bluuebunny/crossref_metadata_2025 huggingface dataset:
Російсько-українська війна як фактор, що живить торгівлю органами: кримінологічний аспект
Authors: Луценко І. Г.
Published: February 2025

Стаття присвячена факторам, що обумовлюють торгівлю органами в умовах російсько-української війни. Приділено увагу збільшенню даного виду злочинності за останній рік, враховуючи її латентний характер. Зокрема, окреслені об’єктивні причини існування торгівлі органами, як-от: нестача життєво необхідних органів як у світі в цілому, так і в Україні, корупція у різних галузях та наявність національної та транснаціональної злочинності. Акцентовано увагу на збройних конфліктах у Косово, Іраку та Сирії, під час яких збільшувався рівень злочинності, у тому числі торгівля органами. На підставі поточної ситуації в Україні та враховуючи закордонний досвід протікання збройних конфліктів, описано фактори, що детермінують торгівлю органами в умовах російсько-української війни такі як: послаблення або руйнування соціальних інститутів; економічна нестабільність держави і суспільства; масове внутрішнє і зовнішнє переміщення населення; збільшення осіб з адиктивною поведінкою; сприятливі умови для діяльності організованої злочинності; відсутність контролю за частиною державного кордону.
KUYPER, A. Mulheres da bíblia. Trad. Brian Gordon Kibuuka. Londrina: Penkal/Livraria Família Cristã, 2021.
Authors: Vale Rony Petterson Gomes do , Villar Aparecida Viviane
Published: February 2025

Não se aplica. Resenha.
traficante evangélico no Rio de Janeiro
Authors: Santos Lucineide
Published: February 2025

O texto explora a relação complexa entre o pentecostalismo e o tráfico de drogas no Rio de Janeiro, analisando como a fé evangélica se manifesta em um ambiente de violência e crime. O texto também debate o conceito de "traficante evangélico", explorando as diferentes perspectivas sobre a relação entre a fé e o crime, e as consequências da coexistência de ambas as realidades em um mesmo espaço. A figura do "traficante evangélico" no Rio de Janeiro é um fenômeno complexo e controverso que tem chamado a atenção da mídia e dos pesquisadores. Essa figura, que parece juntar conceitos aparentemente antípodas – religião evangélica e narcotráfico – levanta questões sobre a intersecção entre a fé, a criminalidade e a realidade social das favelas cariocas. A figura do "traficante evangélico", apesar de controversa, demanda uma análise cuidadosa e isenta de preconceitos. A compreensão desse fenômeno complexo contribui para um debate mais amplo sobre as relações entre a fé, a violência e a desigualdade social no Brasil.
Ensino Religioso no Amazonas – Estado da Arte
Authors: Barbosa Neto Manoel Vitor
Published: February 2025

O artigo trata-se de um trabalho na perspectiva chamada estado da arte (EA) a respeito do Ensino Religioso no Amazonas. Pesquisas de EA intencionam conhecer de maneira panorâmica o que se tem discutido a respeito de um assunto levantando material bibliográfico sobre determinada temática, no contexto dessa produção as obras selecionadas foram aquelas encontradas digitalmente em sites especializados. Ressalta-se que em trabalhos de EA conhecer significa que não basta saber da existência de textos científicos e catalogar, é necessário analisar para identificar as preocupações dos autores descobertos dentro desse recorte temático, de modo que ao final da investigação proposta por esse artigo seja possível obter dados relacionados as características dos estudos, os interesses recorrentes e também apontar as fragilidades da área. A conclusão desse trabalho aponta que temas como currículo, legislação educacional e o Ensino Religioso, relatos de experiência e formação de professores são recorrentes, bem como reconhece que o recorte temático “Ensino Religioso no Amazonas” é incipiente e recente, haja vista que foram publicadas nos últimos 10 anos.
Estratégias geopolíticas nas artes: o British Council e a representação britânica nas Bienais de Veneza e de São Paulo (anos 1950 1960)
Authors: Couto Maria de Fátima Morethy
Published: February 2025

Este artigo relaciona-se a Projeto Temático desenvolvido com apoio da Fapesp (Processo 2022/12333-3) e que tem como propósito mapear e analisar as mostras internacionais de artes visuais que circularam pelo Brasil e por outros países da América do Sul entre os anos de 1948 e 1978. O artigo discute o papel desempenhado pelo British Council no circuito internacional das artes dos anos 1950 e 1960, focando-se, sobretudo, nas escolhas do órgão para as representações britânicas para a Bienal de Veneza e para a Bienal de São Paulo. Procura demonstrar a articulação existente entre as seleções efetuadas para esses eventos e evidencia o sucesso das estratégias desenvolvidas pelo British Council no período.
Application Analysis of Multi-Task Learning Algorithm in E-Commerce Personalized Advertising Intelligent Push
Authors: Hou Min , Zhang Mengze , Zhang Yizhou
Published: February 2025

To improve the precision of personalized selection and push of e-commerce advertising content, a personalized advertising recommendation model based on improved Multi-Task Learning (MTL) algorithm is proposed. This study uses the data set of Specific Feature keywords (SFs) clicked by users and the basic facts of users' preference for selling keywords to increase the click-through rate of advertisements by adding personalized selling keywords in the advertisement title. Combined with the click-through rate prediction task as an auxiliary task, the prediction ability of the model is enhanced. Experimental results show that the model is better than the traditional method in terms of click-through rate, recommendation accuracy and efficiency. The Area Under the Curve (AUC) value of the model reaches 0.92, which is significantly improved compared with 0.81 of the traditional models, and the recommendation efficiency is increased by 14.26%. Through large-scale online and offline experiments, the superiority of the model in several indexes is verified. The model is particularly suitable for scenarios where users have rich clicking behavior in auxiliary tasks but sparse clicking behavior in main tasks. This study provides an effective method for optimizing the advertising push of e-commerce platforms
Design e emoção: a utilização da ferramenta PrEMO para testes em projeto de vitrina popular
Authors: Pinto Syomara dos Santos Duarte , Cunha Joana Luísa Ferreira Lourenço da , Romero Cláudia Buhamra Abreu , Quental Joana Maria Ferreira Pacheco
Published: February 2025

A partir do estudo do mercado popular de moda e de como o público se comporta em relação aos projetos de exposição em lojas, foi desenvolvida uma pesquisa que envolveu moda, vitrinas e emoções. As emoções despertadas por vitrinas e exposições populares encontraram em estratégias do design emocional maneiras de aferi-las e constatar sua sintonia com o público. Para tanto, ferramentas do design emocional foram desenvolvidas e este artigo apresenta a utilização de uma delas, PrEMO (Produto e instrumento de medição de emoção), de caráter qualitativo e quantitativo. Desenvolvida pelo Instituto Delft de Design Positivo (DIOPD), expressa catorze emoções por intermédio de desenhos, movimentos e sons. Como forma de avaliação e validação de um roteiro e mapa para projetos de vitrinas populares, a ferramenta foi aplicada em teste no projeto de três exposições. Os resultados dos projetos e seus testes são apresentados e considerados de formas qualitativa e quantitativa.
Prevalências de falha terapêutica e mortalidade em PVHA hospitalizadas em hospital universitário da Região Norte do Brasil
Authors: Lopes Carmen Andréa Freitas , Gomes Henrique Guimarães
Published: February 2025

Human immunodeficiency vírus (HIV) é um retrovírus que acomete o sistema imune e pode causar a síndrome de imunodeficiência adquirida (SIDA), predispondo infecções oportunistas e neoplasias. Este pode alcançar diretamente órgãos alvos comprometendo principalmente sistema nervoso central, cardiovascular e renal, impactando em síndrome demencial, aumento do risco cardiovascular e insuficiência renal, respectivamente. O presente estudo, transversal com amostra não probabilística de 206 Pessoas Vivendo com HIV/AIDS (PVHA) que foram hospitalizadas, se propôs ao estimar o itinerário terapêutico destas pessoas, identificar as prevalências de falha terapêutica, resistência genotípica secundária do HIV e o desfecho óbito expresso em taxa de mortalidade. Os dados foram coletados mediante registros em prontuários e consultas no LAUDO AIDS (sistema on-line do Ministério da Saúde).  A população estudada foi predominantemente do gênero masculino, com mediana de idade de 40 anos, apesentando vulnerabilidade social e estágios avançados da infecção pelo HIV. Sessenta e quatro por cento dos pacientes possuíam contagem de células TCD4 inferior a 200 células e 45,3% tinham cargas virais acima de 100.000 cópias de HIV-RNA. A prevalência de falha terapêutica foi de 29,7% e de resistência genotípica secundária foi de 15,7%, observando-se uma taxa de mortalidade de 24,3% em uma população cujo itinerário terapêutico mediano foi de 7 dias. Portanto, trata-se de uma população com grande vulnerabilidade socioeconômica e doença avançada pelo HIV, assim como elevadas taxas de resistência genotípica, falha terapêutica e mortalidade e com elevada quantidade de pacientes diagnosticados recentemente.
Avanços no diagnóstico e tratamento do Câncer de Colo de Útero
Authors: Campos Maria Letícia de Souza , Lima Maria Luisa Medeiros , Feitosa Maria Victoria Alvino , Costa Vitória Cavalcanti , Souza Alysson Kennedy Pereira de , Sousa Daniela Heitzmann Amaral Valentim de , Arruda Isabela Tatiana Sales de
Published: February 2025

O câncer de colo de útero é a principal causa de morte entre mulheres na América Latina e é a mais frequente neoplasia genital feminina em áreas subdesenvolvidas, assim, mostra-se a urgência deste artigo que tem por objetivo uma revisão integrativa sobre a detecção precoce de condições assintomáticas ou subclínicas, facilitando o desenvolvimento de estratégias de intervenção personalizadas e aumentando significativamente as chances de cura e sobrevida.
Análise do painel de transplantes no Rio de Janeiro nos três primeiros trimestres de 2023
Authors: Carvalho Maria Luiza Marcondes , Ferreira Priscilla Cristina Lopes , Silva Lohrane Menezes da , Tuza Fábio Augusto D’ Alegria , Lucena Glauco Macêdo de , Silva Gabrielle Lucas da , Cunha Paula , Couto Victor Rodrigues da Fonseca de Souza , Gomes João Márcio Nunes , Rios Danielle Camara de Vasconcelos
Published: February 2025

O maior programa público de transplante de órgãos, tecidos e células do mundo é brasileiro. Este é garantido a toda a população por meio do Sistema Único de Saúde, responsável pelo financiamento de mais de 85% dos transplantes no país. Objetiva-se entender a dinâmica, entre a oferta e a demanda, da transplantação realizada no território brasileiro, mais especificamente no Rio de Janeiro, nos três primeiros trimestres de 2023. Trata-se de um estudo ecológico, retrospectivo, descritivo acerca dos dados de transplante de tecidos e órgãos disponibilizados pelo Registro Brasileiro de Transplantes. O estudo foi feito a partir de dados secundários, baseado nos elementos apresentados pelo sistema de transplantes do território, sendo feito um recorte no estado do Rio de Janeiro, entre os meses de janeiro a setembro de 2023. Percebe-se que o número total de transplantes no território brasileiro, durante os meses de janeiro a setembro de 2023, foi de 6.559, contabilizando coração, fígado, intestino e entre outros. Sendo que os tecidos e a córnea foram transplantados 12.014 no total e o de medula óssea foram 3.062.  Portanto, notamos que os principais órgãos transplantados foram rins, fígado e coração em todo o território brasileiro. Entretanto, a maior demanda à nível nacional é de rim e no RJ córnea. A oferta de órgãos e tecidos é proveniente, na maioria das vezes, de pacientes que sofreram morte encefálica, sendo os homens mais acometidos.
Conhecimento e experimentação ao tabagismo entre adolescentes de escolas públicas estaduais em município de pequeno porte do estado de Mato Grosso, 2024
Authors: Santos Laiane da Silva , Ferreira Bruno Gonsalves , Lopes Sara Dayane , Teles Rafaella de Oliveira , Vidal Gabriela Cardozo Viana , Buhler Helena Ferraz , Souza Fellipe Augusto da Silva e , Buhler Beatriz Ferraz
Published: February 2025

No Brasil, as estatísticas mais recentes do tabagismo mostraram que a maioria dos fumantes no País, fumou o primeiro cigarro, antes dos 18 anos de idade. O objetivo deste estudo foi descrever o conhecimento e experimentação ao tabagismo entre os escolares de 14 a 19 anos de idade em escolas públicas estaduais em área urbana no município de Cáceres, Mato Grosso, 2024. Trata-se de estudo quantitativo e descritivo com a utilização de questionário por meio do google forms aplicados em quatro escolas públicas estaduais entre escolares do 9º ano ao 3º ano do ensino médio. Utilizou-se o software Excel para análise das proporções das categorias para cada questão. A análise mostrou que os escolares adolescentes não buscam e/ou utilizam os serviços de saúde para ações de prevenção primária. No que diz respeito ao conhecimento sobre tabaco, mostraram desconhecimento e/ou não consideraram a presença dessa substância entre outras tóxicas em dispositivos de entrega do mesmo de maior uso entre os jovens (cigarro eletrônico e/ou narguilé), sendo que 1/3 já teve interesse e/ou experimentou algum dos dispositivos. Neste último caso, aproximadamente 46% eram menores de 14 anos. Conclui-se a importância de ações de educação permanente em saúde acerca das substâncias presentes na constituição dos diversos tipos de dispositivos para fumar. Estas ações devem acontecer para além dos espaços escolares, como em locais que representem coletivos de jovens em parceria entre comunidade externa, a escola, equipe escolar e equipes de atenção à saúde primária.
Evidências recentes sobre miastenia gravis: revisão sistemática da literatura sobre abordagens diagnósticas e terapêuticas
Authors: Castro André Teixeira de Souza e , Amaral Katya de Souza do , Welker Carolina Flores
Published: February 2025

A Miastenia Gravis (MG) é uma doença autoimune de etiopatogenia ainda não completamente elucidada, caracterizada pela produção de autoanticorpos dirigidos contra os receptores nicotínicos de acetilcolina (AChR) na junção neuromuscular (JNM). Esse ataque imunológico resulta na destruição dos receptores, comprometendo a transmissão neuromuscular e desencadeando manifestações clínicas, como fraqueza muscular progressiva e fadiga dos músculos esqueléticos. Este estudo apresenta-se como uma revisão sistemática da literatura científica especializada, com o objetivo de analisar de forma abrangente os avanços no entendimento da Miastenia Gravis, abrangendo artigos nacionais e internacionais. Busca-se identificar novas abordagens terapêuticas e descobrir avanços recentes na compreensão de sua fisiopatologia. A finalidade é fornecer subsídios que contribuam para a redução das manifestações clínicas da doença, promovendo o desenvolvimento de estratégias diagnósticas e terapêuticas mais eficazes, com potencial para melhorar a qualidade de vida dos pacientes.
Las relaciones interpersonales en circuitos de proximidad: orientaciones para una masificación agroecológica desde un sujeto colectivo
Authors: Parada Santiago Peredo , Salas Claudia Barrera , Pavez Carolina Morales
Published: February 2025

El escalonamiento de las iniciativas agroecológicas requiere la construcción de sujetos colectivos desde la diversidad de actores implicados en los sistemas alimentarios. El objetivo de este trabajo es identificar las relaciones interpersonales entre distintos actores vinculados a la circulación de productos agroecológicos de la agricultura campesina en diferentes circuitos locales. El diseño metodológico fue cualitativo de tipo exploratorio mediante estudio de caso en el marco de una investigación acción participativa. Los resultados señalan actores con lo que se despliegan relaciones interpersonales más favorables y armoniosas. Así como actores donde se identifican tensiones en las interacciones. Finalmente, se entregan orientaciones para la ampliación de las iniciativas agroecológicas en torno a la significación del producto campesino, las relaciones entre actores y los canales de comercialización.
Caso clínico en delfín Tursiops truncatus del Acuario Nacional de Cuba
Authors: Zerquera Iván Pérez , Yero Manuel de Jesús Acosta , Amador Mara Leyva , Chan Alejandro Canul
Published: February 2025

El Acuario Nacional de Cuba durante el mes de noviembre del 2022 se presentó por primera vez, un caso cínico en uno de sus ejemplares de la especie Tursiops truncatus con diagnóstico presuntivo de cistitis polipoide sugestivo a tumor de vejiga con afectación renal. Se recopiló información que, unido a métodos complementarios como hemogramas, pruebas bioquímicas y ultrasonidos, determinaron que el diagnóstico inicial no correspondía con un tumor de tipo maligno. Esto permitió elaborar un protocolo de tratamiento en el cual el lavado vesical resultó ser eficaz para la mejoría y estabilización del ejemplar. Se recomienda emplear la cistoscopia y biopsia con aguja guiada por ecografía para hacer un diagnóstico diferencial preciso de las patologías de las vías urinarias, así como continuar los estudios referentes a la patología presentada en este estudio de caso.
Avaliação da mobilidade urbana sustentável na área central de Campo Mourão: um estudo comparativo utilizando o índice de mobilidade urbana sustentável (IMUS)
Authors: Amaral Isabela Coimbra , Souza Paula Cristina de , Souza Gabriela Maciel de , Mendonça Junior Gabriel de Freitas , Guilhem Bruna Fernanda de Andrade
Published: February 2025

A mobilidade urbana é crucial para o desenvolvimento sustentável das cidades, especialmente em áreas metropolitanas densamente povoadas, onde o aumento populacional gera impactos expressivos a curto e longo prazo. O Índice de Mobilidade Urbana Sustentável (IMUS), desenvolvido por Costa (2008), surge como uma ferramenta valiosa para analisar e melhorar os aspectos sociais, econômicos e ambientais da mobilidade urbana. Este estudo concentra-se na avaliação da mobilidade urbana sustentável na área central de Campo Mourão, utilizando o IMUS como ferramenta de análise. Os objetivos incluem calcular o IMUS, analisar estratégias para mobilidade sustentável e comparar os resultados com outras cidades similares. Os resultados obtidos revelam uma situação preocupante em Campo Mourão, destacando a necessidade de ações corretivas e investimentos estratégicos para melhorar a infraestrutura e os serviços de transporte na região. Os resultados desta pesquisa representam uma análise abrangente da mobilidade urbana sustentável na área central de Campo Mourão. Ao calcular o IMUS e examinar 87 indicadores distintos, foram identificadas lacunas significativas na mobilidade urbana da cidade. A comparação com Curitiba, uma referência internacional em mobilidade urbana sustentável, evidencia disparidades marcantes, ressaltando a necessidade de investimentos e políticas direcionadas para melhorar a eficiência e a sustentabilidade do transporte urbano em Campo Mourão.
Para enfrentar esses desafios, é essencial promover investimentos em transporte público, infraestrutura cicloviária e políticas de planejamento urbano sustentável. Além disso, é crucial considerar as especificidades locais e as demandas da população ao formular e implementar políticas e projetos de mobilidade urbana. A participação ativa da comunidade, o envolvimento de stakeholders e parcerias público-privadas podem ser instrumentos poderosos para impulsionar o progresso nessa área crucial para o desenvolvimento urbano sustentável.
Eksplorasi Aktivitas Antioksidan Biji Kepundung (Baccaurea racemosa) Dan Korelasinya Dengan Kandungan Fenolik Total
Authors: Permatasari Lina , Rohman Abdul , Riyanto Sugeng , Priya Haresmita Perdana
Published: February 2025

Dalam dekade terakhir, radikal bebas dapat menyebabkan banyak penyakit, misalnya kanker. Antioksidan merupakan senyawa yang mampu menghambat aktivitas radikal bebas. Indonesia memiliki kekayaan sumber daya alam yang bisa dieksplor aktivitas antioksidannya. Salah satu tumbuhan Indonesia yang potensial yaitu kepundung (Baccaurea racemosa). Bagian daun, batang, buah, kulit buah, dan kulit batang kepundung dilaporkan memiliki aktivitas antioksidan yang tergolong sedang sampai sangat kuat. Namun, aktivitas antioksidan biji kepundung belum pernah dilaporkan. Oleh karena itu, penelitian ini bertujuan untuk mengekplorasi aktivitas antioksidan biji kepundung dan korelasinya dengan kandungan fenolik totalnya. Biji buah kepundung diekstraksi dengan metode maserasi bertingkat diawali dengan pelarut petroleum eter kemudian dilanjutkan dengan kloroform lalu etil asetat. Ekstrak petroleum eter, ekstrak kloroform, dan ekstrak etil asetat biji kepundung dianalisis aktivitas antioksidannya menggunakan metode penangkapan radikal bebas 2,2’-diphenil-1-picrylhydrazil (DPPH). Sementara itu, kandungan fenolik total diuji menggunakan metode Folin-Ciocalteu. Korelasi antara aktivitas antioksidan dan kandungan fenolik total dianalisis menggunakan Person correlation test. Hasil menunjukkan bahwa ekstrak petroleum eter, ekstrak kloroform, dan ekstrak etil asetat secara berurutan memiliki persen penghambatan radikal DPPH sebesar 6,35 ± 0,97 %; 28,84 ± 5,48 %; dan 50,78 ± 1,18 %. Sementara itu, kandungan fenolik total ekstrak petroleum eter, ekstrak kloroform, dan ekstrak etil asetat secara berurutan yaitu 0,10 ± 0,01; 15,12 ± 0,52; dan 30,62 ± 0,87 mg ekuivalen asam galat/ gram ekstrak (mg EAG/g). Senyawa fenolik ekstrak biji kepundung berkorelasi positif dan signifikan dengan aktivitas antioksidannya. Senyawa fenolik berkonstribusi sebesar 98,9% terhadap aktivitas antioksidan biji kepundung. Biji kepundung dapat dikembangkan lebih lanjut sebagai antioksidan alami.
Pengembangan Sediaan Emulgel Ekstrak Etanol Teh Putih dan Minyak Biji Delima dengan Aktivitas Antioksidan dan Fotoprotektif
Authors: Priani Sani Ega , Syafnir Livia , Mulkiya Kiki , Fitrianingsih Sri Peni , Radina Faqih
Published: February 2025

White tea and pomegranate seed oil are known to contain many bioactive compounds that make them potentially have antioxidant and photoprotective activities. This study aimed to examine the antioxidant and photoprotective activities of white tea leaf extract and develop it in an emulgel dosage form. White tea is extracted with 70% ethanol at 600C. The extracts were tested for antioxidant activity by the DPPH method and for photoprotective activity by the Mansur method. White tea extract was developed into an emulgel with pomegranate seed oil as the oil phase, stearic acid and TEA as emulsifiers, and viscolam mac 10 as a gelling agent. The results showed that the ethanol extract of white tea had a very strong antioxidant activity with an IC50 value of 10.80 ± 0.75 ppm. White tea ethanol extract also has photoprotective activity with an SPF value of 12.35 ± 0.63, %Te value of 2.13 ± 0.01 %, and  %Tp value of 45.13 ± 0.08 % (ultra protection category). White tea extract has been successfully developed into an emulgel preparation with good characteristics and stability in terms of organoleptic, pH, viscosity, spreadability, and rheological behavior. White tea emulgel are stable based on centrifugation and freeze-thaw tests.
Uji Aktivitas Antioksidan Formula Minyak Herbal Dengan Metode 1,1-Diphenyl-2-picrylhidrazil (DPPH)
Authors: Wulandari Ayu , Nurhikmah Nurhikmah , Tandi Joni
Published: February 2025

Penelitian ini bertujuan untuk mengetahui stabilitas fisik serta aktivitas antioksidan formula minyak herbal pelita mas dengan menggunakan Metode 1,1-diphenyl-2- picrylidrazil (DPPH). Penelitian ini merupakan penelitian eksperiment laboratorium dengan rancangan untuk mengetahui nilai aktivitas antioksidan dengan menggunakan metode 1.1-Diphenyl-2-picrylhidrazil (DPPH) dan mengetahui stabilitas dari formula minyak herbal pelita mas. Analisis data menggunakan One Way Anova pada program SPSS. Hasil penelitian menunjukkan bahwa stabilitas formula minyak herbal seperti organoleptik, viskositas, kejernihan dan pH memenuhi syarat mutu sediaan minyak. Hasil pengujian aktivitas antioksidan formula minyak dan kuarsetin diperoleh nilai IC50 sebesar 101,328 ppm dan 4,623 ppm dimana formula minyak herbal pelita mas tergolongan antioksidan sedang dan kuarsetin tergolong antioksidan kuat. Hasil uji analisis statistik yaitu uji normalitas dan uji homogenitas menyatakan bahwa data terdistribusi normal dan homogen. Hasil uji One Way Anova diperoleh nilai sig. 0.000 (<0,05) hal ini menunjukkan perbedaan yang signifikan antara formula minyak herbal dengan kuarsetin.
Potensi Aktivitas Antimikroba Serbuk Effervescent Daun Saga (Abrus precatorius L) Terhadap Jamur Candida albicans
Authors: Karmila Mila , Idham Syamsinar , Syalsabila Nadifa , Ervianingsih Ervianingsih
Published: February 2025

Medicinal plants are plants with medicinal properties that can relieve pain, increase the body's resistance and kill disease germs. Saga leaves (Abrus precatorius L.) contain flavonoids, saponins and alkaloids which can function as antifungals. Flavonoids is a compound that has an antifungal effect so it can play a role in the healing process of canker sores caused by the fungus Candida albicans. The aim of this research is to determine innovation, antifungal activity and physical evaluation test results of saga leaf extract effervescent powder (Abrus precatorius L). Testing for the activity of the Candida albicans fungus was carried out by the agar diffusion method using disc paper. Evaluation of effervescent powder preparations includes organoleptic observations including shape, color, odor and taste. Apart from that, a flow rate test, pH test and dissolution time test were carried out. The research results showed that all preparations met the requirements based on the literature with the organoleptic test results being in powder form, green in color, and had a sweet and sour taste which did not change during the test. The pH test results for F1 were 6.25, F2 6.5 and F3 7. The flow speed test for F1 was 1.20 seconds, F2 1.24 seconds and F3 1.33 seconds. Test flow time for F1 2.31 minutes, F2 2.43 minutes and F3 2.27 minutes. Meanwhile, the antifungal test showed the diameter of the inhibition zone for the Candida albicans fungus. F1 of 17.16 mm is included in the strong category, F2 of 13.83 mm is included in the strong category and F3 10.66 mm is included in the strong category.
Formulasi Yogurt Sari Buah Belimbing Wuluh (Averrhoa bilimbi L.) Dan Pengaruhnya Terhadap Penurunan Kadar Glukosa Darah Mencit (Mus musculus)
Authors: Rahmayanti Rahmayanti , Mursyid Murni , Astari Chitra
Published: February 2025

Indonesia is a country that ranks 5th out of 10 countries with the highest number of diabetics in the world. One of the plants that can be used as an antidiabetic is the fruit of belimbing wuluh (Averrhoa bilimbi L.). This study aims to determine the physical quality of wuluh star fruit juice yogurt and determine at what concentration wuluh star fruit juice yogurt can affect blood sugar levels of mice (Mus musculus). Mice as test animals were induced glucose and compared its effectiveness with acarbose. In this study, 5 treatment groups were used, namely giving yogurt without juice (negative control), acarbose (positive control), 0.35 ml star fruit juice yogurt, 0.50 ml star fruit juice yogurt, and 0.65 ml star fruit juice yogurt. Blood glucose measurement was done for 3 days. The results showed that star fruit juice can be formulated in the form of yogurt, and meet the standards of good physical stability, namely organoleptic test, pH, and viscosity. In the antidiabetic test, the results showed that all concentrations could affect the blood sugar levels of mice, with a decrease of 90 mg/dl at a concentration of 0.35 ml, a decrease of 92 mg/dl at a concentration of 0.50 ml, and a decrease of 100 mg/dL at a concentration of 0.65 ml. It was concluded that the most effective concentration to affect the blood sugar levels of mice was a concentration of 0.65 ml with a decrease of 100 mg/dl.
Pengaruh Kemoterapi terhadap Kadar Hematologi pada Pasien Kanker Payudara di RSUD dr. Kanujoso Djatiwibowo Balikpapan
Authors: Nabilah Annisa , Prabowo Wisnu Cahyo , Kuncoro Hadi
Published: February 2025

Kanker payudara merupakan penyakit keganasan pada jaringan payudara yang dapat berasal dari epitel duktus maupun lobulusnya. Terapi kanker payudara dapat dilakukan dengan beberapa macam terapi, salah satunya adalah kemoterapi. Efek samping kemoterapi yang paling umum adalah mielosupresi yaitu penurunan kadar sel darah karena agen kemoterapi bersifat toksik terhadap organ pembentuk darah. Penelitian ini dilakukan untuk mengetahui gambaran pengaruh kemoterapi dalam menurunkan kadar sel darah pasien kanker payudara yang menerima kemoterapi di RSUD dr. Kanujoso Djatiwibowo Balikpapan periode Juli 2022 sampai Juni 2023. Penelitian ini bersifat deskriptif dengan desain cross-sectional.  Dari 82 sampel, pasien dengan kadar eritrosit dibawah normal sebanyak 50 pasien (60%); hemoglobin 79 pasien (96%); hematokrit 75 pasien (91%); neutrofil 20 pasien (24%); leukosit 25 pasien (30%); dan trombosit 7 pasien (9%). Kadar hematologi di bawah normal paling banyak adalah hemoglobin dan hematokrit
Formulasi Sediaan Krim Ekstrak Daun Petai Cina (Leucaena leucocephala Lam) pada Proses Penyembuhan Luka Insisi terhadap Kelinci (Oryctolagus cuniculus
Authors: Ningtyas Ichi Aprilia , Prabandari Rani , Nawangsari Desy
Published: February 2025

Chinese petai leaves (Leucaena leucocephala Lam) have metabolite compounds that can heal incisional wounds, namely flavonoid and saponin compounds which are made in cream dosage form. An incisional wound is a wound caused by a sharp instrument cutting the skin and underlying tissue. The aim of this research was to determine the physical properties of the cream and the percentage of treatment of incisional wounds by petai cina leaf extract cream. The method used was an experimental method with 6 test treatment groups. Group 1 was positive control (Povidone iodine ointment), group 2 was negative control (cream base), group 3 was 4% concentration, group 4 was 8% concentration, group 5 was 16% concentration, and group 6 was without treatment. The extraction method is by remaceration using 70% ethanol solvent. The results of the research show that the physical properties in the organoleptic test have a distinctive odor, brown color with a semi-solid shape. The homogeneity test shows that the cream is homogeneous with a spreadability of 5.48 cm ± 0.2, a sticking force of 12.56 seconds ± 0.19, pH range of 5.8 ± 0.12, and viscosity of 1293 ± 0.04 which meets the range test the physical properties of the cream preparation. The incision wound healing test showed that concentrations of 8% and 16% could provide a fast wound healing effect for 10 days with a wound healing percentage of 100%. It can be concluded that the formulated cream meets the requirements and the cream can heal incisional wounds with a percentage of 100% for 10 days.
Aktivitas Antibakteri Sediaan Sabun Cair Ekstrak Daun Waru (Hibiscus tiliaceus L) Terhadap Staphylococcus aureus
Authors: Irawanda Rahma , Umar Anugrah , Astari Chitra
Published: February 2025

Skin infectious diseases in humans are a very frequent type of disease, in the human population there are about 30% colonized by Staphylococcus aureus. The skin is the main defense against bacteria if the skin is no longer protected, it will be very easily infected with bacteria, fungi, viruses, protozoa and many other small groups such as Rickettsia, Mycoplasma and Chlamydia.waru plants (Hibiscus tiliaceus L) contain saponins, flavanoids, polyphenols and triterpenoid compounds. The purpose of the study was to determine the physical quality of the waru leaf extract liquid soap formula and to determine which waru leaf extract liquid soap formula has the best inhibition zone against Staphylococcus aureus bacteria. This type of research is an experimental method. The physical quality test of liquid soap showed that the liquid soap was stable. Testing antibacterial activity using the disc diffusion method, the results obtained by the clear zone in F1 show an average value of 25.75, F2 shows an average value of 19.4, and in F3 shows 30.4. From this study, good results were obtained on the physical quality of waru leaf extract liquid soap preparations in all formulas. Of the three best formulas, F3 and provides the greatest antibacterial effect with an average inhibition zone of 30.4 with a very strong category.
Keywords : Antibacterial, Waru leaf, Liquid soap, Staphylococcus aureus
Evaluation Of Antibiotic Use With Quantitative Methods at Sultan Agung Semarang Hospital
Authors: Heroweti Junvidya , Suswanto Suswanto , Johari Ahmad Mu’alim
Published: February 2025

Antimicrobial Resistant in Indonesia estimates that the data of deaths due to Antimicrobial Resistant in 2018 is around 700,000 people and this number will continue to increase to 10 million people by 2050. It is necessary to control antibiotic resistance by evaluating the use of antibiotics. The purpose of this study was to determine the quantity of antibiotic use at RSI Sultan Agung Semarang period July-December 2021. This research is observational with a descriptive research design and retrospective data collection. The population used was all medical record data of inpatients in the internal medicine ward who used antibiotics. There were 394 medical records that met the inclusion criteria. Data calculated using the ATC/DDD method is described descriptively and presented in the form of percentages and tables, percentages and tables. The results showed the total DDD value of the antibiotic was 81.56 DDD/100 patient days with a total Length of Stay (LOS) of 2,588 days. Antibiotics with the highest DDD value are Levofloxacin parenteral with a value of every 100 days of hospitalization 20.38 patients received the treatment with a dose of 0.5 grams every day. While antibiotics that enter the 90% DU segment are Levofloxacin (P), Ceftriaxone (P), Moxifloxacin, Cefoperazone Sulbactam (P), Ampicillin Sulbactam (P), Meropenem (P), Metronidazole (P), Cefixime (O), Azitromycin (O), Levofloxacin (O), dan Cefotaxime (P). As a consequence of the possibility of antibiotic resistance, its use should be strictly controlled.
Tingkat Kepuasan Pasien terhadap Pelayanan Kefarmasian Di Apotek X Periode Februari Tahun 2024
Authors: Putri Annisa Dwi Marita , Harsono Samuel Budi , Sarimanah Jamilah
Published: February 2025

Pelayanan kefarmasian tidak lepas dari kualitas pelayanan apotek itu sendiri. Hal ini sangat berkaitan erat dengan kepuasan pasien, dimana kepuasan pasien merupakan cerminan kualitas pelayanan kesehatan yang mereka terima. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kepuasan pasien terhadap pelayanan di Apotek X berdasarkan kehandalan, ketanggapan, jaminan, empati dan bukti fisik secara parsial dan keseluruhan. Metode yang digunakan pada penelitian ini adalah metode SERVQUAL (Service Quality) dengan dimensi Tangible (bukti nyata), Reliability (kehandalan), Responsiveness (ketanggapan), Assurance (jaminan), Empathy (keramahan). Sampel dalam penelitian ini adalah pasien atau keluarga pasien yang menerima pelayanan kefarmasian dan termasuk dalam kriteria inklusi dan teknik pengambilan sampel yang dilakukan yaitu purposive sampling. Analisis data menggunakan metode analisis gap (kesenjangan) yang dihasilkan dari skor harapan dan skor kenyataan pelayanan kefarmasian di Apotek X yang telah diukur dengan skala likert. Hasil dari penelitian ini pasien merasa puas pada dimensi tangible, responsiveness, dan empathy dengan nilai masing-masing gap 0,0533; 0,0150;0,0267. Hasil pada dimensi reliability dan assurance menyatakan bahwa pasien merasa tidak puas terhadap pelayanan kefarmasian dengan nilai masingmasing gap adalah -0,0367; -0,0033. Secara keseluruhan menunjukkan bahwa pasien merasa puas dengan nilai gap 0,011.
Uji Efek Analgetik Ekstrak Daun Kayu Putih (Melaleuca leucadendra) Terhadap Mencit Jantan (Mus musculus) yang Diinduksi Formalin 1%
Authors: Mewar Djulfikri , Mahulauw Muhammad Azril Hardiman , Ibrahim Marisa Anggia , Pelu Aulia Debby , Baktiar Nurhasfiana
Published: February 2025

Melaleuca leucadendra merupakan salah satu tanaman khas maluku yang secaratradisional digunakan untuk mengobati nyeri. Nyeri merupakan suatu kejadiansensori dan emosi yang tidak nyaman dan berhubungan dengan kerusakan padajaringan atau berpotensi terjadinya kerusakan pada jaringan. Tujuan penelitian iniuntuk mengetahui efek analgetik ekstrak daun M leucadendra pada mencit jantan (Musmusculus) yang diinduksi formalin 1% dengan melihat parameter fenotip hentakankaki dan jilatan kaki. Penelitian ini menggunakan 25 ekor mencit jantan dibagi dalam dalam 5 kelompok yang terdiri dari 5 ekor mencit. Kelompok I sebagai (kontrol negatif), kelompok II, III dan IV (kelompok perlakuan) yang diberi EKP dengan dosis masing-masing 10%, 20% dan 40%, kelompok V sebagai (kontrol positif). Pemberian sediaan uji diberikan secara intraplantar. Hasil penelitian menunjukan bahwa mencityang diberikan ekstrak M leucadendra 40% mengurangi jumlah hentakan kaki denganjumlah persen proteksi 90.72. Mencit yang diberi ekstrak M leucadendra 40% jugamemiliki efek analgetik ditandai dengan berkurangnya jumlah jilatan kaki selama 60menit dengan jumlah persen proteksi 75.98. Penurunan hentakan dan jilatan yangsignifikan terlihat pada semua kelompok perlakuan termasuk kelompok yang diberiekstrak M leucadendra 40% (p<0,0001). Efek analgetik ekstrak M leucadendra 40%sebanding dengan krim metil salisilat 30%. Kesimpulan, ekstrak M leucadendra dengandosis 40% memberikan efek analgetik pada mencit yang mungkin berguna untukmengatasi nyeri pada manusia.
Aktivitas Peningkatan Fagositosis Sel Makrofag oleh Ekstrak Etanol Buah Etlingera rubroloba A.D. Poulsen Pada Mencit Yang Distimulasi Antigen Mtb
Authors: Badia Esti , Yulianti Sri Samrina , Rusli Nirwati , Jabbar Asriullah , Malaka Muhammad Hajrul , Sahidin Idin , Ilyas Y. Muhammad
Published: February 2025

Peningkatan aktivitas fagositosis sel makrofag sangat dibutuhkan oleh penderita penyakit tubekulosis (TB) untuk melawan invasi patogenitas dari bakteri Mycobacterium tuberculosis (Mtb) dan mengatasi keparahan infeksi sehingga pengobatan akan lebih optimal. Pengoptimalan fagositosis sel makrofag dengan pemberian imunostimulator dari tumbuhan seperti buah Etingera rubroloba A.D Poulsen penting diungkap. Buah diyakini sebagai imunostimulator berdasarkan penggunaan empiris oleh masyarakat Sulawesi Tenggara untuk memelihara daya tahan tubuhnya serta menyembuhkan penyakit infeksi demam typhoid, dan secara ilmiah terbukti sebagai imunomodulator, antiinflamasi dan antioksidan. Tujuan penelitian ini adalah membuktikan aktivitas buah E. rubroloba meningkatkan aktivitas fagositosis sel makrofag pada penyakit TB. Jenis penelitian ini eksperimental menggunakan 30 ekor mencit jantan yang terdiri dari kelompok normal (tanpa infeksi Mtb), kelompok negatif (Na.CMC 0.5% + infeksi Mtb), kelompok positif (ekstrak meniran komersial + infeksi Mtb), kelompok ekstrak dosis 200 mg/kg BB + infeksi Mtb, kelompok ekstrak dosis 300 mg/kg BB + infeksi Mtb, kelompok ekstrak dosis 400 mg/kg BB + infeksi Mtb. Hewan uji diberikan perlakuan selama 7 hari dan pada hari ke-8 diinfeksi antigen Mtb (Esat-6)  secara intra perintonium. Peningkatan fagositosis sel makrofag dihitung dengan mikroskop, selanjutnya data yang diperoleh dianalisis statistik one way ANOVA dan uji post hoc tukey. Hasil penelitian menunjukan ekstrak etanol buah E.rubroloba terbukti meningkatkan aktivitas fagositosis sel makrofag pada mencit distimulasi Mtb yang berbeda signifikan dengan kontrol negatif (P<0.05). Penelitian ini berhasil mengungkap informasi ilmiah baru dari tumbuhan E.rubroloba sebagai imunostimulator pada infeksi TB, sehingga berpotensi dikembangkan sebagai agen imunostimulator baru pada penyakit TB.
Potensi Ekstrak Daun Kersen (Mutingia calabura L.) sebagai Sumber Antioksidan Alami Dalam Sediaan Eye Gel
Authors: Adlina Salsabila , Vikandari Sonya Nurizki , Fauziah Nurma Sari , Endah Srie Rezeki Nur
Published: February 2025

Kulit bawah mata merupakan bagian paling rapuh dan lebih rentan terlihat tanda kelelahan dan penuaan akibat meningkatnya radikal bebas. Untuk mengurangi tanda penuaan dibagian bawah mata dapat diatasi dengan menggunakan kosmetik yang mengandung antioksidan. Tujuan penelitian yang dilakukan ialah untuk membuat sediaan dengan bentuk eye gel menggunakan ekstrak daun ceri dan mengevaluasi sifat antioksidannya. Pada sediaan gel mata, ekstrak daun kersen dibuat dengan kekuatan formula I (1%), formula II (3%), dan formula III (5%). Hasil pengujiaan menunjukkan sediaan eye gel ekstrak daun kersen memenuhi parameter uji evaluasi fisik. Nilai antioksidan menunjukkan bahwa formula I memiliki nilai IC50 sebesar 83,742 ppm, formula II 73,936 ppm, dan formula III sebesar 66,154 ppm termasuk kedalam kategori aktivitas antioksidan yang kuat.
Edukasi Nutrisi penting Vitamin Yang Dibutuhkan Terhadap Ibu Hamil Dan Menyusui Untuk Memaksimalkan 1000 Hari Pertama Kehidupan Dan Mencegah Stunting Di Desa Powelua
Authors: Kurnia Utami Indah , Ali Indra , Puspita Dewi Niluh
Published: February 2025

Stunting is a type of problem in children caused by poor nutrition, especially if it lasts in the long term. This condition can be caused by malnutrition in pregnant women or when the child is growing. Powelua Village is one of the remote villages that receives little attention from the outside community. As a result of road access and difficult terrain to reach this village, the condition of this village is very lagging behind compared to other villages in this sub-district. The aim of this service activity is to socialize the importance of nutrition in the First 1000 Days of Life to prevent stunting. The method of this activity is carried out by providing outreach to residents using leaflets regarding important nutrition in the First 1000 Days of Life, then a question and answer session and distributing questionnaires to measure residents' understanding. As a result of the activity, the community was very enthusiastic and were able to increase their knowledge through the posttest questionnaires that were distributed. From the results of posttest calculations, it was found that 41% of the public knew the importance of nutrition in the first 1000 days of life. It can be concluded that this activity is very beneficial for the people of Powelua Village
Education on Indicators of Clean and Healthy Living Behavior in the Powelua Village Community, Donggala Regency, Central Sulawesi
Authors: Palipadang Matra Novalia , Dipayana I Made , Fince Maria , Ferdelita Putri
Published: February 2025

Clean and Healthy Living Behavior (PHBS) is a form of manifestation of healthy living orientation in individual, family and community culture, which aims to improve, maintain and protect health both physically, mentally, spiritually and socially. Clean and healthy living behavior is an effort to strengthen a person, group or community to care about and prioritize creating a higher quality life. To make this happen, it is necessary to educate the community about the implementation of PHBS. Community service aims to provide information about PHBS to increase knowledge and attitudes about the implementation of PHBS in the community. The method of implementing the service is a lecture using visual media in the form of a leaflet about 10 indicators of clean and healthy living behavior.  The target of implementing the service is the community of Hamlet 3, Powelua Village, Donggala Regency, Central Sulawesi Province, which will be carried out in June 2024 for one day. The instrument used was a questionnaire, with a total sampling technique. Analysis of community service results, namely univariate analysis in the form of a description of knowledge and attitudes about 10 PHBS indicators. The results of community service showed that the level of community knowledge about PBHS before being given counseling was sufficient, and after being given PBHS counseling, knowledge increased where the majority had good knowledge. The implementation of PHBS needs to be improved so that individuals can help themselves with health problems or participate in creating a healthy society in their environmentKeywords: PHBS; Indicators; Powelua.
Pelatihan Pembuatan Virgin Coconut Oil (VCO) dengan Metode Tanpa Pemanasan pada Masyarakat Pesisir Puu Lawulo Kabupaten Kolaka
Authors: Maulidiyah Maulidiyah , Nurdin Muhammad , Rismiati Rismiati , Irwan Irwan , Edihar Muh , Arham Zul , Zakir Muzakkar Muhammad
Published: February 2025

Virgin coconut oil (VCO) atau yang biasa dikenal dengan minyak kelapa murni adalah salah satu produk olahan dari buah kelapa. Kegiatan ini bertujuan meningkatkan pengetahuan dan keterampilan masyarakat pesisir Puu Lawulo, Kecamatan Samaturu, Kabupaten Kolaka dalam mengolah buah kelapa menjadi VCO. Metode pelaksanaan yang digunakan dibagi dalam tiga tahapan penting, yaitu tahap sosialisasi, demontrasi dan evaluasi. Dalam tahap sosialisasi, tim PKM melakukan penyuluhan kepada peserta kegiatan dengan menyampaikan materi dalam bentuk Powerpoint (PPT) terkait dengan cara pembuatan VCO dan manfaatnya dalam bidang kesehatan. Pada tahap demontrasi dijelaskan terkait langka-langkah pembuatan VCO dengan metode tanpa pemanasan. Tahap ketiga yaitu tahap evaluasi dilakukan untuk mengukur tingkat keberhasilan kegiatan yang telah dilakukan. Evaluasi dan peningkatan pengetahuan peserta kegiatan dilakukan melalui pre-test dan post-test. Hasil evaluasi setelah dilakukan post-test menunjukkan peningkatan yang signifikan dengan rata-rata skor mencapai 80-90%. Kegiatan ini menghasilkan produk berupa VCO yang dihasilkan dengan metode tanpa pemanasana. Luaran lainnya berupa kemampuan kelompok biru dalam membuat VCO secara mandiri
INTRODUCTION OF MEDICINE PREPARATIONS FOR HOUSEWIVES AT RW 003 TABARINGAN MAKASSAR
Authors: Sinala Santi , Teresia Rosmala Dewi Sisilia
Published: February 2025

Pemilihan bentuk sediaan akan mempengaruhi tingkat kepatuhan pasien yang akan berdampak pada keberhasilan pengobatan.  Pemberian obat secara oral adalah rute yang paling disukai oleh masyarakat karena menawarkan keuntungan seperti  kemudahan penggunaannya,  sangat  fleksibel,  dan  dosis  yang  akurat.
Masalah yang dihadapi oleh beberapa masyarakat adalah rendahnya pengetahuan tentang penggunaan obat yang rasional, masyarakat kurang memahami obat apa saja yang boleh dibeli tanpa resep dan harus memakai resep dokter. Selain itu, masyarakat juga kurang memahami pengelolaan obat di rumah seperti cara penggunaan obat yang sesuai dengan bentuk sediaan obat dan cara membuang limbah obat.
Pada dasarnya obat adalah racun, sehingga penggunaan obat harus sesuai dengan aturan pakai. RW 003 Tabaringan belum mengetahui tentang penggunaan obat yang benar dan baik, penyimpanan dan pembuangan limbah obat. Terkadang mereka mengkonsumsi antibiotik tidak sesuai aturan, menyimpan obat tidak pada tempatnya, serta membuang obat tidak sesuai metode-metodenya. Pengetahuan dan pemahaman yang kurang tersebut dapat menyebabkan pengobatan yang tidak maksimal dan limbah obat dapat membahayakan lingkungan. Oleh karena itu, dilaksanakannya pengenalan sediaan obat yang merupakan bagian dari GeMa CerMat (Gerakan Masyarakat Cerdas Menggunakan Obat).
Di  rumah,  banyak  ibu  rumah tangga  yang belum mengetahui bentuk sediaan obat yang sesuai dengan cara penggunaan dari bentuk sediaan obat, baik sesuai resep dokter dan obat-obatan yang biasa dibeli tampa resep dokter.   Ada beberapa obat yang menurut  pengetahuan ibu rumah  tangga sebaiknya obat tablet dikunyah agar efek dari obat cepat memberikan terapi pada tubuh. Ibu rumah  tangga  juga  mengaku  sangat  jarang membaca  kemasan  atau  brosur  obat,  namun  mereka  cukup  mengerti  perihal  obat  yang kadaluarsa, tidak bisa dipakai, dan harus dibuang ke tempat sampah.
Terkait permasalahan tersebut, diputuskan untuk memberikan penyuluhan dalam bentuk pembelajaran aktif terkait penggunaan obat sesuai dengan bentuk sediaan obat. Metode Penyuluhan ini dilaksanakan secara tatap muka dengan metode ceramah serta penayangan video/gambar bentuk sediaan. Dengan melakukan penyuluhan ini ibu-ibu rumah tangga dapat mendapatkan informasi mengenai cara membedakan bentuk sedian obat serta cara pengunaan yang baik dan benar.