bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 11 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: June 2023

Supplementary Figure 11
Table S3 from Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma
Authors: Saliby Renee Maria , El Zarif Talal , Bakouny Ziad , Shah Valisha , Xie Wanling , Flippot Ronan , Denize Thomas , Kane M. Harry , Madsen Katrine N. , Ficial Miriam , Hirsch Laure , Wei Xiao X. , Steinharter John A. , Harshman Lauren C. , Vaishampayan Ulka N. , Severgnini Mariano , McDermott David F. , Lee Gwo-Shu Mary , Xu Wenxin , Van Allen Eliezer M. , McGregor Bradley A. , Signoretti Sabina , Choueiri Toni K. , McKay Rana R. , Braun David A.
Published: June 2023

Supplementary table 3
Table S1 from Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma
Authors: Saliby Renee Maria , El Zarif Talal , Bakouny Ziad , Shah Valisha , Xie Wanling , Flippot Ronan , Denize Thomas , Kane M. Harry , Madsen Katrine N. , Ficial Miriam , Hirsch Laure , Wei Xiao X. , Steinharter John A. , Harshman Lauren C. , Vaishampayan Ulka N. , Severgnini Mariano , McDermott David F. , Lee Gwo-Shu Mary , Xu Wenxin , Van Allen Eliezer M. , McGregor Bradley A. , Signoretti Sabina , Choueiri Toni K. , McKay Rana R. , Braun David A.
Published: June 2023

Supplementary table 1
Supplemental Figure 5 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: June 2023

Supplemental Figure 5
Supplemental Figure 4 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: June 2023

Supplemental Figure 4
Figure S10 from Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma
Authors: Saliby Renee Maria , El Zarif Talal , Bakouny Ziad , Shah Valisha , Xie Wanling , Flippot Ronan , Denize Thomas , Kane M. Harry , Madsen Katrine N. , Ficial Miriam , Hirsch Laure , Wei Xiao X. , Steinharter John A. , Harshman Lauren C. , Vaishampayan Ulka N. , Severgnini Mariano , McDermott David F. , Lee Gwo-Shu Mary , Xu Wenxin , Van Allen Eliezer M. , McGregor Bradley A. , Signoretti Sabina , Choueiri Toni K. , McKay Rana R. , Braun David A.
Published: June 2023

Supplementary Figure 10
Figure S1 from Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma
Authors: Saliby Renee Maria , El Zarif Talal , Bakouny Ziad , Shah Valisha , Xie Wanling , Flippot Ronan , Denize Thomas , Kane M. Harry , Madsen Katrine N. , Ficial Miriam , Hirsch Laure , Wei Xiao X. , Steinharter John A. , Harshman Lauren C. , Vaishampayan Ulka N. , Severgnini Mariano , McDermott David F. , Lee Gwo-Shu Mary , Xu Wenxin , Van Allen Eliezer M. , McGregor Bradley A. , Signoretti Sabina , Choueiri Toni K. , McKay Rana R. , Braun David A.
Published: June 2023

Supplementary Figure 1
Data from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-In-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep. , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle. , Kee Bryan K. , Halperin Daniel M. , Nogueras-González Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh-Jasuja Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: June 2023

Abstract
IMA101 is an actively personalized, multi-targeted adoptive cell therapy (ACT), whereby autologous T cells are directed against multiple novel defined peptide-HLA (pHLA) cancer targets. HLA-A*02:01-positive patients with relapsed/refractory solid tumors expressing ≥1 of 8 pre-defined targets underwent leukapheresis. Endogenous T cells specific for up to 4 targets were primed and expanded in vitro. Patients received lymphodepletion (fludarabine, cyclophosphamide), followed by T-cell infusion and low-dose interleukin-2 (Cohort 1). Patients in Cohort 2 received atezolizumab for up to 1 year (NCT02876510). Overall, 214 patients were screened, 15 received lymphodepletion (13 women, 2 men; median age, 44 years), and 14 were treated with T-cell products. IMA101 treatment was feasible and well tolerated. The most common adverse events were cytokine release syndrome (Grade 1, n=6; Grade 2, n=4) and expected cytopenias. No patient died during the first 100 days after T-cell therapy. No neurotoxicity was observed. No objective responses were noted. Prolonged disease stabilization was noted in three patients lasting for 13.7, 12.9, and 7.3 months. High frequencies of target-specific T cells (up to 78.7% of CD8+ cells) were detected in the blood of treated patients, persisted for >1 year, and were detectable in post-treatment tumor tissue. Individual TCRs contained in T-cell products exhibited broad variation in TCR avidity, with the majority being of low-avidity. High-avidity TCRs were identified in some patients’ products. This study demonstrates the feasibility and tolerability of an actively personalized ACT directed to multiple defined pHLA cancer targets. Results warrant further evaluation of multi-target ACT approaches using potent high-avidity TCRs.
Data from Circulating and Intratumoral Immune Determinants of Response to Atezolizumab plus Bevacizumab in Patients with Variant Histology or Sarcomatoid Renal Cell Carcinoma
Authors: Saliby Renee Maria , El Zarif Talal , Bakouny Ziad , Shah Valisha , Xie Wanling , Flippot Ronan , Denize Thomas , Kane M. Harry , Madsen Katrine N. , Ficial Miriam , Hirsch Laure , Wei Xiao X. , Steinharter John A. , Harshman Lauren C. , Vaishampayan Ulka N. , Severgnini Mariano , McDermott David F. , Lee Gwo-Shu Mary , Xu Wenxin , Van Allen Eliezer M. , McGregor Bradley A. , Signoretti Sabina , Choueiri Toni K. , McKay Rana R. , Braun David A.
Published: June 2023

Abstract
Renal cell carcinoma (RCC) of variant histology comprises approximately 20% of kidney cancer diagnoses, yet the optimal therapy for these patients and the factors that impact immunotherapy response remain largely unknown. To better understand the determinants of immunotherapy response in this population, we characterized blood- and tissue-based immune markers for patients with variant histology RCC, or any RCC histology with sarcomatoid differentiation, enrolled in a phase II clinical trial of atezolizumab and bevacizumab. Baseline circulating (plasma) inflammatory cytokines were highly correlated with one another, forming an “inflammatory module” that was increased in International Metastatic RCC Database Consortium poor-risk patients and was associated with worse progression-free survival (PFS; P = 0.028). At baseline, an elevated circulating vascular endothelial growth factor A (VEGF-A) level was associated with a lack of response (P = 0.03) and worse PFS (P = 0.021). However, a larger increase in on-treatment levels of circulating VEGF-A was associated with clinical benefit (P = 0.01) and improved overall survival (P = 0.0058). Among peripheral immune cell populations, an on-treatment decrease in circulating PD-L1+ T cells was associated with improved outcomes, with a reduction in CD4+PD-L1+ [HR, 0.62; 95% confidence interval (CI), 0.49–0.91; P = 0.016] and CD8+PD-L1+ T cells (HR, 0.59; 95% CI, 0.39–0.87; P = 0.009) correlated with improved PFS. Within the tumor itself, a higher percentage of terminally exhausted (PD-1+ and either TIM-3+ or LAG-3+) CD8+ T cells was associated with worse PFS (P = 0.028). Overall, these findings support the value of tumor and blood-based immune assessments in determining therapeutic benefit for patients with RCC receiving atezolizumab plus bevacizumab and provide a foundation for future biomarker studies for patients with variant histology RCC receiving immunotherapy-based combinations.
Supplemental Figure 6 from Siglec-15 promotes evasion of adaptive immunity in B-cell acute lymphoblastic leukemia
Authors: Pillsbury Claire E. , Dougan Jodi , Rabe Jennifer L , Fonseca Jairo A , Zhou Chengjing , Evans Alysa N , Abukharma Hasan , Ichoku Ona , Gonzalez-Flamenco Gloria , Park Sunita I. , Aljudi Ahmed , DeRyckere Deborah , Castellino Sharon M , Rafiq Sarwish , Langermann Solomon , Liu Linda N , Henry Curtis J , Porter Christopher C
Published: June 2023

Sig15 ablation in murine B-ALL promotes an adaptive immune response against leukemia.
Supplementary Figure S3 from Sequential chromogenic immunohistochemistry: spatial analysis of lymph nodes identifies contact interactions between plasmacytoid dendritic cells and plasmablasts
Authors: Claudio Natalie , Nguyen My-Tien , Wanner Adrian , Pucci Ferdinando
Published: June 2023

Trained networks detected artifacts and tissue of interest limits, and excluded them from the analysis.
Supplemental Figure 3 from Siglec-15 promotes evasion of adaptive immunity in B-cell acute lymphoblastic leukemia
Authors: Pillsbury Claire E. , Dougan Jodi , Rabe Jennifer L , Fonseca Jairo A , Zhou Chengjing , Evans Alysa N , Abukharma Hasan , Ichoku Ona , Gonzalez-Flamenco Gloria , Park Sunita I. , Aljudi Ahmed , DeRyckere Deborah , Castellino Sharon M , Rafiq Sarwish , Langermann Solomon , Liu Linda N , Henry Curtis J , Porter Christopher C
Published: June 2023

Sig15 localizes to the Golgi apparatus and TGN in B-ALL.
Movie M1 from Sequential chromogenic immunohistochemistry: spatial analysis of lymph nodes identifies contact interactions between plasmacytoid dendritic cells and plasmablasts
Authors: Claudio Natalie , Nguyen My-Tien , Wanner Adrian , Pucci Ferdinando
Published: June 2023

Cell segmentation of hematoxylin-stained tissue. Example of segmented cells in the sub-capsular region, showing both small round nuclei in lymphocyte-rich areas (B cell follicle, top left) and elongated nuclei in macrophage-rich areas (sub-capsular sinus, middle).
Utilization of Radioactive Contaminated EAF Dust as Material for Making Paving Block
Authors: Supriatno Supriatno , Martono Dwi Nowo , Agustina Haruki
Published: June 2023

Electric arc furnace dust, due to steel fabrication by-products, some of that material has been contaminated with radioactive materials from orphan sources. After calculating the concentration of radionuclide activity, it is known that the material meets the criteria for clearance of application and can be used for other purposes according to the appropriate characteristics. By determining the clearance, EAF dust will be processed through a stabilization/solidification method to be used as a material for making paving blocks. Through elemental analysis of EAF dust using the Micro-XRF method, it is known that sample 1 has a Ca content of 3.9%, CaO is 5.51%, Si is 0.64%, and SiO2 is 1.36%, while sample 2 has Ca content. 4.8%, CaO 6.74% Si 0.63% and SiO2 1.34%. The compressive strength test results based on Indonesian National Standard (SNI) 03-0691-1996 give the results of paving blocks included in quality D with a value of 9.2 MPa which can be used for parks or other purposes. In the calculation of cost savings analysis, determining the clearance for EAF dust can provide cost savings of Rp. 205,562,000 compared to if it had to be managed as radioactive waste. The production cost for one paving block using a mixture of EAF dust is Rp. 2,213.77 or Rp. 97,405.88 for units per m2.
EntrepRise Food Garden in Facebook: The Efficiency of Social Advertising among College Students
Authors: Aguilar Teresa A. , Tombocon Nonalyn D.
Published: June 2023

One of the most important social developments of the past ten years has been Facebook's meteoric ascent to prominence as a social networking site. Organizations seek to use Facebook for a variety of reasons, including to exchange and disseminate information, sell goods or services, maintain contact with current and new consumers, learn more about their customers, and obtain additional benefits. Some of these objectives are listed below. This study's objective is to investigate and evaluate the efficiency of using Facebook as a medium for advertising purposes. Facebook is the focus of this study. It will make an effort to explain how effective Facebook is as a site for advertising and how that relates to the benefits that may be acquired, and it will do so by demonstrating how effective Facebook is as a site for advertising. College students who frequently encounter Facebook adverts on their mobile devices are going to be the focus of a survey that will be carried out with the use of a random sampling method. Facebook is helpful in describing new products and promoting them in a way that either creates or improves brand impressions in a range of markets and cultural contexts. This may be accomplished in different ways. It is essential for businesses to have a working knowledge of how to promote on Facebook and other social media platforms, particularly if they intend to expand their customer base among college students. In particular, it is essential for businesses to have a working knowledge of how to promote on Instagram.
Factors that Correlate Between Dividend Signaling and Dividend Acceleration Through Digital Investment Among Online Investors in Iligan City
Authors: Aguilar Jay Cob , Perion Jenvy , Sanchez Lady Lou , Abiol Michael Jere
Published: June 2023

Digital investments are becoming mainstream but must be secured to avoid sudden loss. This study measures the correlation between dividend signaling and acceleration through digital assets among online jobbers in Iligan City. It has become a full-fledged investment tool, creating a new, booming market with unknown potential. Thanks to the Internet, many businesses are interconnected worldwide, which sparked the industrial revolution centered on globalization. Several solutions have been developed to provide fast and low-cost payments globally in the Philippines, but third parties manage these payments. Cryptocurrency has drawn the attention of online jobbers during the lockdown, but many people need to learn what they can do for financial services or start investing. This research employed a descriptive correlational research design to describe the profile of respondents in terms of age, gender, salary, Investment capital, and length of the Investment. It was a correlation to determine the relationship between demographic profiles and dividend signaling in dividend acceleration. Only those online Investors who were available and signified their interest in participating in the study were included as the sources of the respondents. The research environment of this study covered online Investors in Iligan City. This study examines how investing in digital Investment has become a full-fledged investment tool, enabling rapid and low-cost payments worldwide. It is recognized in the market for dividend signaling and acceleration, but many people hesitate to start investing. Some of the biggest financial companies still need to build and launch digital investment solutions, creating a new, booming market with unknown potential.
Innovative Leadership Practices and Management Styles of School Heads in the Schools Division of Bulacan
Authors: Hernandez Mhelbie M. , Mendoza Sherlaine D. C. , Pacheco Marichrin M.
Published: June 2023

The study aimed to describe and examine school heads’ innovative leadership practices and management styles among school heads assigned in Bustos District in the Schools Division of Bulacan. The study was participated by thirteen (13) school heads who were purposively drawn by the researchers. Results revealed that school heads always practiced innovative leadership practices in terms of strategic thinking, innovative thinking, action patterns and interpersonal skills. Hence, school heads always practiced sound management styles which enabled them to create sound and efficient managerial and supervisory functions. Further, strategic thinking is negatively correlated with instructional leadership as implemented by the school heads.
The Impact of Reflective Leadership on Workplace Belongingness: A Gender-Inclusive Analysis Using a Convergent Mixed Methods Approach
Authors: Caminong Joliber M. , Tanpoco Manuel R. , Morales Retchell Rublin L. , Pitargue Kevin S.
Published: June 2023

This paper examines the impact of reflective leadership on workplace belongingness, with a particular focus on gender differences. Through a combined approach of thematic and quantitative analyses, the study explores the factors that contribute to workplace belongingness and investigates potential variations in these factors based on gender. The findings reveal that reflective leadership positively influences workplace belongingness, with employees perceiving higher levels of reflective leadership in their leaders reporting higher levels of belongingness. The study identifies a safe environment, open communication, and challenging beliefs and assumptions as significant components of reflective leadership that impact workplace belongingness. The thematic analysis highlights the importance of psychological safety, effective communication, the value of work and purpose, and openness to change in fostering workplace belongingness. The quantitative analysis further reveals that the relationship between reflective leadership and workplace belongingness is stronger for female employees compared to male employees. The study emphasizes the need to consider gender-specific factors when promoting workplace belongingness, and it suggests strategies for organizations and leaders to create a positive work environment that enhances belongingness. These strategies include fostering a safe and supportive environment, promoting open communication, encouraging critical thinking, and implementing gender-specific initiatives and policies. The findings contribute to the existing literature by shedding light on the complex relationship between reflective leadership, workplace belongingness, and gender. Overall, promoting workplace belongingness contributes to improved employee well-being, satisfaction, engagement, and organizational performance.
Salidroside Attenuates Cisplatin-Induced Ototoxicity: An Experimental Study In Vitro and In Vivo
Authors: Jiang Kanglun , Wang Tan , Zhao Zirui , Zhou Lei , Jiang Huaili , Shen Na , Wu Daquan , Huang Xinsheng
Published: June 2023

Oxidative damage to hair cells is the major cause of ototoxicity induced by cisplatin (cis)-based chemotherapy. In this study, we aimed to assess how salidroside (SAL) protected cochlear explants (CEs) and HEI-OC1 cell lines against cis-induced ototoxicity and reduced relative hearing
loss in mouse models. Furthermore, the protective mechanism of the Nrf2/ARE pathway was investigated. Cell Counting Kit-8 was used to measure the viability of HEI-OC1 cells. Flow cytometry and the TUNEL assay were used to evaluate cell apoptosis. Flow cytometry was used to measure intracellular
reactive oxygen species (ROS). Immunofluorescence staining determined the changes in mitochondrial membrane potential (ΔΨm). Western blot was used to measure the levels of caspase-3 and Nrf-2. An analysis of Nrf2 and target gene levels of expression was conducted using qRT-PCR.
Hearing was monitored using auditory brainstem response audiometry. In cochlear explants, SAL inhibits cis-induced apoptosis of HEI-OC1 cells and decreased hair cell apoptosis. SAL inhibited cis-induced apoptosis by lowering intracellular ROS, preserving mitochondrial function, and reducing
caspase-3 expression. Moreover, auditory cells were protected from the toxic effects of cis by the Nrf2-ARE pathway after treatment with SAL. In Vivo, SAL could protect against cis-induced hearing loss, and the use of the PLGA-poloxamer nanohydrogel as a carrier increased the protection
efficiency of SAL. Through its ability to reduce oxidative stress, SAL could protect auditory cell lines from cis-induced apoptosis In Vitro and attenuate cis-induced hearing loss In Vivo. Nano-based drug delivery can improve the protection efficiency of SAL. Further research
should be conducted on the antioxidant capacity of SAL and its use in ototoxicity.
Through the Lenses of the Sociology of News Production: An Assessment of Social Media Applications and Changing Newsroom Cultures in Lesotho
Authors: Makwambeni Blessing , Matsilele Trust , Msimanga Mbongeni Jonny
Published: June 2023

Using Lesotho as our case study and a qualitative methodology consisting of semi-structured interviews with journalists from three of the country’s leading newspapers – The Post, News Day and Lesotho Times – the study examined how social media applications are being embraced and changing news production and newsroom cultures in the country. The findings of the study show the pervasiveness of social media applications and their integration into news ecologies in Lesotho. The paper contends that mutations of the sociology of news provide a useful lens for examining how newsrooms are integrating far-reaching new technologies into newsrooms in the global South.
Broadcasting Out-Group Repression to the In-Group: Evidence From China
Authors: Baggott Carter Erin , Carter Brett L.
Published: June 2023

Many autocrats govern with an in-group, whose support must be secured, and an out-group, which is subject to repression. How do autocrats exploit in-group/out-group dynamics to secure their survival? One strategy, we argue, is to broadcast out-group repression to the in-group as a signal of the regime’s capacity for violence. Empirically, we focus on China, where the government represses ethnic Uyghurs in Xinjiang. Drawing on 1 million articles from six propaganda newspapers, we show that the regime broadcasts out-group repression to urban elites on each anniversary of the 1989 Tiananmen Square massacre, when 10% of Beijing residents joined anti-regime protests. To understand its effects, we conducted a survey experiment balanced on the national census during the June 2020 Tiananmen anniversary. Using a list experiment to mitigate preference falsification, we show that CCP propaganda about Uyghurs during the Tiananmen anniversary discourages protests among politically engaged urban elites because they fear repression.
Inhibition of Mertk Signaling Enhances Bone Healing after Tooth Extraction
Authors: Decker A.M. , Matsumoto M. , Decker J.T. , Roh A. , Inohara N. , Sugai J. , Martin K. , Taichman R. , Kaigler D. , Shea L.D. , Núñez G.
Published: June 2023

Regeneration of alveolar bone is an essential step in restoring healthy function following tooth extraction. Growth of new bone in the healing extraction socket can be variable and often unpredictable when systemic comorbidities are present, leading to the need for additional therapeutic targets to accelerate the regenerative process. One such target is the TAM family (Tyro3, Axl, Mertk) of receptor tyrosine kinases. These proteins have been shown to help resolve inflammation and maintain bone homeostasis and thus may have therapeutic benefits in bone regeneration following extraction. Treatment of mice with a pan-TAM inhibitor (RXDX-106) led to accelerated alveolar bone fill following first molar extraction in a mouse model without changing immune infiltrate. Treatment of human alveolar bone mesenchymal stem cells with RXDX-106 upregulated Wnt signaling and primed the cells for osteogenic differentiation. Differentiation of human alveolar bone mesenchymal stem cells with osteogenic media and TAM-targeted inhibitor RXDX-106 (pan-TAM), ASP-2215 (Axl specific), or MRX-2843 (Mertk specific) showed enhanced mineralization with pan-TAM or Mertk-specific inhibitors and no change with Axl-specific inhibitor. First molar extractions in Mertk–/– mice had increased alveolar bone regeneration in the extraction socket relative to wild type controls 7 d postextraction. Flow cytometry of 7-d extraction sockets showed no difference in immune cell numbers between Mertk –/– and wild type mice. RNAseq of day 7 extraction sockets showed increased innate immune-related pathways and genes associated with bone differentiation in Mertk –/– mice. Together, these results indicate that TAM receptor signaling, specifically through Mertk, can be targeted to enhance bone regeneration after injury.
Increased incidence of mixed drug toxicity deaths involving tapentadol – A forensic study
Authors: Stephenson Lilli , van den Heuvel Corinna , Humphries Melissa , Scott Timothy , Byard Roger W
Published: June 2023

Tapentadol is a relatively new synthetic opioid analgesic prescribed for the management of moderate to severe pain. While tapentadol has been shown to be more effective than traditional opioid analgesics, it still carries the risk of addiction, abuse, and misuse. In Australia, tapentadol has become one of the top five most commonly prescribed opioid drugs, with prescriptions increasing by approximately 150,000 each year since it first became available. The rapid increase in tapentadol prescriptions has occurred in parallel to an increasing number of post-mortem tapentadol detections in South Australia (SA). While the number of deaths in SA related to tapentadol use was low in the current study, findings suggest that an increasing trend of deaths involving tapentadol will continue in parallel to a rapidly increasing number of prescriptions, mirroring trends associated with traditional opioids in SA. As a comparatively new opioid analgesic, monitoring future trends will be important to determine if additional prescribing education, intervention, or restrictions are required.
Understanding conversion to Jehovism among Indigenous peoples: The case of the Kitigan Zibi Anishinabeg
Authors: Simard-ÉMond Arnaud
Published: June 2023

Although present in Aboriginal communities since the early 1930s, Jehovism among Indigenous peoples in Canada and the United States has not yet been the subject of any published ethnographic, sociological, or historical study. This article presents the result of the first ethnographic study with Jehovah’s Witnesses among Aboriginal peoples in Canada. From an online field of research spanning over a period of 10 months with Anishinabe (Algonquin) Witnesses from Kitigan Zibi (Outaouais, Quebec), I explore the motivations behind the decision to become a Jehovah’s Witness for the latter. I also show that the first conversions in Kitigan Zibi are mainly due to a dual historical context that created a fertile ground for conversion. Finally, I propose the concept of ‘small-scale conversion’ as another way to conceive the intergenerational transmission of religion.
Deliberative Boundary Work for Sustainable Finance: Insights from a European Commission expert group
Authors: Giamporcaro Stéphanie , Gond Jean-Pascal , Louche Céline
Published: June 2023

To explain how multistakeholder groups organize democratic deliberations about complex sustainability issues, organizational scholars have focused on the key role of deliberative capacity, which encompasses the dimensions of inclusiveness, authenticity and consequentiality. However, the tensions inherent to the search of these three dimensions have been overlooked. In this paper, we argue that focusing on how spaces for deliberation are designed can help one understand how to manage such tensions. We identified the boundary work practices that shape the design of deliberative spaces and generate deliberative capacity properties in a high-level expert group (HLEG) launched by the European Commission about sustainable finance regulation. Our results show how these boundary work practices help balance deliberative tensions. We advance deliberation studies by conceptualizing deliberative boundary work, explaining how deliberative capacity is spatially generated and showing how deliberative tensions are balanced. We also contribute to boundary work theory by making explicit the deliberative nature of configuring boundary work and showing its relevancy to regulatory settings.
Lane Management Strategies in a Connected Environment: Analysis of Freight Corridor Scenarios for I-710 in Southern California
Authors: Ramirez Ibarra Monica , Saphores Jean-Daniel M.
Published: June 2023

Connected vehicles (CVs) and their supporting infrastructure are expected to play an important role in the management of traffic congestion. As highway expansion projects are becoming less common, deploying emerging technologies is essential to make the most of the current road infrastructure. Most published studies report that CVs improve traffic performance only marginally. Here, we propose that CVs drive cooperatively with cooperative adaptive cruise control (CACC)-enabled vehicles by designating a CACC lane for periods with high flows of slow-moving heavy-duty drayage trucks. To assess if this approach could help absorb year 2035 projected drayage traffic increases at the Ports of Los Angeles and Long Beach, which is the largest port complex in the U.S.A., we analyze three 2035 scenarios for I-710, a key freeway for freight transportation in Southern California: (1) CACC-enabled vehicles are deployed under mixed traffic conditions; (2) CACC-enabled vehicles are restricted to the first lane (left-most lane); (3) the first lane is reserved for CACC-enabled vehicles, and access is optional. Our results suggest that substantial speed improvements can be obtained, but only when the first lane is CACC reserved with optional access, because this approach creates more platooning opportunities and thus helps maximize the benefits of CACC.
Biomechanical Evaluation of Posterior Shoulder Instability With a Clinically Relevant Posterior Glenoid Bone Loss Model
Authors: Waltz Robert A. , Brown Justin , Brady Alex W. , Bartolomei Christopher , Dornan Grant J. , Miles Jon W. , Arner Justin W. , Millett Peter J. , Provencher Matthew T.
Published: June 2023

Background:

Existing biomechanical studies of posterior glenoid bone loss and labral pathology are limited by their use of anterior instability models, which differ in both orientation and morphology and have been performed in only a single, neutral arm position.

Purpose:

To evaluate the biomechanical effectiveness of a posterior labral repair in the setting of a clinically relevant posterior bone loss model in various at-risk arm positions.

Study Design:

Controlled laboratory study.

Methods:

Ten fresh-frozen cadaveric shoulders were tested in 7 consecutive states using a 6 degrees of freedom robotic arm: (1) native, (2) posterior labral tear (6-9 o’clock), (3) posterior labral repair, (4) mean posterior glenoid bone loss (7%) with labral tear, (5) mean posterior glenoid bone loss with labral repair, (6) large posterior glenoid bone loss (28%) with labral tear, and (7) large posterior glenoid bone loss with labral repair. Bone loss was created using 3-dimensional printed computed tomography model templates. Biomechanical testing consisted of 75 N of posterior-inferior force and 75 N of compression at 60° and 90° of flexion and scaption. Posterior-inferior translation, lateral translation, and peak dislocation force were measured for each condition.

Results:

Labral repair significantly increased dislocation force independent of bone loss state between 10.1 and 14.8 N depending on arm position. Dislocation force significantly decreased between no bone loss and small bone loss (11.9-13.5 N), small bone loss and large bone loss (9.4-14.3 N), and no bone loss and large bone loss (21.2-26.5 N). Labral repair significantly decreased posterior-inferior translation compared with labral tear states by a range of 1.0 to 2.3 mm. In the native state, the shoulder was most unstable in 60° of scaption, with 29.9 ± 6.1-mm posterior-inferior translation.

Conclusion:

Posterior labral repair improved stability of the glenohumeral joint, and even in smaller to medium amounts of posterior glenoid bone loss the glenohumeral stability was maintained with labral repair in this cadaveric model. However, a labral repair with large bone loss could not improve stability to the native state.

Clinical Relevance:

This study shows that larger amounts of posterior glenoid bone loss (>25%) may require bony augmentation for adequate stability.
A Systematic Literature Review: The Self-Concept of Students With Learning Disabilities
Authors: Yakut Ayse Dilsad , Akgul Savas
Published: June 2023

Since the learning disability (LD) population comprises the largest group receiving special education services, there is a need for research to examine the self-concept of this population at a global level. This systematic literature review synthesized 20 years of quantitative research ( k = 16) about the self-concept of students with LD. The overarching theme was that the diagnosis of LD relies on divergent criteria among the studies reviewed. While the academic self-concept was the center of the research, regardless of its domains, results indicated that students with LD had a lower level of self-concept. To have a deeper understanding of the phenomenon, an instrument specifically designed for assessing self-concept of students with LD is needed. Limitations of the study and implications for research and practice are discussed.
Lessons From Canadian Judgments: The Consideration of Culture in Intimate Partner Violence Legal Cases Involving Asian Canadians
Authors: Liu Kyara J. , Cook Alana N. , Jiang Ruijie
Published: June 2023

Despite the pervasiveness of intimate partner violence (IPV) in Canada, research examining IPV in the context of Asian Canadians is scarce. Our study examined whether and how Canadian judges consider culture when determining a sentence in IPV cases involving an Asian offender and/or an Asian victim. We systematically searched for publicly published cases through CanLII. A total of 50 cases met the inclusion criteria. Cultural themes were identified using a direct content analysis approach to capture a priori themes in the literature, as well as identify any other factors considered. Our findings indicated culture was most often considered in only a superficial way ( n = 31, 62.0%), where judges only made statements that simply identified the ethnicity of the offender and not how culture may have impacted the case. When examining cases where culture was meaningfully considered there were no prominent culture themes identified (all themes present in <14% of cases). We suggest this may not only reflect the heterogeneity of Asian Canadians, but could also reflect the lack of cultural consideration by the judges. Cultural factors were also rarely considered explicitly as an aggravating or mitigating factor in a case ( n = 2; 4.0% and n = 7; 14.0% of the total sample, respectively). The findings reveal the current lack of meaningful consideration of culture in IPV legal cases involving Asian Canadians. We outline how this contrasts the increased attention to the meaningful consideration of culture in the Canadian legal arena and prompt all professionals involved in assessing and managing IPV risk to consider racial, ethnic, and cultural factors in these cases.
Exploring the Impact of the COVID-19 Pandemic on Employees’ Workplace Health Promotion Preferences
Authors: Hammerback Kristen , Strait Michelle , Kohn Marlana J. , Garcia Cinthya , Harris Jeffrey R. , Hannon Peggy A.
Published: June 2023

Purpose

The COVID-19 pandemic has led to profound changes in the workplace as well as increases in stress, missed preventive care, and other health concerns. There is limited research since the onset of the pandemic on employees’ primary health concerns and their willingness to engage with workplace health promotion (WHP) programs to address these needs. We conducted this survey about employees’ current health priorities as a first step to exploring whether WHP programs need to evolve to be responsive to employees’ needs at this stage of the pandemic.

Design

National cross-sectional survey.

Setting

United States, April 29-May 5, 2022.

Subjects

2053 Americans employed part or full time.

Measures

17-item online survey assessing demographics, health priorities, and impact of the pandemic on health.

Analysis

Descriptive statistics, SPSS Version 19.

Results

Employees’ most common health concerns included work/life balance and stress (each cited by 55%). Nearly half (46%) said their health or well-being was affected by the pandemic; within this group, the most common concerns were stress (66%), anxiety (61%), sleep (49%), and depression (48%). Almost all (94%) indicated they would be open to receiving support from their employers.

Conclusion

This research is a first step in learning about employees’ current health priorities and how they may have changed. WHP researchers and practitioners can determine how their programs align with current priorities. Our future research will explore employees’ preferences, heath behaviors, and their current workplace environments in more depth.
On fabrication of acrylonitrile butadiene styrene-zirconium oxide composite feedstock for 3D printing-based rapid tooling applications
Authors: Ranjan Nishant , Tyagi Rashi , Kumar Ranvijay , Kumar Vinay
Published: June 2023

The 3D-printed rapid tools are being used in finishing operations such as drilling, milling, broaching, roller burnishing, and other finishing operations that need anti-wear plastic composite materials. Zirconium oxide (ZrO2) is one of the ceramic materials which is highly appreciated due to its anti-wear properties. This study aims to develop the ZrO2 ceramic particles reinforced acrylonitrile butadiene styrene (ABS) thermoplastic composite feedstock filaments for 3D printing of rapid tools. In the first stage, the multiple numbers (as per Taguchi L9 orthogonal array (OA)) of ABS-ZrO2 feedstock filaments were developed by varying the loading of ZrO2 in ABS matrix (2 wt.%, 4 wt.%, and 6 wt.%), processing temperature (200, 205 and 210°C), and rotation speed of screw (4, 6 and 8 RPM). The optimum setting obtained for manufacturing ABS-ZrO2 composite feedstock filaments is the combination of 2% ZrO2 loading, 205°C processing temperature, and 6 RPM screw speed. In the next stage, fused filament fabrication (FFF) based 3D printing has been used to prepare the rapid tools. The wear test performed for 3D printed ABS-ZrO2 composites rapid tools shows only .62% weight loss which is lower as compared to virgin ABS (.91% weight loss). The results of the study are supported by fracture analysis, morphology, and mechanical properties.
Collaborative agency and relationality in a high school/college poetry partnership
Authors: Conrad Rachel , Andrews Casey Zella
Published: June 2023

This essay engages with ideas of agency and relationality to reimagine possibilities for young people’s modes of learning about and creating poetry. We describe a partnership between a high school and college class in which we minimized our authority as instructors to make space for young people’s collaborative agency in shaping a poetry exchange project. Our analysis of participants’ references to relationality in a post-project survey revealed relational dimensions of participants’ learning, influencing, and creating as supported by collaborative agency.
Indirect rule and mass threat: Two paths to direct rule
Authors: Broman Benjamin
Published: June 2023

What is the impact of popular discontent on the transition from indirect to direct rule? The current literature suggests contrasting theories, variously arguing that rulers are more likely to govern directly when facing either a particularly high or particularly low probability of mass resistance. I reconcile these views by arguing that the decision to rule indirectly is subject to competing dilemmas. In a formal model, I show that these twin tensions influence the choice to centralize power in opposing manners. Accordingly, there are two distinct political logics driving direct rule: one resulting from a high likelihood of revolt and the other from a low likelihood, with contrasting comparative statics. The model therefore reconciles contrasting views in the literature. I illustrate the model's logic with reference to key cases and provide heuristics for predicting comparative statics in new empirical settings.
Significant hypomethylation of MMP9 gene promoter in patients with systemic lupus erythematosus
Authors: Ehtesham Naeim , Mosallaei Meysam , Zaboli Mahdiabadi Morteza , Kenarangi Taiebe , Farhadi Arezoo , Heidari Mohammad Foad , Soroush Mohsen , Nasrollahzadeh Sabet Mehrdad , Behroozi Javad
Published: June 2023

Objective

Scholars are exploring novel diagnostic and prognostic biomarkers with higher sensitivity and specificity for systemic lupus erythematosus (SLE). In this regard, DNA methylation alterations have aroused attention. The association between the dysfunction of MMP9 and TNFAIP3 genes and SLE has been previously demonstrated. Therefore, in this study, we investigated the methylation level of MMP9 and TNFAIP3 promoters in peripheral blood mononuclear cells (PBMCs) of SLE patients and healthy controls.

Methods

Eighty Iranian SLE patients and 77 healthy individuals were enrolled. The methylation quantification endonuclease-resistant DNA (MethyQESD) method was used to assess methylation levels of MMP9 and TNFAIP3 in extracted DNA of PBMCs. To quantify the diagnostic utility of the promoter methylation level of these genes, the receiver operating characteristic (ROC) curve was constructed.

Results

MMP9 promoter was significantly hypomethylated in SLE patients compared with healthy people ( p < 0.001), while there was no significant difference in terms of TNFAIP3 promoter methylation levels ( p = 0.167). Also, this differential MMP9 methylation was observed in patients with renal involvement and patients without renal involvement (42.07 ± 25.73 vs 56.74 ± 29.71, p = 0.007). ROC analyses indicated that the diagnostic power of the MMP9 promoter methylation level for SLE was 0.839 [95% CI (0.781–0.911)]. Moreover, MMP9 methylation level was negatively correlated with creatinine and anti-dsDNA concentration and positively correlated with C3 and C4 levels.

Conclusion

The results of this study highlight the application of MMP9 methylation level in PBMCs of SLE patients as a diagnostic biomarker.
Distributive Justice in International Environmental Policy: Axiomatic Foundation and Exemplary Formulation
Authors: Helm Carsten , Simonis Udo E.
Published: June 2023

Proceeding on a limited number of general, widely accepted equity criteria, we develop a proposal for distributing common resources. In particular, the proposed fair division mechanism is individually rational, envy-free, Pareto-efficient and satisfies the stand alone test, which follows as a minimum requirement from the resource and population monotonicity criteria. Applied to international climate policy, the thrust of this proposal is that the South should initially be fully compensated for the greenhouse gas abatement measures it is to undertake as a result of efficiency considerations.
Postmodernism, Value and Objectivity
Authors: Attfield Robin
Published: June 2023

The first half of this paper replies to three postmodernist challenges to belief in objective intrinsic value. One lies in the claim that the language of objective value presupposes a flawed, dualistic distinction between subjects and objects. The second lies in the claim that there are no objective values which do not arise within and/or depend upon particular cultures or valuational frameworks. The third comprises the suggestion that belief in objective values embodies the representational theory of perception. In the second half, a defence is offered of belief in objective intrinsic value. Objectivists hold that axiological properties supply interpersonal reasons for action for any relevant moral agent. The intrinsically valuable is understood as what there is reason to desire, cherish or foster in virtue of the nature of the state or object concerned. The concept of intrinsic value is shown to be instantiated, and defended against a range of criticisms.
Intrinsic Value and Care: Making Connections through Ecological Narratives
Authors: Preston Christopher J.
Published: June 2023

Vitriolic debates between supporters of the intrinsic value and the care approaches to environmental ethics make it sound as though these two sides share no common ground. Yet ecofeminist Jim Cheney holds up Holmes Rolston's work as a paragon of feminist sensibility. I explore where Cheney gets this idea from and try to root out some potential connections between intrinsic value and care approaches. The common ground is explored through Alasdair MacIntyre's articulation of a narrative ethics and the development of the notion of an ecological and evolutionary tradition.
The Future – for Better or Worse
Authors: Partridge Ernest
Published: June 2023

Alan Carter correctly argues that Thomas Schwartz's ‘future persons paradox’ applies with equal force to utilitarianism, rights theory and Aristotelian ethics. His criticism of Rawls's ‘justice between generations’ is less successful, because of his failure (and perhaps Rawls's as well) to fully appreciate the hypothetical nature of the ‘original position’. Carter's attempt to refute Schwartz's argument by focusing on the individuality of moral action fails, since it evades the essential point of Schwartz's argument. The best response to Schwartz is to concede the essential validity of his argument and then to turn that argument into an ad absurdum refutation of his central premise, ‘the person affecting principle’.