bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Residue Analysis of Thyreostats in Animal Muscle Tissues by Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry: A Thorough Chromatographic Study
Authors: Kritikou Anastasia S. , Dasenaki Marilena E. , Maragou Niki C. , Kostakis Marios G. , Thomaidis Nikolaos S.
Published: September 2024

Τhyreostats (TSs) are veterinary drugs used in livestock farming for fattening. Their administration is banned in the European Union since 1981, and their monitoring for food quality and safety control requires sensitive and confirmatory methods. The present study describes the development and validation of a hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC-MS/MS) method for the simultaneous determination of 2-thiouracil (TU), 6-methyl-2-thiouracil (MTU), 6-propyl-2-thiouracil (PTU), 6-phenyl-2-thiouracil (PhTU), tapazole (TAP), and 2-mercaptobenzimidazole (MBI) in bovine muscle tissues. Investigation of the retention mechanism of the six analytes on the selected amide-based stationary phase showed that hydrophilic partition was the dominant interaction. The sample preparation included extraction with ACN/H2O (80/20), followed by dispersive solid-phase extraction (d-SPE) with C18 sorbent and hexane partitioning. The method was validated according to European guidelines using internal standards, including isotopically labelled ones. The method’s LODs ranged between 2.8 ng g−1 (6-phenyl-2-thiouracil) and 4.1 ng g−1 (2-thiouracil). Application of the proposed method to 48 bovine tissue samples showed non-detectable results.
Rapid Purification and Quantification of Intestinal and Fecal Short-Chain Fatty Acids by Solid-Phase Extraction Using Bond Elut Plexa
Authors: Zheng Xing , Chen Tao , Li Wanli , Wang Kai , Xue Xiaofeng , Naumovski Nenad , Peng Wenjun
Published: September 2024

Short-chain fatty acids (SCFAs) in feces are inextricably linked to intestinal homeostasis and can be used as potential markers for metabolic diseases. In this study, an efficient and simple method was developed for the purification of SCFAs without the need for derivatization of the samples. The SCFAs (acetic, propionic, isobutyric, butyric, isovaleric, valeric, and hexanoic acid) were extracted from a small amount (50 mg) of fecal and intestinal samples using acetone combined with solid phase extraction column (Bond Elut Plexa) enrichment. Quantitative analysis was performed using gas chromatography with a flame ionization detector. The developed method has shown very good limits of detection (LOD, 0.11–0.36 μM) and limits of quantification (LOQ, 0.38–1.21 μM) with excellent linearity (R2 ≥ 0.9998), good recovery (98.34–137.83%), and high reproducibility (RSD ≤ 1.30). The applicability of this method was also demonstrated by testing the fecal and cecum contents of different species from mammals (mice, pigs) to insects (honeybees). The technique is highly suitable for analyzing complex, small amounts of intestinal and fecal SCFAs.
A Techno-Economic Analysis of a Hybrid Microgrid System in a Residential Area of Bangladesh: Optimizing Renewable Energy
Authors: Ali Md. Feroz , Hossain Md. Alamgir , Julhash Mir Md. , Ashikuzzaman Md , Alam Md Shafiul , Sheikh Md. Rafiqul Islam
Published: September 2024

In the face of a significant power crisis, Bangladesh is turning towards renewable energy solutions, a move supported by the government’s initiatives. This article presents the findings of a study conducted in a residential area of Pabna, Bangladesh, using HOMER (Hybrid Optimization of Multiple Energy Resources) Pro software version 3.14.2. The study investigates the feasibility and efficiency of a grid-connected hybrid power system, combining photovoltaics (PV), a biomass generator, and wind energy. The simulation produced six competing solutions, each featuring a distinct combination of energy sources. Among the configurations analyzed, the grid-connected PV–biomass generator system emerged as the most cost-effective, exhibiting the lowest COE at USD 0.0232, a total net present cost (NPC) of USD 321,798.00, and an annual operating cost of USD 6060.59. The system presents a simple payback period of 9.25 years, highlighting its economic viability. Moreover, this hybrid model significantly reduces CO2 emissions to 78,721 kg/year, compared to the 257,093 kg/year emissions from a solely grid-connected system, highlighting its environmental benefits. Sensitivity analyses further reveal that the system’s performance is highly dependent on solar irradiance, indicating that slight variations in solar input can significantly impact the system’s output. This study underscores the potential of integrating multiple renewable energy sources to address the power crisis in Bangladesh, offering a sustainable and economically viable solution while also mitigating environmental impacts.
Empirical Study on the Relationship between Leader–Member Exchange, Employee Trust, and Team Knowledge Sharing
Authors: Liang Qingqing , Yin Fang
Published: September 2024

Knowledge sharing is influenced not only by the attributes of the knowledge itself and the hierarchical differences among knowledge holders but also by micro-level factors such as interpersonal communication and psychological dynamics. As the demands of the new economic environment evolve, the role of knowledge sharing among team members in knowledge management has become increasingly critical. A growing body of research emphasizes the importance of sharing knowledge resources as a means of gaining strategic advantages in enterprises. Previous studies have shown that leadership behavior plays a crucial role in fostering knowledge sharing among team members. However, there is limited research on the specific pathways and mechanisms through which leadership behavior influences knowledge sharing. Additionally, existing research lacks a comprehensive examination of the structure and measurement methods of leader–member exchange (LMX), as well as its impact on employee work outcomes. This study addresses this gap by examining trust relationships through the lenses of social identity and emotional interaction, with trust serving as a mediating variable to explore the impact of leader–subordinate interactions on knowledge sharing behavior. Drawing on the relevant literature, the study focuses on 358 employees, investigating the relationship between LMX as the independent variable, team knowledge sharing as the dependent variable, and employee trust as the mediating factor. The research findings are as follows: (1) The quality of the LMX relationship significantly influences employees’ team knowledge sharing; higher-quality LMX relationships are associated with increased knowledge sharing among subordinates. (2) Employee trust in both leaders and colleagues has a substantial impact on team knowledge sharing, with higher levels of trust positively affecting knowledge sharing behaviors. (3) Employee trust serves as a mediating factor in the relationship between LMX and team knowledge sharing. This study delves into the dynamics between LMX, team knowledge sharing, and trust, providing practical recommendations for strengthening these relationships.
Techno-Economic Analysis of Combined Production of Wind Energy and Green Hydrogen on the Northern Coast of Mauritania
Authors: Maaloum Varha , Bououbeid El Moustapha , Ali Mohamed Mahmoud , Yetilmezsoy Kaan , Rehman Shafiqur , Ménézo Christophe , Mahmoud Abdel Kader , Makoui Shahab , Samb Mamadou Lamine , Yahya Ahmed Mohamed
Published: September 2024

Green hydrogen is becoming increasingly popular, with academics, institutions, and governments concentrating on its development, efficiency improvement, and cost reduction. The objective of the Ministry of Petroleum, Mines, and Energy is to achieve a 35% proportion of renewable energy in the overall energy composition by the year 2030, followed by a 50% commitment by 2050. This goal will be achieved through the implementation of feed-in tariffs and the integration of independent power generators. The present study focused on the economic feasibility of green hydrogen and its production process utilizing renewable energy resources on the northern coast of Mauritania. The current investigation also explored the wind potential along the northern coast of Mauritania, spanning over 600 km between Nouakchott and Nouadhibou. Wind data from masts, Lidar stations, and satellites at 10 and 80 m heights from 2022 to 2023 were used to assess wind characteristics and evaluate five turbine types for local conditions. A comprehensive techno-economic analysis was carried out at five specific sites, encompassing the measures of levelized cost of electricity (LCOE) and levelized cost of green hydrogen (LCOGH), as well as sensitivity analysis and economic performance indicators. The results showed an annual average wind speed of 7.6 m/s in Nouakchott to 9.8 m/s in Nouadhibou at 80 m. The GOLDWIND 3.0 MW model showed the highest capacity factor of 50.81% due to its low cut-in speed of 2.5 m/s and its rated wind speed of 10.5 to 11 m/s. The NORDEX 4 MW model forecasted an annual production of 21.97 GWh in Nouadhibou and 19.23 GWh in Boulanoir, with the LCOE ranging from USD 5.69 to 6.51 cents/kWh, below the local electricity tariff, and an LCOGH of USD 1.85 to 2.11 US/kg H2. Multiple economic indicators confirmed the feasibility of wind energy and green hydrogen projects in assessed sites. These results boosted the confidence of the techno-economic model, highlighting the resilience of future investments in these sustainable energy infrastructures. Mauritania’s north coast has potential for wind energy, aiding green hydrogen production for energy goals.
A Megacities Review: Comparing Indicator-Based Evaluations of Sustainable Development and Urban Resilience
Authors: Mackay Brian R. , Shaker Richard R.
Published: September 2024

Urbanization is defining global change, and megacities are fast becoming a hallmark of the Anthropocene. Humanity’s pursuit toward sustainability is reliant on the successful management of these massive urban centers and their progression into sustainable and resilient settlements. Indicators and indices are applied assessment and surveillance tools used to measure, monitor, and gauge the sustainable development and urban resilience of megacities. Unknown is how indicator-based evaluations of sustainable development and urban resilience of the world’s largest 43 cities compare. In response, this review paper used the PRISMA reporting protocol, governed by 33 established and 10 emerging megacities, to compare and contrast evaluations of sustainable development and urban resilience. Results reveal that applied assessments of sustainable development of megacities appeared earlier in time and were more abundant than those of urban resilience. Geographically, China dominated other nations in affiliations to scientific research for both sustainable development and urban resilience of megacities. Among the 100 most recurrent terms, three distinct key term clusters formed for sustainable development; seven budding key term clusters formed for urban resilience suggesting breadth in contrast to sustainable development depth. The most cited assessments of sustainable development emphasize topics of energy, methodological approaches, and statistical modeling. The most cited assessments of urban resilience emphasize topics of flooding, transit networks, and disaster risk resilience. Megacities research is dominated by few countries, suggesting a need for inclusion and international partnerships. Lastly, as the world’s people become increasingly urbanized, sustainable development and urban resilience of megacities will serve as a key barometer for humanity’s progress toward sustainability.
Challenges of Implementing Municipal Solid Waste Separation Policy in China
Authors: Ren Zhuoya , Zuo Ganggang
Published: September 2024

Rapid population growth, urbanization, and diverse production materials have led to a surge in municipal solid waste (MSW), harming the environment, climate, and sanitation. Despite China’s efforts to implement MSW segregation policies, results have been unsatisfactory. Research often emphasizes public participation, with less focus on the entire policy implementation process. This paper employed Smith’s theoretical model to comprehensively analyze the challenges of implementing a MSW segregation policy, using qualitative methods and secondary data from literature and policy documents. The findings revealed challenges at four levels: policy formulation, implementing agencies, target groups, and the external environment. Issues include policy ambiguity, unclear authority, government-enterprise cross-functionality, casual attitudes, implementer shortages, poor public participation, and economic disparities. To address these, the study recommends enhancing public engagement, clarifying responsibilities among agencies, and increasing financial support for disadvantaged areas to improve policy implementation.
Development of Digital Transformation Maturity Assessment Model for Collaborative Factory Involving Multiple Companies
Authors: Lee Keeeun , Song Youngchul , Park Minyoung , Yoon Byungun
Published: September 2024

Recent advancements in digital transformation (DX) in the industrial sector have spotlighted digital collaborative factories, which emphasize relationships with partners, particularly in the manufacturing sector. However, existing DX maturity assessment models primarily focus on evaluating individual companies, lacking consideration of partnerships and thereby failing to reflect the complexities of collaborative systems. To address this limitation, this study aims to develop a DX maturity assessment model tailored to digital collaborative factories while accounting for collaborative relationships. Initially, 25 existing DX maturity assessment models were reviewed, and the evaluation elements related to collaboration were extracted from each. Accordingly, the maturity assessment model was created with 15 evaluation factors, including organizational aspects, process management, quality control, and logistics operations. Finally, to verify the applicability of the model, the DX maturity levels of a lead company—a forklift-manufacturing company—and its partner—an automotive component manufacturer—within the same value chain were assessed, and the model’s suitability was evaluated. The results indicate that the lead company needed to improve on the intelligence, connectivity, and automation aspects, while its partner needs to streamline production process operations and technological connectivity. This approach enables manufacturers to obtain more reliable information in resolving issues arising from collaboration with partners, as well as in establishing future strategies. The findings suggest that strengthening collaboration systems among partners and advancing DX based on digital collaboration will raise competitiveness within the manufacturing sector.
Heritage Regeneration Models for Traditional Courtyard Houses in a Northern Chinese City (Jinan) in the Context of Urban Renewal
Authors: Chen Meng , Wang Hechi , Hu Zhanfang , Zhou Qi , Zhao Liang
Published: September 2024

The fundamental disputes in urban heritage regeneration stem from variations in power dynamics and inherent value systems among stakeholders. Addressing conflicts and power differentials involving governmental bodies, market forces, community residents, experts, and scholars is crucial for fostering sustainable urban heritage development. Recently, these contradictions have grown more pronounced as China’s urbanization has transitioned from rapid expansion to a phase focused on existing urban assets. In the present research, the typical traditional courtyard-style residential buildings in Jinan, a historic city in northern China, were selected as the object of study. These houses often suffer from problems such as outdated infrastructure and low living conditions and have become difficult to adapt to contemporary urban life. A case study approach was employed focusing on a representative courtyard house to develop models for renewing and regenerating urban heritage, specifically tailored to traditional courtyard houses. The aim was to address conflicts and power disparities among urban heritage stakeholders through diverse mechanisms. Methodologically, the research integrates historical study and field investigation, participatory analysis, and policy analysis. Primary data sources include field surveys, historical research, oral interviews, and drone aerial photography. Models were constructed in the present study—namely, the heritage self-renewal, heritage revitalization, and heritage transformation models—for traditional courtyard houses. These models were designed to foster sustainable urban heritage development through collaborative efforts across various stakeholders and administrative levels. They will optimize the renewal mechanism of urban heritage, thus providing diversity and multiple possibilities for the preservation and reuse of architectural heritage in China. They aim to realize comprehensive urban heritage values, including vitality, health, efficiency, and equity, while accommodating the interests of diverse stakeholders.
Two-Step Simplified Modulus-Based Matrix Splitting Iteration Method for Linear Complementarity Problems
Authors: Fang Ximing
Published: September 2024

A two-step simplified modulus-based matrix splitting iteration method is presented for solving the linear complementarity problem. According to general matrix splitting and special matrix splitting, a general convergence analysis and a specific convergence analysis are described, respectively. Numerical experiments show that the iteration method is effective and that the convergence theories are valid.
Three Weaker Forms of Soft Faint Continuity
Authors: Al-Ghour Samer , Abuzaid Dina
Published: September 2024

The authors of this paper introduce and discuss three weaker forms of soft faint continuity: soft faint semi-continuity, soft faint pre-continuity, and soft faint β-continuity. They characterize each of them in several ways. They also demonstrate how they are preserved under some restrictions. Moreover, they prove that a soft function is also soft faint semi-continuous (resp. soft faint pre-continuous, soft faint β-continuous) if its soft graph function is also soft faint semi-continuous (resp. soft faint pre-continuous, soft faint β-continuous). Moreover, they show that a soft function is soft faint semi-continuous (resp. soft faint pre-continuous, soft faint β-continuous) iff it is soft semi-continuous provided that it has a soft regular codomain. Finally, the symmetry between our new ideas and their analogous topological ones is investigated.
Positional Effects of a Fly’s Wing Vein in the Asymmetric Distribution of Hydraulic Resistances
Authors: Sugiyama Kazuki , Kubota Yoshihiro , Mochizuki Osamu
Published: September 2024

Insect wing vein networks facilitate blood transport with unknown haemodynamic effects on their structures. Fruit flies have the posterior cross vein (PCV) that disrupts the symmetry of the network topology and reduces the total pressure loss during blood transport; however, the impact of its various positions among species has not been examined. This study investigated the haemodynamic effects of this vein with various connecting positions. By analogising venous networks to hydraulic circuits, the flow rates and pressure losses within the veins were derived using Poiseuille’s and Kirchhoff’s laws. The results showed that the total pressure loss decreased for both PCV connections near the wing’s base. In an idealised circuit imitating the network topology, applied high hydraulic resistances as one-sided as those along the edge of the wing, the same pressure loss response as that in the actual network was demonstrated, but not within a symmetric resistance distribution. Therefore, the most proximal PCV minimises the pressure loss within the asymmetric resistance distribution, indicating an evolutionary adaptation to reducing the pressure loss in certain species with this vein near the base. Our findings highlight the possible optimisation of the flies’ wing morphology to maintain the functions of the liquid transport networks and flight devices simultaneously.
Does Government Digital Transformation Drive High-Quality Urban Economic Development? Evidence from E-Government Platform Construction
Authors: Xiong Li , Wang Xiaoyu , Liu Zijie , Long Xiaoliang
Published: September 2024

Digitalization represents a pivotal global development trend and serves as a significant force propelling economic and social transformation. This manuscript uses the global Malmquist–Luenberger (GML) model to estimate green total factor productivity (GTFP) across 284 Chinese cities from 2003 to 2018, taking the pilot policy of “construction and application of e-government public platforms based on cloud computing” as an example to assess the impact of government digital transformation on the qualitative development of the economy by using a difference-in-differences model to explore the path of its role and driving mechanism. The results reveal that government digital transformation promotes the qualitative improvement of the city’s economic development, and its driving effect shows a marginal incremental law. Moreover, government digital transformation can contribute to the formation of a “latecomer advantage” in the lagging regions, which creates a “catch-up effect” on the regions with favorable development foundations, excellent geographical conditions, high urban ranking, and high education quality. Additionally, government digital transformation boosts economic and social development quality through both innovation spillover and structural optimization.
Perspectives on the Toxic Effects of Micro- and Nanoplastics on the Environment: A Bibliometric Analysis of the 2014 to 2023 Period
Authors: Li Xianhong , Li Zhonghong
Published: September 2024

Over the past decade, micro- and nanoplastics (MNPs) have garnered significant attention due to their frequent detection in and potential toxic effects on the environment and organisms, making them a serious threat to human health. To comprehensively understand the research on MNPs’ toxicity, we employed the R language-based Bibliometrix toolkit (version 4.3.0), VOSviewer (version 1.6.11) and CiteSpace (version 6.3.R1) to perform statistical and visual analyses of 3541 articles pertaining to MNPs’ toxicity between 2014 and 2023, which were retrieved from the Web of Science Core Collection (WOSCC) database. The analysis revealed that research related to MNPs’ toxicity has experienced a rapid increase in recent years. China’s particularly prominent influence in the field of MNPs’ toxicity is evidenced by its academic exchanges and the establishment of a mature cooperation system with other countries (regions), such as the USA and Germany. Studies related to MNPs’ toxicity are primarily published in leading journals, including the Science of the Total Environment, Environmental Pollution, and the Journal of Hazardous Materials. The Chinese Academy of Sciences was identified as the leading institution in terms of research on MNPs’ toxicity, contributing 203 papers to the total number of studies published. Keyword co-occurrence and burst analyses indicated that the current research on MNPs’ toxicity mainly focuses on the toxic effects of MNPs on aquatic organisms, the combined toxicity of MNPs and other contaminants, and the toxic effects and mechanisms of MNPs. Future research should integrate computational toxicology and toxicomics to enhance our understanding of MNPs’ toxicity mechanisms and assess the potential health risks posed by atmospheric MNPs.
Proteome and Phosphoproteome Profiling Reveal the Toxic Mechanism of Clostridium perfringens Epsilon Toxin in MDCK Cells
Authors: Yue Nan , Huang Jing , Dong Mingxin , Li Jiaxin , Gao Shan , Wang Jing , Wang Yingshuang , Li Dongxue , Luo Xi , Liu Tingting , Han Songyang , Dong Lina , Chen Ming , Wang Jinglin , Xu Na , Kang Lin , Xin Wenwen
Published: September 2024

Epsilon toxin (ETX), a potential agent of biological and toxic warfare, causes the death of many ruminants and threatens human health. It is crucial to understand the toxic mechanism of such a highly lethal and rapid course toxin. In this study, we detected the effects of ETX on the proteome and phosphoproteome of MDCK cells after 10 min and 30 min. A total of 44 differentially expressed proteins (DEPs) and 588 differentially phosphorylated proteins (DPPs) were screened in the 10 min group, while 73 DEPs and 489 DPPs were screened in the 30 min group. ETX-induced proteins and phosphorylated proteins were mainly located in the nucleus, cytoplasm, and mitochondria, and their enrichment pathways were related to transcription and translation, virus infection, and intercellular junction. Meanwhile, the protein–protein interaction network screened out several hub proteins, including SRSF1/2/6/7/11, SF3B1/2, NOP14/56, ANLN, GTPBP4, THOC2, and RRP1B. Almost all of these proteins were present in the spliceosome pathway, indicating that the spliceosome pathway is involved in ETX-induced cell death. Next, we used RNAi lentiviruses and inhibitors of several key proteins to verify whether these proteins play a critical role. The results confirmed that SRSF1, SF3B2, and THOC2 were the key proteins involved in the cytotoxic effect of ETX. In addition, we found that the common upstream kinase of these key proteins was SRPK1, and a reduction in the level of SRPK1 could also reduce ETX-induced cell death. This result was consistent with the phosphorylated proteomics analysis. In summary, our study demonstrated that ETX induces phosphorylation of SRSF1, SF3B2, THOC2, and SRPK1 proteins on the spliceosome pathway, which inhibits normal splicing of mRNA and leads to cell death.
Immunity Debt Regarding the Aspect of Influenza in the Post-COVID-19 Era in Taiwan
Authors: Wu Edward , Wu Victoria , Wu Kang-Hsi , Wu Kun-Chan , Huang Jing-Yang
Published: September 2024

Immunity debt for various viral infections was reported globally in the post-COVID-19 era, but the data about influenza are lacking. This study collected data from Taiwan’s CDC Open Data Portal. We analyzed the weekly number of influenza hospitalizations from January 2017 to May 2024. We divided the study period into four phases: the pre-COVID-19 without influenza epidemics, pre-COVID-19 with an influenza epidemic, COVID-19 pandemic lockdown control, and COVID-19 pandemic unlock periods. The Wilcoxon rank-sum test and interrupted time series analysis were used. The median case numbers of the four time periods were 174 (IQR = 98), 431 (IQR = 160), 8, and 155 (IQR = 175), respectively. Under the COVID-19 pandemic lockdown control, the weekly influenza hospitalization case number decreased by 90.2% (p < 0.001). The non-pharmaceutical intervention (NPI) policies during the COVID-19 pandemic helped Taiwan reduce influenza hospitalizations significantly. Till now, a comparison of the prevalence of influenza pre-COVID-19 and post-COVID-19 has yet to be reported. In our study, with the pandemic unlocking, it increased by 20-fold (p < 0.001), but the case number was still significantly lower than that pre-COVID-19. Amongst other factors, this may be associated with continuing self-induced NPIs in Taiwan.
Occurrence and Distribution of Major Cassava Pests and Diseases in Cultivated Cassava Varieties in Western Kenya
Authors: Wosula Everlyne N. , Shirima Rudolph R. , Amour Massoud , Woyengo Vincent W. , Otunga Bonface M. , Legg James P.
Published: September 2024

Cassava is an important food crop in western Kenya, yet its production is challenged by pests and diseases that require routine monitoring to guide development and deployment of control strategies. Field surveys were conducted in 2022 and 2023 to determine the prevalence, incidence and severity of cassava mosaic disease (CMD) and cassava brown streak disease (CBSD), whitefly numbers and incidence of cassava green mite (CGM) in six counties of western Kenya. Details of the encountered cassava varieties were carefully recorded to determine the adoption of improved varieties. A total of 29 varieties were recorded, out of which 13 were improved, although the improved varieties were predominant in 60% of fields and the most widely grown variety was MM96/4271. The CMD incidence was higher in 2022 (26.4%) compared to 2023 (10.1%), although the proportion of CMD attributable to whitefly infection was greater (50.6%) in 2023 than in 2022 (18.0%). The CBSD incidence in 2022 was 6.4%, while in 2023 it was 4.1%. The CMD incidence was significantly lower (5.9%) for the improved varieties than it was for the local varieties (35.9%), although the CBSD incidence did not differ significantly between the improved (2.3%) and local varieties (9.7%). Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) were both detected. Most infections were single CBSV infections (82.9%), followed by single UCBSV (34.3%) and coinfection with both viruses (16.7%). Whiteflies were more abundant in 2023, in which 28% of the fields had super-abundant populations of >100/plant, compared to 5% in 2022. KASP SNP genotyping designated 92.8% of the specimens as SSA-ECA for 2022, while it was 94.4% for 2023. The cassava green mite incidence was 65.4% in 2022 compared to 79.9% in 2023. This study demonstrates that cassava viruses, whiteflies and cassava green mites continue to be important constraints to cassava production in western Kenya, although the widespread cultivation of improved varieties is reducing the impact of cassava viruses. The more widespread application of high-quality seed delivery mechanisms could further enhance the management of these pests/diseases, coupled with wider application of IPM measures for whiteflies and mites.
Knowledge and Awareness of Risk Factors for HIV Infection and about HIV Testing among Medical Students in Warsaw
Authors: Kowalska Justyna , Cholewik Martyna , Bieńkowski Carlo , Maciejczyk Aleksandra , Bursa Dominik , Skrzat-Klapaczyńska Agata
Published: September 2024

Background: The number of late diagnoses of HIV remains very high in Poland, leading to a high proportion of patients developing and dying of HIV-related diseases. The main reason for this is the very low utilization of HIV testing. Our analyses aimed to investigate knowledge about the indications for HIV testing among medical university students, as well as identify their own HIV testing experiences. Material and methods: A cross-sectional survey study was designed to collect information on the students’ demographics and their experiences of HIV testing, as well as their knowledge of virus transmission and the indications for testing. Data were collected as part of the HIV_week@WUM project conducted at the Medical University of Warsaw in parallel with the 18th European AIDS Conference, which took place in Warsaw between 18 and 21 October 2023. Results: In total, 545 questionnaires were collected. The median age of the study participants was 20 (interquartile range (IQR): 19–22 years). The majority of respondents were as follows: women (67.5%), born in Poland (97.8%), and were attending the medical faculty (56.7%). Only 114 (21.43%) participants had ever been tested for HIV. For all modes of HIV transmission, most of the respondents overestimated the risk of acquiring HIV, but, at the same time, they had never been tested for HIV. Conclusions: Only one in five health sciences students has ever had a test for HIV, which is less than estimates for the general population of Warsaw. There is an ongoing need to popularize testing among future health care providers in order to address both the indications for testing for individuals and the better use of HIV testing in clinical practice.
Breaking Latent Infection: How ORF37/38-Deletion Mutants Offer New Hope against EHV-1 Neuropathogenicity
Authors: Hu Yue , Zhang Si-Yu , Sun Wen-Cheng , Feng Ya-Ru , Gong Hua-Rui , Ran Duo-Liang , Zhang Bao-Zhong , Liu Jian-Hua
Published: September 2024

Equid alphaherpesvirus 1 (EHV-1) has been linked to the emergence of neurological disorders, with the horse racing industry experiencing significant impacts from outbreaks of equine herpesvirus myeloencephalopathy (EHM). Building robust immune memory before pathogen exposure enables rapid recognition and elimination, preventing infection. This is crucial for effectively managing EHV-1. Removing neuropathogenic factors and immune evasion genes to develop live attenuated vaccines appears to be a successful strategy for EHV-1 vaccines. We created mutant viruses without ORF38 and ORF37/38 and validated their neuropathogenicity and immunogenicity in hamsters. The ∆ORF38 strain caused brain tissue damage at high doses, whereas the ∆ORF37/38 strain did not. Dexamethasone was used to confirm latent herpesvirus infection and reactivation. Dexamethasone injection increased viral DNA load in the brains of hamsters infected with the parental and ∆ORF38 strains, but not in those infected with the ∆ORF37/38 strain. Immunizing hamsters intranasally with the ∆ORF37/38 strain as a live vaccine produced a stronger immune response compared to the ∆ORF38 strain at the same dose. The hamsters demonstrated effective protection against a lethal challenge with the parental strain. This suggests that the deletion of ORF37/38 may effectively inhibit latent viral infection, reduce the neuropathogenicity of EHV-1, and induce a protective immune response.
Analysis and Identification of Eccentricity of Axial-Flow Impeller by Variational Mode Decomposition
Authors: Zhang Houyu , Guan Yingbo , Hu Zilong , Guang Weilong , Zhu Di , Tao Ran , Xiao Ruofu
Published: September 2024

The axial-flow impellers are widely applied to industry due to their excellent hydraulic performance and simple structure, but they may be affected by their eccentricity during operation. This study compared and studied the effects of the axial-flow eccentricity of an impeller on hydraulic performance, impeller radial force, and downstream pressure pulsation of the unit. The research results indicate that impeller eccentricity has a small effect on hydraulic performance. Compared with the design conditions, the efficiency, power, and head changes caused by impeller eccentricity are all less than 1%, but the impeller eccentricity leads to a sharp increase in the radial force of the impeller. Under the design conditions, the average value of the radial force of the impeller is 31.38 N; under eccentric conditions, the average value of the radial force of the impeller increased by nine times, reaching 316.30 N. By analyzing the pressure pulsation signals decomposed by the VMD method, it is shown that the influence of eccentricity on pressure pulsation is mainly reflected in the increase in impeller frequency on pressure pulsation. Under design conditions, the corresponding amplitude of the impeller frequency is 2.6; under eccentric conditions, the amplitude corresponding to the impeller frequency increased by 100 times, reaching 274.4. This study elucidates the specific effects of axial impeller eccentricity, providing theoretical guidance for the safe and stable operation of axial-flow units, and has important engineering significance.
Application of Marine Mollusk Shells (Meretrix lusoria) as Low-Cost Biosorbent for Removing Cd2+ and Pb2+ Ions from Aqueous Solution: Kinetic and Equilibrium Study
Authors: Al-Mur Bandar A.
Published: September 2024

The present work aims to evaluate the applicability of mollusk (Meretrix lusoria) shells as a biosorbent for toxic metal ions (Cd2+ and Pb2+) following the batch mode biosorption procedure. Some well-known analytical methods have been used to characterize the biosorbent such as a scanning electron microscope (SEM), an energy dispersive X-ray (EDX), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction. The mechanism of metal ion biosorption was examined using various analytical techniques. Therefore, an evaluation of operating factors such as contact time, pH, initial concentration of metal ions, biosorbent dose, and temperature was performed. The results obtained in this investigation indicated that the optimum conditions for the biosorption of Cd+2 and Pb+2 ions are as follows: pH = 6; contact times of 90 min; and the 20 mg/L of initial [M2+]. And a biosorbent dosage of 1.0 g/100 mL for each metal ion solution was also determined. The maximum removal efficiency results were 90.6% for Cd+2 and 91.5% for Pb+2 at pH 6.0. The biosorption isotherm was investigated using three forms of linear equilibrium (Freundlich, Langmuir, and Temkin models). Kinetic studies were also conducted to determine the equilibrium time for the biosorption of the studied metals utilizing the pseudo-second-order, pseudo-first-order, and intraparticle diffusion model. The data indicate that the biosorption kinetics of Cd2+ and Pb2+ follow the pseudo-second-order models. According to the present study, it can be identified that the shell of Meretrix lusoria is a suitable biosorbent for Cd2+ and Pb2+ ions and can contribute to their removal from environmentally polluted water.
Drinking Water Quality in Delta and Non-Delta Counties along the Mississippi River
Authors: Pickering Emily V. , Jia Chunrong , Naser Abu Mohd
Published: September 2024

The Mississippi Delta region has worse population health outcomes, including higher overall cardiovascular and infant mortality rates. Water quality has yet to be considered as a factor in these health disparities. The objective of this paper is to determine overall differences in basic water quality indicators, electrolytes of cardiovascular importance, trace elements, heavy metals, and radioactive ions of groundwater in delta and non-delta counties in states along the Mississippi River. Data were sourced from the major-ions dataset of the U.S. Geological Survey. We used the Wilcoxon rank sum test to determine the difference in water quality parameters. Overall, delta counties had lower total dissolved solids (TDS) (47 and 384 mg/L, p-value < 0.001), calcium (7 and 58 mg/L; p-value < 0.001), magnesium (2 and 22 mg/L; p-value < 0.001), and potassium (1.57 and 1.80 mg/L; p-value < 0.001) and higher sodium (38 mg/L and 22 mg/L; p-value < 0.001) compared to non-delta counties. Overall, there were no statistical differences in trace elements, heavy metals, and radioactive ions across delta versus non-delta counties. These results underscore the need for further epidemiological studies to understand if worse health outcomes in delta counties could be partially explained by these parameters.
Thickness and Structure of Permafrost in Oil and Gas Fields of the Yamal Peninsula: Evidence from Shallow Transient Electromagnetic (sTEM) Survey
Authors: Misyurkeeva Natalya , Buddo Igor , Shelokhov Ivan , Smirnov Alexander , Nezhdanov Alexey , Agafonov Yuri
Published: September 2024

The Yamal-Nenets Autonomous District, especially the Yamal Peninsula located in the permafrost zone, stores Russia’s largest oil and gas resources. However, development in the area is challenging because of its harsh climate and engineering–geological features. Drilling in oil and gas fields in permafrost faces problems that are fraught with serious accident risks: soil heaving leading to the collapse of wellheads and hole walls, deformation and breakage of casing strings, gas seeps or explosive emissions, etc. In this respect, knowledge of the permafrost’s structure is indispensable to ensure safe geological exploration and petroleum production in high-latitude regions. The extent and structure of permafrost in West Siberia, especially in its northern part (Yamal and Gydan Peninsulas), remain poorly studied. More insights into the permafrost’s structure have been obtained by a precise sTEM survey in the northern Yamal Peninsula. The sTEM soundings were performed in a large oil and gas field where permafrost is subject to natural and anthropogenic impacts, and its degradation, with freezing–thawing fluctuations and frost deformation, poses risks to exploration and development operations, as well as to production infrastructure. The results show that permafrost in the western part of the Yamal geocryological province is continuous laterally but encloses subriver and sublake unfrozen zones (taliks) and lenses of saline liquid material (cryopegs). The total thickness of perennially frozen rocks is 200 m. The rocks below 200 m have negative temperatures but are free from pore ice. Conductive features (<10 Ohm﮲m) traceable to the permafrost base may represent faults that act as pathways for water and gas fluids and, thus, can cause a geohazard in the oil and gas fields (explosion of frost mounds, gas blow during shallow drilling, etc.).
Machine Learning Structure for Controlling the Speed of Variable Reluctance Motor via Transitioning Policy Iteration Algorithm
Authors: Alharkan Hamad
Published: September 2024

This paper investigated a new speed regulator using an adaptive transitioning policy iteration learning technique for the variable reluctance motor (VRM) drive. A transitioning strategy is used in this unique scheme to handle the nonlinear behavior of the VRM by using a series of learning centers, each of which is an individual local learning controller at linear operational location that grows throughout the system’s nonlinear domain. This improved control technique based on an adaptive dynamic programming algorithm is developed to derive the prime solution of the infinite horizon linear quadratic tracker (LQT) issue for an unidentified dynamical configuration with a VRM drive. By formulating a policy iteration algorithm for VRM applications, the speed of the motor shows inside the machine model, and therefore the local centers are directly affected by the speed. Hence, when the speed of the rotor changes, the parameters of the local centers grid would be updated and tuned. Additionally, a multivariate transition algorithm has been adopted to provide a seamless transition between the Q-centers. Finally, simulation and experimental results are presented to confirm the suggested control scheme’s efficacy.
Social and hygienic monitoring is the first step towards digitalization of preventive medicine
Authors:   Moscow City University, Moscow, Russia, Denisov L. A. ,   Academy of Postgraduate Education of the Federal State Budgetary Educational Institution FNCC FMBA of Russia, Moscow, Russia
Published: September 2024

Sanitary and hygienic monitoring is an important component of the sanitary and epidemiological surveillance system, which allows continuous monitoring of potentially negative environmental factors. The purpose of the work is to analyze the experience of organizing social and hygienic monitoring in the Zelenograd administrative district of Moscow and to show its role in the modern development of preventive medicine. The materials for this study were scientific articles devoted to the experience of implementing social and hygienic monitoring in the Zelenograd administrative district. Moscow, as well as regulatory, legal and methodological acts devoted to this problem. The result of the conducted research was a description of the successes and failures of social and hygienic monitoring since its inception in the Zelenograd JSC of Moscow, the understanding of which can be used to develop monitoring research and digitalize their results.
Professional burnout of medical workers working in a specialized COVID hospital
Authors:   Samara State Medical University,Samara, Russia, Babanov S. A. , Ostryakova N. A. ,   Samara State Medical University,Samara, Russia, Lysova M. V. ,   Samara State Medical University,Samara, Russia, O. V. Sazonova O. V. Sazonova ,   Samara State Medical University,Samara, Russia, Gavryushin M. Yu. ,   Samara State Medical University,Samara, Russia, Kuvshinova N. Yu. ,   Samara State Medical University,Samara, Russia
Published: September 2024

In order to assess the features of the development of emotional burnout syndrome among medical workers working in the «red zone», the following groups of medical workers working in the «red zone» were examined: Group 1 — general practitioners (n=111); group 2 — surgeons (n=61); group 3 — nurses (n=29); group 4 — control group — intellectual workers who are not related to work in medical organizations (n=190). The assessment of the burnout syndrome was carried out using the «Maslach Burnout» method and the V. V. Boyko method. It has been established that the work of internists, surgeons, and nurses working in the «red zone» is associated with the impact on medical workers of factors of the production environment and the labor process associated with an increased level of professional stress, leading to emotional burnout.
Neuroimaging findings from a case of neurocysticercosis
Authors: Rojas Urrea Alejandro , Arias-Mariño Daniela , Niño Moreno Mónica Paola , Sanchez Coronel Natalia , García Agudelo Lorena
Published: September 2024

Introduction: Human cysticercosis occurs when humans ingest Taenia solium eggs from the fecal-oral route. The infection in the central nervous system is called neurocysticercosis and is considered the principal cause of late-onset epilepsy in endemic countries in Latin America, Asia, and Africa.
Case report: 71-year-old female in a state of neglect with a medical history of untreated rheumatoid arthritis. She presented her first seizure episode. Cerebral magnetic resonance imaging with contrast reported parenchymal and subarachnoid neurocysticercosis in different stages.
Discussion: The high incidence of neurocysticercosis in endemic countries is associated with poverty conditions such as less hygienic conditions and permanent contact with domestic animals. The four stages of classification of neurocysticercosis is useful for pathologists and radiologists to identify the life cycle of the parasite within the body and the specific imaging findings of each phase. After diagnosis, treatment includes the use of niclosamide or praziquantel.
Conclusions: neurocysticercosis is a public health problem in endemic countries that requires further attention. Clinical manifestations are variable and neuroimaging findings are essential to making a correct diagnosis.
El aprendizaje virtual en la educación superior: Una revisión sistemática
Authors: Sánchez Díaz Edwin , Dávila Rojas Oscar Melanio
Published: September 2024

La virtualización educativa en la educación superior ha adquirido gran relevancia al facilitar el uso de Tecnologías de la Información y Comunicación (TIC) en la formación universitaria. Este artículo explora la importancia de la educación virtual, sus características y la necesidad de su sostenibilidad. El objetivo es evaluar el impacto de la virtualización en el desarrollo de actividades investigativas, el rol del docente y la autonomía del estudiante. Se realizó una revisión sistemática de literatura a partir de fuentes de Scielo, Scopus y Web of Science. Los resultados indican que la mayoría de los artículos provienen de Scopus (57%), con un 62% en inglés y un 38% en español, y que el 85% de los estudios son del año 2022. La revisión revela que la educación virtual facilita la adquisición de competencias, fomenta la autonomía y permite la formación desde cualquier ubicación, siempre que exista buena conectividad. En conclusión, la virtualización educativa ha demostrado ser efectiva y necesaria, superando las limitaciones de la educación presencial y garantizando un acceso más amplio y de calidad a la educación superior.