bluuebunny/crossref_metadata_2025 huggingface dataset:
Disparity between Toarcian Oceanic Anoxic Event and Toarcian carbon isotope excursion
Authors: Ruebsam Wolfgang , Schwark Lorenz
Published: May 2024

The Toarcian Oceanic Anoxic Event (T-OAE, Early Jurassic) is marked by widespread marine deoxygenation and deposition of organic carbon (OC)-rich strata. The genesis of the T-OAE is thought to be associated with environmental changes caused by the emission of 12C-enriched greenhouse gasses (CO2, CH4), manifested in a negative Toarcian carbon isotope excursion (nT-CIE). The nT-CIE is commonly used to stratigraphically define the T-OAE, and despite the complex interrelationship of the different environmental phenomena, both terms (nT-CIE and T-OAE) are commonly used interchangeable. We here demonstrate that occurrence of OC-rich strata is diachronous and not restricted to the nT-CIE, reflecting the interaction of global- and regional-scale processes. Thus, the interchangeable use of T-OAE and nT-CIE should be discarded. The nT-CIE, however, hosts the T-OAE climax, marked by the widest extent of OC-rich strata. Early Toarcian environmental changes, particularly sea level rise and rising temperatures, may have made marine areas more susceptible to develop oxygen deficient conditions, favoring OC-accumulation.

Graphical abstract
Reservoir quality of Upper Cretaceous limestones (Ahlen-Fm., Beckum Member, Münsterland Cretaceous Basin): effects of cementation and compaction on the compactable depositional volume
Authors: Ölmez Jasemin Ayse , Busch Benjamin , Hilgers Christoph
Published: May 2024

The Upper Cretaceous limestones unconformably overlie Upper Carboniferous coal-bearing lithologies and are studied to assess their effect on rising mine-water levels in the Ruhr mining district. Upper Cretaceous sedimentary rocks from the Münsterland Cretaceous Basin have previously been studied regarding their sedimentary structures and fossil content. However, understanding the petrophysical and petrographic heterogeneity in regard to sedimentary properties and their effect on fluid migration pathways is yet missing. Utilizing He-pycnometry, Klinkenberg-corrected air permeabilities, p-wave velocities, transmitted and reflected light analyses, point-counting and cathodoluminescence, we assess the petrophysical, geomechanical and mineralogical properties. Porosity ranges from 1.0 to 18.7% and permeability ranges from < 0.0001 to 0.2 mD, while p-wave velocity ranges between 2089 and 5843 m/s. Mechanical compaction leads to grain rearrangement, deformation of calcispheres, foraminifera and ductile clay mineral laminae. Above and below clay laminae, compaction bands of deformed calcispheres develop. Early diagenetic mineral precipitation of ferroan calcite in inter- and intragranular pores reduces porosity and permeability and influences geomechanical properties. An underestimated aspect of limestone petrography is the relationship of the original primary compactable depositional volume and the influence of compaction, deformation and cementation during early and late diagenesis on reservoir properties. The detrital dominated limestones show an originally high compactable depositional volume (CDV). Overall, reservoir qualities are poor and indicate the sealing potential of the studied lithologies. The Upper Cretaceous (Campanian) limestones thus may act as a barrier for increasing mine-water levels from dismantled, post-mining subsurface hard coal mines in the region.

Graphical abstract
On growth and scoliosis
Authors: Smit Theodoor H.
Published: May 2024

Purpose

To describe the physiology of spinal growth in patients with adolescent idiopathic scoliosis (AIS).

Methods

Narrative review of the literature with a focus on mechanisms of growth.

Results

In his landmark publication On Growth and Form, D’Arcy Thompson wrote that the anatomy of an organism reflects the forces it is subjected to. This means that mechanical forces underlie the shape of tissues, organs and organisms, whether healthy or diseased. AIS is called idiopathic because the underlying cause of the deformation is unknown, although many factors are  associated. Eventually, however, any deformity is due to mechanical forces. It has long been shown that the typical curvature and rotation of the scoliotic spine could result from vertebrae and intervertebral discs growing faster than the ligaments attached to them. This raises the question why in AIS the ligaments do not keep up with the speed of spinal growth. The spine of an AIS patient deviates from healthy spines in various ways. Growth is later but faster, resulting in higher vertebrae and intervertebral discs. Vertebral bone density is lower, which suggests  less spinal compression. This also preserves the notochordal cells and the swelling pressure in the nucleus pulposus. Less spinal compression is due to limited muscular activity, and low muscle mass indeed underlies the lower body mass index (BMI) in AIS patients. Thus, AIS spines grow faster because there is less spinal compression that counteracts the force of growth (Hueter–Volkmann Law). Ligaments consist of collagen fibres that grow by tension, fibrillar sliding and the remodelling of cross-links. Growth and remodelling are enhanced by dynamic loading and by hormones like estrogen. However, they are opposed by static loading.

Conclusion

Increased spinal elongation and reduced ligamental growth result in differential strain and a vicious circle of scoliotic deformation. Recognising the physical and biological cues that contribute to differential growth  allows earlier diagnosis of AIS and prevention in children at risk.
Quantitative Analysis and 3D Visualization of Crack Behavior in 3D-Printed Rock-Like Specimens with Single Flaw Using In-Situ Micro-CT Imaging
Authors: Shao Yulong , Yang Jingwei , Kim Jineon , Mehrishal Seyedahmad , Song Jae-Joon
Published: May 2024

3D printing technology allows for precise control of preparing complex geometries and internal defects in printed rock analogs, while in-situ Micro-CT imaging enables real-time observation of crack behavior. The combination of these technologies offers a new research approach for studying rock crack behavior. In this study, 3D-printed rock-like specimens containing a pre-existing flaw were prepared using a gypsum powder-based 3D printer. An advanced in-situ Micro-CT system equipped with a loading device was used to quantitatively and visually investigate the crack behavior in 3D-printed specimens under uniaxial compression testing. 2D CT images obtained from in-situ compression testing at different deformations could be used to reconstruct a 3D model and visually identify the crack patterns of the extracted cracks in 3D-printed specimens. The initiation angle of cracks, volume of the pre-existing flaw, volume of newly formed cracks, and damage value with respect to strains were analyzed to quantitatively investigate crack behavior. The results indicated that within the 3D-printed specimens, tensile cracks were first initiated near the internal flaw, followed by the occurrence of shear cracks or tensile-shear mixed cracks at the flaw tips. Additionally, there was a negative linear correlation between the initiation angle of newly formed cracks and the initial flaw angle. For flaw angles in the range of 0° ≤ α ≤ 45°, a higher number of newly formed cracks were observed in the 3D-printed specimens, and the rates of increase in crack volume and damage values with strain were faster. However, for flaw angles in the range of 45° < α ≤ 90°, the results showed the opposite trend. Furthermore, through comparison with the crack behavior of natural rocks containing a single flaw, it was found that the failure modes and crack behavior of the 3D-printed specimens exhibit certain similarities with natural rocks.
Exploring the impact of chaos engineering with various user loads on cloud native applications: an exploratory empirical study
Authors: Al-Said Ahmad Amro , Al-Qora’n Lamis F. , Zayed Ahmad
Published: May 2024

One of the most popular models that provide computer resources today is cloud computing. Today’s dynamic and successful platforms are created to take advantage of various resources available from service providers. Ensuring the performance and availability of such resources and services is a crucial problem. Any software system may be subject to faults that might propagate to cause failures. Such faults with the potential of contributing to failures are critical because they impair performance and result in a delayed reaction, which is regarded as a dependability problem. To ensure that critical faults can be discovered as soon as possible, the impact of such faults on the system must be tested. The performance and dependability of cloud-native systems are examined in this empirical study using fault injection, one of the chaos engineering techniques. The study explores the impacts and results of injecting various delay times into two cloud-native applications with diverse user numbers. The performance of the applications with various numbers of users is measured in relation to these delays, which accordingly reflects measuring the dependability of those systems. Firstly, the systems’ architecture were identified, and serverless with two Lambda functions and containerised microservices applications were chosen, which depend on utilising and incorporating cloud-native services. Secondly, faults are injected in order to quantify performance attributes such as throughput and latency. The results of several controlled experiments carried out in real-world cloud environments provide exploratory empirical data, which promoted comparisons and statistical analysis that we utilised to identify the behaviour of the application while experiencing stress. Typical results from this investigation include an overall reduction in performance that is embodied in an increase in latency with injecting delays. However, a remarkable result is noticed at a particular delay in which defects and availability problems appear out of nowhere. These findings assist in highlighting the value of using chaos engineering in general and fault injection in particular to assess the dependability of cloud-native applications and to find unpredicted failures that could arise quickly from defects that aren’t supposed to spread and result in dependability issues.
A cyber defense system against phishing attacks with deep learning game theory and LSTM-CNN with African vulture optimization algorithm (AVOA)
Authors: Elberri Mustafa Ahmed , Tokeşer Ümit , Rahebi Javad , Lopez-Guede Jose Manuel
Published: May 2024

Phishing attacks pose a significant threat to online security, utilizing fake websites to steal sensitive user information. Deep learning techniques, particularly convolutional neural networks (CNNs), have emerged as promising tools for detecting phishing attacks. However, traditional CNN-based image classification methods face limitations in effectively identifying fake pages. To address this challenge, we propose an image-based coding approach for detecting phishing attacks using a CNN-LSTM hybrid model. This approach combines SMOTE, an enhanced GAN based on the Autoencoder network, and swarm intelligence algorithms to balance the dataset, select informative features, and generate grayscale images. Experiments on three benchmark datasets demonstrate that the proposed method achieves superior accuracy, precision, and sensitivity compared to other techniques, effectively identifying phishing attacks and enhancing online security.
Evaluating the merits and constraints of cryptography-steganography fusion: a systematic analysis
Authors: Haverkamp Indy , Sarmah Dipti K.
Published: May 2024

In today's interconnected world, safeguarding digital data's confidentiality and security is crucial. Cryptography and steganography are two primary methods used for information security. While these methods have diverse applications, there is ongoing exploration into the potential benefits of merging them. This review focuses on journal articles from 2010 onwards and conference papers from 2018 onwards that integrate steganography and cryptography in practical applications. The results are gathered through different databases like Scopus, IEEE, and Web of Science. Our approach involves gaining insights into real-world applications explored in the existing literature and categorizing them based on domains and technological areas. Furthermore, we comprehensively analyze the advantages and limitations associated with these implementations, examining them from three evaluation perspectives: security, performance, and user experience. This categorization offers guidance for future research in unexplored areas, while the evaluation perspectives provide essential considerations for analyzing real-world implementations.
Treatment patterns and clinical outcomes in patients with metastatic triple-negative breast cancer: a large-scale data analysis using the Japanese claims database
Authors: Kimura Takayuki , Takami Tomoko , Piao Yi , Ntalla Ioanna , Saji Shigehira
Published: May 2024

Purpose

This study evaluated treatment patterns and clinical outcomes among patients with metastatic triple-negative breast cancer (mTNBC) in real-world clinical settings in Japan.

Methods

The treatment patterns, time to next treatment or death (TTNTD), time to treatment discontinuation, adverse events of interest, and medical costs of treating patients with mTNBC in first-, second-, and third-line settings were investigated using data of patients meeting the inclusion criteria between January 2017 and March 2022 in a Japanese medical claims database. The treatment regimens for mTNBC were defined according to the Japanese Breast Cancer Society Clinical Practice Guidelines.

Results

In this study, 2236 patients with mTNBC (median age 66.0 years; 99.8% female) were included in the first-line cohort. Of these, 46.6% and 20.8% were included in the second- and third-line cohorts, respectively. The two most frequently used treatments were capecitabine (19.1%) and S-1 (tegafur–gimeracil–oteracil) (14.5%) in the first-line cohort, eribulin (18.3%) and bevacizumab/paclitaxel (14.4%) in the second-line cohort, and eribulin (19.4%) and bevacizumab/paclitaxel (17.5%) in the third-line cohort. The TTNTD shortened as the line of therapy progressed (median 8.0, 6.5, and 5.2 months for the first-, second-, and third-line treatments, respectively). Nausea/vomiting and neutropenia/leukopenia occurred in 62.8% and 18.3% of all patients, respectively. The medical total costs per day were 6.7, 10.2, and 12.9 thousand yen during the first-/second-/third-line treatments, respectively.

Conclusion

This study provides insight into current treatment patterns for mTNBC in Japan. The cost–benefit balance worsens with later-line treatment and a high unmet need for mTNBC drug treatment remains.
Novel hybrid classifier based on fuzzy type-III decision maker and ensemble deep learning model and improved chaos game optimization
Authors: Mehrabi Hashjin Nastaran , Amiri Mohammad Hussein , Mohammadzadeh Ardashir , Mirjalili Seyedali , Khodadadi Nima
Published: May 2024

This paper presents a unique hybrid classifier that combines deep neural networks with a type-III fuzzy system for decision-making. The ensemble incorporates ResNet-18, Efficient Capsule neural network, ResNet-50, the Histogram of Oriented Gradients (HOG) for feature extraction, neighborhood component analysis (NCA) for feature selection, and Support Vector Machine (SVM) for classification. The innovative inputs fed into the type-III fuzzy system come from the outputs of the mentioned neural networks. The system’s rule parameters are fine-tuned using the Improved Chaos Game Optimization algorithm (ICGO). The conventional CGO’s simple random mutation is substituted with wavelet mutation to enhance the CGO algorithm while preserving non-parametricity and computational complexity. The ICGO was evaluated using 126 benchmark functions and 5 engineering problems, comparing its performance with well-known algorithms. It achieved the best results across all functions except for 2 benchmark functions. The introduced classifier is applied to seven malware datasets and consistently outperforms notable networks like AlexNet, ResNet-18, GoogleNet, and Efficient Capsule neural network in 35 separate runs, achieving over 96% accuracy. Additionally, the classifier’s performance is tested on the MNIST and Fashion-MNIST in 10 separate runs. The results show that the new classifier excels in accuracy, precision, sensitivity, specificity, and F1-score compared to other recent classifiers. Based on the statistical analysis, it has been concluded that the ICGO and propose method exhibit significant superiority compared to the examined algorithms and methods. The source code for ICGO is available publicly at https://nimakhodadadi.com/algorithms-%2B-codes.

Graphical abstract
A Non-Vacuist Response to the Counterpossible Terrible Commands Objection
Authors: Choo Frederick
Published: May 2024

Critics of Divine Command Theory (DCT) argue that DCT implies the following counterpossible is true: If God commanded us to perform a terrible act, then the terrible act would be morally obligatory. However, our intuitions tell us that such a counterpossible is false. Therefore, DCT fails. This is the counterpossible terrible commands objection. In this paper, I argue that the counterpossible terrible commands objection fails. I start by considering a standard response by DCT proponents that appeals to vacuism—the view that all counterpossibles are vacuously true. I argue that DCT proponents should pursue a different response instead. I then go on to provide a new response to the counterpossible terrible commands objection: I argue that we lack reason to think that the counterpossible in question is false by examining the underlying intuitions.
Does Panpsychism Explain Mental Causation?
Authors: Baysan Umut
Published: May 2024

In the contemporary literature on panpsychism, one often finds the claim that a Russellian-monist version of panpsychism, i.e., Russellian panpsychism, is a superior view compared to alternative non-physicalist theories. The argument for this claim is that while Russellian panpsychism can integrate consciousness in the causal order and explain mental causation, alternative theories fail to do so. If this is correct, panpsychism deserves its place as a main contender in solving the mind-body problem. In this paper, I argue that Russellian panpsychism’s superiority in explaining mental causation over competing accounts is illusory. On one reading, the proposed explanation is not an explanation of the phenomenon that is at stake in the mental causation debate. On an alternative reading, it is an explanation of the right phenomenon, but analogous explanations are available to competing accounts with less counterintuitive commitments. While there may be other considerations supporting panpsychism, explaining mental causation is not one.
Ocular complications in adults with psoriasis: a cross-sectional study in a referral center in Brazil
Authors: Oliveira Ricardo Danilo Chagas , Faneli Adriano Cypriano , Amaral Dillan Cunha , Chagas Julia Motta , Guedes Jaime , Follador Ivonise , de Oliveira Maria de Fatima Santos Paim , Fernandes Bruno F. , Correia Luis Claudio Lemos
Published: May 2024

Purpose

There is limited literature on the ocular manifestations in patients with psoriasis. Therefore, this study aimed to identify the prevalence of and factors associated with ocular manifestations in adults with psoriasis.

Methods

This cross-sectional study included Brazilian adults with psoriasis. The dermatological evaluation included diagnosis, clinical form, Psoriasis Area and Severity Index (PASI) measurement, and location of the lesions. Patients underwent a full ophthalmological examination, including the Schirmer I test, Rose Bengala staining, and tear breakup time tests. The results were analyzed using chi-square and Pearson’s linear correlation tests.

Results

Of the 130 patients assessed, 118 (90.8%) exhibited ocular abnormalities, with meibomian gland dysfunction (MGD) being the most prevalent (59.2%), followed by dry eye disease (DED) (56.2%). A significant correlation was observed between MGD and PASI (p = 0.05), and between MGD and certain treatment modalities. DED was significantly associated with PASI (p < 0.05). Concurrent use of acitretin was identified as an independent predictor of MGD (odds ratio [OR] = 3.5, p < 0.05), whereas PASI was a protective factor against DED (OR = 0.39, p < 0.01).

Conclusion

Given the high prevalence of eye disease among individuals with psoriasis, routine ophthalmological assessments are recommended to prevent possible ocular complications.
The spatial dimensions of cultural consumption: how distance influences consumption levels in a spatial setting
Authors: Biferale Lorenzo , Brandano Maria Giovanna , Crociata Alessandro , Melo Hygor P. M.
Published: May 2024

Cultural consumption has increasingly acquired a fundamental role in urban policy frameworks, thanks to its empirically proven positive effects on individuals and on societies. Although several theoretical and empirical contributions have examined the main socio-economic determinants that explain cultural consumption; its spatial dimensions remain significantly under-considered and require further analysis. The aim of this paper is to analyse the factors influencing cultural consumption with a focus on spatial distance and spatial dependence. Specifically, it seeks to inquire into the extent to which spatial distance between consumers and cultural institutions plays a role in neighbourhood’s levels of cultural consumption. To do this, human mobility data towards cultural institutions are used as a proxy for individual cultural consumption levels in six French cities. Results show that spatial proximity with the cultural offer matters in explaining consumption patterns, but that traditional socioeconomic determinants have a higher explanatory value.
Proper colorability of segment intersection graphs
Authors: Barish Robert D. , Shibuya Tetsuo
Published: May 2024

We consider the vertex proper coloring problem for highly restricted instances of geometric intersection graphs of line segments embedded in the plane. Provided a graph in the class UNIT-PURE-k-DIR, corresponding to intersection graphs of unit length segments lying in at most k directions with all parallel segments disjoint, and provided explicit coordinates for segments whose intersections induce the graph, we show for $$k = 4$$

k
=
4

that it is NP-complete to decide if a proper 3-coloring exists, and moreover, $$\#P$$

#
P

-complete under many-one counting reductions to determine the number of such colorings. In addition, under the more relaxed constraint that segments have at most two distinct lengths, we show these same hardness results hold for finding and counting proper $$\left( k-1\right) $$

k
-
1

-colorings for every $$k \ge 5$$

k
≥
5

. More generally, we establish that the problem of proper 3-coloring an arbitrary graph with m edges can be reduced in $${\mathcal {O}}\left( m^2\right) $$

O

m
2

time to the problem of proper 3-coloring a UNIT-PURE-4-DIR graph. This can then be shown to imply that no $$2^{o\left( \sqrt{n}\right) }$$

2

o

n

time algorithm can exist for proper 3-coloring PURE-4-DIR graphs under the Exponential Time Hypothesis (ETH), and by a slightly more elaborate construction, that no $$2^{o\left( \sqrt{n}\right) }$$

2

o

n

time algorithm can exist for counting the such colorings under the Counting Exponential Time Hypothesis (#ETH). Finally, we prove an NP-hardness result for the optimization problem of finding a maximum order proper 3-colorable induced subgraph of a UNIT-PURE-4-DIR graph.
A Systematic Review of Trajectories of Clinically Relevant Distress Amongst Adults with Cancer: Course and Predictors
Authors: Curran Leah , Mahoney Alison , Hastings Bradley
Published: May 2024

To improve interventions for people with cancer who experience clinically relevant distress, it is important to understand how distress evolves over time and why. This review synthesizes the literature on trajectories of distress in adult patients with cancer. Databases were searched for longitudinal studies using a validated clinical tool to group patients into distress trajectories. Twelve studies were identified reporting trajectories of depression, anxiety, adjustment disorder or post-traumatic stress disorder. Heterogeneity between studies was high, including the timing of baseline assessments and follow-up intervals. Up to 1 in 5 people experienced persistent depression or anxiety. Eight studies examined predictors of trajectories; the most consistent predictor was physical symptoms or functioning. Due to study methodology and heterogeneity, limited conclusions could be drawn about why distress is maintained or emerges for some patients. Future research should use valid clinical measures and assess theoretically driven predictors amendable to interventions.
Characterization of Corrosion-Induced Fracture in Reinforced Concrete Beams Using Electrical Potential, Ultrasound and Low-Frequency Vibration
Authors: Ferenc Tomasz , Wojtczak Erwin , Meronk Błażej , Ryl Jacek , Wilde Krzysztof , Rucka Magdalena
Published: May 2024

The paper deals with the non-destructive experimental testing of the reinforced concrete beams under progressive corrosion. A series of experiments using electrical potential, ultrasound and low-frequency vibrations techniques are reported. Electrical potential and natural frequencies were used to characterise and monitor the corrosion process at its initial state. The P-wave velocity measurements were proved to be effective in quantitative assessment of the level of corrosion as it progresses. The possibility of early detection of damage using a proposed damage index and diagnostic framework is promising for possible applications in the non-invasive diagnostics of reinforced concrete elements.
Bill 7633 on the restriction of the use of Russian text sources in Ukrainian research and education: analysing language policy in times of war
Authors: Lunyova Tetyana , Lanvers Ursula , Zelik Oksana
Published: May 2024

For centuries, Ukraine has been a site of conflicts over language rights. During 70 years of Soviet leadership, Ukraine experienced’relentless Russification’ (Reznik in Language of conflict: discourses of the Ukrainian crisis (pp. 169–191). Bloomsbury Publishing, London, 2020 p. 170). After breaking from Soviet rule, the Ukrainian language became an increasingly powerful symbol and means of national identity. Since the full-scale Russian invasion of Ukraine in 2022, the language issues have gained yet more public and political attention. Addressing the urgency, the Ukrainian parliament adopted, in the first reading, Bill 7633, aiming to restrict the use of any Russian sources in Ukrainian school and academia, a bill that was met with criticism and experienced intensified debates. This article analyses a range of text sources (both governmental and non-governmental) debating Bill 7633, using Discourse Analysis, and reveals how ‘liberal values’ and ‘lived liberalism’ (Fedirko et al. in Social Anthropol/Anthropol soc 29(2):373–386, 2021) are practiced or violated through problematising or justifying the Bill. Thus, the article contributes to the (recently emerged, i.e. since the start of Russian annexation of the Crimea in 2014) body of research on political and public discourses of the Ukrainian conflict (Epstein in Studies in East Eur Thought 74(4), 475–481; Jones, 2020; Lanvers and Lunyova in Eur J Lang Policy 15(1), 25–68; Slobozhan et al. in Soc Netw Anal Min 12(1), 1–12, 2022). Results show a comprehensive range of arguments both for and against Bill 7633 in both governmental and non-governmental texts which is interpreted as a form of liberalism in fragments (Fedirko in Social Anthropol/Anthropol Soc, 29(2), 471–489, 2021). The conclusion debates the unreserved applicability of western conceptualisation of liberal language policy in the context of war and prolonged linguistic contestations.
Ancestry of the major long-range regulatory site of the α-globin genes in the Portuguese population with the common 3.7 kb α-thalassemia deletion
Authors: Pena Rita , Lopes Pedro , Gaspar Gisela , Miranda Armandina , Faustino Paula
Published: May 2024

Background

The α-Major Regulatory Element (α-MRE), also known as HS-40, is located upstream of the α-globin gene cluster and has a crucial role in the long-range regulation of the α-globin gene expression. This enhancer is polymorphic and several haplotypes were identified in different populations, with haplotype D almost exclusively found in African populations. The purpose of this research was to identify the HS-40 haplotype associated with the 3.7 kb α-thalassemia deletion (-α3.7del) in the Portuguese population, and determine its ancestry and influence on patients’ hematological phenotype.

Methods and results

We selected 111 Portuguese individuals previously analyzed by Gap-PCR to detect the presence of the -α3.7del: 50 without the -α3.7del, 34 heterozygous and 27 homozygous for the -α3.7del. The HS-40 region was amplified by PCR followed by Sanger sequencing. Four HS-40 haplotypes were found (A to D). The distribution of HS-40 haplotypes and genotypes are significantly different between individuals with and without the -α3.7del, being haplotype D and genotype AD the most prevalent in patients with this deletion in homozygosity. Furthermore, multiple correspondence analysis revealed that individuals without the -α3.7del are grouped with other European populations, while samples with the -α3.7del are separated from these and found more closely related to the African population.

Conclusion

This study revealed for the first time an association of the HS-40 haplotype D with the -α3.7del in the Portuguese population, and its likely African ancestry. These results may have clinical importance as in vitro analysis of haplotype D showed a decrease in its enhancer activity on α-globin gene.
Linagliptin ameliorates tacrolimus-induced renal injury: role of Nrf2/HO-1 and HIF-1α/CTGF/PAI-1
Authors: Nady Mohamed E. , El-Raouf Ola M. Abd , El-Sayed El-Sayed M.
Published: May 2024

Background

Tacrolimus (TAC) is a frequently used immunosuppressive medication in organ transplantation. However, its nephrotoxic impact limits its long-term usage. This study aims to investigate the effect of linagliptin (Lina) on TAC-induced renal injury and its underlying mechanisms.

Methods and results

Thirty-two Sprague Dawley rats were treated with TAC (1.5 mg/kg/day, subcutaneously) and/or Lina (5 mg/kg/day, orally) for 4 weeks. Histological examination was conducted, and serum and urinary biomarkers were measured to assess kidney function and integrity. Furthermore, ELISA, Western blot analysis and immunohistochemical assay were employed to determine signaling molecules of oxidative stress, profibrogenic, hypoxic, and apoptotic proteins. Tacrolimus caused renal dysfunction and histological deterioration evidenced by increased serum creatinine, blood urea nitrogen (BUN), urinary cystatin C, and decreased serum albumin as well as elevated tubular injury and interstitial fibrosis scores. Additionally, TAC significantly increased the expression of collagen type-1, alpha-smooth muscle actin (α-SMA), plasminogen activator inhibitor-1 (PAI-1), and transforming growth factor-beta1 (TGF-β1) renal content. Moreover, TAC decreased the expression of nuclear factor erythroid-2-related factor2 (Nrf2), heme oxygenase 1 (HO-1), and mitochondrial superoxide dismutase (SOD2). In addition, TAC increased protein expression of hypoxia-inducible factor1-alpha (HIF-1α), connective tissue growth factor (CTGF), inducible nitric oxide synthase (iNOS), 8-hydroxy-2-deoxyguanosine (8-OHdG), as well as nitric oxide (NO), 4-hydroxynonenal, caspase-3 and Bax renal contents. Furthermore, TAC decreased Bcl-2 renal contents. The Lina administration markedly attenuated these alterations.

Conclusion

Lina ameliorated TAC-induced kidney injury through modulation of oxidative stress, hypoxia, and apoptosis related proteins.
Rapid Diagnosis of Pneumocystis jirovecii Pneumonia and Respiratory Tract Colonization by Next-Generation Sequencing
Authors: Xing Fanfan , Deng Chaowen , Luo Zhendong , Zou Shan , Liu Min , Ye Haiyan , Sun Linlin , Tsang Chi-Ching , Lo Simon K. F. , Lau Susanna K. P. , Woo Patrick C. Y.
Published: May 2024

Objectives

To describe the epidemiology of Pneumocystis jirovecii pneumonia and colonization diagnosed by next-generation sequencing (NGS) and explore the usefulness of the number of P. jirovecii sequence reads for the diagnosis of P. jirovecii pneumonia.

Methods

We examined the NGS results for P. jirovecii in respiratory samples collected from patients and analysed their clinical, radiological and microbiological characteristics.

Results

Among 285 respiratory samples collected over a 12-month period (January to December 2022), P. jirovecii sequences were detected in 56 samples from 53 patients. Fifty (94.3%) of the 53 patients were HIV-negative. Following our case definitions, 37 (69.8%) and 16 (30.2%) of the 53 patients had P. jirovecii infection and colonization respectively. P. jirovecii infection was associated with presence of underlying disease with immunosuppression (94.6% vs 18.8%, P < 0.05), positive serum 1,3-β-D-glucan (41.2% vs 0%, P < 0.01) and higher number of P. jirovecii sequence reads (P < 0.005). In contrast, P. jirovecii colonization was associated with the male sex (93.8% vs 54.1%, P < 0.01), another definitive infectious disease diagnosis of the respiratory tract (43.8% vs 2.7%, P < 0.001) and higher survival (100% vs 67.6%, P < 0.01). Although P. jirovecii pneumonia was associated with higher number of P. jirovecii reads in respiratory samples, only a sensitivity of 82.14% and a specificity of 68.75% could be achieved.

Conclusion

Detection of P. jirovecii sequences in respiratory samples has to be interpreted discreetly. A combination of clinical, radiological and laboratory findings is still the most crucial in determining whether a particular case is genuine P. jirovecii pneumonia.
Exploring European Consensus About the Remaining Treatment Challenges and Subsequent Opportunities to Improve the Management of Invasive Fungal Infection (IFI) in the Intensive Care Unit
Authors: Hoenigl Martin , Enoch David A. , Wichmann Dominic , Wyncoll Duncan , Cortegiani Andrea
Published: May 2024

Background

The global prevalence of invasive fungal infections (IFI) is increasing, particularly within Intensive Care Units (ICU), where Candida spp. and Aspergillus spp. represent the most important pathogens. Diagnosis and management of IFIs becomes progressively challenging, with increasing antifungal resistance and the emergence of rare fungal species.

Through a consensus survey focused on assessing current views on how IFI should be managed, the aim of this project was to identify challenges around diagnosing and managing IFIs in the ICU. The current status in different countries and perceived challenges to date amongst a multidisciplinary cohort of healthcare professionals involved in the care of IFI in the ICU was assessed.

Methods

Using a modified Delphi approach, an expert panel developed 44 Likert-scale statements across 6 key domains concerning patient screening and minimal standards for diagnosis of IFIs in ICU; initiation and termination of antifungal treatments and how to minimise their side effects and insights for future research on this topic. These were used to develop an online survey which was distributed on a convenience sampling basis utilising the subscriber list held by an independent provider (M3 Global). This survey was distributed to intensivists, infectious disease specialists, microbiologists and antimicrobial/ICU pharmacists within the UK, Germany, Spain, France and Italy. The threshold for consensus was set at 75%.

Results

A total of 335 responses were received during the five-month collection period. From these, 29/44 (66%) statements attained very high agreement (90%), 11/44 (25%) high agreement (< 90% and ≥ 75%), and 4/44 (9%) did not meet threshold for consensus (< 75%).

Conclusion

The results outline the need for physicians to be aware of the local incidence of IFI and the associated rate of azole resistance in their ICUs. Where high clinical suspicion exists, treatment should start immediately and prior to receiving the results from any diagnostic test. Beta-D-glucan testing should be available to all ICU centres, with results available within 48 h to inform the cessation of empirical antifungal therapy. These consensus statements and proposed measures may guide future areas for further research to optimise the management of IFIs in the ICU.
Design and analysis of polarization-insensitive molybdenum-based ultra-wideband solar energy absorber with wide-incident-angle
Authors: Abouelez Ahmed Elsayed , Eldiwany Essam A.
Published: May 2024

We introduce an ultra-wideband absorber with a molybdenum and Al2O3 multilayer structure for solar energy harvesting. The proposed structure could maintain its structural integrity at high temperatures thanks to the refractory materials used in its construction. Under normal incidence of optical waves, absorption of more than 90% is achieved throughout a broad range of wavelengths from 300 nm to approximately 3177 nm with a bandwidth of 2877 nm which covers ultraviolet, visible, and near-infrared spectral bands. The average absorption in that band is calculated to be 96.46%. The proposed design’s symmetrical characteristic makes the absorber insensitive to the polarization of the incident optical wave. Furthermore, throughout a broad range of optical wave angles of incidence for both transverse electric and transverse magnetic polarizations, the absorber supports absorptivity greater than 80%.
The influence of patients’ beliefs about medicines and the relationship with suboptimal medicine use in community-dwelling older adults: a systematic review of quantitative studies
Authors: Rafhi Eman , Al-Juhaishi Malath , Stupans Ieva , Stevens Julie E. , Park Joon Soo , Wang Kate N.
Published: May 2024

Background

Medication use in older adults is increasing, therefore, reducing the risk of suboptimal medicine use is imperative in achieving optimal therapeutic outcomes. Research suggests that factors such as personal beliefs and beliefs about medicines may be associated with non-adherence and inappropriate medicine use.

Aim

To systematically review and identify quantitative research on the influence of beliefs about medicines and the relationship with suboptimal medicine use in older adults.

Method

Searches were conducted on PubMed, EMBASE, CINAHL, and PsycINFO for quantitative studies (inception to March 2023). Inclusion criteria: (1) exposure: participants’ beliefs (personal, cultural, and medication-related), (2) outcomes: polypharmacy, potentially inappropriate medicines use, or non-adherence, and (3) participants: community-dwelling adults 65 years or above. Study selection, data extraction and quality appraisal (Joanna Briggs Institute critical appraisal checklist) were completed independently by two investigators. Data were combined in a narrative synthesis and presented in a summary of findings table.

Results

Nineteen articles were included: 15 cross-sectional and four cohort studies. Outcomes of included papers were as follows; adherence (n = 18) and potentially inappropriate medicine use (n = 1). Ten studies found stronger beliefs in the necessity of medicines and/or fewer concerns led to better adherence, with one paper contradicting these findings. Three studies did not find associations between adherence and beliefs. One study confirmed an association between unnecessary drug use and a lack of belief in a "powerful other" (e.g. doctor).

Conclusion

Further investigation is necessary to (1) ascertain the importance of necessity or concern beliefs in fostering adherence and, (2) examine the influence of beliefs on polypharmacy and inappropriate medicine use.
Outcome Isn’t Everything: Electoral Consequences of Implementing or Withdrawing Unpopular Policies
Authors: Gren Simon , Leuschner Elena
Published: May 2024

Incumbents often make unpopular policy decisions. But can they remedy their negative electoral consequences? We extend the wide literature concerning retrospective voting to the case of unpopular policies and examine whether voters reward a responsive withdrawal of an unpopular policy proposal or punish the disclosed policy intention despite the withdrawal. To test this, we use granular data on Swedish local election results from 2002 to 2018 and the case of widely unpopular school closure proposals, some of which were implemented and others not. We exploit within municipality variation in voting over time to causally estimate the consequences for incumbents in the neighborhood surrounding the schools. Our results confirm that even if a school remains open, voters punish the incumbent and consider the initial proposal as informative for their vote. Our findings have implications for the understanding of democratic accountability and which information voters take into account when casting their vote.
Policy and Fertility, a Case Study of the Quebec Parental Insurance Plan
Authors: Laplante Benoît
Published: May 2024

In 2006, the Quebec government implemented a parental leave program more generous than the scheme available through the Canadian federal Employment Insurance (EI) program. It was aimed at maintaining the personal disposable income after a birth, especially for women whose income exceeds the maximum insurable earnings of EI. In this article, we assess whether the implementation of the Quebec Parental Insurance Plan (QPIP) was associated with an increase in the fertility in Quebec, especially for highly educated women. We use data from the rotating panels of the Canadian Labor Force Survey. We test the effect of the implementation of the QPIP on fertility by comparing Quebec and Ontario, which kept the federal EI scheme, before and after the implementation of the QPIP. We adapt the difference in differences method (DiD) to the modeling of the fertility schedule using Poisson regression. We estimate fertility by educational levels within each of the four groups of the DiD design by integrating the estimated fertility schedules. Our results show that the implementation of the QPIP was associated with an increase in fertility in Quebec. The magnitude of the increase varies by educational levels: 17% for women who did not complete secondary education, 46% for those who completed it, and 27% for women who earned a university diploma.
Complementary information concerning the suspected interindividual transmission of GW1516, a substance prohibited in sport, through intimate contact: a case report
Authors: Breuer J. , Garzinsky A. M. , Thomas A. , Nieschlag E. , Kliesch S. , Fedoruk M. , Geyer H. , Thevis M.
Published: May 2024

Purpose

Inadvertent and/or unknowing exposure to drugs and drug residues has been frequently debated in situations of so-called adverse analytical finding (AAF) in the context of sports drug testing programs. Transfer of drug residues via unprotected intercourse is a conceivable scenario but scientific data and authentic case reports are scarce. Herein, investigations into two AAFs with the peroxisome proliferator-activated receptor delta (PPARδ) agonist GW1516 are reported and discussed.

Methods

To probe for a contamination scenario involving sexual intercourse, two assays were used to determine semenogelin in human urine, with one employing an immunochromatographic lateral flow approach and another based on liquid chromatography–tandem mass spectrometry. Further, drug-residue testing using patients’ ejaculate was conducted by utilizing liquid chromatography in conjunction with a triple quadrupole mass spectrometer, followed by re-analysis of suspect samples (i.e., samples indicating the presence of relevant compounds) using high resolution/high mass accuracy mass spectrometry.

Results

In one case, but not the other, the possibility of intimate contact as the source of the AAF was confirmed after a thorough investigation of potential contamination scenarios. Subsequent research revealed analytical evidence for the presence of seminal fluid in one of the female athlete’s doping control urine samples, and the analysis of clinical ejaculate specimens provided first data on an authentic concentration level of GW1516 and its metabolites in human seminal fluid.

Conclusions

The combined facts substantiate the possibility of an AAF caused by unprotected sexual intercourse and the plausibility of the case-related arguments.
A theoretical framework for improved fire suppression by linking management models with smart early fire detection and suppression technologies
Authors: Meng Li , O’Hehir Jim , Gao Jing , Peters Stefan , Hay Anthony
Published: May 2024

Bushfires are devastating to forest managers, owners, residents, and the natural environment. Recent technological advances indicate a potential for faster response times in terms of detecting and suppressing fires. However, to date, all these technologies have been applied in isolation. This paper introduces the latest fire detection and suppression technologies from ground to space. An operations research method was used to assemble these technologies into a theoretical framework for fire detection and suppression. The framework harnesses the advantages of satellite-based, drone, sensor, and human reporting technologies as well as image processing and artificial intelligence machine learning. The study concludes that, if a system is designed to maximise the use of available technologies and carefully adopts them through complementary arrangements, a fire detection and resource suppression system can achieve the ultimate aim: to reduce the risk of fire hazards and the damage they may cause.
The creative–destructive force of hurricanes: evidence from technological adoption in colonial Jamaican sugar estates
Authors: Huesler Joel , Strobl Eric
Published: May 2024

While in the early part of the nineteenth-century Jamaica was one of the world’s leading sugar producers, the abolition of slavery, the flooding of sugar markets with cheap European beet sugar, and the equalization and finally elimination of sugar import duties across the British empire led to a need for more efficient ways to produce sugar. However, it has been widely noted that Jamaica sugar estates were late in adopting more efficient production techniques, arguably due to inadequate financing. This paper investigates what role the destructive forces of hurricanes may have played in inducing Jamaica to finally modernize its sugar production. To this end, we combine a geo-referenced exhaustive data set of Jamaican sugar estates with a measure of localized hurricane damage constructed from historical hurricane tracks over the period 1882 to 1930. Our econometric analysis shows that hurricane strikes increased the probability that a surviving estate upgraded its sugar processing technology, particularly when the price of sugar was high and the price of the other main exporting crop (bananas) was low. Additionally, while a government hurricane loan programme working through local loan banks did help plantations to adopt new machinery, this depended on the damage not being too large.