bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-world evidence and clinical observations of the treatment of advanced non-small cell lung cancer with PD-1/PD-L1 inhibitors
Authors: Song Peng , Zhang Jingcheng , Shang Congcong , Zhang Li
Published: March 2019

To summarize the therapeutic effects of PD-1/PD-L1 inhibitors on patients with advanced non-small cell lung cancer (NSCLC) in a real-world setting, we attempted to identify potential molecular biomarkers or clinical factors that reflected the therapeutic effect. The medical records of patients with non-small cell lung cancer who were treated with PD-1/PD-L1 inhibitors were obtained from the outpatient department or inpatient department of Peking Union Medical College Hospital from August 1, 2015, to January 1, 2018. Our follow-up continued until May 1,2018. We chose overall survival (OS) as the primary observation endpoint and progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and safety as the secondary observation endpoints. Efficacy was evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. The Kaplan-Meier method was used to generate survival curves, and we compared the influence of different factors on PFS and OS by the log-rank test. The median follow-up time was 11 months. At the end of the follow-up, 24 patients (61.5%) were still undergoing immunotherapy, and 7 patients (17.9%) had died. Twenty-six cases (66.7%) employed PD-1/PD-L1 inhibitors as first-line treatment, and 7 cases (17.9%) employed PD-1/PD-L1 inhibitors as second-line treatment. Only 6 cases (15.4%) employed PD-1/PD-L1 inhibitors as third-line treatment. Therapeutic effect evaluation: Complete response (CR): 1 case (2.6%). Partial response (PR): 10 cases (25.6%). Stable disease (SD): 16 cases (41.0%). Progressive disease (PD): 12 cases (30.8%). The ORR was 28.2%, and DCR was 69.2%. The median PFS was 25.5 months (95% CI 6.8–44.1 months), which failed to reach the median OS. PD-1/PD-L1 inhibitor treatment is more effective for advanced non-small cell lung cancer patients in a real-world setting than in clinical trials; PD-1/PD-L1 inhibitor treatment is more effective for people who are over 70 than for people who are under 70. Additionally, patients who are over 75 years old have a higher response rate, suggesting that elderly patients may receive more benefits from immunotherapy; Patients who have an epidermal growth factor receptor (EGFR) mutation (+) may benefit from immunotherapy after treatment with a tyrosine kinase inhibitor (TKI). It is essential to identify these potential patients from the entire patient pool; PD-1 may have a certain curative effect on brain metastases from NSCLC. Local radiotherapy may help to improve PD-1 intracranial efficacy.
Survey of allele specific expression in bovine muscle
Authors: Guillocheau Gabriel M. , El Hou Abdelmajid , Meersseman Cédric , Esquerré Diane , Rebours Emmanuelle , Letaief Rabia , Simao Morgane , Hypolite Nicolas , Bourneuf Emmanuelle , Bruneau Nicolas , Vaiman Anne , Vander Jagt Christy J. , Chamberlain Amanda J. , Rocha Dominique
Published: March 2019

Allelic imbalance is a common phenomenon in mammals that plays an important role in gene regulation. An Allele Specific Expression (ASE) approach can be used to detect variants with acis-regulatory effect on gene expression. In cattle, this type of study has only been done once in Holstein. In our study we performed a genome-wide analysis of ASE in 19 Limousine muscle samples. We identified 5,658 ASE SNPs (Single Nucleotide Polymorphisms showing allele specific expression) in 13% of genes with detectable expression in theLongissimus thoracimuscle. Interestingly we found allelic imbalance inAOX1,PALLDandCASTgenes. We also found 2,107 ASE SNPs located within genomic regions associated with meat or carcass traits. In order to identify causativecis-regulatory variants explaining ASE we searched for SNPs altering binding sites of transcription factors or microRNAs. We identified one SNP in the 3’UTR region ofPRNPthat could be a causal regulatory variant modifying binding sites of several miRNAs. We showed that ASE is frequent within our muscle samples. Our data could be used to elucidate the molecular mechanisms underlying gene expression imbalance.
Cytotoxicity of Ag, Au and Ag-Au bimetallic nanoparticles prepared using golden rod (Solidago canadensis) plant extract
Authors: Botha Tarryn L. , Elemike Elias E. , Horn Suranie , Onwudiwe Damian C. , Giesy John P. , Wepener Victor
Published: March 2019

Production and use of metallic nanoparticles have increased dramatically over the past few years and design of nanomaterials has been developed to minimize their toxic potencies. Traditional chemical methods of production are potentially harmful to the environment and greener methods for synthesis are being developed in order to address this. Thus far phytosynthesis have been found to yield nanomaterials of lesser toxicities, compared to materials synthesized by use of chemical methods. In this study nanoparticles were synthesized from an extract of leaves of golden rod (Solidago canadensis). Silver (Ag), gold (Au) and Ag-Au bimetallic nanoparticles (BNPs), synthesized by use of this “green” method, were evaluated for cytotoxic potency. Cytotoxicity of nanomaterials to H4IIE-luc (rat hepatoma) cells and HuTu-80 (human intestinal) cells were determined by use of the xCELLigence real time cell analyzer. Greatest concentrations (50 µg/mL) of Ag and Ag-Au bimetallic were toxic to both H4IIE-luc and HuTu-80 cells but Au nanoparticles were not toxic. BNPs exhibited the greatest toxic potency to these two types of cells and since AuNPs caused no toxicity; the Au functional portion of the bimetallic material could be assisting in uptake of particles across the cell membrane thereby increasing the toxicity.
Staphylococcal Superantigen-like protein 11 mediates neutrophil adhesion and motility arrest, a unique bacterial toxin action
Authors: Chen Chen , Yang Chen , Barbieri Joseph T.
Published: March 2019

Methicillin resistant Staphylococcus aureus (MRSA) is a major human pathogen, which causes superficial to lethal clinical infections. Neutrophils are the most abundant leukocytes in the blood and are the first defense mechanism against S. aureus infections. Here we show Staphylococcal Superantigen-Like protein 11 (SSL11) from MRSA USA300_FPR3757 mediated differentiated human neutrophil-like cells (dHL60) motility arrest by inducing cell adhesion and “locking” cells in adhesion stage, without inducing oxidative burst. Pre-incubation of SSL11 with the glycan Sialyl Lewis X blocked SSL11 function and de-glycosylation of dHL60 cells by PNGase F abolished SSL11 binding, suggesting that SSL11 functions via interacting with glycans. This is the first description of a bacterial toxin inhibiting neutrophil motility by inducing adhesion and “locking” cells in an adhesion stage. Therefore, this study might provide a new target against S. aureus infections.
PTMselect: optimization of protein modifications discovery by mass spectrometry
Authors: Perchey Renaud T. , Tonini Laure , Tosolini Marie , Fournié Jean-Jacques , Lopez Frédéric , Besson Arnaud , Pont Frédéric
Published: March 2019

Discovery of protein modification sites relies on protein digestion by proteases and mass spectrometry (MS) identification of the modified peptides. Depending on proteases used and target protein sequence, this method yields highly variable coverage of modification sites. We introduce PTMselect, a digestion-simulating software which tailors the optimal set of proteases for discovery of global or targeted modification from any single or multiple proteins.
Investigation of natural environmental radioactivity concentration in soil of coastaline area of Ado-Odo/Ota Nigeria and its radiological implications
Authors: Joel E. S. , Maxwell O. , Adewoyin O. O. , Olawole O. C. , Arijaje T. E. , Embong Z. , Saeed M. A.
Published: March 2019

Natural radioactivity in coastaline area soil of Ado-Odo/Ota has been carried out to ascertain the presence of radionuclides using gamma-ray spectroscopy (HPGe detector). The result showed that U-238, Th-232 and K-40 ranged from 24 ± 7–49 ± 10; 67 ± 6–120 ± 9 and 88 ± 17–139 ± 20 Bqkg−1 respectively. The radium equivalent for the samples ranged from 132.51 to 230.91 Bqkg−1 with mean value of 185.89 Bqkg−1. The mean value for the gamma dose rate for the soil samples was estimated to be 81.32 nGyh−1. The estimated values of annual effective dose equivalent ranged from 0.61 to 1.07 mSv y−1. The estimation of alpha index representative (Iα) ranged from 0.12 to 0.24 with mean value of 0.21 while the gamma representative index ranged between 0.465 and 0.810. The activity utilization index of the soil samples ranged from 1.09 to 1.89 with mean value of 1.53. The radiological implication in the study area has shown that the soil samples with gamma dose rate value of 89.99 nGyh−1, 94.39 nGyh−1, 97.40 nGyh−1 and 101.04 nGyh−1 respectively are higher than the recommended value of 80 nGyh−1 and may pose health implication for long term exposure.
A comparison between the abdominal and femoral adipose tissue proteome of overweight and obese women
Authors: Vogel M. A. A. , Wang P. , Bouwman F. G. , Hoebers N. , Blaak E. E. , Renes J. , Mariman E. C. , Goossens G. H.
Published: March 2019

Body fat distribution is an important determinant of cardiometabolic health. Lower-body adipose tissue (AT) has protective characteristics as compared to upper-body fat, but the underlying depot-differences remain to be elucidated. Here, we compared the proteome and morphology of abdominal and femoral AT. Paired biopsies from abdominal and femoral subcutaneous AT were taken from eight overweight/obese (BMI ≥ 28 kg/m2) women with impaired glucose metabolism after an overnight fast. Proteins were isolated and quantified using liquid chromatography-mass spectrometry, and protein expression in abdominal and femoral subcutaneous AT was compared. Moreover, correlations between fat cell size and the proteome of both AT depots were determined. In total, 651 proteins were identified, of which 22 proteins tended to be differentially expressed between abdominal and femoral AT after removal of blood protein signals (p < 0.05). Proteins involved in cell structure organization and energy metabolism were differently expressed between AT depots. Fat cell size, which was higher in femoral AT, was significantly correlated with ADH1B, POSTN and LCP1. These findings suggest that there are only slight differences in protein expression between abdominal and femoral subcutaneous AT. It remains to be determined whether these differences, as well as differences in protein activity, contribute to functional and/or morphological differences between these fat depots.
Characterization of the rumen and fecal microbiome in bloated and non-bloated cattle grazing alfalfa pastures and subjected to bloat prevention strategies
Authors: Azad E. , Derakhshani H. , Forster R. J. , Gruninger R. J. , Acharya S. , McAllister T. A. , Khafipour E.
Published: March 2019

Frothy bloat is an often fatal digestive disorder of cattle grazing alfalfa pastures. The aim of this study was to investigate ruminal and fecal microbiota dynamics associated with development of alfalfa-induced frothy bloat and to further explore how bloat prevention strategies influence the composition of these microbial communities. In a 3 × 3 crossover experiment, twelve rumen-cannulated steers were sequentially subjected to: (1) pure alfalfa pasture, (2) pure alfalfa pasture supplemented with the pluronic detergent ALFASURE, and (3) alfalfa – sainfoin mixed pasture. Eleven out of 12 steers in pure alfalfa pasture developed clinical bloat, whereas ALFASURE treatment prevented the development of bloat in all 12 steers and alfalfa – sainfoin prevented bloat in 5 out of 11 steers. Development of bloat was associated with considerable shifts in the microbiota profile of rumen contents. In particular, the microbiota of solid rumen contents from bloated steers contained higher species richness and diversity. Streptococcus, Succinivibrio and unclassified Myxococcales were enriched in the rumen microbiota of bloated steers, whereas Fibrobacter and Ruminococcus were overrepresented in the rumen contents of non-bloated steers. Our results provide novel insights into bloat-associated shifts in the composition and predicted functional properties of the rumen microbiota of cattle grazing alfalfa pasture.
Deep structural brain lesions associated with consciousness impairment early after hemorrhagic stroke
Authors: Rohaut Benjamin , Doyle Kevin W. , Reynolds Alexandra S. , Igwe Kay , Couch Caroline , Matory Adu , Rizvi Batool , Roh David , Velazquez Angela , Megjhani Murad , Park Soojin , Agarwal Sachin , Mauro Christine M. , Li Gen , Eliseyev Andrey , Perlbarg Vincent , Connolly Sander , Brickman Adam M. , Claassen Jan
Published: March 2019

The purpose of this study was to determine the significance of deep structural lesions for impairment of consciousness following hemorrhagic stroke and recovery at ICU discharge. Our study focused on deep lesions that previously were implicated in studies of disorders of consciousness. We analyzed MRI measures obtained within the first week of the bleed and command following throughout the ICU stay. A machine learning approach was applied to identify MRI findings that best predicted the level consciousness. From 158 intracerebral hemorrhage patients that underwent MRI, one third was unconscious at the time of MRI and half of these patients recovered consciousness by ICU discharge. Deep structural lesions predicted both, impairment and recovery of consciousness, together with established measures of mass effect. Lesions in the midbrain peduncle and pontine tegmentum alongside the caudate nucleus were implicated as critical structures. Unconscious patients predicted to recover consciousness by ICU discharge had better long-term functional outcomes than those predicted to remain unconscious.
Contrasting in vitro and in vivo methanol oxidation activities of lanthanide-dependent alcohol dehydrogenases XoxF1 and ExaF from Methylobacterium extorquens AM1
Authors: Good Nathan M. , Moore Riley S. , Suriano Carly J. , Martinez-Gomez N. Cecilia
Published: March 2019

Lanthanide (Ln) elements are utilized as cofactors for catalysis by XoxF-type methanol dehydrogenases (MDHs). A primary assumption is that XoxF enzymes produce formate from methanol oxidation, which could impact organisms that require formaldehyde for assimilation. We report genetic and phenotypic evidence showing that XoxF1 (MexAM1_1740) from Methylobacterium extorquens AM1 produces formaldehyde, and not formate, during growth with methanol. Enzyme purified with lanthanum or neodymium oxidizes formaldehyde. However, formaldehyde oxidation via 2,6-dichlorophenol-indophenol (DCPIP) reduction is not detected in cell-free extracts from wild-type strain methanol- and lanthanum-grown cultures. Formaldehyde activating enzyme (Fae) is required for Ln methylotrophic growth, demonstrating that XoxF1-mediated production of formaldehyde is essential. Addition of exogenous lanthanum increases growth rate with methanol by 9–12% but does not correlate with changes to methanol consumption or formaldehyde accumulation. Transcriptomics analysis of lanthanum methanol growth shows upregulation of xox1 and downregulation of mxa genes, consistent with the Ln-switch, no differential expression of formaldehyde conversion genes, downregulation of pyrroloquinoline quinone (PQQ) biosynthesis genes, and upregulation of fdh4 formate dehydrogenase (FDH) genes. Additionally, the Ln-dependent ethanol dehydrogenase ExaF reduces methanol sensitivity in the fae mutant strain when lanthanides are present, providing evidence for the capacity of an auxiliary role for ExaF during Ln-dependent methylotrophy.
Carbon replicas reveal double stranded structure of tight junctions in phase-contrast electron microscopy
Authors: Krystofiak Evan S. , Heymann J. Bernard , Kachar Bechara
Published: March 2019

Replica-based freeze-fracture and freeze-etching electron microscopy methods provide surface topography information, particularly suited to studying membrane protein complexes in their native context. The fidelity and resolution of metal replicas is limited by the inherent property of metal atoms to crystallize. To overcome the limitations of metal replicas, we combined amorphous carbon replicas with phase-contrast electron microscopy. Using this approach, tight junction intramembrane fibrils were shown to have a double stranded morphology.
Raspberry-like small multicore gold nanostructures for efficient photothermal conversion in the first and second near-infrared windows
Authors: Plan Sangnier Anouchka , Aufaure Romain , Cheong Soshan , Motte Laurence , Palpant Bruno , Tilley Richard D. , Guenin Erwann , Wilhelm Claire , Lalatonne Yoann
Published: March 2019

Gold nanoraspberries were synthesized by a seed-mediated synthesis with polyethylene glycol-functionalized bisphosphonates.
New insights into the dissociation dynamics of methylated anilines
Authors: Cole-Filipiak Neil C. , Stavros Vasilios G.
Published: March 2019

Combined time-resolved photoelectron spectroscopy and photofragment imaging supports a possible valence-to-Rydberg decay mechanism in methylated anilines.
Mechanisms of phase separation in temperature-responsive acidic aqueous biphasic systems
Authors: Schaeffer Nicolas , Pérez-Sánchez German , Passos Helena , Gomes José R. B. , Papaiconomou Nicolas , Coutinho João A. P.
Published: March 2019

The thermal and acid responsive behaviour of bulky phosphonium-based ILs is elucidated using a mixed experimental and computational approach.
A smartphone fluorescence imaging-based mobile biosensing system integrated with a passive fluidic control cartridge for minimal user intervention and high accuracy
Authors: Lee Won-Il , Park Younghyeon , Park Jaemin , Shrivastava Sajal , Son Young-Min , Choi Hak-Jong , Lee Jaelin , Jeon Byeungwoo , Lee Heon , Lee Nae-Eung
Published: March 2019

A biosensor with minimal user interventions and high accuracy.
Induction of chirality in 4,4′-azopyridine by halogen-bonding interaction with optically active ditopic donors
Authors: Alfuth Jan , Chojnacki Jarosław , Połoński Tadeusz , Olszewska Teresa
Published: March 2019

Co-crystallization of 4,4′-azopyridine with optically active halogen-bonding donors results in induction of chirality in this molecule.
Nitrogen-doped graphene fiber webs for multi-battery energy storage
Authors: Chong Woon Gie , Xiao Fei , Yao Shanshan , Cui Jiang , Sadighi Zoya , Wu Junxiong , Ihsan-Ul-Haq Muhammad , Shao Minhua , Kim Jang-Kyo
Published: March 2019

Freestanding nitrogen-doped graphene fiber webs prepared by wet-spinning for multi-battery charge storage in both LOBs and LSBs.
Structure-pDNA complexation and structure–cytotoxicity relationships of PEGylated, cationic aminoethyl-based polyacrylates with tunable topologies
Authors: Le Bohec Maël , Bonchouo Kenzo Kévin , Piogé Sandie , Mura Simona , Nicolas Julien , Casse Nathalie , Forcher Gwénaël , Fontaine Laurent , Pascual Sagrario
Published: March 2019

The influence of PEGylation and topology on cationic aminoethyl-based polyacrylates has been highlighted on cell viability and pDNA complexation.
CO2-Assisted synthesis of hierarchically porous carbon as a supercapacitor electrode and dye adsorbent
Authors: Zhang Mengnan , Song Yi , Li Wei , Huang Xin , Wang Cheng , Song Tiance , Hou Xiaojian , Luan Sen , Wang Tianqi , Wang Tianyu , Wang Qian
Published: March 2019

A facile and sustainable strategy was developed for the fabrication of hierarchically porous carbons with tunable pore size distributions and architectures.
High-performance cellulose nanofibers, single-walled carbon nanotubes and ionic liquid actuators with a poly(vinylidene fluoride-co-hexafluoropropylene)/ionic liquid gel electrolyte layer
Authors: Terasawa Naohiro , Asaka Kinji
Published: March 2019

This study describes new actuators with cellulose nanofibers, single-walled carbon nanotubes and ionic liquids (CNFs/SWCNTs/ILs) and examines the electrochemical and electromechanical properties of the CNF/SWCNT/IL gel hybrid actuators.
A compatible anode/succinonitrile-based electrolyte interface in all-solid-state Na–CO2 batteries
Authors: Lu Yong , Cai Yichao , Zhang Qiu , Liu Luojia , Niu Zhiqiang , Chen Jun
Published: March 2019

A compatible anode/succinonitrile-based electrolyte interface is achieved owing to the in situ formed NaF-rich interphase through an extremely simple approach.
A bimetallic Au–Ag nanoalloy mounted LDH/RGO nanocomposite: a promising catalyst effective towards a coupled system for the photoredox reactions converting benzyl alcohol to benzaldehyde and nitrobenzene to aniline under visible light
Authors: Sahoo Mitarani , Mansingh Sriram , Parida K. M.
Published: March 2019

The bimetallic surface plasmon chemistry of Au–Ag and the π-carbon skeleton of rGO enhance the exciton concentration and separation over ZnCr-LDH, resulting in notable photocatalytic activity.
Phosphide protected FeS2 anchored oxygen defect oriented CeO2NS based ternary hybrid for electrocatalytic and photocatalytic N2 reduction to NH3
Authors: Sultana S. , Mansingh S. , Parida K. M.
Published: March 2019

A nitrogenase mimicking iron-based ceria heterostructured material with a defect rich surface was fabricated for application in the nitrogen reduction reaction.
Defect-rich MoS2(1−x)Se2x few-layer nanocomposites: a superior anode material for high-performance lithium-ion batteries
Authors: Cai Guohui , Peng Lei , Ye Shiyong , Huang Yucheng , Wang Guangfeng , Zhang Xiaojun
Published: March 2019

The defect-rich, few-layer MoS2(1−x)Se2x endows lithium-ion batteries with better rate performance and cycling stability.
Tuning the dipole moments of nonfullerene acceptors with an asymmetric terminal strategy for highly efficient organic solar cells
Authors: Li Miao , Zhou Yuanyuan , Zhang Jianqi , Song Jinsheng , Bo Zhishan
Published: March 2019

Fused-ring electron acceptors with asymmetric terminals for highly efficient thick-film photovoltaic devices.
A selenamorpholine-based redox-responsive fluorescent probe for targeting lysosome and visualizing exogenous/endogenous hydrogen peroxide in living cells and zebrafish
Authors: Xu Chao , Qian Ying
Published: March 2019

A BODIPY–Se probe could track lysosome and detect lysosomal H2O2 in living cells.
Development of a robust SFC method for evaluation of compatibility for a novel antituberculotic fixed-dose combination
Authors: Petruševska Valentina , Krtalić Iva , Rašić Andrea , Mornar Ana
Published: March 2019

A fast and simple supercritical fluid chromatography method for the simultaneous determination of two antituberculotic drugs, isoniazid and rifabutin, and their impurities from a new proposed fixed-dose combination (FDC) was developed.
Highly active and stable copper catalysts derived from copper silicate double-shell nanofibers with strong metal–support interactions for the RWGS reaction
Authors: Yu Yang , Jin Renxi , Easa Justin , Lu Wei , Yang Man , Liu Xianchun , Xing Yan , Shi Zhan
Published: March 2019

Double-shell hollow nanofiber supported copper catalysts with strong metal–support interactions were prepared and applied in the reverse water–gas shift reaction.
Electrochemical oxidation of trivalent americium using a dipyrazinylpyridine modified ITO electrode
Authors: Lopez Michael J. , Sheridan Matthew V. , McLachlan Jeffrey R. , Grimes Travis S. , Dares Christopher J.
Published: March 2019

We present here the electrochemical oxidation of Am(iii) to AmVO2+ and AmVIO22+ in pH 1 nitric acid using a mesoporous tin-doped indium oxide electrode modified with a covalently attached dipyrazinylpyridine ligand.
Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype
Authors: Rahimi Marwa N. , Foster Henry G. , Farazi Shegufta N. , Chapman Robert , McAlpine Shelli R.
Published: March 2019

LB76is a cyclic peptide that shows great promise as a selective heat shock protein 90 (Hsp90) inhibitor.
Unsaturated vicinal frustrated phosphane/borane Lewis pairs as ligands in gold(i) chemistry
Authors: Ueno Atsushi , Watanabe Kohei , Daniliuc Constantin G. , Kehr Gerald , Erker Gerhard
Published: March 2019

The unsaturated vicinal P/B FLP obtained from the unusual 1,1-hydroboration of dimesitylphosphino(trimethylsilyl)acetylene with Piers’ borane serves as an ambiphilic ligand in gold(i) chemistry.
A free radical alkylation of quinones with olefins
Authors: Liu Shuai , Shen Tong , Luo Zaigang , Liu Zhong-Quan
Published: March 2019

We demonstrated herein an Fe(iii)-mediated radical alkylation of quinones. A wide range of bioactive molecules with quinone motifs can be rapidly synthesized by using readily available and inexpensive NaBH4/NaBD4 with alkenes at room temperature under open flask conditions.
Scalable, room temperature, and water-based synthesis of functionalized zirconium-based metal–organic frameworks for toxic chemical removal
Authors: Chen Zhijie , Wang Xingjie , Noh Hyunho , Ayoub Ghada , Peterson Gregory W. , Buru Cassandra T. , Islamoglu Timur , Farha Omar K.
Published: March 2019

An inexpensive, environmentally benign and scalable strategy was developed to synthesize UiO-66 derivatives in water at room temperature.
The effect of Fe vacancies and Cu adhesion on the magnetic properties of Fe3GeTe2
Authors: Liu Jia , Wang Anping , Pu Kaisong , Zhang Shaozheng , Yang Jianhui , Musho Terence , Chen Liang
Published: March 2019

The magnetic moment of FeI ions decreases significantly due to the presence of the FeII vacancies.
Tuning cavitation and crazing in polymer nanocomposite glasses containing bimodal grafted nanoparticles at the nanoparticle/polymer interface
Authors: Shi Rui , Qian Hu-Jun , Lu Zhong-Yuan
Published: March 2019

The mechanical properties of polymer nanocomposites containing bimodal grafted nanoparticles can be tuned at the nanoparticle/polymer interface using different graft chain types.
Tuning the work function of the silicene/4 × 4 Ag(111) surface
Authors: Taylor Patrick D. , Osborne Dale A. , Tawfik Sherif Abdulkader , Morishita Tetsuya , Spencer Michelle J. S.
Published: March 2019

The work function of the silicene/silver surface can be tuned via functionalisation, according to density-functional theory calculations.
Structural and magnetic studies of KOsO4, a 5d1 quantum magnet oxide
Authors: Injac Sean , Yuen Alexander K. L. , Avdeev Maxim , Orlandi Fabio , Kennedy Brendan J.
Published: March 2019

The quantum magnet KOsO4 has been characterized by a combination of X-ray and neutron diffraction techniques. This represents the first structural and magnetic characterization of a simple Os7+, S = 1/2 oxide system.
What accounts for the color purity of tetradentate Pt complexes? A computational analysis
Authors: Cai Wanlin , Zhang Huize , Yan Xi , Zhao Anchong , He Rongxing , Li Ming , Meng Qingxi , Shen Wei
Published: March 2019

The microscopic mechanism of high color purity was elucidated by computational investigation.
Rydberg state mediated multiphoton ionization of (η7-C7H7)(η5-C5H5)Cr: DFT-supported experimental insights into the molecular and electronic structures of excited sandwich complexes
Authors: Ketkov Sergey Yu. , Tzeng Sheng Yuan , Rychagova Elena A. , Kalakutskaya Lyubov’ V. , Fuss Marco , Braunschweig Holger , Tzeng Wen-Bih
Published: March 2019

The first REMPI/DFT study of a mixed sandwich complex reveals fine ligand effects on structural transformations accompanying electronic excitation.
Molecular design of ionic liquids as novel non-metal catalysts for the acetylene hydrochlorination reaction
Authors: Nian Yao , Zhang Jinli , Li Xiaoyan , Wang Yan , Li Wei , Kolubah Pewee Datoo , Han You
Published: March 2019

This study provides new insights into the design of efficient nonmercuric IL catalysts for the acetylene hydrochlorination reaction.
Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series ofl-phenylalanine-derived surface-active ionic liquids
Authors: Kapitanov Illia V. , Jordan Andrew , Karpichev Yevgen , Spulak Marcel , Perez Lourdes , Kellett Andrew , Kümmerer Klaus , Gathergood Nicholas
Published: March 2019

A comprehensive study devoted to designing green surface-active ionic liquids (SAILs) based on the “benign-of-design” approach results in finding greener alternatives.
Enantiocomplementary decarboxylative hydroxylation combining photocatalysis and whole-cell biocatalysis in a one-pot cascade process
Authors: Xu Jian , Arkin Mamatjan , Peng Yongzhen , Xu Weihua , Yu Huilei , Lin Xianfu , Wu Qi
Published: March 2019

The first demonstration of photochemo-enzymatic whole-cell one-pot enantiocomplementary decarboxylative hydroxylation.
Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system
Authors: Zhang Yi , Guo Hexia , Kim Sung Bong , Wu Yixin , Ostojich Diana , Park Sook Hyeon , Wang Xueju , Weng Zhengyan , Li Rui , Bandodkar Amay J. , Sekine Yurina , Choi Jungil , Xu Shuai , Quaggin Susan , Ghaffari Roozbeh , Rogers John A.
Published: March 2019

Passive sweat collection and colorimetric analysis.
Edge-oriented MoS2 supported on nickel/carbon core–shell nanospheres for enhanced hydrogen evolution reaction performance
Authors: Wang Yin , Wang Zegao , Yang Qian , Hua An , Ma Song , Zhang Zhidong , Dong Mingdong
Published: March 2019

Edge-oriented molybdenum disulfide, growing on the surface of carbon shell with a nickel core, exhibits the enhanced performance on hydrogen evolution reaction.
An airtight-cavity-structural triboelectric nanogenerator-based insole for high performance biomechanical energy harvesting
Authors: Lin Zhiming , Wu Yufen , He Qiang , Sun ChenChen , Fan Endong , Zhou Zhihao , Liu Mingyang , Wei Wei , Yang Jin
Published: March 2019

A waterproof, high-output and airtight-cavity-airbag structural insole based on a TENG is presented to harvest human energy for driving wearable electronics.
Cell-membrane coated iron oxide nanoparticles for isolation and specific identification of drug leads from complex matrices
Authors: Sherwood Jennifer , Sowell Josiah , Beyer Nicholas , Irvin Jessica , Stephen Cayman , Antone Angelo J. , Bao Yuping , Ciesla Lukasz M.
Published: March 2019

New drug discovery technique to identify compounds binding to transmembrane receptors in complex mixtures.
Directed motion of water droplets on multi-gradient photopolymer surfaces
Authors: Rossegger E. , Hennen D. , Griesser T. , Roppolo I. , Schlögl S.
Published: March 2019

Rapid and directional movement of water droplets across a photopolymer surface with inscribed wettability and Laplace pressure gradient is demonstrated.
Fluorinated heptacyclic carbazole-based ladder-type acceptors with aliphatic side chains for efficient fullerene-free organic solar cells
Authors: Chen Tsung-Wei , Hsiao Yu-Tang , Lin You-Wei , Chang Chia-Chih , Chuang Wei-Tsung , Li Yongfang , Hsu Chain-Shu
Published: March 2019

Side chain engineering (phenyl side chains to aliphatic side chains) and fluorinated end groups (IC to 2FIC) are utilized to construct high performance NFA with high planarity.
A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles
Authors: Godoy-Reyes Tania M. , Llopis-Lorente Antoni , García-Fernández Alba , Gaviña Pablo , Costero Ana M. , Villalonga Reynaldo , Sancenón Félix , Martínez-Máñez Ramón
Published: March 2019

Janus Au–mesoporous silica nanoparticles functionalized withl-glutamate oxidase and self-immolative arylboronate as al-glutamate-responsive delivery system.
Oxidative dual C–H selenation of imidazoheterocycles with ethers or alkanes using selenium powder via a radical pathway
Authors: Guo Tao , Wei Xu-Ning , Liu Yu , Zhang Pan-Ke , Zhao Yun-Hui
Published: March 2019

A DCP-mediated oxidative dual C–H selenation radical reaction of imidazoheterocycles with ethers or alkanes using selenium powder was developed.
Structural characterization of Momordica charantia L. (Cucurbitaceae) oligopeptides and the detection of their capability in non-small cell lung cancer A549 cells: induction of apoptosis
Authors: Dong Jiao , Zhang Xianxin , Qu Chunxiao , Rong Xuedong , Liu Jie , Qu Yiqing
Published: March 2019

MCLO-12 induced apoptosis by up-regulating the ROS, activating the caspases expressions, suppressing the Trx system and subsequently activating a number of Trx-dependent pathways.
The effect of oxidation on the electronic properties of penta-graphene: first-principles calculation
Authors: Li Lin , Jin Kaixuan , Du Chunyan , Liu Xiaojie
Published: March 2019

Herein, using first-principles calculations, we systematically studied the effect of oxidation on the structural and electronic properties of penta-graphene.
Hyperpatulones A–F, polycyclic polyprenylated acylphloroglucinols from Hypericum patulum and their cytotoxic activities
Authors: Wu Zhong-Nan , Niu Qian-Wen , Zhang Yu-Bo , Luo Ding , Li Qing-Guo , Li Ying-Ying , Kuang Guang-Kai , He Li-Jun , Wang Guo-Cai , Li Yao-Lan
Published: March 2019

Six new PPAPs (1–6) were isolated from Hypericum patulum and compound 5 exhibited significant cytotoxicities on various tumor cell lines.
Enhanced photoluminescence of LEuH nanosheets: 2D photonic crystals self-assembled by core–shell SiO2@LEuH spheres
Authors: Wang Xinying , Feng Pingping , Shao Baiyi , Cui Fangming , Yang Xiaojing
Published: March 2019

A two-dimensional (2D) colloidal crystal of core–shell-structured SiO2@LEuH spheres was prepared and showed enhanced photoluminescence at 611 nm (5D0 → 7F2).
Acid and base catalysed reactions in one pot with site-isolated polyHIPE catalysts
Authors: Yavuz Erdem , Cherkasov Nikolay , Degirmenci Volkan
Published: March 2019

The highly porous polymers with interconnected windows (polyHIPE) are functionalised with tertiary amine and carboxyl groups to form basic and Brønsted acidic heterogeneous catalysts.
Self-healable poly(acrylic acid-co-maleic acid)/glycerol/boron nitride nanosheet composite hydrogels at low temperature with enhanced mechanical properties and water retention
Authors: Xue Shishan , Wu Yuanpeng , Guo Meiling , Xia Yuanmeng , Liu Dan , Zhou Hongwei , Lei Weiwei
Published: March 2019

A self-healable poly(acrylic acid-co-maleic acid) hydrogel at low temperature with excellent mechanical properties and water retention was fabricated.
Linear symmetric liquid crystal trimers exhibiting supramolecular chiral architectures
Authors: Oikawa Ryuji , Sasaki Haruna , Takanishi Yoichi , Sagisaka Masanobu , Yamamoto Jun , Yoshizawa Atsushi
Published: March 2019

Achiral linear trimers possessing odd-numbered spacers exhibited soft crystalline chiral conglomerate phases. The trimers with shorter spacers were found to form cylindrical tubes, whereas those with longer spacers toroidal pits.
Nanoscale palladium as a new benchmark electrocatalyst for water oxidation at low overpotential
Authors: Joya Khurram Saleem , Ehsan Muhammad Ali , Babar Noor-Ul-Ain , Sohail Manzar , Yamani Zain H.
Published: March 2019

An effcient electrocatalytic Pd system, preparedviathe AACVD method, is presented executing high activity water oxidation at 1.43 VvsRHE;η= 200 mV while exceeding the benchmark performance of IrO2.
Lithium bisoxalatodifluorophosphate (LiBODFP) as a multifunctional electrolyte additive for 5 V LiNi0.5Mn1.5O4-based lithium-ion batteries with enhanced electrochemical performance
Authors: Yang Tianxiang , Zeng Huanna , Wang Wenlian , Zhao Xiaoyang , Fan Weizhen , Wang Chengyun , Zuo Xiaoxi , Zeng Ronghua , Nan Junmin
Published: March 2019

Lithium bisoxalatodifluorophosphate (LiBODFP) is a promising multifunctional lithium salt-type electrolyte additive used to enhance the performance of 5 V LiNi0.5Mn1.5O4 (LNMO)-based lithium-ion batteries (LIBs).
A biodegradable polymer-based common chemical avenue for optimizing switchable, chemically reactive and tunable adhesive superhydrophobicity
Authors: Jana Nirban , Parbat Dibyangana , Mondal Barnali , Das Supriya , Manna Uttam
Published: March 2019

A biodegradable polymer-based, common and robust chemical approach is introduced for developing chemically reactive, tunable adhesion and stimuli-responsive superhydrophobicity through strategic use of residual acrylate and primary amine groups.
Ancillary ligand-assisted robust deep-red emission in iridium(iii) complexes for solution-processable phosphorescent OLEDs
Authors: Kim Hae Un , Jang Ho Jin , Choi Wanuk , Kim Minjun , Park Sungjin , Park Taiho , Lee Jun Yeob , K. S. Bejoymohandas
Published: March 2019

Two different kinds of ancillary ligands such as picolinate and thenoyltrifluoroacetylacetonate have profound effects on the excited state properties of deep red emissive iridium(iii) complexes
The Relationship Between Operational Competency, Buy-In, and Augmentative and Alternative Communication Use in School-Age Children With Autism
Authors: DeCarlo Jenna , Bean Allison , Lyle Samantha , Paden Miller Cargill Lindsey
Published: March 2019

Purpose

The objective of this study was to investigate the relationship between 2 variables that influence augmentative and alternative communication (AAC) use, caregiver operational competency (i.e., the ability to navigate, customize, and program the device), and AAC system buy-in (i.e., understanding that the device acts as the child's voice and should be treated as an extension of his or her physical body), to determine if there was a relationship between these variables and device use at home and at school in school-age children with autism who use AAC.

Method

The device use of 29 school-age children (
M
age
= 7.82 years) with an educational diagnosis of autism who use AAC was tracked using the logging feature on the participants' AAC devices. Participants' parents (
n
= 29) and teachers (
n
= 14, some teachers reported on multiple students) completed a questionnaire assessing caregiver operational competency and AAC system buy-in. Minutes of data use were extracted from each participant's AAC device (
Cross & Segalman, 2016
) and averaged across three randomly selected dates.

Results

The parents and teachers reported high rates of operational competency and buy-in. However, only 10 of the children used their devices at home during the weekends. Despite high rates of parent- and teacher-reported operational competency, participants did not use their devices at high rates.

Conclusion

Speech-language pathologists may also need to focus on other aspects of parent and teacher training, such as creating communication opportunities for students who use AAC to increase device use at home and at school.
Growth Effects on Velopharyngeal Anatomy From Childhood to Adulthood
Authors: Perry Jamie L. , Kollara Lakshmi , Sutton Bradley P. , Kuehn David P. , Fang Xiangming
Published: March 2019

Purpose

The observed sexual dimorphism of velopharyngeal structures among adult populations has not been observed in the young child (4- to 9-year-old) population. The purpose of this study was to examine the age at which sexual dimorphism of velopharyngeal structures become apparent and to examine how growth trends vary between boys and girls.

Method

Static 3-dimensional magnetic resonance imaging velopharyngeal data were collected among 202 participants ranging from 4 to 21 years of age. Participants were divided into 3 groups based on age, including Group 1: 4–10 years of age, Group 2: 11–17 years of age, and Group 3: 18–21 years of age. Nine velopharyngeal measures were obtained and compared between groups.

Results

Significant sex effects were evident for levator length (p= .011), origin to origin (p= .018), and velopharyngeal ratio (p= .036) for those in Group 2 (11–17 years of age). Sex effects became increasingly apparent with age, with 7 of 9 variables becoming significantly different between male and female participants in Group 3. Boys, in general, displayed a delayed growth peak in velopharyngeal growth compared to girls.

Conclusion

Results from this study demonstrate the growth of velopharyngeal anatomy with sexual dimorphism becoming apparent predominantly after 18 years of age. However, velopharyngeal variables displayed variable growth trends with some variables presenting sexual dimorphism at an earlier age compared to other velopharyngeal variables.
Eccentricity detection of a six‐phase induction motor with HFI
Authors: Wang Tong , Huang Jin , Lin Benhong , Kang Min , Chen Jiahao , Kong Wubin
Published: March 2019

Eccentricity detection is an important topic in motor fault diagnosis and bearingless motor controls. In this study, a novel method is proposed for eccentricity detection of a six‐phase motor based on high‐frequency injection (HFI). Unlike the other planes of the multiphase motors, the 0_ component (the average of the differences between adjacent phases) is seldom adopted for signal injections. The proposed method exploits the 0_ component for signal injection which allows the injected signals to be decoupled from the rotating‐magnetic‐field‐producing planes without occupying any of them (so that they can be assigned to other uses). In this study, the induction motor under HFI is simplified as a model with mutually decoupled winding pairs. The HF impedance of each phase under eccentricity is derived on the basis of this model. The proposed method is drawn from these theories and verified with experiments. It is shown in the experiments that the proposed method has excellent linearity; the estimations on orthogonal directions are decoupled; and the proposed method has satisfactory tracking bandwidth. The influence of saturation on the proposed method is justified by simulations. The capability of the proposed method to discriminate between different types of eccentricities is proved with experimental data.
TM11 to HE11 mode converter in overmoded circular corrugated waveguide
Authors: Patel Amit , Goswami Riddhi , Bhatt Pujita , Mewada Hiren , K Sathyanarayana , Kulkarni S
Published: March 2019

The proposed study contains the design and analysis of TM11 to HE11 (hybrid) mode converter at 42±0.2 GHz which is an integral component of the transmission line that transmits 200 kW power from gyrotron to the plasma in SST‐1 Aditya tokamak. HE11 mode is preferred, as the transmission loss in corrugated waveguide is less in comparison with other modes. For generating HE11 mode from TM11 mode, the depth of the annular slots in the mode converter is varied gradually from zero to one‐quarter wavelength. The conversion efficiency and radiation pattern of the proposed mode converter depends on the corrugation profile and the length of the mode converter. Both the parameters are optimised numerically to achieve the highest conversion efficiency. Keeping in mind mechanical fabrication of mode converters optimisation has been carried out. It converts 95.6% power of TM11 mode into HE11 (82.2% TE11+13.4% TM11) mode respectively. The 1 dB compression bandwidth of 19.04% (8 GHz) at 42 GHz is obtained. The length of mode converter is 40.83λ mm. The reflection coefficient and VSWR are −25 dB and 1.1 respectively. The power in side lobes and isolation from cross polar component is less than −20 dB and −25 dB respectively.
Sensitivity Analysis of Helical Gears with Tooth Surface Modification to Applied Torque and Gear Misalignment
Authors: Yuan Bing , Chang Shan , Liu Geng , Liu Lan , Chang Lehao
Published: March 2019

The numerical calculation model of time-varying mesh stiffness, static transmission error and composite mesh error of modified helical gears is developed based on loaded tooth contact analysis (LTCA) model. To minimize the fluctuation of vibration excitation force, the optimal modification parameters of three modification methods under designed applied torque and ideal tooth contact condition are determined, and the effects of three modification methods on time-varying mesh stiffness, static transmission error and composite mesh error are analyzed. In order to analyze the sensitivity of the three modification methods to applied torque and gear misalignment, the effects of applied torque in wide range and gear misalignment on vibration excitation force and dynamic transmission error are investigated. The results show that the difference of time-varying mesh stiffness, static transmission error, composite mesh error of helical gears with different modifications methods are obvious. However, the fluctuation of vibration excitation force of helical gears is reduced significantly. When the applied torque is higher than the designed applied torque, the three modification methods show a great reduction of system vibration. When the applied torque is too low, the vibration of modified helical gears is larger than unmodified ones. Meanwhile, the resonance speed of the helical gears is slightly lower. With the increase of gear misalignment, the resonance speed becomes lower correspondingly and the effect of the three modification methods on the reduction of vibration excitation force is not obvious any more. The results can provide effective reference for establishing robust optimization method for tooth surface modification.
A Battlefield Target Grouping Method Based on M-CFSFDP Algorithm
Authors: Li Weinan , Zhang Weiguo , Shi Jingping , Wu Yunyan
Published: March 2019

Target grouping can divide battlefield targets into battle space groups. In this way, the target grouping reduces the difficulty of situation assessment and increases the efficiency of decision. In order to solve the target grouping, a target grouping method based on Manifold-CFSFDP algorithm is proposed. This method turns target grouping into dataset clustering. After calculating the manifold which measures the similarity of targets, it searches the clustering centers and classifies the other data points by CFSFDP based on manifold. The simulation experiment for artificial and UCI datasets proves that M-CFSFDP is more effective than CFSFDP. The correctness and feasibility of M-CFSFDP are also shown by static and dynamic grouping of battlefield targets.
Study on the Performance of a Quasi-Zero-Stiffness Isolator with Time Delay Control
Authors: Li Donghai , Zhao Shougen , He Yujin , Li Tao
Published: March 2019

A quasi-zero-stiffness vibration isolation consists of a pair of oblique springs and a vertical spring, aiming at widening the vibration isolation region, is studied in this paper. The time delay linear displacement feedback control strategy is introduced to improve the performance of the isolator. The characteristics of dynamical response under harmonically forcing excitation is obtained by using averaging method. The force transmissibility of the control isolator is presented in this paper. The influence of the time delay linear displacement control on the force transmissibility is studied theoretically. The results show that the performance of the vibration isolation with time-delay control is better than the equivalent linear isolator in either low or high frequency region and the performance of controlled system is better than uncontrolled system.
An example of design, optimization, stabilization and noise performances of resonator-based optoelectronic oscillators
Authors: Salzenstein Patrice
Published: March 2019

In this paper we talk about oscillators of optoelectronic type with intensity modulators and high-quality optical resonators technology. This subject is illustrated by an example of realization from the material to the characterization of the realized oscillator. It is explained how such an oscillator is designed and how it can be optimized.