bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolic pathways and gene expression changes in Amblyseius orientalis Ehara (Acari: Phytoseiidae): The role of host plant nutrients in predator-pest dynamics
Authors: Zhang Yannan , Kalmosh Fatma Sh. , Sheng Fujing , Wang Endong , Lv Jiale , Xu Xuenong
Published: November 2024

Amblyseius orientalis Ehara (Acari: Phytoseiidae) is one local predatory mite in China that has high potential for controlling Polyphagotarsonemus latus, a globally important pest to many vegetables and crops. To further evaluate the control potential of A. orientalis on different host plants against P. latus, we selected bean, cucumber, and pepper as host plants to feed P. latus, and then to feed A. orientalis. It was found when the prey P. latus fed on cucumber leaves, development of A. orientalis was the slowest, with the lowest egg production and overall poor biological performance. When A. orientalis was fed with prey hosted on cucumber and the other two plants, there were 119 differentially expressed organic compounds. The differentially metabolites were significantly enriched in the pentose phosphate pathway and carbon metabolism pathway. Further transcriptomic analysis of A. orientalis revealed 36 differentially expressed genes. Among these genes, 20 were annotated in 17 pathways in KEGG, with significant enrichment in hippo signaling pathway-fly and polysaccharide degradation pathways detected. These results indicate that the development and reproduction of A. orientalis are significantly poorer when feeding on P. latus, leading to a marked decline in amino acids, sugars, lipids, and organic compounds in A. orientalis. Additionally, there are 36 genes with consistently different expression patterns in A. orientalis when comparing cucumbers to the other two host plants. This study is an initial attempt to unravel the biological mechanisms of how nutritional substances might affect biology of natural enemies through the food chain.
Deep water characteristics of electrodynamic transducers based on distributed-parameter equivalent circuit of acoustic cavity
Authors: Sang Yongjie , Zhang Yishuang , Wu Shuai
Published: November 2024

The source level of the electrodynamic transducer with a passive pressure compensation airbag in ultra-low frequencies (bands below 100 Hz) decreases sharply with the increase in working depth. A theoretical model with a distributed-parameter equivalent circuit of the acoustic cavity was proposed to explore the mechanism of this phenomenon and find a way to improve the ultra-low frequency source level in deep water (over 200 m). The results indicate that the decrease in acoustic compliance of the cavity in deep water leads to an increase in resonant frequency, resulting in a decrease in source level in the ultra-low frequency band. The resonance frequency in deep water shows differences based on distributed and lumped parameter models. The resonance frequency test results of the prototype show that the theoretical results based on a distributed-parameter model proposed in this study are more consistent with the test values. The effects of the acoustic cavity's structural size, the acoustic parameters of the gas in the cavity, and the active pressure compensation method on the source level at different depths were analyzed. Results reveal that the acoustic performance in ultra-low frequency bands at large depths can be markedly improved using the active pressure compensation method.
The challenges of difficult-to-treat
Acinetobacter
infections
Authors: Richards Guy A. , Perovic Olga , Brink Adrian J.
Published: November 2024

Infections due to
Acinetobacter
spp. are among the most difficult to treat. Most are resistant to standard antibiotics, and there is difficulty in distinguishing colonizers from pathogens. This mini-review examines the available antibiotics that exhibit activity against these organisms and provides guidance as to which cultures are relevant and how to treat active infections. Antibiograms describing resistance mechanisms and the minimum inhibitory concentration (MIC) are essential to determine which agent or combination of agents should be used after confirmation of infection, utilizing clinical parameters and biomarkers such as procalcitonin. Directed therapy should be prompt as despite its reputation as a colonizer, the attributable mortality is high. However, although combination therapy is advised, no specific combination has definite evidence of superiority.
A simplified pyrazinamidase test for
Mycobacterium tuberculosis
pyrazinamide antimicrobial susceptibility testing
Authors: Chan Hsin-Hua , Wang Yu-Chen , Jou Ruwen
Published: November 2024

Pyrazinamide (PZA) is an important first-line drug for tuberculosis (TB) treatment by eradicating the persisting
Mycobacterium tuberculosis
complex (MTBC). Due to cost and technical challenges, end TB strategies are hampered by the lack of a simple and reliable culture-based PZA antimicrobial susceptibility testing (AST) for routine use. We initially developed a simplified chromogenic pyrazinamidase (PZase) test in the TB reference laboratory using a training set MTBC isolates with various drug-resistant profiles, and validated its performance using consecutive BACTEC MGIT 960 (MGIT)-culture-positive culture in 10 clinical laboratories. The
pncA
gene Sanger sequencing results were used as the reference, and compared to the MGIT-PZA AST. Differential diagnosis of
Mycobacterium bovis
was conducted using patented in-house real-time PCR. Of the 106 training isolates, the PZase test and MGIT-PZA AST showed 100.0% and 99.1% concordance as compared to Sanger sequencing, respectively. We found 32.1% (34/106) isolates harbored
pncA
mutations, including one isolate with silent mutation S65S. For validation, 1,793 clinical isolates were tested including 150 duplicate isolates from specimens of the same cases and 16 isolates with uncharacterized drug resistance (UDR)-associated mutations. Excluding duplicated and UDR isolates, we identified 2.6% (43/1,627) PZA-resistant isolates, including 1.3% (21/1,627)
M
.
bovis
isolates. The kappa values were 0.851–1.000. In addition, the accuracy of the PZase test conducted by 10 laboratories was 98.5%–100.0%. Our simplified PZase test demonstrated high concordance with Sanger sequencing and MGIT-PZA AST. Integrating the PZase test into routine first-line AST is effortless and represents an improvement in laboratory services for ending TB.

IMPORTANCE

We developed and validated a simple pyrazinamidase (PZase) test for pyrazinamide (PZA) antimicrobial susceptibility testing (AST). Our results demonstrated that the PZase test had high agreement with the
pncA
gene sequencing and MGIT-PZA AST. Integrating PZase test into routine AST is effortless and represents an improvement in laboratory services for ending TB.
Hyaluronan in COVID-19: a matrix for understanding lung disease
Authors: Dodd Rebecca J. , Allen Judith E. , Day Anthony J.
Published: November 2024

The polysaccharide hyaluronan (HA) is an important component of lung extracellular matrix that increases following infection with influenza or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hellman et al. (U. Hellman, E. Rosendal, J. Lehrstrand, J. Henriksson, et al., mBio 15:e01303-24,
https://doi.org/10.1128/mbio.01303-24
) show that fragmented HA accumulates in the lungs of coronavirus disease 2019 (COVID-19) patients, with systemic levels of HA being associated with reduced lung function 3–6 months after infection. This study provides novel insights into HA’s role in COVID-19 pathology and its potential utility as a biomarker for disease severity. However, much remains to be understood about the lung HA matrix in COVID-19 and how it compares to other lung conditions. In particular, the role of HA-binding proteins in organizing HA into a crosslinked network is yet to be fully determined at a molecular level. This knowledge is crucial in understanding the inter-relationships between the structure of the HA matrix and the regulation of the immune response, and thus our ability to target HA therapeutically for improved outcomes in COVID-19.
Reflective Properties of Black Silicon in a Wide Spectral Range
Authors: Ayvazyan G. Y.
Published: November 2024

The structural and reflective properties (total reflectance and scattering) of black silicon layers formed by reactive ion etching have been studied. Reflectance spectra were determined in the visible, near-infrared, and near-ultraviolet wavelength ranges. The influence of etching duration on the optical behavior of black silicon layers is studied and the possibilities of their use in solar cells and photodetectors are discussed.
Protocol for a randomised, double-blinded, controlled trial of youth with childhood-onset obesity treated with semaglutide 2.4 mg/week: the RESETTLE trial
Authors: Byberg Sarah , Holt Joachim , Sandsdal Rasmus Michael , Holm Louise Aas , Madsen Lærke Bruun , Christensen Bodil Just , Jensen Simon Birk Kjær , Hansen Torben , Holm Jens-Christian , Torekov Signe
Published: November 2024

Introduction

Childhood-onset obesity poses significant health risks, including early-onset type 2 diabetes, cardiovascular disease, and reduced quality of life. Hospital-based non-pharmacological obesity care can reduce childhood obesity, but 25% of children do not respond. Therefore, this study investigates the effect of the glucagon-like peptide-1 receptor agonist, semaglutide, as an add-on to hospital-based obesity care in youth who still have obesity following hospital-based obesity care as children. Furthermore, biomedical and psychosocial factors linked to treatment response will be investigated, alongside an exercise-based strategy to prevent weight regain and maintain a healthy body composition after semaglutide treatment.

Methods and analysis

This is an investigator-initiated, randomised, placebo-controlled, double-blind trial. We will enrol expectedly 180–270 young adults aged 18–28 years based on their previous response to a paediatric obesity management programme and their current body mass index (BMI). Participants are categorised into four groups: low treatment response (BMI SD score (SDS) reduction <0.10; BMI ≥30 kg/m2); medium treatment response (BMI SDS reduction >0.25; BMI ≥30 kg/m2); high treatment response (BMI SDS reduction >0.50; BMI <30 kg/m2) and a population-based reference group with normal weight development in childhood. Participants with BMI ≥30 kg/m2are randomised 2:1 to subcutaneous injections of semaglutide 2.4 mg/week or placebo as an add-on to hospital-based obesity care for 68 weeks. The primary outcome is the change in BMI from randomisation to the end of treatment with semaglutide compared with placebo. Secondary endpoints are changes in weight and body composition.

Ethics and dissemination

The trial has been approved by the Danish Medicines Agency and the Ethical Committee of the Capital Region of Denmark (H-20039422). The trial will be conducted in accordance with the Declaration of Helsinki and follow the guidelines for Good Clinical Practice. Results will be presented at international scientific conferences and published in peer-reviewed scientific journals.

Trial registration number

EudraCT 2019-002274-31.
Modifiable factors for somatic symptom persistence in patients with somatic symptom disorder: study protocol for a longitudinal cohort with an embedded ecologically momentary assessment (SOMA.SSD)
Authors: Nestoriuc Yvonne , Pauls Franz , Blankenburg Kristina , Hahn Stefanie , Wittenbecher Henrike , Löwe Bernd , Toussaint Anne
Published: November 2024

Introduction

Somatic symptom disorder (SSD) is a distressing mental disorder characterised by the presence of at least one persistent somatic symptom and a significant psychological burden due to the symptom(s), as well as excessive thoughts, feelings or behaviours related to them or associated health concerns. The primary aim of our study is to deepen the understanding of risk factors and mechanisms for somatic symptom persistence. Specifically, we will investigate the role of patients’ expectations and somatic comorbidity regarding symptom persistence.

Methods and analysis

In a prospective 12-month cohort study, n=240 patients with SSD will be recruited from the outpatient clinics of the Department of Psychosomatic Medicine and Psychotherapy at the University Medical Center Hamburg-Eppendorf. The roles of two hypothesised predictors (ie, expectations and comorbidity) will be analysed together with known predisposing and maintaining factors of persistent somatic symptoms. The study entails macrolevel and microlevel assessments to investigate symptom severity over different timespans. Assessments at the macrolevel take place at baseline, 6 and 12 months. At the microlevel, a 10-day ecological momentary assessment study will be implemented to elucidate patients’ dynamic experience with somatic symptoms in their natural environments. In order to elicit possible framing effects on the 10-day course of symptom severity, participants are randomised to either a positive or a negative expectation framing group. Cross-lagged panel models will be used to analyse data at the macrolevel. At the microlevel, multivariate latent growth curve models will be conducted to relate temporal changes in predictor and outcome variables to one another.

Ethics and dissemination

The study was approved by the Ethics Committee of the Medical Associations Hamburg, Germany (2020-10197-BO-ff). The results will enable us to draw conclusions regarding the role of expectations for future targeted treatment options and regarding the utility of somatic comorbidity as a potential diagnostic specifier of SSD. Dissemination of our results will be achieved through scientific publications, and lay summaries for study participants, patient advocacy groups and the general public.

Trial registration number

ISRCTN36251388.
Variability of quality-of-life measurements and reporting in randomised controlled trials of pancreatic cancer: a systematic review
Authors: Tushoski-Alemán Gerik W , Crespin Alexandra J , Oguejiofor Chibeze J , Szymkiewicz Dominique D , Herremans Kelly M , Han Song , Hughes Steven J
Published: November 2024

Objectives

This systematic review aims to evaluate the methodology used in pancreatic cancer (PC) randomised controlled trials (RCTs) measuring quality of life (QOL) and focuses on the type, frequency, survey compliance and duration of these assessments.

Design

Systematic review of PC RCTs measuring QOL.

Data sources

A search of PubMed.gov and ClinicalTrials.gov was conducted for PC RCTs measuring QOL from inception to 21 March 2023. Only phase III RCTs were included. Studies were excluded if QOL was not measured, the study was phase I/II, in the second-line setting or unavailable in English. Data were independently extracted by two reviewers in a standardised fashion.

Primary and secondary outcome measures

Primary outcomes included the type of QOL instrument used, the timing and frequency of assessments, methods of analysis and survey completion rates (SCRs) over time. Secondary outcomes included patient demographics, significant QOL improvements and the frequency of trials measuring QOL.

Results

Out of 269 studies screened, 54 RCTs were identified, and 24 measured QOL (involving 11 229 patients). Instruments used included the EORTC QLQ-C30 (n=15), FACT-HEP (n=3), Spitzer-QOL-Index (n=2), EQ-5D (n=2), LASA (n=1) and FACT-PA (n=1). Most trials assessed QOL until disease progression or death (10/24), with 4-week intervals being the most common (7/24). SCRs were reported in 15/24 trials, with disease stage influencing SCRs over time. In trials with metastatic, locally advanced/metastatic, and resectable disease, the median times to reach a 50% response rate—defined as the point where the number of surveys completed was half of the enrolled participants—were 12.41 weeks (n=2), 14.14 weeks (n=10), and 54.2 weeks (n=3), respectively.” Only 2/24 trials reported significant QOL improvements between treatment arms. Patient age was reported in all trials, while race/ethnicity was only reported in 4/24 trials.

Conclusions

Significant variability exists in the timing, methods and reporting of QOL assessments in PC trials. There is a need for further research to assess the implications of missing data and consider the temporality of QOL assessment in patients with advanced cancers and poor prognosis.
Effects of low-dose aspirin in bipolar disorder: study protocol for a randomised controlled trial (the A-Bipolar RCT)
Authors: Bruun Caroline Fussing , Zarp Jeff , Lyng Forman Julie , Coello Klara , Miskowiak Kamilla Woznica , Vinberg Maj , Faurholt-Jepsen Maria , Kessing Lars Vedel
Published: November 2024

Introduction

Accumulating data support the association between increased inflammation and bipolar disorder (BD), and preliminary data suggest that augmentation with low-dose aspirin (LDA) may protect against the onset and deterioration of BD via anti-inflammatory pathways. The A-bipolar randomised controlled trial (RCT) aims to investigate whether adding LDA to standard treatment improves day-to-day mood instability (MI) in BD.

Methods and analysis

A two-arm, triple-blind, parallel-group, superiority RCT including 250 patients with newly diagnosed BD treated at the Copenhagen Affective Disorder Clinic, Denmark. Participants are randomised 1:1 to either 150 mg of acetylsalicylic acid daily (LDA) or a placebo for six months in addition to their regular treatment. Mood instability, calculated from daily smartphone-based mood evaluations, is the primary outcome measure due to its internal validity as a real-life measure for patients and external validity as it reflects patients’ illness severity and functioning. Analyses will be conducted as intention-to-treat analyses using a linear mixed model including time (categorical) and the time–treatment interaction as fixed effects and with an unstructured covariance pattern to account for repeated measurements on each study participant. The trial is Good Clinical Practice monitored.

Ethics and dissemination

The Danish Research Ethics Committee (H-21014515) and the data agency, Capital Region of Copenhagen (P-2021-576) approved the trial. Results will be published in peer-reviewed journals.

Trial registration number

NCT05035316.
Non-surgical treatment for tandem spinal stenosis: a systematic review protocol
Authors: Liu Xu Hao , Dong Yuan Wei , Gou Xin , Yang Xiao Long , Zou Jin Wen , Liu Xin , Zhong Lei , Fang Hong Xia
Published: November 2024

Background

Tandem Spinal Stenosis (TSS) is a disease characterised by the narrowing of the spinal canal in two or more non-adjacent areas of the spine, often affecting both the cervical and lumbar vertebrae. Doctors and patients increasingly favour non-surgical treatments that have the function of relieving symptoms and improving outcomes. This systematic review aims to evaluate the effectiveness and safety of non-surgical therapies for TSS and comprehensively summarise existing evidence.

Methods and analysis

We will conduct comprehensive searches, both manual and electronic, of literature published up to 30 September 2024; database searches will commence after the publication of this agreement, with an estimated commencement date of 1 December 2024, and the end date is 31 May 2025, without language restrictions. Key databases such as MEDLINE, PubMed, EMBASE, Web of Science, Cochrane Library, WHO International Clinical Trial Registration Platform, China National Knowledge Infrastructure, China Biomedical Literature Database, China Scientific Journal Database and Wan-Fang Database will be explored. In addition, we will include resources such as library journals and conference abstracts. Following the identification and screening of all randomised controlled trials focusing on non-surgical treatments for TSS, two investigators will perform a meta-analysis of the included studies. The findings will be summarised as the risk ratio for binary data and the standardised or weighted mean difference for continuous data.

Ethics and dissemination

Ethical approval is not required, as the review does not involve individual patient data. The review’s findings will provide clinicians with evidence on using non-surgical treatments for TSS, disseminated through peer-reviewed publications or conferences.

PROSPERO registration number

CRD42024496634.
Does serum neutrophil gelatinase–associated lipocalin level predict acute kidney injury in patients with acute rhabdomyolysis in the emergency department? A multicentre prospective study
Authors: Pommet Stephane , Coisy Fabien , Demattei Christophe , Balaguer Lucille , de Bauwere David-Paul , Grau-Mercier Laura , Markarian Thibaut , Bobbia Xavier , Genre Grandpierre Romain
Published: November 2024

Objectives

The major complication of rhabdomyolysis is acute kidney injury (AKI), which requires prompt treatment. Currently, few biomarkers are available for the early detection of AKI. Serum neutrophil gelatinase–associated lipocalin (NGAL) has been suggested as an early biomarker for renal ischemia. However, its capacity to predict AKI in patients presenting with rhabdomyolysis in the emergency department (ED) remains unclear. The aim of this study was to evaluate the ability of NGAL to predict 48-hour AKI.

Design

Prospective, multicentre study.

Setting

Five adult EDs in France from August 2013 to December 2015.

Participants

NGAL levels were measured on ED admission in patients with rhabdomyolysis. A total of 197 patients were enrolled, and 189 (96%) were analysed, of whom 89 (47%) were women. Patients were included if they presented to the ED with rhabdomyolysis and a creatine phosphokinase (CPK) level above 1000 IU/L. Exclusion criteria were pregnancy, presentation with acute coronary syndrome, the need for iodinated contrast, chronic dialysis or recent use of nephrotoxic drugs (within 72 hours prior to the ED visit). Patients who withdrew consent or had AKI due to other causes were also excluded.

Primary and secondary outcome measures

The primary outcome was AKI at 48 hours, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Secondary outcomes included in-hospital mortality, length of hospital stay, admission to intensive care and the need for renal replacement therapy.

Results

Overall, 54 (29%) patients developed AKI by day 2. The area under the ROC curve (AUC-ROC) for NGAL in predicting AKI on day 2 was 0.60 (95% CI 0.51 to 0.70), with an optimal cut-off of 129 ng/mL. The sensitivity was 0.65, and specificity was 0.50. After adjustment for CPK levels, age, sex and oxygen saturation, the AUC-ROC for predicting AKI on day 2 increased slightly to 0.64 (95% CI 0.54 to 0.74).

Conclusion

NGAL has limited ability to predict day 2 AKI in patients presenting with acute rhabdomyolysis in the ED.

Trail registration number

NCT01544231.

Comité de Protection des Personnes Sud Méditerranée III n°2011-A01059-32.
An uncertain future: perspectives of emerging adults with inflammatory bowel disease—a qualitative semistructured interview study in eastern China
Authors: Zhou Yu , Qiao Ranran , Ding Tengteng , Li Hui , Zhang Ping
Published: November 2024

Objective

For emerging adults with inflammatory bowel disease, future uncertainty is a critical issue during this pivotal stage of life, study and career development, as they encounter many unknown challenges and opportunities. However, to the best of our knowledge, only a few qualitative studies on how emerging adults with inflammatory bowel disease cope with these uncertainties exist. This study aimed to investigate uncertainties associated with the future of emerging adults with inflammatory bowel disease and explore coping strategies.

Design

A qualitative semistructured interview study with a phenomenological approach. Face-to-face semistructured interviews were conducted, audio-recorded, transcribed verbatim and subsequently analysed using the Colaizzi seven-step analysis method.

Setting

A tertiary hospital in eastern China.

Participants

Participants (n=14) were emerging adults with inflammatory bowel disease recruited from a tertiary hospital in eastern China, using a purposeful sampling technique.

Results

Fourteen patients completed the interviews. Four themes were identified: uncertainties in educational and vocational planning, social and interpersonal relationships, mental and emotional health and disease management. Moreover, the participants emphasised the significance of timely patient education postdiagnosis and ensuring consistent medical guidance after discharge to minimise uncertainty and alleviate confusion. They also hoped to manage the disease through traditional Chinese medicine.

Conclusions

This study provides valuable insights into the various challenges encountered by emerging adults with inflammatory bowel disease and the factors that may impact their experiences. Additionally, it suggests the need for healthcare providers to devise suitable support and intervention strategies to guide and establish stable management of the patients’ uncertain futures.

Trial registration number

ChiCTR2300071289.
Dynamics of massive and massless particles in the spacetime of a wiggly cosmic dislocation
Authors: dos S. Azevedo Frankbelson , Silva Edilberto O.
Published: November 2024

In this paper, we investigate the spacetime containing both small-scale structures (wiggles) and spatial dislocation, forming a wiggly cosmic dislocation. We study the combined effects of these features on the dynamics of massive and massless particles. Our results show that while wiggles alone lead to bound states and dislocation introduces angular momentum corrections, their coupling produces more complex effects, influencing both particle motion and wave propagation. Notably, this coupling significantly modifies radial solutions and eigenvalues, with the direction of motion or propagation becoming a critical factor in determining the outcomes. Numerical solutions reveal detailed aspects of particle dynamics as functions of dislocation and string parameters, including plots of trajectories, probability densities, and energy levels. These findings deepen our understanding of how a wiggly cosmic dislocation shapes particle dynamics, suggesting new directions for theoretical exploration in cosmological models.
Embedded System Security Protocols: Latest Trends and Issues
Authors: Han Huimin , Gulzar Yonis , Nizamani Ahsan Ahmed , Nizamani Abdul Haseeb , Ali Sijjad , Bhatti Mughair Aslam
Published: November 2024

Given the increasingly serious security threats faced by embedded systems, an analysis has been conducted on the characteristics and vulnerabilities of embedded systems. Detailed discussions are provided on security threats faced by embedded systems from two major aspects: hardware-based attacks such as side-channel attacks, hardware Trojans, fault injection, microprobes, and hardware reverse engineering, and software attacks aimed at damaging, tampering, and stealing. The analysis includes existing security measures both domestically and internationally, highlighting their shortcomings. Based on the concept of trusted computing, the paper offers future research suggestions from several perspectives, including theoretical research models, trusted measurement, trusted reporting, trusted sharing, and isolation of resources. Finally, an ideal comprehensive joint security enhancement scheme is proposed, and future research directions are discussed.
Analysis of Economic Development Mechanism Based on Stochastic Dynamic Optimization Algorithm
Authors: Wang Cuilan
Published: November 2024

With the continuous improvement of China’s economic level, the research of economic data management has been paid more and more attention. As the high-tech industry plays an increasingly important role in the world economy, it has become a strategic highland for all countries in the world. How to design an economic data management model that integrates data mining techniques to achieve deep data mining and efficient utilization has become a research focus. In order to study the technical selection model of economic data, a new economic data management model based on a data mining algorithm is proposed. In the study of economic management data, the optimization model of data management is designed based on computer technology. In the optimization of data classification, a data mining algorithm is adopted to fully realize the reasonable management of data. According to the principle of the Random Dynamic Optimization Algorithm, the algorithm is improved, and its convergence speed is accelerated. The improved algorithm is applied to solve the one-dimensional cutting problem. Compared with other algorithms, the conversion method greatly improves the utilization rate of raw materials. Then, the efficiency and adaptability of the algorithm are tested by determining the algorithm and applying it to the knapsack problem.
The Impact of Drawing Systems Based on Embedded Neural Network Computing on Student Mental Health
Authors: Li Huihong
Published: November 2024

With the rapid development of artificial intelligence technology, embedded neural networks, as their core components, have shown enormous potential for application in multiple fields due to their powerful data processing and pattern recognition capabilities. In the field of painting education, the application of this technology can not only achieve customized teaching plans, but also intelligently analyze the characteristics of students’ behavioral works. This study focuses on the application of embedded neural network computing in painting teaching. Especially how to dynamically adjust the difficulty, style preferences, and interactive methods of teaching content to stimulate students’ creativity and learning interest. By intelligently analyzing students’ emotional reactions and psychological states, timely adjusting teaching strategies, such as providing emotional support, adjusting learning pace, or introducing psychological counseling content, can alleviate students’ learning pressure, and enhance their self-efficacy and sense of belonging. In addition, this technology can promote effective communication between teachers and students, establish more positive and harmonious teaching relationships, and create a more inclusive and encouraging learning environment for students. The research results indicate that compared to traditional painting teaching models, the teaching method based on embedded neural networks significantly improves the mental health level of students, which is manifested in the reduction of anxiety and depression, enhancement of self-confidence, and improvement of social skills.
AT-DBN: A Novel Deep Learning Approach for Accurate Flue Gas Pressure Forecasting in Power Plants
Authors: Xu Wei , Zhou Ti , Wang Yong , Wang Naibin , Qin Pan , Li Guoqing , Zhu Yiyao
Published: November 2024

Accurately predicting and controlling the flue gas pressure at the induced draft fan inlet is crucial for environmental protection and boiler efficiency. This study designed a model of Attention-enhanced Deep Belief Network (AT-DBN) to predict the flue gas pressure parameters at the induced draft fan inlet, based on key improvements to the Deep Belief Network (DBN). The main improvement involves introducing an attention mechanism to enhance the prediction accuracy of the model for the flue gas pressure parameters at the induced draft fan inlet. The study begins with meticulous preprocessing of historical operational data, including identifying and removing outliers to ensure data quality for subsequent analysis. Next, Pearson correlation analysis is employed to systematically evaluate the correlation between various variables and the flue gas pressure, thereby identifying key variables that significantly affect prediction performance. Finally, an attention mechanism is integrated into the traditional DBN architecture, aiming to enhance the network’s ability to perceive important information within the input features, thereby improving prediction accuracy and model generalization. The results demonstrate that the proposed AT-DBN model can accurately predict the flue gas pressure at the induced draft fan inlet across multiple test sets, providing valuable guidance for power plant production operations.
Great Transition in India: A Multidisciplinary Perspective
Authors: KIM CHANWAHN , KUMAR RAJIV
Published: November 2024

This special issue is part of an ongoing project by the Institute of Indian Studies at Hankuk University of Foreign Studies, titled Great Transitions in India: A Korean Perspective on Indian Studies. Launched in 2017 with the support of a significant research grant from the National Research Foundation of Korea (NRF) under the prestigious Humanities Korea Plus (HK[Formula: see text]) program, the project aims to explore India’s major transformations from a multidisciplinary viewpoint. Building on the momentum of the Journal of Indian and Asian Studies (JIAS) special issue series introduced in 2021, which focused on key changes in India, this issue continues that exploration. It brings fresh insights by integrating perspectives from the humanities and social sciences. This special issue is the result of an international conference on Great Transitions in India, held in May 2024 at the Institute of Indian Studies, Hankuk University of Foreign Studies, Seoul. The conference gathered scholars from various disciplines, each contributing to a broader understanding of India’s profound changes. By offering a multidisciplinary perspective, this issue seeks to advance the current body of literature and encourage scholars of Indian and South Asian studies to adopt cross-disciplinary approaches, fostering deeper insights into India’s transformations.
Supplementary Information from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Information including supplementary materials and methods and supplementary tables
Figure S7+legend from Targeting Galectin-1 Overcomes Paclitaxel Resistance in Esophageal Squamous Cell Carcinoma
Authors: Zhou Liting , Tian Jie , Wang Keke , Ma Yijie , Chen Xiaojie , Luo Hui , Lu Bingbing , Wang Nan , Wang Penglei , Liu Xuejiao , Zhao Ran , Zhao Simin , Wang Jiutao , Nie Wenna , Ge Hong , Liu Wenting , Gu Tingxuan , Liu Kangdong , Lee Mee-Hyun , Li Xiang , Dong Zigang
Published: November 2024

Figure S7+legend
Figure S6+legend from Targeting Galectin-1 Overcomes Paclitaxel Resistance in Esophageal Squamous Cell Carcinoma
Authors: Zhou Liting , Tian Jie , Wang Keke , Ma Yijie , Chen Xiaojie , Luo Hui , Lu Bingbing , Wang Nan , Wang Penglei , Liu Xuejiao , Zhao Ran , Zhao Simin , Wang Jiutao , Nie Wenna , Ge Hong , Liu Wenting , Gu Tingxuan , Liu Kangdong , Lee Mee-Hyun , Li Xiang , Dong Zigang
Published: November 2024

Figure S6+legend
Figure S5+legend from Targeting Galectin-1 Overcomes Paclitaxel Resistance in Esophageal Squamous Cell Carcinoma
Authors: Zhou Liting , Tian Jie , Wang Keke , Ma Yijie , Chen Xiaojie , Luo Hui , Lu Bingbing , Wang Nan , Wang Penglei , Liu Xuejiao , Zhao Ran , Zhao Simin , Wang Jiutao , Nie Wenna , Ge Hong , Liu Wenting , Gu Tingxuan , Liu Kangdong , Lee Mee-Hyun , Li Xiang , Dong Zigang
Published: November 2024

Figure S5+legend
Supplementary Figure S5 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S5
Supplementary Figure S3 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S3
Figure S2+legend from Targeting Galectin-1 Overcomes Paclitaxel Resistance in Esophageal Squamous Cell Carcinoma
Authors: Zhou Liting , Tian Jie , Wang Keke , Ma Yijie , Chen Xiaojie , Luo Hui , Lu Bingbing , Wang Nan , Wang Penglei , Liu Xuejiao , Zhao Ran , Zhao Simin , Wang Jiutao , Nie Wenna , Ge Hong , Liu Wenting , Gu Tingxuan , Liu Kangdong , Lee Mee-Hyun , Li Xiang , Dong Zigang
Published: November 2024

Figure S2+legend
Figure S1+legend from Targeting Galectin-1 Overcomes Paclitaxel Resistance in Esophageal Squamous Cell Carcinoma
Authors: Zhou Liting , Tian Jie , Wang Keke , Ma Yijie , Chen Xiaojie , Luo Hui , Lu Bingbing , Wang Nan , Wang Penglei , Liu Xuejiao , Zhao Ran , Zhao Simin , Wang Jiutao , Nie Wenna , Ge Hong , Liu Wenting , Gu Tingxuan , Liu Kangdong , Lee Mee-Hyun , Li Xiang , Dong Zigang
Published: November 2024

Figure S1+legend
Supplementary Figure S2 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S2
Supplementary Figure S19 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S19
Supplementary Figure S18 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S18
Supplementary Figure S16 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S16
Table S2 Genes per cluster from PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Authors: Spear Sarah , Le Saux Olivia , Mirza Hasan B. , Iyer Nayana , Tyson Katie , Grundland Freile Fabio , Walton Josephine B. , Woodman Chloé , Jarvis Sheba , Ennis Darren P. , Aguirre Hernandez Carmen , Xu Yuewei , Spiliopoulou Pavlina , Brenton James D. , Costa-Pereira Ana P. , Cook David P. , Vanderhyden Barbara C. , Keun Hector C. , Triantafyllou Evangelos , Arnold James N. , McNeish Iain A.
Published: November 2024

Genes upregulated in each mouse macrophage cluster
Supplementary Figure S14 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S14
Supplementary Figure S11 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S11
Supplementary Figure legends from PTEN Loss Shapes Macrophage Dynamics in High-Grade Serous Ovarian Carcinoma
Authors: Spear Sarah , Le Saux Olivia , Mirza Hasan B. , Iyer Nayana , Tyson Katie , Grundland Freile Fabio , Walton Josephine B. , Woodman Chloé , Jarvis Sheba , Ennis Darren P. , Aguirre Hernandez Carmen , Xu Yuewei , Spiliopoulou Pavlina , Brenton James D. , Costa-Pereira Ana P. , Cook David P. , Vanderhyden Barbara C. , Keun Hector C. , Triantafyllou Evangelos , Arnold James N. , McNeish Iain A.
Published: November 2024

Legends to supplementary figures
Supplementary Figure S1 from Galectin-9 Mediates the Functions of Microglia in the Hypoxic Brain Tumor Microenvironment
Authors: Lee Chanju , Yu Dahee , Kim Hyung-Seok , Kim Ki Sun , Chang Chi Young , Yoon Hee Jung , Won Su Bin , Kim Dae Yeon , Goh Eun Ah , Lee Yong Sun , Park Jong-Bae , Kim Sang Soo , Park Eun Jung
Published: November 2024

Supplementary Fig. S1
Supplementary Table S5 from YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer
Authors: Song Hongtao , Lu Tong , Han Donghui , Zhang Jiayu , Gan Lunbiao , Xu Chao , Liu Shaojie , Li Peng , Zhang Keying , Hu Zhihao , Li Hongji , Li Yu , Zhao Xiaolong , Zhang Jingliang , Xing Nianzeng , Shi Changhong , Wen Weihong , Yang Fa , Qin Weijun
Published: November 2024

Supplementary Table 5: Human primers for qRT-PCR analysis
Supplementary Figures and Legends from Low–Molecular Weight Cyclin E Confers a Vulnerability to PKMYT1 Inhibition in Triple-Negative Breast Cancer
Authors: Li Mi , Lulla Amriti R. , Wang Yan , Tsavaschidis Spyros , Wang Fuchenchu , Karakas Cansu , Nguyen Tuyen D.T. , Bui Tuyen N. , Pina Marc A. , Chen Mei-Kuang , Mastoraki Sofia , Multani Asha S. , Fowlkes Natalie W. , Sahin Aysegul , Marshall C. Gary , Hunt Kelly K. , Keyomarsi Khandan
Published: November 2024

This file includes all the 8 supplementary figures and their corresponding figure legends referred to in the main text.
Supplementary Table S3 from YAP1 Inhibition Induces Phenotype Switching of Cancer-Associated Fibroblasts to Tumor Suppressive in Prostate Cancer
Authors: Song Hongtao , Lu Tong , Han Donghui , Zhang Jiayu , Gan Lunbiao , Xu Chao , Liu Shaojie , Li Peng , Zhang Keying , Hu Zhihao , Li Hongji , Li Yu , Zhao Xiaolong , Zhang Jingliang , Xing Nianzeng , Shi Changhong , Wen Weihong , Yang Fa , Qin Weijun
Published: November 2024

Supplementary Table 3: Antibodies for Flow Cytometry
Table S1 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer
Authors: Koo Junghui , Seong Chang-Soo , Parker Rebecca E. , Herrera Amy , Dwivedi Bhakti , Arthur Robert A. , Dinasarapu Ashok Reddy , Johnston Henry Richard , Claussen Henry , Tucker-Burden Carol , Ramalingam Suresh S. , Fu Haian , Zhou Wei , Marcus Adam I. , Gilbert-Ross Melissa
Published: November 2024

List of upregulated transcripts in KL vs. KP invasive spheroids with respect to K>C.
Figure S5 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer
Authors: Koo Junghui , Seong Chang-Soo , Parker Rebecca E. , Herrera Amy , Dwivedi Bhakti , Arthur Robert A. , Dinasarapu Ashok Reddy , Johnston Henry Richard , Claussen Henry , Tucker-Burden Carol , Ramalingam Suresh S. , Fu Haian , Zhou Wei , Marcus Adam I. , Gilbert-Ross Melissa
Published: November 2024

Figure S5
Figure S3 from Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer
Authors: Koo Junghui , Seong Chang-Soo , Parker Rebecca E. , Herrera Amy , Dwivedi Bhakti , Arthur Robert A. , Dinasarapu Ashok Reddy , Johnston Henry Richard , Claussen Henry , Tucker-Burden Carol , Ramalingam Suresh S. , Fu Haian , Zhou Wei , Marcus Adam I. , Gilbert-Ross Melissa
Published: November 2024

Figure S3
Supplementary Figure Legends from Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Authors: Pan Yani , Zhou Yue , Shen Yonghua , Xu Lei , Liu Hongwen , Zhang Nannan , Huang Tianlu , Meng Kui , Liu Yu , Wang Lishan , Bai Ge , Chen Qi , Zhu Yun , Zou Xiaoping , Wang Siliang , Wang Zhangding , Wang Lei
Published: November 2024

Supplementary Figure Legends
Supplementary Figure 9 from Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Authors: Pan Yani , Zhou Yue , Shen Yonghua , Xu Lei , Liu Hongwen , Zhang Nannan , Huang Tianlu , Meng Kui , Liu Yu , Wang Lishan , Bai Ge , Chen Qi , Zhu Yun , Zou Xiaoping , Wang Siliang , Wang Zhangding , Wang Lei
Published: November 2024

Hypoxia triggers PYGB to regulate ER stress to alter malignancy of CCA in vitro.
Supplementary Figure 8 from Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Authors: Pan Yani , Zhou Yue , Shen Yonghua , Xu Lei , Liu Hongwen , Zhang Nannan , Huang Tianlu , Meng Kui , Liu Yu , Wang Lishan , Bai Ge , Chen Qi , Zhu Yun , Zou Xiaoping , Wang Siliang , Wang Zhangding , Wang Lei
Published: November 2024

PYGB regulates ER stress and apoptosis in CCA.
Tables S1 and S2 from The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling
Authors: Heath John , Mirabelli Caitlynn , Annis Matthew G. , Sabourin Valerie , Hebert Steven , Findlay Steven , Kim HaEun , Witcher Michael , Kleinman Claudia L. , Siegel Peter M. , Orthwein Alexandre , Ursini-Siegel Josie
Published: November 2024

Supplementary Table 1: Oligonucleotides employed in this study. Supplementary Table 2: Antibodies used in this study.
Supplementary Figure 7 from Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Authors: Pan Yani , Zhou Yue , Shen Yonghua , Xu Lei , Liu Hongwen , Zhang Nannan , Huang Tianlu , Meng Kui , Liu Yu , Wang Lishan , Bai Ge , Chen Qi , Zhu Yun , Zou Xiaoping , Wang Siliang , Wang Zhangding , Wang Lei
Published: November 2024

PYGB regulates cell cycle progression of CCA in vitro.
Supplementary Figure 6 from Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Authors: Pan Yani , Zhou Yue , Shen Yonghua , Xu Lei , Liu Hongwen , Zhang Nannan , Huang Tianlu , Meng Kui , Liu Yu , Wang Lishan , Bai Ge , Chen Qi , Zhu Yun , Zou Xiaoping , Wang Siliang , Wang Zhangding , Wang Lei
Published: November 2024

PYGB promotes malignant progression of murine CCA.
Figure S1 from The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling
Authors: Heath John , Mirabelli Caitlynn , Annis Matthew G. , Sabourin Valerie , Hebert Steven , Findlay Steven , Kim HaEun , Witcher Michael , Kleinman Claudia L. , Siegel Peter M. , Orthwein Alexandre , Ursini-Siegel Josie
Published: November 2024

Supplemental Figure 1 with legend
Supplementary Figure 13 from Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Authors: Pan Yani , Zhou Yue , Shen Yonghua , Xu Lei , Liu Hongwen , Zhang Nannan , Huang Tianlu , Meng Kui , Liu Yu , Wang Lishan , Bai Ge , Chen Qi , Zhu Yun , Zou Xiaoping , Wang Siliang , Wang Zhangding , Wang Lei
Published: November 2024

Carvedilol suppressed the malignancy of CCA in vivo.
Supplementary Figure 11 from Hypoxia Stimulates PYGB Enzymatic Activity to Promote Glycogen Metabolism and Cholangiocarcinoma Progression
Authors: Pan Yani , Zhou Yue , Shen Yonghua , Xu Lei , Liu Hongwen , Zhang Nannan , Huang Tianlu , Meng Kui , Liu Yu , Wang Lishan , Bai Ge , Chen Qi , Zhu Yun , Zou Xiaoping , Wang Siliang , Wang Zhangding , Wang Lei
Published: November 2024

Screening of Carvedilol as a CCA therapeutic drug.
original gels from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma
Authors: Zhang Jiayi , Ni Zihui , Zhang Yu , Guo Yan , Zhai Rundong , Wang Mengqi , Gong Zizhen , Wang Mengyao , Zeng Fanrui , Gu Ziyue , Chen Qianming , Liu Laikui , Wang Zhiyong , Zhu Weiwen
Published: November 2024

original gels for western blot
Supplementary Material and Method from DAZAP1 Phase Separation Regulates Mitochondrial Metabolism to Facilitate Invasion and Metastasis of Oral Squamous Cell Carcinoma
Authors: Zhang Jiayi , Ni Zihui , Zhang Yu , Guo Yan , Zhai Rundong , Wang Mengqi , Gong Zizhen , Wang Mengyao , Zeng Fanrui , Gu Ziyue , Chen Qianming , Liu Laikui , Wang Zhiyong , Zhu Weiwen
Published: November 2024

Supplementary Materials and Methods