bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of vegetovascular malfunction in primary dysmenorrhea pathogenesis
Authors: Kokh L. I. , Kapilevich L. V. , Kologrivov K. A. , Fyodorova T. V. , Koshelskaya Ye. V.
Published: April 2021

Peculiarities of vegetovascular malfunction at functional dysmenorrhea has been investigated. 107 women with dysmenorrhea and 10 healthy women have been examined. Methods of pelvis minor organ rheography, rheoencephalography and cardiointervalography have been used. It has been revealed that at women with dysmenohhrea a disorganization  of  pelvis  minor  regional circulation developed during the first phase of menstrual cycle. It was evident in simultaneous decrease of cerebral vessel blood filling and increase of venous drainage, development of microcirculation disturbances. Simultaneously the enhancement  of  sympathetic effect and decrease of the effect degree of parasympathetic nervous system have been observed. On the contrary, at healthy women it is observed the enhancement of parasympathetic effect and the hemodynamic factors remain fixed.

The obtained results are evidence that at women with dysmenorrhea the marked vegetovascular disturbances connected with sympathetic tone prevalence and being evident mainly at cerebral hemodymanics level take place in the first  days  of  menstrual cycle. The nature of revealed disturbances is connected with the peculiarities of disease clinics.
Intraosseous autoserotherapy of lumbar osteochondrosis
Authors: Perveyev V. I. , Sukhanova G. A. , Perveyev I. V. , Avakov M. I.
Published: April 2021

138 patients with lumbar osteochondrosis (LOC) in age of 32—73 years with apparent pain syndrome and neurologic manifestations have been examined, these patients have received 316 autoserotherapy (AST) procedures. It has been revealed that in LOC patients a disturbance of coagulation blood properties and micricirculation as well as immunoglobulin M and G concentration increase, circulating immune complexes (CIC) increase, increase of kinin activity by more than 2 times had taken place. Course of AST procedures permits to decrease the blood coagulability and kallikrein activity almost up to the norm, to improve the microcirculation (by capillaroscopy data), to eliminate the disimmunoglobulinemia that is accompanied by the decrease of disease symptom evidence. Inclusion of AST procedures in LOC treatment complex decreases in short time the intensity of lumbar pains, decreases the hospitalization duration by (9,4 ± 1,1) days, increases the remission duration as compared to the control patient group that received the traditional treatment only.
Thyroid gland affection during Hodgkin’s disease
Authors: Rumyantsev A. A. , Kolesnikova O. I. , Voloskova N. I. , Bakanov A. A.
Published: April 2021

A clinical description of thyroid gland affection at 13-year child with Hodgkin’s disease is presented. The diagnostics process of this disease has been shown, it has been recommended an oncologic alarm in children practice.
Economical analysis of diagnostic study at women with inflammatory diseases of pelvis minor organs
Authors: Chernikova L. Yu. , Yevtushenko I. D. , Grishin A. V.
Published: April 2021

Practice of treatment standard application experiences the certain difficulties. On the one hand, the most treatment standards lay on insufficient economical base, on the other hand, the limitation of health protection in bankroll leads to the insufficient treatment efficiency.

An analysis of diagnostic study costs in Tomsk special treatment-and-prophylactic institutions has been made on the example of inflammatory pelvis minor organ diseases.

The results of the investigation have shown that the character of diagnostic study of patients with inflammatory pelvis minor organ diseases differed significantly from the treatment standard. At the same time this fact defines not only the necessity of expense increase for diagnostic study but, first of all, the necessity of changes of diagnostic study structure that has been proved by modern pharmaeconomical methods.
Surgery of «low» rectal cancer — prospects of modern oncoproctology
Authors: Zherlov G. K. , Bashirov C. P. , Pankratov I. V. , Chepezubov D. G.
Published: April 2021

Use of endoscopic ultrasonography in diagnostics of rectal low-ampullar malignant neoplasms has permitted to the authors to define the list of intersphincteric resection indications consisted in total mesorectumectomy and rectal and interior sphincter resection. The method of spheroidal reservoir formation with artificial unstriped muscular sphincter-cuff has been developed for the prophylaxis of anal incontinence and multimoment emptying after intersphincter resection with the colon bringing down. 14 patients have been operated with survey time up to 3,5 years. According to the data of clinical investigations the spheroidal reservoir form with small initial size and with the ability to extensibility as well as autonomous obturator function of striped muscular sphincter have become the basic conditions for the restoration of continence act and stool frequency in far period after intersphincter resection.
Contents of plasmin, α1-antitrypsin and α2-macroglobulin in blood of patients with cerebral infarction and discircular encephalopathy before the treatment
Authors: Kuznetsova N. A. , Chirikova T. S. , Krayushkina N. A. , Zorina V. N.
Published: April 2021

The aim of this investigation was to define the concentrations of serum proteinase — plasmin — and some of proteinase inhibitors, such as α2-macroglobulin (MG) and α1-antitrypsin (AT), in order to study their role in cerebral infarction (CI) and discircular encephalopathy (DE) pathogenesis. We have investigated 30 patients with cerebral infarction, 30 patients with discircular encephalopathy and 60 serum samples of the healthy people as a control. Plasmin (Pl), AT and MG levels have been defined with rocket immunoelectrophoresis method. We have found a significant Pl decrease in both group patients as compared to the control. The decrease has been (95,83 ± 4,3) mkg/ml in CI patients’ serum, (83,49 ± 3,79) mkg/ml in DE patients and (112,98 ± 2,66) mkg/ml in the control group. AT concentration has been increased in DE patients’ serum [(2,44 ± 0,15) g/l], MG concentration has decreased significantly [(1,08 ± 0/09) g/l] as compared to the control. On the contrary, MG serum concentration (1,72 ± 0/08 g/l) in CI patient group has not differed from the control [(1,64 ± 0,04) g/l] but it has been accompanied by AT level increase [(2,50 ± 0,16) g/l at patients and (1,78 ± 0,04) g/l at control]. We think that these differences can be used during differential diagnostics of the investigated diseases.
Peculiarities of immune system functioning of patients with endometrium cancer depending on the tumor differentiation grade
Authors: Pashov A. I. , Tskhai V. B. , Kamzalakova N. I. , Platonova L. N.
Published: April 2021

The aim of investigation is to define the peculiarities of immune system functioning of patients with endometrium cancer depending on the tumor differentiation grade. 133 female patients of comparable age in menopause have been examined: healthy women, patients with histological verified high-, medium- (1-st group) and low-differentiated (2-nd group) endometrium adenocarcinoma of the I stage. Estimation of the immune state has been made in accordance with generally accepted recommendations. Immune system activation has been stated in the 1-st group, in the 2-nd group there has been marked a dissociation of the function of basic immune system chains and a decrease of their functional abilities.
Pathomorphological predictors of left heart ventricle dilatation at ischemic cardiomyopathy patients with chronic cardiac decompensation in postoperative period
Authors: Kazakov V. A. , Kozhevnikov M. L.
Published: April 2021

Morphofunctional state of left ventricle (LV) myocardium and right atrial (RA) auricle at 31 ischemic cardiomyopathy patients with chronic cardiac decompensation has been investigated in details. Histological preparations colored with hematoxylin and eosin and by Mallory method have been studied with usual light and polarization microscopy. The correlation of morphofunctional state of ventricle myocardium and atrium has been found, the factors of unfavorable farther results of operational treatment of this patient category have been revealed: presence of morphological myocarditis picture and marked LV myocardium fibrosis were pathomorphological predictors of LV dilatation in late postoperative period.
Cochlear implantation as a prospective trend of a hearing aid
Authors: Starokha A. V. , Davydov A. V.
Published: April 2021

A fundamentally new method of the treatment of patients with a profound degree of deafness – cochlear implantation – has been described. During operation a system of electrodes providing the sound perception by electrical stimulation of survived auditory nerve fibers is to introduce into the patient’s inner ear. The scheme of cochlea implant has been presented, the selection of patients and postoperative rehabilitation stages have been described.
Comparative efficacy of the use of different etiotropic therapies of urogenital clamidiosis during the second half of pregnancy period
Authors: Antonova S. S. , Yuryev S. Yu. , Rostova S. A. , Gabidulina T. V. , Goncharova N. N. , Yevtushenko I. D. , Kokh L. I.
Published: April 2021

Analysis of pregnancy course, labor and early neonatal period at 294 women and their new-born children has been made for the estimation of the efficacy of different antibacterial therapy variants of urogenital clamidiosis during the second half of pregnancy period. The danger of abortion and chronic intrauterine fetal hypoxia are most often gestational process complications revealed against chronic urogenital clamidiosis. The use of sumamed is course dose of 3 g is an optimum pharmacotherapeutic regimen during the second half of pregnancy period.
Depressive-anxious disorders in clinical picture of bronchial asthma combined with erosive-ulcerous affections of gastroduodenal zone
Authors: Ustjuzhanina Ye. A. , Chernyavskaya G. M. , Beloborodova E. I. , Kornetov N. A.
Published: April 2021

In the paper a popularity frequency and peculiarities of depressive-troubled disorder (DAD) course at patients with bronchial asthma (BA) have been estimated depending on the presence of associated erosive-ulcerous affections of gastroduodenal zone (EUA GDZ) and an impact of DAD on BA course has been studied. Depressive-anxious disorders have been revealed at 87 (78%) of 112 interrogated patients, most of them had the depression of medium degree that had required a therapy with the possible antidepressant use. Combined disorders in the form of depression and anxiety prevailed. It has been found that persons of the older age were subjected to the risk of DAD development. Patients with mixed pathology had more expressed DAD.
Pharmacochemical investigation of species of Saussurea herbal plants
Authors: Nurmukhametova K. A. , Krasnov Ye. A. , Bychkova N. K. , Khoruzhaya T. G. , Dudko V. V. , Adekenov S. M. , Drab A. I. , Martynova Ye. N.
Published: April 2021

The ways of searching of herbal antiparasitic means for the alternative treatment of the prevailing diseases – lambliasis and opisthorchosis – have been examined.
Changes in peripheral nervous system at participants of accident consequences elimination in Chernobyl APP and population of the Tomsk northern industrial center
Authors: Porovsky Ya. V. , Zhankova V. I. , Ryzhov A. I. , Kalyanov Ye. V. , Tetenev F. F.
Published: April 2021

A clinical, electroneuromyographic (ENMG) and pathomorphological investigation of 19 eliminators of accident consequences (EAC) in Chernobyl APP in 1986 and 27 Tomsk region inhabitants living in the accident area that has taken place at radiochemical plant of Siberian Chemical Complex in 1993 has been made with the aim of the influence study of low ionizing radiation levels on the peripheral nervous system. Symptoms of sensory polyneuropathy prevailed in both groups clinically. Mixed affection type has been found at EAC by ENGM method, affection of myelinic nerve fibre membrane has been found at people living in accident trace area. Morphofunctional changes in skin allow considering the role of immune system in mechanisms of neuroglial and neuronal damages, distant by time.
M.F. Popov (1854—1919) — a founder of forensic medicine chair in Tomsk city (to the 150th anniversary of birth)
Authors: Alyabjev F. V. , Shamarin Yu. A. , Melchikov A. S.
Published: April 2021

In the article there is presented a biography and scientific interests of the outstanding scientist, a founder of forensic medicine chair, a professor of the Tomsk Emperor’s University M.F. Popov. Materials containing the process of formation of forensic medicine chair of the oldest Siberian institute of higher education are presented.
Detection of bartonella DNA in ixodid ticks, mosquitoes and in patients blood in Novosibirsk region
Authors: Morozova O. V. , Petrozhitskaya L. V. , Chernousova N. Ya. , Mirzayeva A. G. , Dobrotvorsky A. K. , Morozov I. V.
Published: April 2021

Bartonella DNA was detected using nested PCR in ticks Ixodes persulcatus and Dermacentor reticulatus, in mosquitoes Aedes cantans, but not in other mosquito or gnat species. Phylogenic analysis of the PCR product nucleotide sequences proved the infec- tion of arthropod vectors and human blood with Bartonella henselae, Bartonella quintana or their mixed infection in Novosibirsk region.
Modern approaches to study of Rickettsiales
Authors: Rudakov N. V. , Shpynov S. N. , Samoylenko I. E. , Kumpan L. V. , Reshetnikova T. A.
Published: April 2021

We describe wide distribution and considerable biological and genetical heterogeneity of Rickettsiales in Russia and Ka- zakhstan. R. sibirica subsp. sibirica, R. sibirica subsp. BJ-90, R. slovaca, R. helvetica, R.heilongjiangensis, R.aeschlimannii, R.tarasevichiae were detected in Siberia and Russian Far East. Our results show circulation of R.massiliae genotypes (R.sp.RpA4, R.sp.DnS14, R.sp.DnS28) in Dermacentor ticks, Ehrlichia muris, Anaplasma phagocytophila, «Schotti variant» — in I. persulcatus, H. concinna — in A. bovis. Role of new genotypes of .1Proteobacteria in infectology is in need of further specification.
The study of anaplasma and ehrlichia genetic variability in parasitic systems in the South-Western Siberia and Ural
Authors: Rar V. A. , Livanova N. N. , Panov V. V. , Astanin V. B. , Livanov S. G. , Morozova O. V.
Published: April 2021

Ehrlichia muris and Anaplasma phagocytophilum DNA were detected using nested PCR among Ixodes persulcatus collected in Novosibirsk, Sverdlovsk and Chelyabinsk regions and in blood samples of small mammals from Novosibirsk and Sverdlovsk re- gions. Two genetic variants of A. phagocytophilum were revealed in blood samples and ticks from Novosibirsk region.
Выявление различных видов риккетсий у иксодовых клещей, в крови людей и мелких млекопитающих на юге Западной Сибири и на Урале
Authors: Igolkina Ya. P. , Fomenko N. V. , Livanova N. N. , Astanin V. B. , Gosteeva L. A. , Chernousova N. Ya. , Rar V. A.
Published: April 2021

We investigated ticks, human blood samples, specimens of tissue and blood from small mammals using nested PCR. We de- tected high prevalence Rickettsia tarasevichiae and Rickettsia sp. RpA4 in samples of ticks Ixodes persulcatus and Dermacentor re- ticulatus, correspondingly. We observed DNA of pathogenic Rickettsia helvetica and Rickettsia slovaca in I. persulcatus and Der- macentor marginatus and DNA of Rickettsia sibirica in human blood and in blood and liver samples of small mammals.
The clinical-epidemiological characteristics of tick-borne rikkettsiosis in Baikal regions
Authors: Aitov K. A. , Zlobin V. I. , Malov I. V. , Borisov B. A.
Published: April 2021

The clinical-epidemiological characteristics of tick-borne rikkettsiosis in Eastern Siberia is given. Prevalence of the disease in villages is higher comparing towns. The carrier of infection is Dermacentor ticks which live in steppe and forest-steppe zones closer to dwellings. Medium course of disease is prevailed and the prognosis of disease is good.
Clinical-epidemiologycal characteric of tick neuroinfections at children
Authors: Pomogaeva A. P. , Karavaeva M. O. , Obidina O. V.
Published: April 2021

Piculiarities of tick-borne encefalitis and Lyme borreliosis at children in Tomsk region have been stadid from 1990—2004. Characte- ristiks of clinical forms of tick-borne in acute period at 264 children and 224 children Lyme borreliosis in acute period was presented.
Differential diagnostics and special specific prophylaxis of tick-borne infections in Irkutsk city
Authors: Kozlova I. V. , Zlobin V. I. , Verkhozina M. M. , Khasnatinov M. A.
Published: April 2021

The results of differential express diagnostic of tick-borne encephalitis and Lyme borreliosis agents in ticks, removed from pa- tients are present in this article (1995—2004). The entire complex of serolological and genetical methods were used. The specific prophylaxis based on the results of diagnostic had shown to be very effective for both infections. The first data about human ehrli- chiosis and anaplasmosis in Irkutsk region had been obtained. The improvement of diagnostic and prophylactic procedures are pro- posed.
Molecular and cellular basis of pathogenesis of tick-borne encephalitis
Authors: Nasyrova R. F. , Ryazantseva N. V. , Zhoukova N. G. , Zima A. P. , Zhoukova O. B. , Chechina O. Ye. , Lepyokhin A. V. , Chasovskikh N. Yu. , Novitsky V. V.
Published: April 2021

Main features of pathogenesis of tick-borne encephalitis virus’ persistense and outcome of the disease are determined by a complex xharacter of interaction between the virus and immune system of a patient. One of the main terms of pathogenetically im- portant virus activation is a low immune resistanse of an organism. The current article discusses role of modification of cellular dif- ferentiation, intercellular cooperation and cytogenetic instability of immunocytes as well as apoptosis as leading features of immu- nopathogenesis of tick-borne encephalitis.
Modern clinical manifestations of tick-borne encephalitis in Tomsk region
Authors: Zhoukova N. G. , Lepyokhin A. V. , Loukashova L. V. , Nasyrova R. F. , Ryazantseva N. V. , Karpova M. R. , Zima A. P. , Dobkina M. N.
Published: April 2021

The article presents the results of clinical and epidemiological investigations of morbidity rate of tick-borne encephalitis (TBE) in Tomsk region in a period of 1944—2005. it is shown that Tomsk region is an active natural focus of TBE, leading among other regions of the Russian Federation in morbidity rate and spreading of the infection. Main features of pathomorphosis of clinical ma- nifestitions of TBE were analysed: prevailing of fever and latent forms was determined, as well as decrese of paralytic and menin- geal forms levels.
Influence of the reactogenity of the tick-borne encephalitis vaccines on the immune response in vaccinated people
Authors: Leonova G. N. , Krylova N. V. , Pavlenko Ye. V. , Maystrovskaya O. S.
Published: April 2021

In present review the connection of the reactogenity of tick-borne encephalitis (TBE) vaccines not only with high content of the alien proteins, but also with content of the specific antigen for TBE virus was shown. By the example of vaccine «Encepur Adult» (Germany), containing neither polygeline and human serum albumin, feebly marked postvaccinal reactions was considered as positive fact, essentially influencing on the activity of the specific immune response.
Influence of dalargin on secretory function of liver
Authors: Rudin I. V.
Published: April 2021

Ifluence of intraperitoneal and intracerebroventricular dalargin ( and  opioid agonist) on bile secretion and composition was studied in white rats with intact and denervated liver. Dalargin was demostrated to alter bile composition significantly both intraperitoneally and intracerebroventricularly and effects were opposite. Intact liver innervation is a must for intracerebroventricular dalargin to have its effect on bile secretion.
Analysis of diagnosis mistakes in pediatry
Authors: Balasheva I. I. , Louchinina R. N. , Bocharova M. N.
Published: April 2021

Causes of diagnosis mistakes in pediatry are analyzed. Clinical examples are given.
Endosurgical treatment techniques of progressive tubal pregnancy
Authors: Yevtushenko I. D. , Rybnikov S. V.
Published: April 2021

Research purpose: to increase the efficiency of endosurgical treatment of women with progressive tubal pregnancy. Research method: prospective analysis. Research subjects: in 75 female patients, to whom salpingotomy and salpingorrhaphy had been per-formed, tubal patency was found; in 10% - tubal patency was laboured; in 9,5% of patients there was an obstruction. In 52,9% of women, to whom salpingotomic orifice was not sutured, tubal patency was found; in 32,4% of patients tubal patency was disturbed; in 14,7% the fallopian tube was obstructed and in 17,6% of patients tubo-peritoneal fistula formed. Uterine pregnancy rate of salpingotomy and salpingorrhaphy - 34,1%, of women, to whom salpingotomic orifice was not sutured - 20,6%. Performance of endoscopic salpingotomy with suture of the defect at isthmial and ampullar location of the fetal ovum helps to increase the efficien-cy of surgical treatment of the ectopic pregnancy.
Clinical-morphological peculiarities of the first trimester of pregnancy on the background of chronical urogenital chlamydiosis
Authors: Yuriev S. Yu. , Krotov S. A. , Antonova S. S. , Goncharova N. N. , Mustafina L. R.
Published: April 2021

Comparison of clinical manifestation of various forms chlamydial infection with a ultrasonic picture and cytomorphological characteristics decidua basalis in the first trimester of pregnancy was carried out. The basic clinical markers were colpitis, endocervicitis and threat of fetus wastage. At percistence the pathogene more significant changes echoscopy pictures were found. Expressed stromal edema and increase of expression of a receptor to IL-2 on a lymphocyte membrane at active chlamydial infection were found during morphological research of the decidual tissue. Stability of a population of the big granular decidual lymphocyte СD56++ at any form of urogenital chlamydiosis was revealed.
Clinical manifestations of connective tissue systemic injury in women of early reproductive age having small pelvis varicosis
Authors: Mozes V. G. , Mozes K. B.
Published: April 2021

The aim of the study was to define manifestations of non-differentiate forms of connective tissue dysplasia in women of early reproductive age having small pelvis varicosis. The study results showed that patients having small pelvis varicosis revealed more often phenotype manifestations of non-differentiate forms which were seen in clinical examination. Increased level of serum sialic acids and increasing excretion of connective tissue metabolites (free oxyproline and glycosaminoglycanes) with urine were consequence of connective tissue systemic injury in these patients which is in accordance with data of non-severe dysplasia process. The study performed allowed to conclude that the small pelvis varicosis in women of early reproductive age is a manifestation of systemic injury of connective tissue.
Peculiarities of hemopoiesis in Chernobyl event liquidators who live in the Tomsk region
Authors: Porovsky Ya. V. , Domnikova R. S. , Tetenev F. F.
Published: April 2021

Results of peripheral blood analysis, performed annually during 12—14 years in 83 Chernobyl event liquidators and of the marrow which was analyzed once, at the end of abovementioned period in 23 participants are given. Changes in peripheral blood showed increased number of reticulocytes, lymphocytes, monocytes and decreased number of thrombocytes. Cellular structure of the marrow revealed decreased mean number of myelocytes, basophil and polychromatophil normoblasts and increased number of lymphoid and monocyte population cells. The deflections revealed in the hemopoiesis system may serve as reflection of continuing regeneration processes in the bone marrow and increased amount of somatic pathologies.
Viable and creative way of the honoured scientist of Russia, Associated Member of RAMS, professor-pathoanatomist A.S. Zinovyev (1926—2003). To the 80th anniversary
Authors: Fyodorova G. V.
Published: April 2021

The article is devoted to the 80-anniversary of the Associated Member of RAMS, the honoured scientist of Russia, professor of the Omsk State Medical Academy Anton Samuilovich Zinovyev (1926—2003). Main landmarks of his creative way, services of the famous scientist-pathoanatomist in scientific, paedagogical and social activity are described.
The role of nervous system in the regulation of hemopoiesis
Authors: Goldberg Ye. D. , Dygai A. M. , Skourikhin Ye. G.
Published: April 2021

Plastic change of hemopoietic tissue in experimental neurotic influences is under control of distant and local regulating mechanisms. Changes in compartments of erythroid and granulocitar hemopoiesis are due to specific spectrum of neuro-mediating systems. Receiving instructive information from the central nervous system is via αand β-adrenergic receptors on cell elements of hemopoiesing precursors. Manifestation of tropism of hemopoiesis to αor β-аdrenergic mechanisms is associated with nervous influence type. Existence of two different directions of plastic change of hemopoietic tissue in experimental neuroses : activation of blood system according to stressor type (conflict situation) and hemopoietic disturbances (deprivation of paradox sleep) is explained by the activity of regulation mechanisms.
Molecular basis of disregulation of programmed lymphocytes’ death in chronic viral infection
Authors: Novitsky V. V. , Ryazantseva N. V. , Zhoukova O. B.
Published: April 2021

The review analyses information from recent literature and results of the authors’ own investigations concerning imbalance of programmed cell death in forming chronic viral infection. Molecular mechanisms of apoptosis modulation of immune cells by persistent viruses are discussed in the article.
Pathology of the immunity: reason or consequence of a tubercular infection?
Authors: Novitsky V. V. , Ourazova O. I. , Strelis A. K. , Voronkova O. V. , Filinyuk O. V. , Shilko T. A.
Published: April 2021

Actual issues of modern phthisiology concerning tubercular infection immune pathology and nature of immune imbalance during primary and secondary tuberculosis are considered in the article. Literature and original data which are basing mechanisms of Т-cellular deficiency development in patients with drug-sensitive and drug-resistant pulmonary tuberculosis are analyzed.
Hormonal-metabolic changes in blood serum of rats in acute period after general controlled hyperthermia as a manifestation of hypermetabolism syndrome
Authors: Yefremov A. V. , Pakhomova Yu. V. , Michourina S. V. , Pakhomov Ye. A.
Published: April 2021

Hormonal-metabolic profile of blood serum of rats in 5 hours, on the first and third day after hyperthermia in water medium at the temperature of 45 °С till rectal temperature rose to 43.5 °С was studied. Hypercorticosteronaemia, hyperinsulinemia, hypoglycemia, hypocholesterolemia, hypotriglyceridaemia, hyperproteinemia and increase of protein metabolites level were revealed which was the evidence of hypermetabolism syndrome development during acute period after controlled hyperthermia.
Long-term coronary shunting results for 5 years of observation. Factors influencing on angina pectoris recurrence after coronary shunting
Authors: Seyidov V. G. , Fissun A. Ya. , Yevsyukov V. V. , Lyubchuk I. V. , Bobyrev S. Ye. , Arutyunov E. V.
Published: April 2021

Aimed at o comparing coronary shunting long-term results with drug treatment of angina pectoris as well as estimating influence of dyslipidemia, diabetes mellitus, hypoglycemic therapy nature, arterial hypertension and increased systemic inflammation on angina pectoris recurrence after the surgery, we examined 793 patients 5 years after coronary shunting and 81 patients who were treated by standard methods. Five years after the surgery, we noted decreased number of patients without angina pectoris symptoms and increased number of patients with angina pectoris. Increased levels of cholesterol, low density lipoproteins, α-lipoproteids, C-reactive proteins and diabetes mellitus of the 2-nd type II—III stage contribute to angina pectoris recurrence rate after the surgery. Operated on patients revealed angina pectoris recurrences, myocardial infarction frequency, repeated hospitalizations and annual mortality more seldom compared with patients who underwent drug treatment.
Diagnosis value of some acute-phase proteins in purulent-inflammatory diseases of uterine appendages
Authors: Shramko S. V. , Arkhipova S. V. , Bazhenova L. G. , Zorina R. M.
Published: April 2021

We investigated concentrations of acute-phase proteins a-2-macroglobulin (MG) and lactoferrin (LF) in blood serum of 78 women with various types of uterine appendages inflammatory processes. Coefficient MG/LF was used as an additional diagnostic criterum of purulent-necrotic destruction of organs and tissues and allowed us to choose proper treatment options. MG values were assessed by method of rocket immune electroforesis using monospecific antiserum to the given protein, LF level was assessed by enzyme linked immunoassay based method (ELISA). Standard was performed when coefficient MG/LF was greater than 1, and if value of coefficient MG/LF was less than 1, we performed surgical treatment. Using coefficient MG/LF as a diagnostic criterion of existence of organic destruction in uterine appendages allowed us to optimize the selection of treatment program.
Study of biologic cycles in chronic opisthorchiasis is of great practical importance. Electropuncture diagnosis based upon Foll`s method allows to study daily dynamics of functional activity of hepatobiliary system organs and to analyze received facts using spectral and сosine analysis. Analysis results revealed that patients with chronic opisthorchiasis maintain correlation stage between hepatobiliary and vegetative nervous system in the setting of overstrain of adaptive possibilities of the organism and correlation relation occurs between vegetative nervous system and biliferous system which is absent in healthy subjects
Authors: Levitsky Ye. F. , Poddoubnaya O. A. , Zamoschina T. A.
Published: April 2021

Изучение биоритмов при хроническом описторхозе имеет большое практическое значение. Электропунктурная диагностика по методу Фолля позволяет изучить суточную динамику функциональной активности органов гепатобилиарной системы и проанализировать полученные данные с использованием спектрального и косинор-анализа. Результаты показали, что у больных хроническим описторхозом на фоне перенапряжения адаптивных возможностей организма сохраняется степень корреляции между гепатобилиарной и вегетативной нервной системой и появляется корреляционная связь между вегетативной нервной системой и желчевыводящей системой, отсутствующая у здоровых лиц.
Method of treatment of post-necrotic cysts of pancreas
Authors: Morozov S. V. , Poluektov V. L. , Dolgikh V. T.
Published: April 2021

Aimed at obliteration, percutaneous punctures under control of ultrasound examination with inserting of 2—4 mg of cyclophosphan in 10—20 ml of 0,9% of NACl solution with exposure of 15 minutes were performed in 18 patients having postnecrotic cysts of pancreas. Mean size of the cysts was 12,6 mm. Obliteration of the cysts occurred in 10—14 days. Together with cytostatic action, e obliteration effect of cyclophosphan was due to its influence on exudation and proliferation processes unlike spirit and iodine. The method is more effective in non-formed cysts.
The role of opioid peptides in regulation of bile secretion in intact and isolated liver
Authors: Roudin I. V. , Medvedev M. A.
Published: April 2021

Influence of dalargin (non-selective mand d-аgonist), DADLE (selective) and DAGO (selective magonist) on the bile secretion frequency and cholates secretion was studied in acute experiments on isolated perfused liver of the white rats. Opioid peptides effects on isolated liver were revealed to mask by the higher levels of hierarchic regulation in intact liver.
Markers of a dermal barrier lipid structure in newborn children
Authors: Zhoukova O. A. , Balasheva I. I. , Nagayeva T. A. , Ogarkova L. G. , Nagaitsev A. V. , Filonenko N. N.
Published: April 2021

Study results of neutral lipids of superficial hydro-lipid film (SHLF) in healthy newborns ( n = 46), in the children with severe allergic history ( n = 29), in newborns with toxic erythema ( n = 34) and nappies dermatitis ( n = 29) are presented in the article. The study is performed using thin-layer chromatography. Marked changes in lipid structure of dermal SHLF in all children in comparison with controls are revealed which needs further observation and correction.
Molecular mechanisms of lymphocyte apoptosis injury in chronic viral infection
Authors: Zhoukova O. B.
Published: April 2021

Programmed cell death of lymphocytes in patients with chronic infections induced by tick-borne encephalitis, hepatites B and C was investigated. The injury character in realization of lymphocyte apoptosis is shown to depend on molecular features of the infectious agent. Apoptotic death of lymphocytes was elevated after their incubation in vitro with dexamethazone, etopozide and in the environment without serum. Receptor-dependent and mitochondrial paths of apoptotic signal conduction ways are preferably modulated in chronic virus persistence.
Effect of Lochein on liver metabolism under acute intoxication caused by the paracetamol and D-galactosamine
Authors: Sokolovskaya A. N.
Published: April 2021

Influence of original hepatoprotector lochein in comparison with influence of reference drug silimarin on metabolism of liver under acute intoxication caused in rats by the paracetamol or D -galactosamine was investigated in the given study. Lochein decreased more effective than silimarin manifestations of hepatotoxicity of paracetamol and D -galactosamine, contributed to recovery of basic functions of liver: it decreased blood activity of aminotranferases, alkaline and acid phosphatases, concentration of common bilirubin, activated its binding with glucuronic acid, brought protein and lipids to normal levels, prevented formation of products of lipid peroxidationproducts in the liver.
Ideas of ulcer disease patients concerning the disease causes and efficacy of its treatment methods
Authors: Vavilov A. M.
Published: April 2021

The aim of the study was to investigate ideas of ulcer disease patients concerning causes of the disease and efficacy of its treatment methods. The vast majority of patients consider the cause of peptic ulcers to be severe heredity, irregular eating, use of alcohol. The patients consider diet, eating regimen and intake of anthacides to be the most effective treatment methods of the disease.
Peculiarities of adaptation reactions in gestation hydremia and iron deficiency anemia in pregnant women
Authors: Mikheyenko G. A. , Ivanova O. A.
Published: April 2021

Adaptation level of pregnant women having iron deficiency anemia and gestation hydremia was studied using the analysis of white blood formula. It is proved that in gestation anemia, disadaptation can be seen most frequently at the first half of pregnancy and in the period of 29-32 weeks of gestation. In iron deficiency anemia, the most high strain of adaptation systems is recorded in the period of 20 to 32 weeks of pregnancy. It points to different directions of adaptive reactions in iron deficiency anemia and gestation hydremia, which are united by the decrease of hemoglobin level in pregnant women needs differentiation of correction of abovementioned states.
History of construction of faculty clinics of the Siberian State Medical University
Authors: Tetenev F. F. , Karzilov A. I.
Published: April 2021

Detailed information about the construction, architecture, and architects of faculty clinics of the Siberian State Medical University is presented.
Parameters of homocystein and features of the immune status in persons working in the chemical industry
Authors: Radzivil T. T. , Krat I. V. , Oradovskaya I. V.
Published: April 2021

The indices of the immune status and homocystein in persons working in the chemical industry are studied. As a result, the laboratory indications of activation of the immune system are revealed, as well as the increased activity of cellular and humoral immunity. Moderate homocysteinemia is found among men aging of 56—65 with an idiopathic hypertensia. Homocystein appears to be an independent risk factor of coronary, cerebral and peripheral vessels diseases.
Anatomy-morphological features of nasal mouth of ductus nasolacrimalis at pathological lacrimation
Authors: Tokareva N. S. , Shilov M. V. , Starokha A. V. , Logvinov S. V.
Published: April 2021

Optical endoscopy of nasal cavities and general histological and histochemical methods were used to reveal that the anatomically adverse variants of the structure of nasal mouth of ductus nasolacrimalis against a background of the chronic catarrhal inflammation of a mucous membrane of lacrimal passages with abnormality of the mucociliary clearance in patients with pathological lacrimation promote the development of dacryostenoses.
Posthumanity in variety of cultures. Globalization, bioethics, and civilization breaks — all only begins
Authors: Tulchinsky G. L.
Published: April 2021

The cultures boundaries in the hurtling world are going in accordance with the lines of civilization rents. The globalization flow trends are preparing the «posthuman» future. Presently we are at the take-off of the new civilization stage, what makes the de- bates of a human life in the frames of bioethics so much urgent.
Bioethics teaching difficultis (UNESCO discussion materials)
Authors: Apresian R. G. , Shamov I. A.
Published: April 2021

The experience of bioethics teaching in connection with UNESCO programs is discussed
The Ethics of Palliative Care and HIV/TB: Lessons from Tomsk, Siberia
Authors: Kelley M. . , Miller S. . , Solovieva S. A.
Published: April 2021

In 2006, Tomsk become an initial pilot site for a Globus Program initiative on palliative care, HIV and MTB. The paper pre- sents a discussion on the ethical aspects of palliative care and some lessons of the program «Adjusting Teamwork in Palliative Care», utilizing Tomsk Regional Center for AIDS and other Infectious Diseases.
To make a dream true? (Human engineering)
Authors: Yudin B. G.
Published: April 2021

Possible continuities of aftermath of human engineering wide use are taking under consideration. Emphasis is placed on the methodological reasons for interdisciplinary researches of the influence of biomedicine sledding on the human development and bi- oethical limitation of its usage. The research was supported by grant RHSF № 05-03-90306а.
The bioethics questions of the communication space management
Authors: Lukianova N. A. , Melik-Haikazyan M. V. , Tukhvatulina L. R.
Published: April 2021

The communication space as self-organization semiotic system was studied. This study was based on the information- synergetic approach model (I.V. Melik-Haikazjan). The limits of different communication models ordering were revealed, what al- lowed defining the structure of the communication space and the methods of its management.
Homo zwischens and the Choice problem
Authors: Matveyeva O. Yu.
Published: April 2021

This article is about Homo zwischens (from German "Between") they are doubting, varying people compelled in an atmosphere of uncertainty, when public structures are transformed make to the risky decision. The author proposes by means of information- synergetic (I.V. Melik-Haikazjan) approach to define the basic mechanisms of making — decision in this critical situation.
Morbidity analysis of socially important dermatoses and their clinical examination based upon results of questionnaire of conscripts in the Tomsk region
Authors: Pesterev P. N. , Khlynin S. M. , Podgornova Ye. S. , Perminov V. A.
Published: April 2021

Aimed at decreasing number of conscripts having allergic dermatoses, therapeutic measures were developed directed to stop-ping main pathologic manifestations of the disease which consequently leads to improved quality of life. Diseases of the skin were decreased in the Tomsk region from 6,6 to 6,1% based upon results of call-up campaigns in 2003-2005 years. Questionnaire of 150 persons in the call-up age was performed aimed at identification of main social and clinical factors which lead to the develop-ment of allergic dermatoses. Schemes of clinical observation given in the article allowed us to perform adequate observation of pa-tients with socially important dermatoses, to stop in time acute manifestations of the disease and to decrease number of patients with the given pathology in the structure of coscripts who received delays or liberations from military service
Efficacy assessment of main functions of drugstore organizations on Perm' drugstores example
Authors: Tretiyakova Ye. A.
Published: April 2021

Aimed at assessing financial result from commercial, production and social functions of drugstores, cost-functional and corre-lation-regressive analysis was performed. Accounts of Perm' drugstores were the object of the study. Mean profitability of trade function was established to be 13.1%, profitability of social function to be 4.3%, unprofitableness of production function to be 38.8%.
Results of complex social-hygienic investigation of life conditions, health status and medical activity of chemical industries' workers
Authors: Shternis T. A.
Published: April 2021

We asked 1187 workers of chemical fiber industry aimed at studying their health status, life conditionsmedical activity and taking measures directed to prevention of morbidity in the given social group. Data were taken from 2671 ambulance cards and 1284 cards of subjects undergoing medical examination.
Disturbed nourishing regimen was revealed in 54.9%, hypodynamia in 12.0%, distresses in 91.4% of workers. Prevalence of smoking was 44.9%, alcohol intake in 87.0%. Specific attitude to their health, medical aid, being informed about risk factors was revealed. Stable tendency to increased morbidity was revealed. Blood circulation diseases are on the 1-st place in the structure of to-tal morbidity.
Morbidity in chemical industry is due to labour conditions, absence of being interested in preserving their health. High mor-bidity is redoubled by unsatisfactory organizing and quality of medical -prevention service, bad material base. One should pay an attention to increasing results of medical-preventive service, labour conditions, health status, medical aid to the workers.
The respiratory system biomechanical homeostasis and its maintenance mechanisms in normal conditions and at obstructive pulmonary diseases
Authors: Karzilov A. I.
Published: April 2021

Parameters of breathing biomechanics in healthy persons (n = 20), patients with bronchial asthma (n = 30) and chronic obstruc-tive pulmonary disease (n = 30) are analyzed during electrical stimulation of the diaphragm. Methodology of homeostatic parame-ters searching and their classification is offered. Descriptive and comparative analyses are performed. Homeostatic parameters of biomechanics describing the condition of elastic and non -elastic properties of respiratory system, of respiratory muscles, of general pulmonary hysteresis, breathing regulation are differentiated. Basic homeostatic parameter is the ratio of inspiratory capacity to the lungs elastic recoil. The model of lungs with the biomechanical buffer and retractive-elastic- surfactant complex of lungs is offered. Biomechanical homeostasis idea of respiratory system as ability of an organism to support in dynamics balance normal and patho-logical conditions essentially important for preservation of respiratory system biomechanical parameters in admissible limits is for-mulated.
Оrganoprotective efficiency of eprosartan in patients with chronic glomerulonephritis
Authors: Kalyuzhina Ye. V. , Sourkova L. G. , Solovtsov M. A. , Konaplev D. I. , Kalyuzhin V. V.
Published: April 2021

The 12-week open uncontrollable study of eprosartan organoprotective efficacy was performed in 15 patients with chronic glomerulonephritis. Study results showed high organoprotective efficacy of eprosartan, prescribed in a dose of 600 mg daily, which is expressed as anti-proteinuric, anti-hematuric actions, positive dynamics of intraglomerular hemodynamics parameters, decreased left ventricular hypertrophy and stiffness and also normalized vasomotoric functions of brachial artery endothelium.
Retinoprotective effects of ascovertin under light influence in conditions of hyperglycemia
Authors: Logvinov S. V. , Plotnikov M. B. , Varakuta Ye. Yu. , Zhdankina A. A. , Potapov A. V. , Mikhulya Ye. P.
Published: April 2021

Experiments performed on white outbred 100 rats showed that light impact with the intensity of 6 000 lx y during 6 hours and radiation in the setting of alloxanic diabetes caused injury of most structural components of retina and significant microcirculatory disturbances in the sclera. Starting with 7 days after radiation, retina damages had focal character which was more evident during radiation in the setting of alloxanic diabetes. However, prolonged injection of ascovertin led to decreased decstruction and improved hemodynamics which was expressed in reliable decreasing focal area by 2.1 times after light impact and by 1.4 times after radiation in the setting of alloxanic diabetes.
High intense of the labour is a risk factor of stress-induced left ventricular hypertrophy in engine-drivers of locomotive engines in railway transport
Authors: Sorokin A. V. , Korovina O. V.
Published: April 2021

Prevalence of left ventricular hypertrophy in patients in dependence on blood pressure (BP) in professional groups of patients with high and low intense of job which is comparable with prevalence of risk factors ( smoking, hypertonic disease heredity, low physical activity, high body mass) and average levels of blood pressure is studied. The study included 853 males, working (engine-drivers and their assistants) with different levels of blood pressure (normal, high normal BP and hypertension). Controls were 330 males with lower intensity of labour. Higher (19%) prevalence of left ventricular hypertrophy was shown in engine -drivers with normal and high normal BP; prevalence in controls was 1,8 and 8,3% respectively. Patients with arterial hypertension revealed no such differences. Increased level of stress induced by high intense of labour is mediated by neurohumoral influences of stress hormones on myo-cardium. This can cause the development of left ventricular hypertrophy.
Hypoxic hypoxia as a haemostatic system-activating factor
Authors: Shakhmatov I. I. , Vdovin V. M. , Bondarchuk Yu. A. , Alekseyeva O. V. , Kiselyov V. I.
Published: April 2021

Aimed at investigating influence of hypoxic hypoxia of different duration on haemostatic system state, the assessment of coagulogram in 152 Vistar rats 1 and 3 hours after single «lifting» to the height of 5500 m over sea level in pressure chamber and after daily 3 hours during 7 and 30 days. Activating influence of single hypoxic xypoxia was on hemostasis was revealed. While in-creasing duration of single impact , activation hemostatic system increased and anticoagulant and fibrinolytic properties of blood plasma decreased. According to the coagulogram data, prethrombotic changes developed in the form of coagulation activation, thrombocytes intake, decreased anti-thrombin III level and fibrinolytic activity on the 7-th day of hypoxia. On the 30-th day, de-creased hemostatic activity with increasing anticoagulant plasma blood reserve and restorating fibrinolytic activity.