bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KUNJUNGAN WISATAWAN DI OBJEK WISATA PANTAI SWARANGAN KECAMATAN JORONG KABUPATEN TANAH LAUT PROVINSI KALIMANTAN SELATAN
Authors: Munawati Munawati , Normelani Ellyn , Arisanty Deasy
Published: May 2020

Pantai merupakan salah satu objek wisata yang banyak dikunjungi wisatawan karena memiliki daya tarik wisata. Daya tarik tersebut ditunjang oleh sarana dan prasarana seperti berenang, memancing, menyelam, dan olahraga air lainnya, termasuk sarana dan prasarana akomodasi, makan dan minum. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi kunjungan wisatawan di objek wisata Pantai Swarangan Kecamatan Jorong Kabupaten Tanah Laut Provinsi Kalimantan Selatan. Sampel dalam penelitian ini sebanyak 93 sampel dari populasi 1383,7 pengunjung. Jumlah pengunjung di objek wisata pantai swarangan dari tahun 2013, 2014 dan 2015 menurun. Metode penelitian yang digunakan yaitu dengan menggunakan metode analisis data primer dan analisis data sekunder. Data primer diperoleh dari observasi dilapangan dan pengambilan sampel pegunjung dengan kuisioner. Data sekunder diperoleh dari studi dokumen dan studi pustaka. Teknik analisis data yang digunakan adalah teknik accidental sampling. Hasil penelitian yang diperoleh dalam mengidentifikasi faktor-faktor yang mempengaruhi kunjungan wisatawan di objek wisata Pantai Swarangan Kecamatan Jorong Kabupaten Tanah Laut Provinsi Kalimantan Selatan yang melibatkan 4 variabel. Hasil pengolahan menggunakan analisis crosstabs dengan uji chi-square menunjukkan bahwa terdapat 3 faktor yang memiliki pengaruh tehadap kunjungan wisatawan (Y) yaitu faktor pendapatan (X1), faktor biaya perjalanan (X2), dan faktor fasilitas (X4).
ANALISIS PETA PERSEBARAN TITIK API UNTUK KESESUAIAN PERSEBARAN SUMUR BOR DI KECAMATAN LANDASAN ULIN KOTA BANJARBARU KALIMANTAN SELATAN
Authors: Mubarak Zaki , Kumalawati Rosalina , Adyatma Sidharta
Published: May 2020

Kebakaran rutin di hutan dan lahan gambut terjadi hampir setiap tahun. Pencegahan atau mengatasi kebakaran di lahan gambut adalah dengan cara pembasahan lahan gambut dengan memompa air dari bawah tanah atau dari badan air sekitarnya. Tujuan dalam penelitian ini adalah menganalisis peta persebaran titik api dan persebaran sumur bor untuk bencana kebakaran hutan dan lahan di Kecamatan Landasan Ulin Kota Banjarbaru. Metode dalam penelitian ini menggunakan Metode Survey. Populasi dan sampel dalam penelitian ini adalah persebaran titik api dan sumur bor di Kecamatan Landasan ulin. Data primer yang digunakan dalam penelitian ini adalah observasi berdasarkan dokumen dari intansi/jurnal dan wawancara terhadap warga sekitar. Data sekunder didapat dari pemerintahan daerah Provinsi Kalimantan Selatan Kota Banjarbaru Kecamatan Landasan Ulin. Hasil yang diperoleh dari penelitian ini adalah Kecamatan Landasan Ulin pada tahun 2015- juli 2017 menurut data persebaran titik api berjumlah 17 titik api. Titik api tersebar disemua Kelurahan di Kecamatan Landasan Ulin. Sumur bor untuk mengatasi kebakaran hutan dan lahan berjumlah 50 sumur bor yang tersebar di Kelurahan Guntung Payung dan Kelurahan Syamsudinnor. Lokasi sumur bor yang diolah sudah sesuai dengan persebaran titik api yang rawan terjadi kebakaran hutan dan  lahan. Daerah Kelurahan Guntung Manggis dan Kelurahan Landasan Ulin Timur perlu dibangun beberapa sumur bor untuk antisipasi terjadinya kebakaran hutan dan lahan.
FAKTOR - FAKTOR YANG MEMPENGARUHI PRODUKSI PADI DI KECAMATAN ANJIR PASAR KABUPATEN BARITIO KUALA
Authors: Hadnandi Hadnandi , Kumalawati Rosalina , Arisanty Deasy
Published: May 2020

Tujuan penelitian adalah menganalisis faktor-faktor yang mempengaruhi produksi padi di Kecamatan Anjir Pasar Kabupaten Barito Kuala dan untuk mengetahui faktor yang berpengaruh signifikan terhadap produksi padi di Kecamatan Anjir Pasar Kabupaten Barito Kuala. Metode analisis yang digunakan dalam penelitian faktor-faktor yang mempengaruhi produksi padi di Kecamatan Anjir Pasar Kabupaten Barito Kuala yaitu menggunakan metode analisis persentase (%), skoring dan regresi linier berganda. Hasil yang diperoleh dalam penelitian adalah faktor tenaga kerja (X1), lahan pertanian (X2), modal (X3), bibit (X4), pupuk (X5) dan pestisida (X6) secara simultan berpengaruh signifikan terhadap produksi padi di Kecamatan Anjir Pasar Kabupaten Barito Kuala, namun ada beberapa faktor yang berpengaruh signifikan terhadap produksi padi yaitu faktor tenaga kerja, lahan pertanian, bibit dan pestisida. Peningkatan produksi padi dapat dipertahankan apabila petani beserta pemerintah setempat bekerjasama mencari solusi untuk mengupayakan berbagai tindakan yang dapat meningkatkan potensi produksi padi Kecamatan Anjir Pasar Kabupaten Barito Kuala.
PENGEMBANGAN TERMINAL HANDIL BAKTI KEC. ALALAK KABUPATEN BARITO KUALA METODE ANALISIS SWOT
Authors: Zainal Akhmad , Adyatma Sidharta , Arisanty Deasy
Published: May 2020

Penelitian ini berjudul “Pengembangan Terminal Handil Bakti Kecamatan Alalak Kabupaten Barito Kuala metode Analisi SWOT ”.Metode yang digunakan adalah metode deskripti fkuantitatif. Populasi dalam penelitian ini adalah jumlah supir dan penumpang AKAP/AKDP  yang ada di Terminal Handil bakti sebanyak 83 orang. Sampel penelitian ini adalah  supir  dan  penumpang  yanga  ada  diterminal  handil  bakti  selama  satu  minggu penelitian. Teknik pengumpulan data adalah data primer dan sekunder diperoleh dari studi dokumen dan studi literatur. Hasil  penelitian  ini  menyimpulkan bahwa  Pengembangan terminal  Handil  bakti masih terbuka lebar dengan adanya Kekuatan (strength) yang bias dilihat dari sudah baiknya penanganan permasalahan di  terminal, jumlah  petugas  yang sudah mencukupi, fasilitas terminal yang sudah terpelihara, keadaan terminal yang bersih dan nyaman dan biaya tiket yang sudah sesuai dengan peraturan pemerintah, sedangkan pada sisi peluang (opportunity) adalah tingginya tingkat kebutuhan masyarakat akan transportasi umum jarak jauh (> 20 km) yang cukup tinggi, kecendrungan masyarakat akan transportasi murah dan aman asalkan mudah dijangkau dan tidak jauh dari tempat tinggalnya. Kelemahan  terminal Handil bakti terletak pada lemahnya pelaksanaan dan rendahnya respon terhadap pelanggaran peraturan pemerintah serta  keterbatasan lahan  parkir  merupakan kelemahan  yang  harus dicarikan solusinya.
HUBUNGAN KECERDASAN EMOSIONAL DENGAN MINAT BELAJAR SISWA PADA MATA PELAJARAN IPS DI KELAS VIII SMP NEGERI 1 LOKSADO KABUPATEN HULU SUNGAI SELATAN
Authors: Abdi Rosadi , Kumalawati Rosalina , Arisanty Deasy
Published: May 2020

Proses belajar dan mengajar tidak lepas dari berbagai permasalahan dalam mencapai tujuan pembelajaran. Permasalahan yang umum ditemukan adalah minat siswa yang rendah dalam memahami mata pelajara Ilmu Pengetahuan Sosial. Pada penerapan kurikulum 2013 tingkat Intelegensi (IQ) tidak menjadi acuan utama keberhasilan belajar siswa tetapi tingkat kecerdasan emosi yang lebih ditekankan dalam proses belajar. Kecerdasan emosi yang baik dapat menentukan keberhasilan siswa dalam belajar, membangun kesuksesan karir, dan dapat mengurangi agresivitas khususnya dalam kalangan remaja Tujuan penelitian untuk mengetahui korelasi antara kecerdasan emosional dan minat belajar siswa terhadap mata pelajaran Ilmu Pengetahuan Sosial di kelas VIII SMP Negeri 1Loksado.            Data yang digunakan dalam penelitian ini adalah data primer berupa hasil kuesioner skala kecerdasan emosional dan data sekunder berupa nilai rapor yang dianalisis menggunakan metode korelasi dengan aplikasi SPSS 21.01. Penelitian menggunakan pendekatan deskriptif kuantitatif dengan sampel seluruh siswa kelas VIII SMP Negeri 1Loksado sebanyak 120 siswa.            Hasil penelitian menunjukkan adanya hubungan antara kecerdasan emosional dengan minat belajar siswa dengan nilai korelasi sebesar 0.668. Hubungan kecerdasan emosional dan minat belajar yang kuat akan membuat minat belajar menjadi lebih baik dan bermanfaat bagi perkembangan prestasi belajar siswa.
KAJIAN SPASIAL DAMPAK AKTIVITAS PARIWISATA TERHADAP PERUBAHAN SOSIAL EKONOMI DI KECAMATAN PRAMBANAN, KABUPATEN KLATEN
Authors: Kusuma Aditya Andre , Wulandari Maharani Retno , Meitawati Ratna Dyah Ayu , Sochiba Salma Lutfiani , Trenggono Danan Puja , Putri Deviana Kusuma
Published: May 2020

Masyarakat Kecamatan Prambanan adalah masyarakat yang banyak terkena dampak adanya objek wisata Candi Prambanan. Penelitian ini bertujuan untuk mengetahui kajian spasial dampak aktivitas pariwisata objek wisata Candi Prambanan terhadap kehidupan sosial ekonomi masyarakat Prambanan. Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif kualitatif. Teknik pengumpulan data menggunakan wawancara, observasi lapangan, dokumentasi. Teknik pemilihan responden menggunakan teknik random sampling yang dipetakan berdasarkan citra satelit Kecamatan Prambanan. Proses analisis data menggunakan analisis model interaktif mulai dari pengumpulan data, reduksi data, penyajian data, hingga proses penarikan kesimpulan. Hasil penelitian menunjukkan bahwa sebagian besar masyarakat sudah merasakan manfaat dari adanya objek wisata di Kecamatan Prambanan. Manfaat pariwisata yang berada di Kecamatan Prambanan yang banyak mempengaruhi tingkat pengetahuan responden. Tingkat pendapatan setelah adanya pariwisata di Kecamatan Prambanan, sebagian besar desa di Kecamatan Prambanan memiliki pendapatan dengan rata-rata 0 – Rp 500.000. Berdasarkan hasil analisis peta kajian spasial dampak pariwisata terhadap Kecamatan Prambanan desa-desa yang memiliki dampak wisata tidak signifikan terhadap sosial ekonomi. Dampak dari pariwisata tidak hanya terdapat di desa yang dekat dengan pariwisata tetapi juga terdampak ke desa yang jauh dari lokasi objek wisata.
IMPLEMENTASI PENDEKATAN KONTEKSTUAL DALAM PEMBELAJARAN GEOGRAFI (STUDI DESKRIPTIF PADA SISWA KELAS XI IPS 4 SMA NEGERI 4 PEKANBARU)
Authors: Syofniati Syofniati
Published: May 2020

Aspek pembinaan penguasaan unsur-unsur Geografi yang dapat dilakukan di sekolah misalnya pengenalan letak suatu wilayah, bentuk permukaan bumi, dan sumber daya alam. Penerapan pengetahuan Geografi secara benar, maka kualitas penguasaan siswa atas materi Geografi harus ditingkatkan. Peningkatan pemahaman siswa dapat dilakukan dengan menerapkan pembelajaran kontekstual. Siswa dihubungkan langsung dengan keadaan nyata kondisi di lingkungannya. Di samping itu bidang studi Geografi sangat memungkinkan untuk didesain dengan pembelajaran kontekstual karena berhubungan dengan berbagai fenomena fisik dan sosial yang ada di sekitar lingkungan siswa itu sendiri. Penelitian tindakan kelas ini dilakukan pada kelas XI IPS 4 SMA Negeri 4 Pekanbaru. Penelitian ini bertujuan untuk meningkatkan aktivitas dan hasil belajar peserta didik. Metode yang digunakan dalam penelitian ini adalah Penelitan Tindakan Kelas dengan menggunakan pendekatan dua siklus. Berdasarkan hasil penelitian, metode pembelajaran Kontekstual pada pembelajaran Geografi dapat meningkatkan aktivitas dan hasil belajar siswa kelas XI IPS 4 SMA Negeri 4 Pekanbaru secara signifikan. Kata kunci: Pendekatan Kontekstual, Pembelajaran, Geografi
IDENTIFIKASI FAKTOR PENYEBAB GERAKAN MASSA (MASS MOVEMENT) DI KECAMATAN AWAYAN KABUPATEN BALANGAN
Authors: Muslimah Wilda , Arisanty Deasy , Adyatma Sidharta
Published: May 2020

Gerakan Massa adalah gerakan material pembentuk lereng yang berupa tanah, batu, yang bergerak ke arahbawah. Potensi gerakan massa merupakan kemungkinan suatu daerah dapat mengalami kejadian longsor atau gerakan massa. Mengetahui faktor penyebab gerakan massa di Kecamatan Awayan Kabupaten Balangan Provinsi Kalimantan Selatan, dan potensi gerakan massa merupakan tujuan dari penelitian ini. Metode penelitian ini menggunakan metode survei dan skoring. Parameter faktor penyebab gerakan massa antara lain: kemiringan lereng, tekstur tanah, kedalaman efektif tanah, penggunaan lahan, kerapatan vegetasi, dan curah hujan. Potensi gerakan massa di Kecamatan Awayan terbagi dalam 3 golongan yaitu gerakan massa sangat rendah, rendah dan sedang. Potensi gerakan massa sangat rendah terdapat 3 kasus, potensi gerakan massa rendah terdapat 1 kasus dan potensi gerakan massa 1 kasus. Faktor penyebab yang paling dominan berdasarkan jumlah skoring adalah tekstur tanah dan kerapatan vegetasi.Kata kunci: Gerakan massa, potensi gerakan massa, faktor penyebab gerakan massa
TINGKAT KERENTANAN LONGSORLAHAN DI KECAMATAN PADANG BATUNG KABUPATEN HULU SUNGAI SELATAN
Authors: Mahdina Lini , Adyatma Sidharta , Nasruddin Nasruddin
Published: May 2020

Penelitian ini bertujuan untuk mengetahui tingkat kerentanan longsorlahan di Kecamatan Padang Batung Kabupaten Hulu Sungai Selatan. Populasi dan  sampel dalam penelitian ini adalah  9 bentuklahan dengan  luas 203,93 Km² yang diperoleh dari interpretasi citra landsat 8. Penentuan tingkat kerentanan longsorlahan menggunakan 9 variabel yang mempengaruhi longsorlahan, yaitu: 1) kemiringan lereng, 2) tekstur tanah, 3) permeabilitas tanah, 4) kedalaman muka air tanah, 5) kedalaman efektif tanah. 6) kerapatan vegetasi, 7) curah hujan, 8) kejadian longsor sebelumnya, 9) penggunaan lahan. Data yang digunakan terdiri dari data primer dan sekunder. Data primer diperoleh dari observasi lapangan, pengambilan sampel tanah yang akan dianalisis dilaboratorium. Data sekunder diperoleh dari studi dokumen dari instansi terkait. Teknik analisis data yang digunakan adalah metode pengharkatan (scoring). Hasil penelitian tingkat kerentanan longsorlahan menunjukkan bahwa di Kecamatan Padang Batung, Kabupaten Hulu Sungai Selatan memiliki tiga tingkat kerentanan longsorlahan yaitu rendah, sedang dan tinggi.Kata kunci: Kerentanan, Longsorlahan, Bentuklahan, Pengharkatan
ANALISIS KOMODITAS UNGGULAN PERTANIAN DI KABUPATEN BANJAR
Authors: Fauzia Ulfa , Adyatma Sidharta , Arisanty Deasy
Published: May 2020

Penelitian ini bertujuan untuk mengetahui komoditi sektor pertanian basis (unggulan) yang mempunyai pertumbuhan cepat di masing-masing kecamatan di Kabupaten Banjar dan mengetahui komoditi pertanian basis yang diprioritaskan untuk dikembangkan di masing-masing kecamatan di Kabupaten Banjar. Ruang lingkup penelitian ini mencakup sub sektor tanaman pangan, holtikultura, perkebunan, peternakan dan perikanan. Data yang digunakan dalam penelitian ini adalah data sekunder yang meliputi produksi sektor pertanian yang mencakup sub sektor tanaman pangan, holtikultura, perkebunan, peternakan dan perikanan setiap kecamatan di Kabupaten Banjar dengan time series 5 tahun. Metode analisis data yang digunakan yaitu Location Quotient (LQ) dan analisis Shift Share.Hasil penelitian menunjukan komoditi pertanian yang menjadi basis di sebagian kecamatan di Kabupaten Banjar untuk sub sektor tanaman pangan dengan komoditi unggulan yaitu padi sawah, padi ladang, jagung, kedelai, kacang tanah, kacang, hijau, ubi kayu dan ubi jalar. Sub sektor holtikultura buah-buahan dengan komoditi unggulan yaitu alpukat, belimbing, duku / langsat, durian, jambu biji, jeruk siam / keprok, jeruk besar, mangga, nangka, nenas, pepaya, pisang, rambutan, salak, sawo, sirsak, sukun, melinjo, petai dan jengkol. Sub sektor holtikultura sayur-sayuran dengan komoditi unggulan yaitu kacang panjang, cabe besar, cabe rawit, tomat, terung, buncis, ketimun, kangkung, bayam dan semangka. Sub sektor perkebunan dengan komoditi unggulan yaitu kelapa dalam, kelapa sawit, kopi, lada, jambu mete, sagu / rumbia, kemiri, pinang, kapuk, kenanga dan aren. Sub sektor peternakan dengan komoditi unggulan yaitu sapi, kuda, kerbau, ayam pedaging dan itik. Sub sektor perikanan dengan komoditi unggulan yaitu perikanan darat dan budidaya. Kata Kunci: Analisis Komoditas Unggulan, Location Quetient, Analisis Shift Share
POTENSI PENCEMARAN AKTIVITAS KERAMBA JARING APUNG (KJA) TERHADAP SUNGAI MARTAPURA DI KELURAHAN BENUA ANYAR BANJARMASIN TIMUR
Authors: Mulyani Yulisa , Arisanty Deasy , Adyatma Sidharta
Published: May 2020

Penelitian ini bertujuan untuk mengetahui kualitas air terhadap aktivitas keramba jaring apung (KJA) di Sungai Martapura di tinjau dari sifat fisik dan kimia. Penentuan lokasi di bagi menjadi 5 titik dengan kedalaman 0,2, 0,6 dan 0,8. Teknik analisis data yang digunakan adalah Metode MPN yaitu: pengujian perkiraan, pengujian penegasan dan pengujian lengkap yang dilakukan oleh pihak laboratorium.Hasil penelitian dari pengukuran kualitas air saat pasang surut dan pasang naik kedalaman 0,2, 0,6 dan 0,8. Parameter fisik yaitu suhu berkisar 23 - 30oC saat pasang surut  titik S2 kedalaman 0,2, 0,6 dan 0,8 suhu airnya rendah yaitu 23 oC. Warna air saat pasang surut berwarna dikarenakan saat pasang surut kedalaman air 0,5 m saat pasang naik air sungai tidak berwarna. Bau air saat pasang surut dan pasang naik titik S0 dan S4 tidak berbau sedangkan titik S1, S2 dan S3 berbau .Kekeruhan air normal berkisar antara 0,12 - 1,39. Rasa air sungai saat pasang surut dan pasang naik berasa. Parameter kimia dibandingkan dengan Peraturan Gubernur Kalimantan Selatan No. 5 Tahun 2007 yaitu amoniak, 0,05 mg/l - 0,3 mg/l melebihi kandungan maksimum kelas III yaitu (0,02 mg/l). Nitrit saat pasang surut dan pasang naik berkisar berkisar 0,006 mg/l - 0,011mg/l saat pasang surut nitrit melebihi kandungan maksimum kelas III yaitu (0,006 mg/l), saat pasang naik titik S0 kedalaman 0,2, 0,6 dan 0,8 tidak melebihi kandungan maksimum. Nitrat saat pasang surut dan pasang naik berkisar 0,1 mg/l – 0,7 mg/l tidak melebihi kandungan maksimum kelas III yaitu (20 mg/l).  DO 0,2 – 4 mg/l saat pasang surut titik S1, S2 kedalaman 0,2 titik S2 dan S3 kedalaman 0,6 dan 0,8 melebihi kandungan maksimum kelas III yaitu (3 mg/l) saat pasang naik titik S0, S1, S2, S3 kedalaman 0,2, titik S0, S3 kedalaman 0,6 dan titik S3 kedalaman 0,8 melebihi kandungan maksimum kelas III yaitu (3 mg/l). pH berkisar 6 – 7 saat pasang surut bersifat basa sedangkan saat pasang naik termasuk larutan asam.Kata Kunci : Pencemaran, Kualitas Air, Keramba Jaring Apung (KJA)
Saccharomyces uvarum yeast isolate consumes acetic acid during fermentation of high sugar juice and juice with high starting volatile acidity
Authors: Inglis Debra , Kelly Jennifer , Van Dyk Stephanie , Dowling Lisa , Pickering Gary , Kemp Belinda
Published: May 2020

Aim: A Saccharomyces uvarum isolate was assessed for its ability to metabolize acetic acid present in juice and during the fermentation of partially dehydrated grapes. The impact on other yeast metabolites was also compared using an S. uvarum isolate and an S. cerevisiae wine yeast. The upper limit of fruit concentration that allowed the S. uvarum isolate to ferment wines to < 5 g/L residual sugar was defined.Methods and results: Cabernet franc grapes were partially dehydrated to three different post-harvest sugar targets (24.5 °Brix, 26.0 °Brix, and 27.5 °Brix) along with non-dehydrated grapes (21.5 °Brix control). Musts from all treatments were vinified with either the S. uvarum isolate CN1, formerly identified as S. bayanus, or S. cerevisiae EC1118. All wines were successfully vinified to less than 5 g/L residual sugar. Fermentation kinetics between the two yeasts were similar for all wines other than 27.5 °Brix, where CN1 took three days longer. During fermentation with CN1, acetic acid peaked on day two, then decreased in concentration, resulting in final wine acetic acid lower than that measured on day two. Wines fermented with EC1118 showed an increase in acetic acid over the time-course of fermentation. Significantly lower wine oxidative compounds (acetic acid, acetaldehyde and ethyl acetate) and higher glycerol resulted in wine produced with CN1 in comparison to EC1118. Both yeasts produced comparable ethanol at each Brix level tested. Further studies showed that CN1 lowered acetic acid seven-fold from 0.48 g/L in juice to 0.07 g/L in wine whereas EC1118 reduced acetic acid to 0.18 g/L.Conclusions: The autochthonous S. uvarum yeast isolate successfully fermented partially dehydrated grapes to < 5 g/L sugar up to 27.5 ºBrix. The consumption rate of acetic acid was faster than its production during fermentation, resulting in low acetic acid, acetaldehyde and ethyl acetate in wine in comparison to a commercial S. cerevisiae yeast while consistently producing higher glycerol.Significance and impact of the study: The S. uvarum yeast isolate can metabolize acetic acid during fermentation to significantly lower acetic acid, ethyl acetate and acetaldehyde in wine. It can also reduce acetic acid by seven-fold from the starting juice to the finished wine, which could have potential application for managing sour rot arising in the vineyard or during the dehydration process in making appassimento-style wines.
Development and Validation of a Shared Governance Feasibility Instrument in Nursing Schools in Iran
Authors: Sattarzadeh-Pashabeig Maryam , –Shoorideh Foroozan Atashzadeh , Sadoughi Mohammad-Mehdi , Khachian Alice , Zagheri-Tafreshi Mansoureh , Stievano Alessandro
Published: May 2020

To develop and validate a shared governance feasibility instrument in schools of nursing in Iran with respect to the nature of the profession and the sociocultural context of the Iranian community. Background: Nursing schools are liable to the application of shared governance due to the presence of various expert educational groups within the school that necessitates reciprocal cooperation. Since the concept of shared governance is culture-based and given that no full-fledged study has been conducted on shared governance in Iran, the development of a suitable shared governance feasibility instrument is rendered as mandatory. Methods: This sequential exploratory mixed method study consisted of two qualitative and quantitative parts was accomplished 2016-2019. First, the primary items were extracted through extensive review of literature and qualitative interviews and underwent psychometric validation using a methodological approach. Face, content, construct validity, reliability of the instrument was established were done. Results: 150 items were distilled from the first stage of the study, was reduced to 70 after establishing face and content validity, and primary reliability. Exploratory factor analysis resulted in 52 items covering the two factors “shared atmosphere and culture” and “infrastructural prerequisites”. These two factors accounted for 78.6% of the total variance of the questionnaire. In calculating the final reliability coefficient of the instrument, Cronbach’s alpha and Omega were 0.981 and 0.805, respectively. The results showed an ICC of 0.91 indicating high reliability of the developed instrument with standard error of measurement (SEM) of 10.43. Finally, the items underwent weighting via scoring by considering item weights due to differences between the two methods. Conclusion: “Shared governance feasibility instrument” can provide a new insight to organizational performance for all policy-makers and beneficiaries of higher education. This not only leads to the use of intelligence and capabilities of the beneficiaries, but also aids in faster movement toward achieving organizational goals. Implications for Nursing Management: This study and the developed instrument may serve as guide for the feasibility of implementing shared governance to assess management styles and performance in higher education centers.
Expression of Epithelial-Mesenchymal Transition Related Markers in Plasmacytoid Urothelial Carcinoma of the Urinary Bladder
Authors: Nomura Shunichiro , Suzuki Yasutomo , Akatsuka Jun , Endo Yuki , Shimizu Akira , Hamasaki Tsutomu , Kimura Go , Kondo Yukihiro
Published: May 2020

Background Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is a variant of urothelial carcinoma that carries a poor prognosis. The epithelial-mesenchymal transition (EMT) has been demonstrated to contribute to tumor progression. As the cause of the increased aggressiveness of PUC is unknown, we investigated PUC and EMT-related marker expression. Methods A total of 633 bladder carcinoma cases diagnosed from 2006 to 2015 at the Nippon Medical School Hospital were analyzed. Twelve patients were found to have plasmacytoid histology and diagnosed with PUC. Slides were evaluated for percentage of plasmacytoid variant, and stained for E-cadherin, N-cadherin, Vimentin, Fibronectin and Snail expression. Results The incidence of PUC was 1.9% (12/633). The median patient age at diagnosis was 71 years (range, 60–80 years) and the male-female ratio was 11:1. All but three patients had stage T2b or higher. The median overall survival was 10 months. In 10/12 cases, Snail and N-cadherin were positive. Vimentin was positive in 9/12 cases. Fibronectin was positive in 8/12 cases. While E-cadherin was negative in 10/12 cases. Nine cases showed >10% plasmacytoid component. Eight of the nine patients (88.9%) with >10% plasmacytoid component died. Conclusions The results indicate that PUC may induce EMT and may be associated with high invasion.
Simultaneous non-invasive telemetric electrocardiogram and respiratory measurement with a connected jacket (DECRO system) in rats
Authors: FARES Raafat P. , BOIRE Alexia , EYNARD Charles , FLENET Timothé
Published: May 2020

In preclinical research, animal welfare is a major foundation for relevant and high-quality data. Due to limited technology features in biomedical research, animal welfare can be impaired leading to poor-quality and irrelevant scientific data. Therefore, there is a growing interest in developing new technologies that are able to deliver satisfactory outcomes for both ethical and scientific needs in widely used species in biomedical research such as rats. A telemetric system was developed to meet these needs in the cardiorespiratory field in small animals within 180 grams-3 kilograms weight range. This system called DECRO is a non-invasive connected jacket designed to simultaneously monitor cardiac and respiratory functions, and activity while animals are unrestrained in their environment. This publication describes recommended procedure to achieve proper recording in rats using this jacket.
CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model
Authors: Tsukui Hidenori , Horie Hisanaga , Koinuma Koji , Ohzawa Hideyuki , Sakuma Yasunaru , Hosoya Yoshinori , Yamaguchi Hironori , Yoshimura Kotaro , Lefor Alan Kawarai , Sata Naohiro , KITAYAMA JOJI
Published: May 2020

Background: Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule. Method: We examined how intra-tumoral adenosine levels modify anti-tumor effects of RT in a murine model using an anti-CD73 antibody which blocks the rate-limiting enzyme to produce extracellular adenosine. We also evaluated CD73 expression in irradiated human rectal cancer tissue. Results: LuM-1, a highly metastatic murine colon cancer, expresses CD73 with significantly enhanced expression after RT. Subcutaneous (sc) transfer of LuM-1 in balb/c mice developed macroscopic sc tumors and microscopic pulmonary metastases within 2 weeks. Adenosine levels in the sc tumor were increased after RT. Selective RT (12 Gy in 3 fractions) suppressed the growth of the irradiated sc tumor, but did not affect the growth of lung metastases which were shielded from RT. Intraperitoneal administration of anti-CD73 antibody (200 mg x 6) alone did not produce antitumor effects. However, when combined with RT in the same protocol, anti-CD73 antibody further delayed the growth of sc tumors and suppressed the development of lung metastases presumably through abscopal effects. Splenocytes derived from RT+ CD73 antibody treated mice showed enhanced IFN-g production and cytotoxicity against LuM-1 compared to controls. Immunohistochemical studies of irradiated human rectal cancer showed that high expression of CD73 in remnant tumor cells and/or stroma is significantly associated with worse outcome. Conclusion: These results suggest that adenosine plays an important role in the anti-tumor effects mediated by RT and that CD73/adenosine axis blockade may enhance the anti-tumor effect of RT, and improve the outcomes of patients with locally advanced rectal cancer.
Added value of Contrast Enhanced Mammography (CEM) in staging of malignant breast lesions – a feasibility study
Authors: Åhsberg Kristina , Gardfjell Anna , Nimeus Emma , Rasmussen Rogvi , Behmer Catharina , Zackrisson Sophia , Ryden Lisa
Published: May 2020

Objectives: The aim of this feasibility study was to evaluate the added value of contrast enhanced mammography (CEM) in preoperative staging of malignant breast lesions, beyond standard assessment with digital mammography and ultrasound, as a base for a future prospective randomized trial. Materials and methods: Forty-seven patients, with confirmed or strongly suspected malignant breast lesions after standard assessment (digital mammography (DM) and ultrasound (US)), scheduled for primary surgery, were invited to undergo CEM as an additional preoperative procedure. The primary endpoint was change in treatment due to CEM findings, defined as mastectomy instead of partial mastectomy or contrariwise, bilateral surgery instead of unilateral or neoadjuvant treatment instead of primary surgery. Accuracy in tumour extent estimation compared to histopathology was evaluated by Bland Altman statistics. Number of extra biopsies and adverse events were recorded.Results: In 10/47 patients (21%), findings from CEM affected the primary treatment. Agreement with histopathology regarding extent estimation was better for CEM (mean difference -1.36, SD +/- 18.45) in comparison with DM (-4.18, SD +/- 26.20) and US (-8.36, SD +/- 24.30). Additional biopsies were taken from 19 lesions in 13 patients. Nine biopsies showed malignant outcome. No major adverse events occurred. Conclusion: The feasibility of preoperative additional CEM was found to be satisfactory without any serious negative effects. Results imply an added value of CEM in preoperative staging of breast cancer. Further evaluation in larger prospective randomized trials is needed.Trial registration: ClinicalTrials.gov., NCT03402529, Registered 18 January 2018 – Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03402529?term=NCT03402529&draw=2&rank=1
Head and neck tumors angiogenesis imaging with 68Ga-NODAGA-RGD in comparison to 18F-FDG PET/CT: A pilot study.
Authors: Durante Steve , Dunet Vincent , Gorostidi François , Mitsakis Periklis , Schaefer Niklaus , Delage Judith , Prior John O.
Published: May 2020

Background : Angiogenesis plays an important role in head and neck squamous cell carcinomas (HNSCC) progression. This pilot study was designed to compare the distribution of 68 Ga-NODAGA-RGD PET/CT for imaging α v β 3 integrins involved in tumor angiogenesis to 18 F-FDG PET/CT in patients with HNSCC. Material and methods : Ten patients (aged: 58.4 ± 8.3 years [range: 44–73 years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both 68 Ga -NODAGA-RGD and 18 F-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation. Results : All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher 18 F-FDG SUV max in comparison to 68 Ga-NODAGA-RGD (14.0 ± 6.1 versus 3.9 ± 1.1 g/mL, p=0.0017) and SUV mean (8.2 ± 3.1 versus 2.0 ± 0.8 g/mL, p=0.0017). Both 18 F-FDG and 68 Ga-NODAGA-RGD uptake were neither correlated with grade, HPV nor p16 protein expression (p≥0.17). Conclusion : All HNSCC tumors were detected with both tracers with higher uptake with 18 F-FDG, however. 68 Ga-NODAGA-RGD has a different spatial distribution than 18 F-FDG bringing different tumor information.
TA Rupture Assessment Analysis – are Our "GOLD-Standards“ of Tendon Repair Valid?
Authors: Frunz Simone , Knupp Markus , Goepfert Beat , Iselin Lukas
Published: May 2020

Background: Current studies showed that operative treatment has advantages in comparison to conservative treatment for acute Achilles tendon ruptures. The gold standard therapy in our clinic is the operative treatment with the four strand Adelaide suture. The goal of this study is to evaluate which suture material (a) B Braun; MonoMax, b) Ethicon; PDS CTX) is more appropriate for Achilles tendon suture.Methods: Ten pairs of fresh frozen Achilles tendons were obtained from human donors aged 41 – 85. The tendons were fixed on a testing machine and loaded until failure. The goal of this setup was to create a natural rupture pattern. The ruptured tendons were sutured either with BB or PDS and again loaded until failure.The failure mode in all sutured tendons was a pullout of the suture material through the tendon fibres.Results: The ruptures occurred on different locations. The maximal forces in the sutured tendons occurring at the rupture were for the BB-suture between 144 N and 232 N (Mean 197 (SD 67) N) and for the PDS-suture between 158 N and 226 N (Mean 194(SD 70) N). The failure mode in all sutured tendons was a pullout of the suture material through the tendon fibres.Conclusion: Due to the failure mode we are not able to evaluate which suture material is better to use for the Achilles tendon repair with the Adelaide suture. Either the Adelaide suture is not an appropriate suture technique for Achilles tendon repair or the natural rupture pattern has in comparison to the in vitro rupture patterns constructed by sharp dissection a bigger influence on the pullout strength of suture techniques than we thought. This would mean that probably the data from most in vitro studies are not applicable for daily life.
HPV prevalence and genotype distribution among women from Hengyang district of Hunan province, China
Authors: Tang Shuang-yang , Ding S , Yu L , Shen SY , Wan YP , Wu YM
Published: May 2020

Background Human papillomavirus (HPV) infection can cause a variety of epithelial lesions, including even various malignant cancers, such as cervical cancer, vulvar cancer and etc. Most cervical cancers were closely associated with HPV infections. Therefore, understanding the ecological diversity of HPV prevalence and genotype distribution among various populations in different geographical regions was essential for optimizing HPV vaccination and maximizing vaccination effects. Aim This study was designed to investigate HPV infection prevalence and genotype distribution among women from Hengyang district of Hunan province in China.Methods A total of 12053 patient data from the three-level hospitals in Hengyang city between July 2016 and July 2017 were retrospectively analyzed. The HPV positive was identified by Polymerase chain reaction (PCR). The HPV PCR-Flow fluorescence assay was used for HPV genotyping. The Chi-square test was performed to compare the differences among HPV infection rates or HR-HPV ratio-in-positives.Results In this study, the HPV prevalence was 10.16% overall, and the multiple-type infection rate was 1.83%. The HR-HPV infection rate was 8.52%. The top six HPV genotypes were as follows in a descending order: HPV16, HPV58, HPV52, HPV39, HPV51, and HPV53. The patients who were above 60 years and below 21 years old were the most and second HPV prevalent group, respectively, the corresponding HR-HPV infection rates were the most and the third, respectively. The infection rates of HPV and HR-HPV among outpatients were lower than those among hospitalized-patients, respectively. Among the hospitalized-patients, the infection rates of HPV and HR-HPV among 50~60 years group were both the most, following by those among above 60 years group. The HR-HPV ratio-in-positive among HPV-positive patients with histopathologic examination was higher than that among those patients without. Among 52 HPV-positive patients with cervical squamous carcinoma, the ratio-in-positive of HPV16 was 61.54%.Conclusions This study demonstrated that the HPV prevalence varied with the age among women from Hengyang district of Hunan province in China and showed their HPV genotype distribution that HPV16, HPV58, HPV52, HPV39, HPV51 and HPV53 infection were more popular in this region, which could provide the experimental basis for Chinese public health measures on cervical cancer prevention.
Alterations in articular cartilage T2 star relaxation time following mechanical disorders: in vivo canine supraspinatus tendon resection models
Authors: Lee Dokwan , Hong Ki-Taek , Lim Tae Seong , Lee Eugene , Lee Ye Hyun , Park Ji Soon , Kim Woo , Oh Joo Han , Choi Jung Ah , Song Yongnam
Published: May 2020

Background: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2* relaxation time distributions.Methods: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2* relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2* relaxation time were compared in the shoulders before and three months after the supraspinatus tendon resections.Results: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2* relaxation time after resection surgeries. Regional changes in the articular cartilage T2* relaxation time exhibited positive correlations with regional contact strain variations three months after the supraspinatus resection surgeries.Conclusion: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2* relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas.
The effect of self-care counseling on depression and anxiety in women with Endometriosis: a randomized controlled trial.
Authors: Farshi Nooshin , Hasanpour Shirin , Mirghafourvand Mojgan , Esmaeilpour Khalil
Published: May 2020

Background: Considering the prevalence of endometriosis and depression and anxiety caused by this disease and its effect on the body, mind and quality of life of patients, this study was performed to determine the effect of self-care counseling on depression and anxiety (primary outcome), and quality of life of women with endometriosis (secondary outcome). Method: This randomized controlled clinical trial was conducted on 76 women with endometriosis who were treated in Al-Zahra Teaching and Treatment Center of Tabriz between2017-2019. The patients were divided into intervention (counselling) and control groups using random blocking method. For the intervention group, self-care group counseling was held weekly for 7 sessions. The control group received routine care. The Socio-demographic Questionnaire, Beck Depression Inventory, Spline Berger Anxiety Inventory and SF36 Quality of Life Questionnaire were completed by the researcher through an interview before and four weeks after the intervention. Results: No statistically significant difference was found between the intervention and control groups in terms of socio-demographic characteristics (p>0.05). After intervention mean scores of state anxiety (mean difference: -0.12, 95% confidence interval: -9.6 to -14.4, p<0.001) and trait anxiety (mean difference: -10.9: 95% confidence interval: -9.1 to -12.7, p=0.001) were significantly lower than control group and mean score of depression in counseling group was less than control group but it was not significant (p=0/565). Mean score of quality of life in terms of physical health (mean difference= 17.2, 95% confidence interval: 13.8 to 20.5, p<0.001) and in terms of mental health mean difference = 12.0, 95% confidence interval: 9.0 to 14.9, p<0.001) were significantly upper in counselling group. Conclusion: Self-care counselling is effective on anxiety and quality of life of women with endometriosis. So in addition to other therapies, this method is recommended to improve the mental health of patients with this disease. Trial Registration: IRCT Registration Number: IRCT 20111219008459N13, registered 10 February 2019, https://irct.ir/user/trial/35915
Joint Hemorrhage Accelerates Cartilage Degeneration in a Rat Immobilized Knee Model
Authors: Sogi Yasuhito , Yabe Yutaka , Hagiwara Yoshihiro , Tsuchiya Masahiro , Onoda Yoshito , Sekiguchi Takuya , Itaya Nobuyuki , Yoshida Shinichiro , Yano Toshihisa , Suzuki Kazuaki , Onoki Takahiro , Itoi Eiji
Published: May 2020

Background: Joint hemorrhage is caused by trauma, ligament reconstruction surgery, and bleeding disorder such as hemophilia. Recurrence of hemorrhage in the joint space induces hemosiderotic synovitis as well as oxidative stress, resulting in both articular cartilage degeneration and arthropathy. Joint immobilization is a common treatment option for articular fractures accompanied by joint hemorrhage. Although it is apparent that joint hemorrhage is harmful on the articular cartilage, there was no consensus whether reduction of joint hemorrhage is effective to prevent articular cartilage degeneration. The purpose of this study was to investigate the articular cartilage degeneration induced by a combination of joint hemorrhage and joint immobilization in a rat knee model.Methods: The knee joints of adult male rats were immobilized at the flexion using an internal fixator from 3 days to 8 weeks. The rats were divided randomly into two groups: immobilized blood injection (Im-B) group and immobilized-normal saline injection (Im-NS) group. The cartilage was evaluated at two areas (contact and non-contact areas). The cartilage was assessed for the chondrocyte count, Modified Mankin score, and cartilage thickness. Total RNA was extracted from the cartilage in both areas, and gene expressions of metalloproteinase (MMP)-8, MMP-13, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α were measured by quantitative real-time polymerase chain reaction.Results: The number of chondrocytes in the Im-B group significantly decreased in both areas, compared to the Im-NS group. Modified Mankin score from 4–8 weeks of the Im-B group was significantly greater than the Im-NS group only in the contact area. Gene expressions of MMP-8 and MMP-13 from 2–4 weeks and TNF-α from 2–8 weeks significantly increased in the Im-B group compared to the Im-NS group, while there was no significant difference in IL-1β.Conclusions: This study showed that joint hemorrhage exacerbated immobilization-induced articular cartilage degeneration. Therefore, drainage of a joint hemorrhage and avoidance of loading are recommended to prevent cartilage degeneration during immobilization of a joint hemorrhage.
Modeling Count Data for Healthcare Utilization: an Empirical Study of Outpatient Visits Among Vietnamese Older People
Authors: Le Dung Duc , Leon-Gonzalez Roberto , Matola Joseph Upile
Published: May 2020

The authors have withdrawn this preprint due to erroneous posting.
Levels, Trends and Determinants of Technical Efficiency of General Hospitals in Uganda: Data Envelopment Analysis and Tobit Regression Analysis
Authors: Ayiko Rogers , Mujasi Paschal N. , Abaliwano Joyce , Turyareeba Dickson , Enyaku Rogers , Anguyo Robert , Odoch Walter , Bakibinga Pauline , Aliti Tom
Published: May 2020

Background General hospitals provide a wide range of primary and secondary healthcare services. They accounted for 38% of government funding to hospitals, 8.8% of OPD visits and 28% of admissions in Uganda in FY 2016/17. We assessed the levels, trends and determinants of technical efficiency of general hospitals in Uganda from FY 2012/13 to FY 2016/17.Methods We undertook input-oriented Data Envelopment Analysis to estimate technical efficiency of 78 general hospitals using data abstracted from the Annual Health Sector Performance Reports for FY 2012/13, 2014/15 and 2016/17. Trends in technical efficiency was analysed using Excel while determinants of technical efficiency were analysed using Tobit Regression Model in STATA 15.1.Results Average Constant Returns to Scale, Variable Returns to Scale and Scale Efficiency of general hospitals for FY 2016/17 were 49% (95% CI, 44% − 54%), 69% (95% CI, 65% − 74%) and 70% (95% CI, 65% − 75%) respectively. There was no statistically significant difference in the efficiency scores of public and private hospitals. Technical efficiency generally increased from FY2012/13 to 2014/15, and dropped by FY 2016/17. Some hospitals were persistently efficient while others were inefficient over this period. Hospital size, geographical location, training status and average length of stay were statistically significant determinants of efficiency at 5% level of significance.Conclusion The 69% average variable returns to scale technical efficiency indicates that the hospitals could generate the same volume of outputs using 31% (3,439) less staff and 31% (3,539) less beds. Benchmarking performance of the efficient hospitals would help to guide performance improvement in the inefficient ones. There is need to incorporate hospital size, geographical location, training status and average length of stay in the resource allocation formula and adopt annual hospital efficiency assessments.
The role of telehealth during COVID-19 outbreak: A systematic review based on current evidence
Authors: Monaghesh Elham , Hajizadeh Alireza
Published: May 2020

Purpose The outbreak of coronavirus disease-19 (COVID-19) is a public health emergency of international concern. Telehealth is effective option to fight COVID-19 outbreak. The aim of this systematic review was to identify the role of telehealth services during COVID-19 outbreak.Methods This systematic review was conducted through searching five databases including PubMed, Scopus, Embase, Web of Science and Science direct. Inclusion criteria included studies clearly defined role of telehealth services in COVID-19 outbreak, published from December 31, 2019, written in English language and published in peer reviewed. Two reviewers independently assessed search results, extracted data, and assessed quality of included studies. Quality assessment was based on the Critical Appraisal Skills Program (CASP) checklist. Narrative synthesis was undertaken to summarize and report the findings.Results Eight studies met the inclusion out of the 142 search results. Currently, healthcare providers and patients who are self-isolating, telehealth is certainly appropriate to minimizing the risk of COVID-19 transmission. This solution has the potential to avoidance of direct physical contact, provide continuous care to the community and finally reduce morbidity and mortality in COVID-19 outbreak.Conclusions The use of telehealth improves the provision of health services. Therefore, telehealth should be an important tool in caring services while keeping patients and health providers safe as the COVID-19 outbreak.