bluuebunny/crossref_metadata_2025 huggingface dataset:
Priming Bean Seedlings to Boost Natural Plant Defenses Against Common Bacterial Wilt: Gas Exchange, and Fluorescence Results (Part 2)
Authors: Ramsey Craig L. , Sandoval Vanessa M. , Freebury Paul C. , Newman Debra H. , Dooley Greg , Cseke Leland J. , Newman Steven E.
Published: May 2023

This greenhouse study evaluated the effects of two chemical primers for kidney bean seedlings against a bacterial wilt (Curtobacterium flaccumfaciens pv. Flaccumfaciens) (CFF). The premise of this study was that the oxidant primers would mimic the signaling properties of radical oxygen species and initiate a cascade of molecular defenses. The factorial study included two levels for the foliar chlorine dioxide treatment, and two levels for the bacterial wilt inoculation treatment, plus two supplemental chemical treatments. The foliage response variables were gas exchange and fluorescence. There was a 36, 154, and 70% reduction in Pn, gs, and E, respectively, at 39 DAT when comparing the inoculated control to the non-inoculated control. The chlorine dioxide primers lowered leaf temperatures and leaf vapor pressure deficit in the CFF wilt inoculated plants. The chlorine dioxide primers improved gas exchange at 39 DAT when compared to the water treatments. Part 1 and 2 of this series conclude that the chlorine dioxide primers can activate a long-term, systemic acquired resistance (SAR) response in kidney bean plants infected with the CFF wilt. The Part 2 article also concludes that the EB treatments caused several inexplicable correlations among the gas exchange responses. A structured water premise was proposed as an explanation for the gas exchange anomalies due to the EB treatments. Intuitively, this study suggests that chlorine dioxide primers can initiate a series of ROS and salicylic acid signals that activate a suite of mechanisms that provide universal, multifaceted plant immunity that is sustained across a crop season.
“To Whom He Did Not Do!”: Alexander Pavlovich Ivanov in the circle of Dostoevskys
Authors: Davletbaeva Varvara , Emchenko Elena  Emchenko
Published: May 2023

The building of the former Konstantinovsky Boundary Institute, preserved on Old Basmannaya Street, is a memorable Moscow location associated with the name of Dostoevsky. The writer often stayed and lived here, thanks to his close relationship with the family of his sister Vera Mikhailovna Ivanova. They were formed not only because of his sister, but primarily owing to her husband Alexander Pavlovich Ivanov, a doctor and teacher at the Surveying Institute. A. P. Ivanov was distinguished by high moral qualities, incredible kindness, generosity, excellent education, dedication to medical and pedagogical service. These qualities of the writer’s brother-in-law are acknowledged not only in the letters of Dostoevsky, whom A. P. Ivanov helped during difficult periods of his life, but also in the famous memoirs of A. M. and A. G. Dostoevsky’s, N. Von Focht, and M. A. Ivanova. The article presents the data from A. P. Ivanov’s record of service for 1847, 1848, 1854, 1867 and 1868, allowing to trace his career growth and professional duties. The living image of a motivated student of the medical faculty of Moscow University, A. P. Ivanov, is drawn by the forgotten memoirs of his classmate M. V. Tolstoy, published in 1881. The significance of the “long-term and useful service” of the doctor and teacher of the Boundary Institute for students and the entire staff of the educational institution is reflected in the little-known memoirs about him by A. L. Apukhtin, the director of this educational institution, which were used in this study.
The Islamization of Science and Its Consequences: An Examination of Ismail Raji Al-Faruqi's Ideas
Authors: Sawaluddin Sawaluddin , Harahap Koiy Sahbudin , Rido Imran , Supriono Iwan Agus
Published: May 2023

This research is motivated by the advancement of science, which has varied effects on human life and the environment. Science, on the one hand, can help and reduce human burdens, but it also contributes to the destruction of human values, and even self-existence. Western science, which is secular in nature, is founded on the concepts of materialism, naturalism, and existentialism, producing information that is divorced from spiritual and moral values. As a result, Islamic scholars believe that the Islamization of science must be formalized. The goal of this research was to learn about Ismail Raji Al-Faruqi's concept of Islamization of Science. The literature study approach was employed in this study, which involved examining journals, books, research reports, periodicals, and other publications. According to the findings of this study, al-Faruqi is a figure with excellent ideas for resolving people's issues. The concept of education is inextricably linked to the concept of monotheism, which became known as the Islamization of knowledge. Islamization is accomplished by a process of rationalization and sacralization of knowledge, as well as through the integration of Western and Islamic science. Al-Faruqi's ideas contribute to the intellectual development of Muslim civilization by integrating Islamic moral standards with modern education, giving rise to intellectuals all over the world, including in Indonesia.
The Changing Roles of Ulama and the Evolution of Islamic Schools: Some Insights from Moroccan and Indonesian Cases
Authors: Ridwan Auliya
Published: May 2023

The ulama, who are scholars in the Islamic tradition, play a vital role in preserving the prophet's teachings and passing them down to future generations. In addition to this, they also have other important social functions. The combination of religious and social roles within the ulama allows them to influence social change with religious legitimacy. This article explores how the social roles of the ulama have evolved over time and how this has impacted the existence of Islamic schools. To illustrate this, examples are drawn from the literature on Morocco and Indonesia during the 20th and 21st centuries. During the colonial period in Morocco, the ulama and Islamic schools served as a cultural defense against French colonial influence. Meanwhile, in Indonesia, Islamic schools led by Ulama became the foundation of the Muslim resistance movement against Dutch colonial rule. In both cases, Islamic scholars and schools demonstrated their ability to respond to actual social situations, highlighting their cultural power and importance in society.
Information Technology Governance in Colombian Small and Medium Companies: An Exploratory Study Using Data Analysis
Authors: Trujillo-Lambert Yeni , Osorio Sanabria Mariutsi , Maestre-Gongora Gina , Astudillo Hernan
Published: May 2023

Information Technology (IT) is a resource for achieving strategic business objectives. However, many Small and Medium-sized Enterprises (SME’s) do not consider IT a strategic area. This article explores the perception of IT governance in Colombia among IT professionals. It presents the design, data analysis, and results of a survey based on the Governance of Enterprise IT framework. The survey was conducted in 2019 and 2020, obtaining responses from 151 IT professionals that worked in 48 SME's and 90 from large companies. Data were analyzed with WEKA and KNIME, applying classification, segmentation, and association techniques. Results indicate that: (1) SME’s associate IT investment with the generation and improvement of products and services; (2) employees’ and users’ performance is higher when they work in companies with managers that have a high commitment to IT governance; and (3) 95% of companies with high implementation levels of IT governance consider IT very important in their strategies.
Autism, faith and churches: The research landscape and where we go next
Authors: Waldock Krysia Emily , Sango Precious Nonye
Published: May 2023

Although there is a growing field exploring Autistic people, faith and churches, negative attitudes remain towards Autistic people within some faith spaces. Our paper aims to unpick the theological and sociological issues behind negative attitudes, beliefs and practices. We will then tentatively suggest how this projects a neuronormative and able-bodied image of God, and hinders the flourishing of all church members, notably Autistic people. We will then reflect on the current research landscape and knowledge-to-practice pipeline in churches. Finally, we will provide some recommendations for future directions, and practical recommendations for research and practice.
Long Noncoding RNA MAGI2-AS3 Represses Cell Progression in Clear Cell Renal Cell Carcinoma by Modulating the miR-629-5p/PRDM16 Axis
Authors: Yan Chengquan , Wang Pengfei , Zhao Chaofei , Yin Guangwei , Meng Xin , Li Lin , Cai Shengyong  , Meng Bin
Published: May 2023

The objective of this study was to determine the regulatory mechanism of MAGI2-AS3 in clear cell renal cell carcinoma (ccRCC), thereby supplying a new insight for ccRCC treatment. Expression data in TCGA-KIRC were obtained. Target gene lncRNA for research was determined using expression analysis and clinical analysis. lncRNA's downstream regulatory miRNA and mRNA were predicted by bioinformatics databases. ccRCC cell malignant phenotypes were detected via CCK-8, colony formation, Transwell migration, and invasion assays. The targeting relationship between genes was assessed through dual-luciferase reporter gene analysis. Kaplan-Meier (K-M) analysis was carried out to verify the effect of MAGI2-AS3, miR-629-5p, and PRDM16 on the survival rate of ccRCC patients. MAGI2-AS3 expression in ccRCC tissue and cells was shown to be markedly decreased and its expression to continuously decline with tumor progression. MAGI2-AS3 suppresses ccRCC proliferation and migration. Dual-luciferase assay showed that MAGI2-AS3 binds miR-629-5p and that miR-629-5p binds PRDM16. In addition, functional experiments showed that MAGI2-AS3 facilitates PRDM16 expression by repressing miR-629-5p expression, thereby suppressing ccRCC cell aggression. K-M analysis showed that upregulation of either MAGI2-AS3 or PRDM16 significantly improves ccRCC patient
survival, while upregulation of miR-629-5p has no significant impact. MAGI2-AS3 sponges miR-629-5p to modulate PRDM16 to mediate ccRCC development. Meanwhile, the MAGI2-AS3/miR-629-5p/PRDM16 axis, as a regulatory pathway of ccRCC progression, may be a possible therapeutic target and prognostic indicator of ccRCC.
A study of the multi-scale compression behaviour of a sand immersed in a viscous liquid
Authors: Wang W. , Chen D. , Coop M. R. , Yuan B.
Published: May 2023

Pore fluids with different viscosities can exist in soils. While the effects of pore fluids have been investigated at the macro-scale, little is known about how they might affect the micromechanics. A novel apparatus allowing a single particle to be crushed while immersed in a liquid was built here. With the help of a high-speed microscope camera, the crushing processes of single silica sand particles immersed in glycerine were captured and the breakage modes were clarified. The immersion in glycerine leads to stronger particles with higher strains at failure compared with immersion in water or exposure to air. Moreover, the results of constant rate strain oedometer tests revealed that saturation in glycerine made the sample significantly stiffer in compression as a result of less particle breakage compared with that in water or under dry conditions. The lower particle breakage at the macro-scale appeared to correspond to the higher strengths measured at the micro-scale.
Diversity of Immersion Mechanics in Videoludic Novels
Authors: Lescouet Emmanuelle , Dumoulin Pierre Gabriel
Published: May 2023

Interactive fictions are digital narrative artworks that require little to no dexterity. Indeed, these multimedia fictions do not require a particular proficiency in their manipulation to access and explore the story. However, they do demand distinct mechanics and reading moves, specific to narrative models. These items, between literary and videogame studies, call for the analyses of their own modes of interaction and consumption. In this specific environment, reading, as a form of entertainment, is voluntary and engaged. Since there is a tacit contract with the work that the reader agrees to, which establish the expectation horizon and convey reading habits, our study qualifies this reading experience as immersion, plunging into a second world, and exploring the possibilities it offered. In this article, immersion is defined as an entertainment experience where the human subjects get lost inside the text, they are incorporated in it. They find themselves in the narrative and feelsits affects. We must therefore consider a continuum between artworks relying onfew interactions –even minimal and repeated actions– and others that require more complex sequences. Les fictions interactives sont des œuvres d'art narratives numériques qui ne requièrent que peu ou pas de dextérité. En effet, ces fictions multimédias ne requièrent pas de compétences particulières dans leur manipulation pour accéder à l'histoire et l'explorer. Cependant, ils exigent des mécanismes et des mouvements de lecture distincts, propres aux modèles narratifs. Ces éléments, entre études littéraires et études vidéoludiques, appellent à l'analyse de leurs propres modes d'interaction et de consommation. Dans cet environnement spécifique, la lecture, en tant que forme de divertissement, est volontaire et engagée. Puisqu'il existe un contrat tacite avec l'œuvre que le lecteur accepte, qui établit l'horizon d'attente et transmet des habitudes de lecture, notre étude qualifie cette expérience de lecture d'immersion, de plongée dans un second monde, et d'exploration des possibilités qu'il offre. Dans cet article, l'immersion est définie comme une expérience de divertissement où les sujets humains se perdent dans le texte, ils y sont incorporés. Ils se retrouvent dans le récit et en ressentent les effets. Nous devons donc considérer un continuum entre les œuvres d'art reposant sur peu d'interactions - même des actions minimales et répétées - et d'autres qui requièrent des séquences plus complexes.
“It’s easy to just be normal”: Performative masculinities in Die stropers
Authors: Boshoff Danel , Conradie Annemi
Published: May 2023

In post-apartheid South Africa, the representation of queer identities in Afrikaans-language films have become increasingly prominent. However, many such films focus on past contexts or serve as comedic depictions, failing to confront the complex issues faced by individuals in contemporary Afrikaner communities. Etienne Kallos’s 2018 coming-of-age film Die stropers (The Harvesters) candidly depicts the challenges faced by adoptive brothers Janno and Pieter, who must negotiate desire and gender in a conservative, Afrikaans farming community. Drawing on Judith Butler’s notion of gender performativity and recent reformulations of Raewyn Connell’s notion of hegemonic masculinity, we examine the discursive (re)production of hegemonic Afrikaner masculinity within the boys’ adoptive family and community. We investigate how the protagonists strategically deploy performative masculinities to achieve belonging and acceptance as heirs, even if the ideals they emulate oppress and restrict them. We propose that the protagonists’ strategic deployment of performative masculinities represents their claiming of agency in contexts where gender and desire are aggressively policed. Furthermore, their navigation of hegemony in this white, Afrikaner community through resistance and consent might point to a claiming of space for queer identities and the continued transmutation of hegemonic masculinity.
The fractal analysis - Powerful tool for geodynamic investigations
Authors: Boyko Ranguelov
Published: May 2023

This is a short review of fractal analysis applications in Bulgaria to investigate the geodynamics at the local, regional, and global levels.
AAV viral DNA and whole RNA recovery for AAV pool experiments in rhesus macaque v1
Authors: Chuapoco Miguel
Published: May 2023

This protocol outlines procedures to extract viral DNA and whole RNA from rhesus macaque tissue that had been treated with AAV in vivo
Extraction of 1-HP derivatives and HPLC preparation v1
Authors: Zaka Asif Muhammad
Published: May 2023

This protocol describes day 6 of our workflow to grow worms in liquid culture to induce the production of natural products (in this case, 1-HP derivatives). In this protocol, we extract 1-HP and its derivatives and then prepare the sample for HPLC injection.
CD34+ Cell RNP Nucleofection v1
Authors: A Kuppers Daniel
Published: May 2023

Human CD34+hematopoietic stem and progenitor cells (HSPCs) are a standard source of cells for clinical HSC transplantations as well as experimental xenotransplantation to generate “humanized mice”. To further extend the range of applications of these humanized mice, we developed a protocol to efficiently edit the genomes of human CD34+HSPCs before transplantation. We have optimized nucleofection of sgRNA:Cas9 ribonucleoprotein complexes and are now able to edit a candidate gene in CD34+HSPCs with almost 100% efficiency, and without affecting their potential for engraftment and multilineage differentiation in mice.
Fully Remote Software Development as a New Standard in the IT Industry: European Study 2022—2023
Authors:   Moscow, 125368, Russian Federation, Pashchenko D. S.
Published: May 2023

The pandemic and the emergence of the COVID-economy continue to have a significant impact on the organization of labor in the industries of the "new economy", of which the information technology industry is a prominent representative. By 2023, a significant number of Russian, European and global IT corporations and small software companies are working in a completely remote mode — outside the offices and without personal meetings of employees even within the same software development team. This article presents the results of a European study (Dec. 2022 — Jan. 2023), covering the experience of 48 software development and IT support teams in companies headquartered in Europe: Yandex, Sberbank, VTB to Deutsche Bank, ATOS IT, Finastra, etc. The experts determined the level of demand for new organizational and production paradigms in software development and presented their ideas and forecasts on the development of fully remote software development as a new IT industry standard in the medium term 2023—2024. The results of the study are presented in the form of solving the relevant research problems and testing the hypotheses about the level of consolidation of new paradigms in the practice of leading IT companies and their impact on the corporate culture and business processes of IT companies.
Software Platform for Reading, Processing and Analyzing EEG Data
Authors:   Institute for Problems in Mechanical Engineering of the Russian Academy of Sciences, Saint-Petersburg, 199178, Russian Federation, Babbysh N. A.
Published: May 2023

Electroencephalogram (EEG) data can be used in many different areas. For example, for diagnosing brain diseases, in brain computer interfaces, for conducting various studies, and much more. To apply EEG data, a large set of different algorithms for preprocessing and analyzing these data is needed. This paper describes a software platform containing a set of tools for automated processing of EEG signals and their analysis, including machine learning methods. The platform has a flexible architecture and consists of modules, which allows it to be used for various purposes. Data can be obtained both from files and directly from the electroencephalograph device in real time. The graphical interface provides a convenient way to configure the modules of the software. The software interface of client applications (API) makes it possible to use this platform to create prototypes of devices that use EEG data for their work.
METHYLSENSITIVE COMET ASSAY: ANALYSIS OF DNA METHYLATION LEVEL IN GLIOBLASTOMA T98G CELL LINE
Authors:   Taras Shevchenko national University of Kyiv, Afanasieva Katerina , Svyrydova Kateryna ,   Taras Shevchenko national University of Kyiv
Published: May 2023

Methylsensitive comet electrophoresis is based on the assessment of the level of DNA migration from individual lysed cells after treatment with methylsensitive restriction enzymes. Using model human lymphocytes, the optimal combination of restriction intensity and electrophoresis time was selected and a new approach for evaluating the relative level of DNA methylation was proposed. It was established that in the cells of the T98G culture, which are actively proliferating, the level of methylation is higher than in cells arrested at the G1 phase of the cell cycle. At the same time, the level of DNA methylation in G1 cells of the T98G line is significantly lower compared to lymphocytes.
The Community Stress-Drop Validation Study—Part I: Source, Propagation, and Site Decomposition of Fourier Spectra
Authors: Bindi Dino , Spallarossa Daniele , Picozzi Matteo , Oth Adrien , Morasca Paola , Mayeda Kevin
Published: May 2023

As part of the community stress-drop validation study initiative, we apply a spectral decomposition approach to isolate the source spectra of 556 events occurred during the 2019 Ridgecrest sequence (Southern California). We perform multiple decompositions by introducing alternative choices for some processing and model assumptions, namely: three different S-wave window durations (i.e., 5 s, 20 s, and variable between 5 and 20 s); two attenuation models that account differently for depth dependencies; and two different site amplification constraints applied to restore uniqueness of the solution. Seismic moment and corner frequency are estimated for the Brune and Boatwright source models, and an extensive archive including source spectra, site amplifications, attenuation models, and tables with source parameters is disseminated as the main product of the present study. We also compare different approaches to measure the precision of the parameters expressed in terms of 95% confidence intervals (CIs). The CIs estimated from the asymptotic standard errors and from Monte Carlo resampling of the residual distribution show an almost one-to-one correspondence; the approach based on model selection by setting a threshold for misfit chosen with an F-ratio test is conservative compared to the approach based on the asymptotic standard errors. The uncertainty analysis is completed in the companion article in which the outcomes from this work are used to compare epistemic uncertainty with precision of the source parameters.
Израильско-украинские отношения в контексте новой геополитической ситуации
Authors: Крылов Александр , Федорченко Андрей
Published: May 2023

Геополитическая ситуация меняется на глазах и высвечивает специфическую роль израильско-украинских отношений. Исследователи представляют в статье краткий экскурс в историю этих отношений, которая насчитывает немногим более трех десятилетий, раскрывают основные аспекты двустороннего взаимодействия в политическом, социальном и экономическом измерениях; анализируют причины и проблемы, препятствующие преодолению накопившихся негативных тенденций и налаживанию полноценного сотрудничества между двумя государствами. Появившиеся в последнее время в отечественной и зарубежной прессе статьи носят преимущественно информационно-справочный характер, они акцентируют внимание в первую очередь на аспектах, связанных с нежеланием Израиля участвовать в кампании стран НАТО в полноформатной поддержке киевского режима в конфронтации с Россией. В связи с этим авторы предприняли попытку проанализировать значительную часть комплекса проблем, оказывающих ключевое влияние на алгоритм развития израильско-украинских отношений. Главный вывод исследования заключается в том, чтобы ответить на принципиально важный вопрос: почему, будучи ключевым стратегическим партнером США в регионе Ближнего Востока, Израиль, в отличие от русофобской позиции, занимаемой странами НАТО и их сателлитами, придерживаться более взвешенных и конструктивных подходов в отношении ситуации, сложившейся вокруг Украины после начала специальной военной операции?
Cheng Dieyi in Farewell My Concubine, A drag or an act? A queer or an actor?
Authors: Hongru Xing
Published: May 2023

This article reflects on the character Cheng Dieyi, highlighting the gender trouble that emerges through the corporality. From Judith Butler’s theory of gender performativity, the article attempts to propose the possible connection between the drastic shift in Dieyi’s gender identity and the repetitive and performative practices of female impersonation throughout his professional learning to be a male Dan* actor of the Beijing Opera (Jingju). Beyond a usual reading which attributes Dieyi’s suicide to psychological disorders that confuse life and performance, my hypothesis is that his gendertrouble should be understood as queerness in affective and intimate terms; thus, exposes the dynamicrelation between performance and performativity and invites reflections and criticisms about suchdynamics in Butlerian performativity.
The Birth of Sinology and the Contributions of Spain
Authors: Chunde Yan
Published: May 2023

El término “sinología” tiene su origen a finales del siglo XVII y principios del siglo XVIII. Desde entonces, innumerables misioneros se fusionaron en China sin prejuicios, lo que no solo trajo “Difusión hacia el este del aprendizaje occidental hacia China”, sino que también creó la “Difusión hacia el oeste de la cultura china al mundo”, traduciendo los clásicos culturales chinos al oeste, lo que se convirtió en la clave del nacimiento de la sinología. España es un país pionero con un próspero estudio de sinología en Europa, y su contribución ha influido mucho en la imaginación occidental de China y el nacimiento de generaciones de sinólogos. Debido a las diferencias culturales, precedentes, diferentes patrones de pensamiento y contextos culturales, las personas llegarán a diferentes conclusiones y hablarán de diferentes realidades sobre la cultura. La Sinología conecta a académicos chinos e internacionales para cumplir la misión de exploración académica en los estudios de China. Con motivo del III Congreso Internacional (3-4 de mayo de 2022) sobre Estudios de China: contacto y diálogo entre Oriente y Occidente organizado por el Instituto Confucio de la Universidad de León, el profesor Yan Chunde presentó su discurso de apertura titulado “El nacimiento de la sinología y las Aportaciones de España”, con el objetivo de resumir la historia de los estudios de sinología a través de la traducción de los clásicos chinos en diferentes épocas históricas y presentar a los lectores las aportaciones de los sinólogos españoles, concluyendo que el ser humano necesita la variedad cultural para ser inclusivos, para aprender de las fortalezas de los demás, para compensar sus propias debilidades y, finalmente, para alcanzar el criterio cultural de "lograr objetivos unificados de uno mismo con los demás, de modo que el mundo pueda armonizarse".
Texto e imagen: amistad, desenvoltura y filosofía vital en Embriaguez en el bosque otoñal de Shi Tao
Authors: Rongqiao Wu
Published: May 2023

En la tradición cultural china se establece un afectuoso vínculo entre el hombre y la naturaleza. Según la perspectiva de los antepasados, todos los objetos del universo están dotados de vitalidad. Esta filosofía de vida no solo sirve como un supremo principio estético para orientar las actividades artísticas, sino que también moldea en gran medida las características de la identidad nacional china. Este artículo intenta inquirir el espíritu humanista del paisajismo chino a la luz de la filosofía vital. Mediante un análisis semiótico y sociocultural de la “Embriaguez en el bosque otoñal” (c. 1702) de Shi Tao, el presente trabajo pretende, por una parte, descubrir las estrategias expresivas para la representación de la ebriedad en el bosque otoñal; y, por otra parte, indagar cuál es la máxima preocupación máxima detrás de los signos artísticos. De esta manera invita a reflexionar sobre un nuevo camino hermenéutico distinto al estilismo y la iconología para comprender la pintura de los literatos.
Desarrollo Sostenible de la Comunicación Lingüística: Localización e Innovación de los Institutos Confucio en España
Authors: Qiuyang Li
Published: May 2023

Como típica educación transfronteriza, el Instituto Confucio ha cumplido su función de difundir el idioma chino en todo el mundo desde su fundación en 2004. La localización del proceso de enseñanza hacia el sistema educativo y cultural regional se vuelve clave para la sostenibilidad de IC en el extranjero. Este artículo adopta una metodología cualitativa de entrevistas en profundidad entre 18 participantes que son personal administrativo y docente de las IC de España para investigar la motivación característica, el camino, el modo y la eficacia de la IC con el fin de buscar nuevas formas de resolver los problemas de posicionamiento regional, estrategia integradora y desarrollo postpandemia desde la perspectiva de la especificidad del país y la localización para la educación transfronteriza. Los hallazgos de este estudio muestran que los IC en España promueven la fertilización cruzada entre profesores de chino y español, comparten valores centrales de manera táctica a través de la cultura transnacional y fortalecen una cognición positiva entre los medios locales y los estudiantes. Para lograr la profundidad y amplitud de la localización de la educación china en España, se deben adoptar las siguientes estrategias: Centrarse en los valores económicos y culturales del idioma chino, investigar en profundidad las políticas lingüísticas locales y promover la plena integración del chino en el sistema educativo nacional español; formular las estrategias de adaptación para la localización de estándares internacionales de nivel de chino para aumentar la oferta de recursos de enseñanza de chino; comprender la situación actual de la formación del profesorado en educación china en España y ayudar a la formación del profesorado local en todos los niveles; mejorar la capacidad del servicio de precisión de la educación china internacional.
Martín de Rada’s Book Collection
Authors: Folch Dolors
Published: May 2023

This article will explore the library of the most important of the 16th century Manila based Augustinians, fray Martin de Rada, a well known cosmographer, mathematician and astronomer. After spending more than five years in Mexico, and ten in the Philippines, in 1575 he was assigned to the first Spanish expedition to China and wrote a highly influential Relación about it. From his own letters —14 of them extant—, the letters of his contemporaries about Rada —from Manila, Mexico and Spain—, and the Relación of his fellow traveler to China, Miguel de Loarca, we are able to disentangle his main intellectual interests and the contents of his library: what he wrote —both in Mexico and Asia—, the significance of the scientific works that he took with him to Asia, the importance of the Chinese maps with which he worked while in Manila —before and after his travel to China—, what books he bought in China and what use did he make of them, and the last works in which he was working before his death. This gives Rada a strong intellectual profile that has to be compared with that of his contemporary, the Jesuit Matteo Ricci.
The Practice of the “Inclusive Care Policy” of Mohism
Authors: Herranz Martín Manuel
Published: May 2023

This paper aims at contextualizing historically some parts of the Mò biàn, the dialectical part of the Mòzǐ, attributed to the later mohist school or Neo-Mohism. We will try to get a deeper understanding of two texts by linking them with the world view and circumstances of the time.Before going into those texts, first we will briefly review some aspects of today´s interpretation of the Mohist doctrine and compare the experience of the Mohism in China with its Western counterparts, the Cynic and Stoic Schools of Thought, since both shared Cosmopolitanism at the core of their doctrines. We will conclude that the circumstances preventing the implementation of Cosmopolitanism or the Universal Love policy as proposed by the mohists have been removed by the globalization allowing the possibility of this policy to be carried out.
The Belt and Road Initiative: An Opportunity for Spain
Authors: Ríos Xulio
Published: May 2023

"The Belt and Road" initiative is the most ambitious international project promoted by the current Chinese leadership. They have weighed internal and external variables in order to launch it. The project covers countries that represent 70% of the world’s population and produce 55% of the global GDP. Spain is part of the initiative, in both versions, by sea and by land. Spain's involvement in the Silk Road initiative must be essential for the turning point that requires the new time of bilateral relations, which is called to overcome the current apathy. Being sidelined will dangerously worsen the peripheral position that Spain already has within China's relations with Europe.
BUSINESS INTELLIGENCE: importância nas empresas para análise na tomada de decisões
Authors: Alencar Isaias Sousa
Published: May 2023

Este estudo teve como o objetivo central de analisar a importância de um conjunto de técnicas e conceitos sobre o Business Intelligence dentro das organizações, afim de fornecer parâmetros na análise das tomadas de decisões empresariais. As empresas para se manterem competitivas no mercado se faz necessário a utilização de preceitos e tecnologia e o preceito sobre Business Intelligence tende a fornecer respaldo para as organizações, neste sentido. Dentre os autores pesquisados para a constituição conceitual deste trabalho, destacaram-se Phan, Vogel (2010), Gartner Group (2011), Mikroyannidis; Theodoulidis, (2010), Popovic e Jaklic (2010) e Affeldt; Junior, (2013). A metodologia utilizada foi a pesquisa qualitativa com viés descritivo, tendo como coleta de dados o levantamento bibliográfico.
A comprehensive review on phytochemistry, nutritional and pharmacological properties of Momordica charantia
Authors: Singh Pankaj , Pandey Pragati , Singh Pradeep Kumar , Tripathi Manikant , Singh Rajat Pratap , Shukla Shikha , Pathak Neelam , Singh Ram Lakhan
Published: May 2023

is known as the bitter gourd or bitter melon and is a member of the family Cucurbitaceae. It is a medicinal plant and its fruit is consumed as a food also. This plant is grown in tropical as well as subtropical areas around the world, mainly in Asia, India, China, South America and Brazil. Due to the presence of bioactive compounds like charantin, α-momorcharin and cucurbitacins, some of which possess potent biological actions, this plant is used in folk medicine all over the world and has many pharmacological activities, like antidiabetic, anticancerous, antimicrobial, antioxidant, antiviral, antimalarial, antihelmintic etc. This plant has been used as traditional medicine in various diseases treatments like syphilis, rheumatism, gout, and illness of the liver and spleen. But mainly is famous for its effectiveness in the treatment of diabetes due to the presence of polypeptide-p and is also known as p-insulin due to very similarity in function against diabetes.
A comprehensive review on applications, preparation & characterization of nanoemulsion
Authors: Prajapati Bhupendra G. , Parihar Akshay , Macwan Mercy , Pal Swati
Published: May 2023

With time, dosage forms have progressed, from essential tablets to advanced systems, which are now more focused on providing better ease of administration to the patients. One such advantageous novel drug delivery system is Nanoemulsion based drug delivery. The Nanoemulsion-based system is reasonably a new means of enhancing drug delivery; Nanoemulsions are sub-micron size particles roughly in the size range of 50-600 nm. The review focuses on conveying information by combining various articles and study reports to understand the work done in this field. This review paper aims to serve as a tool to understand the development of Nanoemulsion. The study comprehensively analyses the preparation methods, composition, characterization, and stability and their application in drug delivery via various routes. Lastly, the paper also describes the recent five formulations prepared for nanoemulsions and their applicability as discussed in the literature.
El recreo de la infancia: Argumentos para otro comienzo
Authors: Bustelo Eduardo
Published: May 2023

El recreo de la infancia constituye, en realidad, un lúcido y muy poco frecuente intento de desentrañar críticamente (en el profundo sentido del sociólogo estadounidense Charles Wright Mills) algunas razones del malestar social contemporáneo. En él me parece vislumbrar también un cálido homenaje a un verdadero maestro en esta línea poco frecuente de pensamiento y reflexión. No creo equivocarme al identificar El recreo de la infancia como un magnífico tributo a lo mejor del pensamiento filosófico de Alessandro Baratta dedicado al tema de la infancia. Un pensamiento cuya amplitud trasciende la cuestión de la niñez. Sin embargo, no es este un libro sobre, ni mucho menos para la infancia. Es, en todo caso, un libro con la infancia. Porque no es en la infancia donde Eduardo Bustelo identifica las posibilidades emancipatorias de un nuevo comienzo, sino en un diálogo inédito entre adultos y niños. Para ello, se ofrecen aquí algunas coordenadas que no deberían desaprovecharse. La recuperación para este análisis del riquísimo y relegado concepto de la Grecia clásica, redescubierto por Foucault, de parrhesía —entendido como un diálogo franco y sincero— sostiene un delicado equilibrio en el que poesía y rigor se articulan con una sobriedad no desprovista de eficacia. Sin ser en modo alguno un texto fácil, este trabajo resulta tan convocante como envolvente. No hay aquí una demagógica idea metafísica de la infancia como paraíso perdido, ni tampoco como artilugio mágico de una tierra prometida. Es que, en definitiva, no es este un libro sobre la infancia sino sobre la libertad. Emilio García Méndez, Fragmentos del Prólogo
Circular RNA-AnnexinA7 accelerates cisplatin resistance in non-small cell lung cancer via modulating microRNA-545-3p to mediate Cyclin D1
Authors: Yao Jian , Zhang Hai Yang , Gu Shuang , Zou Jin Long , Zhang Qiang , Qu Ri Chu
Published: May 2023

Objective: To explore the mechanism of circular RNA (circRNA)-AnnexinA7 (ANXA7) in non-small cell lung cancer (NSCLC) cisplatin (DDP) resistance through microRNA (miR)-545-3p to target Cyclin D1 (CCND1). Methods: DDP-resistant and non-resistant NSCLC tissues and normal tissues were collected. DDP-resistant cells (A549/DDP and H460/DDP) were constructed. circ-ANXA7, miR-545-3p, CCND1, P-Glycoprotein, and glutathione S-transferase-π in tissues and cells were measured. Analysis of circ-ANXA7 ring structure was performed, as well as detection of circ-ANXA7 distribution in cells. Cell proliferation was detected by MTT and colony formation assay, apoptosis rate was detected by flow cytometry, and cell migration and invasion were evaluated by Transwell assay. The targeting relationship between circ-ANXA7, miR-545-3p and CCND1 was verified. Measurement of tumor volume and quality in mice was performed. Results: Circ-ANXA7 and CCND1 were elevated, while miR-545-3p was suppressed in DDP-resistant NSCLC tissues and cells. Circ-ANXA7 combined with miR-545-3p, which targeted CCND1 to expedite A549/DDP cell proliferation, migration, invasion, DDP resistance, but inhibited cell apoptosis. Conclusion: Circ-ANXA7 enhances DDP resistance in NSCLC via absorbing miR-545-3p to target CCND1 and might be a latent therapeutic target for NSCLC.
Principais adversidades geradas pela pandemia na fabricação e venda de móveis rústicos, na percepção de um empreendedor de uma pequena indústria moveleira
Authors: Estéban Stephanie Duarte , Acorinte Thais Rodrigues de Almeida
Published: May 2023

Com a pandemia do Covid 19, muitas foram as dificuldades enfrentadas pelo setor moveleiro. Essa pesquisa foi feita com o intuito de observar quais foram as adversidades enfrentadas na percepção de um empreendedor de uma pequena indústria moveleira. A pesquisa teve como objetivos específicos: (1) identificar as principais dificuldades enfrentadas na percepção do empreendedor; (2) verificar os processos de fabricação e venda que foram alterados pela indústria para continuar realizando suas atividades no contexto da pandemia; (3) mapear quais alterações se fizeram necessárias ao abastecimento de matéria prima, principalmente a madeira e por fim (4) identificar as demais medidas que foram necessárias para manter a sobrevivência da empresa (corte de pessoal, custos em geral e etc). A fim de atingir os objetivos, foi feita uma pesquisa exploratória, de cunho qualitativo, por meio do método de estudo de caso. As técnicas selecionadas para a coleta de dados foram a da entrevista com roteiro semiestruturado e observação não participante. Os dados foram compreendidos por meio da análise de conteúdo. Como resultados da pesquisa, observou-se que, dentre as principais adversidades, pode-se citar a paralisação temporária da produção, o aumento significativo do valor da madeira – principal matéria prima utilizada, aumento dos combustíveis, impactando diretamente o valor do frete e, consequentemente, o custo do produto, que ocasionou a redução das vendas e o aumento da inadimplência.
A PERSPECTIVA BLOCKCHAIN NAS COMPRAS GOVERNAMENTAIS
Authors: De oliveira Joao Alex
Published: May 2023

A tecnologia que serve de base para os criptoativos (ou criptomoedas) é considerada uma das principais tendências para a transformação digital. Disruptiva por essência, a tecnologia blockchain (ou cadeia de blocos) pode contribuir para promover otimização em vários contextos da atuação humana. O presente trabalho tem por finalidade mapear o processo de compras compartilhadas de TIC do Instituto Federal Sul de Minas e apresentar abordagens possíveis para otimização. A partir de concepções baseadas na arquitetura blockchain foram exploradas abordagens possíveis de correção aos problemas de fluxo identificados, observando aspectos de desburocratização e de desintermediação, sem  deixar de assegurar a integridade, a auditabilidade e a rastreabilidade que devem ser inerentes às licitações públicas. Os resultados, embora sejam conclusivos para o escopo do estudo, são intermediários por se tratarem de uma proposta a ser implementada: diagramas obtidos a partir do mapeamento do processo que permitiram abstrair (visualmente) suas etapas; e proposta de abordagem que representa como poderia ser a realização do processo implementado em uma plataforma blockchain.
ENCONTROS E DESENCONTROS INTERDISCPLINARES: a experiência de formação em um programa de pós-graduação
Authors: Carvalho João Francisco Sarno
Published: May 2023

Relato de experiência de trajetória acadêmica de formação em mestrado acadêmico de cunho interdisciplinar, realizado em programa de pós-graduação da Universidade Federal de Itajubá, no período de agosto de 2014 a agosto de 2016. Utilizou-se as seguintes técnicas de coleta de dados: caderno de campo e observação participante. Como objetivo este texto busca apresentar as principais experiências vividas por um acadêmico de um mestrado de linha interdisciplinar. Os resultados mostram que a experiência foi significativa, sinalizando que a pós-graduação em caráter interdisciplinar é desafiadora para docentes e discentes.
Editorial
Authors: Caliari Juliano Souza
Published: May 2023

Resumo artigos
A method for determining the optimal technique of surgical intervention in patients with post-traumatic kyphotic deformity of the thoracolumbar spine in the late period of spinal injury.
Authors: Ptashnikov Dmitriy Alexandrovich , Magomedov Shamil Shamsudinovich , Rominsky Sergey Petrovich , Mytyga Pavel Gennadievich
Published: May 2023

Introduction. Spinal fractures account for 63.6 cases per 100,000 populations. Of these, the largest number falls on the Th10-L2 zone. Regardless of the choice of treatment tactics in the early period of spinal injury, a vast number of patients continue to complain of local pain and deformity. In these patients, surgical treatment may be indicated. At the preoperative stage, the operating surgeon faces the problem of choosing an intervention of sufficient volume.The aim of the study was to determine the optimal amount of corrective surgical interventions in patients with kyphotic deformity that has developed as a result of a vertebral fracture.Methods. Patients with a medical history of vertebral compression fracture and local kyphotic deformity greater than 11 degrees were enrolled in a single-centre, prospective, experimental study. All patients were divided into three groups according to the studied algorithm. Patients in group A underwent two-stage surgical treatment with corporectomy, implantation of a mesh interbody implant, and posterior transpedicular fixation from two approaches. Group B patients underwent one-stage surgical treatment with corporectomy and implantation of a mesh interbody implant from a single approach. Patients of group C underwent corrective vertebrotomy without the use of a mesh implant. The degree of deformity correction, the traumatism of surgical intervention, the stability of the metal structure, the formation of a bone block, and changes in the functional status of the patient were assessed. Patients were followed up for 24 months after surgical treatment.Results. The study was completed by 114 patients. Surgical treatment options used allowed achieving good results in the correction of deformity in all groups, in groups B and C the traumatism of the operation was significantly (p=0.05) lower than in group A. A bone block was formed in all study groups. It is important to note that patients in group B had transient radicular pain in the early postoperative period, which probably associated with the traction of neural structures during the installation of an interbody mesh implant.Conclusion. Application of the presented algorithm allowed us to achieve comparable beneficial results in patients of all study groups, however, a small sample and the absence of control subgroups do not allow us to extrapolate the study results to the entire population.
Surgical Aspects of Treatment of Hilar Cholangiocarcinoma
Authors: Abdullaeva Asli Zurpukalovna , Medzhidov Rasul Tenchaevich , Murtuzalieva Anzirat Sultanmuradovna
Published: May 2023

Introduction. Treatment of hilar cholangiocarcinoma remains one of the most complicated issues of surgical hepatology. As known, hilar cholangiocarcinoma is resistant to chemotherapy and radiation therapy, and only a surgical option is an effective way to improve patient survival.The aim of the study was to improve clinical outcomes of patients with cholangiocarcinoma by evaluating the efficiency of various options for resection and reconstructive and restorative stages of surgical treatment.Methods. The study involved clinical findings and outcomes of 68 patients with hilar cholangiocarcinoma. Biliary decompression was performed in 61 (89.7%) cases. Radical surgical interventions were performed in 35 (51.4%) cases, and palliative surgical interventions were performed in 33 (48.6%) cases.Results. Specific complications at the stage of biliary decompression were noted in 4 (6.5%) cases, inadequate drainage of the biliary tract occurred in 5 (8.2%) cases. The syndrome of "rapid decompression of the biliary tract" was recorded in 14 (23.0%) cases, cholangitis - in 12 (19.7%). Intraoperative complications were noted in 2 (15.3%) cases, postoperative - in 6 (17.1%) cases. Mortality rate was 8.5%. In the long-term period, stenosis of the biliodigistic anastomosis was recorded in 11.4% of cases, tumor recurrence occurred in 28.6% of cases. The five-year survival rate was 17.0%.Conclusion. Resection of the bile ducts combined with hemihepatectomy is an operation accompanied by high risks, especially at the height of jaundice and in the elderly patients. Performing a sparing hiatal resection of the liver and bile ducts provides an acceptable survival rate. The proposed method to form a biliodigistic anastomosis is effective in terms of preventing insolvency and stenosis of the anastomosis.