , Huang Yi-Tang , Chang Shih-Yu , Lee Chung-Te , Lin Chuan-Yao , Cheung Hing-Cho , Kuo Wei-Chen , Chang Chih-Wei , Chang Shuenn-Chin
Published: March 2022

Particulate lead (Pb) is a primary air pollutant that affects society because of its health impacts. This study investigates the source sectors of Pb associated with ambient fine particulate matter (PM2.5) over central-western Taiwan (CWT) with new constraints on the Pb-isotopic composition. We demonstrate that the contribution of coal-fired facilities is overwhelming, which is estimated to reach 35 ± 16% in the summertime and is enhanced to 57 ± 24% during the winter monsoon seasons. Moreover, fossil-fuel vehicles remain a major source of atmospheric Pb, which accounts for 12 ± 5%, despite the current absence of a leaded gasoline supply. Significant seasonal and geographical variations in the Pb-isotopic composition are revealed, which suggest that the impact of East Asian (EA) pollution outflows is important in north CWT and drastically declines toward the south. We estimate the average contribution of EA outflows as accounting for 35 ± 15% (3.6 ± 1.5 ng/m3) of the atmospheric Pb loading in CWT during the winter monsoon seasons.
Mathematical modeling of metal recovery from E-waste using a dark-fermentation-leaching process
Authors: Russo Fabiana , Luongo Vincenzo , Mattei Maria Rosaria , Frunzo Luigi
Published: March 2022

In this work, an original mathematical model for metals leaching from electronic waste in a dark fermentation process is proposed. The kinetic model consists of a system of non-linear ordinary differential equations, accounting for the main biological, chemical, and physical processes occurring in the fermentation of soluble biodegradable substrates and in the dissolution process of metals. Ad-hoc experimental activities were carried out for model calibration purposes, and all experimental data were derived from specific lab-scale tests. The calibration was achieved by varying kinetic and stoichiometric parameters to match the simulation results to experimental data. Cumulative hydrogen production, glucose, organic acids, and leached metal concentrations were obtained from analytical procedures and used for the calibration. The results confirmed the high accuracy of the model in describing biohydrogen production, organic acids accumulation, and metals leaching during the biological degradation process. Thus, the mathematical model represents a useful and reliable tool for the design of strategies for valuable metals recovery from waste or mineral materials. Moreover, further numerical simulations were carried out to analyze the interactions between the fermentation and the leaching processes and to maximize the efficiency of metals recovery due to the fermentation by-products.
Micro-Fourier-transform infrared reflectance spectroscopy as tool for probing IgG glycosylation in COVID-19 patients
Authors: Bandeira Carla Carolina Silva , Madureira Karen Cristina Rolim , Rossi Meire Bocoli , Gallo Juliana Failde , da Silva Ana Paula Marques Aguirra , Torres Vilanilse Lopes , de Lima Vinicius Alves , Júnior Norival Kesper , Almeida Janete Dias , Zerbinati Rodrigo Melim , Braz-Silva Paulo Henrique , Lindoso José Angelo Lauletta , da Silva Martinho Herculano
Published: March 2022

It has been reported that patients diagnosed with COVID-19 become critically ill primarily around the time of activation of the adaptive immune response. However the role of antibodies in the worsening of disease is not obvious. Higher titers of anti-spike immunoglobulin IgG1 associated with low fucosylation of the antibody Fc tail have been associated to excessive inflammatory response. In contrast it has been also reported that NP-, S-, RBD- specific IgA, IgG, and IgM are not associated with SARS-CoV-2 viral load, indicating that there is no obvious correlation between antibody response and viral antigen detection. In the present work the micro-Fourier-transform infrared reflectance spectroscopy (micro-FTIR) was employed to investigate blood serum samples of healthy and COVID-19-ill (mild or oligosymptomatic) individuals (82 healthcare workers volunteers in “Instituto de Infectologia Emilio Ribas”, São Paulo, Brazil). The molecular-level-sensitive, multiplexing quantitative and qualitative FTIR data probed on 1 µL of dried biofluid was compared to signal-to-cutoff index of chemiluminescent immunoassays CLIA and ELISA (IgG antibodies against SARS-CoV-2). Our main result indicated that 1702–1785 $$\hbox {cm}^{-1}$$

cm

-
1

spectral window (carbonyl C=O vibration) is a spectral marker of the degree of IgG glycosylation, allowing to probe distinctive sub-populations of COVID-19 patients, depending on their degree of severity. The specificity was 87.5 % while the detection rate of true positive was 100%. The computed area under the receiver operating curve was equivalent to CLIA, ELISA and other ATR-FTIR methods ($$>0.85$$

>
0.85

). In summary, overall discrimination of healthy and COVID-19 individuals and severity prediction as well could be potentially implemented using micro-FTIR reflectance spectroscopy on blood serum samples. Considering the minimal and reagent-free sample preparation procedures combined to fast (few minutes) outcome of FTIR we can state that this technology is suitable for fast screening of immune response of individuals with COVID-19. It would be an important tool in prospective studies, helping investigate the physiology of the asymptomatic, oligosymptomatic, or severe individuals and measure the extension of infection dissemination in patients.
Numerical analysis of Casson nanofluid three-dimensional flow over a rotating frame exposed to a prescribed heat flux with viscous heating
Authors: Al-Kouz Wael , Owhaib Wahib
Published: March 2022

This study investigates heat transfer characteristics and three-dimensional flow of non-Newtonian Casson nanofluid over a linearly stretching flat surface in the rotating frame of a reference. The current model includes the Buongiorno nanofluid model comprises nanoparticles’ haphazard motion and thermo-migration. It also considered mechanisms for viscous heating and constant heat flux at the boundary. The nonlinear partial differential system modeling includes the non-Newtonian Casson fluid model and the boundary layer approximation. The system governing equations were nondimensionalized and numerically solved. A parametric study was conducted to analyze the significance of dimensionless parameters on velocities, the concentration, temperatures, Nusselt number, friction factors, and Sherwood number. The study reveals that the Casson nanoliquid temperature enhanced significantly due to the mechanisms of haphazard motion and thermo-migration. The momentum layer thickness of nano Casson fluid reduced due to the rotation phenomenon while the thermal layer structure amended notably. In the absence of rotation, there is no transverse velocity. The thermal layer structure is enhanced owing to the viscous heating process. The intense haphazard motion and thermo-migration mechanisms lead to maximum heat transfer rate at the plate. In addition, results show that the Coriolis force strength elevation shows similar axial and transverse velocities behavior. In addition, the nanoparticle concentration is observed higher due to the rotation aspect and Casson fluid parameter. Furthermore, the Casson fluid factor decreases with velocities, but the trend is the opposite for the high Casson fluid factor. The thermal and solute layer thickness growth is due to the nanoparticles’ thermo-diffusion. In conclusion, the larger rotation factor increases the friction factors. The maximum plate heat transfer rate is when higher Nb and Nt are higher.
Immune-related lincRNA pairs predict prognosis and therapeutic response in hepatocellular carcinoma
Authors: Zhang Yingna , Yang Xiaofeng , Zhou Lisha , Gao Xiangting , Wu Xiangwei , Chen Xueling , Hou Jun , Wang Lianghai
Published: March 2022

Growing evidence has demonstrated the functional relevance of long intergenic noncoding RNAs (lincRNAs) to tumorigenesis and immune response. However, immune-related lincRNAs and their value in predicting the clinical outcomes of patients with liver cancer remain largely unexplored. Herein, we utilized the strategy of iterative gene pairing to construct a tumor-specific immune-related lincRNA pairs signature (IRLPS), which did not require specific expression levels, as an indicator of patient outcomes. The 18-IRLPS we developed was associated with overall survival, tumor progression, and recurrence in liver cancer patients. Multivariate analysis revealed that the risk model was an independent predictive factor. A high IRLPS risk was correlated suppressive immune microenvironment, and IRLPS-high patients might benefit more from CD276 blockade or TMIGD2 agonist. Patients in the high-risk group were associated with elevated tumor mutation, increased sensitivity to dopamine receptor antagonists, cisplatin, doxorubicin, and mitomycin but more resistance to vinblastine. Mechanistically, IRLPS high scores might lead to poor prognosis by promoting cell proliferation and metabolic reprogramming. The prognostic significance of the 18-IRLPS was confirmed in independent cancer datasets. These findings highlighted the robust predictive performances of the 18-IRLPS for prognosis and personalized treatment.
Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish
Authors: Kawano Kohei , Kato Kagayaki , Sugioka Takumi , Kimura Yukiko , Tanimoto Masashi , Higashijima Shin-ichi
Published: March 2022

Developmental maturation occurs in slow swimming behavior in larval zebrafish; older larvae acquire the ability to perform slow swimming while keeping their head stable in the yaw dimension. A class of long-distance descending commissural excitatory V0v neurons, called MCoD neurons, are known to develop in a later phase of neurogenesis, and participate in slow swimming in older larvae. We hypothesized that these MCoD neurons play a role in coordinating the activities of trunk muscles in the diagonal dimension (e.g., the rostral left and the caudal right) to produce the S-shaped swimming form that contributes to the stability of the head. Here, we show that MCoD neurons do indeed play this role. In larvae in which MCoD neurons were laser-ablated, the swimming body form often adopted a one-sided (C-shaped) bend with reduced appearance of the normal S-shaped bend. With this change in swimming form, the MCoD-ablated larvae exhibited a greater degree of head yaw displacement during slow swimming. In mice, the long-distance descending commissural V0v neurons have been implicated in diagonal interlimb coordination during walking. Together with this, our study suggests that the long-distance descending commissural V0v neurons form an evolutionarily conserved pathway in the spinal locomotor circuits that coordinates the movements of the diagonal body/limb muscles.
Microengineered filters for efficient delivery of nanomaterials into mammalian cells
Authors: Morshedi Rad Dorsa , Rezaei Meysam , Radfar Payar , Ebrahimi Warkiani Majid
Published: March 2022

Intracellular delivery of nanomaterials into the cells of interest has enabled cell manipulation for numerous applications ranging from cell-based therapies to biomedical research. To date, different carriers or membrane poration-based techniques have been developed to load nanomaterials to the cell interior. These biotools have shown promise to surpass the membrane barrier and provide access to the intracellular space followed by passive diffusion of exogenous cargoes. However, most of them suffer from inconsistent delivery, cytotoxicity, and expensive protocols, somewhat limiting their utility in a variety of delivery applications. Here, by leveraging the benefits of microengineered porous membranes with a suitable porosity, we demonstrated an efficient intracellular loading of diverse nanomaterials to different cell types based on inducing mechanical disruption to the cell membrane. In this work, for the first time, we used ultra-thin silicon nitride (SiN) filter membranes with uniform micropores smaller than the cell diameter to load impermeable nanomaterials into adherent and non-adherent cell types. The delivery performance using SiN microsieves has been validated through the loading of functional nanomaterials from a few nanometers to hundreds of nanometers into mammalian cells with minimal undesired impacts. Besides the high delivery efficiency and improved cell viability, this simple and low-cost approach offers less clogging and higher throughput (107 cell min−1). Therefore, it yields to the efficient introduction of exogenous nanomaterials into the large population of cells, illustrating the potential of these microengineered filters to be widely used in the microfiltroporation (MFP) setup.
Mid-infrared photon sensing using InGaN/GaN nanodisks via intersubband absorption
Authors: Xing Zhang , Akter Afroja , Kum Hyun S. , Baek Yongmin , Ra Yong-Ho , Yoo Geonwook , Lee Kyusang , Mi Zetian , Heo Junseok
Published: March 2022

Intersubband (intraband) transitions allow absorption of photons in the infrared spectral regime, which is essential for IR-photodetector and optical communication applications. Among various technologies, nanodisks embedded in nanowires offer a unique opportunity to be utilized in intraband devices due to the ease of tuning the fundamental parameters such as strain distribution, band energy, and confinement of the active region. Here, we show the transverse electric polarized intraband absorption using InGaN/GaN nanodisks cladded by AlGaN. Fourier transform infrared reflection (FTIR) measurement confirms absorption of normal incident in-plane transverse electric polarized photons in the mid-IR regime (wavelength of ~ 15 μm) at room temperature. The momentum matrix of the nanodisk energy states indicates electron transition from the ground state s into the px or py orbital-like excited states. Furthermore, the absorption characteristics depending on the indium composition and nanowire diameter exhibits tunability of the intraband absorption spectra within the nanodisks. We believe nanodisks embedded nanowires is a promising technology for achieving tunable detection of photons in the IR spectrum.
CTSB is a negative prognostic biomarker and therapeutic target associated with immune cells infiltration and immunosuppression in gliomas
Authors: Ma Kaiming , Chen Xin , Liu Weihai , Chen Suhua , Yang Chenlong , Yang Jun
Published: March 2022

Previous researches have demonstrated the meaning of CTSB for the progress of several tumors, whereas few clues about its immunological characteristic in gliomas. Here we systematically explored its biologic features and clinical significance for gliomas. 699 glioma cases of TCGA and 325 glioma cases of CGGA were respectively included as training and validating cohorts. R software was used for data analysis and mapping. We found that CTSB was remarkably highly-expressed for HGG, IDH wild type, 1p19q non-codeletion type, MGMT promoter unmethylation type and mesenchymal gliomas. CTSB could specifically and sensitively indicate mesenchymal glioma. Upregulated CTSB was an independent hazard correlated with poor survival. CTSB-related biological processes in gliomas chiefly concentrated on immunoreaction and inflammation response. Then we proved that CTSB positively related to most inflammatory metagenes except IgG, including HCK, LCK, MHC II, STAT1 and IFN. More importantly, the levels of glioma-infiltrating immune cells were positively associated with the expression of CTSB, especially for TAMs, MDSCs and Tregs. In conclusion, CTSB is closely related to the malignant pathological subtypes, worse prognosis, immune cells infiltration and immunosuppression of gliomas, which make it a promising biomarker and potential target in the diagnosis, treatment and prognostic assessment of gliomas.
Determinants of emergency presentation in patients with colorectal cancer: a systematic review and meta-analysis
Authors: Golder Allan M. , McMillan Donald C. , Horgan Paul G. , Roxburgh Campbell S. D.
Published: March 2022

Colorectal cancer remains a significant cause of morbidity and mortality, even despite curative treatment. A significant proportion of patients present emergently and have poorer outcomes compared to elective presentations, independent of TNM stage. In this systematic review and meta-analysis, differences between elective/emergency presentations of colorectal cancer were examined to determine which factors were associated with emergency presentation. A literature search was carried out from 1990 to 2018 comparing elective and emergency presentations of colon and/or rectal cancer. All reported clinicopathological variables were extracted from identified studies. Variables were analysed through either systematic review or, if appropriate, meta-analysis. This study identified multiple differences between elective and emergency presentations of colorectal cancer. On meta-analysis, emergency presentations were associated with more advanced tumour stage, both overall (OR 2.05) and T/N/M/ subclassification (OR 2.56/1.59/1.75), more: lymphovascular invasion (OR 1.76), vascular invasion (OR 1.92), perineural invasion (OR 1.89), and ASA (OR 1.83). Emergencies were more likely to be of ethnic minority (OR 1.58). There are multiple tumour/host factors that differ between elective and emergency presentations of colorectal cancer. Further work is required to determine which of these factors are independently associated with emergency presentation and subsequently which factors have the most significant effect on outcomes.
Impact of polygenic risk communication: an observational mobile application-based coronary artery disease study
Authors: Muse Evan D. , Chen Shang-Fu , Liu Shuchen , Fernandez Brianna , Schrader Brian , Molparia Bhuvan , León André Nicolás , Lee Raymond , Pubbi Neha , Mejia Nolan , Ren Christina , El-kalliny Ahmed , Prado Montes de Oca Ernesto , Aguilar Hector , Ghoshal Arjun , Dias Raquel , Evans Doug , Chen Kai-Yu , Zhang Yunyue , Wineinger Nathan E. , Spencer Emily G. , Topol Eric J. , Torkamani Ali
Published: March 2022

We developed a smartphone application, MyGeneRank, to conduct a prospective observational cohort study (NCT03277365) involving the automated generation, communication, and electronic capture of response to a polygenic risk score (PRS) for coronary artery disease (CAD). Adults with a smartphone and an existing 23andMe genetic profiling self-referred to the study. We evaluated self-reported actions taken in response to personal CAD PRS information, with special interest in the initiation of lipid-lowering therapy. 19% (721/3,800) of participants provided complete responses for baseline and follow-up use of lipid-lowering therapy. 20% (n = 19/95) of high CAD PRS vs 7.9% (n = 8/101) of low CAD PRS participants initiated lipid-lowering therapy at follow-up (p-value = 0.002). Both the initiation of statin and non-statin lipid-lowering therapy was associated with degree of CAD PRS: 15.2% (n = 14/92) vs 6.0% (n = 6/100) for statins (p-value = 0.018) and 6.8% (n = 8/118) vs 1.6% (n = 2/123) for non-statins (p-value = 0.022) in high vs low CAD PRS, respectively. High CAD PRS was also associated with earlier initiation of lipid lowering therapy (average age of 52 vs 65 years in high vs low CAD PRS respectively, p-value = 0.007). Overall, degree of CAD PRS was associated with use of any lipid-lowering therapy at follow-up: 42.4% (n = 56/132) vs 28.5% (n = 37/130) (p-value = 0.009). We find that digital communication of personal CAD PRS information is associated with increased and earlier lipid-lowering initiation in individuals of high CAD PRS. Loss to follow-up is the primary limitation of this study. Alternative communication routes, and long-term studies with EHR-based outcomes are needed to understand the generalizability and durability of this finding.
The volcanic relationship between the HER activity and lattice constant of RuCo alloy nanofilms
Authors: Wang Yanyan , Ren Zhandong , Cong Ning , Heng Yaping , Wang Ming , Wang Ziqian , Xie Zhiqiang , Liu Ye , Han Juanjuan , Zhu Yuchan
Published: March 2022

There is a volcanic relationship between the outstanding HER activity and the lattice constant of RuCo alloy nanofilms (RuCo-ANFs) with different ratios in 1.0 M KOH.
Improved highly efficient Dion–Jacobson type perovskite light-emitting diodes by effective surface polarization architecture
Authors: Yang Hanjun , Tang Jun , Deng Liangliang , Liu Zhe , Yang Xia , Huang Zengqi , Yu Haomiao , Wang Kai , Li Jinpeng
Published: March 2022

An effective polarized interface is built by combining the excessive-salt-assisted and antisolvent methods. This cooperation can decrease the trap density and hole injection barrier for high performance DJ-type perovskite light-emitting diodes.
Nanoscale chemical characterization of biomolecules using tip-enhanced Raman spectroscopy
Authors: Bonhommeau Sébastien , Cooney Gary S. , Huang Yuhan
Published: March 2022

This tutorial review describes the fundamental and technical aspects of tip-enhanced Raman spectroscopy as well as chemical and structural information provided by this technique to characterize biomolecules with nanoscale spatial resolution.
Partial reduction of NO to N2O on Cu{311}: role of intermediate N2O2
Authors: Sitathani Krit , Jenkins Stephen J. , Temprano Israel
Published: March 2022

Reflection absorption infrared spectroscopy (RAIRS) and first-principles density functional theory (DFT) combine to suggest a pathway for NOx reduction on Cu{311} involving a flat-lying N2O2 intermediate.
Kinetic studies on Lewis acidic metal polyesterification catalysts – hydrolytic degradation is a key factor for catalytic performance
Authors: Wolzak Lukas A. , van Gemert Rogier , van den Berg Keimpe J. , Reek Joost N. H. , Tromp Moniek , Korstanje Ties J.
Published: March 2022

Kinetic studies of Lewis acidic metal-catalyzed polyesterification reactions unveiled that titanium-based catalyst are prone to hydrolytic degradation, while n-BuSnOOH proved to be a robust catalyst.
To form or not to form: PuO2 nanoparticles at acidic pH
Authors: Gerber Evgeny , Romanchuk Anna Yu. , Weiss Stephan , Kuzenkova Anastasiia , Hunault Myrtille O. J. Y. , Bauters Stephen , Egorov Alexander , Butorin Sergei M. , Kalmykov Stepan N. , Kvashnina Kristina O.
Published: March 2022

The combination of advanced spectroscopic and microscopic methods used in this work enables molecular and atomic levels understanding of the Pu(iv) nanoparticles formation under acidic conditions (pH 1–4).
A light-switch for efficient decolorization of azo dye wastewater based on bacteria–semiconductor interaction
Authors: Du Yimei , Guo Jianbo , Hou Ya-Nan , Song Yuanyuan , Lu Caicai , Han Yi , Li Haibo
Published: March 2022

This study investigated the interaction of Shewanella oneidensis MR-1 and CdS in azo dye decolorization, showing that CdS could act as a light-switch to achieve fast light-driven decolorization.
Structure and activity study of tripeptide IRW in TNF-α induced insulin resistant skeletal muscle cells
Authors: Jiang Xu , Wu Jianping
Published: March 2022

IRW was found to improve TNF-α induced insulin resistance. IRW analog IRA and derivative IR reversed the increased tyrosine residue of IRS and decreased serine residue of IRS induced by TNF-α. Thus, IRW, IR and IRA improved the GLUT4 translocation.
Carnosic acid ameliorated Aβ-mediated (amyloid-β peptide) toxicity, cholinergic dysfunction and mitochondrial defect in Caenorhabditis elegans of Alzheimer's Model
Authors: Chen Yun , Wang Yarong , Qin Qiao , Zhang Yali , Xie Lingling , Xiao Jie , Cao Yong , Su Zuanxian , Chen Yunjiao
Published: March 2022

Carnosic acid reduced Aβ deposition and Aβ-mediated neurotoxicity, and ameliorated cholinergic dysfunction and mitochondrial disorders in the C. elegans model of Alzheimer's disease.
Ethnicity impact on oral processing behaviour and glycemic response to noodles: Chinese (Asian) vs. New Zealander (Caucasian)
Authors: Jin Xiaoxuan , Lin Suyun , Gao Jing , Kim Esther H.-J. , Morgenstern Marco P. , Wilson Arran J. , Agarwal Deepa , Wadamori Yukiko , Wang Yong , Ying Jian , Dong Zhizhong , Zhou Weibiao , Song Xiaoming , Zhao Qian
Published: March 2022

Results of this study confirmed the significance of oral processing in determining food digestion, and provide new insights on the role of ethnicity in influencing people's physiological response to food.
Elderly gastrointestinal conditions increase sterol bioaccessibility in a plant sterol-enriched beverage: adaptation of the INFOGEST method
Authors: Miedes Diego , Makran Mussa , Barberá Reyes , Cilla Antonio , Alegría Amparo , Garcia-Llatas Guadalupe
Published: March 2022

Elderly people suffer from a higher cardiovascular risk.
Visible-light-induced metal-free coupling of C(sp3)–H sources with heteroarenes
Authors: Ghosh Anogh , Pyne Pranjal , Ghosh Sumit , Ghosh Debashis , Majumder Souvik , Hajra Alakananda
Published: March 2022

This critical review chronologically summarizes the metal-free coupling methodologies of C(sp3)–H sources with heteroarenes induced by visible light. The articles which are published up to January 2022 on this topic are enclosed here.
Transition metal-free selective C–S bond cleavage of Ugi-adducts for rapid preparation of peptidomimetics
Authors: Liu Chao , Song Liangliang , Peshkov Vsevolod A. , Van der Eycken Erik V.
Published: March 2022

Diverse peptidomimetics containing N,O- or N,S-aminals are synthesized via a transition metal-free C–S bond cleavage and subsequent Mannich reaction.
The base-catalyzed aerobic oxidation of hydroquinones to benzoquinones under metal-free conditions
Authors: Luo Jianwei , Yao Jia , Li Haoran
Published: March 2022

The metal-free synthesis of benzoquinones was developed through the aerobic oxidation of hydroquinones catalyzed by an inexpensive base.
Recent advances in microfluidic devices for single-cell cultivation: methods and applications
Authors: Anggraini Dian , Ota Nobutoshi , Shen Yigang , Tang Tao , Tanaka Yo , Hosokawa Yoichiroh , Li Ming , Yalikun Yaxiaer
Published: March 2022

Single-cell cultivation is essential to investigate the actual cellular and subcellular information of individual cells and enhance single-cell colonies and cell-derived products for further analysis at a single-cell level.
ZnO/ZnFe2O4 nanocomposite-based electrochemical nanosensors for the detection of furazolidone in pork and shrimp samples: exploring the role of crystallinity, phase ratio, and heterojunction formation
Authors: Anh Nguyen Tuan , Huyen Nguyen Ngoc , Dinh Ngo Xuan , Vinh Le Khanh , Tung Le Minh , Vinh Nguyen Thanh , Quy Nguyen Van , Lam Vu Dinh , Le Anh-Tuan
Published: March 2022

The effect of crystallinity, phase ratio, and heterojunction formation on the FZD sensing performance of ZnO/ZnFe2O4 nanocomposite-based electrochemical sensors was investigated.
Structural and ethylene oligomerization studies of chelating (imino)phenol Fe(ii), Co(ii) and Ni(ii) complexes: an experimental and theoretical approach
Authors: Ngcobo Makhosonke , Nose Holliness , Jayamani Arumugam , Ojwach Stephen O.
Published: March 2022

Experimental and theoretical data indicate that the stability and metal charge of N^O Fe(ii), Co(ii) and Ni(ii) complexes control their catalytic activities in ethylene oligomerization reactions.
3-Vinyl oxindole-chromone synthon as a skeletal reconstruction reactant for the synthesis of 2-hydroxy benzoyl pyridones
Authors: Zhang Lei , Liu Ren-Ming , Wang Wei-Na , Liu Xiong-Li , Dai Yi-Feng , Yu Zhang-Biao , Peng Li-Jun
Published: March 2022

The first example of 3-vinyl oxindole-chromones in the ring opening and recyclization reaction.
Syntheses of new zeolitic imidazolate frameworks in dimethyl sulfoxide
Authors: Guo Shen , Li Hui-Zi , Wang Zhi-Wen , Zhu Zi-Yi , Zhang Shu-Hua , Wang Fei , Zhang Jian
Published: March 2022

Presented here are the syntheses of a series of ZIFs with various topologies such as ACO, coi, zni, ANA, and GIS, and even a new topology in DMSO, suggesting that DMSO is a powerful medium for the syntheses of ZIFs.
Electrocatalytic hydrogen generation using tripod containing pyrazolylborate-based copper(ii), nickel(ii), and iron(iii) complexes loaded on a glassy carbon electrode
Authors: Ibrahim Mohamed M. , Mersal G. A. M. , Fallatah Ahmed M. , Althubeiti Khaled , El-Sheshtawy Hamdy S. , Abou Taleb Manal F. , Das Manash R. , Boukherroub Rabah , Attia Mohamed S. , Amin Mohammed A.
Published: March 2022

Three transition metal complexes (MC) namely, [TpMeMeCuCl(H2O)] (CuC), [TpMeMeNiCl] (NiC), and [TpMeMeFeCl2(H2O)] (FeC) {TpMeMe= tris(3,5-dimethylpyrazolyl)borate} were synthesized and structurally characterized.
Hierarchically porous doped carbons fabricated by the strategy of ion transfer coordination (ITC)
Authors: Xu Zhi , Li Le , Fang Chenhong , Zhang Linjuan , Xiao Guyu
Published: March 2022

The ion-transfer coordination (ITC) strategy is designed to prepare hierarchical porous carbons for diffusion-limited applications.
Less is more: tiny amounts of insoluble multi-functional nanoporous additives play a big role in lithium secondary batteries
Authors: Qi Ruoxuan , Yang Chao , Ma Liujia , Fan Xiaoying , Wu Qiaoyun , Wang Chao , Cheng Ya-Jun , Guo Kunkun , Gao Yanfeng , Xia Yonggao
Published: March 2022

A new concept of electrode processing with tiny amounts of multi-functional microporous PIM additives was established as an alternative to binder-containing and binder-free electrodes, leading to enhanced electrochemical performance.
Electrochemical genosensor based on gold nanostars for the detection of Escherichia coli O157:H7 DNA
Authors: Razmi Nasrin , Hasanzadeh Mohammad , Willander Magnus , Nur Omer
Published: March 2022

Electrochemical genosensor based on gold nanostars for E. coli O157:H7 detection constructed. Application of GNSs along with SWV technique provided a fast response for DNA detection of E. coli O157:H7 with a low limit of quantification of 0.01 zM.
A minimalist fluorescent MOF sensor array for Baijiu identification
Authors: Liu Xiaofang , Zhang Jing , Ma Yi , Zhao Dong , Huo Danqun , Luo Huibo , Li Jiawei , Luo Xiaogang , Hou Changjun
Published: March 2022

We report a minimalist fluorescent metal–organic framework (MOF) sensor array for Baijiu identification. The original MOF was modified by rare-earth elements to obtain Eu-MOFs and Tb-MOFs exhibiting multiple fluorescence peaks in the range of 400–700 nm.
Visible light-promoted synthesis of ureas and formamides from amines and CO2
Authors: Zhang Qian , Hou Jing , Huang Yan , Zhan Le-wu , Li Bin-dong
Published: March 2022

A divergent visible-light-induced Ph3P-promoted method for the synthesis of ureas and formamides from amines and CO2 has been developed. A range of ureas could be accessed under ambient temperature and pressure. Formamides could be also produced.
Synthesis of α-keto aldehydes via selective Cu(i)-catalyzed oxidation of α-hydroxy ketones
Authors: Zheng Shasha , Smit Wietse , Spannenberg Anke , Tin Sergey , de Vries Johannes G.
Published: March 2022

A practical Cu(i)-catalyzed selective oxidation of α-hydroxyketones for the syntheses of α-keto aldehydes has been developed.
Spectroscopic characterization of two boron heterocyclic radicals in the solid neon matrix
Authors: Xu Jiaping , Xu Xin , Li Danyang , Jian Jiwen
Published: March 2022

Boron heterocyclic radicals: spectroscopic evidence of forming a six-membered ring 3,4,5-trihydroborinine radical and a five-membered ring 1-methyl-2-dihydro-1H-borole radical in solid neon has been presented. Atom colors: B = pink; C = gray; and H = white.
Targeting gut microbiota-derived butyrate improves hepatic gluconeogenesis through the cAMP-PKA-GCN5 pathway in late pregnant sows
Authors: Qin Longshan , Yao Weilei , Wang Tongxin , Jin Taimin , Guo Baoyin , Wen Shu , Huang Feiruo
Published: March 2022

Butyrate produced by gut microbiota affected hepatic glucose metabolismviathe gut–liver axis.
Tracking the concentration of Al3+ in the aqueous system up to the nanomolar range using a modified biopolymer chitosan based fluorophore
Authors: Garg Madhvi , Sud Dhiraj
Published: March 2022

A simple and facile synthesis of a biopolymer chitosan based fluorophore for selective detection of Al3+ in the aqueous system up to nanomolar concentration.
Green synthetic nitrogen-doped graphene quantum dot fluorescent probe for the highly sensitive and selective detection of tetracycline in food samples
Authors: Xie Huanyu , Lu Yudong , You Ruiyun , Qian Wei , Lin Shan
Published: March 2022

Tetracycline (TC) is a broad-spectrum antibiotic.
Continuous flow Meerwein–Ponndorf–Verley reduction of HMF and furfural using basic zirconium carbonate
Authors: Marçon Henrique Magri , Pastre Julio Cezar
Published: March 2022

Reduction of furfural and HMF in a continuous flow regime mediated by basic zirconium carbonate using 2-propanol as a solvent and reducing agent towards the synthesis of platform chemicals is presented.
Lanthanide-mediated tuning of electronic and magnetic properties in heterotrimetallic cyclooctatetraenyl multidecker self-assemblies
Authors: Zhou Zheng , McNeely James , Greenough Joshua , Wei Zheng , Han Haixiang , Rouzières Mathieu , Rogachev Andrey Yu. , Clérac Rodolphe , Petrukhina Marina A.
Published: March 2022

A new class of heterotrimetallic COT-based self-assemblies accommodates metals from groups I–III in three different oxidation states and enables tuning of electronic and magnetic properties.
Probing star formation and ISM properties using galaxy disk inclination
Authors: van der Giessen S. A. , Leslie S. K. , Groves B. , Hodge J. A. , Popescu C. C. , Sargent M. T. , Schinnerer E. , Tuffs R. J.
Published: March 2022

Attenuation by dust severely impacts our ability to obtain unbiased observations of galaxies, especially as the amount and wavelength dependence of the attenuation varies with the stellar mass M*, inclination i, and other galaxy properties. In this study, we used the attenuation – inclination models in ultraviolet, optical, and near-infrared bands designed by Tuffs and collaborators to investigate the average global dust properties in galaxies as a function of M*, the stellar mass surface density μ*, the star-formation rate SFR, the specific star-formation rate sSFR, the star-formation main-sequence offset dMS, and the star-formation rate surface density ΣSFR at redshifts z ∼ 0 and z ∼ 0.7. We used star-forming galaxies from the Sloan Digital Sky Survey (∼20 000) and Galaxy And Mass Assembly (∼2000) to form our low-z sample at 0.04 < z < 0.1 and star-forming galaxies from Cosmological Evolution Survey (∼2000) for the sample at 0.6 < z < 0.8. We found that galaxies at z ∼ 0.7 have a higher optical depth τBf and clumpiness F than galaxies at z ∼ 0. The increase in F hints that the stars of z ∼ 0.7 galaxies are less likely to escape their birth cloud, which might indicate that the birth clouds are larger. We also found that τBf increases with M* and μ*, independent of the sample and therefore redshift. We found no clear trends in τBf or F with the SFR, which could imply that the dust mass distribution is independent of the SFR. In turn, this would imply that the balance of dust formation and destruction is independent of the SFR. Based on an analysis of the inclination dependence of the Balmer decrement, we found that reproducing the Balmer line emission requires not only a completely optically thick dust component associated with star-forming regions, as in the standard model, but an extra component of an optically thin dust within the birth clouds. This new component implies the existence of dust inside H II regions that attenuates the Balmer emission before it escapes through gaps in the birth cloud and we found it is more important in high-mass galaxies. These results will inform our understanding of dust formation and dust geometry in star-forming galaxies across redshift.
An empirical nonlinear power spectrum overdensity response
Authors: Rácz Gábor , Szapudi István , Csabai István
Published: March 2022

Context.The overdensity inside a cosmological sub-volume and the tidal fields from its surroundings affect the matter distribution of the region. The resulting difference between the local and global power spectra is characterized by the response function.

Aims.Our aim is to provide a new, simple, and accurate formula for the power spectrum overdensity response at highly nonlinear scales based on the results of cosmological simulations and paying special attention to the lognormal nature of the density field.

Methods.We measured the dark matter power spectrum amplitude as a function of the overdensity (δW) inN-body simulation subsamples. We show that the response follows a power-law form in terms of (1 + δW), and we provide a new fit in terms of the variance,σ(L), of a sub-volume of sizeL.

Results.Our fit has a similar accuracy and a comparable complexity to second-order standard perturbation theory on large scales, but it is also valid for nonlinear (smaller) scales, where perturbation theory needs higher-order terms for a comparable precision. Furthermore, we show that the lognormal nature of the overdensity distribution causes a previously unidentified bias: the power spectrum amplitude for a subsample with an average density is typically underestimated by about −2σ2. Although this bias falls to the sub-percent level above characteristic scales of 200 Mpc h−1, taking it into account improves the accuracy of estimating power spectra from zoom-in simulations and smaller high-resolution surveys embedded in larger low-resolution volumes.
Growth of size-matched nanoalloys – a comparison of AuAg and PtPd
Authors: El koraychy El yakout , Nelli Diana , Roncaglia Cesare , Minnai Chloé , Ferrando Riccardo
Published: March 2022

The gas-phase growth of AuAg and PtPd clusters up to sizes ~3 nm is simulated by Molecular Dynamics. Both systems are characterized by a very small size mismatch and by a tendency of the less cohesive element to segregate at the nanoparticle surface. The aim of this work is to figure out the differences in the behavior between these two bimetallic systems at the atomic level. For each system, three simulation types are performed, in which either one species or both species are deposited on preformed bimetallic seeds. Our results show that core@shell and intermixed chemical ordering arrangements can be obtained, in agreement with the available experimental data. In the case of core@shell arrangement, the purity of the surface layer is perfect for Ag-rich and Pd-rich nanoparticles, whereas in Au-rich and Pt-rich ones, some tendency to surface migration of minority atoms (Ag or Pd) is observed. This tendency is somewhat stronger for Ag than for Pd. The analysis of the internal arrangement of the nanoparticles indicates that in the growth process the mobility of Pd and Ag minority atoms is stronger than that of Au and Pt minority atoms.
Expert System for Early Detection and Diagnosis of Central Nervous Diseases in Humans with Forward Chaining and Backward Chaining Methods Using Interactive Multimedia
Authors: Paryati  , Krit Salahddine
Published: March 2022

The tasks of the nervous system contained in the human body include diagnosing, analyzing and conveying information. This information that has been obtained will be combined with the sensory system, and will then be integrated in the brain and signals, then transmitted again to the motor system and autonomic pathways to control movement, visceral activity, and endocrine function. All actions are controlled by nerves which are interconnected to form a signaling network consisting of the sensory system and the motor system. The nervous system has several functions, including immunity and supporting function and modulating the activity of the nervous system. There are many types of neurological diseases found in the medical world, but due to a lack of information and knowledge about the disease. So the researchers made this study using forward and backward chaining reasoning methods, along with neurological disease therapy, ways of healing, and methods of treatment. This system is made so that sufferers can easily understand about neurological diseases, and understand the types of central nervous diseases, along with their healing therapies, and how to treat them. This system provides several solutions to prevent neurological diseases according to the type of disease. The system development methodology uses the waterfall method. Application software used to create this application program is Dreamweaver MX, Adobe Flash CS3, XAMPP, Adobe Photoshop, MySQL, Opera, Mozilla Firefox. The result of this research is an application program that can help users to find out the types of central nervous disease and provide extensive information about central nervous disease and find out how to treat and cure them.
Research on energy consumption quota of metrology laboratory
Authors: Dong Zeyu , Wang Hongjun , Dong Yuping , Liu Yang , Liu Yan
Published: March 2022

The research on energy consumption quota of metrology laboratory is an important part of building energy conservation from the perspective of total amount control. Through the research on the investigation method of basic energy consumption data, the type of quota index and the determination method of quota level. The analysis shows that the metrology laboratory adopts the method of unequal proportion classified sampling survey to obtain the basic data of energy consumption, adopts the energy consumption per unit area, considers the correction of energy consumption time and the proportion of auxiliary room area as the quota index, and uses the quota level method to determine the limit value, reference value and advanced value of energy consumption quota, which is fair, scientific and feasible.
Effective mechanism of BaO on the structure and fluid behavior of CaO-SiO2-B2O3-based melts
Authors: Sadaf Shama , Lei Jie , Zhuang Hai-xiang , Wu Ting , Wang Hai-chuan
Published: March 2022

The influence of BaO contents on structure and fluid behavior of fluorine-free CaO-SiO2-B2O3 based melts were examined using molecular dynamic (MD) simulation, rotary viscometer, X-ray diffraction and Fourier transform infrared spectroscopy. The FTIR results matched well with the MD simulation results that with the addition of BaO contents in CaO-SiO2-B2O3 based melts, more cations were provided to balance the negative charge of [BO4]5– tetrahedrons, leading to the structures of Si-O and B-O were more aggregated and the adjacent structural units were more closely connected, which made the structure complex, so the viscosity of mold fluxes at high temperature in the basicity range 1.15–1.25 was intensify. Meanwhile, when BaO replaced CaO under distinctive basic conditions, the viscous activity of fluorine-free mold flux was decreasing generally, showing that as the temperature was decreased, the tendency of slag to converge into complex network structural units was also decreasing, which states the improvement of lubrication capacity of the slag during cooling process.
Allons-nous vers une société plus responsable grâce à la pandémie de Covid-19 ?
Authors: Trespeuch Léo , Robinot Élisabeth , Botti Laurent , Bousquet Julien , Corne Aurélie , De Ferran Florence , Durif Fabien , Ertz Myriam , Fontan Jean-Marc , Giannelloni Jean-Luc , Hallegatte Damien , Kreziak Dominique , Lalancette Mireille , Lajante Mathieu , Michel Hélène , Parguel Béatrice , Peypoch Nicolas
Published: March 2022

La question traitée dans cet article porte sur le monde d’après la pandémie… Représente-t-elle un moment décisif qui va nous faire basculer vers une société plus responsable sur les plans sociaux et environnementaux ? De nouvelles habitudes et de nouveaux comportements responsables vont-ils se mettre en place de manière durable ? Pour répondre à ces enjeux, cet article mobilise des théories plurielles associées aux changements d’habitudes. Des préconisations s’adressant autant aux entreprises, qu’aux décideurs publics ou citoyens sont proposées pour dessiner les contours d’un après-Covid-19 socialement et écologiquement plus acceptable.
Application of Metanephrine and Normetanephrine in Evaluating the
Selectivity of Adrenal Vein Sampling
Authors: Liu Wei , Zhang Jingjing , Yang Yaling , Jin Yinxin , Li Zaizhao , You Liting , Luo Jianguang , Su Xin
Published: March 2022

The aim of the study was to investigate the usefulness of metanephrine (MN) and
normetanephrine (NMN) in bilateral simultaneous adrenal vein sampling (AVS) with
and without ACTH stimulation. The study was conducted in a single referral
center. Prospective recruited patients with PA were treated with AVS. The
effects of cortisol, MN and NMN on selectivity catheterization were assessed and
determined by lateralization. We enrolled 54 patients with PA who were treated
with simultaneous bilateral AVS with ACTH. The Selectivity Index (SI) calculated
by MN was higher than that calculated by other indicators (p<0.001), the
catheterization success rate of MN at baseline was the same as that of cortisol
after ACTH stimulation, and in lateralization diagnosis, MN was not inferior to
cortisol. In conclusion, among the studied indicators, MN is the best index for
determining the catheterization selectivity in AVS, especially in the absence of
ACTH stimulation.
Gesundheitspolitisches Forum im Rahmen des Nephrologischen Jahresgesprächs 2021
Authors: Schrooten Charlotte , Mc Guinness Anne
Published: March 2022

Thema des Gesundheitspolitischen Forums 2021, das der Verband Deutsche Nierenzentren (DN e. V.) im Rahmen des Nephrologischen Jahresgespräches in Köln Ende November veranstaltete, war „Wie soll die ambulante Dialyseversorgung in Deutschland aussehen und wer gestaltet sie?“.