bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multi-level Hypoglycemia Early Alarm System Based on Sequence Pattern Mining
Authors: Yu Xia , Ma Ning , Yang Tao , Zhang Yawen , Miao Qing , Tao Junjun , Li Hongru , Li Yiming , Yang Yehong
Published: October 2020

Background: Early alarm of hypoglycemia, detection of asymptomatic hypoglycemia, and effective control of blood glucose fluctuation make a great contribution to the treatment for diabetic patients. In this study, we designed a multi-level hypoglycemia early alarm system to improve the overall performance of hypoglycemia early alarm. Methods: Through symbolizing the historical CGM data, the Prefix Span was adopted to obtain the early alarm and non-alarm frequent sequence libraries of hypoglycemia. The longest common subsequence was used to remove the common frequent sequence for achieving the hypoglycemia early alarm on the clinical dataset. Frequent sequence pattern libraries with different risk levels were designed by choosing different thresholds and a multi-level hypoglycemia early alarm system for different clinical situations were established. Results: The model was able to predict hypoglycemia events in the clinical dataset of level-I (sensitivity 85.90%, false-positive 23.86%, miss alarm rate 14.10%, average early alarm time 20.61min), level-II (sensitivity 80.36%, false-positive 17.37%, miss alarm rate 19.63%, average early alarm time 27.66min), and level-III (sensitivity 78.07%, false-positive 13.59%, miss alarm rate 21.93%, average early alarm time 33.80min), respectively.Conclusions: The proposed approach could effectively predict hypoglycemia events on the basis of different thresholds to meet different prevention and treatment requirements in clinical situations. Moreover, the experimental results confirm the practicality and prospects of the proposed early alarm system, which reflects further significance in personalized medicine for hypoglycemia prevention.
The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) Basic Training Course: Evaluation in China
Authors: Wang Jingjing , Li Lin , Xuan Yinghua , Wang Li , Wu Qingqing
Published: October 2020

BackgroundThe aim of this study is to evaluate effectiveness of ISUOG (International Society of Ultrasound in Obstetrics and Gynecology) basic training curse in Chinese sonographer, which has not been reported yet. MethodsISUOG basic training course includes 30 lectures and was held in 3 days in 2019 in Beijing, China. We included the questionnaires answered by the trainees both before and after the course in each day. There were 9 lectures presented in the first day, 12 in the second and 9 in the last. The theoretical tests were provided by ISUOG, including 22, 21 and 21 multiple-choice questions respectively in 3 days. Pre and post-training theoretical test scores were compared by Wilcoxon singned-rank test. The changes of the theoretical test scores and the rates of “very satisfied” and “very useful” from trainees of different professional titles were compared by Wilcoxon singned-rank test and Chi-square test.ResultsQuestionnaires from 481 trainees who have experience of ultrasonic scan in Ob/Gyn and also had done the survey both before and after course were collected, with 274 in the first day, 94 in the second and 113 in the last. The differences of the correct-answer-number got from the before-test and after-test were with statistically significance(all P-values <0.05). The trainees who got better scores after the training were 219(79.9%), 73(77.7%) and 82(72.6%) in each day, and the changes of scores were without significant difference between doctors of different titles( all P-values >0.05). After every day’s training, the rates as “very satisfied” evaluated by trainees were 81.4%, 87.2% and 91.1% respectively, and the rates as “very useful” were 80.3%, 88.3% and 91.2%. The rate of “very useful” evaluated by trainees of primary title was higher than that of high title, with P-values of 0.01.ConclusionOur results indicated that ISUOG basic training course in China got good feedback and could assist Chinese sonographers in some degree.
Persian Version of the Barkin Index of Maternal Functioning (BIMF): A Cross-Cultural Adaptation and Psychometric Evaluation
Authors: Ansariniaki Mehri , Lamyian Minoor , Ahmadi Fazlollah , Foroushani Abbas Rahimi , Curry Carolann L. , Barkin Jennifer L.
Published: October 2020

BackgroundPostpartum maternal functioning has the potential to affect the quality of interaction between mother and child. A proper assessment of maternal functioning requires a comprehensive and accurate tool. The objective of this study was to prepare a Persian version of the Barkin Index of Maternal Functioning (BIMF) and evaluate its psychometric properties in order to determine its applicability in Iranian mothers.MethodsThe BIMF was translated into Persian and then culturally adapted for Iranian women. After evaluating face and content validity, a cross-sectional study was conducted using the Persian version of BIMF. The data was collected from two unique groups of 250 mothers (in all 500 mothers); the women had infants who were 2 to 12-months old and were selected using a two-stage cluster sampling method. Factor analysis, Pearson’s correlation, intra-class correlation coefficients (ICC), composite reliability (CR) and Cronbach’s alpha were employed in order to evaluate structural validity and reliability.ResultsExploratory factor analysis resulted in a five-factor structure consisting of 20 items. Subsequently, confirmatory factor analysis (X ²/ df= 1.61, RMSEA = 0.050, GFI = 0.91, CFI = 0.91) confirmed that the Persian version had satisfactory goodness of fit. Reliability and internal consistency were confirmed with a CR of 0.77, an ICC of 0.87 and a Cronbach's alpha of 0.81.ConclusionsThe findings indicated that the Persian version of the BIMF is a valid and reliable instrument for assessing maternal functioning among Iranian mothers.
Usefulness of Intraoperative C-Arm Image Intensifier in Reducing Errors of Acetabular Component During Primary Total Hip Arthroplasty: An Application of Widmer’s Method
Authors: Song Joo-Hyoun , Kim Yong-Sik , Kwon Soon-Yong , Lim Young-Wook , Jung Jiyoung , Oh Seungbae
Published: October 2020

BackgroundAcetabular prosthesis positioning in total hip arthroplasty (THA) is crucial in reducing the risk of dislocation. There has been minimal research on the proper way to put the acetabular components into the safe zone intraoperatively. Assessment of version by intraoperative imaging intensifier is very valuable. The value of Widmer’s method, using the intraoperative C-arm available to determine cup anteversion was assessed.Methods101 hips in 91 patients who underwent primary THA were eligible for inclusion. Utilizing intraoperative C-arm images, measurement was performed using the technique described by Widmer. The values obtained using 3D computed tomography postoperatively, which determined the anteversion of the acetabular component, were regarded as the reference standard.ResultsThe method of Widmer obtained values similar to those obtained using 3D computed tomography and was considered accurate (n.s.). All 101 hips were positioned in the set target zone. Among the 101 hips, the cup position in nine hips (8.9%) was changed. The dislocation rate in our study was 1.0% with all dislocations occurring in hips placed in the target zone. The mean Harris hip score after THA in one year was 94.2 (82-98).ConclusionsThe method of Widmer was accurate using intraoperative imaging intensifier for the measurement of the anteversion of the acetabular component during THA, with reference to the anteversion obtained from the 3D computed tomography. Also, utilizing intraoperative C-arm imaging was very useful because it allowed for correction of the position of the acetabular cup.
FCN3 Is a Prognostic Biomarker Correlated with Immune Response in Liver Cancer
Authors: Lu Zhongxiao , Wu Jian , Li Yi-ming , Chen Wen-xiang , Yu Qiang-feng , Zhou Jian-Yin
Published: October 2020

AimLiver cancer is a common malignant tumor whose molecular pathogenesis remains unclear. This study attempts to identify key genes related to liver cancer by bioinformatics analysis and analyze their biological functions.MethodsThe gene expression data of the microarray were downloaded from the Gene Expression Omnibus(GEO) database. The differentially expressed genes (DEGs) were then identified by the R software package “limma” and were subjected to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses using DAVID. The protein-protein interaction (PPI) network was constructed via String, and the results were visualized in Cytoscape. Modules and hub genes were identified using the MCODE plugin, while the expression of hub genes and its effects were analyzed by GEPIA2. Additionally, the co-expression of the hub gene was explored in String, while the GO results were visualized using the R software. Finally, the targets of the hub gene were predicted through an online website. ResultsIn total, 43 differentially expressed genes were obtained. The GO analysis was mainly concentrated in the redox process and nuclear mitosis, while the KEGG pathway analysis was mainly enriched in retinol metabolism and the cell cycle. Moreover, four hub genes were identified in the PPI network, however, the Kaplan-Meier risk curve showed that only ECT2 and FCN3 affected the survival of liver cancer. ECT2 was found to be high expressed in liver cancer, carrying out signal transduction and targeting hsa-miR-27a-3p. FCN3 was observed to be lowly expressed in liver cancer and related to the immune response, targeting hsa-miR132-5p.ConclusionThe obtained findings suggest that two genes are significantly related to the prognosis of liver cancer, and the analysis of their biological function provided novel insight into the pathogenesis of liver cancer. Furthermore, FCN3 may serve as a promising biomarker for patients with liver cancer.
The Diagnostic and Prognostic Values of MicroRNA-196a in Cancer
Authors: Xiong Mengqiu , Wang Ping , Pan Bei , Nie Junjie , Wang Shukui , He Bangshun
Published: October 2020

BackgroundmicroRNA-196a (miR-196a) was previously reported to be upregulated in cancers, and has the diagnostic and prognostic values in cancers. Whereas, the conclusion was still unclear according to the published data. To assess such a role of miR-196a in cancers, this study was conducted based on published data. MethodsTo identify the relevant published data, we searched articles in databases and then the relevant data was extracted to assess the correlation between miR-196a expression and diagnosis and survival for cancer patients, all data was analysis with the statistical software STATA. ResultsThe pooled results showed that miR-196a was a valuable diagnostic biomarker in cancer (AUC=0.87, 95%CI: 0.84-0.90; sensitivity=0.73, 95%CI:0.64-0.81; specificity=0.90, 95%CI:0.81-0.95), which was consistent with the data from databases (breast cancer: miR-196a-3p: AUC=0.77, 95%CI: 0.74-0.79; miR-196a-5p: AUC=0.71, 95%CI: 0.66-0.75; pancreatic cancer: miR-196a-3p: AUC=0.80, 95%CI: 0.73-0.87; miR-196a-5p: AUC=0.61, 95%CI:0.51-0.71). In addition, miR-196a in tissues was an unfavorable survival prognosis biomarker (HR=2.54, 95%CI: 1.79-3.61, PHeterogeneity =0.000, I2=75.8%) and serum or plasma (HR=4.06, 95%CI: 2.67-6.18, PHeterogeneity =0.668, I2=0%), which was consistent with the data from databases (adrenocortical carcinoma: HR=5.70; esophageal carcinoma: HR=1.93; brain lower grade glioma: HR=2.91; GSE40267: HR=2.47, 95%CI: 1.2-5.07; TCGA: HR=1.82, 95%CI: 1.21-2.74; GSE19783: HR=4.24, 95%CI:1-18.06). ConclusionOur results demonstrated that miR-196a acts as a tumor suppressor with prognostic and diagnostic values for cancer.
Impact of Rhythm-control Therapy for New-onset Atrial Fibrillation in Critically ill Patients : A Post Hoc Analysis From the Prospective Observational AFTER-ICU study
Authors: Yoshida Takuo , Uchino Shigehiko , Sasabuchi Yusuke , Kyo Michihito , Igarashi Takashi , Inoue Haruka
Published: October 2020

BackgroundSustained new-onset atrial fibrillation (AF) is time-dependently associated with hospital mortality. However, whether rhythm-control therapy can achieve sinus rhythm (SR) restoration in critically ill patients is unknown. This study aimed to assess the impact of rhythm-control therapy on SR restoration in critically ill patients with new-onset AF.MethodsThis study is a post hoc analysis of the AFTER-ICU study, a prospective observational study of patients with new-onset AF in 32 Japan intensive care units. This study included patients with and without rhythm-control therapy with new-onset AF. A multivariable analysis was performed using Cox proportional hazards regression analysis including rhythm-control therapy as a time-varying covariate for SR restoration.ResultsOf 423 patients with new-onset AF, 178 (42%) underwent rhythm-control therapy. Among those patients, 131 (31%) underwent rhythm-control therapy within 6 hours after AF onset. Magnesium sulfate was the most frequently used rhythm-control drug. The Cox proportional hazards model for SR restoration showed that rhythm-control therapy had a significant positive association with SR restoration (adjusted hazard ratio: 1.46; 95% confidence interval: 1.16–1.85). The rhythm-control group had higher hospital mortality than the non-rhythm-control group (31% vs. 23%, P=0.09).ConclusionsRhythm-control therapy for new-onset AF in critically ill patients was associated with SR restoration. However, patients with rhythm-control therapy had poorer prognosis, possibly due to selection bias. These findings may provide important insight for the design and feasibility of interventional studies assessing rhythm-control therapy in new-onset AF.Trial registrationUMIN-CTR UMIN000026401
Identification of Key Genes and Molecular Mechanisms Associated With Docetaxel Resistance in Castration Resistant Prostate Cancer Based on Bioinformatics Analysis
Authors: Liu Yu , Hu Changpeng , Zhang Qian , Liu Wuyi , Li Guobing , Tang Qin , Li Pantong , Lai Wenjing , Zhou Min , Liu Yali , Sheng Fangfang , Huang Jingbin , Zhou Huyue , Leng Faning , Li Furong , Zhang Rong , Zhao Yu
Published: October 2020

BackgroundCastration resistant prostate cancer (CRPC) is one of the most common solid tumor with high mortality and limited therapeutic options, and docetaxel is the first-line chemotherapy for patients. However, the long-term use of docetaxel has limited its clinical applications. The aim of this study was to identify docetaxel-resistant key genes and molecular mechanisms. ResultsTUBB4A (Class IVa beta-tubulin), SRPX (Sushi repeat containing protein, X chromosome) and CSRP2 (Cysteine and glycine rich protein 2) were finally identified as the key genes tightly related to docetaxel resistance. TUBB4A and CSRP2 may participate in docetaxel resistance by E2F transcription factor and MYC proto-Oncogene in the process of cell cycle, and SRPX may participate in docetaxel resistance by epithelial–mesenchymal transition (EMT) and P53 pathway. ConclusionTUBB4A, SRPX and CSRP2 may be the key genes associated with docetaxel resistance, which could be prognostic biomarkers for docetaxel resistance in CRPC.
CoPart: A Context-based Partitioning Technique for Big Data
Authors: Migliorini Sara , Belussi Alberto , Quintarelli Elisa , Carra Damiano
Published: October 2020

The MapReduce programming paradigm is frequently used in order to process and analyse huge amount of data. This paradigm relies on the ability to apply the same operation in parallel on independent chunks of data. The consequence is that the overall performances greatly depend on the way data are partitioned among the various computation nodes. The default partitioning technique provided by systems like Hadoop or Spark, basically performs a random subdivision of the input records, without considering the nature and correlation between them. Even if such approach can be appropriate in the simplest case where all the input records have to be always analysed, it becomes a limit for sophisticated analyses that imply correlations between records that can be exploited to preliminary prune unnecessary computations.In this paper we propose a partitioning technique which exploits the notion of context for partitioning data. We design a context-based multi-dimensional partitioning technique, called \copart, which considers not only the correlation of data w.r.t. contextual attributes, but also the distribution of each contextual dimension in the dataset. We experimentally compare our approach with existing ones, considering both quality criteria and the query execution times.
Applying the electronic nose for pre-operative SARS-CoV-2 screening
Authors: Wintjens Anne G.W.E. , Hintzen Kim F.H. , Engelen Sanne M.E. , Lubbers Tim , Savelkoul Paul H.M. , Wesseling Geertjan , Palen Job A.M. van der , Bouvy Nicole D.
Published: October 2020

Background: Infection with SARS-CoV-2 causes Corona Virus Disease (COVID-19). The most standard diagnostic method is reverse transcription-polymerase chain reaction (RT-PCR) on a nasopharyngeal and/or an oropharyngeal swab. The high occurrence of false-negative results due to the non-presence of SARS-CoV-2 in the oropharyngeal environment renders this sampling method not ideal. Therefore, a new sampling device is desirable. This proof-of-principle study investigated the possibility to train machine-learning classifiers with an electronic nose (Aeonose) to differentiate between COVID-19 positive- and negative persons based on volatile organic compounds (VOCs) analysis.Methods: Between April and June 2020, participants were invited for breath analysis when a swab for RT-PCR was collected. If the RT-PCR resulted negative, presence of SARS-CoV-2 specific antibodies was checked to confirm the negative result. All participants breathed through the Aeonose for five minutes. This device contains metal-oxide sensors that change in conductivity upon reaction with VOCs in exhaled breath. These conductivity changes are input data for machine-learning and used for pattern recognition. The result is a value between -1 and +1, indicating the infection probability.Results: 219 participants were included, 57 of which COVID-19 positive. A sensitivity of 0.86 and a negative predictive value (NPV) of 0.92 were found. Adding clinical variables to machine-learning classifier via multivariate logistic regression analysis, the NPV improved to 0.96. Conclusions: The Aeonose can distinguish COVID-19 positive from negative participants based on VOC patterns in exhaled breath with a high NPV. The Aeonose might be a promising, non-invasive, and low-cost triage tool for excluding SARS-CoV-2 infection in patients elected for surgery.
A Method to Access a Decimal Network (IPV9) Resource
Authors: Liu Guangzhou , Yu Fuya
Published: October 2020

Network security is highly valued by world leaders. The current Internet technology core is IPv4, IPv6, completely controlled by the United States. On December 14, 2017, the US Federal Communications Commission (FCC) formally abolished the net neutrality law. At that time, the Internet took on an obvious political color and posed a serious threat to Internet applications in various countries. China’s economy is already highly dependent on the Internet, and if the network is disrupted, the whole country will suffer heavy losses. The decimal Network Standard working Group of The Ministry of Industry and Information Technology of China and The Decimal Network Information Technology Co., LTD of Shanghai have been researching on the future network for more than 20 years. Developed a complete set of decimal network framework system, completed the future network series research and development with China’s independent intellectual property rights, and built the second Internet network system besides the United States. The technology has been fully tested in many places and achieved good results, truly achieving the goal of “autonomy, safety, high speed and compatibility”. This paper will introduce the method of accessing decimal network resources in the current network environment.
Technology for the development and implementation of social projects: substantiation of the project proposal and documents
Authors: Ahramakova Nataliia , Honcharova Svitlana , Honcharov Andriy
Published: October 2020

Ensuring a decent standard of living for citizens, especially vulnerable groups, requires qualitative changes in society. Social projects are a modern tool for making change. In this regard, it becomes relevant to study the applied aspect of their implementation – technology for the development and implementation of social projects. This study aims at exploring the nature and classification of social projects, as well as improving and further developing the technology for the development and implementation with justification of the project proposal and documentation using the Let’s Start Together project as an example. The object of research is the process of using technologies for the development and implementation of social projects in solving social problems of society. The subject is theoretical and practical recommendations on the technology for the development and implementation of social projects, based on the justification of the project proposal and documentation. The following methods were used: logical analysis – to clarify the essence of the concept of a social project; analysis and synthesis – to improve the classification of social projects; network planning – to formulate a technology implementation plan for the development and implementation of social projects. The paper explores the essence of a social project, proposes the classification of social projects and defines criteria for their evaluation. The sources of financing a social project are characterized; co-financing by various donors. A technology for the development and implementation of social projects is proposed. Considerable attention is paid to the first stage, namely the development of the project proposal and the documentation of a social project. The proposed technology was tested in the context of the social project Let’s Start Together.
Expression of gene involved in the response to abiotic factors in Capsicum annuum
Authors: Ríos Molina Dafne Alejandra , Aquino Medina Edgar Querubín , Couoh Uicab Yeny L. , Guevara Olvera Lorenzo , Silva Martínez Guillermo A. , Acosta García Gerardo , Ramírez Medina Humberto
Published: October 2020

Introduction: Abiotic stress caused by cold or water-deficit alters many cellular processes that modificate the physiology and biochemistry of plants, which reduces yield of agricultural crops.  Gibberellins are phytohormones that can induce growth and development of the plants. There are many genes whose transcription is modified during abiotic stress or by exogenous-gibberellins application; some of them encode for proteins such as LEA that confer protection against low temperature and dehydration, WRKY and FT that take part in the response to abiotic stress, FT that regulates the flowering time, and GA20ox1 that synthesized gibberellins. The understanding of molecular mechanism that regulates the plant responses to abiotic stress or exogenous gibberellins application is essential for Capsicum annuum (pepper) agriculture improvement. To this aim, we have proceeded to study the effect of biotic stress and exogenous phytohormones on C. annuum development, mainly in fruit (chili) production and expression of genes involved in the response to these conditions.Method: The genome of Capsicum annuum contains homologues to the proteins LEA, WRKY, FT and GA20oxy, so we estimate by Real-Time PCR (qPCR) and phenotype analysis, the gene expression and fruits production in plants grown under abiotic stress and after treatment with exogenous gibberellins.Results: The transcripts of CaLea73 and CaWRKY40 increased by cold stress in leaves.  While, CaGA20ox1 expression was down-regulated by cold stress, GA3, and hydric stress-GA3 in leaves.  This effect was also observed in flower buds of plants grown under water-deficit, treated with gibberellins or hydric stress-GA3; curiously, the transcripts from this gene became slightly abundant in plants grown under water-deficit. CaFT transcription was induced by cold stress and GA3 in leaves and flower buds, respectively; however, transcription of this gene was almost abolished by hydric stress and GA3–hydric stress in both tissues. Cold stress and exogenous phytohormones raised the fruits production.Conclusion: According with these results, we propose that cold treatment induces the plant defense mechanisms through activation of transcription factors like WRKYs and LEA proteins and increases the plant development through induction of signaling pathway of FT. Our study contributes to understanding on molecular mechanisms governing the responses to abiotic stress and the participation of the gibberellins in C. annuum development and to improve the yield of the chili crop.
Backpack use as an alternative water transport method in Kisumu, Kenya
Authors: Kim Sunkyung , Curran Kathryn , Deng Li , Odhiambo Aloyce , Oremo Jared , Otieno Ronald , Omore Richard , Handzel Thomas , Quick Robert
Published: October 2020

In developing countries, most households transport water from distant sources, placing physical burdens on women and children, who commonly carry water on their heads. A lightweight backpack was developed to alleviate physical stress from water carriage and provide a safe storage container. In 2015, we conducted a baseline survey among 251 Kenyan households with children <5 years old, distributed one backpack per household, and made 6 monthly home visits to ask about backpack use. At baseline, the median reported water collection time was 40 minutes/round trip; 80% of households reported collecting water daily (median 3 times/day). At follow-up visits, respondents reported backpack use to carry water ranged from 4% to 20% in the previous day; reported backpack use for water storage in the previous day ranged from 31% to 67%. Pain from water carriage was reported at 9% of all follow-up visits. The odds of backpack use in the past day to collect water were lower during rainy season (OR: 0.3, 95% CI: 0.2–0.3) and not associated with reported pain (OR: 1.7, 95% CI: 0.9–3.3). Our study suggests that participants preferred using the backpacks for storage rather than transport of water. Further dissemination of the backpacks is not recommended because of modest use for transport.
Treatment of high viscosity fracturing flowback by electrolytic brine-catalyzed oxidation
Authors: Si Shaoxiong , Gong Zhaobo , Yang Yongxia , Liu Shengli , Wang Yu , Wang Xinghua
Published: October 2020

With the increasing application of hydraulic fracturing technology in exploration of tight oil and shale gas, the treatment of accompanying fracturing flowback fluids has become more urgent. Fe/Ni catalyst was successfully applied in the treatment of the flowback fluid for the first time in this paper. The effects of different oxidants and catalysts on the treatment of fracturing flowback were investigated. Electrolytic brine was an optimal oxidation gel breaker and molecular sieve loaded with Fe/Ni as catalyst for the treatment of fracturing flowback. Fe/Ni catalyst was characterized by SEM, EDS analysis, TEM and XRD, and the catalytic effect of the Fe/Ni proportion was explored. Fracturing flowback that dealt with catalytic oxidation was mixed with polyaluminum chloride (PAC) and polyacrylamide (PAM) for flocculation and sedimentation, through a filter, and was continuously treated for 20 days to simulate on-site operation. Finally, the suspended solids (SS) content of the fracturing flowback was steadily less than 15 mg/L, which meets the reinjection standard of fracturing flowback (SY/T 5329-2012 (China)). Hence, electrolytic brine-catalyzed oxidation treatment of high viscosity fracturing flowback possess broad application prospects.
Gestão de Pessoas em Bibliotecas Universitárias:
Authors: Nogueira Anízia Maria Lima , Bernardino Maria Cleide Rodrigues
Published: October 2020

A pesquisa aborda a gestão de pessoas em bibliotecas universitárias trazendo uma proposta de atuação. A problemática está embasada no seguinte questionamento: Como formular uma proposta de atuação para gestão de pessoas aplicada a bibliotecas universitárias? Possui, como objetivo, abordar a gestão de pessoas na biblioteca universitária visando à elaboração de uma proposta de atuação. Quanto aos procedimentos metodológicos, a pesquisa caracteriza-se, quanto aos fins, como exploratória; quanto aos meios, como bibliográfica; e quanto ao tratamento dos dados, como qualitativa. Através do estudo, elaboramos uma proposta para atuação em bibliotecas universitárias com técnicas de gestão de pessoas, visando auxiliar os bibliotecários gestores na construção de ações estratégicas para o gerenciamento de suas equipes de trabalho. Conclui-se, então, que a proposta de atuação é baseada nos seguintes aspectos: liderança, seleção de pessoal, administração de conflitos, práticas de feedbacks assertivos, treinamento e capacitação de pessoal, habilidade de delegar, aplicação da gestão da transparência e elaboração de um plano de gestão.
Processo de captação de conhecimento
Authors: Santos Aguinaldo Ferreira , Razzolini Filho Edelvino
Published: October 2020

O objetivo deste texto foi verificar como indústrias de transformação no Estado do Paraná, que utilizam o Sistema Toyota de Produção, realizam o processo de captação e retenção de conhecimento dos seus colaboradores. O que embasa e justifica o estudo é a importância que existe em conhecer o cenário em que as empresas estão inseridas, seus concorrentes, suas dificuldades e pontos de melhoria. Para atingir o objetivo e esclarecer o problema proposto adotou-se uma metodologia quantitativa, com dados primários obtidos pela pesquisa aplicada e dados secundários obtidos da observação das empresas através de sítios on-line. O estudo foi realizado em indústrias de transformação, com mais de vinte funcionários, no Estado do Paraná. Em relação aos resultados verificou-se que os respondentes, de uma forma geral caracterizam a empresa em que trabalham como um potencial captador das informações em forma de conhecimento adquirido e, ainda, que são registrados para uso futuro, em forma de “lições aprendidas”. Restou evidenciado que as empresas respondentes da pesquisa utilizam de ferramentas para captar e reter o conhecimento de seus colaboradores. Além disso, foi possível caracterizar as empresas como facilitadoras de ambientes de troca de conhecimento entre os funcionários, pois existe disponibilização de espaços para a socialização dos funcionários, como preconiza o modelo SECI de Nonaka e Takeuchi (1997). Por fim, a pesquisa evidenciou que os respondentes apontam suas empresas como “facilitadoras” da gestão do conhecimento e sua respectiva conversão, aplicando o modelo SECI de gestão do conhecimento.
A comparative evaluation of surface water quality standards for lakes and fish
ponds from Bucharest and vicinity
Authors: Vasile Scaeteanu Gina , Madjar Roxana Maria , Stravescu-Bedivan Mala-Maria
Published: October 2020

Monitoring of lakes and ponds water quality parameters is important to evaluate the interactions between quality and effects on aquatic organisms’ growth and health. Even if each water parameter individually may not be relevant, several parameters together can reveal dynamic processes that occur in the water. For instance, unbalanced pH values may increase ammonia and hydrogen sulfide toxicity. Nitrogen and phosphorus are associated with plant and algae growth, although phosphorus is generally the limiting nutrient in freshwater bodies. Accordingly, it is recommended to monitor and assess water quality parameters based on routine analyses. Therefore, the aim of this study was to generate an overview of our researches related to the monitoring of water quality collected from lakes and fish ponds. The parameters on the basis of which was evaluated the quality of water were: pH, electrical conductivity (EC), total hardness (TH), chemical oxygen demand (COD), nitrate-nitrogen (N-NO3-), nitrite nitrogen (N-NO2-), ammonium nitrogen (N-NH4+), phosphate phosphorus (P-PO43-).
Tetralone Scaffolds and Their Potential Therapeutic Applications
Authors: Gauni Bhagwati , Mehariya Krunal , Shah Anamik , Duggirala Srinivas Murty
Published: October 2020

Substituted tetralones have played a substantial role in organic synthesis due to their
strong reactivity and suitability as a starting material for a range of synthetic heterocyclic compounds,
pharmaceuticals along with biological activities as well as precursors of many natural
products and their derivatives. Many α-tetralone derivatives are building blocks that have been used
in the synthesis of therapeutically functional compounds like some antibiotics, antidepressants,
acetylcholinesterase inhibitors effective for treating Alzheimer’s disease and alkaloids possessing
antitumor activity. In this review, there has been an attempt to explore the small molecule library
having an α-tetralone scaffold along with their diverse biological activities. Structural features of α-
tetralone derivatives responsible for potential therapeutic applications are also described.
Multi-Target Directed Compounds with Antioxidant and/or Anti- Inflammatory Properties as Potent Agents for Alzheimer’s Disease
Authors: Papagiouvannis Georgios , Theodosis-Nobelos Panagiotis , Kourounakis Panos N. , Rekka Eleni A.
Published: October 2020

Background:

Alzheimer’s Disease (AD) is one of the most common neurodegenerative
disorders, characterized by memory deficits and cognitive impairment. Acetylcholinesterase inhibitors,
NMDA receptor antagonists and nootropic agents are used clinically, but they have only symptomatic
efficacy, attributed to the multifactorial character of AD. The multi-target directed compound
approach is gaining attention and has been under investigation lately.

Objective:

This review selects several research articles, which describe the design, synthesis and biological
evaluation of multi-targeting molecules combining antioxidant or/and anti-inflammatory
properties. Compounds with these properties are expected to be beneficial in the treatment of AD.

Methods:

This review summarizes the pathobiochemistry of AD as well as the role of oxidative stress
and inflammation in the progression of neurodegeneration. It presents novel compounds with antioxidant
or/and anti-inflammatory activity that have been tested for their efficacy in neurodegenerative
disorders.

Results:

Various researchers have taken advantage of the multi-targeting drug approach in order to
design molecules which may be developed as useful agents for the treatment of neurodegeneration.

Conclusion:

The multi-targeting compound approach is a developing therapeutic strategy for multifactorial
diseases, such as AD, and can offer effective agents for their radical treatment.
Postmarketing Surveillance of In-vitro Diagnostic System in the European Union
Authors: Himadri Singh
Published: October 2020

Advances in medical device technology and regulatory authorization adapt to changing
requirements and market conditions. The assessment of safety and performance in the real-world
scenario will help us understand clinical benefits and help in the evolution of the medical device
and in-vitro diagnostic devices. The paradigm shift in the evaluation of medical devices and in
vitro diagnostic devices will ensure that the device delivers intended benefits. This article discusses
the new approach of the post-marketing surveillance in the context of new in vitro diagnostic regulation
in the European Union.
aproximación conceptual de los procesos cognitivos y su implicancia en la determinación de la comprensión lectora
Authors: Cupe Cabezas William Victor , Caballero Montañez Robert Chistian , Remuzgo Barco Luis Antonio , Maldonado Alegre Fernando Camilo
Published: October 2020

El Ministerio de Educación del Perú expresa la necesidad de reflexionar sobre la forma ideal y adecuada del logro de las habilidades comunicativas de los estudiantes. Entre ellas, que se establezcan mecanismos cognitivos que garanticen la comprensión a cabalidad de cualquier tipo de texto. Generalmente, en la educación básica regular y universitaria se evalúa -por medio de interrogantes- si el estudiante puede comprender un texto eficazmente a través de la resolución de preguntas con alternativas múltiples en el área de Letras. Sin embargo, no se evidencia un proceso gradual y cognitivo ni una clasificación sobre los tipos de textos más utilizados. En ese sentido, la finalidad del presente artículo es explicar una aproximación conceptual de los procesos cognitivos, la teoría de una estructura tipológica textual y las clases de preguntas que se presentan en textos de lectura en general. Se empleó una metodología de la comprensión de la teoría y de análisis de contenido conceptual. Así como también se ofrece una visión y reflexión sobre la problemática de la comprensión lectora en el país.
Evaluación de los factores geográficos que inciden en los flujos turísticos de la parroquia rural de Alangasí.
Authors: Molina Velásquez Edison Rubén , Sinchi Alba Danny Israel , Baquero Padilla Paula Andrea
Published: October 2020

El presente estudio se realizó con la finalidad de evaluar los factores geográficos que inciden en los flujos turísticos de la parroquia rural de Alangasí, perteneciente al Distrito Metropolitano de Quito, Pichincha, Ecuador. La valoración por medio de la metodología propuesta permitió el reconocimiento del espacio turístico y la relación espacial en el entorno turístico de la localidad; a su vez se identificó el medio natural y antrópico y su influencia en la población. En base a todo esto se determinó que Alangasí paisajísticamente se ha modificado por las diferentes actividades antrópicas y usos del suelo, y que así mismo está configurado como un sitio de recreación de paso con poca pernoctación y serias falencias en la prestación de servicios turísticos; pero que goza de una fuerte cohesión social entre sus habitantes en lo que respecta la organización de sus festividades.
Public Opinion About E-Cigarettes on Chinese Social Media: A Combined Study of Text Mining Analysis and Correspondence Analysis
Authors: Wang Di , Lyu Joanne Chen , Zhao Xiaoyu
Published: October 2020

Background

Electronic cigarettes (e-cigarettes) have become increasingly popular. China has accelerated its legislation on e-cigarettes in recent years by issuing two policies to regulate their use: the first on August 26, 2018, and the second on November 1, 2019. Social media provide an efficient platform to access information on the public opinion of e-cigarettes.

Objective

To gain insight into how policies have influenced the reaction of the Chinese public to e-cigarettes, this study aims to understand what the Chinese public say about e-cigarettes and how the focus of discussion might have changed in the context of policy implementation.

Methods

This study uses a combination of text mining and correspondence analysis to content analyze 1160 e-cigarette–related questions and their corresponding answers from Zhihu, China’s largest question-and-answer platform and one of the country’s most trustworthy social media sources. From January 1, 2017, to December 31, 2019, Python was used to text mine the most frequently used words and phrases in public e-cigarette discussions on Zhihu. The correspondence analysis was used to examine the similarities and differences between high-frequency words and phrases across 3 periods (ie, January 1, 2017, to August 27, 2018; August 28, 2018, to October 31, 2019; and November 1, 2019, to January 1, 2020).

Results

The results of the study showed that the consistent themes across time were comparisons with traditional cigarettes, health concerns, and how to choose e-cigarette products. The issuance of government policies on e-cigarettes led to a change in the focus of public discussion. The discussion of e-cigarettes in period 1 mainly focused on the use and experience of e-cigarettes. In period 2, the public’s attention was not only on the substances related to e-cigarettes but also on the smoking cessation functions of e-cigarettes. In period 3, the public shifted their attention to the e-cigarette industry and government policy on the banning of e-cigarette sales to minors.

Conclusions

Social media are an informative source, which can help policy makers and public health professionals understand the public’s concerns over and understanding of e-cigarettes. When there was little regulation, public discussion was greatly influenced by industry claims about e-cigarettes; however, once e-cigarette policies were issued, these policies, to a large extent, set the agenda for public discussion. In addition, media reporting of these policies might have greatly influenced the way e-cigarette policies were discussed. Therefore, monitoring e-cigarette discussions on social media and responding to them in a timely manner will both help improve the public’s e-cigarette literacy and facilitate the implementation of e-cigarette–related policies.
Immigrant Latino Fathers’ Perceptions of Child Abuse and Neglect
Authors: Kohli Hermeet K. , Fineran Susan
Published: October 2020

The objective of this qualitative research was to study the lived experiences of child abuse and neglect for immigrant Latino fathers whose children are involved in the child protection process. We documented the narratives of nine immigrant Latino fathers attending fatherhood groups regarding their perceptions of child abuse and neglect.The immigrant Latino fathers highlighted their lack of agency and marginalization due to acculturative parenting stress, structural discrimination, and immigration status. They are burdened with physical and emotional pain that diffuses into their children’s lives and results in unhealthy coping strategies. The Latino fathers faced everyday microaggressions, racial abuses, and discrimination due to their agency and role as Latino immigrants. They chronicled their frustrations dueto distrust of the mainstream social service providers, police, immigration officials, and abuse meted on them due to their marginalized identities. We provide practice and policy recommendations for professionals working with immigrant Latino families.
The Criminalization of Immigration and Intellectual Disability in the United States
Authors: Ricciardelli Lauren A. , Nackerud Larry , Quinn Adam E.
Published: October 2020

Public attitudes, negative stereotypes, and stigma are essential to cultural narratives about the membership status of people with intellectual disability and people who have immigrated to the United States. With a concern for the exclusion of people from participation in democratic societies, this mixed methods study explores conceptual links between the criminalization of intellectual disability and immigration. The overlay of criminal justice norms and practices onto civil law without parallel adoption of safeguards results in the misallocation of risk to individuals with out-group membership status. This study offers conceptual analysis by applying to the policy issue, standard of proof of intellectual disability in death penalty cases, the framework of membership theory and related constructs present in the scholarly literature on immigration policy. Exact measures logistic regression is used to predictively link states’ standards of proof of intellectual disability with immigration status. It was found that the best model predicting the probability of a Higher than Preponderance standard of proof of intellectual disability in death penalty cases was a two-variable model consisting of Prior Ban and Unauthorized Immigration. This study presents recommendations for research and policy practice.
Integrating Social Determinants of Health Into Clinical Training During the COVID-19 Pandemic
Authors: Solá Orlando , Marquez Crystal
Published: October 2020

Introduction: Social determinants of health (SDOH) are often incorporated to some degree within preclinical medical education, but no validated curriculum exists for the incorporation of SDOH and the competencies necessary to address nonclinical contributors to health, within clinical educational programming. The COVID-19 pandemic provided an opportunity to implement this programming in a virtual setting.
Methods: Using pedagogy developed by Freire and Dewey, we created a service-learning curriculum supported by reflection sessions, workshops on implicit bias, and journal clubs. We used flipped classroom and adult-learning theory to develop and implement this curriculum.
Results: Learners showed significant enthusiasm for this novel curriculum, identifying the incorporation of SDOH and related competencies in clinical education as unique and imperative, requesting that the content be further integrated within the clinical experience of State University of New York Downstate Health Sciences University.
Conclusion: We developed a service-based curriculum that succeeded in developing further understanding of how patients experience their health in Central Brooklyn, and provided a space for students to generate emotional and interpersonal expertise that is important for the growth of clinicians in caring for patients in underserved and underresourced communities.
UGD ve MOX Yakıtı Kullanılarak VVER-1000 Nükleer Reaktöründe Nötronik Ve Termal Performansın İncelenmesi
Authors: UZUN Sinem , GENÇ Yasin , ACIR Adem
Published: October 2020

Nükleer güç reaktörlerinin güvenlik ve tasarım özellikleri incelenirken nötronik karakteristiklerinin yanı sıra termal performansları da önemlidir. Bu çalışmada, iki farklı yakıt demeti düzenine sahip VVER-1000 reaktörünün nötronik ve termal performansları incelenmiştir. YD1 ve YD2 olarak isimlendirilen bu yakıt demeti düzenleri sırasıyla %3,7 zenginlikli LEU ve %3,6 zenginlikli LEU ile %4 Gd2O3Uranyum-Gadolinyum (UGD) bileşimi ve %2, %3, %4,2 Pu ve %3,6 zenginlikli LEU ile %4 Gd2O3 içeren (MOX) yakıt bileşiminden meydana gelmektedir. UGD ve MOXGD yakıt kullanımının kritiklik ve yanma sonunda yakıt bileşimi değişimleri üzerine etkileri MCNP5 ve MONTEBURNS2.0 nükleer kodu yardımıyla incelenirken COBRA-IV PC termal analiz kodu yardımıyla sıcak kanal boyunca soğutucu akışkana ait sıcaklık ve entalpi değişimleri irdelenmiştir. Bu çalışmadan elde edilen sonuçlar literatürde yer alan benzer çalışmalarla karşılaştırılmış ve ulaşılan bulguların literatürle uyum içerisinde olduğu görülmüştür.
Técnicas emergentes de extracción de β-caroteno para la valorización de subproductos agroindustriales de la zanahoria (Daucus carota L.): una revisión
Authors: Otálora-Orrego Daniel , Martin G. D. A.
Published: October 2020

El objetivo de la presente revisión es reunir, contrastar y analizar algunas de las técnicas convencionales y no convencionales de extracción de β-caroteno a partir de la zanahoria (Daucus carota L.), a través de un análisis bibliométrico de estudios e investigaciones recientes, en los que confluyen numerosas técnicas, parámetros y hallazgos. Asimismo, establecer las posibles contribuciones de la extracción con solventes verdes para estos procesos, permitiendo su aplicabilidad a escala industrial para el aprovechamiento de los subproductos agroindustriales de este vegetal. La zanahoria es rica en carotenoides, en especial β-caroteno, fuente de provitamina A, utilizada como colorante natural en la industria de alimentos y farmacéutica. La extracción asistida con microondas (MAE por su sigla en inglés), con enzimas (EAE por su sigla en inglés) y en fluidos supercríticos (SFE por su sigla en inglés), han sido evaluadas en la zanahoria y comparadas con las técnicas convencionales de extracción (CSE por su sigla en inglés), encontrando rendimientos y eficiencias similares e incluso superiores. Sin embargo, la extracción asistida con ultrasonido (UAE por su sigla en inglés), muestra resultados satisfactorios y considerablemente mayores (157,0 mg b-caroteno/100 g base seca). Se requieren estudios posteriores para optimizar las condiciones y los parámetros de extracción, y evaluar las condiciones de conservación de la materia prima y del extracto final que aseguren una mayor estabilidad del producto y, por ende, un rendimiento de extracción superior, al igual que considerar alternativas verdes de extracción para reducir el impacto ambiental.