bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovering ‘what works’
Authors: Curran Helen
Published: April 2021

Fuelled by the pandemic, a stronger focus on communication is helping SENCOs to ensure that all children's needs are met and that colleagues share their expertise.
Pack up your worries
Authors: Burch Victoria
Published: April 2021

Addressing childhood fears and stresses is currently a priority for schools and early years settings. Victoria Burch gives her view on how resources developed by Act International, a charity dealing with childhood trauma, can help.
Bogged down
Authors: White Hilary
Published: April 2021

In the first of a new series exploring ecosystems in the context of sustainability, Hilary White focuses on wetlands and ponds with ideas for activities which will help children to understand their characteristics and wildlife.
At their command
Authors: Hewson Claire
Published: April 2021

While technology is not specifically covered in the revised EYFS it will feature in many everyday activities in your provision. In this first of a new series, Claire Hewson links Ipads and Bee-Bots to learning co-operatively.
Revisors del número
Authors: Gresa Barbero Deva
Published: April 2021

Revisors del número.
La integració audiovisual en infants amb trastorn del desenvolupament del llenguatge (TDL): on miren quan se’ls parla?
Authors: Ferinu Laura , Ahufinger Nadia , Sanz-Torrent Mònica , Andreu Llorenç
Published: April 2021

El trastorn del desenvolupament del llenguatge (TDL) es defineix com una afectació en l’adquisició i en el desenvolupament del llenguatge oral. Per poder adquirir adequadament el llenguatge oral, els infants han d’integrar la informació multimodal de la parla (auditiva i visual). Diferents estudis indiquen que aquests infants podrien presentar un dèficit per processar, gestionar i combinar la informació auditiva i visual, que podria generar dificultats fonològiques i d’adquisició del lèxic. Altres investigacions han mostrat que els infants amb TDL presenten un patró d’atenció focalitzada cap als ulls i la boca de l’interlocutor diferent al dels infants amb desenvolupament típic del llenguatge. El patró de mirada dels infants amb TDL sol ser més dispers, ja que es beneficien menys de les pistes audiovisuals i dediquen menys atenció als ulls i a la boca en comparació amb els infants amb desenvolupament típic.
Automated defect identification from carrier fringe patterns using Wigner–Ville distribution and a machine learning-based method
Authors: Vishnoi Ankur , Madipadaga Aditya , Ajithaprasad Sreeprasad , Gannavarpu Rajshekhar
Published: April 2021

The paper presents a method for automated defect identification from fringe patterns. The method relies on computing the fringe signal’s Wigner–Ville distribution followed by a supervised machine learning algorithm. Our machine learning approach enables robust detection of fringe pattern defects of varied shapes and alleviates the limitations associated with thresholding-based techniques that require careful control of the threshold parameter. The potential of the proposed method is demonstrated via numerical simulations to identify different types of defect patterns at various noise levels. In addition, the practical applicability of the method is validated by experimental results.
Zika virus dysregulates the expression of astrocytic genes involved in neurodevelopment
Authors: Shereen Muhammad Adnan , Bashir Nadia , Su Rui , Liu Fang , Wu Kailang , Luo Zhen , Wu Jianguo
Published: April 2021

Zika virus (ZIKV) is a kind of flavivirus emerged in French Polynesia and Brazil, and has led to a worldwide public health concern since 2016. ZIKV infection causes various neurological conditions, which are associated with fetus brain development or peripheral and central nervous systems (PNS/CNS) functional problems. To date, no vaccine or any specific antiviral therapy against ZIKV infection are available. It urgently needs efforts to explore the underlying molecular mechanisms of ZIKV-induced neural pathogenesis. ZIKV favorably infects neural and glial cells specifically astrocytes, consequently dysregulating gene expression and pathways with impairment of process neural cells. In this study, we applied a model for ZIKV replication in mouse primary astrocytes (MPAs) and profiled temporal alterations in the host transcriptomes upon ZIKV infection. Among the RNA-sequencing data of 27,812 genes, we examined 710 genes were significantly differentially expressed by ZIKV, which lead to dysregulation of numerous functions including neurons development and migration, glial cells differentiation, myelinations, astrocytes projection, neurogenesis, and brain development, along with multiple pathways including Hippo signaling pathway, tight junction, PI3K-Akt signaling pathway, and focal adhesion. Furthermore, we confirmed the dysregulation of the selected genes in MPAs and human astroglioma U251 cells. We found that PTBP1, LIF, GHR, and PTBP3 were upregulated while EDNRB and MBP were downregulated upon ZIKV infection. The current study highlights the ZIKV-mediated potential genes associated with neurodevelopment or related diseases.
The effect of a digital targeted client communication intervention on pregnant women’s worries and satisfaction with antenatal care in Palestine–A cluster randomized controlled trial
Authors: Bogale Binyam , Mørkrid Kjersti , Abbas Eatimad , Abu Ward Itimad , Anaya Firas , Ghanem Buthaina , Hijaz Taghreed , Isbeih Mervett , Issawi Sally , A. S. Nazzal Zaher , E. Qaddomi Sharif , Frøen J. Frederik
Published: April 2021

Background

The eRegCom cluster randomized controlled trial assesses the effectiveness of targeted client communication (TCC) via short message service (SMS) to pregnant women, from a digital maternal and child health registry (eRegistry) in Palestine, on improving attendance and quality of care. In this paper, we assess whether this TCC intervention could also have unintended consequences on pregnant women’s worries, and their satisfaction with antenatal care (ANC).

Methods

We interviewed a sub-sample of Arabic-speaking women attending ANC at public primary healthcare clinics, randomized to either the TCC intervention or no TCC (control) in the eRegCom trial, who were in 38 weeks of gestation and had a phone number registered in the eRegistry. Trained female data collectors interviewed women by phone from 67 intervention and 64 control clusters, after securing informed oral consent. The Arabic interview guide, pilot-tested prior to the data collection, included close-ended questions to capture the woman’s socio-demographic status, agreement questions about their satisfaction with ANC services, and the 13-item Cambridge Worry Scale (CWS). We employed a non-inferiority study design and an intention-to-treat analysis approach.

Results

A total of 454 women, 239 from the TCC intervention and 215 from the control arm participated in this sub-study. The mean and standard deviation of the CWS were 1.8 (1.9) for the intervention and 2.0 (1.9) for the control arm. The difference in mean between the intervention and control arms was -0.16 (95% CI: -0.31 to -0.01) after adjusting for clustering, which was below the predefined non-inferiority margin of 0.3. Women in both groups were equally satisfied with the ANC services they received.

Conclusion

The TCC intervention via SMS did not increase pregnancy-related worries among recipients. There was no difference in women’s satisfaction with the ANC services between intervention and control arms.
Evaluation of [Cys(ATTO 488)8]Dermorphin-NH2 as a novel tool for the study of μ-opioid peptide receptors
Authors: Giakomidi Despina , Bird Mark F. , McDonald John , Marzola Erika , Guerrini Remo , Chanoch Serena , Sabu Nidhuna , Horley Barbara , Calo Girolamo , Lambert David G.
Published: April 2021

The μ-opioid peptide (MOP) receptor is a member of the opioid receptor family and an important clinical target for analgesia. Measuring MOP receptor location and tracking its turnover traditionally used radiolabels or antibodies with attendant problems of utility of radiolabels in whole cells and poor antibody selectivity. To address these issues we have synthesized and characterised a novel ATTO488 based fluorescent Dermorphin analogue; [Cys(ATTO 488)8]Dermorphin-NH2 (DermATTO488). We initially assessed the binding profile of DermATTO488 in HEK cells expressing human MOP and CHO cells expressing human MOP, δ-opioid peptide (DOP), κ-opioid peptide (KOP) and Nociceptin/Orphanin FQ peptide (NOP) receptors using radioligand binding. Functional activity of the conjugated peptide was assessed by measuring (i) the ability of the ligand to engage G-protein by measuring the ability to stimulate GTPγ[35S] binding and (ii) the ability to stimulate phosphorylation of ERK1/2. Receptor location was visualised using confocal scanning laser microscopy. Dermorphin and DermATTO488 bound to HEKMOP (pKi: 8.29 and 7.00; p<0.05), CHOMOP (pKi: 9.26 and 8.12; p<0.05) and CHODOP (pKi: 7.03 and 7.16; p>0.05). Both ligands were inactive at KOP and NOP. Dermorphin and DermATTO488 stimulated the binding of GTPγ[35S] with similar pEC50 (7.84 and 7.62; p>0.05) and Emax (1.52 and 1.34fold p>0.05) values. Moreover, Dermorphin and DermATTO488 produced a monophasic stimulation of ERK1/2 phosphorylation peaking at 5mins (6.98 and 7.64-fold; p>0.05). Finally, in confocal microscopy DermATTO488 bound to recombinant MOP receptors on CHO and HEK cells in a concentration dependent manner that could be blocked by pre-incubation with unlabelled Dermorphin or Naloxone. Collectively, addition to ATTO488 to Dermorphin produced a ligand not dissimilar to Dermorphin; with ~10fold selectivity over DOP. This new ligand DermATTO488 retained functional activity and could be used to visualise MOP receptor location.
Soliciting organ donations by medical personnel and organ donation coordinators: A factor analysis
Authors: Chuang Yao-Mei , Yeh Shan-Shan , Tseng Chi-Fen , Tseng Chie-Chien
Published: April 2021

The literature on organ donation in Taiwan lacks a discussion of the roles of medical staff, organ donors, and transplant coordinators in organ donation. The biggest plight of organ donation is lack of the organ donations. When we probed the possibilities of not finish the organ donation procedure, such as religions, traditions and cultural belief, disease cognitions, and the failure of persuasion or the loss of organ donors. There are lots of research literature shown that the attitude of medical personnel would influence the willingness of organ donation or persuasion. This study considered such personnel and their participation in organ donation, specifically analyzing factors influencing their effectiveness. Snowball sampling was adopted to recruit medical staff, organ donors, and transplant coordinators for an online survey. The results revealed that some participants were unclear as to how to initiate the organ donation process and what practical operations are involved. Even with the necessary qualifications, some participants remained passive when soliciting organ donations in clinical practice. Organ donation coordinators with experience in caring for organ donors who attended organ donation courses performed well in soliciting organ donations. The researchers recommend that training courses on clinical planning and organ donation are incorporated into intensive care training and that they serve as the basis for counsellors soliciting organ donations to increase nurses’ willingness to solicit organ donations.
Mental health disorders research in the countries of the Organisation of Islamic Cooperation (OIC), 2008–17, and the disease burden: Bibliometric study
Authors: Lewison Grant , Sullivan Richard , Kiliç Cengiz
Published: April 2021

The 57 countries of the Organisation of Islamic Cooperation are suffering from an increasing burden from mental health disorders. We investigated their research outputs during 2008–17 in the Web of Science in order to compare them with the burden from different mental health disorders and in different countries. The papers were identified with a complex filter based on title words and journals. Their addresses were parsed to give fractional country counts, show international collaboration, and also reveal country concentration on individual disorders and types of research. We found 17,920 papers in the decade, with output quadrupling. Foreign contributions accounted for 15% of addresses; they were from Europe (7%), Canada + USA (5%) and elsewhere (3%). They were much greater for Qatar and Uganda (> 60%), but less than 10% for Iran and Turkey. Schizophrenia and bipolar disorder were over-researched, but suicide and self-harm were seriously neglected, relative to their mental health disorder burdens. Although OIC research has been expanding rapidly, some countries have published little on this subject, perhaps because of stigma. Turkey collaborates relatively little internationally and as a result its papers received few citations. Among the large OIC countries, it has almost the highest relative mental health disorders burden, which is also growing rapidly.
A novel approach to dry weight adjustments for dialysis patients using machine learning
Authors: Kim Hae Ri , Bae Hong Jin , Jeon Jae Wan , Ham Young Rok , Na Ki Ryang , Lee Kang Wook , Hyon Yun Kyong , Choi Dae Eun
Published: April 2021

Background and aims

Knowledge of the proper dry weight plays a critical role in the efficiency of dialysis and the survival of hemodialysis patients. Recently, bioimpedance spectroscopy(BIS) has been widely used for set dry weight in hemodialysis patients. However, BIS is often misrepresented in clinical healthy weight. In this study, we tried to predict the clinically proper dry weight (DWCP) using machine learning for patient’s clinical information including BIS. We then analyze the factors that influence the prediction of the clinical dry weight.

Methods

As a retrospective, single center study, data of 1672 hemodialysis patients were reviewed. DWCPdata were collected when the dry weight was measured using the BIS (DWBIS). The gap between the two (GapDW) was calculated and then grouped and analyzed based on gaps of 1 kg and 2 kg.

Results

Based on the gap between DWBISand DWCP, 972, 303, and 384 patients were placed in groups with gaps of <1 kg, ≧1kg and <2 kg, and ≧2 kg, respectively. For less than 1 kg and 2 kg of GapDW, It can be seen that the average accuracies for the two groups are 83% and 72%, respectively, in usign XGBoost machine learning. As GapDWincreases, it is more difficult to predict the target property. As GapDWincrease, the mean values of hemoglobin, total protein, serum albumin, creatinine, phosphorus, potassium, and the fat tissue index tended to decrease. However, the height, total body water, extracellular water (ECW), and ECW to intracellular water ratio tended to increase.

Conclusions

Machine learning made it slightly easier to predict DWCPbased on DWBISunder limited conditions and gave better insights into predicting DWCP. Malnutrition-related factors and ECW were important in reflecting the differences between DWBISand DWCP.
A high throughput reporter virus particle microneutralization assay for quantitation of Zika virus neutralizing antibodies in multiple species
Authors: Bohning Kelly , Sonnberg Stephanie , Chen Hui-Ling , Zahralban-Steele Melissa , Powell Timothy , Hather Greg , Patel Hetal K. , Dean Hansi J.
Published: April 2021

Zika virus is a Flavivirus, transmitted viaAedesmosquitos, that causes a range of symptoms including Zika congenital syndrome. Zika has posed a challenging situation for health, public and economic sectors of affected countries. To quantitate Zika virus neutralizing antibody titers in serum samples, we developed a high throughput plate based Zika virus reporter virus particle (RVP) assay that uses an infective, non-replicating particle encoding Zika virus surface proteins and capsid (CprME) and a reporter gene (Renillaluciferase). This is the first characterization of a Zika virus RVP assay in 384-well format using a Dengue repliconRenillareporter construct. Serially diluted test sera were incubated with RVPs, followed by incubation with Vero cells. RVPs that have not been neutralized by antibodies in the test sera entered the cells and expressedRenillaluciferase. Quantitative measurements of neutralizing activity were determined using a plate-based assay and commercially available substrate. The principle of limiting the infection to a single round increases the precision of the assay measurements. RVP log10EC50titers correlated closely with titers determined using a plaque reduction neutralization test (PRNT) (R2>95%). The plate-based Zika virus RVP assay also demonstrated high levels of precision, reproducibility and throughput. The assay employs identical reagents for human, rhesus macaque and mouse serum matrices. Spiking studies indicated that the assay performs equally well in different species, producing comparable titers irrespective of the serum species. The assay is conducted in 384-well plates and can be automated to simultaneously achieve high throughput and high reproducibility.
Understanding the impact of high-risk human papillomavirus on oropharyngeal squamous cell carcinomas in Taiwan: A retrospective cohort study
Authors: Lorenzatti Hiles Guadalupe , Chang Kai-Ping , Bellile Emily L. , Wang Chun-I , Yen Wei-Chen , Goudsmit Christine M. , Briggs Hannah L. , Thomas Trey B. , Peters Lila , Afsari Macy A. , Pinatti Lisa M. , Morris Anna C. , Jawad Nadine , Carey Thomas E. , Walline Heather M.
Published: April 2021

Background and objectives

Human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) is increasing globally. In Taiwan, HPV-positive OPSCC is obscured by tobacco, alcohol, and betel quid use. We investigated the role of high-risk HPV (hrHPV) in a large retrospective Taiwan OPSCC cohort.

Methods and results

The cohort of 541 OPSCCs treated at Chang Gung Memorial Hospital from 1998–2016 consisted of 507 men (94%) and 34 women (6%). Most used tobacco (81%), alcohol (51%), and betel quid (65%). Formalin-fixed, paraffin-embedded tissue was used for p16 staining (a surrogate marker for HPV) and testing for HPV DNA presence and type by Multiplex HPV PCR-MassArray. HPV DNA and/or p16 staining (HPV-positive) was found in 28.4% (150/528) tumors. p16 and HPV DNA were strongly correlated (F< 0.0001). HPV16 was present in 82.8%, and HPV58 in 7.5% of HPV-positive tumors. HPV was associated with higher age (55.5 vs. 52.7 years,p= 0.004), lower T-stage (p= 0.008) better overall survival (OS) (hazard ratio [HR] 0.58 [95% CI 0.42–0.81],p= 0.001), and disease-free survival (DFS) (HR 0.54 [95% CI 0.40–0.73],p< 0.0001). Alcohol was strongly associated with recurrence and death (OS: HR 2.06 [95% CI 1.54–2.74],p< 0.0001; DFS: HR 1.72 [95% CI 1.33–2.24],p< 0.0001). OS and DFS in HPV-positive cases decreased for alcohol users (p< 0.0001). Obscured by the strong alcohol effect, predictive associations were not found for tobacco or betel quid.

Conclusions

As with HPV-positive OPSCC globally, HPV is an increasingly important etiological factor in Taiwanese OPSCC. HPV-positive OPSCC has considerable survival benefit, but this is reduced by alcohol, tobacco, and betel quid use. hrHPV is a cancer risk factor in males and females. Vaccinating both sexes with a multivalent vaccine including HPV58, combined with alcohol and tobacco cessation policies will be effective cancer-prevention public health strategies in Taiwan.
Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy
Authors: Suk Kang Jeong , Son Seung Seob , Lee Ji-Hye , Lee Seong Woo , Jeong Ah Reum , Lee Eun Soo , Cha Seung-Kuy , Chung Choon Hee , Lee Eun Young
Published: April 2021

The anti-aging gene, klotho, has been identified as a multi-functional humoral factor and is implicated in multiple biological processes. However, the effects of klotho on podocyte injury in diabetic nephropathy are poorly understood. Thus, the current study aims to investigate the renoprotective effects of klotho against podocyte injury in diabetic nephropathy. We examined lipid accumulation and klotho expression in the kidneys of diabetic patients and animals. We stimulated cultured mouse podocytes with palmitate to induce lipotoxicity-mediated podocyte injury with or without recombinant klotho. Klotho level was decreased in podocytes of lipid-accumulated obese diabetic kidneys and palmitate-treated mouse podocytes. Palmitate-treated podocytes showed increased apoptosis, intracellular ROS, ER stress, inflammation, and fibrosis, and these were significantly attenuated by klotho administration. Klotho treatment restored palmitate-induced downregulation of the antioxidant molecules, Nrf2, Keap1, and SOD1. Klotho inhibited the phosphorylation of FOXO3a, promoted its nuclear translocation, and then upregulated MnSOD expression. In addition, klotho administration attenuated palmitate-induced cytoskeleton changes, decreased nephrin expression, and increased TRPC6 expression, eventually improving podocyte albumin permeability. These results suggest that klotho administration prevents palmitate-induced functional and morphological podocyte injuries, and this may indicate that klotho is a potential therapeutic agent for the treatment of podocyte injury in obese diabetic nephropathy.
Tweeter-in-chief: Rwandan president Paul Kagame’s use of Twitter
Authors: Cohen Meghan Sobel , McIntyre Karen
Published: April 2021

Rwanda has received international praise for its rapid development and is said to be undergoing a ‘technology revolution’ at the hands of President Paul Kagame who has been described as a ‘Digital President’. This quantitative content analysis of Kagame’s official Twitter account analysed the first ten years of his tweets and found that he primarily tweets in English, with a positive sentiment about cross-government and cross-border interactions and, in doing so, presents Rwanda as a progressive, democratic player that is connected multilaterally to both African and global affairs. Throughout the decade, Kagame’s tweets evolved from being domestically focused on self-promotion to more globally focused on foreign engagement. While these findings could be indicative of a semi-authoritarian state, they also point to the presence of ‘Twitter diplomacy’ and the use of soft power tactics, which become stronger and clearer in the latter part of the decade.
Convergence and divergence of ICTs in Egyptian newsrooms: A longitudinal approach
Authors: El Gody Ahmed
Published: April 2021

The convergence of information communication technologies (ICTs) in news-making processes has changed the nature of news production in post-Arab Spring Egypt. Several newsrooms have integrated ICTs into their daily routines to develop their content and reconnect with their audiences. Although on the surface this seems a positive development, it appears that today, just a few years after integrating ICTs, Egyptian newsrooms are lagging behind. This study examines the utilization of ICTs – especially social media – in three Egyptian newsrooms. Three waves of questionnaires in 2012, 2014/2015 and 2018 which constitute a longitudinal survey of ICT convergence across the three newsrooms. The questionnaires’ repetition of cross-sectional questions allowed the author to measure changes in newsrooms’ adoption of ICTs over this seven-year span. In short, this study measures how newsroom culture has changed in relation to ICTs, how newsroom management views ICTs and the growing role of social media in newsroom operations.
Ghost Story as Social Commentary: A Look at Mati Diop’s Atlantics
Authors: Hamzah Sahar
Published: April 2021

Review of: Ghost Story as Social Commentary: A Look at Mati Diop’s Atlantics

Atlantics, Mati Diop (dir.) (2019), France: Ad Vitam, France
Adalékok a hagyományos és az újszerű vállalatértékelési eljárások összehasonlításához
Authors: Geday Péter
Published: April 2021

A cikk a DCF és az EVA módszerek elemzésével, összehasonlításával foglalkozik. Bemutatja a DCF alapmodelljeit: az FCFE – Free Cash-Flow to Equity-t, amit a német irodalomban egyszerûen csak Equity módszernek is ismerhetünk –, valamint az FCFF – Free Cash-Flow to the Firm, vagy másképpen Entity – vállalatértékelési módszereket. Majd a következô lépésben megismerheti az olvasó az EVA modell lényegét, számítási módszertanát, végül pedig az FCFF és az EVA modell számszaki egyezôségének feltételeit vizsgálja a szerzô, illetve összehasonlítja a két eljárást egymással. Kutatásának alapgondolata ugyanis, hogy a két megközelítés egymásba vezethetô, illetve hogy a módszertani szempontból közös gyökerek ellenére több szempontból eltérô alkalmazási szituációk figyelhetők meg a két módszer kapcsán.
A vezetői döntéshozatal etikai konfliktusai (II. rész)
Authors: Barakonyi Károly
Published: April 2021

A stratégiai döntéshozó számára hasznos lehet, ha tisztában van az etikai konfliktusok természetével, veszélyességével, ha felkészül azok kezelésére és feloldására. A cikk az etika, ideológia, erkölcs fogalmainak áttekintése után az etikai konfliktusokkal, azok osztályozásával, majd a megoldás folyamataival foglalkozik.
REESTRUTURAÇÃO DO CAPITALISMO NO CONTEXTO DAS CIDADES MÉDIAS: REFLEXÕES EM TORNO DA PRECARIZAÇÃO DO TRABALHO EM MOSSORÓ-RN
Authors: Ferreira da Silva Cleiton , Smalley Soares Pereira Cláudio
Published: April 2021

As problematizações evidenciadas neste trabalho refletem as primeiras reflexões a partir de um projeto de pesquisa de maior envergadura que está sendo desenvolvido a respeito da fragmentação socioespacial e urbanização brasileira por um conjunto de pesquisadores no país, denominado “Fragmentação socioespacial e urbanização brasileira: escalas, vetores, ritmos e formas”. A ideia proposta aqui está centrada em refletir sobre a reestruturação produtiva e suas implicações sociais, econômicas e espaciais no contexto das cidades médias, analisando especialmente a cidade de Mossoró (uma das cidades integrantes do projeto). Buscamos investigar o impacto desta reestruturação, como resultado e condição de transformação do capitalismo e de modificações substanciais no contexto contemporâneo do mundo do trabalho, com características cada vez mais assentadas sob o funcionamento das tecnologias digitais, configurando o que vem sendo chamado de capitalismo de plataformas, que pode ser exemplificado com os serviços de aplicativos da empresa Bee na respectiva cidade. Empresa de capital local que vem se expandindo por diversas cidades do país através da lógica da “plataformização” e da precarização do trabalhador.
O PROCESSO DE INDUSTRIALIZAÇÃO BAIANO E SEUS IMPACTOS DEMOGRÁFICOS E OCUPACIONAIS NO MUNICÍPIO DE FEIRA DE SANTANA-BA
Authors: Silva Gesner Brehmer de Araújo , Oliveira Lima José Raimundo
Published: April 2021

Iniciado formalmente nos anos 1950 com a instalação do Centro Industrial do Aratu em Salvador, o processo de industrialização do estado da Bahia trouxe profundas transformações tanto na estrutura produtiva, quanto econômica no estado. Feira de Santana como segunda maior cidade do estado, não passou inócua a esse processo com a instalação do Centro Industrial do Subaé (CIS) na década de 1970. O propósito deste artigo é de analisar os impactos desse processo de industrialização no município de Feira de Santana sobre duas óticas: a demográfica e a ocupacional através de dados disponíveis no Instituto Brasileiro de Geografia e Estatística (IBGE). Como resultados obtidos, inferiu-se que após o processo de industrialização baiano e a instalação do CIS, há uma mudança demográfica no município que passa a concentrar maior população urbana e ocupacional no qual os setores industriais e de serviços passam a empregar uma maior força de trabalho.
VULNERABILIDADE SOCIOECONÔMICA DA CIDADE DE FORTALEZA AO COVID-19: O EPICENTRO DA PANDEMIA NA REGIÃO NORDESTE DO BRASIL
Authors: Façanha Câmara Samuel , Batista de Carvalho Hermano José , Gerhard Felipe , Roberto Felipe , De Paula Thiago Matheus
Published: April 2021

Esta pesquisa objetivou identificar a vulnerabilidade associada à saúde e às dimensões social e econômica dos moradores dos bairros de Fortaleza quanto à pandemia Covid-19. Em seus aspectos metodológicos, o estudo exploratório-descritivo de natureza quantitativa mensurou a vulnerabilidade dos bairros da cidade de Fortaleza em três etapas: i. Vulnerabilidade Ampla – constituída por vínculos empregatícios, renda anual e pobreza extrema presente em cada bairro; ii. Vulnerabilidade Territorial – formada por aspectos relacionados às esferas econômica e sociodemográfica; iii. Vulnerabilidade das condições de Saúde – constituída, além das vulnerabilidades anteriores, por fatores como oferta de serviços de saúde. Os resultados do mapeamento ressaltaram a divisão econômica e social presente em Fortaleza. Enquanto os bairros mais ricos se destacam na análise por apresentarem uma alta vulnerabilidade econômica, ligada à produção, os mais pobres se destacam pela alta vulnerabilidade social. Essa discrepância suscita a possibilidade de existência de duas crises pandêmicas distintas exigindo a formulação de estratégias completamente diferentes para impedir os seus avanços. Destaca-se, ademais, uma preocupação adicional relacionada ao combate da Covid-19 nas Zonas Especiais de Interesse Social, contextos sociais marcados pela pobreza e precariedade da estrutura pública.
EXPANSÃO URBANA DE SÃO MIGUEL/RN: ANÁLISE NO RECORTE TEMPORAL DE 2000 A 2017
Authors: De Freitas Lima Daniela , Mariano de Sousa Junior Almir , Do O' de Lima Júnior Francisco , Henrique Maciel de Queiroz José
Published: April 2021

O crescimento urbano brasileiro ocorreu mais intensivamente a partir do século XX, motivado especialmente pela industrialização e, a consequente migração do campesinato, isto é, foi a influência capitalista que consolidou a inversão urbano-rural que o país vivenciou a partir da década de 1970. O objetivo deste trabalho é analisar a expansão urbana do município São Miguel/RN mediante as dinâmicas territoriais a ele associadas. Para tanto, foram estudados dados sobre a população, economia, instrumentos de ordenamento territorial e loteamentos deste município no período de 2000 a 2017, obtidos por meio da coleta documental digital e em órgãos municipais; e de entrevistas com prefeito municipal, historiador e colunista, chefe do departamento de fiscalização de obras e com moradores de São Miguel/RN. Constatou-se que a expansão urbana recente da cidade de São Miguel/RN teve a influência de dinâmicas sociodemográficas, do crescimento do setor terciário, dos parcelamentos do solo urbano e dos direcionamentos existentes em legislação municipal.
ANALYSIS OF THE DEGREE OF GRASSLAND DEGRADATION USING REMOTE SENSING
Authors: Santos Motta Jaiza , Encina César Claudio Cáceres , Guaraldo Eliane , Gonçalves Ariadne Brabosa , Gamarra Roberto Macedo , Paranhos Filho Antonio Conceição
Published: April 2021

The objective of this study is to adapt the calculations of the Pasture Degradation Index (GDI) to the Brazilian savannah using medium spatial resolution satellite image for the dry season. Vegetation cover is the main evaluation parameter used to calculate the GDI. The extreme ranges of the grazing class were determined by the NDVI histogram of a single date. Pasture cover was distinguished into five classes called Vegetable Pasture Cover (GVC), derived from NDVI and compared with five other classes derived from field photographs, named Green Coverage Percentage (GCP). The similarity between GVC and GVP demonstrated that GVC can be used to classify pasture cover. As a product of GVC, GDI was obtained. The GDI showed that pasture degradation in Paraíso das Águas is very serious. Extremely severe and Severe degradation occupy 9.28% and 25.22% of the study area, moderate and light degradation of pasture occupy 8.29% and 4.50%, respectively, and the non-degradation area covers 1.43 % of pastures. The results suggest the possibility of applying the GDI, originally developed for natural fields and multitemporal remote sensing data, to evaluate the conditions of the tropical savanna planted fields by means of a unique image.
USO DE DADOS METEOROLÓGICOS DE REANÁLISE PARA A SIMULAÇÃO DA VAZÃO NA BACIA HIDROGRÁFICA DO RIBEIRÃO DO PINHAL, LIMEIRA/SP
Authors: Batista Alves João Carlos , Lopes Martins Letícia , Araújo Martins Wander , Leite de Moraes Jener Fernando , Constantino Blain Gabriel
Published: April 2021

A grande preocupação com a preservação dos recursos hídricos demanda estudos capazes de avaliar e mitigar os impactos decorrentes das ações antrópicas. O uso de modelos hidrológicos constitui-se numa ferramenta importante, pois permitem simular diferentes cenários e seus impactos na disponibilidade hídrica. No entanto, a complexidade de obter dados meteorológicos observados, torna necessária a utilização de outras fontes de dados.  Objetivou-se avaliar se com a utilização de dados meteorológicos de reanálise obtidos do modelo Climate Forecast System Reanalysis (CFSR) é possível calibrar o modelo Soil and Water Assessment Tool (SWAT) e simular a produção de água numa bacia hidrográfica. A área de estudo é a bacia hidrográfica do Ribeirão do Pinhal (BHRP), situada no município de Limeira-SP. Utilizou-se o modelo SWAT para simulação hidrológica com os dados meteorológicos observados e de reanálise. Foi possível calibrar o modelo SWAT utilizando os dados meteorológicos observados e de reanálise. Porém, o ajuste foi melhor quando se utilizou os dados meteorológicos observados. A vazão simulada utilizando dados de reanálise foi superestimada. Os dados meteorológicos de reanálise são adequados para simulações hidrológicas com o modelo SWAT, o que é evidenciado por meio dos índices estatísticos satisfatórios obtidos no procedimento de calibração do modelo SWAT.
Mediating role of strategic orientations in the relationship between entrepreneurial orientation and performance of Saudi SMEs
Authors: Abdulrab Mohammed , Al-Mamary Yaser Hasan Salem , Alwaheeb Mohammed A. , Alshammari Naif Ghazi M. , Balhareth Hamad , Al-Shammari Serhan A.
Published: April 2021

Goal: This study aims to examine the mediating role of strategic orientations in the relationship between entrepreneurial orientation and performance of small and medium enterprises (SMEs) in Saudi Arabia.

Design/Methodology/Approach: Quantitative analysis techniques is used in this study. Data from 206 KSA owners / managers of SMEs is obtained and analysed using Partial Least Squares Structural Equation Modelling (PLS-SEM).

Results: Findings indicate that strategic orientations mediate the relationship between entrepreneurial orientation and performance of SMEs in Saudi Arabia.

Limitations of the investigation: The proposed model may not be generalised and must be applied in other contexts and cultures.

Practical implications: This study indicates that KSA managers should maintain emphasis on entrepreneurship and establish unique strategic techniques to improve efficiency. Policymakers are recommended to establish entrepreneurship initiatives for SMEs to form entrepreneurship. Additional recommendations are also provided.

Originality / Value: This study adds to the current body of knowledge by addressing the mediating role of market and technology orientation in the relationship between entrepreneurial orientation and performance of Saudi SMEs.
Commodification or shared ownership? A case study of Chinese communities in the linguistic landscape of Bendigo
Authors: Yao Xiaofang
Published: April 2021

Current linguistic landscape studies of tourism are primarily concerned with the commodification of languages, and less attention is focused on ownership discourses that are constructed in tourist spaces through varied semiotic resources. This study employs a spatial perspective to analyse commodification and ownership in the linguistic landscape of Bendigo, Victoria, Australia, focusing on how these discourses materialise in the conceived, perceived, and lived spaces through the semiotic resources of Chinese communities. Built on a comprehensive dataset of photographs, field notes, interviews, and archived materials, this study reveals the agency of Bendigo’s Chinese community members, who claim ownership of semiotic resources despite the institutional forces seeking to commodify Chinese cultural heritage for tourist consumption. Examination of Chinese heritage sites demonstrates the possibility of shared ownership of Chinese semiotic resources among Chinese and non-Chinese residents in an Australian cultural tourism context. This balancing act of commodification and ownership constitutes a critical part of the lived experiences of Chinese communities in today’s era of mobility and globalisation.
Deep convolutional neural network for chronic kidney disease prediction using ultrasound imaging
Authors: Patil Smitha , Choudhary Savita
Published: April 2021

Objectives

Chronic kidney disease (CKD) is a common disease and it is related to a higher risk of cardiovascular disease and end-stage renal disease that can be prevented by the earlier recognition and diagnosis of individuals at risk. Even though risk factors for CKD have been recognized, the effectiveness of CKD risk classification via prediction models remains uncertain. This paper intends to introduce a new predictive model for CKD using US image.

Methods

The proposed model includes three main phases “(1) preprocessing, (2) feature extraction, (3) and classification.” In the first phase, the input image is subjected to preprocessing, which deploys image inpainting and median filtering processes. After preprocessing, feature extraction takes place under four cases; (a) texture analysis to detect the characteristics of texture, (b) proposed high-level feature enabled local binary pattern (LBP) extraction, (c) area based feature extraction, and (d) mean intensity based feature extraction. These extracted features are then subjected for classification, where “optimized deep convolutional neural network (DCNN)” is used. In order to make the prediction more accurate, the weight and the activation function of DCNN are optimally chosen by a new hybrid model termed as diversity maintained hybrid whale moth flame optimization (DM-HWM) model.

Results

The accuracy of adopted model at 40th training percentage was 44.72, 11.02, 5.59, 3.92, 3.92, 3.57, 2.59, 1.71, 1.68, and 0.42% superior to traditional artificial neural networks (ANN), support vector machine (SVM), NB, J48, NB-tree, LR, composite hypercube on iterated random projection (CHIRP), CNN, moth flame optimization (MFO), and whale optimization algorithm (WOA) models.

Conclusions

Finally, the superiority of the adopted scheme is validated over other conventional models in terms of various measures.
Doxorubicin loaded magnetism nanoparticles based on cyclodextrin dendritic-graphene oxide inhibited MCF-7 cell proliferation
Authors: Mihanfar Ainaz , Targhazeh Niloufar , Sadighparvar Shirin , Darband Saber Ghazizadeh , Majidinia Maryam , Yousefi Bahman
Published: April 2021

Doxorubicin (DOX) is an effective chemotherapeutic agent used for the treatment of various types of cancer. However, its poor solubility, undesirable side effects, and short half-life have remained a challenge. We used a formulation based on graphene oxide as an anticancer drug delivery system for DOX in MCF-7 breast cancer cells, to address these issues. In vitro release studies confirmed that the synthesized formulation has an improved release profile in acidic conditions (similar to the tumor microenvironment). Further in vitro studies, including MTT, uptake, and apoptosis assays were performed. The toxic effects of the nanocarrier on the kidney, heart and liver of healthy rats were also evaluated. We observed that the DOX-loaded carrier improved the cytotoxic effect of DOX on the breast cell line compared to free DOX. In summary, our results introduce the DOX-loaded carrier as a potential platform for in vitro targeting of cancer cells and suggest further studies are necessary to investigate its in vivo anti-cancer potential.
A tale of two skeletons?
Authors: Kennedy Scott
Published: April 2021

The body of almost every Roman or Byzantine emperor has been lost. This piece draws attention to two skeletons, recovered from a Muslim türbe at Trabzon during World War I by the Russian excavator Feodor Uspensky. Using local oral tradition, Uspensky identified the two bodies he recovered as the Byzantine emperor of Trebizond Alexios IV (1417-1429) and a local Turkish hero Hoşoğlan. Since Uspensky, his identifications have not been challenged nor scientifically examined. This paper argues that Uspensky did not recover just one but two imperial skeletons. It first dissects his identifications, showing how competition for sacred space between Greeks and Turks in the Ottoman period led each community to identify the tomb’s occupants with foundational figures in their communities. After dissecting Uspensky’s identifications, this paper then makes the case that both occupants of this tomb were unidentified members of the Grand Komnenoi family, urging for scientific examination of what may be the only bones of a Byzantine emperor.
Proximal gradient method based robust Capon beamforming against large DOA mismatch
Authors: Thakur Diksha , Baghel Vikas , Talluri Salman Raju
Published: April 2021

The Capon beamformer has excellent resolution and interference suppression capability but due to various attributes of practical environment such as inaccurate and/or insufficient information about the source, transmission medium and antenna array its performance deteriorates. To enhance its performance various efforts have been devoted and one effective method is presented here. In this paper, a novel and efficient robust Capon beamformer is devised which is based on proximal gradient method (PGRCB) and the robustness is achieved through remodeling the optimization problem of standard Capon beamformer (SCB). In the proposed PGRCB, the proximal gradient method is used to formulate a new optimization problem in order to obtain the optimum weights of the robust beamformer. The proposed method can achieve better performance as compared to some recent methods in the literature and its effectiveness is verified by the simulation results.
Growth Marketing Considered Harmful
Authors: Speicher Maximilian
Published: April 2021

In today’s e-commerce industry, conversion rate optimization is often considered essentially the same as user experience optimization. In addition, there is a strong focus on quantitative experimentation, which some deem a jack-of-all-trades solution, often at the expense of qualitative user experience research. Both are worrying developments. This essay elaborates on why it is harmful to consider conversion rate optimization and user experience optimization to be the same thing in the context of growth marketing, and how the three concepts are interrelated.
Paper2Wire – A Case Study of User-Centred Development of Machine Learning Tools for UX Designers
Authors: Buschek Daniel , Anlauff Charlotte , Lachner Florian
Published: April 2021

This paper reflects on a case study of a user-centred concept development process for a Machine Learning (ML) based design tool, conducted at an industry partner. The resulting concept uses ML to match graphical user interface elements in sketches on paper to their digital counterparts to create consistent wireframes. A user study (N=20) with a working prototype shows that this concept is preferred by designers, compared to the previous manual procedure. Reflecting on our process and findings we discuss lessons learned for developing ML tools that respect practitioners’ needs and practices.
Evaluation of an Augmented Reality Instruction for a Complex Assembly Task
Authors: Funk Johannes , Schmidt Ludger
Published: April 2021

This study compares the use of a marker-based AR instruction with a paper instruction commonly used in manual assembly. Hypotheses were tested as to whether the instruction type affects assembly time, number of errors, usability, and employee strain. Instead of student participants and artificial assembly tasks (e. g. Lego assemblies), the study was conducted with 16 trainees in a real workplace for the assembly of emergency door release handles in rail vehicles. Five assembly runs were performed. Assembly times and assembly errors were determined from recorded videos. Usability (SUS) and strain (NASA-TLX) were recorded with questionnaires. After a slower assembly at the beginning, the AR group assembled significantly faster in the fifth run. The comparable number of errors, usability and strain make marker-based AR applications interesting for knowledge transfer in manual assembly, especially due to the easy entrance and low costs.
Polycystic ovary syndrome and reproductive health of women: a curious association
Authors: Zehravi Mehrukh , Maqbool Mudasir , Ara Irfat
Published: April 2021

Reproductive health is a broad concept that encompasses mortality, morbidity, and quality of life associated with the reproductive system, mechanism, and incidents encountered at all ages by men and women. Orthodox Indian society finds the conversation on reproductive health to be a taboo and discourages open conversations about it. Polycystic ovary syndrome (PCOS) is a reproductive-age metabolic endocrine disorder found in females. Females suffering from PCOS are prone to reproductive, metabolic, and cardiovascular disorders. In this paper, we will systematically review about effect of PCOS on Reproductive Health of Women. The numerous electronic databases such as: BMJ, LANCET, PUBMED, Unicef Website, WHO Website and Google Scholar have been comprehensively searched for studies linked to PCOS, its various effects and effect on women’s reproductive health. For additional analyses, we have reviewed reference lists of reviews and collected papers. The effects of PCOS on women’s reproductive health have been verified by several scientific reports worldwide. PCOS is a hormonal condition, as per multiple reports, with the ability to lead to different outcomes. It still appears to be a common cause among females of infertility. An integral aspect of the treatment of this disease is the early diagnosis of long-term morbidities by effective screening tests. In the future, studies must concentrate on the missing holes in our growing perception of this disease. Several studies have confirmed that reproductive morbidity, including irregular uterine bleeding, abortion, miscarriage, and other risk of pregnancy during reproductive years, is associated with PCOS. PCOS is an amalgam of physiological and psychosocial dysfunction, not just an endocrine disorder.
A novel micro-spiral pneumatic selection system for the separation of fresh tea leaves
Authors: Cao Miaolong , Yang Yuanjian , Wu Chuanyu , Cai Chenggan
Published: April 2021

There are no standard machines or systems used for grading the new tea leaves in the market, a micro-spiral pneumatic selection system was designed to separate fresh tea leaves, solving the difficulties in tea leaf selecting and separation. The system can flexibly separate the tea leaves continuously in high quality. And the simulation model was established based on the experiments results to optimize the design parameters. The maximum constant air flow rate separation tests showed that the symmetrical distribution effect of six tubular fans provided better balance than four tubular fans, and three grades of fresh tea can be differentially sorted. Additionally, solid particle simulation tests showed that separation begins at heights between 0.27 and 0.37 m. When the air flow rates range from 4.4 to 6.6 m/s, fresh tea leaves containing only one leaf per stem are well separated from multi-leaf containing stems. Furthermore, solid particle simulation tests indicated that different sizes of fresh tea leaves can be distributed in corresponding annular regions of specific widths; therefore, the flow field simulation tests showed that an optimized system could separate tea leaves according to the number of leaves on the stem. To sum, this study reported a novel micro-spiral pneumatic selection system with high efficiency for the separation of fresh tea leaves.