bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategic Planning for Enhanced Healthcare Access in Macau: Focus on Medical Development and Resources
Authors: Cheang Chonin , Chan Wengtong , Zhao Suning
Published: November 2024

This chapter provides a comprehensive analysis of strategic planning for enhanced healthcare access in Macau, focusing on medical development and resource optimization. It highlights the challenges and advancements in Macau’s healthcare system, including restructuring, human resource development, and integration within the Guangdong-Hong Kong-Macao Greater Bay Area (GBA). Additionally, the chapter delves into the significant growth of the Traditional Chinese Medicine (TCM) industry, underpinned by robust legislative frameworks, academic achievements, and industrial collaborations. By examining Macau’s healthcare policies, inter-regional cooperation, and innovative health solutions, this study aims to offer insights into creating a sustainable, high-quality healthcare system that addresses both current needs and future demands.
Technical-Scientific Scenario Based on the Triple Helix: Innovative Approach beyond Bibliometrics
Authors: José de Oliveira Otávio , Baptista Torres da Rocha Aglaé , Carolina Ferreira Costa Ana , Espuny Maximilian
Published: November 2024

In scientific research, obtaining reliable information, ideally from several sources of evidence, is crucial for a comprehensive understanding of the subject under study. This chapter introduces guidelines for creating the Technical-Scientific Scenario (T-SS), a valuable tool complementing traditional bibliometric studies. The T-SS incorporates the Triple Helix (TH) model, analyzing industry, government, and academia contributions and their interactions. T-SS mapping consists of collecting, interpreting, analyzing, synthesizing, and presenting information about the topic of study, which can be explored from the perspectives of the TH spheres. Its elaboration relies on the integrative review scientific method, which enables the exploration of diverse sources of evidence, such as articles, patents, organizational reports, government laws, research funding agencies, scientific projects from universities, etc. Consequently, it is possible to propose policies, strategies, and actions tailored to the TH spheres based on the T-SS, thereby contributing to the development or enhancement of the field of study.
Investigating the Effect of COVID-19 Vaccination on the Course of Disease and Recurrence of Attacks in Patients with Multiple Sclerosis
Authors: Poursaleh Samira , Dehghan Nayeri Nahid , Khatami Farnaz , Bakhshi Atieh , Ebadati Nakhjiri Nasim , Shafiee Sabet Mahdi
Published: November 2024

Background: The COVID-19 pandemic, with its high mortality rate, has underscored the urgent need for the rapid production of vaccines. This has prompted research into the effects of vaccines on specific populations, including patients with immune diseases such as multiple sclerosis (MS). Objectives: This study aimed to examine the impacts of COVID vaccination on individuals with MS. Methods: A retrospective cohort study was conducted involving 302 patients with relapsing-remitting MS who had received the coronavirus vaccine. These patients were referred to the MS clinic of two referral hospitals affiliated with Tehran University of Medical Sciences. The data collection instrument used was a checklist that included demographic information and disease-related details, such as the duration of the disease, underlying conditions, type and timing of vaccine administration, and the occurrence of attacks before and after the vaccination rounds. Results: During the first and second rounds of vaccination, the majority of patients (90.7% and 87.1%, respectively) received the Sinopharm vaccine. In the third round, approximately one-third (32.8%) did not receive the vaccine, and in the fourth round, the majority of individuals (85.8%) also did not receive it. However, most vaccinated individuals had received the Sinopharm vaccine. Among the sample, 34 individuals (11.3%) were newly diagnosed with MS after receiving the vaccine. Additionally, 41.7% of individuals experienced an attack within three months after receiving one of the vaccine doses. Conclusions: Vaccinations during the COVID era have significantly contributed to saving lives and preventing death. However, they have also had consequences that need careful examination and consideration in future vaccine production and epidemic management. The results obtained from this study can be associated with the vaccine, but given the retrospective nature of the study, further research on the long-term effects of the vaccine is needed to generalize the findings.
Flashcards del manual de preparación curso
Authors:   Doctor RE, Ruiz Espinoza Jorge
Published: November 2024

Tarjetas rapidas para el curso ENARM - DR.RE
Modern Kamu Yönetimi İçerisinde Bir Kavram: İyi İdare
Authors: Çiçek Deniz , Arslaner Hakan
Published: November 2024

Hukuk devletini benimsemiş ülkelerde, son yıllarda özel işletmelerdeki yönetim sistemlerinde yaşanan değişimlerin de etkisiyle kamu sektöründe yönetim anlayışında ciddi değişimler olmaktadır. 20. Yüzyılın sonlarında ivme kazanan teknolojinin gelişimi, ekonomilerdeki muazzam büyümeler, toplumların yönetim sistemlerine bakış açısı, ülkeler için bu değişimi aslında bir anlamda da zorunlu kılmaktadır. Kamu yönetimi algısında oluşan bu değişimin temel taşları “yönetişim” ve “iyi idare” kavramları içerisinde yer almaktadır. Demokrasiye ve insan haklarına daha saygılı olan ülkelerde bu kavramların kamu yönetim anlayışında hukuksal olarak ve uygulamada daha hızlı gelişim gösterdiği söylenebilir. Biz bu çalışmamızda “iyi idare” kavramının dünyada, özellikle de Avrupa Birliği ve O’na üye devletlerde hangi hukuk kuralları ile kabul edildiği, OECD’nin tavsiye niteliğindeki iyi idare ilkelerinin neler olduğu, öğretide bu kavramın ve bu kavramın içini dolduran temel ilkelerin önemi üzerinde duracağız. Makale, kamu yönetiminin her bir birimi için uygulanabilecek olan iyi idarenin kavramsal olarak açıklanması ve iyi idarenin getirmiş olduğu ilkelerin neleri içerdiğinin, ulusal ve uluslararası literatürden yararlanılarak, tespitini amaçlayan teorik bir çalışma zemini üzerine oturtulmuştur. Bu anlamda, çalışmanın öğretiye ciddi bir katkı sağlayacağı ve yapılacak ampirik çalışmalardaki literatür ihtiyacını da gideceği düşünülmektedir.
Non-concentric single-mode optical fiber dispersion
Authors: Saktioto Saktioto , Basdyo Doni , Zairmi Yoli , Hairi Haryana , Fadhali Mohamed , Yupapin Preecha
Published: November 2024

The application of wave transmission in telecommunication optical fiber still has problems in the form of dispersion. For this reason, it is necessary to design and operate optical fiber dispersion that is shifted or not concentric with simulation as the first step in designing which is easier, cheaper and has a high level of accuracy. The purpose of this study was to analyze the design and operation of the displaced optical fiber dispersion and determine the wavelength value at the minimum dispersion value using OptiFiber software. The input parameters consist of the refractive index of the optical fiber in the range of 1.4615 to 1.44692 and the wavelength range of 1.4 µm to 1.5 µm. The dispersion result obtained is a minimum wavelength of 1.5506 µm. This result is close to the theoretical value of 1.55 µm with attenuation and dispersion at one wavelength point. The results of this study can be used for validation in experiments.
CfP: graduate conference “Future Nostalgia and Present Utopia: Reimaging Futurism in Film and New Media”. September 23-24, 2023 @ online. Deadline: July 20, 2023.
Authors:   CSTonline
Published: November 2024

Future Nostalgia and Present Utopia: Reimaging Futurism in Film and New Media

Program in Film and Media Studies at the University of Pittsburgh

Keynote Speaker: Diana Flores Ruíz

Date: September 23-24

The University of Pittsburgh Film and Media Studies Program is pleased to announce “Future Nostalgia and Present Utopia: Reimaging Futurism in Film and New Media,” its twelfth
RACIALIZATION WITHOUT INTEGRATION: THE FIGHT FOR NBC DIVERSITY IN THE 1940S AND 1950S
Authors: Hunter Leah P.
Published: November 2024

Reviewing methods used by earlier generations to challenge discriminatory acts in television hiring practices provides proof of the long-standing battle between those who worked to challenge barriers to entry for Black people and the already established media companies that are more concerned about profit margins.
Can Groundhogs Swim?
Authors: Frey Erzsebet
Published: November 2024

Groundhogs, also known as woodchucks, are a type of rodent that belongs to the marmot family. They are found in North America, primarily in the eastern and central parts of the continent. Groundhogs are known for their burrowing behavior, as they dig extensive tunnels and burrows underground that can reach up to several meters in length. They are primarily herbivores, feeding on a diet of grasses, plants, and occasionally insects.
TV DICTIONARY – “WHAT WAS THAT MIDDLE BIT ALL ABOUT?” ON THE GOOD LIFE, SPLIT SCREEN, AND THE INCORPORATION OF DVD EXTRAS
Authors: Martin-Jones David
Published: November 2024

Creating the video essay on

The Good Life

for the TV Dictionary – the entry was “see under lifestyle(s)” – was enjoyable. The hardest part was figuring out how to condense so much visually-arresting and often humorous material into a short space of time. Well, that and the way in which the nostalgic pleasures of rewatching this iconic show from the 1970s were often tempered by the realization of the nature of some of the content.
CfP: edited collection “Different Forms of Feminism in English Language TV Series: Legacy and Resistance in Different Types of Methodology of Discourse Analysis of Female Identity”. Deadline: July 10, 2023.
Authors:   CSTonline
Published: November 2024

Over the past few decades we have seen a sharp rise in the number of central female characters in TV series, offering a wide palette of complex female identities, characters following very diverse narrative journeys.
CfP: edited collection “Urban Myths and Cultural Geography of Horror”. Deadline: Nov 15, 2023.
Authors:   CSTonline
Published: November 2024

Edited by Irena Jurković, Marko Lukić and Tijana Parezanović

Urban myths and legends continuously serve as a source of fascination and creative inspiration in anglophone cultures, especially in the context of horror genre, within which they have a specific way of articulating collective fears and fascination with the unknown.
Animals that start with I | I for animal
Authors: Frey Erzsebet
Published: November 2024

Animals that start with the letter “I” include a diverse range of creatures from different taxonomic groups, such as mammals, birds, reptiles, and insects. Some well-known examples include the Indian Elephant, Iguana, Impala, and Indochinese Tiger. Other animals that start with “I” may be less familiar, such as the Inland Bearded Dragon, Ili Pika, and Iberian Lynx.
CfP: international conference “Media Industries”. April 16-19, 2024 @ King’s College, London (UK). Deadline: Sept 15, 2023.
Authors:   CSTonline
Published: November 2024

Hosted by the Department of Culture, Media and Creative Industries, King’s College London Paper, panel, and roundtable proposals are now invited for the 2024 ‘Media Industries’ conference (‘MI2024’). After the success in 2018 of the inaugural conference ‘Media Industries: Current Debates and Future Directions’, unfortunately the planned 2020 conference had to be cancelled due to Covid lockdowns.
CfP: edited collection “Screen Storytellers: The Works of Steven Moffat”. Deadline: June 30, 2023
Authors:   CSTonline
Published: November 2024

Call for Abstracts/Proposals for Essays for an Edited Collection SCREEN STORYTELLERS: The Works of Steven Moffat Edited by William Rabkin This edited volume on the works of Steven Moffat will be the second book in a new series to be published by Bloomsbury Academic.
10 Animals With No Teeth
Authors: Frey Erzsebet
Published: November 2024

Are you fascinated by the incredible diversity of animal adaptations? Have you ever wondered how creatures survive without teeth? In this article, we’ll explore the ingenious ways 10 toothless animals have adapted to their toothless existence. From giant anteaters slurping up insects with their long tongues to scorpions relying on venomous stingers, these creatures have found alternative solutions for survival.
CfP: Special Issue of Convergence “Streaming Diversity? On and off-screen diversity in an era of automated media culture”. Deadline: September 22, 2023.
Authors:   CSTonline
Published: November 2024

Abstracts due 22 Sept 2023 Special Issue of Convergence: The International Journal of Research Into New Media Technologies Guest editors: Dr Maura Edmond, Dr Olivia Khoo, Dr Claire Perkins and Dr Verity Trott, from @Gender&MediaLab in the School of Media, Film and Journalism at Monash University, Australia.
TODAY’S TEEN DRAMAS ARE PAINTING A COLOURFUL PORTRAIT OF YOUTH
Authors: Rynord Ji Qi Lam and Caroline Maria
Published: November 2024

The research project ‘Reaching Young Audiences: Serial Fiction and Cross-Media Storyworlds for Children and Young Audiences’ (RYA) seeks to provide detailed knowledge about the production and reception of film, TV and online fiction for children, tweens and teens through in-depth analysis of the current strategies for creating engaging fiction for young audiences and extensive qualitative case studies of their media use.
’THOUGHTFUL CHAOS’: EVALUATION AND THE BEAR’S ‘PERFECT’ TV STORYTELLING
Authors: Lahm Sarah
Published: November 2024

This blog post has been sparked by the exorbitant amount of video recommendations that YouTube has offered up to me during the last few weeks after I finished season 2 of

The Bear

(Hulu, 2022—). In these various video essays (see list below), content creators talk about why

The Bear

is such a ‘perfect’ show or why certain episodes of

The Bear

are ‘perfect’ episodes.
AIN’T THAT A SHAME?: GUILT (BBC SCOTLAND, 2019-2023)
Authors: Beattie Melissa
Published: November 2024

Two very different brothers from Edinburgh (okay, Leith) are driving one night and accidentally hit a pedestrian.  What follows in the BBC Scotland series

Guilt

(2019-2023) is, unsurprisingly, more about the emotion than the legal definition of guilt as we see the crimes being committed and know that the brothers are guilty of it and the subsequent cover-up.
‘I THINK ABOUT WAR … AND ROBLOX’: TRYING TO UNDERSTAND CHILDREN AND THEIR MEDIA USE ONE REPORT AT A TIME …
Authors: Redvall Eva Novrup
Published: November 2024

Next week The Children’s Media Conference gathers people working with developing, producing and distributing content to children for a three-day programme in Sheffield. The conference is in its 20th edition in 2023, and the varied programme illustrates how all platforms are now in play when thinking about children’s media.
Appraising correlation between material requirements planning system and sustainable development: A study of north oil company, Iraq
Authors: Dawoud Haider Sultan , Suleima Abdullah Muhammad , Khazeal Baser Khalaf , Hafez Mohamed Ahmed , Ebekozien Andrew
Published: November 2024

Studies have shown that material requirements planning systems are critical to organisations’ performance and the balance of sustainability. It would translate to schedule production and deliver the right environmentally friendly products. However, there is a paucity of studies regarding material requirements planning systems and their role in enhancing environmentally friendly products in developing countries such as Iraq. This study appraises the correlation between the material requirements planning system and sustainability development to enhance efficiency in North Oil Company, Iraq. To address the study’s objectives, the researchers developed a hypothetical scheme to express the assumed relationship between the research variables and hypotheses tested. The study adopted a questionnaire survey for the data collection and 40 questionnaires retrieved as suitable from the North Oil Company’s employees in Iraq. The collected data were subjected to descriptive and inferential statistics. The research shows a significant correlation between material requirements planning systems and sustainability development. As part of the study’s implications, it suggests increasing the attention to all ways to enhance sustainable development in the researched company. It implies that improving efficiency and protecting the environment through unceasing improvement of processes and feedback to the organisation cannot be exaggerated.
Corporate Social Responsibility and Virtual Reality: A Synergistic Approach to Building Sustainable Brand Image
Authors: Amien Neneng Nurbaeti , Harjanti Wulandari , Arevin Ayat Taufik
Published: November 2024

This study explores the intersection of Corporate Social Responsibility (CSR) and Virtual Reality (VR) as a novel approach to fostering sustainable brand image. Utilizing a qualitative research method through literature review and library research, the paper analyzes existing frameworks and theories on CSR and their potential enhancement through immersive VR experiences. The findings indicate that CSR initiatives, when integrated with VR, offer companies a unique opportunity to engage consumers more deeply by creating interactive and impactful experiences that highlight their commitment to sustainability. VR can simulate real-world scenarios of a company’s social and environmental efforts, making these initiatives more tangible and relatable to consumers. This immersive engagement not only enhances consumer understanding of CSR efforts but also builds stronger emotional connections, which are essential for long-term brand loyalty. Additionally, the synergy between CSR and VR contributes to a more transparent and authentic brand image, as VR allows for a more compelling demonstration of CSR activities. The study concludes that this innovative approach of combining CSR with VR can significantly improve brand perception, foster consumer trust, and establish a sustainable brand image that aligns with modern consumer expectations of corporate responsibility and ethical behavior. Further research is suggested to explore the long-term effects of this integration on consumer behavior and brand equity
PENGARUH GAYA KEPEMIMPINAN DAN TUNJANGAN KINERJA TERHADAP MOTIVASI KERJA KARYAWAN DI KLINIK GIGI DENTMATE PURWAKARTA
Authors: Trianandya Frisca , Ramdhan Muhammad , Saksana Joned Ceilendra , Azzahra Sitti Aliyah
Published: November 2024

Penelitian ini bertujuan untuk menguji dan menganalisis Pengaruh Gaya Kepemimpinan dan Tunjangan Kinerja Terhadap Motivasi Kerja Karyawan di Klinik Gigi Dentmate Purwakarta. Jenis penelitian ini adalah penelitian kuantitatif. Data yang digunakan dalam penelitian adalah data primer yang diperoleh dari kuisioner yang disebarkan kepada karyawan di Klinik Gigi Dentmate Purwakarta. Jumlah sampel yang digunakan adalah sebanyak 40 responden. Data yang diperoleh dianalisis dengan menggunakan uji validitas, uji reliabilitas, uji asumsi klasik, uji regresi linier berganda, uji hipotesis dan uji koefisien dengan menggunakan program SPSS 25 (Statistic Package for the Sosial Sciences). Hasil pengujian secara parsial untuk gaya kepemimpinan berpengaruh signifikan terhadap motivasi kerja karyawan dengan nilai thitung 2,337 dan angka signifikansi 0,025. Tunjangan kinerja berpengaruh signifikan terhadap motivasi kerja karyawan dengan nilai thitung 4,128 dan angka signifikansi 0,000. Sedangkan pengujian secara simultan untuk gaya kepemimpinan dan tunjangan kinerja berpengaruh signifikan terhadap motivasi kerja karyawan di Klinik Gigi Dentmate Purwakarta dengan nilai f hitung 34,612 dan angka signifikansi 0,000.
Los objetivos de desarrollo sostenible para la creación de valor compartido en el turismo
Authors: Lacruhy Enríquez Claudia Carolin , González Torres Arturo
Published: November 2024

El propósito fue analizar los estudios sobre Objetivos de Desarrollo Sostenible y la Creación de Valor Compartido en el turismo. Se realizó una revisión sistemática de literatura en Google Académico y emerald insight. En la primera fase se obtuvieron 208 artículos, conforme a los criterios de selección, se usaron 50. Se aplicaron métodos estadísticos descriptivo e inferencial de criterios de calidad de los artículos de investigación; los resultados mostraron que el 54% de las investigaciones son de la región de América, siendo Colombia el país precursor con el 18%, y en Europa, España con el 18%. La metodología de los estudios resultó 50% cualitativos, el 55% con el objeto de estudio de empresas turísticas. Se concluye son escasas las investigaciones empíricas que muestran los avances de las empresas turísticas con relación de las variables mencionadas en los destinos turísticos.
AGRONEGÓCIO DA CARNE OVINA E CAPRINA NO BRASIL, UMA REVISÃO SOBRE PRODUÇÃO, PERSPECTIVAS E DESAFIOS
Authors: Pereira Neres Camila , Barros de Pinho Eduarda , Da Silva Brito Emily Cristine , Seixas dos Santos Jacqueline , Gomes Barros Kharenn , Dos Santos Gonçalves Rayane , Alves Ferreira Stérffane , Andrade Meireles Wendy , Rosanova Clauber
Published: November 2024

O agronegócio brasileiro inclui a crescente produção de carne ovina e caprina, impulsionada pela demanda interna e externa. Essas carnes são nutricionalmente vantajosas, com baixo teor de gordura e alta concentração de proteínas e minerais, no entanto, o consumo per capita de carne ovina e caprina é de apenas 700g por ano. A produção é diversa, envolvendo pequenos e grandes produtores, mas enfrenta desafios significativos, como a escassez de assistência técnica, a comercialização informal e a prevalência de abates clandestinos. Dessa forma, o objetivo deste estudo foi analisar a situação atual da produção de carne ovina e caprina no Brasil, identificando características, desafios e perspectivas de crescimento, visando fortalecer essa cadeia produtiva. Para melhorar a produtividade e a lucratividade, é fundamental implementar estratégias adequadas nos sistemas de criação, promovendo práticas modernas e atenção às necessidades nutricionais dos rebanhos. Iniciativas de incentivos governamentais e campanhas de estímulo ao consumo também são fundamentais para ampliar a aceitação da carne ovina e caprina na dieta brasileira.
Study of Machine Learning Techniques for the Estimation of Soil Moisture in Agriculture
Authors: Zavala Díaz Noel Alan , Olivares-Rojas Juan Carlos , Zavala Díaz Jonathan , Reyes Archundia Enrique , Téllez Anguiano Adriana del Carmen , Chávez Campos Gerardo Marx , Méndez Patiño Arturo
Published: November 2024

Soil moisture is crucial in various fields and monitoring it to guide irrigation is challenging. Machine learning has emerged as a promising tool to predict soil moisture levels accurately. This study evaluates machine learning techniques for this task, training models with meteorological variables and direct soil moisture measurements. Four machine learning algorithms were implemented, highlighting the Gradient Boosting Regressor as the most effective. In addition, a processed data set that combines meteorological and soil moisture measurements is presented, hoping it will be helpful for future research. This approach seeks to improve the compression and predictability of soil moisture, which is crucial for agricultural planning and water management in agriculture
Penyuluhan Fisioterapi Kasus Desminore dengan Memberikan Deep Breathing Exercise dan Yoga pada Komunitas Remaja di Pondok Pesantren Luhur Kota Malang.
Authors: Lala Nabilah Alfizah  , Nurul Aini Rahmawati  , Lina Sriyatun
Published: November 2024

Kalangan remaja saat ini banyak yang mengeluhkan nyeri pada saat menstruasi yang biasa disebut dengan desminore. Desminore adalah suatu kondisi seseorang mengalami nyeri dan kram perut bagian bawah yang dapat mengganggu aktivitas sehari-hari. Diperlukan pencegahan untuk mengatasi permasalahan tersebut dengan mengadakan penyuluhan mengenai desminore serta memberikan penatalaksaan fisioterapi seperti Deep Breathing Exercise dan Yoga untuk mengurangi keluhan nyeri tersebut. Penelitian dilakukan dalam bentuk penyuluhan dan edukasi yang dilakukan pada tanggal 19 Oktober 2024 pada Komunitas Remaja di Pondok Pesantren Luhur, Kota Malang yang berjumlah 50 responden. Motode yang digunakan pada penelitian ini berupa promosi kiesehatan mengenai Desminore dengan memberikan Deep Breathing Exercise dan Yoga untuk mengurangi nyeri pada saat menstruasi kepada remaja wanita. Media promosi yang digunakan yaitu poster, leaflet dan power point. Hasil penelitian menunjukan adanya peningkatan pengetahuan responden sebelum dan setelah diberikan penyuluhan mengenai Desminore.
TAFSIR TEMATIK TENTANG JUDI PADA SURAT AL-MAIDAH AYAT 90
Authors: Alfakhaera Arieni , Nasrullah Nasrullah
Published: November 2024

Penelitian ini membahas tafsir tematik mengenai perjudian yang dijelaskan dalam Surat Al-Maidah ayat 90. Ayat ini menekankan larangan terhadap tindakan judi dan minuman keras, yang dianggap sebagai perbuatan kotor dan termasuk dalam kategori syaitan. Dalam konteks ini, penelitian bertujuan untuk mengeksplorasi makna mendalam dari ayat tersebut dan implikasinya terhadap masyarakat kontemporer. Metode yang digunakan dalam penelitian ini adalah pendekatan tafsir tematik dengan mengkaji berbagai literatur tafsir klasik dan kontemporer. Hasil penelitian menunjukkan bahwa perjudian tidak hanya merugikan individu, tetapi juga berdampak negatif pada masyarakat secara keseluruhan, menciptakan konflik, ketidakadilan, dan kerugian ekonomi. Penelitian ini juga menyoroti pentingnya pemahaman nilai-nilai Islam dalam membangun masyarakat yang bebas dari praktik perjudian. Dengan demikian, hasil penelitian ini diharapkan dapat memberikan kontribusi dalam meningkatkan kesadaran masyarakat tentang bahaya perjudian dan pentingnya mengikuti ajaran agama dalam kehidupan sehari-hari.
SOLUÇÃO DE CONFLITOS E DESJUDICIALIZAÇÃO: UMA ANÁLISE ACERCA DA PLATAFORMA CONSUMIDOR.GOV.BR
Authors: Nascimento Angelia Souza do , Ruiz Gabriela Dourado , Rego Ihgor Jean
Published: November 2024

The present research proposed to identify how the use of the consumer.gov.br platform can promote the dejudicialization of consumerist laws. The theoretical discussion dealt with the concept and how the consumer.gov.br platform is used and its compatibility with the Consumer Protection Code, exposed the evolution of the national consumer protection system with the implementation of the consumer.gov platform. .br and explained about the dejudicialization of consumer laws with the use of the consumer.gov.br platform. For this, a bibliographic search was carried out, using books, scientific articles, dissertations and the consumer.gov.br platform itself on the topic addressed and for the question presented on how the consumer.gov.br platform can contribute to the judicialization. of consumer disputes, it was obtained that due to the large number of lawsuits being processed in the judiciary, all the high costs that are incurred in the judiciary machine and the long waiting time for processing the process, it was shown how much investment is needed in digital platforms that promote dejudicialization, and consum.gov.br is one of them, because there the parties can resolve disputes without the need for a judicial process, thus reducing the demands of consumerist conflicts in the Judiciary.
Avaliação da fadiga mental e de seus fatores de risco em pilotos de caça da Força Aérea Brasileira
Authors: Milioli Ferreira Diogo , FERREIRA Daniele Bittencourt , SÁ Paula Morisco de
Published: November 2024

O presente estudo visa avaliar os fatores de risco relacionados a fadiga mental em pilotos de caça da Força Aérea Brasileira e traçar o perfil dessa população. Foram analisados dados de 58 pilotos, coletados por meio da aplicação de questionário sociodemográfico, da Escala de Sentimento de Fadiga, do DASS-21, do WHOQOL BREF e do IPAQ-curto. Os principais resultados revelaram que a satisfação com o domínio social e níveis elevados de ansiedade são fatores de risco para o desenvolvimento de fadiga mental entre os pilotos (p < 0,05). Em contrapartida, a satisfação com o domínio psicológico mostrou-se um fator protetor significativo (p < 0,001). Os pilotos de caça enfrentam riscos consideráveis de fadiga mental e compreender os fatores contribuintes para esse estado é crucial para desenvolvimento de estratégias eficazes de  gerenciamento de risco de fadiga dentro desta população.
La asesoría pedagógica con profesores de educación primaria desde la mirada de los directores
Authors: Velázquez Sandoval Juana Adriana , Correa Terán José Edgar
Published: November 2024

El objetivo general del estudio es analizar los tipos de asesoría pedagógica que facilitan los directores con profesores de educación primaria, para generar trabajo colaborativo y acompañamiento en las prácticas educativas. Entre los motivos para abordar el tema de la asesoría pedagógica, destacan las indicaciones u orientaciones que marca la Secretaría de Educación Pública (SEP) en diferentes documentos normativos; sobre la importancia de la asesoría pedagógica para garantizar y brindar certeza con respecto a la calidad y excelencia de enseñanza de los profesores de educación básica; además de visualizar la función directiva como una figura relevante para propiciar diálogos horizontales y reflexivos. En la metodología de investigación, se contemplan el paradigma interpretativo, enfoque cualitativo, y, especialmente, el método biográfico narrativo; que ayudaron a sistematizar la indagación con respecto a la asesoría pedagógica en sus etapas de identificación de la problemática, diagnóstico situacional, diseño, ejecución y evaluación del plan de intervención, hasta determinar el seguimiento institucional llevado a cabo.
ATIŞTIRMALIK BESİNLERİN TUZ İÇERİKLERİ: KLİNİK KARAR VERİCİLERİN KULLANIMINA YÖNELİK VERİ TABANI OLUŞTURULMASI
Authors: Ergül Yasemin , Şahan Rabia , Çelik Mine Nur
Published: November 2024

Tuz, gıdalarda koruyucu ve tatlandırıcı olarak kullanılan temel bir bileşen olup aşırı tüketimi çeşitli sağlık sorunlarına yol açan önemli bir halk sağlığı konusudur. Bu makale atıştırmalık besinlerin tuz içeriklerini inceleyen bir saha araştırmasıyla, tüketicilerin ve sağlık profesyonellerinin bilinçlenmesi için bir veri tabanı oluşturma amacını taşımaktadır. Üç zincir market için kısa ziyaretler yapılarak ürün etiket bilgileri kaydedilerek bir veri tabanı oluşturulmuştur. Atıştırmalık besinler kuruyemişler, cips, gofret, bisküvi, çikolata, kahvaltılık atıştırmalık, kek, jelibon, sakız, şekerleme, bar, kraker olarak gruplandırılmıştır. Veriler ortalama, standart sapma, medyan, en büyük ve en küçük değerler olarak sunulmuştur. Ortalamalardan yola çıkılarak dağılımlar gösterilmiştir. Bu araştırmada; ürün isim ve tatlarından bağımsız olarak etiket okuma bilgisinin ne derece önemli olduğu ortaya konulmuştur. Uzman görüşlerine sunulan veri tabanı bir karar ağacı şeklinde de sunulmuştur. Tüketicilerin, sağlık profesyonellerinin ve besin endüstrisi çalışanlarının tuz ile ilgili aksiyona geçmeleri ve ilerleyen çalışmalar ile atıştırmalık besinlerin tuz içeriğine yönelik yazılımların geliştirilmesi önerilir.
Difficulty in artificial word learning impacts targeted memory reactivation and its underlying neural signatures
Authors: Klaassen Arndt-Lukas , Rasch Björn
Published: November 2024

Sleep associated memory consolidation and reactivation play an important role in language acquisition and learning of new words. However, it is unclear to what extent properties of word learning difficulty impact sleep associated memory reactivation. To address this gap, we investigated in 22 young healthy adults the effectiveness of auditory targeted memory reactivation (TMR) during non-rapid eye movement sleep of artificial words with easy and difficult to learn phonotactical properties. Here, we found that TMR of the easy words improved their overnight memory performance, whereas TMR of the difficult words had no effect. By comparing EEG activities after TMR presentations, we found an increase in slow wave density independent of word difficulty, whereas the spindle-band power nested during the slow wave up-states – as an assumed underlying activity of memory reactivation – was significantly higher in the easy/effective compared to the difficult/ineffective condition. Our findings indicate that word learning difficulty by phonotactics impacts the effectiveness of TMR and further emphasize the critical role of prior encoding depth in sleep associated memory reactivation.
Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth
Authors: Qin Lianhua , Xu Junfang , Chen Jianxia , Wang Sen , Zheng Ruijuan , Cui Zhenling , Liu Zhonghua , Wu Xiangyang , Wang Jie , Huang Xiaochen , Wang Zhaohui , Wang Mingqiao , Pan Rong , Kaufmann Stefan HE , Meng Xun , Zhang Lu , Sha Wei , Liu Haipeng
Published: November 2024

Deeper understanding of the crosstalk between host cells and Mycobacterium tuberculosis (Mtb) provides crucial guidelines for the rational design of novel intervention strategies against tuberculosis (TB). Mycobacteria possess a unique complex cell wall with arabinogalactan (AG) as a critical component. AG has been identified as a virulence factor of Mtb which is recognized by host galectin-9. Here, we demonstrate that galectin-9 directly inhibited mycobacterial growth through AG-binding property of carbohydrate-recognition domain 2. Furthermore, IgG antibodies with AG specificity were detected in the serum of TB patients. Based on the interaction between galectin-9 and AG, we developed a monoclonal antibody (mAb) screening assay and identified AG-specific mAbs which profoundly inhibit Mtb growth. Mechanistically, proteomic profiling and morphological characterizations revealed that AG-specific mAbs regulate AG biosynthesis, thereby inducing cell wall swelling. Thus, direct AG-binding by galectin-9 or antibodies contributes to protection against TB. Our findings pave the way for the rational design of novel immunotherapeutic strategies for TB control.
Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury
Authors: Zhao Qing , Zhu Yanjing , Ren Yilong , Zhao Lijuan , Zhao Jingwei , Yin Shuai , Ni Haofei , Zhu Rongrong , Cheng Liming , Xie Ning
Published: November 2024

Astrocytes derive from different lineages and play a critical role in neuropathic pain after spinal cord injury (SCI). Whether selective eliminating these main origins of astrocytes in lumbar enlargement could attenuate SCI-induced neuropathic pain remains unclear. Through transgenic mice injected with an adeno-associated virus vector and diphtheria toxin, astrocytes in lumbar enlargement were lineage traced, targeted and selectively eliminated. Pain-related behaviors were measured with an electronic von Frey apparatus and a cold/hot plate after SCI. RNA sequencing, bioinformatics analysis, molecular experiment and immunohistochemistry were used to explore the potential mechanisms after astrocyte elimination. Lineage tracing revealed that the resident astrocytes but not ependymal cells were the main origins of astrocytes-induced neuropathic pain. SCI induced mice to obtain significant pain symptoms and astrocyte activation in lumbar enlargement. Selective resident astrocytes elimination in lumbar enlargement could attenuate neuropathic pain and activate microglia. Interestingly, the type I interferons (IFNs) signal was significantly activated after astrocytes elimination, and the most activated Gene Ontology terms and pathways were associated with the type I IFNs signal which was mainly activated in microglia and further verified in vitro and in vivo. Furthermore, different concentrations of interferon and Stimulator of interferon genes (STING) agonist could activate the type I IFNs signal in microglia. These results elucidate that selectively eliminating resident astrocytes attenuated neuropathic pain associated with type I IFNs signal activation in microglia. Targeting type I IFNs signal is proven to be an effective strategy for neuropathic pain treatment after SCI.
Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways
Authors: Herrmannová Anna , Jelínek Jan , Pospíšilová Klára , Kerényi Farkas , Vomastek Tomáš , Watt Kathleen , Brábek Jan , Mohammad Mahabub Pasha , Wagner Susan , Topisirovic Ivan , Valášek Leoš Shivaya
Published: November 2024

Protein synthesis plays a major role in homeostasis and when dysregulated leads to various pathologies including cancer. To this end, imbalanced expression of eukaryotic translation initiation factors (eIFs) is not only a consequence but also a driver of neoplastic growth. eIF3 is the largest, multi-subunit translation initiation complex with a modular assembly, where aberrant expression of one subunit generates only partially functional subcomplexes. To comprehensively study the effects of eIF3 remodeling, we contrasted the impact of eIF3d, eIF3e or eIF3h depletion on the translatome of HeLa cells using Ribo-seq. Depletion of eIF3d or eIF3e, but not eIF3h reduced the levels of multiple components of the MAPK signaling pathways. Surprisingly, however, depletion of all three eIF3 subunits increased MAPK/ERK pathway activity. Depletion of eIF3e and partially eIF3d also increased translation of TOP mRNAs that encode mainly ribosomal proteins and other components of the translational machinery. Moreover, alterations in eIF3 subunit stoichiometry were often associated with changes in translation of mRNAs containing short uORFs, as in the case of the proto-oncogene MDM2 and the transcription factor ATF4. Collectively, perturbations in eIF3 subunit stoichiometry exert specific effect on the translatome comprising signaling and stress-related transcripts with complex 5’ UTRs that are implicated in homeostatic adaptation to stress and cancer.
TMEM16 and OSCA/TMEM63 proteins share a conserved potential to permeate ions and phospholipids
Authors: Lowry Augustus J , Liang Pengfei , Song Mo , Wan Yuichun , Pei Zhen-Ming , Yang Huanghe , Zhang Yang
Published: November 2024

The calcium-activated TMEM16 proteins and the mechanosensitive/osmolarity-activated OSCA/TMEM63 proteins belong to the Transmembrane Channel/Scramblase (TCS) superfamily. Within the superfamily, OSCA/TMEM63 proteins, as well as TMEM16A and TMEM16B, are thought to function solely as ion channels. However, most TMEM16 members, including TMEM16F, maintain an additional function as scramblases, rapidly exchanging phospholipids between leaflets of the membrane. Although recent studies have advanced our understanding of TCS structure–function relationships, the molecular determinants of TCS ion and lipid permeation remain unclear. Here, we show that single mutations along the transmembrane helix (TM) 4/6 interface allow non-scrambling TCS members to permeate phospholipids. In particular, this study highlights the key role of TM 4 in controlling TCS ion and lipid permeation and offers novel insights into the evolution of the TCS superfamily, suggesting that, like TMEM16s, the OSCA/TMEM63 family maintains a conserved potential to permeate ions and phospholipids.
Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2
Authors: Yang Guangyan , Xiang Jiaqing , Yang Xiaoxiao , Liu Xiaomai , Li Yanchun , Li Lixing , Kang Lin , Liang Zhen , Yang Shu
Published: November 2024

TGF-β stimulates CCN2 expression which in turn amplifies TGF-β signaling. This process promotes extracellular matrix production and accelerates the pathological progression of fibrotic diseases. Alternative splicing plays an important role in multiple disease development, while U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential factor in the early steps of pre-mRNA splicing. However, the molecular mechanism underlying abnormal CCN2 expression upon TGF-β stimulation remains unclear. This study elucidates that SIRT4 acts as a master regulator for CCN2 expression in response to TGF-β by modulating U2AF2-mediated alternative splicing. Analyses of renal biopsy specimens from patients with CKD and mouse fibrotic kidney tissues revealed marked nuclear accumulation of SIRT4. The tubulointerstitial fibrosis was alleviated by global deletion or tubular epithelial cell (TEC)-specific knockout of Sirt4, and aggravated by adeno-associated virus-mediated SIRT4 overexpression in TECs. Furthermore, SIRT4 was found to translocate from the mitochondria to the cytoplasm through the BAX/BAK pore under TGF-β stimulation. In the cytoplasm, TGF-β activated the ERK pathway and induced the phosphorylation of SIRT4 at Ser36, which further promoted its interaction with importin α1 and subsequent nuclear translocation. In the nucleus, SIRT4 was found to deacetylate U2AF2 at K413, facilitating the splicing of CCN2 pre-mRNA to promote CCN2 protein expression. Importantly, exosomes containing anti-SIRT4 antibodies were found to effectively mitigate the UUO-induced kidney fibrosis in mice. Collectively, these findings indicated that SIRT4 plays a role in kidney fibrosis by regulating CCN2 expression via the pre-mRNA splicing.
Comprehensive empirical evaluation of feature extractors in computer vision
Authors: ISIK Murat
Published: November 2024

Feature detection and matching are fundamental components in computer vision, underpinning a broad spectrum of applications. This study offers a comprehensive evaluation of traditional feature detections and descriptors, analyzing methods such as Scale Invariant Feature Transform (SIFT), Speeded-Up Robust Features (SURF), Binary Robust Independent Elementary Features (BRIEF), Oriented FAST and Rotated BRIEF (ORB), Binary Robust Invariant Scalable Keypoints (BRISK), KAZE, Accelerated KAZE (AKAZE), Fast Retina Keypoint (FREAK), Dense and Accurate Invariant Scalable descriptor for Yale (DAISY), Features from Accelerated Segment Test (FAST), and STAR. Each feature extractor was assessed based on its architectural design and complexity, focusing on how these factors influence computational efficiency and robustness under various transformations. Utilizing the Image Matching Challenge Photo Tourism 2020 dataset, which includes over 1.5 million images, the study identifies the FAST algorithm as the most efficient detector when paired with the ORB descriptor and Brute-Force (BF) matcher, offering the fastest feature extraction and matching process. ORB is notably effective on affine-transformed and brightened images, while AKAZE excels in conditions involving blurring, fisheye distortion, image rotation, and perspective distortions. Through more than 2 million comparisons, the study highlights the feature extractors that demonstrate superior resilience across various conditions, including rotation, scaling, blurring, brightening, affine transformations, perspective distortions, fisheye distortion, and salt-and-pepper noise.
Generative named entity recognition framework for Chinese legal domain
Authors: Mao Xingliang , Jiang Jie , Zeng Yongzhe , Peng Yinan , Zhang Shichao , Li Fangfang
Published: November 2024

Named entity recognition (NER) is a crucial task in natural language processing, particularly challenging in the legal domain due to the intricate and lengthy nature of legal entities. Existing methods often struggle with accurately identifying entity boundaries and types in legal texts. To address these challenges, we propose a novel sequence-to-sequence framework designed specifically for the legal domain. This framework features an entity-type-aware module that leverages contrastive learning to enhance the prediction of entity types. Additionally, we incorporate a decoder with a copy mechanism that accurately identifies complex legal entities without the need for explicit tagging schemas. Our extensive experiments on two legal datasets show that our framework significantly outperforms state-of-the-art methods, achieving notable improvements in precision, recall, and F1 score. This demonstrates the effectiveness of our approach in improving entity recognition in legal texts, offering a promising direction for future research in legal NER.
Effect of habitual physical activity on motor performance and prefrontal cortex activity during implicit motor learning
Authors: Tan Fu-Miao , Teo Wei-Peng , Leuk Jessie Siew-Pin , Goodwill Alicia M.
Published: November 2024

Background

Acute bouts of exercise have been shown to improve motor learning. However, whether these benefits can be observed from habitual physical activity (PA) levels remains unclear and has important implications around PA guidelines to promote motor learning across the lifespan. This study investigated the effect of habitual PA levels on brain activity within the dorsolateral prefrontal cortex (DLPFC) during procedural motor skill acquisition.

Methods

Twenty-six right-handed healthy young adults had physical activity levels quantified by calculating the metabolic equivalent of task (METs) in minutes per week, derived from the International Physical Activity Questionnaire (IPAQ). Functional near-infrared spectroscopy (fNIRS) over the DLPFC was recorded to measure neural activation during a serial reaction time task (SRTT). Behavioural indicators of procedural motor skill acquisition were quantified as reaction time and accuracy of correct trials during the SRTT. DLPFC activation was characterised as task-related changes in oxyhaemoglobin (∆[HbO2]).

Results

Findings showed that higher PA levels were associated with improvements in reaction time during procedural motor skill acquisition (p = 0.03). However, no significant effects of PA levels on accuracy or ∆[HbO2] during procedural motor skill acquisition were observed. These findings show that while habitual PA may promote motor performance in young adults, this is not reflected by changes in the DLPFC area of the brain.
On the expressiveness and structural properties of centrality measures
Authors:   , Salas Cornejo Jorge
Published: November 2024

Centrality measures are used as analytical tools to understand graph-based data in various contexts. They are particularly useful for detecting important agents in disease spreading, influential individuals in social networks, or political decisionmakers. This is primarily due to the diversity of measures and their potential for exploitation in theoretical analyses. However, there exists a gap in the understanding of centrality from a foundational perspective. In this thesis, we provide an in-depth study of centrality measures from two different angles. Firstly, we examine how centralities behave over trees. Due to the simple structure of trees, it is easier to analyze each centrality measure in a restricted setting. We introduce the rooting tree property and propose a framework of potential functions to characterize rooting measures. In the last two Chapters, we present a novel study of the family of subgraph-based centralities (SBMs), which serve as a general framework for developing new measures. To define an SBM, we select a set of important subgraphs relevant to a specific application. The most important vertices are then determined based on the number of important subgraphs surrounding them. Initially, we investigate the absolute and ranking expressiveness of SBMs, answering the question of when an arbitrary centrality measure can be defined as an SBM. This, in turn, allows us to compare commonly used centralities within the scope of SBMs. Finally, we conduct an experimental study of important subgraph-based measures, as well as commonly used measures, using statistical scores such as Pearson correlation, ranking distances, and similarities to identify evidence of closely related measures.