bluuebunny/crossref_metadata_2025 huggingface dataset:
Immersive reality and Artificial Intelligence: Transforming online learning through intelligent tutoring systems: A theoretical and methodological framework
Authors: Salma EL BOUJNANI  , Majd EL MERAOUI  , Mohamed KHALDI
Published: December 2024

Advances in immersive reality and artificial intelligence (AI) have opened new opportunities to transform online education. This article explores the integration of intelligent tutoring systems (ITS) and immersive technologies, particularly virtual reality (VR) and augmented reality (AR), in learning environments. The theoretical framework draws on concepts such as constructivism, cognitive load management, and collaborative learning to analyze the interactions between these technologies and their impacts on engagement and the personalization of educational pathways. A conceptual methodology based on Design-Based Research (DBR) is proposed, accompanied by a hypothetical scenario illustrating the use of VR and ITS in professional training. The article highlights the benefits, including improved practical skills and knowledge retention, while addressing challenges such as costs, technical complexity, and ethical issues. Finally, perspectives for future research and recommendations for equitable and sustainable adoption are discussed.
Designing and developing a training system based on the STEM approach; case of physical science teaching: research methodology
Authors: Majd El Meraoui  , Ouafae Ninis  , Asmaa Abdoune  , Salma El Boujnani  , Mohamed Erradi  , Mohamed Khaldi
Published: December 2024

This article explores the design and evaluation of a pedagogical device based on the STEM (Science, Technology, Engineering, Mathematics) approach to renovate the teaching of physical sciences. Using a mixed methodology (quantitative and qualitative), the research is studying the impact of this system on teachers' teaching practices, as well as on learners' learning and motivation. The expected results include a significant improvement in the understanding of physics concepts, the development of cross-curricular skills (creativity, critical thinking, communication, collaboration, problem solving), and an increase in learner motivation and engagement. The study also highlights changes in teaching practices, enhanced by the use of technology and active teaching methods. The STEM approach is a promising strategy for transforming science teaching, promoting practical and interdisciplinary learning adapted to the challenges of the XXIᵉ century.
Microneedles: An efficient technique to enhance Transdermal Drug Delivery System
Authors: Gaurav P. Aswar  , Pooja R. Hatwar  , Ravindra L. Bakal  , Vaishnavi S. Kalamb  , Ishar K. Thak
Published: December 2024

Microneedle technology has emerged as a promising tool for enhancing transdermal drug delivery. This technology involves the use of micron-sized needles to create microchannels in the skin, allowing for the delivery of drugs, vaccines, and other therapeutic agents. The skin's outermost layer, the stratum corneum, is the primary barrier to drug penetration, and microneedles have been shown to effectively bypass this barrier. Various types of microneedles have been developed, including solid, coated, dissolving, and hollow microneedles, each with its own advantages and disadvantages. Microneedles have been used to deliver a range of therapeutic agents, including insulin, vaccines, and cancer therapies. The technology has several benefits, including painless and minimally invasive delivery, improved drug penetration, and reduced side effects. Microneedles have also been shown to enhance the delivery of oligonucleotides, vaccines, and other biological agents. Overall, microneedle technology has the potential to revolutionize the field of transdermal drug delivery, offering new hope for the treatment of various diseases and disorders.
Biosynthesis of silver nanoparticles from Inocutis tamaricis and its antimicrobial and antibiofilm activity
Authors: Sara Qahtan Sulaiman  , Shadman Tariq Sadiq  , Mohammed Sami Farhan
Published: December 2024

The target of this work was to synthesis of nanoparticle from mushroom Inocutis tamaricis by green method and assesse of its antimicrobial and antibiofilm against both bacteria and fungi.
Although I.tamaricis widespread in Iraqi farms, however there is no more study about applications in medical and artificial fields, on the other hand global threats of biofilm induce and drive us to find a sustainable rectify, for these reasons we worked on this macro-fungi extract as a sustainable source for green antimicrobial.
The result of nanoparticle characterizations by different techniques UV-Visible spectrophotometer, FTIR,AFM, XRD and SEM Granted us excellence data that reflect positive harvest of nanoparticle solution to be applied on microbial resistance.
After characterization bioactivity was investigated, the findings showed high antimicrobial activity on the level of microbial cells removing from any environment with high removing efficiency reached about 100% microbes removing. results of ant biofilm showed also hi potential for action against biofilm formation reached more than 76 %.
As a general appraise, current nanoparticle consider ideal antimicrobial and antibiofilm agent beside their antitumor and immunomodulating properties serves in future for different medical and artificial fields as large-scale production especially in antimicrobial resistance era.
Evaluation of thermal comfort in residential buildings: A Case Study of Wari, Dhaka
Authors: Farhana Ahmed  , Sarder Mohammad Hafijur Rahman
Published: December 2024

In Dhaka City's tropical climate, achieving thermal comfort in residential buildings remains a critical challenge due to poor architectural designs, inadequate ventilation, and over-reliance on mechanical systems. This study highlights the thermal discomfort experienced by residents in collective housing in the Wari area, where ineffective thermal insulation and ventilation strategies exacerbate indoor temperature extremes, impacting health and increasing energy consumption. The aim of this research is to evaluate the thermal conditions in residential buildings, identify architectural factors influencing thermal comfort, and recommend adaptive solutions to enhance indoor environmental quality. Using an experimental-descriptive method, data was collected through surveys with 67 residents and in-situ measurements in 11 buildings during winter and summer periods. A Rotronic Temperature Data Logger was used to record indoor temperature and humidity at various times of the day. The findings revealed that 96% of residents were dissatisfied with indoor thermal conditions, with 82% reporting significant discomfort during summer. Energy consumption was high, with 81% of participants relying heavily on cooling and heating systems. Poor thermal performance of construction materials and limited ventilation were major contributors to discomfort. Additionally, over one-third of residents reported chronic health issues linked to thermal extremes. The study concludes that architectural solutions such as optimizing window design, enhancing natural ventilation, incorporating shading devices, and improving insulation are critical for mitigating thermal discomfort. These interventions can reduce energy reliance, improve indoor environmental quality, and promote residents' well-being. The findings emphasize the urgent need for sustainable and cost-effective design strategies in Dhaka's housing sector to ensure healthier living environments.
The effect of domestic waste accumulation on the prevalence of rabies in kirkuk city the period 2023
Authors: Shajaan Ridha Hasan  , Zhazan Najat Jabbar  , Feedan Mohammed Junaid
Published: December 2024

Dog bites are a public health problem, especially in low and middle-income countries, including Iraq, where epidemiological studies on dog bites and rabies have been widespread in recent times due to waste accumulation and the large number of stray dogs. A descriptive cross-sectional study used a time, person and place epidemiological model. The highest incidence rate was in males (72.287%), while the incidence rate in females was (25.712%). As for the residential area, Kirkuk City had the highest incidence (52.605%), followed by Al- Hawija district, with an incidence rate of (26.754%). The age group most susceptible to dog bites is 11-20 years, and the age group is 1-10 years, respectively (30.785%) and (22.863%) respectively. The lower extremities were the leading body site exposed to bite injuries, which constituted (48.158%), followed by the upper extremities (43.988%). The months of March, April and May showed the highest percentage of dog bites (14.732%), (13.829%) and (13.759) respectively. It was also found that the highest injuries were recorded within the age group 11-20, which was 443 and a percentage of 30.783%, followed by the age group 1-10, which was 329 and a percentage of 22.863%. The problem of dog bites is considered one of the important health problems in Kirkuk city, which mainly affects males under the age of twenty, as more than four-fifths of the victims did not complete the recommended preventive vaccination against rabies. Developing a strategic preventive health plan to prevent and control this health problem is strongly required.
Changes in causes and outcomes of thoracic trauma cases during the COVID-19 pandemic: Literature review
Authors: Labdagati Apta Pandana  , Yan Efrata Sembiring  , Wiwin Is Effendi  , Dhihintia Jiwangga Suta Winarno
Published: December 2024

Thoracic trauma refers to injuries affecting the chest area, which can lead to damage to the ribs, lungs, heart, and blood vessels. The most common cause of thoracic trauma is motor vehicle accidents. The COVID-19 pandemic has led to the implementation of various policies that have impacted multiple sectors, including healthcare systems and daily habits. Changes in healthcare systems are not limited to infectious cases but also extend to trauma cases. Various challenges have emerged alongside the increasing number of COVID-19 infections, such as shortages of personal protective equipment, ventilators, and hospital beds. The enforcement of pandemic-related policies has also resulted in alterations to daily routines. Lockdowns and social distancing measures have contributed to a decrease in traffic accidents due to reduced public mobility. Additionally, delays in seeking treatment for thoracic trauma due to fears of contracting COVID-19 have led to changes in outcomes. This literature review aims to identify the changes that occurred during the COVID-19 pandemic, particularly concerning the causes and outcomes of thoracic trauma cases.
HPLC estimation of curcumin in different plants of zingiberaceae family
Authors: Rahul Tiwari  , Balkrishna Dubey  , Deepak Kumar Basedia  , Sandra Goutam
Published: December 2024

The comparative analysis of Curcuma zanthorrhiza and Curcuma zedoaria extracts reveals distinct medicinal potentials based on their bioactive compound profiles and curcumin concentrations. Curcuma zedoaria yielded a slightly higher extraction percentage (6.3%) compared to Curcuma zanthorrhiza (5.7%), with both producing dark brown extracts. Qualitative tests indicated that Curcuma zanthorrhiza contains carbohydrates, glycosides, saponins, phenols, flavonoids, and diterpenes, whereas Curcuma zedoaria has alkaloids and proteins, suggesting differing therapeutic properties. Quantitative analysis showed that Curcuma zanthorrhiza has higher total phenol (0.77 mg/100 mg) and flavonoid (0.62 mg/100 mg) contents than Curcuma zedoaria (0.65 mg/100 mg phenols and 0.54 mg/100 mg flavonoids), indicating greater antioxidant potential.
Overall, while both species contain valuable medicinal compounds, Curcuma zanthorrhiza is likely more effective for antioxidant and anti-inflammatory purposes. In contrast, Curcuma zedoaria may provide unique therapeutic benefits due to its alkaloid and protein content. Thus, both species have significant applications in herbal medicine, each serving different medicinal roles based on their distinct bioactive profiles.
Chitosan ‘s role in enhancing nasal drug absorption
Authors: Monisha Basu  , Tranay Verma  , Abhishek Gupt  , Prakash Barle  , Deepanshi sahu  , Bhumika Chandrakar
Published: December 2024

The nasal drug delivery system (NDDS) offers a promising route for the administration of therapeutically active compounds, particularly for those requiring rapid onset of action or bypassing the first-pass metabolism. The system provides a direct pathway to the bloodstream, enhancing bioavailability and enabling effective treatment of both local and systemic conditions. Among various enhancement strategies, chitosan, a biopolymer derived from the exoskeletons of crustaceans, has garnered attention as a potent nasal absorption enhancer. Its mucoadhesive properties and ability to temporarily open tight junctions in the nasal epithelium allow for improved drug permeation, particularly for hydrophilic drugs, peptides, and macromolecules.
This research focuses on the extraction, characterization, and application of chitosan derived from crab and prawn shells to formulate an effective nasal drug delivery system, particularly for the treatment of migraines. The study aims to develop a nasal spray formulation containing sumatriptan Succinate commonly used migraine medication, to enhance its absorption through the nasal mucosa. The role of chitosan in improving the bioavailability and targeting of drugs to the brain is examined, alongside its biocompatibility and safety profile. Through various in-vitro and ex-vivo studies, the pharmacokinetics, pharmacodynamics, and toxicity of the chitosan-based nasal formulation are evaluated. The findings suggest that chitosan enhances the therapeutic potential of nasal drug delivery systems, providing faster relief with improved drug absorption. This study underscores the potential of natural polysaccharides in revolutionizing drug delivery technologies and improving patient outcomes.
Renal collapse: A window into an underlying high-grade hematological malignancy – A case report
Authors: Paras Mahajan  , Suresh Kumar  , Harpreet Singh  , Nidhi Anand  , Abhilash Patowary
Published: December 2024

Kidney disease is prevalent in patients with hematologic malignancies, particularly multiple myeloma (MM) and acute leukemias. These conditions can directly infiltrate the kidneys or disrupt renal function through metabolic and immunological mechanisms. Renal failure is a significant complication, often the second leading cause of mortality in MM patients. Over 50% of multiple myeloma patients experience renal impairment, commonly identified as "myeloma kidney." Occasionally, blastoid morphology of some plasma cells can lead to diagnostic confusion, necessitating the use of immunohistochemistry to distinguish plasma cell leukemia (PCL) from other types of leukemias and lymphomas. Accurate diagnosis of renal disease can also reveal underlying hematologic malignancies, as demonstrated in our case where a kidney biopsy diagnosed a high-grade malignancy, facilitating timely and correct management.
Contraindications of using endolift subdermal lasertherapy technique in the treatment of aesthetic disorders
Authors: Fábio dos Santos Borges  , Amanda Aguiar Sampaio Ferraz  , Giovanna Pontes Pina Vidal  , Margarete Diprat Trevisan  , Hérgia Selma Gregório Nogueira  , Thaine Hazielly  , Nathália Frias de Souza  , Aranilda Alves Nazareth  , Aline Paula Giacomelli  , Julia Fernandes de Almeida  , Mariana Pedroza  , Carlla Vaz  , Tatiane Rafaela de Moura Rodrigues  , Cintia Luciana Alves Santos
Published: December 2024

Introduction: Endolift subdermal laser therapy is a promising technique for reducing fat and treating aesthetic disorders on skin and subcutaneous tissue. However, its application is not riskless, and it is essential to identify contraindications to ensure patient safety during its use.
Objective: This article aimed to describe the contraindications regarding the use of subdermal laser techniques (Endolift and/or Endolaser) used to treat aesthetic disorders.
Methodology: This study is characterized by exploratory research presented through a narrative review, to highlight the need for and importance of rigorous selection of patients initially chosen for treating aesthetic and/or functional dysfunctions with subdermal laser.
Results: The subdermal laser therapy which uses a laser beam of 1470 nm (Endolift) and/or 980 nm (Endolaser), presents important contraindications which must be considered before treatment. Among the main contraindications reported are allergies to anesthetics, blood dyscrasias, vascular disorders, use of anticoagulants, presence of biopolymers in the area to be treated, history of abnormal scarring (such as keloids), in addition to active epidermal lesions and decompensated autoimmune diseases.
Conclusion: Recognizing contraindications of using Endolift is crucial for patient safety and treatment effectiveness and, therefore, careful evaluation of the patient's clinical history and pre-procedure examinations are important and, perhaps, necessary to minimize possible complications associated with the restrictions imposed by such contraindications.
Epigenetic therapies in cancer treatment: Opportunities and challenges
Authors: Oluwaseyi Ajibola Fagbemi  , Damilola Samuel Ojo-omoniyi  , Samuel Imeh Bassey  , Festus Ikechukwu Ogbozor  , Onyeyili Ikemefuna Nnamdi  , Nyerovwo Charity Okei  , Sunday Kaura
Published: December 2024

Epigenetic therapies offer a revolutionary approach to cancer treatment by targeting reversible modifications such as DNA methylation, histone modifications, and non-coding RNAs that regulate gene expression. FDA-approved drugs like DNA methyltransferase inhibitors and histone deacetylase inhibitors have demonstrated clinical efficacy, particularly in hematologic malignancies, while emerging agents like BET and EZH2 inhibitors show promise in addressing therapeutic gaps in solid tumors. This review delves into these advancements, highlighting the integration of epigenetic drugs with immunotherapy, chemotherapy, and targeted therapies to enhance therapeutic precision and overcome resistance. Moreover, it emphasizes opportunities such as biomarker-driven personalization and liquid biopsy technologies for real-time monitoring, alongside innovations like single-cell epigenomics and CRISPR-based tools that facilitate tumor heterogeneity studies and precise therapeutic interventions. Despite these developments, challenges such as off-target effects, delivery inefficiencies, and regulatory hurdles persist, necessitating further innovation. By integrating epigenetic therapies with RNA-based drugs, nanomedicine, personalized vaccines, 3D epigenomics, and artificial intelligence, this review underscores the transformative potential of these therapies in redefining oncology, offering personalized, durable, and precise solutions to the complexities of cancer.
Brain metastasis from endometrial cancer treated by surgery and stereotaxic radiotherapy on the operating bed: A case report and review of the literature
Authors: R. LARAICHI  , K. NOUNI  , S. SMITI  , O. ALLAOUI  , I. SKITIOUI  , T. EDITH  , A. LACHGAR  , H. EL KACEMI  , T. KEBDANI  , K. HASSOUNI
Published: December 2024

The occurrence of brain metastases from endometrial cancer is a rare phenomenon. Despite the poor prognosis of this presentation, offering the patient curative ablative treatment, when possible, improves significantly the prognosis and quality of life.
We report in this work the case of a 61-year-old female patient, treated in 2024 for endometrial cancer initially considered to be endometrioid type classified at stage II according to the FIGO 2023 classification, with a grade 3 and presence of vascular emboli. 8 months after her diagnosis, she developed an isolated brain metastasis, without other secondary distant locations. The revelation of this metastasis made it possible to adjust the initial histological diagnosis of endometrial cancer to carcinosarcoma. Our patient was treated by total surgical excision followed by stereotaxic irradiation of the surgical bed at a dose of 27 GY in 3 fractions, with good clinical tolerance. A summary of previous studies and recommendations on the treatment of brain metastases from endometrial cancer was presented.
Randomized controlled trial of analgesic effect and movement improvement between Meridian Balancing Acupuncture Method and standard Local Acupuncture in the treatment of Cervical Type Cervical Spondylosis
Authors: Massimo Bondi  , Zhiyuan Bian  , Jianqiao Fang
Published: December 2024

Objective: To compare the therapeutic efficacy of analgesic effects and motility improvement between Meridian Balancing Acupuncture Methods (MBAM) and Local Acupuncture in the treatment of Cervical Type Cervical Spondylosis.
Methods: Sixty patients with Cervical Type Cervical Spondylosis were randomly divided into MBAM group and Local Acupuncture group. In MBAM intervention, up to 10 sensitive/reactive distal points on the limbs were selected and manipulated, while patients rotated their necks. In Local Acupuncture intervention 10 sensitive acupoints were selected and manipulated on the neck, upper back, and shoulders. Both groups underwent 30-minute treatments, three times during one week. Visual Analog Scale (VAS) pain levels and Cervical Spine Range of Motion (ROM) in three directions were assessed before and after each treatment, and at follow-up.
Results:
· VAS Scores were significantly reduced within both groups (P<0.05), however after 2nd and 3rd treatments, MBAM VAS scores were significantly lower (P<0.05). MBAM VAS scores differences were, in general, all significantly higher than Local Acupuncture (P<0.05).
· In general within MBAM group, ROM in all three directions significantly increased (P<0.05). Within Local Acupuncture group, ROM improvements were more limited. After the 3rd treatment, MBAM demonstrated significantly higher Rotation ROM (P<0.05). Overall, ROM differences in all three directions were significantly higher in MBAM than in Local Acupuncture (P<0.05).
· Total effective rate was 100% in both groups. However, significant effective rate was statistically higher in MBAM (93.33%) compared to Local Acupuncture (73.33%) (P<0.05).
Conclusion: Both treatments can effectively relieve pain and improve limited motion in Cervical Type Cervical Spondylosis patients. Although Local Acupuncture showed no immediate improvement in several single treatments. MBAM outperformed Local Acupuncture in immediate and short-term analgesic effects, although both treatments were comparable at follow-up. Overall, MBAM demonstrated superiority in improving cervical motility, with immediate, short term and follow-up better outcomes. After the treatment course, MBAM demonstrated superior curative effect compared Local Acupuncture
THE RELATIONSHIP BETWEEN HADITH AND MODERN SCIENTIFIC KNOWLEDGE
Authors: Adnir Farid , Harahap Alwi Padly
Published: December 2024

This study discusses the relationship between hadith and modern scientific knowledge, focusing on the contribution of hadith to medical science. The background of this study is the need to understand and integrate Islamic teachings, especially hadith, with the development of science and technology, especially in the health sector. This study aims to explore and analyze the relevance of hadith in the context of medical practice and how the values ​​contained in hadith can contribute to the advancement of medical science. By using qualitative methods through literature studies and thematic analysis. The study's results indicate that several hadith contain health principles that align with modern scientific findings, such as maintaining cleanliness, a healthy diet, and preventing disease. The discussion outlines how these hadiths not only have historical relevance but can also be the basis for ethics and practice in modern medicine, thus encouraging the creation of integration between spiritual values ​​and scientific approaches in health services. This study is expected to provide new insights into understanding the contribution of hadith to the development of medical science and encourage collaboration between religious and medical scientists.
BASIACUONG: ORAL TRADITION IN KAMPAR MALAY CEREMONIAL PROCESSIONS
Authors: Rahman Rahman , Ilyas Ilyas , Darussamin Zikri , Syafii Achmad Ghozali , Zailani Zailani , Hulawa Djeprin E , Fauzi Ahmad
Published: December 2024

For Muslims, hadith is something very important because it contains various traditions and habits that developed during the time of the Prophet (PBUH). Indonesia is known for its various traditions and cultures in various regions where these traditions and cultures are integrated with the social life of the community. One of them is the oral tradition of Basiacuong found in the Malay community in Kampar Regency which has been applied for generations where previously it had been carried out by Kampar community leaders. This research is a field research, by tracing directly to the field of objects in the field to dig up information and obtain various data that appear in the field, by observing social phenomena that exist in the community when the tradition is carried out. The location of this research is Koto Perencaran Village, Kampar Regency, because the community in the village still maintains the oral tradition of Basiacuong and applies it in various traditional ceremonies such as marriage, circumcision, akikah, inauguration of traditional heads and so on. Data collection techniques include observation, interviews, and documentation. The results of this study conclude that the Basiacuong tradition found in the Malay community in Koto Perambahan Village, Kampar Regency is the implementation and interaction of living hadith, because the tradition contains good messages and advice, even though the tradition is carried out in traditional ceremonies.
Artırılmış Gerçeklik Uygulamalarıyla Desteklenmiş Geometri Öğretiminin Öğrencilerin Başarılarına ve Tutumlarına Etkisi
Authors: Kösa Temel , Kurnaz Yaşar Emine
Published: December 2024

Bu araştırmanın amacı bir artırılmış gerçeklik (AG) uygulaması olan GeoGebra 3D Hesap Makinesi ile yürütülen derslerin 5. sınıf öğrencilerinin başarı ve tutumları üzerindeki etkilerini belirlemektir. Çalışma yarı deneysel yöntemle yürütülmüştür. Araştırmanın örneklemini, Trabzon il merkezinde bulunan bir devlet okulundaki 59 beşinci sınıf öğrencisi oluşturmaktadır. Çalışmanın deney grubunda 30, kontrol grubunda 29 öğrenci bulunmaktadır. Çalışmada veriler; “Geometri Başarı Testi”, “Matematiğe Yönelik Tutum Ölçeği” ve “Artırılmış Gerçeklik Uygulamaları Tutum Ölçeği” kullanılarak toplanmıştır. Verilerin analizinde bağımlı ve bağımsız t-testi ile kovaryans analizi (ANCOVA) kullanılmıştır. Araştırma sonuçları, AG uygulamalarıyla destekli öğretimin yürütüldüğü deney grubu öğrencileri ile özel bir müdahalenin yapılmadığı kontrol grubu öğrencilerinin akademik başarı ve matematik tutumları arasında anlamlı bir fark olduğunu göstermiştir. Yine araştırma sonuçları deney grubunda yürütülen derslerin öğrencilerin AG uygulamalarına yönelik tutumları üzerinde pozitif bir etki oluşturduğunu ortaya koymuştur. AG teknolojisinin soyut olan matematiksel kavramları somutlaştırması ve farklı bir öğrenme ortamında öğrencilere deneyimler yaşatmasının bu sonuçların elde edilmesinde etkili olduğu düşünülmektedir. Araştırma sonuçları dikkate alındığında, AG uygulamalarının farklı sınıf seviyelerinde ve farklı disiplinlerdeki etkilerinin de incelenebileceği önerilmektedir.
Examination of The Aegean Region in Terms of Truffle Potential
Authors: Özderin Sevgin , Allı Hakan
Published: December 2024

Truffles, belong to the Tuber genus of the Tuberaceae family and are the fruit of a mycorrhizal fungi and have been worldwide regarded as ecologically and commercially valuable. Truffle mushroom, known for its culinary value, has a very high nutritional value. Truffles, are a distinct category of hypogeous fungi known for their unique aroma and exceptional nutritional value. Truffles are expensive because they are rare and difficult to grow, making them one of the most expensive foods in the world. The fact that it is difficult to find in nature and is gastronomically valuable has led to the development of culturing methods for truffle mushrooms. Truffles can grow in temperate climates, including regions of Türkiye Italy, France, Spain, Australia and the US. Interest in truffle hunting and trade in Türkiye has been increasing in recent years.
In this study, truffle species were determined in different localities of Aydın, Denizli, Muğla, and Uşak and the truffle potential of these provinces were revealed. Naturally growing in Aegean region, obtained from the field studies constitute the main materials. Photographs of the collected specimens were taken and their ecological and morphological characteristic were recorded. The aim of the study is to determine the naturally growing truffle habitats in the Aegean Region and to highlight the regions with truffle potential.
Efectos adversos a la vacuna Pfizer-BioNTech en personal de un hospital de tercer nivel
Authors: Ramírez Camacho Mario Alberto , Arcos-Díaz Abraham , Torres-Erazo Darwin Stalin , Argáez-Ojeda Kyra Angélica , Marín-Alvarado Patricia del Carmen , Lara-Riegos Julio César
Published: December 2024

Introducción: Una de las vacunas para combatir la pandemia por el coronavirus 2019 (COVID-19), fue la de tipo ARN-mensajero desarrollada por Pfizer-BioNTech. A inicios de 2021 los trabajadores de hospitales en México recibieron dos dosis de esta vacuna. El objetivo de este estudio fue determinar la frecuencia de eventos adversos (EA) a la vacuna de Pfizer-BioNTech en una cohorte de personal de un hospital de tercer nivel en el sureste de México e identificar los factores asociados con el desarrollo de EA.
Método: Estudio transversal, observacional y descriptivo, realizado en personal de un hospital de tercer nivel. Los EA fueron identificados mediante vigilancia activa y seguimiento vía telefónica entre el segundo y quinceavo día posterior a la primera y segunda inmunización. Los datos demográficos y clínicos fueron capturados en una base de datos electrónica.
Resultados: Se encuestaron a 1033 sujetos, con una edad promedio de 39.04±9.20 años y 53.4% mujeres. El 94.5% de los sujetos experimentaron al menos un EA después de administrarles la vacuna Pfizer-BioNTech. Se detectaron un total de 2805 EA (1360 primera dosis y 1445 segunda dosis). Los EA notificados con mayor frecuencia en ambas dosis fueron dolor en la zona de aplicación, cefalea, fatiga y pirexia.
Conclusiones: La frecuencia de los EA en el presente estudio fue consistente con reportes previos para la vacuna Pfizer-BioNTech. Los EA fueron leves y transitorios mostrando buena tolerancia. El sexo femenino, tener algunas enfermedades crónico-degenerativas y antecedentes de alergia se asociaron significativamente con la presencia de algún EA.
Formulation, Development and Evaluation of Herbal Pediatric Edible Jelly for Cough
Authors: Surana Khemchand , Sonawane Vaishali , Yeola Chaitali , Musale Jayesh , Mahajan Sunil , Sonawane Deepak , Sonawane Vijayraj , Keservani Raj
Published: December 2024

Introduction: The children’s resistance to dosage regimens is one of the challenging issues in pediatric therapy. There are two significant issues with pediatric patients: a lack of self-drug administration skills and patient compliance. The medical characteristics of herbs have become increasingly important due to their lack of side effects, low cost, and biocompatibility. 
Method: The herbs that will be used are Ocimum sanctum (Tulsi), Adhatoda vasika (Adulsa), Elettariacardamomum (Cardamom), Zingiberofficinale (Ginger), Mentha piperita (Peppermint), Glycyrrhiza glabra (Liquorice), Eugenia caryophyllus (Clove), Cinnamomum zeylanicum (Cinnamon), and Honey. The formulation were prepared by decoction method and evaluated.
Results: These herbs’ extracts show good antimicrobial activity against E. coli. The formulated jelly shows good appearance, pH, disintegration, and spreadability. We conduct a 6-month stability study on the formulated jelly. It has a good appearance and does not change pH. So, the formulated jelly can be stable for up to 6 months.
Conclusions: The data revealed that the optimized formulation had not shown any change in their appearance or pH. So, the formulated jelly can be stable for up to 6 months. The formulations exhibited excellent antimicrobial activity, which is suitable to administer to children as an alternative oral solid dosage form.
Desde la necesidad de información a la estrategia de búsqueda, pasando por el formato PICO
Authors: Olry de Labry-Lima Antonio , Tortosa-La Osa Silvia , Martin-Ruiz Eva
Published: December 2024

Dado el crecimiento exponencial de la producción científica, resulta imprescindible que profesionales y la comunidad universitaria dispongan de herramientas y competencias para hacer eficiente la búsqueda de información relevante. Las necesidades de información requieren ser trabajadas y transformadas en preguntas susceptibles de ser contestadas, para lo que resulta de gran utilidad la adaptación al formato PICO: acrónimo de Paciente, Intervención, Comparación y Resultados (outcomes en inglés). La utilización de esta fórmula servirá para la identificación de los elementos fundamentales de dicha pregunta, así como guía durante todo el proceso búsqueda de información, ayudando en la definición y construcción de la estrategia de búsqueda. Este trabajo presenta las claves para la formulación de preguntas en formato PICO con el objetivo de avanzar en nuestras búsquedas bibliográficas.
APPLICATION OF PROBING FOR THE EQUIPMENT OF ENGINEERING UNITS OF THE AFU
Authors: Rudin A.A. , Nesevrya P.I.
Published: December 2024

Problem Statement. To assess the mobility of military equipment in various field conditions, special attention is required for the rapid monitoring of soil foundations. One effective method for studying soil properties and structure is static or dynamic probing, which can be performed using a portable device such as a penetrometer. A key advantage of the probing method is its ability to determine the location of soil layers in field conditions and to evaluate soil homogeneity, which indirectly reflects its main physical and mechanical properties. This method provides an expedient assessment of the soil’s load-bearing capacity, not only in terms of heavy equipment passability but also to estimate the conditions and labor requirements for constructing fortifications, which depend on the site’s soil conditions. The article focuses on the use of both portable handheld penetrometers and hydraulic-driven options that are used to equip special engineering vehicles in the armies of various countries. Additionally, the need for domestic production of such devices and their equipping in the relevant units of the Armed Forces of Ukraine (AFU) for the operational control of soil foundation quality in field conditions has been recognized. Scientific Novelty and Practical Significance. The study identifies the need for penetrometers in specialized engineering vehicles of the Armed Forces of Ukraine, as well as for certain missile systems. Conclusions. Based on the research analysis, it is concluded that there is significant potential and necessity for applying soil probing methods within the engineering units of the Ukrainian Armed Forces. Furthermore, the development, production, and deployment of portable penetrometers for military equipment would enable rapid analysis of soil conditions in field environments.
SEARCH FOR A MODEL OF OFFICE WORKFLOW OPTIMISATION FOR INSTITUTIONS, ORGANISATIONS AND ENTERPRISES
Authors: Savchenko S.V. , Prokofieva K.A. , Reshetilova O.M.
Published: December 2024

The relevance of effective record-keeping in administrative systems is growing due to the increasing role of information in today's society. Traditionally regarded as a technical function, document management now demands intellectual oversight within organizations and in communication between institutions. Current challenges include the need for transparency, legal compliance, preservation of institutional memory, improved governance, and data security. An ideal system encompasses regulatory standards, accountability, and the inclusion of both paper and digital formats. Efficient records management also requires clear definitions of roles and responsibilities, combining paper and electronic workflows effectively. Automation, staff training, and process optimization are key factors for success. Problems within current systems include the limited application of state regulations to private organizations and a lack of research supporting the use of modern technology. Additionally, standardization should not be absolute, as it must balance operational efficiency with adaptability. Centralized operations, pre-screening of documents, and clear communication are essential for creating streamlined workflows. Ensuring economic benefits through optimized document management is crucial, particularly in commercial enterprises. These systems enhance productivity, reduce operational costs, and facilitate rapid decision-making. Moreover, automated solutions help prevent errors, safeguard compliance, and protect sensitive information. By integrating modern technologies and continuous process improvements, businesses can adapt to evolving market conditions. Ultimately, effective document management serves as a strategic tool, ensuring systematization, control, and improved efficiency across all types of organizations.
LEGISLATIVE REGULATION OF ENVIRONMENTAL PROBLEMS IN THE RADIOACTIVE-CONTAMINATED TERRITORY OF THE FORMER URANIUM PRODUCTION
Authors: Bielikov A.S. , Kaplia O.I. , Kaplia I.O. , Pylypenko O.V.
Published: December 2024

Problem statement. In connection with the conduct of hostilities in the territory of the Dnipropetrovsk region and in other territories of Ukraine, the enterprises of the nuclear fuel complex are constantly faced with environmental dangers that can bring shelling and bombing. Along with this, there is the possibility of carrying out terrorist acts at radiation-hazardous facilities or at energy facilities of Ukraine. In connection with the fact that the industrial sites of the former uranium production of the “PCH” industrial complex are located quite close to the line of combat, this leads to an increase in the dangers and risks of an environmental accident with the release of radioactive substances. The purpose of the article is to analyze the existing regulatory and legal acts that ensure stable regulatory, organizational and technological functioning of such radiation-hazardous facilities as industrial sites and separate tailings storage facilities (sludge impoundments) using the example of the former uranium production of the "PCH" industrial complex. Determine the possibility of regulatory and legal application of express methods of registration of radiation pollution by the method of remote data collection and mathematical modeling in radiation-contaminated territories, if there is a man-made or military emergency. Conclusion. During the analysis of threats to radiation-hazardous objects located in the Dnipropetrovsk region, it was determined that the main threat is man-made industrial or military accidents at RНO with the release of radioactive substances into the atmosphere, lithosphere and hydrosphere. Since the beginning of the full-scale war of the Russian Federation against Ukraine, the enemy has captured two nuclear plants: the Chornobyl nuclear power plant in the Kyiv region and the Zaporizhia nuclear power plant in the Zaporizhia region. That is why it is necessary to determine what actions need to be taken in order to fulfill the requirements of regulatory and legal documents and acts of the state in the conditions of constant threats and dangers in the conditions of military aggression. In accordance with the actions, it is also necessary to determine and calculate the environmental consequences of a possible man-made accident or military shelling in the conditions of an operating enterprise that performs security, physical protection and radiation monitoring of the RНO.
ANALYSIS OF MASS TRANSFER PROCESSES BASED ON NUMERICAL MODELS
Authors: Biliaiev M.M. , Tymoshenko O.A. , Kalashnykov A.V. , Kovalenko A.S. , Chirkov A.O.
Published: December 2024

Problem statement. Aeration tanks and settling tanks are most commonly used in wastewater treatment processes. An important problem is the development of effective specialized mathematical models for analyzing the efficiency of these wastewater treatment facilities. The purpose of the article. Development of numerical models for calculating mass transfer processes in biological reactors and settling tanks of wastewater systems. Methodology. To describe the processes of mechanical and biological wastewater treatment, fundamental equations of continuum mechanics are used. To model the process of activated sludge, oxygen and substrate transport in a biological reactor, three-dimensional mass transfer equations are used. To describe the movement of a pollutant in a settling tank, a 3D equation of convective-diffusion transport of a significant conservative impurity is used. Hydrodynamics in treatment plants is described by the spatial Laplace equation for the velocity potential. Finite-difference schemes are used for numerical integration of the modeling equations. Scientific novelty. The article considers numerical models for determining the concentration of oxygen, activated sludge, substrate in a bioreactor. Numerical models are proposed for analyzing the efficiency of the wastewater treatment process in settling tanks. Numerical models are built for determining the field of wastewater flow velocity in bioreactors and settling tanks. The proposed mathematical models can be used to assess the efficiency of structures that carry out mechanical and biological wastewater treatment. Practical significance. Numerical models for determining the velocity field in aeration tanks and settling tanks, as well as numerical models for solving problems of assessing the efficiency of wastewater treatment in these structures, are proposed. The developed numerical models allow for quick, on-line, solution of applied problems. Conclusions. The developed numerical model has been implemented in software. The results of the computational experiment are presented.
INVESTIGATION OF THE PATTERNS OF STRUCTURE FORMATION AND MECHANICAL PROPERTIES OF STEELS DURING HEAT TREATMENT
Authors: Gul Yu.P. , Sobolenko M.A.
Published: December 2024

The relevance of the work. The use of economically alloyed boron-containing steels significantly expands the production volumes of high-strength products obtained by cold bulk stamping methods. Existing methods for preparing metal for cold plastic deformation include the operation of spheroidizing annealing, which is characterized by high energy and time expenditures. Additionally, traditional methods of preparing low-carbon steels for cold deformation have several drawbacks: high consumption of electricity and gas during annealing in furnaces, low productivity, difficulty in ensuring uniform heating and cooling of metal blanks, and environmental pollution. A promising direction is the electrothermal treatment of steel blanks, distinguished by high metal heating rates. To develop high-speed spheroidizing annealing regimes for low-carbon steels, it is necessary to understand the laws governing the formation of structure and properties during heating and cooling. Purpose. To investigate critical points and identify the peculiarities of the influence of cooling rates of undeformed austenite on the volumetric fraction of structural components of 20Mn2B steel. Methodology. In studying the regularities of structure formation, the differential thermal method was used, followed by the investigation of the microstructure and hardness of steel samples. The results. A quantitative and qualitative picture of structure formation during heating and cooling of boron-containing steels was obtained. The possibility of developing high-speed spheroidizing annealing regimes for low-carbon steels with the achievement of a uniform distribution of cementite globules in the ferritic matrix was experimentally confirmed. Conducted research and analysis of the obtained data allowed for graphical analysis of the structure formation of the studied steels of the specified chemical composition and to obtain the quantitative content of structural components during cooling at different speeds of undeformed austenite of the steel. The results of experimental studies of structure formation can be used to develop various regimes of thermal treatment with separate heating of boron-containing steels.
Time dependence of a quasi-monochromatic signal in the area of destructive two-beam interference of electromagnetic waves
Authors:   Samara State Technical University  443100, Russia, Samara, Molodogvardeyskaya str., 244, Bukhman N.S.
Published: December 2024

The time dependence of the total signal of two point dipole emitters of electromagnetic waves emitting the same quasi-monochromatic signals (two-beam interference) is considered. It is shown that the time dependence of the envelope of the total signal is close to the time dependence of the envelope of the signal of one emitter with an accuracy of up to a certain delay time. This delay time varies from the usual (geometric) delay time in the light bands of the interference field (the area of constructive interference) to a halved one compared to the geometric one in the dark bands (the area of destructive interference). At the intermediate points of the interference field, the delay time turns out to be complex, that is, the signal is not only shifted in time, but also distorted.
Современные направления поиска лекарственных средств в отношении Klebsiella pneumoniae (обзор)
Authors: Степкина Надежда Николаевна , Великородов Анатолий Валериевич , Самотруева Марина Александровна , Котова Валентина Юрьевна
Published: December 2024

Появление и распространение резистентных штаммов Klebsiella pneumoniae приводит к снижению эффективности антибиотиков, применяемых в настоящее время в терапевтической практике. Поиск новых лекарственных средств в отношении этого опасного патогена ведется в нескольких направлениях, включающих целенаправленный синтез новых веществ с антиклебсиллезной активностью, поиск новых мишеней для действия потенциальных антибиотиков, в том числе на основе метаболического моделирования в масштабе генома K. pneumoniae, скрининга устойчивости к антибиотикам, идентификации потенциальных факторов вирулентности и ряда других подходов. В настоящем обзоре анализируются и обобщаются данные литературы за последние 10 лет по синтезу и изучению потенциальных лекарственных средств в отношении K. pneumoniae с использованием как эмпирического подхода, так и молекулярного докинга.
Цитотоксическая активность ацетоновых экстрактов, полученных из органов растения и клеточных культур Podophyllum peltatum L., в отношении нормальных и опухолевых клеток
Authors: Китаева М. П. , Федотчева Татьяна Александровна , Шимановский Н. Л.
Published: December 2024

С помощью резазурин-теста было показано, что ацетоновые экстракты из органов Podophyllum peltatum L. снижают жизнеспособность фибробластов крысы на 33 – 39 %, экстракты каллусных культур этого растения — на 35 – 50 %, экстракты 14-суточной суспензионной культуры при максимальной концентрации — на 22 %. Обнаружено, что цитотоксическая активность изученных экстрактов в отношении нормальных клеток (фибробластов крысы) ниже на 23 %, чем в отношении опухолевых клеток HeLa, что обосновывает перспективность данных экстрактов как лекарственного растительного сырья для получения препаратов с противоопухолевым действием.