bluuebunny/crossref_metadata_2025 huggingface dataset:
THE RESILIENCE OF MINORITY AND FEMALE ENTREPRENEURS: A LOOK AT ETHNICITY AND GENDER
Authors: SHELTON LOIS M , LUGO MARIA V
Published: December 2021

By exploring the resilience skills of African-American, Hispanic and female entrepreneurs, this study examines entrepreneurs who face great obstacles, but still start more businesses than their White counterparts (Fairlie and Robb, 2009). The experiences of minorities and women lead to the development of risk and protective factors that result in differences in resilience. Here we present a model of resilience informed by the psychology and educational literatures which illustrates how particular experiences of minorities and women enable them to develop higher levels of resilience. In this model, the adaptive cultures of women and minorities equip them to overcome the adversity which arises from their social stratification as marginalized groups. We then test this model using a nationally representative, stratified random sample of 340 Black, Hispanic and White male and female entrepreneurs. The empirical results from two-way ANOVAs, Kruskal-Wallis H tests and multiple regression analysis indicate that Blacks and Hispanics had higher social resilience than White entrepreneurs, and that women had greater self and social resilience than male entrepreneurs.
On a New Family of Extremal Positive Maps of Three-Dimensional Matrix Algebra
Authors: Ługiewicz Piotr , Olkiewicz Robert
Published: December 2021

We present a new one-parameter family of extremal positive maps on the three-dimensional matrix algebra. The new elements are characterized as mappings that preserve a one-dimensional orthogonal projector.
A Novel Self-Healing Conversion Film Formed on Rebar in Solution Containing Cerium and Molybdenum Ions
Authors: An Hongze , Ngendabanyikwa Donatien , Meng Guozhe , Wang Yanqiu , Wang Junyi , Liu Bin , Wang Fuhui
Published: December 2021

A novel conversion film containing cerium and molybdenum was synthesized on the rebar surface, and then the pitting sensitivity of the rebar was improved in a concrete environment containing chloride. This conversion film presented a two-layer structure, which involved CeMoOx as the outer layer and FeOx as the inner layer. The film with two-layer structure exhibited a strong corrosion resistance after being immersed in an alkaline environment (pH = 12.5) added with 0.1 M NaCl, and the charge transfer resistance (R
t) could reach 5.88 × 106 Ω·cm2 after immersion for 1600 h, which was approximately 2.5 times the initial R
t value. Moreover, it was found that the film has a self-heal property when being damaged beyond the pitting potential. The anticorrosion mechanism of the film and its self-healing mechanism were discussed in depth in this study.
New Insight into Li+ Dynamics in Lithium Bimetal Phosphate
Authors: Savignac Laurence , Griffin John M. , Schougaard Steen B.
Published: December 2021

Substitution of iron by other transition metals within the remarkably stable olivine framework is of interest considering the expected gain in energy density. However, manganese rich olivine materials suffer from sluggish redox kinetics, leading to electrochemical performances at high current densities which are below expectations. The source of the kinetic limitations is not clear, with multiple processes having been proposed, including low bulk electronic conductivity, structural instability of Mn3+ and a phase transition mechanism. This study employed 7Li MAS NMR relaxation techniques to indirectly probe Li+ dynamics using various stoichiometry of chemically prepared Li
x
MnyFe1-yPO4 (0 ≤ (x, y) ≤ 1). Focusing on the particle level, the aim was to understand how the different crystal phases, alongside the Mn structural contribution, influence Li+ transport at each stage of the oxidation process. Significantly, the formation of an olivine solid solution with vacancies within this progression gave rise to a faster 7Li transverse relaxation derived from superior Li+ motion.
Communication—Lithium Titanate as Mg-Ion Insertion Anode for Mg-Ion Sulfur Batteries Based on Sulfurated Poly(acrylonitrile) Composite
Authors: Trück Janina , Wang Peiwen , Buch Elizaveta , Groos Jonas , Niesen Stefan , Buchmeiser Michael R.
Published: December 2021

Spinel lithium-titanate Li4Ti5O12 (LTO) is a promising anode material for magnesium batteries due to its non-toxicity, low-cost, zero-strain characteristics and long-term stability. Nevertheless, the application of LTO in a magnesium full cell has been rarely investigated. Herein, we give a proof of concept for the feasibility of LTO as anode in full magnesium ion batteries, which might prevent the passivation of metallic Mg anodes. Mg2+ was electrochemically inserted into LTO prior to cycling against a sulfur-based cathode material, i.e. sulfurated poly(acrylonitrile), SPAN, resulting in stable cycle performance with 800 mAh gS
−1 at 0.3C and high-rate capability.
From the President: Change
Authors: Hall Dale E.
Published: December 2021

Benjamin Franklin said that only two things in this world are certain: death and taxes. While both seem pretty certain to me, I’d add a third: change. You may not know what the future is going to be like, but you can bet that it will be different from the past and the present in important and often unpredictable ways.
Necrotizing Enterocolitis in a 34-Week Premature Infant with COVID-19
Authors: Mannix Mary K. , Blood Danielle , Gomez-Duarte Oscar G. , Davidson Lauren
Published: December 2021

Coronavirus disease 2019 (COVID-19) is a viral respiratory infection caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While SARS-CoV-2 is a leading cause of morbidity and mortality in older adults, COVID-19 also affects newborn infants in nurseries and the Neonatal Intensive Care Units (NICUs). The majority of infected neonates are believed to acquire SARS-CoV-2 by horizontal transmission, and most of them have asymptomatic or mild symptomatic infections. In rare cases, infants with COVID-19 may have severe complications resulting in death. We report a case of COVID-19 in a premature neonate born at 34 weeks gestational age who presented with hypothermia and respiratory distress and subsequently developed clinical and radiological signs of necrotizing enterocolitis (NEC). The neonate received medical management, including antibiotics, suspension of gastric feeds, and intensive NICU support. The neonate’s clinical condition improved without surgical intervention, and after 10 days of antibiotics and gradual reestablishment of gastric feeds, patient health condition returned to normal, and weeks later, he was discharged home. COVID-19 in infants is frequently asymptomatic or associated with mild disease, and in rare cases, it may be associated with severe gastrointestinal complications including NEC.
Factors Associated with Skin Cancers in People with Albinism in Togo
Authors: Mouhari-Toure Abas , Akakpo Sefako Abla , Teclessou Julienne Noude , Gnossike Piham , Adam Saliou , Mahamadou Garba , Kassang Panawé , Elegbede Yvette , Darre Tchin , Kombate Koussake , Pitché Palokinam , Saka Bayaki
Published: December 2021

Objective. The aim of this study was to identify the factors associated with skin cancers in people with albinism (PWA) in Togo. Method. This is a retrospective analytical study of the records of PWA examined during five dermatological consultation campaigns from 2019 to 2021. Results. During the study period, 517 PWA were seen. Sixty-four (12.3%) of these PWA had presented with 137 cases of skin cancer. The sex ratio (M/F) was 0.9. The average age of PWA with skin cancer was 39.69 ± 15.61 years and that of PWA without skin cancer was 19.17 ± 15.24 years (

p
≤
0.001

). The 137 cases of skin cancers were dominated by basal cell carcinomas (45.9%). These skin cancers were located preferentially in the cephalic region (77 cases; 56.2%), followed by the upper limbs (33 cases; 24.1%). In multivariate analysis, the risk factors for skin cancers in PWA were age over 39 years (

p
≤
0.001

) and the presence of actinic keratoses (

p
≤
0.001

). In contrast, the presence of ephelides (

p
=
0.018

) was a protective factor. Conclusion. This study confirms that advanced age and actinic keratoses are risk factors for skin cancer in PWA, in connection with the cumulative role of solar radiation. Its originality lies in the identification of ephelides as a protective factor. The knowledge and consideration of these risk factors will make it possible to optimise strategies for the prevention of skin cancers in PWA.
Management of Buccal Screw Access Hole Positioning for Implant Fixed Complete Dentures: A Report of Two Patients and a Proposed Decision Tree
Authors: Alzoubi Fawaz
Published: December 2021

The present report demonstrated the use of two methods to correct the positioning of buccal screw access holes in both implant- and abutment-level implant-supported fixed complete dentures in two patients. The report suggests that nonaxially tightened abutments (in this report, dynamic abutments), angled multi-unit abutments, and the use of a milled framework with individual crowns aid in masking buccal screw access holes while maintaining the benefits of a screw-retained design. A decision tree is also proposed to facilitate the workflow when faced with such clinical scenarios.
Application of Dynamic Enhanced Magnetic Resonance Imaging in the Diagnosis of Hematological Malignancies
Authors: Shao Yanping , Bao Xueping , Song Caifang , Cui Danping
Published: December 2021

The use of dynamic enhanced magnetic resonance imaging technology can effectively explore the diagnosis and clinical application of hematological malignancies. This paper selected 60 patients with hematological malignancies from 2015 to 2019; all of whom were diagnosed with hematological malignancies, including 40 men and 20 women, aged between 40 and 77 years. The main clinical manifestations of the patient are hematological malignancies, fever, and other symptoms. We used Siemens 3.0T to perform MRI and dynamic enhanced MRI examinations on 30 patients with hematological tumors. The PACS system was used to collect and organize clinical data. All patients were pathologically confirmed and clinically diagnosed with hematological malignancies. Based on the clinical data of the patients, retrospective analysis and summary were conducted and the clinical manifestations of hematological malignancies were discussed. The results showed that the diagnostic accuracy of 30 cases of dynamic enhanced MRI was 100%, while the diagnostic accuracy of ordinary MRI was lower than that of dynamic enhanced MRI,

P
<
0.05

, and the difference was statistically significant. In addition, compared with dynamic enhanced MRI and MRI,

P
>
0.05

, the difference was not statistically significant. Therefore, the application of dynamic enhanced MRI in the diagnosis of hematological malignancies is valuable.
Solving No-Wait Flow Shop Scheduling Problem Based on Discrete Wolf Pack Algorithm
Authors: Lai Rongshen , Gao Bo , Lin Wenguang
Published: December 2021

Aiming at the no-wait flow shop scheduling problem with the goal of minimizing the maximum makespan, a discrete wolf pack algorithm has been proposed. First, the methods for solving the no-wait flow shop scheduling problem and the application research of the wolf pack algorithm were summarized, and it was pointed out that there was lack of research on the application of the wolf pack algorithm to solve the no-wait flow shop scheduling problem. According to the analysis of characteristics of the no-wait flow shop scheduling problem, the individual wolf was coded by a decimal integer; wolf searching behavior was realized through the exchange of different code bits in the individual wolf, and the continuous code segment of the head wolf was randomly selected to replace the corresponding code of the fierce wolf, by which the behaviors of wolves raiding and sieging were realized, and the population was updated according to the rule of “survival of the strong.” In particular, to fully explore the potential optimal solution in the solution space, loop operations were added to the wandering, summoning, and siege processes. Finally, based on a comparison with the leapfrog algorithm and the genetic algorithm, the effectiveness of the algorithm was verified.
Experience with Tetanus in a Tertiary Care Hospital in Sudan: A Retrospective Review
Authors: Dafallah Mumen Abdalazim , Ragab Esraa Ahmed , Mohamed Ahmed Elawad Omer Ali
Published: December 2021

Introduction. Tetanus is still a major health issue, especially in rural areas, and is associated with high morbidity and mortality rate. This study was conducted to describe the pattern of presentation and treatment outcome among adult patients infected with tetanus in our environment. Materials and Methods. This is a descriptive retrospective hospital-based study conducted in Wad Medani teaching hospital, central Sudan. A total of thirty-one patients were enrolled in this study in the period between January 2018 and December 2020. Results. Thirty-one patients were infected with tetanus during the study period. They were 23 (74.2%) males and 8 (25.8%) females with a male-to-female ratio of 2.875 : 1. Their ages ranged from 20 to 70 years, and most of them (48.4%) were free workers. Acute injuries were the most common portal of entry (64.51%), and commonly involved the lower limbs (48.38%). Lock jaw (54.8%), muscle spasm (51.6%), and neck pain and stiffness (45.2%) were the most common presentation. Supportive measures along with surgical toilet and debridement, human tetanus immunoglobulin, antibiotics, and muscle relaxants were initiated in all patients. The most common antibiotics used were Penicillin V and Ceftriaxone. A muscle relaxant was administered to aid in relieving the spasms. Complication rate was 61.29% and included pulmonary and cardiovascular complications. Fifteen patients died accounting for an overall mortality rate of 48.4%. Conclusions. Tetanus remains a disease with high morbidity and mortality. The unknown/incomplete vaccination status among study participants, inadequate management, and lack of equipped resources lead to a devastating outcome as in Sudan.
Soft Tissue Dehiscence Associated with a Titanium Patient-Specific Implant: A Prosthetic Solution as an Alternative to Soft Tissue Grafting
Authors: Abbas Sharaf Eldeen M. , ELKhashab Mohamed A.
Published: December 2021

Patients. This clinical report describes the detailed prosthodontic management of a 23-year-old male patient suffering from soft tissue complication following the placement of a 3d-printed titanium patient-specific implant. This implant was implemented simultaneously with the resection of a calcifying cystic odontogenic tumor related to the maxillary arch. Later, soft tissue dehiscence and implant exposure were encountered with subsequent food impaction, infection, and pus discharge. The treatment plan was to fabricate removable partial denture. The prosthesis was planned to be retained by bar and clip attachment on the patient-specific implant side, while on the other side, the removable prosthesis was allowed to engage two abutments with an embrasure clasp assembly in addition to covering the palatal tissues to offer protection for the soft tissue dehiscence against food impaction. Discussion. Soft tissue dehiscence and implant exposure are among the frequently reported complications associated with the patient-specific implant. The resulting infection complicates the prognosis of the implemented implant and necessitates, in some occasions, its removal. The selection of the removable prosthesis to cover soft tissue dehiscence was a conservative alternative to the implant removal as it protects the exposed titanium surface from food impaction while maintaining the implant functionality. Conclusion. Three-year follow-up showed complete resolution of the patient’s complaints while fulfilling the patient’s aesthetic and functional demands and indicates that the use of detachable overlay prosthesis could be one of the proposed treatment options.
A Rare Case of Systemic Sarcoidosis in a Middle-Aged Female with a Solitary Thyroid Nodule
Authors: Bangolo Ayrton , Bukasa Kakamba John , Atoot Ali , Jurri Mohammad , Mahmoud Ashraf , Lo Arthur Oliver , Song Kunchang , Sirajuddin Syed , Atoot Adam
Published: December 2021

Sarcoidosis is a multisystem inflammatory disease characterized by the presence of noncaseating granulomas. Sarcoidosis can affect any organ of the body, the lung being the most affected. Sarcoidosis rarely affects the thyroid gland, and only a few cases of thyroid-related sarcoidosis have been reported in the literature. Herein, we report a case of systemic sarcoidosis with multiple organ involvement in a patient with a solitary left thyroid nodule and benign Fine Needle Aspiration (FNA) findings. The patient was eventually diagnosed with thyroid sarcoidosis using a core needle biopsy of the thyroid nodule. With this case report, we highlight the limitations of the FNA. This case report has the objective to encourage clinicians to include thyroid sarcoidosis in the differential diagnosis of thyroid nodules in patients with systemic sarcoidosis even with unremarkable FNA findings.
Knowledge, Attitude, and Practice towards Malaria among People Attending Mekaneeyesus Primary Hospital, South Gondar, Northwestern Ethiopia: A Cross-Sectional Study
Authors: Flatie Belaynesh Tazebew , Munshea Abaineh
Published: December 2021

Background. Malaria is one of the most severe public health problems worldwide. It is a leading cause of suffering, death, and socioeconomic problem, especially in many developing countries like Ethiopia. To introduce appropriate preventive and control measures, assessment of community’s levels of knowledge, attitude, and preventative practices regarding malaria is crucial. This study was aimed at assessing the knowledge, attitude, and practice (KAP) towards malaria and its preventive and control methods among people attending Mekaneeyesus primary hospital, South Gondar, northwestern Ethiopia. Methods. A hospital-based cross-sectional study was conducted from September 2017 to April 2018. A structured questionnaire was administered to collect data on sociodemographic characteristics and KAP of 390 randomly selected individuals. The data collecting tool was pretested before commencing the actual data collection. The data were analyzed using the SPSS version 21 software.

P

values less than 0.05 were considered statistically significant. Results. The overall prevalence rate of malaria in the study area was 8.5%. Nearly two-third of the participants had good knowledge (63.1%) and positive attitude (62.6%) scores towards malaria while only half of the participants had (50.8%) good practice score towards malaria prevention and control measures. Sex, age category, family monthly income, residence, and occupational and educational status of the participants were significantly associated with knowledge and practice scores (

P
<
0.05

). The odds of malaria were 26.93 (

CI
=
3.67
‐
197.47

,

P
=
0.001

) and 13.09 (

CI
=
0.93
‐
183.47

,

P
=
0.036

) times higher among individuals who had poor knowledge and poor practice towards malaria, respectively, as compared to individuals who were knowledgeable and had good practice score towards malaria. Conclusion. The overall knowledge score, attitude, and practice level of respondents towards malaria was relatively good. However, significant proportion of the participants still have misconception about the cause, sign and symptoms, modes of transmission, and practices towards prevention methods of malaria. Thus, health education which is aimed at raising community’s awareness about the disease is necessary to address the gaps identified by this study.
Big Data Information under Proportional Hazard Mathematical Model in Analysis of Hepatitis B Virus Infection Data of Patients with Interventional Liver Cancer through Antiviral Therapy of Entecavir
Authors: Zhang Yichi , Zhao Shuai , Ding Han , Song Xiaoling , Miao Huijie , Cui Xuya , Wang Jian , Han Bing
Published: December 2021

The objective of this study was to analyze the application of proportional hazard mathematical model (PHMM) in Hepatitis B Virus (HBV) infection analysis of interventional liver cancer patients treated with entecavir, so as to provide data support for clinical diagnosis and treatment. Based on the survival analysis, the treatment factor x was undertaken as an independent variable to perform linear regression. The regression model took the hazard rate function as the dependent variable to establish an exponential regression equation to construct a PHMM. 136 patients with primary liver cancer receiving interventional chemoembolization combined with the drug (entecavir) were selected as the experimental group, who were in the computer gene expression omnibus (GEO). 87 patients with primary liver cancer who underwent interventional chemoembolization therapy without antiviral treatment were taken as the control group. The PHMM was adopted for comprehensive analysis. In addition, the factors affecting the virological response to antiviral therapy were analyzed using the multiple logistic regression. The results revealed that HBV deoxyribonucleic acid (DNA) negative conversion rate, Hepatitis B e-Antigen (HBeAg) negative conversion rate, and HBeAg serological conversion rate in the experimental group were much higher than those in the control group (

P
<
0.05

). HBV DNA level and proportion of HBsAg <100 IU/mL in the experimental group were much lower than those in the control group (

P
<
0.05

). The virological breakthrough rate and incidence of adverse events at week 24 in the experimental group were greatly lower than those in the control group (

P
<
0.05

). The adverse virological response of patient was positively correlated with HBV DNA load and HBeAg status and negatively correlated with alanine aminotransferase (ALT) level (

P
<
0.05

). Therefore, entecavir can significantly inhibit HBV DNA replication in patients with liver cancer, showing high antiviral effect. High baseline HBV DNA load, positive HBeAg, and low baseline alanine aminotransferase levels were independent risk factors for adverse virology response to entecavir antiviral therapy, which provided a reference for the selection of antiviral drugs for HBV infection.
Simulation-Based Evaluation of Variation in Left-Turn Paths in the Coordinated Intersection Management
Authors: Yang Menglin , Yu Hao , Bai Lu
Published: December 2021

Coordinated intersection management (CIM) has gained more attention with the advance of connected and autonomous vehicle technology. The optimization of passing schedules and conflict separation between conflicting vehicles are usually conducted based on the predefined travelling paths through the intersection area in the CIM. In real-world implementation, however, the diversity of turn paths exists due to multiple factors such as various vehicle sizes and automation control algorithms. The aim of this paper is to investigate how the variation in left-turn paths affects the feasibility and viability of optimal passing schedules, as well as the safety and efficiency of intersection operation. To do this, we start with identifying six typical left-turn paths to represent the variation. A scenario-based simulation is first conducted by using each of the paths as the nominal path. The optimal schedules and the corresponding alternative schedules are generated to calculate indicators for nominal performance, average performance, and robustness. The best path is selected in terms of schedule optimality and robustness. With schedules obtained by solving CIM models using the selected path, the left-turning CAVs are assumed to travel along one of the six paths randomly to simulate the path divergence. A surrogate safety measure, PET, is utilized to assess the safety of the intersection under CIM. The theoretical PET with the nominal path and the actual PET with the random path are calculated for each conflict event. Comparisons of two PET sets show the increase in conflict risk and vehicle delay. The conclusion can be drawn that the variation in left-turn paths causes the decline in safety level and travelling efficiency and should be considered in the CIM model to ensure safe and efficient implementation in the intersection.
A Novel Estimation Method of Wind Speed and Direction Based on GNSS/INS/ADS Integrated Navigation
Authors: Zhang Jingjuan , Cong Hao , Wang Xueyun
Published: December 2021

Arriving on time is of great importance for flight management and passenger experience. One of the essential factors that impacts on‐time arrival is the wind condition. Accurate information of wind speed and direction around the fuselage helps to improve the performance of on‐time arrival and four‐dimensional trajectory (4DT) planning. To determine accurate wind information in real‐time, a novel airborne estimation method of wind speed and direction is proposed in this paper. Inertial Navigation System (INS), Global Satellite Navigation System (GNSS), and Air Data System (ADS) are fused in an Unscented Kalman Filter (UKF), which provides great accuracy and robustness in nonlinearity conditions. The dynamic models of wind are established, and implementations of the UKF are detailed. Finally, simulations are designed and the effectiveness of the proposed method is verified through the comparison with the traditional direct measurement method. Results demonstrate that the accuracy of wind speed and direction obtained by our method is nearly two times higher than the traditional direct measurement method.
Multicamera Calibration Optimization Method Based on Improved Seagull Algorithm
Authors: Du Shuai , Wang Jianyu , Guo Jia
Published: December 2021

There are some problems in the process of camera calibration, such as insufficient accuracy and poor accuracy. Based on the seagull algorithm, the adaptive differential evolution algorithm is combined with the seagull algorithm to optimize the multicamera calibration. The seagull algorithm can achieve good results on multiparameter problems and effectively avoid falling into local optima. In this paper, the adaptive differential search algorithm is adopted to improve the local search ability and optimize the local search and global search ability. According to Zhang Zhengyou's method, the calibrated parameter is obtained, in which the parameter is used as the initial value. Then, taking the minimum mean error as the criterion, the improved seagull algorithm (SOA-SaDE) is used to establish the objective function, and the internal parameters and distortion coefficient of the camera are further solved. Verification experiments showed that the fusion algorithm has less reprojection error and higher calibration accuracy gull algorithm.
Spidroin-Based Biomaterials in Tissue Engineering: General Approaches and Potential Stem Cell Therapies
Authors: Zhang Qi , Li Min , Hu Wenbo , Wang Xin , Hu Jinlian
Published: December 2021

Spider silks are increasingly gaining interest for potential use as biomaterials in tissue engineering and biomedical applications. Owing to their facile and versatile processability in native and regenerated forms, they can be easily tuned via chemical synthesis or recombinant technologies to address specific issues required for applications. In the past few decades, native spider silk and recombinant silk materials have been explored for a wide range of applications due to their superior strength, toughness, and elasticity as well as biocompatibility, biodegradation, and nonimmunogenicity. Herein, we present an overview of the recent advances in spider silk protein that fabricate biomaterials for tissue engineering and regenerative medicine. Beginning with a brief description of biological and mechanical properties of spidroin-based materials and the cellular regulatory mechanism, this review summarizes various types of spidroin-based biomaterials from genetically engineered spider silks and their prospects for specific biomedical applications (e.g., lung tissue engineering, vascularization, bone and cartilage regeneration, and peripheral nerve repair), and finally, we prospected the development direction and manufacturing technology of building more refined and customized spidroin-based protein scaffolds.
Analysis of an Optimal Model for Liquidity Management of Financial Assets Using an Intelligent Scheduling Approach
Authors: Zhou Yi , Xia Weili , Peng Shengping
Published: December 2021

This paper adopts the intelligent scheduling method to conduct an in-depth study and analysis on the optimization of financial asset liquidity management model, elaborates and analyzes the liquidity risk management theory of commercial banks, and reviews the progress of liquidity risk management research in domestic and foreign academia as the theoretical basis of this paper. After that, we analyze the liquidity risk management of Anhui Tianchang Rural Commercial Bank from both qualitative and quantitative levels and further review and analyze the problems and causes. Finally, the full research is summarized and reviewed, theoretical and practical insights are discussed and analyzed, and future liquidity risk management research priorities and directions are elaborated. Based on the analysis results, the problems of the bank in liquidity risk management are described one by one, and further deep-seated cause discovery is carried out to summarize the problems of liquidity risk management which exist in the bank’s operation process due to the lack of liquidity risk management, unbalanced asset, and liability allocation, as well as weak emergency management capability, insufficient day-to-day liquidity monitoring, and lack of professional talents. For the problems and causes of the study, effective suggestions on how to strengthen the bank’s liquidity risk management in multiple aspects are proposed. It is hoped that, by improving the bank’s liquidity risk management and reducing the chance of liquidity risk occurrence, the bank’s sustainable development can be enhanced, and it is also hoped that it can provide some reference for the liquidity risk management of similar rural small- and medium-sized financial institutions.
Identification of the 7-lncRNA Signature as a Prognostic Biomarker for Acute Myeloid Leukemia
Authors: Liu Chun-yu , Guo Hui-hui , Li Hai-xia , Liang Ying , Tang Cong , Chen Nan-nan
Published: December 2021

A lot of evidence has emphasized the function of long noncoding RNAs (lncRNAs) in tumors’ development and progression. Nevertheless, there is still a lack of lncRNA biomarkers that can predict the prognosis of acute myeloid leukemia (AML). Our goal was to develop a lncRNA marker with prognostic value for the survival of AML. AML patients’ RNA sequencing data as well as clinical characteristics were obtained from the public TARGET database. Then, differentially expressed lncRNAs were identified in female and male AML samples. By adopting univariate and multivariate Cox regression analyses, AML patients’ survival was predicted by a seven-lncRNA signature. It was found that 95 abnormal expressed lncRNAs existed in AML. Then, the analysis of multivariate Cox regression showed that, among them, 7 (LINC00461, RP11-309M23.1, AC016735.2, RP11-61I13.3, KIAA0087, RORB-AS1, and AC012354.6) had an obvious prognostic value, and according to their cumulative risk scores, these 7 lncRNA signatures could independently predict the AML patients’ overall survival. Overall, the prognosis of AML patients could be predicted by a reliable tool, that is, seven-lncRNA prognostic signature.
Necrotizing Bacterial Myositis as the Initial Presentation of Severe Aplastic Anaemia
Authors: Rørvik Synne Dragesund , Larsen Kristoffer Stange , Helgeland Lars , Dale Håvard , Ivarsen Birgitta , Bruserud Øystein , Tvedt Tor Henrik Anderson
Published: December 2021

Introduction. Necrotizing soft tissue infections are rapidly progressing infections associated with severe inflammation and cytokine release. Early recognition and surgical intervention are key factors to secure survival. The current case presents a patient with multifocal necrotizing soft tissue infection as the initial presentation of severe aplastic anaemia. Case Presentation. A man in his fifties was admitted with septic shock with multiorgan failure and severe pancytopenia, after two days of malaise with high fever and right flank pain. The diagnosis streptococcal necrotizing myositis was significantly delayed due to atypical clinical findings. After initial surgical exploration, the decision was made to defer from surgical debridement due to extensive involvement of several muscle groups, grave pancytopenia, and suspected dismal prognosis. Surprisingly, the patient stabilized after antibiotics and intensive care treatment. Based on severe pancytopenia and hypocellular bone marrow, with no evidence of other bone marrow disorders, the patient was diagnosed with aplastic anaemia. Treatment for aplastic anaemia with antithymocyte globulin, cyclosporine, and eltrombopaq was started, and 2 months later, a partial haematological recovery was observed. The patient could be discharged from hospital without antibiotic treatment. Conclusions. This case illustrates the crucial role of a multidisciplinary approach on admission and further during the clinical course. Clinical improvement despite severe neutropenia and stabilization during immunosuppressive therapy suggest that immunological factors modulate clinical course in necrotizing soft tissue infections.
Relationship of Para and Perirenal Fat and High-Density Lipoprotein and Its Function in Patients with Type 2 Diabetes Mellitus
Authors: Ke Jing , Wang Yan , Liu Simo , Li Kun , Xu YueChao , Yang Longyan , Zhao Dong
Published: December 2021

Background. Para and perirenal fat is a fat pad surrounding the kidneys. Recent studies showed the association between para and perirenal fat and cardiovascular diseases including atherosclerosis and hypertension. We aimed to assess the relationship between para-perirenal ultrasonographic fat thickness and serum high-density lipoprotein (HDL) level and cholesterol efflux capacity of HDL in patients with type 2 diabetes mellitus (T2DM). Methods. We recruited 58 subjects with T2DM and collected anthropometric indices including height, weight, waist circumference, and other clinical data. Para-perirenal ultrasonographic fat thickness (PUFT) was measured via ultrasound. Serum lipid profile and other metabolic indices were determined as well. Correlation analysis and regression analysis were performed to analyze the relationship between PUFT and HDL level and cholesterol efflux capacity in all patients and subgroups. Results. Patients with higher PUFT have lower serum HDL level but increased cholesterol efflux capacity. Further analysis showed that PUFT negatively correlated with the serum HDL level in all patients, with no difference in groups divided by body mass index (BMI). In addition, PUFT was positively correlated with cholesterol efflux capacity in all patients. Multiple stepwise regression analysis showed an independent association of PUFT and serum HDL level and cholesterol efflux capacity. Conclusions. PUFT is closely correlated with the serum HDL level and cholesterol efflux capacity in patients with T2DM.
Remaining Useful Life Prediction of Quay Crane Hoist Gearbox Bearing under Dynamic Operating Conditions Based on ARIMA‐CAPF Framework
Authors: Sun Zhiwei , Hu Xiong , Dong Kai
Published: December 2021

The remaining useful life (RUL) prediction of quay crane (QC) bearings is of great significance to port production safety. An RUL prediction framework of QC bearing under dynamic conditions is proposed. Firstly, the load is discretized, and the corresponding operating conditions are classified. Then, the Autoregressive Integrated Moving Average (ARIMA) model is utilized to predict the load and corresponding operating conditions. Secondly, a Wiener process considering degradation rates and jump coefficients under different operating conditions is developed as the state transfer function. Finally, a condition‐activated particle filter (CAPF) is proposed to predict the system state and the bearing’s RUL. The proposed prediction framework is verified by the hoist bearing life cycle data from a port in Shanghai collected by the NetCMAS system. The prediction results by the ARIMA‐CAPF framework in comparison with three other prediction strategies identify the effectiveness.
The Influence Mechanism of In Situ Stress State on the Stability of Deep‐Buried‐Curved Tunnel in Qinghai‐Tibet Plateau and Its Adjacent Region
Authors: Wang Huiqing , Tan Chengxuan , Feng Chengjun , Zhang Peng , Qi Bangshen , Tan Zhangliang , Meng Jing , Guo Weijun
Published: December 2021

In China, rockburst disaster occurs mostly in construction of underground engineering in Qinghai‐Tibet Plateau and its adjacent region. Previous research on deep‐buried tunnels has indicated that tunnels stability is related to in situ stress state. To quantify these relationships, three‐dimensional finite element modeling was done to analyze the influences that the angle φ between the maximum horizontal principal stress orientation and tunnel axis, and the lateral pressure coefficient KH, had on the tangential stress σθ in a deep‐buried‐curved tunnel. Based on the in situ stress condition in Qinghai‐Tibet Plateau and its adjacent region, 50 different simulation conditions were used to analyze the relationship that φ and KH had on σθ for the rock mass surrounding the tunnel. With the simulation data produced, predictive equations were generated for σθ as a function of φ and KH using multivariate regression analysis. These equations help estimate σθ at various key positons along the tunnel boundary at Qinghai‐Tibet plateau and its adjacent region. The equations were then proved by a set of typical tunnels to ensure validity. The results concluded that the change in φ has a significant impact on σθ, and thus, the stability of the tunnel, when 30° < φ < 60°, with the most obvious influence being when φ is about 45°. With the equations, the rockburst potential at a certain location within a curved tunnel can be quickly estimated by calculating φ and KH on σθ, without need of geo‐stress background knowledge and heavy simulation, allowing for the practical value in engineering at design phase for the projects in Qinghai‐Tibet Plateau and its adjacent region.
Mechanism of miR-181a-5p in Regulatory T/T-Helper 17 Immune Imbalance and Asthma Development in Mice with Allergic Rhinitis
Authors: He Ruoyun , Chen Yujuan , Chen Xiaoer , Yuan Binfan
Published: December 2021

Introduction: Allergic rhinitis (AR) is an immune disorder and also a risk factor of asthma. microRNAs (miRNAs) are implicated in autoimmune diseases, including RA. This study investigated effect of miR-181a-5p on regulatory T (Treg)/ T-helper (Th) 17 immune imbalance in AR. Methods: A murine model of AR was established and treated with lentivirus modified miR-181a-5p. The allergic symptoms of mice were examined. The contents of Th17-related cytokines (interferon [IFN]-γ and interleukin [IL]-6), Treg-related cytokine (IL-10), and Treg-specific nuclear transcription factor (Foxp3) in nasal mucosa and lung tissues were determined. The proportion of Treg and Th17 cells was analyzed by flow cytometry. The level of ovalbumin-specific immunoglobulin E in the serum, and the contents of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid and IFN-γ, IL-6, and IL-10 in nasal lavage fluid were measured. The targeting relationship between miR-181a-5p and high mobility group box chromosomal protein 1 (HMGB1) was verified. HMGB1 and receptor for advanced glycation end products (RAGE) expression in RA were determined, and the interaction between HMGB1 and RAGE was detected. Results: miR-181a-5p expression was reduced in AR mice. miR-181a-5p overexpression attenuated allergic behaviors, alleviated Treg/Th17 imbalance, and delayed asthma development. HMGB1 and RAGE were elevated in AR mice. miR-181a-5p targeted HMGB1, and HMGB1 bound to RAGE, while miR-181a-5p overexpression reduced the binding between them. Activating HMGB1/RAGE reversed the protective effect of miR-181a-5p overexpression on AR and induced the development of asthma. Conclusion: miR-181a-5p overexpression reduced the binding of HMGB1 and RAGE by inhibiting HMGB1, thus alleviating Treg/Th17 immune imbalance and blocking AR from developing into asthma.
Benzodiazepine Use and Morbidity-Mortality Outcomes in a Geriatric Palliative Care Unit: A Retrospective Review
Authors: Senderovich Helen , Gardner Sandra , Berall Anna , Ganion Michael , Zhang Dennis , Vinoraj Danusha , Waicus Sarah
Published: December 2021

Introduction: Patients often experience delirium at the end of life. Benzodiazepine use may be associated with an increased risk of developing delirium. Alternate medications used in conjunction with benzodiazepines may serve as an independent precipitant of delirium. The aim is to understand the role of benzodiazepines in precipitating delirium and advanced mortality in palliative care population at the end of life. Methods: A retrospective medical chart review was conducted at a hospice and palliative care inpatient unit between the periods of June 2017–December 2017 and October 2017–November 2018. It included patients in hospice and palliative care inpatient units who received a benzodiazepine and those who did not. Patient characteristics, as well as Palliative Performance Scale score, diagnosis, and occurrence of admission, terminal, and/or recurrent delirium, were collected and analyzed. Results: Use of a benzodiazepine was not significantly associated with overall mortality nor cause-specific death without terminal delirium rate. However, it was significantly associated with higher cause-specific death with terminal delirium rate and a higher recurrent delirium rate. Discussion: This retrospective chart review suggests an association between benzodiazepine use and specific states of delirium and cause-specific death. However, it does not provide strong evidence on the use of this drug, especially at the end of life, as it pertains to the overall mortality rate. Suggested is a contextual approach to the use of benzodiazepines and the need to consider Palliative Performance Scale score and goals of care in the administration of this drug at varying periods during patient length of stay.
Association between Cardiac Outcomes and Indoxyl Sulfate Levels in Hemodialysis Patients: A Cross-Sectional Study
Authors: Li Zhuo , Ke Guibao , Song Li , Huang Junlin , Zhang Yamei , Xiao Jie , Liu Shuangxin , Liang Xinling
Published: December 2021

Objective: Indoxyl sulfate (IS) is a protein-bound uremic toxin that is associated with cardiovascular events and mortality in hemodialysis (HD) patients. However, the factors affecting the levels of IS are currently unclear. This study aimed to investigate the factors influencing serum IS concentrations in HD patients. Methods: We included 100 HD patients from Guangdong Provincial People’s Hospital. Baseline characteristics, including sex, age, clinical features, duration of HD, echocardiography findings, electrocardiogram results, and biochemical indicators, were collected and analyzed in relation to serum total-form IS levels. Results: Among all 100 patients, serum IS levels were significantly higher in patients aged ≥60 years, males, and patients with mitral regurgitation and inadequate dialysis. Among patients aged <60 years, IS levels were significantly higher among patients with mitral regurgitation compared with those without. Furthermore, multiple linear regression analysis identified sex, age, ventricular septal thickness, and mitral regurgitation as factors independently associated with serum IS (STDβ = −0.475, 0.162, −0.153, 0.142, and 0.136, respectively; all p < 0.05) adjusted for body mass index, smoking, and fasting plasma glucose. Conclusions: Male sex, age ≥60 years, ventricular septal thickness, and mitral regurgitation are factors associated with high total serum IS concentrations in Chinese HD patients. Elevated IS levels may play a role in the process of mitral regurgitation in HD patients <60 years of age.
PELARGONIUM SIDOIDES, HEDERA HIBERNICA ТА ORIGANUM VULGARE В СКЛАДІ ФАРМАЦЕВТИЧНИХ ПРЕПАРАТІВ ПРЕДСТАВЛЕНИХ НА РИНКАХ УКРАЇНИ ТА ПОЛЬЩІ
Authors: Bryda O. R. , Stadnytska N. Ye.
Published: December 2021

Мета роботи. Провести аналіз асортименту лікарських препаратів фармацевтичних ринків України та Польщі, які містять в своєму складі субстанції коренів пеларгонії очиткової (Pelargonium Sidoides), трави материнки звичайної (Origanum vulgare) та листя плюща звичайного (Hedera Hibernica). На підставі одержаних результатів визначити доцільність розробки нового багатокомпонентного препарату з їхнім вмістом.
Матеріали і методи. Аналіз фармацевтичних ринків проводили згідно з даними Державного реєстру лікарських засобів України та Польщі (станом на липень 2021 року). Робота виконана з використанням логічного, статистичного та графічного методів.
Результати й обговорення. Більшість проаналізованих засобів фармацевтичних ринків України та Польщі із вмістом пеларгонії очиткової, материнки звичайної, плюща звичайного представлені у формі сиропів. В основному, це однокомпонентні лікарські засоби (73,33 % в Україні та 91,7 % в Польщі). В обох країнах найбільший відсоток досліджуваних препаратів вироблені на вітчизняних фармацевтичних підприємствах, на другому місці препарати імпортовані з Німеччини. Найчастіше лікарські препарати із вмістом Origanum vulgare, Hedera Hibernica, Pelargonium Sidoides – це засоби, що застосовуються у разі кашлю та застудних захворювань (78,21 %).
Висновки. Розробка нового багатокомпонентного лікарського засобу із вмістом трави материнки, листя плюща і пеларгонії є перспективною оскільки аналогів такого препарату  на проаналізованих фармацевтичних ринках немає.