bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-nucleotide polymorphisms of nucleotide excision repair genes and their association with overall survival in North Indian lung cancer patients treated with platinum-based doublet chemotherapy
Authors: Singh Sidhartha , Sharma Sidharth , Lawania Shweta , Singh Navneet
Published: June 2023

Background:

The aim of the study is to understand the association of Nucleotide excision repair (NER) inter-genetic polymorphic combinations with overall survival (OS) in lung cancer as well as its histological subtypes in the North Indian population.

Materials and Methods:

Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. For survival analysis, the univariate Kaplan–Meier and multivariate Cox regression model were applied. Recursive partitioning method, survival analysis tree was applied to study unfavorable genotypic combinations in NER single-nucleotide polymorphisms.

Results:

Combinatorial studies suggested no association between polymorphic combinations of NER genes and OS in lung cancer patients. When stratified as per lung cancer histological subtypes, adenocarcinomas patients with XPG 670 and XPC 499 polymorphism a significant increase in OS in combined heterozygous and mutant genotype with a lower hazardous ratio (Hazard Ratio1 (HR) = 0.20; P = 0.004). Small-cell lung carcinoma (SCLC) patients with XPF 11985A>G and XPD Arg156Arg polymorphism showed a 4-fold hazard ratio among heterozygous genotype (HR1 = 4.84; P = 0.007) where no significant results are obtained in patients suffering from squamous cell carcinoma histological subtypes. STREE showed XPG Asp1104His (W), XPD Lys751Gln (H + M), XPF Arg415Gln (H + M) genotype was associated with a lower hazard ratio (P = 0.0007) showing survival of 11.6 months when compared with the reference (median survival time = 3.52).

Conclusion:

It can be concluded that SCLC patients with polymorphic combinations of the NER pathway were associated with a higher risk of mortality. STREE depicted the association of NER polymorphic combinations with a lower hazard ratio predicting them to be a good prognostic factor for lung cancer.
XRCC3 and NBS1 gene polymorphisms modulate the risk of pre-oral cancer and oral cancer in the North Indian population
Authors: Nigam Kumud , Gupta Shalini , Singh Navin , Yadav Suresh Kumar , Sanyal Somali
Published: June 2023

Background:

Oral cancer is alarming disease in the developing countries like India. DNA repair capacity may affect by genetic polymorphisms in DNA repair genes and thus may cause to cancer. XRCC3 involves in homologous recombination repair pathway and repair DNA damage and crosslinks while, NBS1 participate in repair of double strand DNA break and starts the cell-cycle checkpoint signaling.

Aims and Objectives:

This study was to conducted to find the association of XRCC3, NBS1 polymorphisms with oral disease.

Materials and Methods:

This study included 230 patients of precancerous oral lesions (Leukoplakia 70, Oral Sub mucous fibrosis 90, Lichen Planus 70), 72 oral cancer and 300 healthy control samples and genotyping was done by PCR-RFLP methods. Chi-square test was used for calculation of genotype and allele frequencies. Odds ratio and P values were calculated with Epi-Info programme (http://wwwn.cdc.gov/epiinfo/).

Results:

TT genotype of XRCC3 was associated with high risk of precancerous lesions and oral cancerous lesions (P value=0.0001, OR=9.68, 95% CI=2.82-33.21; and P value=0.0001, OR=13.10, 95% CI=3.38-50.73 respectively). We did not observe any interactions of XRCC3 polymorphism with demographic parameters in influencing the risk of oral diseases. Variant allele genotypes (CG, GG) of NBS1 (C>G) polymorphism showed protective association with Oral submucous fibrosis (OSMF), lichen planus as well as oral cancer (OR=0.31, OR=0.01; OR=0.39, OR=0.03; OR=0.43, OR=0.31 respectively). Particularly, tobacco chewer with CG & GG genotypes were at decrease risk of oral diseases (P value=0.02, OR=0.32, 95% CI=0.12-0.80). Compared to CC/CC combined genotype CG/CC, CG/CT, GG/CC and CG/CT genotypes decreased the risk of oral disease (OR=0.05, 0.47, 0.26 & 0.14 respectively).

Conclusion:

This study concludes that SNP in XRCC3, NBS1 affects susceptibility to oral disease.
Clinicopathological and survival features of neuroendocrine tumors: A retrospective analysis of 153 cases, our current remarks on a heterogeneous tumor group, and still unmet future expectations
Authors: Kahraman Seda , Bardakci Murat , Aykan Musa B. , Yasar Serkan , Erol Cihan , Hizal Mutlu , Akinci M. Bulent , Kos Fahriye Tugba , Dede Didem S. , Karadurmus Nuri , Yalcin Suayib , Sendur Mehmet Ali N. , Yalcin Bulent
Published: June 2023

Objective:

Neuroendocrine neoplasms (NENs) originate from the diffuse neuroendocrine cell system and constitute a heterogeneous group of tumors exhibiting diverse clinical and biological characteristics. NENs include well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). In the present study, we performed a retrospective analysis of patients diagnosed with NET to evaluate clinicopathological characteristics, treatment and outcomes.

Material and Methods:

Data from 153 patients diagnosed with NET who were treated and followed up at three tertiary care centers from November 2002 to June 2021 were retrospectively evaluated. Clinicopathological and prognostic factors, treatment modalities and survival data were analyzed. Kaplan–Meier analysis was used to assess survival data and comparisons were performed using the logrank test.

Results:

Median age (IQR) was 53 (18–80) years. 85.6% of the patients had gastro-entero-pancreatic (GEP)-NET. The primary tumor was resected in 95 patients (62.1%) and metastasectomy were performed in 22 patients (14.4%). Seventy-eight patients received systemic therapy for metastatic disease. Patients were followed up for a median of 22 (IQR = 33.8) months. The estimated one-year and three-year survival rate was 89.8% and 74.4%, respectively. Median progression-free survival (PFS) were 10.1, 8.5, and 4.2 months after first-, second- and third-line therapy, respectively.

Conclusion:

The number of systemic treatment options and diagnostic tools for NETs has significantly improved in the last few years. NET classification, which treatment will be more appropriate for which group of patients, the molecular basis of this disease and the development of treatment strategies are open-ended questions that still need to be investigated.
Fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in the first-line treatment of metastatic gastric cancer: A single-center experience
Authors: Tastekin Didem , Paksoy Nail , Dogan Izzet , Ferhatoglu Ferhat , Khanmammadov Nijat , Bozbey Hamza U. , Karabulut Senem
Published: June 2023

Objective:

The median survival time for metastatic gastric cancer that has a poor prognosis is usually shorter than 1 year. The fluorouracil, oxaliplatin, and docetaxel (FLOT) regimen is observed to be effective in the neo-adjuvant treatment of gastric cancer. However, data on the FLOT regimen in metastatic gastric cancer are limited. The current study aims to evaluate the safety and efficacy of the FLOT regimen in metastatic gastric cancer in real life.

Study Design:

Retrospective study.

Place and Duration of Study:

The study was performed in an Institute of Oncology of a university and included the patients diagnosed between January 2015 and December 2020.

Methodology:

In addition to the clinicopathological data of patients with human epidermal growth factor receptor 2 (HER-2)-negative metastatic gastric cancer, we retrospectively evaluated the survival and treatment-related toxicities. The FLOT regimen (Fluorouracil 2600 mg/m2 24 hours continuous intravenous infusion, leucovorin 200 mg/m2, oxaliplatin 85 mg/m2, and docetaxel 50 mg/m2 on day 1) every 2 weeks was used in all patients.

Results:

The study included 94 patients who were followed up for a median of 11.1 (min–max: 1.5–65.8) months. The number of male patients was 60 (63.4%), and the median age was 58 (min–max: 27–78) years. The primary tumor was located in the stomach (72.3%) and gastroesophageal junction (27.7%). The objective response rate was observed in 64.8% of the patients. The median overall survival was 13.5 (95% CI: 9.2–17.8) months, whereas the progression-free survival was 7 (95% CI: 5.7–8.3) months. The 1-year survival rate was 53.6%. Complete response was detected in 7.4% of the patients. Among grade 3–4 toxicities, neutropenia (44.6%), leukopenia (27.6%), neuropathy (12.7%), and fatigue (9.5%) were the most common observed toxicities.

Conclusion:

FLOT is a highly active option in the first-line treatment of metastatic gastric cancer, with a favorable safety profile.
Feasibility of preirradiation temozolomide in cases of high-grade gliomas: Our experience and review of literature
Authors: Arora Savita , Rathi Arun K. , Singh Kishore , Ansari Faiz A.
Published: June 2023

Aim:

The purpose of this study was to evaluate the efficacy and safety of preradiation temozolomide (TMZ) in high-grade gliomas.

Study and Design:

It is a single-center, single arm, prospective study. The study included postoperative, histopatholgically proven cases of high-grade gliomas.

Materials and Methods:

Nine patients of anaplastic astrocytoma (AA) and twenty patients of glioblastoma multiforme (GBM) were enrolled in the study. All patients had undergone partial or complete resection. Three weeks after surgery, patients were started on chemotherapy, consisting of two cycles of TMZ, 150 mg/m2/day for 5 days, repeated at an interval of 4 weeks. Patients were subsequently treated with concomitant chemoradiotherapy. A dose of 60 Gy was given over thirty fractions along with TMZ, 75 mg/m2/day. Four cycles of TMZ were given after completion of radiotherapy, in a dose and manner similar to preradiotherapy.

Statistical Analysis and Result:

Treatment-related toxicity was assessed using common terminology for toxicity criteria (CTCAE v4). Progression-free survival and overall survival (OS) analysis was done. Nearly 79% of patients completed the two cycles of preradiation chemotherapy. Chemotherapy was tolerated well. Median time to progression was 11 months and 8.2 months in AA and GBM patients, respectively. Median OS was 17.4 months in AA patients and 11.4 months in GBM patients.

Conclusions:

Most patients of postoperative high-grade gliomas tolerated two cycles of TMZ. A good safety profile of TMZ allows it to be used in frontline settings, especially in high volume centers where a delay in starting radiotherapy frequently occurs. The use of TMZ before radiotherapy is a safe and feasible approach, and further studies are required to validate this approach.
Placental transfusion in the newborn
Authors: Nair P. M. C.
Published: June 2023

Placental transfusion refers to the transfer of residual placental blood (~30%–40%) to the baby during the first few minutes of birth. Increasing fetal hemoglobin by placental transfusion is an extremely effective method of enhancing arterial oxygen content, increasing cardiac output, and improving oxygen delivery. The advantages of placental transfusion for the baby and also the timing of cord clamping and various methods of umbilical cord clamping such as immediate or early cord clamping, delayed cord clamping (DCC) and its advantages, umbilical cord milking (UCM) both intact UCM or cut UCM, physiological-based cord clamping, and intact cord resuscitation (ICR) are discussed. The current International Liaison Committee on Resuscitation (ILCOR, 2020) and the Neonatal Resuscitation Program (NRP, 2021) guidelines on umbilical cord clamping recommend to DCC for 30–60 s for both term and preterm infants who do not require resuscitation. DCC and UCM are safe and easy to do and associated with various benefits. UCM is a good option to be practiced in moderate preterm/term nonvigorous infants and in lower segment caesarean section babies. The favorable outcome of UCM in nonvigorous babies requiring resuscitation and also the recent ICR at the mother’s bedside are discussed. UCM may offer an advantage over DCC in newborns who are deemed too unstable to wait for 30–60 s required for DCC. UCM can be performed in any low resource setting and provides adequate placental transfusion without delay. UCM is contraindicated in extreme preterms less than 29 weeks of gestation because of the risk of intraventricular hemorrhage. ICR might be the future in nonvigorous babies.
A case of cold agglutinin disease
Authors: Kuncheria Jo Martin , James Mary
Published: June 2023

Cold agglutinin disease is a form of autoimmune hemolytic anemia. There is production of antibodies directed against red blood cell and destruction by mononuclear phagocytic system or complement system. Clinical presentations are as follows: high-grade intermittent fever, vomiting, and loose stool with generalized abdominal pain. Urine output was decreased and was cola colored. Visible jaundice was present, and blood pressure was on higher side. Investigations showed severe anemia (Hb-5 g/dL), deranged renal function (145/3.2 mg/dL), elevated total (13 mg/dL) and direct bilirubin (7.6 mg/dL), and lactate dehydrogenase (1700 U/L), and peripheral smear showed features of hemolysis and direct Coombs test turned positive. Cold agglutination test was positive. The child was diagnosed to have cold agglutinin disease and was managed in warm environment and treated with methylprednisolone, antihypertensives, packed red cell transfusion, and hemodialysis.
Intracranial pial arteriovenous malformation in an infant treated with endovascular glue embolization
Authors: John Sangeetha R. , Sasidharan Bindusha , Hariharan Sankar V.
Published: June 2023

Intracranial pial arteriovenous fistulas (AVFs) are rare vascular malformation in children. Children usually present with macrocrania and localized neurological impairments, whereas infants typically present with congestive heart failure. Congenital pial AVF may have syndromic association with Rendu-Osler-Weber disease and Klippel-Trenaunay-Weber syndrome. Here, we are reporting the case of a 5-month-old child who presented with multiple episodes of seizures and magnetic resonance imaging brain revealed pial AVF from the left middle cerebral artery. Following digital subtraction angiogram, glue embolization was done and achieved complete obliteration of venous sac and flow across fistula. Child had an uneventful postoperative period and developed no complications.
Aplasia cutis congenita
Authors: Farsana A. T. , Remesh Preetha , Anand M. R. , Mathew Jim , Biju Muhammed
Published: June 2023

Aplasia cutis congenita (ACC) is a rare congenital condition characterised by the absence of some or all layers of the skin in a localized or widespread area at birth. It may also be associated with absence of underlying muscle and bone. The scalp is the most common site with 86% of cases occurring as solitary lesions found on the vertex or parietal areas. In this group of patients 20% of lesions involve failure of underlying bone development. Although most commonly seen on the scalp, aplasia cutis congenita can affect any part of the body, including the trunk and limbs. Where dura is exposed there exists a risk of ulceration, infection and haemorrhage and thus primary closure is indicated. We report a case of cutis aplasia successfully closed with opposing bipedicled flaps. This procedure offers a simple safe technique that can be applied in the neonate.
Evaluation of halitosis in patients with chronic obstructive pulmonary disease, chronic renal failure, and peptic ulcer
Authors: Fenn Saramma Mathew , Ravi Suganya , Mohan Karthik Rajaram , Thangavelu Ravikumar Pethagounder
Published: June 2023

Background:

Oral breath can be used as a chairside investigation method in the detection of volatile sulfur compounds (VSCs), which can serve as a potential biomarker in the early detection of underlying systemic diseases.

Aim:

The primary aim was to study the hydrogen sulfide levels in oral breath of patients with chronic obstructive pulmonary disease (COPD), chronic renal failure (CRF), and peptic ulcer disease.

Materials and Methods:

The study included 100 patients divided into four groups with 25 patients in each group of CRF, COPD, peptic ulcer, and control. The oral breath sample collected from each participant was passed through a sensor in the hydrogen sulfide detector (Tanita, Japan), which registers the level of sulfides. The maximum level attained was determined in parts per billion sulfide equivalents using direct readings from the monitor's digital display. The values obtained were statistically analyzed using statistical tests: Shapiro–Wilk test, analysis of variance, and post hoc analysis.

Results:

The mean values for the age and hydrogen sulfide scores were as follows: control group (35.16 ± 14.12 and 0.44 ± 1.00), CRF (49.16 ± 13.93 and 2.32 ± 0.98), COPD (48.16 ± 15.58 and 2.40 ± 0.95), and the peptic ulcer (42.36 ± 15.44 and 1.68 ± 1.02). The post hoc analysis for intergroup comparison of mean values reveals that statistically significant (P = 0.001*) differences exist between the control group and the CRF group, the control group and the COPD group, and the control group and the peptic ulcer group.

Conclusion:

The CRF group had slightly higher hydrogen sulfide measurements among the four groups, indicating the release of more VSCs.
Cancer drug resistance can be combated by targeting histone methyltransferases – A novel therapeutic approach
Authors: Sai Charan K. V. , Kumari M. , Nivedha K. , Aishwariya M.
Published: June 2023

Background:

Various experimental studies have proved that histone methyltransferases (HMTs) are responsible for tumor progression, and the use of inhibitors for the same opens new therapeutic approaches in the treatment of cancer.

Aim:

The purpose of this review was to appraise the basics of histones, HMTs, the classification of the HMT, and the mechanism of HMT in tumor progression and their inhibitors.

Materials and Methods:

This narrative review was carried out using an electronic search of the data for articles related to the basics of histone, classification of HMTs, their role in tumor progression, and the molecular inhibitors of HMTs from the following databases such as PubMed, Scopus, and Web of science.

Results:

On the basis of our literary search, we were able to locate 11 articles that fulfilled our criteria.

Conclusion:

The advancement in the invention of small molecular inhibitors of HMTs is becoming a cutting-edge area of drug development. Soon, the drugs in preclinical and phase I trials will be approved by the Food and Drug Administration for clinical use.
Pattern and indications for tooth extraction among patients attending dental clinic at federal medical center Gusau, Zamfara state, Nigeria
Authors: Kaura Abubakar Mohammad , Shehu Abubakar M. , Mujtaba Bala , Anas Bawa Tsafe , Jaafaru Rufai , Balarabe Sani Auwalu , Bamgbose Babatunde Olamide
Published: June 2023

Background:

The loss of teeth can impose a huge burden on both the patient and the health system as it requires gigantic effort, technical know-how, and on most occasions out-of-pocket expenditure to reestablish the lost functions and esthetics.

Aim:

The aim of this study was to highlight the indications and patterns of tooth extractions in the Dental Surgery Department, Federal Medical Centre, Gusau, Zamfara State, Nigeria.

Materials and Methods:

Retrospective study design was used by retrieving case folders of patients who had extractions within the study period and analyzing for age, gender, and type of tooth/teeth extracted as well as the indications for tooth extraction. Data were analyzed using SPSS software version 25 and <0.005 of the P value was considered statistically significant.

Results:

A total of 2992 extractions were carried out within the 4-year time frame with 53.8% of males and 46.2% of females. The mean age was 30.66 (±16.9) years. The indication for tooth extraction was dental caries and its sequelae 75.9%, followed by periodontal disease 9.1% and recurrent pericoronitis 7.3%, respectively. There was a statistically significant difference between gender and indication for extraction (P < 0.001, df = 5).

Conclusion:

Dental caries and periodontal disease were the principal indications for tooth extraction, whereas molar teeth extractions were the most common in the studied population irrespective of age and gender.
Effect of sound masking using child-friendly masker sounds on the perception of the dental drill noise in pediatric dental practice
Authors: Umamaheswari N. , Ravi Saranyan , John John Baby , Mohan Muthusamy Raj
Published: June 2023

Background:

Dental anxiety is significantly influenced by the fear and annoyance brought on by the sound of a dental drill. As a result, the welcoming atmosphere at pediatric dental offices is likely to entice young children to come in for examination and treatment.

Aim:

The aim of this study was to compare the masking effect of dental drill noise with the sound maskers on the annoyance rate of pediatric dental patients.

Materials and Methods:

To evaluate the stimuli in the annoyance experiment, 40 children (20 boys and 20 girls) were enlisted. As masker sounds, dragonfly and whistle sounds were chosen, and the functioning dental drill noise was blended with the original sound level. The participants rated each audio stimulus signal delivered to them in a random order, with the level of annoyance indicated by a color scale corresponding to the intensity of their psychological sense. The mean comparison between the acoustic stimuli was made using the Friedman's test. Based on gender, the mean comparison between acoustic stimuli was made using the Mann–Whitney U-test.

Results:

The mean annoyance rate of dental drill noise dragonfly sound and whistle sound was 4.83, 1.15, and 3.82, respectively. Gender has a significant effect on masking effect in nonacoustic factor outcomes.

Conclusion:

The dragonfly sound had the best impact and the most significant reduction in annoyance compared to the sound of the drill. Typically, girls felt more at ease around the dragonfly sound than boys did.
Attitude, bio-ethics, and communication skills in undergraduate dental education
Authors: Joshi Yatishkumar S , Vagha Sunita , Pisulkar Sweta Kale , Mishra Gaurav Vedprakash
Published: June 2023

Background:

With the need to strengthen conative domain competencies, the medical council has introduced the attitude, ethics, and communication (AETCOM) module in the new competency-based medical education. Similar competencies exist in the curriculum prescribed by the Dental Council of India (DCI).

Aim:

This study aimed to collect the data regarding the perception of dental interns and their awareness of the existing curriculum.

Materials and Methods:

Eighty-six interns of a single batch participated in the survey. The survey included declaration, voluntary consent, basic knowledge regarding curriculum, their perception regarding DCI and AETCOM competency, and their assessment. Collected data were presented descriptively in figures and scores of perception were analyzed using the single sample Student's t-test.

Results:

Out of the 78 competency statements, only two DCI competency statements and nine AETCOM competency statements had P values higher than 0.05.

Conclusion:

Students perceive the increased emphasis on preclinical work and minimal emphasis on interpersonal skills in the curriculum. Students lack confidence in research projects and practice management competency and need additional training after BDS for setting up a practice.
Ideal structure and pure infiniteness of inverse semigroup crossed products
Authors: Kwaśniewski Bartosz , Meyer Ralf
Published: June 2023

We give efficient conditions under which a

\mathrm{C}^*

-subalgebra

A\subseteq B

separates ideals in a

\mathrm{C}^*

-algebra

B

, and

B

is purely infinite if every positive element in

A

is properly infinite in

B

. We specialise to the case when

B

is a crossed product for an inverse semigroup action by Hilbert bimodules or a section

\mathrm{C}^*

-algebra of a Fell bundle over an étale, possibly non-Hausdorff, groupoid. Then our theory works provided

B

is the recently introduced essential crossed product and the action is essentially exact and residually aperiodic or residually topologically free. These last notions are developed in the article.
Calculus of Variations
Authors: Bronsard Lia , Székelyhidi Jr. László , Tonegawa Yoshihiro , Toro Tatiana
Published: June 2023

The Calculus of Variations is at the same time a classical subject, with long-standing open questions which have generated exciting discoveries in recent decades, and a modern subject in which new types of questions arise, driven by mathematical developments and emergent applications. It is also a subject with a very wide scope, touching on interrelated areas that include geometric variational problems, optimal transportation, geometric inequalities and domain optimization problems, elliptic regularity, geometric measure theory, harmonic analysis, physics, free boundary problems, etc. The workshop balances the traditional interests of past conferences with new emerging perspectives.
Complex Geometry and Dynamical Systems
Authors: Dinh Tien-Cuong , Marinescu George , Tosatti Valentino , Wulcan Elizabeth
Published: June 2023

The workshop focused on recent developments in holomorphic dynamics, several complex variables and complex geometry. The topics of the talks included dynamics of holomorphic and rational maps, the theory of currents, the Bergman kernel, together with applications in geometry, dynamics, foliations and mathematical physics.
Large Scale Stochastic Dynamics
Authors: Caputo Pietro , Toninelli Fabio L. , Tóth Bálint
Published: June 2023

The goal of this workshop was to explore the recent advances in the mathematical understanding of the macroscopic properties which emerge on large space-time scales from interacting microscopic particle systems. The talks addressed the following topics: randomness emerging from deterministic dynamics, hydrodynamic limits, Markov chain mixing times and cut-off phenomenon, superdiffusivity in out-of-equilibrium 2-dimensional systems.
An Action Research on Strengthening the Communication Skills of Foreign Children in the Context of Culturally Sensitive Education
Authors: YÜNCÜ Sevim , AKGÜL Esra
Published: June 2023

This study aims to strengthen the communication skills of foreign children within the scope of multicultural education, improve their language skills with the support of their peers, and support the adaptation process to school. In an independent kindergarten affiliated with the Ministry of National Education in Gaziantep, the study involved 22 Turkish, two foreign-born children, and the parents of those children. One of the qualitative research techniques used in the study was action research. The research's data collection methods included the sociometry scale, observation notes, home visits, family interviews, checklists, and document reviews. The process was cycled through until the achievements and indicators determined in the checklist were attained after the two-week observation period. Then the researchers developed an action plan. Achieving target achievements and indicators was completed by implementing a five-week action plan. At the end of the process, while the importance of a positive classroom climate, teacher support, and home visits were revealed, it was concluded that peer support significantly affected communication and language skills. In addition, the reflections of working in cooperation with the family were seen.
Yol Boyu Heyelanlarına Bir Örnek: Ardahan - Göle Heyelanı
Authors: AKDAĞ Dilek
Published: June 2023

Heyelan, ülkemizde depremlerden sonra en fazla meydana gelen bir afettir. Heyelanın yarattığı etkiler ise ciddi can ve mal kaybı ile sonuçlanmakta ve ülke ekonomisine ciddi zararlar vermektedir. Bu çalışma kapsamında Ardahan-Göle karayolunun 8. km’sinde meydan gelen Ardahan-Göle Heyelanı inceleme konusu olarak ele alınmıştır. Bu doğrultuda Ardahan-Göle Heyelanı ve çevresinde arazi çalışmalarıyla incelemeler yapılarak heyelanı tetikleyen unsurlar ile heyelanın morfometrik özellikleri belirlenmeye çalışılmıştır. Heyelanın haritalanması amacıyla İHA ile elde edilen görüntüler kullanılarak 2,5 cm yersel çözünürlüğe sahip ortofoto ve 10 cm yersel çözünürlüğe sahip sayısal yükselti modeli oluşturulmuştur. Toplanan veriler CBS ortamında işlenerek heyelanın haritası yapılmıştır. Öte yandan arazi çalışmaları sırasında alınan numunelere XRD analizi uygulanarak kayma yüzeyi gereçlerinin jeokimyasal yapısı ortaya konulmuştur. Bölgede heyelana duyarlı alanların tespit edilmesi için frekans oranı yöntemi ile heyelan duyarlılık analizi üretilmiştir. Elde edilen bulgulara göre; rotasyonel kayma tipi bir özellik gösteren Ardahan Göle Heyelanı karayolu genişletme faaliyetlerinin tetiklemesiyle meydana gelmiş ve akabinde yol yapımı çalışmalarında aksamalara neden olmuştur. XRD sonuçlarına göre kil minerallerine ait oranların yüksek olması heyelanın gelişmesinde rol oynamıştır. Antropojenik ve doğal süreçlerin bölgede yeni heyelanları tetiklemesi ihtimali göz önüne alınarak frekans oranı yöntemi ile heyelan duyarlılık analizi üretilmiş ve bu analizin sonucuna göre çok yüksek ve yüksek duyarlı alanların %33,11’lik bir alan kapladığı ortaya koyulmuştur.
Prática de análise linguística/semiótica no ensino fundamental: abordagem da storytelling como recurso
Authors: Duarte Corrêa Ana Cláudia , Sathler Sigiliano Natalia
Published: June 2023

Com o intuito apresentar uma pesquisa-ação, realizada no âmbito do PROFLETRAS, e apontar para formas de integração entre a prática de análise linguística e semiótica em ações didáticas de produção de textos multimodais, esta pesquisa assumiu a hipótese de que a abordagem de elementos linguísticos e semióticos prototípicos de gênero textual e/ou de seus recursos pode auxiliar no aprendizado da língua (SOUZA, 2021). Sob a perspectiva dos multiletramentos (ROJO, 2012) e da análise linguística (MENDONÇA, 2006; 2007), foram realizadas ações que visavam formar usuários reflexivos e críticos quanto ao uso da língua e das linguagens. Pautada em princípios da sequência didática (COSTA-HUBES; SIMIONI, 2014), a exploração do recurso da storytelling em publicidades e propagandas, durante a ação didática, revelou progresso dos estudantes quanto ao reconhecimento e ao uso de mecanismos de produção de textos multimodais, apontando para o êxito da perspectiva e da metodologia empregadas.
Predictive value of βhCG measured on day 11 after blastocyst embryo transfer for early pregnancy outcome
Authors: Phan Kieu Linh , Le Minh Tam
Published: June 2023

Objectives: To study the value of βhCG on day 11 after embryo transfer in predicting the early outcome of pregnancy after in vitro fertilization.

Materials and methods: A prospective descriptive study was examined on 148 cycles that satisfied inclusion criteria that the βhCG concentration at day 11 after IVF was higher or equal to 25mIU/ml. This research was conducted at Hue center for Reproductive Endocrinology and Infertility from December 2019 to July 2022. The cycles that met the inclusion criteria were followed up to 12 weeks of gestation. Comparing the variation of the βhCG level between different groups: biochemical/clinical pregnancy, singleton/multiple pregnancy, and ongoing pregnancy/early fetal loss. ROC curves were used to calculate the serum βhCG cutoff levels with maximum sensitivity and specificity to predict early pregnancy outcomes.

Results: The mean concentration of serum βhCG of clinical pregnancy was significantly higher than that of biochemical pregnancy (631.4 ± 433.6 mIU/ml vs 150.9 ± 182.8 mIU/ml); that of multiple pregnancy was significantly higher than that of singleton pregnancy (935.6 ± 460.6 mIU/ml vs. 558.3 ± 388.1 mIU/ml); and that of ongoing pregnancy was significantly higher than that of early fetal loss (619.4 ± 407.8 mIU/ml vs. 327.0 ± 159.1 mIU/ml). The serum βhCG level on day 11 after embryo transfer had a good value in predicting clinical pregnancy at the cutoff of  212.4 mIU/ ml (AUC = 0.900); a moderate value in predicting twin pregnancy at the cutoff of 537.8 mIU/ml (AUC = 0.774) and ongoing pregnancy at the cutoff of 501.3 mIU/ml (AUC = 0.742).

Conclusions: The serum βhCG level on day 11 after blastocyst transfer was a prognostic indicator for early pregnancy outcome after in vitro fertilization which included: clinical pregnancy, twin pregnancy and ongoing pregnancy.
Effectiveness of Inositol on clinical features, endocrine and metabolic profiles in infertile patients with polycystic ovary syndrome
Authors: Le Viet Nguyen Sa , Le Minh Tam , Tran Thi Nhu Quynh , Cao Ngoc Thanh
Published: June 2023

Objectives: This study aimed to assess the impact of Inositol on the clinical characteristics, endocrine and metabolic profiles of infertile PCOS patients from Vietnam.

Methods: From June 2018 to June 2022, a clinical trial was undertaken at the Center for Reproductive Endocrinology and Infertility on infertile women aged 18 to 40 with PCOS. The clinical, endocrine, and metabolic features of these individuals were assessed before and after 3 months of treatment with 2g of Inositol per day. Natural pregnancy rates, adverse effects, and tolerance of Inositol have also been recorded.

Results: After three months of Inositol treatment, 18.2% of patients with oligomenorrhea experienced regular menstruation. Inositol therapy dramatically lowered hips circumference and Testosterone levels, but had no effect on other clinical characteristics, endocrine profiles, or metabolic profiles. In the overweight and obese group, weight, BMI, waist and hip circumferences decreased dramatically while regular menstrual cycles were improving in non overweight/ obse group. 9.4% of patients reported experiencing side effects; despite this, 100% of women tolerated Inositol and maintained treatment. 18.9% of them attained pregnancy, which resulted in 17% live births.

Conclusion: Inositol appears to increase menstrual cycle regularity and decrease Testosterone levels; resulting in a clinical pregnancy rate of 18.9% and a live birth rate of 17.0%. Inositol appears to be more beneficial in improving weight, BMI, waist and híp circumference in the obese and overweight population.
STUDY OF APPLICATION PROCESS OF DAMPING COATINGS MADE OF POLYMERS AND METALS
Authors:   Belarusian National Technical University, SHELEG Valerij K. , MA Min ,   Belarusian National Technical University, BELOTSERKOVSKY Marat A. ,   Joint Institute of Mechanical Engineering of the NAS of Belarus, LEVANTSEVICH Mikhail A. ,   Joint Institute of Mechanical Engineering of the NAS of Belarus
Published: June 2023

The processes of obtaining damping polymeric coatings (gas-flame spraying of powders) and composite metal coatings (deformation cladding with a flexible tool) are studied. It is established that coatings applied by the gas-flame method with thermoplastic polymer powders provide a sufficiently high damping efficiency, while the best dissipative characteristics are provided when sprayed with polyethylene terephthalate powder. The maximum adhesion strength (10.5–10.7 MPa) for normal separation of coatings applied with polyethylene terephthalate powder is achieved when using a combustible mixture with a propane/air ratio of 1:26 and subsequent cooling at a rate of no more than 3 deg/s. Based on the results of tribotechnical tests, the composition of sintered bronze-graphite was selected for applying noise-absorbing coatings by the deformation cladding method. The study of the influence of regime parameters of the cladding process on the thickness and continuity of the formed coating layer of bronze-graphite showed that the ratio of the linear speed of movement of the workpiece and the linear speed of rotation of the brush should be within 0.23–0.27, the interference value N — in the range of 0.8–1.5 mm with the number of passes n = 8–12. The microhardness of the clad layer was H0,049 = 1,700 MPa, which exceeded the microhardness of the donor material by 25 %.
CORROSION-MECHANICAL FATIGUE: THE PROBLEMS OF FORECASTING. PART 2. REVERSE EFFECT. INFLUENCE OF STRESSES ON THE CORROSION RATE
Authors:   S&P GROUP TRIBOFATIGUE LTD, SOSNOVSKIY Leonid A. , BOGDANOVICH Alexander V. ,   Belarusian State University, SHERBAKOV Sergey S. ,   Presidium of the National Academy of Sciences of Belarus
Published: June 2023

Corrosion is one of the main electrochemical processes that damage metal materials. The combination of cyclic stresses and a corrosive environment causes wear-fatigue damage, called corrosion-mechanical fatigue. The paper investigates the problem of predicting this type of wear-fatigue damage, which occurs in almost all branches of technology, especially in the chemical, oil, metallurgical industries, transport. The work consists of several parts. In the first part a technique for estimating the fatigue limit in a given corrosive environment (direct effect) is developed. The second part analyzes the reverse effect, i.e. the effect of acting stresses on the corrosion rate of metals and alloys, and proposes a method for predicting corrosion-erosion damage with the reverse effect based on the energy criterion. In the future, it is planned to discuss the mechanisms of corrosion-mechanical fatigue with direct and reverse effects at different stages of complex damage.
The Impact of Using Social Media on the Mental Health of Adolescents
Authors:   Ramkhamhaeng Advent International School, Bangkok, Thailand, Titisuk Panupong , Vajarapongse Yanin ,   Panyarat High School, Bangkok, Thailand, Thongwon Lalitpat ,   Saparachinee Trang School, Trang, Thailand
Published: June 2023

Social media usage has exponentially risen over the past decade, with about 4.26 billion social media users in 2021, and it is projected to increase to almost 6 billion by 2027. The COVID-19 pandemic has accelerated this trend, leading to a significant increase in social media usage. However, excessive social media use may lead to negative impacts on mental health, such as anxiety, depression, and social isolation. This research aims to investigate the impact of social media on the mental health of Thai teenagers, identify potential correlations between social media use and mental health outcomes, and develop strategies to mitigate the negative effects of social media on mental health. The questionnaires gather the participants’ general information, the effects of utilizing social media, and the social media events that affect their mental health. With a total of 272 respondents, a survey distributed online to high school students from March 26 to May 6 was randomly chosen. According to our study, the type of school has a significant effect on the student’s mental health. This is due to the fact that different high school students use social media in different ways and experience different effects on their mental health in both positive and negative ways. Statistics also reveal that youths in Thailand are more likely to be addicted to social media and use a variety of social media platforms. This study could serve as a guideline for further studies that specifically focus on the kinds of social media platforms used by adolescents and the kinds of content they consume.
Cultural Study of Natural Environment Exploitation: Eating Culture of the Joseon People through the Novel “Thousand-Year Kingdom”
Authors:   Faculty of Languages and Social Science - Ba Ria - Vung Tau University, Viet Nam, Nguyen Tam, Minh , Tran Thuy, Thi ,   Faculty of Languages and Social Science - Ba Ria - Vung Tau University, Viet Nam, Tran Kiet, Tuan ,   Faculty of Languages and Social Science - Ba Ria - Vung Tau University, Viet Nam, Nguyen Ha, Thi Thu ,   Faculty of Languages and Social Science - Ba Ria - Vung Tau University, Viet Nam
Published: June 2023

The novel “Thousand-Year Kingdom” by Kim Kyung-uk is based on a true story from history when three Dutch sailors drifted into Joseon in the 17th century. Through the narrative of Jan Jansz Weltevree – the first Westerner to set foot in Joseon-the life, society, and people of Joseon are perceived and described in a fresh and unfamiliar way, different from the evaluations of Koreans or Easterners. This study focuses on investigating the cultural utilization of the natural environment by the Joseon people in this unique literary work to understand the uniqueness of their eating culture.
Long-Term Effects of Taking Refractive Surgery (LASIK) on Thai People
Authors:   Chulalongkorn University Demonstration Secondary School, Bangkok, Thailand, Kurattanasinchai Kawisara , Dumumpai Thitanan ,   amsen Wittayalai School, Bangkok, Thailand, Booncharoen Pakkapol ,   Assumption Samutprakarn School, Samut Prakarn, Thailand
Published: June 2023

Nowadays, the number of people who have a visual impairment tends to increase moderately because they spend much more time using smartphones for both work and personal use. The monitors of phones, tablets, and computers have blue light, which directly affects the eyes. Thus, many people need to wear glasses or contact lenses, but not everyone is appropriate to do so. If patients ignore it, their visual impairment might be worse. So, having refractive surgery is one of the popular solutions to grappling with this sight problem. Nevertheless, LASIK may also have negative consequences, such as dry eyes and itchy eyes. Therefore, understanding the risks and being aware of the effects of refractive surgery would greatly impact a person’s choice for eye correction. Consequently, we conducted this survey research using questionnaires in order to determine the long-term effects and satisfaction of taking refractive surgery for Thai patients. Our results show that there are various side effects and different levels of side effects on each person. Therefore, this study will provide guidelines for making the decision to undergo refractive surgery or not.
The use of artificial intelligence in international commercial arbitration in South Africa: prospects and challenges
Authors: Okorley Solomon
Published: June 2023

Sedert die opkoms van kunsmatige intelligensie is die impak daarvan in die meeste sektore van die ekonomie gevoel, wat die gesondheidsektor, media en kommunikasiesektor, finansies, landbou en, mees opvallend, die motorbedryf insluit. Dit word gemanifesteer in die vervaardiging van outonomiese voertuie wat as noodsaaklik beskou word in die Vierde Nywerheidsrevolusie. Die regsprofessie is geen uitsondering tot die impak van kunsmatige intelligensie nie. Suid-Afrika se strewe om kunsmatige intelligensie in sy ekonomie te integreer, word gesien in die vestiging van die Presidensiële Kommissie oor die Vierde Industriële Rewolusie. Suid-Afrika se oogmerk om die voorkeur bestemming te wees vir die oplossing van internasionale kommersiële geskille via arbitrasie het gelei tot die afkondiging van die Wet op Internasionale Arbitrasie 15 van 2017. Hierdie artikel oorweeg die gebruik van kunsmatige intelligensie in internasionale handelsarbitrasie in Suid-Afrika. Dit kan die vorm aanneem van kunsmatige intelligensie wat óf as die arbiter óf as deel van die arbitrasiepaneel dien. Daarbenewens kan kunsmatige intelligensie-gebaseerde toestelle help met die arbitrasieproses, soos: die keuse van arbiters; die samevatting en analisering van partye se indienings en die wet; regsnavorsing en die opstel van arbitrasie-uitsprake. Die beoogde probleme wat met hierdie inisiatief gepaard gaan, sluit in die skep van tegnologiese werkloosheid, die probleem van vooroordeel, delegering en moeilikheid in die toewysing van aanspreeklikheid. Om hierdie probleme op te los, word aanbeveel dat die huidige regsraamwerk van internasionale kommersiële arbitrasie gewysig word om kunsmatige intelligensie in sy regsargitektuur op te neem. Op nasionale vlak sal dit die wysiging van die Wet op Internasionale Arbitrasie behels. Alternatiewelik kan die Modelwet van die Verenigde Nasies se Kommissie vir Internasionale Handelsreg van 1985 op internasionale vlak gewysig word om hierdie moontlikheid te weerspieël. Daar is ook die behoefte aan die opvoeding van burgers oor kunsmatige intelligensie, die toerusting van die werksmag met kunsmatige intelligensie-vaardighede, en die belegging in kunsmatige intelligensie-infrastruktuur. Dit sal help om die volle voordele van die gebruik van kunsmatige intelligensie in internasionale kommersiële arbitrasie te benut en die struikelblokke wat met hierdie innovasie gepaard gaan te verminder.
Çevre Okuryazarlığı ile İlgili Yapılan Lisansüstü Tezlerin İncelenmesi
Authors: UYGUN Kamil , KARABULUT Şifa
Published: June 2023

Çevre eğitimi, örgün öğretimde “çevre okuryazarlığı becerisi” adıyla öğretim programlarında karşımıza çıkmaktadır. İnsanların bilinçlenmesi amacı taşıyan bu beceri ile ilgili yapılan bilimsel çalışmalar oldukça önem teşkil etmektedir. Bu nedenle bu çalışmanın amacı, çevre okuryazarlığı ile ilgili yapılmış olan lisansüstü (yüksek lisans, doktora) tezleri incelemektir. Nitel araştırma yöntemi kullanılarak gerçekleştirilen bu çalışmada veriler doküman inceleme tekniği ile toplanmıştır. Çalışma, 2012-2022 yılları arasında hazırlanan lisansüstü tezleri kapsamaktadır. Bu çalışmaya 41 lisansüstü tez dahil edilmiştir. Çalışmaya dahil edilen tezlere Yüksek Öğretim Kurulu Ulusal Tez Merkezi veri tabanından erişilmiştir. Tarama terimi olarak “çevre okuryazarlığı” yazılarak arama yapılmıştır. Lisansüstü tezler; yıl, tez türü, çalışma alanı, yöntem, çalışma grubu, veri toplama aracı, amaç ve çalışma sonucu açısından incelenmiştir. Toplanan bu veriler betimsel analize tabi tutularak çözümlenmiştir. Araştırma sonucunda, çevre okuryazarlığı konusunda hazırlanan lisansüstü tezlerin çoğunluğu yüksek lisans düzeyinde, fen bilimleri alanında, öğrenci çalışma gruplarıyla ve nicel yöntemlerle hazırlanmıştır. Ulaşılan sonuçlar ışığında, bu araştırmaya paralel olarak, farklı alanlarda benzer çalışmalar yapılması önerilmiştir.
Marketing Strategy Of Jeruju (Acanthus Ilicifolius) Tea Products In Harapan Mandiri, Kebumen, Central Java
Authors: Adi Catur Pramono , Soeprijadi Lilik , Aripudin Aripudin , Arifiana Alya Nida Marbella
Published: June 2023

The problem that Harapan Mandiri is facing is the lack of consumer buying interest in original Jeju tea products. For this reason, Harapan Mandiri is able to change this condition through product innovation using additional ingredients such as ginger and rosella flowers in the hope of attracting consumer interest. The purpose of this research is to make innovative products to increase sales turnover. The results of the study show the following business analysis: With an investment cost of 6,032,000, fixed costs 2,060,000, variable costs 4,660,000, total expenses 6,720,000/month, revenue costs Rp. 15,000,000, profit/loss Rp. 7,240,000, R/C ratio 2.07, B/C ratio 1.07, BEP price 6,720, BEP production 265 packs. The marketing strategy carried out by Harapan Mandiri in developing its business products is by promoting products more frequently to various community association forums so that people are more familiar with Jeju tea products with the addition of ginger and rosella flowers, always updated with the times so as not to be left behind by market competition. by developing flavor variants in tea and updating packaging to make it more attractive to consumers' purchasing power, collaborating with partnerships so that they can increase marketing relations and collaboration in advancing business and building public trust by maintaining quality taste and product quality.