bluuebunny/crossref_metadata_2025 huggingface dataset:
ПОЛІТИЧНА АНТРОПОЛОГІЯ УКРАЇНСЬКОГО ДЕРЖАВОТВОРЕННЯ
Authors: Мельник В.
Published: July 2021

У статті вперше у вітчизня­ному історико-правовому дискурсі розкривається історіографічний та політико-правовий зміст україн­ської політичної традиції фронтиру. Позаяк політична антропологія вивчає насамперед політичні тра­диції, то фронтирність (політична, етнічна, культурна, юридична) визначена як предмет політико-ан- тропологічного дослідження. При цьому автор звертає увагу на те, що політична антропологія має вагоме теоретико-методологічне значення і для політичної науки, і для юридичної теорії держави та права (зокрема, з точки зору еліто- логії). Отже, із позицій політоло­гічного аналізу політична традиція фронтиру характеризується легі­тимацією неформальних зв'язків 

між компліментарними соціоетніч- ними групами (східні слов’яни-тюр- ки-візантійці) та імперативним психологічним        несприйняттям

некомпліментарних соціоетнічних груп (східні слов'яни-тюрки contra германці). З позицій історико-прав- ничого аналізу політична традиція фронтиру сягає корінням надання Римською/Візантійською імперією статусу «федератів» різноетніч- ним племенам Північного Причор­номор'я. Автор розглядає феномен етнокультурної                                компліментар­

ності, що з давніх часів забезпечу­вав цивілізаційну близькість східних слов'ян та тюркських кочівницьких племен. Стверджується, що тюрк­ські засади «елю», як общини «віль­них людей», вплинули на консти­туювання українських політичних традицій, заклали підвалини прита­манного українській етнічній психо­логії антиінституціоналізму, пере­дували козаччині. Підкреслюється, що політичний розвиток Київської Русі уможливився виключно завдяки творчій кооперації Східної Римської імперії (Візантії) із тюркськими племенами федератів. Прослідко- вується історія взаємин між Рим­ською / Візантійською імперією та тюркськими федератами Півден­ної України. Розкриваються ґенеза та ідеологічні конотації «київ­сько-руського міфу», «козацького міфу», «річпосполитського нара- тиву», «російської імперської істо­ріографії». Історіографічні екскурси чергуються з авторськими оцінками геополітичного і правничого змісту політичних процесів на українських теренах за часів т. зв. «Київської Русі» та «Козаччини». Артикулю- ється положення про рефлективний характер формування української національної ідентичності протя­гом XVIII-XIX ст, що цілковито співпав із постнаполеонівським творенням російської ідентичності, розвиваючись на противагу поль­ським візіям «Східних Кресів».

Засадничий висновояк статті - заклик до осмислення візантиніс- тичних і тюркських передумов фор­мування української державності як специфічно фронтирного політи- ко-юридичного феномена.
Giải pháp cảnh báo tránh va chạm dựa trên dữ liệu môi trường và đặc điểm điều khiển phương tiện.
Authors: Huỳnh Công Pháp , Quách Hải Thọ , Phạm Anh Phương
Published: July 2021

Trong quá trình chuyển động của phương tiện khi tham giao thông thìcác yếu tố cần được xét đến là các tính năng an toàn để tạo nên sự thoải mái chongười ngồi trên xe. Trong bài báo này, với việc phân tích mối quan hệ giữa thờigian tránh va chạm (TTC) kết hợp với dữ liệu thông tin môi trường, cùng với cácthông số dựa trên đặc điểm của người điều khiển phương tiện, từ đó đề xuất giảipháp mô hình cảnh báo tránh va chạm cho phương tiện. Đặc điểm của mô hìnhcảnh báo tránh va chạm này có thể thích ứng với nhiều điều kiện điều khiểnphương tiện khác nhau và đưa ra ngưỡng cảnh báo thích hợp. Kết quả mô phòngđược thực hiện trong môi trường mô phỏng Matlap để chứng minh giải pháp đềxuất hoạt động hiệu quả với những điểm tối ưu như những giảm thiểu rủi ra vachạm và cải thiện mức độ an toàn khi điều khiển phương tiện.
DESIGN AND FABRICATION OF MULTI-PURPOSE MINERAL LEACHING EQUIPMENT
Authors: Ajibola Olawale , Borisade Sunday , Adebayo Abdullahi , Owa Adebayo , Adigun Oluwole , Oni Olamide , Akanni Princess , Oni Abayomi , Omoyeni Dada , Fagbohungbe Ayodeji , Umunakwe Reginald , Kolawole Folorunsho
Published: July 2021

With much amount of money the nation had invested into the extractive sector of the economy, minerals are still mined and exported out of the country for beneficiation which results into much economic losses in the mining and extractive industries. The need to reduce the huge amount of losses expended on extracting valuable metals from ores by local miners and out springing cottage industries motivates this work. This report covers the design and construction of a laboratory size leaching equipment suitable for dissolution of clean pulverised minerals in acid and alkaline media via agitation and in-situ leaching techniques in single operation system. The dissolved metals are easily recovered from the solution by other techniques. The design and fabrication is based on the fundamentals of stoichiometric calculations and chemical reactions, engineering design drawings using AUTOCAD and INVENTOR softwares, material selection and safe environmental ethics. The equipment is produced from combination of highly corrosion resistant plastic materials, mild steel, stainless steel and other components. For the purposes laboratory studies, the machine can process about 320-350 kg mineral feeds charged manually and in batches for working period of 1 to 8 hours per day. The estimated fabrication cost is about N194,500.00.
Jesuit libraries and popular Jesuit literature in Kingdom of Hungary in the 17th century. Interconnection between Hungarian and Polish Jesuit book culture
Authors: Špániová Marta , Lichnerová Lucia
Published: July 2021

The authors present the characteristics of Jesuit libraries in the Kingdom of Hungary in terms of their content, with special focus on works by the most influential Jesuit authors, which were among the most numerous ones in Hungarian Jesuit libraries. The authors also draw attention to the most popular titles published by the Hungarian Jesuits in the 17th century, which can be considered bestsellers of Baroque Catholic literature not only in the Kingdom of Hungary, but also abroad. Many of them also found their readers in Poland and were translated into Polish. Furthermore, the authors point to the interconnection between Hungarian and Polish Jesuit book culture and the Jesuit Polonica in Hungarian Jesuit libraries and typographies of the 17th-18th century. The Hungarian book culture does not mean the book culture of contemporary Hungary, but of Kingdom of Hungary. This paper focus on the Jesuits from the Slovak territory, which was a part of Kingdom of Hungary for 800 years (from 11th century to 1918). The essential research sources are the international educational program Ratio Atque Institutio Studiorum Societatis Jesu and catalogues of Hungarian Jesuit libraries, located in Slovakia, from the years 1632–1782.
Druki braniewskie w zbiorach Biblioteki Muzeum Warmii i Mazur w Olsztynie
Authors: Łuczyńska Alicja
Published: July 2021

Oficyna wydawnicza w Braniewie funkcjonowała w latach 1589 – 1773. Jej działalność podzielić można na dwa okresy. Pierwszy to funkcjonowanie i prowadzenie jej przez kolejno sześciu typografów prywatnych: Jana Saxo, Jerzego Schönfelsa, Kacpera Weingärtnera, Piotra Freimutha, Piotra Schultza oraz Piotra Rosenbüchlera. Drugi okres to lata 1697 – 1773 kiedy oficyna zarządzana była przez Towarzystwo Jezusowe.W zbiorach Biblioteki Muzeum Warmii i Mazur w Olsztynie znajdują się 64 stare druki (w tym 68 tytułów) wydane przez ową typografię. Autorka poddała analizie 20 spośród nich. Przy opisie posłużono się kluczem chronologicznym. Wyboru dokonano dodatkowo ze względu na znaki proweniencyjne znajdujące się na woluminach. Wybrane przykłady starych druków odzwierciedlają charakter wydawniczy oficyny. Druki z kolekcji muzealnej są uzupełnieniem druków braniewskiej przechowywanych w innych bibliotekach m.in. w Bibliotece Wyższego Seminarium Duchownego Metropolii Warmińskiej „Hosianum” w Olsztynie i Bibliotece Uniwersyteckiej w Uppsali.
Archiwum Towarzystwa Naukowego im. Tarasa Szewczenki w kolekcji Zakładu Narodowego im. Ossolińskich : charakterystyka i losy zbioru
Authors: Tchaczuk Olga
Published: July 2021

Towarzystwo Naukowe im. Szewczenki to najstarsza ukraińska instytucja naukowa, która funkcjonowała we Lwowie w latach 1873-1940. Po likwidacji Towarzystwa przez władze radzieckie jego zbiory zostały rozproszone, część kolekcji podczas II wojny światowej trafiła do Polski, gdzie została podzielona między dwie instytucje: Bibliotekę Narodową w Warszawie i Ossolineum we Wrocławiu. Archiwum NTSz przechowywane w kolekcji Ossolineum to cenny zbiór dokumentów źródłowych dotyczących historii Ukrainy pierwszej połowy XX w. Mają one szczególną wartość dla badań nad historią ówczesnego ukraińskiego życia politycznego i gospodarczego, procesu literackiego oraz ruchu wydawniczego. Archiwum zawiera także ważne dokumenty, które informują o stanie stosunków polsko-ukraińskich z tego okresu. Pod koniec XX – na początku XXI w. fragmenty archiwum NTSz przechowywane w Polsce stały się obiektem polsko-ukraińskich rokowań rewindykacyjnych. Mimo że pomysł wymiany ukraińskich kolekcji przemieszczonych do Polski na pozostałe we Lwowie zbiory Ossolineum nie został ostatecznie zrealizowany, problem udało się rozwiązać dzięki kopiowaniu materiałów oraz zapewnieniu pełnego dostępu do nich obu stronom.
城市轨道交通工程建设安全风险管控措施
Authors: 何 嘉昕
Published: July 2021

随着城市化进程的加速，人口急剧增长，城市的路面交通面临着巨大的压力，部分城市陆续开展了对于轨道交通工程的建设工作。结合实际，文中从城市轨道交通工程现存的安全风险问题出发，深入探究了建设中安全管理的难点，并提出了有效控制建设安全风险的管控措施，为切实提高轨道交通的管理水平提高了参考，进一步促进城市轨道交通工程的协调、可持续性发展。
OPTIMIZATION OF QUALITY, ENVIRONMENTAL AND OCCUPATIONAL RISK BY THE SYSTEM AND TECHNOLOGICAL SOLUTIONS
Authors: Karkoszka Tatiana
Published: July 2021

The purpose of the research has been preparation of the univocal methodology of integrated risk management and usage of the system and technological solutions as a manner of quality, environmental and occupational risk optimization. The methodology used for the analysis has included a proposition of system, technological and cost aspects of integrated risk management. Particularly the methodology management should be based on the optimization of the risk and realized as the integrated operational control as well as on the monitoring of integrated system risk. Findings of the research, which have been conducted on the basis of the prepared methodology, are as follows: one of the manners of the integrated risk reduction is application of the univocal method of integrated risk estimation, which should be specific for the organization. Results of the integrated analysis should be a starting point for the minimization of the integrated risk by assuring processes continuity both on organizational and technological level. Practical implication, confirmed in the chosen production organization, can be applied in case of any organization, which wants to manage the integrated risk in the complex meaning of clients’ requirements, natural environment protection and safety conditions assurance.
Keywords: environment, integration, occupational safety, quality, risk management.
PHARMACEUTICAL MARKET AND OPPORTUNITY IN THE 21ST CENTURY FOR GENERIC DRUGS: A BRAZILIAN CASE STUDY OF OLANZAPINE
Authors: de Magalhães Jorge Lima , Quoniam Luc , Boechat Núbia
Published: July 2021

This paper aimed to identify and analyse the evolution of the generic pharmaceutical market in Brazil, specifically olanzapine drugs. For this purpose, it has been demonstrated trends through access free tools. By bibliographical survey in indexed databases as well as official data in Brazil for generic drugs and public policy, it was analyzed and performed a case study . In 2012, global pharmaceutical industry surpassed US$ 950 billion in sales with trend to reach US$ 1,2 trillion by 2016. In Brazil market has grown in its global ranking, jumped from 10th place to 7th place in five years and projection it’ll stay Top five by 2015. Brazil has significant presence in pharmerging markets by increasing US$ 10 billion/year. Generics segment accounts approximately to 20% of the total market. 2003-2011 registered a growth of 42.3%. Patents expiration in the neuroleptics area becomes more promising like a market of olanzapine in the last eight years is around US$ 120 million. After the end of the olanzapine patent (2011) sales increased 270% which demonstrate potential Brazilian market in this new century. Management problems for developing nations and undeveloped such as network management and patents analysis for health care might reveal great opportunities for investors, e.g., creation of the Big Brazilian biotechnology pharmaceutical industry.
Keywords: competitive intelligence, pharmaceutical trends, technological and innovation management.
SIGNIFICANCE OF DATABASE MARKETING IN THE PROCESS OF TARGET SEGMENTS IDENTIFICATION AND SERVICE
Authors: Łodziana-Grabowska Joanna
Published: July 2021

The study aims at presenting the position and role of marketing databases in the enterprise’s market operations and achievement of sales targets.
The study identifies the following elements pertaining to the discussed issue: essence and parts of the database marketing, significance of the database marketing in the process of target segments service, database and customer relationship management as well as the problem of the customers’ privacy in relation to their data being used and processed by market entities.
It should be emphasized that the informational systems constitute the basic elements supporting the process of sales management and service of the company’s target segments.
It should be stressed that for the trade marketing the identification of a recipient type is
of significance, which is presented in this study with reference to the database marketing. The database may also contain the information on products, departments and sales force involved in
a specific marketing action.
With such database at their disposal the companies become mobile in terms of their offer adjustment to the market requirements, while by making the customer the central point of their focus, their marketing becomes an essential and effective tool of building their relationship with the customer.
The database development in order to identify the potential customers is a significant project of impact on the efficiency of marketing and the process of target market service, both for small and large enterprises.
Keywords: customer relationship management, database marketing, direct marketing, target market.
CAUSES OF INDUSTRIAL DISPUTE: A CASE OF THE GARMENT FACTORIES AT THE ATHI-RIVER EXPORT PROCESSING ZONES IN KENYA
Authors: Nzuve Stephen N. M. , Kiilu Lucy M.
Published: July 2021

An industrial dispute may be defined as a conflict or difference of opinion between management and workers on the terms of employment (Kornhauser, Dubin and Ross, 1954). In today`s business world, competition is the order of the day. Production, quality, profits and corporate social responsibility are critical areas where companies can improve competitive edge. To attain competitive edge, companies must first ensure cooperation and harmonious relationship between all stakeholders.
The general aim of the study was to investigate the causes of industrial disputes in the garment factories in the Export Processing Zone (EPZ) Athi-River, Kenya. The study employed a descriptive research design to determine what caused the disputes and what the possible solutions were. The study population consisted of the shop stewards and human resource managers working at the four garment factories that were in operation at the time of the study. The research instrument used was a questionnaire administered to the respondents.
It was established that working conditions, pay rates, terms of employment and employee relations were the main causes of the disputes. Weak trade union movement, inefficient and inadequate social security, lack of employment benefits, opportunities for training, promotion, trained personnel at the health service, short contract and low pay are the main problems encountered by those working at the EPZ.
The study recommended that employee’s welfare and working conditions are important factors to be considered by any employer. Both supervisors and workers should work on their relationship and change attitude towards each other. The terms of employment should be looked into as many employees are unhappy with the terms of employment especially the short contracts and majority feel they are not recognized or awarded for their contribution to the organization.
On the other hand, employees need to understand clearly the company policies, rules, regulations and procedures in place. This can be initiated by management providing employee with manuals or handbooks. There should also be clear channels of communication in the organization to enhance smooth operation, understanding and enhance healthy industrial relationships.
Key words: industrial relations, industrial disputes, export processing zone, employee welfare and employee relations.
Design of Digital Based Volley Ball Basic Techniques Test Instrument
Authors: Suharta Asep , Supriadi Amir , Nurkadri Nurkadri
Published: July 2021

This study aims to design a digital-based volleyball basic technical skill test instrument using internet technology as its application. This study uses a research and development design method (Research and Development) used in this study is the Borg and Gall development model with 7 steps of potential problems, data collection, product design, product validation, design revision, product trial, product revision, trial usage, product revision, and production. This learning product was developed in the design of a digital-based volleyball basic technique test instrument. The products of this research are 1) produce a basic volleyball technical test instrument application product used in smartphones, 2) produce a villi ball basic technical instrument product that is easily accessible via the internet
Influence Ofexercise High Hurdle Jump and Forward and Lateral Hurdle Jump on Increasing Leadstrength and Power Muscle
Authors: Prilaksono Mochamad Ilham Agung , Wiriawan Oce , Wijaya Fransisca Januarumi Marhaendra
Published: July 2021

Treat sports players using a new type of exercise or a method that has been popular in the world of increasing physical abilities in recent years, namely the varied plyometric method so that athletes don't feel bored. Types of plyometric exercises high hurdle jump and forward and lateral hurdle jump are two types of plyometric exercises but their implementation is different. Therefore, it is necessary to provide learning resources and human resources who are able to provide material for plyometric training methods. This study aims to determine the effect of high hurdle jump and forward and lateral hurdle jump exercises on increasing leg muscle strength and power. This research uses a quantitative approach to the type of classroom action research. The research method uses experimental methods. The research design used the none equivalent (pretest and post-test) control group design. The independent variables in this study are high hurdle jump training, forward and lateral hurdle jump exercises, and the dependent variable is leg muscle strength and power. The sample in this study amounted to 30 students of class X who used the random sampling technique. Analysis of the data used in this study to test the effect is paired t-test. Furthermore, to test the difference in effect between the treatment and control groups was carried out using one way ANOVA on the normal data distribution. The test results showed that there was a significant difference in the high hurdle jump experimental group on the variable leg muscle strength and power with a significance value of p 0.00 <0.05, a percentage increase of 6.79% in the strength variable and 6.22% in the leg muscle power variable. There is a significant difference in the forward and lateral hurdle jump experimental group on the variable leg muscle strength and power with a significance value of p of  0.00 <0.05, a percentage increase of 6.04% in the strength variable and 7.51% in the leg muscle power variable. High hurdle jump exercises are more effective than forward and lateral hurdle jumps to increase strength and forward and lateral hurdle jumps are more effective than high hurdle jumps to increase leg muscle power.
The Characteristics of the Traditional Chinese Theather Jing Ju
Authors: Tri Utari Ismayuni  , Nanda Saputra
Published: July 2021

The title of the paper is “Characters in Jing Ju Traditional Chinese Theatre”. In This paper, the writer wants to analyze the characters from Jing Ju Traditional theatre. This paper talks about the method of the analysis which is used by the writer is descriptive comparative method. And the theory which is used in comparing and analyzed the characters and the meanings of the analysis, the writer show and describes the character which exists in Jing Ju theatre, the meaning of the mask colors from each theatre.
The role of marketing in promoting the profession of architecture: The environment of Iraqi architectural offices is a case study
Authors: Madhlom Jinan Hasan
Published: July 2021

All Marketing has a major role in professional practice, especially in architectural professing. The marketing provides a great benefit to the architect, especially if he develops this profession. Day by day, The architectural profession is becoming more competitive, as it needs to learn more about advanced marketing techniques. many architects are follow the old ways of gaining customers' reputation, and these methods do not correspond to the era of modernity in the architectural business environment and preparing competitors .So the problem surfaced(Lack of adoption of marketing as an important factor in the success of architectural offices, therefore it is necessary to search for the concept of marketing and what its plans and it’s strategies ) ,The research goal is "searching for the concept of marketing and determining what it’s plans and it’s strategies", Research hypothesis: "a successful marketing plan means getting more customers and thus more profits”. So must be three-stage approach, first: building a theoretical framework on marketing plans and strategies. Second: applying the vocabulary of the theoretical framework to an elected sample of architectural offices. Third: analyzing the results and extracting the conclusions, to conclude that there is a lack of awareness on the importance of marketing in the architectural business environment in Iraq, and the adoption of marketing as a method between offices and architectural companies to increase customers and thus increase profits.
Effect of Retrogression and Re-Aging Heat Treatment on Hardness, Tensile Strength and Microstructure of 7075 Aluminum Alloy
Authors: Al nefawy Mohamad Yehea , El dahiye Fouad
Published: July 2021

Retrogression and Re-Aging (RRA) Heat Treatment improves the tensile of aluminum alloys. In this research, to study the effect of Retrogression temperature and Retrogression time on the hardness, tensile strength and microstructure of 7075 aluminum alloy, have been applied. Retrogression treatments at different temperatures 180°C, 240°C and 370°C for 30 min and 90 min. When the retrogression temperature was 180°C for 30 min, the alloy has reached its highest hardness and tensile strength; they were respectively 165 HB and 586 MPa. RRA treatment of aluminum alloy 7075 led to precipitate a smoother, more homogeneous, and denser phase compared to the T6 treatment.
Grafting of O-Carboxymethyl Chitosan with Acrylonitrile and Studying some of its Properties and Applications
Authors: Bazat Mohamad Radawn , AL-deen Mohamad Yahay Zien , AL-Khamisy Hasan
Published: July 2021

Preparation of o-carboxymethyl Chitosan was done, wich is important derivative of chitosan. Grafting copolymerization of acrylonitrile onto o-carboxymethyl chitosan was accomplished using ammonium cerium sulfate (CAS) as an initiator. Resulting graft of o-carboxymethyl chitosan was characterized by FT-IR spectrum and DTA analysis to be compared with o-carboxymethyl chitosan. Properties such as water swelling and solubility were studied for each, whereas,. Percentage of grafting efficiency (GE%) and yield of grafting (GY%) were determined. The efficiency of grafted ocarboxymethyl chitosan (CMCh-g-PAN) to remove dyes(direct black dyes, dispersed red dyes) from industrial waste water was also determined. The results reveal good efficient absorption of black dyes more than red dyes. Efficiency from different concentrations of grafted o-carboxymethyl chitosan(CMCh-g-PAN) to reveal percentages of elimination ions from their solutions metallic ions Cu2+,Pb2+,Cd2+and Sn2+ from their solutions at room temperature with mechanical stirring for 24 hrs were also determined .It has been shown that grafted o-carboxymethyl chitosan has important role in elimination of lead ion comparing with other ions, As a result, elimination percentages of ions increase as follow: Cd2+< Sn2+< Cu2+<. Pb2+
Aplicación de MAGERIT para reducir riesgos en servicios Web en un contexto académico en Ecuador.
Authors: Jácome Segovia Diego , Castillo Fiallos Jessica , Mantilla Cabrera Carmita , Vaca Barahona Byron Ernesto
Published: July 2021

Se presenta un modelo basado en la metodología MAGERIT que permite gestionar los riesgos de seguridad informática de los servicios web de una empresa. Para este propósito se determinaron los activos de información con sus posibles amenazas y el impacto que estas tendrían si se materializaran, luego se identificó las salvaguardas de los activos y se realizó la detección de vulnerabilidades en los servicios web mediante el uso de la herramienta gratuita VEGA. Finalmente, se determinó el nivel del riesgo que a futuro permitirá al personal de tecnologías tomar mejores decisiones. En el resultado del análisis de vulnerabilidades de los servicios web se identificaron como más frecuentes: SQL Injection, PHP Error Detected y Directory Listing Detected, entre otras, con lo que al aplicar el modelo propuesto se redujo un 87.87% las vulnerabilidades altas encontradas  y se eliminaron el 12.13% de las mismas.
In the Time of Corona
Authors: Ahmed Md Sharfuddin
Published: July 2021

Abstract not available
BSMMU J 2021; 14 (COVID -19 Supplement): i
Outcome of Elderly Population Undergoing Primary PCI in a Tertiary Hospital in Bangladesh
Authors: Nasrin Sahela , Islam Shitil Ibna , Cader F Aaysha , Haq M Maksumul
Published: July 2021

Objective: To evaluate in-hospital and 1-year outcomes of primary percutaneous coronary intervention (PPCI) in elderly patients with ST-elevation myocardial infarction (STEMI).

Methods: All patients aged ≥ 65 years presenting with STEMI and undergoing PPCI at Ibrahim Cardiac Hospital & Research Institute, Bangladesh from January 2015 to August 2017 were consecutively included in the study based on predefined eligibility criteria. Data pertaining to angiographic characteristics, procedural variables, in-hospital and 1-year outcome variables were recorded and analyzed with the help of descriptive statistics and Chi-square Test.

Results: The mean age of the patients was 69.2 ± 5.2 (range: 65-85) years with male to female ratio being 4:1. The patients were predominantly diabetic (78%) followed by hypertensive (74%) and dyslipidaemic (70%) smoker (54%). Half of the patients presented with anterior myocardial infarction (MI), 30% had inferior MI, 12% with right ventricular (RV) extension and 8% with inferolateral extension. About one-quarter (24%) had arrhythmia with complete heart block (CHB). The culprit arteries were LAD (50%), followed by RCA (42%) and LCx (8%). Nearly half (46%) had single vessel disease, 34% double and 20% triple vessel disease. Majority (80%) received a single stent and 20% required two stents with mean diameter and length of the stents were 2.9 ± 0.4 mm and 27.3 ± 7.9 mm respectively. Intracoronary eptifibatide was used in 20% cases. In terms of left ventricular ejection fraction (LVEF), 58% and 28% had mild and moderate LV systolic dysfunction respectively. The mean duration of hospital stay was 4.0 ± 1.9 days. About 18% required repeat hospitalization. Overall, 7(14%) patients died (4 during their stay in the hospital due to cardiac cause and 3 during follow up due to non-cardiac causes). At 1 year follow up, in-stent restenosis was seen in 1 case followed by target vessel revascularization (TVR). The Association between age and outcome revealed that advanced age (age ≥ 75 years) was an important predictor of in-hospital and one-year outcome with Relative Risk (RR) of having unfavorable outcome was > 5-fold (95% CI: 1.6-19.5) in patients of advanced age than that in patients of age < 75 years (p = 0.008).

Conclusion: Primary PCI is a feasible treatment option for elderly Bangladeshi patients presenting with STEMI with fewer in-hospital and 1-year follow up deaths. Adverse cardiovascular events are even less. Advanced age (age ≥75 years) is an important determinant of adverse cardiovascular events including mortality, probably because of more medical co-morbidities associated with advanced age.

Ibrahim Card Med J 2020; 10 (1&2): 18-26
Implementasi E-KGB PNS Pada Pemerintah Kabupaten Asahan (Studi BKD Kabupaten Asahan)
Authors: Juliani Juliani , Efendi Bachtiar , Nofitri Rika
Published: July 2021

Abstract: Periodic salary increases are very important given to Civil Servants who have reached the group working period, which is every two years and if they have fulfilled the requirements based on laws and regulations. Regional Personnel Agency of Asahan Regency still uses word processing software, such as Microsoft Office Word to process decree of periodic salary increase. This allows delays to generate of decrees and periodic salary increases reports. In this research using UML as a system modeling language, MySQL as a database, and PHP as a programming language. The results of this research are electronic applications of periodic salary increases that can be used by staffing Information and Documentation staff easily and more efficiently to generate decrees and periodic salary increase reports. Whereas the Civil Servants can input data and upload requirement for periodic salary increases without the need to come to the Regional Personnel Agency of Asahan Regency.            Keywords: Periodic Salary Increases, Electronic Application, MySQL, PHP  Abstrak: Kenaikan gaji berkala sangat penting diberikan kepada Pegawai Negeri Sipil (PNS) yang telah mencapai masa kerja golongan yaitu setiap dua tahun sekali dan apabila telah memenuhi persyaratan berdasarkan peraturan perundang – undangan. Badan Kepegawaian Daerah (BKD) Kabupaten Asahan masih menggunakan software pengolah kata, seperti Microsoft Office Word untuk proses surat keputusan kenaikan gaji berkala. Hal ini memungkinkan terjadinya keterlambatan untuk menghasilkan surat keputusan dan laporan kenaikan gaji berkala. Dalam penelitian ini menggunakan UML sebagai bahasa pemodelan sistem, MySQL sebagai database, dan PHP sebagai bahasa pemrogramannya. Hasil dari penelitian ini adalah aplikasi elektronik kenaikan gaji berkala (E-KGB) yang dapat digunakan oleh staf Informasi dan Dokumentasi Kepegawaian dengan mudah dan lebih efisiensi untuk menghasilkan surat keputusan dan laporan kenaikan gaji berkala. Sedangkan Pegawai Negeri Sipil dapat melakukan input data dan upload syarat kenaikan gaji berkala tanpa perlu datang ke Badan Kepegawaian Daerah (BKD) Kabupaten Asahan. Kata kunci: Kenaikan Gaji Berkala, Aplikasi Elektronik, MySQL, PHP
Penilaian Kinerja Satuan Tugas Terbaik Menggunakan Metode MFEP Pada Kantor BPBD Kota Tanjungbalai
Authors: Zainuddin Zainuddin , Nofriadi Nofriadi , Marpaung Nasrun
Published: July 2021

Abstract:Duty unit office Regional Disaster Management AgencyTanjungbalai Cityhave a big taskincludes looking for, helping, and save human worried lost or face danger in natural disasters. In carrying out this great task There are also duty unit  less active,  professional, and lack of sense of responsibility in work So that it affects other co-workers. This is due to the placement of the task force not in accordance with the skills he has. Therefore, the purpose of this researchis to assist the Technical Implementation Officer of Activities in determine performance duty unit appraisal best. System development method using Multi Factor Evaluation Process (MFEP). The resulting Decision Support Systemcan make it easier Activity Technical Implementing Officer in do an assessmentduty unit performance at work environment office Regional Disaster Management AgencyTanjungbalai City. Keywords:SPK;Performance assessment;PPTK; MFEP  Abstrak:Satuan Tugas (SATGAS) Kantor Badan Penanggulangan Bencana Daerah Kota Tanjungbalai mempunyai tugas besar meliputi mencari, menolong, dan menyelamatkan jiwa manusia yang dikhawatirkan hilang atau menghadapi bahaya dalam musibah bencana alam. Dalam menjalankan tugas besar tersebut ada juga Satuan Tugas (SATGAS) yang kurang aktif,  propesional, dan kurang rasa tanggungjawab dalam bekerja, sehingga mempengaruhi rekan kerja lainnya dalam melaksanakan tugasnya. Hal ini di sebabkan penempatan satgas tidak sesuai dengan skill yang dimilikinya. Oleh karana itu tujuan dari penelitian ini adalah untuk membantu Pejabat Pelaksana Teknis Kegiatan (PPTK) dalam menantukan penilaian kinerja Satuan Tugas (SATGAS) terbaik. Metode pengembangan sistem menggunakan Multi Factor Evaluation Process (MFEP). Sistem Pendukung Keputusan yang dihasilkan dapat mempermudah Pejabat Pelaksana Teknis Kegiatan (PPTK) dalam melakukan penilaian kinerja satagas di lingkungan kerja Kantor Badan Penanggulangan Bencana Daerah Kota Tanjungbalai Kata kunci: SPK;Penilaian Kinerja;PPTK; MFEP
Técnicas nucleares y su versatilidad para la utilización y estudio de diversos procesos
Authors: Esquivel Alexander , Kodama Yasko , Villarreal José , Juri Ayub Jimena , González Guadalupe , Tejedor-Flores Nathalia
Published: July 2021

El estudio de diversos tópicos de la ciencia se efectúa haciendo uso de herramientas que muchas veces no logran la profundidad de análisis requerido para dar respuesta a situaciones que afectan el mundo en general, muchas veces son invasivos y contaminantes. Con el pasar del tiempo se ha demostrado que las técnicas nucleares son unas alternativas viables para desarrollar estudios más completos en diversos campos de la ciencia, por ejemplo: Salud, sector agropecuario, industria, medio ambiente, seguridad, entre otros. Está mesa de trabajo se organizó viendo la necesidad de informar a la sociedad sobre la otra cara de la energía nuclear y sus aportes positivos para el desarrollo de los países, para hacerlos más competitivos y amigables con el medio ambiente.
Psychological Well Being Pada Mantan Pengguna NArkoba di Kota Palembang
Authors: Ikhsan Muhamad Noor , Arisandy Desy
Published: July 2021

Abstract : This study aims to determine the psychological well being of former drug users in the city of Palembang. Factors causing well being, and psychological dynamics in former drug users in the city of Palembang, this study uses a qualitative research design and uses a case study approach to be able to find out the causes of well being and psychological dynamics of the research subjects. In this study, researchers used 7 sources, 2 people as research subjects, two people as informants knew from each subject and 2 people as informants. The results of this study found that there are factors that cause both the subject of being well that arises from within oneself (internal) and factors that arise from outside self (external).The two subjects in this study broadly have the same causative factors of being well although there are some differences in the positive emotion and engagement factors found in the study.

 

 

Keywords: Psychological well being, former drug user, Case Study Approach 

 

 

 

 

Abstrak : Penelitian ini bertujuan untuk mengetahui psychological well being pada mantan pengguna narkoba di kota palembang. Faktor penyebab well being, dan dinamika psikologis pada mantan pengguna narkoba di kota Palembang, Penelitian ini menggunakan desain penelitian kualitatif serta menggunakan pendekatan studi kasus untuk dapat mengetahui faktor penyebab well being serta dinamika psikologis dari para subjek penelitian. Dalam penelitian ini, peneliti menggunakan 7 orang sumber, 2 orang sebagai subjek penelitian, dua orang sebagai informan tahu dari masing-masing subjek dan 2 orang sebagai informan pelaku. Hasil penelitian ini menemukan  bahwa adanya faktor penyebab kedua subjek well being yang muncul dari dalam diri sendiri (internal) dan faktor yang timbul dari luar diri (eksternal). Kedua subjek di dalam penelitian ini secara garis besar memiliki faktor penyebab well being yang hampir sama walaupun terdapat beberapa perbedaan di dalam faktor positive emotion dan engagement yang ditemukan dalam penelitian.

 

Kata Kunci : Psychological well being, mantan pengguna narkoba, Pendekatan studi kasus
EFFECTIVENESS OF ONLINE LEARNING IN STKIP MUHAMMADIYAH BATANG
Authors: Adikara Fahmi Surya , Nurani Dwi Cahaya , Akhmad Yanuar , Faida Mar'atul
Published: July 2021

Wabah Corona Virus Disease (COVID-19) mengakibatkan sistem pembelajaran berubah dari pembelajaran tatap muka menjadi pembelajaran daring. Kebijakan ini dinilai tidak efisien dalam perkuliahan. Kebijakan ini dinilai akan menyulitkan mahasiswa untuk memahami materi, atau mahasiswa tidak dapat memahaminya secara optimal. Tujuan penelitian ini adalah untuk mengukur efektivitas pembelajaran daring yang dilakukan di STKIP Muhammadiyah Batang, sehingga diharapkan dapat memberikan kontribusi dan solusi dalam pembelajaran daring selama pandemi Covid-19. Penelitian ini adalah studi deskriptif kualitatif menggunakan metode survei online. Pendataan primer dalam penelitian ini dilakukan dengan mendistribusikan kuesioner secara online kepada 30 responden yang merupakan mahasiswa PGSD STKIP Muhammadiyah Batang yang terdiri dari mahasiswa semester 2 dan semester 4. Pembelajaran daring di STKIP Muhammadiyah Batang dinilai tidak efektif karena banyaknya kendala yang dialami mahasiswa. dan siswa mengharapkan pembelajaran campuran (online / tatap muka).
Bioconjugation of a Collagen-Mimicking Peptide Onto Poly(vinyl alcohol) Encourages Endothelialization While Minimizing Thrombosis
Authors: Bates Novella M. , Heidenreich Heather E. , Fallon Meghan E. , Yao Yuan , Yim Evelyn K. F. , Hinds Monica T. , Anderson Deirdre E. J.
Published: July 2021

Graphical Abstract

GRAPHICAL ABSTRACT
Chronic Wound Healing by Amniotic Membrane: TGF-β and EGF Signaling Modulation in Re-epithelialization
Authors: Ruiz-Cañada Catalina , Bernabé-García Ángel , Liarte Sergio , Rodríguez-Valiente Mónica , Nicolás Francisco José
Published: July 2021

The application of amniotic membrane (AM) on chronic wounds has proven very effective at resetting wound healing, particularly in re-epithelialization. Historically, several aspects of AM effect on wound healing have been evaluated using cell models. In keratinocytes, the presence of AM induces the activation of mitogen-activated protein (MAP) kinase and c-Jun N-terminal kinase (JNK) pathways, together with the high expression of c-Jun, an important transcription factor for the progression of the re-epithelialization tongue. In general, the levels of transforming growth factor (TGF)-β present in a wound are critical for the process of wound healing; they are elevated during the inflammation phase and remain high in some chronic wounds. Interestingly, the presence of AM, through epidermal growth factor (EGF) signaling, produces a fine-tuning of the TGF-β signaling pathway that re-conducts the stalled process of wound healing. However, the complete suppression of TGF-β signaling has proven negative for the AM stimulation of migration, suggesting that a minimal amount of TGF-β signaling is required for proper wound healing. Regarding migration machinery, AM contributes to the dynamics of focal adhesions, producing a high turnover and thus speeding up remodeling. This is clear because proteins, such as Paxillin, are activated upon treatment with AM. On top of this, AM also produces changes in the expression of Paxillin. Although we have made great progress in understanding the effects of AM on chronic wound healing, a long way is still ahead of us to fully comprehend its effects.
STYK1/NOK Promotes Metastasis and Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer by Suppressing FoxO1 Signaling
Authors: Lai Yuanyang , Lin Fang , Wang Xuejiao , Zhang Jiao , Xia Jinghua , Sun Ying , Wen Miaomiao , Li Xiaofei , Zhang Zhipei , Zhao Jinbo
Published: July 2021

Aims

Serine/threonine/tyrosine kinase 1 (STYK1) has been previously shown to have oncogenic properties, and emerging evidence suggests that STYK1 expression correlates with epithelial-mesenchymal transition (EMT). However, the mechanism of STYK1 involvement in oncogenesis remains unknown. The present study aimed to elucidate how STYK1 expression level relates to the metastasis, migration, invasion, and EMT in non-small cell lung cancer (NSCLC) and to determine the molecular mechanism of STYK1 effects.

Methods

Serine/threonine/tyrosine kinase 1 (STYK1) expression level and its relationship with the prognosis of NSCLC were determined using the ONCOMINE database and clinical cases. Non-small cell lung cancer cell lines with the overexpression or knockdown of STYK1 were established to determine whether STYK1 promotes cell migration, invasion, and EMT in vitro and in vivo. In addition, a constitutively active FoxO1 mutant (FoxO1AAA) was used to examine the role of FoxO1 in the STYK1-mediated upregulation of metastasis and EMT in NSCLC.

Results

Serine/threonine/tyrosine kinase 1 (STYK1) was upregulated in NSCLC tissues and cell lines, and its overexpression correlated with poor prognosis in patients with NSCLC after surgery. Enhanced expression of STYK1 potentiated the migration, invasion, and EMT in SW900 cells, thereby promoting metastasis, whereas knockdown of STYK1 inhibited these cellular phenomena in Calu-1 cells. Furthermore, STYK1 expression was positively related to the level of phosphorylated-FoxO1, whereas the constitutively active FoxO1 mutant protected against the positive effect of STYK1 overexpression on cell migration, invasion, and EMT.

Conclusion

Serine/threonine/tyrosine kinase 1 (STYK1) was upregulated in NSCLC and correlated with poor clinical outcomes. In addition, STYK1 suppressed FoxO1 functions, thereby promoting metastasis and EMT in NSCLC.
Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial–Mesenchymal Transition
Authors: Zou Jun , Huang Ruiyan , Chen Yanfei , Huang Xiaoping , Li Huajun , Liang Peng , Chen Shan
Published: July 2021

Background

Aerobic glycolysis and epidermal–mesenchymal transition (EMT) play key roles in the development of bladder cancer. This study aimed to investigate the function and the underlying mechanism of dihydropyrimidinase like 2 (DPYSL2) in bladder cancer progression.

Methods

The expression pattern of DPYSL2 in bladder cancer and the correlation of DPYSL2 expression with clinicopathological characteristics of bladder cancer patients were analyzed using the data from different databases and tissue microarray. Gain- and loss-of-function assays were performed to explore the role of DPYSL2 in bladder cancer progression in vitro and in mice. Proteomic analysis was performed to identify the interacting partner of DPYSL2 in bladder cancer cells.

Findings

The results showed that DPYSL2 expression was upregulated in bladder cancer tissue compared with adjacent normal bladder tissue and in more aggressive cancer stages compared with lower stages. DPYSL2 promoted malignant behavior of bladder cancer cells in vitro, as well as tumor growth and distant metastasis in mice. Mechanistically, DPYSL2 interacted with pyruvate kinase M2 (PKM2) and promoted the conversion of PKM2 tetramers to PKM2 dimers. Knockdown of PKM2 completely blocked DPYSL2-induced enhancement of the malignant behavior, glucose uptake, lactic acid production, and epithelial–mesenchymal transition in bladder cancer cells.

Interpretation

In conclusion, the results suggest that DPYSL2 promotes aerobic glycolysis and EMT in bladder cancer via PKM2, serving as a potential therapeutic target for bladder cancer treatment.
Baicalin Promotes Mammary Gland Development via Steroid-Like Activities
Authors: Chen Weizhen , Wei Wei , Yu Liya , Zhang Xin , Huang Fujing , Zheng Qiping , Wang Lingli , Cai Cheguo
Published: July 2021

Baicalin, the main flavonoid component extracted from Scutellaria roots, has a variety of biological activities and is therefore used in the treatment of many kinds of diseases. However, whether baicalin affects the normal development of tissues and organs is still unclear. Here, using a mouse mammary gland model, we investigated the effects of baicalin on the expansion of mammary stem cells (MaSCs) and mammary development, as well as breast cancer progression. Interestingly, we found that baicalin administration significantly accelerates duct elongation at puberty, and promotes alveolar development and facilitates milk secretion during pregnancy. Furthermore, self-renewal of MaSCs was significantly promoted in the presence of baicalin. Moreover, in a tumor xenograft model, baicalin promoted tumor growth of the MDA-MB-231 cell line, but suppressed tumor growth of the ZR-751 cell line. Mechanistically, baicalin can induce expression of the protein C receptor, while inhibiting the expression of the estrogen receptor. Transcriptome analysis revealed that baicalin is involved in signaling pathways related to mammary gland development, immune response, and cell cycle control. Taken together, our results from comprehensive investigation of the biological activity of baicalin provide a theoretical basis for its rational clinical application.
TRPV1 Antagonist Prevents Neonatal Sevoflurane-Induced Synaptic Abnormality and Cognitive Impairment in Mice Through Regulating the Src/Cofilin Signaling Pathway
Authors: Liu Yuqiang , Yang Han , Fu Yifei , Pan Zhenglong , Qiu Fang , Xu Yanwen , Yang Xinping , Chen Qian , Ma Daqing , Liu Zhiheng
Published: July 2021

Long-term neurodevelopmental disorders following neonatal anesthesia have been reported both in young animals and in children. The activation of transient receptor potential vanilloid 1 (TRPV1) channels in hippocampus adversely affects neurodevelopment. The current study explored the underlying mechanism of TRPV1 channels on long-lasting cognitive dysfunction induced by anesthetic exposure to the developing brain. we demonstrated that TRPV1 expression was increased after sevoflurane exposure both in vitro and in vivo. Sevoflurane exposure to hippocampal neurons decreased the synaptic density and the surface GluA1 expression, as well as increased co-localization of internalized AMPAR in early and recycling endosomes. Sevoflurane exposure to newborn mice impaired learning and memory in adulthood, and reduced AMPAR subunit GluA1, 2 and 3 expressions in the crude synaptosomal fractions from mouse hippocampus. The inhibition of TRPV1 reversed the phenotypic changes induced by sevoflurane. Moreover, sevoflurane exposure increased Src phosphorylation at tyrosine 416 site thereby reducing cofilin phosphorylation. TRPV1 blockade reversed these suppressive effects of sevoflurane. Our data suggested that TRPV1 antagonist may protect against synaptic damage and cognitive dysfunction induced by sevoflurane exposure during the brain developing stage.
Playing With Fire: Proinflammatory Virulence Mechanisms of Group A Streptococcus
Authors: Wilde Shyra , Johnson Anders F. , LaRock Christopher N.
Published: July 2021

Group A Streptococcus is an obligate human pathogen that is a major cause of infectious morbidity and mortality. It has a natural tropism for the oropharynx and skin, where it causes infections with excessive inflammation due to its expression of proinflammatory toxins and other virulence factors. Inflammation directly contributes to the severity of invasive infections, toxic shock syndrome, and the induction of severe post-infection autoimmune disease caused by autoreactive antibodies. This review discusses what is known about how the virulence factors of Group A Streptococcus induce inflammation and how this inflammation can promote disease. Understanding of streptococcal pathogenesis and the role of hyper-immune activation during infection may provide new therapeutic targets to treat the often-fatal outcome of severe disease.