bluuebunny/crossref_metadata_2025 huggingface dataset:
Engineered FGF19ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model
Authors: Shi Lu , Zhao Tiantian , Huang Lei , Pan Xiaomin , Wu Tianzhen , Feng Xin , Chen Taoli , Wu Jiamin , Niu Jianlou
Published: October 2023

Background

The major safety concern of the clinical application of wild type FGF19 (FGF19WT) emerges given that its extended treatment causes hepatocellular carcinoma. Therefore, we previously generated a safer FGF19 variant - FGF19ΔKLB, which have same effects on glycemic control and bile acid production but much less mitogenic activity. However, it remains unclear as to whether FGF19ΔKLB ameliorates intrahepatic cholestasis.

Results

We found that, similar to that of FGF19WT, the chronic administration of FGF19ΔKLB protects mice from cholestatic liver injury in these two models. The therapeutic benefits of FGF19ΔKLB on cholestatic liver damage are attributable, according to the following mechanistic investigation, to the reduction of BA production, liver inflammation, and fibrosis. More importantly, FGF19ΔKLB did not induce any tumorigenesis effects during its prolonged treatment.

Conclusions

Together, our findings raise hope that FGF19ΔKLB may represent a useful therapeutic strategy for the treatment of intrahepatic cholestasis.
Impact of the adjacent bone on pseudarthrosis in mandibular reconstruction with fibula free flaps
Authors: Steffen Claudius , Soares Ana Prates , Heintzelmann Thelma , Fischer Heilwig , Voss Jan Oliver , Nahles Susanne , Wüster Jonas , Koerdt Steffen , Heiland Max , Rendenbach Carsten
Published: October 2023

Background

Mechanical and morphological factors have both been described to influence the rate of pseudarthrosis in mandibular reconstruction. By minimizing mechanical confounders, the present study aims to evaluate the impact of bone origin at the intersegmental gap on osseous union.

Methods

Patients were screened retrospectively for undergoing multi-segment fibula free flap reconstruction of the mandible including the anterior part of the mandible and osteosynthesis using patient-specific 3D-printed titanium reconstruction plates. Percentage changes in bone volume and width at the bone interface between the fibula/fibula and fibula/mandible at the anterior intersegmental gaps within the same patient were determined using cone-beam computed tomography (CBCT). Additionally, representative samples of the intersegmental zones were assessed histologically and using micro-computed tomography (µCT).

Results

The bone interface (p = 0.223) did not significantly impact the change in bone volume at the intersegmental gap. Radiotherapy (p < 0.001), time between CBCT scans (p = 0.006) and wound healing disorders (p = 0.005) were independent risk factors for osseous non-union. Preliminary analysis of the microstructure of the intersegmental bone did not indicate morphological differences between fibula–fibula and fibula–mandible intersegmental bones.

Conclusions

The bone interface at the intersegmental gap in mandibular reconstruction did not influence long-term bone healing significantly. Mechanical and clinical properties seem to be more relevant for surgical success.
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress
Authors: Uekawa Ken , Hattori Yorito , Ahn Sung Ji , Seo James , Casey Nicole , Anfray Antoine , Zhou Ping , Luo Wenjie , Anrather Josef , Park Laibaik , Iadecola Costantino
Published: October 2023

Background

Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also observed in the general population. Vascular oxidative stress and neurovascular dysfunction have been implicated in CAA but the cellular source of reactive oxygen species (ROS) and related signaling mechanisms remain unclear. We tested the hypothesis that brain border-associated macrophages (BAM), yolk sac-derived myeloid cells closely apposed to parenchymal and leptomeningeal blood vessels, are the source of radicals through the Aβ-binding innate immunity receptor CD36, leading to neurovascular dysfunction, CAA, and cognitive impairment.

Methods

Tg2576 mice and WT littermates were transplanted with CD36−/−or CD36+/+bone marrow at 12-month of age and tested at 15 months. This approach enables the repopulation of perivascular and leptomeningeal compartments with CD36−/−BAM. Neurovascular function was tested in anesthetized mice equipped with a cranial window in which cerebral blood flow was monitored by laser-Doppler flowmetry. Amyloid pathology and cognitive function were also examined.

Results

The increase in blood flow evoked by whisker stimulation (functional hyperemia) or by endothelial and smooth muscle vasoactivity was markedly attenuated in WT → Tg2576 chimeras but was fully restored in CD36−/− → Tg2576 chimeras, in which BAM ROS production was suppressed. CAA-associated Aβ1-40, but not Aβ1-42, was reduced in CD36−/− → Tg2576 chimeras. Similarly, CAA, but not parenchymal plaques, was reduced in CD36−/− → Tg2576 chimeras. These beneficial vascular effects were associated with cognitive improvement. Finally, CD36−/−mice were able to more efficiently clear exogenous Aβ1-40injected into the neocortex or the striatum.

Conclusions

CD36 deletion in BAM suppresses ROS production and rescues the neurovascular dysfunction and damage induced by Aβ. CD36 deletion in BAM also reduced brain Aβ1-40and ameliorated CAA without affecting parenchyma plaques. Lack of CD36 enhanced the vascular clearance of exogenous Aβ. Restoration of neurovascular function and attenuation of CAA resulted in a near complete rescue of cognitive function. Collectively, these data implicate brain BAM in the pathogenesis of CAA and raise the possibility that targeting BAM CD36 is beneficial in CAA and other conditions associated with vascular Aβ deposition and damage.

Graphical Abstract
Delirium and neuropsychological recovery among emergency general surgery survivors (DANE): study protocol for a randomized controlled trial and collaborative care intervention
Authors: Mohanty Sanjay , Holler Emma , Ortiz Damaris , Meagher Ashley , Perkins Anthony , Bylund Peggy , Khan Babar , Unverzagt Frederick , Xu Hupuing , Ingraham Angela , Boustani Malaz , Zarzaur Ben
Published: October 2023

Background

Delirium is a complex neuropsychiatric syndrome which consists of acute and varying changes in cognition and consciousness. Patients who develop delirium are at increased risk for a constellation of physical, cognitive, and psychological disabilities long after the delirium has ended. Collaborative care models integrating primary and specialty care in order to address patients with complex biopsychosocial needs have been demonstrated to improve outcomes in patients with chronic diseases. The purpose of this study is to evaluate the ability of a collaborative care model on the neuropsychologic recovery of delirium survivors following emergency surgery.

Methods

This protocol describes a multicenter (eight hospitals in three states) randomized controlled trial in which 528 patients who develop delirium following emergency surgery will be randomized to either a collaborative care model or usual care. The efficacy of the collaborative care model on cognitive, physical, and psychological recovery in these delirium survivors will then be evaluated over 18 months.

Discussion

This will be among the first randomized clinical trials in postoperative delirium survivors evaluating an intervention designed to mitigate the downstream effects of delirium and improve the neuropsychologic recovery after surgery. We hope that the results of this study will add to and inform strategies to improve postoperative recovery in this patient group.

Trial registration

ClinicalTrials.gov NCT05373017. Registered on May 12, 2022.
Trends and future projections of liver cancer incidence in Hong Kong: a population-based study
Authors: Ma Tianyou , Wei Xiaohui , Wu Xiaoming , Du Jianqiang
Published: October 2023

Background

Liver cancer remains a significant burden in Hong Kong. We sought to examine trends in liver cancer incidence using 30 years of cancer registry data in Hong Kong. Additionally, we aimed to assess the impact of age, period and birth cohort on liver cancer incidence, provided projections for liver cancer incidence until 2030, and examined the drivers of liver cancer incidence.

Methods

Data on liver cancer incidence were collected from the Hong Kong Cancer Registry (HKCaR). We assessed age, period, and birth cohort effects using age-period-cohort (APC) models. We employed Bayesian APC analysis with integrated nested Laplace approximations to project the future burden of liver cancer in Hong Kong. Furthermore, we attributed the changes in new liver cancer cases to population growth, population ageing, and epidemiological changes.

Results

The study included a total of 51,333 individuals, of whom 39,287 (76.53%) were male. From 1991 to 2020, the age-standardized liver cancer incidence rate in Hong Kong continued declining, while the number of new cases increased significantly, especially among males. The net drift, representing the overall annual percentage change of the age-adjusted rate, was − 3.06% (95% confidence interval [CI]: -3.31% to -2.80%) for males and − 3.85% (95% CI: -4.61% to -3.09%) for females. Local drift, which estimates the annual percentage change over time specific to age group, decreased in all age groups for both sexes, with a more pronounced decrease in younger age groups. The period and cohort risk of developing liver cancer also showed decreasing trends for both sexes. The study projected a decline in liver cancer cases for males but an increase for females in Hong Kong, with an estimated 1,083 cases in males and 710 cases in females by 2030. Demographic decomposition analysis revealed that while population growth and ageing were the main drivers of increased liver cancer cases, epidemiologic shifts mostly offset these factors.

Conclusion

The period and cohort risk of developing liver cancer in Hong Kong declined due to epidemiological changes. Although the age-standardized incidence rates of liver cancer have also declined, demographic and epidemiological factors have led to lower case expectations in males but a likely increase in females. Further research and epidemiological assessment of the disease are needed.
Evaluation of the fate of trace organic compounds using the Level III fugacity model: a case study of Rajbandh open dump site in Khulna City of Bangladesh
Authors: Pangkaj K. M. , Rafizul I. M. , Kraft E. , Berner S.
Published: October 2023

Khulna is the 3rd largest city corporation in Bangladesh that produces 450 tons of Municipal solid waste (MSW) per day and dumps the waste in the Rajbandh open dump site. The main focus of this study is to determine the fate of chemicals in different environmental media at the Rajbandh open dump site. To accomplish the aim Level III fugacity model was evaluated which is subject to steady-state partitioning, reaction, advection, and intercompartmental transfer in an evaluative environment consisting of three compartments landfill gas (LFG), leachate, and waste. In this study, the model was implemented for six chemicals Trichloroethylene, Mono-chlorobenzene, 1,4-dichlorobenzene, 1,2,4-trichlorobenzene, Hexachlorobenzene, and Benzene having different physiochemical properties. The result reveals that Benzene was found with the highest fugacity value of 2.03E + 00 Pa in all compartments while Hexachlorobenzene shows the highest value of concentration 2.67E-01 mol/m3 in the waste compartment. Regarding mass distribution, all chemical shows a higher mass remaining in the waste compartment in comparison with the other compartment. The result also reveals that the dominating removal process of a chemical from the system is the reaction process. For all the chemicals almost all the mass is removed from the environment by reaction process rather than advection in LFG and leachate. Finally, the estimated behavior of the selected chemical will help to evaluate the health and ecological hazards at the open dump site and take necessary steps to control the emission of such hazardous chemicals from the open dump site by the authority.
Monitoring of equatorial plasma bubbles using aeronautical navigation system: a feasibility study
Authors: Hosokawa Keisuke , Saito Susumu , Nakata Hiroyuki , Lin Chien-Hung , Lin Jia-Ting , Supnithi Pornchai , Tomizawa Ichiro , Sakai Jun , Takahashi Toru , Tsugawa Takuya , Nishioka Michi , Ishii Mamoru
Published: October 2023

It has long been known that field-aligned irregularities within equatorial plasma bubbles (EPBs) can cause long-range propagation of radio waves in the VHF frequencies such as those used for TV broadcasting through the so-called forward scattering process. However, no attempt has been made to use such anomalous propagations of VHF radio waves for wide-area monitoring of EPBs. In this study, we investigated the feasibility of monitoring of EPBs using VHF radio waves used for aeronautical navigation systems such as VHF Omnidirectional radio Range (VOR). There are 370 VOR stations in the Eastern and Southeastern Asian region that can be potentially used as Tx stations for the observations of anomalous propagation. We have examined the forward scattering conditions of VHF waves using the magnetic field model and confirmed that it is possible to observe the EPB-related anomalous propagation if we set up Rx stations in Okinawa (Japan), Taiwan, and Thailand. During test observations conducted in Okinawa since 2021, no signal has been received that was clearly caused by anomalous propagation due to EPBs. This is simply because EPBs have not developed to high latitudes during the observation period due to the low solar activity. In March 2023, however, possible indications of EPB-related scattering were detected in Okinawa which implies the feasibility of observing EPBs with the current observation system. We plan to conduct pilot observations in Taiwan and Thailand in future to further evaluate the feasibility of this monitoring technique.

Graphical Abstract
Percutaneous core-needle biopsy before and immediately after coaxial microwave ablation in solid non-small cell lung cancer: the comparison of genomic testing from specimens
Authors: Xu Sheng , He Lei , Qi Jing , Kong Fan-Lei , Bie Zhi-Xin , Li Yuan-Ming , Wang Zheng , Li Xiao-Guang
Published: October 2023

Purpose

To compare the genomic testing based on specimens obtained from percutaneous core-needle biopsy (CNB) before and immediately after coaxial microwave ablation (MWA) in solid non-small cell lung cancer (NSCLC), and to investigate the diagnostic performance of CNB immediately after coaxial MWA in solid NSCLC.

Methods

Coaxial MWA and CNB were performed for NSCLC patients, with a power of 30 or 40 watts (W) in MWA between the pre- and post-ablation CNB, followed by continuous ablation after the second CNB on demand. The paired specimens derived from the same patient were compared for pathological diagnosis and genomic testing. DNA/RNA extracted from the paired specimens were also compared.

Results

A total of 33 NSCLC patients with solid lesions were included. There were two patients (6.1%) without atypical cells and three patients (9.1%) who had the technical failure of genomic testing in post-ablation CNB. The concordance rate of pathological diagnosis between the twice CNB was 93.9% (kappa = 0.852), while that of genomic testing was 90.9% (kappa = 0.891). For the comparisons of DNA/RNA extracted from pre- and post-ablation CNB in 30 patients, no significant difference was found when the MWA between twice CNB has a power of 30 or 40 W and ablation time within five minutes (P = 0.174).

Conclusions

If the pre-ablation CNB presented with a high risk of pneumothorax or hemorrhage, the post-ablation CNB could be performed to achieve accurate pathological diagnosis and genomic testing and the maximum effect of ablation, which might allow for the diagnosis of genomic testing in 90.9% of solid NSCLC.
Intervention Nonadherence in the TrACER (S1415CD) Study: A Pragmatic Randomized Trial of a Standardized Order Entry for CSF Prescribing
Authors: Hershman Dawn L. , Bansal Aasthaa , Barlow William E. , Arnold Kathryn B. , Watabayashi Kate , Bell-Brown Ari , Sullivan Sean D. , Lyman Gary H. , Ramsey Scott D.
Published: October 2023

In this pragmatic trial aimed at improving CSF prescribing, there was substantial variability in site adherence to the intervention assignment.
Η κατοικία στην προανακτορική Κρήτη
Authors: Σοφιανός Γεώργιος
Published: October 2023

Η παρούσα διατριβή εξέτασε την οικιστική αρχιτεκτονική της προανακτορικής Κρήτης. Οι στόχοι ήταν τρεις. Πρώτον, μία νέα σύνθεση της εξέλιξης της προανακτορικής αρχιτεκτονικής. Δεύτερον, ο καθορισμός του κοινωνικού ρόλου της. Τρίτον, η αξιολόγηση της συμβολής της στο ανακτορικό φαινόμενο. Αφορμή αποτέλεσε η απουσία μίας μελέτης η οποία να συνεξετάζει τα προανακτορικά αρχιτεκτονικά κατάλοιπα. Το διαθέσιμο αρχιτεκτονικό υλικό, το οποίο ύστερα και από τις πρόσφατες ανασκαφικές έρευνες εμπλουτίστηκε σε μεγάλο βαθμό, δεν είχε αξιολογηθεί συνολικά στη μελέτη για την κοινωνική και ιστορική εξέλιξη του νησιού κατά την Προανακτορική περίοδο και την πορεία προς τα ανάκτορα. Η παρούσα διατριβή έκρινε σκόπιμη την αποστασιοποίηση από την τυπολογική και μορφολογική προσέγγιση διότι μέχρι σήμερα δεν είχε αποδώσει καρπούς. Θεώρησε ότι τα προανακτορικά αρχιτεκτονικά κατάλοιπα μπορούν να προσεγγιστούν καλύτερα από άποψη σχεδιασμού εξαιτίας πρώτον της σημαντικής μορφολογικής ετερογένειάς τους και δεύτερον της αποσπασματικότητας που τα χαρακτηρίζει σε αρκετές περιπτώσεις. Η παρούσα διατριβή απέδειξε ότι η προανακτορική αρχιτεκτονική μπορεί να αποτελείται από κτήρια ποικίλης μορφής που σε πρώτο επίπεδο δείχνουν διαφορετικά, ωστόσο αυτά συγκροτούνται από επιμέρους χώρους με κοινές οργανωτικές αρχές. Επιπλέον, διαπιστώθηκε ότι διέθετε σαφή χαρακτηριστικά στη διαχρονική εξέλιξη και τη γεωγραφική διασπορά αυτών των οργανωτικών αρχών της. Εν τέλει, η προανακτορική αρχιτεκτονική αποτελεί μία ακόμα διακριτή μορφή υλικού πολιτισμού της προανακτορικής Κρήτης. Με τη διαπίστωση αυτή δεν εννοείται απλώς ένα σύνολο ανθρώπινων δημιουργημάτων με κοινά μορφολογικά χαρακτηριστικά, αλλά ένα ακόμη υλικό μέσο και ταυτόχρονα αποτέλεσμα της κοινωνικής διάδρασης σε συγκεκριμένο γεωγραφικό, χρονικό και ιστορικό πλαίσιο. Επιπλέον, τέθηκε ξανά στο επίκεντρο η ύπαρξη και η σημασία ενός προανακτορικού οικιστικού πεδίου συνολικά. Κύριο συμπέρασμα της παρούσας διατριβής ήταν ότι στην προανακτορική Κρήτη υπήρχε κοινή πολιτισμική συναντίληψη στην οργάνωση του χώρου των οικημάτων και εν τέλει στον γενικότερο σχεδιασμό των οικισμών. Η άποψη αυτή ως ένα βαθμό τροποποιεί την ισχύουσα εικόνα του νησιού ως συνόλου κατακερματισμένων κοινοτήτων. Τέλος, το μινωικό ανάκτορο μπορεί να τοποθετηθεί στη γενεαλογία της μινωικής αρχιτεκτονικής ύστερα από τις προανακτορικές κοινότητες, το αρχιτεκτονικό περιβάλλον των οποίων, συνιστούσε χώρο κοινωνικής συναναστροφής και τελικά ενδυνάμωσης ενός «μινωικού έθους».
Incorporating decision-makers' perspectives into DEA models by means of weight restrictions
Authors: Γκουβίτσος Ιωάννης
Published: October 2023

Η παρούσα διατριβή ασχολείται με ένα ιδιαιτέρως σημαντικό ζήτημα στο πεδίο της Επιχειρησιακής Έρευνας, και συγκεκριμένα στην εκτίμηση της αποδοτικότητας μονάδων, με χρήση της μεθόδου Data Envelopment Analysis. Ειδικότερα, ερευνούμε την χρήση περιορισμών στους συντελεστές βαρύτητας (weight restrictions) και πώς αυτοί δύνανται να χρησιμοποιηθούν ως μέσο ενσωμάτωσης διοικητικών αποφάσεων, προτεραιοτήτων ή άλλων κρίσεων στα μοντέλα εκτίμησης της αποδοτικότητας. Η διατριβή αποτελείται από δύο ξεχωριστά δοκίμια, τα οποία διερευνούν την χρήση περιορισμών στους συντελεστές βαρύτητας (weight restrictions), σε διαφορετικό πλαίσιο, με γνώμονα πάντα την παροχή ευελιξίας στους υπεύθυνους λήψης αποφάσεων, αναφορικά με το προσδιορισμό των συντελεστών βαρύτητας. Το πρώτο μέρος προτείνει ένα νέο μεθοδολογικό πλαίσιο για την κατάταξη των υπό εξέταση μονάδων (DMUs), με χρήση περιορισμών στους συντελεστές βαρύτητας. Ειδικότερα, προτείνεται η χρήση μιας διαδικασίας πολλαπλών σταδίων για την πλήρη κατάταξη των υπό εξέταση μονάδων, κατά την οποία οι περιορισμοί των συντελεστών βαρύτητας κάθε σταδίου δύνανται να επαναπροσδιορίζονται σύμφωνα με τις κρίσεις των υπεύθυνων λήψης αποφάσεων. Σε κάθε στάδιο της εν λόγω διαδικασίας εκτιμάται η αποδοτικότητα των υπό εξέταση μονάδων με χρήση κατάλληλου υποδείγματος (Super-efficiency DEA model), ενώ οι συντελεστές βαρύτητας προσδιορίζονται μέσω της μεθόδου MACBETH. Η εν λόγω διαδικασία χρησιμοποιείται για την κατάταξη 33 δημόσιων Γενικών Νοσοκομείων και διαπιστώνεται ότι βελτιώνεται η ποιότητα της κατάταξης των υπό εξέταση μονάδων, εν συγκρίσει με την υπάρχουσα διαδικασία κατάταξης ενός σταδίου. Η παρατηρούμενη βελτίωση στην κατάταξη των υπό εξέταση μονάδων θα μπορούσε να είναι καταλυτική σε αποφάσεις που σχετίζονται με την κατανομή κεφαλαίων ή άλλων πόρων. Το δεύτερο μέρος διερευνά τη χρήση ασαφών τριγωνικών αριθμών για τον προσδιορισμό των συντελεστών βαρύτητας, υπό το πρίσμα υφιστάμενων σχέσεων παραγωγής (production trade-off). Η βασική ιδέα της εν λόγω προσέγγισης έγκειται στο γεγονός ότι σε πραγματικές εφαρμογές, οι υπάρχουσες σχέσεις παραγωγής (production trade-offs) μεταξύ εισροών ή/και εκροών μπορεί να είναι εξαιρετικά δύσκολο να εκφραστούν με μη-ασαφείς αριθμούς. Η προτεινόμενη προσέγγιση επιτρέπει στους υπεύθυνους λήψης αποφάσεων να περιορίσουν τους συντελεστές βαρύτητας των μοντέλων DEA, εκφράζοντας περίπλοκες σχέσεις μεταξύ εισροών ή/και εκροών με ασαφείς όρους. Η διατριβή προτείνει μοντέλα DEA για την εκτίμηση της αποδοτικότητας των υπό εξέταση μονάδων, καθώς και στόχων για την επίτευξη πλήρους αποδοτικότητας, τα οποία λαμβάνουν υπόψη την ασάφεια που είναι εγγενής σε πραγματικές συνθήκες.
Το χρώμα στα λογοτεχνικά βιβλία γνώσεων. Αρχέτυπα και συμβολισμοί. Η περίπτωση της μυθιστορηματικής βιογραφίας.
Authors: Αγγελάκη Ρόζη-Τριανταφυλλιά
Published: October 2023

Oι συγγραφείς παιδικών βιβλίων συχνά βασίζονται στη συναισθηματική, κοινωνική, σημειωτική και πολιτισμική λειτουργία των χρωμάτων, προκειμένου να μεταδώσουν πληροφορίες και να διεγείρουν τα συναισθήματα των αναγνωστών τους, να παρουσιάσουν τους χαρακτήρες των βιβλίων τους και να αποκαλύψουν την ιδεολογία τους. Σύμφωνα με μελετητές από πολλά επιστημονικά πεδία,  το χρώμα είναι διάχυτο χαρακτηριστικό της ανθρώπινης ψυχολογικής εμπειρίας, κάτι που η συγγραφέας για παιδιά Μαρία Αγγελίδου φαίνεται να έλαβε υπόψη της όταν συνέγραψε τη σειρά «Το Βυζάντιο σε έξι χρώματα» από τις εκδόσεις Μεταίχμιο (εικ. Κατερίνα Βερούτσου).  Η σειρά αυτή αποτελείται από έξι πραγματογνωστικά βιβλία γνώσεων που συνδυάζουν μυθοπλαστικά στοιχεία με ιστορικές γνώσεις. Χάρη στην περίτεχνη λεκτική αφήγηση που συλλειτουργεί με εκείνη των εικόνων, το αναγνωστικό κοινό ενημερώνεται για το οικουμενικό κράτος του Βυζαντίου, κυρίως μέσα από την περιγραφή της δράσης σημαντικών -αλλά όχι τόσο γνωστών- ιστορικών προσώπων, που ψυχογραφούνται. Τα δε αρχέτυπα και οι συμβολισμοί του Κόκκινου, του Χρυσού, του Άσπρου, του Μαύρου, του Πράσινου και του Γαλάζιου χρώματος, συντελούν στην ανακατασκευή του βυζαντινού παρελθόντος, με το ενδιαφέρον στραμμένο περισσότερο στις μικροϊστορίες ανθρώπων. Εν προκειμένω θα διερευνηθεί ο τρόπος με τον οποίο οι πληροφορίες για κάθε βιογραφούμενο πρόσωπο, το περιεχόμενο και το σκηνικό  των ιστοριών, συνδέονται με την αισθητική, γνωστική, επικοινωνιακή και ψυχολογική διάσταση των χρωμάτων.
Litophellia enoplosa sp. nov., a new species of sea anemone (Actiniaria, Metridioidea) from cold-water coral environments in the North-western Mediterranean Sea
Authors: RODRÍGUEZ ESTEFANIA , COLLINS SOPHIA , GRINYO JORDI , PUIG PERE
Published: October 2023

A new species of sea anemone (Actiniaria, Metridioidea) is described and illustrated from cold-water coral environments at 600 m depth at the Blanes Canyon in the north-western Mediterranean Sea. Litophellia enoplosa sp. nov. is characterized by a column divisible into scapus and scapulus, the former with cuticle forming tenaculi, a mesogleal marginal sphincter muscle, more mesenteries proximally than distally arranged octomerously, and a single pair of directive mesenteries; it has strong retractor and parietobasilar muscles, and acontia with basitrichs and p-mastigophores B2a. Litophellia enoplosa sp. nov. is the second species described in the genus and it can be distinguished from the other species by the cuticle in the column, size ranges of the cnidae, and geographic and bathymetric distribution.
Savings natural resource funds: effectiveness of the Norwegian Government Pension Fund Global
Authors: Dymitrowska Yanina
Published: October 2023

Motivation: Many countries that are rich in natural resources struggle with the resource curse — the phenomenon of achieving worse economic development results by economies specializing in the extraction and export of natural resources. To address this problem, an explicit fiscal tool was proposed — natural resource funds. However, empirical studies on the effectiveness of resource funds conducted so far have delivered mixed and inconclusive results. Specifically, the effectiveness of savings funds, otherwise known as funds for future generations, which are a specific type of natural resource funds, is still being questioned.Aim: This study aims to assess the effectiveness of savings natural resource funds in countries which are rich in natural resources on the example of the Norwegian Government Pension Fund Global (GPFG).Results: The main contribution of this study is to demonstrate the effectiveness of GPFG as a savings fund for future generations. In order to achieve the research objective, a classification of funds was presented and the existing natural resource funds were categorized. Funds were divided into stabilization, investment and savings. The specificity of each type of fund was explained in detail. It was found that all savings funds are also investment funds, but the reverse relationship does not apply. The effectiveness of GPFG was studied considering the functions and tasks of individual fund types. The quantitative study confirmed the effectiveness of GPFG in increasing long-term investments in Norway. At the same time, the fulfillment of the stabilization function by the fund was also validated. The study confirms that the savings fund is an important economic policy measure to counteract the resource curse.
Contemporary concepts of small town development
Authors: Farelnik Eliza
Published: October 2023

Motivation: The paradigms of sustainable development and knowledge and innovation-based economy (smart growth) are among the most important signposts for the development of contemporary towns, cities and regions. The growing competitiveness of cities and the high variation and complexity of the urban environment necessitate the search for such a model of a city that will enable its dynamic development in the economic, social and spatial spheres. The implemented development model determines the town’s ability to face the current challenges, such as population changes, increasing and diverse needs of the city’s users, limited natural resources which therefore require protection, a shift in the paradigm of local economy towards circular economy, thereby improving the town’s ability to deal with crisis (urban resilience). As a consequence, there is a growing number of smart cities as well as cities which have adopted another dominant development concept, such as green cities, slow cities.Aim: Purpose of the article is to discuss and compare some of these concepts, namely smart city, slow city, green city (and selected hybrid models), which can be applied in designing a policy for the development of small towns in Poland.Results: The diverse and increasingly varied conditions underlying the development of small towns mean that a local development policy should have a more reactive and scenario-like character. The process of evolution of the existing approaches can be observed, resulting in the hybridization of the development models, where new concepts arise by combining the assumptions of several approaches, for example a smart green city, etc. This process can be seen as the manifestation of improving the level of urban resilience to crises, which increases the chance of small towns to adapt to new conditions.
The impact of ESG ratings on the market performance of commodity stock sector before and during the COVID-19 pandemic
Authors: Gawęda Adrian , Złoty Marcin
Published: October 2023

Motivation: The growing importance of ESG in the international economy makes the analysed issues extremely interesting. More and more studies show the growing role of ESG performance on company financial and market results as well as analyse the impact of the COVID-19 pandemic on the financial market. The study of rate of return and the relationship between the largest company companies in European Union Member States is of key importance considering the investment portfolio risk.Aim: The main aim of the article is impact assessment of ESG performance of the firm (proxied by ESG scoring by Refinitiv) on the rate of return of commodity sector companies listed on financial markets of European Union Member States. The second goal of the paper is to determine the impact of the COVID-19 pandemic on the rate of return of the analysed companies. The third and final goal is to assess the impact of sector leader status on the rate of return of these companies (i.e. KGHM, PKN Orlen, Royal Dutch Shell and Rio Tinto).Results: ESG disclosure by the surveyed companies and ESG scoring had negative impact on the rate of return, while E, S and G scorings did not affect rate of return at all. Sector leaders were less negatively impacted by the COVID-19 economic crisis than the rest of the sector, however sector leadership status was not statistically significant. COVID-19 pandemic positively influenced the rate of return of analysed companies. In case of commodities stock companies, the economic crisis caused by the pandemic brought about higher levels of uncertainty in the financial markets.
The macroeconomic stability of United Kingdom after Brexit
Authors: Kotliński Kamil
Published: October 2023

Motivation: The United Kingdom has been triggered Article 50 of the Lisbon Treaty on 29th March 2017 and formally has been begun Britain’s exit from EU. The Withdrawal Agreement entered into force on 1 February 2020. The very announcement of Brexit aroused many concerns and uncertainty. The Withdrawal has taken place in an orderly manner, the UK and the EU remain in close partnership with new agreements. Such a significant institutional change also may affect economy and indirectly macroeconomic stability.Aim: This research aims to identify and assess the changes in macroeconomic stability in United Kingdom, from the year before the Brexit referendum to the first year outside the EU, i.e. in 2015–2021.Results: The method used in the study is a comparative analysis that employs a macroeconomic stabilization pentagon model (MSP). The macroeconomic stabilization pentagon is based on the GDP growth rate, the unemployment rate, the inflation rate, the budget balance and the current account balance. Time range of research is 2015–2021. The MSP indicators for United Kingdom and EU-27 are compared. In the period 2015–2018, i.e. during the uncertainty as to the results of the Withdrawal Agreement negotiation, the MSP index fluctuates slightly, which we interpret as very small changes in macroeconomic stability. The UK’s macroeconomic stability has fallen dramatically in 2020, the first year out of the EU. It is worth emphasizing that the UK’s macroeconomic stability was lower than EU-27one throughout the period studied.
The socioeconomic development of rural municipalities representing various demographic and functional types
Authors: Kudełko Joanna
Published: October 2023

Motivation: Rural areas are usually characterised by a slower pace of growth as compared with urban areas. However, they do not constitute a uniform group of entities, representing a considerable diversity in terms of development. Among the determinants of the socio-economic development of rural areas, an important role is played by their demographic potential and the economic functions performed. The demographic typology of municipalities is used in identifying population development types in the analysed entities, depending on natural growth rates and a migration balance. The functional typology of rural municipalities is based on differences between them in terms of socio-economic structure. Understanding the relationship between the development of a municipality and its demographic and functional type is indispensable for planning the development policy and for formulating local strategies.Aim: The aim of the paper is to assess gaps in the level of development of the rural municipalities of Małopolska Voivodeship, depending on the demographic types they represent and the economic functions they perform.Results: The results of the conducted analyses indicate that the highest levels of development among Małopolska’s rural municipalities are recorded by urbanised areas. These levels are much higher than in the remaining entities classified as multi-income, agricultural and tourist municipalities. It was proved that the best developed municipalities record an increase in the number of population resulting from a positive migration rate. There is a correlation between a demographic and functional type of municipalities.
VEGF and its receptors - formation, structure, and role in the organism
Authors: Olczyk Krzysztof , Partyka Robert , Misiło Adriana , Zając Kacper
Published: October 2023

Creating vessels is essential for the development of every organism and the course of repair processes. Under physiological conditions, angiogenesis is a transient and tightly regulated process. Angiogenesis plays a significant role in the development of cancer and the progression of neoplastic diseases. The most well-known pro-angiogenic factors include the VEGF family, mainly VEGF-A. Of great interest in the angiogenesis process are the receptors for VEGF, both soluble and surface-bound.

The aim of this work is to  elucidate the structure and mechanism of action of VEGF and its receptors.
Bez znieczulenia – transformatywne uczenie się seniora oddziału terapeutycznego
Authors: Żeromska-Charlińska Joanna
Published: October 2023

Inspiracją do podjęcia próby przedstawienia przejawów kryzysu kondycji starszego człowieka w okolicznościach mobilizujących do zmian była potrzeba zaakcentowania możliwości podejmowania ryzyka indywidualnego, zwiększającego kontrolę nad własnym życiem. Celem badań uczyniłam (re)konstrukcję konstytuującego etapy zdrowienia procesu trajektorii transformatywnego uczenia się pacjenta w wieku senioralnym w przestrzeni oddziału terapeutycznego. To próba rozumienia inkluzyjnego wysiłku podmiotu w drodze do zdrowienia z perspektywy terapeuty pracującego na Oddziale Terapii Uzależnień Alkoholowych (OTUA). Koncentracja uwagi badacza na założeniach paradygmatu interpretatywnego zadecydowała o wyborze koncepcji podmiotu kinestetycznego oraz próbie przeformułowania jego statusu w teorii uczenia się transformatywnego Jacka Mezirowa. Część empiryczna zmierzała do znalezienia odpowiedzi na pytanie: W jaki sposób oddziaływania w warunkach OTUA wobec podopiecznego z zaburzeniami używania alkoholu umożliwiają transformatywne uczenie się? Materiał empiryczny pochodzi z wywiadu pogłębionego ze specjalistą psychoterapii uzależnień, obejmującego odniesienia subiektywne pacjenta, efektywność celowych i niezamierzonych oddziaływań terapeutycznych w sytuacji doświadczenia uczenia się zmian zachowania pacjenta. Wyniki eksploracji wskazują, że zmiana ramy odniesienia pacjenta może wynikać z adaptacyjnego zobowiązania do przestrzegania reguł obowiązujących w procesie terapii, wymuszających na nim radykalne przekształcenia dotychczasowych schematów postępowania.
La terminología de la semántica
Authors: Casas Gómez Miguel , Varo Varo Carmen
Published: October 2023

Este volumen presenta un panorama actualizado de las investigaciones sobre terminología llevadas a cabo por el grupo de investigación Semaínein, centrado en los últimos años en la indagación de los usos terminológicos relacionados con la semántica y sus diferentes interfaces con otras disciplinas. De esta manera, las contribuciones que conforman la obra constituyen un compendio de avances y propuestas dirigido no solo a la mejora de la denominada práctica terminográfica general, al proporcionarse herramientas metodológicas y recursos para acometer su sistematización, sino también a integrar los conocimientos sobre esta disciplina, atendiendo tanto a sus múltiples conexiones con otros ámbitos científicos como a su registro e interpretación en las fuentes doctrinales y documentales. Para ello, se emplea un amplio corpus referencial de carácter metalingüístico y multilingüe, así como un exhaustivo cotejo de numerosos diccionarios de lingüística.
NOVEDADES EN TORNO A LA VIDA Y OBRA DE LOS ESCULTORES ALONSO (1625-1680/1681) Y JOSÉ DE ROZAS (1662-1725)
Authors: Baladrón Alonso Javier
Published: October 2023

Alonso Fernández de Rozas y su hijo José de Rozas constituyen uno de los linajes más relevantes de la escultura barroca vallisoletana. A pesar de tratarse de dos de los maestros más conocidos sin embargo sus biografías aún presentan algunas lagunas en lo referente a datos concretos de sus acontecimientos vitales claves. En las próximas páginas se aportará una serie de novedades biográficas y se darán a conocer obras documentadas, inéditas e incluso algunas atribuciones, de forma que se aumentarán sensiblemente sus catálogos productivos.
APUNTES PARA EL ESTUDIO DE LAS SILLERÍAS DE CORO DEL CLERO SECULAR DE JEREZ DE LA FRONTERA
Authors: Pomar Rodil Pablo
Published: October 2023

La colegiata y el resto de parroquias de Jerez de la Frontera contaban con sus respectivos coros para la asistencia del clero a la misa y el oficio. De estos recintos, compuestos de rejas, cerramientos, órganos, facistoles, y pequeños altares, las sillerías de escaños suponían su origen y explicaban su existencia. Lamentablemente desaparecidas o desmembradas, en el presente estudio se compilan las noticias conocidas, pero hasta ahora dispersas, con nuevos datos inéditos y el estudio de los restos materiales conservados. Se conforma de este modo una primera aproximación de conjunto a estas piezas singulares del mobiliario eclesiástico jerezano.
RANGO Y OSTENTACIÓN EN LA NOBLEZA ANDALUZA DEL SIGLO XVIII: LAS CAPITULACIONES MATRIMONIALES DE LOS MARQUESES DE QUINTANA DE LAS TORRES (1764)
Authors: Rosillo Fairén Bárbara
Published: October 2023

El objetivo del presente artículo es la descripción y análisis de la indumentaria femenina y de los usos suntuarios del estamento noble en España a mediados del siglo XVIII, partiendo de las capitulaciones del matrimonio formado por don Fernando Arias de Saavedra, marqués de Quintana de las Torres, y de doña Isabel de Hoces Venegas, miembros respectivamente de las aristocracias de Écija y Córdoba, escrituradas en 1764. Las cartas y recibos de dote suponen una fuente esencial para el estudio del ajuar doméstico en general y fundamentalmente de la moda, ya que nos permiten conocer con gran detalle, no solamente las distintas prendas que usaban las mujeres de toda la escala social, sino también los tejidos, colorido, ornamentaciones y precios.
UNA DIVINA PASTORA INÉDITA ATRIBUIBLE AL PINTOR ALEMÁN FRANZ XAVIER RIEDMAYER Y NUEVAS ADICIONES A SU CATÁLOGO
Authors: Román Villalón Álvaro
Published: October 2023

El presente estudio da a conocer una pintura de la Divina Pastora, contrastándola con su fuente grabada, de Francisco Muntaner, bajo diseño de Jerónimo Boix de Berard, y sugiriendo, por su estilo academicista y su comparación con la obra de Franz Xavier Riedmayer, su atribución a este pintor alemán afincado en Cádiz entre finales del siglo XVIII y principios del XIX, aportando, además, nuevas adiciones a su catálogo.
EL RETABLO SEVILLANO EN LA PRIMERA MITAD DEL SIGLO XIX. NUEVAS APORTACIONES
Authors: Amores Martínez Francisco
Published: October 2023

En el presente trabajo abordamos la personalidad y la producción de varios maestros tallistas activos en Sevilla durante la primera mitad del siglo XIX, aportando nuevos datos biográficos y profesionales sobre Francisco de Acosta el Mozo, José Gabriel González, Francisco del Valle y José Jiménez, así como del pintor y dorador José Roso.
MARIANO BENLLIURE GIL, EL EXPONENTE DE LA MODERNIDAD EN LA IMAGINERÍA PROCESIONAL MALAGUEÑA TRAS LA DESTRUCCIÓN DE MAYO DE 1931
Authors: Zambudio Moreno Antonio
Published: October 2023

La caída del régimen monárquico y el advenimiento de la II República en 1931 no conllevó la paz social tan deseada en España, acrecentándose el enfrentamiento entre dos facciones diametralmente opuestas en su ideario: el nacionalcatolicismo y el anticlericalismo. Los terribles sucesos del mes de mayo de ese año provocaron la destrucción patrimonial más brutal hasta esa fecha, siendo Málaga una de las ciudades más afectadas. Las cofradías de Semana Santa se vieron en la necesidad de reponer todo sus enseres perdidos y ahí entra en juego la figura del escultor Mariano Benlliure Gil, que con sus obras del Nazareno del Paso y el Cristo de la Expiración configura un novedoso lenguaje en la imaginería religiosa del sur peninsular.
OTRA NUEVA INMACULADA CONCEPCIÓN DE IGNACIO DE RIES
Authors: Fernández López José
Published: October 2023

En este artículo se estudia una nueva obra de Ignacio de Ríes, localizada en la parroquia de Nuestra Señora de Belén, en la localidad de Gines, Sevilla. Ignacio de Ríes, pintor de la escuela sevillana de la primera mitad del siglo XVII, fue un artista muy interesante cuya personalidad creativa es cada vez mejor conocida, pasando actualmente de ser sólo un colaborador del taller zurbaranesco a un pintor con entidad propia y sobresaliente en la escuela local.
DIBUJOS DE LIMA VIRREINAL: DOS FRONTISPICIOS DE FRAY GREGORIO MONEL
Authors: Holguin Valdez Anthony
Published: October 2023

Este artículo expone el contexto histórico de la práctica del dibujo en Lima en el periodo virreinal. Gracias a la documentación localizada en el Archivo de la Provincia Dominicana de San Juan Bautista del Perú, ha sido posible encontrar testimonios gráficos inéditos, como son los dos dibujos de frontispicios del fraile Gregorio Monel. El hallazgo de estas obras firmados y fechados por su autor nos permite conocer la práctica artística de principios del siglo XVIII.
UN SAN JOSÉ Y UN ECCE HOMO ATRIBUIBLES AL ESCULTOR MALAGUEÑO FERNANDO ORTIZ
Authors: Flores Matute Francisco Jesús
Published: October 2023

Presentamos dos esculturas inéditas que, por sus características formales, técnicas y estéticas pueden ser asignadas al catálogo del escultor malagueño del siglo XVIII Fernando Ortiz Comarcada, encontrándose una de ellas en Bornos (Cádiz) y la otra en Benamejí (Córdoba).
DOS OBRAS INÉDITAS DE BLAS MOLNER EN CARMONA (SEVILLA)
Authors: Porres Benavides Jesus , Prado Romera Fernando
Published: October 2023

Se analizan dos esculturas del escultor valenciano Blas Molner pertenecientes a la iglesia de San Blas de Carmona, sede de la Hermandad de la Expiración: la imagen de la Virgen del Rosario, atribuible a su quehacer, y el San Blas, titular de la iglesia, documentado. En esta última se ha confirmado la firma en el libro que lleva el santo, así como el pago de la imagen en los libros de fábrica de la iglesia.
ARTE Y FIESTA EN LA SEVILLA CONTEMPORÁNEA: LA CABALGATA ALEGÓRICA DE 1900
Authors: Pérez Calero Gerardo
Published: October 2023

En este trabajo se aborda el estudio artístico de la Cabalgata alegórica en el marco de la Sevilla industrial y lúdica de 1900
El canto como una práctica de cohesión humana, rapsodias de recuperación en clave pos-covid
Authors: Garzón Díaz Karim del Rocio , Moncayo Barbosa Patricia , Lucena Ramírez Julio César , Palacios Espinosa Ximena , Vera Márquez Ángela Victoria , Villamil Duarte Angy Carolina
Published: October 2023

Este artículo presenta a manera de balance una intención pedagógica e interprofesional que fue materializada a través de un proyecto que buscó co-construir un programa basado en el canto, orientado a la formación de agentes de cambio para favorecer encuentros con personas sobrevivientes a estados críticos producidos por el virus sars-CoV-2 (covid-19) en proceso de recuperación en sus hogares, como una estrategia de promoción de la salud cardiopulmonar y emocional. La impronta del proyecto estuvo mediada por el interés de confluencia entre las ciencias y las artes, así como de hacer parte a estudiantes rosaristas.
Accounting for Negative Attention: Status and Costs in the Market for Audit Services
Authors: Ody-Brasier Amandine , Sharkey Amanda J.
Published: October 2023

Prior work has emphasized the role of positive attention spillovers in driving cost advantages for high-status firms, with exchange partners offering preferential terms to high-status organizations because they anticipate benefits. Yet, spillovers from a client to a supplier may also be negative. These negative spillovers can be exacerbated when high-status actors are involved, because of the high level of publicity they attract. In this paper, we propose that suppliers’ concerns about negative attention are an important contingent factor determining whether high-status firms enjoy cost advantages or, instead, pay a premium. We expect that when suppliers anticipate that negative spillovers are more likely than positive ones and when they enjoy some bargaining power over their clients, a positive relationship between status and costs will result. To test this argument, we analyze fees paid by clients of varying status levels in the U.S. market for audit services. Consistent with our theory, we find that (1) high-status clients are charged more than their lower status peers and (2) the media attention clients receive does mediate this relationship. Indicative of the role of the supplier’s expectation of negative spillovers and their bargaining power, we also demonstrate that the positive relationship becomes stronger when auditors view clients as presenting a greater risk of future negative events and when clients have more bargaining power. Our efforts at theoretical integration result in a fuller picture of the role of status in shaping a firm’s costs, suggesting that status involves advantages in some settings but disadvantages in others.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2021.15814 .
Doenças no pós-abolição: o impacto das doenças em pretos e pardos na região metropolitana do Rio de Janeiro (1888-1940)
Authors: Costa Carlos Eduardo Coutinho da
Published: October 2023

O presente artigo busca apresentar os primeiros resultados de uma pesquisa direcionada ao impacto das doenças na população negra no período Pós-abolição. Escolhi como área de estudo a região metropolitana do Estado do Rio de Janeiro com a finalidade de compreender como a população dessas regiões foi impactada pelos surtos de doenças respiratórias e infectocontagiosas nos primeiros anos da República. Para atingir tais objetivos, criticando o uso dos discursos médicos, jornais imprecisos e estudos concentrados em capitais, analisarei os registros civis de óbitos do antigo município de Iguaçu que apresentam dados relativos à cor, à idade, ao ano de morte e, principalmente, às causas mortis. Estes, por sua vez, serão comparados com os censos até o ano de 1940. Ao final, pretende-se produzir uma contribuição significativa para a historiografia o impacto significativo que famílias de pretos e pardos sofreram na região metropolitana do Estado do Rio de Janeiro.
Para lembrar José Murilo de Carvalho (1939-2023)
Authors: Pereira das Neves Guilherme , Maria Bastos Pereira das Neves Lúcia
Published: October 2023

Texto em homenagem ao professor e historiador José Murilo de Carvalho (1939-2023), falecido no dia 13 de agosto de 2023.