bluuebunny/crossref_metadata_2025 huggingface dataset:
Ectopic pituitary adenoma: a rare and unexpected diagnosis, clinical presentation and review of the literature
Authors: Singh V. P. , Arora Pankaj , Rubini Alessia , Bansal Chetan , Varma Arvind
Published: October 2020

Nasal obstruction can be caused by many causes. Most common cause of nasal obstruction is deviated nasal septum followed by nasal masses. Nasal masses can be polyps, tumors or foreign bodies. We are presenting a case of ectopic pituitary tumor as a as cause of nasal obstruction along. Ectopioc pituitary tumors are rare tumors and can present in nasal cavity causing nasal symptoms. They can cause unilateral or even bilateral nasal obstruction depending on their spread in nasopharynx and nose and should be kept in mind while treating a case of nasal masses.
High-grade non-salivary non-intestinal adenocarcinoma of the nasal cavity-a less known entity
Authors: Pradhan Prita , Panigrahi Ranjita , Misra Pranati , Senapati Urmila , Samantaray Kabikanta
Published: October 2020

Sinonasal region, with its anatomical complexity, is commonly associated with a number of tumors. Salivary gland tumors are frequent but adenocarcinomas are uncommon.Here presented an uncommon case of high-grade adenocarcinoma non-salivary non-intestinal type.
The efficacy and safety of Short course therapy with Cefixime in URTI in Indian Scenario
Authors: Dhoot Dhiraj , Pakhale Ketan , K Tandon G , Bansal Tanma , Jain Vineet
Published: October 2020

Upper respiratory tract infections (URTI) are one of the commonest cause for a patient’s visit to outpatient department (OPD). Short course therapies with penicillin and cephalosporin class of antibiotics are commonly prescribed in URTI cases. This study was a retrospective, multicentre, observational cohort analysis, planned to evaluate the effectiveness and safety of Cefixime 400 mg per day in patients of URTI, using WURSS 21 score. We analysed the data of 200 patients who were prescribed Cefixime for URTI. Most of the patients (55%) were male. The baseline mean WURSS score of 41.09 ± 33.45 decreased to 25.74 ± 22.29 [(-37.3%), p value<0.05] at visit 2; moreover, it further decreased to 5.75 ± 6.75 [(-86.0%), p value<0.05] at visit 3. Similar trend was noted for WURSS symptom score and WURSS Quality of life score. At baseline, mean WURSS Symptom score was 25.34 ± 15.97 which was reduced to 16.32 ± 11.50 at visit 2 and 4.15 ± 4.50 at visit 3. Similarly, mean WURSS Quality of life score at baseline was 15.74 ± 18.41 which was reduced to 9.42 ± 11.66 and 1.59 ± 2.75 at visit 2 and visit 3 respectively. None of the patients reported adverse effects. The findings of the present survey confirm the effectiveness and safety of short course of Cefixime therapy in URTI.
Microbiological profile and their antibiotic sensitivity pattern in patients of chronic suppurative otitis media at eastern tertiary care center of Nepal
Authors: Prasad Sah Bajarang , Thapa Chettri Shyam , Raj Bhattarai Narayan , Prasad Shah Shankar , Paudel Deepak
Published: October 2020

Chronic suppurative otitis media (CSOM) is one of the most common and an important global public health problem leading to hearing impairment and is particularly prevalent in developing countries. Even in this era of powerful antibiotics, due to increased irrational use of wide spectrum antibiotics, the resistance in the bacterial isolates is common. The objective of the study was to determine the aerobic bacterial etiology of patients with CSOM and the antimicrobial susceptibility of the bacteria isolated.

A descriptive cross sectional study was carried out in 112 patients suffering from chronic discharging ear. Pus samples were cultured aerobically. Antibiotic sensitivity testing was performed with standard antibiotic discs using modified Kirby-Bauer disk diffusion method.

Out of 112 patients, 70 (62.5%) were females. Among 112 swab cultures, 98 (87.5%) were positive for the growth of organism and 14 (12.5%) were sterile cultures. Among them Staphylococcus aureus (42.24%), Pseudomonas aeruginosa (28.44%), Klebsiella pneumoniae (10.34%), Acinetobacter anitratus (6.9%), Proteus mirabilis (5.17%) and E. coli (4.31%) were the common microbial isolates. Among the antibiotics commonly available as topical eardrops, Ofloxacin (91.83%)) had the highest susceptibility rate, followed by Ciprofloxacin (81.63%), Tobramycin (73.46%) and Gentamicin (63.26%).

Staphylococcus aureus was the most common organism isolated followed by Pseudomonas aeruginosa. Ofloxacin had the highest susceptibility rate against the isolated organisms.
Comparative Efficacy of intra-tympanic methylprednisolone injections in different concentrations on subjective cochlear tinnitus
Authors: Gupta Manish , Gupta Monica , Kumar Satish
Published: October 2020

Subjective tinnitus is an awareness of a phantom sound which is audible solely to the individual. Intra-tympanic steroid injections especially dexamethasone 8mg/ml have been used with variable success in relieving it; however this desired concentration is unavailable in India. The aim of this study was to assess the comparative efficacy of intra-tympanic methylprednisolone injections in different concentrations in subjective cochlear tinnitus.

Ninety patients with complaint of abnormal ringing in uni/bilateral ear, with/without hearing loss were enrolled from our outpatient set-up. After written informed consent, the participants received a tinnitus loudness and frequency matching test. They were randomly assigned into three different subgroups (each with 30 patients) by a single-blind method.0.5ml of 40mg/ml concentration methylprednisolone solution was injected intratympanically in study set one (Group A), 125mg/ml in second set (Group B) and 250mg/ml in the third set (Group C). The groups were compared in terms of subjective tinnitus intensity and loudness matching after the intervention.

On subjective analysis of tinnitus intensity 1 patient of Group A and 2 each of groups B and C demonstrated improvement. On loudness matching test for tinnitus, no patient in Group A was cured, though 3 each in groups B and C were cured.

In the present study, no significant change was observed in the three treatment groups in subjective analysis of tinnitus intensity based on questionnaire. Similarly a non-significant response was obtained in loudness matching test for tinnitus. The intra-tympanic methylprednisolone injection gave suboptimal and inconsistent results at varying concentrations. Further prospective studies to evaluate the effect of intratympanic methylprednisolone on tinnitus are warranted in carefully selected group of patients.
A study of single sided mucoperichondrial resection versus conventional technique in submucosal resection
Authors: B. S Vidyashree , K Pai Vishwas , S. G Mahesh , P P Devan , Paulson Happy
Published: October 2020

Nasal septal deviation is a condition which is frequently encountered in the general population. Surgical correction of this problem has been the mainstay of treatment for over a century.

This study is to compare SMR with Single sided mucoperichondral resection. This new technique in Septal Surgery is found without complication whereas complications were noted in SMR.

The study to compare the Single sided mucoperichondrial resection versus conventional SMR was carried out in the Department of Otorhinolaryngology at AJ Institute of Medical Sciences and Research Centre, Mangalore, Karnataka during the period from 1 October 2018 to 31 September 2019.

A total of 20 cases with symptomatic DNS were included in the study, after randomization 10 cases underwent conventional SMR and 10 cases Single sided mucoperichondrial resection.

Among 10 patients who underwent conventional SMR, Septal hematoma and septal perforation were the most common complications. None of the patients who underwent Single sided mucoperichondrial resection had any complications.

In conventional SMR, retention of both mucoperichondrial flaps results in many recognized post op complications. In Single sided mucoperichondrial resection, no complications were seen in comparison.
Water-Soluble Substances of Arglabin
Authors: Adekenov S.M. , Zhabayeva А.N. , Baisarov G.М.
Published: October 2020

The article discusses the results of a study of the water solubility of natural sesquiterpene lactone arglabin, in particular, its ability to complex formation with complexing agents polyvinylpyrrolidone, the disodium salt of glycyrrhizic acid, magnesium carbonate. Mechanocomposites with polyvinylpyrrolidone and disodium salt of glycyrrhizic acid, which have increased water solubility, were obtained by the method of mechanochemical treatment of arglabin native. At the same time, the best result of dissolution in water is achieved by a two-hour treatment with polyvinylpyrrolidone and with disodium salt of glycyrrhizic acid. The water solubility of complex compounds of arglabin with polyvinylpyrrolidone increases by 4.61 times, and with disodium salt of glycyrrhizic acid by 4.42 times.
Antibacterial Activity of Synthesized Derivatives of Purpurin
Containing Cyсlopropane and Cyclobutane Fragment
Authors: Kharlamova Т.V. , Gabdrakipov A.V. , Seidakhmetova P.B. , Praliyev K.D.
Published: October 2020

The present study is a continuation of the scientific research works for the synthesis of anthraquinonе-containing derivatives with cyclic ring systems by the interaction of 1,2,4-trihydroxyanthraquinone (purpurin) with cyclopropanecarboxylic acid chloride and cyclobutanecarboxylic acid chloride by using the ultrasonic treatment. Esters of purpurin, studied for antibacterial activity in museum test strains of microorganisms (Staphylococcus aureus ATCC 6538-P, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Pseudomonas aeruginosa АТСС 27853, Сandida albicans АТСС 10231) in vitro with the determination of the minimum inhibitory concentration (MIC) value. The study revealed that the cyclopropane substituent exhibits moderate antibacterial activity against Bacillus subtilis ATCC 6633. While with the cyclobutane moiety it had a weak effect with respect to Pseudomonas aeruginosa ATCC strain. It has been found that the compounds with the cyclopropane and cyclobutane fragment have possessed antimicrobial activity in relation to strains of microorganisms Staphylococcus aureus АТСС 6538 for which the MIC value was 62.5 μg/ml.
Pilot Production of Spirulina Biomass and Obtaining
of Novel Biodegradable Surfactants
Authors: Umerzakova M.B. , Donenov B.K. , Kainarbaeva Z.N. , Kartay A.M. , Sarieva R.B.
Published: October 2020

The research results describe the pilot production of microalgae biomass – Spirulina, especially in wintertime, using the geothermal energy of water to save the costs for heating of the pool photobioreactor and biomass drying box. For carrying out of the process a simplified nutrient medium consisting of geothermal water and salts: sodium bicarbonate, potassium nitrate, diammonium phosphate, and urea was developed. The conditions for the Spirulina biomass cultivation in wintertime were optimized. The technical and economic feasibility and conditions for large-scale production of Spirulina in Kazakhstan for commercial purposes are justified. It has been shown that the Spirulina biomass may serve as a feedstock for the production of biodegradable surfactants.
Effect of Cobalt Oxide Content on the Activity of NiO-Co2O3/γ-Al2O3
Catalyst in the Reaction of Dry Reforming of Methane to Synthesis Gas
Authors: Myltykbayeva L.K. , Ergazieva G.E. , Telbayeva M.M. , Ismagilov Z.R. , Dossumov K. , Popova А.N. , Sozynov S.А. , Turgumbayeva R.H. , Hitsova L.M.
Published: October 2020

The effect of cobalt oxide content on the activity of NiO-Co2O3/γ-Al2O3 catalyst was investigated in process of dry reforming of methane (DRM) to synthesis gas. It was found that among the studied catalysts the highest activity is shown by the NiO-Co2O3/ γ-Al2O3, where methane conversion is 89%. It was determined by the scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD) there are oxides of Ni and Co in the form of nanosized particles on active NiO-Co2O3/γ-Al2O3 catalyst and Co-Ni alloys, formed after the reaction of DRM, the size of 17‒23 nm. Thermogravimetric Analysis (TGA)/ Differential Thermal Analysis (DTA)/ Differential Scanning Calorimetry (DSC) of catalyst showed that the highest weight loss (2.7%) is observed at a degree from 30 to 260 °C after DRM. After heating above 300 °C there is a slight increase in weight, accompanied by an exothermic effect on the DSC curve due to the gas adsorption used to purge the unit. The data indicate the absence of coke formation on NiO-Co2O3/γ-Al2O3 surface. According to TPR-H2 there are peaks at relatively low temperatures of Т1mах = 205 °C and Т2mах = 497 °C on thermally programmed reduction (TPR) TPR-Н2 spectrum of NiO-Со2О3/γ-Al2O3, which are associated with the formation of easily reducible cobalt and nickel oxides, indicating the presence of active and mobile oxygen in the catalyst. These results confirm that the activity of NiO-Co2O3/γ-Al2O3 is due to the formation of nanophases, the presence of active oxygen, and the absence of coke on the catalyst surface.
Mathematical Model to Predict the Affinity Between Aggregate/Bitumen
Authors: Caputo P. , Ranieri G.A. , Miriello D. , Bloise A. , Abe A.A. , Teltayev B. , Oliviero Rossi C.
Published: October 2020

The stones used for the construction of road surfaces have a complex mineralogical and hence chemical composition. They are made up of several types of minerals put together. This generates a significant difference in adhesion with the bituminous binder. The aim of this study is to create a mathematical model able to predict the adhesion between bitumen and stone on the basis of contact angle measurements made on different pure minerals. The mathematical model used was developed keeping in mind the exponential bond that the minerals have with the corresponding bond angle. This model also confirmed the established fact that the lower the value of Δ, the better the adhesion between the bitumen and the aggregate.
Electrochemical Separation of Molybdenum and Tungsten Using Aqueous-Organic Electrolytes
Authors: Kudreeva L.K. , Kurbatov A.P. , Kamysbayev D.Kh. , Kalyyeva A.R. , Zhumasheva N.Zh. , Abilev M.B. , Serikbayev B.A. , Dauletbay A.
Published: October 2020

Molybdenum is one of the valuable metals for the industry; its special properties make it extremely urgent to study the process of separation of molybdenum from other impurities. The article considers the optimization of electrochemical separation of molybdenum from Mo-W system. The electrochemical dissolution of molybdenum and tungsten in solutions of LiCl and NH4NO3 in dimethylsulfoxide was studied using polarization curves and calculation of the efficiency of anodic dissolution of molybdenum in the presence of tungsten. The electrolyte with a composition of 0.5 M LiCl; 5.2 M dimethylsulfoxide; 32.2 M water was selected as an effective solution for the electrochemical separation of molybdenum in the potential range of 1.0‒2.2 V. Results obtained in this study can be used for the development of selective separation method in the molybdenum production.
PRODUTIVIDADE DE CINCO CULTIVARES DE ALHO NOBRE SUBMETIDOS À DIFERENTES PERÍODOS DE VERNALIZAÇÃO
Authors: Tavares de Ávila Vinícius
Published: October 2020

O Brasil, apesar de produtor comercial de alho, ainda não é capaz de suprir toda a demanda do mercado consumidor interno, entre os problemas enfrentados podemos destacar a infecção viral, o superbrotamento e a vernalização. Tecnologias como a produção por bulbilhos-semente livres de vírus, mais produtivos que os infectados e técnicas agrícolas que reduzam a incidência do superbrotamento e o uso mais eficiente do processo de vernalização. O objetivo deste trabalho foi avaliar o desempenho de cinco cultivares de alho, submetidas a diferentes períodos de vernalização em câmara fria. O experimento foi conduzido em blocos casualizados ao acaso com as cultivares Ito, Caçador, Jonas, Chonan e Quitéria. Foram realizadas avaliações da produção total de bulbos, porcentagem de superbrotamento, massa média dos bulbos e produção comercial de bulbos. Foi observada redução da porcentagem de superbrotamento com o aumento do período de vernalização para as cultivares Quitéria, Jonas e Ito. As cultivares Chonan, Caçador e Quitéria apresentaram os melhores valores para massa média de bulbos nos tratamentos de 50 e 60 dias de vernalização. A produção comercial de bulbos foi afetada negativamente com o aumento do período de vernalização. As cultivares Chonan, Jonas e Quitéria apresentaram suas maiores produtividades com 50 dias de vernalização apresentando tendência de redução da produtividade com o aumento do período de vernalização. A cultivar Caçador não apresentou diferença significativa entre os tratamentos e a cultivar Ito não apresentou tendência de aumento ou redução da produtividade entre os diferentes tratamentos.
Silicon in the morphometry and germination of corn seeds for silage
Authors: Brennecke Kathery , Sarro Letícia , Dian Paulo Henrique Moura , Ferrari Maria Helena , Bertipaglia Liandra Maria Abaker , Amancio Weberson Donizete de Castro
Published: October 2020

As a forage, the objective of this study was to evaluate corn plant, seed development and seed germination in response to silicon application at different doses pathway leaf. The experimental design was randomized blocks with four treatments of different doses of silicon, equivalent to 0.0, 100.0, 200.0 and 300.0kg ha-1 of calcium silicate, at 22%, and four replications, applied pathway leaf. It was observed that the applied silicon did not influence any of the plant morphometric variables, however it altered the ear characteristics regarding weight and diameter, at which the best response was observed in the application equivalent to 100kg silicate-1 ha-1. The applied silicon doses showed no significant differences in morphological characteristics such as plant height, first ear height, stem diameter, number, and leaf angles. Significant differences were found in the weight of one thousand grains, and by increasing the silicon dose, there was an increase in the weight of one thousand grains and in the germination; in 7 days, it was found a decrease in germination percentage as well as in the percentage of normal seedlings when increasing the calcium silicate doses. It was concluded that the application of calcium silicate via leaf increased the stem diameter, the ear of corn and the weight of one thousand seeds and decreased the germination percentage in seven days and the appearance of normal seedling.
Folha de Rosto
Authors: Agrogeoambiental Revista
Published: October 2020

Folha de Rosto
Expediente
Authors: Agrogeoambiental Revista
Published: October 2020

Expediente
Summary
Authors: Agrogeoambiental Revista
Published: October 2020

Summary
Intracoronary Versus Intravenous Administration of Eptifibatide During Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes
Authors: Dehghani Dashtabi Soroush , Falsoleiman Homa , Dastani Mostafa , Mouhebati Mohsen , Ahmadi Mostafa , Khameneh Bagheri Ramin , Dehghan Amin , Dehghani Dashtabi Mashallah
Published: October 2020

Platelet activation and aggregation play a major role in thrombosis formation of coronary arteries in patients with Acute Coronary Syndrome (ACS) and is responsible for most ischemic complications during PCI. There is little information on the benefits and side effects of intracoronary and intravenous injection of Eptifibatide, a potent antiplatelet agent; therefore, this study was performed with the aim to compare coronary blood flow velocity by measurement of TIMI frame count. In intravenous versus intracoronary bolus administration of Eptifibatide during PCI in ACS patients. This non-randomized clinical trial study was performed on 103 patients with acute coronary syndromes who referred to the cardiac emergency ward of Ghaem hospital, Mashhad University of Medical Sciences, and were candidates for urgent coronary angiography and PCI. Forty-eight cases received intracoronary bolus Eptifibatide and 55 intravenous Eptifibatide. TIMI Frame Count and Corrected TIMI Frame Count were used to comparing the effect of these two methods on coronary blood flow velocity. Data were analyzed by SPSS software (version 22). To compare the quantitative variables in the two groups, according to the distribution of variables, the t-test was used if it was normal or the Mann-Whitney test was used if it was not normal. A Chi-square test was also used to compare qualitative variables into two groups. P<0.05 was considered statistically significant. Mean of age, gender, and cardiovascular risk factors were similar in the two groups. There was no significant difference in terms of serum Creatine Kinase MB (CKMB) level, Left Ventricular Ejection Fraction (LVEF), coronary artery lesion length, coronary artery diameter, coronary thrombosis, and coronary artery thrombectomy in two groups. Based on Student's t-test, there was no significant difference between mean TIMI Frame Count in different coronary arteries in the intracoronary and intravenous injection groups (In LAD, P=0.518; For LCX, P=0.576; and in RCA, P=0.964). The complications were observed in 11 patients (22.9%) of the intracoronary injection group and 9 (16.4%) of the intravenous injection group; the difference was not significant (P=0.402). The effects and complications of Eptifibatide were not significantly different in Intracoronary and intravenous administration in ACS patients during PCI and at the time of patients' hospitalization.
Resistance to Antimicrobial Agents, Chemical Disinfectants and Distribution of Effectors Proteins of Type Three Secretion System in Pseudomonas aeruginosa Isolated From Burn and Hospital Environments in South East of Iran
Authors: Rahmati Mehdi , Mansouri Shahla , Sharifi Hossein
Published: October 2020

Pseudomonas aeruginosa (P. aeruginosa) is a common bacteria associated with burn infections and resistance to a wide range of disinfectants and antimicrobial agents which is able to produce different virulence factors. In this study, the susceptibility of P. aeruginosa isolates from the burn (burn=57) and hospital environment (HE=19) to antimicrobial agents and chemical disinfectants was determined by disc and well diffusion agar method, respectively. The results showed 100% sensitivity to polymyxin B, while sensitivity to other agents was low and ranged from 40.8% for imipenem and amikacin to 6.6% for ceftizoxime. Among the disinfectant used, the mean diameter of inhibition zones (DIZ) was higher for Deconex, while nitrofurazone had the lowest DIZ. In most cases, the HE isolates were significantly more susceptible to disinfectants and antimicrobial agents compared to burn isolates (P≤0.01). The genes for the exoenzyme T, Y, U, and S were detected in 100%, 89.8%, 43.4%, and 48.7% of the isolates, respectively. The prevalence of exo U and exoY was significantly higher in the burn isolates compared to HE isolates (P=0.001). The results of this study indicate a significantly higher level of resistance against the majority of the antimicrobial agents in the burn isolates compared to HE isolates, which was significantly higher than the environmental isolates. The prevalence of T3SS effectors proteins and their pattern were also different in the burn, and the HE isolates, indicating a divergence in pathogenicity of the burn isolates from those of the environmental isolates.
Textos multimodais na sala de aula: exercícios
Authors: Ribeiro Ana Elisa
Published: October 2020

Neste artigo, tratamos da abordagem multimodal dos textos e de suas relações com a Base Nacional Comum Curricular. Passamos então a apresentar duas possibilidades de exercícios de leitura para a sala de aula, buscando uma aproximação com a BNCC. As peças textuais empregadas são de ampla circulação social e podem abrir espaço para muitas análises e mesmo para a produção de textos, em algumas etapas do ensino básico. Finalmente, consideramos a abordagem multimodal produtiva para a formação de leitores/as e produtores/as de textos, dentro do que vem sendo pensado na contemporaneidade.
Ege Üniversitesi hastanesi veri tabanında çoklu primer kanserlerin analizi
Authors: HAYDAROĞLU Ayfer , SERT Fatma , CANER Ayşe
Published: October 2020

Amaç: Ege Üniversitesi Hastanesi (EÜH) kanser veri tabanında birden çok sayıda kanserleri olanÇoklu Primer Kanser (ÇPK)’li olguların sayıca artışı dikkat çekici bulunmuş, bu artışın istatistik olarakanalizi planlanmıştır.Gereç ve Yöntem: EÜH’de EÜKAM tarafından CANREG-4 özel bilgisayar programına kayıt edilenkanser verileri WHO ve Surveillance, Epidemiology, and End Results (SEER) sistemleri temelindegruplanarak analizler yapılmıştır. İstatistik analizlerde Ki-kare, General Linear Model, Kaplan Meiersağkalım analizleri uygulanmıştır. Kaplan Meier Sağkalım analizinde Log Rank (Mantel-Cox), Breslow(Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmış, istatistik analizlerde p <0,05istatistiksel olarak anlamlı kabul edilmiştir.Bulgular: EÜH veri tabanında 1992-2018 yılları arasında kaydedilmiş 124.321 kanser olgusunun6.311’inde birden çok kanser (%5,1) saptanmıştır. ÇPK görülüşü erkeklerde daha belirgindir(p<0,0001). ÇPK’de yıllara göre bir artış saptanmıştır (p<0,0001). Her iki cinste en sık görülenGastrointestinal sistem (GİS) kanserlerinde ÇPK genellikle yine GİS ile ilgili olmakta, bunu ürogenitalsistem (ÜGS) kanserleri izlemektedir. Akciğer kanseri ile beraber görülen ÇPK’lerin başında diğersolunum sistemi kanserleri gelmekte, bunu mesane kanserleri izlemektedir. Meme kanserini izleyenÇPK’ler endometrium ve over kanseridir. ÇPK’lerde sağkalım tek primer kanserlilere göre daha kötüve çoklu ÇPK sayısı arttıkça sağkalımlar daha kötü olmaktadır (p<0,001). Olguların %18,2’si senkron,%81,8’i metakron olup sağkalım açısından istatistiksel olarak aradaki fark anlamlı değildir (p=0,506).Sonuç: EÜH Hastanesi veri tabanında %5,1 ÇPK saptanmış olup yıllara göre bir artış eğilimi vardır.Senkron veya metakron gelişen ÇPK’lar da sağkalım farkı bulunmamıştır. Çoklu primer kanserlerdesağkalım tekli kanserlere göre daha kötü olup ÇPK sayısı arttıkça GSK’lar daha kötü olmaktadır.
Ege Üniversitesi Hastanesi veri tabanında kayıtlı erişkin Hodgkin lenfoma olgularının epidemiyolojik ve genel sağ kalım özelliklerinin retrospektif olarak değerlendirilmesi
Authors: DEMİR Derya , HEKİMGİL Mine , DEMİR Emre , BÜLBÜL Hale , ULUSOY Yusuf , AKAD SOYER Nur , ANACAK Yavuz , SAYDAM Güray , ŞAHİN Fahri , ÖZSAN Nazan
Published: October 2020

Amaç: Hodgkin lenfoma (HL) sıklığı ve mortalite oranları tüm dünyada değişkenlik göstermektedir. Bu
çalışmada, HL olgularının epidemiyolojik ve genel sağ kalım analizlerinin, global sonuçlarla
karşılaştırılarak değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezi veri tabanına
kayıtlı, 1992-2017 yıllarında HL tanısı alan 972 erişkin olgu retrospektif olarak değerlendirilmiş,
CANREG-4 ile kaydedilen veriler SPSS’e aktarılmıştır.
Bulgular: Olguların %59,9’u erkek olup, ortalama tanı yaşı 41,8 ve medyan tanı yaşı 39 idi. Olguların
%94,4’ü klasik Hodgkin lenfoma (KHL) tanısı aldı. Alt tiplerine baktığımızda %42,1 nodüler sklerozan
(NS)-KHL, %31,0 mikst sellüler (MS)-KHL, %5,2 lenfositten zengin (LZ)-KHL, %2,9 lenfositten fakir
(LF)-KHL olarak değerlendirildi. Erkeklerde kadınlara göre anlamlı yüksekti. Noduler lenfosit
predominant HL olgularının tamamı EBV negatif iken; KHL olgularının %52,7’si pozitifti (p<0,0001).
Ayrıca %59 lokalize, %16,4 bölgesel, %24,7 yaygın hastalık oluşturmaktaydı. Sağ kalım analizleri
bilinen 971 olgunun sağkalımı 1 yıllık %92, 5 yılllık %81, 10 yıllık %70, 15 yıllık %62, 25 yıllık %43 idi.
Kemik iliği lokalizasyonundan tanı alan olguların sağ kalımının kısa olduğu saptandı (p<0,0001).
Sonuç: HL, en sık görülen ikinci lenfoma tipi olup, erkeklerde kadınlara göre daha sık karşımıza
çıkmaktadır. NSKHL en sık görülen alt tip olmakla birlikte, gelişmiş ülkelere göre biraz daha az
görüldüğü, MSKHL ve LFKHL alt tiplerinin ise daha ön plana çıktığı dikkatimizi çekmektedir. Ayrıca
olgularımızda EBV görülme oranları, gelişmiş ülkelere kıyaslandığında fazla olup, Asya ve Latin
Amerika’ya göre daha düşüktür. Erkeklerde, kemik iliği tutulumu olanlarda ve yaygın hastalık
oluşturanlarda sağ kalım daha kısa bulunmuştur. Prognostik açıdan, cinsiyet ve hastalık evresi bizim
çalışmamızda da öne çıkan önemli parametreler arasında saptanmıştır.
Ege Üniversitesi Hastanesinde görülen melanom dışı deri kanserlerinin epidemiyolojik ve demografik özellikleri
Authors: ACAR Ayda , YAMAN Banu , YANMAZ Ayris , YOLDAŞ Ayşe Hande , KARAARSLAN Işıl , AKALIN Taner , ÖZDEMİR Fezal , GERÇEKER TÜRK Bengü , CANER Ayşe , KANDİLOĞLU Gülşen , HAYDAROĞLU Ayfer , CEYLAN Can
Published: October 2020

Amaç: Bu çalışmada Ege Üniversitesi Hastanesi veri tabanındaki 1992-2017 yılları arası melanom dışı malign deri kanseri tanısı alan hastaların epidemiyolojik ve demografik özelliklerinin değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezinin özel eğitimli ve sertifikalı kanser kayıt elemanları tarafından CANREG 4 programı ile kaydedilen 1992-2017 yılları arasında Ege Üniversitesinde kayıtlı 8395 melanom dışı malign deri kanseri tanılı hastanın; tanı yaşı, cinsiyeti, tümörün histopatolojik tanısı, tümör yerleşim yeri, hastalık evresi ve uygulanan tedavi yöntemleri değerlendirilmiştir. Kategorik değişkenler arası ilişki varlığı Ki-Kare yöntemiyle değerlendirilirken, gruplar arası nümerik değişkenler Kruskal Wallis ve Dunn Testi ile karşılaştırıldı. Tüm Hipotez testleri 0,05 önem seviyesinde uygulandı.
Bulgular: Ege Üniversitesi Kanser Araştırma Merkezinde 1992 ile 2017 yılları arasında kayıtlı melanom dışı deri kanseri olan 8395 hastanın 8386’sı dahil edildi. Hastaların %55,9’unda bazal hücreli karsinom, %30,3’ünde skuamoz hücreli karsinom, %3,6’sında malign kutanöz yumuşak doku tümörü, %3,4’ünde bazoskuamoz karsinom, %2,7’sinde kutanöz lenfoma, %1,4’ünde malign deri eki tümörü, %0,4’ünde Merkel hücreli karsinom, %2,3’ünde sınıflandırılamayan tümör mevcuttu. Hastaların %57,3’ü erkek, %42,7’si kadındı. Yaş ortalaması 63,3±14,3 idi.
Sonuçlar: Olguların çoğunu epitelyal karsinomlar oluşturmakta idi. Çalışmada en sık görülen kanser tipi bazal hücreli karsinomdu ve bunu ikinci sırada skuamoz hücreli karsinom izlemekteydi. En az görülen Merkel hücreli karsinomdu. Merkel hücreli karsinom dışında erkek cinsiyet daha baskındı. Yaş ortalaması en genç olan grup kutanöz lenfomalarken, en ileri yaş gruplu tümör skuamoz hücreli karsinomdu.
Exploring processes of change in a life-design career development intervention in socio-economically challenged youth
Authors: Albien Anouk J.
Published: October 2020

Previous research has sought to identify the underlying processes and mechanisms that lead to lasting changes in a client’s career development, yet more research needed to understand what elicits effective changes. The present research will explore how life-design career counselling supports change in a group of disadvantaged South African adolescents. The present research study will focus on a post-intervention qualitative strand, which included evaluative worksheets completed post-intervention (n = 265) and a focus data six months later (n = 6). Braun and Clarke’s (2006) content analysis was used to group themes according to the Career Construction Theory (CCT) and process constructs of narrative career counselling. Qualitative findings provide evidence that the intervention had elicited long-term changes in career development and facilitated reflective processes. Implications and recommendations for research and practice will be discussed.
Understanding guidance counselling needs of adults with dyslexia through the lens of a critical-recognitive social justice perspective and a biopsychosocial model of disability
Authors: Elftorp Petra , Hearne Lucy
Published: October 2020

This article draws on the findings from a qualitatively-led sequential mixed methods doctorate study which was located within the Irish Adult Educational Guidance Services (AEGS) and focused on the guidance counselling needs of adults with dyslexia. Honneth’s (2003) conceptions of recognition, equality and social justice, and the interactionist and nonreductionist biopsychosocial (BPS) model of disability (WHO 2011) provided an opportunity to examine and interpret the findings as matters of social justice. The wider application of Honneth’s theory and the BPS model to career counselling practice are also considered.
PERJUANGAN PEREMPUAN DALAM ARENA POLITIK (STUDI PEMILIHAN ANGGOTA DEWAN PERWAKILAN RAKYAT DAERAH DI KABUPATEN MIMIKA, PROPINSI PAPUA DALAM PRESPEKTIF PIERRE BOURDIUE)
Authors: Wadanubun Sopia , Susanti Antik Tri , Kudubun Elly E.
Published: October 2020

Women are constructed as second-class creatures. This prejudice then gets reinforced in the moral structure of society manifested in religious and customary regulations. However, in the political arena an effirmative policy has been set up by giving a 30% quota of permaan. This study wants to find out how women struggle in the political arena, using the perspective of Pierre Bourdieu. The approach used in this study is a qualitative research approach, which is a research procedure that produces descriptive data using interview, observation, and document utilization techniques. This study concludes that gender is not a matter of unsuccessful person in the election stage. This means that men and women have the same opportunity to be chosen. Election is determined by the amount of economic capital. Because economic capital is the dominant determinant of victory, not because of the issue of women's struggle, in practice it can be predicted that the struggle against women's rights will not have a place in the political arena in Mimika Regency, Papua Province.

Keywords: Women, Politics, Arena, Pierre Bourdieu, Capital
 
Abstrak

Perempuan dikonstruksikan sebagai makhluk kelas dua, prasangka ini kemudian mendapatkan penguatan dalam struktur moral masyarakat yang terwujud dalam peraturan-peraturan agama maupun adat, namun demikian dalam arena politik telah di tetapkan kebijakan affirmative dengan memberi perempuan tkuota 30%.Penelitian ini ingin mengetahui bagaimana perjuangan perempuan dalam arena politik, dengan menggunakan perspektif Pierre Bourdiue, pendekatan yang di lakukan dalam penilitian ini adalah jenis pendekatan penelitian kualitatis yaitu suatu prosedur penelitian yang menghasilkan data deskriptif menggunakan teknik wawancara, pengamatan dan pemanfaatan dokumen.Penelitian ini menyimpulkan bahwa gender bukan merupakan persoalan ketidak berhasilan seseorang dalam tahap pemilihan, artinya laki-laki dan perempuan mempunyai peluang yang sama untuk di pilih. Tentununya keterpilihan seseorang di tentukan oleh jumlah modal ekonomi.

Kata kunci : Perempuan,Politik, Pierre Bourdiue, Modal
Targeted exome sequencing identified a novel USH2A mutation in a Chinese Usher syndrome family: a case report
Authors: Xing Dongjun , Zhou Huaiyu , Yu Rongguo , Wang Linni , Hu Liying , Li Zhiqing , Li Xiaorong
Published: October 2020

Abstract
Background: Usher syndrome is a disease with a heterogeneous phenotype and genotype. Our purpose was to identify the gene mutation in a Chinese family with Usher syndrome type 2 and describe the clinical features.
Case presentation: A 23-year-old man complained of a 10-year duration of nyctalopia and a 3-year decline in visual acuity of both eyes accompanied by congenital dysaudia. To clarify the diagnosis, the clinical symptoms were observed and analysed in combination with comprehensive ophthalmologic examinations as well as genetic analysis (targeted exome sequencing, TES). A typical clinical presentation of Usher syndrome of the fundus was found, including a waxy yellow-like disc, bone-spicule formations and retinal vessel stenosis. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) showed loss of the ellipsoid zone and a reduction in paracaval vessel density in both eyes. Genetic analysis identified a novel homozygous c.8483_8486del (p.Ser2828*) mutation in USH2A. The mutation resulted in premature termination of translation and caused the deletion of 19 fibronectin type 3 domains (FN3), transmembrane (TM) regions and PDZ-binding motif domains, which play an important role in protein binding. After combining the clinical manifestations and genetic results, the patient was diagnosed with Usher syndrome type 2.
Conclusion: We found a novel c.8483_8486del mutation in the USH2A gene through TES techniques. The results broaden the spectrum of mutations in Usher syndrome type 2 and suggest that a combination of clinical information and molecular diagnosis via TES could help Usher syndrome patients obtain a better diagnosis.
What Matters to Patients? A Mixed Method Study of the Importance and Consideration of Patient Demands
Authors: waelli mathias , Minvielle Etienne , Acero Maria Ximena , Aribi Khouloud Ben , Lalloue Benoit
Published: October 2020

A patient-centred approach is increasingly the mandate for healthcare delivery. A relevant but often overlooked obstacle to it is the identification and consideration of all demands based on individual experience, not only disease-based requirements. Mindful of this approach, there is a need to explore how patient demands are expressed and considered in healthcare delivery systems.
This study aims to: (i) understand how different types of demands expressed by patients are taken into account in the current delivery systems operated by Health Care Organisations (HCOs); (ii) explore the often overlooked content of specific non-clinical demands (i.e. demands related to interactions between disease treatments and everyday life).
We adopted a mixed method in two cancer centres, representing exemplary cases of organisational transformation: (i) circulation of a questionnaire to assess the importance that patients attach to every clinical (C) and non-clinical (NC) demand identified in an exploratory inquiry, and the extent to which each demand has been taken into account based on individual experiences; (ii) a qualitative analysis based on semi-structured interviews exploring the content of specific NC demands.
Further to the way in which the questionnaires were answered (573 answers/680 questionnaires printed) and the semi-structured interviews (36) with cancer patients, results show that NC demands are deemed by patients to be almost as important as C demands (C = 6.53/7 VS. NC = 6.13), but are perceived to be considered to less of an extent in terms of pathway management (NC = 4.02 VS C = 5.65), with a significant variation depending on the type of non-clinical demands expressed. Five types of NC demands can be identified: demands relating to daily life, alternative medicine, structure of the treatment pathway, administrative and logistic assistance and demands relating to new technologies.
This study shows that HCOs should be able to consider non-clinical demands in addition to those referring to clinical needs. These demands require revision of the healthcare professionals’ mandate and transition from a supply-orientated system towards a demand-driven approach throughout the care pathway. Other sectors have developed hospitality management, mass customisation and personalisation to scale up approaches that could serve as inspiring examples.
Stakeholders’ Perceptions of the Nutrition and Dietetics Needs and the Requisite Professional Competencies in Uganda: A Cross-Sectional Mixed Methods Study
Authors: Kikomeko Peterson Kato , Ochola Sophie , Kaaya Archileo N. , Ogada Irene , Birungi Tracy Lukiya , Nakitto Peace
Published: October 2020

Background: Effective implementation of nutrition and dietetics interventions necessitates professionals in these fields to possess the requisite competencies for health systems performance. This study explored the stakeholders’ perceptions of the community nutrition and dietetics needs, the nature of work done by graduates of the Bachelor’s degree in Human Nutrition/Human Nutrition and Dietetics (HN/HND), and the competencies required of Nutrition and Dietetics professionals in Uganda. Methods: A cross-sectional mixed methods design was used. Respondents included 132 graduates of the Bachelor’s degrees in HN/HND obtained from the Makerere and Kyambogo Universities in 2005-2016; 14 academic staff that train HN/HND in the two universities; and 11 HN/HND work/internship supervisors. Data from the graduates was collected through an email-based survey; data from other participants was through face to face interviews using researcher administered questionnaires. Results: Most HN/HND respondents (84.8%) obtained their Bachelor's degrees from Kyambogo University; 61.4% graduated in 2013-2016. Most (64.3%) academic staff respondents were females and the majority (57.1%) had doctorate training. All stakeholders viewed communities as facing a variety of nutrition and dietetics challenges cutting across different Sustainable Development Goals. The nutrition and dietetics interventions requested for, provided, and considered a priority for communities were both nutrition-specific and nutrition-sensitive. Work done by HN/HND graduates encompassed seven main competency domains; the dominant being organizational leadership and management; management of nutrition-related disease conditions; nutrition and health promotion; research; and advocacy, communication, and awareness creation. Conclusions: This study shows that nutrition and dietetics challenges in Uganda are multifaceted. HN/HND graduates are employed in different sectors; provide nutrition-specific and sensitive services in a multisectoral environment; are expected to possess a variety of knowledge and skills. However, graduates have knowledge and skills gaps in some areas they are expected to exhibit competency. We recommend using these findings as a basis for obtaining stakeholder consensus on the key competencies that should be exhibited by all HN/HND graduates in Uganda; developing a HN/HND competency-based education model and a national HN/HND training and practice standard, and undertaking further research to understand the quality and relevancy of HN/HND curricula to Uganda’s job market requirements.
Comparison of levonorgestrel level and creamatocrit in milk following immediate vs. delayed postpartum placement of the levonorgestrel IUD
Authors: Hopelian Niaree , Simmons Rebecca G. , Sanders Jessica N , Ward Katherine , Jenkins Sabrina Malone , Espey Eve , Turok David K
Published: October 2020

Background: Breastfeeding and postpartum contraception critically influence infant and maternal health outcomes. In this pilot study, we explore the effects of timing and duration of postpartum levonorgestrel exposure on milk lipid and levonorgestrel content to establish baseline data for future research.
Methods: This sub-study recruited a balanced convenience sample from 259 participants enrolled in a parent randomized controlled trial comparing immediate to delayed (4-8 weeks) postpartum levonorgestrel IUD placement. All planned to breastfeed, self-selected for sub-study participation, and provided the first sample at 4-8 weeks postpartum (before IUD placement for the delayed group) and the second four weeks later. We used the Wilcoxon rank sum (inter-group) and signed rank (intra-group) tests to compare milk lipid content (creamatocrit) and levonorgestrel levels between groups and time points.
Results: We recruited 15 participants from the immediate group and 17 from the delayed group with 10 and 12, respectively, providing both early and late samples. Initially, median levonorgestrel concentration of the immediate group (n=10) (32.5 pg/mL, IQR : 24.8, 59.4) exceeded that of the delayed group (n=12) (17.5 pg/mL, IQR : 0.0, 25.8) (p=0.01). Four weeks later, the values aligned: 26.2 pg/mL ( IQR : 20.3, 37.3) vs. 28.0 pg/mL ( IQR : 25.2, 40.8). Creamatocrits were similar between both groups and timepoints.
Conclusions : Immediate postpartum levonorgestrel IUD placement results in steady, low levels of levonorgestrel in milk without apparent effects on lipid content. These findings provide initial support for the safety of immediate postpartum levonorgestrel IUD initiation, though the study was not powered to detect noninferiority between groups.
Trial Registration: This randomized controlled trial was registered with ClinicalTrials.gov (registry number NCT01990703) on November 21, 2013.
OphthatomeTM: An integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic
Authors: Raj Praveen , Tejwani Sushma , Sudha Dandayudhapani , B Muthu Narayanan , Thangapandi Chandrasekar , Das Sankar , J Somasekar , Mangalapudi Susmithasane , Kumar Durgesh , Pindipappanahalli Narendra , Shetty Rohit , Ghosh Arkashubra , Kumaramanickavel Govindasamy , Chaudhuri Amitabha , Nagaswamy Soumittra
Published: October 2020

Abstract
Background: Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progression and management, disease surveillance, overall impact on public health and research. Although, the electronic medical records (EMR) system is the digital storehouse of rich medical data of a large patient cohort collected over many years, the data lack sufficient structure to be of clinical value for applying deep learning methods and advanced analytics to improve disease management at an individual patient level or for the discipline in general. Ophthatome TM captures data contained in retrospective electronic medical records between September 2012 and January 2018 to facilitate translational vision research through a knowledgebase of ophthalmic diseases.
Methods: The electronic medical records data from Narayana Nethralaya ophthalmic hospital recorded in the MS-SQL database was mapped and programmatically transferred to MySQL. The captured data was manually curated to preserve data integrity and accuracy. The data was stored in MySQL database management system for ease of visualization, advanced search functions and other knowledgebase applications.
Results: Ophthatome TM is a comprehensive and accurate knowledgebase of ophthalmic diseases containing curated clinical, treatment and imaging data of 581,466 ophthalmic subjects from the Indian population, recorded between September 2012 and January 2018. Ophthatome TM provides filters and Boolean searches with operators and modifiers that allow selection of specific cohorts covering 524 distinct ophthalmic disease types and 1800 disease sub-types across 35 different anatomical regions of the eye. The availability of longitudinal data for about 300,000 subjects provides additional opportunity to perform clinical research on disease progression and management including drug responses and management outcomes. The knowledgebase captures ophthalmic diseases in a genetically diverse population providing opportunity to study genetic and environmental factors contributing to or influencing ophthalmic diseases.
Conclusion: Ophthatome TM will accelerate clinical, genomic, pharmacogenomic and advanced translational research in ophthalmology and vision sciences.
Key words: Ophthatome, knowledge base, electronic medical records, curated clinical data, defined cohort, vision sciences