bluuebunny/crossref_metadata_2025 huggingface dataset:
Mediating Role of Environmental Awareness for the Nexus between Perceived Risks of COVID-19 Pandemic and Use of Sustainable Transportation: Evidence from Urban Passengers in Ethiopia, 2022
Authors: Tareke Kassa Moges
Published: March 2024

The COVID-19 pandemic has been a global pandemic and a threat to humankind. In addition to many cases of illness and millions of deaths, the economy and social interactions have suffered. It remarkably declined overall transportation and mobility in most countries. However, given that there is a gap between environmental sustainability awareness and what is practiced by transport users, the goal of this study was to empirically assess the mediating role of environmental awareness in the casual links between perceived risks of the COVID-19 pandemic and ecologically sustainable transportation use. The study identified relevant theories, conceptual frameworks, and variables. Mixed research and surveys were carried out on the public and private transport service users in Addis Ababa, Ethiopia. Comparative analysis, structural equation modeling, and structural causal model framework were applied to estimate casual relationships among variables and test the hypotheses. Despite the rising of human-caused climate change denial beliefs, findings revealed that a large part of the causes of the COVID-19 pandemic are climate change, biodiversity misuse, and wildlife degradation, all of which are environmental in nature and anthropogenic. People perceived the COVID-19 pandemic as more of a risk to others than to themselves, and climate change or global warming has become a danger to humanity, mainly during the pandemic. Accordingly, the pandemic risks increased people’s mainly passengers’ awareness of the environment, and this caused them to give greater consideration to the environmentally attractiveness of the transport they use. This, in turn, encouraged people to take personal climate-friendly measures and pro-environmental behavior, mainly greater willingness to use public transportation than private transportation during the COVID-19 pandemic than before. Thus, the total effect of the COVID-19 pandemic anxiety on the use of public transportation is completely mediated by enhanced environmental awareness. These are evidence that COVID-19 has strengthened environmental awareness and promoted sustainable action in the context of the transportation industry of developing countries. The study informs that urban planning and policy need to consider pandemic-sensitive and innovative public health and transport systems, integrated public health education, one health approach, and smart city. It suggests that maintaining the environmental awareness of societies and encouraging them to mitigate climate change through urgent climate actions and modal shifts to the use of sustainable urban transport such as public transportation.
Latent Classes of Personality Traits and Their Relationship with Workplace Bullying among Acute and Critical Care Nurses
Authors: Sun Meng , Han Jing , Qiao Ying , Wang Juan , Jiang Mei , Zhang Min
Published: March 2024

Objective. To identify the latent classes of personality traits among nurses in acute and critical care departments, as well as the relationship between latent classes of different personality traits and workplace bullying. Methods. A total of 245 nurses working in the acute and critical care department at a 3 A-grade hospital in Shandong Province, China, were recruited by convenient sampling. The Chinese Big Five Personality Inventory brief version was used to assess personality traits, and the Negative Acts Questionnaire was used to measure workplace bullying. Latent profile analysis was used to identify the latent classes of personality traits. Multiple linear regression analysis was used to examine the relationship between latent classes of personality traits and workplace bullying. Results. Four latent classes of personality traits among acute and critical care nurses were identified, namely, the negative group (49.0%), flexible group (16.0%), neurotic group (18.1%), and stable group (16.9%), respectively. Compared with the neurotic group, the negative group (B = −6.227, P<0.05), stable group (B = −16.562, P<0.001), and flexible group (B = −19.208, P<0.001) experienced less workplace bullying. Conclusion. Our findings explore latent classes of personality traits among acute and critical care nurses, identify subgroups susceptible to workplace bullying, and suggest the development of appropriate interventions to reduce workplace bullying. Implications for Nursing Management. Hospital managers can identify nurses who are prone to workplace bullying based on their personality traits and provide them with psychological counseling services and psychological healing groups to help them establish good interpersonal relationships and maintain their mental and physical health.
Low Dose Pregabalin Improves Gastrointestinal Symptoms of Crohn’s Disease
Authors: D’Onofrio Antonio Maria , Di Vincenzo Federica , Ferrajoli Gaspare Filippo , Scaldaferri Franco , Camardese Giovanni
Published: March 2024

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are lifelong conditions with no definite cure. Several studies demonstrated that patients with IBD more frequently experience symptoms of common mental disorders, such as anxiety and depression, because of bidirectional communication through the gut-brain axis and the chronicity of symptoms, as well as because of impaired quality of life and reduced social functioning. However, psychological conditions of affected patients are often underestimated and not fully considered. Herein, we present the case of a 37-year-old woman with Crohn’s disease and a mild depressive condition, characterized by anxious distress, tachycardia, tachypnea, tremors, sweating, avoidant behaviors, and intestinal somatizations (diarrhea), who was treated with Pregabalin upon indication of the referring psychiatrist. Following the beginning of the treatment, the patient rapidly reported an improvement in the overall clinical symptoms as well as a better management of psychic and physical anxiety with a marked reduction in diarrheal discharges under stress at work. After 6 months of Pregabalin therapy, we additionally observed an improvement in Crohn’s disease activity, both clinically, in the laboratory, and endoscopically. Our case showed that patients with Crohn’s disease and anxiety problems may benefit from low-dose Pregabalin medication to improve both their mental and physical condition.
Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory
Authors: Ohseto Hisashi , Takahashi Ippei , Narita Akira , Obara Taku , Ishikuro Mami , Kobayashi Natsuko , Kikuchi Saya , Li Xue , Noda Aoi , Murakami Keiko , Tamiya Gen , Sugawara Junichi , Tomita Hiroaki , Kuriyama Shinichi
Published: March 2024

This study is aimed at revealing the risk factors, prognosis, influence on offspring, and genetic architecture of perinatal depression (PD) classified based on the depressive symptom trajectory. Pregnant women with no history of major depressive disorder (MDD) were recruited and followed up with their offspring from 1 to 5 years postpartum. Using four self-report questionnaires in the perinatal period, PD was classified into four subtypes: pregnancy, early postpartum, late postpartum, and chronic PD. Risk factors, depressive symptom trajectory from 1 to 5 years postpartum, and child behavior problems were compared among the four PD subtypes. Genome-wide association studies (GWASs) were conducted for each subtype. The relationships between the PD subtypes and polygenic risk scores (PRS) for MDD, a psychiatric disorder, and premenstrual syndrome (PMS), a hormonal disorder, were examined. Among 12,338 participants, 1,145 (9.3%) developed pregnancy PD, 856 (6.9%) developed early postpartum PD, 382 (3.1%) developed late postpartum PD, and 1,048 (8.5%) developed chronic PD. Depressive symptoms decreased to 61.0%–73.3% in the 5 years postpartum. The relationship between risk factors and PD varied based on the PD subtype. Additionally, chronic PD increased the risk of child behavior problems by 2- to 3-fold. The GWASs uncovered five significant variants in different loci depending on PD subtypes, suggesting a subtype-specific genetic architecture. The PRS for MDD was related to pregnancy, early postpartum, and chronic PD, while that for PMS was related to late postpartum PD. It was concluded that PD is heterogeneous depending on the depressive symptom trajectory. Thus, specific prevention and treatment strategies are needed.
Evaluation of Features in Probably Benign and Malignant Nonmass Enhancement in Breast MRI
Authors: Ahmadinejad Nasrin , Azizinik Fahimeh , Khosravi Pershang , Torabi Ala , Mohajeri Amirhassan , Arian Arvin
Published: March 2024

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a highly sensitive breast imaging modality in detecting breast carcinoma. Nonmass enhancement (NME) is uniquely seen on MRI of the breast. The correlation between NME features and pathologic results has not been extensively explored. Our goal was to evaluate the characteristics of probably benign and suspicious NME lesions in MRI and determine which features are more associated with malignancy. We performed a retrospective research after approval by the hospital ethics committee on women who underwent breast MRI from March 2017 to March 2020 and identified 63 lesions of all 400 NME that were categorized as probably benign or suspicious according to the BI-RADS classification (version 2013). MRI features of NME findings including the location, size, distribution and enhancement pattern, kinetic curve, diffusion restriction, and also pathology result or 6-12-month follow-up MRI were evaluated and analyzed in each group (probably benign or suspicious NME). Vacuum-guided biopsies (VAB) were performed under mammographic or sonographic guidance and confirmed with MRI by visualization of the inserted clips. Segmental distribution and clustered ring internal enhancement were significantly associated with malignancy (p value<0.05), while linear distribution or homogeneous enhancement patterns were associated with benignity (p value <0.05). Additionally, the plateau and washout types in the dynamic curve were only seen in malignant lesions (p value <0.05). The presence of DWI restriction in NME lesions was also found to be a statistically important factor. Understanding the imaging findings of malignant NME is helpful to determine when biopsy is indicated. The correlation between NME features and pathologic results is critical in making appropriate management.
Comparison of Chemically Treated, Pasteurized, and Microwave-Treated (at Different Time Durations) Chia Seeds Added To Mango-Whey Beverage, during Different Storage Periods, for Physicochemical and Sensory Parameters
Authors: Siddique Farzana , Hussain Ashiq , Mahdi Amer Ali , Hassan Mansoor , Noreen Saima , Siddique Tahira , Batool Syeda Ayesha , Yaqub Shazia , Gorsi Faiza Iftikhar , Kauser Samina , Fatima Haya , Korma Sameh A.
Published: March 2024

Foods that are widely consumed and accepted have had a lot of ingredients added to them which may enhance consumer’s health. Whey is a byproduct in the manufacture of cheese or curd and is widely used in different beverage formulations, due to its nutritional importance. In this context, a mango-based functional whey drink, added with omega-3-rich chia seeds, was de veloped. Different treatments of beverage were as follows: untreated control beverage (T0), application of chemicals (T1), pasteurization (T2), and microwave heating (at 4 different time lengths: T3, T4, T5, and T6). Beverages were analyzed for physiochemical, microbiological, and sensorial changes, during the 90 days of storage. Chemical analysis of chia seeds before incorporation in beverages revealed a high nutritional profile of chia seeds, especially the presence of essential fatty acids. Significant variation in color parameters of the beverage was observed as a result of treatments and storage, with optimum values observed for T3. A decrease in pH and an increase in acidity during storage for all treatments were evident, with the most significant results for microwave treatment for longer time periods. The total plate count of the beverage was the highest (2.36 ± 0.1 CFU/ml) for control, followed by chemically treated (2.17 ± 0.1 CFU/ml) and lowest in microwave-treated (0.98 ± 0.1 CFU/ml) at the start of the experiment, and this total plate count was found to be increasing in all treatments during storage. Total solids were increased and soluble solids were decreased during longer microwave treatments and also during storage of all treatments. The most acceptable treatment T3 (85 ml whey, 2 g chia seed, and microwave heating for 30 sec) was further subjected to a storage study and it was observed that the sensory scores gradually decreased during the 90 days of storage. From the outcomes of the study, it was concluded that microwave treatment of the beverage for 30 sec, as compared to longer durations and chemical preservatives, was proved helpful for optimum quality retention of the formulated beverage, with minimum deteriorating effects. Thus, proper treatments of different beverage formulations, following the necessary protocols, could provide the consumers safe, healthy, and nutritious beverages.
Ultrasound Assessment of Carotid Intima-Media Thickness: Comparison between Diabetes and Nondiabetes Subjects, and Correlation with Serum Vitamin D
Authors: Rashid Sameeah Abdulrahman
Published: March 2024

Background and Objective. Diabetes contributes to considerable morbidity and mortality through vascular complications. Sonographic evaluation of carotid intima-media thickness (CIMT) is accepted as a surrogate marker for atherosclerosis. The aim of this study was to find out the difference in the CIMT between diabetes and nondiabetes and determine its correlation with serum vitamin D and some other modifiable and nonmodifiable cardiovascular risk factors. Methods. This multicenter cross-sectional study was performed on two groups of adults (nondiabetes and type 2 diabetes) of various ages, sexes, and body mass index (BMI). CIMT for each side was measured at three segments using high-resolution ultrasound, and the mean of both sides was determined. Comparison was made between each group, and the association of CIMT with each of age, sex, BMI, serum vitamin D status, smoking, and physical activity status was studied. The chi-square test was used to compare categorical data, and binary logistic regression was utilized to ascertain the relationship between CIMT and the study variables. Results. A significant difference was observed between the CIMT of the diabetes and nondiabetes group, average CIMT was 0.82 ± 0.23 mm vs. 1.12 ± 0.24 mm for the nondiabetes and diabetes group, respectively, with P value <0.005. No significant correlation was observed between serum vitamin D level and CIMT neither in the study group as a whole nor in either subgroup; however, a significant association was observed between CIMT with each of age, sex, BMI, smoking, and physical activity status. Conclusion. Ultrasound is a sensitive tool for CIMT evaluation. Diabetes has a 5.4-fold higher risk of having high CIMT. Serum vitamin D level showed no significant influence on CIMT. Smoking, BMI, and physical activity are among the modifiable risk factors with significant influence on CIMT.
Figure S1 from Post-translational Modification of PD-1: Potential Targets for Cancer Immunotherapy
Authors: Lee Te-An , Tsai En-Yun , Liu Shou-Hou , Hsu Hung Shih-Duo , Chang Shing-Jyh , Chao Chi-Hong , Lai Yun-Ju , Yamaguchi Hirohito , Li Chia-Wei
Published: March 2024

The biological function of PD-1 on immune cells and cancer cells
Supplementary Tables from FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Supplementary Tables
Figure S7 from FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Figure S7
Figure S2 from FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Figure S2
Figure S1 from FASN Inhibition Decreases MHC-I Degradation and Synergizes with PD-L1 Checkpoint Blockade in Hepatocellular Carcinoma
Authors: Huang Jiao , Tsang Wai Ying , Fang Xiao-Na , Zhang Yu , Luo Jie , Gong Lan-Qi , Zhang Bai-Feng , Wong Ching Ngar , Li Zhi-Hong , Liu Bei-Lei , Huang Jin-Lin , Yang Yu-Ma , Liu Shan , Ban Liu-Xian , Chan Yiu Hong , Guan Xin-Yuan
Published: March 2024

Figure S1
Figure S2 from A Cluster of Evolutionarily Recent KRAB Zinc Finger Proteins Protects Cancer Cells from Replicative Stress–Induced Inflammation
Authors: Martins Filipe , Rosspopoff Olga , Carlevaro-Fita Joana , Forey Romain , Offner Sandra , Planet Evarist , Pulver Cyril , Pak HuiSong , Huber Florian , Michaux Justine , Bassani-Sternberg Michal , Turelli Priscilla , Trono Didier
Published: March 2024

Related to Figure 2: A module of KZFP genes in DLBCLs with cell-autonomous growth features.
Supplementary Data from Foretinib Is Effective in Acute Myeloid Leukemia by Inhibiting FLT3 and Overcoming Secondary Mutations That Drive Resistance to Quizartinib and Gilteritinib
Authors: Wang Peihong , Zhang Yvyin , Xiang Rufang , Yang Jie , Xu Yanli , Deng Tingfen , Zhou Wei , Wang Caixia , Xiao Xinhua , Wang Shunqing
Published: March 2024

Supplementary Data
Table S1 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Processed sequencing data of m6A-seq, Rip-seq, Ribo-seq and RNA-seq
Supplementary Fig. S5 from AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Authors: Huang Tzu-Ting , Chiang Chih-Yuan , Nair Jayakumar R. , Wilson Kelli M. , Cheng Ken , Lee Jung-Min
Published: March 2024

Supplementary Fig. S5
Supplementary Data from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Supplementary methods and tables
Figure S6 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S6
Figure S3 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S3
Figure S2 from N6-Methyladenosine Reader YTHDF1 Promotes Stemness and Therapeutic Resistance in Hepatocellular Carcinoma by Enhancing NOTCH1 Expression
Authors: Zhang Xinyue , Su Tianhong , Wu Yifan , Cai Yuhong , Wang Lina , Liang Cong , Zhou Lei , Wang Shiyan , Li Xiao-Xing , Peng Sui , Kuang Ming , Yu Jun , Xu Lixia
Published: March 2024

Figure S2
Supplementary Data from Inhibition of Ephrin B2 Reverse Signaling Abolishes Multiple Myeloma Pathogenesis
Authors: Sasine Joshua P. , Kozlova Natalia Y. , Valicente Lisa , Dukov Jennifer , Tran Dana H. , Himburg Heather A. , Kumar Sanjeev , Khorsandi Sarah , Chan Aldi , Grohe Samantha , Li Michelle , Kan Jenny , Sehl Mary E. , Schiller Gary J. , Reinhardt Bryanna , Singh Brijesh Kumar , Ho Ritchie , Yue Peibin , Pasquale Elena B. , Chute John P.
Published: March 2024

Supplementary Figures
Data from A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma
Authors: Hwang Grace H. , Pazyra-Murphy Maria F. , Seo Hyuk-Soo , Dhe-Paganon Sirano , Stopka Sylwia A. , DiPiazza Marina , Sutter Nizhoni , Gero Thomas W. , Volkert Alison , Ombelets Lincoln , Dittemore Georgia , Rees Matthew G. , Ronan Melissa M. , Roth Jennifer A. , Agar Nathalie Y.R. , Scott David A. , Segal Rosalind A.
Published: March 2024

Abstract
Medulloblastoma is one of the most common malignant brain tumors of children, and 30% of medulloblastomas are driven by gain-of-function genetic lesions in the Sonic Hedgehog (SHH) signaling pathway. EYA1, a haloacid dehalogenase phosphatase and transcription factor, is critical for tumorigenesis and proliferation of SHH medulloblastoma (SHH-MB). Benzarone and benzbromarone have been identified as allosteric inhibitors of EYA proteins. Using benzarone as a point of departure, we developed a panel of 35 derivatives and tested them in SHH-MB. Among these compounds, DS-1–38 functioned as an EYA antagonist and opposed SHH signaling. DS-1–38 inhibited SHH-MB growth in vitro and in vivo, showed excellent brain penetrance, and increased the lifespan of genetically engineered mice predisposed to fatal SHH-MB. These data suggest that EYA inhibitors represent promising therapies for pediatric SHH-MB.
Significance:
Development of a benzarone derivative that inhibits EYA1 and impedes the growth of SHH medulloblastoma provides an avenue for improving treatment of this malignant pediatric brain cancer.
Supplementary Table S2 from Monitoring Minimal Residual Disease in Patients with Multiple Myeloma by Targeted Tracking Serum M-Protein Using Mass Spectrometry (EasyM)
Authors: Fan Huishou , Wang Bing , Shi Lihui , Pan Ni , Yan Wenqiang , Xu Jingyu , Gong Lixin , Li Lingna , Liu Yuntong , Du Chenxing , Cui Jian , Zhu Guoqing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Hao Mu , Zou Dehui , Chen Xiequn , Qiu Lugui , An Gang
Published: March 2024

Panels of NGF detection in our study.
Supplementary Methods S1 from Monitoring Minimal Residual Disease in Patients with Multiple Myeloma by Targeted Tracking Serum M-Protein Using Mass Spectrometry (EasyM)
Authors: Fan Huishou , Wang Bing , Shi Lihui , Pan Ni , Yan Wenqiang , Xu Jingyu , Gong Lixin , Li Lingna , Liu Yuntong , Du Chenxing , Cui Jian , Zhu Guoqing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Hao Mu , Zou Dehui , Chen Xiequn , Qiu Lugui , An Gang
Published: March 2024

M-protein digestion and quantification by mass spectrometry
Supplementary Table S1 from The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
Authors: Halabi Susan , Guo Siyuan , Park Joseph J. , Nanus David M. , George Daniel J. , Antonarakis Emmanuel S. , Danila Daniel Costin , Szmulewitz Russell Zelig , McDonnell Donald P. , Norris John D. , Lu Changxue , Luo Jun , Armstrong Andrew J.
Published: March 2024

Baseline characteristics of the patients by Adnatest CTC and CellSearch CTC detection
Supplementary Figure S4 from Early Detection of Molecular Residual Disease and Risk Stratification for Children with Acute Myeloid Leukemia via Circulating Tumor DNA
Authors: Liu Li-Peng , Zong Su-Yu , Zhang Ao-Li , Ren Yuan-Yuan , Qi Ben-Quan , Chang Li-Xian , Yang Wen-Yu , Chen Xiao-Juan , Chen Yu-Mei , Zhang Li , Zou Yao , Guo Ye , Zhang Ying-Chi , Ruan Min , Zhu Xiao-Fan
Published: March 2024

Figure S4. The correlation of the VAFs in the patient-specific tumor mutation site detected in plasma ctDNA and matched MFC based MRD. Scatter plot of the 195 individual mutations detected by both methods (r=0.586, p<0.001).
Supplementary Table S2 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Primer sequences for selected genes in qRT-PCR analysis
Supplementary Material and Methods S1 from Preclinical Evaluation of NTX-301, a Novel DNA Hypomethylating Agent in Ovarian Cancer
Authors: Wang Yinu , Situ Xiaolei , Cardenas Horacio , Siu Ellie , Alhunayan Sayedabdulrazzaq A. , Keathley Russell , Tanner Edward , Wei Jian-Jun , Tan Yuying , Prabhu Dessai Chinmayee Vallabh , Cheng Ji-Xin , Matei Daniela
Published: March 2024

Supplementary Material and Methods
Figure S4 from An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer
Authors: Lukovic Jelena , Pintilie Melania , Han Kathy , Fyles Anthony W. , Bruce Jeffrey P. , Quevedo Rene , Pugh Trevor J. , Fjeldbo Christina S. , Lyng Heidi , Milosevic Michael F.
Published: March 2024

Figure S4
Figure S2 from An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer
Authors: Lukovic Jelena , Pintilie Melania , Han Kathy , Fyles Anthony W. , Bruce Jeffrey P. , Quevedo Rene , Pugh Trevor J. , Fjeldbo Christina S. , Lyng Heidi , Milosevic Michael F.
Published: March 2024

Figure S2
Table S2 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Table S2. siRNA, miRNA mimics and antagomir used.
Figure S7 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S7. A-NDEs reduce the m6A level in microglia.
Figure S4 from Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation
Authors: Guo Xiaofan , Qiu Wei , Li Boyan , Qi Yanhua , Wang Shaobo , Zhao Rongrong , Cheng Bo , Han Xiao , Du Hao , Pan Ziwen , Zhao Shulin , Qiu Jiawei , Li Gang , Xue Hao
Published: March 2024

Figure S4. hM3Dq activated neurons promote microglial M2 polarization through exosomes.
Supplementary Figure S3 from Phase II Study of Durvalumab Immediately after Completion of Chemoradiotherapy in Unresectable Stage III Non–small Cell Lung Cancer: TORG1937 (DATE Study)
Authors: Nakamichi Shinji , Kubota Kaoru , Misumi Toshihiro , Kondo Tetsuro , Murakami Shuji , Shiraishi Yoshimasa , Imai Hisao , Harada Daijiro , Isobe Kazutoshi , Itani Hidetoshi , Takata Saori , Wakui Hiroshi , Misumi Yuki , Ikeda Satoshi , Asao Tetsuhiko , Furuya Naoki , Hosokawa Shinobu , Kobayashi Yumiko , Takiguchi Yuichi , Okamoto Hiroaki
Published: March 2024

Onset and grade of pneumonitis
Supplementary Figure S1 from Phase II Study of Durvalumab Immediately after Completion of Chemoradiotherapy in Unresectable Stage III Non–small Cell Lung Cancer: TORG1937 (DATE Study)
Authors: Nakamichi Shinji , Kubota Kaoru , Misumi Toshihiro , Kondo Tetsuro , Murakami Shuji , Shiraishi Yoshimasa , Imai Hisao , Harada Daijiro , Isobe Kazutoshi , Itani Hidetoshi , Takata Saori , Wakui Hiroshi , Misumi Yuki , Ikeda Satoshi , Asao Tetsuhiko , Furuya Naoki , Hosokawa Shinobu , Kobayashi Yumiko , Takiguchi Yuichi , Okamoto Hiroaki
Published: March 2024

CONSORT diagram
Supplementary Figure S4 from Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade
Authors: Tabachnick-Cherny Shira , Pulliam Thomas , Rodriguez Haroldo J. , Fan Xinyi , Hippe Daniel S. , Jones Daniel C. , Moshiri Ata S. , Smythe Kimberly S. , Kulikauskas Rima M. , Zaba Lisa C. , Paulson Kelly G. , Nghiem Paul
Published: March 2024

Immune lineage analysis of tumor infiltrating cells, by patient response to immunotherapy.
Data from Transverse Colon Primary Tumor Location as a Biomarker in Metastatic Colorectal Cancer: A Pooled Analysis of CCTG/AGITG CO.17 and CO.20 Randomized Clinical Trials
Authors: Solar Vasconcelos Joao Paulo , Chen Nan , Titmuss Emma , Tu Dongsheng , Brule Stephanie Y. , Goodwin Rachel , Jonker Derek J. , Price Timothy , Zalcberg John R. , Moore Malcolm J. , Karapetis Christos S. , Siu Lillian , Shapiro Jeremy , Simes John , Gill Sharlene , O'Callaghan Chris J. , Loree Jonathan M.
Published: March 2024

AbstractPurpose:
Sidedness is prognostic and predictive of anti-EGFR efficacy in metastatic colorectal cancer (mCRC). Transverse colon has been historically excluded from several analyses of sidedness and the optimal division between left- and right-sided colorectal cancer is unclear. We investigated transverse colon primary tumor location as a biomarker in mCRC.
Experimental Design:
Pooled analysis of CCTG/AGITG CO.17 and CO.20 trials of cetuximab in chemotherapy-refractory mCRC. Outcomes of patients with RAS/BRAF wild-type (WT) mCRC from CO.17 and KRAS WT mCRC from CO.20 were analyzed according to location.
Results:
A total of 553 patients were analyzed, 32 (5.8%) with cancers from the transverse, 101 (18.3%) from right, and 420 from (75.9%) left colon. Transverse mCRC failed to reach significant benefit from cetuximab versus best supportive care (BSC) for overall survival [OS; median, 5.9 vs. 2.1 months; HR, 0.63; 95% confidence interval (CI), 0.28–1.42; P=0.26] and progression-free survival (PFS; median, 1.8 vs. 1.3 months; HR, 0.57; 95% CI, 0.26–1.28; P=0.16). Analyzing exclusively patients randomized to cetuximab, right-sided and transverse had comparable outcomes for OS (median, 5.6 vs. 5.9 months; HR, 0.82; 95% CI, 0.50–1.34; P=0.43) and PFS (median, 1.9 vs. 1.8 months; HR, 0.78; 95% CI, 0.49–1.26; P=0.31). Patients with left-sided mCRC had superior outcomes with cetuximab compared with transverse for OS (median, 9.7 vs. 5.9 months; HR, 0.42; 95% CI, 0.27–0.67; P=0.0002) and PFS (median, 3.8 vs. 1.8 months; HR, 0,49; 95% CI, 0.31–0.76; P=0.001). Location was not prognostic in patients treated with BSC alone.
Conclusions:
Transverse mCRC has comparable prognostic and predictive features with right-sided mCRC.
Supplementary Tables from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

All supplementary tables.
Figure S9 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Supplementary figure 9 and legend.
Figure S7 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Supplementary figure 7 and legend.
FIGURE 4 from Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models
Authors: Sahovaler Axel , Valic Michael S. , Townson Jason L. , Chan Harley H.L. , Zheng Mark , Tzelnick Sharon , Mondello Tiziana , Pener-Tessler Alon , Eu Donovan , El-Sayes Abdullah , Ding Lili , Chen Juan , Douglas Catriona M. , Weersink Robert , Muhanna Nidal , Zheng Gang , Irish Jonathan C.
Published: March 2024

Histologic examination of intratumoral PS nanoparticle accumulation and mechanisms of PS-PDT damage in tumor-bearing mice models of oral cavity cancer. A, Brightfield images of the pathophysiology of Cal-33 xenograft tumors (top) and syngeneic MOC22 tumors (bottom). Scale bars = 250 µm. B, Imaging of PS nanoparticle intratumoral distribution using fluorescence microscopy (PS signal labeled “Pyro”) and tissue autoradiography of 64Cu-labeled PS radioactivity in Cal-33 (top) and MOC22 (bottom) tumors. Scale bars = 1,000 µm. Note that labeling PS with 64Cu permit radiotracing of PS pharmacokinetics in tissues and cells using radioactivity (Supplementary Fig. S1). Additional histologic images of other mouse organs are provided in Supplementary Fig. S4. C, Quantitative spatial analysis of cellular proximity of Pyro+ cells to CD31+ cells (CD31←Pyro) and of PIMO+ cells to CD31+ cells (CD31←PIMO) in Cal-33 and MOC22 tumors. Units µm. Scatter plot of individual replicates (●) with median distance identified by red line. N = 4–5 tumors/model. Additional quantitative intratumoral spatial analysis data provided in Supplementary Fig. S5. D, Histologic evidence of antitumor response in a Cal-33 xenograft tumor 72 hours after PS-PDT treatment (10 mg/kg, 24 hours DLI, 100 J/cm2, 100 mW/cm2). Scale bars = 500 µm. E, Quantification of histopathologic photodamage 72 hours post-treatment of Cal-33 tumor xenograft using apoptosis marker cleaved caspase-3. Units %. Mean ± SD. N = 3–4 tumors/treatment group. Additional statistical analysis is provided in Supplementary Table S8. H&E, hematoxylin and eosin (stain for tissue microanatomy and cellular morphology); CD31, cluster of differentiation 31 (marker for vascular/endothelial cell); PIMO, pimonidazole (fluorescent marker for tissue hypoxia); DAPI, 4′,6-diamidino-2-phenylindole (nuclear DNA fluorescent marker); Pyro (fluorescent marker for PS nanoparticles); 64Cu tissue autoradiography (intensity marker for 64Cu-labeled PS concentration in tissues); �lls Marker+ (percent of nucleated cells positive for marker of interest in tumor cross-section); TUNEL (DNA fragmentation marker).
Ambulatory Routine Care in Oncology in Germany: Real-World Survival Data
Authors: Marschner Norbert , Knauf Wolfgang
Published: March 2024

Introduction: Survival data reported by randomised controlled trials are collected in a highly selected patient population and can thus only be transferred to a limited extent to real-world patients: the patients in routine care are mostly older, present with more comorbidities and a worse general state of health. This so-called efficacy-effectiveness gap typically results in inferior survival data in routine healthcare. Methods: Six prospective clinical tumour registries recruited a total of 11,679 patients receiving systemic therapy in haemato-oncological practices in Germany between 2006 and 2020. For these patients with advanced colorectal cancer, breast cancer, lung cancer, pancreatic cancer, renal cell cancer, and lymphatic neoplasms, overall survival was analysed. A comprehensive literature search was performed to identify suitable pivotal randomised controlled trials. Results: Median overall survival of patients treated in German routine care, with advanced colorectal, breast, lung, and pancreatic cancer, as well as with diffuse large B‐cell lymphoma and multiple myeloma, is not shorter than the respective survival data reported in trials. Patients with advanced renal cell carcinoma, chronic lymphocytic leukaemia, or indolent non-Hodgkin lymphoma showed slightly lower survival rates compared to clinical trials. Conclusions: Despite less favourable patient characteristics, survival data from patients with cancer treated in ambulatory routine care in Germany are in range with results from randomised controlled studies.
The Effect of Food Vouchers and an Educational Intervention on Promoting Healthy Eating in Vulnerable Families: A Pilot Study
Authors: Miguel-Berges María L. , Jimeno-Martínez Andrea , Larruy-García Alicia , Moreno Luis A. , Rodríguez Gerardo , Iguacel Isabel
Published: March 2024

Cost has been reported as the main barrier to healthy eating in vulnerable groups. We aimed to evaluate the effect of a nutrition education intervention on adherence to Mediterranean Diet and health when providing food vouchers. This pilot study has a randomized control trial design. We included 66 vulnerable users from the Red Cross of Zaragoza (Spain). Intervention and control group individuals received 120 euros/month of food vouchers over 3 months to be spent in supermarkets (60 euros/month if under 12 y) plus a 10-week nutrition education program for the intervention group. Family food purchases were assessed using electronically recorded supermarket-obtained transactions. During and at the end of the intervention the percentage of healthy food was higher in the intervention than in the control group. Once the nutrition education was over, differences between groups dissipated. In the intervention group, health parameters improved, particularly weight-status, lipids, and liver enzymes. Control participants gained weight, although lipid and liver enzymes improved. Blood pressure and HbA1c did not improve in either the intervention or the control group. In conclusion, providing unrestricted food vouchers to vulnerable groups to increase healthy food consumption appears to be insufficient and should be accompanied by medium-long term nutrition education.
Cytogenetic monitoring as a method of integrated assessment of urbanized
territories of Rivne city, analysis of the state of the problem
Authors: Mialiuk Oksana P. , Kaskiv Maryana V.
Published: March 2024

Summary. Among the cities of Ukraine, in terms of population and
parametric characteristics of man-made impact on urban ecosystems, the city
of Rivne stands out. Excesses of various mutagens are regularly recorded in
its atmospheric air. In view of this, there is a need to control the
processes of air pollution in the city, study the nature of mutagenic
substances, prevent the growth of man-made pollution, and find means and
methods to protect living organisms from mutagenic effects. The aim of the
study – to conduct a bioindication of the urban ecosystem of Rivne on the
indicators of cytogenetic monitoring. Materials and Methods. To assess the
environmental situation against the general mutagenic background, we used a
rapid screening method – micronucleus test (MN test). To detect cells with
micronuclei, smears were taken from the oral mucosa of 167 preschool
children (6–7 years old) living on 12 test sites. Sampling was performed
under sterile conditions, from the right, left cheek and lower lip. Analysis
of the prepared cells was performed using a microscope. 64950 epithelial
cells of the mucous membrane were studied. Results. According to ecological
maps, the territory of the city, which is within III, IV, IX, X, and XII
test sites, has a "low" level of genetic damage, which determines the
"reference" ecological situation on a mutagenic background. Such
characteristics allow us to assess the state of the urban ecosystem in this
area of ​​the city as "favorable". However, the analysis of the situation on
some test sites allows us to note that the northeastern (III and IV test
sites) and the south-eastern (XII test site) parts of the city have slightly
higher rates of genetic damage compared to the south-western (IX and X test
sites) part. The rest of the test sites have a "below average" level of
genetic damage, which causes a "satisfactory" environmental situation with a
mutagenic background and an "alarming" state of the urban ecosystem. At the
same time, the highest values ​​of the MN test of epitheliocytes of
preschool children are characteristic of the north-western (I test site) and
south-eastern. The obtained dependence and high coefficient of determination
(0.35) indicate a significant relationship between the MN index and pollen
sterility of indicator plants, which were performed on similar 12 test
sites. Nevertheless, it should be noted that the vulnerability of pollen
grains of bioindicator plants was significantly higher (in terms of damage)
compared to the MN index, which is explained by the higher resistance to
environmental factors of children compared to pollen grains of indicator
plants. Conclusions. Analysis of research results indicates that the urban
ecosystem of Rivne is at a level "below ave­rage" of genetic damage,
"alarming" in the state of the biosystem, and "satisfactory" in the
mutagenic background
Poder, persuasão, exibição: análise de mensagens de “influenciadoras” na rede social Instagram
Authors: Seara Isabel Roboredo
Published: March 2024

The social media platform Instagram appears, currently, as a privileged communication space, where users can easily share and publish their photos and videos. We are therefore witnessing the emergence of female influencers, women who gain visibility through publications on this social network and who promote brands through images and comments on the products they advertise. Given Instagram’s highly competitive market, this study analyses posts on a Portuguese influencer’s page in order to reconsider, on one hand, the linguistic-discursive strategies of comments that convey the ethos of character and credibility and, on the other hand, the strategies at the service of the construction of power and persuasion. The analysis shows that the technique of glamourisation is used to create an excessive effect regarding what is being advertised in order to exert power.
O contributo dos estudos discursivos na construção de mensagens publicitárias nos meios digitais: análise da comunicação de uma marca de água de mesa
Authors: Simões Elsa , Tuna Sandra
Published: March 2024

Advertising has found opportunities and challenges in the new digital media. In these ways of communicating, we recognize complexity, variety, increased immediacy, and new dialogisms. Institutions and brands became aware of the impact of these new media and the need for more efficient communication. Discourse studies are an instrument for analysing promotional messages in traditional and digital media, but also contribute to institutions and brands using these media in efficient and ethically responsible ways. Three approaches are revisited to assess its spectrum of analysis: looking at communication as (1) social interaction, revealing power relations, cultural processes, and discursive practices (critical discourse analysis); (2) understanding the rhetorical architecture of the textual fabric, which enables an argumentative, persuasive, and effective discourse (rhetoric and argumentation); (3) examine the contribution of pragmatic linguistics to the understanding of language in the interaction created in new media (principles of conversation and implicature).
Como os suportes revista, jornal e internet impactam a produção do gênero discursivo reportagem
Authors: Araujo Giulia Chiaradia Gramuglia
Published: March 2024

In ‘Speech Genres and Other Late Essays’ written between 1952 and 1953, Bakhtin defined discursive genres as stylistic, thematic, and compositional utterances that are relatively stable. However, this reflection was made in a pre-internet context, without considering the impacts that mediums such as paper, radio, television, or more recently, computers and mobile devices have on genres. According to Bertocchi, genres cannot be defined solely by their prototypical structure and theme since the medium can also generate new types of utterances. Supporting this line of reasoning, this article identified that, in journalism, the medium can interfere with the discursive genre used. Thus, the differences between website reportage (cyber-reportage), newspaper reportage, and magazine reportage were systematized. The reflections made here were based on the Bakhtin Circle and an unpublished interview with journalist Fernando de Barros, former editor of Folha de S. Paulo and former director of Piauí magazine.
Proposições e leis sobre (in)segurança alimentar na perspectiva da Análise Textual dos Discursos
Authors: Pinheiro Cláudia Cynara Costa de Souza , Rodrigues Maria das Graças Soares
Published: March 2024

Propomo-nos a investigar o plano de texto, a enunciação e a argumentação em projetos de lei e em suas respectivas leis ordinárias que tratam da (in)segurança alimentar. Em termos teóricos, apoiamo-nos na Linguística Textual, na Linguística da Enunciação e na Análise Textual dos Discursos. Nosso estudo segue a abordagem qualitativa de natureza interpretativista, acompanha o método indutivo e é do tipo documental. Nossas hipóteses de uma materialidade textual prototípica, enunciativa e argumentativa se confirmaram ao atestar planos de texto fixos, organizados por sequências textuais, com marcas linguísticas da enunciação que seguem uma orientação argumentativa. Desse modo, os resultados apontam que a estrutura composicional é guiada por argumentos e propósitos comunicativos, ademais, as manifestações da responsabilidade enunciativa revelam distanciamento ou aproximação do conteúdo proposicional, bem como conferem autoria por meio das assinaturas finais nos projetos e nas leis. Portanto, nossas contribuições elucidam textos político-jurídicos importantes para o bem-estar social.
O funcionamento pré-discursivo e as estratégias textuais
Authors: Cavalcante Mônica Magalhães , Brito Mariza Angélica Paiva , Martins Mayara Arruda
Published: March 2024

In this work, we aim to show how a textual analysis deals with discursive "anteriorities". Pre-discourse refers to ideas, beliefs and narratives that circulate in a society or social group and that influence the production and interpretation of discursive uses (Paveau, 2013 [2006]). These pre-discourses must be considered in the linguistic analysis of the text since they affect individual perspectives and positions in relation to different issues. We analyzed two humorous cartoons to understand the dynamics of social and cultural influences that permeate textual production and interpretation. By taking pre-discourses into account in textual analysis, we admit that meaning is not only a result of the internal characteristics of the text but is also influenced by the broader context in which the text occurs. We justify why the analytical criteria of textual linguistics, such as, text plan, intertextuality and referencing, consider argumentative strategies assuming the distributed cognition.