bluuebunny/crossref_metadata_2025 huggingface dataset:
Anton Krempl in etnične identitete na Štajerskem v 19. stoletju
Authors: Ditmajer Nina
Published: July 2021

V prispevku so predstavljena različna obdobja Kremplovega bivanja in delovanja na vzhodnem Štajerskem ter osvetljeni nekateri pomembni dogodki, ki so vplivali na obli-kovanje njegove etnične identitete. Na njegovo začetno ideološko formiranje je najbolj vplivalo šolanje v Gradcu, dokončno pa izoblikovalo v času službovanja pri Mihaelu Jaklinu. Kasneje je bil tudi on naklonjen panslavizmu, politični ilirizem Ljudevita Gaja pa je zavračal.
Štajerske razglednice – s posebnim pogledom na Antona Krempla v slikovnem gradivu UKM
Authors: Kolbič Gabrijela
Published: July 2021

Prispevek predstavlja vizualni pregled krajevnih postaj iz življenja in delovanja An-tona Kremplja, ki ga v slikovni podobi na razglednicah hrani Zbirka drobnih tiskov v Univerzitetni knjižnici Maribor. V zbirki je danes za raziskovanje in prezentacijo na voljo preko 55.000 razglednic domačih krajev in tujine. Z njihovim izborom sledimo življenjski poti Antona Krempla, in sicer od Radgonskih goric, kjer se je 1790 na Poličkem vrhu pri Gornji Radgoni rodil, do krajev šolanja (Gornja Radgona, Maribor, avstrijski Gradec) in delovanja v Svetinjah pri Ljutomeru, Ormožu, Ptuju, Sv. Lovrencu v Slovenskih goricah in nazadnje pri Mali Nedelji. Izbor razglednic štajerskih krajev tako predstavlja gradivo iz zbirke, ki ilustrativno oriše Kremplovo biografsko pot.
Wojsko w zmaganiach z naturą w świetle kronik Anonima tzw. Galla i Mistrza Wincentego zwanego Kadłubkiem
Authors: Ćwikła Łukasz
Published: July 2021

The components of natural environment were suitable for defending the points of resistance or surprising the enemy. However, it is important to say that without a well prepared defense they were useless. For instance the role of forests wastwofold taking into account leading the great campaigns or even smaller skirmishes. The main issue of this article is to follow the army’s struggle with nature during marching and warfare (the aggression against Bohemia, Prussia and battles in the country) including its impact on both successes and defeats according to the chronicles of Anonym called Gall and Master Wincenty called Kadłubek.
Od Lexington do Trenton. Kilka refleksji na temat żywiołu wody i jego wpływu na działania wojsk w pierwszych latach walki o amerykańską niepodległość
Authors: Daszyńska Jolanta A.
Published: July 2021

The battle of Lexington, 1775 started the American War of Independence. The Continental Army was raised by the Second Continental Congress on June 14, 1775 and two days after it fought in the first battle, known as the battle of Bunker Hill (June 17, 1775). George Washington was appointed as the Commander-in-Chief. He did not took part in it, staying already at Philadelphia. The British Pyrrhic victory caused the break in the fights till the Spring of 1776. In March because of a strong flury the British troops could not to attack, and as a result they left Boston on March 17. This day is celebrated as an Evacuation Day. While General Washington, with the American Army, was blockading the British garison in Boston, the other troops led the attack to invade Canada. They attacked from two maine rivers: The St. Lawrence River and St. Charles River. But the wide and ice covered rivers caused the big problem with transportation of soldiers. This time a snowstorm stopped the American attack, and they withdrew from Canada. The disastrous defeat of the Americans in the battle of Long Island on August 27, 1776 was the first battle after the Proclamation of Independence which led to the loss of New York and retreat to the Delaware River. Heavy rain was a non-attack factor. Among the presented battles, some of them were victories, but some were the defeats of the American soldiers. The nature and the elements of cold, frost, rains, snowstorms, icy roads and ice-covered rivers were not the ally for attacking troops. But sometimes, such an extreme weather conditions led to success, as it was during the battle of Trenton, after Washington’s famous crossing the Delaware River. The image on it is the best known battle picture in the world.
Amerykańskie wojska inżynieryjne w konflikcie wietnamskim 1964–1975
Authors: Pietrygała Robert , Cutter Zdzisław
Published: July 2021

The article focuses on the period of the Vietnam War, with particular emphasis on the role played by engineering troops (as a necessary component of individual tactical associations, and a guarantee of success of military operations conducted by the US army). The paper presents the engineering troops’ efforts to build military infrastructure, as well as the assistance provided to the South Vietnamese society. The article contains a list of all engineering units of the American army involved in the Vietnamese conflict, their organizational structure, personnel status, dislocation, as well as the scope of tasks assigned to them. In addition, it shows the cooperation between engineering units and civil contractors at the service of the army (especially in the period preceding the direct involvement of the United States in the war).
Character Association and Path Coefficient Analysis of Certain Biometrical Traits among Fenugreek Genotypes under Different Environmental Conditions
Authors: Singh Shyam , Singh Bhuri
Published: July 2021

Background: Fenugreek is grown under various agro-climatic conditions of the world as well as in India. However, overall yield and quality depends upon various quantitative characters that exist during crop growth period. Therefore, this study aimed to find out the character association and path coefficient analysis among the seed yield and yield contributing characters in fenugreek genotype. Methods: Thirty genotypes were sown with three replications under two environments namely normal (E1) and limited (E2) irrigation conditions during Rabi season 2019-20. The experiment was laid down in RBD. Result: The genotypic and phenotypic correlations were exhibited significantly positive for number of pods per plant (0.765, 0.725 and 0.670, 0.651), number of seeds per pod (0.705, 0.650 and 0.666, 0.640) and pod length (0.376, 0.348 and 0.351, 0.327) with seed yield per plant in both the environments i.e. E1 and E2. The highest direct effect on seed yield per plant was observed for number of pods per plant (0.693, 0.602 and 1.030, 0.754), number of seed per pod (0.396, 0.378 and 0.490, 0.421) and test weight (0.338, 0.304 and 0.405, 0.368) at genotypic and phenotypic levels in both environments i.e. E1 and E2.
Evaluation of Surf Field Mastitis Test (SFMT) For the Detection of Subclinical Mastitis in Dairy Cows
Authors: Karabasanavar Nagappa , Manjunatha L. , Jeevan M.N. , Naveenkumar G.S.
Published: July 2021

Background: Subclinical mastitis (SCM) continues to be one of the major economic diseases of dairy animal. For effective management of SCM prompt early detection is required at the field level. Present study deals with evaluation of Surf Field Mastitis Test (SFMT) - the cow side, on-farm and field level SCM detection test and its comparison with established tests. Methods: Holstein Friesian and Jersey crossbred dairy cows quarter milk (n=72) were tested for SCM using California Mastitis Test (CMT) and somatic cell count (SCC). Result: In comparison, CMT showed higher inclusivity and negative predictivity; while, SFMT had higher exclusivity and positive predictivity. Nevertheless, both CMT and SFMT tests performed equally in the detection of SCM as measured by analytical accuracy (84.72%). In comparison to the SCC, both CMT and SFMT showed strong concordance (kappa value of 0.7 agreements each). However, between CMT and SFMT moderate agreement was observed (kappa value 0.58). Further, in comparison to SCC, SFMT showed higher diagnostic sensitivity of 94.74% than the CMT 73.68%; specificity of CMT was higher (97.06%) than the SFMT (73.53%). Results of the present study indicated practical applications of SFMT for the detection of SCM owing to accessibility and ease of doing SFMT and its diagnostic capabilities in comparison to the widely accepted CMT. Keeping in view, the economic significance of SCM among crossbred dairy cows and need for its early diagnosis at the field level; findings of this study recommend popularization of SFMT among dairy farmers so as to control SCM in time and avoid associated economic losses to the dairy farmers.
Cytology and Radiology as a Diagnostic Tool to Detect Metastasis in Mammary Tumor Affected Dogs
Authors: Prabhakaran K.P. , Balasubramaniam G.A. , Madheswaran R. , Raja A. , Kumerasan A.
Published: July 2021

Background: Malignant mammary gland tumors can metastasize to various organs; of which, lungs and regional lymph nodes are most frequently affected. Chest radiographs and regional lymph node FNAs are important diagnostic tool to detect metastasis as per oncology practice guidelines. The present study was aimed to develop suitable diagnostic tool to detect metastasis in mammary tumor affected dogs. Methods: Between September 2017 to July 2018, thirty three dogs (n=33) affected with mammary tumors were included in the study. Out of thirty three dogs, three dogs (n=3) showed swollen regional lymph nodes and pulmonary metastases. Different parameters such as haematology, serum biochemistry, radioimmunoassay, radiology, cytology, histopathology and immunohistochemistry were analysed. Result: TNM clinical staging revealed that all the three dogs showed stage IV tumors which were usually malignant and showed frequent metastases. Haematological abnormalities such as anemia, leucocytosis and reduced platelet count were noticed. Serum biochemistry showed reduced protein and electrolyte level with elevated alkaline phosphatase and alanine transaminase. Radioimmunoassay showed many-fold elevation of estradiol and progesterone. Radiography of lungs revealed severe pulmonary metastasis. Cytological examination of swollen accessory lymph node revealed mixed population of lymphocytes and neoplastic cells. Grossly, the lymph nodes were found to be enlarged, blood tinged and covered with subcutaneous adipose tissue. Histopathology of tumor masses from three dogs revealed cystic papillary carcinoma, ductal carcinoma and anaplastic carcinoma. Immunohistochemistry revealed that dogs were affected with triple negative tumors which were highly malignant, poor prognosis and not responding to therapy.
Chemopreventive Effect of Stoechospermum marginatum against Experimental Colon Carcinogenesis Induced by 1, 2-Dimethyl Hydrazine
Authors: Kalaiselvi L. , Sriram P. , Gokulakannan R. , Parthiban M. , Kannan T.A. , Preetha S.P. , Vijayarani K. , Pazhanivel N.
Published: July 2021

Background: Colon cancer is the one most prevalent malignancy in the world and its incidence is increasing due to changing life styles, environmental factors, etc. Conventional chemotherapy for cancer is limited due to development of chemoresistance and severe side effects. Natural products have received great attention in the recent years owing to its reduced toxicity and side effects. The present was undertaken to evaluate chemopreventive potential of ethanolic extract of Stoechospermum marginatum in experimentally induced colon carcinogenesis in rats. Methods: Healthy male wistar rats were divided into 6 groups and received following treatments: Vehicle (Group I); S. marginatum extract (Group II), DMH alone (Group III), DMH + 5-Fluorouracil (Group IV), DMH +S. marginatum extract at 100 mg/kg (Group V) and DMH +S. marginatum extract at 200 mg/kg (Group VI). Colon tumour was induced using 1, 2-dimethylhydrazine (DMH). Result: S. marginatum extract ameliorated oxidative damaging effects of DMH. S. marginatum extract increased expression of Bax, caspase 3 and caspase 9; decreased expression of Bcl-2 and restored levels of COX-2 compared to tumor control. Reduced aberrant crypt foci, hyperplastic and inflammatory changes in colon were observed with S. marginatum compared to tumour control. The findings suggest chemopreventive potential of S. marginatum.
Principales factores que permitieron la internacionalización de las franquicias peruanas al mercado latinoamericano durante el periodo 2013-2018
Authors:   , Meoño Santiváñez Luis Renato , Tuesta Caro Rodrigo Alfonso
Published: July 2021

En los últimos años, el comercio internacional ha tomado el protagonismo debido a que ha mostrado tener gran potencial de expansión hacia los años siguientes, este fenómeno no ha sido ajeno en Latinoamérica y el Perú en general. En los años 2011 – 2018 la exportación de servicios mostró un crecimiento promedio anual de 7% en la región y en el Perú ha sido de 9%, en comparación del 4% de las exportaciones de bienes. Entre los servicios exportados por el Perú, se encuentran las franquicias como un servicio que ha tenido gran acogida a nivel Latinoamérica. Para ello, para la presente investigación se propuso descubrir ¿Cuáles fueron los factores críticos que permitieron a las franquicias peruanas ingresar a mercados latinoamericanos durante el periodo 2013-2018?, en la cual, por medio de una investigación de tipo cualitativo y exploratorio, se desarrollaron los factores push y pull para conocer los factores críticos que se llevaron a cabo por los actores del mercado. Por medio de entrevistas estructuradas a expertos, se encontró en cuanto a factores push, una escasa participación e impulso por parte de entidades gubernamentales para la exportación de franquicias; sin embargo, por su parte los factores pull como la “proximidad geográfica” y la “similitud cultural y de idioma”, son factores que han facilitado el ingreso de las franquicias peruanas al exterior.
Factores que limitan las exportaciones de joyería de plata peruana hacia el Reino Unido en el marco del TLC Perú-UE
Authors:   , Laureano Espichan Mariela Estefania , Maraví Chiesa Mayra Alejandra
Published: July 2021

Actualmente, el Perú es el segundo productor y exportador de plata a nivel mundial. Sin embargo, según las estadísticas oficiales de la Asociación de Exportadores (ADEX, 2018), del total de extracción de materia prima solo el 1% es destinado al sector joyería, un monto significativamente menor si es comparado con el 15% que destina México siendo el principal extractor de plata del mundo. De acuerdo con dicha asociación, al cierre del 2018 las exportaciones peruanas de joyería alcanzaron los 127 millones de dólares, monto mayor en 4.8 % respecto al 2017, siendo el mercado estadounidense el que concentra el 87.2 % del total de los envíos de joyas peruanas al exterior en 2018, según las cifras oficiales del gremio exportador. Dentro de la lista de los principales países destino de nuestras exportaciones de joyería de plata se encuentran México, Austria, Costa Rica, Canadá y Reino Unido. Para entender la importancia e impacto potencial de este sector en la economía de nuestro país, es necesario considerar que la industria joyera genera más de 50 000 puestos de trabajo en el Perú entre directos e indirectos según Domínguez (2018). La presente investigación tiene por finalidad analizar los factores que influyeron en las exportaciones de joyería de plata peruana (NCM 7113110000) hacia el Reino Unido durante los años 2013 – 2018 en el marco del TLC Perú-Unión Europea. El desarrollo de la investigación se presentará en cinco capítulos que contienen información cuantitativa y cualitativa tomada de fuentes confiables del mercado tanto a nivel nacional como internacional. En el primer capítulo se explicarán los antecedentes epistemológicos y el marco teórico. Para empezar, se presentarán conceptos que ayuden a entender el objetivo de estudio de la investigación y posteriormente se analizarán las investigaciones previas existentes. En el segundo capítulo se planteará el problema de la investigación, los objetivos e hipótesis. Asimismo, se mencionará la justificación del tema elegido y también las limitaciones propias de la investigación. Para la presente tesis se ha optado por desarrollar un objetivo general y 5 objetivos específicos. En el tercer capítulo se presentará el marco metodológico ha utilizar para el desarrollo de los objetivos propuestos. Se dará mayor detalle de la selección de la muestra, el instrumento ha utilizar y se definirá el enfoque de la investigación. En el cuarto capítulo se explicará el desarrollo, el análisis de los objetivos y las validaciones de las hipótesis formuladas previamente. Luego, en el capítulo cinco se presentará la discusión de los resultados del estudio por cada objetivo planteado. Finalmente se mencionará las conclusiones de la investigación y las recomendaciones.
A comunidade do não-lugar: William Morris e utopias passadas e futuras
Authors: Fouto Rafael Silva
Published: July 2021

Este artigo analisa a relação de duas obras de baixa ficção científica de William Morris (1834-1896), A Dream of John Ball (1888) e News from Nowhere (1890), comparando-as com os conceitos de comunidade, imunidade, arte e revolta conforme explorados por filósofos como Jean-Luc Nancy, Roberto Esposito, Jacques Rancière e Furio Jesi. William Morris foi um socialista, designer têxtil e escritor inglês durante o período vitoriano, fundador da Socialist League na Inglaterra; os romances aqui explorados trabalham com visões oníricas de potenciais comunidades socialistas ou proto-socialistas, tanto no futuro quanto no passado, e como tais comunidades seriam aos olhos de um viajante temporal inglês do período de Morris. Com base na comparação com diversos filósofos contemporâneos, percebe-se a afinidade do autor com a perspectiva de uma comunidade que rompe com pressupostos e limites bem definidos, sendo por necessidade utópica e inspiradora.
El tratamiento de la temática padre e hijo en cuentos de Borges y Rulfo
Authors: Botoso Altamir
Published: July 2021

Un mismo tema permite tratamientos distintos y variadas interpretaciones. Las relaciones entre padres e hijos, por ejemplo, se llenan de significados y símbolos matizados por aspectos realistas, fantásticos o mágicos en el ámbito literario. Basados en estas ponderaciones, en este artículo, nuestra propuesta es analizar los cuentos “Las ruinas circulares” del escritor argentino Jorge Luis Borges y “No oyes ladrar los perros” del mexicano Juan Rulfo, a partir de una mirada comparatista, destacando el modo como estos dos autores exploran el tema de las relaciones entre padres e hijos en la ficción. Borges se vale de lo fantástico para tratar la cuestión de paternidad en el cuento, mientras Rulfo se utiliza del realismo para poner de relieve el dolor y la desesperanza de padre e hijo en tierras latinoamericanas. El aporte teórico se basa en los estudios críticos de Sainz Borgo (2018), Sánchez Quintana (2016), Díez R. (2016), Gnutzmann (1972), Katra (1990), Lasarte (1989), Oviedo (2012), Vargas (2003).
Nomeações e significações da homossexualidade masculina: um ensaio sobre homofobia pela ótica da Teoria das Representações Sociais
Authors: Mendes Augusto César Cardoso , Ribeiro Luiz Paulo
Published: July 2021

A violência homofóbica tem se caracterizado como um problema social. Essa forma de violência pode se caracterizar na forma de xingamentos, nomeações ofensivas e que expressem desqualificação. Neste estudo, nos debruçamos sobre as nomeações que homossexuais masculinos (homens gays) recebem socialmente, com ênfase na nomeação “viado”. Para esta análise, acionamos a Teoria das Representações Sociais para compreender a aplicação dessas expressões frente as questões históricas, nas quais é comum encontrar fatos que dizem respeito a desvalorização e violência para com os sujeitos não heteroafetivos e não cisgêneros. A construção teórica do texto foi baseada em uma pesquisa bibliográfica, que teve como finalidade reunir outras produções científicas que já tangenciaram a temática. O trabalho evidenciou que algumas representações sociais sobre a homossexualidade podem favorecer a homofobia
Expanded Universes in Science Fiction: A Matter of Integration
Authors: Baby Gomes Arthur Maia , Indrusiak Elaine Barros
Published: July 2021

Still lacking theoretical definitions, expanded universes are an artistic phenomenon often seen in science fiction literature as well as in narratives in other media. This text proposes a mechanism to explain how these universes come into being. For this, we analyze a series of cases such as Robert A. Heinlen’s Future History, Ursula K. Le Guin’s Hainish Cycle, George R. R. Martin’s Thousand Worlds, Joanna Russ’ Whileaway, and transmedia examples such as the Marvel Cinematic Universe. Borrowing from Tamar Yacobi’s concept of mechanisms of integration – ways in which the reader makes sense of inconsistencies or oddities in a narrative – we argue that the explanation that two or more independent stories are set in a common universe is a hypothesis generated by the reader to integrate coincidences between these stories
What is the impact of staff wearing uniforms in psychiatric inpatient settings?
Authors: Collingwood Sophie , McKenzie-Smith Laura
Published: July 2021

Background: Uniform has traditionally been worn in psychiatric inpatient and other mental health settings, but there has been a move to non-uniform in recent years. Some services have made the change back to uniform, raising questions about the potential impact on patients and
staff.
Aim: To review the impact of uniform within a psychiatric inpatient or mental health setting.
Method: Databases were searched for articles exploring the impact of uniform use using specified search terms. Articles were assessed for suitability with
inclusion and exclusion criteria, critically appraised, then analysed for themes using thematic analysis.
Results: 17 papers were included in the review. Thematic analysis identified five main themes and 29 subthemes. Main themes were Attitudes and interactions, A
freer environment, Are you both nurses?, The 'ideal self' and There are more important things. A critical appraisal of the articles suggested issues with validity and reliability, which are discussed.
Discussion: Studies identified that wearing non-uniform
facilitated positive changes in both patients and staff. This raises the potential negative impact of uniform on both patients and staff, and the role of power imbalance in these settings is discussed. Further themes around identification of staff out of uniform were considered.
Implications
for practice: The use of uniform in mental health and psychiatric inpatient settings should be considered carefully, due to the potential negative impact, whilst also recognising the importance of staff identification and supporting professional identity.
The use of virtual reality in a psychiatric intensive care unit: a pilot study
Authors: Mark Isabel , Bell Darren , Kirsh Leiah , O'Brien Aileen
Published: July 2021

With online options becoming increasingly popular within healthcare, virtual reality (VR) is a rapidly emerging field. This study assessed the feasibility and tolerability of using a VR headset in a psychiatric intensive care unit (PICU). Inpatients were invited to watch VR videos under
supervision. 25 patients were considered, with 21 meeting the inclusion criteria and 17 taking part. All 17 participants were able to tolerate the VR and all reported it as a positive experience; 16 (94.1%) stated they would like to repeat the process; 3 (17.6%) reported an adverse effect
and 2 (11.8%) reported an aspect which was not liked.
 We demonstrate that VR can be used and tolerated within the high-stress environment of a PICU. Further investigation is now needed to assess potential therapeutic benefits for agitation and psychotic symptoms in PICU.
In Vitro and In Vivo Evaluation of Human Adenovirus Type 49 as a Vector for Therapeutic Applications
Authors: Bates Emily A. , Counsell John R. , Alizert Sophie , Baker Alexander T. , Suff Natalie , Boyle Ashley , Bradshaw Angela C. , Waddington Simon N. , Nicklin Stuart A. , Baker Andrew H. , Parker Alan L.
Published: July 2021

The human adenovirus phylogenetic tree is split across seven species (A-G). Species D adenoviruses offer potential advantages for gene therapy applications, with low rates of preexisting immunity detected across screened populations. However, many aspects of the basic virology of species D, such as their cellular tropism, receptor usage and in vivo biodistribution profile, remain unknown. Here, we have characterized human adenovirus type 49 (HAdV-D49), a relatively understudied species D member. We report that HAdV-D49 does not appear to use a single pathway to gain cell entry but appears able to interact with various surface molecules for entry. As such, HAdV-D49 can transduce a broad range of cell types in vitro, with variable engagement of blood coagulation FX. Interestingly, when comparing in vivo biodistribution to adenovirus type 5, HAdV-D49 vectors show reduced liver targeting whilst maintaining transduction of lung and spleen. Overall, this presents HAdV-D49 as a robust viral vector platform for ex vivo manipulation of human cells and for in vivo applications where the therapeutic goal is to target the lung or gain access to immune cells in the spleen whilst avoiding liver interactions, such as intravascular vaccine applications.
Analysis of the Behaviour of Rocks Under Cyclic Loads
Authors: Cardu Marilena , Saltarin Simone , Todaro Carmine
Published: July 2021

The cyclic load applied to civil and mining structures can lead to a reduction of the materials’ strength, different from that which would occur with a monotonous load. Numerous cases can be found where the decay of the rock parameters subjected to this type of stress leads to progressive or sudden collapse: among them, tunnel walls, pillars and slabs in mining operations, roads with a heavy vehicle transit, abutments of bridges and dams can be quoted. The topic can therefore be fundamental for a correct structural design, to avoid problems during the life of the structure. However, given the heterogeneity of the rock materials and the difficulty of their characterization under this aspect, an unequivocal analysis is hardly achievable. Then, the discussion initially develops through a general historical review of the concept of fatigue, with a synthetic collection of case histories. The laboratory tests on rock samples are then examined and the most important results obtained are discussed. Finally, a comparison between different types of tests is proposed. The experimental data are expressed through the Wӧhler diagram. The goal is to fill the lack of design codes or standards in the field of cyclic stresses applied to rock materials, the understanding of its effect being of great interest in order to apply suitable parameters in the design phase.
Ontology of a Wavefunction from the Perspective of an Invariant Proper Time
Authors: Yasmineh Salim
Published: July 2021

All the arguments of a wavefunction are defined at the same instant implying a notion of simultaneity. In a somewhat related matter, certain phenomena in quantum mechanics seem to have non-local causal relations. Both concepts are in contradiction with special relativity. We propose to define the wavefunction with respect to the invariant proper time of special relativity instead of standard time. Moreover, we shall adopt the original idea of Schrodinger suggesting that the wavefunction represents an ontological cloud-like object that we shall call ‘individual fabric’ that has a finite density amplitude vanishing at infinity. Consequently, measurement can be assimilated to a confining potential that triggers an inherent non-local mechanism within the individual fabric. It is formalised by multiplying the wavefunction with a localising gaussian as in the GRW theory but in a deterministic manner.
Chronobiotics KL001 and KS15 Extend Lifespan and Modify Circadian Rhythms of Drosophila melanogaster
Authors: Solovev Ilya , Shaposhnikov Mikhail , Moskalev Alexey
Published: July 2021

Chronobiotics is a group of drugs utilized to modify circadian rhythms targeting clock-associated molecular mechanisms. The circadian clock is known as a controller of numerous processes standing behind aging. Hypothesis: KL001 and KS15 targeting CRY, affect lifespan, locomotor activity and circadian rhythm of Drosophila melanogaster. We observed a slight (2%, p<0.001) geroprotective effect on median lifespan (5 µM solution of KL001 in 0.1% DMSO) and a 14% increase in maximum lifespan in the same group. KS15 10 µM solution extended males’ median lifespan by 8% (p <0.05). The statistically significant positive effects of KL001 and KS15 on lifespan were not observed in female flies. KL001 5 µM solution improved locomotor activity in young male imagos (p<0.05) and elevated morning activity peak in aged imagos and modified robustness of circadian rhythms, leaving the period intact. KS15 10 µM solution decreased the locomotor activity in constant darkness and minimized the number of rhythmic flies. KL001 5 µM solution improved by 9% the mean starvation resistance in male flies (p<0.01), while median resistance was elevated by 50% (p<0.0001). This phenomenon may suggest the presence of the mechanism associated with improvement of fat body glucose depos’ utilization in starvation conditions which is activated by dCRY binding KL001.
The efficacy of intranasal recombinant interferon alpha-2b for emergency prevention of COVID-19 in healthcare workers
Authors:   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation, Feldblium I.V. , Devyatkov M.Yu. ,   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation, Gendler A.A. ,   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation, Maltseva S.M. ,   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation, Repin T.M. ,   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation, Nikolenko V.N. ,   Academician E.A.Wagner Perm State Medical University, Perm, Russian Federation
Published: July 2021

Healthcare workers are one of the main risk groups for COVID-19 infection and should be provided priority protection. Objective. To examine the development dynamics and epidemic process manifestations of COVID-19 in healthcare workers as well as to assess the efficacy of intranasal human recombinant interferon alpha-2b (Grippferon®) for emergency medicationassisted nonspecific prevention of novel coronavirus infection. Patients and methods. The incidence of COVID-19 in Perm healthcare workers was examined using official statistical data in the epidemic dynamics. The prophylactic efficacy of Grippferon® was assessed in the analytic cohort prospective study, involving 561 healthcare workers of infectious diseases hospital departments. Results. The incidence rate of COVID-19 among healthcare workers in Perm for the examined period from 09.03.2020 to 06.12.2020 was four times higher, than in the general population. Healthcare workers aged 30–59 years were found to be more likely to develop COVID-19. Physicians had the highest risk of infection compared to other medical professionals. The prophylactic efficacy of Grippferon® was shown to be high in physicians and nurses, who were in contact with COVID-19 patients. Conclusion. Recombinant interferon alpha-2b-based medication Grippferon® can be recommended for emergency prevention of novel coronavirus infection to ensure epidemiological safety of healthcare workers and patients during the COVID-19 pandemic. Key words: COVID-19, incidence rate, healthcare workers, recombinant interferon alpha-2b, Grippferon, intranasal use, prevention
Penerapan Model Dynamic Conditional Correlation GARCH Pada Data Saham
Authors: Fitriana Ika , Herdiani Erna Tri , Tinungki Georgina Maria
Published: July 2021

Stock is one of the popular financial market instruments. Issuing shares are one of the company's choices when deciding to fund a company. The uncertainty of stock prices in the stock market is an important event to be taken into consideration in making a decision by investors so that a model is needed to describe a stock event. GARCH Dynamic Conditional Correlation (DCC) is a model with a conditional and variance time-dependent that describes the dynamics of stock volatility. This study discusses the DCC GARCH model equation which is applied to the LQ 45 data. The model obtained for BCA shares 𝑸t = +  +  so it can be concluded that DCC GARCH is more appropriate for BCA shares.
Perancangan Aplikasi Peramalan untuk Metode Exponential Smoothing Menggunakan Aplikasi Lazarus (Studi Kasus: Data Konsumsi Listrik Kota Samarinda)
Authors: Septiyanor Hairi , Syaripuddin Syaripuddin , Goejantoro Rito
Published: July 2021

Exponential smoothing is forecasting method used to predict the future. Lazarus is an open source software based on free pascal compiler. at this research, program Lazarus be design used exponential smoothing method to predict electricity consumption data in Samarinda City from September to November 2018. Purposed of this researched is to determine the procedure of building an exponential smoothing forecasting application and obtained forecasting result using the built application. Procedure of built the application are designed interface, designed properties and filled coding. The optimum smoothing parameters were obtained used the golden section method. Based on the analysis, electricity consumption data in Samarinda City shows a trend pattern, then the forecasting was used double exponential smoohting (DES) method are DES Brown and DES Holt. The best forecasting method for at this researched is DES Holt, because DES Holt method produced MAPE 0,0659% less than DES Brown method produced MAPE 0,0843%.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 17.07.2021 г. по 23.07.2021 г.
Authors: Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Зимирова Анастасия , Чумачкова Елена , Сафронов Валентин , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: July 2021

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 17.07.2021 г. по 23.07.2021 г.
Transfer of the Posterior Tibial Tendon for Chronic Peroneal Nerve Palsy
Authors: Wakefield Connor J. , Hamid Kamran S. , Lee Simon , Lin Johnny , Holmes George B. , Bohl Daniel D.
Published: July 2021

» The common peroneal nerve (CPN) is one of the most frequently injured nerves of the lower extremity.

» One-third of patients who develop CPN palsy proceed to chronic impairment without signs of recovery.

» Ankle-foot orthoses can provide improvement with respect to gait dysfunction and are useful as a nonsurgical treatment option.

» Severe cases of CPN palsy demonstrating no signs of recovery may require operative intervention with tendon transfer.
Effect of the Quasi Rate of Loading in Particle Crushing and Engineering Properties of Black Tough Sand
Authors: hattamleh Omar Al , Sharo’ Abdulla , Shanab Laith Abu , Aldeeky Hussein , Dwairi Reyad Al
Published: July 2021

The authors have requested that this preprint be removed from Research Square.
Noncontact Surface Roughness Evaluation of Milling Surface Using CNN-Deep Learning Models
Authors: Bhandari Binayak , Park Gijun
Published: July 2021

This paper presents the analysis of end milled machined surfaces backed with experimental and deep learning model investigations. The effect of process parameters like spindle speed, feed rate, depth of cut, cutting speed, and machining duration were investigated to find machined surface roughness using Taguchi orthogonal array. The experiments were conducted on Aluminum A3003, a common material widely used in industries. Following standard DOE using Taguchi orthogonal array, surface roughness was recorded for each machining experiment. Surface roughnesses for the current study were categorized into four classes viz., fine, smooth, rough, and coarse based on the roughness value Ra. Images of the machined surface were used to develop CNN models for surface roughness class prediction. The prediction accuracies of the CNN models were compared for five types of optimizers. It was found that RAdam optimizer performed better among others with the training and test accuracy of 96.30% and 92.91% respectively. The accuracy of the prediction is higher than 90% thus has the potential to substitute human quality control procedures, saving time, energy, and cost. Conversely, the developed CNN model can assist in acquiring preferred machining conditions in advance. Finally, it can eliminate the dependency on expensive surface roughness measuring devices and have enormous practical applications in quality control processes.
Clinicopathological Characteristics and Outcomes of 23 Patients with Secretory Carcinoma of Major Salivary Glands
Authors: Sun Jingjing , Liu Sirui , Fu Kun , Gao Ning , Li Rui , He Wei , Gao Zhenjie
Published: July 2021

This retrospective study investigated the clinicopathological characteristics of secretory carcinoma of salivary glands (SCSG) in 23 patients with histopathologically confirmed SCSG between January 2010 and December 2020. In total, 13 males and 10 females were enrolled (ratio, 1.3:1) from 10 to 69 years of age (median 45 y); the average disease duration was 2.44 y (0.25–20 y). Twenty-one patients (91.3%) had SCSG in the parotid gland, and two (8.7%) in the submandibular gland. All patients had single nodules with diameters of 0.8–4.8 cm (average 2.6 cm); five with lymph node metastases, and two with distant metastases. Immunohistochemically, tumors stained positive for S-100, mammaglobin, CK7, and GATA3, and negative for DOG1, P63, and calponin, with Ki-67 positivity from 1–50%. ETV6 gene rearrangement was confirmed in 15 patients. All patients underwent oncological resection, four had radioactive particles implanted postoperatively, one received chemotherapy, and seven underwent chemoradiotherapy. Six patients had regional recurrences, two distant metastases, and one died before the last follow-up. SCSGs are typically indolent, with a low locoregional recurrence rate and excellent survival. Prognosis is correlated to clinical stage, pathological grade, and surgical procedures.
Early Warning Evaluation of Tuberculosis and Meteorological Factors in Shanxi Province based on Dynamic Bayesian Network
Authors: Li Mei-Chen , Zhang Zhuang , Ren Hao , Fan Yue-Ling , Song Wei-Mei , Fan Li-Yu , Quan Di-Chen , Gao Jian-Wei , Chen Li Min , Qiu Li Xia
Published: July 2021

Tuberculosis is a major global public health problem. However, there haven’t been reported the study of meteorological factors related to the incidence of tuberculosis in Shanxi Province. Therefore, it is very urgent to establish an early warning system that easily operate of tuberculosis. The epidemiological characteristics of tuberculosis in Shanxi Province were described, and the Dynamic Bayesian Network early warning model was established by time series cross-correlation analysis and Bayesian Network. The incidence showed an overall downward trend from 2008 to 2017 with certain seasonal characteristics. Based on cross-correlation analysis, it is reasonable to use Dynamic Bayesian model fitting with meteorological factors lagging for 2 months. Comparison of classification and recognition performance of the Dynamic Bayesian Network, Bayesian Network and support vector machine model shows that Dynamic Bayesian Network has the highest classification accuracy in the two regions. In Shanxi Province, tuberculosis cluster in time, space and time and space, and incidence peak is in spring and early summer, seven meteorological factors are the main factors affecting the incidence of tuberculosis. The classification and recognition performance of the Dynamic Bayesian Network early warning model of tuberculosis-meteorological factors is significantly better than the others, and can better predict the future.
Superiority of Adipose-Derived CD34+ Cells Over Adipose-Derived Stem Cells In Promoting Ischamic Tissue Survival
Authors: Liu Yan-Jun , Zhang Tian-Yu , Tan Poh-Ching , Zhang Pei-Qi , Xie Yun , Li Qing-Feng , Zhou Shuang-Bai
Published: July 2021

Background: Tissue ischemia usually leads to necrosis and is a threatening condition associated with reconstructive surgery. Promoting the survival of ischemic tissue is critical for improving clinical outcomes. Although various solutions based on stem cells have been reported, there are still limitations to clinical translation. The aim of this study was to develop an effective method to promote the survival of ischemic tissue.Methods: Adipose-derived CD34+ and CD34- cells were obtained by magnetic bead sorting from the stromal vascular faction (SVF). Adipose-derived stem cells (ADSCs) were collected by subculture. The angiogenic capacities of CD34+ cells, CD34- cells and ADSCs were evaluated in vitro by comparing mRNA and protein expression. Random axial flaps in nude mice were used to evaluate the efficacy of these cells in protecting tissue from necrosis. The effect of these cells in preventing inflammation was also evaluated.Results: Our data suggest that CD34+ cells expressed higher levels of angiogenetic factors and lower levels of inflammatory factors than the other cell types. More vessel branches were formed when human umbilical vein endothelial cells (HUVECs) were treated with conditioned medium from CD34+ cells than conditioned medium from the other cell types. Compared to ADSCs, CD34+ cells showed significantly higher efficacy in promoting tissue survival. More CD31+ cells and higher levels of angiogenic factors were observed in tissues from the CD34+ group than in those from the other groups. Lower levels of the proinflammatory factors TNF-α and IL-1b and higher levels of anti-inflammatory factors were found in the CD34+ group than in the other groups.Conclusion: Adipose-derived CD34+ cells showed better efficacy in improving ischemic tissue survival than ADSCs by reducing tissue inflammation and promoting angiogenesis. CD34+ cells can be obtained easily and may be suitable for clinical applications.
Intraoperative radiotherapy with low energy x-rays after neurosurgical resection of brain metastases – Augsburg University Medical Center experience
Authors: Kahl Klaus-Henning , Balagiannis Nikolaos , Höck Michael , Schill Sabine , Roushan Zoha , Shiban Ehab , Müller Heiko , Grossert Ute , Konietzko Ina , Sommer Björn , Maurer Christoph J. , Berlis Ansgar , Heidecke Volkmar , Janzen Tilman , Stüben Georg
Published: July 2021

Purpose External beam radiotherapy (EBRT) is the predominant method for localized brain radiotherapy (LBRT) after resection of brain metastases (BM). Intraoperative radiotherapy (IORT) with 50kV x-rays is an alternative way to irradiate the resection cavity focally after BM surgery with the option to shorten the overall treatment time and limit normal tissue irradiation.Methods We retrospectively analyzed the outcomes of all patients who underwent neurosurgical resection of BM and 50kV x-ray IORT between 2013 and 2020 at Augsburg University Medical Center.Results We identified 40 patients with 44 resected BM treated with 50kV x-ray IORT. Median diameter of the resected metastases was 2.8 cm (range 1.5–5.9 cm). Median applied dose was 20 Gy. All patients received standardized follow-up (FU) including 3-monthly MRI of the brain. Mean FU was 14.4 months, with a median MRI FU for patients alive of 12.2 months. Median overall survival (OS) of all treated patients was 26.4 months (estimated 1-year OS 61.6%). The observed local control (LC) rate of the resection cavity was 88.6% (estimated 1-year LC 84.3%). Distant brain control (DC) was 47.5% (estimated 1-year DC 33.5%). Only 25% of all patients needed WBI in the further course of disease. The observed radionecrosis rate was 2.5%.Conclusion IORT with 50kV x-rays is a safe and appealing way to apply LBRT after neurosurgical resection of BM with low toxicity and excellent LC. Close MRI FU is paramount to detect distant brain failure (DBF) early.
Effects of chelates (EDTA, EDDS, NTA) on Phytoavailability of HMs (As, Cd, Cu, Pb, Zn) using Ryegrass (Lolium multiflorum)
Authors: Nguyen Ngoc Son Hai , Sanderson Peter , Qi Fangjie , Du Jianhua , Nguyen Ngoc Nong , Bolan Nanthi , Naidu Ravi
Published: July 2021

This paper summarises a study of the application of the synthetic chelate ethylenediaminetetraacetic acid (EDTA), and the natural chelates ethylenediamine-N,N-disuccinic acid (EDDS) and nitrilotriacetate (NTA) to enhance ryegrass uptake of the heavy metal(oid)s (HMs) (As, Cd, Cu, Pb and Zn) from contaminated soils in mining sites. The study compares the effects of these chelates (EDTA, EDDS and NTA) on the phytoavailability of HMs (As, Cd, Cu, Pb, Zn) using ryegrass (Lolium multiflorum) through the single addition and sequential addition methods. The results show that application of EDTA, EDDS and NTA significantly increases ryegrass’s (Lolium multiflorum) shoot uptake of some HMs when compared with no EDTA, EDDS or NTA application, particularly through sequential chelate treatment (EDTA 0.5:1 + 0.5:1; NTA 0.5:1 + 0.5:1; EDDS 0.5:1 + 0.5:1). EDTA 0.5:1 + 0.5:1 was more effective at increasing the concentration of Pb in shoots than were the other chelates (EDDS and NTA) and controls. Moreover, the concentrations of Zn in the shoots of ryegrass in LH significantly increased with the application of split dose (0.5:1 + 0.5:1). The plants displayed symptoms of toxicity including yellow and necrotic leaves at the end of the experiment. The selected chelates (EDTA, EDDS and NTA) led to a significant decrease in plant biomass (yield) 28 days after transfer with a maximum decrease in EDTA treatment (0.5:1 + 0.5:1) soils. This decrease was 3.43-fold in HT, 3-fold in LH and 1.59-fold, respectively, relative to the control. HM concentration and dissolved organic carbon (DOC) in pore water, provided an explanation for why fresh weight was significantly reduced with application of chelates in sequential dose (EDTA 0.5:1 + 0.5:1 and NTA 0.5:1 + 0.5:1).
Molecular Dynamics Simulation of siRNA Encapsulated in Carbon Nanotube
Authors: Vaezi Mehran , Movahedpour Ahmad , Taheri-Anganeh Mortaza , Ameri Mehrdad
Published: July 2021

We investigated the encapsulation of small interfering RNA (siRNA) in carbon nanotube (CNT) using molecular dynamics simulation. siRNAs can be used to silence specific genes effectively if they remain intact while they are delivered to their target cells. Along with the various drug delivery systems designed for this purpose, CNTs are a promising one. Based on their shape, siRNA can encapsulate inside CNTs and protect them from degradation. However, several factors can affect siRNA encapsulation inside CNTs including temperature and CNT diameter. Herein, we conducted a simulation study to evaluate the impact of these factors in the placement of siRNA. Our results can be considered in designing further experimental siRNA delivery systems using carbon nanotubes.
Laguncularia Racemosa Leaves from a Mangrove of the Southeast Atlantic Coast, Brazil: Epicuticular Wax, Morphoanatomical Traits and Minerals
Authors: Victório Cristiane Pimentel , Santos Mayara Silva dos , Dias Aimêe Cordeiro , Bento João Pedro Silvério Pena , Souza Marcelo da Costa , Simas Naomi Kato , Arruda Rosani do Carmo de Oliveira
Published: July 2021

Leaves of Laguncularia racemosa (L.) Gaertn. f. were collected from the following mangroves along Brazil’s southeastern Atlantic coast: Coroa Grande (CG), Pedra de Guaratiba (PG) and Marambaia (M). This work aimed to evaluate the presence of minerals by Energy Dispersive X-Ray Spectroscopy (EDS) and Inductively coupled plasma - optical emission spectrometry (ICP-OES); the chemical composition of epicuticular waxes by gas chromatography–mass spectrometry (GC-MS) and the leaf morphoanatomical features. Results revealed variation in metal contents among mangroves in the following ranges: Al (0.307–0.73), Cd (0.004–0.016) and Pb (0.095–0.325) mg/mL by ICP-OES. Leaf epicuticular wax contained more than 50% of triterpenes, in particular the pentacyclic triterpenes lupeol (41.61–55.63%) and β-amyrin (8.81–16.35%), as well as n-alkanes, such as hentriacontane and tetratetracontane. In particular, we observed differences in the micromorphology of the epicuticular wax in the leaves of plants from each of the three evaluated sites, especially around stomatal entrances. Histochemical reaction indicated the presence of zinc in fiber cell walls and druse crystals of leaves.