bluuebunny/crossref_metadata_2025 huggingface dataset:
Combining Photothermal Therapy with A NanohybridBased Drug Delivery Strategy for Slow-Released Doxorubicin: A Treatment for Hepatocellular Carcinoma
Authors: Habiburrahman Muhammad , Putra Afid Brilliana , Rakasiwi Muhammad Ilham Dhiya
Published: June 2023

Background: Hepatocellular carcinoma (HCC) is the fifth most common malignancy in the world. Surgical intervention remains the primary treatment option for resectable liver cancer. However, the low curative resection ratio, high metastatic ratio, and risk of recurrence make this treatment less than ideal. Additionally, the choice of liver transplantation is limited by the availability of donors. This literature review aimed to discuss the combination strategy of photothermal therapy and nanohybrid-based chemotherapy delivery, which are expected to address the challenges in HCC treatment. Methods: We conducted literature searches in Pubmed, Scopus, ProQuest, and Google Scholar using combined keywords such as “hepatocellular carcinoma”, “polyethylene glycol”, “doxorubicin”, “mesoporous silica”, “CuS”, “nanoparticle”, and “photothermal therapy”. Based on the assessment of validity and applicability aspects using modified Oxford CEBM (Center for Evidence-Based Management) and OHAT (Office of Health Assessment and Translation) checklist tools for preclinical studies, all the selected studies fulfilled the eligibility criteria. Results: Photothermal therapy promotes necrosis and apoptosis of HCC cells by ‘heating’ the cancer cells. Meanwhile, the chemotherapy agent doxorubicin, modified with mesoporous silica nanohybrids and encapsulated copper sulfate polyethylene glycol (PEG-DOX-MSN-CuS), enhances the efficiency and duration of drug circulation in the blood, reduces drug clearance, and minimizes retention by the reticuloendothelial system. By utilizing near-infrared light induction from photothermal therapy, doxorubicin can be slowly released, leading to significantly improved effectiveness. In vitro studies have demonstrated that this this combination strategy achieves over 90% HCC cell death at a chemotherapy concentration of 80 µg/mL, in conjunction with near-infrared light induction. The optimal release time for doxorubicin was recored at a concise 20 minutes. Conclusions: Given the numerous benefits associated with this combination of strategies, photothermal therapy using PEG-DOX-MSN-CuS holds significant expected to be a promising treatment for HCC.
Kınalızâde Ali Çelebi’nin Fıkıh Eserlerinin Tespiti
Authors: ORAZOV Orazsahet
Published: June 2023

Kınalızâde Ali Çelebi (ö. 979/1572), birçok medresede müderrislik yapmış, dönemin farklı yönetim merkezlerinde kadılık görevlerini icra etmiş Osmanlı Devleti’nin seçkin ilim adamlarından biridir. Kendisi tefsir, kelam, tasavvuf, ahlak, tarih, dil ve edebiyat alanlarında eserler miras bırakmış ve ilme katkı sağlamış çok yönlü bir âlimdir. Görüldüğü kadarıyla Kınalızâde’nin yayımlanmış olan meşhur eseri Ahlâk-ı Alâî bağlamında önemli çalışmalar yapılarak ahlakla ilgili görüşleri ortaya konulmuşken, diğer eser verdiği alanların çoğunda kaleme almış olduğu eserler ve görüşleri kısmen incelendiğinden yeteri kadar gündeme getirilmemiştir. Bu bağlamda Kınalızâde’nin araştırılması gereken yönlerinden birisi de fakîhliği ve yazdığı fıkıh eserlerinin tespitidir. Kınalızâde’nin fıkıh eserleri incelendiğinde tabakât, mesâil (ıstılâhât-ı mütedâvile) ve fürû fıkıh konularında eserler kaleme aldığı görülmektedir. Onun tabakât eseri, Hanefî fakihlerin ictihad-taklit dereceleri ve teliflerini değerlendirdiği risâleleri incelenerek yayımlanmıştır. Kendisinin Risâle fi’l-gasb adlı küçük hacimli eseri ve vakfın “istibdâl ve isti’câr” konularını ele aldığı risâlesinin “istibdâl” kısmı da tahkik edilerek neşredilmiştir. Ancak günümüze ulaşmış olan diğer fıkıh çalışmaları ise yazma halinde olup, henüz bir ilmi çalışmaya konu olmamıştır. Yayımlanmamış fıkhî eserleri özelinde belirtmek gerekirse kaynaklarda ve kütüphane kayıtlarında birkaç eserinin birden fazla isimle adlandırılmaları veya bazısının yanlış adlandırılması söz konusudur. Bu çalışmada bir yandan Kınalızâde’nin fıkıh eserleri ve kendisine aidiyeti tespit edilmeye çalışılırken, diğer yandan da eserlerin içerikleri hakkında genel mahiyetli bilgiler sunulmaya çalışılacaktır. Bu ise ileride Kınalızâde’nin yazma halinde olan eserlerinin tahlil edilerek tahkikli neşrinin hazırlanmasına ve böylece metin olarak fıkıh müellefatı arasında yer almasına, ayrıca kendisinin fıkhî vasfının ve konumunun gün yüzüne çıkmasına vesile olması bakımından önemlidir.
A Study of John Burton’s Theory on the Origins of the Hadīth
Authors: TEKİN Dilek
Published: June 2023

Western scholars have been interested in the origins and historical reliability of ḥadīth literature since roughly the third quarter of the XIX. century. There have been scholars whose works stand out because of their significance for further Hadīth scholarship and originality. They all claimed crucial problems regarding the origins and transmission of Hadīth and its literature, then struggled to solve them through the modern methods of literary and historical criticism. In this context, John Burton’s (d. 2014) work seems to be highly influenced by his predecessors. Yet, his idea about the role of the Qur’ān in the development of Hadīth literature has still been considered original. Hence, Burton could be considered one of the authors whose ideas on Hadīth scholarship have proven to be influential enough to raise discussions. Burton’s views on the Qur’ān and its history have been studied from different angles by Turkish researchers. But little is known about his theses on the Hadīth literature. This article will focus on how his theory and method on the Qur’ān manuscripts shaped his arguments in An Introduction to the Hadīth. First, there will be a brief introduction to John Burton’s intellectual biography followed by an examination of his main theses regarding the classical Hadīth scholarship. Second, an evaluation and summary of Burton’s ideas on the origins of Hadīth will be presented. Finally, his conclusions will be compared with the views of prominent Western Hadīth scholars such as Ignaz Goldziher (d. 1921) and Joseph Schacht (d. 1969) and will be reviewed from the Islamic perspective.
DETERMINAN SHARE RETURN PADA INDUSTRIAL GOODS CONSUMP-TION SECTOR
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Margaret Angeline , Martono Cyrillius ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Memarista Gesti ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: June 2023

The paper determined the effect of the exchange rate, inflation, and interest rate on the go-public share return. The researchers used the industrial goods consumption sector during 2019-2021 as the sample. There were three independent variables for this study such as the exchange rate, inflation, and interest rate. In addition, the dependent variable was share return. Multiple regression was used to run the parameter. The research used 133 go public companies during those 3 years. According to the research results of this paper, the inflation variable was excluded since the data remain the same for all samples during the research period. The research result showed that the exchange rate has no significant effect on share returns, yet the interest rates variable has a significant positive effect on share returns. So, thus if the value of interest rates in the country is increasing, the share returns in the industrial goods consumption sector will also increase.
ANALISIS PENGARUH BRAND ATTITUDE DAN BRAND QUALITY TERHADAP BRAND VALUE DAN BRAND LOYALTY PADA SMARTPHONE SAMSUNG DI SURABAYA
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Rizaldy Julio Immanuel , Kristanti Maria Mia ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Setyawan Annisa Alfa ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: June 2023

The purpose of the research was to determine the effect of Brand Attitude, Brand Quality on Brand Value and Brand Loyalty on Samsung smartphone products. The research was conducted using a quantitative approach with the number of samples analyzed, namely 150 Samsung smartphone users in Surabaya. Data collection techniques were carried out using questionnaires and partial least squares analysis as data analysis techniques. The results showed that 1) Brand Attitude has a significant effect on Brand Value, 2) Brand Attitude has a significant effect on Brand Loyalty, 3) Brand Quality has a significant effect on Brand Value, 4) Brand Quality has a significant effect on Brand Loyalty, and 5) Brand Value has a significant effect significantly significant to Brand Loyalty.
PENGARUH GREEN PRODUCT INNOVATION DAN GREEN MARKETING TERHADAP BRAND IMAGE DALAM PURCHASE DECISION PRODUK AVOSKIN PADA KONSUMEN DI SURABAYA
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Putri Theresia Andrea Nauvalin Rinaldi , Lindawati Tuty ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Handayani Yuliasti Ika ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: June 2023

The increased interest in using skincare has resulted in an increase in consumer skincare waste that is consumable and cannot be recycled as a whole. Therefore, this study aims to analyze and test the effect of green product innovation and green marketing on brand image in the purchase decision of Avoskin products for consumers in Surabaya. Data collection was for 160 respondents located in Surabaya, the data collection tool used in this study was distributing questionnaires via Google Form using the Non-Probability Sampling method with the Purposive Sampling technique. Analysis techniques and hypothesis testing using SEM with the SmartPLS3 program. The results of this study indicate that green product innovation has a positive and significant effect on brand image but does not have a significant effect on purchase decision. In addition, green marketing has a positive and significant effect on brand image and purchase decision.
PENGARUH BUDAYA ORGANISASI ETIS TERHADAP ORGANIZA-TIONAL CITIZENSHIP BEHAVIOR (OCB) DENGAN KOMUNIKASI TRANSPARAN SEBAGAI VARIABEL INTERVENING PADA PERUS-AHAAN PERBANKAN DI KABUPATEN GRESIK
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Putri Virginia Gading Utomo , Runtu Julius ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Nagel Julius F ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: June 2023

Digitalization has affected all aspects of business including the banking business. Digitalization has increased efficiency in work, especially regarding the need for human resources. Digitalization has reduced the quantity of human resources needed thereby increasing the demand for quality employees. One of the required employee characteristics is high organizational citizenship behavior (OCB). This study analyzes the influence of ethical organizational culture on OCB with transparent communication as an intervening variable in banking companies in Gresik district. Data were collected from 160 respondents using a non-probability sampling technique using purposive sampling. SEM-PLS is used in the analysis of research data. The research results obtained are hypotheses 1 and 2 are accepted, while hypotheses 3 and 4 are rejected. The results also show that ethical organizational culture has a positive and significant effect on transparent communication, ethical organizational culture has a positive and significant effect on organizational citizenship behavior, transparent communication has a positive but not significant effect on organizational citizenship behavior, and transparent communication has no mediating effect on organizational culture. ethical on organizational citizenship behavior.
Detection of foray behaviour in zooplankton of the Antarctic Polar Front region
Authors: Dewar-Fowler V , Robinson C , Saunders RA , Tarling GA
Published: June 2023

In addition to diel vertical migration, individual zooplankton may also make a number of shorter-term migrations, or forays, into the surface layers from deeper depths. Direct observation of these forays is limited, particularly in the open ocean, which hinders our understanding of carbon flux via the biological carbon pump (BCP). We designed a novel net device capable of trapping zooplankton during such forays. The motion-compensated upward and downward looking (MUDL) net device consisted of 2 conical nets, one looking upwards and the other looking downwards, designed for stationary deployment at a set depth, into which migrating individuals must swim to be captured. The device was deployed at different time points within the diel cycle and at contrasting environments across the Antarctic Polar Front region in the southwestern Atlantic sector of the Southern Ocean. A range of zooplankton species were captured, with differences in abundance and species composition between times of day, net directions and sites. Of particular note was the large contribution of the copepod Oithona spp. to catches of both the upward and downward looking nets. Our study demonstrates the utility of our MUDL net for future ecosystem studies in the open ocean, particularly in relation to quantifying vertical carbon flux via the BCP.
Üniversite Şehri Kriterleri: Eskişehir Örneği
Authors: ATEŞ Deniz , TUNÇEL Harun
Published: June 2023

Şehirlerin sınıflandırılması için birtakım ölçütlere gerek duyulmaktadır. Bu ölçütler değişken olmakla birlikte asıl amacı şehirlerin arazi kullanımındaki farklılaşmayı ve birbirleri ile olan ilişkilerini anlamaktır. Günümüzde şehirlerin tanımlanması için yaygın olarak kullanılan ölçütler idari sınırlar, nüfus ve ekonomik faaliyetlerdir. Bu çalışmada üç devlet üniversitesi bulunan Eskişehir’in, uzun yıllardır sözü edilen “üniversite şehri” kimliği sorgulanmıştır. Üniversite şehri fonksiyonunu tanımlamak için; literatür taraması, toplanan veriler ve arazi çalışmaları sonucunda, “beşeri unsurlar ve mekânsal göstergeler” olarak iki ana kriter ve alt kriterler oluşturulmuştur. Beşeri unsurlar; üniversiteye kayıtlı öğrenci nüfusu, ulaşım özellikleri, mal ve hizmete erişim, barınma, yerel yönetimlerin desteği, istihdam, sosyo-kültürel imkânlardır. Mekânsal göstergelerde ise şehir içindeki farklı amaçlar için kullanılan alanlar dikkate alınarak Üniversite Caddesi’ndeki işletmeler değerlendirilmiştir. Ayrıca Eskişehir’de kentsel mekân kullanımına ilişkin öğrenci, yerel halk ve ortak alan olmak üzere üç ana alışveriş alanı belirlenmiştir. Son olarak Covid-19 döneminde üniversitelerin uzaktan eğitime geçmesi ve bunun şehirde görülen etkileri tartışılmıştır.
Sağlık Bilgi Yönetimi Perspektifinden Tıbbi Dokümantasyon ve Sekreterlik: Tarihi Bir İnceleme
Authors: SENEL TEKİN Perihan
Published: June 2023

Bu makalede, tıbbi kayıtların işlenmesi ile ilgili tarihi ve gelişimsel süreç konu edilmektedir. Bu gelişim sağlık bilgi yönetimi bakışı ile Tıbbi Dokümantasyon ve Sekreterlik-TDS mesleği çerçevesinde incelenmektedir. Sağlık hizmetlerinin etkin, kaliteli ve verimli bir şekilde sunulması ile ilgili olan bu alan, yaklaşık bir asırlık geçmişe rağmen alan yazında yeterince ilgi görmemiştir. Tıbbi belgelerin tarihi, mağara çizimlerinde, kil tabletlerde, Mısır, Yunanistan ve Çin gibi eski uygarlıklara kadar papirüs parşömenlerinde bulunan tıbbi kayıtların ilk örnekleriyle eski zamanlara kadar uzanmaktadır. Bu tarihi süreç Hipokrat, Galen, Razi ve İbn-i Sina gibi ünlü hekimlerin katkıları ile şekillenmiştir. Hastanelerin sağlık merkezi olarak gelişmesi ve elektronik sağlık kayıtlarının kullanılması, AHIMA gibi mesleki kuruluşların etkisi ile bugün tıbbi kayıt yönetimi alanı önemli bir noktaya gelmiştir. Ülkemizde tıbbi kayıtlar ile ilgili meslek olan TDS eğitim ve çalışma standartları yüksek ve hızla gelişen bir uzmanlık alanıdır. TDS uzmanları, tıbbi ve idari kayıtların uluslararası standartlara ve yasal gerekliliklere bağlı kalarak düzenlenmesi ve arşivlenmesinden sorumludur. TDS profesyonelleri, görevlerini etkili bir şekilde yerine getirmek için gerekli bilgi ve becerilere sahip olmalıdır.
Pengembangan Sumber Daya Manusia Melalui Pengenalan Konsep DISC pada Remaja Panti Asuhan Putra Setia Yayasan Rukun Istri Sejahtera, Jakarta Pusat
Authors: Basudani Wahid Akbar , Abdullah Muhammad , Zuniarti Ida , Simamora Valentine Theresia
Published: June 2023

This Community Service activity aims to provide socialization and training for teenagers who are under the guidance of the Putra Setia Orphanage, the Rukun Istri Sejahtera Foundation, Central Jakarta where these teenagers need knowledge about personality development with the DISC concept. The method used is to give lectures or direct presentation of material. The DISC concept consists of Dominant, Influence, Steady and Compliant. By knowing the DISC concept, these teenagers can get to know themselves in an effort to develop personality and increase human resources.
EFISIENSI PEKERJAAN PEMANCANGAN DENGAN ALAT DIESEL HAMMER DAN HYDRAULIC HAMMER (Studi Kasus Pembangunan Jembatan Sungai Kambu, Kota Kendari)
Authors: Hadafia’dy Hadafia’dy , Sarita Umran , Minmahddun Anafi
Published: June 2023

Pembangunan Jembatan Sungai Kambu merupakan salah satu proyek dimana pondasi yang digunakan adalah jenis tiang pancang. Dalam proses pemancangannya dipakai diesel hammer. Hal ini karena kondisi lapangan serta biaya karena pemancangan yang cukup lama. Namun bukan berarti tidak ada alternatif alat pancang lain yang bisa dipakai. Hydraulic hammer dipilih sebagai pembanding dari diesel hammer. Alat tersebut dipilih karena karakteristik yang hampir sama dengan diesel hammer. Pemilihan alat pancang yang lebih cepat akan mempengaruhi durasi pekerjaan dalam menyelesaikan proyek. Berdasarkan hasil perhitungan produktivitas, waktu dan biaya yang dibutuhkan dari masing-masing alat untuk diesel hammer 73 hari dengan biaya Rp. 593.529.176, sedangkan hydraulic hammer selama 63 hari dengan biaya sebesar Rp. 552.958.056.
Tinjauan Analisa Beban Kerja Pada Abutmen Studi Kasus Jembatan Roraya (Anese) Konawe Selatan
Authors: Syahri Alfi , Masdiana Masdiana , Minmahddun Anafi
Published: June 2023

Karena banyaknya kendaraan dan beban lain yang membebani jembatan, maka kekuatan abutment pada jembatan yang digunakan sebagai prasarana transportasi harus didukung dengan abutment yang dapat menahan berbagai beban agar jembatan tidak roboh. Pembangunan jembatan harus benar-benar berdasarkan perhitungan faktor kestabilan dan keselamatan, karena kesalahan yang terjadi dalam pembangunan jembatan dapat berakibat fatal yaitu kerugian harta benda dan korban jiwa. Sebuah jembatan dikatakan aman jika abutment yang digunakan sebagai penyangga jembatan telah memperhatikan faktor keamanan, baik terhadap bahaya pergeseran maupun bahaya terguling. Dalam analisis kekuatan abutment, perhitungan kestabilan merupakan salah satu aspek yang tidak boleh diabaikan atau dikesampingkan.
PENGARUH PENAMBAHAN FLY ASH TERHADAP NILAI KUAT GESER LANGSUNG PADA PASIR KASAR DENGAN DERAJAT KEJENUHAN 50% 70% DAN 100%
Authors: Shandi Jery , Simatupang Minsin , Mustika Wayan , Minmahddun Anafi
Published: June 2023

Pasir adalah bahan material yang memiliki bentuk butiran. Butiran-butiran pada pasir, umumnya memiliki ukuran yang berkisar antara 0,0625 mm sampai 2 mm. Materi yang membentuk pasir adalah silikon dioksida, tetapi pada beberapa daerah pantai tropis dan subtropis, pasir umumnya terbentuk dari batuan kapur. Tujuan penelitian ini adalah untuk mengetahui pengaruh penambahan fly ash terhadap nilai kuat geser langsung pada pasir kasar dengan derajat kejenuhan 50%, 70% dan 100%. Jenis penelitian ini menggunakan metode trial and error. Sampel dalam penelitian ini  menggunakan Fly Ash, pengujian uji kuat geser langsung menggunakan alat uji Direct Shear. Hasil pengujian menunjukkan bahwa penambahan Pemberian  kadar fly ash 20% dengan persentase derajat kejenuhan 50%, 70% dan 100% seiring bertambahnya persentase tidak dapat meningkatkan nilai kuat geser. Saran untuk penelitian ini perlunya penambahan waktu agar mendapatkan kekuatan maksimum pergeseran sampel benda uji.
EFISIENSI BIAYA DAN WAKTU PELAKSANAAN PEKERJAAN LAPIS PERKERASAN AGREGAT KELAS B PADA RUAS JALAN SORUMBA KOTA KENDARI
Authors: Haji Laode , Nashrun Mappa , Sarita Umran , Mas'ud Fitriah , Soeparyanto Try Sugiyarto
Published: June 2023

Dalam merencanakan proyek yang dikerjakan dengan alat berat, satu hal yang penting adalah bagaimana menghitung efisiensi biaya dan waktu alat berat. Langkah pertama dalam menghitung biaya dan waktu alat berat adalah melakukan perhitungan secara teoritis. Kemudian dengan adanya tugas akhir ini untuk mengetahui efisiensi biaya dan waktu alat berat yang digunakan selama proses proyek Peningkatan Jalan Kawasan Wua Wua (DAK 2019) – Jalan Sorumba, Kota Kendari. Data dalam penelitian ini adalah data sekunder yang diperoleh dari kontraktor pelaksana yang meliputi laporan rencana anggaran biaya proses pelaksanaan pekerjaan perkerasan pondasi agregat kelas B. Adapun biaya pelaksanaan sewa alat dan bahan dari perhitungan yakni sebesar Rp. 1.581.019.052,29, sedangkan nilai dari biaya kontrak yakni sebesar Rp. 1.597.496.916,63. Waktu pelaksanaan pekerjaan perkerasan agregat kelas B (LPB) dari perhitungan yakni membutuhkan waktu 35 (tiga puluh lima) hari kalender dan masih sesuai dengan estimasi pelaksanaan pekerjaan dalam kontrak
Tinjauan Plumbing Kebutuhan Air Bersih Pada Gedung Program Pendidikan Vokasi Universitas Halu Oleo
Authors: Ridwan Muhammad Reza , Talanipa Romy , Razak Erich Nov Putra , Sulha Sulha
Published: June 2023

Gedung program pendidkan vokasi universitas halu oleo Memiliki luas gedung 562,5m² di setiap lantainya, demi mendukung kapasitas serta fungsi dari gedung itu. Teknik dalam pengumpulan data pada studi lapangan meliputi: (1) obsevasi lapangan, (2) wawancara, (3) dokumentasi. Studi lapangan ini bertujuan untuk mengetahui metode Tinjauan Plumbing Pada Gedung Program Pendidikan Vokasi Universitas Halu Oleo. Hasil pembahasan laporan ini Tinjauan Plumbing Pada Gedung Program Pendidikan Vokasi Universitas Halu Oleo ini adalah : (1) menggunakan metode luas lantai efektif pada gedung program Pendidikan vokasi, (2) menghitung kebutuhan air bersih berdasarkan jenis dan jumlah alat plumbing, (3) perhitungan kebutuhan air bersih berdasarkan unit alat plambing, (4) menghitung kapasitas volume reservoir pada gedung program pendidikan vokasi, (5) mengetahui jumlah dan jenis alat plumbing pada gedung program Pendidikan vokasi. Adapun kesimpulan yang didapat dari hasil perhitungan adalah kebutuhan air bersih pada gedung program Pendidikan vokasi 9,44 m³/hari/orang atau 9440 L/hari/orang. Volume kapasitas reservoir pada gedung 2,467 liter. Dan memiliki jumlah alat sebanyak 46 buah , water closet 12 buah, urinal 9 buah, lavatory 12 buah, jet shower 12 buah dan faucent 1 buah.
PENGUJIAN TASIRTU PADAKURU SEBAGAI LAPIS PONDASI AGREGAT KELAS B PADA PERKERASAN JALAN
Authors: Vionita Risma , Sulha Sulha , Adityawan Muhammad Handy Dwi , Minmahddun Anafi
Published: June 2023

Salah satu sumber material di Sulawesi Tenggara yang cukup potensial untuk digunakan adalah material yang berasal dari Desa Padakuru, Kecamatan  Wangi-Wangi, Kabupaten Wakatobi.Dimana material di lokasi tersebut sudah lama dimanfaatkan oleh masyarakat sekitarnya untuk keperluan bahan konstruksi bangunan sipil, sedangkan pemeriksaan mutu material khususnya sebagai bahan timbunan pilihan, dalam hal ini karakteristik dan spesifikasi perlu diketahui.Tujuan dari penelitian ini adalah untuk mengetahui karakteristik dan spesifikasi material sebagai bahan timbunan agregat kelas B jalan dengan mengacu pada spesifikasi yang disyaratkan dengan Standar Nasional Indonesia (SNI) Bidang Bina Marga.Metode ini yang dilakukan adalah melakukan survey dan meninjau luas wilayah, kondisi dan material dari Desa Padakuru, dengan tujuan untuk mengambil data-data literatur yang diperlukan Metode-metode ini  dibutuhkan untuk mendapatkan Data Primer seperti data hasil pengujian Laboratoriumdan data sekunder seperti data yang didapat pada jurnal dan hasil penelitian terdahulu.Hasil dari pengujian ini adalah pada pengujian karakteristik analisa saringan tidak memenuhi spesifikasi agregat kelas B berdasarkan  Standar Nasional Indonesia (SNI) Bidang Bina Marga, berdasarkan uji keausan, kepadatan dan nilai CBR telah memenuhi spesifikasi dengan nilai keausan 37,45% pengujian kepadatan maksimum 1.692 g/cm3, dan nilai CBR 62%.
RANCANGAN BIAYA PELAKSANAAN BERDASARKAN DATA KONTRAK PADA PEKERJAAN AC-BC (PROYEK REKONSTRUKSI JALAN BALAI KOTA DAN TEBAUNUNGGU KENDARI
Authors: Jayanti Ice , Mursidi Baso , Mustika Wayan , Soeparyanto Try Sugiyarto
Published: June 2023

Perkembangan jalan raya merupakan salah satu hal yang selalu berjalan seiring dengan kemajuan teknologi dan pemikiran manusia yang menggunakannya, karena jalan merupakan fasilitas yang penting bagi manusia untuk dapat menjangkau suatu daerah yang ingin dicapainya. Sehubungan dengan itu, Pemerintah Kota Kendari melaksanakan proyek perbaikan Jalan Balai Kota dan Tebau Kota Kendari Sulawesi Tenggara dengan panjang 375 m dan lebar jalan 12 m. Pembangunan ini bertujuan untuk mendapatkan rencana jalan yang aman, nyaman dan ekonomis. Metode pengumpulan data yang digunakan dalam penelitian ini adalah observasi lapangan dengan melakukan survei langsung di lokasi penelitian. Dari hasil perhitungan RAB pekerjaan AC-BC maka total biaya pekerjaan untuk semua item pekerjaan AC-BC adalah Rp. 9.000.000,- total harga pekerjaan penyemprotan prime coat adalah Rp. 94.483.732, total harga pekerjaan peletakan adalah Rp.763.474.299,68 dan total biaya pekerjaan pemadatan adalah Rp.14.018.973.92. Total biaya seluruh ruas jalan AC-BC yaitu Rp. 969.074.706.69.
TINJAUAN PERENCANAAN DETAIL STRUKTUR KOLOM PADA REVITALISASI TERMINAL PENUMPANG TYPE A PUUWATU TERHADAP SNI 2847-2019
Authors: Kimsan Masykur , Meilani Sindi , Rizal Muhammad
Published: June 2023

Perkembangan penelitian kolom dalam menahan gaya seismik telah berlangsung sangat pesat seiring dengan perkembangan teknologi material beton dan baja, baik dari segi kekuatan maupun keberlanjutan. Hal ini diikuti pula oleh berkembanganya pedoman perencanaan untuk struktur bangunan gedung di Indonesia. Sebagai salah satu bangunan publik, pekerjaan gedung terminal penumpang type A puuwatu Kota Kendari, khususnya perencanaan detailing kolom, perlu diuji kesesuainnya terhadap SNI 2847-2019. Hal ini penting untuk mengetahui apakah perencanaan detailing kolomnya sudah memenuhi persyaratan terkini. Studi perbandingan ini menunjukkan detailing kolom sudah sesuai dengan ketentuan yang disyaratkan dalam SNI 2847-2019, untuk menahan beban gempa.
TINJAUAN KELAYAKAN PASIR PANTAI LABUAN KECAMATAN WAKORUMBA UTARA SEBAGAI PENYUSUN MORTAR
Authors: Jhosiardan Jhosirdan , Masdiana Masdiana , Balthasar Awill
Published: June 2023

Pada penelitian ini dipergunakan pasir pantai yang ada dipantai labuan kecamatan wakorumba utara. Penambahan pasir dilakukan untuk memenuhi permintaan masyarakat khususnya masyarakat didaerah pantai. Kuat tekan rata-rata mortar dengan pemakaian pasir pantai untuk bahan bangunan seperti mortar dapat dilakukan dengan komposisi kuat tekan rata-rata mortar tersebut umur 7  hari dan 28 hari masing-masing 6  buah benda uji kubus dengan ukuran 10 x 10 x 10 cm. Hasil kuat tekan mortar dengan menggunakan pasir labuan dengan variansi komposisi 1:4  dan 1:5 yang dicuci dan tidak dicuci. komposisi 1:4 tidak dicuci pada umur 7 hari adalah 43,33 kg/cm² dan 28 hari 71,67 kg/cm² sedangkan dicuci pada umur 7 hari adalah 45 kg/cm² dan 28 hari 81,67 kg/cm². komposis 1:5 tidak dicuci pada umur 7 hari adalah 30 kg/cm² dan 28 hari adalah 65 kg/cm² sedangkan dicuci pada umur 7 hari adalah 43,33 kg/cm² dan 28 hari adalah 71, 67 kg/cm²
PENERAPAN MODEL KOOPERATIF TIPE THE POWER OF TWO UNTUK MENINGKATKAN KERJASAMA DAN HASIL BELAJAR
Authors: Mira Marti
Published: June 2023

This study is purposed to describe the implementation of cooperative learning the power of two type to improve the studentsâ€™ cooperation, learning outcomes, and the effectivity on the implementation of cooperative learning the power of two type in improving the studentsâ€™ learning outcomes. The study was held by using Classroom Action Research (CAR) and quasi experiment. The subject of the CAR was class XI IPS 3 of SMAN 03 Mukomuko, class XI IPS 2 of SMAN 03 as the experiment class and class XI IPS 1 as the control class. This research used total sample and observation method. Observation sheet were used to measure the teacherâ€™s ability in implementing the learning model and the studentsâ€™ ccooperation and also written test to measure the improvement of the studentâ€™s learning outcomes. The data were gained then analyzed according to the type of the data, the qualitative data were analyzed qualitatively and also the quantitative one that was analyzed by using average formula andÂ  dependent and independent sample t-test. Based on the research during three cycles in class XI IPS 3, the result of the analysis showed that the teacherâ€™s ability in implementing the learning model got some improvement during the implementation.Â  The studentsâ€™ cooperation and their learning outcomes got some improvements from the first until the third cycle following the teachersâ€™ ability in implementing the cooperative learning model the power of two type. The conclusions of the research were the implementation of cooperative learning model the power of two type was able to improve the studentsâ€™ cooperation and their learning outcomes, the implementation of cooperative learning model the power of two type was more effective to improve the studentsâ€™ learning outcomes than the conventional model on economy subject in class XI IPS of SMAN 03 Mukomuko.
MENJADI GURU PROFESIONAL DI ERA DIGITAL
Authors: Budiana Irma
Published: June 2023

This research aims to study or study professional teachers in the digital age. This type of research is qualitative. The study of professional teachers in this digital era aims to add insight to teachers and prospective teachers to become professional teachers in the digital era. Being professional means being an expert in your field. But not all experts can be qualified because being qualified is not only an expert problem, but also concerns personality and integrity issues. Being a professional is a unity between integrity and personality combined with his skills. Professional teachers must create a superior school and produce graduates/outputs of quality, great and dignified education. Schools that have educational excellence and success are influenced by the performance of individuals and organizations themselves which include beliefs, cultures, values, and behavioral norms referred to as the human side of organization (human and organizational aspects). Based on the results of the research concluded that (1) professional teachers are teachers who are skilled and experts in carrying out their profession and have received formal recognition based on applicable provisions, both related to their educational background and their position. (2) The digital age is a term often used in the emergence of digital technology or internet networks. This digital era is a time when everyone is technologically literate and all connected, and in this era is a time when all humans can interact and communicate closely even though they are far apart. (3) Being a professional teacher must be qualified and have various competencies relevant to his profession, and have a high motivation to always improve professionalism in order to have competence in accordance with the laws and regulations so as to be able to carry out their duties and obligations in learning / guidance.
MODEL KEPEMIMPINAN BERPIKIR SISTEM PRASEKOLAH ISLAM SWASTA
Authors: Saputra Awang , Gunawan Agus , Fauzi Muhamad
Published: June 2023

The purpose of this paper is to explain the concept of systems thinking in the era of society 5.0 in the field of preschool education has a significant contribution and describes the thinking leadership of the private Islamic preschool level system. This research is qualitative research with a library research approach based on thematic in collecting data sourced from the internet, including books, journals and reports. Data analysis technique using content analysis. The system thinking concept is the way of thinking about the responsibilities organization with various problems and the need for solutions using systems thinking approach that is interrelated and affects. The educational leadership approach through classical, contextual, and identity studies that prioritize organizational leadership through planning, implementation, monitoring, and evaluation is appropriate for leaders for their leadership. The connection with education is that the leader of educational institutions must accumulate problems and their solution, of course, involves systems thinking. Levels of systems thinking can be applied at the preschool level with low levels of thinking, intermediate systems thinking, middle-high systems thinking, and high systems thinking. Islamic preschool education entirely teaches knowledge and understanding of the Islamic religion as the basis for the next level of education, experience, memorization, application, and future life. The Islamic education teaches systems thinking about the critical level to be trained as early as possible, the process of Islamic education becomes the primary curriculum in education.
PENINGKATAN HASIL BELAJAR SISWA MELALUI MEDIA DOMINO MATEMATIKA (DOMIKA) PADA SISWA KELAS VIIA SMPN 1 CIKARANG BARAT
Authors: Mumpuni Mumpuni
Published: June 2023

The improvement of the quality of education can be seen from the achievements achieved by students, while the success of the achievement of mathematics learning results can be seen from the ability of students in solving integer operation problems correctly, although in general, not all students can solve integer operation problems, therefore it is expected that mathematical domino media (DOMIKA) can train students in performing calculation operations so that they are embedded in the carrying nature.Â  conscious students. The purpose of this study is to find out the improvement of integer operation learning outcomes through mathematical domino media (DOMIKA) in students of class VII A SMPN 1 Cikarang Barat Bekasi Regency. This research includes a type of classroom action research (PTK), with its main characteristic being repeated actions and the main method is self-reflection aimed at improving learning. PTK is a problem-solving activity characterized by cyclic and reflection that starts from: a) planning, b) actions, c) observing, d) analyzing data/information to decide the extent of the advantages and disadvantages of such actions (reflecting). PTK is characterized by continuous improvement so that research satisfaction is often the benchmark of the cycle. In this first cycle, learning results were obtained with an average score of SMPN 1 Cikarang Barat students in Bekasi Regency of 69 and classically the completeness of student learning results was obtained by 65,625% with a frequency of 21 people out of 32 students present categorized as complete and 34,375% with a frequency of 11 people out of 32 students categorized as incomplete. From these results, it can be stated that the completeness of student learning to the maximum has not been achieved. In cycle II, learning results were obtained with the average score of SMPN 1 Cikarang Barat Students in Bekasi Regency of 80, and classically the percentage of completeness of the learning outcomes of SMPN 1 Cikarang Barat Bekasi Regency reached 93.75% with the number of frequencies of 30 people from 32 students present said to be complete and 6.25% with the number of frequencies of 2 people from 32 students categorized as unfinished. From these results, it can be stated that the application of mathematical domino learning media (DOMIKA) in cycle II is on target.
PEMBINAAAN ORANG TUA DALAM PEMBENTUKAN KARAKTER PESERTA DIDIK DI MTS KECAMATAN MALANGKE
Authors: Ali Fathudin
Published: June 2023

This study aims to describe the guidance of parents of MTs students. in Malangke District in instilling character. This study uses a qualitative research that uses a pedagogical approach. Sources of data are primary data from parents, school principals, PAI teachers through interviews, while secondary data is taken from documents related to research. The instrument used in data collection is the researcher himself whose function is to determine and select informants as data sources, analyze data, interpret data, and instruments in collecting data are observation, interviews, and documentation. The results of the research and analysis concluded that in parenting in the formation of the character of MTs. Malangke 1) The pattern of parents in coaching in instilling character a. MTs. Cappasolo, the parenting style used by the community is a democratic pattern. B. MTs. Tokke, the parenting style used by the community is an authoritarian pattern, 2) The basic development of religion in MTs. Cappasolo and MTs. Tokke applied by parents in Malangke sub-district tends to be the same, the way to instill character and character at home is to set an example. 3) Many things can hinder the formation of character so that students do not show character such as education level, cultural environment, age, socioeconomic level.
Comparative microRNA profiling of Trypanosoma cruzi infected human cells
Authors: Rego Natalia , Libisch María Gabriela , Rovira Carlos , Tosar Juan Pablo , Robello Carlos
Published: June 2023

Introduction

Trypanosoma cruzi, the causative agent of Chagas disease, can infect almost any nucleated cell in the mammalian host. Although previous studies have described the transcriptomic changes that occur in host cells during parasite infection, the understanding of the role of post-transcriptional regulation in this process is limited. MicroRNAs, a class of short non-coding RNAs, are key players in regulating gene expression at the post-transcriptional level, and their involvement in the host-T. cruzi interplay is a growing area of research. However, to our knowledge, there are no comparative studies on the microRNA changes that occur in different cell types in response to T. cruzi infection.

Methods and results

Here we investigated microRNA changes in epithelial cells, cardiomyocytes and macrophages infected with T. cruzi for 24 hours, using small RNA sequencing followed by careful bioinformatics analysis. We show that, although microRNAs are highly cell type-specific, a signature of three microRNAs -miR-146a, miR-708 and miR-1246, emerges as consistently responsive to T. cruzi infection across representative human cell types. T. cruzi lacks canonical microRNA-induced silencing mechanisms and we confirm that it does not produce any small RNA that mimics known host microRNAs. We found that macrophages show a broad response to parasite infection, while microRNA changes in epithelial and cardiomyocytes are modest. Complementary data indicated that cardiomyocyte response may be greater at early time points of infection.

Conclusions

Our findings emphasize the significance of considering microRNA changes at the cellular level and complement previous studies conducted at higher organizational levels, such as heart samples. While miR-146a has been previously implicated in T. cruzi infection, similarly to its involvement in many other immunological responses, miR-1246 and miR-708 are demonstrated here for the first time. Given their expression in multiple cell types, we anticipate our work as a starting point for future investigations into their role in the post-transcriptional regulation of T. cruzi infected cells and their potential as biomarkers for Chagas disease.
A machine learning evaluation of patient characteristics associated with prescribing of guideline-directed medical therapy for heart failure
Authors: Kim Rachel , Suresh Krithika , Rosenberg Michael A. , Tan Malinda S. , Malone Daniel C. , Allen Larry A. , Kao David P. , Anderson Heather D. , Tiwari Premanand , Trinkley Katy E.
Published: June 2023

Introduction/background

Patients with heart failure and reduced ejection fraction (HFrEF) are consistently underprescribed guideline-directed medications. Although many barriers to prescribing are known, identification of these barriers has relied on traditional a priori hypotheses or qualitative methods. Machine learning can overcome many limitations of traditional methods to capture complex relationships in data and lead to a more comprehensive understanding of the underpinnings driving underprescribing. Here, we used machine learning methods and routinely available electronic health record data to identify predictors of prescribing.

Methods

We evaluated the predictive performance of machine learning algorithms to predict prescription of four types of medications for adults with HFrEF: angiotensin converting enzyme inhibitor/angiotensin receptor blocker (ACE/ARB), angiotensin receptor-neprilysin inhibitor (ARNI), evidence-based beta blocker (BB), or mineralocorticoid receptor antagonist (MRA). The models with the best predictive performance were used to identify the top 20 characteristics associated with prescribing each medication type. Shapley values were used to provide insight into the importance and direction of the predictor relationships with medication prescribing.

Results

For 3,832 patients meeting the inclusion criteria, 70% were prescribed an ACE/ARB, 8% an ARNI, 75% a BB, and 40% an MRA. The best-predicting model for each medication type was a random forest (area under the curve: 0.788–0.821; Brier score: 0.063–0.185). Across all medications, top predictors of prescribing included prescription of other evidence-based medications and younger age. Unique to prescribing an ARNI, the top predictors included lack of diagnoses of chronic kidney disease, chronic obstructive pulmonary disease, or hypotension, as well as being in a relationship, nontobacco use, and alcohol use.

Discussion/conclusions

We identified multiple predictors of prescribing for HFrEF medications that are being used to strategically design interventions to address barriers to prescribing and to inform further investigations. The machine learning approach used in this study to identify predictors of suboptimal prescribing can also be used by other health systems to identify and address locally relevant gaps and solutions to prescribing.
Mechanism of fibroblast growth factor 21 in cardiac remodeling
Authors: Zhao Zeyu , Cui Xuemei , Liao Zhangping
Published: June 2023

Cardiac remodeling is a basic pathological process that enables the progression of multiple cardiac diseases to heart failure. Fibroblast growth factor 21 is considered a regulator in maintaining energy homeostasis and shows a positive role in preventing damage caused by cardiac diseases. This review mainly summarizes the effects and related mechanisms of fibroblast growth factor 21 on pathological processes associated with cardiac remodeling, based on a variety of cells of myocardial tissue. The possibility of Fibroblast growth factor 21 as a promising treatment for the cardiac remodeling process will also be discussed.
Solution-processed pristine metal oxides as electron-transporting materials for perovskite solar cells
Authors: Sharma Harshit , Srivastava Ritu
Published: June 2023

In recent years, perovskite material-based photovoltaic devices have attracted great attention of researchers because of an expeditious improvement in their efficiency from 3.8% to over 25%. The electron transport layer (ETL), which functions for the extraction and transportation of photogenerated electrons from active perovskite material to the electrodes, is a vital part of these perovskite solar cells (PSCs). The optoelectronic properties of these electron transport layer materials also have an impact on the performance of these perovskite solar cells, and for commercialized flexible perovskite solar cells, low-temperature and solution-processable electron transport layers having high stability and suitable optoelectronic properties are needed. In this regard, the solution-processable films of different metal oxides have been largely investigated by many research groups. So, this review summarizes the optoelectronic properties of the different metal oxide-based electron transport layers and the development in the performance of the perovskite solar cells, which have solution-processable metal oxides as electron transport layers.
The female upper reproductive tract harbors endogenous microbial profiles
Authors: Canha-Gouveia Analuce , Pérez-Prieto Inmaculada , Rodríguez Carmen Martínez , Escamez Teresa , Leonés-Baños Irene , Salas-Espejo Eduardo , Prieto-Sánchez Maria Teresa , Sánchez-Ferrer Maria Luisa , Coy Pilar , Altmäe Signe
Published: June 2023

Introduction

The female reproductive tract harbours unique microbial communities (known as microbiota) which have been associated with reproductive functions in health and disease. While endometrial microbiome studies have shown that the uterus possesses higher bacterial diversity and richness compared to the vagina, the knowledge regarding the composition of the Fallopian tubes (FT) is lacking, especially in fertile women without any underlying conditions.

Methods

To address this gap, our study included 19 patients who underwent abdominal hysterectomy for benign uterine pathology, and 5 women who underwent tubal ligation as a permanent contraceptive method at Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA). We analyzed the microbiome of samples collected from the FT and endometrium using 16S rRNA gene sequencing.

Results

Our findings revealed distinct microbiome profiles in the endometrial and FT samples, indicating that the upper reproductive tract harbors an endogenous microbiome. However, these two sites also shared some similarities, with 69% of the detected taxa Being common to both. Interestingly, we identified seventeen bacterial taxa exclusively present in the FT samples, including the genera Enhydrobacter, Granulicatella, Haemophilus, Rhizobium, Alistipes, and Paracoccus, among others. On the other hand, 10 bacterial taxa were only found in the endometrium, including the genera Klebsiella, Olsenella, Oscillibacter and Veillonella (FDR <0.05). Furthermore, our study highlighted the influence of the endometrial collection method on the findings. Samples obtained transcervically showed a dominance of the genus Lactobacillus, which may indicate potential vaginal contamination. In contrast, uterine samples obtained through hysterescopy revealed higher abundance of the genera Acinetobacter, Arthrobacter, Coprococcus, Methylobacterium, Prevotella, Roseburia, Staphylococcus, and Streptococcus.

Discussion

Although the upper reproductive tract appears to have a low microbial biomass, our results suggest that the endometrial and FT microbiome is unique to each individual. In fact, samples obtained from the same individual showed more microbial similarity between the endometrium and FT compared to samples from different women. Understanding the composition of the female upper reproductive microbiome provides valuable insights into the natural microenvironment where processes such as oocyte fertilization, embryo development and implantation occur. This knowledge can improve in vitro fertilization and embryo culture conditions for the treatment of infertility.