bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of Performance Properties of Dyed and Raised Twill Woven PES/VIS Fabrics by Full Factorial and Taguchi Experiment Design Methods
Authors: SABIR Emel Ceyhun , ÖZGÜR Ertan
Published: July 2023

In this study, full factorial experimental design and Taguchi experimental design for the optimization of selected fabric quality parameters were examined comparatively with an experimental study. The aim of the study is to show that Taguchi Experimental Design can be used instead of Full Factorial Experimental Design, which is a classical experiment plan in textile engineering studies. In the experimental study developed in outerwear woven fabric dyeing-finishing enterprises; The woven fabric in three different twill forms, having the same blend, was dyed at three different rates and produced in three different raising conditions. The fabrics were woven 100 m in factory conditions and dyed and raised under the same conditions. The selected twill texture is 3/1, 2/1, 2/2, dyeing ratio, 1%, 3%, 5% and raising status-no raising, single passage raising, two passage raising (shearing process is included in all raising). Selected woven fabric performance tests were applied to the fabrics. In the study, 27 fabric samples were used for the Full Factorial Experiment Design and 9 fabric samples were used according to the Taguchi Experiment Design. The results of the performance tests obtained according to both experimental designs were compared. As a result, it has been shown with this study that 9 samples according to the Taguchi method can be used instead of 27 samples according to the full factorial experimental design for optimum results. Experimental design based on Taguchi Method can be used effectively with less experiments in experimental studies where production is very difficult and costly in the field of textile engineering.
Optimization of phosphate oxygen isotope pretreatment measurement method based on phosphate in situ enrichment blanket
Authors: Li Sumei , Du Chengyu , Jin Xin , Yang Jing , Zhang Wei , Li Simin
Published: July 2023

Phosphate oxygen isotope analysis is an effective tool for investigating phosphorus migration and transformation in water bodies. Unfortunately, current pretreatment methods for this technology are significantly limited due to their demanding sample amount requirements, complex operation, and limited scope of application. In order to enhance the efficiency of the pretreatment process, hydrated zirconia was synthesized through liquid-phase precipitation. Zeolite, D001 macroporous resin, activated carbon, and ceramsite were chosen as possible candidate materials for loading purposes. The optimal zirconium loading material was identified through a combination of field enrichment and laboratory elution experiments. The ideal in situ enrichment duration, material dosages, and elution time were ascertained using response surface methodology. The findings showed that D001 resin exhibited superior selective adsorption and elution capacity for phosphate. The response surface optimization yielded the optimal parameters for the in situ phosphate-enrichment blanket: a mass of 13 g for zirconium-loaded D001 resin, an enrichment period of 360 min, and an elution period of 853 min. The attainment of a bright yellow Ag3PO4 solid after purification served as proof of the reliability of the optimization method. The obtained results provide a fundamental basis for the preparation and application of phosphate oxygen isotope analysis in freshwater ecosystem.
Aducanumab in Alzheimer’s Disease: A Critical Update
Authors: Ashique Sumel , Sirohi Ekta , Kumar Shubneesh , Rihan Mohd , Mishra Neeraj , Bhatt Shvetank , Gautam Rupesh K. , Singh Sachin Kumar , Gupta Gaurav , Chellappan Dinesh Kumar , Dua Kamal
Published: July 2023

:

Alzheimer's disease (AD) is a complex neurological disorder that results in cognitive
decline. The incidence rates of AD have been increasing, particularly among individuals
60 years of age or older. In June 2021, the US FDA approved aducanumab, the first humanized
monoclonal antibody, as a potential therapeutic option for AD. Clinical trials have shown
this drug to effectively target the accumulation of Aβ (beta-amyloid) plaques in the brain, and
its effectiveness is dependent on the dosage and duration of treatment. Additionally, aducanumab
has been associated with improvements in cognitive function. Biogen, the pharmaceutical
company responsible for developing and marketing aducanumab, has positioned it as
a potential breakthrough for treating cerebral damage in AD. However, the drug has raised
concerns due to its high cost, limitations, and potential side effects. AD is a progressive neurological
condition that affects memory, cognitive function, and behaviour. It significantly impacts
the quality of life of patients and caregivers and strains healthcare systems. Ongoing research
focuses on developing disease-modifying therapies that can halt or slow down AD progression.
The pathogenesis of AD involves various molecular cascades and signaling pathways.
However, the formation of extracellular amyloid plaques is considered a critical mechanism
driving the development and progression of the disease. Aducanumab, as a monoclonal
antibody, has shown promising results in inhibiting amyloid plaque formation, which is the
primary pathological feature of AD. This review explores the signaling pathways and molecular
mechanisms through which aducanumab effectively prevents disease pathogenesis in AD.
The Protective Effect of Sanggenol L Against DMBA-induced Hamster
Buccal Pouch Carcinogenesis Induces Apoptosis and Inhibits Cell
Proliferative Signalling Pathway
Authors: Fu Qing , Zhang Fangming , Vijayalakshmi Annamalai
Published: July 2023

Background:

Oral squamous cell carcinoma (OSCC) has a poor prognosis when treated
with surgery and chemotherapy. Therefore, a new therapy and preventative strategy for OSCC and
its underlying mechanisms are desperately needed. The purpose of this study was to examine the
chemopreventive effects of sanggenol L on oral squamous cell carcinoma (OSCC). The research
focused on molecular signalling pathways in 7,12-dimethylbenz(a)anthracene (DMBA)-induced
hamster buccal pouch (HBP) carcinogenesis.

Aim:

The purpose of this study was to look at the biochemical and chemopreventive effects of
sanggenol L on 7,12-dimethylbenz(a)anthracene (DMBA)-induced HBP (hamster buccal pouch)
carcinogenesis via cell proliferation and the apoptotic pathway.

Methods:

After developing squamous cell carcinoma, oral tumours continued to progress leftward
into the pouch 3 times per week for 10 weeks while being exposed to 0.5 % reactive DMBA three
times per week. Tumour growth was caused by biochemical abnormalities that induced inflammation,
increased cell proliferation, and decreased apoptosis.

Results:

Oral sanggenol L (10 mg/kg bw) supplementation with cancer-induced model DMBApainted
hamsters prevented tumour occurrences, improved biochemistry, inhibited inflammatory
markers, decreased cell proliferation marker expression of tumour necrosis factor-alpha (TNF- α),
nuclear factor (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and
induced apoptosis.

Conclusion:

Sanggenol L could be developed into a new medicine for the treatment of oral carcinogenesis.
Antimicrobial Peptides: Sources, Expression Systems, and Applications
Authors: Li Mengru , Lu Weitao , Sun Yanyan , Dong Chunming
Published: July 2023

Antimicrobial peptides (AMPs) are widely sourced and have a variety of biological activities
such as broad-spectrum antibacterial, antiviral, and anticancer. Since AMPs are less likely
to cause drug resistance, they are expected to be an alternative to antibiotics. Compared with natural
extraction and chemical synthesis methods, producing AMPs using genetic engineering is a hot
research topic for the large-scale production of AMPs. This paper outlines the sources of AMPs, focuses
on different expression systems, and reviews the current status of AMPs applications in animal
husbandry, food preservation and Medicine, and agriculture to provide a theoretical basis and
support for using genetic engineering to express AMPs.
Recent Advancement in Bioactive Chalcone Hybrids as Potential Antimicrobial
Agents in Medicinal Chemistry
Authors: Maurya Anand , Agrawal Alka
Published: July 2023

Chalcones are flavonoid-related aromatic ketones and enones generated from plants. The
chalcones have a wide range of biological activities, such as anti-tumor, calming, and antimicrobial
activities. In the present review, we have focused on the recently published original research articles
on chalcones as a unique antibacterial framework in medicinal chemistry.

:

Chalcones are structurally diverse moieties and can be split into simple and hybrid chalcones, with
both having core pharmacophore 1,3-diaryl-2-propen-1-one. Chalcones are isolated from natural
sources and also synthesized by using various methods. Their structure-activity relationship, mechanisms,
and list of patents are also summarized in this paper. This review article outlines the currently
published antimicrobial chalcone hybrids and suggests that chalcone derivatives may be potential
antimicrobial agents in the future.
QSAR Model based Gradient Boosting Regression of
N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Inhibitors for
Fructose-1,6-bisphosphatase
Authors: Zhao Ziyi , Yang Jialong , Ji Hongxiang , Liu Zeyu , Sun Tingting , NI Tongshang
Published: July 2023

Background:

Due to the complication caused by conventional drugs, global attention has been
focused on the development of novel drugs. As a consequence, a potential theory to put T2DM under
control is of great medical significance.

Methods:

We used the heuristic method to establish the linear model and used Gradient Boosting Regression
to establish the nonlinear model of Fructose-1,6-Bisphosphatse inhibitor successively. In this study,
84 derivatives of N-Arylsulfonyl-Indole-2-Carboxamide were introduced into the models, and two outstanding
QSAR models with 2 molecule descriptors were established successfully.

Results:

Gradient Boosting Regression rendered a good correlation with R2
of 0.943 and MSE of 0.135
for the training set, 0.916 and 0.213 for the test set, which also proves the feasibility of the implementation
of the new method GBR in the field of QSAR. Meanwhile, the optimal model displayed wonderful
statistical significance.

Conclusion:

This study makes an attempt at the application of a new method of GBR in QSAR and
proves GBR as a promising tool for further study of CADD.
Metformin in Type 2 Diabetes: Evidence for its Beneficial Effects on
Frailty and Sarcopenia
Authors: Pyrgioti Elisavet E. , Karakousis Nikolaos D. , Georgakopoulos Petros N. , Papanas Nikolaos
Published: July 2023

This narrative review aimed to discuss the potential interplay among frailty syndrome,
sarcopenia and metformin in type 2 diabetes mellitus (T2DM). There is emerging evidence on the
potential protective role of metformin on both frailty and sarcopenia. However, results are not always
consistent. Thus, further research is needed to provide a definitive answer on any role of metformin
in improving frailty and/or sarcopenia in T2DM.
Development of a New, Fully Validated LC-MS/MS Method for the Analysis
of Flibanserin in Pharmaceutical Preparations and Comparison of the
Chromatographic Performance with Six Stationary Phase Types
Authors: Geven Aysun , Özcan Saniye , Levent Serkan , Can Nafiz Öncü
Published: July 2023

Background:

Initially synthesized as an antidepressant and potentially rapid onset of action,
flibanserin (FLB) was approved by the Food and Drug Administration (FDA) in August 2015 with a
warning to dispense the drug through a dedicated risk management program, despite the removal of
HSDD from the DSM-5TM. The drug is the first noteworthy FDA-approved drug for treating premenopausal
women with acquired, generalized HSDD.

Objective:

In literature, studies are plasma analyses or metabolite determinations to meet pharmacokinetic
analyses and some analytical targets. For this reason, in this thesis, a new method has been developed for
analysing FLB from pharmaceutical preparations, which is our target, providing all optimization conditions
and method validity parameters.

Methods:

The chromatographic separation was also investigated using Chromolith® and Ascentis® Express
models with a total of six stationary phases. The mobile phase mixture was acetonitrile:ammonium
formate (0.020 M, pH 6.0) and was used at the ratio (60:40, v/v). The optimum column temperature was
chosen as 40.0±0.1°C, and the autosampler thermostat temperature was chosen as 15±0.1°C. The sample
injection volume is optimized to be 1 μL.

Results:

The developed method is linear in the range of 2.63–105.0 ng/mL, and the regression coefficient
is 0.999 intraday and 0.986 interday. In the method, LOD and LOQ were obtained as 128 pg/mL and 384
pg/mL, respectively. In addition, the ANOVA P values were calculated as 0.586 and 0.914, respectively,
in the validation studies conducted intraday and interday.

Conclusion:

FLB chromatographic behaviors were studied and compared in detail with six different
stationary phases. The developed method was fully validated according to the ICH Q2 (R1) guideline, and
its pseudo-pharmaceutical formulation was analyzed.
Trojan Microparticles : A Composite Nanoparticle Delivery System
Authors: Shukla Shalu , Pandit Vinay
Published: July 2023

In recent years, microparticulate systems have drawn growing attention as a viable strategy
for delivering cells, proteins, and medications to target areas. The Nanoparticles-in-Microparticles
System (NiMS) is a drug delivery method that combines nano- and microparticles to deliver medications
or genes to particular bodily regions with precision. A promising method for achieving dual or
multiple functions inside a formulation is the development of nanoparticle-in-microparticle systems
(NiMS). NiMS comprises a microparticle (M.P.) matrix and one or more nanoparticles (N.P.s). The
N.P.s can be designed to provide specific functionality, such as targeted drug delivery or imaging,
while the M.P. matrix can be tailored to provide sustained release or protect the N.P.s from degradation.
NiMS offer several advantages over traditional formulations, including the ability to control release
profiles and achieve site-specific delivery. By combining different types of N.P.s and M.P.s, it is
possible to create formulations that release drugs at different rates or with different kinetics, allowing
for tailored treatment regimens. Additionally, by lowering off-target effects and boosting efficacy, the
site-specific targeting offered by NiMS can enhance the therapeutic index of medications. Microparticles
are small, micron-sized particles that can be loaded with therapeutic agents and designed to deliver
them to specific tissues in the body. The pharmaceutical sector is developing microparticulate delivery
systems for oral, pulmonary, and cutaneous administration. For instance, a promising strategy
for treating respiratory conditions, including asthma and chronic obstructive pulmonary disease, is the
development of inhalable microparticles (COPD). Moreover, the use of microparticles for topical drug
delivery is being studied, where they can be formulated into creams, gels, or patches for treating skin
disorders. The composition of microparticles is crucial for successful tissue regeneration because the
particles must be biocompatible and able to interact with the cells in the targeted tissue. In addition,
the size and shape of the particles can affect their behavior and how they interact with cells. Chemical
and biological sensors and devices, optical detectors, electronic components, and nanoscale production
depend on nanostructures because they offer unique properties, such as increased surface area and enhanced
reactivity, which can be exploited to create more efficient and effective devices.
Inappropriate Use of Proton Pump Inhibitor Among Elderly Patients in
British Columbia: What are the Long-term Adverse Events?
Authors: Ben-Eltriki Mohamed , Chhabra Manik , Cassels Alan , Wright James M.
Published: July 2023

Background:

Proton pump inhibitors (PPIs) are one of the most used classes of drugs.
For most indications, PPIs are only recommended up to 8 weeks duration. However, PPI use continues
to expand. Regular and prolonged use of PPIs should be avoided because of the risk of adverse
events.

Objectives:

The main objective of this study was to (1) investigate the extent of PPI usage in
people aged 65 or older in the province of British Columbia (BC), Canada, (2) provide an overview
of the harms associated with the long-term use of PPIs.

Methods:

We examined utilization trends of the PPIs in BC since the year 2009 using PharmaNet,
BC’s medication dispensing database where the information is accessible to community pharmacists.
We performed a comprehensive literature search for relevant reviews reporting harms associated
with long-term use of PPIs. A search was conducted from January 2014 to June 2022.

Results:

Between 2000 and 2018 BC’s population grew by 20%, but the use of PPIs escalated to
257%. Of these older British Columbians, 62% had a cumulative exposure exceeding 2 years and
42% exceeded 5 years. This is alarming because the recommended treatment duration is 4-12
weeks for common indications including reflux esophagitis, and duodenal and gastric ulcers. Only
13.5% were dispensed PPIs for 90 days or less. Patients on long-term PPI therapy should be reassessed.
Adverse events of PPI use are common among older adults. We identified over 217 systematic
reviews published during the last 8 years of specific harms associated with long-term daily
usage of PPIs. These harms include increased risks of death, cardiovascular disease, acute renal injury,
chronic kidney disease, dementia, fractures, hypomagnesemia, iron deficiency, vitamin
B12 deficiency, enteric infection (including C. difficile), pneumonia, and neoplasia (gastric cancer,
carcinoids, and colon cancer), and drug interactions.

Conclusion:

This study revealed a high prevalence of PPI use among elderly populations in BC,
Canada. The overutilization of PPIs is often a result of failure to re-evaluate the need for continuation
of therapy. Published studies identified signals of serious harm from long-term PPI exposure.
Healthcare providers with patients can reverse the relentless expansion of long-term PPI exposure
by discussing the expected benefits and potential harms.
Computational Methods for Functional Characterization of lncRNAS in
Human Diseases: A Focus on Co-Expression Networks
Authors: Jha Prabhash , Barbeiro Miguel , Lupieri Adrien , Aikawa Elena , Uchida Shizuka , Aikawa Masanori
Published: July 2023

Treatment of many human diseases involves small-molecule drugs.Some target proteins,
however, are not druggable with traditional strategies. Innovative RNA-targeted therapeutics may overcome
such a challenge. Long noncoding RNAs (lncRNAs) are transcribed RNAs that do not translate
into proteins. Their ability to interact with DNA, RNA, microRNAs (miRNAs), and proteins makes
them an interesting target for regulating gene expression and signaling pathways.In the past decade, a
catalog of lncRNAs has been studied in several human diseases. One of the challenges with lncRNA
studies include their lack of coding potential, making, it difficult to characterize them in wet-lab experiments
functionally. Several computational tools have thus been designed to characterize functions of
lncRNAs centered around lncRNA interaction with proteins and RNA, especially miRNAs. This review
comprehensively summarizes the methods and tools for lncRNA-RNA interactions and lncRNA-protein
interaction prediction.We discuss the tools related to lncRNA interaction prediction using commonlyused
models: ensemble-based, machine-learning-based, molecular-docking and network-based computational
models. In biology, two or more genes co-expressed tend to have similar functions. Coexpression
network analysis is, therefore, one of the most widely-used methods for understanding the
function of lncRNAs. A major focus of our study is to compile literature related to the functional prediction
of lncRNAs in human diseases using co-expression network analysis. In summary, this article provides
relevant information on the use of appropriate computational tools for the functional characterization
of lncRNAs that help wet-lab researchers design mechanistic and functional experiments.
Insight into the Structure and Physicochemical Properties of Potent
Chemokine Receptor 5 Inhibitors for the Discovery of Novel Alzheimer’s
Disease Drugs
Authors: Mohamed Yusof Nur Intan Saidaah , Awaluddin Nor Atirah , Fauzi Fazlin Mohd
Published: July 2023

Background:

In Alzheimer’s Disease (AD), chemokines recruit pro-inflammatory mediators
and increase the aggregation of both Aβ (amyloid-β) plaque and neurofibrillary tangles
(NFTs). Chemokine receptor 5 (CCR5) has been demonstrated to be involved in neuroinflammation
and neuroimmunology, where its inhibition was shown to enhance memory, plasticity and
learning.

Objective:

In this study, compounds that inhibit CCR5 obtained from the ChEMBL database were
analysed, specifically for whether specific substructures and physicochemical properties are correlated
to biological activity.

Methods:

Clustering was first performed to group 1,237 compounds into 10 clusters based on the
similarities of their structure. Then, molecular docking was performed on 10 compounds representative
of each cluster. Lastly, the Spearman correlation was computed between physicochemical
properties and biological activity.

Results:

Results showed that potent CCR5 inhibitors tend to: (i) be larger in size (molecular
weight of more than 500 g/mol), (ii) bind at the deep hydrophobic pocket, mostly through π-π
stacking and (iii) have more than 1 aromatic ring. The larger size may aid in reaching the deep hydrophobic
pocket. However, these requirements may lead to the violation of more than 1
Lipinski’s Rule of 5.

Conclusion:

Future studies should include analyses of the analogues or derivatives of the representative
compounds to further expand on the findings here and establish the structure-activity relationship
for CCR5 inhibition. This would aid in the development of new AD drugs since drug
discovery and development of AD drugs are suffering from high attrition.
Present Situation and Future Prospects of Motor Cooling System
Authors: Hou Jinting , Xie Baocheng
Published: July 2023

Background:

The motor cooling system is mainly used in aerospace, automotive, and marine fields, where the motor system is cooled to extend the service life and safety of the motor. The running power of motors rises too fast, which leads to the failure of heat dissipation as expected and shortens the service life of motors. Therefore, it is necessary to choose an appropriate cooling mode for motors to improve their cooling structure, reduce their temperature rise, and improve their reliability and service life. The internal motor cooling system can perform fixed-point heat dissipation, but the overall heat dissipation is poor. The external motor cooling system can perform overall heat dissipation but has high requirements on the structure. Over the years, the application and development of motor cooling systems have gained more and more attention.

Objective:

This paper discusses the structural characteristics, advantages, and development trends of the motor cooling system in order to reduce the temperature rise of the motor and improve its reliability and service life. This paper aims to provide an overview and systematic guidance for future designs of the motor cooling system.

Methods:

According to the structural characteristics of the motor cooling system and the requirements of the motor application field, the most typical internal cooling system and external cooling system in the motor cooling system are summarized.

Results:

By analyzing the causes and hazards of motor heating, the limited requirements of the motor system in use are summarized. The motor system is classified and compared based on the structure, heat dissipation principle, and use of the motor heat dissipation system. The characteristics of small volume and strong heat dissipation ability are also summarized. Based on the analysis of the internal and external cooling system, the problems of complex structure and poor cooling effect are summarized, and the future development trend and direction of the motor cooling system are discussed in detail.

Conclusion:

This paper divides the motor cooling system into an internal cooling system and an external cooling system according to the specifications and operating environment. This paper expounds on internal and external cooling systems' different principles, advantages, and disadvantages. This paper summarizes the cooling systems in recent years in order to facilitate their subsequent development and use. The main components of additional patents for future inventions are motor cooling systems, innovation in structure simplification, and cost performance optimization.
Review of Patents Analysis on Floor Robot Vacuum
Authors: Jianying Li , Yaqian Wang , Yuru Zhou , Aokun Wei
Published: July 2023

Background:

As the pace of life gets faster, and with the development and progress of society and the continuous improvement of people's pursuit of a convenient and comfortable life, it has become a growing desire for people to get rid of tedious housework. Hygienic automatic cleaning has also become the main demand of people.

Objective:

Through review, analysis, and discussion of the patents on existing floor robot vacuums, it is expected to find out the development process and main outcomes, along with the main technologies involved, and provide a valuable prediction basis for future research and development directions.

Methods:

This study aimed to summarize a number of representative patents related to floor robot vacuums and their main components and analyze them in depth to study their technical points and development laws.

Results:

By summarizing a large number of patents on floor robot vacuums and further analyzing and comparing the characteristics of the patents, the future development trend of floor robot vacuums was further discussed.

Conclusion:

Through a detailed analysis of the mechanical structure, intelligent control technology, and sensor technology of the existing floor robot vacuums as a whole and the main work unit, this study discussed the ideas and methods of improving the new floor robot vacuum, which is of great significance to its operation and more convenient and intelligent.
Hand-in-glove Effect of Piperine in Anti-cancer Formulations
Authors: Kumar Jatin , Kriplani Priyanka , Guarve Kumar
Published: July 2023

Background:

Piperine, an active constituent isolated from Piper nigrum, Piper chaba, Piper sarmentosum, Piper guineense and Piper longum which is used to cure a variety of ailments related to lung, stomach, colon, skin etc. like Alzheimer’s, Parkinson’s disease, ulcerative colitis, cancer, arthritis, inflammatory bowel diseases, diabetes etc.

Objective:

The objective of the review is to study the synergistic effect of piperine specially in cancer.

Methods:

Patents and current literature mainly emphasizing the synergistic effect of piperine along with other drugs, especially anticancer drugs was reviewed keeping in mind the scientific novelty and impact.

Results:

Several synergistic combinations of piperine were explored which can be beneficial for the pharmaceutical industry.

Conclusion:

This review will assist the researchers in the preparation of novel formulations with improved efficacy cutting the cost of developing new drug molecules.
La pandemia como aprendizaje intercultural. La perspectiva de la filosofía andina
Authors: Estermann Josef
Published: July 2023

El presente trabajo plantea la actual pandemia del Covid-19 como un desafío intercultural al modelo civilizatorio occidental moderno. Se parte de la hipótesis de que la crisis sanitaria es solo un síntoma de una crisis sistémica civilizacional que engloba aspectos económicos, políticos, ecológicos, éticos y axiológicos. El fondo de esta megacrisis radica en el descarrilamiento de una modernidad basada en los axiomas del crecimiento, progreso y el afán individualista de lucro. La cosmoespiritualidad o filosofía andina plantea una visión holística de las múltiples crisis y nos enfrenta con la figura del pachakuti, el cambio brusco e inevitable del modo de pensar y del actual sistema global.
Penguatan pendidikan karakter berbasis kearifan lokal Mandar Metabe’ dan Mepuang di SDN 001 Campalagian
Authors: Hartiwisidi Nurcahya , Damayanti Eka , Musdalifah Musdalifah , Rahman Ulfiani , Suarga Suarga , Shabir U M
Published: July 2023

This study aims to strengthen character education based on the local wisdom of Mandar Metabe' and Mepuang at State Elementary School 001 Campalagian Polewali Mandar, West Sulawesi. Researchers try to examine more deeply the management of programs that have been made starting from planning, implementation, and evaluation. This research is a qualitative descriptive study with an ethnographic approach and was compiled using primary and secondary data. In this study, researchers used the concept of local wisdom of Mandar culture and character education strengthening programs in linking existing theories and facts. Through this research it can be seen that there are four programs of character education strengthening compiled by SDN 001 Campalagian which are carried out through learning methods and routine activities (habituation), namely (1) one day speaking Mandarin, (2) greeting the teacher with the nickname Puang as a form of habituation of respecting elders, (3) integration of local wisdom material which is carried out during the learning process by inserting local wisdom material such as the virtues of Metabe' and Mepuang, and (4) ibda' bi nafsika which means starting from oneself which is done by giving examples of commendable behavior from the teacher towards students.
Upaya menumbuhkan karakter gemar membaca melalui gerakan literasi nasional
Authors: Dewi Amelia
Published: July 2023

Reading is a useful activity to add information, knowledge, and insight. If from an early age the children are trained and accustomed to reading, than the character of liking to read will grow in the children. All components of society can participate to increase the communitiy’s literacy index by cultivating the character of liking to read. The purpose of this research is to identify various efforts that can be made to foster the character of liking to read in Indonesian society. The research method used is library research. The main data source used in this research is a collection of previous research journal articles and books that are relevant to the research discussion. The results of the research show that the literacy index of Indonesian people is still quite lacking, efforts that can be made to improve the literacy index can be through learning, exemplary, strengthening, and habituation. In addition, parents or teachers can use the storytelling method in order to attract children's attention and interest to read. These efforts can be done as early as possible in order to grow into a strong characters and not be carried away by the swift currents of technology and globalization.
Penanaman karakter disiplin dan tanggung jawab melalui penegakan tata tertib sekolah di SMK Negeri 1 Gesi
Authors: Utomo Randi Seno Yudho , Setyadi Yulianto Bambang
Published: July 2023

This study aims to describe the cultivation of the character of discipline and responsibility through enforcing school rules, as well as the inhibiting factors, driving factors, and the role of parents in instilling these characters at SMK Negeri 1 Gesi, Sragen Regency. This is qualitative descriptive research with a case study design. Collecting data using observation, interviews, and documentation techniques. Data analysis used the interactive analysis technique of the model of Miles and Huberman. The results showed that the cultivation of the character of discipline and responsibility at SMK Negeri 1 Gesi was carried out by getting into the habit of arriving on time, wearing complete and neat uniforms, obeying regulations, carrying out picket duties regularly, guarding and maintaining educational facilities, and participating in school activities. Inhibiting factors include road access and obstacles to vehicles, lack of attention from parents, influence of other students, as well as being lazy and arriving late on purpose. The driving factors include sanctions, monitoring and implementation of inspections, the existence of student pocket books, and the attention of teachers and fellow picket groups to create a clean and comfortable learning atmosphere. The role of parents includes getting used to time discipline, setting an example of ethical dress, and getting used to obeying rules.
Hubungan pembinaan agama orang tua dengan disiplin belajar siswa
Authors: Muhayanah Muhayanah , Habudin Habudin , Juhji Juhji
Published: July 2023

Disiplin merupakan hal yang sangat dibutuhkan dalam pembelajaran. Siswa yang berkarakter disiplin akan bersungguh-sungguh dalam belajar. Penelitian ini bertujuan mendeskripsikan pembinaan keagamaan orang tua, mendeskripsikan disiplin belajar siswa, dan menganalisis hubungan pembinaan keagamaan orang tua dengan disiplin belajar siswa. Penelitian ini dilakukan di Sekolah Dasar Negeri Unyur Kota Serang dengan populasi sebanyak 289 siswa dan sampel sebanyak 43 siswa yang tersebar di kelas 4, 5, dan 6. Penelitian ini menggunakan pendekatan kuantitatif korelasional yaitu mencari hubungan antara variabel independen dan variabel dependen. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu observasi, wawancara, dan angket. Simpulan yang didapat dari hasil penelitian ini yaitu: berdasarkan analisis korelasi Product Moment diperoleh nilai korelasi sebesar 0,98. Hal ini menunjukkan bahwa antara pembinaan keagamaan orang tua dan disiplin belajar siswa memiliki korelasi yang sangat tinggi. Pembinaan keagamaan orang tua memberikan kontribusi yang cukup besar terhadap disiplin belajar siswa kelas tinggi SD Negeri Unyur Kota Serang dengan nilai koefisien determinasi sebesar 0,96 atau 96%, dengan sisanya dipengaruhi oleh variabel lain yang dapat diteliti kembali.Discipline is something that is needed in learning. Students with disciplined character will be serious in learning. This study aims to describe the religious formation of parents, to describe the discipline of student learning, and to analyze the relationship between the religious formation of parents and the discipline of student learning. This research was conducted at State Elementary School (SD Negeri) Unyur, Serang City with a population of 289 students and a sample of 43 students spread across grades 4, 5, and 6. The research uses used a correlation quantitative approach, namely looking for the relationship between the independent variable and the dependent variable. Data collection techniques used in this study are observation, interviews, and questionnaires. The conclusions obtained from the results of this study are based on the product moment correlation analysis, the correlation value is 0.98. This shows that there is a very high correlation between religious guidance of parent and student learning discipline. The religious guidance of parents contributes significantly to the learning discipline of high-class students at SD Negeri Unyur, Serang City with a coefficient of determination of 0.96 or 96%, with the rest being influenced by other variables that can be re-examined.
Development and Testing of a Data Capture Device for Use With Clinical Incentive Spirometers: Testing and Usability Study
Authors: Burns Michael L , Sinha Anik , Hoffmann Alexander , Wu Zewen , Medina Inchauste Tomas , Retsky Aaron , Chesney David , Kheterpal Sachin , Shah Nirav
Published: July 2023

Background

The incentive spirometer is a basic and common medical device from which electronic health care data cannot be directly collected. As a result, despite numerous studies investigating clinical use, there remains little consensus on optimal device use and sparse evidence supporting its intended benefits such as prevention of postoperative respiratory complications.

Objective

The aim of the study is to develop and test an add-on hardware device for data capture of the incentive spirometer.

Methods

An add-on device was designed, built, and tested using reflective optical sensors to identify the real-time location of the volume piston and flow bobbin of a common incentive spirometer. Investigators manually tested sensor level accuracies and triggering range calibrations using a digital flowmeter. A valid breath classification algorithm was created and tested to determine valid from invalid breath attempts. To assess real-time use, a video game was developed using the incentive spirometer and add-on device as a controller using the Apple iPad.

Results

In user testing, sensor locations were captured at an accuracy of 99% (SD 1.4%) for volume and 100% accuracy for flow. Median and average volumes were within 7.5% (SD 6%) of target volume sensor levels, and maximum sensor triggering values seldom exceeded intended sensor levels, showing a good correlation to placement on 2 similar but distinct incentive spirometer designs. The breath classification algorithm displayed a 100% sensitivity and a 99% specificity on user testing, and the device operated as a video game controller in real time without noticeable interference or delay.

Conclusions

An effective and reusable add-on device for the incentive spirometer was created to allow the collection of previously inaccessible incentive spirometer data and demonstrate Internet-of-Things use on a common hospital device. This design showed high sensor accuracies and the ability to use data in real-time applications, showing promise in the ability to capture currently inaccessible clinical data. Further use of this device could facilitate improved research into the incentive spirometer to improve adoption, incentivize adherence, and investigate the clinical effectiveness to help guide clinical care.
Leveling the Research Playing Field: Decolonizing Global Health Research Through Web-Based Platforms
Authors: Seth Rajeev , Dhaliwal Baldeep K , Miller Emily , Best Tyler , Sullivan Alexis , Thankachen Betty , Qaiyum Yawar , Shet Anita
Published: July 2023

Global health research has traditionally been rooted in colonialism, with some investigators in high-income countries leading and managing research and investigators in low- and middle-income countries serving as implementing partners. The Community Health Worker-Led Intervention for Vaccine Information and Confidence (CIVIC) Project, conducted in India and led jointly by India- and US-based investigators, leveraged web-based platforms to facilitate a more horizontal, inclusive, and balanced approach to partnerships between researchers and the community. Using web-based platforms to conduct research was found to be an effective strategy to engage researchers at all levels and combat systemic barriers associated with in-person activities such as power, economic, social, and gender dynamics. Connecting online for research meetings created a more equitable environment for community members to engage meaningfully with research. Further, by conducting research through web-based platforms, we found that we were able to strengthen the diversity of participants, provide a space for more marginalized groups to speak up, and minimize logistical barriers to attendance. Harnessing web-based approaches in research provides a pathway toward opportunities to promote equity and contribute to the decolonization of global health spaces.
Increased Access, Persistent Disparities
Authors: Knapp Christopher D. , Li Shuling , Kou Chuanyu , Gilbertson David T. , Weinhandl Eric D. , Wetmore James B. , Hart Allyson , Johansen Kirsten L.
Published: July 2023

Peritoneal dialysis (PD) use has increased in the United States since 2009, but how this has affected disparities in PD use is unclear. We used data from the United States Renal Data System to identify a cohort of incident dialysis patients from 2009 to 2019. We used logistic regression models to examine how odds of PD use changed by demographic characteristics. The incident PD population increased by 203% from 2009 to 2019, and the odds of PD use increased in every subgroup. PD use increased more among older people because the odds for those aged 75 years or older increased 15% more per 5-year period compared with individuals aged 18–44 years (odds ratio [OR] 1.68, 95% confidence interval [CI], 1.64 to 1.73 versus OR 1.46, 95% CI, 1.42 to 1.50). The odds of PD use increased 5% more per 5-year period among Hispanic people compared with White people (OR 1.58, 95% CI, 1.53 to 1.63 versus OR 1.51, 95% CI, 1.48 to 1.53). There was no difference in odds of PD initiation among people who were Black, Asian, or of another race. The odds of PD use increased 5% more for people living in urban areas compared with people living in nonurban areas (5-year OR 1.54, 95% CI, 1.52 to 1.56 versus 5-year OR 1.46, 95% CI, 1.42 to 1.50). The odds of PD use increased 7% more for people living in socioeconomically advantaged areas compared with people living in more deprived areas (5-year OR 1.60, 95% CI, 1.56 to 1.63 for neighborhoods with lowest Social Deprivation Index versus 5-year OR 1.50, 95% CI, 1.48 to 1.53 in the most deprived areas). Expansion of PD use led to a reduction in disparities for older people and for Hispanic people. Although PD use increased across all strata of socioeconomic deprivation, the gap in PD use between people living in the least deprived areas and those living in the most deprived areas widened.
Stakeholder Perspectives on Factors Related to Deprescribing Potentially Inappropriate Medications in Older Adults Receiving Dialysis
Authors: Hall Rasheeda K. , Rutledge Jeanette , Lucas Anika , Liu Christine K. , Clair Russell Jennifer St. , Peter Wendy St. , Fish Laura J. , Colón-Emeric Cathleen
Published: July 2023

Background

Potentially inappropriate medications, or medications that generally carry more risk of harm than benefit in older adults, are commonly prescribed to older adults receiving dialysis. Deprescribing, a systematic approach to reducing or stopping a medication, is a potential solution to limit potentially inappropriate medications use. Our objective was to identify clinicians and patient perspectives on factors related to deprescribing to inform design of a deprescribing program for dialysis clinics.

Methods

We conducted rapid qualitative analysis of semistructured interviews and focus groups with clinicians (dialysis clinicians, primary care providers, and pharmacists) and patients (adults receiving hemodialysis aged 65 years or older and those aged 55–64 years who were prefrail or frail) from March 2019 to December 2020.

Results

We interviewed 76 participants (53 clinicians [eight focus groups and 11 interviews] and 23 patients). Among clinicians, 24 worked in dialysis clinics, 18 worked in primary care, and 11 were pharmacists. Among patients, 13 (56%) were aged 65 years or older, 14 (61%) were Black race, and 16 (70%) reported taking at least one potentially inappropriate medication. We identified four themes (and corresponding subthemes) of contextual factors related to deprescribing potentially inappropriate medications: (1) system-level barriers to deprescribing (limited electronic medical record interoperability, time constraints and competing priorities), (2) undefined comanagement among clinicians (unclear role delineation, clinician caution about prescriber boundaries), (3) limited knowledge about potentially inappropriate medications (knowledge limitations among clinicians and patients), and (4) patients prioritize symptom control over potential harm (clinicians expect resistance to deprescribing, patient weigh risks and benefits).

Conclusions

Challenges to integration of deprescribing into dialysis clinics included siloed health systems, time constraints, comanagement behaviors, and clinician and patient knowledge and attitudes toward deprescribing.
The Construction of “Curriculum Ideology and Politic” in Finance and Law Courses under the Theory of Embodied Cognition
Authors: Li Yuren
Published: July 2023

Financial and legal courses play a key role in the professionalism of financial students, but the “Curriculum Ideology and Politic” in this course area is facing problems such as the deviation of the subject and the content, the alienation of the course and the profession, and the disconnection between moral education and intellectual education. and intellectual education. An effective solution is to introduce the theory of embodied cognition, which emphasises students’ practice, experience and participation, and can effectively reconcile the contradiction between knowledge transmission and value shaping to ensure their consistency. Under the guidance of the concept of embodied cognition, the construction of “Curriculum Ideology and Politic” in combination with specific courses has proved its value in enhancing students’ participation and emotional resonance, and realised the same direction of knowledge transmission, ability shaping and value guidance. However, different “embodied” teaching behaviours still have limitations, and teachers still need to choose appropriate methods according to the teaching content and students’ characteristics. Looking ahead, the reform of Curriculum Ideology and Politic under the perspective of embodied cognition should pay more attention to the importance of teachers’ “teaching by words and example”, balance the relationship between human beings and technology, and ensure the effectiveness of Curriculum Ideology and Politic.
Investigating the Impact of Computer-Assisted Language Learning (CALL) on English as a Second Language (ESL) Instruction in the Classroom
Authors: Shanmugam Kalaiyarasi , Jeevarathinam S. N. , Saravanan B.
Published: July 2023

This research study aimed to investigate the impact of Computer Assisted Language Learning (CALL) on English as a Second Language (ESL) instruction in the classroom. The integration of CALL had gained increasing attention in language learning due to its potential to enhance instructional practices and learner outcomes. However, empirical research was needed to examine the specific effects of CALL in the ESL context. The study began with a comprehensive literature review to identify gaps and areas requiring further investigation. Specific research questions were formulated to address these gaps. The research design was determined based on the objectives, utilizing an appropriate methodology such as experimental, quasi-experimental, or mixed methods design. Participants consisted of ESL learners from a specific age group or proficiency level, and a suitable sample size and sampling method were determined. Data collection involved various methods such as surveys, observations, interviews, and pre/post-tests to gather comprehensive data. Ethical considerations were addressed, ensuring informed consent and data privacy. The collected data were analyzed using appropriate statistical or qualitative analysis techniques. The results were interpreted to answer the research questions and contribute to the understanding of the impact of CALL on ESL instruction. Visual representations, such as charts and graphs, were included to enhance the presentation of results. The discussion and conclusion provided an interpretation of the findings and their implications for ESL instruction and the integration of CALL. Comparisons with previous research were made, and the limitations of the study were acknowledged. Recommendations for ESL teachers, curriculum developers, and policymakers were provided based on the study's findings. Finally, suggestions for future research were presented to further explore the potential of CALL in the ESL classroom. The research study aimed to contribute to the field of language learning and provide insights that could inform pedagogical practices and instructional design.