bluuebunny/crossref_metadata_2025 huggingface dataset:
EKPHRASIS IN KEATS’S “ODE ON A GRECIAN URN”
Authors: Ristić Tatjana Z.
Published: February 2023

In order to fully question the issue of ekphrasis in John Keats’s ”Ode on a Grecian Urn”, this paper begins by giving a brief historical and theoretical framework of ekphrasis, and then analyses a concrete ekphrasis in Keats’s poem. Historically speaking, the meaning of ekphrasis made a large shift in modern times compared to the original. Ancient Progymnasmata do not narrow the term based on subject matter, but rather define it using the category of vividness, enárgeia, and only later through the examinations of ancient ekphrasis of works of spatial arts, in literary texts as well as in rhetorical ones, ekphrasis becomes narrowed to a literary evocation of works of spatial arts. This happens in Spitzer’s analysis of the poem in the second half of the twentieth century, thus proving “Ode on the Grecian Urn” to be a crucial text in rethinking the term. This paper tends to reconcile the original and modern theories of ekphrasis through the poem itself. In a theoretical context, ekphrasis’s share in narration and description, and its discursive features are shown, opening the debate on the common linkage of ekphrasis to description, and alienation from narration. Choosing to address ekphrasis from the perspective of the ekphrastic poetry itself rather than a theoretical point of view, the paper shows how the urn cannot solely be seen as “silent” since it strives to tell a legend, a narrative, which is contained in the urn as an aesthetic object and work of sculptural art. This text does not tend to discover the real models for the ekphrasis, but it does offer some sculptural works and paintings which could have inspired Keats. The text is more inclined toward unveiling the discursive context which could have influenced the poet: the (meta)aesthetics of ancient Greece, derived both from poetry and philosophy. The most important objective of the paper is to offer a new reading of the poem through a critical dialogue with the most accepted readings of the “Ode”, primarily those of Spitzer and Brooks, and through questioning of common places in literary criticism of the poem.
“FUI SOLDATO. QUESTA PAROLA ESPRIME TUTTO”. ANTIMILITARISMO E NEVROSI IN UNA NOBILE FOLLIA DI IGINIO UGO TARCHETTI
Authors: Pettine Simone
Published: February 2023

Obiettivo del presente saggio è l’analisi del romanzo Una nobile follia di Iginio Ugo Tarchetti, pubblicato per la prima volta in appendice alla rivista «Il Sole» tra il 1866 e il 1867. La critica si è già occupata in alcune occasioni dell’opera in questione, proponendone sempre una lettura antimilitaristica. Lo stesso Tarchetti, del resto, ideò il volume mosso da un’aperta e violenta polemica nei confronti dell’istituzione militare nel suo complesso (dalla leva obbligatoria agli eserciti permanenti, passando per la vita di caserma); tanto che Roberto Carnero, in anni recenti, ha considerato Una nobile follia un libro volto a demistificare ogni guerra e forma di violenza, al di là delle specifiche motivazioni storiche. La prospettiva adottata in questa sede è però inedita: senza prescindere dalle motivazioni ideologiche di Tarchetti, si tenterà di individuarne la riconferma e resa letteraria nella patologia del protagonista, Vincenzo D. La nevrosi di quest’ultimo viene infatti descritta come perfetta risultante della vita del soldato: Tarchetti descrive abilmente i vari stadi della malattia mentale, dovuta a condizioni storico-sociali sia esterne che interne; il tema della follia troverà poi spazio ancora più ampio, di lì a qualche anno, nel romanzo più famoso dell’autore, Fosca. Gli strumenti adottati nell’analisi sono quelli propri della critica testuale e del close reading.
DENIS DE ROUGEMONT AND THE WESTERN CONCEPTION OF LOVE
Authors: Šarić Željko M.
Published: February 2023

This paper analyses the key areas reached by the Swiss author Denis de Rougemont in his famous work Love in the Western World. We critically read de Rougemont's thought that love-passion, as the basic guiding thread of the myth of Tristan and Isolde, still sovereignly rules the unconscious being of modern man, giving him a one-sided vision of the play about love. Following his argumentation, we examine the connections between courtly and chivalrous love, Cathar heresy and troubadour love poetry. Denis de Rougemont contrasts eros, which ignites passion that descends into the darkness of death, with agape, i.e. the Christian love for one's neighbour. We question whether de Rougemont's solution to the problem of love by establishing merciful love as a necessary moral choice can be a satisfactory answer for modern man.
BROTHER OR CHAVAL: WHAT DO WE KNOW ABOUT THE SPEECH OF THE YOUNG?
Authors: Трифуњагић Даница Д.
Published: February 2023

BROTHER OR CHAVAL: WHAT DO WE KNOW ABOUT THE SPEECH OF THE YOUNG?
Assessment of the hydrological and coupled soft computing models, based on different satellite precipitation datasets, to simulate streamflow and sediment load in a mountainous catchment
Authors: Khan Muhammad Adnan , Stamm Jürgen
Published: February 2023

This study evaluated the performance and hydrologic utility of four different satellite precipitation datasets (SPDs), including GPM (IMERG_F), PERSIANN_CDR, CHIRPS, and CMORPH, to predict daily streamflow and SL using the SWAT hydrological model as well as SWAT coupled soft computing models (SCMs) such as artificial neural networks (SWAT-ANNs), random forests (SWAT-RFs), and support vector regression (SWAT-SVR), in the mountainous Upper Jhelum River Basin (UJRB), Pakistan. SCMs were developed using the outputs of un-calibrated SWAT models to improve the predictions. Overall, the GPM shows the highest performance for the entire simulation with R2 and PBIAS varying from 0.71 to 0.96 and −13.1 to 0.01%, respectively. For the best GPM-based models, SWAT-RF showed a superior ability to simulate the entire streamflow with R2 of 0.96, compared with the SWAT-ANN (R2 = 0.90), SWAT-SVR (R2 = 0.87), and SWAT-CUP (R2 = 0.71). Similarly, SWAT-ANN presented the best performance capability to simulate the SL with an R2 of 0.71, compared with the SWAT-RF (R2 = 0.66), SWAT-SVR (R2 = 0.52), and SWAT-CUP (R2 = 0.42). Hence, hydrological coupled SCMs based on SPDs could be an effective technique for simulating hydrological parameters, particularly in complex terrain where gauge network density is low or uneven.
PROBLEMS OF DEVELOPING THE SYSTEM OF CONSTITUTIONAL CONTROL IN THE CONSTITUENT ENTITIES OF THE RUSSIAN FEDERATION AFTER THE 2020 CONSTITUTIONAL REFORM
Authors: Rudman Mark N. , Turyanov Artur R.
Published: February 2023

This article analyzes the prerequisites for the 2020 constitutional reform, which abolished the institution of constitutional and statutory courts in the constituent entities of the Russian Federation. The author identifies the significance and factors for the development of regional constitutional justice, considered as one of the fundamental elements of Russian constitutional federalism. The study provides a detailed analysis of the arguments for liquidating the bodies of constitutional justice of the RF constituent entities with no options for ensuring effective constitutional control at the regional level, which seems to be a reflection of society’s low interest in maintaining the constitutional order. The leading reason for liquidating regional constitutional and statutory courts is the lack of a political request for their activities due to the underdevelopment of Russian federalism. The novelty of this research lies in identifying the relationship between the development of constitutional justice in the RF constituent entities and the political stability of the Russian state’s constitutional system. The author emphasizes the importance of the possibility of establishing constitutional justice bodies in the RF constituent entities for the development of domestic constitutionalism, which is preserved based on the current constitutional legislation. At the same time, the model, proposed within the 2020 constitutional reform and subjugating the regional constitutional justice to the RF subjects’ representative bodies, violates the constitutional principle of the judiciary’s independence. This article propose a hypothesis that the development of the constitutional basis of Russian federalism relies on the stability of the constitutional and statutory legislation of the regions. Consequently, the effectiveness of regional constitutional control is the foundation of the existing constitutional order. Therefore, the institutions exercising such control should be removed from the direct subordination to the representative bodies of the federation’s subjects.
NON-COGNITIVE CHARACTERISTICS OF HUMAN CAPITAL AND LIFE OUTCOMES
Authors: Khuziakhmetov Roman R.
Published: February 2023

The modern theory of human capital no longer interprets education, professional qualifications, and work experience as the only sources of income and labor productivity. There is a growing interest in the research of non-cognitive characteristics of human capital, which represent the socio-psychological qualities of an individual that affect the capitalization of knowledge and skills. The author focuses on such non-cognitive characteristics of human capital as self-efficacy, resilience, and agency. The article aims to analyze the relationship between non-cognitive characteristics of human capital and indicators of individual achievement (economic and non-economic). Applied descriptive sociological research is conducted in accordance with the positivist paradigm. Frequency distributions, comparison of averages, and correlation method are used in data analysis. The sampling represents the working population of the region (n = 1 261). The results show that self-efficacy, resilience and agency are represented differently in various socio-demographic, professional and status groups, but these differences are small. Life results are statistically significantly correlated with the values of the indices of non-cognitive characteristics of human capital. Correlations between economic achievements (job satisfaction, professional fulfillment) are higher than correlations with non-economic achievements (life satisfaction, confidence in the future). The author concludes that individuals demonstrate not only higher subjective assessments of life achievements, but also have higher wages if they are more confident in their abilities when solving work tasks, persistent in achieving professional goals, and independent in their activity.
CONSTITUTIONAL MODERNIZATION OF THE INSTITUTION OF LOCAL SELF-GOVERNMENT IN THE RUSSIAN FEDERATION
Authors: Nosova Natalya P. , Savelev Dmitrii L. , Alieva Olga V.
Published: February 2023

The article is an analytical study of the changes that have occurred as a result of the reform of the federal land of the Russian Federation. The authors consider the modern constitutional reform as a comprehensive systemic modernization of not only public administration bodies but also the social development of the country as a whole. The problem lies in the methodology of historical and legal discourse. Within the framework of the stated topic, the historical dynamics of constitutional changes and assessments of the institution of local self-government in Russia is analyzed. The authors historically consistently characterize the development of theoretical views on the problems of the institution under study, the features of the implementation of local self-government and its interaction with state bodies at different stages of historical development. The article analyzes the positions of Soviet constitutionalism in the field of public administration, and also attempts to assess the current state and modernization trends in connection with the latest amendments to the Russian Constitution. The analysis showed that the formed modern system of local self-government is the result of a long historical development of Russian society, which reflects the socio-cultural, political and economic features of both local territories and the state as a whole. The constitutional consolidation of the concept of “single system of public administration” is based on the key idea that building a unified system of public authority in Russian conditions can be progressively developed and be successfully implemented only within the framework of establishing a new balance of delineation of powers between all levels of government and their interaction on the basis of constructive dialogue. The authors come to the conclusion that an objective and systematic assessment of the change in the status of local governments in the updated structure of public authority can be fully implemented only after the completion of the process of reviewing federal and regional legislation based on the content of the norms of the updated Constitution, and their further application in practice.
Passive form of implementing the principle of information openness in the activities of public authorities
Authors: Karasev Anatoliy T. , Rukoleev Vitaliy A.
Published: February 2023

The system of implementation forms of the principle of information openness in the activities of public authorities in this publication is studied through the prism of the category of “interest”. Such a system involves two mechanisms for implementing the principle of information openness. Active form (an individual shows interest in obtaining information) and passive form (initiator of dissemination of information is a public authority). Each form is characterized by certain ways of obtaining information. The methods of obtaining information are characterized by a species diversity of information resources, and therefore it is inappropriate to analyze both forms at the same time, which does not allow describing both forms at the same time. With regard to the implementation passive form of the principle of information openness in the activities of public authorities, we analyzed disclosure of information in the media; placement of information on the Internet; placement of information in the premises occupied by public authorities, as well as in other premises. Particular attention is paid to the placement of information on the Internet. The paper analyzes not only informing with the use of official websites, but also with the help of public information and accounting systems (registries, registers, classifiers). It is proved that the federal legislator has not established a clear line between these information resources. The issue of legal regulation of the properties of information, in particular its reliability and officially, is briefly touched upon. Based on the results of the study of the passive form of implementing the principle of information openness in the activities of public authorities, proposals and recommendations for improving the current legislation are formulated.
Analysis of support measures for strategic organizations during the pandemic
Authors: Demidova Svetlana E. , Bloshenko Tatyana A.
Published: February 2023

The article is devoted to an overview of measures to support backbone organizations during a pandemic. In this context, the issue has not been addressed in other studies. The peculiarities of the group of backbone organizations were a significant increase in their number, in the structure the largest share falls on the industrial sector, in the regional context — on the capital region. However, the status of backbone organizations is not sufficiently substantiated. The criteria for referring to this group are controversial and, at the same time, can be ignored by the decision of the government commission. The measures of state support related to subsidizing bank loans provided to systemically important organizations, tax deferrals and other payments are being studied. The problems and risks for counterparties are indicated, due to the conditionality of the interest rate on loans. The main limitations for the use of support tools are given. We can conclude that the backbone status does not affect the composition of the support measures that a legal entity has the right to use. The advantage is that financial support is given priority. However, there is a possibility of disruption of the competitive environment as a result of this preference, as well as if the counterparty company is not subject to the moratorium on bankruptcy. It is proposed to change the approach to grouping organizations for the purposes of state support, with the allocation of sectoral priority. The article critically assesses the relevance of the proposed measures. It is proposed to diversify them through the use of refinancing and restructuring of already received concessional loans.
Proxy modeling pf reservoir hydrodynamics with graph neural networks
Authors: Umanovskiy Arseny W.
Published: February 2023

The primary goal of hydrodynamic reservoir modeling is to predict the production wells performance, or more precisely, the dependence of this performance on the choice of the reservoir development plan. The achievement of this goal is hampered by the lack of accurate information about the properties of the reservoir. These properties have to be inferred from indirect data, first of all from the historical indicators of already functioning wells. This information is used to perform the adaptation of the numerical reservoir model or proxy models, which are less informative but have the advantage of speed and flexibility. The article proposes a reservoir proxy modeling method based on the use of a specific artificial neural network (ANN). The novel graph convolutional architecture of the ANN takes in the graph data describing the reservoir. The edges and vertices of the graph contain a spatial description of the reservoir along with the history of the well performance. Such architecture makes it possible to train the neural network for a whole class of situations instead of only one case. In accordance with the principles of the Physics-Informed Neural Networks (PINN), the task of the ANN is to derive a kind of formulation of a physical law guiding the system, rather than just a correlation between time series. The advantages of this approach over most ANN-based proxy models used today are, firstly, speed: adjustment to historical data and forecast output are made in seconds even for hundreds of wells; secondly, a certain degree of physical meaningfulness.
Calculation of the flow characteristics of the heat carrier in the well considering the flow modes
Authors: Gilmanov Alexander Ya. , Shevelev Alexander P. , Rodionova Anna V.
Published: February 2023

Currently, the problem of depletion of easily recoverable oil reserves is urgent. Such a problem can be solved by involving in the development of fields with hard-to-recover reserves, which include high-viscosity oils. For the development of such deposits, thermal enhanced oil recovery methods are used to reduce the viscosity of oil, increase the inflow into producers. Among such methods, the cyclic steam stimulation is fully used the injected heat into the reservoir. One of the main problems of this method is the need to supply steam to the bottom of the well. This problem is relevant, since production with high water cut is formed in a number of fields as a result of cyclic steam stimulation, which indicates steam condensation even in the borehole. The article describes the construction of a physical and mathematical model of the injection of a heat carrier (steam — water) into the reservoir, considering the movement of it along the wellbore, heat loss through the walls of the well and flow modes for the first time. The aim of the work is to determine the influence of technological parameters on the characteristics of the heat carrier in the well, considering the flow modes. The mathematical model developed in the article is based on the laws of conservation of mass, momentum and energy, the friction pressure losses are calculated using empirical formulas for various flow regimes. The distribution of steam quality over the depth of the well, the influence of technological parameters on the wellhead (steam quality, pressure, heat carrier flow rate at the wellhead and thermal conductivity of thermal insulation) on the parameters of the coolant at the bottom of the well (steam condensation depth and heat carrier flow rate at the bottom) are obtained and analyzed. It is shown that with an increase in the thermal conductivity coefficient of thermal insulation, steam condenses higher along the borehole. It is determined that the higher the flow rate of the heat coolant at the wellhead, the deeper the steam penetrates through the well.
Ultrasonication Induced Alterations in Physicochemical and Functional
Properties of Myosin
Authors: Saleem Rashid , Ahmad Riaz
Published: February 2023

Background:

Several reports have indicated that ultrasonication can change the solubility
of muscle proteins and improves the functional properties of meat and isolated muscle proteins.
Moreover, available literature suggests that ultrasonication can significantly improve the gelling
properties of muscle proteins.

Objectives:

The present study was carried out to investigate the effect of low-frequency
ultrasonication on the secondary structure of myosin and the impact of these structural changes on
solubility and gelling ability.

Methods:

Myosin from breast muscles (Pectoralis major) of broiler chicken was extracted and
exposed to low-frequency ultrasonication for 30 min. Four aliquots collected at the interval of 5, 10,
20, and 30 min were analysed for change in ATPase activity, sulfhydryl content, surface
hydrophobicity, alpha-helicity. The possible impact of these changes on heat-induced gelation was
observed through electron micrographs.

Results:

Ultrasonication reduced the enzymatic activity of myosin and increased the reactive
sulfhydryl content. Decreased α-helicity and increased intrinsic fluorescence displayed significant
structural changes at the secondary and tertiary levels. Myosin aggregation, as indicated by electron
micrographs, showed a marked decrease. The microstructure of myosin gels displayed a distinct
correlation with ultrasonication-induced structural changes. Furthermore, improved microstructure led
to a significant increase in the water retention capacity of myosin gels.

Conclusion:

In conclusion, ultrasonication of myosin caused a marked change in structure at the
tertiary and secondary levels. Structural changes apparently confined within the globular head region
and rod portion of myosin were displayed by reduced enzymatic activity and improved
gelation/solubility. Results of our study convincingly showed that ultrasonication improved the
microstructure of myosin gels resulting in increased WHC.
Aloperine Prevents Migration, Invasion, and Adhesion by Upregulating
TIMP-4 in Human Bladder Cancer Cells
Authors: Qiu Mingning , Yu Liming , Liang Jinglan , Xia Juan , Wang Xuguang , Liu Jie
Published: February 2023

Background:

Aloperine (ALO) is an important active component of quinolizidine alkaloids
in Sophora flavescens A and Sophora alopecuroides L, and has effective anticancer activity against
multiple cancers. However, the influence and mechanism of ALO on migration, invasion, and
adhesion in bladder cancer cells remain unclear.

Objective:

The aim of this study is to determine the anticancer effect of ALO on migration, invasion,
and adhesion in bladder cancer cells and to investigate its potential TIMP-4-related mechanism.

Methods:

Cell viability, cytotoxicity, wound healing, Transwell invasion, cell adhesion, real-time
qPCR, western blot, and ELISA assays were performed to analyze the effect of ALO on migration,
invasion, and adhesion in bladder cancer 5637 and UM-UC-3 cells. Furthermore, the anti-TIMP-4
antibody was used to explore the potential effect on ALO-inhibited bladder cancer cells.

Results:

We have found that ALO significantly suppressed migration, invasion, and adhesion in
bladder cancer cells. Furthermore, ALO could downregulate the expression of MMP-2 and MMP-9
mRNAs and proteins, and increase the expression of TIMP-4 mRNA and protein. Moreover, the anti-
TIMP-4 antibody reversed the prevention of migration, invasion, and adhesion in ALO-treated bladder
cancer cells.

Conclusion:

The data in this study suggest that ALO suppressed migration, invasion, and adhesion in
bladder cancer cells by upregulating the expression of TIMP-4.
LSINCT5: A Novel lncRNA in Cancers
Authors: Qiu Xinyan , Chen Jinlan
Published: February 2023

Background:

Long chain non-coding RNAs (lncRNA) are a kind of transcript
that is around 200 nucleotides long and can engage in life activities via epigenetic, transcriptional,
and post-transcriptional regulation. One of the key members of lncRNAs,
long stress-induced noncoding transcripts 5 (LSINCT5), is localized at Chr 5p and has
been reported to be abnormally expressed in a range of cancers. We present a comprehensive
review of LSINCT5's aberrant expression and regulatory mechanisms in malignant
tumors.

Methods:

The included studies were retrieved and summarized through the PubMed
database using the keywords “LSINCT5” and “Cancer” in detail.

Results:

LSINCT5 behaves as an oncogene and abundantly expresses in malignant tumorigenesis
and progression. By sponging microRNAs (miRNA), interacting with proteins,
participating in cellular transduction, and being regulated by transcription factors,
LSINCT5 can stimulate malignant behavior in a variety of tumor cells, including proliferation,
migration, invasion, and epithelial-mesenchymal transition (EMT). Furthermore,
dysregulated LSINCT5 is usually associated with a poor prognosis.

Conclusion:

LSINCT5 has the potential to become a tumor diagnostic and prognostic
marker, generating new access to clinical applications.
In-vitro and In-vivo Identification, Absorbtion and Metabolism Network Analysis of
Filifolium sibiricum Flavonoids Dropping Pill by UHPLC-Q-TOF-MS
Authors: Ma Rui-Ting , Han Ji-Xin , Qiao Jun-Chan , Tong Li-Jun , Chen Li-Xia
Published: February 2023

Background:

Filifolium sibiricum flavonoids dropping pill (FSFp), a unique Chinese Filifolii sibirici
herba extract preparation, has the potential as an alternative therapy against S. aureus infection (SA) and antiinfection.
However, its chemical composition and in vivo metabolism characteristics remain unknown, which limits
its clinical application.

Methods:

Here, we aimed to understand the in vitro and in vivo material basis of FSFp. Ultra-performance liquid
chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) was used to identify
chemicals in FSFp as well as its phase I and phase II reaction metabolites in plasma, urine and feces.

Results:

A total of 38 chemicals were characterized in FSFp, including 22 flavonoids, 10 organic acids, 3 chromones,
1 aromatic ketone, 1 coumarin, and 1 ligan. After analysis of the drugged bio-samples, a total of 21 compounds were
found in urine, and 16 of them were found in feces, but only one was found in plasma. In addition, 56 FSFp-related
metabolites were characterized, of which 56 were in urine, 4 in feces, and 8 in plasma.

Conclusion:

This is the first comprehensive research of FSFp on chemical constituents and metabolic profiles. It was
expected that this study would offer reliable support for further investigation of FSFp.
Cancer-induced Pain Management by Nanotechnology-based Approach
Authors: Kundu Chanakya Nath , Dash Somya Ranjan
Published: February 2023

Cancer patients frequently report experiencing pain as one of their symptoms. Cancerrelated
pain is often caused by the tumor itself, especially when the tumor is pressing on nerves. In
addition to the pain caused by the tumor itself, patients also experience discomfort from the
treatment, such as surgery, chemotherapy, radiation therapy, and the diagnostic procedures. The
majority of today's pain therapies rely on opioid analgesics, which have not been shown to be
effective. The adverse effects of opioids and their addictive properties call for the development of
innovative treatment techniques. Nanotechnology offers answers to the issues raised above, which
are related to the utilization of more conventional modes of therapy. These nanotechnology-based
nanotherapeutics reduce the systemic toxicity, offering outstanding selectiveness and prolonged
release of the analgesic drugs at the target site. Thus, these reduce cancer-induced pain in the
patients. In this article, we will explain the mechanism behind the most common types of pain that
are caused by cancer, including neuropathic, somatic, and visceral pain. In addition, a
comprehensive discussion is held on the use of various nanotherapeutics as analgesic drug carriers,
as well as on their impacts and the potential opportunities that lie ahead in the field of cancer pain
treatment.
The Advances in Chitosan-based Drug Delivery Systems for Colorectal
Cancer: A Narrative Review
Authors: Ali Diyar Salahuddin , Othman Hazha Omar , Anwer Esra Tariq
Published: February 2023

Colorectal cancer (CRC) is considered a lethal cancer all around the world, and its incidence
has been reported to be increasing. Chemotherapeutic drugs commonly used for treating this
cancer have shown some drawbacks, including toxicity to healthy cells and non-precise delivery.
Thus, there is a necessity for discovering novel diagnostic and therapeutic options to increase the
survival rate of CRC patients. Chitosan, as a natural polymer, has attracted a lot attention during
the past years in different fields, including cancer. Studies have indicated that chitosan-based materials
play various roles in prevention, diagnosis, and treatment of cancers. Chitosan nanoparticles
(NPs) have been shown to serve as anti-cancer agents, which provide sustained drug release and
targeted delivery of drugs to the tumor site. In this paper, we review available literature on the
roles of chitosan in CRC. We discuss the applications of chitosan in designing drug delivery systems
as well as anti-cancer activities of chitosan and involved signaling pathways.
New Short RNA Motifs Potentially Relevant in the SARS-CoV-2 Genome
Authors: Fuertes Miguel Angel , Alonso Carlos
Published: February 2023

Background:

The coronavirus disease has led to an exhaustive exploration of the SARS-CoV-2 genome. Despite the amount of information accumulated, the prediction of short RNA motifs encoding peptides mediating protein-protein or protein-drug interactions has received limited attention.

Objective:

The study aims to predict short RNA motifs that are potentially interspersed in the SARS-CoV-2 genome.

objective:

The study aims to predict short RNA motifs potentially relevant in the SARS-CoV-2 genome

Methods:

A method in which 14 trinucleotide families, each characterized by being composed of triplets with identical nucleotides in all possible configurations, was used to find short peptides with biological relevance. The novelty of the approach lies in using these families to search how they are distributed across genomes of different CoV genera and then to compare the distributions of these families with each other.

Results:

We identified distributions of trinucleotide families in different CoV genera and also how they are related, using a selection criterion that identified short RNA motifs. The motifs were reported to be conserved in SARS-CoVs; in the remaining CoV genomes analysed, motifs contained, exclusively, different configurations of the trinucleotides A, T, G and A, C, G. Eighty-eight short RNA motifs, ranging in length from 12 to 49 nucleotides, were found: 50 motifs in the 1a polyprotein-encoding orf, 27 in the 1b polyprotein-encoding orf, 5 in the spike-encoding orf, and 6 in the nucleocapsid-encoding orf. Although some motifs (~27%) were found to be intercalated or attached to functional peptides, most of them have not yet been associated with any known functions

Conclusion:

Some of the trinucleotide family distributions in different CoV genera are not random; they are present in short peptides that, in many cases, are intercalated or attached to functional sites of the proteome.
Benzothiazole as a Promising Scaffold for the Development of Antifungal
Agents
Authors: Tratrat Christophe
Published: February 2023

Despite great efforts in the discovery of antifungal drugs in the last two decades, the increasing
incidence of infectious diseases from diverse pathogenic fungi threatens public healthcare
and medical sector. Particularly, the invasive infection caused by the yeast Candida Albicans in
immunocompromised patients has been widely reported with 25-55% of mortality rate. The major
concerns faced by the use of current antifungal agents are the development of fungal resistance, side
effects, toxicity, narrow spectrum of fungal activity, and constraints in the route of administration.
However, among the four known classes of antifungal drugs currently used in therapy against invasive
fungal infections, only one novel antifungal class has been approved by the FDA in 2021 for
medical use. In addition, two derivatives with the identification of their corresponding novel molecular
targets are currently in the last phase of clinical trial. In this context, the discovery of novel
compounds with potential antifungal activity needs to be explored urgently in order to address these
concerns. Among various heterocycles, benzothiazole presents a privileged scaffold for developing
bio-active compounds with a broad spectrum of pharmacological activities. Many derivatives incorporating
the benzothiazole core have been reported to display prominent activity against a variety of
non-resistant and resistant fungal microorganisms and have been found to be very attractive for the
development of novel antifungal agents. Therefore, in this review, the latest advances in the discovery
of benzothiazole-containing antifungal agents are summarized with an emphasis on their spectrum
of activity and their structure-activity relationship. We hope that this study will provide researchers
structural insight into antifungal molecules for the development of the next generation of
antifungal drugs.
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids
Authors: Kumar Aman , Rohila Yajat , Kumar Vijay , Lal Kashmiri
Published: February 2023

Molecular hybridization is one of the recent stratagems in medicinal chemistry to synthesize
a novel hybrid molecule having better affinity and efficacy by combining two or more pharmacophoric
moieties. Molecular hybridization, i.e., a linker or framework integration technique, can be
used to connect the two pharmacophoric components. It has often been found that hybrid compounds
perform more effectively and possess lower toxicity than their parent molecules. In order to
create a new generation of effective and safe therapeutic candidates, such as anti-cancer, anti-viral,
anti-HIV, antioxidant, and antibacterial, for a variety of frontline diseases, several articles have been
published that discuss the molecular hybridization of preclinically or clinically proven compounds.
Isatin and its derivatives have been studied extensively due to diversified biological activities, including
antitumor, antimicrobial, anti-inflammatory, analgesic, antiviral, antioxidant, anticonvulsant,
etc. Similarly, 1,2,3-triazoles have received significant interest as a bio-isostere in medicinal
chemistry for generating a large number of pharmaceutically significant molecules. As it possesses
diversified physiochemical properties, such as hydrogen bond formation capacity, ease of synthesis,
moderate dipole moment, stability towards acidic/basic hydrolysis, inertness towards oxidizing/
reducing agents, and good binding potential with several biological targets, triazole is an important
choice of the medicinal chemists for the novel medication development. The aim of the current
review is to summarize the research articles showing the pharmacological significance of hybrid
molecules containing isatin and 1,2,3-triazole moieties. The present review may assist chemists
in designing and synthesizing isatin-1,2,3-triazole hybrids with better efficacy and low cytotoxicity.
In silico Exploration of Interaction Profile of Fructan 6G-Fructosyltransferase
(6G-FTT) Enzyme with its Substrate 1-Kestose From
Cichorium Intybus in Order to Determine Active Site of this Conjugation
Authors: Taj Gohar , Ahamad Shadab , Upadhayay Viabhav Kumar , Tiwari Apoorv
Published: February 2023

Chicory, or ‘Cichorium intybus’, is an erect perennial herb that can be used to treat a
variety of diseases, including enteric sickness, diabetes, haemorrhoids, malaria, allergies, digestive
issues, and more. The enzyme, called 6G-FFT, uses 1-kestose as a substrate for the synthesis of
the more complex and branched fructans. To understand the residues involved in this conjugation
reaction between 6G-FFT and 1-kestose, molecular docking study was performed. The amino acids
ASP157, ASP33, SER32, TRP57, GLU211, ASP244, and GLU117 of the 6G-FFT protein
showed a good interaction with the ligand by SP (Standard Precision) docking studies. Results for
XP (Extra Precision) docking studies also suggest the amino acids THR153, GLU117, ASP244,
GLU211, TRP57, ASP33 and ASP157 interact with the docking score of -10.6 Kcal/mol. Among
these interacting amino acids, GLU117, ASP244, GLU211, TRP57, ASP33, and ASP157 were
found to be common in both methods. This in silico study will be beneficial for further exploring
conjugation reactions in Cichorium intybus.
MRI Findings of Periarticular Lesions with Isolated Greater Tubercle
Fractures and Dislocation
Authors: Yoon Yu Sung , Cha Jang Gyu
Published: February 2023

Purpose:

To identify MRI findings for injuries to periarticular soft tissue structures that
were related to isolated greater tubercle fracture.

Materials and Methods:

16 patients (mean age: 53.8, range 30-71 yrs) were enrolled and diagnosed
with isolated greater tubercle (GT) fracture with CT and MRI and underwent shoulder arthroscopy
from September 2009 to April 2019. Two musculoskeletal radiologists were blinded to the patient
history and arthroscopic surgical findings and reviewed patient’s CT and MRI. Fracture displacement,
fracture center, and presence of bony Bankart lesion with Hill sachs lesion were checked on shoulder
CT. Soft tissue injuries, including rotator cuff injury, deltoid muscle injury, long head of biceps tendon
injury, capsular injury, glenoid injury, and injury location of the subscapularis and infraspinatus were
checked on shoulder MRI.

Results:

MRI showed supraspinatus injury (56.3%), subscapularis injury (56.3%), deltoid muscle injury
(25%), infraspinatus injury (25%), teres minor muscle injury (37.5%), injury of the long head of the
biceps tendon (43.8%), inferior glenohumeral ligament tear (87.5%), superior labral anterior-toposterior
lesion (25%), Bankart lesion (18.8%), and Hill-Sachs lesion (6.3%). 88.9% of subscapularis
injuries and 75% of infraspinatus injuries showed caudal predominance. All of the patients with infraspinatus
injuries showed concomitant teres minor muscle injuries. In order of frequency, the fracture
centers were anterior (25%), posterior (31.3%), and all (43.8%). For patients with Bankart and Hill-
Sachs lesions, the fracture center included the posterior portion in all cases.

Conclusion:

MRI and active arthroscopic examinations may be valuable when an isolated GT avulsion
fracture is identified on X-ray examination.
Calcified Fibrin Sheath Embolism of Bilateral Pulmonary Arteries: A
Second Case of the Literature
Authors: Gürhan Abdi , Kılınçer Abidin
Published: February 2023

Introduction/Background:

Central venous catheters, which provide a unique convenience
in the management of critical patients, have many advantages, as well as early and late complications.
Early complications include pneumothorax, vascular perforation, hematoma formation, air embolism,
or catheter malposition that may occur during or shortly after catheter insertion. Late complications
include infection, venous stenosis, catheter thrombosis, and catheter tip migration. In the literature,
embolization of a calcified fibrin sheath due to a central venous catheter to the pulmonary artery has
been reported only in one case

Case Presentation:

The purpose of this report is to present bilateral pulmonary artery embolism in a
patient who presented with cough and chest pain caused by calcified fibrin sheath of the port catheter
removed before that was used for regular chemotherapeutic infusions due to liposarcoma, as the second
case in the literature with imaging findings. The patient underwent medical treatment, and as a result of
the treatment, symptoms regressed.

Conclusion:

Central venous catheters have many complications, and although it is rare, pulmonary
embolism is one of them. The embolism of a calcified sheath is even rare, but it is still possible. However,
an embolism can cause significant morbidity and even mortality for a patient if it occurs. As physicians,
we should be aware of this entity to diagnose.
WITHDRAWN: Imaging Features of Primary Non-Hodgkin’s Lymphoma
of Long Bones
Authors: Gao Bu-Lang , Han Zeng-Wu , Wu Yuan , Han Shu-Man , Cao Lei , Liu Chang , Yang Chen , Yang Hui-Hui , Wu Wen-Juan , Yu Bao-Hai
Published: February 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

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of their article is transferred to the publishers if and when the article is accepted for publication.
Natural Compounds for Carcinoma Therapy by Wingless Signaling Pathway
Down-regulation
Authors: Ojha Smriti , Mishra Rahul Kumar , Mishra Sudhanshu , Singh Amrita , Kumari Shweta
Published: February 2023

Cancer is a prominent cause of death that places a significant financial strain on the healthcare system. Because of its prevalence, there is unquestionably unmet need for new chemotherapeutics. Atypical activation and deregulation of the wingless (Wnt) signaling pathway are considered one of the major causes of various types of carcinomas. This receptor activation is directly correlated with the activation of β -catenin and β -catenin-dependent transcription. In the modern era of drug development, natural compounds have shown to be an unrivaled source of anticancer medications. Herbal compounds have been identified as potent β-catenin signaling inhibitors, mainly by their downregulation, modulating its phosphorylation, increasing ubiquitination and proteasomal destruction, blocking nuclear translocation, or other molecular mechanisms. In vitro and in vivo studies have revealed that these natural product inhibitors can prevent and treat cancer in a variety of cancer models. Natural products have the potential to be promising novel molecules for cancer treatment, making them an essential topic of study. The importance of natural products in blocking the numerous signaling pathways that promote carcinogenesis is explored in this review, paving the way for developing and discovering anticancer medicines.
Analysis of Organic Components in Various Butyl Rubber Closures and
their Compatibility Study with Cefamandole Nafate by HPLC/GC-MS
Authors: Xu Bingyong , Gao Jiarui , Tang Kaixian , Zhang Fengmei , Liu Shan , Su Weike , Wang Jian
Published: February 2023

Background:

To control the quality of various butyl rubber closures and assess their
applicability to cefamandole nafate, HPLC/ GC-MS methods were developed to qualitatively and
quantitatively analyze the organic components in various types of butyl rubber closures and drug
powder of cefamandole nafate for injection, and migration of these components from rubber closures
to drug also were studied.

Materials and Methods:

The chemical components in the rubber closures and corresponding
drug were identified by GC-MS in full scan mode and NIST mass library. A GC-MS method in
SIM mode was established to quantitatively analyze siloxane compounds, aromatic hydrocarbons
and saturated chain-hydrocarbons in rubber closures and drugs. An HPLC method was established
to quantitatively analyze antioxidants and sulfides from rubber closures and drugs. The
turbidity values of powder for injection were measured by a turbidimeter. Further, the correlation
between the content of organic components in the drug and the clarity of the solution was analyzed.

Results:

It was found that the chemical components were released from butyl rubber closures and
migrated to the drug, which influenced solution clarity of cefamandole nafate for injection and
was the main factor to cause solution turbidity of powder for injection. The gradual migration of
components occurred over time with the use of common butyl rubber closures, but the coated butyl
rubber closures (rubber plated with membrane) were coated with a polytetrafluoroethylene
film to block the contact between rubber closures and the drug, and could effectively prevent the
migration of the components from rubber closures to drugs. The organic components in the butyl
rubber closures were mainly identified as siloxanes, saturated chain-hydrocarbons, and antioxidants.
An unknown ingredient was identified as 1-piperidinecarboxaldehyde, and trace amounts
of toxic toluene were also detected within limits.

Conclusion:

It is suggested that rubber plated with membrane or rubber closures of high quality
were applicable to cefamandole nafate for injection and should be used in its production. HPLC/
GC-MS methods can be used as an effective method for quality control of butyl rubber closures
and compatibility research with drugs to ensure drug safety for the public.
Biogenic Synthesis of Different forms of Bio-caped Silver Nanoparticles
using Microcystis sp. and its Antimicrobial Activity
Authors: Omar Rania , Ibraheem Ibraheem B. M. , Hassan Sherif , Elsayed Khaled N.M.
Published: February 2023

Background:

Nanobiotechnology is a cutting-edge field that is revolutionizing the
way we produce and utilize nanoparticles. With bacteria becoming increasingly resistant to traditional
antibiotics, researchers are exploring new ways to synthesize antimicrobials.

Objective::

The aim of this study was to investigate the biosynthesis of different forms of silver
nanoparticles using different biological methods from Microcystis sp. to be used as an antimicrobial
agent.

Methods:

We employed the direct strain powder method, ethanolic extract pellets, and ethanolic
extract. Then a combination of analytical techniques was used to characterize the properties of
nanoproperties. Finally, we evaluated the antimicrobial activity of the AgNPs against a panel of
bacteria and fungi.

Results:

AgNPs were found in various forms, such as cubic, spherical, and rod shapes. UV-Vis
detected a peak at 420 nm, and SEM identified the AgNPs with bio-capped layers ranging from
40-130 nm. The antibacterial test revealed that the pellet method produced the most effective
AgNPs, specifically against Gram-positive bacteria such as Staphylococcus sp. with a clear zone
of 32 mm, while the larger cubic AgNPs produced by the powder method were less effective as
antibacterial agents.

Conclusion:

This study demonstrates that AgNPs can be produced using Microcysts sp. as a
reducing and capping agent; furthermore, they are produced in different shapes as cubic, spherical,
and rod shapes. Besides that, cubic nanoparticles are more effective in killing germs than
spherical ones. The results of this study will help to improve our understanding of the mechanisms
of AgNPs biosynthesis and pave the way for the development of new and more effective
antimicrobial agents.