bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Highly Oxygenated Bicyclic Carbasugars. Remarkable Difference in the Reactivity of the d-gluco and d-xylo- Derived Trienes
Authors: Witkowski Grzegorz , Potopnyk Mykhaylo A. , Tiara Karolina , Osuch-Kwiatkowska Anna , Jarosz Sławomir
Published: July 2020

2,3,4-Tri-O-benzyl-D-xylopyranose was used as a starting material in the preparation of the corresponding triene, which underwent smooth cyclization to a polyhydroxylated hydrindane, as a single diastereoisomer. The analogous triene prepared from D-glucose did not undergo any cyclization even under high pressure.
Design, Synthesis and Bioactive Evaluation of Oxime Derivatives of Dehydrocholic Acid as Anti-Hepatitis B Virus Agents
Authors: Wei Zhuocai , Tan Jie , Cui Xinhua , Zhou Min , Huang Yunhou , Zang Ning , Chen Zhaoni , Wei Wanxing
Published: July 2020

Oxime derivatives of dehydrocholic acid and its esters were designed for anti-hepatitis B virus (HBV) drugs according to principles of assembling active chemical fragments. Twelve compounds were synthesized from dehydrocholic acid by esterification and oxime formation, and their anti-hepatitis B virus (HBV) activities were evaluated with HepG 2.2.15 cells. Results showed that 5 compounds exhibited more effective inhibition of HBeAg than positive control, among them 2b-3 and 2b-1 showed significant anti-HBV activities on inhibiting secretion of HBeAg (IC50 (2b-3) = 49.39 ± 12.78 μM, SI (2b-3) = 11.03; IC50 (2b-1) = 96.64 ± 28.99 μM, SI (2b-1) = 10.35) compared to the Entecavir (IC50 = 161.24 μM, SI = 3.72). Molecular docking studies showed that most of these compounds interacted with protein residues of heparan sulfate proteoglycan (HSPG) in host hepatocyte and bile acid receptor.
Overcoming Multidrug Resistance: Flavonoid and Terpenoid Nitrogen-Containing Derivatives as ABC Transporter Modulators
Authors: M. F. Gonçalves Bruno , S. P. Cardoso David , U. Ferreira Maria-José
Published: July 2020

Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance protein 1 (MRP1) is highlighted as a prime factor. Natural product-derived compounds are being addressed as promising ABC transporter modulators to tackle MDR. Flavonoids and terpenoids have been extensively explored in this field as mono or dual modulators of these efflux pumps. Nitrogen-bearing moieties on these scaffolds were proved to influence the modulation of ABC transporters efflux function. This review highlights the potential of semisynthetic nitrogen-containing flavonoid and terpenoid derivatives as candidates for the design of effective MDR reversers. A brief introduction concerning the major role of efflux pumps in multidrug resistance, the potential of natural product-derived compounds in MDR reversal, namely natural flavonoid and terpenoids, and the effect of the introduction of nitrogen-containing groups are provided. The main modifications that have been performed during last few years to generate flavonoid and terpenoid derivatives, bearing nitrogen moieties, such as aliphatic, aromatic and heterocycle amine, amide, and related functional groups, as well as their P-gp, MRP1 and BCRP inhibitory activities are reviewed and discussed.
DNA Electrochemical Biosensor Based on Iron Oxide/Nanocellulose Crystalline Composite Modified Screen-Printed Carbon Electrode for Detection of Mycobacterium tuberculosis
Authors: Mat Zaid Mohd Hazani , Che-Engku-Chik Che Engku Noramalina , Yusof Nor Azah , Abdullah Jaafar , Othman Siti Sarah , Issa Rahizan , Md Noh Mohd Fairulnizal , Wasoh Helmi
Published: July 2020

Death from tuberculosis has resulted in an increased need for early detection to prevent a tuberculosis (TB) epidemic, especially in closed and crowded populations. Herein, a sensitive electrochemical DNA biosensor based on functionalized iron oxide with mercaptopropionic acid (MPA-Fe3O4) nanoparticle and nanocellulose crystalline functionalized cetyl trimethyl ammonium bromide (NCC/CTAB) has been fabricated for the detection of Mycobacterium tuberculosis (MTB). In this study, a simple drop cast method was applied to deposit solution of MPA-Fe3O4/NCC/CTAB onto the surface of the screen-printed carbon electrode (SPCE). Then, a specific sequence of MTB DNA probe was immobilized onto a modified SPCE surface by using the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling mechanism. For better signal amplification and electrochemical response, ruthenium bipyridyl Ru(bpy)32+ was assigned as labels of hybridization followed by the characteristic test using differential pulse voltammetry (DPV). The results of this biosensor enable the detection of target DNA until a concentration as low as 7.96 × 10−13 M with a wide detection range from 1.0 × 10−6 to 1.0 × 10−12 M. In addition, the developed biosensor has shown a differentiation between positive and negative MTB samples in real sampel analysis.
Effect of Varying Amine Functionalities on CO2 Capture of Carboxylated Graphene Oxide-Based Cryogels
Authors: Pruna Alina I. , Barjola Arturo , Cárcel Alfonso C. , Alonso Beatriz , Giménez Enrique
Published: July 2020

Graphene cryogels synthesis is reported by amine modification of carboxylated graphene oxide via aqueous carbodiimide chemistry. The effect of the amine type on the formation of the cryogels and their properties is presented. In this respect, ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA), were selected. The obtained cryogels were characterized by Fourier Transformed Infrared spectroscopy, thermogravimetric analysis, X-ray spectroscopy, and Scanning electron microscopy. The CO2 adsorption performance was evaluated as a function of amine modification. The results showed the best CO2 adsorption performance was exhibited by ethylenediamine modified aerogel, reaching 2 mmol g−1 at 1 bar and 298 K. While the total N content of the cryogels increased with increasing amine groups, the nitrogen configuration and contributions were determined to have more important influence on the adsorption properties. It is also revealed that the residual oxygen functionalities in the obtained cryogels represent another paramount factor to take into account for improving the CO2 capture properties of amine-modified graphene oxide (GO)-based cryogels.
Graphene Oxide: Graphene Quantum Dot Nanocomposite for Better Memristic Switching Behaviors
Authors: Li Lei
Published: July 2020

Tristable memristic switching provides the capability for multi-bit data storage. In this study, all-inorganic multi-bit memory devices were successfully manufactured by the attachment of graphene quantum dots (GQDs) onto graphene oxide (GO) through a solution-processable method. By means of doping GQDs as charge-trapping centers, the device indium-tin oxide (ITO)/GO:0.5 wt%GQDs/Ni revealed controllable memristic switching behaviors that were tunable from binary to ternary, and remarkably enhanced in contrast with ITO/GO/Ni. It was found that the device has an excellent performance in memristic switching parameters, with a SET1, SET2 and RESET voltage of −0.9 V, −1.7 V and 5.15 V, as well as a high ON2/ON1/OFF current ratio (103:102:1), and a long retention time (104 s) together with 100 successive cycles. The conduction mechanism of the binary and ternary GO-based memory cells was discussed in terms of experimental data employing a charge trapping-detrapping mechanism. The reinforcement effect of GQDs on the memristic switching of GO through cycle-to-cycle operation has been extensively investigated, offering great potential application for multi-bit data storage in ultrahigh-density, nonvolatile memory.
Fabrication and Characterization of Ceftizoxime-Loaded Pectin Nanocarriers
Authors: Kumar Pawan , Kumar Vinod , Kumar Ravinder , Pruncu Catalin Iulian
Published: July 2020

Ceftizoxime (C13H12N5NaO5S2) is a parenteral, third-generationcephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. In this work, pectin has been used as a nanocarrier for ceftizoxime due to its high biocompatibility and non-toxicity with tunable surface properties. Ceftizoxime-loaded pectin nanocarriers (CPN) were successfully synthesized by the solvent displacement method. Optimization of nanoformulation was done by response surface methodology using Design-Expert software. The optimized formulation examined various in-vitro characterizations such as particle size, morphology, and FTIR studies. TEM results revealed irregular shape nanoparticles within the range of 29–110 nm. The in-vitro drug release using the dialysis method was performed after 24 h where nanoformulation showed sustained drug release. Drug-loaded nanoparticles revealed good antimicrobial activity against Bacillus cereus, Bacillus polymyxa, Enterobacter aerogenes, and Pseudomonas aeruginosa.
Insulin Resistance Is Associated with Reduced Food Odor Sensitivity across a Wide Range of Body Weights
Authors: Poessel Maria , Freiherr Jessica , Wiencke Kathleen , Villringer Arno , Horstmann Annette
Published: July 2020

The worldwide obesity epidemic is a major health problem driven by the modern food environment. Recently, it has been shown that smell perception plays a key role in eating behavior and is altered in obesity. However, the underlying mechanisms of this phenomenon are not well understood yet. Since the olfactory system is closely linked to the endocrine system, we hypothesized that hormonal shifts in obesity might explain this relationship. In a within-subject, repeated-measures design, we investigated sensitivity to a food and a non-food odor in the hungry and sated state in 75 young healthy (26 normal weight, 25 overweight, and 24 obese) participants (37 women). To determine metabolic health status and hormonal reactivity in response to food intake, we assessed pre- and postprandial levels of insulin, leptin, glucose, and ghrelin. Odor sensitivity did not directly depend on body weight status/body mass index (BMI) or hunger state. However, we could establish a strong negative mediating effect of insulin resistance on the relationship between BMI/waist-hip ratio and olfactory sensitivity for the food odor. These findings indicate an impact of metabolic health status on sensitivity to food odors. Our results contribute to a better understanding of the mechanisms behind altered smell perception in obesity.
A Dairy Product to Reconstitute Enriched with Bioactive Nutrients Stops Bone Loss in High-Risk Menopausal Women without Pharmacological Treatment
Authors: Morato-Martínez Marina , López-Plaza Bricia , Santurino Cristina , Palma-Milla Samara , Gómez-Candela Carmen
Published: July 2020

Osteoporosis is a multifactorial disease characterized by the loss of bone mass and deterioration of the internal structure of the bone, increasing the risk of fractures, and is becoming an economic and social problem. The main treatment is pharmacological, however, the population demands other therapies, such as foods with nutrients beneficial to bone health. Seventy-eight healthy menopausal women at risk of osteoporosis or untreated osteopenia were recruited for a randomized, parallel, double-blind clinical trial with two intervention groups: one group consumed a serving a day of the experimental enriched product (experimental group (EG)) and the other group (control group (CG)) consumed the same product without enrichment. The main objective was to compare the effect of consuming a dairy preparation to reconstitute, similar to yogurt when prepared, enriched in calcium, vitamin D, vitamin K, vitamin C, zinc, magnesium, L-leucine and probiotic (Lactobacillus plantarum 3547) on bone metabolism markers for 24 weeks. The EG showed a significantly increased bone mass compared to the CG (0.01 ± 0.03 vs. −0.01 ± 0.03 kg; p < 0.05). In addition, the EG maintained their bone mineral density (BMD) compared to the CG, whose BMD significantly decreased at the end of the study. For biochemical markers, the EG significantly increased the serum levels of the N-terminal propeptide of type I collagen (P1NP) bone formation marker (13.19 ± 25.17 vs. −4.21 ± 15.62 ng/mL; p < 0.05), and decreased the carbo-terminal telopeptide of type I collagen (CTx) bone resorption marker compared to the CG (−0.05 ± 0.19 vs. 0.04 ± 0.14 ng/mL; p < 0.05). On the other hand, the EG exhibited a significantly decreased systolic and diastolic blood pressure compared to the start of the study. Finally, the EG significantly increased their dietary calcium and vitamin D intake compared to the CG. In conclusion, the regular consumption of a dairy product to reconstitute enriched with bioactive nutrients improves bone health markers in menopausal women at risk of osteoporosis without pharmacological treatment.
The Impact of Dietary Glycemic Index and Glycemic Load on Postprandial Lipid Kinetics, Dyslipidemia and Cardiovascular Risk
Authors: Lambadiari Vaia , Korakas Emmanouil , Tsimihodimos Vasilios
Published: July 2020

Many recent studies have acknowledged postprandial hypetriglyceridemia as a distinct risk factor for cardiovascular disease. This dysmetabolic state is the result of the hepatic overproduction of very low-density lipoproteins (VLDLs) and intestinal secretion of chylomicrons (CMs), which leads to highly atherogenic particles and endothelial inflammation. Postprandial lipid metabolism does not only depend on consumed fat but also on the other classes of nutrients that a meal contains. Various mechanisms through which carbohydrates exacerbate lipidemia have been identified, especially for fructose, which stimulates de novo lipogenesis. Glycemic index and glycemic load, despite their intrinsic limitations, have been used as markers of the postprandial glucose and insulin response, and their association with metabolic health and cardiovascular events has been extensively studied with contradictory results. This review aims to discuss the importance and pathogenesis of postprandial hypertriglyceridemia and its association with cardiovascular disease. Then, we describe the mechanisms through which carbohydrates influence lipidemia and, through a brief presentation of the available clinical studies on glycemic index/glycemic load, we discuss the association of these indices with atherogenic dyslipidemia and address possible concerns and implications for everyday practice.
Third-Trimester Glucose Homeostasis in Healthy Women Is Differentially Associated with Human Milk Oligosaccharide Composition at 2 Months Postpartum by Secretor Phenotype
Authors: Saben Jessica L. , Abraham Ann , Bode Lars , Sims Clark R. , Andres Aline
Published: July 2020

Human milk oligosaccharides (HMOs) are bioactive molecules in human milk that play a critical role in infant health. Obesity and associated metabolic aberrations can negatively impact lactation and alter milk composition. Here, the relationship between maternal glucose homeostasis and HMO composition from 136 healthy women was examined. Maternal glucose homeostasis (fasting plasma glucose and insulin, homeostatic model assessment for insulin resistance, and insulin sensitivity index) was evaluated at 30 weeks of gestation in healthy women (body mass index = 18.5–35 kg/m2). Human milk samples were collected at two months postpartum. HMO concentrations were measured via high performance liquid chromatography. Women were categorized into “secretor” and “non-secretor” groups based on 2′-Fucosyllactose concentrations (<100 nmol/mL, non-secretor). Pearson’s correlation analysis and linear models were used to assess the relationships between maternal glucose homeostasis and HMO concentrations. In non-secretors, third trimester fasting plasma glucose and insulin were negatively associated with total HMO-bound sialic acid and concentrations of the sialylated HMOs 3′-sialyllactose and disialylacto-N-tetraose. In secretors, difucosyllactose and lacto-N-fucopentaose-II concentrations increased and sialyllacto-N-tetraose c and sialyllacto-N-tetraose b decreased as insulin sensitivity increased. This study is the first to demonstrate a relationship between obesity-associated maternal factors and HMO composition in both secretor and non-secretor populations.
Recovery of Saccharomyces cerevisiae CNCM I-3856 in Vaginal Samples of Healthy Women after Oral Administration
Authors: Decherf Amelie , Dehay Elodie , Boyer Mickaël , Clément-Ziza Mathieu , Rodriguez Bertrand , Legrain-Raspaud Sophie
Published: July 2020

Bacterial vaginosis and vulvovaginal candidiasis are common causes of impaired health and quality of life for women. Although antimicrobial agents remain the main strategy for the treatment of vaginal infections, their repeated use involves high rates of resistance and recurrence. Alternative approaches such as probiotics are studied. Saccharomyces cerevisiae CNCM I-3856 already demonstrated beneficial effects in experimental models of vaginal infections. This randomized, double-blind, placebo-controlled clinical study was performed to evaluate the recovery of S. cerevisiae CNCM I-3856 in vaginal samples in healthy women after oral consumption. Sixty healthy women were randomized to receive a daily dose of S. cerevisiae CNCM I-3856 or a placebo for 4 weeks. Subcultures and quantitative polymerase chain reaction (qPCR) were used to detect the strain in vaginal and stool samples. A safety assessment was carried out throughout the study. Fifty-seven women completed the study. Over the 4-week supplementation phase, S. cerevisiae CNCM I-3856 has been detected in the vaginal samples of 21% of women (n = 4/19) in the 500 mg Probiotic group and 16% of women (n = 3/19) in the 1000 mg Probiotic group. The strain was detected in the faeces of 90% of women consuming the probiotic. This is the first clinical study demonstrating the migration of yeast from intestine to vagina where it may exert its benefits.
Salt Reduction Strategies in Portuguese School Meals, from Pre-School to Secondary Education—The Eat Mediterranean Program
Authors: Rito Ana Isabel , Mendes Sofia , Santos Mariana , Goiana-da-Silva Francisco , Cappuccio Francesco Paolo , Whiting Stephen , Dinis Ana , Rascôa Carla , Castanheira Isabel , Darzi Ara , Breda João
Published: July 2020

High sodium (salt) consumption is associated with an increased risk of developing non-communicable diseases. However, in most European countries, Portugal included, sodium intake is still high. This study aimed to assess the sodium content of school meals before and after the Eat Mediterranean (EM) intervention—a community-based program to identify and correct nutritional deviations through the implementation of new school menus and through schools’ food handlers training. EM (2015–2017) was developed in 25 schools (pre to secondary education) of two Portuguese Municipalities, reaching students aged 3–21 years old. Samples of the complete meals (soup + main course + bread) from all schools were collected, and nutritional quality and laboratory analysis were performed to determine their nutritional composition, including sodium content. Overall, there was a significant decrease (−23%) in the mean sodium content of the complete school meals, which was mainly achieved by the significant reduction of 34% of sodium content per serving portion of soup. In conclusion, EM had a positive effect on the improvement of the school meals’ sodium content, among the participant schools. Furthermore, school setting might be ideal for nutrition literacy interventions among children, for flavors shaping, and for educating towards less salty food acceptance.
Piperazine- and Piperidine-Containing Thiazolo[5,4-d]pyrimidine Derivatives as New Potent and Selective Adenosine A2A Receptor Inverse Agonists
Authors: Varano Flavia , Catarzi Daniela , Vigiani Erica , Vincenzi Fabrizio , Pasquini Silvia , Varani Katia , Colotta Vittoria
Published: July 2020

The therapeutic use of A2A adenosine receptor (AR) antagonists for the treatment of neurodegenerative disorders, such as Parkinson and Alzheimer diseases, is a very promising approach. Moreover, the potential therapeutic role of A2A AR antagonists to avoid both immunoescaping of tumor cells and tumor development is well documented. Herein, we report on the synthesis and biological evaluation of a new set of piperazine- and piperidine- containing 7-amino-2-(furan-2-yl)thiazolo[5,4-d]pyrimidine derivatives designed as human A2A AR antagonists/inverse agonists. Binding and potency data indicated that a good number of potent and selective hA2A AR inverse agonists were found. Amongst them, the 2-(furan-2-yl)-N5-(2-(4-phenylpiperazin-1-yl)ethyl)thiazolo[5,4-d]pyrimidine-5,7-diamine 11 exhibited the highest A2A AR binding affinity (Ki = 8.62 nM) as well as inverse agonist potency (IC50 = 7.42 nM). In addition, bioinformatics prediction using the web tool SwissADME revealed that 8, 11, and 19 possessed good drug-likeness profiles.
Antioxidant and Antibacterial Properties of Carbosilane Dendrimers Functionalized with Polyphenolic Moieties
Authors: Sanz del Olmo Natalia , Peña González Cornelia E. , Rojas Jose Daniel , Gómez Rafael , Ortega Paula , Escarpa Alberto , de la Mata Francisco Javier
Published: July 2020

A new family of polyphenolic carbosilane dendrimers functionalized with ferulic, caffeic, and gallic acids has been obtained through a straightforward amidation reaction. Their antioxidant activity has been studied by different techniques such as DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical scavenging assay, FRAP assay (ferric reducing antioxidant power), and cyclic voltammetry. The antioxidant analysis showed that polyphenolic dendrimers exhibited higher activities than free polyphenols in all cases. The first-generation dendrimer decorated with gallic acid stood out as the best antioxidant compound, displaying a correlation between the number of hydroxyl groups in the polyphenol structure and the antioxidant activity of the compounds. Moreover, the antibacterial capacity of these new systems has been screened against Gram-positive (+) and Gram-negative (−) bacteria, and we observed that polyphenolic dendrimers functionalized with caffeic and gallic acids were capable of decreasing bacterial growth. In contrast, ferulic carbosilane dendrimers and free polyphenols showed no effect, establishing a correlation between antioxidant activity and antibacterial capacity. Finally, a viability assay in human skin fibroblasts cells (HFF-1) allowed for corroborating the nontoxicity of the polyphenolic dendrimers at their active antibacterial concentration.
A Study of the Mechanical Properties of Composite Materials with a Dammar-Based Hybrid Matrix and Two Types of Flax Fabric Reinforcement
Authors: Bolcu Dumitru , Stănescu Marius Marinel
Published: July 2020

The need to protect the environment has generated, in the past decade, a competition at the producers’ level to use, as much as possible, natural materials, which are biodegradable and compostable. This trend and the composite materials have undergone a spectacular development of the natural components. Starting from these tendencies we have made and studied from the point of view of mechanical and chemical properties composite materials with three types of hybrid matrix based on the Dammar natural hybrid resin and two types of reinforcers made of flax fabric. We have researched the mechanical properties of these composite materials based on their tensile strength and vibration behavior, respectively. We have determined the characteristic curves, elasticity modulus, tensile strength, elongation at break, specific frequency and damping factor. Using SEM (Scanning Electron Microscopy) analysis we have obtained images of the breaking area for each sample that underwent a tensile test and, by applying FTIR (Fourier Transform Infrared Spectroscopy) and EDS (Energy Dispersive Spectroscopy) analyzes, we have determined the spectrum bands and the chemical composition diagram of the samples taken from the hybrid resins used as a matrix for the composite materials under study. Based on the results, we have suggested that these composite materials could be used in different fields of activity.
Double-Layered Microcapsules Significantly Improve the Long-Term Effectiveness of Essential Oil
Authors: Zhang Ting , Luo Yu , Wang Mingxing , Chen Feng , Liu Jinkang , Meng Kai , Zhao Huijing
Published: July 2020

In order to improve the long-term effectiveness of essential oil, a double-layered microcapsule was prepared using the inclusion encapsulation method in this study, with β-cyclodextrin as its inner layer and chitosan and sodium alginate as its outer layer. The optimized preparation process was obtained through the response surface method. The morphology, particle size, encapsulation efficiency, thermal stability and sustained release effect of the double-layered microcapsules were characterized. The microcapsules were spherical, with a particle size distribution between 2–6 μm, and had good thermal stability within 250 °C. Their encapsulation efficiency can be up to 80%, and it can continuously release the active ingredients of the essential oil under normal temperature and high temperature conditions for a long time. In order to further examine the application effect of the double-layered microcapsule, it was loaded onto the cotton fabric by the soak-roll method. The finished cotton fabric showed excellent washability and rubbing fastness. They can still maintain a light fragrance naturally for two months. The microcapsules prepared in this study can be potentially applied in sleep aid, antibacterial, mosquito prevention, food science and other related products.
Evaluation of Osmotic Dehydration Process in Plant Tissue with Low-Field Magnetic Resonance Imaging Enhanced with Paramagnetic Ions
Authors: Suchanek Mateusz , Olejniczak Zbigniew
Published: July 2020

A novel, non-invasive low-field Magnetic Resonance Imaging (MRI) technique for studying the osmotic dehydration process in fruits and vegetables is proposed. A saturated solution of paramagnetic salt is used as both the osmotic substance and the contrast agent for MRI. Using courgette as an example, it is demonstrated that the results obtained by the new method are consistent with the standard mass transport analysis, but additional information about the spatial distribution of osmotic substance within the sample and its evolution in time is provided. The MRI method is much more efficient in terms of experiment time and the amount of biological material needed. Possible extensions of the technique to improve its accuracy are discussed.
Impact of Dual Substrate Limitation on Biodenitrification Modeling in Porous Media
Authors: Abaali Mostafa , Harmand Jérôme , Mghazli Zoubida
Published: July 2020

In this work, we consider a model of the biodenitrification process taking place in a spatially-distributed bioreactor, and we take into account the limitation of the kinetics by both the carbon source and the oxidized nitrogen. This model concerns a single type of bacteria growing on nitrate, which splits into adherent bacteria or free bacteria in the liquid, taking all interactions into account. The system obtained consists of four diffusion-convection-reaction equations for which we show the existence and uniqueness of a global solution. The system is approximated by a standard finite element method that satisfies an optimal a priori error estimate. We compare the results obtained for three forms of the growth function: single substrate limiting, “multiplicative” form, and “minimum” form. We highlight the limitation of the ‘ single substrate limiting model”, where the dependency of the bacterial growth on the nitrate is neglected, and find that the “minimum” model gives numerical results closer to the experimental results.
The Wall: The Earth in True Natural Color from Real-Time Geostationary Satellite Imagery
Authors: Gonzalez Louis , Yamamoto Hirokazu
Published: July 2020

We present “The Wall”, the first web-based platform that animates the Earth in true natural color and close to real-time. The living planet is displayed both during day and night with a pixel resolution of approximately 1 km and a time frequency of 10 min. The automatic processing chains use the synchronized measurements provided by three geostationary satellites: the METEOSAT Second Generation (MSG2), Himawari-8, and GOES-16. A Rayleigh scattering correction is applied, and a cloud of artificial neural networks, chosen to render “true natural color” RBG composites, is used to recreate the missing daytime bands in the visible spectrum. The reconstruction methodology is validated by means of the TERRA/AQUA “Moderate Resolution Imaging Spectroradiometer” (MODIS) instrument reflectance values. “The Wall” is a dynamic broadcasting platform from which the scientific community and the public can trace local and Earth-wide phenomena and assess their impact on the globe.
Using UAV-Based SOPC Derived LAI and SAFY Model for Biomass and Yield Estimation of Winter Wheat
Authors: Song Yang , Wang Jinfei , Shang Jiali , Liao Chunhua
Published: July 2020

Knowledge of sub-field yield potential is critical for guiding precision farming. The recently developed simulated observation of point cloud (SOPC) method can generate high spatial resolution winter wheat effective leaf area index (SOPC-LAIe) maps from the unmanned aerial vehicle (UAV)-based point cloud data without ground-based measurements. In this study, the SOPC-LAIe maps, for the first time, were applied to the simple algorithm for yield estimation (SAFY) to generate the sub-field biomass and yield maps. First, the dry aboveground biomass (DAM) measurements were used to determine the crop cultivar-specific parameters and simulated green leaf area index (LAI) in the SAFY model. Then, the SOPC-LAIe maps were converted to green LAI using a normalization approach. Finally, the multiple SOPC-LAIe maps were applied to the SAFY model to generate the final DAM and yield maps. The root mean square error (RMSE) between the estimated and measured yield is 88 g/m2, and the relative root mean squire error (RRMSE) is 15.2%. The pixel-based DAM and yield map generated in this study revealed clearly the within-field yield variation. This framework using the UAV-based SOPC-LAIe maps and SAFY model could be a simple and low-cost alternative for final yield estimation at the sub-field scale.
Carbon Stocks and Fluxes in Kenyan Forests and Wooded Grasslands Derived from Earth Observation and Model-Data Fusion
Authors: Rodríguez-Veiga Pedro , Carreiras Joao , Smallman Thomas , Exbrayat Jean-François , Ndambiri Jamleck , Mutwiri Faith , Nyasaka Divinah , Quegan Shaun , Williams Mathew , Balzter Heiko
Published: July 2020

The characterization of carbon stocks and dynamics at the national level is critical for countries engaging in climate change mitigation and adaptation strategies. However, several tropical countries, including Kenya, lack the essential information typically provided by a complete national forest inventory. Here we present the most detailed and rigorous national-scale assessment of aboveground woody biomass carbon stocks and dynamics for Kenya to date. A non-parametric random forest algorithm was trained to retrieve aboveground woody biomass carbon (AGBC) for the year 2014 ± 1 and forest disturbances for the 2014–2017 period using in situ forest inventory plot data and satellite Earth Observation (EO) data. The ecosystem carbon cycling of Kenya’s forests and wooded grassland were assessed using a model-data fusion framework, CARDAMOM, constrained by the woody biomass datasets from this study as well as time series information on leaf area, fire events and soil organic carbon. Our EO-derived AGBC stocks were estimated as 140 Mt C for forests and 199 Mt C for wooded grasslands. The total AGBC loss during the study period was estimated as 1.89 Mt C with a dispersion below 1%. The CARDAMOM analysis estimated woody productivity to be three times larger in forests (mean = 1.9 t C ha−1 yr−1) than wooded grasslands (0.6 t C ha−1 yr−1), and the mean residence time of woody C in forests (16 years) to be greater than in wooded grasslands (10 years). This study stresses the importance of carbon sequestration by forests in the international climate mitigation efforts under the Paris Agreement, but emphasizes the need to include non-forest ecosystems such as wooded grasslands in international greenhouse gas accounting frameworks.
Iterative Pose Refinement for Object Pose Estimation Based on RGBD Data
Authors: Huang Shao-Kang , Hsu Chen-Chien , Wang Wei-Yen , Lin Cheng-Hung
Published: July 2020

Accurate estimation of 3D object pose is highly desirable in a wide range of applications, such as robotics and augmented reality. Although significant advancement has been made for pose estimation, there is room for further improvement. Recent pose estimation systems utilize an iterative refinement process to revise the predicted pose to obtain a better final output. However, such refinement process only takes account of geometric features for pose revision during the iteration. Motivated by this approach, this paper designs a novel iterative refinement process that deals with both color and geometric features for object pose refinement. Experiments show that the proposed method is able to reach 94.74% and 93.2% in ADD(-S) metric with only 2 iterations, outperforming the state-of-the-art methods on the LINEMOD and YCB-Video datasets, respectively.
An Energy Efficient Routing Approach for IoT Enabled Underwater WSNs in Smart Cities
Authors: Usman Nighat , Alfandi Omar , Usman Saeeda , Khattak Asad Masood , Awais Muhammad , Hayat Bashir , Sajid Ahthasham
Published: July 2020

Nowadays, there is a growing trend in smart cities. Therefore, Terrestrial and Internet of Things (IoT) enabled Underwater Wireless Sensor Networks (TWSNs and IoT-UWSNs) are mostly used for observing and communicating via smart technologies. For the sake of collecting the desired information from the underwater environment, multiple acoustic sensors are deployed with limited resources, such as memory, battery, processing power, transmission range, etc. The replacement of resources for a particular node is not feasible due to the harsh underwater environment. Thus, the resources held by the node needs to be used efficiently to improve the lifetime of a network. In this paper, to support smart city vision, a terrestrial based “Away Cluster Head with Adaptive Clustering Habit” (ACH) 2 is examined in the specified three dimensional (3-D) region inside the water. Three different cases are considered, which are: single sink at the water surface, multiple sinks at water surface,, and sinks at both water surface and inside water. “Underwater (ACH) 2 ” (U-(ACH) 2 ) is evaluated in each case. We have used depth in our proposed U-(ACH) 2 to examine the performance of (ACH) 2 in the ocean environment. Moreover, a comparative analysis is performed with state of the art routing protocols, including: Depth-based Routing (DBR) and Energy Efficient Depth-based Routing (EEDBR) protocol. Among all of the scenarios followed by case 1 and case 3, the number of packets sent and received at sink node are maximum using DEEC-(ACH) 2 protocol. The packets drop ratio using TEEN-(ACH) 2 protocol is less when compared to other algorithms in all scenarios. Whereas, for dead nodes DEEC-(ACH) 2 , LEACH-(ACH) 2 , and SEP-(ACH) 2 protocols’ performance is different for every considered scenario. The simulation results shows that the proposed protocols outperform the existing ones.
LoRa Traffic Generator Based on Software Defined Radio Technology for LoRa Modulation Orthogonality Analysis: Empirical and Experimental Evaluation
Authors: Lavric Alexandru , Petrariu Adrian I. , Coca Eugen , Popa Valentin
Published: July 2020

The digital revolution has changed the way we implement and use connected devices and systems by offering Internet communication capabilities to simple objects around us. The growth of information technologies, together with the concept of the Internet of Things (IoT), exponentially amplified the connectivity capabilities of devices. Up to this moment, the Long Range (LoRa) communication technology has been regarded as the perfect candidate, created to solve the issues of the IoT concept, such as scalability and the possibility of integrating a large number of sensors. The goal of this paper is to present an analysis of the communication collisions that occur through the evaluation of performance level in various scenarios for the LoRa technology. The first part addresses an empirical evaluation and the second part presents the development and validation of a LoRa traffic generator. The findings suggest that even if the packet payload increases, the communication resistance to interferences is not drastically affected, as one may expect. These results are analyzed by using a novel Software Defined Radio (SDR) technology LoRa traffic generator, that ensures a high-performance level in terms of generating a large LoRa traffic volume. Despite the use of orthogonal variable spreading factor technique, within the same communication channel, the collisions between LoRa packets may dramatically decrease the communication performance level.
Extended Kalman Filter (EKF) Design for Vehicle Position Tracking Using Reliability Function of Radar and Lidar
Authors: Kim Taeklim , Park Tae-Hyoung
Published: July 2020

Detection and distance measurement using sensors is not always accurate. Sensor fusion makes up for this shortcoming by reducing inaccuracies. This study, therefore, proposes an extended Kalman filter (EKF) that reflects the distance characteristics of lidar and radar sensors. The sensor characteristics of the lidar and radar over distance were analyzed, and a reliability function was designed to extend the Kalman filter to reflect distance characteristics. The accuracy of position estimation was improved by identifying the sensor errors according to distance. Experiments were conducted using real vehicles, and a comparative experiment was done combining sensor fusion using a fuzzy, adaptive measure noise and Kalman filter. Experimental results showed that the study’s method produced accurate distance estimations.
Organizational Silos: A Scoping Review Informed by a Behavioral Perspective on Systems and Networks
Authors: Bento Fabio , Tagliabue Marco , Lorenzo Flora
Published: July 2020

In recent years, several organizations have implemented interventions aimed at integrating work processes and bridging network clusters. These are often permeated by different assumptions regarding clusters in organizational settings. There are concerns about the formation of silos and structural barriers to communication across the formal and informal network structures. Conversely, network clusters are regarded as spaces of local social reinforcement from which innovation ideas may emerge. Although terminologically and functionally different, they share some common features insofar as organizational behavior is concerned and the production of artifacts that fulfill organizational goals. The present scoping review presents an analysis of the literature on organizational silos while investigating attempts to bridge network clusters. Based on the search results, 40 studies were included in the analysis of the findings; of these, 20 were empirical studies and were included in a further quantitative analysis of methods and findings. We identified patterns of definitions of silos and variation in terms of aims, variables, and methods used to evaluate interventions among the heterogeneous studies. Special attention was dedicated to the role of consequences of siloed organizational behavior. We conclude that silos comprise barriers to achieving organizational goals insofar as they pose a threat to internal cooperation.
Protective and Risk Factors for Adolescent Substance Use in Spain: Self-Esteem and Other Indicators of Personal Well-Being and Ill-Being
Authors: Fuentes María C. , Garcia Oscar F. , Garcia Fernando
Published: July 2020

Although self-esteem has traditionally been considered as an important correlate of psychosocial adjustment, some empirical studies have found a positive relationship between some domains of self-esteem and drug use among adolescents. The present study analyzes self-esteem and other adjustment personal indicators as protective or risk factors for substance use. Participants were 644 Spanish adolescents aged 12–17 years. Substance use (cigarettes, alcohol, marijuana, and other illicit drugs), multidimensional self-esteem (academic, social, emotional, family, and physical), and other indicators of adolescents’ well-being and ill-being (psychological problems, behavior problems, and parenting) were measured. We observed, on the one hand, that substance use had a significant negative relationship with academic, family, and physical self-esteem. On the other hand, we also observed a significant positive relationship between drug use and social self-esteem. However, this significant relationship disappeared after statistically controlling for sex and age, using both partial correlation analyses and covariance analysis. Interestingly, beyond the importance of each factor related to drugs, prevention science should first of all be able to identify whether the main psychological variables (e.g., social or physical self-esteem) are risk or protective factors for drug use.
Green Cities and Waste Management: The Restaurant Industry
Authors: Tehrani Minoo , Fulton Lawrence , Schmutz Bryan
Published: July 2020

“Green Cities” are cities with the ultimate goal of achieving a net zero-carbon footprint in energy, transportation, architecture, and the activity cost chain of businesses. These cities define the future of our planet by emphasizing the efficient use of resources and the well-being of communities. This study focuses on “Green Cities” and the restaurant industry. It examines the beliefs of restaurant owners/managers on the positive impact of sustainability practices on financial situation, reputation, and attraction of customers, and the relationship between such beliefs and the extent of engagement in sustainability practices. The research also explores whether declaring a city “Green” enhances the sustainability practices in that city. The results indicate that the restaurant owners/managers in all three studied cities strongly believe that sustainability practices enhance the financial performance, reputation of the restaurant, and attraction of customers, yet a significant percentage of the wastes and by-products of the operations of the studied restaurants are discarded. In addition, the results of the study show no significant impact on sustainability practices in the studied restaurants for the declared “Green” cities of Providence (U.S.) and Nancy (France) versus the city of Springfield (U.S.). The study concludes by highlighting the potential reasons underlying the lack of sustainability practices in the restaurant industry and proposes recommendations that can enhance such practices in this industry.
Relaxing Effect Induced by Forest Sound in Patients with Gambling Disorder
Authors: Ochiai Hiroko , Song Chorong , Jo Hyunju , Oishi Masayuki , Imai Michiko , Miyazaki Yoshifumi
Published: July 2020

The number of people addicted to gambling has increased worldwide. They often suffer from debilitating medical conditions associated with stress or depression. This study examined the physiological and psychological reactions of gambling disorder (GD) patients while listening to high-definition forest or city sounds using headphones. In total, 12 Japanese male GD patients were exposed to high-definition forest or city sound waves for 1 min via headphones. Near-infrared spectroscopy of the prefrontal cortex was used to examine oxyhemoglobin (oxy-Hb) concentrations. Heart rate and heart rate variability are indicators of autonomic nervous function. We performed subjective evaluation via the modified version of the semantic differential (SD) method with the profiles of the mood states (POMS). Experiencing forest sounds led to substantial differences as opposed to listening to city sounds: (1) oxy-Hb levels of the bilateral prefrontal cortices were lower (2) the modified SD method resulted in increased comfortable and relaxed feelings, (3) the negative POMS subscale scores were significantly lower, indicating that negative emotions diminished markedly when patients listened to forest sounds. This is the first study to show that sounds of forest relaxed individuals physiologically and psychologically to minimize GD.
Impact of Trade-In Remanufacturing Policy and Consumer Behavior on Remanufacturer Decisions
Authors: Wang Zhen , Duan Yongrui , Huo Jiazhen
Published: July 2020

To develop more competitive strategies for different types of remanufacturing companies under the trade-in remanufacturing policy, this paper investigates the impact of the trade-in remanufacturing policy and consumer choice behavior on decisions of a traditional brand remanufacturer and a third-party brand remanufacturer by using a consumer utility model. The results suggest that the trade-in remanufacturing policy increases demand for the third-party brand, but does not increase demand for the traditional brand. Further, although trade-in remanufacturing policy increases both brand prices, it also increases consumer surplus and corporate profits. Neither the traditional brand remanufacturer nor the third-party brand remanufacturer can completely monopolize the remanufacturing market. In this situation, the traditional brand remanufacturer should strive to increase consumer loyalty, and the third-party brand remanufacturer should strive for consumer recognition of third-party remanufactured products.
Selection of Novel Geopolymeric Mortars for Sustainable Construction Applications Using Fuzzy Topsis Approach
Authors: Saeli Manfredi , Micale Rosa , Seabra Maria Paula , Labrincha João A. , La Scalia Giada
Published: July 2020

Construction is recognized as one of the most polluting and energy consuming industries worldwide, especially in developing countries. Therefore, Research and Development (R&D) of novel manufacturing technologies and green construction materials is becoming extremely compelling. This study aims at evaluating the reuse of various wastes, originated in the Kraft pulp-paper industry, as raw materials in the manufacture of novel geopolymeric (GP) mortars whose properties fundamentally depend on the target application (e.g., insulating panel, partition wall, structural element, furnishing, etc.). Five different wastes were reused as filler: Two typologies of Biomass Fly Ash, calcareous sludge, grits, and dregs. The produced samples were characterized and a multi criteria analysis, able to take into account not only the engineering properties, but also the environmental and economic aspects, has been implemented. The criteria weights were evaluated using the Delphi methodology. The fuzzy Topsis approach has been used to consider the intrinsic uncertainty related to unconventional materials, as the produced GP-mortars. The computational analysis showed that adding the considered industrial wastes as filler is strongly recommended to improve the performance of materials intended for structural applications in construction. The results revealed that the formulations containing 5 wt.% of calcareous sludge, grits, and dregs and the one containing 7.5 wt.% of calcareous sludge, grits, dregs, and Biomass Fly Ash-1 have emerged as the best alternatives. Furthermore, it resulted that the Biomass Fly Ash-2 negatively influences the structural performance and relative rank of the material. Finally, this case study clearly shows that the fuzzy Topsis multi-criteria analysis represents a valuable and easy tool to investigate construction materials (either traditional and unconventional) when an intrinsic uncertainty is related to the measurement of the quantitative and qualitative characteristics.
Correction: Bianca, B.L.; Gheorghe, P.S. Unsupervised Clustering for Hyperspectral Images. Symmetry 2020, 12, 277
Authors: Bianca Bilius Laura , Gheorghe Pentiuc Stefan
Published: July 2020

The authors wish to make the following corrections to their paper [...]