bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of the Jakarta Elderly Card Program in Meeting the Basic Needs of the Elderly
Authors: Rizal* Ahmad , Susilahati Susilahati
Published: May 2023

Research on the Implementation of the Jakarta Elderly Card Program in Fulfilling the Basic Needs of the Elderly is motivated by the increasing number of poor elderly people in the Special Capital Region of Jakarta (DKI) Jakarta, including the number of poor elderly people in the Jagakarsa village. Along with this, the DKI Provincial Government has launched the KLJ Program (Jakarta Elderly Card) as an effort to meet the basic needs of the poor elderly. However, the implementation of this KLJ is often in the spotlight of various parties, because it is assumed to be less useful and not on target. The purpose of this study was to describe how the implementation of the KLJ program in meeting the basic needs of the elderly. The research method uses a qualitative research approach. Data was collected through interviews, observation and documentation. The main theory used is the theory of David C Korten which states that to find out how the implementation of a program can look at the dimensions of the program itself, then the organization of its implementation and the program's goals. The results showed that the implementation of the program could increase the number of poor elderly people. This is because there is a clear concept of this program and there is strong support from the program implementing elements, both the city government and the community. This is what causes the inconsistent implementation of aid distribution. In general, assistance is used to meet the basic needs of the elderly. Recommendations from this research are the need for an official website that is easily accessible to the public and the need for consistent distribution of time.
Implementation of the National Insight Values of Hamengku Buwana IX For Character Education
Authors: Wignjosasono Ken Widyatwati
Published: May 2023

The noble values and national insight of Hamengku Buwana IX, who was nationalist and democratic, played an important role in shaping the character of the younger generation. So that as the next generation of the nation they not only have intellectual intelligence but also have emotional intelligence. This qualitative research with historical approach uses descriptive analysis method to find the noble values and national insight of Hamengku Buwana IX. The results showed that the leadership values and national insight of Hamengku Buwana IX in respecting ancestral culture and prioritizing the interests of the nation and state were the basis for character education and noble character education. Hamengku Buwana IX is able to combine traditional and modern thinking, which refers to noble values and national insight by prioritizing the interests of society and the state in his leadership. So that character education for the younger generation can be directed at emphasizing the noble values and national insight of Hamengku Buwana IX.
The Analysis of Generation Z's Perception in Decisions on Selection of Islamic Banking Service
Authors: Rusli Moch.
Published: May 2023

Islamic Banking as an alternative financial institution for the community and its current condition is growing. Likewise with some sharia products offered began to adjust to the needs of the community. Given that most of Indonesia's population is Muslim, the potential for the development of Islamic banking is also quite large. Islamic banking should be able to develop more broadly to demonstrate sharia values reflected in law, economic, social and political institutions. The Islamic banking system is expected to apply Islamic economic rules to avoid the conventional system to conform to Islamic religious teachings. The development of Islamic banking customers today not only targets the worker segment but also targets generation Z, the majority of whom this year work as students. The current condition of Islamic banking is unknown among generation Z, so it is necessary to analyze what factors influence the selection of Islamic banking as a financial institution to facilitate economic activities. The results of the analysis can be formulated to carry out strategies related to marketing, operations, risk, and finance in carrying out activities. In answering this, research was conducted using quantitative methods using multiple linear regression which aimed to see psychological, cultural, social, personal, and marketing factors in relation to the selection of Islamic banking. The results showed that partially psychological factors, social factors, personal factors and marketing factors had a positive effect on variable Y, namely the selection of Islamic banking services generation Z and factor X represented by cultural factors had a negative influence not significantly.
Representation of Gender Equality in Ngeri Ngeri Sedap Films
Authors: Larasati* Auliya Wahyu , Adiyanto Wiwid
Published: May 2023

Film can be the means in deliver issue social the one the story alone contains the problem of gender equality in it, as is the reality of social life equality gender able create distance position between women and men. This study uses a descriptive qualitative method using semiotic analysis from Charles Sanders Pierce. The paradigm in research is clinking to the critical paradigm. This research focuses on signs that show gender equality both verbally and non- verbally on screen on certain scene in the film Horrified Sedap. Theory representation Stuart Hall if be associated with issue equality gender in the film Horrified Horrified will show the film as a medium of criticism today because it is still numerous because it is influenced by reality and culture. The findings on gender equality research are discussed in order to carry out the plan. 2) gender equality in obtaining employment opportunities. 3) the attitude of resistance, the attitude of resistance by the female character against the male character and the resistance of the male character against the male character. 4) the right to voice opinions and concerns of both women and men. 5) the existence of success that has arisen thanks to the cohesiveness of the business of women and men.
"Fragmentos globales". La inserción de la prensa mexicana en la esfera pública transnacional durante las primeras décadas del siglo veinte
Authors: Serna Rodríguez Ana María
Published: May 2023

Con base en teorías que analizan la globalización y la esfera pública, el artículo analizael flujo de los debates relativos a la Guerra Mundial y la relación de México con EstadosUnidos para comprender las posibilidades de la esfera pública transnacional en unacoyuntura donde chocaron diversas formas de vinculación humana: el nacionalismo, lacultura local y las fuerzas de lo global. Los periódicos que proliferaron en México en lasprimeras décadas del siglo veinte propagaron información y opiniones que conectabanla circunstancia local con el mundo. El desempeño de esta función que surgió de necesidadesy preocupaciones locales estuvo inmersa en una dinámica global y fue conscientede su pertenencia a ese todo. El potencial explosivo de estos focos de opinión llamó laatención en foros internacionales. Funcionaron como centros nodales de la acción comunicativade una esfera pública fragmentada pero transnacional.
Palabras clave: esfera pública, globalización, regionalismo, nacionalismo, periodismo
Internal and external factors related to the Return On Equity (ROE) of Ecuadorian Savings and Credit Cooperatives, Segment 1, Period 2014 – 2020
Authors: Quintanilla Gavilanes Aníbal , Quintanilla Castellanos Jennifer Del Pilar , Chan Paredes Tatiana Fedayina , Chagerben Werner
Published: May 2023

Savings and Credit Cooperatives in Ecuador play a very important role in the socioeconomic development of communities, productive associations and other niches that are not financially served by traditional private banks, both national and foreign. In fact, the financial inclusion of productive and consumer units in the rural sector - above all - depends on the economic and financial sustainability of these entities. In this context, it is important to know how profitable cooperatives are in Ecuador, identifying those factors, internal and external, that explain such profitability; for this reason, this article aims to analyze the relationship between internal factors such as liquidity, management and solvency indicators; and external factors such as inflation and real GDP with the profitability of cooperatives, segment I, measured through the Return On Equity (ROE). Using econometric techniques, it is found that the country's production level and the generalized price level as external factors, maintain a statistically significant relationship with respect to the ROE of the cooperatives.
Creolized text as an object of study in linguistics
Authors: Pishcherskaia Elena Nikolaevna
Published: May 2023

Linguistics as a science is constantly developing and expanding its boundaries, including in its competence all new objects of research. One of such objects is a creolized text, which is a special kind of communicative phenomenon consisting of signs of different semiotic systems. Creolized text is actively used in various spheres of public life, including advertising, media, art, education, etc. The article is devoted to the creolized text as an object of study in linguistics. The object of research in this article is a creolized text. The purpose of this article is to consider the creolized text as an object of study in linguistics through the analysis of published studies. The methodological basis and material of the study were the classical works of domestic and foreign scientists on the problems of text theory, paralinguistics, semiotics, communicative linguistics and linguoculturology, as well as recent studies, the object of study of which were creolized or polycode texts. The author defines the concept of a creolized text, highlights the specific characteristics of a creolized text compared to a single-code text, describes the main scientific approaches to the analysis of a creolized text and research methods. The article presents an overview of classical scientific works devoted to the analysis of creolized text, as well as studies published in recent years. The author concludes that the creolized text is a complex and multifaceted object of study in linguistics, which reflects the trends in the development of modern society and culture and allows expanding the boundaries of linguistic knowledge and understanding of language as a means of communication.
Leukemia Cutis as the Presenting Sign of Acute Myeloid Leukemia in an HIV+ patient
Authors: Garcia Natalie , Mcrae Charlotte , Smith Abigail , Graham Lauren
Published: May 2023

Leukemia Cutis (LC) is a rare extramedullary cutaneous manifestation of leukemia that varies in terms of clinical presentation, leukemia type, and timing of presentation in relation to systemic leukemia. LC typically presents following diagnosis of systemic leukemia and during an active flare or relapse. An estimated 3.7% of patients with Acute Myeloid Leukemia (AML) develop LC. A 61-year-old male with poorly controlled HIV presented with a rash that began one month prior on his cheek as a red papule, which he believed was an ingrown hair. On exam, pink and yellow firm papules and nodules covered his entire body surface except the groin and axilla. One nodule held a peau d’orange appearance. The rash was overall asymptomatic, and he reported only increased fatigue. His CD4 count and viral load were 136 and 330,000 respectively. One punch biopsy revealed negative cultures for fungus, bacteria, and acid-fast bacilli. Two biopsies sent for pathologic evaluation revealed AML of the skin. Bone marrow biopsy confirmed AML. Clinically the presentation of LC is nonspecific, and systemic symptoms rarely appear in conjunction with LC. High clinical suspicion and histopathologic examination are necessary for diagnosis of LC.
Cutaneous Prostate Adenocarcinoma Masquerading as Cellulitis
Authors: Darnall Ariel , Olsen Rebecca , Hamann Dathan , Estrada Sarah
Published: May 2023

Cutaneous metastases of prostate cancer are a rare entity and mimic many other common cutaneous conditions such as cellulitis, zosteriform lesions, and many others, making it easy to misdiagnose. Recognition of this condition is vital to prevent delays in treatment, as lesions usually appear in late stages of the disease and are associated with a high fatality rate. Here we describe a case of a 64-year-old man with a history of diffuse metastatic prostate carcinoma, who presented with a suprapubic rash that was initially diagnosed as cellulitis but was later determined to be cutaneous metastasis. Clinical characteristics of this metastasis and common dermal lesions with similar clinical presentations are discussed. Clinicians should be aware of the characteristics of this cutaneous metastasis and consider it when evaluating skin lesions that mimic soft tissue infections.
Bazex Syndrome Associated with Angioimmunoblastic T-cell Lymphoma
Authors: Ugoh Gregory Ugoh , Linfante Anthony , Good Allison , Wilson Janice , Kroger Kathleen
Published: May 2023

Bazex syndrome, also known as Acrokeratosis paraneoplastica, is a paraneoplastic disorder characterized by erythematous psoriasiform plaques involving the nose, ears, and acral sites. Although classically associated with squamous cell carcinomas of the upper aerodigestive tract, it has also been reported in association with adenocarcinoma, genitourinary tumors, multiple myeloma, and rarely, peripheral T-cell lymphoma and follicular lymphoma in-situ. Herein, we present a patient with Bazex syndrome associated with angioimmunoblastic T-cell lymphoma (AITL), a rare association not previously reported in the literature.
Blastomycosis-Like Pyoderma in a 59-year-old Male with Type 2 Diabetes Mellitus
Authors: Salusti-Simpson Michela , Porter Hannah , Taylor Dustin , Piette Evan
Published: May 2023

Blastomycosis-like pyoderma (BLP) is a rare cutaneous disorder that results from an exaggerated response to a bacterial infection, most commonly Staphylococcus aureus. There are a variety of reported predisposing factors, including diabetes, obesity, leukemia, primary immunodeficiency, and immunomodulatory therapy. Clinical and histopathological findings of BLP can be quite disparate, often resulting in a delay in diagnosis. We report here a case of a man who presented with an enlarging verrucous nodule of his neck, and was subsequently diagnosed with BLP. The purpose of sharing this case is to contribute to the existing literature of this rare disease by highlighting a unique presentation.
Eruptive Keratoacanthoma in a 59-year-old Female with Chronic Kidney Disease: A Case Report and Review of Treatment Approaches
Authors: Taylor Mitchell , Pham Amelia , Clausen Michaela , Darabi Kamruz
Published: May 2023

We present the case of a 59-year-old female with multiple squamous neoplasms, including keratoacanthomas, well-differentiated squamous cell carcinomas, and prurigo nodules. The patient developed dozens of lesions progressively over the course of a few years. Keratoacanthomas can be challenging to distinguish from well-differentiated squamous cell carcinomas; this and the presence of numerous lesions poses a major challenge with diagnosing and managing this condition. The pathogenesis, challenges with diagnosis and management, and treatment regimens for eruptive keratoacanthomas are further discussed.
Melasma is Associated with Lower Serum Vitamin D Concentrations as Compared to Healthy Controls
Authors: Shope Chelsea , Andrews Laura , DeVore Ansley , Wine Lee Lara , Wagner Carol
Published: May 2023

Background
Melasma is a common, chronic skin condition of hyperpigmentation involving the appearance of symmetric and irregular light brown macules and patches, mainly on sun exposed skin of the head and neck. Though the pathogenesis is not fully understood, hyperfunctional melanocytes are known to deposit excess melanin in the epidermis and dermis. Known risk factors or triggers include genetic influence, hormonal influence, and ultraviolet radiation. Due to the avoidance of ultraviolet light, vitamin D supplementation is recommended. Due to known influence of vitamin D on the skin and the large prevalence of melasma in the public, the association between vitamin D and melasma will be examined further.
Methods
A retrospective review was performed utilizing the TriNetX platform to query de-identified patient data from the Medical University of South Carolina’s Electronic Health Record system over a 9-year period from January 2013 to May 2022. Calcidiol (25-hydroxy-vitaminD) was utilized as a surrogate for Vitamin D level. Statistical analyses were performed using Chi-square tests.
Results
Of 1,962 patients diagnosed with melasma, 840 had a serum calcidiol level measured following diagnosis. The majority of these patients were female (77%) and had an average age of 60.3 + 19.2 years. Melasma patients were most commonly Caucasian (81%), followed by African American (15%) and Hispanic or Latino (3%). Patients with melasma had an average serum calcidiol of 33.8 + 15.8 ng/mL (reference range: 25 – 80 ng/mL). This was significantly lower than comparison to 2,146 dermatology patients not diagnosed with melasma (36.8 + 15.8 ng/mL, p-value <0.0001%).  
Conclusion
Vitamin D has been demonstrated to be critical in the skin, including differentiation and proliferation of melanocytes. Our results suggest that patients with melasma, who have significantly lower levels of serum vitamin D than their healthy counterparts, may benefit from vitamin D supplementation. Future studies investigating improvement in melasma symptoms following vitamin D supplementation are needed.
Dermatological Findings in Children’s Films
Authors: Momin Fareen , Reese Vail , Wagner Jr. Richard F.
Published: May 2023

Introduction: Filmmakers use dermatologic findings to help the audiences decipher between ‘good’ and ‘bad’ characters by portraying villains with recognizable skin findings. The objective of this study was to analyze 18 Disney live-action movies in relation to their earlier animated releases to determine whether there were changes or correlation about how the industry portrayed certain characters based on their roles as heroes or villains.
Methods: To better understand how the use of dermatological findings are changing in the film industry, eighteen Disney live-action movies in relation to their earlier animated releases were compared for changes or correlation on how the industry portrays certain characters based on their roles as heroes or villains.
Results: Film antagonists were depicted with significantly more dermatologic findings than protagonists (p<0.0001). In addition, the frequency of periorbital hyperpigmentation (p=0.02) and nasolabial folds (p=0.05) were significantly higher in antagonists verses protagonists.
Conclusion: These findings have important implications about the dermatological content of movies directed toward children. Findings of this study suggest filmmakers are continuing to use common dermatological findings to indirectly portray characters as ‘good’ or ‘bad.’
Five Years Later: Continuing Disparity in the Geographic Density and Distribution of U.S. Dermatologists
Authors: Nguyen Christopher , Nguyen Quoc-Bao , Lauck Kyle , Hebert Adelaide
Published: May 2023

Objectives: A discrepancy exists in the geographical distribution of dermatologists across the United States (US). The aim of this study was to reexamine the current geographical density of dermatologists to describe any changes compared to date from 5 and 12 years ago.

Methods: Membership data from the 2021 American Academy of Dermatology (AAD) database were retrieved to characterize the distribution of dermatologists in 3-digit zip code areas.

Results: Out of 712 populated zip codes with dermatologists, 510 (71.6%) had less than 4 dermatologists per 100,000, as compared to 515 (72.3%) in 2016 (– 0.19% CAGR). The dermatologist density of the 100 most populated areas (M = 4.5 dermatologists per 100,000, SD = 3.3) and 100 least populated areas (M = 1.6 dermatologists per 100,000, SD = 6.2) were significantly different (P < 0.0001).

Conclusion: This analysis provides continued trends to compare to previous studies performed in 2016 and 2009. The highest and lowest density areas were similar to results from previous studies. The results indicate an enduring and significant maldistribution of dermatologists in the US.
Acne symptoms and impact of acne on social functioning, emotional functioning, and activities of daily living (ADL) among patients with moderate to severe non-nodular Acne Vulgaris (AV) in community practices across the U.S
Authors: Graber Emmy , Baldwin Hilary , Alexis Andrew F. , Del Rosso James , Fried Richard G. , Harper Julie C. , Hebert Adelaide , Kircik Leon , Rieder Evan A. , Stein Gold Linda , Narayanan Siva , Koscielny Volker , Kasujee Ismail
Published: May 2023

Objective: Evaluate patient self-perceived AV symptoms and impact of AV on emotional/social functioning and ADL, among AV patients in community practices across the U.S. Methods: Single-arm, prospective cohort study (PROSES: NCT04820673) was conducted with moderate-to-severe non-nodular AV patients >9yrs who were prescribed sarecycline in real-world U.S community practices. Validated ASIS questionnaire (with Signs and Impact (emotional & social) domains) and an Expert Panel Questionnaire (EPQ; emotional functioning (items 1-4), social functioning (items 5-7), and ADL (items 8-11)) were completed by patients (>12yrs) and caregivers (for patients 9-11yrs) at baseline and week-12. All items were scored on five-point adjectival response scale (score: 0 (never/not at all) – 4 (all the time/very much/extremely)); a higher ASIS domain score indicate severe symptoms or negative impact of AV. ASIS domain scores and proportion of patients reporting score=2/3/4 (moderate to high burden/impact or parent understanding (EPQ10)) for EPQ items at baseline were analyzed. Results: A total of 253 AV patients completed the study (pediatric: 39.92%; female: 66.40%; moderate AV: 86.56%; severe AV: 13.44%). At baseline, patients reported moderate AV burden in most domains, as depicted by the following domain score: signs: 1.96, impact: 2.06, emotional impact subdomain: 2.43; social impact subdomain: 0.98. From EPQ items, proportion of patients reporting score=2/3/4 (moderate to severe burden) at baseline were: patients’ mood/anger (EPQ1) – 56.13%; worries about AV worsening (EPQ2) – 79.45%; thinking about acne (EPQ3) – 84.19%; level of acne worries (EPQ4) – 72.73; patients’ social media/’selfie’ activity (EPQ5) – 51.38%; impact on real-life plans (EPQ6) – 44.66%; efforts to hide AV (EPQ7) – 72.73%; picked-on/judged due to AV (EPQ8) – 26.88%; ability to reach future goals (EPQ9) – 27.27%; sleep impact (EPQ11) – 27.67%; parent understanding of AV concerns (for patients<18yrs; EPQ10) – 84.16%. Conclusion: Moderate to severe AV burden/impact was observed in this prospective cohort of AV patients in the U.S. Emotional impact and social impact of AV were especially more pronounced among the AV population.
Clinician satisfaction with treatment outcomes among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S in PROSES study: Analysis by concomitant medication use
Authors: Graber Emmy , Baldwin Hilary , Alexis Andrew F. , Del Rosso James , Fried Richard G. , Harper Julie C. , Hebert Adelaide , Kircik Leon , Rieder Evan A. , Stein Gold Linda , Narayanan Siva , Koscielny Volker , Kasujee Ismail
Published: May 2023

Introduction: The objective of this analysis was to evaluate clinician satisfaction with treatment outcomes, stratified by the use of concomitant acne medications, among AV patients administered sarecycline in community practices across the U.S.

Methods: A single-arm, prospective cohort study (PROSES) was conducted with moderate-to-severe non-nodular AV patients >9 years who were prescribed sarecycline in real-world community practices in the US. Clinician satisfaction with sarecycline treatment outcomes was assessed on a five-point adjectival response scale (1 (very dissatisfied)-5 (very satisfied)). Proportion of patients for whom clinicians reported very satisfied/satisfied was analyzed, stratified by the use of any concomitant AV medication during the study (Yes vs. No (monotherapy)).

Results: A total of 253 AV patients completed the study (adults 60.08% (mean age 26.63); pediatric 39.92% (mean age 14.81); female: 66.40%; white/Caucasian: 68.38%, African American: 8.70%; other races: 22.92%). Per IGA at baseline, 86.56% & 13.44% had moderate and severe AV, respectively. Key concomitant treatments for AV observed during the study included: topical retinoids (24.51%), topical antibiotics (13.44%), benzoyl peroxide (5.93%), topical dapsone (5.14%) and other (17.00%; predominantly adapalene/benzoyl peroxide). Half of the patients (49.80%) were on sarecycline monotherapy (i.e., did not use any concomitant treatments for AV).

In the overall study cohort, at week-12, clinicians reported very satisfied/satisfied with sarecycline treatment outcomes for 88.14% of patients. At week-12, clinician satisfaction (very satisfied/satisfied) was 88.98% among patients using concomitant AV medications, and 87.30% among patients using no concomitant AV medications (i.e., on sarecycline monotherapy).

Conclusion: Within the study cohort administered sarecycline, a narrow-spectrum, tetracycline-derived antibiotic, for 12 weeks, overwhelming majority of clinicians were very satisfied/satisfied with sarecycline treatment outcomes at week-12, and clinician satisfaction was similar among patients on sarecycline monotherapy and those on concomitant AV medications.
Impact of Actinic Keratosis on patient-reported AK symptoms, emotions and functioning measured using Skindex-16, among patients with Actinic Keratosis administered tirbanibulin in real-world community practices across the U.S. (PROAK Study)
Authors: Rigel Darrell , Lebwohl Mark , Schlesinger Todd , Armstrong April , Berman Brian , Bhatia Neal , Del Rosso James , Kircik Leon , Patel Vishal A. , Narayanan Siva , Koscielny Volker , Kasujee Ismail
Published: May 2023

Objectives: Actinic Keratosis (AK) has been shown to negatively affect emotional functioning and skin-related quality of life of patients. Impact of tirbanibulin treatment in alleviating AK disease burden in patients with AKs is not adequately understood. Objective of the analysis is to evaluate changes in patient-reported AK symptoms, emotions, and functioning, among patients with AKs treated with tirbanibulin in community practices across the U.S. Methods: A single-arm, prospective cohort study (PROAK) was conducted among adult patients with AKs on the face or scalp who were newly initiated with tirbanibulin treatment in real-world community practices in the U.S, as part of usual care. Patients and clinicians completed surveys and clinical assessments at baseline, week-8 (timeframe for main endpoints) and week-24. Skindex-16, completed at baseline and week-8, is a 16-item survey with 3 domains: symptoms (items 1-4), emotions (items 5-11) and functioning (items 12-16), with each item scored on a seven-point adjectival response scale, with a potential score of 0 (never bothered) to 6 (always bothered). Changes from baseline in proportion of patients reporting a score of 0 or 1 (never or least bothered; i.e., least disease burden) was analyzed for all Skindex-16 items at week-8. Results: A total of 290 patients with AKs completed the study assessments at week-8 (female: 31.38%; history of skin cancer: 61.72%; Fitzpatrick skin type: I: 7.59%, II: 71.38%, III: 18.62%, IV: 1.38%, V: 1.03%). Patient self-reported skin-texture was – dry: 39.66%, smooth: 47.59%, rough: 19.66%, bumpy: 18.62%, scaly: 35.17%, blistering/peeling: 6.55%. Within symptoms domain of Skindex-16 related to itching, burning/stinging, hurting, and irritation, proportion of patients reporting “never or least bothered” increased significantly for each item at week-8 (p<0.0001). Within emotions domain of Skindex-16 related to persistence of condition, worries about skin, appearance, frustration, embarrassment, being annoyed, and feeling depressed, proportion of patients reporting “never or least bothered” increased significantly for each item at week-8 (p<0.0001). Within functioning domain of Skindex-16 related to interactions with others, desire to be with others, show affection, effect on daily activities, and effect on work or enjoyable activities, proportion of patients reporting “never or least bothered” increased significantly for each item at week-8 (p<0.0001). Conclusion: Patients with AKs who used once-daily tirbanibulin treatment for 5-days reported a significant reduction in the AK burden, as indicated by the improvement in AK symptoms and emotional/functional impact, at week-8.
Epidermolysis Bullosa Pruriginosa Treated with Acitretin
Authors: Jain Navnee , Marfatia Yogesh , Jinwala Preksha Panthesh , Patel Hiral
Published: May 2023

Epidermolysis bullosa pruriginosa (EBP) is a rare inherited and distinctive clinical subtype of dystrophic epidermolysis bullosa. Here is a paediatric case of EBP with extremely pruritic lesions on extensor aspect of limbs and back, where the main modality of treatment given was topical retinoid (tazarotene) and oral retinoid (Acitretin), to which she had responded well clinically as well as symptomatically.
Prevotella buccae bacteremia in an immunocompetent host – A case report and review of the literature
Authors: Isaac Sangeetha , Pasha Mohammed Afraz , Isaac Shalom , Tulsidas Haresh
Published: May 2023

Prevotella, a Gram-negative rod, is a normal commensal found on human mucosal surfaces. While infection with Prevotella spp. among immunocompromised individuals is common, among immunocompetent individuals, infection with this species is rare. We report an unusual case of a patient with Prevotella buccae bacteremia and we have conducted a short review of the literature on prior reports of P. buccae bacteremia.
PENERAPAN MANAJEMEN RESIKO LIKUIDITAS PADA BANK SYARIAH
Authors: Adiyes Putra Popi , Agus  , Saparuddin
Published: May 2023

Manajemen resiko likuiditas merupakan pengelolaan bank agar terhindar dari resiko likuiditas yang disebabkan oleh ketidak mampuan bank dalam membayar kewajiban jangka pendeknya. Agar bank terhindar dari resiko likuiditas, maka bank harus memastikan dana yang tersedia cukup untuk membayar kewajiban-kewajiban, mencairkan dana nasabah yang akan jatuh tempo, membiayai kegiatan operasional dan cukup dana menghadapi kemungkinan munculnya ekonomi yang memburuk. Kecukupan dana bank sangat tergantung dari instrumen pengelolaan likuiditas. Instrumen likuiditas bisa diperoleh dari penghimpunan dana pihak ketiga (DPK), peminjaman di pasar uang syariah, pembelian SBI syariah, mencari investor dari dalam negeri atau investor luar negeri, atau dari sumber-sumber dana lainnya. Hasil penelitian memperlihatkan penerapan manajemen resiko likuiditas pada bank syariah dan UUS dilaksanakan dalam bentuk; a) Direksi, komisaris dan DPS melakukan pengawasan aktif terhadap rumusan dan pelaksanaan manajemen resiko, b) Menyusun kebijakan, prosedur, dan penetapan limit manajemen resiko, c) Melakukan proses identifikasi, pengukuran, pemantauan dan pengendalian resiko serta sistem informasi manajemen resiko, d) Membentuk sistem pengendalian intern yang menyeluruh.
Empowering the youth in times of crisis: Analyzing crisis-related activities among the youth of Muntinlupa City, Philippines during typhoons
Authors: Lacerna Rudolf Anthony , Reyes Jerielyn , Ancheta Jeffrey Rosario
Published: May 2023

This study attempts to analyze the crisis-related activities among the youth of Muntinlupa City as the basis for a crisis communication management plan which is imperative to minimize the typhoon's impact. The researchers selected six youth representatives from different parts of Muntinlupa City to participate in the conduct of a focused-group discussion. Several themes have emerged before, during and after the typhoon based on their experiences and perspectives of crisis-related activities in the City. For instance, information dissemination on typhoon preparedness, coordination with different local agencies and behavior change communication strategies are the crisis-related activities before the typhoon. Meanwhile, close monitoring of evacuees with the help of local agencies, roving of barangay emergency response team, distribution of relief goods and hot meals, regular information dissemination, provision of informal learning to children and provision of breastfeeding stations are among the crisis-related activities during the typhoon. On the other hand, the crisis-related activities after the typhoon include assessment of devasted areas giving assistance, seeking psychological help, coordination with the health center and post-typhoon information dissemination. These crisis-related activities are good indicators that the youth involvement and participation in Muntinlupa City are active to ensure the safety of their communities during the disaster.
Landslide hazard zonation using Bivariate Frequency Ratio Method along National highway-1 from Baramulla-Uri Road stretch, North Kashmir Himalayas, India
Authors: Beigh Iftikhar Hussain , Bukhari Kaiser
Published: May 2023

The study focuses on the application of frequency ratio method (FRM) for the creation of landslide hazard map along the National Highway-1(NH-1) road between Baramulla and Uri in North Kashmir Himalaya, India. The landslide hazard zonation (LHZ) map was prepared by integrating all the landslide-inducing factors with frequency ratio values. A database of notable landslides in the study area was integrated with the hazard map for validation. The overall study showed that 22.28% of the study area falls under very high and high hazard zones. Finally, the output map was validated using the 40% landslide validation data. Moreover, ROC curve method was utilized to validate the model which showed the acceptable result of 0.803 AUC value for the landslide hazard map of the study area. Therefore, LHZ map produced by this study can be used to guide planners or engineers in identifying safe zones for carrying out development projects and for future risk assessment studies in the study region.
The Disastrous Effects of Soil Salinity and pH on Environmental Systems
Authors: Shinde Ganesh S. , Sapkale Shivam J. , Sapkale Jagdish B.
Published: May 2023

Soil salinity is a natural element of arid and semi-arid climates and it is becoming a growing concern in the soils across the world. When water-soluble salts build in a soil, it gets salinized. These salts contain chloride, sulphate, carbonate, bicarbonate and sodium in addition to potassium and magnesium. Due to shortage of oxygen, soil with a high salt level becomes incapable of supporting plant and animal life. This review discusses the causes of salinity, its impact on plant growth, their limits/standard in the environment systems and case studies of saline land. Besides this, salinity levels in streams and lands are generally rising as a result of rising groundwater levels. Most of the rural and urban communities have lost productive cropland and water supplies due to natural instability to these environments and human induced interferences. Crop productivity, seed germination soil and water quality are adversely affected by soil salinity. A coastal region is also particularly vulnerable to climate change. There is a need to study soil salinization and its measures in detail for sustainable environmental systems.
3DDPDs: Describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors
Authors: Gorostiola González Marina , van den Broek Remco L. , Braun Thomas G.M. , Chatzopoulou Magdalini , Jespers Willem , IJzerman Adriaan P. , Heitman Laura H. , van Westen Gerard J.P.
Published: May 2023

Proteochemometric (PCM) modelling is a powerful computational drug discovery tool used in bioactivity prediction of potential drug candidates relying on both chemical and protein information. In PCM features are computed to describe small molecules and proteins, which directly impact the quality of the predictive models. State-of-the-art protein descriptors, however, are calculated from the protein sequence and neglect the dynamic nature of proteins. This dynamic nature can be computationally simulated with molecular dynamics (MD). Here, novel 3D dynamic protein descriptors (3DDPDs) were designed to be applied in bioactivity prediction tasks with PCM models. As a test case publicly available G protein-coupled receptor (GPCR) MD data from GPCRmd was used. GPCRs are membrane-bound proteins, which are activated by hormones and neurotransmitters, and constitute an important target family for drug discovery. GPCRs exist in different conformational states that allow transmission of diverse signals and that can be modified by ligand interactions, among other factors. To translate the MD-encoded protein dynamics two types of 3DDPDs were considered: one-hot encoded residue-specific (rs) and embedding-like protein-specific (ps) 3DDPDs. The descriptors were developed by calculating distributions of trajectory coordinates and partial charges, applying dimensionality reduction, and subsequently condensing them into vectors per residue or protein, respectively. 3DDPDs were benchmarked on a number of PCM tasks against state-of-the-art non-dynamic protein descriptors. Our rs- and ps3DDPDs outperformed non-dynamic descriptors in regression tasks using a temporal split, and showed comparable performance with a random split and in all classification tasks. Combinations of non-dynamic descriptors with 3DDPDs did not result in increased performance. Finally, the power of 3DDPDs to capture dynamic fluctuations in mutant GPCRs was explored. The results presented here show the potential of including protein dynamic information on machine learning tasks, specifically bioactivity prediction, and open opportunities for applications in drug discovery, including oncology.
A Review of Phytochemical and Pharmacological Activities of Vitex negundo
Authors: Gandhimathi R  , Karthick Raja D  , Chandru Ganesh S  , Praveen. R. S  , Sivi Hirthikha. G. R  , Vijey Aanandhi M
Published: May 2023

Vitex negundo is a plant with medicinal properties that has been employed in traditional medicine to address a wide range of health conditions. This review summarizes the phytochemical and pharmacological activities of Vitex negundo. The plant contains various bioactive compounds such as terpenoids, flavonoids, alkaloids, and essential oils, which exhibit diverse pharmacological activities such as anti-inflammatory, analgesic, antipyretic, antioxidant, antitumor, antimicrobial, antifungal, and antiparasitic effects. Several studies have demonstrated the efficacy of Vitex negundo in the treatment of various diseases. The plant also possesses hepatoprotective, nephroprotective, and neuroprotective effects. However, further studies are needed to fully understand the mechanisms of action of Vitex negundo and to develop new drugs based on its bioactive compounds. In conclusion, Vitex negundo is a promising medicinal plant that deserves further investigation as a potential source of new drugs for the treatment of various diseases.
LITERATURA, FORMAÇÃO HUMANA E DOCENTE: VONTADES E UTOPIAS DE CRIANÇAS E ADULTOS NUMA BOLSA AMARELA
Authors: Oliveira Valdirene Val , Viana Cláudio Pires , De Souza Maria Erilande Ferreira
Published: May 2023

O presente texto tece considerações sobre a formação humana e docente e a literatura a partir da filosofia sartriana e dos pressupostos que fundamentaram a práxis de um subprojeto do curso de Pedagogia da Universidade Estadual de Goiás, na Unidade Universitária de Inhumas, participante do Programa Institucional de Bolsa de Iniciação à Docência (Pibid). O trabalho foi realizado mediante uma análise documental de registros individuais produzidos por um grupo de sete bolsistas, sendo sete relatórios finais e sete questionários com 10 questões respondidas pelas bolsistas após a conclusão do trabalho com o livro A bolsa amarela, de Lygia Bojunga Nunes. O estudo estabelece um diálogo entre os dados coletados e o referencial teórico que subsidiou os momentos de estudo e as práticas do subprojeto, em especial Cândido (1995), Benjamin (1996), Freire (1996), Siqueira (2013) e Valdez (2018). Por fim, o texto conclui que a humanização reivindica a literatura e que esta não comporta as fronteiras didático-pedagógicas que insistem em submeter adultos e crianças a padrões e estereótipos na lida do ensinar e do aprender.
A PRODUÇÃO CIENTÍFICA NO BRASIL SOBRE AS PARCERIAS PÚBLICO-PRIVADAS E A FORMAÇÃO CONTINUADA DE PROFESSORES
Authors: Pereira Mary Jose Almeida , MONTE DE CAMARGO ARLETE MARIA , Holanda Ramos Maely Ferreira
Published: May 2023

Este artigo tem o objetivo de construir um panorama da produção científica realizada no Brasil acerca das parcerias público-privadas na formação continuada de professores, fundamentado em pesquisas de periódicos encontrados na base de dados da Scientific Electronic Library Online e de periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, referentes ao período de 2006 a 2019. Essas parcerias se referem a contratos entre o poder público e o setor privado, no intuito de ofertar formação aos docentes em exercício na educação básica. Para tanto, após consulta aos objetivos de cada artigo, foram selecionados dez artigos a partir desse levantamento. Os resultados indicam que, apesar das parcerias público-privadas terem se expandido nas últimas décadas no Brasil, ainda são escassos os estudos que têm como objeto a formação continuada, o que nos leva a concluir que há a necessidade de ampliar o repertório das pesquisas sobre a temática, de forma crítica.
EDUCAÇÃO E DESENVOLVIMENTO HUMANO NO ENSINO SUPERIOR
Authors: Alves de Souza Estefani Gabrieli , Katiere Garcia Secatti Keysa , Tavares Guimarães Lucelia
Published: May 2023

O presente artigo contribui para a discussão sobre o desenvolvimento humano no ensino superior, e, dessa forma, destaca o desafio da permanência das mulheres na universidade durante o período pandêmico. Para isso, buscamos conhecer as condições particulares deste evento, juntamente com as questões generificadas que atravessam o modo como as mulheres se apropriam do conhecimento. Mediante o exposto, o percurso teórico metodológico descreve as relações de gênero e desenvolvimento humano no ensino superior a partir do referencial situado na teoria Histórico-Cultural e na teoria do Care. Dessa forma, realizou-se um estudo teórico bibliográfico com base no método materialista histórico-dialético para estabelecer quais são as implicações da evasão, absenteísmo e ausência de mulheres no Ensino Superior. Partimos do constructo de que o Ensino Superior proporciona o acesso às formas mais elaboradas de cultura e conhecimento construídos historicamente que são responsáveis pelo desenvolvimento das funções psíquicas superiores. Concluímos que o período pandêmico ratificou a cultura hegemônica do patriarcado no sistema capitalista, a qual atribui às mulheres funções sociais específicas do processo de produção e reprodução da sociedade, por isso, muitas destas funções, a maioria delas relacionadas ao cuidado, dificultou e impossibilitou o acesso e a permanência das mulheres na universidade.
The Growth of Pleurotus ostreatus Using Potato Dextrose Agar Supplemented with Waste Human Hair Broth (WHHB)
Authors:   Department of Microbiology, Faculty of Life Sciences, University of Benin, Edo State, Nigeria., Obuekwe I.S. , Odemwingie O.S.
Published: May 2023

Waste human hair causes environmental problems such as flooding, as a result of clogged drainages. It slowly breaks down over time to yield macro and trace minerals that are eventually returned to nature. Pleurotus ostreatus is cultivated worldwide, and it’s known to grow on several carbon and nitrogen sources. This study assessed the growth of P. ostreatus using potato dextrose agar (PDA) supplemented with Waste Human Hair Broth (WHHB). The growth of P. ostreatus mycelium was studied for 15 days on PDA supplemented with different concentrations of WHHB (0, 25, 50, 75 and 100% v/v) which was obtained by modified hydrolysis technique. Subsequent P. ostreatus growth was analysed using 0 and 100% v/v WHHB in grain spawn for 5 days. The physicochemical parameters and nutrient content of WHHB was analysed using standard methods, and mycelia growth was measured using standard methods. WHHB had a pH of 7.20 ± 0.02, temperature of 25oC and Protein content of 421.33 ± 3.06 mg/dL. Mycelia growth diameter and growth rate were significantly higher (p < 0 .05) in the 100% v/v WHHB relative to the control (0% v/v WHHB) after 15 days, and mycelium in 100% v/v WHHB grew luxuriously during spawn production after 5 days relative to 0% v/v WHHB. The pH and temperature values reported are optimal for the growth of P. ostreatus. Higher growth in WHHB is attributed to protein, macro and micro nutrients availability in the broth. The presence of nutrients in WHHB allowed for improved mycelium growth in the 100% v/v WHHB.
Consequences of Hydro-Priming Cola parchycarpa K. Schum. and Cola rostrata K. Schum. Seeds
Authors:   Department of Plant Science & Biotechnology, College of Natural Sciences, Michael Okpara University of Agriculture,  Umudike., Mukah F.E , Osuagwu G.G.E , Onyia R. , Ugwumba C.B
Published: May 2023

Hydro-priming is an important seed treatment technique for rapid seed germination. Cola species exhibits long and uneven germination. Hence this study was aimed at investigating the effect of hydro-priming durations on the germination and seedling growth of Cola parchycarpa and Cola rostrata. Five treatments (hydro-priming durations of 0 hour, 24 hours, 48 hours, 72 hours and 96 hours) were used and the experiment was laid out in a completely randomized design (CRD) with 6 replicates each. In C. parchycarpa, mean seed germination time of 40.50 days was observed only at 0 hour while there was no germination at 24, 48, 72 and 96 h of hydro-priming. In C. rostrata, there was a significant increase in the germination time as the hydro-priming duration increased from 0 h (13.83 d) to 48 h (45.00 d) with decreased germination percentage, while at 72 and 96 h of hydro-priming, germination failed to occur. There was no significant difference at P<0.05 in the seedling growth parameters of C. rostrata at the different hydro-priming durations. Hydropriming of C. parchycarpa and C. rostrata seeds before planting is not recommended for these two Cola species as it result in embryo death of the seeds.