bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Effect of Near Infra-red Spectroscopy (NIRS) on Early Diagnosis of Cardiac Surgery Associated Acute Kidney Injury
Authors: zadeh Fatemeh Javaherforoosh , Bhandori Hojatolah , Jarirahmadi Sara , Bakhtiari Nima
Published: September 2020

Background. Cardiac surgery-associated acute kidney injury (CSA –AKI), is a major complication of cardiac surgery. Early detection of this complication can improve the quality of post-operative care and help to prevent this phenomenon.Materials and Methods: 148 patients were enrolled to study and 107 patients were selected for analysis between February and September 2019 in the cardiac surgery unit of Golestan Hospital. Ahvaz. Iran. Kidney tissue oxygen saturation was measured in multiple definite times during surgery. Hemoglobin, blood urea nitrogen, creatinine, and lactate were measured during and 48 hours after surgery.Results: Forty-one patients were diagnosed of CSA-AKI according to KDIGO criteria. Parametric and non-parametric analyzes significant difference was not detected between CSA-AKI and NON CSA-AKI group in the demographic parameter. Repeated measurement of ANOVA Analysis did not show any significant difference in parameters except for BUN. Repeated measurement of ANOVA showed a significant difference in both groups and time factors (p<0.001, p=0.0006 respectively). ROC curve analyzes showed in a single point of time, difference the middle of CPB time from baseline high-value in the prediction of AKI 0.764 (0.57 to 0.951) (AUC-CI). Conclusion; Kidney saturation monitoring could be considered as routine monitoring in cardiac surgery for the rapid detection of CSA -AKI. Although kidney tissue saturation is not correlated directly to the arterial saturation of oxygen, physician and surgery team could predict the chance of acute kidney injury exposure.
Longitudinal Use of the Consolidated Framework for Implementation Research to Evaluate the Creation of a Rural Center of Excellence in Transgender Health
Authors: Tinc Pamela Jane , Wolf-Gould Christopher , Wolf-Gould Carolyn , Gadomski Anne
Published: September 2020

BackgroundTransgender people face numerous barriers to accessing care, particularly in rural settings. Transportation, travel time, a lack of providers offering transgender care, and discrimination all contribute to these barriers. The Gender Wellness Center was established to fill a gap in rural transgender care, and was subsequently awarded a Robert Wood Johnson Foundation grant to establish a Center of Excellence. This study examines the implementation of the Center of Excellence, a complex intervention, over the course of 18 months.MethodsThe Consolidated Framework for Implementation Research was used to develop baseline and follow-up surveys. These were distributed to members of the core implementation team at the Gender Wellness Center at the midpoint and conclusion of the Robert Wood Johnson Foundation grant. Responses were largely open-ended and analyzed qualitatively.ResultsResults are presented in terms of Consolidated Framework domains and constructs, as well as the relative outlook (positive or negative) of implementation. Overall, there were improvements over time, with more encouraging feedback and examples of success at follow-up. Though true, organizational culture and individual beliefs about the provision of transgender care challenged implementation of the Center of Excellence throughout the project.ConclusionsThis study highlights the importance of organizational culture on implementation efforts, as well as the need for complex, multi-faceted interventions to overcome such challenges in order to improve care for marginalized populations.Trial registrationNot applicable
A Long-Term Control Study of the Treatment of Cervical Radiculopathy by Percutaneous Endoscopic Posterior Cervical Discectomy and Anterior Cervical Decompression, Bone Graft Fusion and Internal Fixation
Authors: Huang Xiaodong , Wang Weiheng , Meng Qingxi , Yu Jiangming , Ye Xiaojian
Published: September 2020

BackgroundCervical spondylotic radiculopathy (CSR) is very common all over the world. However, there are only a few reports about the efficacy of percutaneous endoscopic posterior cervical discectomy (PEPCD) in the treatment of CSR. Anterior cervical decompression and fusion (ACDF) and PEPCD which is a better way to treat CSR need further study.MethodsFrom January 2015 to December 2016. A retrospective study of 70 patients undergoing surgery for CSR (33 using PEPCD and 37 using ACDF). The intra-operative parameters, neck disability index (NDI), neck and arm visual analog scale (VAS) score were used to assessed clinical outcome. Radiological outcomes were assessed by measuring cervical 2-7 (C2-7) lordosis, disc height index (DHI), and degree of degenerative changes at the corresponding level.ResultsThe mean follow-up period was 48.5 month (36 –66 months). Two groups can significantly improve the clinical symptoms. There was no significant difference between the two groups in clinical results (VAS, NDI). Compared with preoperative, the lordosis of C2-7 increased significantly at the last follow-up. At the last follow-up, C2-7 lordosis in the ACDF group was significantly higher than that in the PEPCD group. In PEPCD, compared with preoperative, there was no significant difference in the DHI, but the degree of disc degeneration was significantly increased at the last follow-up.ConclusionFor patients with CSR, PEPCD had similar clinical early and intermediate outcomes when compared with ACDF, with the advantages of minimally invasive. PEPCD is a sufficient and safe supplement and alternative to conventional surgery.
Numerical Simulation of Transient Cavitation Characteristics of Valve-Controlled Liquid-Filled Hydrodynamic Coupling
Authors: Cui Hongwei , Zhang Jiahua , Wang Guoqiang
Published: September 2020

In high-power impeller industries, valve-controlled liquid-filled hydrodynamic couplings are widely used in the soft startup of heavy-duty scraper conveyors for mining. However, the water circulation speed in internal flow fields is higher at lower speed ratios, making the hydrodynamic couplings prone to severe cavitation, which further results in severe performance degradation, noise, vibration, or even erosion failure. Meanwhile, because a hydrodynamic coupling is a piece of closed-loop multicomponent turbomachinery, internal transient cavitation flow behavior cannot be easily controlled. To reasonably predict the characteristics of cavitation and its influence on the working performance of the hydrodynamic coupling, a high-quality structured mesh model of the internal flow field for an impeller was established. Considering the periodic structural characteristics of the impeller, a scale-resolving simulation turbulence model was combined with a Rayleigh–Plesset cavitation model to establish a single-cycle hydrodynamic coupling calculation model. The cavitation distribution characteristics and torque transmission of the flow field under different working conditions were obtained, and the effect of cavitation on the soft startup performance was analyzed. The results demonstrated that cavitation in the hydrodynamic coupling mainly occurred under low speed ratios. The degree of cavitation decreased as speed ratio increased. The worst-case scenario for cavitation occurred when the speed ratio was zero. Most of the cavitation bubbles were generated at the tip of the blades, resulting in unstable variation in torque characteristics and deterioration of the working performance of the hydrodynamic coupling. The analysis reveals that the cavitation process in the impeller is highly unstable and periodic, and the cavitation development near the tip of the blades occurs in four stages: birth, growth, separation, and disintegration. The generated steam accumulates in the inner ring of the impeller. Therefore, a method for accurately predicting the cavitation characteristics of hydrodynamic couplings based on high-precision technology is proposed, and a theoretical basis for coupling design and cavitation suppression technology is provided.
The Effect of a Decision-Support mHealth Application on Maternal and Neonatal Outcomes in Two District Hospitals in Rwanda: Quasi-Experimental Study
Authors: Nishimwe Aurore , Ibisomi Latifat , Nyssen Marc , Conco Daphney Nozizwe
Published: September 2020

Background: Globally, mobile health (mHealth) applications are known for their potential to improve healthcare providers’ access to relevant and reliable health information. Besides, electronic decision support tools, such as the Safe Delivery mHealth Application (SDA), help to reduce clinical errors and to ensure quality care at the point of service delivery. The current study assessed the effects of the SDA on basic emergency obstetric and newborn care (BEmONC) outcomes for the most frequent complications in Rwanda; post-partum haemorrhage (PPH) and newborn asphyxia and its complications.Methods: The study adopted a quasi-experimental design. A pre-intervention record review of the BEmONC outcomes: Apgar score and PPH progressions, was conducted. The intervention took place in two district hospitals in Rwanda and entails the implementation of the SDA for six months. Six months’ post-intervention, the effect of the SDA on BEmONC outcomes was evaluated. The study included 327 participants (114 cases of PPH and 213 cases of neonatal complications). The analysis compared the outcome variables between the baseline and the endline data. Fisher’s exact test was used to compare the proportions and test between-group differences and significance level set at p<0.05. Results: Unstable newborn outcome following neonatal resuscitation was recorded in 61.90% and 27.59% newborns cases at baseline and endline respectively, P-value = 0.000. Unstable maternal outcome following PPH management was recorded in 19.40 % and 6.38% maternal cases at baseline and endline respectively, P-value = 0.048. There was a significant association between the SDA intervention and newborns’ and maternal’ outcomes following neonatal resuscitation and PPH management, 6 months after baseline.Conclusion: The use of the SDA supported nurses and midwives in the management of PPH and neonatal resuscitation thus improved maternal and neonatal outcomes after 6 months of the SDA intervention.
Clinical Analysis of Gastrointestinal Bleeding in Patients with Severe Coronavirus Disease (COVID-19): A Retrospective Observational Study
Authors: Dai Jinfen , Hu Song , Chen Yi , Wu Pengbo , Liu Mei
Published: September 2020

Background: The epidemic of Novel coronavirus disease 2019(COVID-19) has attracted the great attention of people all over the world. Gastrointestinal bleeding in patients with COVID-19 has been studied rarely. We mean to investigate the clinical characteristics of gastrointestinal bleeding in patients with severe coronavirus disease (COVID-19).Methods: Nineteen severe COVID-19 patients with gastrointestinal bleeding were retrospectively studied. Clinical data, including medical history, symptoms, laboratory characteristics, and treatment, were collected and analyzed. We also compared the characteristics of patients with different degrees of bleeding.Results: Fourteen patients (73.6%) were men. Mean age was 63.8 (±15.6) years. Most patients (89.4%) had no history of gastrointestinal bleeding. The most common presentation of gastrointestinal bleeding was a positive fecal occult blood test (15/19 cases, 78.9%). Fifteen patients (78.9%) did not require blood transfusion. Five of 15 patients (33%) received anticoagulants and antiplatelet drugs before gastrointestinal bleeding in the mild bleeding group, and 2/4 (50%) in the severe bleeding group. Four of 15 patients (27%) died in the mild bleeding group and no patients died in the severe bleeding group.Conclusions: The presentations of gastrointestinal bleeding in severe COVID-19 patients are not obvious, and frequent fecal occult blood test is needed to detect gastrointestinal bleeding early. Patients receiving anticoagulants and antiplatelet drugs need a close observation for gastrointestinal bleeding. Gastrointestinal bleeding may not increase the mortality, after giving blood transfusion support therapy.
Prognostic Role of TLE Family in Lung Adenocarcinoma
Authors: Ma Qianli , Xiao Fei , Xing Huajie , Song Zhiyi , Zhang Jin , Si Chaozeng , Liang Chaoyang
Published: September 2020

Background Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Lung adenocarcinoma (LUAD) is the most common type of lung cancer. Transducin-like Enhancer of split (TLE) family proteins repress transcription by multiple mechanisms. The prognostic role of TLEs in LUAD is still unclear. Methods We took TCGA dataset to analyze the relationship between the expression of TLEs and LUAD outcome. Results The expression of TLEs were different between 59 normal and 513 tumor samples. High TLE1 and low TLE2 were associated with poor PFS and OS (all p＜0.050). Multivariate analysis demonstrated that high TLE1 and low TLE2 were independent risk factors. Moreover, the combination of TLE1 and TLE2 was a better tool in prognostication. Conclusions High TLE1 and low TLE2 expressions are independent adverse prognostic factors and can be used as prognostic biomarkers in LUAD.
miR155 Enhances Autophagy by Reducing MBD5 and METTL3 in Human Liver Cancer Stem Cells
Authors: Lu Yanan , Chen Yingjie , Xin Xiaoru , Song Shuting , Jiang Xiaoxue , Xie Sijie , Wang Liyan , Lu Dongdong
Published: September 2020

Background: miR-155 is a widely reported carcinogenic miRNA, with up-regulated expression in a variety of human cancers. Methods: Liver cancer stem cells were isolated from Huh7 cells; gene infection, RT-PCR, Western blotting and tumorigenesis test in vitro and in vivo were performed to analyze the signaling pathway. Results: we demonstrate that miR-155 inhibits the expression of MBD5 and METTL3 , reducing the expression of DNMT1. In particular, miR155 inhibits the interaction between MBD5 and DNMT1, thereby inhibiting the binding capacity among MBD5, DNMT1 and IGFII (H19 ICR, IGFII DMR, IGFII Enhancer) DNA, inhibiting IGFII DNA methylation modification. Importantly, miR-155 promotes the formation of DNA loops in the IGFII DNA region (H19 ICR-IGFII Enhancer, IGFII DMR-IGFII Enhancer). Therefore, miR155 promotes the binding ability of H19-pre miR675 to histone methyltransferases SUV39h2 dependent on the H19 ICR-IGFII enhancer DNA loop and enhances the methylation modification of histone H3 on the ninth lysine . Then, the binding ability of RNA polII to P300 was enhanced by the formation of H3K9me2-RNA polII-P300 complex. Furthermore, miR155 promotes the binding ability of the RNA PolII-P300 complex to the IGFII promoter dependent on the IGFII DMR-IGFII enhancer DNA loop and promotes the expression of IGFII. Further research shows that miR155 promotes the binding of IGFII to stemness factors and the loading of stemness factors into the promoter region of HGF, which promotes the expression of hepatocyte growth factor HGF. In particular, miR155 promotes the expression of albumin gene (ALB) via HGF-c-MET, and then promotes the Sirt1 expression through ALB. Strikingly, miR155 promotes the autophagy dependent on acetylase Sirt1,including that miR155 promotes LC3 activation dependent on acetylase sirt1 and enhances binding capacity of LC3 to TP53INP2 / DOR, ATG4, ATG3 and ATG7, and the binding ability of the interaction between ATG5, ATG12, ATG6L1, ATG9. More meaningfully, miR155 enhances the ability of H-Ras to bind to the autophagosomes Beclin1, vps34, vps5, Uvrage, bif1, Lamp1, Lamp2, Lamp3, Rubicon, Rab24 dependent on autophagy, thereby enhancing the expression of H-Ras. Furthermore, miR155 enhances the expression of pRaf1, pMEK1 / 2, pERK1 / 2, pElK, pJak, Jun, pAKT, pmTOR, P70S6K, 4E-BP1, SGK1, C-myc dependent on H-Ras.Finally, miR-155 promotes the malignant growth of human liver cancer stem cells mediated by H-Ras.Conclusions: these results provide a valuable theoretical basis for therapeutic targets of liver cancer based on miR-155.
Bibliometric Study of the Most Influential 100 Publications in Vertebral Augmentation Research
Authors: WANG Shuang , JI Nan , WANG Shuai , FU Yu-ping , WANG Hai-zhou , YU Zhuo-li
Published: September 2020

Purpose A bibliometric study was conducted to identify and analyze the most influential 100 publications in vertebral augmentation research.Methods Databases of Web of Science and Pubmed were searched using the key words of ‘percutaneous vertebroplasty’, ‘percutaneous kyphoplasty’, ‘balloon kyphoplasty’, ‘vertebroplasty’, ‘kyphoplasty’ and ‘vertebral augmentation’. The searched publications were arranged by the times of cited per year after excluding the papers not associated with vertebral augmentation closely. The top 100 publications were defined as the most influential papers in this field and analyzed. Collecting data included the journal, the year of publication, the nation of the Corresponding author, the total times of citation, the citation times per year since publication, and the study type of the papers. The evidence levels of the clinical studies were graded between I to V. The systemic reviews and meta-analyses were combined as a specific type.Results The total citation times of the 100 publications were 27222 and they were cited 18.3 times per year in average. These papers were published in 31 journals in which 13 kinds of journals published more than 2 papers. Corresponding authors came from 17 different nations in which the American authors were the most. The level IV evidence studies were the most as 41 and only 3 papers reached the standards of level I evidence study. The number of the publications decreased obviously after 2009, in which year the two level I evidence publications were published.Conclusion There are still contrary opinions about vertebral augmentation now even after the publications of the two authoritative studies of level I evidence. New studies should be developed with more deliberated design and longer follow-up, meanwhile the patients should be selected more cautious and the evaluation factors should be included more extensively.
One Percutaneous Portal Endoscopic Discectomy in the Treatment of Two-Level Lumbar Disc Herniations Patients with Leg Pain and Numbness
Authors: Yan Denglu , Zhang Zaiheng , Zhang Zhi
Published: September 2020

Background: Although minimally invasive has been adopted in the treatment of lumbar disc herniation, there were no studies in literature of two-level lumbar disc herniations patients with leg pain and numbness treatment by one portal percutaneous endoscopic procedures. The purpose of this study was to evaluate the efficacy of one percutaneous portal transforaminal endoscopic lumbar discectomy techniques in the treatment of two-level lumbar disc herniations patients with leg pain and numbness. Methods: A total of 98 patients of two-level lumbar disc herniations who had one portal endoscopic surgery were categorized into two groups depending on the level number of endoscopic procedures. There were 51 patients had leg pain and leg numbness (A group), and 47 patients with leg pain (B group). One portal percutaneous endoscopic discectomy procedures were performed and the clinical outcomes were recorded. Results: The entry point of two levels disc herniations is planned by parallel to the plane of the proximal disc level and target to the site of distal disc herniation. The procedures in two levels disc herniations was performed beginning at proximal level in L3/4 with L4/5 herniation and distal level in L4/5 with L5/S1. There were no nerve root injury and dural tear of cerebrospinal fluid leakage complications. The postoperative disk and foramen height were no significant difference compare to preoperative in all patients (P > 0.05), and no significant difference between two groups (P > 0.05). The pain index and Oswestry Disability Index score were better than preoperational in all patients, and no significant difference between two groups (P > 0.05). The central disc herniation patients had more leg numbness than lateral disc herniation patients (P < 0.01). For patients with leg pain and leg numbness, the leg numbness release in lateral disc herniation patients were better than central herniation patients, and leg numbness dismissed were 6 months post-operation in lateral herniation patients and 12 months post-operation in central herniation patientsConclusions: Although two-level disc herniation present a significant challenge for spinal surgeon when adopted single portal techniques of endoscopic discectomy, one percutaneous portal transforaminal endoscopic lumbar discectomy was safe and minimally invasive techniques with faster recovery. For patients with leg pain and leg numbness, the central disc herniation patients had more leg numbness than lateral disc herniation patients, and the leg numbness release in lateral disc herniation patients were better than central herniation patients.
Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeleton Remodeling and Suppress EMT
Authors: Chen Xiao , Wang Yutong , Tian Jing , Shao Yurou , Zhu Bo , Wang Jigang , Hua Zichun
Published: September 2020

BackgroundResveratrol (RSV), a cancer chemopreventive natural product, has been shown to affect various cellular processes in tumor cells. However, RSV’s specific protein targets as well as its mechanism of action (MOA) of anticancer effect remain elusive. Recently, quantitative chemical proteomics approach has been an effective tool to identify target proteins, elucidate MOA and predict side effects for active small molecules, especially for natural products.MethodsThe pharmacological activity of RSV was evaluated in A549 cell lines, including the effects on cell proliferation and migration. To elucidate the underlying mechanism, a quantitative chemical proteomics approach was employed to identify the protein targets of RSV. With subsequent in vitro and in vivo experiments, RSV-related pathways and cellular processes were predicted and validated.ResultsRSV significantly inhibited A549 cell migration, but did not affect cell viability. With chemical proteomics approach, 38 target proteins were identified, and proteomic analysis showed that the targets were mainly involved in cytoskeleton remodeling and EMT, which were verified by subsequent in vitro and in vivo assays.ConclusionsRSV inhibits A549 cell migration through binding multiple targets to regulate cytoskeleton remodeling and suppress EMT.
Who will benefit most from lymph node dissection in invasive upper tract urothelial carcinoma: a matched case-control study
Authors: Li Zaishang , Li Xueying , Liu Ying , Xiao Kefeng
Published: September 2020

Background: Limited or regional lymphadenectomy (lymph node dissection, LND), which can help in postoperative risk stratification, is performed with radical nephroureterectomy (RNU). However, the specific ones are appropriate for LND in upper tract urothelial carcinoma (UTUC) has long been debated. We determined the clinical value of LND in different groups of UTUC patients who underwent RNU and someone who benefit most from LND in this study.Methods: Patients diagnosed with UTUC between 2004 and 2015 with available TNM stage classification were identified from 18 Surveillance, Epidemiology and End Results (SEER) registries. Propensity score analysis was used to match the baseline differences of patients. Results: This study included 5426 patients, and 2000 patients with invasive UTUC were matched (1000 patients with LND vs. 1000 patients without LND). The 5-year cancer-specific survival (CSS) estimate for the total cohort was 73.5%. After matching, the LND group had a higher 5-year CSS rate than the no-LND group (77.2% vs. 70.1%, P = 0.002). In heterogeneity analysis, there were significant differences between LND groups and no-LND in stage T4 (52.5% vs. 23.3%, P< 0.001), lymph node metastatic tumors (48.0% vs. 21.2%, P=0.015) and non-distant metastatic tumors (78.5% vs. 71.5%, P = 0.002). According to the most recent pathological prognostic groups classification, significant differences in survival were found between groups only with stage IV tumors (52.0% vs. 25.1%, P< 0.001). However, only stage T4NxM0 tumor patients were found a significant difference between LND groups in subgroup analysis (57.4% vs. 29.9%, P< 0.001). Conclusions:LND may improve the survival of invasive UTUC patients who undergo RNU, especially in T4NxM0 tumor patients. However, this hypothesis requires further confirmation.
Bacterial Distribution and Susceptibility in Bloodstream Infection in Primary-Care Hospital in Nova Friburgo, Rio de Janeiro
Authors: Schimidt Denise Braga , Conde Maria Eduarda Rocha , Silva Nayara de Almeida , Póvoa Helvecio Cardoso Corrêa
Published: September 2020

Human blood is sterile. When there is an infection, microorganisms can reach the bloodstream, which is known as bacteremia. This can be detected by blood culture. To study the prevalence of microorganisms isolated from blood culture samples. One hundred thirty-seven blood cultures were collected from hospitalized patients. All blood samples were processed for culture using a BACT/Alert blood culture machine. Further identification of bacterial pathogens and their antimicrobial susceptibility test were performed using standard microbiological procedures.Among these samples, 20.44% had a positive culture, 60.71% of which belonged to females and 39.29% were from male patients. The most common microorganisms found in positive blood cultures were coagulase negative Staphylococcus (33.33%), Staphylococcus aureus (23.33%), Klebsiella pneumoniae (6.70%), and Escherichia coli (6.66%). One sample showed an ESBL-producing E. coli. Gram-positive microorganisms were 100% susceptible to vancomycin and displayed considerable resistance to oxacillin. Many Gram-negative bacteria were resistant to cephalosporins.
Hypernatremia is common in patients with severe COVID-19 and indicates a poor prognosis
Authors: Sjöström Anna , Rysz Susanne , Sjöström Henrik , Höybye Charlotte
Published: September 2020

Background: Fluid homeostasis, including electrolyte balance, is dependent on an interaction between the renin-angiotensin-aldosterone system (RAAS) and the release of arginine vasopressin from the pituitary. An imbalance can lead to both hypo- and hypernatremia. We investigated the frequency, dynamics and severity of electrolyte imbalance in critically ill patients with COVID-19. Methods: In this retrospective cohort study 223 patients with confirmed COVID-19, treated at the intensive care unit (ICU), were included. Levels of electrolytes, base excess, pH and serum osmolality were collected from the laboratory database. Clinical data was retrieved from patients’ medical records.Results: Hyponatremia was present in 63% of the patients, at admission. Within two weeks of hospitalization, 65% of the patients developed hypernatremia often combined with a rise of base excess. The mortality rate was twice as high in the group with hypernatremia compared to the patients not developing hypernatremia. Treatment of hypertension before the onset of COVID-19 was more common in patients without hypernatremia.Conclusion: Our study shows that hypernatremia is very common in severe COVID-19. Patients that developed hypernatremia needed longer time in ICU and had a higher risk of dying, suggesting that the level of sodium is an important indicator of severity in COVID-19.
Developing and Optimising Observation and Monitoring Guidance for a Paediatric Early Warning System
Authors: Duncan Heather , Emms Karl , Eyre Caron , Hudson Adrienne
Published: September 2020

Background: Hospitalised children experience predictable and potentially preventable life-threatening events in hospital that may be reduced by early warning systems. With the current interest in developing a national PEW system, and in the absence of relevant literature, we present guidance from a mature programme that may be useful to those institutions that are currently planning implementation or modification of an existing system. Objectives: To develop an evidence and expert based observation and monitoring guidance as the standard and recommended practice underpinning a wider Paediatric Early Warning (PEW) system Design: Case study using mixed methods of literature reviews, consultation, focus groups and co-production. Setting: A specialist children’s hospital.Methods: This report outlines the development of the original guidance through consultation and co-production using a literature review and multi-professional focus groups and subsequent iterative changes. Results: The original (2008) and the current (2019) guidance are presented to show the modifications over time including ergonomic chart design, documenting parental concern, continuous monitoring, alarm management, fluid balance and hydration risk assessment, Sepsis 6, conditions to omit and de-escalate observations, and documentation of significant clinical events contemporaneously on the observation chart. Our guidance is compared to the Royal College of Nursing Guidance (2017), which includes good general guidance for performing routine observations correctly, but still limited guidance on the triage/ admission interface, frequency of routine observations, escalation and de-escalation of frequency and type of observations, and specialist observations.Conclusions: We have evolved evidence and expert based observation and monitoring guidance to support the implementation and maintenance of a PEW system over 12 years. The guidance sets standards of care to educate and guide clinicians and provides a template for assessment of that standard of care. TWEETABLE ABSTRACT Evidence and expert based observation and monitoring guidance to support the implementation and maintenance of a Paediatric Early Warning system.
VTR: an algorithm for identifying analogous contacts on protein structures and their complexes
Authors: Pimentel Vitor , Mariano Diego , Cantão Letícia Xavier Silva , Bastos Luana Luiza , Fischer Pedro , Lima Leonardo Henrique França de , Fassio Alexandre Victor , Melo-Minardi Raquel Cardoso de
Published: September 2020

Evolutionarily related proteins can present similar structures but very dissimilar sequences. Hence, understanding the role of the inter-residues contacts for the protein structure has been the target of many studies. Contacts comprise non-covalent interactions, which are essential to stabilize macromolecular structures such as proteins. Here we show VTR, a new method for the detection of analogous contacts in protein pairs. VTR performs structural alignment between proteins and detects interactions that occur in similar regions. To evaluate our tool, we proposed three case studies: (i) we compared a vertebrate myoglobin and a truncated invertebrate hemoglobin; (ii) analyzed interactions between the spike protein RBD of SARS-CoV-2 and the cell receptor ACE2; and (iii) compared a glucose-tolerant and a non-tolerant β-glucosidase enzyme used for biofuel production. The case studies demonstrate the potential of VTR for the understanding of functional similarities between distantly sequence-related proteins, as well as the exploration of important drug targets and rational design of enzymes for industrial applications. We envision VTR as a promising tool for understanding differences and similarities between homologous proteins with similar 3D structures but different sequences. VTR is available at http://bioinfo.dcc.ufmg.br/vtr.
ISLAM NUSANTARA
Authors: Qomar Mujamil
Published: September 2020

This article discusses an Indonesian interpretation of Islam, focusing on the popular concept of Islam Nusantara, the archipelagic Islam. It delves into the account what is Islam Nusantara and the underlying characteristic of the concept. As this article argues, Islam Nusantara reserves as a particular Islamic thought and method. Islam Nusantara is indeed an Indonesian interpretation of Islam that emphasizes on Islam as a cultural phenomenon thus inviting the understanding of religion through a cultural approach. This cultural approach demands pluralities and wasathiyah (moderation) as a main reference for understanding religion. To do so, Islam Nusantara begs inclusive, tolerance and friendly Islamic interpretation and respects differences in terms of cultures and religions. It takes its roots at the Islamic principles of tasamuh, tawazun and i’tidal. Historically speaking, the Javanese nine saints, the Walisongo, is a paradigmatic example in the early Islamic proselytization as translating Islam through cultural.
THE QUR’ANIC COMMUNICATION ETHICS IN SOCIAL MEDIA
Authors: Khasanah Faizatun
Published: September 2020

The politicization of religion in virtual sphere has increased significantly during the election. Political symbols are mobilized to shape public opinion, especially in social media. As a result, social media has become an arena for candidates to contest and get votes as well as political supports. This contestation involves black campaign and hoax. Using a philosophical analysis this article examines ethical values in social media based on Al-Hujarât verses. This article shows that the ethics of communication as mentioned in al-Hujarât verses describe two important points namely the producer of news (communicator) and as the news reader (communicant). Al-Hujarât explains that a communicator has to convey messages in a very sophisticated ways, avoid lowering others, dividing and ruling, circulating hoax, and adjusted to the interlocutor. As communicants need to instill critical thoughts and clarification (tabayyun) towards the truth of the news content.
ISLAMIC PSYCHOTERAPHY AND SOCIAL DISRUPTION
Authors: Suroyya Naharin -
Published: September 2020

This paper uses the perspective of Islamic psychotherapy to examine the development of science and technology and its influence on the changes in adolescent life based on the values of the Qur’an and the Hadi>th. It particularly addresses the practice of Islamic counseling at an Islamic Junior Middle-School, Madrasah Tsanawiyah Negeri/MTsN 4. This article further argues the applicability of Islamic Psychotherapy as a model of overcoming crisis among the students through religious activities. Islamic psychotherapy dictates students to manage mind, emotion and ethics as well as to distance themselves from religiously unlawful acts. A series of collective Islamic rituals performed by students is crucial as a way to cultivate collective belongings, to maintain self-integrity, integrity of the soul and to achieve self-actualization.
“THE SPIRITUAL TURN”
Authors: Sidqi Ahmad
Published: September 2020

This article discusses the philosophical dimension of post-modern societies. It examines the champion of rationalities of modern human beings and contends its contemporary limits. It argues that the modern rational philosophies that over-simplify the meaning “being” in metaphysical form has led to the civilizational crisis. In religious dimension, modern human has been sacrificing their inner spiritual dimension of humanity. As a response to this crisis, modernity has initiated the birth of “spiritual turn” that modern human tries to reinvent their spirituality, mainly through Islamic Sufism. This article further examines the significance of Sufi concepts of the 14th century Sufi master Ibn Atha`illah (1259-1310). Examining his Sufi concepts from the lights of post-modern philosophy as panacea for modern diseases, this article found that the concept of spiritual knowledge (ma’rifat) is an essential concept as transcending the limits of rationality and materiality of modern philosophy
FORMULATING THEORIES OF DAKWAH STUDIES
Authors: Syam Nur
Published: September 2020

This paper examines the contribution of sociology to the making of Dakwah studies. From epistemological point of view, dakwah studies develops through five elements: factors, systems, interpretative, developmentalism and participatory. These five elements can be developed based on sociological theories. Through a sociological approach, dakwah studies will be able to contribute to general discussion on the sociology of Muslim societies. The article further argues the inclusion of social science is a pattern of knowledge development based on the integration of science, namely the phenomenon of dakwah as an object of study, while utilizing other social science as approaches.
Apresentação
Authors: Lima Clóvis Ricardo Montenegro de
Published: September 2020

Apresentação.
Expediente
Authors: Lima Clóvis Ricardo Montenegro de
Published: September 2020

Expediente.
Bibliotecas escolares e tecnologias digitais
Authors: Neves Bárbara Coelho , Sampaio Denise Braga , Rodrigues Quézia
Published: September 2020

Trata da biblioteca escolar dentro do âmbito das tecnologias digitais de informação e comunicação (TDIC). Tem por questão orientadora como os estudos na área de Biblioteconomia compreendem o uso das tecnologias digitais pelas bibliotecas escolares, nos últimos dez anos. A partir deste questionamento, objetiva analisar as produções acadêmicas a respeitos das tecnologias digitais na biblioteca escolar, categorizando tais produções segundo suas especificidades, que foram amparados por pesquisa exploratória, bibliográfica, com levantamento na Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e abordagem quanti-qualitativa dos dados. Os resultados mostram que ainda são poucas as produções que abordam sobre as interações entre a biblioteca escolar e as TDIC. Conclui-se, assim, que deve ser dada uma maior atenção a esse tema.
Inovação na Educação
Authors: Canto Cleunisse Aparecida Rauen De Luca , Bastos Rogério Cid , Rengel Denise Maria
Published: September 2020

Este estudo compara os resultados obtidos na aplicação de questionário sobre estilos de aprendizagem com achados da literatura, e correlaciona com as estratégias de ensino. Utilizamos os estudos obtidos na revisão realizada por Canto e Bastos (2019); aplicamos um questionário VAK (visual, auditory, kinesthetic) em 110 docentes-estudantes de uma pós-graduação e, na sequência, em 756 estudantes de diferentes modalidades; e comparamos os resultados obtidos. Dos 10 artigos selecionados, utilizaram instrumento de avaliação e focaram no padrão VAK, ou no VARK (incluindo aural-Read), no qual em 70% deles a preferência foi pelos estilos visual e cinestésico. Nesse estudo, 95% dos docentes-estudantes avaliados, e 80% nos demais estudantes, também demonstraram preferência pelos estilos visual e cinestésico. Concluímos que os estilos de aprendizagem permitem aos alunos identificar pontos fortes e fraquezas ao aprender, e aos professores definir as suas metas e estratégias de ensino para que consigam projetar atividades centradas no aluno.
Contribuição do Portal de Periódicos da Capes para a produção científica dos pesquisadores brasileiros no campo do Direito
Authors: Gomes Eliane , Oddone Nanci
Published: September 2020

Os conceitos de política de informação e de ciclo de políticas públicas oferecem suporte à constatação de que o Portal de Periódicos da Capes representa o instrumento de uma política pública de acesso à informação científica que modificou o regime de informação até então vigente. Nesse contexto, para avaliar a legitimidade dessa mudança política que afetou diretamente as funcionalidades da comunicação científica no país, o presente estudo fez uso de técnicas bibliométricas com o objetivo de aferir qual foi a contribuição dos periódicos estrangeiros assinados pelo Portal na área do Direito para a produção dos pesquisadores brasileiros dessa área. A população da pesquisa envolveu os docentes permanentes dos Programas de Pós-Graduação em Direito que obtiveram notas 4, 5 e 6 na Avaliação Trienal de 2013. Sua produção foi examinada, incluindo os artigos científicos publicados no exterior, e todas as citações a artigos estrangeiros foram extraídas, formando uma listagem de títulos estrangeiros que em seguida foi comparada com a listagem de títulos assinados pelo Portal visando definir indicadores de demanda versus oferta de títulos. Os resultados mostraram que os pesquisadores da área do Direito utilizaram apenas 7,6% dos títulos estrangeiros disponíveis no Portal, investindo mais em títulos com acesso aberto e em formato impresso.
Aprendizagem e interação na rede social Facebook
Authors: Cristina Falcão Soares Rodrigues Geovanna , Gusmão de Góes Brennand Edna
Published: September 2020

Este artigo tem como objeto de estudo as interações que ocorrem nos sites de rede sociais, com o objetivo de analisar como as diferentes formas de interações ocorridas nos sites de redes sociais estão relacionadas a aprendizagens. Os dados foram coletados através da rede social Facebook a partir de postagens em seis páginas da referida rede social e analisados por meio das técnicas de análise de redes sociais e de análise de conteúdo, com auxílio de softwares. Os resultados encontrados apontaram que os sites de redes sociais, ao oferecer aos usuários diferentes possibilidades de interação e estimulam as redes de aprendizagens em suas dimensões cognitiva, afetiva e vivencial. As interações se relacionam a aprendizagens quando – através das postagens, compartilhamentos, comentários e reações – possibilitam que as pessoas dividam conhecimento, dialoguem, produzam conteúdo e expressem sentimentos e percepções, em uma rede infinita de possibilidades.
Çanakkale İlinde Kara Avcılığı ve Yöre Ekosistemine Etkileri
Authors: Ilgar Rüştü
Published: September 2020

Çanakkale ili ülkemizin kuzeybatı bölümünde adıyla anılan bir boğazın iki yakasında toprakları bulunan ve ülkemizin en büyük adalarından ikisine sahip bir ildir. Akdeniz ve Karadeniz iklimlerinin birbirine yaklaştığı Marmara geçiş iklimi özelliklerine sahip il topraklarının %54’ü ormanlarla kaplıdır. Ayrıca farklı topografya şekillerine sahip olması il genelindeki flora ve faunanın çeşitlenmesine sebep olmuştur.
Çeşitli hayvan ve bitki türlerine ev sahipliği yapması Çanakkale’nin av potansiyelini de artıran bir durum olarak karşımıza çıkmaktadır. Nitekim il göç yolları üzerinde bulunması sebebiyle ülkemizdeki kuş türlerinin 1/3’üne ev sahipliği yapmaktadır. Bunun sonucu olarak da il genelinde 36 adet genel avlak ve devlet avlağı, 3 adet örnek avlak, 5 adet özel avlak ve 3 adet yaban hayvanı yerleştirme sahası bulunmaktadır. İldeki avcılık faaliyetleri kapsamında kayıtlı 513 avcı, 874 adet ruhsatlı av tüfeği ile faaliyet göstermektedir. Bu derece yoğun av faaliyetinin yapılması il genelindeki tür çeşitliliği üzerinde baskı oluşturmakta, sürdürülebilir av turizminin uygulanmasını güçleştirmekte ve bölge ekosistemi üzerinde çeşitli tahribatlara yol açmaktadır. Bu çalışmada Çanakkale İlindeki kara avcılığı ve bölge ekosistemi üzerindeki etkileri bilimsel metotlarla çevreci bakış açısıyla değerlendirilmiş, sonuçlar ve çözüm önerileri ortaya konulmuştur.
Computation of Improved Searls Estimation of Population Variance Using Robust Auxiliary Parameters
Authors: Yadav S. K. , Sharma Dinesh K. , Alade Julius A.
Published: September 2020

:

Variation is an inherent phenomenon, whether in natural things or man-made. Thus, it seems essential to estimate this variation. Various authors have worked in the direction of improved estimation of population variance utilizing the known auxiliary parameters for better policymaking.

Methods:

In this article, a new Searls ratio type class of estimator is suggested for elevated estimation of population variance of the main variable. As the suggested estimator is biased, its bias and mean squared error (MSE) has been derived up to the order-one approximation. The optimum values for the Searls characterizing scalars are obtained. The minimum MSE of the introduced estimator is obtained for the optimum Searls characterizing scalars. A theoretical comparison between the suggested estimator and the competing estimators has been made through their mean squared errors. The efficiency conditions of the suggested estimator over competing estimators are also obtained. These theoretical conditions are verified using some natural data sets. The computation of R codes for the biases and MSEs of the suggested and competing estimators is developed and used for three natural populations in the study by Naz et al. The estimator with the least MSE is recommended for practical utility. The empirical study has been done using R programming.

Results:

The MSEs of different competing and the suggested estimators are obtained for three natural populations. The estimator under comparison with the least MSE is recommended for practical applications.

Discussion:

The aim to search for the most efficient estimator for improved estimation is fulfilled through the proper use of the auxiliary parameters obtained from the known auxiliary variable. The suggested estimator may be used for elevated estimation of the population variance.

Conclusion:

The introduced estimator has the least MSE as compared to competing estimators of population variance for all three natural populations. Thus, it may be recommended for application in various fields.
KIRSAL YOLLARIN ÜSTYAPI PERFORMANS ANALİZİNDE COĞRAFİ BİLGİ SİSTEMLERİNİN KULLANILABİLİRLİĞİ: ISPARTA ÖRNEĞİ
Authors: TERZİ Serdal , AHMED Melak Hussein
Published: September 2020

Düzgünsüzlük indeksi yolların performansı hakkında önemli bilgi veren bir parametredir. Düzgünsüzlüğün önceden tahmin edilebilmesi, yolların bakım ve onarım planlamaları için büyük bir kolaylık sağlayabilir. Bu çalışma kapsamında sathi kaplamalı yolların gelecek yıllarda sahip olması beklenen uluslararası düzgünsüzlük indeksi (IRI) değeri tahmin edilmiştir. Bu amaçla, kırsal yollar için trafik hacmi ve iklim verileri ile literatürde geliştirilmiş olan lineer denklemler amaç fonksiyonu olarak kullanılmıştır. Ek olarak tahmin edilen IRI değerleri ve ilgili yol kesimi hakkındaki trafik hacim ve bölge iklim verileri Coğrafi Bilgi Sistemlerine işlenmiş ve optimizasyon çalışması gerçekleştirilmiştir. Gerçekleştirilen 5 yıllık örnek bir uygulama ile coğrafi bilgi sistemlerinin, kırsal yollarda üstyapı yönetim sistemi için kullanılabilirliği gösterilmiştir.
Enabling Remote Patient Monitoring Through the Use of Smart Thermostat Data in Canada: Exploratory Study
Authors: Sahu Kirti Sundar , Oetomo Arlene , Morita Plinio Pelegrini
Published: September 2020

Background

Advances in technology have made the development of remote patient monitoring possible in recent years. However, there is still room for innovation in the types of technologies that are developed, used, and implemented. The smart thermostat solutions provided in this study can expand beyond typically defined features and be used for improved holistic health monitoring purposes.

Objective

The aim of this study is to validate the hypothesis that remote motion sensors could be used to quantify and track an individual’s movements around the house. On the basis of our results, the next step would be to determine if using remote motion sensors could be a novel data collection method compared with the national census-level surveys administered by governmental bodies. The results will be used to inform a more extensive implementation study of similar smart home technologies to gather data for machine learning algorithms and to build upon pattern recognition and comprehensive health monitoring.

Methods

We conducted a pilot study with a sample size of 8 to validate the use of remote motion sensors to quantify movement in the house. A large database containing data from smart home thermostats was analyzed to compare the following indicators; sleep, physical activity, and sedentary behavior. These indicators were developed by the Public Health Agency of Canada and are collected through traditional survey methods.

Results

The results showed a significant Spearman rank correlation coefficient of 0.8 (P<.001), which indicates a positive linear association between the total number of sensors activated and the total number of indoor steps traveled by study participants. In addition, the indicators of sleep, physical activity, and sedentary behavior were all found to be highly comparable with those attained by the Public Health Agency of Canada.

Conclusions

The findings demonstrate that remote motion sensors data from a smart thermostat solution are a viable option when compared with traditional survey data collection methods for health data collection and are also a form of zero-effort technology that can be used to monitor the activity levels and nature of activity of occupants within the home.