bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulatory network of miRNA, lncRNA, transcription factor and target immune response genes in bovine mastitis
Authors: Tucker Ashley R. , Salazar Nicole A. , Ayoola Adeola O. , Memili Erdoğan , Thomas Bolaji N. , Morenikeji Olanrewaju B.
Published: November 2021

Pre- and post-transcriptional modifications of gene expression are emerging as foci of disease studies, with some studies revealing the importance of non-coding transcripts, like long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). We hypothesize that transcription factors (TFs), lncRNAs and miRNAs modulate immune response in bovine mastitis and could potentially serve as disease biomarkers and/or drug targets. With computational analyses, we identified candidate genes potentially regulated by miRNAs and lncRNAs base pair complementation and thermodynamic stability of binding regions. Remarkably, we found six miRNAs, two being bta-miR-223 and bta-miR-24-3p, to bind to several targets. LncRNAs NONBTAT027932.1 and XR_003029725.1, were identified to target several genes. Functional and pathway analyses revealed lipopolysaccharide-mediated signaling pathway, regulation of chemokine (C-X-C motif) ligand 2 production and regulation of IL-23 production among others. The overarching interactome deserves further in vitro/in vivo explication for specific molecular regulatory mechanisms during bovine mastitis immune response and could lay the foundation for development of disease markers and therapeutic intervention.
In vivo study of the effects of a portable cold plasma device and vitamin C for skin rejuvenation
Authors: Shakouri Reza , Khani Mohammad Reza , Samsavar Shirin , Jezeh Mahya Aminrayai , Abdollahimajd Fahimeh , Hosseini Seyed Iman , Dilmaghanian Aydin , Ghasemi Erfan , Alihoseini Mohammad Reza , Shokri Babak
Published: November 2021

Nowadays, cold atmospheric plasma shows interesting results in dermatology. In the present study, a new portable cold plasma was designed for plasma skin rejuvenation (PSR) purposes. This device is safe and easy to use at beauty salons and homes. The effects of this device were investigated on the rat skins. Also, as a new method to improve PSR results, vitamin C ointment was combined with plasma. In this study, there were four groups of 5 Wistar rats. The first group received vitamin C ointment, the second received 5 min of high-voltage plasma, and the third and the fourth groups received 5 min of high- and low-voltage plasma and vitamin C ointment. This process was done every other day (3 sessions per week) for 6 weeks. To evaluate the thermal effect of plasma, the skin temperature was monitored. Also, the presence of reactive species was demonstrated by the use of optical spectroscopy. In addition, mechanical assays were performed to assess the effect of plasma and vitamin C on the tissue’s mechanical strength. The mechanical assays showed a positive impact of plasma on the treated tissue compared to the control group. Also, changes in the collagen level and thickness of the epidermal layer were examined in histological studies. The results indicated an increase in collagen levels after using plasma alone and an accelerated skin reaction after using vitamin C combined with plasma therapy. The epidermal layer’s thickness increased after applying high-voltage plasma, which indicates an increase in skin elasticity. This study demonstrates the positive effect of using the portable plasma device with vitamin C ointment on effective parameters in skin rejuvenation.
Biochar increases tobacco yield by promoting root growth based on a three-year field application
Authors: Ren Tianbao , Wang Huanhuan , Yuan Ye , Feng Huilin , Wang Bo , Kuang Gang , Wei Yuewei , Gao Weikai , Shi Hongzhi , Liu Guoshun
Published: November 2021

In order to explore the effects of biochar on root system and growth characteristics of flue-tobacco, three years of field experiments were conducted to study the influence of different biochar application levels [600 (T1), 1200 (T2), 1800(T3), 2400 (T4), 3000 (T5) kg/ha] and no fertilizer (CK) on the root physiological indexes and growth index of tobacco. Compared with local conventional fertilization, the application rate of N fertilizer in each treatment (except for control) was reduced by 40% to analyze the effects of different amount of biochar on the physiological indexes of tobacco roots and leaf photosynthesis during flourishing. The results showed that tobacco plants' root development status in the flourishing period was consistent with the photosynthetic physiological indexes, chlorophyll content, and leaf-area coefficient. Compared with the control, the application of biochar could increase the root vigor by 177.8%. Biochar improved the roots, increasing the total root area by 91.35% and the number of root tips by 100.9%. Meanwhile, biochar increased the net photosynthetic rate of tobacco leaves by 77.3% and the total tobacco biomass by 72.5%. Studies have shown that biochar can promote the development of tobacco roots, and then enhance the photosynthesis of leaves, so that tobacco plants can grow healthily, which is conducive to the tobacco production and the cultivation of soil.
Factors influencing the global distribution of the endangered Egyptian vulture
Authors: Panthi Saroj , Pariyar Shiva , Low Matthew
Published: November 2021

Vultures are ecologically important primarily because of their scavenging role in cleaning carcasses of the environment. Because of anthropogenic impacts, the Egyptian vulture (Neophron percnopterus) has suffered catastrophic declines in parts of its range and, thus, information about its global distribution and factors influencing its occurrence within this range are essential for its conservation. To this end, we estimated the global distribution of Egyptian vulture and variables related to this distribution. We used occurrence points (n = 4740) from online data sources and literature, environmental variables related to these sites and Maximum Entropy software to model the distribution of this species and its relationship to environmental variables during the entire year, breeding and overwintering. Out of ~ 49 million km2study area, the Egyptian vulture had a predicted range of 6,599,508 km2distributed across three continents: Africa, Asia and Europe. The densest distribution was in Southern Europe, India and Northern Africa and a sparser distribution was around Mid and Western Africa, the Middle East and Afghanistan. Climate was related to the vulture’s most probable range: in particular medium temperature seasonality and low precipitation during the coldest yearly quarter were important variables regardless of the season of observations examined. Conservation of identified habitats and mitigation of anthropogenic impacts to conserve these vultures are recommended for immediate and long-term conservation of the Egyptian vulture globally.
A novel symmetrical imidazole-containing framework as a fluorescence sensor for selectively detecting silver ions
Authors: Wang Junjie , Lan Zhenni , Hou Shili , Hou Shifeng
Published: November 2021

In this study, a novel and highly efficient “turn-off” fluorescence imidazole-based sensor (BIB) with a symmetric structure was synthesized by a four-step reaction, from o-phenylenediamine, 6-bromo-2-pyridinecarboxaldehyde, and 1-bromohexane.
Exploration of structural transition phenomenon in flexible metal–organic framework formed on polymer substrate
Authors: Hirao Shoya , Hamagami Ruho , Ohhashi Takashi , Eguchi Keiichi , Kubo Neo , Takashima Yohei , Akamatsu Kensuke , Tsuruoka Takaaki
Published: November 2021

We investigate the structural transition of directly formed flexible MOF crystals on a polymer substrate.
Analytically and empirically consistent characterization of the resistive switching mechanism in a Ag conducting-bridge random-access memory device through a pseudo-liquid interpretation approach
Authors: Choi Yeon-Joon , Bang Suhyun , Kim Tae-Hyeon , Hong Kyungho , Kim Sungjoon , Kim Sungjun , Cho Seongjae , Park Byung-Gook
Published: November 2021

A new physical analysis of the filament formation in a Ag conducting-bridge random-access memory (CBRAM) device in consideration of the existence of inter-atomic attractions caused by metal bonding is suggested.
In situ U–Pb geochronology of vesuvianite by LA-SF-ICP-MS
Authors: Wei Qin-Di , Yang Ming , Romer Rolf L. , Wang Hao , Yang Yue-Heng , Zhao Zi-Fu , Wu Shi-Tou , Xie Lie-Wen , Huang Chao , Xu Lei , Yang Jin-Hui , Wu Fu-Yuan
Published: November 2021

LA-SF-ICP-MS method for U–Pb dating of vesuvianite with the aim of establishing well characterized U–Pb vesuvianite reference materials for microanalysis.
The impact of cyclometalated and phosphine ligands on the luminescence properties of cycloplatinated(ii) complexes: photophysical and theoretical investigations
Authors: Shahsavari Hamid R. , Paziresh Sareh
Published: November 2021

The effects of various C^N cyclometalated and phosphine ligands on the photophysical properties of cycloplatinated(ii) complexes were investigated experimentally and theoretically.
Microporous polycarbazole frameworks with large conjugated π systems for cyclohexane separation from cyclohexane-containing mixtures
Authors: Chen Liangji , Zhang Hao , Ye Yingxiang , Yuan Zhen , Wang Jiaqi , Yang Yisi , Lin Si , Xiang Fahui , Xiang Shengchang , Zhang Zhangjing
Published: November 2021

Two microporous polycarbazole frameworks with large conjugated π systems were constructed for cyclohexane separation from cyclohexane-containing mixtures.
Sex differences in the lung ACE/ACE2 balance in hypertensive rats
Authors: Martins Flavia L. , Tavares Caio A.M. , Malagrino Pamella A. , Rentz Thiago , Benetti Acaris , Rios Thiago M.S. , Pereira Gabriel M.D. , Caramelli Bruno , Teixeira Samantha K. , Krieger José E. , Girardi Adriana C.C.
Published: November 2021

The angiotensin-converting enzyme (ACE)/Angiotensin II (Ang II) and angiotensin-converting enzyme 2 (ACE2)/angiotensin-(1-7) (Ang-(1-7)) pathways are coexpressed in most tissues. The balance between these pathways determines, at least in part, whether tissue damage will occur in response to pathological stimuli. The present study tested the hypothesis that male sex and high blood pressure are associated with ACE/ACE2 imbalance in the lungs. Experiments were conducted in male and female Wistar rats and spontaneously hypertensive rats (SHRs). Lung ACE and ACE2 gene expression was also evaluated in normotensive and hypertensive humans using the Genotype-Tissue Expression (GTEx) project. Compared with Wistar rats and female SHRs, male SHRs displayed reduced lung ACE2 mRNA, ACE2 protein abundance and ACE2 activity, and increased Ang II concentration. Lung ACE mRNA levels were higher in male SHRs than in Wistar rats, whereas lung ACE protein abundance and activity were similar among the four groups of rats. Lung Ang-(1-7) concentration was higher in female than in male SHRs (89 ± 17 vs. 43 ± 2 pg/g, P<0.05). Lung ACE to ACE2 mRNA expression in hypertensive patients was significantly higher than that in normotensive subjects. Taken together, these results demonstrate that male hypertensive rats display imbalance between the ACE/Ang II and ACE2/Ang-(1-7) pathways in the lungs mainly attributable to ACE2 down-regulation. Further studies should be conducted to investigate whether this imbalance between ACE/ACE2 may promote and accelerate lung injury in respiratory infections, including coronavirus disease 2019 (COVID-19).
Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP
Authors: Rahman Md. Lutfur , Hyodo Toshinori , Hasan Muhammad Nazmul , Mihara Yuko , Karnan Sivasundaram , Ota Akinobu , Tsuzuki Shinobu , Hosokawa Yoshitaka , Konishi Hiroyuki
Published: November 2021

Targeted knock-in supported by the CRISPR/Cas systems enables the insertion, deletion, and substitution of genome sequences exactly as designed. Although this technology is considered to have wide range of applications in life sciences, one of its prerequisites for practical use is to improve the efficiency, precision, and specificity achieved. To improve the efficiency of targeted knock-in, there first needs to be a reporter system that permits simple and accurate monitoring of targeted knock-in events. In the present study, we created such a system using the PIGP gene, an autosomal gene essential for GPI-anchor biosynthesis, as a reporter gene. We first deleted a PIGP allele using Cas9 nucleases and then incorporated a truncating mutation into the other PIGP allele in two near-diploid human cell lines. The resulting cell clones were used to monitor the correction of the PIGP mutations by detecting GPI anchors distributed over the cell membrane via flow cytometry. We confirmed the utility of these reporter clones by performing targeted knock-in in these clones via a Cas9 nickase-based strategy known as tandem paired nicking, as well as a common process using Cas9 nucleases, and evaluating the efficiencies of the achieved targeted knock-in. We also leveraged these reporter clones to test a modified procedure for tandem paired nicking and demonstrated a slight increase in the efficiency of targeted knock-in by the new procedure. These data provide evidence for the utility of our PIGP-based assay system to quantify the efficiency of targeted knock-in and thereby help improve the technology of targeted knock-in.
Development and Validation of the Japanese Version of the Consensus Auditory-Perceptual Evaluation of Voice
Authors: Kondo Kanako , Mizuta Masanobu , Kawai Yoshitaka , Sogami Tohru , Fujimura Shintaro , Kojima Tsuyoshi , Abe Chika , Tanaka Ryo , Shiromoto Osamu , Uozumi Ryuji , Kishimoto Yo , Tateya Ichiro , Omori Koichi , Haji Tomoyuki
Published: November 2021

Purpose:

Auditory-perceptual evaluation is essential for the assessment of voice quality. The Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) provides a standardized protocol and assessment form for clinicians to analyze the voice quality and has been adapted into several different languages. The aims of this study were to develop the Japanese version of the CAPE-V and to investigate its reliability and validity.

Method:

The Japanese CAPE-V consisted of the same three speech contexts (vowels, sentences, and conversation) as developed in the original English version. The sentences were designed according to the concepts of the original version and reviewed by Japanese phoneticians. To validate the usefulness of the Japanese CAPE-V, voices of 173 Japanese-speaking subjects (76 subjects with dysphonia and 97 without voice complaints) were evaluated by five experienced judges, according to the Japanese CAPE-V as well as the GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) scale.

Results:

The Japanese CAPE-V provided a high interrater reliability (intraclass correlation coefficients [ICCs] > .85 for all the parameters) as well as a high intrarater reliability (ICCs > .85 for all the parameters). In addition, overall severity, roughness, and breathiness in the Japanese CAPE-V were highly correlated with the corresponding dimensions in the GRBAS scale, having Spearman correlation coefficients greater than .8.

Conclusion:

This study demonstrated the reliability and validity of the newly developed Japanese CAPE-V as an auditory-perceptual evaluation instrument.
Everyday Life Injuries among Children Under 6 Years Old: Accident or Neglect?
Authors: Lafia Toualouth , Aqqaoui Loubna , Ettayebi Fouad , Oubejja Houda
Published: November 2021

Injuries related to everyday accidents are very common in children and are the main reasons for hospitalization in pediatric surgery. They have similarities with neglect. The main objective is to assess the frequency and circumstances of the occurrence of unintentional accidents in children under 6 years old. The secondary objective is to specify the associated factors and eventually determine if those accidents can be related to neglect. Material and methods: This is a cross-sectional study carried out at Pediatric Surgical Emergencies Department of Rabat Children's Hospital in 2017. Results: We identified 363 cases of unintentional accidents. The variables were collected on questionnaire. 155 children were aged 6 and under. The median age was 2, 83 years with a predominance of boys (56%). Children over 2 years old were the most affected (55.48%). Low and middle-income families dominated socio-demographic factors. The mothers in almost half of the cases never went to school. In 65.4% of cases, an adult was present during the accident, often the mother (62%). The lesions involved the limbs (64%) and the head (47%). Hospitalization was 24 hours (60.8%). There was no complication in 96.8% of cases. Some risk factors associated with unintentional accidents are also found in negligence.
Epidemiological profile of unintentional accidents in children over a period of 4 years
Authors: Skiredj Aiat Allah , Boughaleb Fadoua , Aqqaoui Loubna , Lafia Toualouth , Mouad Assia , Erraji Mounir , Ettayebi Erraji Fouad , Oubejja Houda
Published: November 2021

Background: Unintentional injuries are one of the most important public health problems among children in developed and some developing countries.

Aim: Our purpose is to determine the prevalence of everyday life unintentional injuries among children admitted for at least 24 hours in the pediatric surgical emergencies (PSE) department, Children’s hospital of Rabat, Morocco.

Methods: A cross-sectional study of unintentional injuries in children was undertaken over 4 years (2016- 2019) in the pediatric surgical emergencies (PSE) department, Children’s hospital of Rabat, Morocco. The data were analysed by statistical software Jamovi 1.6.23. Drownings and foreign bodies were excluded.

Results: 1204 patients were screened, of which 545 files were studied. The median age was 8 years[4;12] with 36,5% were less than 6 years old, 70,4% were boys. The most injuries occurred mostly during winters and summers (41,6 vs 33,8%). The medical insurance plan was provided by compulsory medical insurance (AMO) and RAMED (Medical Assistance Scheme) (30,4% and 46.5% respectively). The main circumstances were accidents of everyday life (52%) with predominance of falls. For the public road accident, pedestrians were predominant. Hospital stay did not exceed 24 hours (73%) mainly in the surgical emergency department.
Health vigilance concerning bacteremia in neonatology - neonatal intensive care unit at the Mohammed VI University Hospital of Oujda (Morocco): epidemiological profile and antibiotic resistance
Authors: Yacoubi Loubna , Farih Soumia , Seddari Abderazzak , Benhamza Noussaiba , Aarab Adnane , maleb Adil
Published: November 2021

The objective of our study was to describe the epidemiological profile of blood culture isolates in the neonatology - neonatal intensive care unit of the Mohammed VI University Hospital of Oujda (Morocco) and to specify the resistance profile of the main germs isolated to antibiotics .This is a retrospective and descriptive study of 21 months from December 14, 2016 to September 14, 2018 and covering all positive blood cultures processed in the microbiology laboratory in accordance with REMIC (reference in medical microbiology) and EUCAST (European Committee on Antimicrobial Susceptibility Testing).contaminated blood cultures were excluded. As results, we collected 275 positive blood cultures. They occurred in the context of intravascular device (IVD) use in 59% (n=162) of cases. The most isolated bacterial groups were coagulase-negative staphylococci (CNS) 41.45 %( n=114), followed by Enterobacteriaceae 32.36 %( n=89).CNS were resistant to all beta-lactams in 57.89 %( n=66), and to glycopeptides in 5.26 %( n=6). Enterobacteriaceae were producers of extended-spectrum betalactamases in 79.77% (n=71) and producers of carbapenemases in 13.48% (n=12) of cases. The alarming increase of enterobacteriaceae isolates and their antibiotic resistance rates should encourage the reinforcement of hygiene measures in our University Hospital.
Impact of containment following COVID -19 on hospitalization activities in the pediatric surgical emergencies department, children’s hospital of Rabat
Authors: Aqqaoui Loubna , Lafia Toualouth , Skiredj Aya , Boughaleb Fadwa , Dalero Omar , Zerhouni Hicham , Ettayebi Fouad , Lebar Souad , Oubejja Houda
Published: November 2021

The Covid-19 pandemic has put stress on the healthcare system with a major impact on access to healthcare. The aim is to study the impact of containment on the hospitalization of children in the pediatric surgical emergency department, Children’s Hospital of Rabat. Material and methods: A retrospective study was carried out of children admitted at the Pediatric Surgical Emergencies Department (PSE), over a period of 6 months. The data were entered and analyzed by statistical software Jamovi 1.6.23. A chi-square test was used to compare the variables between the two periods: before and during containment. Results: We identified 579 children hospitalized during the first semester of 2020. The median age was 5 years [1-10] with predominance of boys (66.1%). Admission diagnosis are represented by abdominal emergencies (36.8%), head trauma (22.6%). Burns represent only 5,7%. These diagnosis were divided into visceral surgical emergencies (42%), trauma emergencies (48%) and non-urgent pathologies (10%). Surgery was done in 45.6%. Visceral and trauma emergencies were equivalent before and during the containment. On the other hand, there was a slight increase for visceral emergencies (57% Vs 43%) while the number of scheduled patients fell from 94.3% before containment to 5,7% during the containment.
Effect of nutritional factors on urinary calcium excretion in a sample of Moroccan children and adolescents
Authors: Bouziani Amina , Benkirane Hasnae , Idrissi Mohamed , Bajit Habiba , Ait Lachguer Sara , Guennoun Yasmine , Bouhamida Meryem , Saeid Naima , Aguenaou Hassan
Published: November 2021

In addition to age, gender, body weight, hormonal status as well as certain physiological and pathological states, other factors exert considerable effects on calcium (Ca) retention and therefore on its urinary excretion. Among these other factors, many dietary nutrients have all been discussed as factors affecting urinary Ca through different studies. Thus, our study aims to evaluate the impact of various nutritional factors on urinary Ca excretion among a sample of Moroccan children and adolescents aged from 6 to 18 years old. A total of 133 Moroccan children and adolescents aged between 6 and 18 years were involved in this study. Participants were required from public and private schools in Rabat-Salé-Kenitra region. For each participant, anthropometry data, food record and 24-h urine samples were collected. Urinary Ca was estimated using ICP-mass spectrometry. The urinary Ca average was 73.58±37.13 mg/day. Urinary Ca excretion had no significant association (p>0.05) with different studied nutrients (r=-0.082, r=0.118, r=-0.025, r=0.142, r=0.084, r=0.119 for Ca, proteins, vitamin D, sodium, phosphorus and magnesium intakes respectively).The current impact evaluation of various nutritional factors on urinary Ca excretion suggests that Ca requirement may be not influenced by nutrients intake but it is highly recommended for researchers to carry out more studies and define all factors that cause Ca deficiency in Moroccan children and adolescents.
Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016
Authors: Kharbouch Donia , Sefiani Houda , Nabih Zineb , Coulibaly Sanou Khô , Diallo Tidiane , Soulaymani Abdelmajid , Mokhtari Abdelrhani , Bencheikh Rachida Soulaymani
Published: November 2021

Analyzing the spontaneous reports of adverse drug reactions (ADRs) of anti-infective drugs for systemic use is an essential pillar in creating valuable database in pharmacovigilance.Therefore, the main of this study is to describe the epidemiological and clinical properties, as well as, the frequency and profile of ADRs generated by anti-infective treatment, declared at the Moroccan Anti-Poison and Pharmacovigilance Center (MAPPC).A retrospective descriptive study was implemented from the notifications of ADRs generated between 2008 and 2016 and recorded on VIGIBASE. Over the research period, 1161 cases of ADRs reports were declared. The average age was 37.4 years ± 19.52, it’s been noticed that the adults were the most affected in 81.89% of the total cases, with the sex ratio (Female / Male) being 1.34. Antimycobacterials and antibacterials for systemic use were responsible for 68% and 28.3% of the adverse reactions, respectively. 29.76% of the cases showcased skin and subcutaneous tissue disorders and 23.23% of the cases displayed hepatobiliary and pancreatic system disorders. Serious cases represented 30% of all noted cases, including 2 fatalities. In the interest of preventing the risk of adverse reactions originating from the taking anti-infective drugs for systemic use, reporting to the ADRs to the pharmacovigilance system should be highly encouraged.
Toxicovigilance: the misuse of psychotropic drugs in Morocco. Results of a survey conducted in Casablanca
Authors: Moussadak Abdelouahab , Farhane Hamid , Benaji Brahim , Bouzoubaa Hind , Houti Imad , El Omari Fatima , Toufiq Jallal , Aadil Nadia
Published: November 2021

In Morocco, there are very few studies on the use of drugs and even less on psychotropic medicines (MPSYC). In this study we identified the misuse of MPSYC and their sources of supply in order to determine their modes of consumption and also assess the consumers health status. Methods. An anonymous survey of 500 MPSYC consumers was conducted in Casablanca. Data entry and statistical analysis were carried out using SPSS 25.0 software.Results: 500 participants in the survey were poly-drug users of MPSYC with an average of 4.13 ± 0.007 (± SEM) drugs per user. The most misused MPSYC are Clonazepam, Diazepam, Nordazepam and Tramadol with respective prevalences of 96.80%, 82%, 55.60% and 47.80%. A statistical analysis showed that clonazepam (p=0.047) and tramadol (p=0.005) are prevalent in the street market. 54.20% of survey participants use MPSYC once a week while 39.80% of them use it twice a week. The same statistical analysis revealed that taking several MPSYC lead to an increase of ingested doses (p<0.001) and alcohol consumption (p=0.003). 96.40% (n=482) of the participants declared that they had experienced discomfort misusing the medicine.
Selection and valorization of arbuscular mycorrhizal fungi isolated from phosphate sludge basins in promoting of citrus and carob seedlings
Authors: Baiz Zakaria , Elguilli Mohammed , Azim Khalid , Dahmani Jamila , Abbas Younes
Published: November 2021

Accumulation of phosphate sludge (PS) generated from phosphate treatment process in the open air represent an environment risk and a problem in terms of storage capacities. The use of this by-products in agriculture, is an alternative recovery technique for the phosphate. Moreover, selection of symbionts and their inoculation into the soil whether in the nursery or at field were strongly encouraged. These inoculants were selected not only for their impact on the plant, but also for their ability to persist in the soil at the expense of the residual native microﬂora. This can be performed to the microorganisms which could occur in the solid sludges deriving the exploitation of phosphates in a pilot site of Khouribga area. In this context, the indigenous mycorrhizal resources have been exploited through better exploration of the local floristic diversity and then a series of mycorrhizal fungi selection and production tests have been made. The mycorrhizal complex was prepared and their effect was tested in Citrus and carob plants growth in the nursery. Two mixtures of PS were carried out: 10% (S2) and 40% (S5) for Citrus plants and 20% (S3) and 40% (S5) for carob plants. The sandy soil of Maamora forest was used as a control (S1). The results shown three dominant morphotypes were detected: Rhizophagus irregularis, Funnileformis constrictum and Scutellospora calospora. The effect of the PS with the AMF-based inoculum indicate that mycorrhizal inoculation of the substrates by a raw inoculum stimulates the growth of plants specially S2, S5 and S3 for Citrus volkameriana, Carrizo citrange and carob respectively. Based on these results, this combination between PS and mycorrhizal fungi had a great effect on Citrus and carob plant in the nursery.
Contribution of Collaborative Filtering Approach on Environmental Big Data Analytics Context
Authors: Salma Abarou , Abdellatif El Abderrahmani , Khalid Satori
Published: November 2021

In recent years and following the spread of internet using, the way of life in our society as well as the management of the main production sectors have changed towards digitalization (E-Commerce, E-Surgery, road traffic management, etc.) to minimize the. This change challenged researchers and organizations to come up with solutions to manage, maintain, classify and make the best decision from the gigantic flows of data created daily while reducing environmental Damage (Consumption of Energical resources….), From which was born the Collaborative filtering approach which facilitate decision making based on the experience feedback of Internet users. This approach is used generally the big Data Analytics Algorithm to predict and classify data
Public health monitoring using Geographic Information Systems: case viral hepatitis E
Authors: Hajar El Omari , Chahlaoui Abdelkader , Khadija Ouarrak , Kharroubi Adel
Published: November 2021

Among the major parasitic diseases having major health and socio-economic impacts in the world and in Morocco, are viral hepatitis. These are acute inflammations of the liver caused by a virus. The 3 most frequently encountered viruses are viruses A, B, C. The objective of this study is to map health events, in our case the incidence of viral hepatitis E in the different prefectures of the region of Meknes-Fez by creating a database containing geographic and health parameters in geographic information system (GIS). This database was then used to create the risk map which identifies the high-risk prefectures.

This study shows that the average incidence of viral hepatitis H is higher in the prefecture of Meknes during all the years of the study, with a high risk compared to other prefectures and provinces which have an average risk. Indeed, the mapping of health events is a descriptive tool implemented to evaluate the spatial disparities of incidence, which allowed us to perform a spatio-temporal analysis of the epidemic.

Spatial technologies, such as geographic information systems (GIS), offer a new option for disease prevention, predicting risk locations based on factors favoring the emergence or re-emergence of the epidemic.
Development and implementation of a system for medical devices monitoring in Morocco
Authors: Qouhafa Meryem , Benaji Brahim , Lebbar Souad , Soulaymani Abdelmajid , Moukhtari Abdelrhani
Published: November 2021

Given the importance of medical devices in improving health, a system of monitoring their use is necessary to ensure an acceptable benefit/risk ratio. The present study focuses on the post-marketing monitoring system, of which the aimis to develop, a national strategy for the establishment of a multidimensional vigilance system to monitor medical devices in Morocco.

Methods : The study is based on a systemic review selected by the PRISMA method for the period between [2011-2021] and on the Scopus, Pubmed, Science direct and Web of science databases.

Results: A preliminary analysis of the data identified some challenges such as under-reporting and lack of standardization of adverse reaction coding, standard nomenclature problem for international trade, lack of clarity of requirements for manufacturers, and insufficient regulation and significant incentives for the use of unique device identifiers. Recommendations for a more effective national system are put for ward which address the regulation and computerization of the system for the development of medical devices monitoring mechanisms.
Factors associated with exclusive breastfeeding practices in the commune of Sakété, southern Benin: a cross-sectional study
Authors: Amoussa Hounkpatin Waliou , Bodjrenou Sam , Baba-Ode Maryline , Lokonon Jaurès , Vissoh Sosthene , Agassounon Célestin , Alaofe Halimatou
Published: November 2021

The purpose of this study was to determine the factors associated with exclusive breastfeeding (EBF) practices in community settings of southern Benin. We conducted a quantitative and qualitative cross-sectional study in Sakété commune. Six midwives and 100 breastfeeding women with at least one child under 6 months of age completed a semi-structured questionnaire. We also conducted focus groups with grandmothers. The quantitative data were analyzed with SPSS 20 using chi-square tests, Student's t-tests, and logistic regression. The data from the focus groups were analyzed thematically. The Information-Education-Communication (IEC) sessions on the EBF were conducted in all the visited maternity care facilities. Nonetheless, only 58% of breastfeeding mothers followed EBF practices, and most grandmothers did not follow EBF practices. Regression analysis identified that mothers who participated in IEC sessions focused on good infant feeding and nutrition practices and those seeking advice from close relatives were more likely to use EBF. The study revealed a low EBF rate and suggested that interventions could educate mothers and other household members on the importance of timely breastfeeding initiation in the study area.
Using in vitro tensile strength test to monitoring quality and effectiveness of suture in the oral environment
Authors: Lashab Hajar , Benaji Brahim , Sbitti A. , Lahrache Nabil , Malha Mustapha , Meddah Bouchra , Ameziane Rachida
Published: November 2021

Sutures are medical devices used in surgery. They serve as tissues stabilizers in contact with or near to the surgical site without compromising the healing process. They must keep their physical properties for the necessary time, in particular tensile strength. In view of the wide variety of references offered by all specialtys combined, which supply sutures with all materials described, whose use is indicated for all surgical procedures. The objective of this work is to evaluate the tensile strength of absorbable and non-absorbable sutures for a period of 10 to 28 days under conditions simulated by the oral route. 5 sutures materials were tested with a metric diameter of 1.5 and 4.The tensile strength test was used according to the protocol of the European Pharmacopoeia (Eur.Ph.9.5). 5 fragments of each material were measured before and after their immersion in Artificial Saliva (AS). In AS, the Polypropylene suture significantly maintained (p = 5%) its tensile strength compared to that of Polyamide. For absorbable sutures, a loss of more than 70% of their initial strength was marked on the 7th day of immersion. In view of the results obtained, during oral surgical operations, the material of choice is in favor of Propylene.
Evaluation of the bacteriological and physicochemical risk of hospital effluents: case of the Mohamed V hospital in Meknes
Authors: Bouzid Jawad , Jaouhar Samira , Zaid Abdelhamid , Bouhlou Loubna , Chahlaoui Abdelkader
Published: November 2021

Like other countries, Morocco is committed to protecting environment. One of the actions is Law 28 00 on waste because it is harmful to environment and to health. However, hospital effluents are getting out of hand. This study looked at those at Mohamed V Hospital, which serves a population of almost 2 million people. The methodology relates to physicochemical and bacteriological analyzes of representative samples of these effluents by monthly samples over a period of one year. These were carried out in front of the four wings of the hospital between 11 a.m. and noon (maximum activity period). The search for bacteria of medical interest was carried out at the medical analysis laboratory of the Mohamed V hospital. The bacterial count as well as the physicochemical analyzes were carried out at the drinking water & wastewater pollution control laboratory of the Autonomous Distribution Authority of Water and Electricity of Meknes and of the environment and health laboratory of the Faculty of Sciences of Meknes. The results showed that some parameters correlate with others and that these effluents pose a threat to the environment and to health. Indeed, the chemical pollution values are high (NH4 +, NO2-, NO3-) compared to WHO standards. The presence of pathogenic germs is demonstrated such as pseudomonas, acinetobacter, clostridium, staphylococcus and streptococcus. On the other hand, these effluents are biodegradable since the COD / DBOS ratio varies between 1.1 and 2 (<2).
Study of the Efficiency of Two Antipyrenes for the Creation of Fireproof Polymeric Composite Materials
Authors: Barbot’ko Sergey , Bochenkov Mikhail , Volniy Oleg , Korobeinichev Oleg , Shmakov Andrei , Sivenkov Andrei , Babikova Anastasiia
Published: November 2021

Most of polymeric materials, when exposed to high temperatures, heat flows or an open flame, are capable of exothermic oxidation reactions – combustion. That is why polymeric materials are fire hazardous. The studies on creating a non-flammable polymer materials are crucial, as such products can make our everyday life a lot more safe. Studies have been carried out to assess the effectiveness of the action of two types of fire retardants (graphene and an organic phosphorus-containing compound DOPO-THPO), introduced into an epoxy resin. Evaluation of the effectiveness of the fire-retardant action was carried out by the methods of oxygen index (OI) and flammability according to UL 94. For the investigated compositions, it was found that there is no direct correlation between the value of the oxygen index and the ability of the samples to maintain self-combustion. For these compositions, the total duration of residual combustion in vertical tests and the speed of flame propagation in horizontal tests are naturally correlated. It was found that if the total duration of combustion of five samples during vertical tests is 500 seconds or less, then these compositions during horizontal tests will fade, that is, formally, their flame propagation speed will be equal to zero.
Air Injection as a Solution to the Problem for Reducing High-Frequency Acoustic Noise in Some Operating Modes of Francis Hydro Turbines
Authors: Dolmatov E. N. , Ilin S. Y. , Eliferov V. V.
Published: November 2021

During operation of Francis hydro turbines at the regimes of 70–95 % of Nrated, high-frequency acoustic phenomena (noise) were recorded. In order to study and identify the causes of these phenomena, special field tests were conducted. The main objectives of the tests were: determination of the main frequencies of acoustic phenomena, comparison with natural frequencies of the turbine water passages elements and the search for solutions to reduce acoustic phenomena. During the tests, the natural frequencies of the elements of turbine water path were investigated. Several methods of air injection to the turbine water path were also tested. The most effective way (including by the amount of air) to reduce acoustic phenomena was the air injection from industrial air piping into the spiral case and into the area of guide vanes.
Comparison of Jet Pump Numerical Calculation Results in ANSYS and Openfoam CFD Packages
Authors: Klyuyev A. S. , Chernyshev Y. I. , Ivanov E. A. , Borshchev I. O.
Published: November 2021

Currently, among the most popular computational fluid dynamics software packages are commercial CFD packages – ANSYS CFX, ANSYS Fluent, STAR-CCM+ and several others. In contrast to the above-mentioned commercial CFD packages, there is an OpenFOAM, a non-commercial, freely distributed, integrated platform for numerical modeling of solid-state mechanics tasks (including CFD tasks), and it is becoming more and more popular. In addition to being a non-commercial package, OpenFOAM also has open-source code, which allows users to write their own algorithms for solving highly specialized tasks. A comparison of ANSYS and OpenFOAM in the application to CFD problems of incompressible turbulent flow in this article is given by the example of jet pump calculation, which was tested in the Laboratory of Hydraulic Machinery of Peter the Great St.Petersburg Polytechnic University.
Glossoplastie de réduction : quelle place en 2021 ?
Authors: André Charles-Victor , Gardon Marc-Antoine , Bennaceur Selim
Published: November 2021

Les macroglossies, liées au déséquilibre entre le volume de la langue et son environnement, ne sont pas sans conséquences fonctionnelle, occlusale, phonatoire, respiratoire ou esthétique.

Si l’efficacité de la glossoplastie de réduction a été démontrée depuis de nombreuses années, certaines séquelles fonctionnelles, sensorielles et esthétiques l’ont écartée de l’arsenal thérapeutique. Au travers de cet article, nous revenons sur les principales indications et décrivons une technique chirurgicale au préjudice très limité, nous permettant de conserver ce geste dans nos plans de traitement.
Pollinosis, allergisches Asthma bronchiale, Nuchalgie
Authors: Peuker Elmar T.
Published: November 2021

Der nachstehende Fall beschreibt die Akupunkturbehandlung bei einer Patientin,
die aufgrund einer Allergie gegen Pollen unter einer starken Rhinitis und
Konjunktivitis allergica sowie einer beginnend allergisch-asthmatischen
Entwicklung litt. Darüber hinaus bestanden Nuchalgien mit okzipitaler
Ausstrahlung.
Diagnostik und Therapie von Asthma bronchiale aus Sicht der
TCM
Authors: Wullinger Michael
Published: November 2021

Die Behandlung von asthmatischen Beschwerden wurde in der Literatur der
Chinesischen Medizin bereits vor ca. 2000 Jahren beschrieben. Einige dieser
alten Rezepturen sind klinisch auch in der heutigen Zeit hoch wirksam. In
neuerer Zeit mehren sich auch in randomisierten Studien Hinweise für die
Wirksamkeit von Akupunktur und chinesischer Arzneimitteltherapie (CAT) bei der
Behandlung von Asthma. Im nachfolgenden Artikel werden zunächst
grundlegende Besonderheiten von Asthma in der TCM dargestellt. Daraufhin werden
die energetische Differenzierung und die Therapie mit Akupunktur und
chinesischer Arzneimitteltherapie beschrieben. Abschließend wird der
Stellenwert der verschiedenen Behandlungsverfahren bei der Therapie
bewertet.
Göttermantel für die Haut
Authors: Huber Ellen
Published: November 2021

Seit Menschengedenken wird die Eichenrinde bei Erkrankungen der Haut und Schleimhaut eingesetzt.
Vector–host epidemic model with direct transmission in random environment
Authors: Son Hyunjin , Denu Dawit
Published: November 2021

This paper studies a stochastic vector–host epidemic model with direct transmission in random environment, governed by a system of stochastic differential equations with regime-switching diffusion. We first examine the existence and uniqueness of a positive global solution. Then, we investigate stability properties of the solution, including almost sure and pth moment exponential stability and stochastic asymptotic stability. Moreover, we study conditions for the existence and uniqueness of a stationary distribution. Numerical simulations are presented to illustrate the theoretical results.
Adaptive compound control based on generalized Bouc–Wen inverse hysteresis modeling in piezoelectric actuators
Authors: Zhang Quan , Gao Yuanpeng , Li Qingling , Yin Dayi
Published: November 2021

This paper focuses on the study of the dynamic hysteresis compensation and control of piezoelectric actuators so as to improve the swing accuracy of the piezoelectric fast steering mirror mechanism in the photoelectric compound-axis control system. Moreover, in view of the rate dependence and asymmetry of piezoelectric hysteresis, and the complex inversion process of the generalized Bouc–Wen hysteresis model, the Hammerstein dynamic inverse hysteresis model of the piezoelectric actuator is established. To be specific, the static nonlinearity and rate dependence of the piezoelectric inverse hysteresis are represented by the generalized Bouc–Wen inverse model and the auto-regressive exogenous model, respectively, and the parameters of the model are identified by the adaptive beetle swarm optimization algorithm. In the process of the open-loop feedforward compensation, the dynamic positioning accuracy of the piezoelectric actuator is greatly affected by various disturbances and the uncertainty of the hysteresis compensation model. In this context, a compound control strategy that combines the feedforward compensation with the single-neuron adaptive proportion-integration-differentiation control is proposed based on the Hammerstein dynamic inverse hysteresis model of the piezoelectric actuator. The experimental results verify the effectiveness and superiority of the proposed control strategy.
Probing the ultrafast gain and refractive index dynamics of a VECSEL
Authors: Kriso C. , Bergmeier T. , Giannini N. , Albrecht A. R. , Sheik-Bahae M. , Benis S. , Faryadras S. , Van Stryland E. W. , Hagan D. J. , Koch M. , Mette G. , Rahimi-Iman A.
Published: November 2021

Typically, strong gain saturation and gain dynamics play a crucial role in semiconductor laser mode-locking. While there have been several investigations of the ultrafast gain dynamics in vertical-external-cavity surface-emitting lasers (VECSELs), little is known about the associated refractive index changes. Yet, such refractive index changes do not only have a profound impact on the pulse formation process leading to self-phase modulation, which needs to be compensated by dispersion, but they are also of particular relevance for assessing the feasibility of Kerr-lens mode-locking of VECSELs. Here, we measure both refractive index as well as gain dynamics of a VECSEL chip using the ultrafast beam deflection method. We find that, in contrast to the gain dynamics, the refractive index dynamics is dominated by an instantaneous (∼100 fs) and a very slow component (∼100 ps). The time-resolved measurement of nonlinear refraction allows us to predict a pulse-length dependent, effective nonlinear refractive index n2,eff, which is shown to be negative and on the order of 10−16m2/W for short pulse lengths (∼100 fs). It becomes positive for large excitation fluences and large pulse lengths (few ps). These results agree with some previous reports of self-mode-locked VECSELs for which the cavity design and pulse properties determine sign and strength of the nonlinear refractive index when assuming Kerr-lens mode-locking.
Spatio-temporal dynamics and disintegration of a fan liquid sheet
Authors: Broumand M. , Asgarian A. , Bussmann M. , Chattopadhyay K. , Thomson M. J.
Published: November 2021

The dynamic behavior and disintegration mechanisms of a fan liquid sheet in a quiescent atmosphere are investigated over a broad range of differential injection pressures up to Δp≈70 bar through experiments, proper orthogonal decomposition (POD) and spectral analyses, and linear stability analysis (LSA). By fan liquid sheet, we mean a diverging and attenuating liquid stream emanating from a flat fan nozzle with high velocity. High spatiotemporal resolution backlit images reveal the formation-growth-fragmentation process of bag-like structures along the fan liquid sheets, which we predict to be responsible for the overall breakup of the sheets through a mechanism known as “wavy corridor.” Therefore, we propose a conjugate model based on LSA to take into account the role of different shear and surface tension-driven instabilities in defining the liquid sheet intact radius and primary droplet sizes. The predictions of LSA from the dynamic features of the liquid sheets, which mainly depend on the sheet Weber number We, are consistent with the quantitative results obtained from the POD and spectral analyses of the images. While the Strouhal number St and the intact radius R of the fan liquid sheets reduce like We−1/3 with increasing We, the volume median diameter of primary droplets decreases like We−11/12. An image feature consolidation technique along with a machine-learning technique, receiver operating characteristic curve analysis, was used to estimate the mean diameter of spray droplets with a large range of sizes.