bluuebunny/crossref_metadata_2025 huggingface dataset:
Crecimiento de Pennisetum purpureum cv. Taiwán con diferentes fuentes de fertilización en pastoreo con bovinos
Authors: Guerra-Medina Cándido Enrique , Ley-de Coss Alejandro , Reyes-Gutiérrez José Andrés , Aveldaño-Arrazate Carlos Hugo , Vicente-Pérez Ricardo , Montañez-Valdez Oziel Dante
Published: January 2022

El objetivo fue evaluar el efecto de dos fuentes de fertilización sobre el valor nutricional, características de crecimiento y persistencia del pasto Taiwán en pastoreo intensivo de becerros en engorda. El estudio se realizó en el municipio de Tapachula, Chiapas, México. Dos fuentes de fertilización aplicadas al pasto Taiwán después del pastoreo de becerros fueron evaluadas; tres tratamientos en un diseño bloques al azar; 1) sin fertilización, 2) fertilizante húmico, 3) fertilizante granulado. Dos alturas de corte de uniformidad después del pastoreo; 1) sin corte de uniformidad; 2) altura de corte a 30 cm, 3) altura de corte a 50 cm. A todas las variables se aplicó un análisis de varianza y pruebas de medias, para observar las diferencias entre tratamientos. El contenido de proteína cruda aumentó de 7.99% a 9.31% y 11.87% en los tratamientos: Pasto Taiwán sin fertilización (TS); Taiwán + fertilizante húmico (TH); Taiwán + fertilizante granulado (TG) de manera respectiva; no hubo efecto del tratamiento aplicado en la mayoría de las variables (P>0.05); mientras que el largo de hoja fue menor (P<0.05) en el pasto Taiwán con fertilizante húmico; el corte de uniformidad después del pastoreo a 30 y 50 cm, aumentó el número de hijuelos (P<0.05). La aplicación de fertilizante húmico y granulado al pasto Taiwán, aumentó el contenido de proteína; el corte de uniformidad a 30 y 50 cm estimuló el desarrollo de mayor número de hijuelos, lo que promueve la persistencia de la pradera.
Calibraciones de espectrofotometría de reflectancia en el infrarrojo cercano para carbohidratos en pasto Urochloa
Authors: Hernández Erika Andrea , Juárez -Lagunes Francisco Indalecio , Montero-Lagunes Maribel , Enríquez-Quiróz Javier Francisco , Loeza-Limón Rubén , Pinos-Rodríguez Juan Manuel
Published: January 2022

El objetivo fue desarrollar modelos de calibración de espectroscopia de reflectancia en el infrarrojo cercano (NIRS) para estimar el contenido de las fracciones de fibra y de carbohidratos en pastos Urochloa sp. para la zona tropical de México. Ciento ochenta y nueve muestras de tres híbridos de Urochloa fueron cosechadas cada 35 días durante un año, las cuales fueron analizadas por química húmeda para las fracciones de fibra: Fibra Detergente Neutra (NDF), Proteína insoluble en Detergente Neutro (NDIP), Fibra Detergente Ácida (ADF), Proteína Insoluble en Detergente Ácido (ADIP) y Lignina (LIG), y se estimaron los carbohidratos totales (TC), carbohidratos fibrosos (FC), carbohidratos no fibrosos (NFC) y carbohidratos indigestibles (UC). Los modelos de calibración y de validación se evaluaron por los respectivos Coeficientes de Determinación (R2); Errores Estándar de Validación Cruzada (SECV); y la desviación residual de la predicción (RPD). Además, con un conjunto de muestras externas, se realizó una prueba de sensibilidad evaluada por el Cuadrado Medio del Error de Predicción (MSPE). Las calibraciones obtenidas presentaron un adecuado ajuste y eficiencia predictiva mediante espectrofotometría NIR para NDF (RPD 2.4) y TC (RPD 2.5) lo que demuestra confiabilidad y capacidad de predicción para estas fracciones. Sin embargo, LIG, FC, NFC y UC requieren más observaciones para acrecentar su confiabilidad.
Macroestructura del huevo de gallinas alimentadas con diferentes niveles de proteína cruda
Authors: Rodríguez-Ortega Leodan Tadeo
Published: January 2022

El nivel de proteína cruda (PC) del alimento se relaciona con su costo y puede afectar características físicas del huevo. El objetivo del estudio fue evaluar el efecto de niveles decrecientes de PC (18, 16 y 12 %) en variables asociadas a la macroestructura del huevo. Cada dieta fue asignada aleatoriamente a 10 repeticiones de cinco aves cada una. Se utilizaron gallinas Bovans White de 131 semanas de edad en segundo ciclo de producción. Durante el periodo experimental se realizaron 15 muestreos (uno cada tercer día), seleccionando al azar tres huevos por repetición para evaluar en cada uno, las variables: peso (P, g), largo (L, mm), ancho (A, mm), índice de forma (IF), volumen (VOL, cm3), área (AR, cm2), masa de albumen (MALB, g), masa de yema (MYEM, g), masa de cáscara (MCAS, g), porcentaje de albumen (%ALB, %), porcentaje de yema (%YEM, %) y porcentaje de cáscara (%CAS, %). Se evaluaron 1,800 huevos en total, 600 por dieta. Los datos se analizaron mediante la metodología de los modelos lineales. El menor nivel de PC en la dieta (12 %) redujo (P<0.05) P, L, A, VOL, AR, MALB y %ALB, pero aumentó IF. No se detectaron diferencias para estas variables entre las dietas con 16 y 18 % PC. Los valores de MCAS y %CAS no fueron diferentes entre tratamientos. Se concluye que 12 % PC en la dieta reduce la magnitud de algunas variables asociadas a la macroestructura del huevo sin afectar la masa y proporción de cascarón.
Estado nutrimental en el extracto celular de pecíolo y hojas de genotipos de jamaica
Authors: Flores-Bernal Emilia F. , Sandoval-Villa Manuel , Guzmán-Martínez María , Espinosa-Rodríguez Mariana , Vázquez-Villamar Mirna , Sabino-López Juan E.
Published: January 2022

Existen varias técnicas de diagnóstico nutrimental en las plantas, que permiten tomar decisiones correctivas de fertilización. Pero, al igual que en otros cultivos, en el de jamaica (Hibiscus sabdariffa L.) no se revisa el estado nutrimental. El objetivo fue estudiar el estado nutrimental de ocho genotipos de H.  sabdariffa L. en floración, mediante el análisis en el extracto celular de pecíolo (ECP), lecturas SPAD y tejido vegetal en laboratorio, para el establecimiento de índices de referencia nutrimental. Se recolectaron y sembraron ocho genotipos de jamaica en bolsas de polietileno de 12 L llenadas con una mezcla de tezontle y tierra de monte (1:1 v/v) en un diseño completamente al azar con cinco repeticiones.  Las plantas crecieron en un invernadero cubierto con plástico blanco de 800 µm con 70% de trasmisión de luz. Las plantas se fertilizaron con 44N-30-20K kg ha-1 y se regaron con agua corriente. Se determinaron las lecturas SPAD en hojas recientemente maduras y en el extracto celular de los peciolos se determinó el NO3-, K+, Ca2+ y Na+ con medidores de bolsillo. Las hojas se procesaron para análisis químico de nitrógeno total, fósforo, potasio, calcio, magnesio, hierro, cobre, zinc, manganeso y boro. Se tuvieron diferencias significativas en los iones para ECP, lecturas SPAD y concentración nutrimental en hojas de los genotipos estudiados.  La concentración de nutrimentos de los iones específicos en el extracto celular de peciolos, lecturas SPAD y en tejido vegetal pueden ser usados como valores de referencia para comparar con estudios posteriores en este cultivo.
Aptitud reproductiva de toros criollo lechero tropical
Authors: Estrella-García Andrea Guadalupe , López-Ortíz Silvia , Canseco-Sedano Rodolfo , Pérez-Hernández Ponciano , Ahuja-Aguirre Concepción del Carmen , Guerrero-Hernández Jonathan
Published: January 2022

El ganado Criollo Lechero Tropical (CLT) posee características deseables para la ganadería tropical. Sin embargo, se desconoce el comportamieto reproductivo de toros CLT de diferentes edades durante las diferentes estaciones del año en clima cálido. En este estudio, ocho toros se asignaron según su edad a los siguientes grupos: 1) G1 (n=5): machos de 19.3 ± 0.4 meses y 260 ± 9 kg de peso y 2) G2 (n=3): toros de 30.5 ± 3.1 meses y 371 ± 29 kg de peso. Durante un año se evaluó la libido en una escala de 0 a 10 puntos y se midieron las concentraciones séricas de testosterona. En las diferentes estaciones del año la libido presentó un puntaje de 8 a 10 para ambos grupos. Los toros del G2 tuvieron mayor concentración de testosterona (P<0.05) y en ambos grupos ésta fue mayor en la mañana (P<0.05). En conclusión, los toros CLT de ambos grupos mostraron un amplio potencial reproductivo durante las diferentes estaciones del año.
Rendimiento, calidad y biogás in vitro en pasto Megathyrsus maximus cv. Aruana con diferente fertilización
Authors: Sánchez-Santillán Paulino , Wilson-García Claudia Yanet , López-Zerón Nelson Erick , Saavedra-Jiménez Luis Antonio , Maldonado-Peralta María de los Ángeles , Melo-Trani Mara Yuciry
Published: January 2022

El objetivo fue evaluar el rendimiento, la composición bromatológica y producción de biogás in vitro con fertilización orgánica e inorgánica, para determinar la edad de corte óptimo del pasto Megathyrsus maximus (Jacq.) B.K. Simon & S.W.L. Jacobs cv. aruana. Los tratamientos fueron: fertilización con composta, lombricomposta, composta más lixiviado y fertilización química. El diseño experimental fue bloques completos al azar, en arreglo de medidas repetidas en el tiempo con tres repeticiones, se realizaron muestreos a los 20, 35, 50, 65, 80 y 95 días después del corte (DDC) de uniformización. Las variables evaluadas fueron acumulación de materia seca, composición morfológica, altura, fibra detergente neutro, fibra detergente acido, materia orgánica, proteína cruda, cenizas y producción de biogás in vitro. Los mayores rendimientos fueron a los 80 DDC con los tratamientos químico y composta más lixiviado con 24 013 y 10 974 kg MS ha?1, respectivamente. En los tratamientos orgánicos se encontró mayor relación hoja: tallo comparado con el químico en todas las fechas evaluadas. Los tratamientos mostraron descenso del porcentaje de proteína cruda conforme avanzó la edad de rebrote. A los 50 y 95 DDC, el pasto aruana fertilizado con lombricomposta o composta más lixiviado produjeron 2.8 y 2.0 veces mayor biogás que el fertilizado con químico o composta. La fecha óptima de corte para el pasto aruana para el tratamiento químico y composta más lixiviado es a los 50 y 65 DDC, mientras que para lombricomposta y composta es a los 65 DDC.
Estabilidad en la población de tallos en cultivares de Urochloa con diferente intensidad de corte
Authors: Lucio-Ruiz Fernando , Garay-Martínez Jonathan R. , Bautista-Martínez Yuridia , Estrada-Drouaillet Benigno , Hernández-Guzmán Filogonio J. , Limas-Martínez Andrés G. , Joaquín-Cancino Santiago
Published: January 2022

Con el objetivo de determinar el efecto de la intensidad de corte sobre la estabilidad poblacional de tallos en cultivares del género Urochloa (híbridos Mulato II, Cayman y Xaraés), empleando un diseño completamente al azar con arreglo factorial (3 × 2 × 11); donde el primer factor fue los cultivares de Urochloa (Mulato II, Cayman y Xaraés), el segundo los niveles de intensidad (fija y 50 %) y 8 fechas de muestreo (cada cuatro semanas). La unidad experimental fue un área de 100 cm2 donde, cada generación (fecha de muestreo) se marcó con aros de diferente color para distinguirlas. Se utilizó un diseño completamente al azar con seis repeticiones por intensidad en cada cultivar. La mayor densidad poblacional de tallos se presentó en la intensidad fija con 2333.66, 2500.77 y 2119.59 tallos m-2, resultado del balance entre la tasa de aparición y muerte, obteniendo tasas de sobrevivencia entre 89.18 y 92.45 % e índices de estabilidad mayores a 0.95 y menores a 1.05, es decir, la intensidad de corte fija de 15 cm para Mulato II y Cayman y 20 cm para Xaraés propicia la estabilidad de la pradera incrementando la persistencia a través del tiempo.
Composición nutricional de tres pastos colectados en el estado de Morelos, México
Authors: Sosa-Montes Eliseo , Mendoza-Pedroza Sergio Iban , Ramos-Velázquez Andrés , Alvarez- Vázquez Perpetuo , Ortega- Jiménez Eusebio , Sánchez- Hernández Miguel Angel
Published: January 2022

El objetivo de este estudio fue evaluar tres pastos forrajeros, Bromus diandrus, Oplismenus burmannii y Heteropogon contortus, de las subfamilias Pooideae, Pooideae y Panicoideae, respectivamente. Las principales variables respuesta, todas en base seca fueron: cenizas (Cen), proteína cruda (PC), extracto etéreo (EE), carbohidratos solubles (CS), fibra detergente neutro (FDN), contenido celular (CC = 100 - FDN) y digestibilidad in vitro de la materia seca (DIVMS). Cada pasto se evaluó por triplicado y una repetición se consideró la unidad experimental. Las medias fueron separadas mediante la prueba de Tukey (p < 0.05). La asociación entre cada par de variables (p < 0.05) se estimó usando el coeficiente de correlación de Pearson (p < 0.05). Los pastos B. diandrus y O. burmannii resultaron con más PC, CC y DIVMS y con menos pared celular o FDN (componente insoluble) que H. contortus. Esto produjo una correlación positiva entre CC y PC (0.751, p < 0.05). Adicionalmente, O. burmannii produjo el valor más alto de Cen y el más bajo de CS, mientras que B. diandrus mostró el valor más bajo de Cen y el más alto de CS. Esto produjo una correlación negativa entre estas dos variables (-0.976, p < 0.01). En conclusión, B. diandrus, mostró mejor composición química y digestibilidad, que los otros dos, por lo que se recomienda este pasto para la nutrición de rumiantes.
CARACTERIZACIÓN Y PROPUESTA DE TRATAMIENTO DE LAS AGUAS RESIDUALES GENERADAS EN LA DIVISIÓN ACADÉMICA DE CIENCIAS BIOLÓGICAS-UJAT
Authors: Reyes Osorio José , Laines Canepa José Ramón , Díaz Paz Roberto Carlos
Published: January 2022

En este estudio se evaluó la situación actual de las principales descargas de aguas residuales en la División Académica de Ciencias Biológicas de la UJAT. Se caracterizaron 3 puntos importantes: la descarga de agua residual por medio de un canal abierto, el agua tratada de la Planta de Tratamiento de Aguas Residuales y el agua de la laguna artificial que recibe las descargas de aguas del área de Acuacultura. Para la propuesta del dimensionamiento del sistema de tratamiento se tomaron como datos importantes dos parámetros que se obtuvieron en la caracterización de la descarga, los cuales son DBO y SST, permitiendo presentar un tratamiento natural a base de lagunas: anaerobias, facultativas y de maduración.
On the Cauchy problem for implicit differential equations of higher orders
Authors: Arutyunov Aram V. , Pluzhnikova Elena A.
Published: January 2022

The article is devoted to the study of implicit differential equations based on statements about covering mappings of products of metric spaces. First, we consider the system of equations
Φ_i (x_i,x_1,x_2,…,x_n )=y_i, i=(1,n,) ̅
where 〖 Φ〗_i: X_i×X_1×… ×X_n→Y_i, y_i∈Y_i, X_i and Y_i are metric spaces, i=(1,n) ̅. It is assumed that the mapping 〖 Φ〗_i is covering in the first argument and Lipschitz in each of the other arguments starting from the second one. Conditions for the solvability of this system and estimates for the distance from an arbitrary given element x_0∈X to the set of solutions are obtained. Next, we obtain an assertion about the action of the Nemytskii operator in spaces of summable functions and establish the relationship between the covering properties of the Nemytskii operator and the covering of the function that generates it. The listed results are applied to the study of a system of implicit differential equations, for which a statement about the local solvability of the Cauchy problem with constraints on the derivative of a solution is proved. Such problems arise, in particular, in models of controlled systems. In the final part of the article, a differential equation of the n-th order not resolved with respect to the highest derivative is studied by similar methods. Conditions for the existence of a solution to the Cauchy problem are obtained.
On an ill-posed boundary value problem for a metaharmonic equation in a circular cylinder
Authors: Laneev Evgeniy B. , Anisimov Viktor A. , Lesik Polina A. , Remezova Viktoriya I. , Romanov Andrey A. , Khegai Anna G.
Published: January 2022

In this paper, we consider a mixed problem for a metaharmonic equation in a domain in a circular cylinder. The cylindrical area is bounded on one side by an arbitrary surface on which the Cauchy conditions are set, i. e. the function and its normal derivative are set. The other border of the cylindrical area is free. On the lateral surface of the cylindrical domain, homogeneous boundary conditions of the first kind are given. The problem is illposed and its approximate solution, stable to errors in the Cauchy data, is constructed using regularization methods. The problem is reduced to a first kind Fredholm integral equation. Based on the solution of the integral equation obtained in the form of a Fourier series by the eigenfunctions of the first boundary value problem for the Laplace equation in a circle, an explicit representation of the exact solution of the problem is constructed. A stable solution of the integral equation is obtained by the method of Tikhonov regularization. The extremal of the Tikhonov functional is considered as an approximate solution. Based on this solution, an approximate solution of the problem as a whole is constructed. A theorem on convergence of the approximate solution of the problem to the exact one as the error in the Cauchy data tends to zero and the regularization parameter is matched with the error in the data, is given. The results can be used for mathematical processing of thermal imaging data in early diagnostics in medicine.
Avaliação de políticas públicas de ciência, tecnologia e inovação
Authors: Sobral Fernanda Antonia da Fonseca , Santos Gilberto Lacerda
Published: January 2022

O conhecimento proveniente da Sociologia da Ciência e da Tecnologia dispõe de status epistemológico para debruçar-se sobre a temática da avaliação de políticas públicas de Ciência, Tecnologia e Inovação (CTI). Nesta perspectiva, este artigo relata o estudo de três casos de avaliação de políticas públicas de CTI, realizados por demanda governamental, os quais nos permitiram rever métodos e propor recomendações.
Response and Side Effects from Rheumatoid Arthritis Therapy at Dr. Soetomo General Hospital Surabaya 2017
Authors: Nisa Ayu Imamatun , Awalia Awalia , Nugraha Jusak
Published: January 2022

Introduction: Rheumatoid arthritis (RA) is an autoimmune disease which mainly attacks synovial membrane and causes systemic manifestation. During treatment, controlling disease activity is needed to prevent further complication. On the other hand, medications used in the treatment of RA may bring various side effects. It is important to evaluate side effects from the given therapy.Methods: This study aimed to evaluate response and side effects of therapy in RA patients. The samples were collected from 59 RA patients at Rheumatology Division of Outpatient Clinic in Department of Internal Medicine Dr. Soetomo General Hospital Surabaya in 2017. This study method was descriptive observational with cross sectional design using medical records.Results: Pain was reduced in 83.1% patients, Erythrocyte Sedimentation Rate (ESR) increased in 61.4% patients, and C-Reactive Protein (CRP) decreased in 50% patients. Based on the statistic analysis, ESR decreased significantly (p = 0.012) while CRP decreased not significantly (p = 0.415). The side effects were observed from clinical and laboratory data. Based on clinical symptoms, there were alopecia in 1.7% patient, dyspepsia in 78% patients, infection in 27.1% patients, and other symptoms including itchy skin, neuropathy, hyperuricemia, hyperkalemia and Acute Kidney Injury (AKI). Meanwhile, abnormalities in laboratory data include increased aspartate transaminase (AST) in 3.8% patients, increased alanine transaminase (ALT) in 26.1% patients, increased Blood Urea Nitrogen (BUN) in 7.9% patients, increased creatinine serum in 7.9% patients, decreased hemoglobin in 15.5% patients, and decreased leukocytes in 3.4% patients.Conclusion: Most patients had a good therapeutic response based on decreased pain, while ESR had a significant decrease and CRP did not have significant decrease. Side effects discovered in patients were various
COMORBIDITIES OF MYASTHENIC CRISIS PATIENTS ACCORDING TO AGE AND GENDER IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA IN 2017-2019
Authors: Rahul Alfaidin Andi Muh , Kalanjati Viskasari P , Basuki Mudjiani
Published: January 2022

Highlight:1. Patients with myasthenia gravis (MG) can have both autoimmune and non-autoimmune comorbidities.2. MG patients were predominantly aged >50 years, females and the commonest comorbidity are hypertension and diabetes mellitus.3. Age and comorbidities were found to have significant correlation among these patients, but not between gender and comorbidities.Abstract:Background:  There are limited studies on the comorbidities of myasthenic crisis (MC) associated with age and gender, specifically from Indonesia. These data might be valuable for treatment to improve the outcome of these patients. Objective: To analyze the correlation between age and gender with the comorbidities amongst the MC patients admitted in the ICU of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2017-2019. Materials and methods:  A retrospective cross-sectional analytic study was conducted on 25 medical records of MC patients who fulfilled the inclusion and exclusion study criteria. Descriptive statistics and Chi-square tests were done to determine the potential correlation between variables (significant level of p<0.05). Results: The age of MC patients was £50 years (80%) and >50 years (20%) while the gender predominantly found were females (68%) with 32% males. A significant correlation was found between age and comorbidities (p=0.002) whilst not between gender and comorbidities (p=0.115). The most common comorbidities observed were hypertension (30%) and diabetes mellitus (20%). Conclusion: There were 40% of patients found with comorbidities. There was a significant association between age and comorbidities found amongst myasthenic crisis patients, whilst no significant association was found between gender and comorbidities.
The Creation Process of The First Particle from the Absolute Void
Authors: Jumaa Shivan
Published: January 2022

In this study, we discuss the properties of absolute vacuum space and how these properties can play a vital role in creating a mechanism in which the very first particle gets created simultaneously everywhere and we find the limit in which when the absolute vacuum volume reaches will lead to the collapse that leads to the creation of the first particle. This discussion is made following to the elementary dimensions theory study that was peer-reviewed at the end of 2020, everything in the universe is made from four elementary dimensions, these dimensions are the three spatial dimensions (X, Y, and Z) and the Vacuum resistant as the factor of change among the four, time itself wasn’t considered as the fourth dimension, rather time corresponds to a factor of change, and during the research it was found out that the Vacuum resistant is the factor of change in the Absolute Vacuum space, where time is a hypothetical concept, that represents changes during certain events compared to a constant change rate event.Therefore, time does exist, but as a factor of change, and as the Vacuum resistant in the absolute vacuum space, Time= factor of change= Vacuum resistant. In the study, the internal and external vacuum resistant volume equivalent is found, External Vacuum resistant=3.2857602*10^15 *mass. This equation is used to identify the amount of Free external vacuum resistant created during nuclear fission and fusion: Initial mass of the excited nucleuses mass of the created new nucleuses+ 3.2857602*10^15 * the lost Mass. In elementary dimensions, the energy created during nuclear reactions is equivalent to the free External vacuum resistant created through nuclear reactions, and mass is equivalent to the internal Vacuum resistant.
On Generalized Padovan Numbers
Authors: Soykan Yüksel
Published: January 2022

In this paper, we investigate the generalized Padovan sequences and we deal with, in detail, four special cases, namely, Padovan, Perrin, Padovan-Perrin and modified Padovan sequences. We present Binet's formulas, generating functions, Simson formulas, and the summation formulas for these sequences. Moreover, we give some identities and matrices related with these sequences.
Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction
Authors: Park Eun S. , Kim Sehee , Yao Derek. C. , Savarraj Jude P.J. , Choi H. Alex , Chen Peng R. , Kim and Eunhee
Published: January 2022

Increased soluble endoglin (sENG) were observed in human brain arteriovenous malformations (bAVMs), and overexpression of sENG with vascular endothelial growth factor (VEGF)-A induced dysplastic vessel formation in mouse brain. However, the underlying mechanism of sENG-induced vascular malformations is not clear. While evidence suggests the role of sENG as a pro-inflammatory modulator, increased microglial accumulation and inflammations were observed in bAVMs. Therefore, we hypothesized that microglia mediate sENG-induced inflammation and endothelial cell (EC) dysfunction in bAVMs. In this study, we confirmed that sENG with VEGF-A overexpression induced dysplastic vessel formation. Remarkably, there were increased microglial activation around dysplastic vessels with expression of NLRP3, inflammasome marker. We found that sENG increased the gene expression of VEGF-A, pro-inflammatory cytokines/inflammasome mediators (TNF-α, IL-6, NLRP3, ASC, Caspase-1, and IL-1β), and proteolytic enzyme (MMP-9) in BV2 microglia. The conditioned media from sENG-treated BV2 (BV2-sENG-CM) significantly increased angiogenic factors (Notch-1 and TGFβ) and pERK1/2 in ECs while it decreased IL-17RD, an anti-angiogenic mediator. Finally, the BV2-sENG-CM significantly increased EC migration and tube formation. Together, our study demonstrates that sENG provokes microglia to release angiogenic/inflammatory responses which may be involved in EC dysfunction. Our study suggests the contribution of microglia in the pathology of sENG-associated vascular malformations.
HU - The Big Pop Cosmogenesis Equation of State
Authors: Pereira Marco
Published: January 2022

HU is the Hypergeometrical Universe Theory (HU)[1-8], proposed in 2006, where the Universe is a Lightspeed Expanding Hyperspherical Hypersurface and Gravitation is an absolute-velocity-dependent, epoch-dependent force. Here we introduce the Big Pop Cosmogenesis and show our calculations associated with the Equation of State of the Universe. This article is the first in a series of articles[9-22] supporting the paradigm shift.
Spermidine Binding to the Acetinobacter baumannii Efflux Protein AceI Observed by Near-UV Synchrotron Radiation Circular Dichroism Spectroscopy
Authors: Patching Simon
Published: January 2022

The aim of this work was to test polyamines as potential natural substrates of the Acinetobacter baumannii chlorhexidine efflux protein AceI using near-UV synchrotron radiation circular dichroism (SRCD) spectroscopy. The Gram-negative bacterium A. Baumannii is a leading cause of hospital-acquired infections and an important foodborne pathogen. A. Baumannii strains are becoming increasingly resistant to antimicrobial agents, including the synthetic antiseptic chlorhexidine. AceI was the founding member of the recently recognised PACE family of bacterial multidrug efflux proteins. Using the plasmid construct pTTQ18-aceI(His6) containing the A. Baumannii aceI gene directly upstream from a His6-tag coding sequence, expression of AceI(His6) was amplified in E. coli BL21(DE3) cells. Near-UV (250-340 nm) SRCD measurements were performed on detergent-solubilised and purified AceI(His6) at 20 °C. Sample and SRCD experimental conditions were identified that detected binding of the triamine spermidine to AceI(His6). In a titration with spermidine (0-10 mM) this binding was saturable and fitting of the curve for the change in signal intensity produced an apparent binding affinity (KD) of 3.97 +/- 0.45 mM. These SRCD results were the first experimental evidence obtained for polyamines as natural substrates of PACE proteins.
Late Time Acceleration of the Universe from Quantum Gravity
Authors: Pang Xiankai
Published: January 2022

We show that the accelerating expansion phase of the universe can emerge from the group field theory formalism, a candidate theory of quantum gravity. The cosmological evolution can be extracted from condensate states using mean field approximation, in a form of modified FLRW equations. By introducing an effective equation of state w, we can reveal the relevant features of the evolution, and show that with proper choice of parameters, w will approach to −1, corresponds to the behaviour of cosmological constant, results in a late time acceleration and leads to de Sitter spacetime asymptotically.
Urban Flood Risk Assessment: Integration of Decision Making and Machine Learning
Authors: Taromideh Fereshteh , Fazloula Ramin , Choubin Bahram , Emadi Alireza , Berndtsson Ronny
Published: January 2022

Urban flood risk mapping is an important tool for the mitigation of flooding in view of human activities and climate change. Many developing countries, however, lack sufficiently detailed data to produce reliable risk maps with existing methods. Thus, improved methods are needed that can improve urban flood risk management in regions with scarce hydrological data. Given this, we estimated the flood risk map for Rasht City (Iran), applying a composition of decision-making and machine learning methods. Flood hazard maps were produced applying six state-of-the-art machine learning algorithms such as: classification and regression trees (CART), random forest (RF), boosted regression trees (BRT), multivariate adaptive regression splines (MARS), multivariate discriminant analysis (MDA), and support vector machine (SVM). Flood conditioning parameters applied in modeling were elevation, slope angle, aspect, rainfall, distance to river (DTR), distance to streets (DTS), soil hydrological group (SHG), curve number (CN), distance to urban drainage (DTUD), urban drainage density (UDD), and land use. In total, 93 flood location points were collected from the regional water company of Gilan province combined with field surveys. We used the Analytic Hierarchy Process (AHP) decision-making tool for creating an urban flood vulnerability map, which is according to population density (PD), dwelling quality (DQ), household income (HI), distance to cultural heritage (DTCH), distance to medical centers and hospitals (DTMCH), and land use. Then, the urban flood risk map was derived according to flood vulnerability and flood hazard maps. Evaluation of models was performed using receiver-operator characteristic curve (ROC), accuracy, probability of detection (POD), false alarm ratio (FAR), and precision. The results indicated that the CART model is most accurate model (AUC = 0.947, accuracy = 0.892, POD = 0.867, FAR = 0.071, and precision = 0.929). The results also demonstrated that DTR, UDD, and DTUD played important roles in flood hazard modeling; whereas, the population density was the most significant parameter in vulnerability mapping. These findings indicated that machine learning methods can improve urban flood risk management significantly in regions with limited hydrological data.
ESTILOS DE APRENDIZAJE ÉTICO - SOSTENIBLE DEL CONTADOR PÚBLICO
Authors:   Corporación Universitaria Remington, GUZMAN FEIBERT , MAYA LINA , PEREZ LUIS , FLOREZ MARIO
Published: January 2022

This paper, show the impact that the use of the Ethical-Sustainable reference framework (emphasis on Corporate Social Responsibility- ISO 26000) and behavior with social and ethical responsibility of the population has on the teaching-learning process, object of study. Methodologically and with the support of the multivariable statistical method, teacher-student learning styles are validated in terms of emotional intelligence, developing critical thinking that potentializes autonomous and collaborative learning, with the aim of transcending knowledge under the framework of integration of sustainability and ethics in professional practice. Finally, the measurement indicators are obtained through empirical evidence with several structured questionnaires that measure the factors of the learning styles, based on the emotional intelligence, which are reflected in the self-knowledge and behavior of the students, under a framework of ethical- sustainable reference.
THE FIGHT AGAINST CORRUPTION IN THE PUBLIC ADMINISTRATION OF BRAZIL
Authors:   Universidad de Buenos Aires, IUNG FRANCIELI , SAMPAIO DE OLIVEIRA JAQUELINE
Published: January 2022

The present bibliographical research aims to present the types of corruption practiced against the Public Administration. From this study, it is verified that the fight against corruption depends on the maturing of a democratic conscience that makes possible the popular participation in the monitoring of the activities developed by the Public Adminis- tration in all spheres of the Power of the Federative Republic of Brazil aiming at the continuous supervision of the institutions public policies. Currently, there are several actions, institutions, and groups involved, including at the international level, to combat corruption. The corrupt activities are multi- plied, due to the difficulty of investigation and proper punishment of the criminal acts, besides the little popular participation in the process of control of the public administrations. Finally, it is considered important that all control institutions participate in an integrated manner with the participation of the population in the fight against corruption.
IMPORTANCIA DE LOS SISTEMAS DE CONTROL INTERNO PARA PYMES ENCAMINADO A LA MITIGACIÓN DE RIESGOS OPERATIVOS
Authors:   Corporación Universitaria Republicana, PEDRAZA JESSICA , ORTIZ DIANA , LEÓN BRYAN , NARANJO JHON
Published: January 2022

In a globalized world as the economy of these times unfolds, as the territorial barriers and spatial limits have been broken and commercial places are now global. The companies, especially small and medium-sized ones, must face different challenges that expose them to a universe of potential risks in which they can be affected economically, legally and repu- tational; a large number of companies aren’t prepared to assume these risks and do not have the necessary tools to defend themselves in these situations, especially because these companies and their managers work empi- rically. This is why the question arises about whether it is possible to define models of internal control that are adapted to the specific conditions of companies, which allow them to develop efficiently in a world of glo- bal competition.
AUDITORÍA TRIBUTARIA DE IMPUESTOS NACIONALES: ANÁLISIS A PARTIR DE LAS PRUEBAS SUSTANTIVAS Y PRUEBAS DE CUMPLIMIENTO
Authors:   Universidad Cooperativa de Colombia, HERNANDEZ LUDIVIA , FLOREZ MARIO , ARIAS CAMILA , ANGARITA BRAYAN
Published: January 2022

The purpose of this article is to analyze the substantive and compliance tests in a tax audit of national taxes in Colombia; With the entry of the International Financial Reporting Standards (IFRS), from Law 1314 of 2009, the process of convergence of Accounting Principles Generally Accepted in Colombia (GAAP) to IFRS was originated; At present, the accounting records and processes are made under IFRS, therefore, it begins with the characterization of the risks that make up the audit process according to the Information Assurance Rules; The applicable current regulations will be conceptualized to carry out the elaboration of said tests and, finally, the information will be analyzed in favor of the substantive and compliance tests, which allows observing the processes and procedures that the auditor must perform to collect the evidence. evidence that allows you to elaborate an opinion according to fundamental ethical principles.
SUSTENTACIÓN DE UN OBSERVATORIO ARQUITECTÓNICO EN LA UNIVERSIDAD ANTONIO NARIÑO, SEDE VILLAVICENCIO (META)
Authors:   Corporación Universitaria Republicana, NARANJO SANDRA , GONZALEZ JUAN
Published: January 2022

This article presents the results of the interdisciplinary collaboration of the authors, from their fields of research, to reflect on the guidelines of the three substantive functions of the university: training, research and extension, linked these last two with the social projection, to support the design of an architectural observatory at the Antonio Nari- ño University, Villavicencio headquarters, under the premise that a research scenario of this type, in addition to linking these functions offers a series of conditions and benefits in terms of the demands of university education and the role of the university in society.
How distinctive are flood-triggered turbidity currents?
Authors: Heerema Catharina J. , Cartigny Matthieu J.B. , Jacinto Ricardo Silva , Simmons Stephen M. , Apprioual Ronan , Talling Peter J.
Published: January 2022

Turbidity currents triggered at river mouths form an important highway for sediment, organic carbon, and nutrients to the deep sea. Consequently, it has been proposed that the deposits of these flood-triggered turbidity currents provide important long-term records of past river floods, continental erosion, and climate. Various depositional models have been suggested to identify river-flood-triggered turbidite deposits, which are largely based on the assumption that a characteristic velocity structure of the flood-triggered turbidity current is preserved as a recognizable vertical grain size trend in their deposits. Four criteria have been proposed for the velocity structure of flood-triggered turbidity currents: prolonged flow duration; a gradual increase in velocity; cyclicity of velocity magnitude; and a low peak velocity. However, very few direct observations of flood-triggered turbidity currents exist to test these proposed velocity structures. Here we present direct measurements from the Var Canyon, offshore Nice in the Mediterranean Sea. An acoustic Doppler current profiler was located 6 km offshore from the river mouth, and provided detailed velocity measurements that can be directly linked to the state of the river. Another mooring, positioned 16 km offshore, showed how this velocity structure evolved down-canyon. Three turbidity currents were measured at these moorings, two of which are associated with river floods. The third event was not linked to a river flood and was most likely triggered by a seabed slope failure. The multi-pulsed and prolonged velocity structure of all three (flood- and landslide-triggered) events is similar at the first mooring, suggesting that it may not be diagnostic of flood triggering. Indeed, the event that was most likely triggered by a slope failure matched the four flood-triggered criteria best, as it had prolonged duration, cyclicity, low velocity, and a gradual onset. Hence, previously assumed velocity-structure criteria used to identify flood-triggered turbidity currents may be produced by other triggers. Next, this study shows how the proximal multi-pulsed velocity structure reorganizes down-canyon to produce a single velocity pulse. Such rapid-onset, single-pulse velocity structure has previously been linked to landslide-triggered events. Flows recorded in this study show amalgamation of multiple velocity pulses leading to shredding of the flood signal, so that the original initiation mechanism is no longer discernible at just 16 km from the river mouth. Recognizing flood-triggered turbidity currents and their deposits may thus be challenging, as similar velocity structures can be formed by different triggers, and this proximal velocity structure can rapidly be lost due to self-organization of the turbidity current.
Perfil e desempenho de uma turma de graduação da medicina veterinária frente a metodologias ativas de ensino e avaliação da aprendizagem
Authors: Bianchi Ivan , Rosa Emanoelle Regina , Ribeiro Carvalho de Brito Camila , Somensi Cleder Alexandre
Published: January 2022

O objetivo deste projeto foi utilizar metodologias pedagógicas para incorporar a pesquisa e o empreendedorismo ao ensino e aprendizagem. O estudo foi conduzido com os alunos da disciplina de “Fisiopatologia da Reprodução” do curso de Medicina Veterinária do IFC Campus Araquari. Durante o semestre foram utilizadas as seguintes metodologias de ensino: aula expositiva e prática, relatório de aula prática, seminários e elaboração de um Plano de Negócios. Ao final do semestre foram avaliadas as notas obtidas pelos estudantes e aplicado um questionário. Foi observado um elevado percentual de estudantes desperiodizados (28,5%). De acordo com os estudantes, a disciplina atingiu o objetivo e contribuiu positivamente ao ensino e aprendizagem. Além disso, a maioria sugere a continuidade das metodologias utilizadas nos próximos semestres, embora tenha sido demonstrado que nem todos participam quando o trabalho é em grupo. Aula prática é a metodologia de ensino preferida pelos estudantes, mas para obtenção da nota é, na sequência, prova escrita e seminário. As mulheres alcançam notas médias superiores aos homens, independente da metodologia aplicada. O uso de PDF das aulas é a forma mais usual de estudo. Para assuntos técnicos os estudantes costumam buscar artigos no Portal Periódico CAPES, enquanto o uso de sites é o veículo preferido para se informar de assuntos gerais. O uso de metodologia ativas durante a disciplina oportunizou trabalhar habilidades e competências nos estudantes relacionadas a autonomia intelectual, capacidade de interpretar, analisar, criticar, refletir, rejeitar ideias, aprender, buscar soluções e propor alternativas.
A Novel Approach to Reservoir Simulation of Hydraulic Fractures: Performance Improvement Using Pseudo Well Connections
Authors: Lokhandwala Aamir , Joshi Vaibhav , Dutt Ankit
Published: January 2022

Reservoir simulation is used in most modern reservoir studies to predict future production of oil and gas, and to plan the development of the reservoir. The number of hydraulically fractured wells has risen drastically in recent years due to the increase in production in unconventional reservoirs. Gone are the days of using simple analytic techniques to forecast the production of a hydraulic fracture in a vertical well, and the need to be able to model multiple hydraulic fractures in many stages over long horizontals is now a common practice. The type of simulation approach chosen depends on many factors and is study specific. Pseudo well connection approach was preferred in the current case.

Due to the nature of the reservoir simulation problem, a decision needs to be made to determine which hydraulic fracture modeling method might be most suitable for any given study. To do this, a selection of methods is chosen based on what is available at hand, and what is commonly used in various reservoir simulation software packages. The pseudo well connection method, which models hydraulic fractures as uniform conductivity rectangular fractures was utilized for a field of interest referred to as Field A in this paper. Such an assumption of the nature of the hydraulic fracture is common in most modern tools.

Field A is a low permeability (0.01md-0.1md), tight (8% to 12% porosity) gas-condensate (API ~51deg and CGR~65 stb/mmscf) reservoir at ~3000m depth. Being structurally complex, it has a large number of erosional features and pinch-outs. The pseudo well connection approach was found to be efficient both terms of replicating data of Field A for a 10 year period while drastically reducing simulation runtime for the subsequent 10 year-period too. It helped the subsurface team to test multiple scenarios in a limited time-frame leading to improved project management.
Multiple In-Situ Stress Measurements in Carbonate Reservoirs for CO2 Injection Capability Assessment and Far-Field Strain Calibrations
Authors: Franquet Javier Alejandro , Telang Viraj Nitin , Jibar Hayat Abdi Ibrahim , Khan Karem Alejandra
Published: January 2022

The scope of this work is to measure downhole fracture-initiation pressures in multiple carbonate reservoirs located onshore about 50 km from Abu Dhabi city. The objective of characterizing formation breakdown across several reservoirs is to quantify the maximum gas and CO2 injection capacity on each reservoir layer for pressure maintenance and enhance oil recovery operations. This study also acquires pore pressure and fracture closure pressure measurements for calibrating the geomechanical in-situ stress model and far-field lateral strain boundary conditions.

Several single-probe pressure drawdown and straddle packer microfrac injection tests provide accurate downhole measurements of reservoir pore pressure, fracture initiation, reopening and fracture closure pressures. These tests are achieved using a wireline or pipe-conveyed straddle packer logging tool capable to isolate 3 feet of openhole formation in a vertical pilot hole across five Lower Cretaceous carbonate reservoirs zones. The fracture closure pressures are obtained from three decline methods during the pressure fall-off after fracture propagation injection cycle. The three methods are: (1) square-root of the shut-in time, (2) G-Function pressure derivative, and (3) Log-Log pressure derivative. The far-field strain values are estimated by multi-variable regression from the microfrac test data and the core-calibrated static elastic properties of the formations where the stress tests are done.

The reservoir pressure across these carbonate formations are between 0.48 to 0.5 psi/ft with a value repeatability of 0.05 psi among build-up tests and 0.05 psi/min of pressure stability. The formation breakdown pressures are obtained between 0.97 and 1.12 psi/ft over 5,500 psi above hydrostatic pressure. The in-situ fracture closure measurements provide the magnitude of the minimum horizontal stress 0.74 - 0.83 psi/ft which is used to back-calculate the lateral strain values (0.15 and 0.72 mStrain) as far-field boundary condition for subsequent geomechanical modeling.

These measurements provide critical subsurface information to accurately predict wellbore stability, hydraulic fracture containment and CO2 injection capacity for effective enhance oil recovery within these reservoirs. This in-situ stress wellbore data represents the first of its kind in the field allowing petroleum and reservoir engineers to optimize the subsurface injection plans for efficient field developing.