bluuebunny/crossref_metadata_2025 huggingface dataset:
Centralidades y nuevas actividades en la "Raya" ibérica
Authors: López Trigal Lorenzo
Published: November 2016

La frontera internacional hispano-portuguesa, conocida como la Raya ibérica, es, desde la integración europea de ambos Estados, un espacio de cooperación transfronteriza donde desde el análisis espacial se pueden abordar múltiples fenómenos y problemas relevantes. En este artículo se presta atención, en primer término, a las comunicaciones y flujos fronterizos así como a la red de lugares centrales en sus distintos niveles jerárquicos y formas de asentamiento, en forma de complejos conurbados y enclaves urbanos a lo largo de corredores transnacionales o de pasos fronterizos de circulación local. En segundo lugar, se analizan nuevas o renovadas actividades económicas, surgidas en el contexto de la cooperación transfronteriza y clasificadas en tipologías: comercial, patrimonial o termal, y de acuerdo a los nuevos comportamientos de los consumidores y los destinos de los viajeros en estos espacios y lugares fronterizos, que conducen a un proceso de desfronterización, que cabe prever tenga repercusión en la ordenación territorial y la gobernanza de este amplio territorio.
Irlanda libre (y otros textos)
Authors: Castro Plácido
Published: November 2016

Los tres textos seleccionados ilustran algunos de los elementos fundamentales en el pensamiento de Plácido Castro. El primero de ellos versa sobre Irlanda, la nación que para los galeguistas de la época era el espejo en el que mirarse. Para el autor, la integración de Irlanda en la Commonweatlh asegura el disfrute de sus libertades, al tiempo que se beneficia de ventajas comerciales o de la seguridad que le ofrece el Imperio. No obstante, cuando entra en juego el factor sentimental (el deber de los diputados irlandeses de jurar fidelidad a la corona británica) se pone de relevancia la fuerza del nacionalismo. En el segundo, además de Irlanda, el autor se refiere a Escocia y Gales como naciones celtas, hermanas en este sentido de Galicia. El celtismo, otro tema recurrente en el galeguismo, perviviría en el pueblo inculto, verdadero garante de las esencias nacionales. Por último, el tercer artículo da cuenta de la intervención de Castro en representación del Partido Galeguista en el IX Congreso de nacionalidades europeas, celebrado en Berna en 1933. Este momento ha venido a considerarse clave en el reconocimiento internacional de Galicia.
The Efficacy of Problem-Based Learning in an Instrumental Analyse Laboratory
Authors: Seyhan Hatice Güngör
Published: November 2016

In the context of the study, an instrumental analysis laboratory course offering Problem-Based Learning (PBL) was designed as an alternative to traditional laboratory practices. The study was conducted with a total of 36 volunteer, prospective chemistry teachers consisting of fourth year undergraduates and graduates. While PBL activities were conducted with 19 of the prospective teachers, instrumental analysis laboratory activities were conducted with 17 of them using the traditional approach. The first aim of this study was to determine the levels of perception of problem-solving ability and self-regulatory learning strategies of prospective teachers after and before all the applications. The second aim was to compare the effects of PBL instrumental analyze laboratory course and traditional instrumental analyze laboratory course on the perceptions of problem-solving ability and self-regulatory strategies of prospective teachers. A pre-test-post-test control group design was used. In this study, data were obtained using the “Problem Solving Inventory (PSI)” and “Self-Regulatory Strategy Scale (SRSS)”. The pretest-posttest results of the SRRS test showed that the prospective teachers in the experimental group used self-regulatory learning strategies more often when compared to the ones in the control group. According to the results obtained within the scope of the study, it can be said that the effect of PBL on the perception levels of problem solving skills and self-regulatory learning skills of prospective teachers is more effective than the traditional laboratory teaching application.
Enkele kanttekeningen bij het wetsvoorstel bestuur en toezicht rechtspersonen
Authors: Bartman S.M. , de Groot C. , Nijland J. , Wuisman I.S.
Published: November 2016

Enkele kanttekeningen bij het wetsvoorstel bestuur en toezicht rechtspersonen

Met het wetsvoorstel voor de Wet bestuur en toezicht rechtspersonen wordt beoogd de kwaliteit van bestuur en toezicht bij verenigingen, coöperaties, onderlinge waarborgmaatschappijen en stichtingen te verbeteren. In dit artikel bespreken de auteurs kort enkele aspecten van het wetsvoorstel in het licht van de doelstelling en de bruikbaarheid in de praktijk.
Versteviging van risicomanagement in het perspectief van de herziening van de Nederlandse Corporate Governance Code
Authors: Koster H.
Published: November 2016

Versteviging van risicomanagement in het perspectief van de herziening van de Nederlandse Corporate Governance Code

In dit artikel gaat de auteur in op de voorgestelde wijzigingen van de Nederlandse Corporate Governance Code op het terrein van risicomanagement. De auteur is positief over de voorgestelde wijzigingen. Wel zijn nog enkele verbeteringen mogelijk.
Rechtsgeldigheid en doorwerking van een aandeelhoudersovereenkomst in de persoonsgebonden BV: een stappenplan voor de praktijk
Authors: de Leeuw R.
Published: November 2016

Rechtsgeldigheid en doorwerking van een aandeelhoudersovereenkomst in de persoonsgebonden BV: een stappenplan voor de praktijk

Zowel de literatuur als de rechtspraak geeft geen blijk van een helder toetsingskader voor de beoordeling van de rechtsgeldigheid en doorwerking van aandeelhoudersovereenkomsten. Dit artikel beschrijft een eenduidig toetsingskader (inclusief schematisch stappenplan) waarmee een rechter, notaris of advocaat kan beoordelen of een aandeelhoudersovereenkomst geldig is, en zo ja, of deze in het concrete geval doorwerkt in de vennootschap.
De aansprakelijkheid van de moderne commanditaire vennoot
Authors: van Nuland J.E.
Published: November 2016

De aansprakelijkheid van de moderne commanditaire vennoot

De Werkgroep Personenvennootschappen presenteerde onlangs haar rapport betreffende een nieuwe wettelijke regeling voor de personenvennootschappen. Dit artikel bespreekt de aansprakelijkheid van de commanditaire vennoot in de voorgestelde regeling. Na een korte weergave van de huidige regeling wordt de voorgestelde regeling ontleed en van enkele kanttekeningen voorzien.
El retroceso en la protección social de los trabajadores de edad en materia de desempleo y jubilación
Authors: Esteban Legarreta Ricardo , Gala Durán Carolina
Published: November 2016

El artículo aborda los principales rasgos que han acompañado a las últimas reformas en materia de protección por desempleo de los trabajadores de edad y de la jubilación, especialmente de la jubilación anticipada. El texto expone los principales rasgos del sistema español de protección por desempleo, comenzando por una explicación del nivel contributivo de protección, para pasar a continuación a un análisis más pormenorizado de los subsidios por desempleo, destacando en particular el papel representado por los subsidios de mayores de 45 años y, especialmente,  por el subsidio destinado a mayores de 55 años. A este respecto, se subrayan de modo especial las reformas regresivas experimentadas por este último subsidio. A continuación, el artículo traza las grandes líneas de la reforma de la jubilación del periodo 2011-2013,  destacando su objetivo fundamental: la prolongación de la presencia de los trabajadores de edad en el mercado de trabajo. De ahí, se pasa a la descripción de los dos tipos de jubilación anticipada resultantes de las reformas de 2011-2013 y de las condiciones de acceso. Tras una presentación general de la jubilación anticipada, se abordan las características generales de  la jubilación anticipada por reestructuración de empresa, con un alcance más restrictivo y, a continuación se abordan las características generales de la nueva jubilación anticipada voluntaria, con condiciones más duras y de alcance más general.
Crisis económica, austeridad y sus efectos en las transiciones laborales en mercado de trabajos flexibles: los ejemplos de España y el Reino Unido
Authors: López-Andreu Martí
Published: November 2016

La gran recesión de 2007 ha afectado de forma muy intensa los mercados de trabajo europeos. Al mismo tiempo, diferentes países han implementado desde 2010 paquetes de austeridad que han afectado la regulación del empleo, las políticas sociales, y el sector público. El presente artículo analiza los casos de dos países que desde diferentes modelos de empleo y variedades institucionales  se han visto fuertemente afectados por la crisis económica y que se encuentran al frente de las políticas de austeridad: España y el Reino Unido. A través de los datos del EU-SILC se analiza como los cambios en el contexto económico e institucional afectan a las transiciones entre diferentes situaciones en el mercado de trabajo: empleo, desempleo, educación y tareas domésticas/otras formas de inactividad. Se concluye que el contexto ha afectado fuertemente la frecuencia y perfiles de las transiciones y que durante el periodo de austeridad se han aumentado las dinámicas de inseguridad y precariedad en ambos países, y que igualmente se han reducido las opciones de los grupos con menos recursos.
Regressing basal-cell carcinoma masquerading as benign lichenoid keratosis
Authors: Kulberg Aleksandra , Weyers Wolfgang
Published: November 2016

Background: Benign lichenoid keratosis (BLK, LPLK) is often misdiagnosed clinically as superficial basal-cell carcinoma (BCC), especially when occurring on the trunk. However, BCCs undergoing regression may be associated with a lichenoid interface dermatitis that may be misinterpreted as BLK in histopathologic sections.

Methods: In order to assess the frequency of remnants of BCC in lesions interpreted as BLK, we performed step sections on 100 lesions from the trunk of male patients that had been diagnosed as BLK.

Results: Deeper sections revealed remnants of superficial BCC in five and remnants of a melanocytic nevus in two specimens. In the original sections of cases in which a BCC showed up, crusts tended to be more common, whereas vacuolar changes at the dermo-epidermal junction and melanophages in the papillary dermis tended to be less common and less pronounced.

Conclusions: Lesions from the trunk submitted as BCC and presenting histopathologically as a lichenoid interface dermatitis are not always BLKs. Although no confident recommendations can be given on the basis of this limited study, deeper sections may be warranted if lesions are crusted and/or associated with only minimal vacuolar changes at the dermo-epidermal junction and no or few melanophages in the papillary dermis.
The Common European Framework of Reference for Languages: a European framework for foreign language speech development
Authors: Beinhoff Bettina
Published: November 2016

Author/s

Bettina BeinhoffAnglia Ruskin University Cambridge, United Kingdom

 

ABSTRACT

This paper explores the representation of speech development and particularly perceptive skills in the CEFR level descriptions. The speech-related CEFR sections and related level descriptions are vague and none of the assumptions made therein (such as the supposed linear progression between levels) have been sufficiently tested yet. This paper presents an exploratory study on speech perception in language learners at different levels of proficiency and from different first language (L1) backgrounds (Spanish and German). The study is based on transcriptions in response to short narratives, and investigates what kind of influence listeners’ levels of proficiency in the second language (in this case English) and their L1 backgrounds have on how intelligibility is perceived. The results suggest that proficiency levels and L1 background do indeed influence intelligibility (though not always as anticipated) and partially confirm the idea of a linear progression as proposed in the CEFR.
Motivation and constraints of illocution in the Lexical Constructional Model. The case of the Aux NP construction.
Authors: Del Campo Martínez Nuria
Published: November 2016

Author/s

Nuria del Campo MartínezUniversidad de La Rioja, Spain

 

ABSTRACT

This article addresses the motivation and constraints of illocutionary meaning production. Within the framework of the Lexical Constructional Model (LCM), I explore how our knowledge of illocution is understood in terms of high-level situational models which are activated to produce speech act meaning and the way such operations motivate the conventionalized value of linguistic expressions. In so doing, I analyze the realization procedures of the Aux NP construction in relation to their potential to exploit the semantic base of requestive acts. I will study the most conventional linguistic realizations of the construction and explore the way in which such realizations are used to produce a requestive meaning. The resulting account provides a comprehensive understanding of the constructional nature of illocutionary meaning on the basis of naturally occurring data.
English-Medium Instruction at Universities: Global Challenges
Authors: Meijer Annemieke
Published: November 2016

Reviewed by Annemieke MeijerUniversity College Utrecht, The Netherlands

 

1. INTRODUCTION

This collection of articles is an interesting and timely addition to the growing literature on the use of English as the language of instruction at universities in non-native contexts. In the past two decades, EMI (English-Medium Instruction, as the educational practice tends to be called when referring to the tertiary level, as opposed to the more thought-through pedagogical approach of Content and Language Integrated Learning or CLIL at secondary level) has caught on in many different countries and settings.
Revisiting pragmatic tests in the FL context: Towards interactive tests to examine speech act performance
Authors: Beltrán Palanques Vicent
Published: November 2016

Author/s

Vicent Beltrán PalanquesUniversitat Jaume I, Spain

 

ABSTRACT

The aim of this study is to explore the task effect of two different research methods, namely those of interactive discourse completion tasks/tests (IDCTs) and role-play tasks (RPTs). The two research methods employed in this study adopt an interactive approach that allows participants to freely interact not only in the oral mode but also in the written mode. This paper compares the apology strategies elicited by means of IDCTs and in RPTs in terms of strategy length, amount of strategies and classification of strategies across the two elicitation techniques. Results from this comparison will be presented and discussed, and pedagogical implications suggested.
Synaptic transmission parallels neuromodulation in a central food-intake circuit
Authors: Schlegel Philipp , Texada Michael J , Miroschnikow Anton , Schoofs Andreas , Hückesfeld Sebastian , Peters Marc , Schneider-Mizell Casey M , Lacin Haluk , Li Feng , Fetter Richard D , Truman James W , Cardona Albert , Pankratz Michael J
Published: November 2016

NeuromedinU is a potent regulator of food intake and activity in mammals. In Drosophila, neurons producing the homologous neuropeptide hugin regulate feeding and locomotion in a similar manner. Here, we use EM-based reconstruction to generate the entire connectome of hugin-producing neurons in the Drosophila larval CNS. We demonstrate that hugin neurons use synaptic transmission in addition to peptidergic neuromodulation and identify acetylcholine as a key transmitter. Hugin neuropeptide and acetylcholine are both necessary for the regulatory effect on feeding. We further show that subtypes of hugin neurons connect chemosensory to endocrine system by combinations of synaptic and peptide-receptor connections. Targets include endocrine neurons producing DH44, a CRH-like peptide, and insulin-like peptides. Homologs of these peptides are likewise downstream of neuromedinU, revealing striking parallels in flies and mammals. We propose that hugin neurons are part of an ancient physiological control system that has been conserved at functional and molecular level.
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
Authors: Verissimo Carla S , Overmeer René M , Ponsioen Bas , Drost Jarno , Mertens Sander , Verlaan-Klink Ingrid , Gerwen Bastiaan van , van der Ven Marieke , Wetering Marc van de , Egan David A , Bernards René , Clevers Hans , Bos Johannes L , Snippert Hugo J
Published: November 2016

Colorectal cancer (CRC) organoids can be derived from almost all CRC patients and therefore capture the genetic diversity of this disease. We assembled a panel of CRC organoids carrying either wild-type or mutant RAS, as well as normal organoids and tumor organoids with a CRISPR-introduced oncogenic KRAS mutation. Using this panel, we evaluated RAS pathway inhibitors and drug combinations that are currently in clinical trial for RAS mutant cancers. Presence of mutant RAS correlated strongly with resistance to these targeted therapies. This was observed in tumorigenic as well as in normal organoids. Moreover, dual inhibition of the EGFR-MEK-ERK pathway in RAS mutant organoids induced a transient cell-cycle arrest rather than cell death. In vivo drug response of xenotransplanted RAS mutant organoids confirmed this growth arrest upon pan-HER/MEK combination therapy. Altogether, our studies demonstrate the potential of patient-derived CRC organoid libraries in evaluating inhibitors and drug combinations in a preclinical setting.
Neural circuitry coordinating male copulation
Authors: Pavlou Hania J , Lin Andrew C , Neville Megan C , Nojima Tetsuya , Diao Fengqiu , Chen Brian E , White Benjamin H , Goodwin Stephen F
Published: November 2016

Copulation is the goal of the courtship process, crucial to reproductive success and evolutionary fitness. Identifying the circuitry underlying copulation is a necessary step towards understanding universal principles of circuit operation, and how circuit elements are recruited into the production of ordered action sequences. Here, we identify key sex-specific neurons that mediate copulation in Drosophila, and define a sexually dimorphic motor circuit in the male abdominal ganglion that mediates the action sequence of initiating and terminating copulation. This sexually dimorphic circuit composed of three neuronal classes – motor neurons, interneurons and mechanosensory neurons – controls the mechanics of copulation. By correlating the connectivity, function and activity of these neurons we have determined the logic for how this circuitry is coordinated to generate this male-specific behavior, and sets the stage for a circuit-level dissection of active sensing and modulation of copulatory behavior.
A tale of two journals or how Elsevier pushed open access in Linguistics
Authors: Krämer Martin , Rooryck Johan
Published: November 2016

Watch the VIDEO of the presentation.In this talk I provide the background on the transition of a top journal in Linguistics to open access and discuss open access publishing in Linguistics and the problems of this particular transition.The journal Lingua was hosted and marketed by Elsevier which charges substantial subscription fees for its journals and charges authors who want to have their articles published as open access. In the fall of 2015, the editors of the journal wrote a letter to their publishing house Elsevier to express their discomfort with the pricing policy for their journal and asking for a more reasonable policy. Elsevier's reaction to this letter led to the stepping-down of the editors, followed immediately by the complete editorial board. The entire academic Lingua team immediately founded a new journal, Glossa: a journal of general linguistics, which is completely Open Access, published by Ubiquity Press and funded through the Open Library of Humanities. This new foundation was necessary since Elsevier regards Lingua as one of their products and is continuing to publish the journal with a new editorial team.The case received quite some media attention, among others Times Higher Education, Inside Higher Education, The Independent, Slate, and Wired reported. In this talk I will provide the details of the story and discuss commercial and open access publishing in the relatively small field of Linguistics. The conclusion is that it is doable to move even a high profile journal out from behind a huge paywall. Apparently, the Norwegian higher education system isn't quite rigged for this kind of fast change yet if it involves movement of expertise from one label to another rather than movement of the label. While the NSD has approved Glossa this fall, it was granted only the lower level of the system, while Lingua was, and still is, at the top level.
Electrical hysteresis in p-GaN metal–oxide–semiconductor capacitor with atomic-layer-deposited Al2O3 as gate dielectric
Authors: Zhang Kexiong , Liao Meiyong , Imura Masataka , Nabatame Toshihide , Ohi Akihiko , Sumiya Masatomo , Koide Yasuo , Sang Liwen
Published: November 2016

The electrical hysteresis in current–voltage (I–V) and capacitance–voltage characteristics was observed in an atomic-layer-deposited Al2O3/p-GaN metal–oxide–semiconductor capacitor (PMOSCAP). The absolute minimum leakage currents of the PMOSCAP for forward and backward I–V scans occurred not at 0 V but at −4.4 and +4.4 V, respectively. A negative flat-band voltage shift of 5.5 V was acquired with a capacitance step from +4.4 to +6.1 V during the forward scan. Mg surface accumulation on p-GaN was demonstrated to induce an Mg–Ga–Al–O oxidized layer with a trap density on the order of 1013 cm−2. The electrical hysteresis is attributed to the hole trapping and detrapping process in the traps of the Mg–Ga–Al–O layer via the Poole–Frenkel mechanism.
Enhancing thermally induced effects on atomic force microscope cantilevers using optical microcavities
Authors: Vy Nguyen Duy , Iida Takuya
Published: November 2016

A theory of enhancing thermally induced effects on atomic force microscope cantilevers with respect to the input power is proposed. An optical microcavity is used to increase the absorbed power and radiation pressure on thin films. We show that the response to the input power is enhanced up to an order of magnitude for cantilevers of ∼200 µm in length and ∼0.5 µm in thickness. A decrease in the absorbed power in the presence of cantilever deflection increases system endurability with respect to the input power. The study gives methods for amplifying and tuning vibration amplitudes in amplitude modulation modes with high sensitivity and low controlling input power.
jicbioimage: a tool for automated and reproducible bioimage analysis
Authors: Olsson Tjelvar S. G. , Hartley Matthew
Published: November 2016

There has been steady improvement in methods for capturing bioimages. However analysing these images still remains a challenge. The Python programming language provides a powerful and flexible environment for scientific computation. It has a wide range of supporting libraries for image processing but lacks native support for common bioimage formats, and requires specific code to be written to ensure that suitable audit trails are generated and analyses are reproducible. Here we describe the development of a Python tool that: (1) allows users to quickly view and explore microscopy data; (2) generate reproducible analyses, encoding a complete history of image transformations from raw data to final result; and (3) scale up analyses from initial exploration to high throughput processing pipelines, with a minimal amount of extra effort. The tool, jicbioimage, is open source and freely available online athttp://jicbioimage.readthedocs.io.
Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice
Authors: Masocha Willias
Published: November 2016

Paclitaxel, a chemotherapeutic agent, causes neuropathic pain whose supraspinal pathophysiology is not fully understood. Dysregulation of sodium channel expression, studied mainly in the periphery and spinal cord level, contributes to the pathogenesis of neuropathic pain. We examined gene expression of sodium channel (Nav) subunits by real time polymerase chain reaction (PCR) in the anterior cingulate cortex (ACC) at day 7 post first administration of paclitaxel, when mice had developed paclitaxel-induced thermal hyperalgesia. The ACC was chosen because increased activity in the ACC has been observed during neuropathic pain. In the ACC of vehicle-treated animals the threshold cycle (Ct) values for Nav1.4, Nav1.5, Nav1.7, Nav1.8 and Nav1.9 were above 30 and/or not detectable in some samples. Thus, comparison in mRNA expression between untreated control, vehicle-treated and paclitaxel treated animals was done for Nav1.1, Nav1.2, Nav1.3, Nav1.6, Naxas well as Navβ1–Navβ4. There were no differences in the transcript levels of Nav1.1–Nav1.3, Nav1.6, Nax, Navβ1–Navβ3 between untreated and vehicle-treated mice, however, vehicle treatment increased Navβ4 expression. Paclitaxel treatment significantly increased the mRNA expression of Nav1.1, Nav1.2, Nav1.6 and Nax, but not Nav1.3, sodium channel alpha subunits compared to vehicle-treated animals. Treatment with paclitaxel significantly increased the expression of Navβ1 and Navβ3, but not Navβ2 and Navβ4, sodium channel beta subunits compared to vehicle-treated animals. These findings suggest that during paclitaxel-induced neuropathic pain (PINP) there is differential upregulation of sodium channels in the ACC, which might contribute to the increased neuronal activity observed in the area during neuropathic pain.
Going from theory to practice: Succeeding with OTPs in corrections
Authors: Knopf Alison
Published: September 2024

With her compassion and knowledge, Linda Hurley, CEO of CODAC Behavioral Healthcare in Rhode Island, is able to convince corrections staff of the benefits of methadone and buprenorphine. But it isn't easy.
Kentucky treatment backers mobilize to oppose access‐limiting proposals
Authors: Enos Gary
Published: September 2024

By many measures, policy leaders in Kentucky have taken important steps to combat opioid overdose deaths and related challenges. State leaders embraced Medicaid expansion, in a region of the country where several holdout states remain. Regulations that would have severely limited access to care during the COVID‐19 pandemic were lifted. A record number of syringe services programs statewide have made a difference in curbing infectious disease transmission.
Experimental, but effective: Noninvasive brain stimulation for addiction
Authors: Knopf Alison
Published: September 2024

In a presentation by Antonello Bonci, M.D., at the Cape Cod Symposium on Addictive Disorders meeting in Massachusetts this month, work by Italian researchers on the use of noninvasive brain stimulation to treat addiction was a popular feature. “We studied it in rats first,” he said. The lab animals learned that if they self‐administered cocaine, they would get a foot shock, and 70% of the rats stopped pressing the lever for cocaine. But 30% kept running around waiting for the lever to come out, and kept pressing it, getting the shock. These were the addicted rats.”
CDC data show some relief in overdose deaths
Authors: Knopf Alison
Published: September 2024

The most recent data from the federal Centers for Disease Control and Prevention indicate that the death rate from overdoses took a dip, for the first time in years. It's still bad news. But possibly, if the trend continues, good news.
Obituary: Kenneth R. Warren, Ph.D.
Authors: Knopf Alison
Published: September 2024

Last month, Kenneth R. Warren, Ph.D., died. The deputy director of the National Institute on Alcohol Abuse and Alcoholism (NIAAA) since 2008, Warren was also acting director from 2008 to 2014. He retired in 2015.
Watch those OD numbers!
Authors: Knopf Alison
Published: September 2024

In a comment entitled “the new math,” Rob Kent, former general counsel for the federal Office of National Drug Control Policy, and before that general counsel for the New York Office of Addiction Services and Supports (OASAS), sent us this.
Wine Tourism as a Catalyst for Sustainable Performance: The Mediating Role of Corporate Legitimacy and Green Innovation
Authors: Martínez‐Falcó Javier , Sánchez‐García Eduardo , Marco‐Lajara Bartolomé , Millán‐Tudela Luis A.
Published: September 2024

This study aims to explore the influence of Wine Tourism (WT) on the Sustainable Performance (SP) of wineries in Spain. It particularly investigates how Corporate Social Legitimacy (CSL) and Green Innovation (GI) may act as intermediary factors in this relationship. Additionally, the research considers the age of the winery, its size, and whether it is part of a protected designation of origin as control variables to enhance the accuracy of the identified cause‐and‐effect relationships. This research introduces a theoretical framework, grounded in prior literature, and examines it through structural equation modeling. The analysis is based on data gathered from 196 wineries in Spain, collected over the period from September 2022 to January 2023. The results of this study highlight a notable and positive correlation between the advancement of WT and the SP of wineries in Spain. Additionally, the study uncovers that CSL and GI play a partially mediating role in this connection. The uniqueness and significance of this study can be attributed to several crucial factors. First, it enhances the understanding and knowledge regarding the advantages associated with WT development. Second, no prior research has conducted a comprehensive study on the WT development as a catalyst for economic, social, and environmental outcomes within the context of Spanish wineries. Third, to the best of the authors' knowledge, no previous study has simultaneously analyzed the mediating role of CSL and GI as mediators in the relationship between WT development and the SP of wineries.
Work‐related injuries and illnesses (WRII) presenting to Illinois hospitals, 2017−2021: The importance of emergency department (ED) data
Authors: Shannon Brett , Ryder Courtney , Abasilim Chibuzor , Almberg Kirsten , Bonney Tessa , Friedman Lee S.
Published: September 2024

Objectives

Research characterizing work‐related injuries and illnesses (WRII) has predominantly focused on inpatients and deaths, despite evidence that 4% of WRII are admitted as inpatients and deaths are less than 0.2% of acute WRII. Our aim is to determine the usefulness of incorporating emergency department (ED) hospital data into current occupational health surveillance systems.

Methods

Data on ED and admitted WRII treated in Illinois hospitals from 2017 to 2021 were analyzed. Demographic characteristics, primary diagnosis, procedures undertaken, and unique patient estimates are described. Multivariable logistic regression models were developed to evaluate predictors of treatment in the ED and multivariable median regression models determined associations of total hospital charges.

Results

Between 2017 and 2021 there were 488,033 hospital presentations (95.9% nonadmissions) for WRII in Illinois, equating to a crude annual population rate of 1502.1/100,000. Non‐Hispanic Whites (NHW) were disproportionately treated for illnesses, while Hispanic or Latino workers were disproportionately treated for injuries. African‐Americans had the highest rate of ED emergent presentations (incident rate ratio [IRR] = 1.3, ref = NHW) and were less likely to be admitted for emergent presentations (IRR = 0.7, ref = NHW). ED presentations were more likely to be female, present with an injury, and at a rural, versus urban, hospital. Radiological investigations compromised the majority of procedures for nonadmitted patients (n = 403,317), and 94.8% were coded for a body region

Conclusion

Between 2017 and 2021 in Illinois, there were nearly 500,000 hospital visits charged to workers' compensation totaling over US$ four billion. ED data provide additional insights into work‐related chronic conditions, health disparities, and the usage of diagnostic and therapeutic procedures for WRII.
Benefits and risks of FDA‐approved amyloid‐targeting antibodies for treatment of early Alzheimer's disease: Navigating clinician‐patient engagement
Authors: Rentz Dorene M. , Aisen Paul S. , Atri Alireza , Hitchcock Janice , Irizarry Michael , Landen Jaren , Matthews Brandy R. , Miller David S. , Mahinrad Simin , Napoli Salvatore , Okhravi Hamid R. , Petersen Ronald C. , Siemers Eric R. , Weber Christopher J. , Weisman David C. , Carrillo Maria C.
Published: September 2024

The emergence of the United States Food and Drug Administration (FDA)‐approved amyloid‐targeting therapies for Alzheimer's disease challenges clinicians and healthcare providers with a transformative landscape. Effectively communicating the risks, benefits, burdens, costs, and available support associated with these novel disease‐modifying treatments to patients, families, and other healthcare providers is essential but complex. In response, the Alzheimer's Association's Clinical Meaningfulness Workgroup has proposed language surrounding treatment eligibility, benefits, amyloid‐related imaging abnormalities (ARIA), apolipoprotein E (APOE) genotyping, and treatment costs, serving as a resource to healthcare professionals in navigating discussions with patients and their families. As the landscape evolves with the approval of new Alzheimer's therapies, this resource stands poised for updates, ensuring its continued relevance in facilitating informed and meaningful patient‐provider dialogues.

Highlights

Effective communication of risks, benefits, burdens, and costs of FDA‐approved amyloid‐targeting antibodies is essential to patients, families, and healthcare providers.

The Alzheimer's Association's Clinical Meaningfulness Workgroup provides language for physicians and healthcare providers around treatment eligibility, benefits, ARIA, APOE genotyping, and treatment costs.

This supplementary resource may be updated as new AD therapies become approved.
Electrodeposition of Manganese (III) Phthalocyanine/ Reduced Graphene Oxide for Asymmetric Supercapacitor Devices
Authors: Yenilmez Hacer Yasemin , Farajzadeh Öztürk Nazlı , Budak Özlem , İpsiz Öney Özlem , Koca Atıf , Altuntaş Bayır Zehra
Published: September 2024

In this study, two novel tetra‐substituted manganese (III) phthalocyanines bearing (9H‐carbazol‐2‐yl)oxy groups on peripheral (1) or non‐peripheral (2) positions were prepared and used for modification of reduced graphene oxide (rGO) by applying a simple one‐step electrodeposition technique for the first time. The manganese (III) phthalocyanines (MnPcs) were electropolymerized and graphene oxide was electrochemically converted into reduced graphene oxide simultaneously. Subsequently, an rGO‐MnPc hybrid structure was formed directly on the NiF electrode (substrate) via layer‐by‐layer assembly. Additionally, the effect of substituent position on the charge storage capacity of the prepared hybrid capacitive candidates was investigated. The fabricated hybrid electrodes exhibited remarkable electrochemical performance due to the combination of manganese (III) phthalocyanines and reduced graphene oxide. The NiF/rGO2‐2 electrode exhibited the highest specific capacitance (512.4 F g−1) at 0.5 A g−1 and the remained specific capacitance was obtained 88.1 % after 5000 consecutive charge‐discharge cycles. An asymmetric supercapacitor (ASC) was constructed from rGO2‐2 as the positive electrode and rGO as the negative electrode with a working potential of 1.5 V. The as‐prepared device delivered a specific energy of 17.4 Wh kg−1 at 350 W kg−1. Hence, manganese (III) phthalocyanine‐reduced graphene oxide electrodes can be considered outstanding materials for energy storage applications in the future.
Breast cancer immunotherapy: Realities and advances
Authors: Medina Aixa , Carballo Jeismar , González‐Marcano Eglys , Blanca Isaac , Convit Ana F.
Published: September 2024

Breast cancer (BC) is the most common malignant tumor and the main cause of death in women worldwide. With increased knowledge regarding tumor escape mechanisms and advances in immunology, many new antitumor strategies such as nonspecific immunotherapies, monoclonal antibodies, anticancer vaccines, and oncolytic viruses, among others, make immunotherapy a promising approach for the treatment of BC. However, these approaches still require meticulous assessment and readjustment as resistance and modest response rates remain important barriers. In this article, we aim to summarize the most recent data available in BC immunotherapy to include the results of ongoing clinical trials and approved therapies used as monotherapies or in combination with conventional treatments.
Studies on the Bioactivity (Antioxidant, Enzyme Inhibitory, Antimicrobial and Cytotoxic) and Chemical Composition of Aqueous Extracts of Some Plant Species Collected from Turkmenistan
Authors: Korpayev Serdar , Zengin Gökhan , Glamočlija Jasmina , Soković Marina , Aničić Neda , Gašić Uroš , Stojković Dejan , Agamuradov Mirap , Agamyradova Guljan
Published: September 2024

Alhagi persarum (AP), Alhagi persarum flowers (APF), Ephedra equisetina (EE) and Glycyrrhiza glabra root (GGR) have been utilized in Central Asian folk medicine for centuries. In the present study, antioxidant, enzyme inhibition, antimicrobial and cytotoxic effects the aqueous extracts of these plants were studied. In addition, 23 compounds were identified in the extracts using UHPLC‐DAD‐QqQ‐MS/MS analysis. The four plant samples demonstrated promising antioxidant activities in vitro for scavenging of 2, 20‐azinobis‐(3‐ethylbenz‐thiazoline‐6‐sulphonate) radical (ABTS), 1, 1‐diphenyl‐2‐picrylhydrazyl radical (DPPH), and total reducing power. AP (DPPH: 47.39 mg TE/g; ABTS:108.58 mg TE/g; CUPRAC: 117.41 mg TE/g; FRAP: 82.22 mg TE/g) and EE (DPPH: 46.75 mg TE/g; ABTS: 110.51 mg TE/g; CUPRAC: 140.77 mg TE/g; FRAP: 91.00 mg TE/g) displayed the strongest antiradical and reduction abilities in the test system. In terms of enzyme inhibition efficacy, AP and EE showed higher bioactivity. Aqueous extracts demonstrated the most potent efficacy against eight different bacterial and fungal strains in antibacterial (MIC values: 1.5–4 mg/ml) and antifungal (MIC values: 1–8 mg/ml) testing. Contrary to other activities, these aqueous extracts did not show cytotoxic effects against HaCaT cells. All bioactivities suggested that the plants could be utilized as candidate resources in the food and pharmaceutical industries.
The prognostic impact of tumor deposits in colorectal cancer: More than just N1c
Authors: Bhutiani Neal , Peacock Oliver , Uppal Abhineet , Hu Chung‐Yuan , Bednarski Brian K. , Taggart Melissa W. , Dasari Arvind , Morris Van K. , Kaur Harmeet , Kopetz Scott , Holliday Emma B. , Das Prajnan , You Y. Nancy , Chang George J.
Published: September 2024

Background

The identification of tumor deposits (TD) currently plays a limited role in staging for colorectal cancer (CRC) aside from N1c lymph node designation. The objective of this study was to determine the prognostic impact, beyond American Joint Committee on Cancer N1c designation, of TDs among patients with primary CRC.

Methods

Patients who had resected stage I–III primary CRC diagnosed between 2010 and 2019 were identified from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Cancer‐specific survival (CSS) stratified by TD status and lymph node (N) status was calculated using the Kaplan–Meier method and multivariable Cox proportional hazards regression analyses.

Results

In total, 147,783 patients with primary CRC were identified. TDs were present in 15,444 patients (10.5%). The presence of TDs was significantly associated with adverse tumor characteristics, including advanced pathologic stage, nodal status, and metastasis status. The presence of TDs was associated with worse CSS (hazard ratio [HR], 3.12; 95% confidence interval [CI], 3.02–3.22), as it was for each given N category (e.g., N2a and TD‐negative [HR, 2.50; 95% CI, 2.37–2.64] vs. N2a and TD‐positive [HR, 3.75; 95% CI, 3.49–4.03]). The presence of multiple TDs was also associated with decreased CSS for each given N category compared with a single TD (e.g. N2a with one TD [HR, 3.09; 95% CI, 2.65–3.61] vs. N2a with two or more TDs [HR, 4.32; 95% CI, 3.87–4.82]).

Conclusions

TDs were identified as an independent predictor of a worse outcome in patients with CRC. The presence of TDs confers distinctly different CSS and provides important prognostic information among patients with CRC and warrants further investigation as a unique variable in future iterations of CRC staging.
Proximity to cancer rehabilitation and exercise oncology by geography, race, and socioeconomic status
Authors: Schmitz Kathryn H. , Demanelis Kathryn , Crisafio Mary E. , Kennedy Mary A. , Schwartz Anna L. , Campbell Anna , Gorzelitz Jessica , Wood Kelley C. , Wilson Christopher M. , Scalise Raymond L. , Vincent Alex
Published: September 2024

Background

Cancer rehabilitation and exercise oncology (CR/EO) have documented benefits for people living with and beyond cancer. The authors examined proximity to CR/EO programs across the United States with respect to population density, race and ethnicity, socioeconomic status, and cancer incidence and mortality rates.

Methods

This cross‐sectional study was conducted in 2022–2023. Online searches were initiated to identify CR/EO programs. Geocoding was used to obtain latitudinal and longitudinal geospatial coordinates. Demographic data were abstracted from the 2020 5‐year American Community Survey. Cancer incidence and mortality data were obtained from the Centers for Disease Control and Prevention. US 2013 Rural‐Urban Continuum Code (RUCC) classification was used to define counties as either urban (RUCC 1–3) or rural (RUCC 4–9). Multivariable logistic regression was used to evaluate the association between being far from a program and census‐tract level factors.

Results

In total, 2133 CR/EO programs were identified nationwide. The distance from a program increased with decreasing population density: rural tracts were 17.68 ± 0.24 miles farther from a program compared with urban tracts (p < .001). Program proximity decreased as the neighborhood deprivation index increased (p < .001). Exercise oncology programs were less common than cancer rehabilitation programs in tracts with a larger proportion of minority residents (p < .001).

Conclusions

Prior research has documented that underrepresented populations have worse cancer‐related symptoms and higher cancer mortality. Herein, the authors document their findings that these same populations are less likely to have proximity to CR/EO programs, which are associated with improved cancer‐related symptoms and cancer mortality outcomes. To realize the positive outcomes from CR/EO programming, efforts must focus on supporting expanded programming and sustainable payment for these services.
Using context‐specific evidence to inform resource‐stratified cancer guidelines: A call for a new approach
Authors: Buckle Geoffrey C. , DeBoer Rebecca , Xu Mary Jue , Mrema Alita , Rubagumya Fidel , Velloza Jennifer , Falade Ayo S. , Van Loon Katherine
Published: September 2024

Clinical practice guidelines are widely used in oncology to guide clinical decision making and inform health policy and planning. In recent years, the National Comprehensive Cancer Network and the American Society of Clinical Oncology, as well as other international groups, have developed resource‐stratified guidelines to guide clinicians and policymakers on cancer diagnosis and management in settings with various levels of resource constraints. Current methods for developing resource‐stratified guidelines rely heavily on supporting evidence originating from high‐income countries. In this commentary, the authors discuss limitations of the existing methods to develop resource‐stratified guidelines and offer perspective on ways to strengthen the guidelines and their evidence base. Pulling from conceptual frameworks in the health policy domain, the authors outline a more inclusive approach to evidence synthesis that seeks to integrate the growing volume of cancer research emerging from low‐ and middle‐income countries. The authors also introduce a revised evidence framework that provides transparency into the generalizability of evidence within the guidelines. These changes have the potential to enhance resource‐stratified guidelines and bring us one step closer to the goal of evidence‐based guidelines that are appropriate for diverse settings and unique patient populations across the world.
Influenza vaccine effectiveness in immunocompromised patients with cancer: A Danish nationwide register‐based cohort study
Authors: Amdisen Lau , Pedersen Lars , Abildgaard Niels , Benn Christine Stabell , Cronin‐Fenton Deirdre , Sørup Signe
Published: September 2024

Background

Influenza vaccination is free of charge for Danish citizens with acquired immunodeficiency but recommendations do not specifically target patients with cancer. This study investigated whether influenza vaccination reduces the main outcome of overall mortality and the secondary outcomes of influenza requiring treatment, pneumonia, myocardial infarction, stroke, heart failure, and venous thromboembolism in patients with cancer.

Methods

This was a register‐based nationwide cohort study. Adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs) for overall mortality and secondary outcomes were estimated using Cox proportional hazards models. Analyses were conducted separately for four subgroups: patients aged <65 years with solid tumors, patients aged ≥65 years with solid tumors, patients aged <65 years with hematological cancer, and patients aged ≥65 years with hematological cancer.

Results

A total of 53,249 adult patients with solid tumors who received chemotherapy and 22,182 adult patients with hematological cancer were followed for up to five influenza seasons in the study period of 2007–2018. In the main analysis covering December–March, influenza vaccination was associated with reduced overall mortality in all four subgroups. The reduction was most pronounced in patients with hematological cancer aged <65 years (aHR, 0.66; 95% CI, 0.51–0.87) and smallest in patients with solid tumors aged <65 years (aHR, 0.91; 95% CI, 0.84–0.99). In sensitivity analyses covering January–March, the aHR was 0.87 (95% CI, 0.65–1.16) in patients with hematological cancer aged <65 years and 1.01 (95% CI, 0.92–1.10) in patients with solid tumors aged <65 years. Results for the secondary outcomes were inconclusive.

Conclusions

The results of this study cannot reject that influenza vaccination reduces overall mortality in immunocompromised patients with cancer. The results must be interpreted with caution because of potential unmeasured confounding, which can result in the overestimation of influenza vaccine effectiveness.