bluuebunny/crossref_metadata_2025 huggingface dataset:
Community-wide stable isotope analysis reveals two distinct trophic groups in a service-providing carabid community
Authors: Kamenova S. , Leroux C. , Polin S.E. , Plantegenest M.
Published: June 2017

Disentangling trophic interactions among species is important for elucidating mechanisms underlying ecosystem functioning and services. Carabid beetles are an important guild of predators that may regulate pest populations in arable landscapes, but their generalist feeding behavior hinders predictions about their actual contribution to pest control. In order to assess carabids’ potential for pest control, we simultaneously analyzed the carbon and nitrogen stable isotope ratios of a community of 45 co-occurring species in wheat and oilseed rape fields. With the expectation to identify distinct trophic groups based on the mean and the variance of carabid isotopic signatures, we observed a high degree of overlap in trophic positions between species. However, we also observed that species could be successfully categorized into two groups according to whether or not their carbon signatures varied independently from variations in the crop baseline. We interpret these results as differential primary resource uptake or by differential mobility aptitude in foraging. Accordingly, we propose that the isotopic signal can inform us on the presence/absence of links between generalist predators and cultivated plants through the trophic networks they belong to, and consequently on their potential role as pest natural enemies. We therefore suggest the complementarity of stable isotope analysis for obtaining a time-integrated assessment of carabid trophic behavior that may be combined with more direct molecular diet analysis allowing the simultaneous quantification of specific trophic links within agricultural landscapes.
LITIGATING INDIGENOUS PEOPLES’ RIGHTS IN AFRICA: POTENTIALS, CHALLENGES AND LIMITATIONS
Authors: Gilbert Jérémie
Published: June 2017

Adopting a comparative analysis, this article examines some recent litigation which has focused on indigenous peoples’ rights across the African continent. The aim is to explore both the potential and the challenges and limitations of litigation as a tool for supporting the rights of indigenous peoples. The article explores the extent to which a specific African jurisprudence is emerging on issues that are essential to indigenous peoples such as non-discrimination, self-identification, land rights and development. It also focuses on the practical issues that arise when engaging with litigation in order to explore the extent to which litigation can contribute to the legal empowerment of some of the most marginalized indigenous communities in Africa.
DIFFERENTIAL RESPONSES IN FIRST BIRTH BEHAVIOUR TO ECONOMIC RECESSION IN THE UNITED KINGDOM
Authors: Lyons-Amos Mark , Schoon Ingrid
Published: June 2017

Economic conditions have dramatic influences on fertility. This paper evaluates the effect of the 2008 ‘Great Recession’ in the UK on first birth rate, which is the fertility behaviour most susceptible to external economic conditions. The key aim of the study was to assess the effect of the recession on fertility by individual-level characteristics, enabling variation in responses to economic hardship to be observed. Data were from the nationally representative UK Household Longitudinal Study (UK-HLS). Cumulative transition models were used to model the probability of first birth for women between the ages of 17 and 30 in three UK birth cohorts. The effect of the recession was captured using direct measures (local unemployment rates and individual unemployment status) and a pre-/post-comparison, capturing indirect effects. In general, higher birth rates were observed among more disadvantaged women compared with advantaged groups. The effect of the recession was disaggregated by social strata; the overall effect was counter-cyclical although at a slower rate among disadvantaged women.
Bid Resistance by Takeover Targets: Managerial Bargaining or Bad Faith?
Authors: Bates Thomas W. , Becher David A.
Published: June 2017

This paper examines management’s motives for rejecting takeover bids and the associated shareholder wealth effects. We develop measures of initial bid quality and find a significant negative correlation between the quality of a bid and rejection. The likelihood of higher follow-on offers decreases with bid quality and is greater when targets have classified boards and chief executive officers (CEOs) with significant personal wealth tied to the transaction. Target CEOs who fail to close high-quality offers experience a significant rate of forced turnover. Overall, the results support a price improvement motive for contested bids.
FortuneFavors the Bold
Authors: Meneghetti Costanza , Williams Ryan
Published: June 2017

We investigate whether incentives to join theFortune500 affect corporate decisions. Firms closer to the cutoff appear to take actions to join the list by engaging in more mergers and acquisitions activity, bidding for larger targets, and paying higher takeover premia. Further, the relation is stronger for firms with more-entrenched chief executive officers, and the stock market reaction to bids is worse when bidders are close to theFortune500’s cutoff. A 1994 methodological change byFortuneacts as an exogenous shock for identification. Our results suggest that firms try to increase revenues to join theFortune500 but that such actions adversely affect shareholders.
Saterland Frisian
Authors: Peters Jörg
Published: June 2017

Saterland Frisian (Sfrs.Seeltersk) is the only living remnant of Old East Frisian. It is an endangered language, with an estimated number of 2250 speakers (Stellmacher 1998: 27) and is spoken in the municipality of the Saterland (Sfrs.Seelterlound), which is located in the federal state of Lower Saxony in northwestern Germany.
Market Penetration, Institutional Niches and Job Searches in Reforming China
Authors: Huang Xianbi
Published: June 2017

Using an institutional perspective, this paper explores coexisting job search methods in reforming China. Analysis of the 2003 Chinese General Social Survey data shows that China's labour markets are segmented into institutional niches by two key factors: the type of ownership of work organization and the status of the work organization in the market. The effectiveness of job search methods varies across the different institutional niches. Hierarchical arrangements and social networks remain powerful means of obtaining jobs in the state sector, including both monopolistic and competitive work organizations, while job searches using a market-oriented method are comparatively useful for winning jobs in the non-state sector irrespective of whether organizations are competitive or monopolistic in terms of market competition. This paper not only illustrates the value of an institutional approach to labour market research but also reveals the scope of market penetration in China's emerging labour markets.
The epidemiology of invasive pneumococcal disease in older adults in the post-PCV era. Has there been a herd effect?
Authors: CORCORAN M. , VICKERS I. , MERECKIENE J. , MURCHAN S. , COTTER S. , FITZGERALD M. , MCELLIGOTT M. , CAFFERKEY M. , O'FLANAGAN D. , CUNNEY R. , HUMPHREYS H.
Published: June 2017

The 7 and 13-valent pneumococcal conjugate vaccines (PCVs) have reduced the incidence of invasive pneumococcal disease (IPD) in children in many countries. The objective of this work was to assess the impact of PCVs and potential herd-protection in older adults in Ireland. IPD notification and typing data from adults ⩾65 years of age from July 2007 to June 2016 was assessed using national surveillance data. There was a 94% reduction in PCV7 serotypes from 2007–2008 to 2015–2016, incidence rate ratio (IRR 0·05, P < 0·0001). However, there was no decline in the additional PCV13 (PCV13-7) serotypes over the same period (IRR 0·90) nor in comparison with the pre-PCV13 period 2009–2010 (IRR 0·92). The incidence of serotypes in the 23-valent pneumococcal polysaccharide vaccine only (PPV23-PCV13) and non-vaccine types (NVTs) increased significantly (IRR 2·17, P = 0·0002 and IRR 3·43, P = 0·0001 respectively). Consequently, the overall IPD incidence rate in adults has remained relatively unchanged (from 28·66/100 000 to 28·88/100 000, IRR 1·01, P = 0·9477). Serotype 19A and NVTs were mainly responsible for penicillin resistance in recent years. The decline of PCV7 serotypes indicate that the introduction of PCV7 resulted in herd-protection for adults. However, increases in PPV23-PCV13 and NVTs suggest that changes in vaccination strategy amongst older adults are needed to build on the success of PCVs in children.
Down syndrome and transposition of the great arteries
Authors: McCrossan Brian , McCay Nicola
Published: June 2017

There is an old adage in paediatric cardiology that, despite the high prevalence and wide spectrum of CHD, transposition of the great arteries does not occur in trisomy 21. We present a case of transposition of the great arteries, ventricular septal defect, and pulmonary stenosis in a patient with trisomy 21.
FIGHTING POVERTY AND CHILD MALNUTRITION: ON THE DESIGN OF FOREIGN AID POLICIES
Authors: Vasilakis Chrysovalantis
Published: June 2017

This paper investigates how the different food aid programs affect economic development via their effect on the parental trade-off between the number of children and the investment in each child's human capital. This is done in an OLG framework where parents decide on the number of children and the nutrition and secondary schooling of each child. Primary schooling is mandatory. Providing school meals locks countries with no children attending secondary schooling into poverty by reducing the private (nutrition) cost per child. In countries where parents find it optimal to enroll children in secondary schooling, food aid increases the marginal benefit of schooling. Consequently, school feeding programs are conducive to economic development in these countries. If food aid is in the form of a food price subsidy, we show that child nutrition and thus children's human capital increase unambiguously. Although fertility and schooling are not directly affected, a sufficiently high subsidy rate will induce parents to begin to enroll children into secondary schooling by the assumed complementarity between nutrition and schooling in the human capital production function. If the food aid program provides a fixed amount of food per child, this decreases the marginal benefit of parental nutritional investments; therefore, it leads to higher fertility and to lower total provision of nutrition per child.
TECHNOLOGICAL CHANGE DURING THE ENERGY TRANSITION
Authors: van der Meijden Gerard , Smulders Sjak
Published: June 2017

The energy transition from fossil fuels to alternative energy sources has important consequences for technological change and resource extraction. We examine these consequences by incorporating a nonrenewable resource and an alternative energy source in a market economy model of endogenous growth through expanding varieties. During the energy transition, technological progress is nonmonotonic over time: It declines initially, starts increasing when the economy approaches the regime shift, and jumps down once the resource stock is exhausted. A moment of peak-oil does no longer necessarily occur, and simultaneous use of the resource and the alternative energy source will take place if the return to innovation becomes too low. Subsidies to research and development (R&D) and to renewables production speed up the energy transition, whereas a tax on fossil fuels postpones the switch to renewable energy.
A NOTE ON THE IMPLICATIONS OF AUTOMATION FOR ECONOMIC GROWTH AND THE LABOR SHARE
Authors: Prettner Klaus
Published: June 2017

We introduce automation into a standard model of capital accumulation and show that (i) there is the possibility of perpetual growth, even in the absence of technological progress; (ii) the long-run economic growth rate declines with population growth, which is consistent with the available empirical evidence; (iii) there is a unique share of savings diverted to automation that maximizes long-run growth; and (iv) automation explains around 14% of the observed decline of the labor share over the last decades in the United States.
The Political Impact of Displacement: Wartime IDPs, Religiosity, and Post-War Politics in Bosnia
Authors: Zic Borjan
Published: June 2017

Following armed conflict, why do some members of ethno-religious groups vote for political parties that use religious appeals while others do not? I argue that internal displacement shapes the relationship between conflict and post-war political outcomes. Specifically, individuals who become internally displaced during armed conflict will use their religious faith to cope with the trauma of displacement, thereby strengthening their religiosity. This heightened religiosity then leads them to prefer religiously oriented parties after conflict. Analyzing survey data from Bosnian Muslims, I show that internally displaced respondents were more likely to vote for the religious nationalist Party of Democratic Action nearly a decade after conflict. Employing matching analysis, I then verify that these internally displaced persons became more religious than other respondents compared to before the war. My findings therefore provide evidence that trauma and religiosity combine to shape post-war voting behavior for members of ethno-religious groups.
Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart
Authors: Vranas S. , Heinemann G. K. , Liu H. , De Blasio M. J. , Owens J. A. , Gatford K. L. , Black M. J.
Published: June 2017

Low birth weight is associated with increased risk of cardiovascular disease in adulthood. Intrauterine growth restriction (IUGR) hearts have fewer CMs in early postnatal life, which may impair postnatal cardiovascular function and hence, explain increased disease risk, but whether the cardiomyocyte deficit persists to adult life is unknown. We therefore studied the effects of experimentally induced placental restriction (PR) on cardiac outcomes in young adult sheep. Heart size, cardiomyocyte number, nuclearity and size were measured in control (n=5) and PR (n=5) male sheep at 1 year of age. PR lambs were 36% lighter at birth (P=0.007), had 38% faster neonatal relative growth rates (P=0.001) and had 21% lighter heart weights relative to body weight as adults (P=0.024) than control lambs. Cardiomyocyte number, nuclearity and size in the left ventricle did not differ between control and PR adults; hearts of both groups contained cardiomyocytes (CM) with between one and four nuclei. Overall, cardiomyocyte number in the adult left ventricle correlated positively with birth weight but not with adult weight. This study is the first to demonstrate that intrauterine growth directly influences the complement of CM in the adult heart. Cardiomyocyte size was not correlated with cardiomyocyte number or birth weight. Our results suggest that body weight at birth affects lifelong cardiac functional reserve. We hypothesise that decreased cardiomyocyte number of low birth weight individuals may impair their capacity to adapt to additional challenges such as obesity and ageing.
Kochia (Kochia scoparia) Emergence Profiles and Seed Persistence across the Central Great Plains
Authors: Dille J. Anita , Stahlman Phillip W. , Du Juan , Geier Patrick W. , Riffel Jarrett D. , Currie Randall S. , Wilson Robert G. , Sbatella Gustavo M. , Westra Philip , Kniss Andrew R. , Moechnig Michael J. , Cole Richard M.
Published: June 2017

Timing of weed emergence and seed persistence in the soil influence the ability to implement timely and effective control practices. Emergence patterns and seed persistence of kochia populations were monitored in 2010 and 2011 at sites in Kansas, Colorado, Wyoming, Nebraska, and South Dakota. Weekly observations of emergence were initiated in March and continued until no new emergence occurred. Seed was harvested from each site, placed into 100-seed mesh packets, and buried at depths of 0, 2.5, and 10 cm in fall of 2010 and 2011. Packets were exhumed at 6-mo intervals over 2 yr. Viability of exhumed seeds was evaluated. Nonlinear mixed-effects Weibull models were fit to cumulative emergence (%) across growing degree days (GDD) and to viable seed (%) across burial time to describe their fixed and random effects across site-years. Final emergence densities varied among site-years and ranged from as few as 4 to almost 380,000 seedlings m−2. Across 11 site-years in Kansas, cumulative GDD needed for 10% emergence were 168, while across 6 site-years in Wyoming and Nebraska, only 90 GDD were needed; on the calendar, this date shifted from early to late March. The majority (>95%) of kochia seed did not persist for more than 2 yr. Remaining seed viability was generally >80% when seeds were exhumed within 6 mo after burial in March, and declined to <5% by October of the first year after burial. Burial did not appear to increase or decrease seed viability over time but placed seed in a position from which seedling emergence would not be possible. High seedling emergence that occurs very early in the spring emphasizes the need for fall or early spring PRE weed control such as tillage, herbicides, and cover crops, while continued emergence into midsummer emphasizes the need for extended periods of kochia management.
Global Atmospheric Observations May Need Tweaking for Turbulence
Authors: Zastrow Mark
Published: June 2017

A new study overturns an 80-year-old assumption about atmospheric turbulence that may finally resolve discrepancies in observations of atmospheric heat, water vapor, and carbon.
The NF-κB1 is a key regulator of acute but not chronic renal injury
Authors: Fearn Amy , Situmorang Gerhard R , Fox Christopher , Oakley Fiona , Howarth Rachel , Wilson Caroline L , Kiosia Agklinta , Robson Michael G , Mann Derek A , Moles Anna , Sheerin Neil S
Published: June 2017

The NF-κB family of transcription factors is important for many cellular functions, in particular initiation and propagation of inflammatory and immune responses. However, recent data has suggested that different subunits of the NF-κB family can suppress the inflammatory response. NF-κB1, from the locus nfκb1, can inhibit transcription, acting as a brake to the recognised pro-inflammatory activity of other NF-κB subunits. We tested the function of NF-κB1 in an acute (nephrotoxic serum (NTS) nephritis) and a chronic (unilateral ureteric obstruction (UUO)) model of renal injury using NF-κB1 (nfκb1−/−) knockout mice. Deficiency in NF-κB1 increased the severity of glomerular injury in NTS-induced nephritis and was associated with greater proteinuria and persistent pro-inflammatory gene expression. Induction of disease in bone marrow chimeric mice demonstrated that the absence of NF-κB1 in either bone marrow or glomerular cells increased the severity of injury. Early after UUO (day 3) there was more severe histological injury in the nfκb1−/− mice but by day 10, disease severity was equivalent in wild type and nfκb1−/− mice. In conclusion, NF-κB1 modifies acute inflammatory renal injury but does not influence chronic fibrotic injury.
Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells
Authors: Haydn Tinka , Metzger Eric , Schuele Roland , Fulda Simone
Published: June 2017

The lysine-specific demethylase 1 (LSD1) is overexpressed in several cancers including rhabdomyosarcoma (RMS). However, little is yet known about whether or not LSD1 may serve as therapeutic target in RMS. We therefore investigated the potential of LSD1 inhibitors alone or in combination with other epigenetic modifiers such as histone deacetylase (HDAC) inhibitors. Here, we identify a synergistic interaction of LSD1 inhibitors (i.e., GSK690, Ex917) and HDAC inhibitors (i.e., JNJ-26481585, SAHA) to induce cell death in RMS cells. By comparison, LSD1 inhibitors as single agents exhibit little cytotoxicity against RMS cells. Mechanistically, GSK690 acts in concert with JNJ-26481585 to upregulate mRNA levels of the proapoptotic BH3-only proteins BMF, PUMA, BIM and NOXA. This increase in mRNA levels is accompanied by a corresponding upregulation of BMF, PUMA, BIM and NOXA protein levels. Importantly, individual knockdown of either BMF, BIM or NOXA significantly reduces GSK690/JNJ-26481585-mediated cell death. Similarly, genetic silencing of BAK significantly rescues cell death upon GSK690/JNJ-26481585 cotreatment. Also, overexpression of antiapoptotic BCL-2 or MCL-1 significantly protects RMS cells from GSK690/JNJ-26481585-induced cell death. Furthermore, GSK690 acts in concert with JNJ-26481585 to increase activation of caspase-9 and -3. Consistently, addition of the pan-caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVAD.fmk) significantly reduces GSK690/JNJ-26481585-mediated cell death. In conclusion, concomitant LSD1 and HDAC inhibition synergistically induces cell death in RMS cells by shifting the ratio of pro- and antiapoptotic BCL-2 proteins in favor of apoptosis, thereby engaging the intrinsic apoptotic pathway. This indicates that combined treatment with LSD1 and HDAC inhibitors is a promising new therapeutic approach in RMS.
Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling
Authors: Zeng Huijun , Yang Zhao , Xu Ningbo , Liu Boyang , Fu Zhao , Lian Changlin , Guo Hongbo
Published: June 2017

Limited benefits and clinical utility of temozolomide (TMZ) for glioblastoma (GB) are frequently compromised by the development of acquired drug resistance. Overcoming TMZ resistance and uncovering the underlying mechanisms are challenges faced during GB chemotherapy. In this study, we reported that connective tissue growth factor (CTGF) was associated with GB chemoresistance and significantly upregulated in TMZ-treated GB cells. CTGF knockdown promoted TMZ-induced cell apoptosis and enhanced chemosensitivity, whereas its overexpression markedly conferred TMZ resistance in vitro and in vivo. Moreover, CTGF promoted TMZ resistance through stem-like properties acquisition and CD44 interference reversed the CTGF-induced TMZ resistance. Mechanistically, further investigation revealed that the TMZ-induced CTGF upregulation was tissue growth factor (TGF-β) dependent, and regulated by TGF-β1 activation through Smad and ERK1/2 signaling. Together, our results suggest a pivotal role of CTGF-mediated TMZ resistance through TGF-β1-dependent activation of Smad/ERK signaling pathways. These data provide us insights for identifying potential targets that are beneficial for overcoming TMZ resistance in GB.
Cdc20 directs proteasome-mediated degradation of the tumor suppressor SMAR1 in higher grades of cancer through the anaphase promoting complex
Authors: Paul Debasish , Ghorai Suvankar , Dinesh U S , Shetty Praveenkumar , Chattopadhyay Samit , Santra Manas Kumar
Published: June 2017

The Tumor suppressor SMAR1 (scaffold matrix attachment region binding protein 1) has a crucial role in maintaining genomic stability, cell cycle progression and apoptosis.Our previous finding showed that it is highly suppressed in higher grade of cancer. However, the underlying mechanism of this suppression was not well understood. In this study, we show that SMAR1 expression levels are controlled at the proteasomal level by five RING finger E3 ubiquitin ligases including, Cdc20, a substrate receptor of ubiquitin ligase APC/C complex. We found that Cdc20 binds and promotes proteasomal degradation of SMAR1 in a D-box motif dependent manner. Further, our results demonstrated that Cdc20 promotes proteasomal degradation of SMAR1 through K48-linked specific polyubiquitylation, and that short hairpin RNA mediated inactivation of Cdc20 leads to significant stabilization of SMAR1. These findings suggest that Cdc20 is responsible for maintaining the cellular levels of SMAR1. However, since Cdc20 fails to target SMAR1 upon exposure to genotoxic stresses, SMAR1 helps to maintain genomic stability under these conditions through its DNA damage repair activity. Interestingly, Cdc20-mediated degradation of SMAR1 promotes cell migration and invasion.The reciprocal relationship of the duo is evident in breast cancer cell lines as well as in patient samples, suggesting that Cdc20 functions as an important negative regulator of SMAR1 in higher grades of cancer. Our study reveals for the first time, the molecular mechanism associated with lower levels of expression of the important tumor suppressor SMAR1 in higher grades of breast cancer.
BST2 confers cisplatin resistance via NF-κB signaling in nasopharyngeal cancer
Authors: Kuang Chun-mei , Fu Xiang , Hua Yi-jun , Shuai Wen-di , Ye Zhi-hua , Li Yingchang , Peng Qi-hua , Li Yi-zhuo , Chen Shuai , Qian Chao-nan , Huang Wenlin , Liu Ran-yi
Published: June 2017

Concurrent/adjuvant cisplatin-based chemoradiotherapy is regarded as the standard of treatment for locoregionally advanced nasopharyngeal carcinoma (NPC). However, patients who do not respond to cisplatin suffer, rather than benefit, from chemotherapy treatment. The goal of this study was to identify molecules involved in cisplatin resistance and to clarify their molecular mechanisms, which would help in the discovery of potential therapeutic targets and in developing a personalized and precise treatment approach for NPC patients. We previously generated a cisplatin-sensitive NPC cell line, S16, from CNE2 cells and found that eIF3a, ASNS and MMP19 are upregulated in S16 cells, which contributes to their cisplatin sensitivity. In this study, we found that BST2 is downregulated in cisplatin-sensitive S16 cells compared with CNE2 cells. Knockdown of BST2 in NPC cells sensitized their response to cisplatin and promoted cisplatin-induced apoptosis, whereas exogenous overexpression of BST2 increased their cisplatin resistance and inhibited cisplatin-induced apoptosis. Further investigation demonstrated that BST2-mediated cisplatin resistance depended on the activation of the NF-κB signaling pathway and consequent upregulation of anti-apoptotic genes, such as Bcl-XL and livin. Moreover, an analysis of clinical data revealed that a high BST2 level might serve as an independent indicator of poor prognosis in patients with locally advanced NPC treated with platinum-based chemoradiotherapy. These findings suggest that BST2 likely mediates platinum resistance in NPC, offering guidance for personalized and precise treatment strategies for patients with NPC.
VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
Authors: Gao Yao-Hui , Wu Zhao-Xia , Xie Li-Qi , Li Cai-Xia , Mao Yu-Qin , Duan Yan-Tao , Han Bing , Han San-Feng , Yu Yun , Lu Hao-Jie , Yang Peng-Yuan , Xu Tian-Rui , Xia Jing-Lin , Chen Guo-Qiang , Wang Li-Shun
Published: June 2017

The von Hippel-Lindau (VHL) is deficient in ∼70% of clear-cell renal cell carcinomas (ccRCC), which contributes to the carcinogenesis and drug resistance of ccRCC. Here we show that VHL-deficient ccRCC cells present enhanced cytotoxicity of anthracyclines in a hypoxia-inducible factor-independent manner. By subtractive proteomic analysis coupling with RNAi or overexpression verification, aldehyde dehydrogenase 2 (ALDH2) is found to be transcriptionally regulated by VHL and contributes to enhanced anthracyclines cytotoxicity in ccRCC cells. Furthermore, VHL regulates ALDH2 expression by directly binding the promoter of −130 bp to −160 bp to activate the transcription of hepatocyte nuclear factor 4 alpha (HNF-4α). In addition, a positive correlation is found among the protein expressions of VHL, HNF-4α and ALDH2 in ccRCC samples. These findings will deepen our understanding of VHL function and shed light on precise treatment for ccRCC patients.
Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6
Authors: He Ao-Di , Xie Wen , Song Wei , Ma Yuan-Yuan , Liu Gang , Liang Ming-Lu , Da Xing-Wen , Yao Guang-Qiang , Zhang Bi-xiang , Gao Cun-Ji , Xiang Ji-zhou , Ming Zhang-Yin
Published: June 2017

Platelets in the primary tumor microenvironment play crucial roles in the regulation of tumor progression, but the mechanisms underlying are poorly understood. Here, we report that platelet releasates exerted a proliferative effect on hepatocellular carcinoma (HCC) cells both in vitro and in vivo. This effect depended on a reduction of KLF6 expression in HCC cells. After incubation with either platelets or platelet granule contents, SMMC.7721 and HepG2 cells exhibited significant increases in proliferation and decreases in apoptosis. However, no effect was observed when incubating cancer cells with resuspended activated platelet pellet which exhausted of releasates. Platelet releasates also increased the population of HCC cells in the S and G2/M phases of the cell cycle and reduced the cell population in the G0/G1 phase. Moreover, knocking down KLF6 expression significantly diminished the platelet-mediated enhancement of HCC growth. In addition, blocking TGF-β signaling with the TGF-β receptor inhibitor SB431542 counteracted the effect of platelets on KLF6 expression and proliferation of HCC cells. Based on these findings, we conclude that platelet releasates, especially TGF-β, promote the proliferation of SMMC.7721 and HepG2 cells by decreasing expression of KLF6. This discovery identifies a potential new therapeutic target for the prevention and treatment of hepatocellular carcinoma.
Transient cell assembly networks encode stable spatial memories
Authors: Babichev Andrey , Dabaghian Yuri
Published: June 2017

One of the mysteries of memory is that it can last despite changes in the underlying synaptic architecture. How can we, for example, maintain an internal spatial map of an environment over months or years when the underlying network is full of transient connections? In the following, we propose a computational model for describing the emergence of the hippocampal cognitive map in a network of transient place cell assemblies and demonstrate, using methods of algebraic topology, how such a network can maintain spatial memory over time.
Experimental evidence for reciprocity in allogrooming among wild-type Norway rats
Authors: Schweinfurth Manon K. , Stieger Binia , Taborsky Michael
Published: June 2017

If individuals help more those who have previously helped them, stable cooperation may ensue through alternation of roles between donors and recipients. Allogrooming, which is costly to donors and beneficial to recipients, is often exchanged between social partners. Arguably, allogrooming and allopreening are the most frequently exchanged social services and have been used as a standard model of reciprocal cooperation. However, evidence for the application of reciprocity rules among social partners allogrooming each other hitherto is merely correlational. Here, we tested whether female Norway rats (Rattus norvegicus) apply the decision rule characterising direct reciprocity: help someone who has helped you before, by experimentally manipulating both the need for allogrooming and the behavioural response. Furthermore, we checked whether trading of grooming services is influenced by the rank of the social partner. We show that rats groom social partners reciprocally and prefer to do so up the hierarchy, i.e. they groom dominant partners more often than subordinates, while reciprocating with both. This provides experimental evidence that animals render a costly social service by applying reciprocity decision rules when showing a natural hygienic behaviour. The fact that allogrooming is more readily shown up the hierarchy may suggest an appeasing function.
A note on the stationary distribution of stochastic SEIR epidemic model with saturated incidence rate
Authors: Han Qixing , Chen Liang , Jiang Daqing
Published: June 2017

The stochastic SEIR infectious diseases model with saturated incidence rate is studied in this paper. By constructing appropriate Lyapunov functions, we show that there is a stationary distribution for the system and the ergodicity holds provided $${R}_{0}^{s}$$

R

0

s

 > 1. In particular, we improve the results obtained by previous studies greatly, condition in our Theorem is more concise and elegant.
Bounds for coherence of quantum superpositions in high dimension
Authors: Yue Qiu-Ling , Gao Fei , Wen Qiao-Yan , Zhang Wei-Wei
Published: June 2017

Quantum coherence plays a major role in the promotion for quantum information processing and designing quantum technology. Since coherence is rooted in superposition principle, it is vital to understand the coherence change with respect to superpositions. Here we study the bounds for coherence of quantum superpositions in high dimension. We consider three most frequently used measures of coherence, i.e. the relative entropy of coherence, l1 norm of coherence and robustness of coherence. For a quantum state (an arbitrary dimension) and its arbitrary decomposition, we give the upper and lower bounds for coherence of the superposition state in terms of the coherence of the states being superposed.
Identification and expression analysis of chemosensory receptor genes in an aphid endoparasitoid Aphidius gifuensis
Authors: Kang Zhi-Wei , Tian Hong-Gang , Liu Fang-Hua , Liu Xiang , Jing Xiang-Feng , Liu Tong-Xian
Published: June 2017

Olfaction and gustation play critical roles during the host-location search process of insects. Several chemosensory receptor genes are thought to be involved in providing specificity to the olfactory sensory neuron responses. The aphid endoparasitoid, Aphidius gifuensis, has been used as a biological control agent against a variety of aphid species; this parasitoid is able to detect its target host(s) effectively during the parasitic process. To understand the mechanism of host detection in A. gifuensis, we assembled specific antennal transcriptomes of each sex through next generation sequencing technology to identify the major chemosensory receptor genes. Using a bioinformatics screen, we identified 100 olfactory receptors candidates (62 odorant receptors, 15 gustatory receptors, and 23 ionotropic receptors) from the sex-specific antennal transcriptome. In addition, combining with the demonstrated functions of chemosensory genes in other insects, the sex-, tissue-, and host-specific expression profile of chemosensory genes potentially revealed the candidate physiological functions. The identification and expression profile of chemosensory receptor genes in A. gifuensis provide valuable information for understanding and investigating the intraspecific or interspecific chemical communications in the solitary parasitic wasps.
Mycobacterial heat shock protein 65 mediated metabolic shift in decidualization of human endometrial stromal cells
Authors: Subramani Elavarasan , Rameshbabu Arun Prabhu , Jothiramajayam Manivannan , Subramanian Bhuvaneshwaran , Chakravorty Debangana , Bose Gunja , Joshi Mamata , Ray Chaitali Datta , Lodh Indrani , Chattopadhyay Ratna , Saha Sudipto , Mukherjee Anita , Dhara Santanu , Chakravarty Baidyanath , Chaudhury Koel
Published: June 2017

Successful implantation is dependent on the appropriate decidualization of endometrial stromal cells for the establishment of pregnancy in women. Mycobacterial heat shock protein 65 (HSP65) is involved in pathogenesis of the genital tuberculosis (GTB), one of the common causes of infertility in emerging countries. Though implantation failure appears to be the major cause, understanding the status of decidualizaiton process in women diagnosed with GTB has not been thoroughly addressed. We, therefore, explored the effect of HSP65 protein on the endometrial cell metabolism duringin vitrodecidualization. In order to identify the cellular metabolism of decidual cells with and without HSP65 treatment, proton NMR based characterization of metabolites extracted from cells and culture media were performed. In presence of HSP65, significant reduction in the decidual phenotype of endometrial stromal cells and prolactin expression is suggestive of impairment in decidualization. The intracellular and extracellular metabolic changes in HSP65 treated endometrial stromal cells produced a distinct pattern, reflecting the interaction between the protein and cellular metabolism. HSP65 mediated dysregulation in cellular metabolism is associated with poor decidualization. Besides enriching the present knowledge on metabolic changes underlying stromal cells decidualization, these findings assist in identifying potential molecular causes for decidualization failure in GTB women.
Mesoscopic Multimodal Imaging Provides New Insight to Tumor Tissue Evaluation: An Example of Macrophage Imaging of Hepatic Tumor using Organosilica Nanoparticles
Authors: Nakamura Michihiro , Hayashi Koichiro , Kubo Hitoshi , Harada Masafumi , Izumi Keisuke , Tsuruo Yoshihiro , Yogo Toshinobu
Published: June 2017

Multimodal imaging using novel multifunctional nanoparticles provides new approach to biomedical field. Thiol-organosilica nanoparticles containing iron oxide magnetic nanoparticles (MNPs) and rhodamine B (thiol OS-MNP/Rho) were applied to multimodal imaging of hepatic tumor of Long−Evans Cinnamon (LEC) rat. The magnetic resonance imaging (MRI) of LEC rats revealed tumors in the liver clearly and semi-quantitatively due to a labeling of macrophages in liver. The fluorescent imaging (FI) showed abnormal fluorescent patterns of the liver at the mesoscopic level that was between macroscopic and microscopic level. We performed correlation analysis between optical imaging including FI and MRI. We found that the labeled macrophages located specific area in the tumor tissue and influenced the tumor size on MRI. In addition histological observation showed the labeled macrophages related specific tissue in the pathological region. We demonstrated a new approach to evaluate tumor tissue at the macroscopic and microscopic level as well as mesoscopic level using multimodal imaging.
Linking the rotation of a rigid body to the Schrödinger equation: The quantum tennis racket effect and beyond
Authors: Damme L. Van , Leiner D. , Mardešić P. , Glaser S. J. , Sugny D.
Published: June 2017

The design of efficient and robust pulse sequences is a fundamental requirement in quantum control. Numerical methods can be used for this purpose, but with relatively little insight into the control mechanism. Here, we show that the free rotation of a classical rigid body plays a fundamental role in the control of two-level quantum systems by means of external electromagnetic pulses. For a state to state transfer, we derive a family of control fields depending upon two free parameters, which allow us to adjust the efficiency, the time and the robustness of the control process. As an illustrative example, we consider the quantum analog of the tennis racket effect, which is a geometric property of any classical rigid body. This effect is demonstrated experimentally for the control of a spin 1/2 particle by using techniques of Nuclear Magnetic Resonance. We also show that the dynamics of a rigid body can be used to implement one-qubit quantum gates. In particular, non-adiabatic geometric quantum phase gates can be realized based on the Montgomery phase of a rigid body. The robustness issue of the gates is discussed.
Moving Bragg grating solitons in a semilinear dual-core system with dispersive reflectivity
Authors: Chowdhury S. A. M. Saddam , Atai Javid
Published: June 2017

The existence, stability and collision dynamics of moving Bragg grating solitons in a semilinear dual-core system where one core has the Kerr nonlinearity and is equipped with a Bragg grating with dispersive reflectivity, and the other core is linear are investigated. It is found that moving soliton solutions exist as a continuous family of solutions in the upper and lower gaps of the system’s linear spectrum. The stability of the moving solitons are investigated by means of systematic numerical stability analysis, and the effect and interplay of various parameters on soliton stability are analyzed. We have also systematically investigated the characteristics of collisions of counter-propagating solitons. In-phase collisions can lead to a variety of outcomes such as passage of solitons through each other with increased, reduced or unchanged velocities, asymmetric separation of solitons, merger of solitons into a quiescent one, formation of three solitons (one quiescent and two moving ones) and destruction of both solitons. The outcome regions of in-phase collisions are identified in the plane of dispersive reflectivity versus frequency. The effects of coupling coefficient, relative group velocity in the linear core, soliton velocity and dispersive reflectivity and the initial phase difference on the outcomes of collisions are studied.
Differential regulations of vestibulo-ocular reflex and optokinetic response by β- and α2-adrenergic receptors in the cerebellar flocculus
Authors: Wakita Ryo , Tanabe Soshi , Tabei Kazunari , Funaki Asako , Inoshita Takuma , Hirano Tomoo
Published: June 2017

Norepinephrine modulates synaptic plasticity in various brain regions and is implicated in memory formation, consolidation and retrieval. The cerebellum is involved in motor learning, and adaptations of the vestibulo-ocular reflex (VOR) and optokinetic response (OKR) have been studied as models of cerebellum-dependent motor learning. Previous studies showed the involvement of adrenergic systems in the regulation of VOR, OKR and cerebellar synaptic functions. Here, we show differential contributions of β- and α2-adrenergic receptors in the mouse cerebellar flocculus to VOR and OKR control. Effects of application of β- or α2-adrenergic agonist or antagonist into the flocculus suggest that the β-adrenergic receptor activity maintains the VOR gain at high levels and contributes to adaptation of OKR, and that α2-adrenergic receptor counteracts the β-receptor activity in VOR and OKR control. We also examined effects of norepinephrine application, and the results suggest that norepinephrine regulates VOR and OKR through β-adrenergic receptor at low concentrations and through α2-receptor at high concentrations.
Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids
Authors: Artieri Carlo G. , Naor Adit , Turgeman-Grott Israela , Zhou Yiqi , York Ryan , Gophna Uri , Fraser Hunter B.
Published: June 2017

The study of allele-specific expression (ASE) in interspecific hybrids has played a central role in our understanding of a wide range of phenomena, including genomic imprinting, X-chromosome inactivation, and cis-regulatory evolution. However across the hundreds of studies of hybrid ASE, all have been restricted to sexually reproducing eukaryotes, leaving a major gap in our understanding of the genomic patterns of cis-regulatory evolution in prokaryotes. Here we introduce a method to generate stable hybrids between two species of halophilic archaea, and measure genome-wide ASE in these hybrids with RNA-seq. We found that over half of all genes have significant ASE, and that genes encoding kinases show evidence of lineage-specific selection on their cis-regulation. This pattern of polygenic selection suggested species-specific adaptation to low phosphate conditions, which we confirmed with growth experiments. Altogether, our work extends the study of ASE to archaea, and suggests that cis-regulation can evolve under polygenic lineage-specific selection in prokaryotes.
Multiple thermal spin transport performances of graphene nanoribbon heterojuction co-doped with Nitrogen and Boron
Authors: Huang Hai , Gao Guoying , Fu Huahua , Zheng Anmin , Zou Fei , Ding Guangqian , Yao Kailun
Published: June 2017

Graphene nanoribbon is a popular material in spintronics owing to its unique electronic properties. Here, we propose a novel spin caloritronics device based on zigzag graphene nanoribbon (ZGNR), which is a heterojunction consisting of a pure single-hydrogen-terminated ZGNR and one doped with nitrogen and boron. Using the density functional theory combined with the non-equilibrium Green’s function, we investigate the thermal spin transport properties of the heterojunction under different magnetic configurations only by a temperature gradient without an external gate or bias voltage. Our results indicate that thermally-induced spin polarized currents can be tuned by switching the magnetic configurations, resulting in a perfect thermal colossal magnetoresistance effect. The heterojunctions with different magnetic configurations exhibit a variety of excellent transport characteristics, including the spin-Seebeck effect, the spin-filtering effect, the temperature switching effect, the negative differential thermal resistance effect and the spin-Seebeck diode feature, which makes the heterojunction a promising candidate for high-efficiently multifunctional spin caloritronic applications.
Effect of impurity resonant states on optical and thermoelectric properties on the surface of a topological insulator
Authors: Zhong Min , Li Shuai , Duan Hou-Jian , Hu Liang-Bin , Yang Mou , Wang Rui-Qiang
Published: June 2017

We investigate the thermoelectric effect on a topological insulator surface with particular interest in impurity-induced resonant states. To clarify the role of the resonant states, we calculate the dc and ac conductivities and the thermoelectric coefficients along the longitudinal direction within the full Born approximation. It is found that at low temperatures, the impurity resonant state with strong energy de-pendence can lead to a zero-energy peak in the dc conductivity, whose height is sensitively dependent on the strength of scattering potential, and even can reverse the sign of the thermopower, implying the switching from n- to p-type carriers. Also, we exhibit the thermoelectric signatures for the filling process of a magnetic band gap by the resonant state. We further study the impurity effect on the dynamic optical conductivity, and find that the resonant state also generates an optical conductivity peak at the absorption edge for the interband transition. These results provide new perspectives for understanding the doping effect on topological insulator materials.
CH2 Linkage Effects on the Reactivity of Bis(aminophosphine)–Ruthenium Complexes for Selective Hydrogenation of Esters into Alcohols
Authors: Fang Xiaolong , Sun Mingjun , Zheng Jianwei , Li Bin , Ye Linmin , Wang Xiaoping , Cao Zexing , Zhu Hongping , Yuan Youzhu
Published: June 2017

A novel ruthenium complex binding to two subtly different aminophosphine ligands, (o-PPh2C6H4CH2NH2)(o-PPh2C6H4NH2)RuCl2, was successfully isolated. This bis(aminophosphine)–ruthenium complex shows efficient activity in both dimethyl oxalate (DMO) and methyl benzoate (MB) hydrogenation. On the contrast, similar complexes (o-PPh2C6H4NH2)2RuCl2 and (o-PPh2C6H4CH2NH2)2RuCl2, can only effectively catalyze the hydrogenation of DMO and MB, respectively. Our experimental studies in combination of theoretical calculations reveal that the remarkable substrate selectivity in the hydrogenation of esters arises from the nonbonding interactions operated by the CH2 linkage of the ligand.