bluuebunny/crossref_metadata_2025 huggingface dataset:
On Vascular Lesions of the Thyroid Gland with Emphasis on Intrathyroidal Hemangioma: Clinicopathologic Characterization of Two Cases and Review of the Literature
Authors: MacDonald William W. , Wakely Paul E. , Argyris Prokopios P.
Published: October 2024

Mesenchymal neoplasms of the thyroid gland are exceptionally rare accounting for less than 0.5% of all intrathyroidal tumors with hemangiomas comprising merely 6% of them. The clinicopathologic characteristics of two additional examples of thyroid hemangioma together with a thorough review of the pertinent literature are presented. A 62-year-old man and an 18-year-old woman presented with asymptomatic, soft-to-palpation, mobile nodules of the right thyroid lobe classified as TI-RADS 5 and TI-RADS 4, respectively, on ultrasound imaging. Microscopically, lesions featured a circumscribed, unencapsulated, lobular proliferation of variably-sized, congested, vascular channels lined by a single layer of flattened, cytologically bland endothelial cells, together with interspersed residual follicles. Vascular endothelial cells were strongly positive for CD31, CD34 and ERG, and negative for pancytokeratin AE1/AE3, TTF1, and PAX8. A diagnosis of cavernous hemangioma was rendered in the clinical setting of Hashimoto thyroiditis and follicular adenoma, respectively. Following inclusion of the current cases, a total of 53 intrathyroidal hemangiomas were identified in the literature with a patient mean age of 48.9 years (range = 0.17-84) and a slight female predilection (F:M = 1.4:1). A proclivity for the right thyroid lobe (59.6%) was noted with the striking majority of cases exhibiting features of cavernous hemangioma (95.2%). Prognosis is favorable and surgical resection is considered curative. The occasionally alarming clinical presentation in conjunction with absence of pathognomonic imaging features and limited diagnostic accuracy of FNA cytopathology for such lesions renders surgical intervention necessary for definitive diagnosis of intrathyroidal hemangiomas and exclusion of other epithelial and non-epithelial pathologic entities.
Wonderboom, South Africa: An Acheulean workshop with evidence of flake harvesting
Authors: Lotter Matt G. , Lombard Marlize , Caruana Matthew V.
Published: October 2024

There are several characteristics that can be used to identify Acheulean workshops. However, the direct flaking of raw-material outcrops can be an important step in Acheulean lithic production that is missing from the current trait list. Here, we define and introduce the first systematically documented evidence of what we refer to as ‘flake harvesting’ at Wonderboom in Gauteng, South Africa. The presence of flakes and cores from the excavated Acheulean deposit, with similar dimensions and in similar condition to those associated with the nearby flake-harvesting localities, indicate that the behaviour was associated with the Acheulean. We explain that collecting flakes in this manner is different from quarrying, and provide a recording protocol that can be applied to other localities. This could help to explore whether the behaviour has been missed previously, or whether it is a uniquely localised development. We provide a summary of Acheulean workshop traits reported by other researchers, demonstrating that several of these traits are present at Wonderboom, so that the site can now be thought of in terms of a workshop, amongst other things, and flake harvesting can be added to the list.
Importance and variability of the paternal component in sow reproductive traits
Authors: Cieleń G. , Sell-Kubiak E.
Published: October 2024

Reproductive traits are an integral part of the goals of the breeding programs that contribute to the economic success of production. Reproductive phenotypes such as litter size, number of piglets born alive, or litter weight at birth are mainly attributed to females. Thus, the maternal components can be found by default in quantitative genetics’ animal models. Still, paternal contribution to variance components should not be discarded. In this review, we indicate the importance of paternal effects in pig breeding by describing both the biology and genetics of boars’ traits, the use of (non-)genetic service sire effects in quantitative genetic models for traits measured on females, and genes involved in male reproduction. We start by describing the important biological traits of boars that have the most important effect on their reproductive abilities, i.e., sexual maturity, sperm quality, and testes parameters. Then we move to the possible environmental effects that could affect those traits of boars (e.g., feed, temperature). The main part of the review in detail describes the genetics of boars’ reproductive traits (i.e., heritability) and their direct effect on reproductive traits of females (i.e., genetic correlations). We then move to the use of both genetic and non-genetic service sire effects in quantitative models estimated as their percentage in the total variance of traits, which vary depending on the breed from 1 to 4.5% or from 1 to 2%, respectively. Finally, we focus on the description of candidate genes and confirmed mutations affecting male reproduction success: IGF2, Tgm8, ESR1, ZSWIM7, and ELMO1. In conclusion, the observed variance of paternal effects in female reproduction traits might come from various attributes of boars including biological and genetic aspects. Those attributes of boars should not be neglected as they contribute to the success of female reproductive traits.
Upregulation of microRNAs correlates with downregulation of HERV-K expression in Parkinson’s disease
Authors: Simula Elena Rita , Jasemi Somaye , Paulus Kay , Sechi Leonardo Antonio
Published: October 2024

Human endogenous retroviruses (HERVs) involvement in neurological diseases has been extensively documented, although the etiology of HERV reactivation remains unclear. MicroRNAs represent one of the potential regulatory mechanisms of HERV reactivation. We identified fourteen microRNAs predicted to bind the HERV-K transcript, and subsequently analyzed for their gene expression levels alongside those of HERV-K. We documented an increased expression of four microRNAs in patients with Parkinson’s disease compared to healthy controls, which correlated with a downregulation of HERV-K transcripts. We hypothesize that specific microRNAs may bind to HERV-K transcripts, leading to its downregulation.
Impact of Nano-TiO2 Combination with Biodiesel on Diesel Engine Performance and Emissions Under Fuel Magnetism Conditioning
Authors: El-Fakharany M. K. , Abdelrazek Ahmed S. , Baz Faisal B. , Gad M. S.
Published: October 2024

Problems of atomization, spray, and lower output power are due to the biodiesel’s higher viscosity. All of these aim to encourage fuel magnetism and nanoparticles addition to reduce fuel consumption. Waste cooking oil was converted to methyl ester by transesterification. To make methyl ester blend, diesel and biodiesel were mixed at volume ratio of 20%. TiO2 nanoparticles were added to biodiesel blend B20 at doses of 25 and 50 mg/L. TEM and XRD were used to characterize the nanomaterials. A magnetic coil was placed before the fuel injector to apply a magnetic field on the line of fuel. South pole of the magnetic field is located near to the fuel line, whereas the north pole is located further away. To examine the impact of these nanomaterials with fuel magnetism on engine performance and emissions using WCO biodiesel mixture, an experimental test rig was built connected to diesel engine. During testing, diesel engine operates at 1500 rpm with load variation. The average increases in BTE were 1, 1.5, 3.5, 5.5, and 6.5% but the decreases in BSFC were 1.2, 2, 4, 5, and 6% for B20 + magnet, B20 + 25 TiO2, B20 + 25 TiO2 + magnet, B20 + 50 TiO2, and B20 + 50 TiO2 + magnet, respectively, at engine load range. The average drops in CO, NOx, and HC concentrations were 16, 22, and 33%, respectively, at load range for B20 + 50 TiO2 + magnet. To improve engine performance and reduce emissions, biodiesel blend B20 from waste cooking oil with nanoTiO2 concentration of 50 ppm under magnetic field effect was recommended as a substitute fuel in diesel engine.
Valorization of Different Clays Used in the Treatment of Oily Wastewater in the Development of Construction Products
Authors: Ayadi Chaima , Alouani Rabah , Nahdi Kais , Eliche-Quesada Dolores
Published: October 2024

The aim of this research is to study the feasibility of using clays used in the decontamination of wastewater containing olive oil wastewater (OOW), new lubricating oil (NOW) or motor oil (MOW) in the manufacture of ceramic bricks. Three types of clays were used for filtration, kaolinite type clay (KT), smectite type clay (CT) both from Tunisia and illitic chloritic clay (CS) from Jaén (Spain). These clays containing different types of oils, as well as the control clays, were used in the manufacture of bricks fired at 900 °C. These bricks were characterized by physical, mechanical and thermal tests. The sintered microstructure’s evolution was followed by tracked through scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD). The results indicate that the specific type of clay used influences the technological characteristics of the bricks. The use of CT clay gives rise to increase bulk density, greater compressive strength, and reduced apparent porosity and water absorption. The use of clays used in the decontamination of water containing oils produced a decrease in bulk density, compressive strength and thermal conductivity and leads to an increase in apparent porosity and water absorption in the order OOW > NOW > MOW according to the total organic carbon content (TOC). Therefore, the use of clays used in the filtration of water that contain different oils can represent a promising way of valorizing this waste, which can alleviate the environmental impact and represents economic savings for the industry of construction materials with properties of thermal insulation, getting closer to a circular economy.
Comparative assessment of autoclave- and microwave-facilitated seawater pretreatments for the enhancement of sugar recovery from banana pseudostem
Authors: Hute Thandi , Sanusi Isaac A. , Kana Evariste B. Gueguim , Meyer Edson L. , Sewsynker-Sukai Yeshona
Published: October 2024

This study evaluated the efficacy of optimized autoclave-assisted seawater (A-SW) and microwave-assisted seawater (M-SW) pretreatments in improving sugar production from banana pseudostem. Subsequently, the structural changes of banana pseudostem, along with inhibitory compound concentrations were assessed under the conditions optimized for A-SW and M-SW pretreatment models. High coefficient of determination (R2) value (> 0.82) was obtained for both A-SW and M-SW. In addition, comparable reducing sugar of 0.41 ± 0.01 g/g and glucose yield of 0.24 ± 0.001 g/g were obtained from the optimized A-SW pretreatment, compared with the reducing sugar yield of 0.23 ± 0.004 g/g and glucose yield of 0.14 ± 002 g/g from the optimized M-SW regime. Furthermore, the A-SW high pretreatment efficiency was confirmed by changes in the biomass structure and low concentration of inhibitory compounds. Therefore, the potential use of abundant and sustainable seawater-based in this study with different heating mechanisms for pretreatment of lignocellulosic biomass provides a novel strategy to reduce the costs associated with the application of chemicals and scarce fresh water in lignocellulosic biorefineries.
The Interplay of Racism, Climate, and the Environment on Child and Adolescent Health: Implications for Pediatricians
Authors: Miles Aida , Sathyanarayana Sheela , Walker-Harding Leslie , Simpson Joelle N. , Smith Katy , Coyne-Beasley Tamera
Published: October 2024

Purpose of Review

We highlight the disparate effects of climate change and unhealthy environments on children and youth and suggest pragmatic steps for pediatricians to address the harms both inside and outside the clinic space.

Recent Findings

Environment and climate can inflict long-term, multi-faceted harms on children. As trusted resources by families and policy makers, pediatricians have a unique role in addressing these harms.

Environmental toxins and climate change pose significant threats to the health and well-being of children and adolescents. There are inequities in how these threats are distributed in communities, resulting in many disparities. Pediatricians must prioritize addressing climate and environmental threats out of duty to their patients and as a matter of environmental justice. This can be done through research, advocacy, working with policymakers, and supporting youth in their advocacy and preparedness efforts, as well as through patient screening and clinical care.
Rethinking security: the resilience of shallow ML models
Authors: Teixeira Rafael , Antunes Mário , Barraca João Paulo , Gomes Diogo , Aguiar Rui L.
Published: October 2024

The current growth of machine learning (ML) enabled the commercialization of several applications, such as data analytics, autonomous systems, and security diagnostics. These models are becoming pervasive in most systems and are deployed into every possible domain. Hand in hand with this growth are security and privacy issues. Although such issues are being actively researched, there is an evident fragmentation in the analysis and definition of the ML models’ resilience. This work explores the resilience of shallow ML models to a relevant attack of data poisoning, as poisoning data attacks pose serious threats, compromising ML model integrity and performance. Our study aimed to uncover the strengths of shallow ML models when facing adversarial manipulation. Evaluations were performed in a CAPTCHA scenario using the well-known MINIST dataset. Results indicate remarkable resilience, maintaining accuracy and generalization despite malicious inputs. Understanding the mechanisms enabling resilience can aid in fortifying future ML systems’ security. Further research is needed to explore limits and develop effective countermeasures against sophisticated poisoning attacks.
A Comparative Analysis of Parent–Child Interaction Therapy Procedures Used to Facilitate Verbalizations by Children with Autism
Authors: Barnes Ross Megan , Stokes Trevor F.
Published: October 2024

The current study conducted a comparative analysis of the effects of select components of Parent–Child Interaction Therapy, labeled praise, behavior descriptions, and reflections on child vocalizations in two children with autism spectrum disorder and accompanying language delays using a concurrent multiple baseline across participants design. The frequency of verbalizations, the frequency of different verbalizations, and the mean length of utterance of words (MLUw) were measured during a baseline condition followed sequentially by two experimental conditions during a free play environment. The total number of therapist–child interactions remained consistent across all experimental conditions such that only the topography of the interactions varied across conditions. During the first experimental condition the clinician used labeled praise and behavior descriptions during child play. After establishing stability of changes under these conditions, the therapist systematically added reflections of child vocalizations in the second experimental condition. Total verbalizations, different verbalizations, and MLUw increased following the introduction of labeled praise and behavior descriptions. Total verbalizations and different verbalizations increased and the frequencies accelerated following the systematic introduction of reflections. The study showed the relative value of reflections of child verbalizations as a powerful component of Parent–Child Interaction Therapy procedures to facilitate verbalizations by children with autism.
CT and MRI of pancreatic cystic lesions: tricks of the trade
Authors: Vetro Vincenzo , Agnello Francesco , Raitano Elisa , Calsi Simona Li , Pinzone Sabrina , Galia Massimo
Published: October 2024

Purpose

To describe CT and MRI findings of pancreatic cystic lesions.

Background

The growing use of ultrasound, CT and MRI has led to increasing incidental detection of pancreatic cystic lesions. These lesions range from benign entities (e.g., acute necrotic collection) to potentially malignant neoplasms (e.g., IPMN) and malignant neoplasms (e.g., ductal adenocarcinoma). CT and MRI can help to differentiate pancreatic cystic lesions.

Findings

Pancreatic cystic lesions neoplasms often have pathognomonic CT and MRI characteristics. It is important to consider size, number of cysts, septa, the relationship with the main pancreatic duct, internal nodules and wall enhancement. Guidelines from different societies have been developed to promote and standardize the management and follow-up of pancreatic cystic lesions.

Conclusion

CT and MRI play a crucial role in the detection and characterization of pancreatic cystic lesions.
Transparency challenges in policy evaluation with causal machine learning: improving usability and accountability
Authors: Rehill Patrick , Biddle Nicholas
Published: October 2024

Causal machine learning tools are beginning to see use in real-world policy evaluation tasks to flexibly estimate treatment effects. One issue with these methods is that the machine learning models used are generally black boxes, that is, there is no globally interpretable way to understand how a model makes estimates. This is a clear problem for governments who want to evaluate policy as it is difficult to understand whether such models are functioning in ways that are fair, based on the correct interpretation of evidence and transparent enough to allow for accountability if things go wrong. However, there has been little discussion of transparency problems in the causal machine learning literature and how these might be overcome. This article explores why transparency issues are a problem for causal machine learning in public policy evaluation applications and considers ways these problems might be addressed through explainable AI tools and by simplifying models in line with interpretable AI principles. It then applies these ideas to a case study using a causal forest model to estimate conditional average treatment effects for returns on education study. It shows that existing tools for understanding black-box predictive models are not as well suited to causal machine learning and that simplifying the model to make it interpretable leads to an unacceptable increase in error (in this application). It concludes that new tools are needed to properly understand causal machine learning models and the algorithms that fit them.
AI, big data, and quest for truth: the role of theoretical insight
Authors: Bircan Tuba
Published: October 2024

This paper aims at exploring the dynamic interplay between advanced technological developments in AI and Big Data and the sustained relevance of theoretical frameworks in scientific inquiry. It questions whether the abundance of data in the AI era reduces the necessity for theory or, conversely, enhances its importance. Arguing for a synergistic approach, the paper emphasizes the need for integrating computational capabilities with theoretical insight to uncover deeper truths within extensive datasets. The discussion extends into computational social science, where elements from sociology, psychology, and economics converge. The application of these interdisciplinary theories in the context of AI is critically examined, highlighting the need for methodological diversity and addressing the ethical implications of AI-driven research. The paper concludes by identifying future trends and challenges in AI and computational social science, offering a call to action for the scientific community, policymakers, and society. Being positioned at the intersection of AI, data science, and social theory, this paper illuminates the complexities of our digital era and inspires a re-evaluation of the methodologies and ethics guiding our pursuit of knowledge.
Salience of infectious diseases did not increase xenophobia during the COVID-19 pandemic
Authors: Fan Lei , Tybur Joshua M. , Van Lange Paul A. M.
Published: October 2024

Multiple proposals suggest that xenophobia increases when infectious disease threats are salient. The current longitudinal study tested this hypothesis by examining whether and how anti-immigrant sentiments varied in the Netherlands across four time points during the COVID-19 pandemic (May 2020, February 2021, October 2021 and June 2022 through Flycatcher.eu). The results revealed that (1) anti-immigrant sentiments were no higher in early assessments, when COVID-19 hospitalizations and deaths were high, than in later assessments, when COVID-19 hospitalizations were low, and (2) within-person changes in explicit disease concerns and disgust sensitivity did not relate to anti-immigrant sentiments, although stable individual differences in disgust sensitivity did. These findings suggest that anecdotal accounts of increased xenophobia during the pandemic did not generalize to the population sampled from here. They also suggest that not all increases in ecological pathogen threats and disease salience increase xenophobia.
No need to look, trust me! Mutual trust and distrust in the European arrest warrant system
Authors: Bonelli Matteo , Correia de Carvalho Mateus
Published: October 2024

No cooperative scheme in EU law has displayed bigger tensions between mutual trust and fundamental rights protection than the EAW system. Despite the requirement developed by the CJEU for national courts to trust each other and recognise each other’s arrest warrants, the reality on the ground has shown high levels of distrust between national courts regarding Member States’ alignment with core EU values. In this contribution, we analyze how the CJEU has managed such tensions in the EAW system. To that effect, we first put the Court’s EAW case law into context by examining the broader language of mutual trust used by the Court in other fields of EU law. In doing so, we point out how the Court has espoused different levels of lawful distrust to be exercised in different circumstances under the scope of application of mutual trust. Given that broader context, it is contradictory for the Court to mainly view mutual trust as a requirement rather than a reality in need of permanent and continuing justification between national authorities. The latter conception of mutual trust is more apt to be the basis of EU horizontal cooperation, which must be value-based and sincere according to the Treaties. Therefore, we propose a bidimensional account of mutual trust as a legal principle, one that accommodates both trust and distrust as tools for managing the uncertainty and dynamic nature of trust-based cooperation. Finally, we explore how such account of mutual (dis)trust can be concretised by the Court and other political institutions.
A constitutional perspective on EU arms controls: mediating trade, security, and humanitarian responsibility
Authors: Vroege Bram
Published: October 2024

This article examines how European Union (EU) arms control measures are tailored to its constitutional foundations. EU Member States subject shipments of arms and components to controls so as to screen them for risks and potentially block them. In this context different Member States may make different geopolitical and humanitarian risk assessments. Existing EU measures have achieved only limited security screening harmonisation, and have left room for Member States to shirk their obligations under international humanitarian law. But in case of joint arms production, which the EU subsidises to become more autonomous, one Member State’s arms controls may block another State’s exports and thereby jeopardise cooperation. This article posits that any reform of EU arms controls should start by re-evaluating their present legal basis. A constitutional competence analysis shows that controls on arms shipments to non-EU states should be regulated in part through the Common Commercial Policy (CCP), and not just through the Common Foreign and Security Policy (CFSP). This would be consistent with other EU regulatory regimes for trade security. While a joint CFSP-CCP approach cannot fully prevent conflict, since this would require further foreign policy harmonisation, it could help foster security convergence and strengthen humanitarian due diligence mechanisms.
Elevated BCAA catabolism reverses the effect of branched-chain ketoacids on glucose transport in mTORC1-dependent manner in L6 myotubes
Authors: Mann Gagandeep , Adegoke Olasunkanmi A. John
Published: October 2024

Plasma levels of branched-chain amino acids (BCAA) and their metabolites, branched-chain ketoacids (BCKA), are increased in insulin resistance. We previously showed that ketoisocaproic acid (KIC) suppressed insulin-stimulated glucose transport in L6 myotubes, especially in myotubes depleted of branched-chain ketoacid dehydrogenase (BCKD), the enzyme that decarboxylates BCKA. This suggests that upregulating BCKD activity might improve insulin sensitivity. We hypothesised that increasing BCAA catabolism would upregulate insulin-stimulated glucose transport and attenuate insulin resistance induced by BCKA. L6 myotubes were either depleted of BCKD kinase (BDK), the enzyme that inhibits BCKD activity, or treated with BT2, a BDK inhibitor. Myotubes were then treated with KIC (200 μM), leucine (150 μM), BCKA (200 μM), or BCAA (400 μM) and then treated with or without insulin (100 nM). BDK depletion/inhibition rescued the suppression of insulin-stimulated glucose transport by KIC/BCKA. This was consistent with the attenuation of IRS-1 (Ser612) and S6K1 (Thr389) phosphorylation but there was no effect on Akt (Ser473) phosphorylation. The effect of leucine or BCAA on these measures was not as pronounced and BT2 did not influence the effect. Induction of the mTORC1/IRS-1 (Ser612) axis abolished the attenuating effect of BT2 treatment on glucose transport in cells treated with KIC. Surprisingly, rapamycin co-treatment with BT2 and KIC further reduced glucose transport. Our data suggests that the suppression of insulin-stimulated glucose transport by KIC/BCKA in muscle is mediated by mTORC1/S6K1 signalling. This was attenuated by upregulating BCAA catabolic flux. Thus, interventions targeting BCAA metabolism may provide benefits against insulin resistance and its sequelae.
Chinese word segmentation with heterogeneous graph convolutional network
Authors: Tang Xuemei , Su Qi , Wang Jun
Published: October 2024

Recently, deep learning methods have achieved remarkable success in the Chinese word segmentation (CWS) task. Some of them enhance the CWS model by utilizing contextual features and external resources (e.g., sub-words, lexicon, and syntax). However, existing approaches fail to fully use the heterogeneous features and their structural information. Therefore, in this paper, we propose a heterogeneous information learning framework for CWS, named heterogeneous graph neural segmenter (HGNSeg), which exploits heterogeneous features with the graph convolutional networks and the pretrained language model. Experimental results on six benchmark datasets (e.g., SIGHAN 2005 and SIGHAN 2008) confirm that HGNSeg can effectively improve the performance of CWS. Importantly, HGNSeg also demonstrates an excellent ability to alleviate the out-of-vocabulary (OOV) issue in cross-domain scenarios.
A Brave New World Out of the Same Old Pieces: Property Confiscation and Distribution in Postwar Czechoslovakia
Authors: Hoření Karina
Published: October 2024

This article deals with the confiscation of property from the German-speaking inhabitants of Czechoslovakia and its redistribution to the new settlers of the Czech borderlands. It shows how the social revolution—that is, the emergence of an egalitarian postwar society—was made possible by the national revolution—that is, the expulsion of the German-speaking inhabitants of Central Europe. Using the example of the industrial center of Liberec in northern Bohemia, the author shows how the Czech administration that was established after the Second World War applied the dichotomy of the Czech–German conflict to an ethnically complex postwar society and how, despite the ideology of distributing property to the “Slavs,” non-Czech minorities were discriminated against with respect to redistribution. Eventually, she analyzes how postwar Czechoslovak society was shaped, with an emphasis on the material demands of workers and collectives, even as individuals sought to achieve a middle-class lifestyle through participation in property distribution.
What are the changes in mothers’ diets after the birth of a child: results from the NutriNet-Santé cohort
Authors: Brunin Joséphine , Baudry Julia , Allès Benjamin , Ghozal Manel , Touvier Mathilde , Hercberg Serge , Lairon Denis , de Lauzon Guillain Blandine , Kesse-Guyot Emmanuelle
Published: October 2024

Childbirth is a major life-changing event, this period is an opportunity to improve eating habits. The aim of this longitudinal study was to identify and characterise dietary changes in women according to their parity status. Dietary intake data from 4194 women of childbearing age included in the NutriNet-Santé cohort were derived using a FFQ, administered in 2014 and 2018, distinguishing between organic and conventional food consumption. Women were classified into four groups: ‘previous children’, ‘multiparous’, ‘primiparous’ and ‘nulliparous’. Multi-adjusted ANCOVA models were used to estimate the changes according to the parity group. Changes in food consumption towards a more plant-based, healthier and organic diet were observed in all four groups of women, although to various degrees. In multivariable models, ‘Nulliparous’ women showed a greater improvement in terms of ‘sustainable’ food consumption than ‘previous children’ women. ‘Primiparous’ women significantly increased their energy intake (+349 (269–429) kcal/d) and their consumption of dairy products (+30 (3–56) g/d), and they significantly decreased their consumption of alcohol (–23 (–32–15) g/d), coffee and tea (–107 (–155–60) g/d). Regarding organic food, ‘nulliparous’ women increased their consumption more than ‘previous children’ and ‘primiparous’ women were those who were most frequently in the top quintile of organic food increase. Although there were dietary changes in all groups of women according to their parity, childless women have a shift moving towards a more sustainable diet. Women who had a first child reduced their alcohol and caffeine consumption.
Serum concentrations of lipids, ketones and acylcarnitines during the postprandial and fasting state: the Postprandial Metabolism (PoMet) study in healthy young adults
Authors: Anfinsen Åslaug Matre , Myklebust Vilde Haugen , Johannesen Christina Osland , Christensen Jacob Juel , Laupsa-Borge Johnny , Dierkes Jutta , Nygård Ottar , McCann Adrian , Rosendahl-Riise Hanne , Lysne Vegard
Published: October 2024

To improve the interpretation and utilisation of blood lipids, ketones and acylcarnitine concentrations as biomarkers in clinical assessments, more information is needed on their dynamic alterations in response to dietary intake and fasting. The aim of this intervention study was to characterise the changes in serum lipid, ketone and acylcarnitine concentrations 24 h after a standardised breakfast meal. Thirty-four healthy subjects (eighteen males and sixteen females) aged 20–30 years were served a breakfast meal (∼500 kcal, 36 E% fat, 46 E% carbohydrates, 16 E% protein, 2E% fibre), after which they consumed only water for 24 h. Blood samples were drawn before and at thirteen standardised timepoints after the meal. Metabolite concentrations were plotted as a function of time since the completion of the breakfast meal. Results demonstrated that concentrations of HDL-cholesterol and LDL-cholesterol decreased until ∼2 h (–4 % for both), while TAG concentrations peaked at 3 h (+27 %). Acetoacetate and β-hydroxybutyrate were highest 24 h after the meal (+433 and +633 %, respectively). Acetylcarnitine, butyrylcarnitine, hexanoylcarnitine, octanoylcarnitine, decanoylcarnitine and dodecanoylcarnitine reached the lowest values at 60 min (decreases ranging from –47 to –70 %), before increasing and peaking at 24 h after the meal (increases ranging from +86 to +120 %). Our findings suggest that distinguishing between fasting and non-fasting blood samples falls short of capturing the dynamics in lipid, ketone, carnitine and acylcarnitine concentrations. To enhance the utility of serum acylcarnitine analyses, we strongly recommend accounting for the specific time since the last meal at the time of blood sampling.
‘He laid His hand upon both’: Self-punishment, vicarious punishment and Gregory's spirituality of the cross in the Moralia in Job
Authors: Underhill Tom
Published: October 2024

Gregory the Great's Moralia in Job has been said to mark a transitional phase in the development of atonement doctrine. I argue that the Moralia cohesively portrays Christ's redemptive work as achieving something in two directions: towards God, a vicarious payment of humanity's debt of punishment; towards humanity, an efficaciously convicting and restorative example. This sustains a spirituality in which exacting and self-denying moral effort rests on freedom from judgement and on the death accomplished by the Mediator. Engaging the Moralia in this manner illuminates patristic exegetical sensibilities and proves instructive about how the fathers fit into later taxonomies of atonement models.
Intestinal Parasitic Infection in Roman Britain: Integrating New Evidence from Roman London
Authors: Ledger Marissa L. , Redfern Rebecca , Mitchell Piers D.
Published: October 2024

The aim of this study is to estimate the minimum prevalence of intestinal parasites in the population of Roman London through analysis of pelvic sediment from 29 third- to fourth-century burials from the 1989 excavations of the western cemetery at 24–30 West Smithfield, 18–20 Cock Lane and 1–4 Giltspur Street (WES89). Microscopy was used to identify roundworm eggs in 10.3 per cent of burials. We integrate these results with past palaeoparasitological work in the province of Britannia to explore disease, hygiene and diet. The most commonly found parasites (whipworm and roundworm) were spread by poor sanitation, but other species caught from animals were also present (fish tapeworm, beef/pork tapeworm and liver flukes). Parasite diversity was highest in urban sites. The health impacts of these infections range from asymptomatic to severe.
Religion and responsibility in international relations: Thatcher, Mahathir, and The Satanic Verses
Authors: Smith David T.
Published: October 2024

The crisis over Salman Rushdie’s novel The Satanic Verses exposed the contrasting ways Western and Muslim actors understand the place of religion in international order and the responsibilities of states in religious controversies. No other Muslim national leader supported Ayatollah Khomeini’s call for Rushdie’s death in 1989, but many Muslims expressed anger and disbelief that Britain and Western powers could not restrict a book that caused so much international disturbance. This paper seeks to understand this discord through the overlapping but conflicted language games of Western and Muslim national leaders. It analyses a previously unreported exchange of letters between British prime minister Margaret Thatcher and Malaysian prime minister Mahathir Mohamad, along with other recently released archival material from the diplomatic crisis. These letters reflected different unwritten rules informing the actors’ understandings and practices of international order, despite their shared acceptance of the sovereignty of national states. For Mahathir, the Western world was itself a religious identity, and its collective propagation of The Satanic Verses compounded a religious insult to the Muslim world. But Thatcher and other British actors did not see religious identities, especially their own, as basic elements of international relations, instead reasserting the secular primacy of national states.
Testing the relationship between preferences for infant-directed speech and vocabulary development: A multi-lab study
Authors: Soderstrom Melanie , Rocha-Hidalgo Joscelin , Muñoz Luis E. , Bochynska Agata , Werker Janet F. , Skarabela Barbora , Seidl Amanda , Ryjova Yana , Rennels Jennifer L. , Potter Christine E. , Paulus Markus , Ota Mitsuhiko , Olesen Nonah M. , Nave Karli M. , Mayor Julien , Martin Alia , Machon Lauren C. , Lew-Williams Casey , Ko Eon-Suk , Kim Hyunji , Kartushina Natalia , Kammermeier Marina , Jessop Andrew , Hay Jessica F. , Havron Naomi , Hannon Erin E. , Kiley Hamlin J. , Gonzalez-Gomez Nayeli , Gampe Anja , Fritzsche Tom , Frank Michael C. , Durrant Samantha , Davies Catherine , Cashon Cara , Byers-Heinlein Krista , Boyce Veronica , Black Alexis K. , Bergmann Christina , Anderson Laura , Alshakhori Mohammed K. , Al-Hoorie Ali H. , Tsui Angeline S. M.
Published: October 2024

From early on, infants show a preference for infant-directed speech (IDS) over adult-directed speech (ADS), and exposure to IDS has been correlated with language outcome measures such as vocabulary. The present multi-laboratory study explores this issue by investigating whether there is a link between early preference for IDS and later vocabulary size. Infants’ preference for IDS was tested as part of the ManyBabies 1 project, and follow-up CDI data were collected from a subsample of this dataset at 18 and 24 months. A total of 341 (18 months) and 327 (24 months) infants were tested across 21 laboratories. In neither preregistered analyses with North American and UK English, nor exploratory analyses with a larger sample did we find evidence for a relation between IDS preference and later vocabulary. We discuss implications of this finding in light of recent work suggesting that IDS preference measured in the laboratory has low test-retest reliability.
A Millian Case against Epistemic Arguments for Federalism
Authors: Da Silva Michael
Published: October 2024

John Stuart Mill is central to parallel debates in mainstream contemporary political epistemology and philosophy of federalism concerning the epistemic dimension(s) of legitimate authority. Many scholars invoke Mill to support epistemic arguments for democratic decision-making and decentralized federalism as a means of conferring democratic legitimacy. This article argues that Millian considerations instead provide reason to reject common epistemic arguments for decentralized federalism. Combining Mill's own insights about the epistemic costs of decentralization and recent work in philosophy, politics, and economics undermines purportedly Millian arguments for federalism focused on political experimentation, diversity and participation. Contrary to many interpretations, Millian considerations weaken, rather than strengthen, arguments for federalism. Any valid justification for federalism must instead rest on non-epistemic considerations. This conclusion is notable regardless of how one interprets Mill. But it also supports Mill's stated preference for local decisions subject to central oversight.
Morphological and Structural Characterization of Shortening Landforms on Mars
Authors: McCullough Leta R. , Crane Kelsey T. , Loveless Stephan R. , Klimczak Christian
Published: October 2024

The lithosphere of Mars accommodates horizontal shortening through folding and faulting, producing landforms described as wrinkle ridges or lobate scarps. Despite this nomenclature, we lack a deep understanding of the drivers of morphological differences observed between landform types. This study aims to develop a quantitative model for shortening landform classification based on surface morphology, subsurface architecture, and strain accommodation, facilitating interpretations of where and how lithospheric stresses are recorded. We developed this model by mapping 100 shortening landforms in a Geographic Information System, recording 12 unique geomorphic parameters such as length and asymmetry, and estimating the strain of each landform. We conducted a Discriminant Function Analysis (DFA) using surface morphometrics. This DFA produced a predictive linear function for categorizing wrinkle ridges and lobate scarps and for quantifying which landforms were exemplars within those categories. The three most influential variables on the surface morphometry DFA were the maximum width, forelimb slope, and back limb length. We then modeled the subsurface structural geology of 50 landforms using MOVE Structural Geology Modeling Software and conducted a second DFA based on subsurface metrics. DFA was most influenced by the dip and depth of the lower ramp base. When both surface morphology and subsurface geometry are input into single DFA, wrinkle ridges and lobate scarps can be distinguished quantitatively 96% of the time. Our results also show that lobate scarps accommodate more strain and imply that studies should consider landform type when interpreting local, regional, and global geological stress histories.
Machine‐Assisted Physical Closure for Coarse Suspended Sediments in Vegetated Turbulent Channel Flows
Authors: Li Shuolin , Qu Yongquan , Zheng Tian , Gentine Pierre
Published: October 2024

The parameterization of suspended sediments in vegetated flows presents a significant challenge, yet it is crucial across various environmental and geophysical disciplines. This study focuses on modeling suspended sediment concentrations (SSC) in vegetated flows with a canopy density of avH ∈ [0.3, 1.0] by examining turbulent dispersive flux. While conventional studies disregard dispersive momentum flux for avH > 0.1, our findings reveal significant dispersive sediment flux for large particles with a diameter‐to‐Kolmogorov length ratio when dp/η > 0.1. Traditional Rouse alike approaches therefore must be revised to account for this effect. We introduce a hybrid methodology that combines physical modeling with machine learning to parameterize dispersive flux, guided by constraints from diffusive and settling fluxes, characterized using recent covariance and turbulent settling methods, respectively. The model predictions align well with reported SSC data, demonstrating the versatility of the model in parameterizing sediment‐vegetation interactions in turbulent flows.
Cold and hot tumors: from molecular mechanisms to targeted therapy
Authors: Wu Bo , Zhang Bo , Li Bowen , Wu Haoqi , Jiang Meixi
Published: October 2024

Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which has shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment in cancer therapy, only a minority of patients exhibit a positive response to it. In patients with solid tumors, those who respond well to ICB treatment typically demonstrate an active immune profile referred to as the “hot” (immune-inflamed) phenotype. On the other hand, non-responsive patients may exhibit a distinct “cold” (immune-desert) phenotype, differing from the features of “hot” tumors. Additionally, there is a more nuanced “excluded” immune phenotype, positioned between the “cold” and “hot” categories, known as the immune “excluded” type. Effective differentiation between “cold” and “hot” tumors, and understanding tumor intrinsic factors, immune characteristics, TME, and external factors are critical for predicting tumor response and treatment results. It is widely accepted that ICB therapy exerts a more profound effect on “hot” tumors, with limited efficacy against “cold” or “altered” tumors, necessitating combinations with other therapeutic modalities to enhance immune cell infiltration into tumor tissue and convert “cold” or “altered” tumors into “hot” ones. Therefore, aligning with the traits of “cold” and “hot” tumors, this review systematically delineates the respective immune characteristics, influencing factors, and extensively discusses varied treatment approaches and drug targets based on “cold” and “hot” tumors to assess clinical efficacy.
Sequential responsive nano-PROTACs for precise intracellular delivery and enhanced degradation efficacy in colorectal cancer therapy
Authors: Yang Liuqing , Yang Ye , Zhang Jing , Li Minghui , Yang Long , Wang Xing , Chen Meifang , Zhang Hua , He Bing , Wang Xueqing , Dai Wenbing , Wang Yiguang , Zhang Qiang
Published: October 2024

PROteolysis TArgeting Chimeras (PROTACs) have been considered the next blockbuster therapies. However, due to their inherent limitations, the efficacy of PROTACs is frequently impaired by limited tissue penetration and particularly insufficient cellular internalization into their action sites. Herein, based on the ultra-pH-sensitive and enzyme-sensitive nanotechnology, a type of polymer PROTAC conjugated and pH/cathepsin B sequential responsive nanoparticles (PSRNs) are deliberately designed, following the construction of the PROTAC for Cyclin-dependent kinase 4 and 6 (CDK4/6). Colorectal cancer (CRC) which hardly responds to many treatments even immune checkpoint blockades was selected as the tumor model in this study. As a result, PSRNs were found to maintain nanostructure (40 nm) in circulation and efficiently accumulated in tumors via enhanced permeation and retention effect. Then, they were dissociated into unimers (<10 nm) in response to an acidic tumor microenvironment, facilitating tumor penetration and cellular internalization. Eventually, the CDK4/6 degrading PROTACs were released intracellularly following the cleavage of cathepsin B. Importantly, PSRNs led to the enhanced degradation of target protein in vitro and in vivo. The degradation of CDK4/6 also augmented the efficacy of immune checkpoint blockades, through the upregulation of programmed cell death-ligand 1 (PD-L1) expression in cancer cells and the suppression of regulatory T cells cell proliferation in tumor microenvironment. By combination with α-PD-1, an enhanced anti-tumor outcome is well achieved in CT26 tumor model. Overall, our study verifies the significance of precise intracellular delivery of PROTACs and introduces a promising therapeutic strategy for the targeted combination treatment of CRC.
Latexin deficiency limits foam cell formation and ameliorates atherosclerosis by promoting macrophage phenotype differentiation
Authors: He Guozhang , Ni Yuanting , Hua Rong , Wan Huaibin , Tan Yanhui , Chen Qiwei , Xu Shaohua , Yang Yuzhong , Zhang Lijun , Shu Wei , Huang Ke-Bin , Mo Yi , Liang Hong , Chen Ming
Published: October 2024

Latexin (LXN) is abundant in macrophages and plays critical roles in inflammation. Much is known about macrophages in atherosclerosis, the role of macrophage LXN in atherosclerosis has remained elusive. Here, the expression of LXN in human and mouse atherosclerotic lesions was examined by immunofluorescence and immunohistochemistry. LXN knockout and LXN/ApoE double-knockout mice were generated to evaluate the functions of LXN in atherosclerosis. Bone marrow transplantation (BMT) experimentation was carried out to determine whether macrophage LXN regulates atherosclerosis. We found that LXN is enriched in human and murine atherosclerotic lesions, mainly localized to macrophages. LXN deletion ameliorated atherosclerosis in ApoE-/- mice. BMT demonstrate that deletion of LXN in bone marrow protects ApoE-/- mice against atherosclerosis. Mechanistically, we found that LXN targets and inhibits JAK1 in macrophages. LXN deficiency stimulates the JAK1/STAT3/ABC transporter pathway, thereby enhancing the anti-inflammatory and anti-oxidant phenotype, cholesterol efflux, subsequently minimizing foam cell formation and atherosclerosis. Gene therapy by treatment of atherosclerotic mice with adeno-associated virus harbouring LXN-depleting shRNA attenuated the disease phenotype. In summary, our study provides new clues for the role of LXN in the pathological regulation of atherosclerosis, and determines that LXN is a target for preventing atherosclerosis, which may be a potential new anti-atherosclerosis therapeutic target.