bluuebunny/crossref_metadata_2025 huggingface dataset:
Aflatoxin Contamination: An Overview on Health Issues, Detection and Management Strategies
Authors: Alameri Meera Mohamed , Kong Amanda Shen-Yee , Aljaafari Mariam Nasser , Ali Hajer Al , Eid Khadija , Sallagi Maryam Al , Cheng Wan-Hee , Abushelaibi Aisha , Lim Swee-Hua Erin , Loh Jiun-Yan , Lai Kok-Song
Published: March 2023

Aflatoxins (AFs) represent one of the main mycotoxins produced by Aspergillus flavus and Aspergillus parasiticus, with the most prevalent and lethal subtypes being AFB1, AFB2, AFG1, and AFG2. AFs are responsible for causing significant public health issues and economic concerns that affect consumers and farmers globally. Chronic exposure to AFs has been linked to liver cancer, oxidative stress, and fetal growth abnormalities among other health-related risks. Although there are various technologies, such as physical, chemical, and biological controls that have been employed to alleviate the toxic effects of AF, there is still no clearly elucidated universal method available to reduce AF levels in food and feed; the only mitigation is early detection of the toxin in the management of AF contamination. Numerous detection methods, including cultures, molecular techniques, immunochemical, electrochemical immunosensor, chromatographic, and spectroscopic means, are used to determine AF contamination in agricultural products. Recent research has shown that incorporating crops with higher resistance, such as sorghum, into animal feed can reduce the risk of AF contamination in milk and cheese. This review provides a current overview of the health-related risks of chronic dietary AF exposure, recent detection techniques, and management strategies to guide future researchers in developing better detection and management strategies for this toxin.
Constraining the Viscous Dark Energy Equation of State in f (R, Lm) Gravity
Authors: Jaybhaye Lakhan V. , Solanki Raja , Mandal Sanjay , Sahoo Pradyumn Kumar
Published: March 2023

In this article, we attempt to describe the cosmic late-time acceleration of the universe in the framework of f(R,Lm) gravity, by using an effective equation of state, when bulk viscosity is taken into account. We presume a non-linear f(R,Lm) functional form, specifically, f(R,Lm)=R2+Lmα, where α is a free model parameter. We obtain the exact solution of our bulk viscous matter dominated f(R,Lm) model, and then we utilize the combined H(z) + Pantheon + Analysis datasets to estimate the best fit values of the free parameters of our model. Then, we characterize the behavior of the matter–energy density, effective pressure, and the equation of state (EoS) parameter, incorporating the viscous type fluid. The evolution profile of the effective EoS parameter depicts an acceleration phase of the cosmic expansion, whereas the pressure, with the effect of viscosity, exhibits negative behavior, that can lead to the accelerating expansion of the universe. Moreover, the cosmic matter–energy density shows the expected positive behavior. Further, we investigate the behavior of the statefinder parameters for the assumed f(R,Lm) model. We find that the evolutionary trajectory of the given model lies in the quintessence region. In addition, we employ the Om diagnostic test, that indicates that our model exhibits quintessence behavior. Lastly, we check the energy condition criteria and find that the violation of SEC occurs in the past, whereas NEC and DEC satisfy the positivity criteria. We find that our f(R,Lm) cosmological model, with the effect of bulk viscosity, provides a good fit of the recent observational data and can efficiently describe the cosmic expansion scenario.
Defining the Organization of Municipal Solid Waste Management Based on Production Costs
Authors: Beccarello Massimo , Di Foggia Giacomo
Published: March 2023

A long-lasting dilemma on the efficient provision of services of general economic interest has become increasingly important in the waste management industry: competition or monopoly in municipal solid waste management. Previous literature has primarily examined the economics of scale and scope to provide an adequate response. Here, we contribute by investigating subadditivity in municipal solid waste management service costs. Subadditivity is a critical concept used to justify imperfect competition, which encourages natural monopolies where one producer will function more effectively than more firms. To test the hypothesis that a subadditivity in costs in waste management exists, we design a simulation based on empirical data for Milan, Italy. We compared the total production cost of the incumbent firm with the alternative hypothesis built by dividing the city into four areas and assigning each area to a different hypothetical firm. The results suggest that the existence of subadditivity results in 6% lower production costs, primarily stemming from business synergies, lower transactional costs, and optimization of productive resources and facilities. The evidence justifies, ceteris paribus, that the provision by a single firm is preferable to multiple firms in the analysis case. Implications for policies are straightforward. The one-fit rule approach fails to set the best condition for policymakers to create a level playing field transparently and efficiently for industry operators to perform efficiently.
The Establishment and Application of Indirect 3AB-ELISA for the Detection of Antibodies against Senecavirus A
Authors: Yan Junfang , Gao Yanni , Li Jian , Li Minjing , Guo Chengyi , Bai Juan , Jiang Ping
Published: March 2023

Senecavirus A (SVA) is an emerging pathogen that negatively affects the pig industry in China. Affected animals present vesicular lesions which are indistinguishable from other vesicular diseases. To date, there is no commercial vaccine that can be used to control SVA infection in China. In this study, recombinant SVA 3AB, 2C, 3C, 3D, L and VP1 proteins are expressed by using a prokaryotic expression system. The kinetics of the presence and levels of SVA antibodies with SVA-inoculated pig serum show that 3AB has the best antigenicity. An indirect enzyme-linked immunosorbent assay (ELISA) is developed with the 3AB protein, exhibiting a sensitivity of 91.3% and no cross-reaction with serum antibodies against PRRSV, CSFV, PRV, PCV2 or O-type FMDV. Given the high sensitivity and specificity of this approach, a nine-year (2014–2022) retrospective and prospective serological study is conducted to determine the epidemiological profile and dynamics of SVA in East China. Although SVA seropositivity declined markedly from 2016 (98.85%) to 2022 (62.40%), SVA transmission continues in China. Consequently, the SVA 3AB-based indirect ELISA has good sensitivity and specificity and is suitable for viral detection, field surveillance and epidemiological studies.
Development of Porcine Monoclonal Antibodies with In Vitro Neutralizing Activity against Classical Swine Fever Virus from C-Strain E2-Specific Single B Cells
Authors: Wang Lihua , Madera Rachel , Li Yuzhen , Gladue Douglas P. , Borca Manuel V. , McIntosh Michael T. , Shi Jishu
Published: March 2023

Neutralizing antibodies (nAbs) can be used before or after infection to prevent or treat viral diseases. However, there are few efficacious nAbs against classical swine fever virus (CSFV) that have been produced, especially the porcine-originated nAbs. In this study, we generated three porcine monoclonal antibodies (mAbs) with in vitro neutralizing activity against CSFV, aiming to facilitate the development of passive antibody vaccines or antiviral drugs against CSFV that offer the advantages of stability and low immunogenicity. Pigs were immunized with the C-strain E2 (CE2) subunit vaccine, KNB-E2. At 42 days post vaccination (DPV), CE2-specific single B cells were isolated via fluorescent-activated cell sorting (FACS) baited by Alexa Fluor™ 647-labeled CE2 (positive), goat anti-porcine IgG (H + L)-FITC antibody (positive), PE mouse anti-pig CD3ε (negative) and PE mouse anti-pig CD8a (negative). The full coding region of IgG heavy (H) chains and light (L) chains was amplified by reverse transcription-polymerase chain reaction (RT-PCR). Overall, we obtained 3 IgG H chains, 9 kappa L chains and 36 lambda L chains, which include three paired chains (two H + κ and one H + λ). CE2-specific mAbs were successfully expressed in 293T cells with the three paired chains. The mAbs exhibit potent neutralizing activity against CSFVs. They can protect ST cells from infections in vitro with potent IC50 values from 14.43 µg/mL to 25.98 µg/mL for the CSFV C-strain, and 27.66 µg/mL to 42.61 µg/mL for the CSFV Alfort strain. This study is the first report to describe the amplification of whole-porcine IgG genes from single B cells of KNB-E2-vaccinated pig. The method is versatile, sensitive, and reliable. The generated natural porcine nAbs can be used to develop long-acting and low-immunogenicity passive antibody vaccine or anti-CSFV agents for CSF control and prevention.
Salivary Antibody Responses to Two COVID-19 Vaccines following Different Vaccination Regimens
Authors: Alkharaan Hassan , Al-Qarni Hatem , Aldosari Muath A. , Alsaloum Mohammed , Aldakheel Ghada , Alenazi Mohammed W. , Alharbi Naif Khalaf
Published: March 2023

Background: To date, little is known about the salivary mucosal immune response following different COVID-19 vaccine types or after a booster (3rd) dose of the BNT162b2 (BNT) vaccine. Methods: A total of 301 saliva samples were collected from vaccinated individuals and arranged into two cohorts: cohort 1 (n = 145), samples from individuals who had received two doses against SARS-CoV-2; cohort 2 (n = 156), samples from individuals who had received a booster of BNT vaccine. Cohorts 1 and 2 were sub-stratified into three groups based on the types of first and second doses (homologous BNT/BNT, homologous ChAdOx1/ChAdOx1, or heterologous BNT/ChAdOx1vaccinations). Salivary immunoglobulin G (IgG) response to SARS-CoV-2 spike glycoprotein was measured by ELISA, and clinical demographic data were collected from hospital records or questionnaires. Results: Salivary IgG antibody responses against different vaccines, whether homologous or heterogeneous vaccination regimens, showed similar levels in cohorts 1 and 2. Compiling all groups in cohort 1 and 2 showed significant, albeit weak, negative correlations between salivary IgG levels and time (r = −0.2, p = 0.03; r = −0.27, p = 0.003, respectively). In cohort 2, the durability of salivary IgG after a booster dose of BNT162b2 significantly dropped after 3 months compared to the <1 month and 1–3 months groups. Conclusions: Different COVID-19 vaccine types and regimens elicit similar salivary anti-SARS-CoV-2 IgG with modest waning over time. Boosting with BNT162b2 vaccine did not produce an evident increase in mucosal IgG response whereby COVID-19 recovered subjects show higher salivary IgG than naive, post-vaccination subjects. The ChAdOx1/ChAdOx1 regimen showed better correlation between salivary IgG levels and durability. These findings highlight the importance of developing oral or intra-nasal vaccines to induce stronger mucosal immunity.
COVID-19 mRNA Vaccines: The Molecular Basis of Some Adverse Events
Authors: Giannotta Girolamo , Murrone Antonio , Giannotta Nicola
Published: March 2023

Each injection of any known vaccine results in a strong expression of pro-inflammatory cytokines. This is the result of the innate immune system activation, without which no adaptive response to the injection of vaccines is possible. Unfortunately, the degree of inflammation produced by COVID-19 mRNA vaccines is variable, probably depending on genetic background and previous immune experiences, which through epigenetic modifications could have made the innate immune system of each individual tolerant or reactive to subsequent immune stimulations.We hypothesize that we can move from a limited pro-inflammatory condition to conditions of increasing expression of pro-inflammatory cytokines that can culminate in multisystem hyperinflammatory syndromes following COVID-19 mRNA vaccines (MIS-V). We have graphically represented this idea in a hypothetical inflammatory pyramid (IP) and we have correlated the time factor to the degree of inflammation produced after the injection of vaccines. Furthermore, we have placed the clinical manifestations within this hypothetical IP, correlating them to the degree of inflammation produced. Surprisingly, excluding the possible presence of an early MIS-V, the time factor and the complexity of clinical manifestations are correlated to the increasing degree of inflammation: symptoms, heart disease and syndromes (MIS-V).
Appraisal of Land Cover and Climate Change Impacts on Water Resources: A Case Study of Mohmand Dam Catchment, Pakistan
Authors: Masood Muhammad Umer , Khan Noor Muhammad , Haider Saif , Anjum Muhammad Naveed , Chen Xi , Gulakhmadov Aminjon , Iqbal Mudassar , Ali Zeshan , Liu Tie
Published: March 2023

Land cover change (LCC) and climate change (CC) impacts on streamflow in high elevated catchments are a great challenge to sustainable management and the development of water resources. This study evaluates the possible future impacts of both land cover and climate change on the streamflows in the Mohmand Dam catchment, Pakistan, by utilizing the semi-distributed hydrological model known as the Soil and Water Assessment Tool (SWAT), along with the latest Coupled Model Intercomparison Project phase 6 (CMIP6) dataset of different global climate models (GCMs). The downscaling of the precipitation and temperature data was performed by the CMhyd software. The downscaled precipitation and temperature projections from the best performing GCM, out of four GCMs, under two shared socioeconomic pathways (SSP2 and SSP5) and future land cover conditions were forced in a calibrated hydrological model (SWAT model). Compared to the baseline period (1990–2015), the outputs from the selected GCM indicated an increase in the average monthly precipitation, and the maximum and minimum temperature in the study area under both the SSP2 and SSP5 scenarios, by the end of the 21st century. It is expected that the increase in precipitation for the period 2016–2100 is 10.5% and 11.4% under the SSP2 and SSP5 scenarios, respectively. Simulated results from the SWAT model showed significant impacts from the projected climate and land cover changes on Mohmand Dam flows that include: (a) an increase in the overall mean annual flow ranging from 13.7% to 34.8%, whereas the mean monthly flows of June, July and August decreased, and (b) a shift in the peak flows in the Mohmand catchment from July to June. It is concluded that the projected climate changes can substantially influence the seasonality of flows at the Mohmand Dam site. Climate and land cover change impacts are significant, so project planners and managers must include CC and LCC impacts in the proposed operational strategy.
Submerged Macrophyte Restoration in Enclosure: A Proper Way for Ecological Remediation of Shallow Lakes?
Authors: Hu Shenghua , Chen Xiaofei , Huang Xiaolong , Wu Chenxi
Published: March 2023

Degradation of lake ecosystem is a common problem existing in many countries. Remediation of degraded lake is urgently needed in order to maintain water safety and lake ecosystem health. Restoration of submerged macrophyte is considered as an important measure of ecological remediation of shallow lakes after pollution loading get effectively controlled. Nowadays, enclosures resembling those used in aquaculture historically are widely used for submerged macrophyte restoration. Although submerged macrophyte can be successfully restored in enclosure, it’s contribution to the whole lake ecological remediation is limited. Fish manipulation, which reduces fish stock and adjusts fish community structure, was found able to improve water quality and promote submerged macrophyte restoration in many lakes. However, the role of fish in ecological restoration do not receive enough attention in many ecological remediation projects. Future studies are required to better understand the role of fish in lake nutrient cycle and the influence on submerged macrophyte to help develop theory that better guide the fish manipulation for the ecological remediation in shallow lakes. In the end, we want to point out that manipulation of fish community structure following by natural restoration and/or artificial planting of submerged macrophyte could be an effective strategy for whole lake ecological remediation of shallow lakes, and suggest that fish manipulation measure should be tested in more ecological remediation projects of shallow lakes worldwide.
Calculation Model of Multi-Well Siphoning and Its Feasibility Analysis of Discharging the Groundwater in Soft Soil
Authors: Shen Qingsong , Wu Chaofeng , Wang Jun , Yuan Shuai , Shang Yuequan , Sun Hongyue
Published: March 2023

The use of a siphon is a drainage method that does not require the use of external power, and siphons are used extensively in practice. The application of siphons in the treatment of soft soils has become a popular approach in recent years. Analyzing the change in the water level in multi-well siphoning is the basis of the application of siphons. The calculation model of multi-well siphoning is established through equivalent transformation. A finite difference method is used to solve the model, and the accuracy is verified by comparing the results with a test of the model and with field tests. Using the numerical model, the feasibility of siphoning drainage in soft soil is demonstrated from two aspects, i.e., well spacing and the permeability coefficient. The results show both the “minimum drop increase” and the “average drop increase”, as well as the spacing of the decreases or increases in the permeability coefficient. When the permeability coefficient is 1 × 10−8 m/s and the well spacing is 2 m, the decrease in the water level is approximately 9.72 m after 100 days of drainage. It is feasible to apply siphon drainage technology to discharge the groundwater in soft soil.
Hydrogeological Responses to Distant Earthquakes in Aseismic Region
Authors: Besedina Alina , Gorbunova Ella , Petukhova Sofia
Published: March 2023

For the first time precise measurements of the groundwater level variations in the territory of the Mikhnevo geophysical observatory in an aseismic region (Moscow region, Russia) have been carried out since February 2008 at a sampling rate of 1 Hz. The groundwater level variations under quasi-stationary filtration are considered indicators of the dynamic deformation of a fluid-saturated reservoir represented by carbonate-terrigenous sediments. Both permanent (long-term) factors—atmospheric pressure, lunar-solar tides, and periodic (short-term) ones—seismic impacts from distant earthquakes, are used as probing signals for analyzing the filtration parameters of aquifers of different ages. Hydrogeological responses to the passage of seismic waves from earthquakes with magnitudes of 6.1–9.1 with epicentral distances of 1456–16,553 km was recorded in 2010–2023. Dependences of dynamic variations of the pore pressure in the upper weakly confined and lower confined aquifers on the ground velocity are approximated by different regression functions. Spectral analysis of hydrogeological responses made it possible to identify coseismic and postseismic effects from distant earthquakes. The postseismic effects in the form of an episodic increase in the pore pressure may be caused by a skin effect—clogging of microcracks nearby the wellbore by colloidal particles under intensive seismic impact.
Blue Shark (Prionace glauca) Distribution in the Pacific Ocean: A Look at Continuity and Size Differences
Authors: Li Weiwen , Dai Xiaojie , Staples Kevin W. , Chen Bin , Huang Hao , Tian Siquan
Published: March 2023

Blue shark (Prionace glauca) is a major bycatch species in the long-line and gill-net Pacific Ocean tuna fisheries, and the population structure is critical for fishery management. We employed generalized additive models to analyze the fork lengths of blue sharks and biological data (i.e., feeding level, sex, and genetic data), as well as environmental and spatial variables (i.e., sea surface temperature, month, longitude, and latitude) collected from 2011 to 2014 by the Chinese Thunnus alalunga long-line tuna fishery observer program. Fork length was significantly affected (p < 0.05) with location (latitude and longitude) and sex, and positively effected with sea surface temperature. No relationships were found between fork length and feeding level, month, and genetic data. We detected fork length differences among blue sharks over the range of the observed data, but the genetic data implied a panmictic population. Thus, we hypothesize that the genetic similarity was so close that it could not be well separated. Based on the precautionary principle, we recommend that the blue shark in the Pacific Ocean should be managed as two independent populations to ensure its sustainable use.
Hydrochemical Characterization of Surface Water and Groundwater in the Crystalline Basement Aquifer System in the Pra Basin (Ghana)
Authors: Manu Evans , De Lucia Marco , Kühn Michael
Published: March 2023

The quality of groundwater resources in the Pra Basin (Ghana) is threatened by ongoing river pollution from illegal mining. To date, there are very limited data and literature on the hydrochemical characteristics of the basin. For the first time, we provide regional hydrochemical data on surface water and groundwater to gain insight into the geochemical processes and quality for drinking and irrigation purposes. We collected 90 samples from surface water (rivers) and groundwater (boreholes) and analysed them for their chemical parameters. We performed a water quality assessment using conventional water quality rating indices for drinking water and irrigation. Cluster and factor analysis were performed on the hydrochemical data to learn the chemical variations in the hydrochemical data. Bivariate ion plots were used to interpret the plausible geochemical processes controlling the composition of dissolved ions in surface water and groundwater. The water quality assessment using Water Quality Index (WQI) revealed that 74% of surface water and 20% of groundwater samples are of poor drinking quality and, therefore, cannot be used for drinking purposes. For irrigation, surface water and groundwater are of good quality based on Sodium Adsorption Ratio (SAR), Wilcox diagram and United States Salinity (USSL) indices. However, Mn and Fe (total) concentrations observed in most surface water samples are above the acceptable limit for irrigation and therefore require treatment to avoid soil acidification and loss of availability of vital soil nutrients. Manganese and iron (total) are identified as the main contaminants affecting the basin’s water quality. The hierarchical cluster analysis highlights the heterogeneity in the regional hydrochemical data, which showed three distinct spatial associations based on elevation differences. Groundwater composition chemically evolves from a Ca–HCO3 to a Na–HCO3 and finally to a Na–Cl water type along the flow regime from the recharge to the discharge zone. The bivariate ion plot and the factor analysis underscore silicate weathering, carbonate dissolution and ion exchange as the most likely geochemical processes driving the hydrochemical evolution of the Pra Basin groundwater. Going forward, geochemical models should be implemented to elucidate the dominant reaction pathways driving the evolution of groundwater chemistry in the Pra Basin.
High-Frequency Signal Injection-Based Sensorless Control for Dual-Armature Flux-Switching Permanent Magnet Machine
Authors: Wu Lijian , Yi Jiali , Lyu Zekai , Zhang Zhengxiang , Hu Sideng
Published: March 2023

The new topology of the dual-armature flux-switching permanent magnet machine (DA-FSPM) leads to new characteristics and issues in the control of the machine, of which the mutual inductance of the two sets of armature windings is the most important one. This paper proposes a novel position–sensorless control method based on high-frequency injection (HFI) for DA-FSPM. The high-frequency model of the machine is derived, and the theory of the position estimation method is proposed. Different from the conventional HFI-based position estimation method, the proposed method utilizes the mutual inductance of the DA-FSPM rather than the machine saliency. Meanwhile, because the extracted position information based on the mutual inductance is more obvious, the proposed method also has better steady and dynamic performance. Then, the position observer based on the phase lock loop and the initial position detection method for the DA-FSPM is proposed. The experiments are executed on a DA-FSPM prototype with three-phase stator windings and five-phase rotor windings to prove the effectiveness and superiority of the proposed method.
Bi-Directional Cuk Equalizer-Based Li-Ion Battery Pack Equalization Control Strategy Research
Authors: Wang Xiaolu , Tan Zefu , Cai Li , Lei Guoping , Dai Nina
Published: March 2023

For the secure usage of battery charging and discharging within electric vehicles, the study of cell pack equalization technology is essential. Therefore, in this paper, an improved Bidirectional Cuk equalizer (BCEQ) structure based on a variable-domain fuzzy PID (VFPID) control equalization strategy is recommended in stages. With the new equalization topology, only half of the capacitive and inductive components are needed to transfer energy between any two individual cells in the power supply. In addition, the proposed VFPID control strategy further improves the efficiency of the equalization model by dynamically adjusting the magnitude of the equalization current parameters. Through simulation experiments, the improved topology was capable of substantially lessening the equalization time and increasing energy utilization by more than 4%. In comparison with the fuzzy PID (FPID) algorithm, around 27.3% faster equalization times can be achieved with the VFPID algorithm; the VFPID algorithm also performed well under the Dynamic Stress Test (DST) condition, demonstrating that the topology and equalization strategy suggested in this paper can successfully address the inconsistency of the FPID algorithm. It has been revealed that the topology and equalization methodology offered in this paper is effective in solving the battery pack inconsistency.
Epidemiological situation on viral hepatitis В and С among medical workers in the Voronezh region
Authors:   Budgetary Health Institution «Voronezh Regional Clinical Center AIDS Prevention and Control», Voronezh, Russia, Federal State Budgetary Educational Institution of Higher Education «Voronezh State Medical University named after N. N. Burdenko» of the Russian Federation Ministry of Health, Voronezh, Russia, Chemodurova Yu. V. , Mamchik N. P. ,   Federal State Budgetary Educational Institution of Higher Education «Voronezh State Medical University named after N. N. Burdenko» of the Russian Federation Ministry of Health, Voronezh, Russia, Sitnik T. N. ,   Budgetary Health Institution «Voronezh Regional Clinical Center AIDS Prevention and Control», Voronezh, Russia, Federal State Budgetary Educational Institution of Higher Education «Voronezh State Medical University named after N. N. Burdenko» of the Russian Federation Ministry of Health, Voronezh, Russia, Gabbasova N. V. ,   Federal State Budgetary Educational Institution of Higher Education «Voronezh State Medical University named after N. N. Burdenko» of the Russian Federation Ministry of Health, Voronezh, Russia
Published: March 2023

One of the leading problems of modern health care is nosocomial infection of health care workers with bloodborne infections viruses, including parenteral viral hepatitis B and C. The aim of the study was to assess the frequency of detection of markers of hepatitis B and C based on the results of screening studies and the incidence of viral hepatitis B and C among medical workers and the general population of the Voronezh region, to analyze the structure of emergency situations in medical organizations. A retrospective descriptive study was conducted, the materials of which were data on the frequency of occurrence of markers of parenteral hepatitis, the incidence of viral hepatitis B and C among medical workers, and the frequency of registration of emergency situations. Analysis of the incidence and results of screening examinations for markers of viral hepatitis B and C among medical workers in the Voronezh region for the period 2011–2018 revealed a pronounced trend towards a decrease in the prevalence of this pathology. However, the indicators remain at a consistently high level among the staff of the hemodialysis, hematology, and surgery departments. The annual frequency of registering emergencies for the specified period was from 1.7 to 3.1 per 1000 workers. It has been established that most often medical accidents occur among middle medical personnel and auxiliary health care workers. More than half of the respondents (53.0 %) answered in the affirmative to the question about the emergency situation in their professional activities, only a fourth (26.0 %) carried out emergency postexposure prophylaxis of viral hepatitis B. Insufficient adherence of medical workers to timely accounting of injuries, low level of knowledge of algorithms of behavior in an emergency situation, a significant underestimation of emergency situations in medical organizations require close attention.
Clinical and immunological features of COVID-19 at different stages of the course of the disease
Authors:   Osh State University, Osh, Kyrgyz Republic, Abdimomunova B. T. , Zholdoshev S. T. ,   Osh State University, Osh, Kyrgyz Republic
Published: March 2023

A retrospective analysis of clinical and immunological manifestations of COVID-19 was performed in 419 patients (women n=167 (39.8 %) men n= 252 (60.2 %)) aged 20 to 80 years. Mild stage I (early infection) in patients was mainly manifested by symptoms characteristic of other acute respiratory infections. Distinctive features were the loss (distortion) of smell and taste. The clinical manifestations of stage II (pulmonary) were determined by lung damage in the form of pneumonitis. Stage III (hyperinflammatory response) it was characterized by severe lung damage, involvement of other organs in the pathological process as a consequence of a hyperimmune reaction. The determination of cellular and humoral immunity indicators reflected the severity of damage to the body's immune system, and, accordingly, the severity of the course of coronavirus infection. The variety of clinical manifestations and examination results confirms that COVID-19 is a systemic disease with a multi-organ lesion that requires in-depth study of its clinical and immunological features.
Analysis of the radiation levels in the population of the Oryol region during X-ray radiological studies
Authors:   Oryol State University named after I. Turgenev, Oryol, Russia, Simonova V. G.
Published: March 2023

The article deals with the problems of medical exposure (ME), since it is the predominant source of artificial exposure and one of the essential types of exposure of the population as a whole. In the course of the study, the dose load of ionizing radiation sources (IRS) used for medical purposes on the population of the Oryol region in 1998–2018 was analyzed based on the results of the analysis of the fleet of X-ray diagnostic equipment, data from radiation passports and official annual medical statistics. To achieve the goal of the study, statistical methods were used, methods of retrospective epidemiological analysis of data on medical exposure of the population of the Oryol region. We used data from 15 million X-ray procedures recorded by the official annual medical statistics of dynamic changes over 20 years from 1998 to 2018 (form No. 30) and data from 800 annual No. 3‑DOZ — forms of federal state statistical observation in the Oryol region for the period 2001–2018 provided by medical institutions. The patient pays for information with a high risk of radiation exposure. The reason for the increase in medical exposure is the increasing use of interventional radiology in recent years. Medical exposure carries the risk of stochastic effects. The incidence of malignant neoplasms among the population of the Oryol region has increased by 14 % over the past 5 years, adolescents — 1.3 times, children under 14–1.4 times; congenital anomalies and malformations were recorded — 1.3 times more, in children under 14 years of age there was an excess of 4.5 %. The health indicators of the population of the Oryol region are considered unsatisfactory in terms of the incidence of malignant neoplasms, mortality and congenital malformations. As a result of the research, proposals were made to optimize the dose load and reduce the radiation hazard to the health of the population of the Oryol Region. Recommendations have also been developed to reduce the radiation doses to the personnel of medical and prophylactic organizations, to re-equip the health care facilities with modern low-dose devices.
Disciplinary responsibility of an employee: problems of legal regulation
Authors:   Department of Labor and Social Security Legislation of the Institute of Legislation and Comparative Law under the Government of the Russian Federation, Lomakina L.A.
Published: March 2023

The article discusses some problematic issues of disciplinary responsibility of employees for violation of labor discipline. Revealing in the article the concept of disciplinary responsibility of employees through its main features and principles, it is possible not only to correctly understand the essence of the legal norm, but also to predetermine the content and essence of future legal norms, and the analysis of judicial practice has shown that the explanations of the Supreme Court of the Russian Federation contribute not only to the monotonous application of the law, but also have an impact on the improvement of legislation on disciplinary responsibility.
Communication Activities at the Mangongkal Holi Ceremony
Authors: Prayoga I , Situmorang M
Published: March 2023

The purpose of this study was to determine the communication activities at the Mangongkal Holi ceremony. The method in this research is used descriptive method with a qualitative approach. The results of the study indicate that the communication activities at the Mangongkal Holi traditional ceremony include the clothes worn which mean joy and joy. The movements displayed at the mangongkal holi ceremony show courtesy and mutual respect within the family. There are 4 (four) traditional Batak musical instruments, namely tagading, ogung, serune, and hesek which are called gondang. The conclusion of this research is that nonverbal meaning is contained in the mangongkal holi traditional ceremony. Where the mangongkal holi traditional ceremony contains meaning conveyed through clothing, movement, and music, each part of which has its own meaning.
Impact Termination of Employment for Performance Company in Indonesia During the Covid-19
Authors:   Magister Manajemen, Universitas Komputer Indonesia, Indonesia, Vistawati Laela , Wahdiniwaty Rahma
Published: March 2023

The Covid-19 Pandemic period has changed all current human activities such as the education sector, social governance, culture, economy and so on. One aspect that is in the public spotlight is the economic aspect. This is because many companies engaged in the economy have had to temporarily stop due to the implementation of Large-Scale Social Restrictions (PSBB) in various regions, countries and even the world, as a result various companies have closed their businesses. In addition, employees who originally worked later have to be laid off and some employees have terminated their working relationships in this pandemic situation. The phenomenon of termination of employment is a form of termination of employment for certain reasons, during this pandemic the reason for layoffs is that the company loses money which results in the company's inability to pay its employees’ wages. Then during this pandemic, the dismissed employees will carry out work activities on a virtual basis, namely by using digital media such as zoom, google meet, skype, Microsoft team and others. This journal will discuss the impact termination of employment for performance in Indonesia during the Covid-19 pandemic.
Improving Revisit Intention Through Physical Evidence and Tourist Experience (Case Study at Water World Jatiluhur)
Authors:   Departement of management STIE Dr. KHEZ. Muttaqien Purwakarta, Kusumadewi A N , Mawardi A ,   Departement of management STIE Dr. KHEZ. Muttaqien Purwakarta, Patoni P ,   Departement of management STIE Dr. KHEZ. Muttaqien Purwakarta, Riana A D ,   Departement of management STIE Dr. KHEZ. Muttaqien Purwakarta
Published: March 2023

This study aims to see the effect of Physical Evidence as place attractiveness in increasing Revisit Intention on tourists and to what extent the influence of Tourist Experience felt by the tourists can affect Revisit Intention in Jatiluhur Water World tourism object. This research uses a quantitative research model, with the method used is descriptive quantitative method and a sample of 100 respondents from tourists who have visited Jatiluhur Water World.. The study shows that Physical Evidence has significant effect on Revisit Intention, then the Tourist Experiences significantly affects the increase of tourists in Revisit Intention in Jatiluhur Water World. and for the both variables, Physical Evidence and Tourist Experience significantly influence Revisit Intention for the tourists of Jatiluhur Water World tourism object. Physical Evidence and Travel Experience have a significant effect on Revisit Intetion on Jatiluhur Water World tourists
Proposed Improvement of Talent Management in Regional-Owned Enterprises (BUMD) Services and Tourism in West Java Using Structural Equation Modeling Method
Authors:   School of Industrial Engineering, Industrial Enginering, Telkom University, Fauziyah Rahma , Triwibisono Christanto ,   School of Industrial Engineering, Industrial Enginering, Telkom University, Martini Sri ,   School of Industrial Engineering, Industrial Enginering, Telkom University
Published: March 2023

Ownership of quality human resources in the long term amid current conditions is the most important asset for the organization in maintaining its business. As was done by one of the local government companies in West Java. The company is engaged in services and tourism and implements a talent management system in preparing its human resources. Not only that, this program is carried out to improve the performance of the burglarized employees. Previous research stated that the existence of a good talent management design will have a positive influence on the performance of company employees, especially in some developing countries. Then it is known that the implementation of talent management in this company is still not accompanied by a good design. This condition causes companies to struggle to maintain the performance of their employees. Moreover, the absence of employee involvement also affects the improvement of employee performance. There have been many studies involving the influence between talent management and employee performance, but only a few have involved employee engagement factors in their research, especially in companies engaged in services and tourism. This study was developed to fill this out. The authenticity of this study lies in employee engagement as an additional factor in the model proposed from previous studies. This research then makes the employee engagement factor a mediating variable
The Impact of E-learning on Student Learning Motivation
Authors:   Departemen Akuntansi, Universitas Komputer Indonesia, Indonesia, Komala A R
Published: March 2023

This study aims to determine the impact of e-learning on student learning motivation. Indicators of e-learning include learning and evaluation materials, community, online lecturers, collaboration and multimedia. The indicators of learning motivation include college desire, encouragement to complete college, expectations of attending lectures, awards in lectures, interesting activities during lectures and a conducive environment. Various obstacles in running e-learning such as network unpreparedness, too much task load, less than optimal interactive lecturers and so on became the basis for conducting this research. The method used in this research is descriptive and verification with a quantitative approach. Respondents in this study were 104 students. The source of data in this study is primary data with data collection techniques carried out through survey methods using questionnaires. The analytical method used in this study is the SmartPLS 3.3.3 . software. The results of this study indicate that e-learning has an effect on student learning motivation. The results of data processing show that for e-learning multimedia indicators are still not good and this shows that the learning media, both video, audio and online simulations are still not optimally used as online learning media. As for learning motivation, indicators of college desire, awards for online lectures, interesting activities and a conducive environment have not been obtained optimally by students. This shows that in conducting online lectures it is necessary to have interesting media in conveying material so that student learning motivation is mentioned
Philosophy of Information System Science
Authors:   Department of Computer Science and Information Systems Bina Nusantara University Jakarta, Indonesia, Hiererra E , Kurniawan B ,   Department of Computer Science and Information Systems Bina Nusantara University Jakarta, Indonesia, Saputra P C ,   Department of Computer Science and Information Systems Bina Nusantara University Jakarta, Indonesia, Rawiro D ,   Department of Computer Science and Information Systems Bina Nusantara University Jakarta, Indonesia, Fios Frederikus ,   Department of Computer Science and Information Systems Bina Nusantara University Jakarta, Indonesia
Published: March 2023

Today, humans live in the era of the Industrial Revolution 4.0 where people are very dependent on the presence of Information and Communication Technology (ICT) in carrying out their activities. The Industrial Revolution 4.0 gave birth to a new pattern of life called Society 5.0, which means that humans in carrying out their activities in daily life are closely related to the use of ICT and all kinds of supporting tools. In the era of Society 5.0, humans rely heavily on information systems to support all business processes and digital activities. This research comprehensively explores the scientific philosophy of information systems viewed from the aspects of ontology, epistemology and axiology to find out the scientific basis of information systems viewed from the three aspects
Symbols and Its Functions in Nobara Short Story by Ogawa Mimei
Authors:   Japanese Department, Faculty of Humanities, Universitas Komputer Indonesia, Bandung, Indonesia, Febrianty F
Published: March 2023

Children's literature has a role as a medium for character education. Children's literature has simple characteristics in terms of vocabulary, structure, and expressions to suit the child's cognitive and appreciation level. As a literary work, the element of beauty in children's literature can be seen from the use of simple figurative symbols. This study aimed to describe and analyze the symbols and their functions in the short story Nobara by Ogawa Mimei. The main data is the short story Nobara written by Ogawa Mimei in 1924. The research method uses descriptive analysis with a semiotic approach. The results show that the symbols used in Nobara's short stories include blank symbols, natural symbols, and private symbols which function to provide beauty in literary works but are still well understood by child readers
An Analysing of a Balinese Traditional Gateway Design (Kori Agung) in Puri Agung Ubud, Bali
Authors:   Program Magister Desain, Universitas Komputer Indonesia, Indonesia, Subrata N P E T , Iskandar M S ,   Program Magister Desain, Universitas Komputer Indonesia, Indonesia
Published: March 2023

The purpose of this study was to determine the analysis of the form of the Kori Agung design and ornaments at Puri Agung Ubud. Kori Agung or pemedal is the yard door for the house of someone who is Brahmin or Kshatriya. This Kori Agung, in every form, uses philosophical concepts related to traditional Balinese architecture, each part of the form of Kori Agung contained various ornaments such as Keketusan, Pepatran and Kekarangan. These ornaments give value or meaning to the characteristics of the function of the building. The form of Kori Agung is divided into three parts, namely the head, body, and legs. Each part generally takes ornaments with motifs in the form of faces, lotuses, creepers, jugs, and so on. This study uses a qualitative descriptive method, with data analysis techniques and data collection utilizing field observations and literature related to this research. The Conclusion obtained in this rsearch is in the building Kori Agung in Puri Agung Ubud applying the concept of consideration in tradisional Balinese architecture, namely: the concept of Sanga Mandala, Asta Kosala Kosali, Tri Hita Karana, and Tri Angga. As for the application of ornamens there are some pepatran and keketusan that are common in other Kori Agung, For its character uses Karang Bhoma as a symbolic of the function of the building as a Puri or holy place
Semiotic Analysis of Naked Director 2 Movie Poster
Authors:   Departemen Desain Komunikasi Visual, Universitas Komputer Indonesia, Indonesia, Persada S I P
Published: March 2023

Naked Director 2 is a sequel to the first Naked Director where the film tells about the Adult Film Industry in Japan, the film tells of an adult film director and producer, Toru Muranishi, who achieves his goal of being a legend in the industry. The 1980s where in that year the Adult Film Industry was at its peak as well as satellite technology was just being discovered. The purpose of this study is to find out the meaning of the Naked Director 2 Film Poster so that the meaning of the poster is known to find out the meaning or visual meaning contained in the film poster. An appropriate method is needed where the method that is in accordance with this research is the Roland Semotics Method. Barthes where in this method every visual contained in the poster will analyze its meaning and significance, the benefit of this research is to increase knowledge in the field of semiotics, especially semiotics and a film poster
Augmented Reality at Gedung Sate Museum: Bring The Past To The Present
Authors:   Interior Design Department, Design Faculty, Universitas Komputer Indonesia Bandung, Indonesia, Nazhar Ryanty Derwentyana
Published: March 2023

The purpose of this study is to collect and explain the importance of applying Augmented reality technology to museums to increase the visitors' space experience. The method used is descriptive qualitative, which is supported by a literature review. The author will collect the various advantages of using augmented reality technology in museums with visitors' experience when this technology is seen from previous studies. The Cultural History Museum is a facility that presents cultural heritage. These artifacts and cultural heritage are sometimes presented in incomplete form, and historical stories are sometimes written or told in a rather dull form. AR is a technology that can be a solution so that cultural heritage and artifacts from the past can be presented in a more interactive and fun form. Gedung Sate Museum is one of the museums that uses AR technology for one of its exhibition spaces, discussed in this paper. From observations, there are two kinds of spaces enjoyed by visitors, namely the actual exhibition space and the virtual space presented on the screen. When a visitor looks at the screen, what is visible is an enhanced visual. The situation from the past is represented in a visual form that is combined with the actual state of space to present the past presented on a virtual screen and support from the atmosphere of the room, which is also essential to evoke emotions, memories, and thoughts of visitors. The results of this study can be used to add references to the application of Augmented reality technology, which is suitable to be applied in cultural history museums in Indonesia