bluuebunny/crossref_metadata_2025 huggingface dataset:
Overcoming the barriers of mobile health that hamper sustainability in low-resource environments
Authors: Greve Maike , Brendel Alfred Benedikt , van Osten Nils , Kolbe Lutz M.
Published: April 2021

Aim

This research aims to identify response strategies that non-profit organizations (NPOs) can apply to overcome the barriers that hamper the sustainable use of mobile health (mHealth) interventions in low-resource environments (LREs), such as in Sub-Saharan Africa (SSA).

Subject and method

A qualitative study on mHealth initiatives in SSA is conducted through semi-structured interviews with 15 key informants of NPOs that operate and manage mHealth interventions in this region. The interviews focus on identifying existing barriers and response strategies that NPOs apply to enable sustainable and long-term running interventions.

Results

Building on grounded theory techniques, the collected data guided us towards a process model that identifies four aggregated categories of challenging areas that require response strategies (economy, environment, technology, and user acceptance).

Conclusion

This study provides contributions from and implications for NPOs and researchers. Health practitioners are provided with a knowledge base of what barriers to expect and how to overcome them, to strive for sustainable implementation from the very beginning of an intervention. A process model is identified that structures the response strategies in a time-based agenda of mHealth initiatives and thus makes a theoretical contribution. Overall, this study addresses the need for a theoretical consideration of the “pilotitis” phenomenon, which currently hampers the sustainable implementation and scaling up of mHealth initiatives. While the focus is specifically on mHealth initiatives, the overall findings help prevent discontinuance of projects in the future after the pilot, and help facilitate LREs on their way to sustainable health interventions and universal health coverage.
Nutritional potential of underutilized edible plant species in coffee agroforestry systems of Yayu, southwestern Ethiopia
Authors: Aragaw Habtamu Seyoum , Nohr Donatus , Callo-Concha Daniel
Published: April 2021

Ethiopia is confronted with the paradox of hosting hundreds of edible plants and having high food and nutritional insecurity. Meals are mainly made up of staples and often lack of protein and micronutrients. Therefore, a large section of the population, particularly children and women, are malnourished. We hypothesize that wild edible plant species can contribute to fulfil the micronutrient demands of local people. Hence, we assessed the nutritional potential of underutilized edible plant species growing in understories of coffee agroforestry systems of southwestern Ethiopia. An ethnobotanical household survey (n = 300) documented the edible existing plants; and a promising subset of them (n = 12) was analysed for nutrient and antinutritional factor content in the lab. All 12 species, except fruits, have higher calcium, iron and zinc contents compared to regularly cultivated crops. Vitamin C was high in Syzygium guineense (330.72 mg/100 g edible parts or EP) and Rubus apetalus (294.19 mg/100 g). Beta-carotene ranged from 9.2 to 75 µg retinol activity equivalent (RAE) /100 g 25 among all species, but was exceptionally high in Rubus apetalus (161.7 µg RAE/100 g). Concerning the antinutritional factors, phytate content varied from 31.06 to 601.65 µg/100 g, being lower in Dioscorea prehensilis (31.06 µg/100 g) and D. alata (90.17 µg/100 g) compared to Carissa spinarum (601.65 µg/100 g) and Solanum nigrum (536.48 µg/100 g). Thus, we conclude that the assessed underutilized species are potential sources of dietary nutrients locally needed, and are notable Amaranthus graecizans, Portulaca oleracea and Dioscorea cayenensis as providers of Ca, Fe and Zn, and the fruit Rubus apetalus of provitamin A.
Economic assessment of the development of CO2 direct reduction technologies in long-term climate strategies of the Gulf countries
Authors: Babonneau Frédéric , Badran Ahmed , Benlahrech Maroua , Haurie Alain , Schenckery Maxime , Vielle Marc
Published: April 2021

This paper proposes an assessment of long-term climate strategies for oil- and gas-producing countries—in particular, the Gulf Cooperation Council (GCC) member states—as regards the Paris Agreement goal of limiting the increase of surface air temperature to 2°C by the end of the twenty-first century. The study evaluates the possible role of carbon dioxide removal (CDR) technologies under an international emissions trading market as a way to mitigate welfare losses. To model the strategic context, one assumes that a global cumulative emissions budget will have been allocated among different coalitions of countries—the GCC being one of them—and the existence of an international emissions trading market. A meta-game model is proposed in which deployment of CDR technologies as well as supply of emission rights are strategic variables and the payoffs are obtained from simulations of a general equilibrium model. The results of the simulations indicate that oil and gas producing countries and especially the GCC countries face a significant welfare loss risk, due to “unburnable oil” if a worldwide climate regime as recommended by the Paris Agreement is put in place. The development of CDR technologies, in particular direct air capture (DAC) alleviates somewhat this risk and offers these countries a new opportunity for exploiting their gas reserves and the carbon storage capacity offered by depleted oil and gas reservoirs.
Policy iteration for Hamilton–Jacobi–Bellman equations with control constraints
Authors: Kundu Sudeep , Kunisch Karl
Published: April 2021

Policy iteration is a widely used technique to solve the Hamilton Jacobi Bellman (HJB) equation, which arises from nonlinear optimal feedback control theory. Its convergence analysis has attracted much attention in the unconstrained case. Here we analyze the case with control constraints both for the HJB equations which arise in deterministic and in stochastic control cases. The linear equations in each iteration step are solved by an implicit upwind scheme. Numerical examples are conducted to solve the HJB equation with control constraints and comparisons are shown with the unconstrained cases.
ThamizhiMorph: A morphological parser for the Tamil language
Authors: Sarveswaran Kengatharaiyer , Dias Gihan , Butt Miriam
Published: April 2021

This paper presents an open source and extendable Morphological Analyser cum Generator (MAG) for Tamil named ThamizhiMorph. Tamil is a low-resource language in terms of NLP processing tools and applications. In addition, most of the available tools are neither open nor extendable. A morphological analyser is a key resource for the storage and retrieval of morphophonological and morphosyntactic information, especially for morphologically rich languages, and is also useful for developing applications within Machine Translation. This paper describes how ThamizhiMorph is designed using a Finite-State Transducer (FST) and implemented using Foma. We discuss our design decisions based on the peculiarities of Tamil and its nominal and verbal paradigms. We specify a high-level meta-language to efficiently characterise the language’s inflectional morphology. We evaluate ThamizhiMorph using text from a Tamil textbook and the Tamil Universal Dependency treebank version 2.5. The evaluation and error analysis attest a very high performance level, with the identified errors being mostly due to out-of-vocabulary items, which are easily fixable. In order to foster further development, we have made our scripts, the FST models, lexicons, Meta-Morphological rules, lists of generated verbs and nouns, and test data sets freely available for others to use and extend upon.
Spatiotemporal variation of nitrogen and phosphorus and its main influencing factors in Huangshui River basin
Authors: Dong Biqiong , Qin Tianling , Wang Yu , Zhao Yan , Liu Shanshan , Feng Jianming , Li Chenhao , Zhang Xin
Published: April 2021

The foundation of managing excess nutrients in river is the identification of key physical processes and the control of decisive influencing factors. The existing studies seldom consider the influence of rainfall-runoff relationship and only focus on a few anthropogenic activities and natural attributes factors. To address this issue, a comprehensive set of influencing factors including rainfall-runoff relationship (represented by runoff coefficient), basic physical and chemical parameters of water quality, land use types, landscape patterns, topography, and socioeconomic development was constructed in this study. M–K test and cluster analysis were conducted to identify the temporal mutation and spatial clustering characteristics of NH3-N and TP in Huangshui River basin, respectively. Partial least squares regression was used to elucidate the linkages between water contaminants and the factors. As shown in the results, the temporal mutations of NH3-N and TP were obvious in the middle reaches, with 4 out of 7 catchments in the middle reaches have a larger number of mutations of NH3-N than other catchments. The cluster analysis results of NH3-N and TP among catchments were similar. This study also indicated that although the Huangshui River basin was located in the upper reaches of the Yellow River, the influences of rainfall-runoff relationship on spatiotemporal changes of NH3-N and TP in its sub-basins were limited. Only the temporal change of NH3-N in Jintan catchment in the upstream area was significantly affected by runoff coefficient. The indexes of proportion of water area (PWA), proportion of impervious area (PIA), and proportion of primary industry (PPI) were the top three influencing factors of temporal variation of NH3-N and TP for most catchments in the middle reaches. The temporal change of NH3-N in Jintan catchment in the upstream area was obviously affected by runoff coefficient. The spatial variation of NH3-N and TP were all affected by PWA and proportion of secondary industry significantly. The results of this study can provide theoretical basis and technical support for the control and management of nitrogen and phosphorus pollution in upper reaches of rivers.
Cross-age peer tutoring in a technology-enhanced STEAM project at a lower secondary school
Authors: Tenhovirta Satu , Korhonen Tiina , Seitamaa-Hakkarainen Pirita , Hakkarainen Kai
Published: April 2021

The present investigation examined cross-age peer tutoring in the context of organising a technology-enhanced STEAM project aimed at bringing elements of maker culture to a lower secondary school. We examined how 8th graders tutored 7th graders in programming skills. The participants were peer tutors (n = 15) studying in a technology-oriented class, along with their teachers (5) and the researchers (2). By interviewing the tutors, we studied skills that the tutors had experienced as being essential to overcoming the challenges encountered. To trace the tutors’ social support network and the sharing of expertise, we asked the participants to draw a personal social network map. Three key tutors were identified, whose centrality in the network was socially validated by the number of peer tutors seeking their advice. Two case studies of key tutors’ learning networks were carried out. The findings revealed that the tutors needed versatile technological, social, pedagogical, and reflective know-how in the project. It is concluded that cross-age peer tutoring provides significant support for implementing practices of making and STEAM education at school.
Differential Object Marking in Kazakh: The Dynamic Syntax Approach
Authors: Christopher Nadezda
Published: April 2021

This paper presents a novel, Dynamic Syntax-based approach to the phenomenon of differential object marking in Kazakh, which can be extended at least to other Turkic languages displaying this phenomenon. It is demonstrated that the difference in the pragmatics associated with marked and unmarked direct objects, as well as the syntactic restrictions on the positioning of unmarked direct objects, can be elegantly and succinctly explicated through the application of the notions of fixed and unfixed nodes, without the need for proposing special syntactic positions or additional pragmatics for the accusative case.
Electrodeposition of palladium-dotted nickel nanowire networks as a robust self-supported methanol electrooxidation catalyst
Authors: Boettcher Tim , Stojkovikj Sasho , Khadke Prashant , Kunz Ulrike , Mayer Matthew T. , Roth Christina , Ensinger Wolfang , Muench Falk
Published: April 2021

Mass activity and long-term stability are two major issues in current fuel cell catalyst designs. While supported catalysts normally suffer from poor long-term stability but show high mass activity, unsupported catalysts tend to perform better in the first point while showing deficits in the latter one. In this study, a facile synthesis route towards self-supported metallic electrocatalyst nanoarchitectures with both aspects in mind is outlined. This procedure consists of a palladium seeding step of ion track-etched polymer templates followed by a nickel electrodeposition and template dissolution. With this strategy, free-standing nickel nanowire networks which contain palladium nanoparticles only in their outer surface are obtained. These networks are tested in anodic half-cell measurements for demonstrating their capability of oxidising methanol in alkaline electrolytes. The results from the electrochemical experiments show that this new catalyst is more tolerant towards high methanol concentrations (up to $${5}\,\hbox{mol}\,\hbox{L}^{-1}$$

5

mol

L

-
1

) than a commercial carbon supported palladium nanoparticle catalyst and provides a much better long-term stability during potential cycling.

Graphical Abstract
Understanding the farm data lifecycle: collection, use, and impact of farm data on U.S. commercial corn and soybean farms
Authors: Thompson Nathanael M. , DeLay Nathan D. , Mintert James R.
Published: April 2021

Enthusiasm regarding the “digital agriculture” revolution is widespread, yet objective research on how commercial farms actually use data and data services remains limited. The purpose of this research is to better understand the current positioning of U.S. commercial corn and soybean farms within the farm data lifecycle, including the collection, use, and impact of farm data. Using survey data from a sample of 800 commercial-scale U.S. corn and soybean farms, the factors associated with progression within the farm data lifecycle are examined. Results indicate that the majority of commercial U.S. corn and soybean farms collect data, indicate that the data they collect influences their decisions, and perceive positive yield benefits as a result of their data-informed decisions. However, farms vary in intensity of their data usage. Investments in data management and analysis resources are associated with progression within the farm data lifecycle. These investments comprise software products that manage and analyze data, including creating GPS maps, layering different data sources, and generating recommendations. Investments in human capital, either in on-farm employees with designated data responsibilities or in trusted off-farm service providers, are also associated with progression within the farm data lifecycle. Farms that have not yet invested in these types of data management and data analysis resources may be forfeiting the potential benefits associated with using their farm’s data to improve on-farm decision making.
Recollecting the Religious: Augustine in Answer to Meno’s Paradox
Authors: Haecker Ryan , Moulin-Stożek Daniel
Published: April 2021

Philosophers of education often view the role of religion in education with suspicion, claiming it to be impossible, indoctrinatory or controversial unless reduced to secular premises and aims. The ‘post-secular’ and ‘decolonial’ turns of the new millennium have, however, afforded opportunities to revaluate this predilection. In a social and intellectual context where the arguments of previous generations of philosophers may be challenged on account of positivist assumptions, there may be an opening for the reconsideration of alternative but traditional religious epistemologies. In this article, we pursue one such line of thought by revisiting a classic question in the philosophy of education, Meno’s Paradox of inquiry. We do this to revitalise understanding and justification for religious education. Our argument is not altogether new, but in our view, is in need of restatement: liturgy is at the heart of education and it is so because it is a locus of knowledge. We make this argument by exploring St Augustine’s response to Meno’s Paradox, and his radical claim that only Christ can be called ‘teacher’. Though ancient, this view of the relationship of the teacher and student to knowledge may seem surprisingly contemporary because of its emphasis on the independence of the learner. Although our argument is grounded in classic texts of the Western tradition, we suggest that arguments could be made by drawing on similar resources in other religious traditions, such as Islam, that also draw upon the Platonic tradition and similarly emphasise the importance of communal and personal acts of worship.
Home Energy Efficiency and Subjective Health in Greater London
Authors: Symonds P. , Verschoor N. , Chalabi Z. , Taylor J. , Davies M.
Published: April 2021

The UK has introduced legislation that requires net-zero greenhouse gas emissions to be achieved by 2050. Improving the energy efficiency of homes is a key objective to help reach this target, and the UK government’s Clean Growth Strategy aims to get many homes up to an Energy Performance Certificate (EPC) Band of C by 2035. The relationship between home energy-efficiency and occupant health and wellbeing remains an area of ongoing research. This paper explores the nexus between home energy efficiency, energy consumption and self-reported health—an indicator of the general health and wellbeing of the population. We focus on Greater London through secondary data analysis. Energy-efficiency ratings and air infiltration rates of dwellings, derived from EPCs, were aggregated and matched to local area self-reported health and energy consumption data obtained from the Greater London Authority’s (GLA) Lower Layer Super Output Area (LSOA) Atlas database. Our regression model indicates that improving the energy efficiency (SAP) rating by 10 points for a typical home may reduce household gas consumption by around 7% (95% CIs: 2%, 14%). Beta regression finds a positive, but not statistically significant association between median SAP rating and the proportion of the population reporting ‘good or very good’ health when considering all Greater London LSOAs (z score = 0.60, p value = 0.55). A statistically significant positive association is observed however when repeating the analysis for the lowest income quartile LSOAs (z score = 2.03, p value = 0.04). This indicates that the least well-off may benefit most from home energy efficiency programs. A statistically significant positive association is also observed for the relationship between self-reported health and air infiltration rates (z score = 2.62, p value = 0.01). The findings support existing evidence for the predominantly naturally ventilated UK housing stock, suggesting that home energy efficiency measures provide a co-benefit for occupant health provided that adequate air exchange is maintained.
Impact of N on the Stacking Fault Energy and Phase Stability of FCC CrMnFeCoNi: An Ab Initio Study
Authors: Ikeda Yuji , Körmann Fritz
Published: April 2021

Interstitial alloying has become an important pillar in tuning and improving the materials properties of high-entropy alloys, e.g., enabling interstitial solid-solution hardening and for tuning the stacking fault energies. In this work we performed ab initio calculations to evaluate the impact of interstitial alloying with nitrogen on the fcc–hcp phase stability for the prototypical CrMnFeCoNi alloy. The N solution energies are broadly distributed and reveal a clear correlation with the local environments. We show that N addition stabilizes the fcc phase of CrMnFeCoNi and increases the stacking fault energy.
Incremental Net Monetary Benefit of Bariatric Surgery: Systematic Review and Meta-Analysis of Cost-Effectiveness Evidences
Authors: Noparatayaporn Prapaporn , Thavorncharoensap Montarat , Chaikledkaew Usa , Bagepally Bhavani Shankara , Thakkinstian Ammarin
Published: April 2021

This systematic review aimed to comprehensively synthesize cost-effectiveness evidences of bariatric surgery by pooling incremental net monetary benefits (INB). Twenty-eight full economic evaluation studies comparing bariatric surgery with usual care were identified from five databases. In high-income countries (HICs), bariatric surgery was cost-effective among mixed obesity group (i.e., obesity with/without diabetes) over a 10-year time horizon (pooled INB = $53,063.69; 95% CI $42,647.96, $63,479.43) and lifetime horizon (pooled INB = $101,897.96; 95% CI $79,390.93, $124,404.99). All studies conducted among obese with diabetes reported that bariatric surgery was cost-effective. Also, the pooled INB for obesity with diabetes group over lifetime horizon in HICs was $80,826.28 (95% CI $32,500.75, $129,151.81). Nevertheless, no evidence is available in low- and middle-income countries.

Graphical abstract
The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy
Authors: Kvarik Timea , Reglodi Dora , Werling Dora , Vaczy Alexandra , Kovari Petra , Szabo Edina , Kovacs Krisztina , Hashimoto Hitoshi , Ertl Tibor , Gyarmati Judit , Atlasz Tamas
Published: April 2021

Pituitary adenylate cyclase–activating polypeptide (PACAP) is a neuropeptide having trophic and protective functions in neural tissues, including the retina. Previously, we have shown that intravitreal PACAP administration can maintain retinal structure in the animal model of retinopathy of prematurity (ROP). The purpose of this study is to examine the development of ROP in PACAP-deficient and wild-type mice to reveal the function of endogenous PACAP. Wild-type and PACAP-knockout (KO) mouse pups at postnatal day (PD) 7 were maintained at 75% oxygen for 5 consecutive days then returned to room air on PD12 to develop oxygen-induced retinopathy (OIR). On PD15, animals underwent electroretinography (ERG) to assess visual function. On PD16, eyes were harvested for either immunohistochemistry to determine the percentage of the central avascular retinal area or molecular analysis to assess angiogenesis proteins by array kit and anti-apoptotic protein kinase B (Akt) change by western blot. Retinas of PACAP-deficient OIR mice showed a greater central avascular area than that of the wild types. ERG revealed significantly decreased b-wave amplitude in PACAP KO compared to their controls. Several angiogenic proteins were upregulated due to OIR, and 11 different proteins markedly increased in PACAP-deficient mice, whereas western blot analysis revealed a reduction in Akt phosphorylation, suggesting an advanced cell death in the lack of PACAP. This is the first study to examine the endogenous effect of PACAP in the OIR model. Previously, we have shown the beneficial effect of exogenous local PACAP treatment in the rat OIR model. Together with the present findings, we suggest that PACAP could be a novel retinoprotective agent in ROP.
How Plausible Is the Implausible? Students’ Plausibility and Prevalence Ratings of the Self-Report Symptom Inventory
Authors: Boskovic Irena , Merten Thomas , Merckelbach Harald
Published: April 2021

Some self-report symptom validity tests, such as the Self-Report Symptom Inventory (SRSI), rely on a detection strategy that uses bizarre, extreme, or very rare symptoms. Thus, items are constructed to invite respondents with an invalid response style to affirm pseudosymptoms that are usually not experienced by genuine patients. However, these pseudosymptoms should not be easily recognizable, because otherwise sophisticated over-reporters could strategically avoid them and go undetected. Therefore, we tested how well future psychology professionals were able to differentiate between genuine complaints and pseudosymptoms in terms of their plausibility and prevalence.

Psychology students (N = 87) received the items of the SRSI online and were given the task to rate each item as to its plausibility and prevalence in the community.

Students evaluated genuine symptoms as significantly more plausible and more prevalent than pseudosymptoms. However, 56% of students rated pseudosymptoms as moderately plausible, whereas 17% rated them as moderately prevalent in the general public.

Overall, it appears that psychology students are successful in distinguishing bizarre, unusual, or rare symptoms from genuine complaints. Yet, the majority of students still attributed relatively high prima facie plausibility to pseudosymptoms. We contend that if such a trusting attitude is true for psychology students, it may also be the case for young psychology practitioners, which, consequently, may diminish the probability of employing self-report validity measures in psychological assessments.
Neurofilament Light Chain Is a Biomarker of Neurodegeneration in Ataxia Telangiectasia
Authors: Donath H. , Woelke S. , Schubert R. , Kieslich M. , Theis M. , Auburger G. , Duecker R. P. , Zielen S.
Published: April 2021

Ataxia telangiectasia (A-T) is a progressive and life-limiting disease associated with cerebellar ataxia due to progressive cerebellar degeneration. In addition to ataxia, which is described in detail, the presence of chorea, dystonia, oculomotor apraxia, athetosis, parkinsonism, and myoclonia are typical manifestations of the disease. The study aimed to evaluate the specificity and sensitivity of neurofilament light chain (NfL) as a biomarker of neurodegeneration in relation to SARA score. In this prospective trial, one visit of 42 A-T patients aged 1.3–25.6 years (mean 11.6 ± 7.3 years) was performed, in which NfL was determined from serum by ELISA. Additionally, a neurological examination of the patients was performed. Blood was collected from 19 healthy volunteers ≥ 12 years of age. We found significantly increased levels of NfL in patients with A-T compared to healthy controls (21.5 ± 3.6 pg/mL vs. 9.3 ± 0.49 pg/mL, p ≤ 0.01). There was a significant correlation of NfL with age, AFP, and SARA. NfL is a new potential progression biomarker in blood for neurodegeneration in A-T which increases with age.
A serial optical frequency-domain imaging study of early and late vascular responses to bioresorbable-polymer sirolimus-eluting stents for the treatment of acute myocardial infarction and stable coronary artery disease patients: results of the MECHANISM-ULTIMASTER study
Authors: Itoh Tomonori , Otake Hiromasa , Kimura Takumi , Tsukiyama Yoshiro , Kikuchi Tatsuo , Okubo Munenori , Hayashi Takatoshi , Okamura Takayuki , Kuramitsu Shoichi , Morita Takashi , Sonoda Shinjo , Ishihara Shozo , Kuriyama Nehiro , Isshiki Takaaki , Soeda Tsunenari , Hibi Kiyoshi , Shinke Toshiro , Morino Yoshihiro ,   the MECHANISM-ULTIMASTER study group, Shimoda Yudai , Inoue Takumi , Okura Hiroyuki , Takenaka Takashi , Sakakibara Masaki , Jinno Yasushi , Yasaka Yoshinori , Takaya Tomofumi , Shite Junya , Kozuki Amane , Kadotani Makoto , Kaetsu Yasuhiro , Tsutsui Yoshitomo , Mochizuki Mamoru , Masuda Naoki , Tanabe Kengo , Tanabe Kengo , Ishii Hideki , Otsuka Yoritaka , Abe Mitsuru
Published: April 2021

The purpose of this study was to assess early and late vascular healing in response to bioresorbable-polymer sirolimus-eluting stents (BP-SESs) for the treatment of patients with ST-elevation myocardial infarction (STEMI) and stable coronary artery disease (CAD). A total of 106 patients with STEMI and 101 patients with stable-CAD were enrolled. Optical frequency-domain images were acquired at baseline, at 1- or 3-month follow-up, and at 12-month follow-up. In the STEMI and CAD cohorts, the percentage of uncovered struts (%US) was significantly and remarkably decreased during early two points and at 12-month (the STEMI cohort: 1-month: 18.75 ± 0.78%, 3-month: 10.19 ± 0.77%, 12-month: 1.80 ± 0.72%; p < 0.001, the CAD cohort: 1-month: 9.44 ± 0.78%, 3-month: 7.78 ± 0.78%, 12-month: 1.07 ± 0.73%; p < 0.001 respectively). The average peri-strut low-intensity area (PLIA) score in the STEMI cohort was significantly decreased during follow-up period (1.90 ± 1.14, 1.18 ± 1.25, and 1.01 ± 0.72; p ≤ 0.001), whereas the one in the CAD cohort was not significantly changed (0.89 ± 1.24, 0.67 ± 1.07, and 0.64 ± 0.72; p = 0.59). In comparison with both groups, differences of %US and PLIA score at early two points were almost disappeared or close at 12 months. The strut-coverage and healing processes in the early phase after BP-SES implantation were significantly improved in both cohorts, especially markedly in STEMI patients. At 1 year, qualitatively and quantitatively consistent neointimal coverage was achieved in both pathogenetic groups.
Assessment of heavy metals contamination and associated risks in shallow groundwater sources from three different residential areas within Ibadan metropolis, southwest Nigeria
Authors: Ganiyu Saheed Adekunle , Oyadeyi Abimbola Temitope , Adeyemi Azeem Adedeji
Published: April 2021

This study has been conducted to appraise the concentrations of selected heavy metals and total dissolved solids (TDSs) in the drinking water from shallow wells in parts of Ibadan metropolis, southwest Nigeria. Fifteen (15) water samples were collected from three representative residential locations [traditional core area (TCA), peri-urban area (PUA), and urban area (UA)] for geochemical analysis. Heavy metals and TDS were analyzed with the aid of atomic absorption spectrophotometer and calibrated meter, respectively. The mean concentration (mg/L) of Zn, Pb Mn, Fe, and Cd has been 3.930, 0.658, 0.0304, 1.698, and 0.501, respectively, and as a consequence, the order of abundance of studied metals was Zn > Fe > Pb > Cd > Mn. Concentrations of Zn, Fe, Pb, and Cd were higher than recommended standards in 60%, 86.7%, 100%, and 100% of groundwater samples, respectively. However, at all points tested, the mean concentrations of Mn and TDS in water samples lie within the safe limits set by World Health Organization. The evaluation of geoaccumulation index (Igeo), enrichment factor (EF), and contamination factor suggests that representative water samples were low-to-moderate contamination. The potential ecological risk index advocates low-to-moderate ecological risk in TCA and PUA, while it demonstrated exclusive “moderate” risk in UA. Further, the range of pollution load index (PLI) (0.55–1.32) in both TCA and PUA shows nil-to-moderate pollution status, while PLI values > 1 in UA indicate moderate contaminated state. The degree of contamination in groundwater showed the following trends: UA > TCA > PUA in the study area. Moreover, the results of EF and quantification of contamination of analyzed metals in water samples indicate geogenic and anthropogenic inputs. The contribution of studied metals to the incidence of non-cancer risk via oral intake within the residential sites follows the order: cadmium > lead > zinc > iron > manganese. The hazard index as a result of ingested heavy metals for the three population classes surpasses the acceptable range in the order of infant < child < adult. Cadmium and lead made considerable impact to the estimation of cancer risk in the study area for the three human population categories. Factor analysis extracted only one component that explained 94.64% of the entire variance, while cluster analysis identified three distinct groups based on similar water quality characteristics. Based on the findings of the study, awareness programs toward protecting the shallow groundwater sources should be launched, encouraged, and sustained. Moreover, the study suggests better hygienic practices and pre-treatment of contaminated water before consumption.
To Conscience First, and to the Pope (Long) Afterwards? British Catholics and their Attitudes towards Morality and Structural Issues concerning the Catholic Church
Authors: Clements Ben , Bullivant Stephen
Published: April 2021

Background

The attitudes of Catholics in Britain have undergone significant liberalisation on social moral issues across recent decades, whilst the reputation of the Catholic Church has suffered due to public opposition to its traditional teachings on such issues. But there has been comparatively little recent investigation into British Catholics’ views on these debates using surveys aimed at this religious community.

Purpose

This article examines the sources of attitudinal heterogeneity amongst Catholics in Britain on core debates affecting the Catholic Church. The aims are to examine, firstly, which groups within the British Catholic Community are more likely to conform to or to dissent from the Church's teachings and, secondly, whether the socio-demographic and religious correlates of attitudes vary across different types of issue.

Methods

This article uses a new, nationally representative survey of Catholic adults in Britain (n = 1823). The survey is used to examine the sources of variation in Catholics’ attitudes towards a range of issues relating to the Roman Catholic Church. These issues relate to the priesthood, personal morality, and sinful behaviours. OLS models are used to assesses the relative impact of socio-demographic, religious socialisation, and religious commitment variables.

Results

The findings show that women are consistently more liberal in their views than men. Greater religious commitment is always associated with support for the traditional teachings of the Church.

Conclusions and Implications

Exploring the sources of attitudinal heterogeneity among Catholics, we provide new insights into the internal dynamics of ‘Britain's largest minority’. We conclude by discussing the potential effects of increasing ‘nonversion’ for interpreting religious statistics—a topic of relevance beyond the denominational and geographical confines of this study's explicit focus.
Tribological behavior of co-textured cylinder liner-piston ring during running-in
Authors: Miao Chenwei , Guo Zhiwei , Yuan Chengqing
Published: April 2021

The running-in of cylinder liner-piston rings (CLPRs) is the most important process that must be performed before a marine diesel engine can be operated. The quality of running-in directly affects the reliability of a CLPR. The surface texture of a CLPR has been proven to significantly affect its lubrication performance. In this study, the tribological behavior of a CLPR during running-in is investigated. Three types of surface textures are generated on the CLPR via laser processing: dimple texture on piston rings, groove texture on cylinder liners, and co-texture on both sides. Subsequently, a series of tests are performed on a slice tester. A load of 300 N (1.64 MPa) is applied, and two speeds (50 and 100 rpm) are adopted. The CLPR running-in quality is characterized based on three parameters, i.e., the friction coefficient, contact resistance, and wear topography. Experimental results show that, compared with a non-textured surface, the three types of surface textures mentioned above improved the friction performance during running-in. The lubricant supply capacity of the dimple texture on the piston ring, as a mobile oil reservoir, is stronger than that of the groove texture on the cylinder liner serving as a static oil reservoir. By contrast, the wear resistance of the dimple texture, as a movable debris trap on the piston ring, is weaker than that of the groove texture on the cylinder liner, which serves as a static debris trap. It is demonstrated that the co-texture combines the advantages of dimples and groove textures. Compared with non-textured surfaces, the friction coefficient decreased the most at 100 rpm (44.5%), and the contact resistance improved the most at 50 rpm (352.9%). The coupling effect provides the surface with improved running-in quality by optimizing the tribological performance, particularly at the dead center. This study provides guidance for the tribological design and manufacturing of CLPR in marine diesel engines.
A design of experiment approach to 3D-printed mouthpieces sound analysis
Authors: Bacciaglia Antonio , Ceruti Alessandro , Liverani Alfredo
Published: April 2021

Nowadays additive manufacturing is affected by a rapid expansion of possible applications. It is defined as a set of technologies that allow the production of components from 3D digital models in a short time by adding material layer by layer. It shows enormous potential to support wind musical instruments manufacturing because the design of complex shapes could produce unexplored and unconventional sounds, together with external customization capabilities. The change in the production process, material and shape could affect the resulting sound. This work aims to compare the music performances of 3D-printed trombone mouthpieces using both Fused Deposition Modelling and Stereolithography techniques, compared to the commercial brass one. The quantitative comparison is made applying a Design of Experiment methodology, to detect the main additive manufacturing parameters that affect the sound quality. Digital audio processing techniques, such as spectral analysis, cross-correlation and psychoacoustic analysis in terms of loudness, roughness and fluctuation strength have been applied to evaluate sounds. The methodology herein applied could be used as a standard for future studies on additively manufactured musical instruments.
A recommendation system for scientific water data
Authors: Xue Zhaokun , Couch Alva
Published: April 2021

We describe a recommendation system for HydroShare, a platform for scientific water data sharing. We discuss similarities, differences and challenges for implementing recommendation systems for scientific water data sharing. We discuss and analyze the behaviors that scientists exhibit in using HydroShare as documented by users’ activity logs. Unlike entertainment system users, users on HydroShare tend to be task-oriented, where the set of tasks of interest can change over time, and older interests are sometimes no longer relevant. By validating recommendation approaches against user behavior as expressed in activity logs, we conclude that a combination of content-based filtering and a latent Dirichlet allocation (LDA) topic modeling of user behavior—rather than and instead of LDA classification of dataset topics—provides a workable solution for HydroShare and compares this approach to existing recommendation methods.
The Seesaw of Seasonal Precipitation Variability Between North China and the Southwest United States: A Response to Arctic Amplification
Authors: Dai Haijin , Zhao Jun , Yao Qiang , Zhang Xueyan
Published: April 2021

Surface albedo over the ice‐covered polar ocean is decreased in a highly idealized numerical experiment, which leads to stronger (weaker) warming at high (low) latitudes, and forms Arctic amplification. With stronger warming at both high and low latitudes, the meridional temperature gradient decreases (increases) at midlatitudes (subtropical regions). A cyclonic wind anomaly appears and results in a weak Kuroshio current and warm interdecadal Pacific Oscillation phase. In response to Arctic‐amplified‐warming, the subtropical high weakens, leading to summer monsoon anomaly on its southside and increased westward transport of water vapor, resulting in a seesaw pattern: dry (wet) conditions in summer in North China (southwest United States, SWUS). In winter, the East Asian trough (North American high) decreases and induces decreased (increased) cold air transport to North China (SWUS) in response to Arctic‐amplified‐warming, which makes rain unlikely (likely) and exhibits a seesaw pattern. Moisture convergence always appears in a warmer SWUS winter, and increases precipitation there, which strengthens (counteracts) the precipitation anomaly led by the North American high in a warm (cold) interdecadal Pacific Oscillation phase. It may even shut down the seesaw pattern in winter in the cold interdecadal Pacific Oscillation phase.
Different Sensitivities of Earthquake‐Induced Water Level and Hydrogeological Property Variations in Two Aquifer Systems
Authors: Zhang Hui , Shi Zheming , Wang Guangcai , Yan Xin , Liu Chenglong , Sun Xiaolong , Ma Yuchuan , Wen Dongguang
Published: April 2021

Determining the factors that control the sensitivity of aquifer responses to earthquakes may provide insight into the interaction between hydrogeological and tectonic processes in the shallow crustal zone. Such response sensitivity varies randomly at the spatial scale and its determining factors have not been evaluated quantitatively and are still under debate. In this paper, we analyze seismically induced water level changes and then infer aquifer permeability changes following multiple earthquakes in two long‐term groundwater‐monitoring wells. While earthquake‐related water level changes were observed in one well, the second was insensitive to seismic events. These different seismic responses provide a unique opportunity to identify factors that control earthquake‐related changes. Wavelet transform, coupled with water level responses to tidal forcing, provides a methodology for comparing pre‐ and post‐seismic responses to periodic behavior. These methods found aquifer hydrogeological properties (e.g., transmissivity, storativity, degree of confinement) to be functions of their local hydrogeologic and tectonic settings. Key factors that may affect hydrogeological responses include the seismic energy arriving around the well, the degree of aquifer confinement, and the well location relative to local faults. Such factors favor seismic shaking and fracture unclogging, thus determining the sensitivity of hydrogeological responses to earthquakes. These findings are useful for designing wells for monitoring earthquakes, understanding earthquake‐inducing mechanisms, evaluating underground waste repositories, and estimating hydrogeological parameters using inversion.
DNA tetrahedron-mediated immune-sandwich assay for rapid and sensitive detection of PSA through a microfluidic electrochemical detection system
Authors: Feng Dezhi , Su Jing , Xu Yi , He Guifang , Wang Chenguang , Wang Xiao , Pan Tingrui , Ding Xianting , Mi Xianqiang
Published: April 2021

Prostate-specific antigen (PSA) is the most widely used biomarker for the early diagnosis of prostate cancer. Existing methods for PSA detection are burdened with some limitations and require improvement. Herein, we developed a novel microfluidic–electrochemical (μFEC) detection system for PSA detection. First, we constructed an electrochemical biosensor based on screen-printed electrodes (SPEs) with modification of gold nanoflowers (Au NFs) and DNA tetrahedron structural probes (TSPs), which showed great detection performance. Second, we fabricated microfluidic chips by DNA TSP-Au NF-modified SPEs and a PDMS layer with designed dense meandering microchannels. Finally, the μFEC detection system was achieved based on microfluidic chips integrated with the liquid automatic conveying unit and electrochemical detection platform. The μFEC system we developed acquired great detection performance for PSA detection in PBS solution. For PSA assays in spiked serum samples of the μFEC system, we obtained a linear dynamic range of 1–100 ng/mL with a limit of detection of 0.2 ng/mL and a total reaction time <25 min. Real serum samples of prostate cancer patients presented a strong correlation between the “gold-standard” chemiluminescence assays and the μFEC system. In terms of operation procedure, cost, and reaction time, our method was superior to the current methods for PSA detection and shows great potential for practical clinical application in the future.
Variation in fur properties may explain differences in heat-related mortality among Australian flying-foxes
Authors: Ratnayake Himali Udeshinie , Welbergen Justin Arno , van der Ree Rodney , Kearney Michael Ray
Published: April 2021

Fur properties play a critical role in the thermoregulation of mammals and are becoming of particular interest as the frequency, intensity, and duration of extreme heat events are increasing under climate change. Australian flying-foxes are known to experience mass die-offs during extreme heat events, yet little is known about how different fur properties affect their thermoregulatory needs. In this study, we examined the differences and patterns in fur properties among and within the four mainland Australian flying-fox species: Pteropus poliocephalus, P. alecto, P. conspicillatus, and P. scapulatus. Using museum specimens, we collected data on fur solar reflectance, fur length and fur depth from the four species across their distribution. We found that P. poliocephalus had significantly longer and deeper fur, and P. alecto had significantly lower fur solar reflectivity, compared with the other species. Across all species, juveniles had deeper fur than adults, and females of P. alecto and P. conspicillatus had deeper fur than males. The biophysical effects of these fur properties are complex and contingent on the degree of exposure to solar radiation, but they may help to explain the relatively higher mortality of P. alecto and of juveniles and females that is commonly observed during extreme heat events.
Two distinct subsets of LDGs (low density granulocytes) in ANCA-associated vasculitis
Authors: Endo Akiko , Komagata Yoshinori , Yamagishi Konomi , Kawashima Soko , Arimura Yoshihiro , Kaname Shinya
Published: April 2021

Objectives and methods

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disorder that causes vasculitis in small blood vessels throughout the body. Low-density granulocytes (LDGs) in autoimmune diseases, such as SLE and AAV, might play a critical role in the pathogenesis of these diseases. Here, we aimed to determine the characteristics of LDGs in patients with AAV. We assessed the number of whole white blood cells, neutrophil extracellular traps (NETs) productivity, proportion of cell surface markers (e.g. CD10), responses to immunosuppressants, and proteomics of LDGs in patients with AAV.

Results

We found more LDGs in peripheral blood mononuclear cells (PBMCs) of patients with AAV than PBMCs of healthy controls (HCs) and confirmed that these LDGs in AAV produced more NETs than normal density granulocytes (NDGs) in HCs. We identified CD10-positive LDGs with mature neutrophil features and CD10-negative LDGs with immature granulocyte properties; the proportion of the two LDG types decreased and increased, respectively, in the patients during treatment. Proteomic analysis revealed that the two LDG groups shared protein expression that differed from those of NDGs.

Conclusion

We identified distinct CD10-positive and CD10-negative LDGs in patients with AAV. The roles of these LDGs in AAV pathology will require further investigation.