bluuebunny/crossref_metadata_2025 huggingface dataset:
Her Mesleğin Bir Dergisi Vardır Türkiye’de Bilgi ve Belge Yönetimi Alanında Yayın Faaliyeti Yürüten Dergiler
Authors: Keskin İshak , Güler Ceyhan , Sümbül Sinan
Published: July 2023

Dergi yayıncılığı, güncel bilginin fazla bir gecikme yaşanmaksızın ilgilileriyle paylaşılması anlamına gelmektedir. Bilimsel dergiler, ilk zamanlardan itibaren güncel bilimsel bilginin aktarılması, bilimin gelişmesi, yaygınlaşması ve bilim insanları arasında bilimsel iletişimi geliştirmek ve güçlendirmek için önemli bir işlev görmüştür. Makaleler nedeniyle yayına hazırlanmasının kısa süre alması, aynı cilt içinde birden fazla makalenin yayınlanabilmesi, farklı yazarların araştırmalarına yer verilmesi, bu makalelerin bir dergi formatında okurlarıyla buluşması, aynı yıl içinde birden çok kez cilt/sayı halinde basımının yapılması ve ilgililerine mümkün olan en hızlı bir şekilde ulaştırılması dergilerin tercih nedenleridir. Bu çalışmanın amacı; Türkiye’de bilgi ve belge yönetimi (BBY) alanında hazırlanan araştırmaları yayınlayan dergiler hakkında bilgi vermektir. Buna bağlı olarak çalışmada açıklanmaya çalışılan tek soru “Türkiye’de BBY alanında yayın faaliyeti yürüten hangi dergiler vardır?” şeklinde belirlenmiştir. Bu dergilerin hangi ad altında ve hangi yıldan itibaren, kaç cilt/sayı yayın yaptığı, düzenli yayın yapılıp-yapılmadığı, hakemli-hakemsiz oluşu, yayın amacı, hangi dil(ler)de yayın yaptığı, (e-)ISSN numarası alıp almadığı ve açık erişim durumu belirlenmeye çalışılmıştır. Araştırmada nitel araştırma yönteminden ve durum çalışmasından yararlanılmış olup, verilerin analizi için doküman analizi tekniğine başvurulmuştur. Çalışmanın verileri ise internet araştırması ve kütüphane taraması ile elde edilmiştir.
Magyar népmesekatalógus 1–9
Authors: Uther Hans-Jörg
Published: July 2023

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THE USE OF MACRO FUNCTION IN TENNESSE WILLIAMâ€™S DRAMA â€œA STREETCAR NAMED DESIREâ€ DISCOURSE ANALYSIS
Authors: Halil Citra Buana , Agnurhasta Azzan Wafiq
Published: July 2023

This article aims to know particular types of macro function and how its appear in the utterances on the drama. The writer uses purposive sampling technique to choose which sample were to be analyzed. The data were determined according to it needs and purpose of this research. The writer found some samples from this research. There are seventy samples which called hard sample. The result of this research is macro functions further divided into types but the writer only take five function namely: emotiveÂ (10), metalinguistic(13), directiveÂ (18), phaticÂ (6), and referentialÂ (2).Keywords: Macro Function, Drama, and DiscourseÂ Analysis
Investigation of the interactions of anticancer drugs with tyrosine kinase enzyme using semi-empirical methods and comparisons with DFT Calculations
Authors: İŞ Yusuf
Published: July 2023

In this work, the interaction energies of some commercial molecules that are still used clinically with aminoacids in the active region of the tyrosine kinase were calculated by semi-empirical methods such as AM1 and PM3. There are already some results calculated with DFT methods and published in an article previously. By comparing the results there with those found here, it has been discussed whether semi-empirical methods with much shorter computation times can be used to estimate the most critical aminoacids for the tyrosine kinase enzyme instead of DFT methods which take much more time. According to the results obtained here, in order for semi-empirical methods to be used instead of DFT methods for this purpose, the examined ligands must have an electrical charge in the physiological environment. In other words, the hypothesis put forward remains valid only if the ligand under consideration has a charge. The use of semi-empirical methods such as AM1 and PM3 instead of DFT methods to estimate the residues with which a molecule that does not have any electrical charge interacts most strongly did not yield overlapping results.
Quantum investigation of the reaction between triplet oxygen O(3P) atom and butadiene
Authors: MESSAOUDI Boulanouar , CHERIET Mouna , DJEMIL Rayenne , KHATMİ Djameleddine
Published: July 2023

We have explored the potential energy surface of the triplet oxygen atom O(3P) reaction with 1,3-butadiene at CBS-QB3 levels of theory. Possible different pathways have been determined to better understand the reaction mechanism. Thus, the first pathway of the oxidation of 1,3-butadiene by the triplet oxygen O(3P) is show that the major product is CH3-CO-CH=CH2. The results agree with those obtained experimentally in relative to the reaction enthalpies. The transition state theory (TST) was employed to compute rate constants over the temperature range 297-798K. The obtained results have shown that the electrophilic O-addition pathways on the double bond are dominant up in the temperature range. The activation energy is in line with the proposed addition mechanism.
Influence of electronic structure of (R)-4-menten-3-one on its restricted rotation and inversion
Authors: VAKULİN Ivan , LATYPOVA Elvira , FAATOVİCH Rifkat , ISHMURATOV Gumer Yusupovich , TALIPOVA Guzel Rafailovna
Published: July 2023

In this work we was study correlation between electronic structure of (R)-4-menthen-3-one and restricted transitions between its conformers. By NBO analysis, carried out in ab inition methods, we found special orbital interactions and sterical effects in conformers of (R)-4-menthen-3-one, which explained difficults of inversion and rotation.
Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein
Authors: EDACHE Emmanuel , UZAİRU Adamu , MAMZA Paul Andrew , SHALLANGWA Gideon Adamu
Published: July 2023

The propagation of emerging diseases and the expensive cost and time lost by using the classic methods, especially in the current scenario with the world being plagued by SARS-CoV-2 and Chlamydia trachomatis diseases, make finding another way to invent new medication very important. That's why we used computational approaches to predict protein-ligand interactions of thiazolino 2-pyridone amide derivatives. The high-throughput virtual screening requires extensive combing through existing datasets in the hope of finding possible matches to screen for new molecules able to inhibit SARS-CoV-2 and Chlamydia trachomatis diseases. In this study, 46 thiazolino-2-pyridone amide derivatives were chosen for planning the powerful inhibitors by utilizing various strategies: QSAR analysis, phylogenetic analysis, homology modeling, docking simulation, molecular dynamics (MD) simulation, as well as ADMET Screening. The 2D QSAR investigation uncovers that these compounds show a satisfactory connection with bioactivity. From that point onward, phylogenetic analysis and homology modeling were used to model the selected receptors, which were then evaluated using both the SAVES and PROSA servers, indicating the best correctness of the modeled protein with the experimental results. Additionally, a docking simulation investigation was carried out to comprehend the 46 thiazolino-2-pyridone amide derivatives' interactions with homologous proteins. Additionally, MD simulations coupled with MM/GBSA verified the chosen complex systems' stability over 1000 ps. Two compounds were chosen as possible inhibitors based on these findings. The expected thiazolino-2-pyridone amide's oral bioavailability and toxicity have been discovered under the ADMET. Thus, these discoveries can be leveraged to develop novel molecules with the necessary action.
Electronic Properties of Poly(N-vinylcarbazole) Using semi-empirical oligomer extrapolation approximations
Authors: NAZİB ALİAS Ahmad , MOHAMED ZABİDİ Zubainun , ALİ Ab Malik Marwan
Published: July 2023

Poly(N-vinylcarbazole) has been widely used in polymer light emitting diodes due to its unique electronic properties. The electronic properties of Poly(N-vinylcarbazole) were examined using the Semi-Empirical Zerner Modified Intermediate Neglect of Differential Overlap (ZINDO) oligomer extrapolation method. In this calculation, the electronic properties of Poly(N-vinylcarbazole) were extracted from oligomer electronic properties. We identified a tendency for oligomers with large HOMO-LUMO gaps in the form of linear regression as function of reciporocal of monomeric units. The increasing number of monomers induce the interaction between energy levels of each monomer which boardening the energy levels. The localized molecular orbital and vibration spectra of the basic unit of polymer Poly(N-vinylcarbazole) also has been investigated.
Dakwah dalam Pandangan Imam Khomeini (1902-1989 M)
Authors: Al Mukarromah
Published: July 2023

Ayatollah Ruhullah Al-Musawi Al-Khomeini or Imam Khomeini is one of the scholars in Iran as well as the leader of the Iranian state who took part in moving the Iranian people towards the teachings of Islam. The Iranian leader who was born in 1902 AD, through his work, was able to overthrow the ruling regime that wanted to distance the people from the teachings of Islam because of the influence of foreign intervention. Imam Khomeini was able to influence all the Iranian people to overthrow the anti-Islamic regime that was in office at that time, Shah Reza Pahlavi. With 98.2% of the people's vote in favor of the establishment of the Islamic Republic, officially on April 1, 1979 an Islamic Republic of Iran was established. This event is known as the Islamic Revolution of Iran. (Islamic, tt) This article can be used as a reference to find out how the da'wah and communication views of a leading figure from Iran, namely Imam Khomeini. The benefits of this research are a source of inspiration and add insight into the treasures of Islamic scholarship for Muslim scientists, da'wah and communication practitioners. This type of research is qualitative, namely descriptive research methods, namely historical descriptive namely describing historical research results using the "script study" method which uses analysis referring to library data, namely books, journals, and supporting historical documents that can support this research. Da'wahin Imam Khomeini's view is in line with the theory stated in the science of da'wah, the arguments of the Qur'an, and as-sunnah. In the science of da'wah there is an explanation of the elements of da'wah. Imam Khomeini has a da'wah view that almost all describes the components of the elements of da'wah, especially aspects regarding the da'i from the perspective of how the preacher's morals should be based on the concept of Islamic morals. Regarding mad'u, Imam Khomeini divides it into three based on their social strata, namely: officials, the public, and the rich, along with an explanation of the appropriate da'wah material for the distribution of the mad'u da'wah. Lastly, Methods of Effective Da'wah according to Imam Khomeini.
MUHAMMADIYAH MENGHADAPI PANDEMI COVID-19 DALAM PENDEKATAN PERKEMBANGAN TEKNOLOGI KOMUNIKASI
Authors: Mukhlish Muhammad Maududi
Published: July 2023

Komunikasi merupakan kebutuhan manusia dalam kehidupan, satu hal yang sangat fundamental, pola komunikasi manusia berubah seiring dengan lahirnya teknologi informasi dan komunikasi, pandemi covid-19 mendorong perubahan pemanfaatan teknologi menjadi lebih cepat, sebelum pandemi rapat-rapat dan dunia Pendidikan belum sepenuhnya menggunakan teknologi visual begitu datang pandemi pemanfaatan teknologi dengan plaffrom conferen dipergunakan, sehingga merubah dunia Pendidikan saat ini.   Tujuan penelitian ini adalah untuk mengetahui cara Muhammadiyah menghadapi pandemi covid-19 dalam pendekatan perkembangan teknologi komunikasi, dengan ini menggunakan metode kepustakaan, data diperoleh melalui penelusuran mesin pencari google dan google scholar. Hasil penelitian ini menunjukkan bahwa Muhammadiyah telah memanfaatkan teknologi komunikasi secara maksimalm banyak pengajian-pengajian yang dilakukan pengurus-pengurus Muhammadiyah menggunakan saran teknologi, hal yang menarik anggota Muhammadiya di ranting-ranting dapat mengikuti bahkan mengundang Pengurus Pusat Muhammadiyah untuk mengisi pengajian atau seminar-seminar hal yang sulit terjadi dimasa sebelum pandemic covid-19, dengan teknologi komunikasi bisa dioptimalkan untuk meningkatkan keimanan dan ketakwaan, konten-konten ilmu pengetahuan dapat diputar kapan saja dan dimana saja tidak perlu hadir dalam kelas-kelas.
PENGARUH BAHASA GAUL TERHADAP KOMUNIKASI BAHASA ANAK DI MASA PANDEMI
Authors: Nadifatul Ainiyah
Published: July 2023

Bahasa Indonesia merupakan bahasa Nasional yang digunakan untuk berkomunikasi. Namun adanya bahasa gaul dapat mengancam pergeseran penggunaan Bahasa Indonesia dengan baik dan benar. Dengan adanya masalah tersebut, maka penulis melakukan penelitian mengenai Pengaruh Bahasa Gaul Terhadap Bahasa Anak Dimasa Pandemi. Metode penelitian yang digunakan adalah metode deskriptif kualitatif yang dilakukan dengan studi literatur dan survey dari populasi 20 anak dan sampel 15 orang anak dan pengambilan data primer dengan teknik observasi tidak langsung. Hasil yang didapat berupa pencegahan dari pengaruh bahasa gaul terhadap bahasa anak dimasa pandemi. Dari hasil penelitian tersebut, penulis menarik kesimpulan bahwa anak-anak lebih sering menggunakan bahasa gaul daripada Bahasa Indonesia yang akan mengakibatkan terjadinya pergeseran bahasa dan terlupakannya Bahasa Indonesia.
Implementasi Pembelajaran Anak Slow Learner Pada Masa Pandemi di Sekolah Amanah Bunda Tangerang Selatan
Authors: Lisyafaati Hij Nabila.P  , Nur Dian Andini  , Rizkya Kamelida Fitriani
Published: July 2023

Education is one of the most important program that made by government. The government said the necessary things to put every child at school for at least 9 years. This rule includes normal and special needs kids. For the special needs child, the government provides a special system for the education called inclusive education. There are several kids categorized as a special needs child one of them is a slow learner. This slow learner child experiences obstacles or delays in thinking in several ways, responding to stimuli and adapting, but is better than mentally retarded, slower than normal. Slow learners in the classroom need longer study time than their peers. .the purpose of this study was to determine the teacher's efforts in guiding slow learner children. This research method uses qualitative methods by using a qualitative field approach and library research.
Strategi Guru Dalam Menangani Anak Yang Mengalami Keterlambatan Dalam Berbahasa (Observasi Lapangan Di TK Daarul Fattaah Tangerang)
Authors: Maratus Sholihah  , Maulida Fitriani  , Mia Istiqamah
Published: July 2023

The world health organization states that children aged 0-6 years are said to be in the golden age. This happens because the process of growth and development of children occurs rapidly in the span of development of human life. In this golden period, children learn by seeing, hearing, and feeling what is happening around them. In dealing with quiet children, as a teacher at school, special attention is needed, such as asking children to express their opinions more or trying to answer one or two questions that are telling a thing (experience) that makes children talk more and are no longer afraid to convey something. what he's been through. Speech disorders consist of problems with articulation, voice, fluency (stuttering), difficulty in using words, usually due to brain injury and delay in speaking. Children who have delays in speaking can be caused by various factors, one of which is environmental factors or hearing loss. Speech disorders are also closely related to other developments.
Implementasi Pembelajaran Guru Dalam Meningkatkan Perkembangan Bahasa Anak Di RA Al-Jihadiyah Bekasi
Authors: Anastasya Puspita  Hafidz  , Hafidz, Aulia Putri Pratiwi  , Mutiara
Published: July 2023

Research or observation is done to determine the indication of talk delay and handle children with a 4-6-year-old talk. This research is based on or based on our sense of our currency (author of children) of the child who exhausts the talk of the child and language of the child, especially at the age of 4-6 years. Talk and language disorders are one of the causes of growing children's growth that are often encountered. The methods undertaken by us are by interviewing the informant (teacher) directly at TK Ra al-Jihadiyah. The resourcesakenakers taken in this observation amounted to 2 informants with details 1 as Ra's headmaster, and the 2th is the teacher (educator) in RA itself. The results of our observations, there are several obstacles and how handling we have obtained: Language of disorders, difficulty understanding something, difficulties following clues or directives, a little communication, do not want to learn, parents are too demanding, and articulation or pronunciation. As for how to handle it, more attention from the parents and the teacher, intense communication in its environment is, and the language training by Mother to her son and teachers to the students.
PENERAPAN METODE TAMI OTAKA DALAM MENJAGA HAFALAN AL-QUR’AN JUZ 30 DI PAUD TAHFIZH PINTAR
Authors: Fikriyyah Hanifah  , Hasanah
Published: July 2023

Penelitian ini bertujuan untuk mengetahui dan menjelaskan tentang penerapan metode Tami Otaka dan faktor pendukung serta penghambat dalam metode Tami Otaka pada PAUD Tahfizh Pintar. Penelitian ini menggunakan metode observasi, wawancara, dan dokumentasi, serra menggunakan teknik analisis data yaitu reduksi data, penyajian data, dan penarikan kesimpulan,

Hasil penelitian ini menujukkan bahwa penerapan metode Tami Otaka di PAUD Tahfizh Pintar Joglo Jakarta Barat memiliki 3 tahapan yaitu persiapan pembelajaran, praktik pembelajaran, dan evaluasi pembelajaran metode Tami Otaka. Dalam menjaga hafalan Al-Qur’an yaitu dengan cara sering mendengarkan bacaan Al-Qur’an, membaca dalam shalat, selalu bersama dan berkumpul dengan hafiz Al-Qur’an, menggunakan satu mushaf, menjadi mustami (penyimak), dan sima’an Al-Qur’an. Adapun faktor pendukung dalam menggunakan metode Tami Otaka ialah salah satunya dengan adanya sumber belajar yang memadai yaitu buku khusus pembelajaran metode Tami Otaka, serta faktor penghambat dalam menggunakan metode Tami Otaka salah satunya ialah faktor lingkungan yang mempengaruhi rasa malas dan muraja’ah dalam menghafal.
Experience of introducing an electronic health records station in an objective structured clinical examination to evaluate medical students’ communication skills in Canada: a descriptive study
Authors: Chen Kuan-chin Jean , Bartman Ilona , Pugh Debra , Topps David , Desjardins Isabelle , Forgie Melissa , Archibald Douglas
Published: July 2023

Purpose: There is limited literature related to the assessment of electronic medical record (EMR)-related competencies. To address this gap, this study explored the feasibility of an EMR objective structured clinical examination (OSCE) station to evaluate medical students’ communication skills by psychometric analyses and standardized patients’ (SPs) perspectives on EMR use in an OSCE.Methods: An OSCE station that incorporated the use of an EMR was developed and pilot-tested in March 2020. Students’ communication skills were assessed by SPs and physician examiners. Students’ scores were compared between the EMR station and 9 other stations. A psychometric analysis, including item total correlation, was done. SPs participated in a post-OSCE focus group to discuss their perception of EMRs’ effect on communication.Results: Ninety-nine 3rd-year medical students participated in a 10-station OSCE that included the use of the EMR station. The EMR station had an acceptable item total correlation (0.217). Students who leveraged graphical displays in counseling received higher OSCE station scores from the SPs (P=0.041). The thematic analysis of SPs’ perceptions of students’ EMR use from the focus group revealed the following domains of themes: technology, communication, case design, ownership of health information, and timing of EMR usage.Conclusion: This study demonstrated the feasibility of incorporating EMR in assessing learner communication skills in an OSCE. The EMR station had acceptable psychometric characteristics. Some medical students were able to efficiently use the EMRs as an aid in patient counseling. Teaching students how to be patient-centered even in the presence of technology may promote engagement.
Chronic Obstructive Pulmonary Disease at the 2023 American Thoracic Society (ATS) International Conference
Authors: Mannino David
Published: July 2023

THE 2023 American Thoracic Society (ATS) international conference was held in Washington, D.C., USA, from May 20–24, 2023. The conference, which was nearly back to full strength after 3 years of the COVID-19 pandemic, had over 13,000 attendees, and featured over 200 sessions that dealt with chronic obstructive pulmonary disease (COPD) in some capacity. These sessions ranged from poster presentations to mini symposia to plenary sessions, and almost every other option available at the conference. Topics ranged from basic science and mechanisms to risk factors, epidemiology, and results of important clinical trials. This review will focus on some of the more impactful presentations at the meeting.
Apakah brand awareness mampu memoderasi promosi, kualitas produk dan inovasi terhadap keputusan pembelian?
Authors: Prastowo Sugeng Lubar , Rahmadi Rahmadi
Published: July 2023

Abstract. This study aims to examine whether brand awareness is able to moderate promotional activities, product quality and product innovation in increasing consumer purchasing decisions. The research was conducted at PT Jamus Baladewa Nusantara, the pioneering business of sofa product craftsmen. Quantitative research methods causal associative approach. Data collection was carried out using a questionnaire on 151 respondents, using a purposive sampling technique. Data analysis using the Smart PLS 3.0 program. The results of the study prove that the moderating variable of brand awareness is insufficient evidence to moderate promotional activities, product quality, and product innovation towards increasing consumer purchasing decisions. However, brand awareness has been proven to be significantly capable of acting as a predictor in increasing consumer purchasing decisions.The results of this study provide benefits in an effort to increase purchasing decisions, namely by increasing promotional activities, improving product quality, and enforcing brand awareness as a predictor.Keywords: Brand Awareness; Buying Decision; Innovation; Promotion; Product QualityÂ Abstrak. Penelitian ini bertujuan untuk mengkaji, apakah brand awareness mampu memoderasi aktifitas promosi, kualitas produk dan inovasi produk dalam meningkatkan keputusan pembelian konsumen. Penelitian dilakukan pada usaha rintisan pengrajin produk sofa PT Jamus Baladewa Nusantara. Metode penelitian kuantitatif pendekatan asosiatif kausal. Pengumpulan data dilakukan dengan kuesioner pada 151 responden, menggunakan teknik purposive sampling. Analisis data menggunakan program Smart PLS 3.0. Hasil penelitian membuktikan bahwa variabel moderasi brand awareness, tidak cukup bukti mampu memoderasi aktifitas promosi, kualitas produk, dan inovasi produk terhadap peningkatan keputusan pembelian konsumen. Namun brand awareness terbukti secara signifikan mampu berperan sebagai prediktor dalam meningkatkan keputusan pembelian konsumen. Hasil penelitian ini memberikan manfaat dalam upaya meningkatkan keputusan pembelian, yaitu dengan cara meningkatkan aktifitas promosi, meningkatkan kualitas produk, dan memberlakukan brand awareness sebagai prediktor.Kata kunci: Inovasi; Keputusan Pembelian; Kesadaran Merek; Kualitas Produk; Promosi
Roland Barthes, Fragments of a Lover's Discourse, Selected Fragments Translated by Timothy Mathews
Authors: Barthes Roland
Published: July 2023

Timothy Mathews proposes new translations of a selection of ‘figures’ of the discourse of love as originally proposed by Roland Barthes in the work Fragments d’un discours amoureux (1977).
After He Had Gone
Authors: Rendell Jane
Published: July 2023

When her father dies, his daughter turns to his books for comfort. She finds 13 volumes, favourite books, each one with a bookmark inserted. A friend tells her of Barthes’ Mourning Diary. The entries are short, phrases and fragments, often disconnected. The first entry was made on 26 October 1977, the day after his mother died, and the last on 15 September 1979. This two-year period saw Barthes writing and speaking in fragments and developing practices for their arrangement in books and albums. In A Lover’s Discourse: Fragments Barthes describes ‘these fragments of discourse’ as ‘figures,’ ( Barthes 1978 : 3), while in How to Live Together he talks of ‘presenting findings as we go along’ (2013: 133). Here, a daughter presents her own findings – fragments from Barthes and the books her father left behind – arranged as diary entries (from the day after Barthes’ mother’s death to the day after her own father’s death) according to the order of the 13 books she found after her father had gone.
PENGARUH KINERJA PERUSAHAAN TERHADAP NILAI PERUSAHAAN DENGAN KEBIJAKAN DIVIDEN SEBAGAI VARIABEL INTERVENING PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Subekti Heni , Musfiyana Risma , Kawuri Sri
Published: July 2023

Nilai perusahaan merupakan hal penting yang diperhatikan para investor sebelum mereka berinvestasi. Nilai perusahaan dapat memberikan kemakmuran pemegang saham secara maksimum apabila harga saham meningkat. Semakin tinggi harga saham sebuah perusahaan, maka makin tinggi kemakmuran pemegang saham. Penelitian ini bertujuan untuk mengetahui pengaruh likuiditas (Current Ratio), profitabilitas (ROE) dan leverage (DER) terhadap nilai perusahaan (PBV) dan mengetahui apakah kebijakan dividen (Dividen Payout Ratio) dapat dijadikan variabel intervening pada hubungan likuiditas (Current Ratio), profitabilitas(ROE)  dan leverage (DER) terhadap nilai perusahaan.

Populasi dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2015-2019. Sampel pada penelitian ini diambil dengan teknik Purposive Sampling yang berjumlah 12 perusahaan. Metode analisis data yang digunakan adalah analisis deskriptif dan analisis data menggunakan metode regresi linear berganda menggunakan software SPSS.

Hasil menunjukkan bahwa likuiditas (Current Ratio)  berpengaruh terhadap kebijakan dividen, sedangkan profitabilitas dan leverage tidak berpengaruh terhadap kebijakan dividen. Likuiditas (Current Ratio) dan leverage (DER) tidak berpengaruh terhadap nilai perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2015-2019. Sebaliknya profitabilitas dan kebijakan dividen mempunyai pengaruh dan signifikan terhadap nilai perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2015-2019. Sementara kebijakan deviden mampu memediasi hubungan antara likuiditas (Current Ratio)  dan nilai perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2015-2019. Demikian juga dengan hubungan leverage (DER) dan nilai perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia Tahun 2015-2019 mampu dimediasi oleh kebijakan dividen. Sebaliknya kebijakan dividen tidak dapat memediasi hubungan antara profitabilitas dengan nilai perusahaan.
Investigating chemoreception and behavioural responses of Tetranychus urticae (Trombidiformes: Tetranychidae) to organic acids, aldehydes and essential oil components
Authors: Gaudet Kayla , Faraone Nicoletta , Hillier Neil Kirk
Published: July 2023

The two-spotted spider mite, Tetranychus urticae Koch, is a globally distributed polyphagous agricultural pest that is resistant to a variety of synthetic chemical pesticides. Plant essential oils have been recognized as a novel natural source of pest control that have a reduced impact to the environment and human health relative to synthetic pesticides, and which may provide a viable alternative for managing this pest. The present study focuses on assessing the potential of mite semiochemicals and essential oil constitutes as repellents and miticides. We developed an innovative electrophysiological approach (electrotarsography) to record olfactory sensitivity of T. urticae. Additionally, a novel two-choice behavioural assay was designed to determine whether T. urticae is attracted or repelled by selected compounds. Using Gas Chromatography-linked Electrotarsal detection (GC-ETD), we determined that T. urticae can sense many terpenoids commonly found in plant essential oils, such as eucalyptol, thymol, and linalool. In addition, T. urticae responded to carboxylic acids and aldehydes, which are known to be detected by ionotropic receptors. In two-choice behavioural assays, T. urticae was repelled by various essential oil active ingredients, as well as carboxylic acids and aldehydes. The study provides much needed insight to identify behaviourally relevant chemical cues for the development of mite control strategies.
Advantage of precision metagenomics for urinary tract infection diagnostics
Authors: Almas Sadia , Carpenter Rob E. , Rowan Chase , Tamrakar Vaibhav K. , Bishop Joseph , Sharma Rahul
Published: July 2023

Background

Urinary tract infections (UTIs) remain a diagnostic challenge and often promote antibiotic overuse. Despite urine culture being the gold standard for UTI diagnosis, some uropathogens may lead to false-negative or inconclusive results. Although PCR testing is fast and highly sensitive, its diagnostic yield is limited to targeted microorganisms. Metagenomic next-generation sequencing (mNGS) is a hypothesis-free approach with potential of deciphering the urobiome. However, clinically relevant information is often buried in the enormous amount of sequencing data.

Methods

Precision metagenomics (PM) is a hybridization capture-based method with potential of enhanced discovery power and better diagnostic yield without diluting clinically relevant information. We collected 47 urine samples of clinically suspected UTI and in parallel tested each sample by microbial culture, PCR, and PM; then, we comparatively analyzed the results. Next, we phenotypically classified the cumulative microbial population using the Explify® data analysis platform for potential pathogenicity.

Results

Results revealed 100% positive predictive agreement (PPA) with culture results, which identified only 13 different microorganisms, compared to 19 and 62 organisms identified by PCR and PM, respectively. All identified organisms were classified into phenotypic groups (0–3) with increasing pathogenic potential and clinical relevance. This PM can simultaneously quantify and phenotypically classify the organisms readily through bioinformatic platforms like Explify®, essentially providing dissected and quantitative results for timely and accurate empiric UTI treatment.

Conclusion

PM offers potential for building effective diagnostic models beyond usual care testing in complex UTI diseases. Future studies should assess the impact of PM-guided UTI management on clinical outcomes.
Case report: Transcatheter tricuspid valve-in-valve implantation using novel balloon-expandable aortic valve with 1 year follow-up
Authors: Mussayev Abdurashid , Alimbayev Serik , Tanaliev Nursultan , Kuanyshbek Aidyn , Marat Aripov , Lesbekov Timur , Raissov Yerkezhan , Sadykova Aigerim , Kamila Askarovna Kenzhebayeva , Mukarov Murat , Pya Yuriy
Published: July 2023

Generally, the dysfunction or failure of bioprosthetic heart valves (BHVs) is managed by replacement surgery. In the case of tricuspid valve dysfunction, re-do surgery is rarely attempted because of the critically high risk of developing pulmonary hypertension, pulmonary embolism, and intraoperative mortality. Hence, transcatheter tricuspid repair and replacement procedures are preferred. More recently, transcatheter valve-in-valve (ViV) treatments have gained importance because of their less invasiveness, especially for patients with prior surgeries. Encouraging evidence of the safety and effectiveness of a novel balloon-expandable (BE) transcatheter heart valve (THV)—the Myval THV—has been reported for ViV procedures. Here, we present a case-series of 5 patients, in whom tricuspid ViV procedure was performed using BE Myval THV, implanted supra-annularly by anchoring onto the deteriorated BHV. This case-series details the procedural steps to prevent in-hospital adverse events and early (30-day) mortality and the challenges during tricuspid ViV interventions.
The absence of remotely triggered seismicity in Gujarat, NW India during the Nepal earthquake, 2015
Authors: Dixit Mayank , Bansal Abhey Ram
Published: July 2023

Gujarat in the Northwestern Deccan Volcanic Province of India is among the most seismically earthquake-prone. The region may be susceptible to remote dynamic triggering, especially the Kachchh region, which recently hosted the Mw7.7 Bhuj earthquake in 2001. Its aftershocks continue because it is critically stressed and contains nucleation points more frequently close to failure. From waveforms and catalog data, we examine whether remote dynamic triggering occurs following 25 April 2015, Mw7.8 Nepal mainshock in the Gujarat region, Northwestern India. The 2015 Nepal event perturbed the Gujarat region with a peak dynamic stress of ∼53 kPa, much higher than the global lower limit of 1 kPa. Due to the large magnitude and high peak dynamic stress, ideally, the 2015 mainshock should have resulted in the triggered seismicity in the study region. To study the remote dynamic triggering in detail, we also have examined the other recent regional large earthquakes with comparable peak dynamic stresses (>50 kPa), namely, 16 April 2013, Mw7.7 Iran, 24 September 2013, Mw7.7 Pakistan, and 26 October 2015, Mw7.7 Afghanistan. Our result shows that despite their significant peak dynamic stress, there is no significant change in the local seismicity. The analysis suggests that the surface wave amplitude is not the only factor that governs the remote dynamic triggering. Our results also indicate that the faults were not critically stressed during the mainshock candidates in the study region.
A probabilistic assessment of surface water-groundwater exchange flux at a PCE contaminated site using groundwater modelling
Authors: Benavides Höglund Nikolas , Sparrenbom Charlotte , Hugman Rui
Published: July 2023

Polluted groundwater discharge at a chlorinated solvent contaminated site in Hagfors, Sweden, is affecting a nearby stream flowing through a sparsely populated area. Because of difficulties related to source zone remediation, decision makers recently changed the short-term site management objective to mitigating discharge of polluted groundwater to the stream. To help formulating targeted remediation strategies pertaining to the new objective, we developed a groundwater numerical decision-support model. To facilitate reproducibility, the modelling workflow was scripted. The model was designed to quantify and reduce the uncertainty of surface water-groundwater (SW-GW) exchange fluxes for the studied period (2016–2020) through the use of history-matching. In addition to classical observations, thermal anomalies detected in fiber optic distributed temperature sensing (FO-DTS) measurements were used to inform the model of groundwater discharge. After assessing SW-GW exchange fluxes, we used measurements of surface water chemistry to provide a probabilistic estimation of mass influx and spatio-temporal distributions of contaminated groundwater discharge. Results show 1) SW-GW exchange fluxes are likely to be significantly larger than previously estimated, and 2) prior estimations of mass influx are located near the center of the posterior probability distribution. Based on this, we recommend decision makers to focus remediation action on specific segments of the stream.
Riparian vegetation response amid variable climate conditions across the Upper Gila River watershed: informing Tribal restoration priorities
Authors: Petrakis Roy E. , Norman Laura M. , Middleton Barry R.
Published: July 2023

Riparian systems across the Southwest United States are extremely valuable for the human and ecological communities that engage with them. However, they have experienced substantial changes and stresses over the past century, including non-native vegetation expansion, vegetation die-offs, and increased fire activity. Vegetation management approaches, such as ecological restoration, may address some of these stressors as well as reduce the risk of future impacts. We apply remote sensing to inform restoration priorities along the upper Gila River within the San Carlos Apache Reservation and Upper Gila River watershed. First, we develop a spatially and temporally explicit trend analysis across three observed climate periods (1985–1993, 1993–2014, 2014–2021) using the Landsat-derived indices to quantify changes in riparian vegetation conditions. These maps can be used to identify areas potentially more at risk for degradation. Second, we analyze changes in riparian vegetation within a climate framework to better understand trends and the potential effect of climate change. Vegetation greenness has largely increased throughout the watershed despite intensifying drought conditions across our study period, though areas within the lower watershed have shown increased stress and higher rates of wildfire and other disturbances over the past 5-years. Nevertheless, small-scale restoration activities appear to show improving vegetation conditions, suggesting efficacy of these restoration activities. Results from this study may be integrated with restoration objectives to develop a restoration plan that will help riparian vegetation communities adapt to change.
Heat pulse velocity method for determining water requirements in rainfed sweet cherry trees (Prunus avium L.)
Authors: Tharaga Phumudzo C. , Tesfuhuney Weldemichael A. , Coetzer Gesine M. , Savage Michael J.
Published: July 2023

It is imperative to possess a comprehensive understanding of the water consumption patterns of sweet cherry trees under rainfed conditions. This study investigates the water use of sweet cherry using the heat pulse velocity sap flow method. Tree response to drying soil conditions over two consecutive measurement periods (September 2017 to December 2018) in the eastern Free State, South Africa, is also evaluated. During the post-harvest period (December), there was a continuous increase in daily water consumption by trees, in conjunction with an increase in canopy cover, even though the crop load was reduced. Measured sap flow was positively correlated to net radiation, air temperature, and water vapour pressure deficit. The transpiration rates ranged from 1.2 to 3.5 L d-1 during the flowering stage (day of year, DOY, 244 – 270) and showed an increasing trend as the days progressed. During the ripening stage (DOY 271 – 292), transpiration rates decreased from 4.5 to 1.1 L d-1 over the 2018 season. This decreasing trend from the previous growth stage was due to soil drying and scorching weather conditions that led to trees experiencing water stress. Sap flow measurements, however, showed typical characteristics of the diurnal trend during selected days during varying weather conditions. The fraction of transpirable soil water (FTSW) threshold varied for different fruit growth stages and approached 1.0 for different stress levels. FTSW exceeded 0.4 when sweet cherry trees utilised stored soil water, while the transpiration rates declined during prolonged hot days. Moreover, the stress coefficient factor ranged between 0.45 – 0.65 for different growth stages. The daily soil water content varied, and soil evaporation was expected to increase during hot and dry days. In the early stage of a dry spell, soil water content did not directly affect the transpiration rate. Sweet cherry trees are susceptible to soil water deficit at different stages of fruit development. More research is required to understand transpiration as an irrigation management and planning indicator.
Analysis benefits of a second Allo-HSCT after CAR-T cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia who relapsed after transplant
Authors: Cao Xing-yu , Zhang Jian-ping , Zhao Yan-li , Xiong Min , Zhou Jia-rui , Lu Yue , Sun Rui-juan , Wei Zhi-jie , Liu De-yan , Zhang Xian , Yang Jun-fang , Lu Peihua
Published: July 2023

Background

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated high initial complete remission (CR) rates in B-cell acute lymphoblastic leukemia (B-ALL) patients, including those who relapsed after transplant. However, the duration of remission requires improvements. Whether bridging to a second allogeneic hematopoietic stem cell transplant (allo-HSCT) after CAR-T therapy can improve long-term survival remains controversial. We retrospectively analyzed long-term follow-up data of B-ALL patients who relapsed post-transplant and received CAR-T therapy followed by consolidation second allo-HSCT to investigate whether such a treatment sequence could improve long-term survival.

Methods

A single-center, retrospective study was performed between October 2017 and March 2022, involving 95 patients who received a consolidation second transplant after achieving CR from CAR-T therapy.

Results

The median age of patients was 22.8 years (range: 3.3-52.8) at the second transplant. After the first transplant, 71 patients (74.7%) experienced bone marrow relapse, 16 patients (16.8%) had extramedullary relapse, 5 patients (5.3%) had both bone marrow and extramedullary relapse and 3/95 patients (3.2%) had positive minimal residual disease (MRD) only. Patients received autologous (n=57, 60.0%) or allogeneic (n=28, 29.5%) CAR-T cells, while 10 patients (10.5%) were unknown. All patients achieved CR after CAR-T therapy. Before second HSCT, 86 patients (90.5%) were MRD-negative, and 9 (9.5%) were MRD-positive. All second transplant donors were different from the first transplant donors. The median follow-up time was 623 days (range: 33-1901) after the second HSCT. The 3-year overall survival (OS) and leukemia-free survival (LFS) were 55.3% (95%CI, 44.3-66.1%) and 49.8% (95%CI, 38.7-60.9%), respectively. The 3-year relapse incidence (RI) and non-relapse mortality (NRM) were 10.5% (95%CI, 5.6-19.6%) and 43.6% (95%CI, 33.9-56.2%), respectively. In multivariate analysis, the interval from CAR-T to second HSCT ≤90 days was associated with superior LFS(HR, 4.10, 95%CI,1.64-10.24; p=0.003) and OS(HR, 2.67, 95%CI, 1.24-5.74, p=0.012), as well as reduced NRM (HR, 2.45, 95%CI, 1.14-5.24, p=0.021).

Conclusions

Our study indicated that CAR-T therapy followed by consolidation second transplant could significantly improve long-term survival in B-ALL patients who relapsed post-transplant. The second transplant should be considered in suitable patients and is recommended to be performed within 90 days after CAR-T treatment.
Macrophage death in atherosclerosis: potential role in calcification
Authors: Neels Jaap G. , Gollentz Claire , Chinetti Giulia
Published: July 2023

Cell death is an important aspect of atherosclerotic plaque development. Insufficient efferocytosis of death cells by phagocytic macrophages leads to the buildup of a necrotic core that impacts stability of the plaque. Furthermore, in the presence of calcium and phosphate, apoptotic bodies resulting from death cells can act as nucleation sites for the formation of calcium phosphate crystals, mostly in the form of hydroxyapatite, which leads to calcification of the atherosclerotic plaque, further impacting plaque stability. Excessive uptake of cholesterol-loaded oxidized LDL particles by macrophages present in atherosclerotic plaques leads to foam cell formation, which not only reduces their efferocytosis capacity, but also can induce apoptosis in these cells. The resulting apoptotic bodies can contribute to calcification of the atherosclerotic plaque. Moreover, other forms of macrophage cell death, such as pyroptosis, necroptosis, parthanatos, and ferroptosis can also contribute by similar mechanisms to plaque calcification. This review focuses on macrophage death in atherosclerosis, and its potential role in calcification. Reducing macrophage cell death and/or increasing their efferocytosis capacity could be a novel therapeutic strategy to reduce the formation of a necrotic core and calcification and thereby improving atherosclerotic plaque stability.
Host-pathogen relationship in retreated tuberculosis with major rifampicin resistance–conferring mutations
Authors: Hang Nguyen Thi Le , Hijikata Minako , Maeda Shinji , Thuong Pham Huu , Huan Hoang Van , Hoang Nguyen Phuong , Tam Do Bang , Anh Pham Thu , Huyen Nguyen Thu , Cuong Vu Cao , Kobayashi Nobuyuki , Wakabayashi Keiko , Miyabayashi Akiko , Seto Shintaro , Keicho Naoto
Published: July 2023

Introduction

It is assumed that host defense systems eliminating the pathogen and regulating tissue damage make a strong impact on the outcome of tuberculosis (TB) disease and that these processes are affected by rifampicin (RIF) resistance–conferring mutations of Mycobacterium tuberculosis (Mtb). However, the host responses to the pathogen harboring different mutations have not been studied comprehensively in clinical settings. We analyzed clinico-epidemiological factors and blood transcriptomic signatures associated with major rpoB mutations conferring RIF resistance in a cohort study.

Methods

Demographic data were collected from 295 active pulmonary TB patients with treatment history in Hanoi, Vietnam. When recruited, drug resistance–conferring mutations and lineage-specific variations were identified using whole-genome sequencing of clinical Mtb isolates. Before starting retreatment, total RNA was extracted from the whole blood of HIV-negative patients infected with Mtb that carried either the rpoB H445Y or rpoB S450L mutation, and the total RNA was subjected to RNA sequencing after age-gender matching. The individual RNA expression levels in the blood sample set were also measured using real-time RT-PCR. Logistic and linear regression models were used to assess possible associations.

Results

In our cohort, rpoB S450L and rpoB H445Y were major RIF resistance–conferring mutations [32/87 (36.8%) and 15/87 (17.2%), respectively]. H445Y was enriched in the ancient Beijing genotype and was associated with nonsynonymous mutations of Rv1830 that has been reported to regulate antibiotic resilience. H445Y was also more frequently observed in genetically clustered strains and in samples from patients who had received more than one TB treatment episode. According to the RNA sequencing, gene sets involved in the interferon-γ and-α pathways were downregulated in H445Y compared with S450L. The qRT-PCR analysis also confirmed the low expression levels of interferon-inducible genes, including BATF2 and SERPING1, in the H445Y group, particularly in patients with extensive lesions on chest X-ray.

Discussion

Our study results showed that rpoB mutations as well as Mtb sublineage with additional genetic variants may have significant effects on host response. These findings strengthen the rationale for investigation of host-pathogen interactions to develop countermeasures against epidemics of drug-resistant TB.