bluuebunny/crossref_metadata_2025 huggingface dataset:
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy
Authors: Xiao Yu , Pan Tao , Da Wuren , Liu Yuanding , Chen Shuangya , Chen Daiquan , Liu Keying , Zheng Yihan , Xie Daolong , Gao Yuan , Xu Haiyan , Sun Yang , Tan Weihong
Published: October 2024

Pancreatic cancer is one of the most malignant tumors with the highest mortality rates, and it currently lacks effective drugs. Aptamer-drug conjugates (ApDC), as a form of nucleic acid drug, show great potential in cancer therapy. However, the instability of nucleic acid-based drugs in vivo and the avascularity of pancreatic cancer with dense stroma have limited their application. Fortunately, VNP20009, a genetically modified strain of Salmonella typhimurium, which has a preference for anaerobic environments, but is toxic and lacks specificity, can potentially serve as a delivery vehicle for ApDC. Here, we propose a synergistic therapy approach that combines the penetrative capability of bacteria with the targeting and toxic effects of ApDC by conjugating ApDC to VNP20009 through straightforward, one-step click chemistry. With this strategy, bacteria specifically target pancreatic cancer through anaerobic chemotaxis and subsequently adhere to tumor cells driven by the aptamer’s specific binding. Results indicate that this method prolongs the serum stability of ApDC up to 48 h and resulted in increased drug concentration at tumor sites compared to the free drugs group. Moreover, the aptamer’s targeted binding to cancer cells tripled bacterial colonization at the tumor site, leading to increased death of tumor cells and T cell infiltration. Notably, by integrating chemotherapy and immunotherapy, the effectiveness of the treatment is significantly enhanced, showing consistent results across various animal models. Overall, this strategy takes advantage of bacteria and ApDC and thus presents an effective synergistic strategy for pancreatic cancer treatment.
Regulation of CD8+ T cells by lipid metabolism in cancer progression
Authors: Tang Yong , Chen Ziqing , Zuo Qianying , Kang Yibin
Published: October 2024

Dysregulation of lipid metabolism is a key characteristic of the tumor microenvironment, where tumor cells utilize lipids for proliferation, survival, metastasis, and evasion of immune surveillance. Lipid metabolism has become a critical regulator of CD8+ T-cell-mediated antitumor immunity, with excess lipids in the tumor microenvironment impeding CD8+ T-cell activities. Considering the limited efficacy of immunotherapy in many solid tumors, targeting lipid metabolism to enhance CD8+ T-cell effector functions could significantly improve immunotherapy outcomes. In this review, we examine recent findings on how lipid metabolic processes, including lipid uptake, synthesis, and oxidation, regulate CD8+ T cells within tumors. We also assessed the impact of different lipids on CD8+ T-cell-mediated antitumor immunity, with a particular focus on how lipid metabolism affects mitochondrial function in tumor-infiltrating CD8+ T cells. Furthermore, as cancer is a systemic disease, we examined systemic factors linking lipid metabolism to CD8+ T-cell effector function. Finally, we summarize current therapeutic approaches that target lipid metabolism to increase antitumor immunity and enhance immunotherapy. Understanding the molecular and functional interplay between lipid metabolism and CD8+ T cells offers promising therapeutic opportunities for cancer treatment.
Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study
Authors: Chapman Fiona A. , Melville Vanessa , Godden Emily , Morrison Beth , Bruce Lorraine , Maguire Janet J. , Davenport Anthony P. , Newby David E. , Dhaun Neeraj
Published: October 2024

Chronic kidney disease (CKD) affects ~10% of the population and cardiovascular disease is its commonest complication. Despite treatment, patient outcomes remain poor and newer therapies are urgently needed. Here, we investigated the systemic and renal effects of apelin in CKD. In a randomized, double-blind, placebo-controlled, crossover study, 24 subjects (12 patients with CKD and 12 matched healthy subjects) received pyroglutamated apelin-13 ([Pyr1]apelin-13, 1 nmol/min and 30 nmol/min) or matched placebo on two separate visits. Systemic and renal hemodynamics were monitored throughout. The co-primary endpoints were change in systemic vascular resistance index and renal blood flow. Secondary endpoints were change in blood pressure, cardiac output, pulse wave velocity, glomerular filtration rate, natriuresis, free water clearance and urinary protein excretion. In both health and CKD, 30 nmol/min [Pyr1]apelin-13 reduced mean arterial pressure by ~4%, systemic vascular resistance by ~12%, and increased cardiac index by ~10%, compared to placebo (p < 0.05 for all). Both doses of [Pyr1]apelin-13 increased renal blood flow by ~15%, natriuresis by ~20% and free water clearance by ~10%, compared to placebo (p < 0.05 for all). In patients with chronic kidney disease only, glomerular filtration rate fell by ~10%, effective filtration fraction by ~5% and proteinuria by ~25% (p < 0.01 for all). Apelin has short-term cardiovascular and renal benefits in CKD. If maintained longer-term, these should improve patient outcomes. Clinical trials of long-acting oral apelin agonists are justified in CKD and other conditions with impaired salt and water balance. Registration number at www.clinicalTrials.gov: NCT03956576. Funded by Kidney Research UK.
Resilience of genetic diversity in forest trees over the Quaternary
Authors: Milesi Pascal , Kastally Chedly , Dauphin Benjamin , Cervantes Sandra , Bagnoli Francesca , Budde Katharina B. , Cavers Stephen , Fady Bruno , Faivre-Rampant Patricia , González-Martínez Santiago C. , Grivet Delphine , Gugerli Felix , Jorge Véronique , Lesur Kupin Isabelle , Ojeda Dario I. , Olsson Sanna , Opgenoorth Lars , Pinosio Sara , Plomion Christophe , Rellstab Christian , Rogier Odile , Scalabrin Simone , Scotti Ivan , Vendramin Giovanni G. , Westergren Marjana , Lascoux Martin , Pyhäjärvi Tanja ,   On behalf of the GenTree Consortium
Published: October 2024

The effect of past environmental changes on the demography and genetic diversity of natural populations remains a contentious issue and has rarely been investigated across multiple, phylogenetically distant species. Here, we perform comparative population genomic analyses and demographic inferences for seven widely distributed and ecologically contrasting European forest tree species based on concerted sampling of 164 populations across their natural ranges. For all seven species, the effective population size, Ne, increased or remained stable over many glacial cycles and up to 15 million years in the most extreme cases. Surprisingly, the drastic environmental changes associated with the Pleistocene glacial cycles have had little impact on the level of genetic diversity of dominant forest tree species, despite major shifts in their geographic ranges. Based on their trajectories of Ne over time, the seven tree species can be divided into three major groups, highlighting the importance of life history and range size in determining synchronous variation in genetic diversity over time. Altogether, our results indicate that forest trees have been able to retain their evolutionary potential over very long periods of time despite strong environmental changes.
HEV ORF2 protein-antibody complex deposits are associated with glomerulonephritis in hepatitis E with reduced immune status
Authors: Leblond Anne-Laure , Helmchen Birgit , Ankavay Maliki , Lenggenhager Daniela , Jetzer Jasna , Helmchen Fritjof , Yurtsever Hueseyin , Parrotta Rossella , Healy Marc E. , Pöschel Amiskwia , Markkanen Enni , Semmo Nasser , Ferrié Martin , Cocquerel Laurence , Seeger Harald , Hopfer Helmut , Müllhaupt Beat , Gouttenoire Jérôme , Moradpour Darius , Gaspert Ariana , Weber Achim
Published: October 2024

Hepatitis E virus (HEV) infection, one of the most common forms of hepatitis worldwide, is often associated with extrahepatic, particularly renal, manifestations. However, the underlying mechanisms are incompletely understood. Here, we report the development of a de novo immune complex-mediated glomerulonephritis (GN) in a kidney transplant recipient with chronic hepatitis E. Applying immunostaining, electron microscopy, and mass spectrometry after laser-capture microdissection, we show that GN develops in parallel with increasing glomerular deposition of a non-infectious, genome-free and non-glycosylated HEV open reading frame 2 (ORF2) capsid protein. No productive HEV infection of kidney cells is detected. Patients with acute hepatitis E display similar but less pronounced deposits. Our results establish a link between the production of HEV ORF2 protein and the development of hepatitis E-associated GN in the immunocompromised state. The formation of glomerular IgG-HEV ORF2 immune complexes discovered here provides a potential mechanistic explanation of how the hepatotropic HEV can cause variable renal manifestations. These findings directly provide a tool for etiology-based diagnosis of hepatitis E-associated GN as a distinct entity and suggest therapeutic implications.
p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injury
Authors: Kar Parmita , Sivasailam Ashok , Lavarti Rupa , Cai Lun , Thangaraju Muthusamy , Nguyen Emma , Mundluru Bhavishya , Raju Raghavan Pillai
Published: October 2024

The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse. We further show that the p21v1 response is, at least, partially independent of p53.
PTFE layer formation during brush electroplating of nickel
Authors: Isern L. , Impey S. , Almond H. , Clouser S. J. , Endrino J. L.
Published: October 2024

Brush electrodeposition of Ni/PTFE composite coatings was explored using a nickel high speed solution and polytetrafluoroethylene (PTFE) particles 6–9 μm in diameter. A novel bilayer-like, partially intercalated structure was produced, consisting of a rough nickel sublayer covered by an outer, compact, smooth PTFE layer. The study of the coating growth revealed that the PTFE particles bind together on the nickel coating valleys and grow until all the surface is covered by a polymer layer without the need of a baking stage. The resulting coating presents a hydrophobic surface with a low coefficient of friction (0.10) and higher corrosion resistance to salt spray testing than the nodular nickel coating. The coatings were produced using an aqueous nickel plating solution, where the hydrophobic PTFE particles were suspended using different substances: cetrimonium bromide (CTAB) cationic surfactant, isopropyl alcohol premixed with the particles, and ethanol premixed with the particles. High concentrations of the suspending products were detrimental for the deposition process, but optimal values of 0.1 g/l, 3 ml/l and 3 ml/l respectively were found. All compounds successfully suspended the PTFE particles and both alcohols produced the Ni/PTFE coating described before, but the CTAB failed to co-deposit the polymer.
24 Months clinical prospective of proximal restorations with repeated preheating bulk fill composite up to ten cycles: randomized controlled trial
Authors: Ibrahim Islam , Helal Heba , Ibrahim Shereen Hafez , Riad Mona
Published: October 2024

This study aimed to clinically evaluate the performance of non-preheated bulk fill resin composite in class II cavities versus one, five and ten-time preheating cycles at 68 °C. Eighty-four recruited participants were randomly allocated into four groups (21 patients per group). One posterior Bulk-fill proximal restoration was performed for each participant according to the preheating cycles where in group I; teeth were restored with non-heated resin composite, group II: One preheating cycle of composite syringe was performed prior restoration, and group III: five preheating cycles while for group IV: Ten preheating cycles were performed. These restorations were clinically evaluated at 6, 12, 18 and 24 months. Statistical analysis was performed using one way ANOVA, with set p-value < 0.05. The results revealed that there was perfect agreement between both observers and observations WK (95% CI) [0.908 (0.780:1.000)] and [0.940 (0.824:1.000)], respectively. All restorations showed acceptable clinical performance with alpha and bravo scores. No replacement was required for any restoration. No statistically significant differences were detected between the control and intervention groups across all parameters during the various evaluation stages. It could be concluded that the clinical performance of ten cycles of repeated preheated bulk fill resin composite was equivalent to that of non-preheating resin composites after 24 months follow-up period, with great improvement in manipulation. Preheating of resin composite could be performed up to ten cycles prior to placement without any clinical adverse consequences on the performance of the restoration.
Demyelination and neurodegeneration early in experimental autoimmune encephalomyelitis contribute to functional deficits in the anterior visual pathway
Authors: Sekyi Maria T. , Feri Micah , Desfor Shane , Atkinson Kelley C. , Golestany Batis , Beltran Fernando , Tiwari-Woodruff Seema K.
Published: October 2024

Impaired visual function is a prevalent feature of optic neuritis (ON) in multiple sclerosis (MS). Abnormal visual evoked potential (VEP) findings of increased latencies, reduced amplitudes and abnormal waveforms as well as decreased retinal nerve fiber layer (RNFL) assessed by optical coherence tomography (OCT) are hallmarks of ON-induced visual dysfunction. Here we utilized the experimental autoimmune encephalomyelitis (EAE) mouse model of MS to investigate the functional and pathological progression during early (before any clinical symptoms), peak (initial maximal clinical symptoms), and late (chronic disease for > 3 weeks) disease stages. Demyelination and initial stages of axon damage were observed in early EAE. Significant demyelination, inflammation, increased axon damage and impaired P1/N2 amplitudes and latencies by VEP were seen in middle and late EAE groups. A decrease in RNFL thickness by OCT was observed only during late EAE. NanoString analysis of optic nerves from late EAE indicated elevated inflammation-related genes, reduced myelin-related genes, and changes in axon degeneration-related genes. Early inflammatory demyelination and functional deficits of the visual pathway, if untreated, may lead to severe irrecoverable axon damage in EAE. These studies potentially help explain the progression of visual dysfunction during MS.
Soft X-ray spectromicroscopic proof of a reversible oxidation/reduction of microbial biofilm structures using a novel microfluidic in situ electrochemical device
Authors: Ingino Pablo , Eraky Haytham , Zhang Chunyang , Hitchcock Adam P. , Obst Martin
Published: October 2024

In situ electrochemistry on micron and submicron-sized individual particles and thin layers is a valuable, emerging tool for process understanding and optimization in a variety of scientific and technological fields such as material science, process technology, analytical chemistry, and environmental sciences. Electrochemical characterization and manipulation coupled with soft X-ray spectromicroscopy helps identify, quantify, and optimize processes in complex systems such as those with high heterogeneity in the spatial and/or temporal domain. Here we present a novel platform optimized for in situ electrochemistry with variable liquid electrolyte flow in soft X-ray scanning transmission X-ray microscopes (STXM). With four channels for fluid control and a modular design, it is suited for a wealth of experimental conditions. We demonstrate its capabilities by proving the reversible oxidation and reduction of individual microbial biofilm structures formed by microaerophilic Fe(II)-oxidizing bacteria, also known as twisted stalks. We show spectromicroscopically the heterogeneity of the redox activity on the submicron scale. Examples are also provided of electrochemical modification of liquid electrolyte species (Fe(II) and Fe(III) cyanides), and in situ studies of electrodeposited copper nanoparticles as CO2 reduction electrocatalysts under reaction conditions.
Comprehensive risk factor-based nomogram for predicting one-year mortality in patients with sepsis-associated encephalopathy
Authors: Jin Guangyong , Zhou Menglu , Chen Jiayi , Ma Buqing , Wang Jianrong , Ye Rui , Fang Chunxiao , Hu Wei , Dai Yanan
Published: October 2024

Sepsis-associated encephalopathy (SAE) is a frequent and severe complication in septic patients, characterized by diffuse brain dysfunction resulting from systemic inflammation. Accurate prediction of long-term mortality in these patients is critical for improving clinical outcomes and guiding treatment strategies. We conducted a retrospective cohort study using the MIMIC IV database to identify adult patients diagnosed with SAE. Patients were randomly divided into a training set (70%) and a validation set (30%). Least absolute shrinkage and selection operator regression and multivariate logistic regression were employed to identify significant predictors of 1-year mortality, which were then used to develop a prognostic nomogram. The model’s discrimination, calibration, and clinical utility were assessed using the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analysis, respectively. A total of 3,882 SAE patients were included in the analysis. The nomogram demonstrated strong predictive performance with AUCs of 0.881 (95% CI: 0.865, 0.896) in the training set and 0.859 (95% CI: 0.830, 0.888) in the validation set. Calibration plots indicated good agreement between predicted and observed 1-year mortality rates. The decision curve analysis showed that the nomogram provided greater net benefit across a range of threshold probabilities compared to traditional scoring systems such as Glasgow Coma Scale and Sequential Organ Failure Assessment. Our study presents a robust and clinically applicable nomogram for predicting 1-year mortality in SAE patients. This tool offers superior predictive performance compared to existing severity scoring systems and has significant potential to enhance clinical decision-making and patient management in critical care settings.
Efficacy analysis of HAIC combined with lenvatinib plus PD-1 inhibitor vs. first-line systemic chemotherapy for advanced intrahepatic cholangiocarcinoma
Authors: Lin Zhipeng , Zou Xugong , Hu Xiaolong , Huang Dabei , Chen Yuan , Lin Jiawen , Li Xiaoqun , Zhang Jian
Published: October 2024

This research was intended to compare the clinical efficacy of hepatic arterial infusion chemotherapy (HAIC) in conjunction with lenvatinib and PD-1 inhibitors to first-line systemic chemotherapy for advanced intrahepatic cholangiocarcinoma(ICC). The research enrolled advanced ICC patients who underwent HAIC plus lenvatinib and PD-1 inhibitor(n = 51) or first-line systemic chemotherapy(cisplatin + gemcitabine, n = 39) between July 2020 to January 2023 in Zhongshan People’s Hospital.Their clinical outcomes were assessed through measurement of parameters encompassing objective response rate (ORR), disease control rate (DCR), median overall survival (mOS), median progression-free survival (mPFS), median duration of response (mDOR), and treatment-related adverse events (TRAEs). In accordance with the RECIST1.1, the ORR in the HAIC + L + P and SC groups was 43.1% and 20.5%, while the DCR was 90.2% and 69.2%, respectively (P = 0.04 and = 0.02, respectively). The change in the maximum diameter of intrahepatic target lesions in patients before and after treatment and the diameter of intrahepatic tumors in the HAIC + L + P group were sharply smaller versus the SC group ( P < 0.001). The HAIC + L + P group had prolonged mOS (16.8 months vs. 11.0 months, P = 0.01) and mPFS (12.0 months vs. 6.9 months, P < 0.01) in comparison with the SC group. Compared to first-line systemic chemotherapy(cisplatin + gemcitabine), HAIC plus lenvatinib and PD-1 inhibitors contributes to improvement of tumor response and prolongation of OS and PFS in advanced ICC patients.
Association between dietary inflammatory index and all-cause mortality risk in adults with coronary heart disease in the United States
Authors: Wang Enyang , Fang Caoyang , Zhang Jing , Wang Yuqi
Published: October 2024

Diet and inflammation are crucial in the incidence and progression of coronary heart disease (CHD). This study aimed to investigate the correlation between the Dietary inflammatory index (DII) and all-cause mortality in CHD patients. A total of 1,303 CHD patients from the National Health and Nutrition Examination Survey (NHANES) between 2003 and 2018 were included. Multivariate Cox regression was used to explore the correlation between the DII and the risk of all-cause mortality in these patients. Restricted cubic spline (RCS) analysis was also utilized to examine the relationship between the DII and all-cause mortality risk in CHD patients. Additionally, subgroup analyses were conducted to determine how the correlation between the DII and all-cause mortality varied across different demographics. During a median follow-up period of 77 months among 1,303 CHD patients, 536 died from all causes. The DII scores were significantly higher in deceased patients compared to survivors. After adjusting for confounding factors, the multivariate Cox regression analysis indicated a strong positive correlation between the DII and all-cause mortality in CHD patients. RCS analysis suggested a non-linear relationship between the DII and all-cause mortality among CHD patients. Additionally, an increase in DII was more pronounced in its impact on female patients. The DII is strongly correlated with the risk of all-cause mortality among CHD patients, particularly among females. Thus, managing dietary inflammation is vital for the prevention and treatment of CHD, especially in female patients.
Quasi-two-dimensional pseudo-sessile drops
Authors: Kärki Tytti , Pääkkönen Into , Kyriakopoulos Nikos , Timonen Jaakko V. I.
Published: October 2024

Sessile drops are ubiquitous and important in technological applications. While dynamics of liquid drops have been studied under confinement, the possibility of creating sessile drops with reduced dimensionality has not been explored. Here, we demonstrate a quasi-two-dimensional (Q2D) analogy for axisymmetric sessile three-dimensional (3D) drops. The Q2D drops are created by confining liquids between parallel vertical walls, forming low aspect ratio capillary bridges deformed by gravity. Stationary Q2D drops adopt projected shapes analogous to 3D sessile drops, ranging from circular drops to puddles. When moving, the Q2D drops exhibit capillary and fluid mechanical behaviours conceptually analogous to 3D drops, including impacts and sliding. The Q2D drops also exhibit more complex phenomena such as levitation, various instabilities and pattern formation when subjected to external electric, magnetic and flow fields. The 3D-Q2D analogy suggests that the diverse and often complicated phenomena observed in 3D drops can be studied in the simplified Q2D geometry. Additionally, the Q2D confinement analogy allows exploring phenomena arising from the reduced dimensionality and the altered boundary conditions.
Unraveling autophagic imbalances and therapeutic insights in Mecp2-deficient models
Authors: Esposito Alessandro , Seri Tommaso , Breccia Martina , Indrigo Marzia , De Rocco Giuseppina , Nuzzolillo Francesca , Denti Vanna , Pappacena Francesca , Tartaglione Gaia , Serrao Simone , Paglia Giuseppe , Murru Luca , de Pretis Stefano , Cioni Jean-Michel , Landsberger Nicoletta , Guarnieri Fabrizia Claudia , Palmieri Michela
Published: October 2024

Loss-of-function mutations in MECP2 are associated to Rett syndrome (RTT), a severe neurodevelopmental disease. Mainly working as a transcriptional regulator, MeCP2 absence leads to gene expression perturbations resulting in deficits of synaptic function and neuronal activity. In addition, RTT patients and mouse models suffer from a complex metabolic syndrome, suggesting that related cellular pathways might contribute to neuropathogenesis. Along this line, autophagy is critical in sustaining developing neuron homeostasis by breaking down dysfunctional proteins, lipids, and organelles.

Here, we investigated the autophagic pathway in RTT and found reduced content of autophagic vacuoles in Mecp2 knock-out neurons. This correlates with defective lipidation of LC3B, probably caused by a deficiency of the autophagic membrane lipid phosphatidylethanolamine. The administration of the autophagy inducer trehalose recovers LC3B lipidation, autophagosomes content in knock-out neurons, and ameliorates their morphology, neuronal activity and synaptic ultrastructure. Moreover, we provide evidence for attenuation of motor and exploratory impairment in Mecp2 knock-out mice upon trehalose administration. Overall, our findings open new perspectives for neurodevelopmental disorders therapies based on the concept of autophagy modulation.
Selectively controlled synthesis of diethyl carbonate and methyl ethyl carbonate via transesterification of dimethyl carbonate over a KATriz/Al2O3 catalyst
Authors: Wang Peixue , Liu Shimin , Cui Xinjiang , Shi Feng
Published: October 2024

Effectively synthesis of methyl ethyl carbamate from dimethyl carbonate and ethanol using 14 wt% KATriz/Al2O3 in fixed bed mode.
Probe molecular diffusivity in single ternary inorganic–organic microdroplets via interfacial ozonolysis of thiosulfate
Authors: Hung Tzu-Chiao , Lin Feng-Yu , Hsu Shao-Hung , Kasai Toshio , Chang Yuan-Pin
Published: October 2024

The aqueous sodium thiosulfate microdroplets mixed with glucose or sucrose are used as model system of ternary inorganic–organic aerosols, and the RH-dependent diffusivity of thiosulfate in such system is probed via its interfacial ozonolysis.
Progress in in situ characterization of electrocatalysis
Authors: Shen Wei , Ye Yizhen , Xia Qiujin , Xi Pinxian
Published: October 2024

In situ electrochemical characterization techniques are introduced from the perspectives of multispectral resolution, space resolution and time resolution.
Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response
Authors: Arora Rajat , Mukherjee Ayan , Arthur Gilbert , Nachtigal Mark W. , Schweizer Frank
Published: October 2024

We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
Rhodium-catalyzed N-alkenylation of ketimines: one-pot synthesis of polysubstituted pyrroles
Authors: Qian Xue-Wei , Sun Xing-Wen
Published: October 2024

Herein, we report a one-pot synthesis of pyrroles via rhodium-catalyzed N-alkenylation of ketimines. This method was also applied to the efficient synthesis of the natural product Lamellarin R.
Green anti-solvent engineering for high-efficiency and environmentally friendly perovskite solar cells
Authors: Yang Yuwen , Huang Zhaolong , Gao Hao , Xu Zicong , Fang Weihong , Chen Yichuan , Hu Yuehui , Yi Zhijie , Huang Jiayu , Zhu Hua
Published: October 2024

The outstanding research achievements on green anti-solvents in recent years are summarized. Additionally, five non-anti-solvent green preparation methods prescribed by physical processes are also included.
Detection of mercury(ii) in aqueous media using bodipy-functionalized magnetic fluorescent sporopollenin
Authors: Bayrak Melike , Cimen Aysel , Bilgic Ali
Published: October 2024

Pollution from heavy metal ions has become a major issue worldwide.
The thermal behavior and pyrolysis mechanism of a polyimide gas separation membrane
Authors: Li Qinxu , Chen Bo , Yao Songyuan , Sang Chao , Lu Lu , Dong Shilong , Cao Hui , Si Zhihao , Qin Peiyong
Published: October 2024

Polyimide (PI) membranes have shown great advantages in gas separation due to their excellent thermal and chemical stability as well as high separation performance.
Advances in the application of first principles calculations to phosphate-based NASICON battery materials
Authors: Cui Zhongyi , Sun Shilong , Ning Gexuan , Liang Lisi , Wang Zeming , Qiao Jiangyu , Zhang Lixing , Chen Jin , Zhang Zhuyue
Published: October 2024

NASICON potential unlocked: first-principles calculations guide doping for sodium ion battery advancement.
Metal-ion-coordinated cross-linked quasi-solid-state polymer electrolyte for a high energy-density and long-life Prussian blue analogs cathode
Authors: Wang Xinyu , Yang Cheng , Jiang Ning , Wang Yichao , Sun Shouyu , Liu Yu
Published: October 2024

Utilizing a thermal polymerization method, the as-designed polymer electrolyte possesses faster ion transport and more superior interfacial stability, effectively inhibiting the transition metals dissolution and prolonging battery lifespan.
Donor incomplete ionization and mobility enhancement in ultra-thin silicon-on-insulator films doped by phosphorus end-terminated polymers
Authors: Pulici Andrea , Kuschlan Stefano , Seguini Gabriele , De Michielis Marco , Chiarcos Riccardo , Laus Michele , Fanciulli Marco , Perego Michele
Published: October 2024

The injection of P atoms is studied confining the same P dose in a progressively thinner silicon-on-insulator film. To account for the incomplete ionization observed in ultra-thin samples, the effect of Si/SiO2 interfaces must be considered.
A facile membraneless method for detecting alkali-metal cations using organic electrochemical transistors
Authors: He Waner , Kashino Yurika , Nozaki Naoya , Kimpel Joost , Matsumoto Hidetoshi , Hayamizu Yuhei , Michinobu Tsuyoshi
Published: October 2024

A facile membraneless method for detecting alkali-metal cations was developed by adding ionophores (crown ethers: 18C6 or 15C5) to a polymer matrix (p(g2T-TT)) as the active layer in organic electrochemical transistors.
Polarization-dependent plasmon coupling between Au nanorods and Au nanospheres in core–satellite nanoassemblies
Authors: Jeong Ina , Yun Seokhyun , Yoon Sangwoon
Published: October 2024

For AuNR@AuNS core@satellite assemblies, longitudinal plasmon coupling is selectively induced by light polarized along the long axis while transverse plasmon coupling does not exhibit a strong preference for polarization in the transverse direction.
High‐speed algorithm for fault detection and location in DC microgrids based on a novel time–frequency analysis
Authors: Poursaeed Amir Hossein , Namdari Farhad
Published: October 2024

Protecting DC microgrids (DCMGs) from faults is critical due to the rapid current changes that occur in milliseconds. However, ensuring fast and accurate protection in DCMGs is more challenging than in AC systems. This study proposes a novel protection algorithm using traveling waves (TWs) for fault detection and localization. The high‐order synchrosqueezing transform (FSSTH) is applied to precisely identify TWs at the relay location. FSSTH offers a sharp time–frequency representation, enhancing the accuracy and speed of fault detection. This method can accurately detect transient phenomena like TWs in DCMGs, even with noise and variable fault resistance. By using the spectral envelope with FSSTH, ridges in time–frequency representations are extracted, improving fault diagnosis. The approach differentiates external from internal faults and recognizes fault direction by assessing TW polarity. Testing on two different DCMGs showed this algorithm's high efficiency and accuracy, with fault location errors ranging from 1 to 50 meters in low‐voltage and 13 to 64 meters in medium‐voltage DCMGs, even under challenging conditions like high resistance (up to 500 Ω) and low signal‐to‐noise ratio (5 dB). These results demonstrate the method's superior accuracy and robustness compared to existing techniques.
Design and implementation of a solar power optimizer for module level power electronics application
Authors: Allahverdinejad Babak , Ajami Ali , Banaei Mohamad Reza
Published: October 2024

Partial shading on series‐connected photovoltaic (PV) panels in conventional PV systems results in lower harvested power. To resolve this, it is vital to utilize module level power electronics (MLPE) such as Solar Power Optimizers (SPOs). This paper introduced a non‐isolated common ground non‐inverting output voltage buck‐boost converter as an SPO. Proposed converter benefits from continuous input and output currents which has a significant role in designing SPOs. Having a quadratic gain, beside acceptable step‐down range are other features of the converter. Operating principle, design, steady‐state, small‐signal analysis, and dynamic performance of proposed converter are included. Proposed converter is compared with other buck‐boost converters in terms of voltage gain, voltage stresses, continuous input and output current, and output polarity. To validate the performance of introduced converter, experimental results for a prototype with input voltage 24 V, output voltage 72 V for step‐up and 15 V for step‐down modes are given and results are examined. The maximum efficiency of the prototype is 93% and 89% for step‐up and step‐down modes, respectively. To evaluate the effect of proposed SPO for extracting maximum available power from PVs, simulation results of a grid connected PV system with two series connected SPOs is discussed.
Retraction Note: Analyzing the economic value of BIM technology in urban real estate adjudication through Meta
Authors: Yuhao Jiang , Nikolayevich Kovshar Sergey , Holubava Volha
Published: October 2024

This article has been retracted because it substantially reflects the content and analysis of the following original article, without reference to it:

Jafary, P., Shojaei, D., Rajabifard, A., Ngo, T., 2024. BIM and real estate valuation: challenges, potentials and lessons for future directions. Engineering, Construction and Architectural Management 31, 1642-1677. https://doi.org/10.1108/ECAM-07-2022-0642

Retraction approved by the Editor and the Publisher on October 10, 2024.
Boiling Heat Transfer On Biphilic Surfaces With Arrays Of Grooves
Authors: Vladimirov Victor , Khmel Sergey , Chinnov Evgeny
Published: October 2024

Experiments were carried out on biphilic surfaces made using technology consisted in the deposition (105℃) of fluorinated methoxysilane on a copper surface with arrays of grooves preliminarily created by laser ablation, as a result of which deposition the grooves became superhydrophobic. Grooves were two types: parallel grooves and groove lattice. Size of grooves was 30-43 um, pitch for parallel grooves was 1-1,5 mm and for grove lattice – 1 mm. The experiments were carried out on distilled water at atmospheric pressure. For all surfaces, a significant intensification of heat transfer has been achieved, compared with a smooth copper surface. It was shown, that boiling heat transfer depend only from pitch between grooves for both types of grooves. Dependence of heat transfer coefficient from size of grooves was not observed. Most efficient type of surfaces was groove lattice with smallest pitch.
Modelling of hydrofracturing experiments of granite samples
Authors: Lapin Vasily , Stanchits Sergey , Filev Egor
Published: October 2024

Based on laboratory experiments and numerical modelling, the propagation of hydraulic fracturing fractures in cylindrical granite samples caused by viscous fluid pumping is described. Comparison of simulation results and laboratory measurements show that the fracture hydraulic resistance much greater than the one predicted by the cubic law that is usually used in hydraulic fracture models. If this hydraulic resistance is not taken into account, the pressure, volume and speed of fracture propagation are predicted incorrectly. It is shown that additional hydraulic resistance can be caused by the fracture walls roughness and can be taken into account by velocity correction factor.
Measurement of the nucleation density during non-stationary boiling of water
Authors: Levin A. , Khan P.
Published: October 2024

An experimental study of the boiling characteristics of water heated to saturation temperature under pulsed heating of a cylindrical metal surface with a roughness up to 5 microns was carried out. The experiments were conducted for a range of initial liquid temperatures from 30 to 110 °C, initial pressures of 0.3 MPa, water velocities of 0.4 m/s, and wall temperature rises of 200 to 1900 K/sec. The nucleation density was determined during the development of bubble boiling at different levels of power release and initial temperatures of the liquid.
Drying microcharacteristics of volatile and non-volatile droplets on smooth and structured surfaces
Authors: Peschenyuk Yulia A. , Ayvazyan Gagik Y. , Gatapova Elizaveta Ya.
Published: October 2024

In order to analyze the dynamics of droplet evaporation from solid surfaces and to study the liquid-solid interactions, liquid droplets were deposited on substrates and examined under a microscope. Due to the variation of interfacial tensions at liquid-gas and at liquid-solid the contact line changes depending on the type of solid surface and liquid. In this study, two liquids with different surface tensions (water and ethanol) are employed to examine the effects of evaporation time and to elucidate the underlying mechanisms of solid-liquid interactions. In the case of rapidly evaporating ethanol droplets, the formation of residual droplets and internal currents was observed. In contrast, the evaporation of water droplets resulted in only a change in the shape of the contact line. The paper presents a dependence of the Ohnesorge number on the dimensionless diameter, which characterizes all the considered types of interaction. Additionally, an analysis of the contact angle and contact diameter is presented.
Supervision und Balintarbeit – eine vergleichende
Skizze
Authors: Grawe Bernadette
Published: October 2024

Balint-Gruppenarbeit und Supervision sind verwandte Beratungsformate mit
Gemeinsamkeiten, aber auch mit klaren Unterschieden. In diesem Beitrag
verdeutlicht zunächst ein historischer Rückblick ihrer beider
Entstehungsgeschichte und sieht die zentrale Gemeinsamkeit in der
Professionalität der jeweiligen Beratungsbeziehung. Nach begrifflichen Klärungen
erläutert ein Fallbeispiel die Unterschiede. Während der primäre Gegenstand von
Balint-Gruppenarbeit die Reflexion von professionellen Beziehungen und ihren
unbewussten Verstrickungen darstellt, ist der Gegenstand von Supervision
mehrdimensional, da sie in einer Fallbearbeitung immer das Zusammenspiel
zwischen der Person, ihrer Rolle, der Organisation und der Klientel in den Blick
nimmt und aufklären will.
Das „Flash“-Phänomen und die Semiotik: Die „Droge Arzt“ als
intersubjektiver Zeichenprozess
Authors: Herzog Philipp
Published: October 2024

Michael und Enid Balint haben in ihrer Forschungsarbeit mit Hausärzten sehr bald
erkannt, dass das am häufigsten verordnete Medikament der Arzt selber ist. Ihre
Entdeckung des „Flash“-Phänomens führte zu einem grundlegend neuen Verständnis
der Wirkmacht der Arzt-Patient-Beziehung. Der Begriff beschreibt metaphorisch
das blitzartige, intuitive, gegenseitige Verstehen von Arzt und Patient. Obwohl
die Effekte der „Droge Arzt“ und des „Flash“ im Rahmen der Balint-Arbeit nicht
in Zweifel gezogen werden, bleibt der eigentliche Vorgang hinter Oberfläche des
Geschehens auch nach Jahrzehnten unklar. Diese Arbeit gibt eine kurze Einführung
in die die Semiotik und wendet sie auf zwei exemplarische Fallbeispiele aus der
Praxis an, um sie in ihrer kommunikativen Mikrostruktur zu erfassen und die
definitorische Unschärfe, die den Begriffen „Droge Arzt“ und „Flash“ innewohnt,
zu präzisieren.
Balint im Betrieb
Authors: Hölzer Michael
Published: October 2024

Dass Arbeit unter bestimmten Bedingungen krank macht, gilt als empirisch
erwiesen. Hinweise, dass dabei das Verhalten von Führungskräften eine
entscheidende Rolle spielt, finden sich zuhauf in der einschlägigen Literatur.
Die von einer Arbeitsgruppe erarbeiteten Modalitäten einer nach der
Balintmethode konzipierten Führungskräfte-Werkstatt soll in einer von Zahlen,
Daten und Fakten geprägten Welt der Wirtschaft den teilnehmenden Führungskräften
Subjektivität und Empathie schulen, um mit einem beziehungsorientierten
Führungsstil in einem immer sich ständig beschleunigendem Arbeitsalltag
gesundheitlichen Gefahren ihrer Mitarbeitenden vorbeugen.
Pancreatic ultrasound: An update of measurements, reference values,
and variations of the pancreas
Authors: Meier Jennifer , Lucius Claudia , Möller Kathleen , Jenssen Christian , Zervides Constantinos , Gschmack Anna Maria , Dong Yi , Srivastava David , Dietrich Christoph F.
Published: October 2024

Reliable and reproducible measurement methods have been established, and
reference values are used in almost all scientific disciplines. Knowledge of
reference values is crucial to distinguish physiological from pathological
processes and, therefore, subsequently, for the clinical management of patients.
Image storage and documentation of measurements and normal findings should be
part of quality assurance in imaging. This paper aims to review the published
literature and provide current knowledge of sonographic measurements and
reference values of the pancreas. Moreover, the role of clinical influencing
factors such as age, gender, constitution, and ethnicity is also analyzed.
Transorbital Endoscopic Approach for Managing Challenging Frontal Sinus Lesions: Results and Operative Technique Description
Authors: Yasuda Marcos Ezequiel , Mastrolonardo Alexander , Nguyen Thomas , Moore Jessy , Sommer Doron D. , Reddy Kesava
Published: October 2024

Objective The aim of this study was to describe our experience using the transorbital endoscopic approach (TEA) in the frontal sinus and the step-by-step technique used.

Materials and Methods We reviewed the charts from adult patients who underwent management of frontal sinus lesions with TEA performed from 2017 to 2022.

Results Seven patients underwent eight surgeries for frontal sinus lesions using TEA in combination with the endoscopic transnasal approach (ETA), with the majority on the left side (5/8, 62.5%). The average age was 53.9 years, with six male patients and one female patient. Gross total resection (GTR) was achieved in all cases. The most common symptoms leading to surgery were headaches or a sensation of pressure in the forehead (5/8, 62.5%), followed by a decreased sense of smell (3/8, 37.5%), diplopia (3/8, 37.5%), proptosis (2/8, 20%), periorbital cellulitis (2/8, 20%), and decreased visual acuity (1/8, 12.5%). The most common etiology in this case series was mucocele (5/8, 62.5%), followed by osteoid osteoma (2/8, 20%), and inverted papilloma (1/8, 12.5%). The length of stay in all cases was 1 day. The most common complication was mild and transitory V1 numbness, which fully recovered after 6 months (5/8, 62.5%). The average follow-up period was 24.6 months (range of 3–48 months).

Conclusion Transoral Endoscopic Approach (TEA) demonstrated being a valuable complement to ETA approaches for treating frontal sinus lesions, especially in challenging regions. The transorbital approach is feasible and can safely achieve GTR for a variety of pathologies while effectively controlling symptoms and resulting in a 1-day hospital stay.
Nitrogen-Centered Radicals in Visible-Light-Promoted Reactions
Authors: Franco Francesca , Boselli Monica F. , Medici Fabrizio
Published: October 2024

Nitrogen-centered radicals (NCRs) have been known in the literature since the beginning of the 1900s, but only with the spread of photoredox catalysis, and in particular visible-light-mediated radical processes, has nitrogen-radical chemistry become more accessible via the in situ generation of such radicals under mild conditions. Historically, unlike their carbon counterparts, nitrogen radicals were not utilized widely in academia or industry due to a lack of efficient strategies for their production. Nowadays, NCRs are more established, and this graphical review highlights key publications from the literature, categorizing them by both the type of NCR and the type of reaction. Such nitrogen radicals can be divided into four different categories according to their electronic configuration, orbital structure and chemical behavior. Additionally, the reactivity of these radicals is mostly exploited via four main types of process: (i) intramolecular cyclization, (ii) intramolecular hydrogen atom abstraction, (iii) Norrish type I fragmentation, and (iv) intermolecular addition to π systems.
Novel dopant-free ferromagnetic Mott-like insulator and high-energy correlated-plasmons in unconventional strongly correlated s band of low-dimensional gold
Authors: Naradipa Muhammad Avicenna , Fauzi Angga Dito , Ong Bin Leong , Majidi Muhammad Aziz , Diao Caozheng , Omar Ganesh Ji , Ariando Ariando , Breese Mark B. H. , Tok Eng Soon , Rusydi Andrivo
Published: October 2024

Ferromagnetic insulators and plasmons have attracted a lot of interest due to their rich fundamental science and applications. Recent research efforts have been made to find dopant-free ferromagnetic insulators and unconventional plasmons independently both in strongly correlated electron systems. However, our understanding of them is still lacking. Existing dopant-free ferromagnetic insulator materials are mostly limited to complex d- or f-systems with extremely low Curie temperature, low-symmetry structure, and strict growth conditions on specific substrates, limiting their compatibility with industrial applications. Unconventional plasmon is, on the other hand, a quasiparticle that originates from the collective excitation of correlated-charges, yet they are rarely explored, particularly in ferromagnetic insulator materials. Herewith, we present a novel, room temperature dopant-free ferromagnetic Mott-like insulator with a high-symmetry structure in unconventional strongly correlated s band of low-dimensional highly oriented single-crystal gold quantum dots (HOSG-QDs) on MgO(001). Interestingly, HOSG-QDs show new high-energy correlated-plasmons with low-plasmonics-loss. With a series of state-of-the-art experimental techniques, we find that the Mott-insulating state is tunable with surprisingly strong spin-splitting and spin polarization accompanied by strong s–s transitions, disappearance of Drude response, and generating new Mott-like gap. Supported with a series of theoretical calculations, the interplay of quantum confinement, many-body electronic correlations, and hybridizations tunes electron–electron correlations in s band and determines the ferromagnetism, Mott-like insulator, and high-energy correlated-plasmons. Our result shows a new class of room temperature dopant-free ferromagnetic Mott-like insulator and high-energy correlated-plasmons with low-loss in strongly correlated s band and opens unexplored applications of low-dimensional gold in spin field-effect transistors and plasmonics.