bluuebunny/crossref_metadata_2025 huggingface dataset:
Çukurova Üniversitesi Zootekni Bölümü Öğrencilerinin Süt Tüketim Alışkanlıklarının Belirlenmesi
Authors: Çelik Güney Melis
Published: January 2025

Hayvansal gıdalardan biri olan süt, zengin besin madde içerikleri nedeniyle zihin ve beden sağlığı için çok önemlidir. Ancak, modern dünyada süt tüketim alışkanlıkları, bireylerin beslenme tercihleri, yaşam tarzları, ekonomik durumları ve sağlık bilinçleri gibi çeşitli faktörlerden etkilenerek değişim göstermektedir. Bu çalışmada, hayvansal üretim konusunda eğitim alan Çukurova Üniversitesi, Ziraat Fakültesi, Zootekni Bölümü öğrencilerinin süt tüketim alışkanlıklarını belirlemek amaçlanmıştır. Bu amaçla öğrencilere demografik özellikleri ve süt tüketim alışkanlıkları ile ilgili sorular içeren bir anket yapılmıştır. Hayvansal üretim konusunda eğitim alan Zootekni Bölümü öğrencilerinin %85.05’i süt tüketmektedir. Ancak sadece %16.48’i günlük, %28.47’si haftada bir, %47.25’i 2-3 haftada bir süt tükettiğini ifade etmektedir. Günlük süt tüketen öğrencilerin %73.33’ü bir bardak süt ve %38.46 sabah tüketmektedir. Ayrıca, öğrencilerin sütle bulaşan hastalık risklerine karşı yeterli bilgiye sahip olmadığı anlaşılmaktadır. Yapılan ki kare analizi sonucuna göre, annelerin eğitim düzeyi ile öğrencilerin hastalıklar hakkında bilgi sahibi olup olmaması arasında istatistiksel olarak anlamlı bir fark bulunmuştur (p<0.01).
Akdeniz Havzasındaki Ülkelerden Toplanmış Yerel Makarnalık Buğday Triticum durum L Genotiplerinin Adana Koşullarında AgroMorfolojik Özelliklerinin Değerlendirilmesi
Authors: Çakır Esra
Published: January 2025

Bu çalışma, 2018-2019 buğday yetiştirme sezonunda, Akdeniz’e kıyısı olan 5 ülkeye ait (Cezayir, Fas, Suriye, Tunus ve Türkiye) 1296 adet yerel makarnalık buğday genotipinin agro-morfolojik, dane ve kalite özelliklerinin saptanması amacıyla Çukurova Üniversitesi Ziraat Fakültesi Tarla Bitkileri Araştırma alanında alfa latis deneme desenine göre iki tekrarlamalı olarak yürütülmüştür. İncelenen özelliklerle ilgili veriler kullanılarak yapılan varyans analizi sonuçları, incelenen özelliklerin makarnalık buğday genotiplerinin orijin ülkelerine göre istatistiki olarak farklılık gösterdiğini ortaya koymuştur. Çalışmada; yerel makarnalık buğdaylar genotiplerinde başaklanma süresinin 120.20 - 122.34 gün, bitki boyunun 96.04 - 114.40 cm, üst boğum arası (pedinkul) uzunluğunun 24.72 - 27.58 cm, başak uzunluğunun 7.47 - 8.63 cm, başaktaki başakçık sayısının 23.95 - 25.19 adet, başakta dane sayısının 41.25 - 50.84 adet, başakta dane ağırlığının 1.83-2.35 g ve bindane ağırlığının 41.76-48.84 g arasında değiştiği saptanmıştır. Araştırma bulguları, incelenen makarnalık buğday genotiplerinin incelenen özellikler açısından geniş bir varyasyon gösterdikleri, bu bulguların ışığında söz konusu genotiplerin küresel iklim değişikliklerine uygun yeni makarnalık buğday çeşitlerinin geliştirilebilmesi için gen kaynağı olarak kullanılabileceğini göstermiştir.
Yapraktan Vermikompost Uygulamasının Black Magic ve Prima Üzüm Çeşitlerinin Verim, Kalite ve Stoma Özellikleri ile Yaprak Besin Elementi Konsantrasyonuna Etkisi
Authors: Cantürk Sevil
Published: January 2025

Vermikompost, tarımda sürdürülebilirliğin sağlanabilmesi ve bitki gelişiminin desteklenmesi için kullanılan organik gübrelerin başında gelmektedir. Bu çalışmada, 1103 P anacı üzerine aşılı Prima ve Black Magic üzüm çeşitlerinde yapraktan vermikompost uygulamasının ürün verim ve kalitesi ile yaprak stoma özellikleri ve besin elementi konsantrasyonu üzerine etkisi incelenmiştir. Vermikompost uygulaması %0.05, %0.1 ve %0.2 dozlarında, çiçeklenme öncesi, tane tutumu ve ben düşme döneminde yapılmıştır. Tüm vermikompost dozları omca verimi ve salkım ağırlığında artış sağlamakla birlikte, en güçlü etki %0.2 dozundan elde edilmiştir. Omca verimi her iki çeşitte 3229 g (Kontrol) ile 4530 g (%0.2 dozu), salkım ağırlığı 234.6 g (Kontrol) ve 304.8 g (%0.2 dozu) arasında değişmiştir. Tane özellikleri ve suda çözünebilir kuru maddede de artış sağlayan tek uygulama %0.2 dozu olmuştur. Uygulamalar yaprakların besin elementi konsantrasyonu ile stoma yoğunluğunu etkilememiş, ancak stoma eni ve boyu kontrol göre küçülmüştür. Stoma yoğunluğu Prima’da 200.3-388.3 adet mm-2, Black Magic’de 320.3-446.9 adet mm-2 arasında değişmiştir. Sonuç olarak Prima ve Black Magic üzüm çeşitlerinde yapraktan vermikompost uygulamasının verim ve bazı kalite özellikleri üzerinde etkili olduğu, en iyi sonuçların %0.2 dozundan elde edildiği belirlenmiştir.
Karpuzda (Citrullus lanatus L.) Farklı Şekillerde Yapılan Bor Uygulamasının Çiçek Tozu Kalite ve Miktarı Üzerine Etkisi
Authors: Adıgüzel Pınar
Published: January 2025

Meyve tutumunun tohum gelişimine bağlı olduğu karpuzda çiçek tozu kalite ve miktarının yüksek olması meyve verim ve kalitesini artırmaktadır. Çalışmada üç farklı karpuz çeşitlerinde yapraktan, topraktan ve toprak+yapraktan bor uygulamasının çiçek tozu canlılık-çimlenme düzeyleri, çiçek tozu miktarı ve normal gelişmiş çiçek tozu oranı üzerine etkileri araştırılmıştır. Ayrıca çiçek tozları 2 farklı dönemde örneklenerek borun çiçekleri hangi dönemde etkilemeye başladığı ve etkinin ne kadar sürdüğü araştırılmıştır. Çalışma sonucunda borun özellikle çiçek tozu çimlenme düzeyi ile çiçek tozu sayısını olumlu yönde etkilediği, çiçek tozu canlılık ve oranında önemli bir etki yapmadığı, topraktan bor uygulamasının uygulama kolaylığı açısından daha ön plana çıktığı söylenebilir.
Investigation Of The Effect Of Apricot Fibre Addition On The Chemical And Sensory Properties Of Peanut Butter
Authors: Bozdoğan Adnan
Published: January 2025

In this study, the effect of different ratios of apricot fibre (0%, 1%, 2%, 4%, 8% and 16%) on the chemical and sensory properties of peanut butter was investigated. When the results of chemical analysis of apricot fibre added peanut butter were evaluated, total acidity, pH and total phenol compounds increased as the amount of apricot fibre increased, while dry matter and protein values decreased (p<0.05). As a result of sensory evaluation, the difference between the peanut butters in terms of structure, taste, colour and general taste level was found to be significant (p<0.05) and peanut butter containing 4% apricot fibre received the highest score. As a result, the production of peanut butter containing 4% apricot fibre can be recommended.
INTERPRETATIONS OF SELF-EMPLOYMENT IN THE WORKS OF DOMESTIC SCIENTISTS AND ITS LEGISLATIVE REGULATION
Authors:   Novosibirsk State University of Economics and Management, Volovskaya Nina M.
Published: January 2025

The article presents more than 40 views of scientists on approaches to the formulation of the term “self-employment” and years of publication. The experiment made it possible to legalize income from self-employment and increased budget revenues from independent activities. However, the legislative acts currently adopted do not include interpretations of the concept of “self-employment”; a number of problems of citizens who have switched to the new tax regime have not been resolved. The article states the need to amend the legislation and makes a proposal to supplement the Employment Law by distinguishing two types of employment: hired employment and self-employment, clarifying the terminology on the conceptual apparatus and the status of self-employment, social and legal protection of subjects.
MONITORING THE FORMATION OF SPECIALIZED COMPETENCIES AMONG STUDENTS AS A MEANS OF QUALITY MANAGEMENT OF PEDAGOGICAL EDUCATION
Authors:   Yaroslavl State Pedagogical University named after K. D. Ushinsky, Melnikova Inna I. , Groshenkova Victoria A. ,   Yaroslavl State Pedagogical University named after K. D. Ushinsky, Bairova Anastasia E. ,   Yaroslavl State Pedagogical University named after K. D. Ushinsky
Published: January 2025

The article discusses issues related to monitoring and evaluating the effectiveness of the formation of specialized professional competencies among students of pedagogical universities. These competencies are not present in the standard of higher pedagogical education, their formulations, indicators and assessment tools are developed by each university independently. The authors highlight and analyze the experience of the Defectology Faculty of K.D. Ushinsky YAGPU in the development and monitoring of specialized competencies among undergraduate students. The article provides a theoretical and methodological justification for the technology of developing the monitoring content: the stages of work, recommended evaluation tools, requirements for their quality and quantity, and methods of processing the results obtained.
Clinical and demographic predictors of heart failure outcomes: A machine learning perspective
Authors: Chitta Shivaprasad , Chandu Supriya , Chaitanya Katha Krishna , Sundar Junapudi Syam , Kumar Yata Vinod , Junapudi Sunil
Published: January 2025

Heart failure (HF) is a multifaceted clinical condition associated with high morbidity and mortality rates. It is an increasing public health concern, impacting millions globally and placing considerable strain on healthcare systems. In recent decades, there has been a growing interest in using machine learning techniques to predict HF outcomes. Hence, this study aims to explore the clinical and demographic characteristics associated with HF outcomes using a comprehensive dataset obtained from Kaggle. The dataset, “Heart Failure Clinical Records.csv,” was preprocessed to address missing values and prepared for analysis. Feature importance analysis and correlation matrix computations were conducted to identify significant predictors of death events among HF patients, including age, serum creatinine, and ejection fraction. Various machine learning models, such as logistic regression, random forest, support vector machine, and gradient boosting machine, were employed to predict death events. The results revealed varying levels of performance among the models, with some demonstrating promising accuracy and predictive power. However, further refinement of these predictive models is warranted to enhance clinical decision-making and patient care in HF management. Overall, this study underscores the value of data-driven approaches in understanding HF outcomes and highlights the necessity for ongoing research in this field.
Agile Coaching: Effectiveness and Best Practices for Successful Scrum Adoption, and Identification and Analysis of Challenges in Scrum
Authors: - Adya Mishra
Published: January 2025

Agile coaching plays an important role in successfully adopting Scrum and overcoming challenges associated with its implementation. Agile coaches support teams by providing resources, tools, and frameworks that allow them to solve problems independently and make data-driven decisions. This article reviews the effectiveness of Agile coaching, discusses the Scrum and Agile adoption challenges, outlines best practices for successful Scrum adoption, and examines the problems Organizations face when implementing Scrum. Scrum has been the most widely adopted Agile methodology over the past decade. While Scrum plays an important role in the success of Agile development, it does come with challenges. A custom model that was transformed from the Diffusion of Innovation theoretical model was developed to detect the Scrum adoption challenges referred to as the Scrum Adoption Challenges Detection Model (SACDM). This model consists of four constructs: i) Individual factors, ii) Team factors, iii) Organizational factors, and iv) Technology factors. Agile has become a hot topic among stakeholders over the last few years. Out of many agile methodologies, Scrum has become at the top of the list as a framework.
Enhancing SAP HANA SQL Query Framework for Faster Processing and Cost Efficiency in SAP SuccessFactors Learning
Authors: - Pradeep Kumar
Published: January 2025

SAP SuccessFactors Learning, a legacy application built on Apache Tomcat and Java, was migrated from Oracle to SAP HANA, introducing significant challenges due to the differences in database execution engines. This paper proposes a dynamic SQL Converter framework that transforms Oracle-specific SQL queries into HANA-compatible queries at runtime, supported by a multi-level caching mechanism based on the Least Recently Used (LRU) policy. Performance tests with 10,000 concurrent users and 600 hits per second demonstrated a 15.6% reduction in CPU usage, a 12.5% decrease in JVM heap size, and a 12.7% improvement in response time. Future enhancements will explore AI/ML-driven caching strategies and further optimization for specific query types to ensure scalability and cost efficiency.
Integration Testing of SAP IDocs with external systems and Testing Frameworks
Authors: - Sireesha Perabathini
Published: January 2025

This paper explores the integration testing of SAP IDocs with third-party systems, its importance, challenges, and methodologies for achieving consistency, error handling, and reliability of data in communication between SAP and third-party applications. This paper provides an overview of various SAP IDoc integration testing frameworks and tools for testing covering both SAP’s internal solutions and third-party tools, accompanied by a comparative analysis. It also discusses recommended best practices and methodologies for effective Integration Testing.
A Technical Review Of Dynamic And Mixed Approach For Health Data Extraction, Transformation And Loading Process
Authors: - Adya Mishra
Published: January 2025

Healthcare data originates from a diverse array of sources—including electronic health records (EHRs), laboratory systems, wearable devices, and unstructured clinical text—making its integration a complex endeavor. Traditional extraction, transformation, and loading (ETL) pipelines, though foundational, often struggle to keep pace with evolving data schemas, regulatory obligations, and the need for real-time insights. This paper provides a technical review of dynamic and mixed ETL strategies tailored specifically for health data. Dynamic approaches emphasize adaptive schema discovery, rule-based transformations, and metadata-driven designs that automatically adjust to new and updated data sources, reducing manual reconfiguration. Mixed ETL models integrate both real-time streaming and batch processing, enabling healthcare organizations to process time-critical clinical data immediately while performing more complex transformations on larger datasets at scheduled intervals. Key challenges—including data quality assurance, regulatory compliance, and the requirement for robust security—are addressed alongside recommended best practices for metadata management, rule engines, and orchestration tools. The review further highlights implementation considerations and future trends, such as AI-driven data integration, serverless architectures, and data mesh paradigms. By adopting these flexible, scalable ETL approaches, healthcare institutions can enhance the accuracy, timeliness, and security of patient data analytics—ultimately improving clinical decision-making and patient outcomes.
Talent identification and development in judo: A systematic review
Authors: Aparecida de Souza Ribeiro Aline , Zacaron Werneck Francisco , Guilherme Vieira João , Sant’Ana Leandro , Johnston Kathryn , Baker Joseph , Macedo Vianna Jeferson
Published: January 2025

This review synthesizes the existing literature about talent identification and development in judo and provides evidence-based suggestions to help researchers and practitioners in this area. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to identify relevant studies (n = 45). The mean quality of the evidence was 94.0%. Most of the studies were published between the years 2014 and 2021 with cross-sectional designs and group comparisons or performance prediction. Studies used batteries of tests focused on expert or advanced samples and measured individual constraints. Few studies examined female samples, psychological skills or biological maturation. Only 20% of the studies used multivariate analyses. On closer examination, there was a high degree of variability in the indicators that were found to discriminate between skilled and less-skilled judo athletes, predict performance and/or predict career pathway. Research in talent identification and development in judo has generally focused on individual constraints related to anthropometric and physiological characteristics, and technical skills in cross-sectional designs. Very little is known about what talent indicators discriminate high skilled judo athletes or predict actual performance or future success. Future research should adopt multidimensional and longitudinal approaches that integrate existing findings about the maturational, psychological and environmental aspects of judo for tracking the most talented judo athletes, especially in female samples.
ANALISIS PENANGGULANGAN BANJIR DI DAERAH KECAMATAN KARANGANYAR KABUPATEN DEMAK
Authors: Istianah Istianah
Published: January 2025

Banjir merupakan bencana alam yang disebabkan oleh peningkatan debit sungai, seperti yang terjadi pada Februari 2024 di Kecamatan Karanganyar akibat luapan debit Sungai Wulan. Penelitian ini bertujuan untuk menganalisis debit banjir dan memberikan rekomendasi solusi penanggulangan. Dengan menggunakan metode Hidrograf Satuan Sintetis (HSS) Nakayasu, debit banjir kala ulang 10 tahun ditemukan sebesar 3.829,424 m³/detik, sementara kapasitas eksisting Sungai Wulan adalah 10.173,47 m³/detik. Untuk mencegah luapan air di masa depan, diperlukan peninggian tanggul setinggi ±1 meter agar mampu menahan debit hingga 13.882,51 m³/detik. Penelitian ini memberikan solusi praktis untuk pengendalian banjir di daerah tersebut.
Productivity Analysis of Construction Workers During The Tobacco Growing Season in Sampang Regency
Authors:   Program Studi Teknik Sipil, Fakultas Teknik, Universitas Madura, Asmaroni Dedy , Zabadi Fairuz ,   Program Studi Teknik Sipil, Fakultas Teknik, Universitas Madura
Published: January 2025

Labor productivity is one of the main elements in determining the successful implementation of a construction project, one of the jobs that require a productive workforce is Fc' 25 Mpa Wiremesh Cement Concrete Pavement (M8). This research was conducted with the aim of knowing the level of productivity in Cement Concrete Pavement Fc' 25 Mpa Wiremesh and then compared with AHSP Bina Marga 2022 or Permen PUPR RI No. 1 of 2022 and mentions the solutions provided to the obstacles in the field during the implementation of the Fc' 25 Mpa Wiremesh Cement Concrete Pavement project in the field. The results obtained from the average calculation of the analysis of the work productivity of Cement Concrete Pavement Fc' 25 Mpa Wiremesh on the Karang Dalem â€“ Patarongan Road Improvement project in Sampang District obtained the calculation results of 30.77 m3/OH for the foreman and 30.81 m3/ OH for workers, while the calculation of AHSP Bina Marga 2022 yields 20.75 m3/OH for foremen and 33.43 m3/OH for workers. In the Torjun â€“ Pangarengan Road Improvement project in Torjun District, the calculations obtained results of 31.94 m3/OH for the foreman and 32.10 m3/OH for the workers, while the 2022 AHSP Bina Marga calculation obtained results of 20.75 m3/OH for the foreman and 37, 05 m3/OH for workers. Furthermore, in the East Tobai â€“ Poreh Road Improvement project in Sokobanah District, the calculation results obtained were 20.32 m3/OH for foremen and 20.30 m3/OH for workers, while the 2022 AHSP Bina Marga calculations obtained results of 20.75 m3/OH for foremen and 32.27 m3/OH for workers. In general, the obstacles encountered in the implementation of the concrete road project in Sampang district during the tobacco growing season were the hot weather, labor motivation, and the distance of the cast supplier from the project work location.
Assessment of the Multipurpose Building of Sekolah Tinggi Teknologi Payakumbuh
Authors:   Program Studi Teknik Sipil, Sekolah Tinggi Teknologi Payakumbuh, Masdar Astuti , Wati Zuly Nelriska ,   Program Studi Teknik Sipil, Sekolah Tinggi Teknologi Payakumbuh, Khatab Umar ,   Program Studi Teknik Sipil, Sekolah Tinggi Teknologi Payakumbuh, Masdar Anita Dewi ,   Program Studi Teknik Sipil, Sekolah Tinggi Teknologi Payakumbuh, Noviarti Noviarti ,   Program Studi Teknik Sipil, Sekolah Tinggi Teknologi Payakumbuh
Published: January 2025

Sekolah Tinggi Teknologi Payakumbuh multi-purpose building is planned to have 3 floors with different functions on each floor. In the existing conditions this building still consists of 2 floors with the function of the 1st floor as a Civil Engineering Laboratory and the 2nd floor as a hall. The construction is carried out in stages and there are changes to the function of the building so that before continuing construction it is necessary to carry out an assessment to determine the impact of the conversion of the building on the feasibility of the multi-purpose building structure. The method used in this research is a quantitative method through visual assessment and technical assessment using testing equipment. Based on the results of the visual assessment, it was known that the categories of damage that occurred were structural and non-structural damage. Structural category II (minor) damage that occurs, namely fine cracks in several parts of the beam and stains on several beams, then non-structural Sek category I (minor) damage that occurs, namely fine cracks in several parts of the wall and stains in several parts of the wall . From the results of the technical assessment, namely the sondir results obtained the depth of hard soil is at a depth of 7 meters, while from the results of the Hammer Test obtained the average compressive strength for the structural components of the columns, beams and plates are fc' = 20.3 MPa, fc' = 20.7 MPa and fc' = 23.2 MPa respectively. The results of the building capacity analysis show that the construction cannot be continued to 3 floors considering that the building load for the 3-story condition exceeds the ability of the building capacity in the existing condition.
Early Invasive versus Conservative Strategies in Cardiogenic Shock: A Meta-Analysis
Authors: Ni Made Dharma Laksmi
Published: January 2025

Cardiogenic shock (CS) carries a high mortality rate. While early invasive strategies (EIS) like percutaneous coronary intervention (PCI) are often advocated, their superiority over conservative strategies (CS) remains debated. This meta-analysis compared the efficacy and safety of EIS versus CS in patients with CS. A systematic search of PubMed, Embase, and the Cochrane Library was conducted from January 2013 to December 2024. Randomized controlled trials (RCTs) and observational studies comparing EIS (early PCI, mechanical circulatory support) with CS (initial medical therapy) in adult CS patients were included. The primary outcome was all-cause mortality at 30 days. Secondary outcomes included in-hospital mortality, stroke, major bleeding, and acute kidney injury. A random-effects model was used to pool data. Nine studies (n=4,875 patients) were included. EIS was associated with a significantly lower risk of 30-day mortality compared to CS (risk ratio [RR] 0.78; 95% confidence interval [CI] 0.65-0.93; p=0.006). Similarly, EIS reduced in-hospital mortality (RR 0.72; 95% CI 0.61-0.85; p=0.001). There was no significant difference in the incidence of stroke or major bleeding between the two groups. However, EIS was associated with a higher risk of acute kidney injury (RR 1.20; 95% CI 1.05-1.37; p=0.008). In conclusion, in patients with CS, EIS was associated with significantly lower 30-day and in-hospital mortality compared to CS. However, EIS may increase the risk of acute kidney injury. Further research is needed to identify specific patient subgroups that may benefit most from EIS.
Techniques Used in Translation of Proverbs in Siku Njema by Ken Walibora
Authors: Benard Lilian Mumbi
Published: January 2025

Proverbs play a very important role in any cultural society such as to inform, caution, and inspire people in their daily lives, among others. Generation after generation, proverbs have endured, offering insights and direction that people still find meaningful to date. This research, is concentrating on the numerous approaches, which were employed by the translators Dorothy Kweyu and Fortunatus F. Kawegere to translate Siku Njema by Ken Walibora. This research highlights several approaches used in the translation process, including direct translation, equivalence, and omission, utilizing diverse methodologies such as the descriptive method which is utilized to explain each proverb, translating them from their original language to the target language while maintaining their contextual meaning. By taking this approach, the proverb's core meaning is maintained, enabling readers to completely understand its significance. The analytical method is also used, which allows for a greater comprehension of the complexity and cultural significance of each proverb. To capture details that could otherwise be lost in translation, this analysis is crucial. The comparative technique enhances the research even more and offers insights into how various cultures understand related issues by contrasting proverbs in their original form with their translated counterparts. Last but not least, the proverbs in "Siku Njema" are methodically chosen and examined using corpus analysis. In addition to aiding in the identification of important phrases, this approach makes it easier to comprehend how they are used throughout the text. The research intends to clarify the difficulties in communicating cultural meanings through language by looking at these different translation techniques, which will ultimately improve our understanding of the source material and its translation. This thorough examination highlights the proverbs' timeless value in fostering cross-cultural understanding and improving communication
Peningkatan Pemahaman Pengaplikasian M-Pajak berbasis Android dan iOS kepada Wajib Pajak bersama Relawan Pajak IBI Kosgoro 1957 Masa Bakti 2024 di Kecamatan Ciampea, Bogor Barat
Authors: Rahmadi Zara Tania , Yulianto Kampono Imam , Dharma Dias Adi , Putra Febryano Manggala , Wahyudi Muhammad Aria , Pemadi Syifa Febyca Nur , Rayan Rayan , Susetyawan Angellina Merry
Published: January 2025

Community devotionals in Ciampea, west bogor, aim to increase the understanding and application of android based m-tax applications and ios among taxpayers. On Saturday, April 27, 2024, with the participation of 20 taxpayers. Socialization includes the introduction of applications features such as billing code, billing profile Settings, and the location of nearby tax services, while fellowmen provide tutorials to make accounts, generate billing codes, and make tax payments online. It is expected to increase the efficiency of tax reporting and active engagement of taxpayers in the tax process in Indonesia.
Carcinogenic and non-carcinogenic human health risk assessment of some vegetables irrigated with wastewater in Jos, Plateau State, Nigeria
Authors: Bawa Usman , AbdulHameed Ahmad
Published: January 2025

Aim: There is growing concern on the use of contaminated and untreated water from industrial discharge for irrigation during the dry season farming in many parts of northern Nigeria. Industries effluents are among the major sources of heavy metal pollution of water bodies and when used for irrigation could be a source of heavy metal bioaccumulation in crops. This study determined the potential non-carcinogenic and carcinogenic health risks in both children and adults through the consumption of some vegetables irrigated with polluted water in Bassa, Plateau, and Nigeria. Methods: Four vegetable farms that exclusively use untreated industrial effluents were identified and eight commonly consumed vegetables were sampled for heavy metal analysis using atomic absorption spectrometry. The metals of interest were Cd, Pb, Cr, Cu, and Zn. Results: Concentrations of Cd, Pb, and Cr in all the vegetables exceeded the WHO’s permissible limits while Cu and Zn did not. Mean heavy metals in the vegetables ranged from 26.87–33.50 mg/kg (Cd), 4.17–10.90 mg/kg (Pb), 27.00–38.67 mg/kg (Cr), 10.60–24.38 mg/kg (Cu), and 1.77–3.42 mg/kg (Zn). Estimated daily intake (EDI) for Cd and Pb for both children and adults exceeded the oral risk-free dose (RFD) set by US-EPA. However, the EDI of Cu in children exceeds the RFD while the EDI of adults did not exceed RFD. Consumption of all the metal-contaminated vegetables posed a potential non cancer risk hazard index (HI ≥ 1) in both children and adults while the target cancer risks (TCR) were due to ingestion of Cd and Cr in the vegetables with TCR values above 1 × 10–4. Conclusions: This study found that adults and children population in this area are susceptible to non cancer and cancer health risks from the consumption of all the studied vegetables. Screening of industrial effluent should be prioritized and enforced to avoid crop heavy metal bioaccumulation.
Study of the fractional composition and xylanolytic activity of proteins produced by bacteria isolated from lignocellulosic biomass
Authors: Dyshlyuk Lyubov Sergeevna , Ulrikh Elena Victorovna , Agafonova Svetlana Victorovna , Kazimirchenko Oksana Vladimirovna
Published: January 2025

Introduction: In recent years, natural bioactive compounds have become a leading trend in the food and nutraceutical industries due to the diversity of their chemical structures and functions, as well as their positive effects on human health. The most studied and used bioactive compounds include prebiotics. Xylooligosaccharides, obtained by enzymatic hydrolysis of xylan, are of particular interest among prebiotics. Screening of microorganisms isolated from lignocellulosic raw materials for their ability to produce xylanolytic enzymes seems promising.

Purpose: To assess the fractional composition and xylanolytic activity of proteins produced by bacteria isolated from lignocellulosic raw materials of the Kaliningrad region – white lupine seeds.

Materials and Methods: Isolation of proteins from the fermentation medium and their fractionation were carried out using preparative HPLC. The molecular weight of protein fractions was determined by electrophoresis.

Results: 4 protein fractions were isolated from the culture fluid of bacteria of the genus Bacillus and their molecular masses were established, ranging from 35.60 to 246.10 kDa. It was shown that fraction No. 1 contains the largest amount of proteins with molecular weights of 242.30 kDa, 83.70 kDa and 35.90 kDa. It was revealed that in fraction No. 2 proteins with a molecular weight of 51.50 kDa (content was 63.60%) and 42.70 kDa (content was 18.30%) predominated. It was established that fraction No. 3 contains a large number of proteins with different molecular weights, fraction No. 4 contains proteins with molecular weights from 61.80 to 69.30 kDa, while the share of proteins with molecular weights of 69.30 kDa and 61.80 kDa accounting for 42.10 and 41.10%, respectively. It was revealed that proteins with molecular weights from 35.60 to 41.00 kDa have xylanolytic activity at a level of 107.33 units/g.

Conclusions: A scheme for the isolation of proteins with xylanolytic activity from the culture fluid of Bacillus megaterium bacteria isolated from seeds of white lupin (Lupinus albus) has been developed. The obtained enzymes can be used in the transformation of agro-industrial waste to produce xylooligosaccharides.
Historical Aspects of Endometrial Cancer Staging, Transition to Molecular Classification (Literature Review)
Authors: Очиров Максим Олегович , Коломиец Лариса Александровна , Вторушин Сергей Владимирович , Жуйкова Лилия Дмитриевна , Чуруксаева Ольга Николаевна , Виллерт Алиса Борисовна , Трущук Юлия Михайловна , Мальцева Анастасия Алексеевна , Мамонова Татьяна Юрьевна
Published: January 2025

Определение стадии опухолевого процесса является важнейшим этапом в лечении пациенток со злокачественными заболеваниями, напрямую коррелирует с прогнозом и выбором специализированного лечения, облегчая при этом обмен информацией между медицинскими специалистами. Система стадирования должна обладать тремя основными характеристиками: она должна быть действенной, надежной и практичной. Существующая система стадирования (классификации) рака эндометрия разработана в 2009 г., является высоковоспроизводимой и не требует чрезмерных диагностических исследований. При этом в классификации имеется множество «серых зон», которые препятствуют обоснованному подбору необходимого лечения у пациенток, оказавшихся в них. Наиболее ярким примером является необходимость проведения лимфодиссекции при I клинической стадии рака эндометрия, где при промежуточном риске решение о её проведении остается на усмотрение лечащего врача. Для решения данной проблемы, попытки индивидуализировать лечение и стратифицировать риск развития рецидива, в последние годы широкое распространение получила молекулярная классификация. А в 2023 г. Международная федерация акушеров-гинекологов предложила для использования новую систему стадирования рака эндометрия. Текущий обзор посвящен историческим аспектам эволюции представления о системной оценке рака эндометрия, и позволяет лучше оценить последние достижения в понимании биологии опухолей эндометрия.
The Prospects for the Targeted Therapy of KRAS-Mutated Lung Cancer
Authors: Муртазин Азат Инзирович , Алексахина Светлана Николаевна , Шестакова Анна Дмитриевна , Левченко Евгений Владимирович , Имянитов Евгений Наумович
Published: January 2025

Мутации в гене KRAS наблюдаются примерно в 15-30 % аденокарцином лёгкого. Активация KRAS приводит к стимуляции сигнального каскада MAPK, и, конечном счёте, к неконтролируемой пролиферации опухолевых клеток. В то время как применение терапевтических ингибиторов мутированных киназ, например, EGFR и BRAF, привело к революции в лечении онкологических заболеваний, разработка антагонистов активированного KRAS столкнулась со значительными трудностями. К настоящему моменту специфические ингибиторы мутированного KRAS разработаны только для замены глицина на цистеин в 12 кодоне данного гена (KRAS G12C). Эта мутация, в отличие от многих других разновидностей повреждений генов семейства RAS в опухолях лёгкого, наблюдается преимущественно у курильщиков, и, как следствие, ассоциирована с высокой мутационной нагрузкой и чувствительностью карцином к иммунотерапии. Клинические испытания ингибиторов KRAS(G12C), препаратов соторасиб и адаграсиб, проводились преимущественно в отношении пациентов с раком лёгкого, которые уже получали химиотерапию и ингибиторы контрольных точек иммунного ответа. Несмотря на относительно высокую частоту случаев контроля заболевания, медиана времени до прогрессирования измерялась всего несколькими месяцами. Рандомизированное сопоставление соторасиба и доцетаксела не продемонстрировало различий в общей продолжительности жизни пациентов. Эти данные значительно контрастируют с результатами успешных клинических испытаний ингибиторов других мутированных онкобелков. Осуществляется поиск «универсальных» препаратов, которые могут воздействовать на опухоли со всеми разновидностями мутаций генов семейства RAS. Результаты использования ингибиторов фарнезилтрансфераз, участвующих в пост-трансляционной модификации белков RAS, оказались неудачными в связи с запуском альтернативных механизмов этого процесса. Попытки воздействия на мишени RAS, в частности, киназу MEK, также оказались безуспешными, хотя в отдельных клинических наблюдениях продемонстрирована перспективность добавления к подобным схемам терапевтических ингибиторов аутофагии. Несмотря на перечисленные выше ограничения, анализ статуса ген RAS продолжает оставаться значимым компонентом обследования пациентов с раком лёгкого, так как обнаружение мутации в одном из генов данного семейства позволяет убедительно исключить наличие активирующих событий в киназах EGFR, ALK, ROS1, NTRK1-3, RET, MET, BRAF и HER2.
Cryoablation in the Treatment of Onco-urology Patients with Oligometastatic Bone Lesions
Authors: Прохоров Георгий Георгиевич , Буровик Илья Александрович , Носов Александр Константинович , Прохоров Денис Георгиевич , Щекутеев Никита Андреевич , Беркут Мария Владимировна
Published: January 2025

Введение. Частота олигометастатического поражения костей скелета в онкоурологии может варьировать в зависимости от типа рака и стадии заболевания: при раке предстательной железы и почки олигометастазы в кости скелета могут быть обнаружены у 20-30 % пациентов при первичном обращении и гораздо реже при уротелиальном раке. Паллиативное применение метастаз-направленной терапии в виде чрескожной криоаблации олигометастазов направлено на контроль болевого синдрома и улучшение качества жизни пациентов.
Цель. Изучение влияния миниинвазивной чрескожной криоаблации, выполняемой в условиях КТ-навигации, на уровень болевого синдрома у больных онкоурологического профиля с олигометастатическим поражением костей.
Материалы и методы. За период с 2019 по 2023 гг. в НМИЦ онкологии им. Н.Н. Петрова проведена чрескожная криоаблация костных олигометастазов у 27 пациентов при прогрессировании рака предстательной железы, почки и мочевого пузыря. Показаниями к операции рассматривали возможность достижения полной циторедукции единичных клинически значимых метастазов костей скелета (олигометастаз) и/или наличие некупируемого болевого синдрома вследствие вовлечения или сдавления нервных стволов с расстройствами чувствительности и движений. Процедуру мини-инвазивной чрескожной пункционной стереотаксической криоаблации выполняли в условиях КТ-навигации под наркозом с использованием Российской мини-инвазивной криохирургической системой «МКС» под контролем КТ- визуализации и прямой термометрии зоны охлаждения.
Результаты. Контрольное обследования 20 (74,0 %) пациентов через один год после метастаз-направленной терапии показало полную девитализацию соответствующих метастатических очагов. У пяти пациентов были выполнены повторные процедуры последовательно по мере появления метахронных метастазов. Качество жизни больных на протяжении всего периода наблюдения оставалось удовлетворительным. У семи пациентов после паллиативной противоболевой криоаблации с исходной болью на уровне 4–8 баллов по визуальной аналоговой шкале болевой синдром был купирован полностью, у остальных существенно снизился.
Выводы. Мини-инвазивная стереотаксическая криоаблация позволяет девитализировать внутрикостные очаги и может рассматриваться в качестве паллиативного лечения больных онкоурологического профиля для устранения локального болевого синдрома при олигометастазах.
Evaluation of the Efficacy of Second-Line Therapy for Metastatic Gastric Cancer in Real Clinical Practice - the Results of a Multicenter Retrospective Study: Experience of Moscow Oncology Service
Authors: Семёнов Николай Николаевич , Федянин Михаил Юрьевич , Хатьков Игорь Евгеньевич , Жукова Людмила Григорьевна , Строяковский Даниил Львович , Покатаев Илья Анатольевич
Published: January 2025

Введение. В настоящее время во II линии лечения метастатического рака желудка используются различные комбинации лекарственных препаратов.
Цель. Сравнить выживаемость без прогрессирования (ВБП) и общую выживаемость (ОВ) у пациентов метастатическим раком желудка, получавших различные варианты терапии во II линии лечения.
Материалы и методы. Из регистра Москвы выделено 384 пациента с морфологически подтвержденным метастатическим раком желудка, у которых было зафиксировано прогрессирование на фоне проведения I линии лечения. Сформированы 3 группы: получавшие терапию ингибиторами контрольных точек иммунитета (ИКТ) (n = 93), химиотерапию (х/т) (n = 82) и химиотерапию + рамуцирумаб (х/т + раму) (n = 208). Лечение проводилось с 2018 по 2023 гг. Медиана времени наблюдения составила 35,8 мес.
Результаты. В общей группе отмечено преимущество по ВБП у больных, получавших ИКТ и х/т + раму (4,3 мес. и 5,1 мес. соответственно), по сравнению с группой х/т (4,0 мес., р = 0,019 и 0,056 соответственно). ОВ во всех трех группах не различалась (ИКТ — 8,5 мес., х/т — 10,1 мес., х/т + раму — 10,7 мес., р = 0,4 и 0,43, в сравнении с группой х/т). Уровень CPS не влиял на эффективности в группе ИКТ (ВБП при CPS 0-9 — 3,9 мес. при CPS≥10 — 4,2 мес., р = 0,61; ОВ 6,6 мес. и 6,9 мес. соответственно, р = 0,875). При наличии MSI (n = 27) в группе ИКТ в сравнении с MSS ВБП была 11,1 мес. против 3,9 мес., р = 0,068, ОВ — 14,2 мес. против 5,4 мес., р = 0,162. При сравнении с больными с MSI, получавших х/т + раму (n = 14) эти различия нивелировались (ВБП — 11,1 мес. и 3,8 мес., р = 0,13, ОВ — 14,2 мес. и 16,0 мес., р = 0,75). В группах х/т + раму использование двух цитостатиков в сравнении с монотерапией улучшало ВБП, но не ОВ (ВБП — 5,8 мес. и 4,0 мес., р = 0,009, ОВ — 10,8 и 10,1 мес., р = 0,79). При проведении псевдорандомизации отмечено сохранение результатов, полученных в общей группе.
Выводы. Дублетные комбинации, добавление рамуцирумаба или использование ИКТ не продемонстрировали улучшение результатов в сравнении с монохимиотерапией.
Clinical Case: Percutaneous Translumbar Puncture and Embolization of Lymphatic Ducts under the Control of Flat-Detector Computed Tomography (FDCT) — an Effective Method for the Treatment of Lymphorrhea after Retroperitoneal Lymphadenectomy
Authors: Мамижев Эльдар Мухамедович , Балахнин Павел Васильевич , Румянцева Дарья Игоревна , Малькевич Василий Игоревич , Носов Александр Константинович
Published: January 2025

Интранодальная лимфангиография с чрескожной лимфатической эмболизацией является на сегодняшний день перспективным методом лечения обильной послеоперационной лимфореи. Нами приведено два успешных клинических случая лечения хилёзного асцита у пациентов после забрюшинной лимфаденэктомии по поводу герминогенной опухоли яичка. В обоих случаях достигнуто стойкое купирование осложнения со значительным улучшением качества жизни пациентов.
The fundamentals of eye tracking part 3: How to choose an eye tracker
Authors: Nyström Marcus , Hooge Ignace T. C. , Hessels Roy S. , Andersson Richard , Hansen Dan Witzner , Johansson Roger , Niehorster Diederick C.
Published: January 2025

There is an abundance of commercial and open-source eye trackers available for researchers interested in gaze and eye movements. Which aspects should be considered when choosing an eye tracker? The paper describes what distinguishes different types of eye trackers, their suitability for different types of research questions, and highlights questions researchers should ask themselves to make an informed choice.
POLITICAL TOPOGRAPHY OF THE REVOLUTIONARY HELSINGFORS IN THE SPRING OF 1917
Authors: Dubrovskaya Elena
Published: January 2025

The article continues the previously begun study of the political topography of the Finnish capital Helsingfors (Helsinki) in the first months of the Russian Revolution 1917. Based on the materials of Russian and Finnish archives, on published sources, the author shows how the boundaries between «own» and «alien», established
in the first days of the revolution, lost force over time and turned out to be blurred. The semantics of delimiting
the «mastered» and «undeveloped» space and «scolding» the morally obsolete symbols of the tsarist army (cutting shoulder straps and their demonstrative overthrow on the pavement, similar to the motif "trampling broken chains" popular in poster symbols) can be traced. It was concluded that in the context of the first revolutionary months
in the army and navy, the symbols of the former power were transformed and replaced by new ones. Joint with Finnish workers, the passage through the streets and squares of the city served to restore broken ties within the community of sailors and army men in the face of a hostile external world, and also demonstrated a refusal to oppose ethnic groups of local population and servicemen.
Pengembangan LKPD Asam Basa Berbasis Problem Based Learning Terintegrasi Culturally Responsive Teaching untuk Fase F SMA
Authors: Azka Hanifa  , Andromeda Andromeda
Published: January 2025

Tujuan pengajaran kimia di sekolah menengah atas adalah agar membekali para siswa dengan pengetahuan serta kemampuan praktis. Namun, pelaksanaannya masih menghadapi tantangan, terutama minimnya penggunaan LKPD yang disusun dengan kontekstual serta berbasis budaya. Penelitian ini bertujuan untuk membuat LKPD asam-basa berbasis PBL yang dikombinasikan dengan Pengajaran Responsif Budaya (CRT) untuk mengatasi masalah ini. Model PBL mendukung peserta didik memecahkan masalah nyata, sementara CRT mengaitkan pembelajaran dengan budaya lokal. Jenis penelitian yang dipakai ialah Educational Design Research (EDR) menggunakan moda pengembangan Plomp, meliputi tahapan pendahuluan, membentuk prototipe, serta penilaian. Dalam penelitian berikut hanya dibatas hingga tahapan pengembangan prototipe, yakni pada uji praktikalitas produk yang telah dikembangkan. Instrumen penelitian yang diterapkan meliputi uji validitas serta uji praktikalitas. Validitas LKPD dinilai memakai skala Aiken’s V, dengan melibatkan lima validator yang tersusun atas dosen dan guru kimia. Hasil uji validitas membuktikkan nilai rata-rata sebesar 0,86, yang termasuk dalam kategori valid. Sementara itu, praktikalitas diuji melalui angket yang melibatkan dua guru kimia serta sembilan siswa. Hasil uji membuktikkan tingkat kepraktisan sebesar 96% (sangat praktis) berlandaskan penilaian pendidik serta 83% (praktis) berdasarkan penilaian peserta didik, dengan mempertimbangkan aspek mudahnya pemakaian, daya tarik, efisiensi, dan manfaat pembelajaran. Perolehan penelitian membuktikkan bahwasannya LKPD asam-basa berbasis PBL terintegrasi CRT valid serta praktis diterapkan pada pembelajaran kimia. Penelitian berikut memberikan solusi inovatif untuk menciptakan pembelajaran kimia yang makin kontekstual, berarti, serta sesuai pada keseharian siswa, khususnya dalam materi asam-basa di SMA.
ANALISIS PENANGANAN KREDIT MACET DALAM UPAYA MENGURANGI TINGGINYA NON PERFORMANCE LOAN (Studi kasus PT Bank Rakyat Indonesia (Persero) Tbk unit Sekupang)
Authors: Leony Leony , Satriawan Bambang , Dewi Nolla Puspita
Published: January 2025

The problem that occurred was that the average Non-Performing Loan (NPL) ratio of the Sekupang Unit was one of the Units with the highest NPL percentage compared to other work units with a value of 55.31%. Non-performing loans arising from the distribution of working capital loans at PT Bank Rakyat Indonesia (Persero) Tbk Sekupang Unit are still quite high, therefore the Sekupang Unit must continue to strive to anticipate the occurrence of non-performing loans in the future. To anticipate the emergence of non-performing loans, banks must be careful in analyzing the feasibility of prospective debtors' businesses before working capital loans are distributed. This study uses a qualitative method by conducting interviews with 3 sources, heads of bank units and officers who are closely related to credit problems. The results of the study found that the factors causing the occurrence of non-performing loans at Bank BRI Sekupang Unit were 2 factors, namely internal and external factors. Internal factors are caused by the customer themselves who have bad intentions not to pay off the installment obligations. External factors are factors that occur because they are beyond the control of the customer. Handling of bad debts carried out by Bank BRI Sekupang Unit is by restructuring credit, a proactive approach and strict monitoring, collaboration with the collection and legal team, selling repossessed assets (AYDA), strengthening credit policies, training and education of staff, credit recovery programs, providing incentives for quick settlement, strengthening relationships with customers.