bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinicopathological significance of the EMT-related proteins and their interrelationships in prostate cancer. An immunohistochemical study
Authors: Parol-Kulczyk Martyna , Gzil Arkadiusz , Maciejewska Joanna , Bodnar Magdalena , Grzanka Dariusz
Published: June 2021

The chronic inflammation influences a microenvironment, where as a result of losing control over tissue homeostatic mechanisms, the carcinogenesis process may be induced. Inflammatory response cells can secrete a number of factors that support both initiation and progression of cancer and also they may consequently induct an epithelial-mesenchymal transition (EMT), the process responsible for development of distant metastasis. Macrophage migration inhibitory factor (MIF) acts as a pro-inflammatory cytokine that is considered as a link between chronic inflammation and tumor development. MIF can function as a modulator of important cancer-related genes expression, as well as an activator of signaling pathways that promotes the development of prostate cancer. The study was performed on FFPE tissues resected from patients who underwent radical prostatectomy. To investigate the relationship of studied proteins with involvement in tumor progression and initiation of epithelial-to-mesenchymal transition (EMT) process, we selected clinicopathological parameters related to tumor progression. Immunohistochemical analyses of MIF, SOX-4, β-catenin and E-cadherin were performed on TMA slides. We found a statistically significant correlation of overall β-catenin expression with the both lymph node metastasis (p<0.001) and presence of angioinvasion (p = 0.012). Membrane β-catenin expression was associated with distant metastasis (p = 0.021). In turn, nuclear MIF was correlated with lymph node metastasis (p = 0.003). The positive protein-protein correlations have been shown between the total β-catenin protein expression level with level of nuclear SOX-4 protein expression (r = 0.27; p<0.05) as well as negative correlation of β-catenin expression with level of nuclear MIF protein expression (r = -0.23; p<0.05). Our results seem promising and strongly highlight the potential role of MIF in development of nodal metastases as well as may confirm an involvement of β-catenin in disease spread in case of prostate cancer.
Progress in survival in renal cell carcinoma through 50 years evaluated in Finland and Sweden
Authors: Hemminki Kari , Försti Asta , Hemminki Akseli , Ljungberg Börje , Hemminki Otto
Published: June 2021

Global survival studies have shown favorable development in renal cell carcinoma (RCC) treatment but few studies have considered extended periods or covered populations for which medical care is essentially free of charge. We analyzed RCC survival in Finland and Sweden over a 50-year period (1967–2016) using data from the NORDCAN database provided by the local cancer registries. While the health care systems are largely similar in the two countries, the economic resources have been stronger in Sweden. In addition to the standard 1- and 5-year relative survival rates, we calculated the difference between these as a measure of how well survival was maintained between years 1 and 5. Relative 1- year survival rates increased almost linearly in both countries and reached 90% in Sweden and 80% in Finland. Although 5-year survival also developed favorably the difference between 1- and 5-year survival rates did not improve in Sweden suggesting that the gains in 5-year survival were entirely due to gains in 1-year survival. In Finland there was a gain in survival between years 1 and 5, but the gain in 1-years survival was the main contributor to the favorable 5-year survival. Age group specific analysis showed large survival differences, particularly among women. Towards the end of the follow-up period the differences narrowed but the disadvantage of the old patients remained in 5-year survival. The limitations of the study were lack of information on performed treatment and clinical stage in the NORDCAN database. In conclusion, the available data suggest that earlier diagnosis and surgical treatment of RCC have been the main driver of the favorable change in survival during the past 50 years. The main challenges are to reduce the age-specific survival gaps, particularly among women, and push survival gains past year 1.
Demonstration of proof-of-concept of StrokeShield system for complete closure and occlusion of the left atrial appendage for non-valvular atrial fibrillation therapy
Authors: Slaughter Mark S. , Monreal Gretel , Koenig Steven C. , Giridharan Guruprasad A. , Tompkins Landon H. , Jimenez Jorge H.
Published: June 2021

In the US, the most significant morbidity and mortality associated with non-valvular atrial fibrillation (NVAF) is embolic stroke, with 90% of thrombus originating from the left atrial appendage (LAA). Anticoagulation is the preferred treatment for the prevention of stroke in NVAF patients, but clinical studies have demonstrated high levels of non-compliance and increased risk of bleeding or ineligibility for anticoagulation therapy, especially in the elderly population where the incidence of NVAF is highest. Alternatively, stroke may be preventing using clinically approved surgical and catheter-based devices to exclude or occlude the LAA, but these devices continue to be plagued by peri-device leaks and thrombus formation because of residual volume. To overcome these limitations, Cor Habere (Louisville, KY) and the University of Louisville are developing a LAA closure device (StrokeShield) that completely occludes and collapses the LAA to minimize the risk of stroke. The StrokeShield device is a collapsible occluder (nitinol reinforced membrane) that completely covers the LAA orifice with an expandable conical coil anchor that attaches to the myocardium. The device is designed for catheter-based delivery and expands to completely occlude the LAA orifice and collapse the LAA. The primary advantages of the StrokeShield system are a completely sealed LAA (no peri-device flow or residual space) and smooth endothelialized connection to the left atrial wall with minimal risk of cardiac bleeding and tamponade. We tested proof-of-concept of a prototype StrokeShield device in acute (n = 2) and chronic 60-day (n = 2) healthy canine models. Acute results demonstrated that the conical coil securely attached to the myocardium (5N pull-out force) and the Nitinol umbrella fully deployed and covered the LAA ostium. Results from the chronic implants demonstrated long-term feasibility of device placement with no procedural or device-related intra- or post-operative complications, secure placement and correct positioning of the device with no device migration. The device successfully occluded the LAA ostium and collapsed the LAA with no interference with the mitral valve, circumflex coronary artery, or pulmonary veins. Necropsy demonstrated no gross signs of thrombus or end-organ damage and the device was encapsulated in the LAA. Histology demonstrated mature neointima covering the device with expected foreign body inflammatory response. These early positive results will help to guide the iterative design process for the continued development of the StrokeShield system.
Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing
Authors: Varghese Elizabeth , Samuel Samson Mathews , Liskova Alena , Kubatka Peter , Büsselberg Dietrich
Published: June 2021

Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a pandemic by WHO on March 11, 2020. Soon after its emergence in late December 2019, it was noticed that diabetic individuals were at an increased risk of COVID-19–associated complications, ICU admissions, and mortality. Maintaining proper blood glucose levels using insulin and/or other oral antidiabetic drugs (such as Metformin) reduced the detrimental effects of COVID-19. Interestingly, in diabetic COVID-19 patients, while insulin administration was associated with adverse outcomes, Metformin treatment was correlated with a significant reduction in disease severity and mortality rates among affected individuals. Metformin was extensively studied for its antioxidant, anti-inflammatory, immunomodulatory, and antiviral capabilities that would explain its ability to confer cardiopulmonary and vascular protection in COVID-19. Here, we describe the various possible molecular mechanisms that contribute to Metformin therapy’s beneficial effects and lay out the scientific basis of repurposing Metformin for use in COVID-19 patients.
A HR szerepe a felelős foglalkoztatóknál
Authors: Boros Brenda , Pókász Zoltán , Süle Ákos , Szabó Dorottya
Published: June 2021

A kutatás célja az, hogy a Magyar Nemzeti Bank 2020. novemberi termelékenységi jelentésére és az “Év Felelős Foglalkoztatója” kiadványra alapozva megvizsgálja négy kérdésből álló kérdőíves módszerrel, hogy a vállalatok hogyan tudtak és tudnak alkalmazkodni a közelmúltban történt változásokhoz a humánerőforrás szemszögéből. Ezekből a változásokból kiemelendő a digitalizáció és az innováció növekvő térnyerése, a koronavírus-járvány és az azzal együtt járó kevesebb személyes kontaktus. Emellett a HR-részlegek potenciális kockázati tényezői is a kutatás tárgyát képezik. Először a Magyar Nemzeti Bank jelentésének releváns részei kerülnek összefoglalásra, ezt az “Év Felelős Foglalkoztatója” kiadvány összefoglalója követi, végül a kérdőív és az arra adott huszonegy válasz bemutatása következik. Az eredményekből látható, hogy a szolgáltatási szektorban és az iparban tevékenykedő vállalatok attitűdje szignifikánsan eltér. Az azonban általánosan kijelenthető, hogy a munkáltatók kifejezetten nagy figyelmet fordítanak a munkavállalók jóllétére, és igyekeznek a pandémia alatt is megőrizni őket. Egy pozitív tendencia látható tehát, melyet azonban szélesebb, az országot érintő makrofolyamatok sokszor hátráltatnak. = The aim of this research is to examine - with a survey of four questions - how corporations could and can adapt to the recent changes from a human resources point of view based on the Hungarian Central Bank’s productivity report of November 2020 and the publication called “Év Felelős Foglalkoztatója'' (Responsible Employer of The Year). The incremental expansion of digitalization and innovation, the coronavirus pandemic as well as the less in-person contact that is inherent with it have to be highlighted out of these changes. Additionally, the potential risk elements of HR departments are also subjects of this research. First, the relevant parts of the Nemzeti Bank’s report are summarized which is followed by the summary of the “Év Felelős Foglalkoztatója” publication, and finally the questionnaire as well as its twenty-one responses are presented. According to the results the attitudes of the corporations operating in the service sector and in the industry significantly differ from each other. Nevertheless, what can be generally determined is that these employers pay special attention to their employees’ well-being and they intend to preserve their employees during the pandemic. Subsequently, a positive tendency can be seen, which is often set back by the wider macro processes of the country.
Közoktatás Szingapúrban = Public education in Singapore
Authors: Csáki György
Published: June 2021

Az 1965-ben függetlenné vált Szingapúrban azonnal bevezették a 6 osztályos kötelező elemi iskolai oktatást – angol nyelven, ami akkor elsősorban az egységes szingapúri identitás megteremtésének eszköze volt. Az angol fokozatosan a teljes oktatási rendszer nyelvévé vált, s a közoktatás folyamatos bővítése mellett a fő hangsúlyt a matematika és a természettudományok oktatására helyezték. Szingapúr városállam, ahol a függetlenség elnyerése óta folyamatosan politikai egypárt-rendszer működik. Ebből adódóan az oktatási rendszer – a tanárképzéstől és -továbbképzéstől a tantervekig és az egyes tananyagokig – erősen centralizált. Mivel az oktatás tervezése a kezdetektől a makrogazdasági tervezés szerves része, a szingapúri oktatási rendszer rugalmasan illeszkedik a gazdasági stratégia változásaihoz. A szingapúri oktatási rendszer alapvetően angolszász típusú, s az ország gazdaságpolitikájának megfelelően folyamatosan igazodik a globális gazdasági és oktatási trendekhez. A szingapúri közoktatás nemzetközi összehasonlításban is különösen sikeres – ezt a továbbtanulási arányok és a PISA-felmérésekben elért kiemelkedő eredményei is tükrözik. = After its independence in 1965, Singapore immediately introduced six years long compulsory and free primary education in English. Teaching in English aimed creating a unified Singaporean identity. English gradually became the working language of the entire education system. Alongside a steady expansion of public education, the main emphasis was placed on mathematics and science. Singapore is a city-state, featuring a one-party political system since its independence. Consequently, its education system, including teacher training and in-service training to curricula and individual teaching materials, is highly centralised. Since education planning has been an integral part of macroeconomic planning, the education system in Singapore has been flexibly aligned to changes in economic strategy. Singapore's education system is essentially Anglo-Saxon and has been constantly adapted to global economic and educational trends just like the country's economic policy. Singapore's public education system is particularly successful by international standards, as reflected by the high share of students continuing studies in higher-level educational institutions as well as by Singapore’s outstanding rankings in the PISA surveys.
A felhalmozott nyugdíjjárulékok előtörlesztési célú felhasználásának modellezése lakáscélú hitelek esetén = Modelling the use of accumulated pension contributions for repayment of housing loans
Authors: Mérő Bence
Published: June 2021

A befizetett nyugdíjjárulékok a járulékfizetők szempontjából részben megtakarításként értelmezhetők. Mivel lakáshitel felvételekor a járulékfizető hitelfelvevők nem férnek hozzá ezekhez a megtakarításokhoz, magasabb hitelösszeget kell felvenniük, ami után jellemzően magasabb kamatot kell fizetniük, mint amennyi a nem hozzáférhető megtakarításaik hozama. Ha az egyén szerződhetne az állammal arra, hogy a nyugdíjjárulékai egy részét előtörlesztésként felhasználhassa, és az államnál így keletkező hiányt kamatostul visszafizeti, akkor a hitelfelvevő életpályajövedelme növekedne, mivel a lakáshitelek kamata magasabb az államkötvények kamatánál. Ha az így keletkezett jövedelmet az egyén a nyugdíjkasszába fizeti, akkor hosszútávon a többletet fel lehet osztani az állam és az egyén későbbi nyugdíjkifizetése között. Bizonyos esetekben a hitelszerződés lejáratakor az egyén felhalmozott nyugdíjjárulékai akár 25-30 százalékkal is magasabbak lehetnek. A 2017-ben fennálló lakáscélú hitelek állománya esetében az alkalmazott módszer 20 éves időtávon reálértéken kb. 500 Mrd forinttal magasabb felhalmozott járulékfizetést eredményezhet. Ha 2018-tól kezdve minden újonnan megkötött lakáscélú hitel esetében biztosítjuk a szóban forgó lehetőséget, és ezért később magasabb nyugdíjakat is kapnak a programban részt vevők, az növelné az államadósságot, az elérhető nyugdíjtöbblet azonban nagyobb az állam által viselt terheknél. = Pension contributions may partly be considered as savings from the contributors’ perspective. Since borrowers cannot access this kind of savings when taking a mortgage loan, they need to borrow a higher loan amount, the interest of which is usually higher than the implied return on pension contributions. If contributors could contract the state to use their contributions for early repayment and pay the increased deficit of the state with interest, the life cycle income of the contributor could increase since the interest rate of mortgage loans is higher than government bond yields. If the difference is transferred to the state pension fund, in the long run it could be shared between the state and the contributor. In this way in some cases the accumulated pension contributions may be 25 to 30 percent higher at the expiration of the original loan contract. Considering the prevailing housing loans in 2017 in Hungary, the applied method could increase pension contributions by around 500 billion HUF at constant prices in twenty years. If from 2018 on, contributors could use their public pension savings regarding all new housing loan contracts, this would increase government debt, but the higher pensions in the future would be greater than the additional burden of the government.
The V4’s Gas Market transition towards the EU’s Energy Security
Authors: Sárvári Katarína
Published: June 2021

Current development of the European gas market uncovers several new opportunities and challenges for energy security that developed from big changes in production, transit and supply ways of natural gas to Europe. New European gas market model builds on the principles of diversification, the security of supply, interconnectivity and liberalization. Realization of the EU Third Energy Package related to a progressive shift from long-term oil-linked gas supply contracts and development of alternative gas supply sources and lines, as well as the rivalry between already established gas transit lines and the new supply lines present new challenges and require transition for the V4 countries. In this article I studied what are the new changes and challenges of the transition of V4 countries towards the EU’s energy security? To adjust to transition V4 countries should build the new infrastructure on the short-term pricing market and the ways how it will be funded. If V4 countries want to trade gas with the neighbours and transport most of the Russian gas to Europe, they need to invest into reforms of pipelines’ networks or to find other alternatives of diversification in the next decades. Returns on investment on a liberalized market with a multitude of competitors will be manageable but require serious reforms. The V4 countries will have to enter into the spot markets to efficiently trade gas. Available gas hubs in Europe are much smaller, less liquid, and mostly supplied by the same companies as the long-term traded gas hubs. This kind of markets is easy to manipulate. Therefore, it is important for the V4 countries to plan how to coordinate their national energy policies and name EU’s energy targets for the future.
Políticas de biocombustíveis no Brasil
Authors: Barcelos Márcio
Published: June 2021

Este texto analisa o processo de construção da agenda da primeira política pública de larga escala na área de biocombustíveis no Brasil, o Programa Nacional do Álcool (PROALCOOL). É dada ênfase ao papel das ideias e á agência dos atores envolvidos. O objetivo foi rastrear o desenvolvimento de um conjunto de ideias e percepções que estabeleceram uma policy image na área de biocombustíveis, e estabeleceram os alicerces do que seria a experiência brasileira em políticas públicas para combustíveis renováveis. Utilizou-se a abordagem do rastreamento de processos (process tracing), com base em pesquisa documental, para examinar os fatores relacionados ao papel das ideias e como os agentes as mobilizaram no sentido de estabelecer o etanol como uma questão de política pública (public policy issue).
Real fantástico? O deslumbramento científico em Walmor Corrêa
Authors: Scholze Sara de Oliveira Lima , Furtado Matheus Silveira
Published: June 2021

Os limites entre o imaginário da arte e o imaginário da ciência na poética de Walmor Corrêa são praticamente inexistentes. Mais do que uma preferência de ordem temática, essas confluências de seus trabalhos são uma preocupação essencial. Quando o artista se apropria de linguagens e técnicas associadas aos âmbitos da biologia e ilustração científica e reconfigura as formas e características a partir de uma criatura fantástica e exótica, ele proporciona um deslumbramento encantador para o observador, ele cria não apenas um ser, mas também um cenário, uma narrativa, uma forma de catalogá-lo, entendê-lo e apresentá-lo aos curiosos. Por meio de seu trabalho sobrevivem aspectos culturais e teóricos que cercam ambas as disciplinas, e moldam a compreensão sobre o papel da influência que o imaginário do passado consolida no presente.
David Lynch
Authors: Rouquet Karine
Published: June 2021

Ce petit film, au-delà de l’héritage revendiqué du surréalisme, utilise des procédés comiques et fantastiques hybrides (création d’une chimère, narration disruptive, dialogues abusant du coq-à-l’âne et tournant à la fatrasie) qui relèvent de l’inversion carnavalesque décrite par Michaël Bakhtine et plus particulièrement de la Sottie, pièce satyrique en vers que l’on représentait au moment du carnaval. La référence aux Absurda de Érasme en serait la preuve. Dans cette parade bouffonne, David Lynch en Maître-Sot ou Maître es Folie s’amuse à court-circuiter les codes du film noir de la narration, comme de as propre filmographie, créant une esthétique turbulente propre à défier la plateforme disruptive sur laquelle il fait son entrée.
La comunidad cristiana, en el corazón de la escuela católica
Authors: Alonso Arroyo Francisco Javier
Published: June 2021

Las escuelas católicas tienen el gran desafío de fortalecer su identidad carismática en un nuevo escenario social y eclesial marcado por la indiferencia religiosa y el descenso de vocaciones religiosas educativas. Para salvar su identidad, se debería poner como objetivo prioritario del proyecto pastoral de la escuela, la creación de una comunidad cristiana viva que sea un signo visible para la comunidad educativa (alumnos, padres, personal, exalumnos), fuente de inspiración de todos los procesos pastorales y lugar de celebración de la vida cristiana.
Karola B. Janowskiego przygoda z kulturą polityczną
Authors: Żmigrodzki Marek
Published: June 2021

Głos w dyskusji
The Skill Hypothesis: A Variant
Authors: Sterelny Kim
Published: June 2021

The basic idea of Birch’s analysis is plausible: normative guidance began in agents’ assessment of their own craft skills. But I suggest developing that idea in a different way. I suggest that proto-normative affect plays its guiding role diachronically, in the development of those skills, rather than synchronically, in modulating their moment-by-moment execution. More importantly, I suggest a different pathway to normative affect’s direction at second and third parties. Normative response became social in the context of skilled collaborative activities, for in those activities others’ failures have material consequences for each agent. In such collaborations, all have reason to care about others’ skill, or lack of it.
Polymorphism of nucleolar organizer regions in different Ukrainian cattle breeds
Authors: Dzitsiuk V. , Typylo H. , Mitiohlo I.
Published: June 2021

Aim. To study the activity of nucleolar organizer regions (NORs) in different Ukrainian cattle breeds in terms of their
apparent activity status in silver stain and possible relation with milk productivity. Methods. Chromosome prepara-
tions using lymphocytes from the peripheral blood of 90 cows of different breeds were used in the study. NOR activity
was determined by visual evaluation of concentrations of silver precipitation on NORs in individual chromosomes.
A 50 % silver nitrate solution was used to stain chromosome preparations. NORs were detected as dark spots on
telomeres of the corresponding chromosomes. Results. The cytological analysis of chromosome preparations from
lymphocytes of first lactation cows detected NOR polymorphism in Ukrainian Red-and-Motley dairy cattle (URM),
Ukrainian Black-and-White dairy breed (UBW), and hybrid cows, obtained by crossing Ukrainian Red-and-Motley
dairy breed and Montbeliarde bulls (URM × M). First lactation cows of URM and UBM had higher or the same inci-
dence of cells with four (29.8 and 30 %) and five (17.1 and 19.5 %) NORs, while in URM × M cows the incidence of
cells with the same number of NORs was almost twice lower; cells with 7 and 8 NORs exceeded a similar index for
other investigated breeds almost twice (2.5 against 4.5 % and 2.0 against 4.2 %). The highest level of chromosomal
aberrations (CA) was observed in the group of animals with medium number (2 to 3 NORs per cell), and the lowest –
in the group with a high number of NORs (from 6 to 7) with a reliable intergroup difference (p < 0.01). NOR activity
was the highest in the group of animals of local origin (URM × M) with a milk yield over 7,000 kg in 305 days of the
first lactation and the lowest in the UBW cows with a milk yield of 4–5,000 kg during the first lactation. Conclusions.
We determined the differences in the activity of nucleolar organizers between the investigated groups of cows of dairy
breed. URM × M hybrids reliably (р ≤ 0.05) exceeded dairy UBW cows by this index. No statistically significant different was found between other investigated groups of animals by this trait. Higher dairy productivity was found in the
animals with higher frequency of NORs in the chromosomes of metaphase cells. In our opinion, the number of active
NORs demonstrates relative variability between their number and the rate of protein synthesis, required to implement
the productivity traits of the investigated animals.
Immune response of the harderian gland in chickens to infectious bronchitis coronavirus
Authors: Guralska S. , Kot T. , Dyshliuk N. , Zaika S. , Khomenko Z.
Published: June 2021

Aim. To determine the difference in immune responses of the harderian gland in clinically healthy chickens and the
ones with infectious bronchitis based on the content, localization and morphometric estimation of the surface markers
of Т- and В-lymphocytes and to determine the differentiation index as an indicator of assessing body defenses.
Methods. Histological, immunohistochemical, optical, morphometric and statistical. Results. The histological study
of the harderian gland of chickens with infectious bronchitis determined the swelling and proliferation of the connective
tissue as well as infiltration of secretory lobules by lymphoid cells. It was found that the immunity of chickens with
infectious bronchitis, in which the harderian gland plays a relevant role, depends considerably on the differentiation
index of immunocompetent cells. There was a reliable 1.77- and 1.36-fold decrease in this indicator for 40- and
90-day-old chickens, respectively, in case of nephroso-nephritic form of infectious bronchitis which demonstrated a
weaker function of the defense cells of this organ. According to the cytomorphometric analysis, the number of cells,
expressing CD4+, CD8+, CD20+, CD45RA+ markers in the harderian gland of sick 20-, 40-, and 90-day-old chickens
with respiratory and nephroso-nephritic forms of infectious bronchitis was reliably (P < 0.05) increasing compared
to the clinically healthy chickens. For instance, the number of mature В-lymphocytes increased in sick 20-day-old
chickens – 2.44 times, 40-day-old chickens – 1.88 times, and 90-day-old ones – 2.62 times compared to clinically
healthy chickens. Conclusions. The data were obtained about the changes in quantitative and qualitative composition
of lymphocytes with surface markers CD4+, CD8+, CD20+, CD45RA+ in the harderian gland of chickens with infectious
bronchitis. Our results will supplement current knowledge about the feasibility of immunohistochemical methods in
the diagnostics of avian infectious bronchitis.
2020 Asian Pacific Society of Cardiology Consensus Recommendations on Antithrombotic Management for High-risk Chronic Coronary Syndrome
Authors: Tan Jack Wei Chieh , Chew Derek P , Brieger David , Eikelboom John , Montalescot Gilles , Ako Junya , Kim Byeong-Keuk , Quek David KL , Aitken Sarah J , Chow Clara K , Chour Sok , Tse Hung Fat , Kaul Upendra , Firdaus Isman , Kubo Takashi , Liew Boon Wah , Chong Tze Tec , Sin Kenny YK , Yeh Hung-I , Buddhari Wacin , Chunhamaneewat Narathip , Hasan Faisal , Fox Keith AA , Nguyen Quang Ngoc , Lo Sidney TH
Published: June 2021

The unique characteristics of patients with chronic coronary syndrome (CCS) in the Asia-Pacific region, heterogeneous approaches because of differences in accesses and resources and low number of patients from the Asia-Pacific region in pivotal studies, mean that international guidelines cannot be routinely applied to these populations. The Asian Pacific Society of Cardiology developed these consensus recommendations to summarise current evidence on the management of CCS and provide recommendations to assist clinicians treat patients from the region. The consensus recommendations were developed by an expert consensus panel who reviewed and appraised the available literature, with focus on data from patients in Asia-Pacific. Consensus statements were developed then put to an online vote. The resulting recommendations provide guidance on the assessment and management of bleeding and ischaemic risks in Asian CCS patients. Furthermore, the selection of long-term antithrombotic therapy is discussed, including the role of single antiplatelet therapy, dual antiplatelet therapy and dual pathway inhibition therapy.
Your Name (Kimi no na wa, Shinkai Makoto, 2016). Multiversos y hologramas (in)finitos
Authors: Torres Hortelano Lorenzo
Published: June 2021

En este artículo se relacionan algunos de los temas que suelen movilizarse en el mejor anime contemporáneo —como los multiversos y los décadrage temporales— con una teoría del cine relacionada, a su vez, con los hologramas y el inconsciente del espectador. Para ello, se analizan algunas secuencias claves de una película ejemplar en este sentido: Your Name (Kimi no na wa) de Shinkai Makoto (2016).
Caricatura, crítica y pensamiento visual de la realidad desde la provincia colombiana
Authors: Coral Bustos Willan Fernando
Published: June 2021

El texto expone la relación entre la investigación del diseño como proceso sistemático con la caracterización de la caricatura política como género de opinión en San Juan de Pasto, valiéndose de elementos discursivos y visuales considerados arma de lucha que desde su origen ha fortalecido la denuncia social. Así, esta investigación se desarrolló desde el enfoque cualitativo, ya que se determinaron tres categorías de la caricatura política en Pasto: personajes, situaciones y sociedad. De igual manera la investigación estableció una serie de relaciones e interpretaciones a través de la hermenéutica. Teniendo en cuenta la acción humana que tiene sentido para este caso específico desde la acción política. De este modo así, se estableció la relación entre la caricatura con los hechos políticos, con el periodismo y naturalmente con el diseño visual. Desde esta última relación se articuló un método desde el análisis semiótico discursivo de los contenidos de la caricatura que da cuenta de la acción performativa ya que sobresalen prácticas del orden social, histórico cultural y político que se expresa a través de la ironía.
El cine como tecnología expresiva para la paz. Entrevistas, esbozos de ideas y posibles aplicaciones
Authors: Moreno Salazar Felipe
Published: June 2021

Este texto aborda y transcribe largos fragmentos de tres entrevistas1 con investigadores y creadores audiovisuales sobre sus ideas acerca del cine como tecnología para la paz y esboza algunas aplicaciones de esta aproximación creativa en el contexto. Según lo extraído de los testimonios, en el lenguaje artístico del cine podemos identificar tendencias estéticas y algunas funciones pragmáticas que lo harían una tecnología expresiva para la paz. También podemos identificar obras audiovisuales que, al no considerar variables estéticas y funciones pragmáticas, se apartan de esta búsqueda y podríamos considerar tecnologías para la guerra. Finalmente, la construcción de relatos con una profunda búsqueda de los verdadero, una adecuada investigación creación sobre el contexto desde el cual surge la obra y una consideración del público a quien va dirigida serían algunas de las características que deben cumplir las películas que se acercan al cine como tecnología para la paz.

Nota: Además de las entrevistas, este texto da cuenta del trabajo en la creación de un marco teórico para el proyecto: Videoesferas del Caribe colombiano: preservación, memoria, análisis y apropiación social del archivo de producción propia del Programa de Cine y Audiovisuales de la Universidad del Magdalena2.
Imagen como evidencia: visualidad de niños y niñas menores de seis años en la localidad de Suba
Authors: Olarte Triana Javier Segundo
Published: June 2021

Este trabajo indaga sobre las narrativas visuales que niños y niñas de primera infancia, de la localidad de Suba, crean y recrean, teniendo como motor de su creatividad, la experiencia vivida. Visualidad que se construye a través del dibujo. Las narrativas visuales entendidas como poética de la mirada, construcción de relatos por la vía de las imágenes, lógica imposible del pensamiento visual. El artículo centra la mirada en la primera infancia, porque se le asocia con la idea de mudez, de silencio, de no poder hablar, desconociendo de este modo el rol definitivo de los niños y las niñas como constructores de conocimiento, como productores de cultura. En consecuencia, surgen las siguientes preguntas: ¿cómo operan esas lógicas narrativas en los niños y niñas de la localidad de Suba? ¿A qué estructuras obedecen? Una hipótesis radica en que la visualidad y el relato, permiten a niños y niñas automirarse a través de la imagen, establecer relaciones con sus pares, edificar discursos tan ricos y prolíficos como el discurso de las palabras. Por lo tanto, es una investigación basada en imágenes, que busca establecer relaciones entre los dibujos de los niños, el pensamiento visual y la particularidad. El resultado de todo el laboratorio visual, es la consolidación de la imagen infantil como huella y evidencia del pensamiento particular; el túnel que permite tránsito entre lo simbólico y la realidad.
La violencia, incómoda compañera de viaje de nuestra historia
Authors: Goyes Narváez Julio César
Published: June 2021

Entrevista al profesor de la Universidad Nacional de Colombia Alejo Vargas Velásquez, director del Centro de Pensamiento y Seguimiento al Diálogo de Paz, por Julio César Goyes Narváez, coeditor en jefe de Actio y profesor del Instituto de Estudios en Comunicación y Cultura (IECO), acerca del origen y las relaciones entre violencia y política en Colombia, precaria cultura tecnológica, las consecuencias del conflicto armado y la construcción de una paz estable y duradera después de los acuerdos de paz del 2016, entre el Estado Colombiano y las FARC-EP (Entrevista: 13/02/2019).
Investigación del metal y Arqueología Medieval en la península ibérica: estado de la cuestión y nuevas perspectivas
Authors: Hernández Casas Yaiza
Published: June 2021

En este trabajo presentamos una revisión y un balance sobre el estado actual de la investigación metalúrgica en la Arqueología Medieval peninsular. De igual manera, hacemos una reflexión acerca de las nuevas aportaciones que, desde la Arqueometalurgia o la Arqueología de la Producción, aún poco desarrolladas en el ámbito de la Edad Media, pueden contribuir a generar nuevos datos históricos sobre las sociedades medievales a través del conocimiento de la cadena operativa del metal, desde sus centros de explotación, espacios de producción y tecnología hasta su comercialización, vida útil y contexto deposicional.
Kesignifikan Sistematik Ciri Anatomi Pina dan Stip Angiopteris angustifolia C. Presl dan A. Evecta (G. Forst.) Hoffm. [Marattiaceae] di Semenanjung Malaysia
Authors: Talip Noraini , Ayob Siti Nor Azah , Kader Maideen Haja Maideen , Bunawan Hamidun , Abdul Rahman Mohamad Ruzi
Published: June 2021

Kajian perbandingan ciri anatomi dan ciri mikromorfologi pina dan stip Angiopteris angustifolia C. Presl dan A. evecta (G. Forst.) Hoffm. [Marattiaceae] di Semenanjung Malaysia telah dijalankan. Sampel kajian diperoleh dari Bangi, Selangor, Bukit Fraser dan Tanah Tinggi Cameron, Pahang. Objektif kajian adalah untuk mengenal pasti dan menyenaraikan ciri anatomi dan mikromorfologi pina yang boleh digunakan untuk pengecaman dan pembezaan dua spesies Angiopteris. Ciri yang ditemui boleh digunakan untuk membina kekunci pengecaman bagi kedua-dua spesies yang dikaji. Anatomi pina dan stip diperhatikan melalui kaedah hirisan dengan mikrotom gelongsor, siatan epidermis dan penjernihan serta cerapan di bawah mikroskop cahaya menggunakan perisian Cell B. Kajian mikromorfologi pula melibatkan teknik saduran emas, titik pengeringan kritikal dan cerapan di bawah mikroskop imbasan elektron menggunakan perisian SmartSEM. Ciri sepunya bagi kedua-dua spesies adalah kehadiran stel ringkas bentuk arka pada stip dan tulang pina, kehadiran sel musilaj yang agak padat pada sel parenkima korteks, peruratan tengah pina dikotom, peruratan tepi pina terbuka dan tidak bercabang dan kehadiran trikom berlengan pada tulang pina. Ciri diagnosis yang ditemui ialah peruratan palsu pada pina A. angustifolia, bentuk luaran permukaan abaksial stip A. angustifolia berbentuk bulatan lebar manakala A. evecta berbentuk ¾ bulatan. Hiasan kutikel pada epidermis abaksial pina A. angustifolia dengan dinding periklin tenggelam dan dinding antiklin timbul sebaliknya pada A. evecta dinding periklin timbul dan dinding antiklin tenggelam. Kesimpulannya, ciri anatomi dan mikromorfologi pina dan stip mempunyai nilai taksonomi yang boleh digunakan bagi pengecaman dan pembezaan kedua-dua spesies Angiopteris yang dikaji.
Vortex Assisted Liquid-Liquid Microextraction with Back Extraction of Repaglinide, Glibenclamide and Glimepiride in Water Samples
Authors: Owaid Luhaib Sohaib Jumaah , Yahaya Noorfatimah , Alshishani Anas , Jajuli Maizatul Najwa , Miskam Mazidatulakmam
Published: June 2021

A new analytical method based on vortex-assisted liquid-liquid microextraction with back extraction (VALLME-BE) coupled with high performance liquid chromatography was developed for the simultaneous determination of antidiabetic drugs; repaglinide, glibenclamide, and glimepiride in water samples. Chromatographic separation was achieved using C18 column (250 × 4.6 mm × 5 µm) and methanol-phosphate buffer (pH3.7) in the ratio of 70:30 v/v as a mobile phase at a flow rate of 1 mLmin-1. VALLME-BE was performed using 200 μL of n-octane dispersed into the aqueous sample (10 mL) with the aid of vortexing agitation. Then, the analytes were back-extracted from the organic solvent to 0.05 M NaOH (40 µL). Under these conditions, enrichment factor of 155-fold was achieved. The developed VALLME-BE method showed excellent linearity in the range of 30 to 1000 µgL-1 with limit of detection (LOD) of 0.41-1.66 µgL-1 and limit of quantification (LOQ) of 1.38-5.54. 41-1.66 µgL-1. VALLME-BE was applied for the determination of repaglinide, glibenclamide and glimepiride in water samples with the recoveries ranged from 83-109%. The relative standard deviation for inter-day and intra-day precision was less than 9.9%.
Effect of Sugar-Pectin-Citric Acid Pre-Commercialization Formulation on the Physicochemical, Sensory, and Shelf-Life Properties of Musa cavendish Banana Jam
Authors: Wan-Mohtar Wan Abd Al Qadr Imad , Abdul Halim-Lim Sarina , Pillai Balamurugan Joshini , Mohd Saad Mohd Zahiruddin , Azizan Nur Asyiqin Zahia , Jamaludin Adi Ainurzaman , Ilham Zul
Published: June 2021

Cavendish banana is the second most cultivated species in Malaysia due to its high potassium and vitamin B6 content. However, there has been little commercialisation of Cavendish banana in jam making to date because of its unappealing physical characteristics and unsavoury taste. In the present study, response surface methodology was used to determine the optimum quantity of sugar (175-275 g)-pectin (3-7 g)-citric acid (150-234 mL) (SPC) on water activity, °Brix, colour analysis, pH, total titratable acidity (TTA), and sensory attributes of formulated banana jams. The amount of sugar-pectin-citric acid was found to have an effect on the TTA and pH of the banana jams. Conversely, water activity and °Brix were only affected by the amount of sugar. The lightness, L* of the banana jams was influenced by the quantity of pectin and the volume of citric acid added. Sensory analysis using 30 panellists showed that there were changes in the colour, taste, aroma, texture, and overall acceptability of banana jam depending on the amount of sugar used. In a shelf life study, banana jams stored at 4 °C were found to have a longer shelf life compared to those stored at 25 °C. Overall, the optimal formulation for a high-quality banana jam was 281.79 g of sugar, 4.13 g of pectin, and 264.66 mL of citric acid. This study constitutes the first report on the potential pre-commercialisation formulation for Cavendish banana jam production.
Survival Analysis and Prognostic Factors for Prostate Cancer Patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur
Authors: Shah Shamsul Azhar , Ismail Norzaher , Taib Syafiq , Mat Siti Nor , Safian Nazarudin
Published: June 2021

Prostate cancer is the third commonest type of cancer in Malaysian men with the incidence of 1,807 in 2018 compared to 1,186 cases reported in 2014. Prostate cancer is also known to cause disease, economic burden and lead to significant financial implications for the healthcare system. This study aimed to measure the rate of survival and to determine the prognostic factors for prostate cancer patients at Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur. This was a retrospective study design involving prostate cancer patients who had been diagnosed and had sought treatment at Universiti Kebangsaan Malaysia Medical Centre from 2008 to 2017. Data were obtained from the patients’ medical records based on TRUS biopsy. The study period was from July 2017 to December 2018. Survival probabilities were estimated using Kaplan-Meier, and differences were compared using the log-rank test. The adjusted hazard ratio (HR) for variables was estimated after fitting the Cox proportion hazard model. Patients' death status due to prostate cancer was the endpoint of the survival analysis. A total of 283 patients’ data were analysed. Total five-year and ten-year survival rates of prostate cancer patients were 77.8 and 65.5%, respectively, regardless of the stage and treatment. The predictor factors for survival age were ≥75 years (HR = 8.49, 95% C.I: 1.16-62.13), Gleason score ≥8 (HR = 2.36, 95% C.I: 1.18-4.73) and cancer metastasis complications (HR = 5.26, 95% C.I: 2.88-9.63). Survival rates and prognostic factors of prostate cancer in the study were almost similar to those in nearby countries in the region. Preventive actions such as prostate cancer screening, early detection of cancer and early treatment should be empowered to improve the survival rate of prostate cancer patients in this hospital.
Realistic dosage of tummy time practice during infancy.
Authors: Lee Do , Barros Joao , Hauck Janet
Published: June 2021

Background: The pediatricians recommend “tummy time” (placing a baby on their stomach while awake) as a physical activity for non-locomotor infants. However, parents often do not fully understand specific methods for fulfilling tummy time recommendations, then did not implement tummy time in the early stage of life. Aim of the study: The study aimed to determine the realistic dosage of daily tummy time for parents and infants of various ages. Methods: A total of 11 infants (7 girls, 4 boys, start age 61. 5days) participated in the intervention. Accumulate 60 minutes of tummy time was requested throughout the day. Results: Infants completed the intervention (achievement of sitting milestone age) at an average of 182.18 days old. The average duration of intervention days was 120.63 days. The average daily practice was 50.12 minutes. During the intervention, the percentage of completed days infants meet their required dosage was an average of 46.3 %. The percentage of missing days infants did not practice tummy time at all was an average of 18.64%. The percentage of days that infants did practice tummy time, but were under the required dosage was an average of 23.51%. Conclusion: It was evident that the prescribed dosage of daily practice was a too ambitious goal and maybe far from realistic for non-locomotor infants. Keywords: tummy time, early exercise, physical activity, motor development
A Survey of Male Sexual Functioning in the General Population in the Northern Netherlands
Authors: Lammerink Ellen , Bock Truuske , Beek Andre , Bergh Fons , Mourits Marian
Published: June 2021

Aim. To describe age-related male sexual functioning in a representative Dutch general population using internationally accepted and validated questionnaires. Material and Methods. A random selection of 1404 men from the general populations in the Netherlands were asked to participate. Men primarily completed the International Index of Erectile Function (IIEF), but also provide medical history, details of daily activities, the Body Image Scale, the SF-36 Health Survey, the Hospital Anxiety and Depression Scale, and the Multidimensional Fatigue Inventory. Participants’ representativeness was assessed by comparison with data from the Dutch Central Agency for Statistics and the Dutch Health Monitor. Main outcome measurements were the age-related domain scores of the IIEF. Results. Responses were obtained from 333 of 1404 men (24%). Participant characteristics were broadly comparable to those of the Dutch population, except for underreporting homosexuals, immigrants, age <40 years and mid-level educations. Overall, 39% of respondents were sexually inactive, and inactivity increased significantly with advancing age. All IIEF domain scores decreased markedly with increasing age, except for overall satisfaction. The prevalence rates of mild and severe erectile dysfunction were 22% and 5%, respectively, and both increased significantly with advancing age. Conclusion. Four of the IIEF domain scores (i.e., erectile function, orgasmic function, sexual desire, and intercourse satisfaction) decrease with increasing age, whereas the overall satisfaction domain scores remain stable throughout life.
Functional Improvement in -Islet Cells and Hepatocytes with Decreasing Deuterium from Low Carbohydrate Intake in a Type-II Diabetic
Authors: Jones Edwin , Jardet Cortney
Published: June 2021

A 59-year-old patient with a 18-year history of type-II diabetes is presented who showed dramatic improvements to glucose tolerance tests and increased fasting hepatic glucose production with systemic deuterium depletion. Deuterium, which is well known to decrease the efficiency of the ATP syntheses nanomotors, is likely the mechanism leading to the systemic changes to both insulin and hepatic glucose production in the pancreas and liver, respectively. Systemic deuterium depletion occurs with consumption of low carbohydrate (keto) diets and deuterium depleted water.