bluuebunny/crossref_metadata_2025 huggingface dataset:
ETPSR: Employee Turnover Prediction with Security Recommendations
Authors: Chandgadkar Vaishnavi , Pathak Prachi , Solanki Aditya , Shrivastava Aryansh , Maktum Tabassum , Pulgam Namita
Published: April 2024

In today’s dynamic business environment, employee turnover poses a significantchallenge for organizations due to the competitive job market. Departing employ-ees may pose cybersecurity risks by retaining access to sensitive data and criticalsystems. This necessitates a focus on data security during the offboarding process.Traditional approaches lack proactive measures, relying on manual interventionsand potentially leaving gaps in data protection. To address this, the research pro-poses integrating a Cloud Services Security Recommendation (CSSR) model intothe prediction model. Leveraging machine learning and cybersecurity principles,the CSSR model identifies likely switchers and provides personalized security rec-ommendations. The research comprises of four components: a predictive model foridentifying potential switchers, an Explainable AI approach for behavior profilingand risk assessment, and integration with existing cybersecurity infrastructure toprovide tailored security recommendations. The CSSR model offers a proactivesolution to employee turnover and data security issues, enabling organizations tofortify their cybersecurity posture and protect sensitive information. The system employed in this study, the Employee Transition Prediction and Security Recom-mendations (ETPSR), integrates advanced analytics and cybersecurity principlesto offer tailored security measures during employee offboarding, ensuring dataintegrity and confidentiality throughout the transition process.
Implementation of a Full-Duplex Visible Light Communication System
Authors: Fotso S. B. Nono , Mbe Jimmi Hervé Talla , Ndjiongue Alain Richard , Nzeukou Armand C.
Published: April 2024

In telecommunication research, most outputs are based on simulation and/or analysis. Practical implementations are scarce. This is the case with visible light communication systems. With the knowledge that there is a gap between theoretical and practical implementation, we propose in this paper a two-way light communication system that provides efficient transmitting and receiving of files between two nodes. First, we develop hardware consisting of an emitting antenna, a receiving antenna, and a microcontroller. In order to ensure file transmission, we also develop software using the MATLAB programming language. Experimental results indicate that the bit error rate (BER) of the system increases with the transmission range, the data rate, and the angle of incidence. Accordingly, the recovered files match the transmitted files without any error correction scheme. An appropriate choice of system parameters can allow the BER to reach zero. An effective data rate of 1 Mbps is obtained with a BER of $6\times10^{-6}$. In addition, when data communication is not taking place, the designed modems provide illumination to the environment to meet the other requirements of visible light communication. Finally, the designed light-communication system proves cost-effective and easy to implement.
Joint Optimization of User Association and Resource Allocation in HetNets: A parameterized-DRL Approach
Authors: Fu Pingbo , Li Hui , Tao Xu , Wang Ziwei
Published: April 2024

Facing the problem of resources utilization in of multiple wireless communication systems with multiple coverage, convergence of heterogeneous network (HetNets) can reduce the burden and decrease deployment costs of a single communication network. Due to the non-convexity of joint optimization and the difficulty to obtain the feasible solution of the mixed operation space (i.e. discrete operation versus continuous operation) of HetNets, so it is a formidable challenge to achieve global optimization of energy efficiency (EE) and spectral efficiency (SE) simultaneously when facing user association (discrete) together with power allocation (continuous). Unlike the method of deep reinforcement learning (DRL) by discretizing continuous space directly, we proposed a novel parameterized-DRL that maximizes the performance of joint EE-SE while ensuring the quality of service (QoS) of downlink user devices (UEs) in HetNets. In addition, to solve the computationally intensive problem in the state-action space, an algorithm of parameterized-experience-replay dueling double DQN with multi-agent priority (P-MAPD3QN) is introduced to obtain an almost optimal QoS. Simulation results show that this algorithm improves the effectiveness of the system by 4.9% over traditional D3QN algorithm in terms of system capacity and 13.1% in terms of joint EE-SE performance.
Flapping Wing Energy Harvesting, Experiences with Modified Time Variations at high Re-Number
Authors: Geißler Wolfgang
Published: April 2024

Wind energy converters with rotating blades are most common for energy harvesting. In special cases a system of flapping wings may be of interest where the wings are oscillating in combined flapping (plunging) and pitching modes respectively. Then the ratio of plunging and pitching amplitudes is of main concern: for animal flight the thrust production and its optimization as well as the sufficient lift force are important, for energy harvesting the maximum energy extraction from the oncoming flow and a minimized energy input into the system are of main importance.
If one looks into the details of energy flows it is obvious that for animal flight the energy input via muscles is dominating whereas for energy harvesting main energy flow is transferred from the fluid into the oscillating system i.e., the direction of energy flow is reversed in both cases.
With these fundamental aspects in mind, it is of interest to increase and optimize the energy input from the fluid. One important measure may be the modification of the time variation: usually the time varies harmonically within one period of oscillation. In the present paper modified time variations are investigated in detail. Phase variation between modes as well as dynamic deformation of the airfoil are of further concern and will be discussed in the present paper.
The serine protease Brachyuran is highly expressed in the posterior midgut of the black soldier fly, Hermetia illucens, during the processing of horse droppings
Authors: Wakuda Megumi , Sakamoto Takuma , Tanaka Akane , Sugimura Satoshi , Higashiura Yuki , Nakazato Takeru , Bono Hidemasa , Tabunoki Hiroko
Published: April 2024

Objective
Livestock droppings cause some environmental problems, but they have the potential to be used as effective biomass resources. The black soldier fly (BSF), Hermetia illucens (Diptera: Stratiomyidae), is suitable for the efficient processing of livestock droppings. By using BSF larvae for the disposal of livestock droppings, we can obtain two valuable products: protein resources and organic fertilizer. However, there is not enough research on the digestive enzymes suitable for processing livestock droppings. Here, we aimed to construct an efficient BSF processing system using livestock droppings, and we explored the digestive enzymes involved in this process.
Results
First, we investigated the characteristics of transcripts expressed in the midgut of H. illucens and found that immune response-related genes were expressed in the midgut. Then, we investigated digestive enzymes and identified a novel serine protease, HiBrachyuran, whose mRNA was highly expressed in the posterior midgut when H. illucens larvae fed on horse droppings. Despite the low protein content of horse droppings, larvae that fed on horse droppings accumulated more protein than did those in the other groups. Therefore, HiBrachyuran may contribute to digestibility in the early stage of protein degradation in H. illucens larvae fed on horse droppings.
FDEM simulation study on the development of water-conducting fractures in fault-bearing roof under repeated mining of extra-thick coal seams
Authors: Longquan Mai , Hao Li , Zhiqin Kang
Published: April 2024

The formation of water-conducting fractures in overlying strata caused by underground coal mining not only leads to roof water inrush disasters, but also destroys the sustainability of underground aquifers. This phenomenon is particularly significant in extra-thick coal seams and fault-bearing areas. Numerical simulation is an effective method to predict the failure range of mining overburden rock with low cost and high efficiency. The key to its accuracy lies in reasonable constitutive model and simulation program. In this study, considering that the three parts of penetrating cracks, non-penetrating cracks and intact rock blocks are often formed after rock failure, the contact state criterion and shear friction relationship of discrete rock blocks and the mixed fracture displacement-damage-load relationship are established respectively. Combined with Mohr-Coulomb criterion, the constitutive model of mining rock mass deformation-discrete block motion and interaction is formed. On this basis, according to the engineering geological conditions of Yushupo Coal Mine, a numerical model for the development of water-conducting cracks in the roof with faults under repeated mining of extra-thick coal seams is established. The results show that: The constitutive relation of continuous deformation-discrete block interaction of overlying strata and the corresponding finite element-discrete element FDEM numerical program and VUSDFLD multi-coal seam continuous mining subroutine can numerically realize the formation process of faults and water flowing fractures in overlying strata under continuous mining of extra-thick multi-coal seams. The toughness of sand mudstone is low, and the fracture will be further developed under the repeated disturbance of multi-thick coal seam mining. Finally, it is stabilized at 216m-226m, and the ratio of fracture height to mining thickness is 14.1. When the working face advances to the fault, the stress concentration occurs in the fault and its overlying rock, which leads to the local fracture of the roof rock mass and the formation of cracks. The fault group makes this phenomenon more obvious. The results have been preliminarily applied and tested in Ningwu mining area, which provides theoretical support for further development of roof water disaster control under the condition of extra-thick coal seam.
Machine Learning Prediction of Intestinal α-Glucosidase Inhibitors Using a Diverse Set of Ligands: A Drug Repurposing Effort with DrugBank Database Screening
Authors: Odugbemi Adeshina I. , Nyirenda Clement , Christoffels Alan , Egieyeh Samuel A.
Published: April 2024

The global rise in diabetes mellitus (DM) poses a significant health challenge, necessitating effective therapeutic interventions. α-Glucosidase inhibitors play a crucial role in managing postprandial hyperglycemia and reducing the risk of complications in Type 2 DM. Quantitative Structure-Activity Relationship (QSAR) modeling is critical in computational drug discovery. However, many QSAR studies on α-glucosidase inhibitors often rely on limited compound series and statistical methods, restricting their applicability across wide chemical space. Integrating machine learning (ML) into QSAR offers a promising avenue for discovering novel therapeutic compounds by handling complex information from diverse compound sets. Our study aimed to develop robust predictive models for α-glucosidase inhibitors using a dataset of 1082 compounds with known activity against intestinal α-glucosidase (maltase-glucoamylase). After thorough data preparation, we employed 626 compounds to train ML models, generating different training data of three distinct molecular representations: 2D-descriptors, 3D-descriptors, and Extended-connectivity-fingerprint (ECFP4). These models, trained on random forest and support vector machine algorithms, underwent rigorous evaluation using established metrics. Subsequently, the best-performing model was utilized to screen the Drugbank database, identifying potential α-glucosidase inhibitor drugs. Drug repurposing, an expedited strategy for identifying new therapeutic uses for existing drugs, holds immense potential in this regard. Molecular docking and dynamics simulations further corroborated our predictions. Our results indicate that 2D descriptors and ECFP4 molecular representations outperform 3D descriptors. Furthermore, drug candidates identified from DrugBank screening exhibited promising binding interactions with α-glucosidase, corroborating our ML predictions and supporting their potential for drug repurposing.
Correlation of Mental Health and Physical Activity, A cross-sectional study among a sample in Damascus, Syria
Authors: Al-Nakri Hussam , Ibrahim Naya
Published: April 2024

Introduction
Mental health disorders are one of the leading causes of global health burden, and are clearly a high-cost problem on both an individual and societal scale. Hundreds of research trials have been conducted measuring the effect of physical activity on depression, anxiety, and stress, many of which suggest that exercise may have effects similar to psychotherapy and pharmacotherapy.
Materials and Methods
A cross-sectional study was conducted among a sample of residents of Damascus, Syria. The inclusion criteria included all those who responded to the questionnaire within the time period between September and December 2023, being 18 years and older. Using the questionnaire, data was collected for 500 participants. The questionnaire consists of five sections (Demographic information and social customs; Ricci-Gagnon scale for evaluating physical activity; Questions related to sleep quality and its disorders; Patient Health Questionnaire - Depressive Disorder PHQ9; Patient Health Questionnaire - Generalized Anxiety Disorder PHQ-GAD7). The data were analyzed using the Statistical Package for the Social Sciences (SPSS) version 26.0, using the Chi-Square test of independence, and the T test was also used.
Statistical test results
A study on a sample size of 500 people was conducted. 47% of the sample were male and 53% female, only 7.8% of whom suffered from chronic diseases. The largest percentage of participants in the sample recorded that their parents had a university degree, as 69.4% of the sample had a father who had a university degree, while 56% of them had a mother who had a university degree.
There is an important and significant correlation between the gender of the participant and its commitment to sports, and the general psychological state, depressive symptoms, symptoms of generalized anxiety disorder.
There is an important and significant effect of sedentary behavior and lack of physical activity on the psychological state of participants, and depressive symptoms and their frequency, symptoms and frequency of anxiety disorders, its sleep quality.
There is an important and significant effect of regular exercise on the general psychological state of participants, depressive symptoms and their frequency in participants, their quality of sleep, symptoms of generalized anxiety disorder.
THE RELATIONSHIP BETWEEN ORTHODONTIC TREATMENT AND SPEECH THERAPY CORRECTION IN THE REHABILITATION OF CHILDREN WITH CLEFT LIP AND PALATE
Authors: Filonenko Valerii , Kaniura Oleksandr , Yakovenko Anna
Published: April 2024

The aim of the study: substantiation, approval and clinical practice implementation of a complex system to influence overcoming speech disorders in children with cleft lip and palate (CLP) with simultaneous conduct orthodontic treatment.
Materials and methods. An examination of 97 children aged 4.5 to 14 years with unilateral CLP at the stages of multidisciplinary complex rehabilitation was performed. In all the subjects, dentognathic deformations violations of kinetic and kinesthetic praxis’s, speech defects and speech breathing, presence of nasalization were found. 48.5% of patients (n=47) underwent orthodontic treatment and corrective training with a speech therapist for 6–9 months.
Results. Corrective work consisted of two stages: preparatory and main. Based on the calculation per child before the start of treatment, an average of 11 sound-speech errors were found among all the subjects. As a result of the work carried out to overcome speech disorders, the variability of errors in sound pronunciation among patients who were simultaneously undergoing orthodontic treatment with removable orthodontic appliances (n=31) and underwent corrective speech therapy training decreased by 4.1 times, with fixed appliances (n=16) – by 2.5 times.
Conclusions. Speech disorders in children with CLP are most effectively corrected with early competent interdisciplinary interaction of a speech therapist and an orthodontist using innovative and original technologies, and the variability of speech devices with the use of an individual differentiated approach, which significantly improves the formation of the phonetic side of speech.
LOW HIGH-DENSITY LIPOPROTEIN LEVEL ASSOCIATED WITH ENHANCED INFLAMMATORY RESPONSE AND ONE-YEAR PERSISTENCE OF LONG COVID IN PATIENTS UNDERGOING HEMODIALYSIS: A CROSS-SECTIONAL COHORT STUDY
Authors: Stepanova Natalia , Driianska Victoria , Rysyev Andriy , Snisar Lyudmila , Kolesnyk Mykola
Published: April 2024

Background: Long-term consequences of COVID-19, known as long COVID, present distinctive hurdles for patients receiving hemodialysis treatment. Reduced levels of high-density lipoprotein (HDL) (< 1.22 mmol/L) have previously been demonstrated to be associated with heightened susceptibility to COVID-19 and immediate COVID-19-related adverse outcomes in this patient population. However, the potential association between HDL levels and the persistence of long COVID has not been examined within the hemodialysis cohort. The present study aimed to explore the relationship between HDL levels and inflammatory responses one year after COVID-19 among patients undergoing hemodialysis.
Methods: A total of 80 patients treated with hemodialysis, aged 55 (44-62.5) years, with a dialysis vintage of 45 (21-78.6) months and a history of COVID-19, were enrolled in this cross-sectional cohort study. Among them, 45 (56.2%) were diagnosed with long COVID, while 35 (43.8%) had fully recovered. Lipid profiles and inflammatory markers, such as serum C-reactive protein, and interleukins -6 and -17, were assessed one year post-infection.
Results: Patients experiencing long COVID exhibited significantly lower HDL levels compared to fully recovered individuals: 1.19 (1.06-1.76) vs 1.66 (1.32-1.92) mmol/L (p < 0.0001). The HDL cut-off point of less than 1.22 mmol/L demonstrated a sensitivity of 84.9% and specificity of 95.3% to predict one-year long COVID persistence in our cohort. Among the patients with HDL levels < 1.22 mmol/L, elevated concentrations of C-reactive protein (р = 0.003), interleukin-6 (p = 0.005), and interleukin-17 (p < 0.0001) were evident compared to those with HDL concentrations exceeding 1.22 mmol/L. Subsequent subgroup analysis revealed a more pronounced inflammatory profile in patients concurrently experiencing long COVID and exhibiting low HDL levels.
Conclusion: The obtained results suggest that a low level of HDL (< 1.22 mmol/L) may exacerbate the inflammatory response in patients undergoing hemodialysis, potentially contributing to the persistence of long COVID even a year after infection. Future research is necessary to elucidate the pathogenetic mechanisms of this relationship and explore potential strategies to improve patient outcomes.
ASSESSING MUCOSAL IMMUNITY IN PATIENTS WITH ORAL DISEASES ASSOCIATED WITH RHEUMATOID ARTHRITIS
Authors: Povsheniuk Anastasiia , Gadzhula Nataliia , Rekun Tetiana
Published: April 2024

Introduction. The association between diseases of connective tissue and oral cavity are of increased interest for scientists because they can contribute to the burden of the pathological process of each other and the occurrence of recurrences. Given that autoimmune disorders in rheumatoid arthritis are the main ones, it is advisable to study the specific and non-specific immunity features of the oral cavity in associated diseases.
Methods. The research group included 19 patients with benign migratory glossitis and 16 patients with atrophic glossitis. 15 practically healthy persons made up the control group. The levels of IgA, IgG and lysozyme were determined by radial immunodiffusion according to Mancini method and with the use of biomass powder of Micrococcus lysodeicticus, respectively. Statistical analysis of the obtained results was performed using Statistica 6.1.
Results. The high levels of IgG in the oral fluid was found in both research groups (p<0.001). In patients with benign migratory glossitis, high levels of secretory IgA (p>0.05) and serum IgA (p<0.001) were found, while in patients with atrophic glossitis associated with rheumatoid arthritis, there was a significant decrease in the content of sIgA and lysozyme, and similar increase in mIgA content.
Conclusions. Oral mucosal diseases associated with RA are accompanied by suppression of defense mechanisms of the oral cavity and its local immunity, which is characterized by a decrease in the levels of lysozyme and secretory IgA in the oral fluid of patients.
Selection of pollinators for promising large­fruited varieties of sweet cherry Cerasus avium (L.) Moenh in Forest­Steppe conditions
Authors: Kishchak O. A. , Slobodianiuk A. V.
Published: April 2024

Purpose. Selection of effective pollinators for promising large­fruited sweet cherry varieties in the Forest­Steppe of Ukraine. Methods. Field, laboratory and analytical methods were used in the research. Pollen viability and self­fertility were determined in 29 varieties of different ripening periods. Pollinators were selected for the group of medium­late and late varieties (‘Krupnoplidna’, ‘Talisman’, ‘Stark Hardy Giant’, ‘Anons’, ‘Temporion’, ‘Zodiak’, ‘Annushka’, ‘Anshlah’ and ‘Regina’). The surveys were carried out in accordance with the approved scientific and methodological recommendations. Results. In the group of early varieties, the highest pollen quality (77.9%) was produced by ‘Valerii Chkalov’; among the varieties of medium ripening period – ‘Talisman’ (control) (87.3%), ‘Yaroslavna’ (78.8%) and ‘Melitopolska Myrna’ (86.7%); medium late and late – ‘Drogan’s grosse gelbe’, ‘Kordia’, ‘Regina’, ‘Zodiac’ and ‘Annushka’ (80.9–88.0%). A full crop of all the varieties studied can only be guaranteed under the condition of cross­pollination. The highest level of fruit set (47.9–56.1%) in ‘Talisman’, ‘Temporion’, ‘Stark Hardy Giant’ and ‘Anshlah’ was due to pollen of ‘Krupnoplidna’. Conclusions. The versatility of ‘Donchanka’ as a pollinator was revealed. When it was used, fruit set in relation to free pollination was 111.2–148.8%. ‘Krupnoplidna’ and ‘Stark Hardy Giant’ proved to be mutual pollinators and effective pollinators for the vast majority of varieties. The variety ‘Regina’ was best pollinated by ‘Donchanka’ and ‘Drogan’s grosse gelbe’ with fruit set of 24–26.6% and 134.8–149.4% respectively compared to the control.
REGARDING THE GRANTING OF THE RIGHT TO ACCESS MATERIALS OF A CRIMINAL INVESTIGATION BY AN INDIVIDUAL, THE RIGHTS OR LEGITIMATE INTERESTS OF WHICH ARE RESTRICTED DURING THE PRE-TRIAL INVESTIGATION
Authors: Hnatiuk Andrii Yu.
Published: April 2024

This article focuses on exploring the category defined in paragraph 161 of Article 3 of the Criminal Procedure Code of Ukraine, known as the "other person," whose rights and lawful interests are restricted during the pre-trial investigation. The authors note that currently, the rights and responsibilities of this participant are not explicitly regulated by procedural legislation, which negatively

affects the protection of the rights of individuals who are not suspects but are subjected to procedural actions during the pre-trial investigation. Moreover, this lack of regulation can complicate the differentiation of this participant from others in terms of safeguarding their rights and freedoms. The article examines cases where procedural actions are taken against such individuals, restricting their rights without notifying them of suspicion. However, from the perspective of the Unified Register of Pre-trial Investigations, these individuals may be considered potential suspects. The insufficient regulation of the rights of other persons in this context can complicate the assessment of the completion of pre-trial investigation periods. The article addresses the need for a clear delineation of the rights and responsibilities of these individuals, whose rights and lawful interests are restricted during the pre-trial investigation, and emphasizes the importance of legislative regulation to ensure compliance with the principles of a fair criminal process. The author also underscores that the right to defense arises not only after a person becomes a suspect but from the moment procedural actions are carried out concerning that individual. However, inadequate regulation of the rights and responsibilities of these individuals during the pre-trial investigation can hinder their ability to receive proper protection. The author suggests amending the legislation, specifically Article 221 of the Criminal Procedure Code of Ukraine, to include the new participant in the list of individuals who have the right to familiarize themselves with the materials of the investigation before its completion. This would contribute to safeguarding the rights and interests of these individuals and upholding the principles of a fair criminal process in Ukraine.
ON THE ISSUE OF REPEAL OF AN ACT ESTABLISHING ADMINISTRATIVE LIABILITY AS A CIRCUMSTANCES EXCLUDING PROCEEDINGS IN THE CASE OF AN ADMINISTRATIVE OFFENSE
Authors: Kushch Oleksii Ye.
Published: April 2024

The article is devoted to problematic issues of the application of one of the circumstances that exclude proceedings in cases of administrative offenses, namely, the cancellation of the act that establishes administrative responsibility (clause 6, part 1 of article 247 of the Code of Administrative Offenses). The extreme importance of proper and clear settlement of all circumstances that exclude

proceedings in cases of administrative offenses is emphasized, because their application entails the impossibility of starting such proceedings or closing the initiated proceedings. We interpret the considered proceedings as broadly as possible: from the moment of the administrative investigation and initiation of the case and ending with the execution of the adopted decision. And closing the case at each stage has its own legal consequences: the later the case is closed, the more serious these consequences. It is noted that the simplicity of the circumstances, which excludes proceedings in cases of administrative offenses, provided for in clause 6, part 1 of Article 247 of the Code of Administrative Offenses appears only at a cursory examination, when due to the loss of their social harmfulness, actions are excluded from the list of actions that are administrative offenses. The article offered several problematic options for canceling the act that establishes administrative responsibility. First, one article of the Code of Administrative Offenses is repealed, and at the same time a new article regulating the same actions comes into force. At the same time, the specific act was and remains an administrative offense. Secondly, the abolition of administrative responsibility by acts that do not fall under the concept of "an act that establishes administrative responsibility" by changing subordinate legal acts for which the Code of Administrative Offenses establishes administrative responsibility. And, thirdly, in the case of criminalization of an act that is an administrative offense. That is, increasing the degree of public harm to the level of public danger and transferring this act to the category of a criminal offense. Taking into account the identified shortcomings, specific proposals are provided to improve the provisions of clause 6, part 1 of article 247 of the Code of Administrative Offenses.
LEGAL FRAMEWORK FOR VACCINATION IN PHARMACIES: THE EXPERIENCE OF EUROPEAN COUNTRIES
Authors: Pashkov Vitalii M. , Hnedik Yevhen S.
Published: April 2024

Overcoming infectious diseases provoked by military aggression from the Russian Federation presents new challenges for the state. It's not just about developing new vaccines or updating pharmaceutical production. Very often, shortcomings in organizing population vaccination are the reason for the delayed response in times of war. This is related not only to the ignorance of the experience of developed countries by the Ministry of Health of Ukraine but also, seemingly not essential, to the preparation of qualified personnel. It concerns the implementation of Directive 2005/36/EC of the European Parliament and of the Council of 7 September 2005 on the recognition of professional qualifications. In this case, it is about the training of pharmacists, who are considered medical professionals according to international classification. Unfortunately, in Ukraine, there is a clear distinction between medical and pharmaceutical professionals. As a result, pharmacists do not have the right to perform even the simplest duties that any medical professional has the right to perform. In our case, it is about population vaccination. In many developed countries, primary examination (diagnosis) of patients before vaccination can be performed by pharmaceutical professionals. The experience of Germany is quite significant in this regard. According to the Law on Pharmacies, specially trained pharmacists, with the availability of special equipment and premises, have the right to conduct the primary examination of patients and vaccinate them. Can this be done in Ukraine today? At first glance, yes, but with some restrictions. The point is that the level of knowledge that modern European pharmacists must possess is not always achievable for most Ukrainian pharmacists. The profession of a pharmacist requires a wide range of knowledge. Moreover, a European pharmacist becomes such only through full-time education. Unfortunately, the Ukrainian training system involves part-time education alongside full-time. Therefore, Ukrainian pharmacists, in many cases, cannot compete with foreign pharmacists from EU countries. This is why Ukrainian pharmacists cannot be trusted to perform the functions of medical professionals, including population vaccination.
PRECISION DESIGN OF PROTON EXCHANGE MEMBRANE FUEL CELL FLOW FIELD BASED ON WATER AND HEAT TRANSFER MECHANISM
Authors: Xiangrong Liao , Su Jianbin , Photong Chonlatee
Published: April 2024

The article establishes a three-dimensional multiphase proton exchange membrane single-cell model and investigates the impact of precision flow field design on the electrochemical characteristics, heat mass transfer properties, and phase change characteristics of fuel cells. The simulation model is analyzed using COMSOL 6.0 multiphysics software and validated using experimental data under the same operating conditions. The research results indicate that precision flow field design can enhance the electrochemical characteristics of proton exchange membrane fuel cells (PEMFC) by reducing concentration overpotentials through improved gas mass transfer, thus increasing the performance of cell. Precision flow field design improves gas and current density distribution uniformity, promoting more uniform electrochemical reactions and enhancing cell durability. Finally, precision flow field design increases gas mass transfer rates, effectively removing liquid water from the interior and facilitating smoother gas transport to the active regions. This study provides new insights into flow field design for fuel cells.
LASSBio Chemical Library Diversity and FLT3 New Ligand Identification
Authors: Franco Lucas , Maia Rodolfo , Barreiro Eliezer
Published: April 2024

This account describes the analysis of the Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio) chemical library as a valuable resource for early drug discovery studies. LASSBio has been using medicinal chemistry strategies for almost 30 years to design new prototype compounds with a focus on pharmacological activity. The LASSBio Chemical Library (LCL) is a collection of more than 2000 compounds, and the aim of this work was to characterize its chemical diversity and to perform a molecular repositioning study to identify ligands of feline McDonough sarcoma (FMS)-like tyrosine kinase 3 (FLT3), a validated target for leukemia treatment. To achieve this, cheminformatic tools were utilized to analyze the chemical diversity of the LCL. The analysis allowed the identification of the most representative compounds of this collection, showing that the N-acylhydrazone chemotype is present in approximately 50% of the compounds. Furthermore, the compounds in this chemical library demonstrated remarkable compliance with both the Lipinski’s (93% of the compounds) and Veber’s (96% of the compounds) rules. In the study on molecular repositioning, 10 compounds were selected through virtual screening to test their enzymatic inhibition of FLT3 kinase. Among them, 4-((6,7-dimethoxyquinazolin-4-yl)amino) benzamide (LASSBio-2166) (31) showed a half-maximal inhibitory concentration (IC50) = 194 nM. Optimization of the identified hit and further studies to compare the diversity of the LCL with other libraries are perspectives of this work.
Professional Language Competencies of Complex Rehabilitation Specialists in the System of Additional Professional Education
Authors: Vechkanova Irina , Loginova Ekaterina , Matveeva Marina , Rodin Evgeniy
Published: April 2024

The article introduces the conditions for the development and improvement of professional language competencies in complex rehabilitation specialists as part of additional professional education. The study covered the theory and practice of teaching foreign languages in the system of additional professional education for specialists in complex rehabilitation. It involved 76 students of advanced training and focused on the requirements for professional labor functions in the curriculum for social workers. The new teaching methodology improves complex rehabilitation skills aimed at extracting information from professional texts and developing a foreign language communicative competence. To overcome some difficulties in pronunciation, vocabulary, and grammar, the authors compared these issues with the speech of patients with disabilities and applied methods for correcting speech disorders, which increased the practice orientation in the future rehabilitation workers. The methodology included authentic foreign literature, professional community sites, modern information tools, and gaming technologies. Such interdisciplinarity expanded the vocabulary of specialists as it introduced them to the international professional terminology. The motivational and linguistic components were able to improve the language competence in complex rehabilitation specialists during their additional professional education.
Developing a Business Communication Culture in Law Students
Authors: Terehova Elena
Published: April 2024

At the present stage of management science and practice, the problem of business communication is associated with complex professional tasks and high professional requirements for employees. The article introduces some recommendations on the issue of developing business communication culture in students of law. Lawyers provide legal assistance, explain the meaning of the law, hold meetings, etc. The skill of effective business communication and business correspondence is important for them to provide various types of legal services. Oral and written business communication is one of the main problems of business speech development. The authors used the methods of case study, typical situations, projects, and teaching by action to define the problems of forming a culture of business communication in law students and develop recommendations to increase the effectiveness of the academic process. The lack of specialized disciplines in the curriculum affects the business communication development. A law student needs to learn how to use the basic models of speech activity, understand the speech logic, and master the legal vocabulary. They require events aimed at developing their communication skills, such as workshops on business ethics, debates, negotiations, group projects and various forms of team work, etc. Law students need to develop their personality and self-confidence to be able to take the initiative in their professional activities.
Some Aspects of Interaction in the System of Public Authorities in the Context of Trust Assurance
Authors: Gutorova Alla
Published: April 2024

People's trust depends not only on the deputies of the State Duma that represent regions or municipalities. However, the relevance of the problem is connected with the opposition between institutions of collegiate and individual people's delegates. This study featured the constitutional and sectoral norms that govern the public relations in the system of public authorities. The author used the perspective of trust assurance to study the constitutional and legal regulation of public authorities and local self-government within the framework of public authorities. The study involved general scientific and special methods, e.g., comparative legal and dogmatic analyses, and described the relations between the federal authorities, the state power, and the local self-government. The analysis revealed a set of norms that allows for a reasonable compromise between the constitutional principles of the separation of powers and the unity of the system of public power. The author believes that the non-achievement criterion used for assessing the performance of municipal authorities should be removed. The right to express confidence or distrust is a power that belongs to the people's representation. It has uncertain legal consequences and cannot be associated with obligatory removal from office, forced resignment, and other legal forms of early termination of powers.
Examining the spatial and temporal vulnerability to drought in Odisha, India
Authors: Modi Prakhar , Majhi Kriti Kiran , Gogineni Abhilash
Published: April 2024

The research focuses on investigating the spatial and temporal vulnerability to drought in Odisha, India, utilizing the Standard Precipitation Index (SPI), Drought Index (DI), and Rainfall Anomaly Index (RAI). The historical precipitation data are utilized to identify areas with prolonged rainfall deficits, quantifying the severity and duration of drought conditions. Preliminary analysis includes Normality and Homogeneity tests to ensure the validity of the precipitation datasets. The results depict the use of a non-parametric test for which Mann–Kendall trend test and Sen's Slope test are conducted. The districts exhibiting significant decreasing trends are identified as most critical for drought assessment. The findings from drought indices indicate that most districts have been affected by drought for approximately 50 years, with some districts experiencing severe or extreme conditions for over 10 years. Among the nine districts exhibiting a decreasing trend, four districts demonstrate a significant trend at a 5% significance level. These four districts are experiencing extremely and severely dry conditions, and while they display a significant decreasing trend, they are potentially vulnerable to the adverse impacts of drought conditions in the future. The study will serve in understanding and addressing the vulnerability to drought in Odisha, providing crucial insights for effective mitigation and management strategies.
Geospatial technique for the delineation of groundwater potential zones using multi-criteria-based AHP and MIF methods
Authors: Multaniya Amit Prakash , Sinha Manish Kumar , Sahu Kamal Kishor , Shubham
Published: April 2024

In the recent past, the growing climate change and transformation of the green cover into urban areas have posed a threat to natural water supply, which will have a direct impact on water demand for emerging cities such as Nava Raipur. As a result, the increasing demand coupled with the reduced availability of surface water prompts scientific investigation into groundwater availability and its sustainable management as an alternative. The study attempted to determine groundwater potential zones using the analytic hierarchy process (AHP) and multi-influencing factor (MIF) techniques. Twelve contextually significant regulating environmental factors were selected, and their significance and influences on decision-making approaches models have been attempted to determine through the sensitivity analysis. The final GWPZ map obtained, from a combination of thematic layers, was verified using the receiver operating curve (ROC) and the area under curve (AUC) with discharge (yield) records taken from 21 bore wells. According to the ROC curve's AUC estimation, MIF can explain 82.9% of the actual groundwater situation in the region, and for AHP, an AUC value of 0.751 is relatively low. This indicates that the MIF model is the most appropriate to accurately define potential groundwater zones for emerging cities like Nava Raipur.
Prevalence of Psychiatric Disorders among Patients with Granulomatosis with Polyangiitis (Wegener's) and the Predictive Role of Personality Traits
Authors: Mousavi Nazanin , Molaei Aghil , Alesaeidi Samira , Eftekhari Seas Nader , Effatpanah Mohammad
Published: April 2024

Background

Wegener’s disease is an autoimmune condition affecting the respiratory tract and kidneys. Mental health assessment is crucial due to the impact of psychological disorders on the immune system. Despite this, there is limited community-based research on psychiatric disorders and personality traits among patients with Wegener's disease.

Objective

This study aimed to investigate the prevalence of psychiatric disorders and examine the predictive role of personality traits among patients with Wegener's disease.

Methods

A total of 100 patients met the inclusion and exclusion criteria, and all of them were selected to participate in the study. Out of them, 75 individuals completed the questionnaires. The instruments included the SCL-90 questionnaire and the NEO Big Five personality traits. The data were analysed using Stata software, and the prevalence of psychiatric disorders in different patient groups was determined using the chi-square method. The predictive role of personality traits in mental disorders was examined using multivariate regression.

Results

The results revealed that paranoia (53.3%) and depression (44%) had the highest prevalence in terms of psychiatric disorders, while psychosis (17.3%) and hostility (25.33%) had the lowest prevalence. Additionally, the findings demonstrated a positive correlation between most psychiatric disorders and the neuroticism personality trait.

Conclusion

Given the influence of mental disorders on the immune system in Wegener's disease, it is essential to provide psychological care for these patients.
The Effect of Specific High-intensity Exercises on Cardiovascular Balance, Vascularity, and Performance in Female Youth Basketball Players
Authors: Mourgan Fatma Hassan Abd Elbasset , AlMatar Manaf , Al-Shamli Ali , Al-Kitani Mahfoodha , Al-Yaaribi Ali , Albarri Osman
Published: April 2024

Background

Sports training causes physiological changes in almost every body system; the more successfully these changes accomplish the functional adaptation required to execute the physical load effectively while conserving energy, the greater performance improvement may be anticipated. For training programs to be effective and boost performance in any sport, they must consider the nature and kind of the sport as well as a study of the performance conditions.

Methods

This research investigated how a 5-week, specially designed high-intensity interval training (HIIT) programme affected the aerobic ability of adolescent female basketball players. It also investigated how physical characteristics, skill qualities, heart impulse, oxygen distribution rates, and energy expenditure indices relate to one another. Lastly, research was conducted on the significance of urea-ketone energy consumption.

Results

A basketball-specific high-intensity training program lasting twelve sessions most likely reduced the time for the 20-meter speed test (Pre: 3.22 ± 1.72, Post: 3.02 ± 1.75 Sec) and improved the standing long jump test (Pre: 1.55 ± 0.49, Post: 1.65 ± 0.35 cm) and vertical jump test (Pre: 27.83 ± 6.40, Post: 31.42 ± 7.23 cm).

Conclusion

Oxygen uptake (VO2), VO2/Kg, carbon dioxide generation (VCO2), respiratory exchange ratio (RER), vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) were all positively impacted by the training sessions. After 12 sessions, young female basketball players' aerobic performance is improved with HIIT tailored specifically for basketball.
MiR-214-3p Regulates Apoptosis of Ameloblasts under Excessive Fluoride
via PI3K/AKT Signaling Pathway
Authors: Liu Xia , Fu Nanqing , Chen Bin , Wang Yueyue , Shu Xin , Liu Jianguo , Bai Guohui , Tian Yuan
Published: April 2024

Background

Excessive intake of fluoride during enamel growth and development can impair the normal physiological function of ameloblasts, resulting in the formation of dental fluorosis. However, little is known about the function of miRNAs in the formation of dental fluorosis.

Aim

This study aimed to explore the effects of key miRNAs on the PI3K/AKT signaling pathway and ameloblasts under high fluoride conditions.

Materials and Methods

LS8 cells were treated with NaF at concentrations of 0.4, 0.8, 1.6, 3.2, and 6.4 mmol/L for 24 h, and cell viability and apoptosis were measured using the CCK-8 assay and flow cytometry. The expression of apoptosis-related proteins was detected by Western blotting. Transcriptome sequencing was performed on FS8 cells after treatment with 1.6 and 3.2 mmol/L NaF for 24 h to identify key miRNAs and validate them. After cell transfection, the effect of miR-214-3p on ameloblasts and the PI3K/AKT signaling pathway was assessed.

Results and Discussion

NaF treatment significantly reduced the viability and accelerated the apoptosis of LS8 cells. The down-regulated miRNAs predicted target genes that were most enriched in the PI3K/AKT signaling pathway, and the most critical miRNA was miR-214-3p. The expression levels of p-PI3K, p-AKT, and Bcl-2 were significantly up-regulated after overexpression of miR-214-3p in LS8 cells, while the expression of PI3K, AKT, and Bax was significantly down-regulated, which was partially reversed by LY294002.

Conclusion

Excess fluoride could affect the morphology of ameloblast-like cell lines and induce apoptosis. Overexpression of miR-214-3p inhibited NaF-induced apoptosis in LS8 cells by regulating the PI3K/AKT signaling pathway, inhibiting its phosphorylation, down-regulating the Bax protein, and up-regulating the Bcl-2 protein.