bluuebunny/crossref_metadata_2025 huggingface dataset:
Costa Resiliente: A Serious Game Co-Designed to Foster Resilience Thinking
Authors: Olivares-Rodríguez Cristian , Villagra Paula , Mardones Rodolfo E. , Cárcamo-Ulloa Luis , Jaramillo Nicolás
Published: December 2022

Resilience thinking is critical for improving disaster preparedness, response, and adaptation. While there are several strategies focused on assessing resilience capacity in human communities, there are few strategies focused on fostering resilience thinking. Game-based learning is an active and immersive teaching strategy that can foster complex skills such as resilience. However, this field needs further research in terms of its potential to strengthen community resilience to disasters. In this paper, we validated a serious game to foster community resilience. We present the collaborative creation process for the development of the board game Costa Resiliente, and its subsequent migration into a video game. We have developed an experimental study to evaluate the contributions of the mobile game against the board game. The result is a technological tool based on scientific knowledge to foster resilience thinking in coastal human communities exposed to hazards. The board game was developed using data from local research on community resilience, and from experts in emergency planning and developing games collected in focus groups. The board game’s effect on fostering resilience thinking was validated with school students from a coastal town. During the migration process into a video game, we used a design thinking methodological approach for the co-creation of audiovisual elements, in which beneficiaries participate actively and early. Through this approach, visual and auditory elements that are familiar to coastal communities were integrated into the video game elements. Our study indicates that game-based learning is a useful approach to foster resilience thinking, and that a better gaming experience can be provided by a video game. The potential of this video game for educating young age groups about community resilience is further discussed.
A Reliable and Cost-Efficient PCR-RFLP Tool for the Rapid Identification of Cetaceans in the Mediterranean Sea
Authors: Brustenga Leonardo , Chiesa Stefania , Maltese Silvia , Consales Guia , Marsili Letizia , Lauriano Giancarlo , Scarano Vincenzo , Scarpato Alfonso , Lucentini Livia
Published: December 2022

Twenty-five species of cetaceans have been reported throughout the Mediterranean Sea, eight of them are commonly distributed in the whole basin and are regularly found beached or adrift in the sea. Stranded animals are frequently found in poor conservation status, preventing reliable identification; identification is thus often based solely on morphological features. Therewith, molecular tools are especially useful to provide taxonomic identification. In this work, a four-enzymes PCR-RFLP in silico protocol, based on a fragment of the mitochondrial gene cytb, has been designed for cetacean species occurring in the Mediterranean Sea. Moreover, beached or floating specimen samples belonging to the eight common species have been tested in the laboratory, providing evidence that this approach represents a reliable, cost- and time-effective tool for their specific identification.
Confidence Levels Complex q-Rung Orthopair Fuzzy Aggregation Operators and Its Application in Decision Making Problem
Authors: Qiyas Muhammad , Naeem Muhammad , Khan Neelam
Published: December 2022

The theory investigated in this analysis is substantially more suitable for evaluating the dilemmas in real life to manage complicated, risk-illustrating, and asymmetric information. The complex Pythagorean fuzzy set is expanded upon by the complex q-rung orthopair fuzzy set (Cq-ROFS). They stand out by having a qth power of the real part of the complex-valued membership degree and a qth power of the real part and imaginary part of the complex-valued non-membership degree that is equal to or less than 1. We define the comparison method for two complex q-rung orthopair fuzzy numbers as well as the score and accuracy functions (Cq-ROFNs). Some averaging and geometric aggregation operators are examined using the Cq-ROFSs operational rules. Additionally, their main characteristics have been fully illustrated. Based on the suggested operators, we give a novel approach to solve the multi-attribute group decision-making issues that arise in environmental contexts. Making the best choice when there are asymmetric types of information offered by different specialists is the major goal of this work. Finally, we used real data to choose an ideal extinguisher from a variety of options in order to show the effectiveness of our decision-making technique. The effectiveness of the experimental outcomes compared to earlier research efforts is then shown by comparing them to other methods.
A Theoretical Development of Cubic Pythagorean Fuzzy Soft Set with Its Application in Multi-Attribute Decision Making
Authors: Saeed Muhammad , Saeed Muhammad Haris , Shafaqat Rimsha , Sessa Salvatore , Ishtiaq Umar , di Martino Ferdinando
Published: December 2022

Scientific progression has allowed researchers to develop novel and innovative ways to deal with uncertainty in data, allowing for the development of more precise and accurate data representation models. This paper aims to extend an already reported concept of Cubic Pythagorean fuzzy set to Cubic Pythagorean Fuzzy Soft Set (CPFSs) as it incorporates both interval-valued Pythagorean fuzzy sets (IVPFS) and Pythagorean fuzzy sets (PFS) at the same time, providing a more targeted approach to deal with uncertainty. This hybrid structure can better handle data in comparison to the ones in the literature by having the characteristics of PFS and soft sets, leading to a more targeted approach to handle attributes in decision-making studies. In this study, we defined various internals and externals of CPFSs, set operators, aggregation operators, and developed an algorithm based on distance measures for (CPFSs), which are applied in a disease diagnostic decision-making problem.
Crossover Dynamics of Rotavirus Disease under Fractional Piecewise Derivative with Vaccination Effects: Simulations with Real Data from Thailand, West Africa, and the US
Authors: Naowarat Surapol , Ahmad Shabir , Saifullah Sayed , Sen Manuel De la , Akgül Ali
Published: December 2022

Many diseases are caused by viruses of different symmetrical shapes. Rotavirus particles are approximately 75 nm in diameter. They have icosahedral symmetry and particles that possess two concentric protein shells, or capsids. In this research, using a piecewise derivative framework with singular and non-singular kernels, we investigate the evolution of rotavirus with regard to the effect of vaccination. For the considered model, the existence of a solution of the piecewise rotavirus model is investigated via fixed-point results. The Adam–Bashforth numerical method along with the Newton polynomial is implemented to deduce the numerical solution of the considered model. Various versions of the stability of the solution of the piecewise rotavirus model are presented using the Ulam–Hyres concept and nonlinear analysis. We use MATLAB to perform the numerical simulation for a few fractional orders to study the crossover dynamics and evolution and effect of vaccination on rotavirus disease. To check the validity of the proposed approach, we compared our simulated results with real data from various countries.
Some New Parameterized Quantum Fractional Integral Inequalities Involving s-Convex Functions and Applications
Authors: Kashuri Artion , Samraiz Muhammad , Rahman Gauhar , Nonlaopon Kamsing
Published: December 2022

Convexity performs the appropriate role in the theoretical study of inequalities according to the nature and behavior. Its significance is raised by the strong connection between symmetry and convexity. In this article, we consider a new parameterized quantum fractional integral identity. By applying this identity, we obtain as main results some integral inequalities of trapezium, midpoint and Simpson’s type pertaining to s-convex functions. Moreover, we deduce several special cases, which are discussed in detail. To validate our theoretical findings, an example and application to special means of positive real numbers are presented. Numerical analysis investigation shows that the mixed fractional calculus with quantum calculus give better estimates compared with fractional calculus or quantum calculus separately.
Possible Mechanisms of the Interplay between Drugs and Mycotoxins—Is There a Possible Impact?
Authors: Lootens Orphélie , Vermeulen An , Croubels Siska , De Saeger Sarah , Van Bocxlaer Jan , De Boevre Marthe
Published: December 2022

Mycotoxin contamination is a global food safety issue leading to major public health concerns. Repeated exposure to multiple mycotoxins not only has repercussions on human health but could theoretically also lead to interactions with other xenobiotic substances—such as drugs—in the body by altering their pharmacokinetics and/or pharmacodynamics. The combined effects of chronic drug use and mycotoxin exposure need to be well understood in order to draw valid conclusions and, in due course, to develop guidelines. The aim of this review is to focus on food contaminants, more precisely on mycotoxins, and drugs. First, a description of relevant mycotoxins and their effects on human health and metabolism is presented. The potential for interactions of mycotoxins with drugs using in vitro and in vivo animal experiments is summarized. Predictive software tools for unraveling mycotoxin–drug interactions are proposed and future perspectives on this emerging topic are highlighted with a view to evaluate associated risks and to focus on precision medicine. In vitro and in vivo animal studies have shown that mycotoxins affect CYP450 enzyme activity. An impact from drugs on mycotoxins mediated via CYP450-enzymes is plausible; however, an impact of mycotoxins on drugs is less likely considering the much smaller dose exposure to mycotoxins. Drugs that are CYP450 perpetrators and/or substrates potentially influence the metabolism of mycotoxins, metabolized via these CYP450 enzymes. To date, very little research has been conducted on this matter. The only statistically sound reports describe mycotoxins as victims and drugs as perpetrators in interactions; however, more analysis on mycotoxin–drug interactions needs to be performed.
Multiple Mutations Associated with Emergent Variants Can Be Detected as Low-Frequency Mutations in Early SARS-CoV-2 Pandemic Clinical Samples
Authors: Kimbrel Jeffrey , Moon Joseph , Avila-Herrera Aram , Martí Jose Manuel , Thissen James , Mulakken Nisha , Sandholtz Sarah H. , Ferrell Tyshawn , Daum Chris , Hall Sara , Segelke Brent , Arrildt Kathryn T. , Messenger Sharon , Wadford Debra A. , Jaing Crystal , Allen Jonathan E. , Borucki Monica K.
Published: December 2022

Genetic analysis of intra-host viral populations provides unique insight into pre-emergent mutations that may contribute to the genotype of future variants. Clinical samples positive for SARS-CoV-2 collected in California during the first months of the pandemic were sequenced to define the dynamics of mutation emergence as the virus became established in the state. Deep sequencing of 90 nasopharyngeal samples showed that many mutations associated with the establishment of SARS-CoV-2 globally were present at varying frequencies in a majority of the samples, even those collected as the virus was first detected in the US. A subset of mutations that emerged months later in consensus sequences were detected as subconsensus members of intra-host populations. Spike mutations P681H, H655Y, and V1104L were detected prior to emergence in variant genotypes, mutations were detected at multiple positions within the furin cleavage site, and pre-emergent mutations were identified in the nucleocapsid and the envelope genes. Because many of the samples had a very high depth of coverage, a bioinformatics pipeline, “Mappgene”, was established that uses both iVar and LoFreq variant calling to enable identification of very low-frequency variants. This enabled detection of a spike protein deletion present in many samples at low frequency and associated with a variant of concern.
Spatio-Temporal Epidemiology of the Spread of African Swine Fever in Wild Boar and the Role of Environmental Factors in South Korea
Authors: Ito Satoshi , Bosch Jaime , Jeong Hyunkyu , Aguilar-Vega Cecilia , Park Jonghoon , Martínez-Avilés Marta , Sánchez-Vizcaíno Jose Manuel
Published: December 2022

Since the first confirmation of African swine fever (ASF) in domestic pig farms in South Korea in September 2019, ASF continues to expand and most notifications have been reported in wild boar populations. In this study, we first performed a spatio-temporal cluster analysis to understand ASF spread in wild boar. Secondly, generalized linear logistic regression (GLLR) model analysis was performed to identify environmental factors contributing to cluster formation. In the meantime, the basic reproduction number (R0) for each cluster was estimated to understand the growth of the epidemic. The cluster analysis resulted in the detection of 17 spatio-temporal clusters. The GLLR model analysis identified factors influencing cluster formation and indicated the possibility of estimating ASF epidemic areas based on environmental conditions. In a scenario only considering direct transmission among wild boar, R0 ranged from 1.01 to 1.5 with an average of 1.10, while, in another scenario including indirect transmission via an infected carcass, R0 ranged from 1.03 to 4.38 with an average of 1.56. We identified factors influencing ASF expansion based on spatio-temporal clusters. The results obtained would be useful for selecting priority areas for ASF control and would greatly assist in identifying efficient vaccination areas in the future.
Successful Rescue of Synthetic AcMNPV with a ~17 kb Deletion in the C1 Region of the Genome
Authors: Guo Yijia , Hu Hengrui , Xiao Han , Deng Fei , Li Jiang , Wang Manli , Hu Zhihong
Published: December 2022

Baculoviruses have been widely used as expression vectors. However, numerous genes in the baculoviral genome are non-essential for cellular infection and protein expression, making the optimisation of baculovirus expression vectors possible. We used a synthetic biological method to reduce the number of genes in a partial region of the autograph californica multiple nucleopolyhedrovirus (AcMNPV), the most widely used baculovirus expression vector. The C1 region of the AcMNPV is 46.4 kb and is subdivided into B1, B2, and B3 fragments. We first designed modified B1, B2, and B3 fragments by deleting the non-essential genes, and then synthesised complete viral genomes containing either individual modified B fragments or joint modified B fragments through transformation-related recombination in yeast. The synthetic genomes were then transfected into Sf9 cells to rescue the progeny viruses and test their infectivity. The design-build-test cycle was repeated until the ultimately rescued virus could produce progeny viruses efficiently. Finally, AcMNPV-Syn-mC1-1.1 by deleting approximately 17.2 kb, including 20 ORFs, in the C1 region, was obtained. This is essential to the synthesis of a minimal AcMNPV genome that can generate infectious progeny viruses and can be further used to optimise the foundation of baculovirus expression vectors.
Genomic Epidemiology of SARS-CoV-2 in Western Burkina Faso, West Africa
Authors: Sawadogo Yacouba , Galal Lokman , Belarbi Essia , Zongo Arsène , Schubert Grit , Leendertz Fabian , Kanteh Abdoulie , Sesay Abdul Karim , Erhart Annette , Bañuls Anne-Laure , Tarnagda Zékiba , Godreuil Sylvain , Tinto Halidou , Ouedraogo Abdoul-Salam
Published: December 2022

Background: After its initial detection in Wuhan, China, in December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of SARS-CoV-2 in Burkina Faso. Methods: Three hundred and seventy-seven SARS-CoV-2 genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score < 35) collected between 5 May 2020, and 31 January 2022 were analyzed. Genomic sequences were assigned to phylogenetic clades using NextClade and to Pango lineages using pangolin. Phylogenetic and phylogeographic analyses were performed to determine the geographical sources and time of virus introduction in Burkina Faso. Results: The analyzed SARS-CoV-2 genomes can be assigned to 10 phylogenetic clades and 27 Pango lineages already described worldwide. Our analyses revealed the important role of cross-border human mobility in the successive SARS-CoV-2 introductions in Burkina Faso from neighboring countries. Conclusions: This study provides additional insights into the genomic epidemiology of SARS-CoV-2 in West Africa. It highlights the importance of land travel in the spread of the virus and the need to rapidly implement preventive policies. Regional cross-border collaborations and the adherence of the general population to government policies are key to prevent new epidemic waves.
Current Update on Biomarkers for Detection of Cancer: Comprehensive Analysis
Authors: Kaushal Ankur , Kaur Narinder , Sharma Surbhi , Sharma Anil , Kala Deepak , Prakash Hridayesh , Gupta Shagun
Published: December 2022

Early and effective diagnosis of cancer is decisive for its proper management. In this context biomarker-based cancer diagnosis is budding as one of the promising ways for early detection, disease progression monitoring, and effective cancer therapy. Integration of Biosensing devices with different metallic/nonmetallic nanoparticles offers amplification and multiplexing capabilities for simultaneous detection of cancer biomarkers (CB’s). This study provides a comprehensive analysis of the most recent designs and fabrication methodologies designed for developing electrochemical biosensors (EB) for early detection of cancers. The role of biomarkers in cancer therapeutics is also discussed.
Knowledge, Attitudes, and Acceptance of COVID-19 Vaccines among Secondary School Pupils in Zambia: Implications for Future Educational and Sensitisation Programmes
Authors: Mudenda Steward , Mukosha Moses , Godman Brian , Fadare Joseph O. , Ogunleye Olayinka O. , Meyer Johanna C. , Skosana Phumzile , Chama Jacob , Daka Victor , Matafwali Scott K. , Chabalenge Billy , Witika Bwalya A.
Published: December 2022

The coronavirus disease 2019 (COVID-19) pandemic resulted in the closure of schools to slow the spread of the virus across populations, and the administration of vaccines to protect people from severe disease, including school children and adolescents. In Zambia, there is currently little information on the acceptance of COVID-19 vaccines among school-going children and adolescents despite their inclusion in the vaccination programme. This study assessed the knowledge, attitudes, and acceptance of COVID-19 vaccines among secondary school pupils in Lusaka, Zambia. A cross-sectional study was conducted from August 2022 to October 2022. Of the 998 participants, 646 (64.7%) were female, and 127 (12.7%) would accept to be vaccinated. Those who were willing to be vaccinated had better knowledge (68.5% vs. 56.3%) and a positive attitude (79.1% vs. 33.7%) compared to those who were hesitant. Overall, the odds of vaccine acceptance were higher among pupils who had higher knowledge scores (AOR = 11.75, 95% CI: 6.51–21.2), positive attitude scores (AOR = 9.85, 95% CI: 4.35–22.2), and those who knew a friend or relative who had died from COVID-19 (AOR = 3.27, 95% CI: 2.14–5.09). The low vaccine acceptance among pupils is of public health concern, emphasising the need for heightened sensitisation programmes that promote vaccine acceptance among pupils in Zambia.
Association between γ-Glutamyl Transpeptidase and SARS-CoV-2 Spike Antibody Titers among BNT162b2 Vaccine Recipients
Authors: Islam Zobida , Yamamoto Shohei , Mizoue Tetsuya , Oshiro Yusuke , Inamura Natsumi , Nemoto Takeshi , Konishi Maki , Ozeki Mitsuru , Sugiura Wataru , Ohmagari Norio
Published: December 2022

Background: Increased γ-glutamyl transpeptidase (GGT) levels can deplete plasma glutathione, which in turn impairs immune regulation; however, evidence on GGT levels and post-vaccine immunogenicity is lacking. Objective: To examine the association between GGT and SARS-CoV-2 spike IgG antibodies. Methods: Participants were 1479 medical staff (aged 21 to 75 years) who received a SARS-CoV-2 antibody test after their second vaccine and whose GGT levels were measured before the vaccine rollout. Elevated and highly elevated GGT levels were defined as 51–80 and ≥81 U/L, respectively. Multivariable linear regression was used to calculate the means of SARS-CoV-2 spike IgG. Results: In a basic model, both elevated and highly elevated GGT levels were associated with significantly lower antibody titers. The ratio of mean (95% CI) was 0.83 (0.72–0.97) and 0.69 (0.57–0.84) for elevated and highly elevated GGT levels, respectively. However, these associations were largely attenuated after additional adjustment for potential confounders. An inverse association between GGT levels and antibody titers was found in women [0.70 (0.51–0.97)], normal-weight adults [0.71 (0.51–0.98)], and non-drinkers [0.73 (0.46–1.14)] but not in men, overweight adults, and alcohol drinkers. Conclusions: Circulating GGT concentrations were associated with the humoral immune response after COVID-19 vaccination, but this relationship could be ascribed to confounders such as sex, BMI, and alcohol drinking rather than GGT per se.
Genetic Analysis of Torque Teno Canis Virus Identified in Republic of Korea
Authors: Kim Da-Yoon , Ahn Hee-Seop , Han Sang-Hoon , Go Hyeon-Jeong , Kim Dong-Hwi , Kim Jae-Hyeong , Lee Joong-Bok , Park Seung-Yong , Song Chang-Seon , Lee Sang-Won , Choi In-Soo
Published: December 2022

Torque teno canis virus (TTCaV) is an approximately 2.8 kb circular single-stranded DNA virus known to cause infections in dogs. However, its incidence in Republic of Korea remains unknown. In this study, 135 dog fecal samples were collected to determine TTCaV infection status in Republic of Korea. Based on polymerase chain reaction (PCR) analysis, 13 of 135 (9.6%) dogs tested positive for TTCaV. Three full-length genome sequences (GenBank IDs: MZ503910, MZ503911, and MZ503912) were obtained from the positive specimens. Phylogenetic tree construction and sequence identity, similarity plot, and recombination analyses were performed using these three full-length genomic sequences. Among the three full-length genomes, MZ503912 was determined to be a recombinant virus based on analysis with the reference TTCaV strains. This novel virus strain might have been generated by recombination between TTCaV strain KX827768 discovered in China and MZ503910 discovered in Republic of Korea. This is the first report to determine the incidence, genetic variation, and recombination of TTCaV in dogs in Republic of Korea. Further studies are needed to elucidate TTCaV pathogenesis in dogs.
Bacterial Laccases as Biocatalysts for the Remediation of Environmental Toxic Pollutants: A Green and Eco-Friendly Approach—A Review
Authors: Agarwal Neha , Solanki Vijendra Singh , Gacem Amel , Hasan Mohd Abul , Pare Brijesh , Srivastava Amrita , Singh Anupama , Yadav Virendra Kumar , Yadav Krishna Kumar , Lee Chaigoo , Lee Wonjae , Chaiprapat Sumate , Jeon Byong-Hun
Published: December 2022

Biological treatment methods for the biodegradation of anthropogenic toxic pollutants are eco-friendly in nature and are powered by a variety of microbial enzymes. Green chemistry and enzymes play a crucial role in catalyzing the biodegradation of organic and inorganic pollutants including azo dyes; polyaromatic hydrocarbons; lead; organic cyanides; aromatic amines; mono-, di-, and polyphenols; polymers; and mercury. Laccases form a prospective group of multifunctional oxidoreductase enzymes with great potential for oxidizing different categories of organic and inorganic pollutants and their diversified functions, such as pigment formation, lignin degradation, and detoxification of industrial wastes including xenobiotics mainly from the pharmaceutical, paper textile, and petrochemical industries. Therefore, it is very important to study laccases as green and environmentally friendly alternatives for the degradation of xenobiotics. This review article will cover comprehensive information about the functions and properties of bacterial laccases for a deep understanding of their scope and applications for effective bioremediation of recalcitrant xenobiotics.
Sustainable Membrane Technologies for By-Product Separation of Non-Pharmaceutical Common Compounds
Authors: Talukder Md Eman , Alam Fariya , Mishu Mst. Monira Rahman , Pervez Md. Nahid , Song Hongchen , Russo Francesca , Galiano Francesco , Stylios George K. , Figoli Alberto , Naddeo Vincenzo
Published: December 2022

The Chinese pharmaceutical industry and traditional Chinese medicine (TCM) are both vital components of Chinese culture. Some traditional methods used to prepare TCMs have lost their conformity, and as a result, are producing lower-quality medicines. In this regard, the TCM sector has been looking for new ways to boost productivity and product quality. Membrane technology is environmentally-friendly, energy-saving technology, and more efficient than traditional technologies. Membrane separation is the most effective method for separating and cleaning the ingredients of the non-pharmaceutical common compounds from traditional Chinese medicine (TCM). Membrane technology is currently being employed for the concentration, purification, and separation of TCMs. This review paper discusses how membranes are fabricated and their role in non-pharmaceutical common compound separation and TCM purification. Accordingly, the membrane applicability and the technological advantage were also analyzed in non-pharmaceutical common compound separation. Researchers pay attention to the choice of membrane pore size when selecting membranes but often ignore the influence of membrane materials and membrane structure on separation, resulting in certain blindness in the membrane selection process.
Possible Factors Driving Groundwater Quality and Its Vulnerability to Land Use, Floods, and Droughts Using Hydrochemical Analysis and GIS Approaches
Authors: El-Magd Sherif Ahmed Abu , Ahmed Hanaa , Pham Quoc Bao , Linh Nguyen Thi Thuy , Anh Duong Tran , Elkhrachy Ismail , Masoud Ahmed M.
Published: December 2022

Land use and climate change always induce significant changes in various parameters of the hydrologic cycle (e.g., surface runoff, infiltration, evapotranspiration). The Wadi El-Assiuti downstream area in the Eastern Desert of Egypt is one of the most promising areas for development that is suffering from insufficient water availability and inadequate water quality for different purposes. The main goal of this research is to evaluate the changes in groundwater quality, land use, and climate in association with geology and flooding during three periods within the years 1997–2019 in the downstream portion of Wadi El-Assiuti in the Eastern Desert of Egypt, using spatiotemporal variation associated with groundwater hydrochemical analysis and GIS techniques. About 133 groundwater samples were collected to examine groundwater quality changes over time. Different groundwater quality indices were calculated, and the results show that TDS levels of groundwater in the study area ranged between 1080–2780 mg/L, 672–4564 mg/L, and 811–6084 mg/L, while SAR levels varied within 6.15–15.34, 1.83–28.87, and 1.43–30.57 for the years 1997, 2007, and 2019, respectively. Both RSBC and SSP values exhibited significantly increasing trends over time. KR values were within 1.36–4.06 in 1997, 0.58–14.09 in 2007, and 0.35–14.92 in 2019; MAR values were within 6.9–45.2 in 1997, 20.79–71.5 in 2007, and 17.71–75.81 in 2019; and PI values were within 60.16–83 in 1997, 45.56–101.03 in 2007, and 42.51–148.88 in 2019. Across the entire study area, ongoing land use changes increased from 1.1% in 1997 to 4.1% in 2019. Findings pointed to the significant contribution of the deep Nubian Sandstone Aquifer to the groundwater aquifer at Wadi El-Assiuti through fractures and deep faults. Given the climatic conditions from 1997–2019, these changes may have affected water quality in shallow aquifers, especially with increasing evaporation. Realizing the spatiotemporal variation of the aquifer recharge system, land use development, and climate change clearly would help in water resource management. This study revealed that flooding events, deep-seated geologic structures, and land use development associated with human activities have the highest impact on groundwater quality.
Uncertainty and Sensitivity Analysis of the Effective Implementation of Water Quality Improvement Programs for Citarum River, West Java, Indonesia
Authors: Juwana Iwan , Rahardyan Nur A. , Permadi Didin A. , Sutadian Arief D.
Published: December 2022

Pollution of rivers is a challenge for many countries. In the Citarum watershed, Indonesia, where pollution has been an emerging issue nationwide, many programs and policies have been set up. However, implementation of all the planned programs and the significance of their contributions toward water quality improvement of the Citarum River have not been analyzed. In this paper, we present original research on evaluating water quality programs planned to achieve outputs by using uncertainty and sensitivity analysis for a river. The essential inputs included: (1) key parameters, (2) priority planned programs, and (3) interrelationships between programs, parameters, and the level of successfulness of water quality control programs. The first and second inputs were prepared simultaneously using Principal Component Analysis (PCA) and Analytical Hierarchy Process (AHP). The latter was obtained using the Delphi method to obtain the related stakeholders’ opinions. Finally, we explore Monte Carlo simulation to analyze parameter uncertainty and sensitivity contributing to the program’s effectiveness. By implementing all the water quality control programs, the results showed that cadmium, BOD, and fecal coliform were the most affected parameters. In addition, the most effective programs to improve the pollution index were domestic waste, farming, solid waste, and water resource programs. If those programs were implemented collectively, the probability of reducing the pollution index was within a range 2.01–36.22% from the base case.
Water Temperature Evolution Driven by Solar Radiation in an Ice-Covered Lake: A Numerical Study and Observational Data
Authors: Smirnov Sergei , Smirnovsky Alexander , Zdorovennova Galina , Zdorovennov Roman , Palshin Nikolay , Novikova Iuliia , Terzhevik Arkady , Bogdanov Sergey
Published: December 2022

Until now, the phenomenon of radiatively driven convection (RDC) in ice-covered lakes has not been sufficiently studied, despite its important role in the functioning of aquatic ecosystems. There have been very few attempts to numerically simulate RDC due to the complexity of this process and the need to use powerful computing resources. The article presents the results of Large Eddy Simulations (LES) of RDC with periodic external energy pumping, which imitates the diurnal variations in solar radiation in the subglacial layer of lakes in spring. The research is aimed at numerically studying the initial stages in the formation and development of a convective mixed layer (CML). A numerical calculation was carried out for three variants of external energy pumping that differed in intensity. A diurnal acceleration and suppression of RDC due to a change in external pumping was revealed for all three variants. The results of numerical simulations provide estimates of such integral parameters of RDC development as the rate of deepening of the lower boundary of the CML, and the rate of water temperature rise within this layer. It was shown that as the cumulative heating of the CML increases over several days, daily increments in temperature and depth slowed down; that is, the dependence of the integral RDC parameters on external pumping was nonlinear. The LES results on RDC parameters were in good agreement with our observational data.
Estimating Chlorophyll-a Concentration from Hyperspectral Data Using Various Machine Learning Techniques: A Case Study at Paldang Dam, South Korea
Authors: Im GwangMuk , Lee Dohyun , Lee Sanghun , Lee Jongsu , Lee Sungjong , Park Jungsu , Heo Tae-Young
Published: December 2022

Algal blooms have been observed worldwide and have had a serious impact on industries that use water resources, which is a problem for people and the environment. For this reason, an algae warning system is used to count the number of cyanobacterial cells and the concentration of chlorophyll-a. Several studies using multispectral or hyperspectral data to estimate chlorophyll concentration have recently been carried out. In the present study, a comparative approach was applied to estimate the concentration of chlorophyll-a at Paldang Dam, South Korea using hyperspectral data. We developed a framework for estimating chlorophyll-a using dimension reduction methods, such as principal component analysis and partial least squares, and various machine learning algorithms. We analyzed hyperspectral data collected during a field survey to locate peaks in the chlorophyll-a spectrum. The framework that used support vector regression achieved the highest R2 of 0.99, a mean square error (MSE) of 1.299 μg/cm3, and showed a small discrepancy between observed and real values relative to other frameworks. These findings suggest that by combining hyperspectral data with dimension reduction and a machine learning algorithm, it is possible to provide an accurate estimation of chlorophyll-a. Using this, chlorophyll-a can be obtained in real time through hyperspectral sensor data input from drones or unmanned aerial vehicles using the learned machine learning algorithm.
La cathédrale et son quartier : problèmes de topographie dans les cités méridionales
Authors: Esquieu Yves
Published: December 2022

La situation et l’expression topographique du quartier de la cathédrale dans les villes s’avèrent éminemment variables dans le Midi de la France. Le seul enclos canonial et épiscopal qui soit fortifié de manière précoce est celui de Viviers. Bien des quartiers cathédraux implantés à la périphérie urbaine ne le sont qu’au XIIe siècle, en raison de leur position. La cathédrale se dresse parfois au centre du quartier canonial ; d’autres fois, elle ouvre plus directement sur la ville (ainsi à Carpentras et Arles). Souvent, il n’existe pas de quartier bien individualisé, sans qu’on puisse affirmer qu’il n’y a pas eu de clôture dans des temps plus anciens (Valence, Aix, Fréjus, Cavaillon et Narbonne, par exemple). La variété des cas procède, semble-t-il, des conditions historiques locales.
L’ordre des Prêcheurs dans l’iconographie méridionale et ses modes de représentation
Authors: Russo Daniel
Published: December 2022

The Order of Preachers in Southern French Iconography and its Modes of Representation.

Dominican memory partly rests on an iconographie tradition formed after 1250, when the Order somewhat moved away from the ascetic path of its beginnings. From the second half of the 13th century on, figurative representations spread in monasteries. Their role was to convey the Preachers’ community and the life it intended to lead by praising the Order’s apostolic mission within Church. In the 14th century, the Order felt it was and showed itself as, particularly through Saint Thomas, the guardian of divine word ; it introduced itself as successor of the apostles and thus on the same level as bishops. In the 15th century, the Preachers’ past, as portrayed, eventually identified itself with the past of Christianity, with a strong emphasis on the repression of heresies. The representation of Saint Dominic then became a very common topic again when Observance was established, as guarantee of reform and rebuilding. Yet, even if the Order of Preachers recognized itself in the saints it honoured, it did not arouse the people’s devotion and, in Dominican monasteries themselves, most of the chapels and churches bore the names of traditional intercessors.
Les offices des saints patrons provençaux : apports de la musicologie à l'histoire ecclésiastique d’Arles et Marseille (Xe-XIVe siècle)
Authors: Goudesenne Jean-François
Published: December 2022

The cult of the saints had natural consequences on liturgical issues. An antiphonary and breviary, dating from the 13th and 14th centuries and that were used in Arles and Marseille, make it possible to study the liturgical cult which had grown out of hagiographie texts. Among the celebrations peculiar to western Provence dioceses are Victor’s, Jean Cassien’s, Marthe’s, Satumin’s, Lazare’s and Trophime’s. The presence of a whole office of Saint Victor shows the prominence of the abbey of Marseille, head of the order. Musicological analysis places the putting together of the corpus in the 10th century at the earliest, or even after the year 1000. It takes part in the great ecclesiastical revival of the 1 1th century, when Saint Victor was spreading Gregory’s reformation. The close relations between Saint Saturnin’ s and Saint Trophime’s offices, and the glorification of the latter’s apostolic character, seem to depend on the old claim of the city of Arles to the title of Primate of Gaul. Saint Trophime’s office remains nonetheless limited to the city of Arles and the saints from Marseille prevail, even in Arles.
Caritas ou paupertas. Jean XXII et la sainteté du frère Martin Donadieu
Authors: Friedlander Alan
Published: December 2022

At the beginning of his papacy, John XXII proposed the canonization of Martin Donadieu of Carcassonne. He had known personally and admired this obscure individual, a simple friar of the dominican order. He upheld fr. Martin’s virtues as a model for the conduct of a holy life. Yet that model seems incongruously at odds with the principles that motivated the pope’s policies, especially his attitude toward the mendicant orders. Fr. Martin presented himself particularly as an adept of apostolic poverty. His virtues appear precisely those John denounced as vice. Is it necessary perhaps to rethink the ideals of John XXII ? Rather, the virtues he found in the life of Martin Donadieu did profoundly reflect a model he wished to promote for the life of Christian sanctity. Two overarching themes dominate Martin’s biography, as written by Bernard Gui : order, and benevolence (caritas). This latter ideal has not been noted as a guiding precept in the acts of John XXII. It appears, nevertheless, even in his strictest commandments. He exalted it in his bulls. He proclaimed it in his advocacy of the sainthood of Louis of Toulouse. Above and beyond the sacramentum paupertatis, he upheld the sacramentum caritatis. He observed this living virtue displayed by Martin Donadieu. In his promotion of Martin’s sanctity, John XXII, perhaps, revealed an essential vision that animated his thought at a critical moment in Church history.
Des Églises cathares en Italie ? Pour une étude critique des sources italiennes
Authors: Trivellone Alessia
Published: December 2022

Les neuf traités antihérétiques rédigés en Italie septentrionale au cours du XIIIe siècle constituent les sources principales sur lesquelles se fonde l’idée d’une présence d’ «Églises cathares » en Italie du Nord à cette époque. Après avoir présenté ce corpus, la première partie de cet article pointe les nombreuses difficultés concernant l’attribution et la datation de certains traités, ainsi que les interpolations et les modifications qu’ils ont subies dès le XIIIe siècle. La deuxième partie est spécifiquement consacrée aux traités écrits par des inquisiteurs qui prétendent retracer l’histoire et le fonctionnement des Églises cathares, jusqu’à présent pris au pied de la lettre par l’écrasante majorité des historiens. Or, l’analyse des discours montre que ces récits sont truffés de lieux communs et ont un caractère largement caricatural ; les noms d’hérétiques et les toponymes souffrent d’une telle indétermination qu’ils ne peuvent être vérifiés par recoupement avec des sources indépendantes. Il en résulte que les cathares italiens semblent bien relever d’une construction discursive et que leur existence en Italie septentrionale au XIIIe siècle doit être remise en cause.
Retour sur le « concile de Saint-Félix »
Authors: Biget Jean-Louis
Published: December 2022

Dès 1654, Guillaume Besse, avocat de Carcassonne, fait état d’une «charte » que lui aurait remise Pierre de Caseneuve, prébendier de la cathédrale de Toulouse. Cette «charte » fait état de la venue en Lauragais, l’année 1167, d’un dignitaire hérétique oriental, sous l’autorité duquel se sont rassemblées les Églises hérétiques de France, d’Occitanie et de Lombardie. Le récit du «catharisme » occitan repose, pour une large part, sur ce document tardif, depuis sa publication en 1660. Or, d’une part, cette «charte » s’avère en totale discordance avec ce que l’on sait de la dissidence occitane à la date de 1167 ; d’autre part, on y discerne l’écho des préoccupations du XVIIe siècle occitan : problème de l’établissement de la frontière franco-espagnole, question du protestantisme. Il faut en conclure qu’elle est un faux élaboré par Pierre de Caseneuve, savant de bon niveau, puis complété par Guillaume Besse, qui en fait la métaphore du danger protestant, afin d’obtenir la protection de la famille Fouquet et du parti dévot.
Trust And Governance in a Rethinking of Classical Knowledge Management Paradigms: Toolkits for Public Sector During the COVID-19 Emergency
Authors: Antonucci Gianluca , Berardi Marco , Ziruolo Andrea , Fontana Fabrizia
Published: December 2022

The post Covid-19 world is characterized by new technologies and a smart city approach. For this reason, the public sector must shift from the classic paradigms to a new way, following a Knowledge Management (KM) approach, to perform its role in dealing with emergency situations.  Starting from classical KM models, we conducted a regional case study, showing how the process of rethinking is boosted by citizens’ needs and pushed by the trust of the stakeholders in the central authority. In fact, as highlighted by part of the international literature, local authorities’ planning aims to achieve public value and alignment between stakeholders and policy making represents one of the main goals to be achieved. With an OLS regression we estimated the correlation between the trust of citizens and the statutory actions taken by central and peripheral government, showing that only with the alignment of public policies and the will of the citizens is it possible to overcome a crisis. Moreover, we underline the gaps in the literature and the missing links, with the aim of creating a KM model that can also be applied in the near future.
Upaya guru pendidikan agama islam dalam membentuk sikap religius siswa di dta al-idrus
Authors: N. Ananda Bunga M. D. , Ridha Nurjannah  , Ghina Agniya S.  , Imam Tabroni
Published: December 2022

Rusaknya moral dan etika di kalangan remaja menjadi sebuah masalah besar dalam dunia pendidikan. Sehingga penanaman nilai religius merupakan salah satu upayan yang harus dilakukan oleh seorang pendidik sebagai suatu cara atau proses menanamkan nilai yang bersumber dari ajaran agama Islam yang dianut seseorang yang di aplikasikan dalam kehidupan sehari-hari yang pada dasarnya memiliki tujuan yakni agar seseorang maupun siswa dalam kehidupan sehari-harinya tidak terlepas dari pengalaman agama, berahlak mulia, berkeperibadian luhur dan berwatak sesuai ajaran Islam. Kegiatan keagamaan yang dilaksanakan di sekolah adalah segala aktivitas sehari-hari, perbuatan maupun perkataan yang di dasarkan pada nilai-nilai serta norma agama Islam yang berpangkal pada ajaran-ajaran Islam maupun bentuk segala kegiatan yang terencana dan terkendali berhubungan dengan usaha untuk menanamkan bahkan menyebarluaskan nilai-nilai keagamaan dalam tahap pelaksanaanya dapat dilakukan orang perorangan atau kelompok di lingkungan sekolah. Pentingnya penelitian ini mengetahui dan menganalisis Bagaimana upaya guru pendidikan agama Islam di tingkat pendidikan awal (DTA) dalam membentuk sikap religius siswa. Metode penelitian menggunakan metode kualitatif deskriptif yakni penulis melihat secara langsung kejadian yang ada di lapangan, dimana penulis mnggambarkan upaya guru pendidikan agama islam dalam membentuk sikap religius siswa. Dalam penelitian kualitatif deskriptif data yang diambil oleh peneliti berupa fakta-fakta, catatan-catatan yang benar-benar terjadi di tempat penelitian. Dengan menggunakan teknik pengumpulan data meliputi observasi, wawancara, serta dokumentasi. Hasil penelitian adalah upaya guru penddikan agama Islam di DTA. Al-Idrus dalam membentuk sikap religius siswa/i dengan metode pembelajaran akhlak melalui pendidikan secara langsung, pendidikan secara tidak langsung, dan mengambil manfaat dan kecendrungan dan pembawaan anak-anak dalam rangka pendidikan akhlak.
PELAKSANAAN SENAM OTAK PADA WANITA POST MENOPAUSE KERJASAMA DENGAN PUSKESMAS JUANDA
Authors: Rusli Herdin
Published: December 2022

Abstrak: Kelurahan Air Hitam, Samarinda Ulu merupakan daerah di Kalimantan Timur  dengan jumlah fisioterapis di samarinda leih dari 10 orang. post menopause usia 65 tahun terjadi penurunan produksi hormon estrogen sehingga mengakibatkan penurunan kadar neurotransmiter yang berperan dalam fungsi ingatan yaitu asetilkolin, glutamat, neurotrophic, dan endorfin yang berada di otak.  senam otak dapat memperlancar aliran darah dan oksigen ke otak, serta meningkatkan daya ingat dan konsentrasi . Metode yang digunakan adalah demonstrasi dan membimbing wanita post menopause untuk melakukansenam otak,mengedukasi dan menasehati penderita untuk meningkatkan aktivitas fisik. Hasil yang dicapai adalah senam otak yang mana selain tubuh tetap sehat tp juga bisa menjaga an menyeimbangkan otak kanan dan kiri sehingga masalah penurunan daya ingat yang sebagian besar terjadi pada ibu-ibu yang sudah menopause dapat teratasi.
BAKTI SOSIAL PELAYANAN FISIOTERAPI PADA EVENT LARI MARATHON
Authors: Akbar Muhammad
Published: December 2022

Abtrak : Olahraga adalah proses sistematik yang berupa segala kegiatan atau usaha yang dapat mendorong, mengembangkan, dan membina potensi-potensi jasmaniah dan rohaniah seseorang dalam bentuk permainan dan perlombaan(WHO, 2011). Tercapainya prestasi olahraga merupakan usaha yang dapat diperhitungkan secara matang melalui pembinaan dini, penguasaan kemampuan teknik, taktik dan strategi serta melalui berbagai pendekatan. Beberapa tahun terakhir olahraga sudah mulai menjadi gaya hidup bagi sebagian orang atau kelompok. Terutama olahraga lari marathon yang sekarang sedang menjadi trend di masyarakat Indonesia terutama di wilayah perkotaan. Hal ini ditandai dengan mulai banyaknya event-event lari marathon berstandar nasional maupun internasional. Lari marathon dalam atletik merupakan nomor yang sangat populer. Tidak seperti nomor atletik yang lain, karena nomor yang satu ini dapat dilombakan dengan jumlah peserta banyak, bahkan bisa dalam hitungan ribuan peserta. Jarak baku dari nomor lari marathon adalah jarak pendek 10 km, jarak menengah 21 km, dan jarak penuh 42 km (Margono, 2006).