bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of River Valleys and the Upper Cretaceous Aquitard on Regional Flow in the Dakota Aquifer in the Central Great Plains of Kansas and Southeastern Colorado
Authors: Macfarlane P. Allen
Published: October 2021

In his reports on the regional hydrogeology of the central Great Plains, in particular southeastern Colorado and southwestern and central Kansas, Darton considered the Dakota aquifer to be a classic example of an artesian system. Computer simulations of the flow system in this study, however, suggest that the Dakota is not a regional artesian aquifer in the classic sense. Sensitivity analysis of a steady-state vertical profile flow model demonstrates that the flow system in the upper Dakota in western Kansas is heavily influenced by the Upper Cretaceous aquitard, the Arkansas River in southeastern Colorado, and rivers in central Kansas, such as the Saline, that have eroded through the aquitard and into the Dakota to the west of the main outcrop area of the aquifer. The model shows that local flow systems and the vertical hydraulic conductivity of the Upper Cretaceous aquitard heavily influence the water budget and the flow patterns. The aquitard restricts recharge from the overlying water table to underlying aquifers in western Kansas because of its considerable thickness and low vertical hydraulic conductivity. The Arkansas River intercepts ground-water flow moving toward western Kansas from recharge areas south of the river and further isolates the upper Dakota from sources of freshwater recharge. In central Kansas, the Saline River has reduced the distance between confined portions of the aquifer and its discharge area. In essence, this has improved the hydraulic connection between the confined aquifer and its discharge area, thus helping to generate subhydrostatic conditions in the upper Dakota upgradient of the river.
Heat Flow in the Cretaceous of Northwestern Kansas and Implications for Regional Hydrology
Authors: Forster Andrea , Merriam Daniel F.
Published: October 2021

Temperature logs are interpreted to investigate the thermal structure of the units overlying the Kansas portion of the Cretaceous Dakota aquifer. The aim of this study is to determine if additional heat input by fluids exists and thus clarify whether the overall conductive heat flow from the basement through the sequence might be overprinted by heat advection. Although interval thermal gradients are determined for different lithologic (stratigraphic) units, the shale thermal gradients are preferred for heat-flow estimation. Shale thermal conductivity as measured in Mesozoic shales in Nebraska and South Dakota is extrapolated to the area because of the similar lithology. A few thermal-conductivity values are determined in sandstone samples of the Dakota Formation and also used in heat-flow estimation. In general, the noncalcareous, marine Cretaceous shales (Pierre, Carlile, Graneros, and Kiowa) show different thermal gradients. Gradients in the Pierre (average value 58.5°C/km) and Carlile (55.5°C/km) are slightly higher than the average gradient in the Graneros Shale (45.1°C/km) and Kiowa Formation (46.5°C/km). The higher thermal gradients are limited to the extreme northwestern corner of the study area where the Pierre and Carlile are present. The heat-flow density of 69-74 mW/m2 observed there is slightly higher than the average of 60 mW/m2 typical for central and eastern Kansas. The higher heat flow observed is in the range of data reported and mapped for northeastern Colorado and the Nebraska Panhandle on the western flank of the Chadron Arch, an area with geothermal overprint by warm fluids. Regional differences in heat flow in western Kansas seemingly are caused by the different composition, porosity, and permeability of the aquifer and the nearness to recharge areas.
Allostratigraphic and Sedimentologic Applications of Trace Fossils to the Study of Incised Estuarine Valleys
Authors: Buatois Luis A. , Mangano Gabriela , Maples Christopher G. , Lanier William P.
Published: October 2021

The Tonganoxie Sandstone Member (Stranger Formation) records part of the infill of an estuarine valley system that was incised during a late Missourian (Late Carboniferous) drop in sea level and subsequently infilled during a transgressive episode later in the Virgilian (Late Carboniferous). At Buildex Quarry, in an eastern valley-margin position, this unit is represented by planar-bedded-and-laminated siltstone beds (tidal rhythmites) overlying a coplanar surface of lowstand erosion and subsequent transgression. These tidal rhythmites contain a relatively diverse ichnofauna dominated by arthropod trackways, surface grazing trails, fish traces, and tetrapod tracks, including the ichnogenera Circulichnis Vyalov, Dendroidichnites Demathieu, Gand, and Toutin-Morin, Diplichnites Dawson, Diplopodichnus Brady, Gordia Emmons, Helminthoidichnites Fitch, Helminthopsis Heer, Kouphichnium Nopcsa, Mirandaichnium Aceñolaza, Stiaria Smith, Stiallia Smith, Tonganoxichnus Mángano, Buatois, Maples, and Lanier, Treptichnus Miller, and Undichna Anderson. The Buildex ichnofauna represents a mixture of the nonmarine Scoyenia and Mermia ichnofacies and records the activity of a terrestrial and freshwater biota. Ichnologic evidence, coupled with sedimentologic data, suggests that the Buildex succession was deposited on tidal flats in the most proximal zone of the inner estuary, between the landward limit of tidal currents and the salinity limit further towards the sea. This type of trace-fossil assemblage seems to characterize the lower part of transgressive system tracts, immediately overlying the coplanar surface during the late Paleozoic. As transgression proceeded, tide-influenced freshwater facies tended to be replaced by retrogradational brackish-water parasequences, and the mixed Scoyenia and Mermia ichnofacies was replaced by a Skolithos-impoverished Cruziana ichnofacies. The coplanar surface (flooding surface and sequence boundary) that marks the base of the Tonganoxie sequence at Buildex lacks the substrate-controlled, marine Glossifungites ichnofacies. The coals and paleosols with upright plant remains that typify the coplanar surface at Buildex represent erosional truncation and subsequent omission close to the interfluves and may be regarded as the landward equivalent of the Glossifungites ichnofacies. Buildex-type ichnofaunas probably are widespread in Pennsylvanian tidal rhythmites of the U.S. Midcontinent and may be used to identify freshwater inner estuarine facies, to delineate fluvio-estuarine transitions in incised valley systems, and to refine models based exclusively on lithofacies evidence.
The Geology of Kansas—Arbuckle Group
Authors: Franseen Evan K. , Byrnes Alan P. , Cansler Jason R. , Steinhauff D. Mark , Carr Timothy R.
Published: October 2021

Cambrian-Ordovician Arbuckle Group rocks in Kansas occur entirely in the subsurface. As is demonstrated throughout this paper, the historical and current understanding of the Arbuckle Group rocks in Kansas has in large part been dependent on petroleum-industry philosophies, practices, and trends. The widely accepted conceptual model of Arbuckle reservoirs as an unconformity play guided drilling and completion practices in which wells were drilled into the top of the Arbuckle with relatively short penetration (under 10 to 50 ft) deeper into the Arbuckle. This resulted in very little log or core data available from the Arbuckle interval. In addition, due to the early development (1917-1940) of the majority of Arbuckle reservoirs, log and geophysical data are not up to modern standards. Over the last few decades, deep penetrating wells have been drilled into the Arbuckle accompanied by full modern log suites and drill-stem tests. However, little corresponding core has been taken to calibrate the logs, and no detailed studies have been conducted to date on the more extensive, modern log data. Thus, data and detailed understanding of Arbuckle Group strata in Kansas are lacking relative to Arbuckle and age-equivalent strata from other areas in the United States, especially those where Arbuckle strata crop out. However, Arbuckle Group strata remain an important reservoir target in Kansas, and our understanding of the unit will increase with continued studies that incorporate modern data, techniques, and approaches.
Temporal Variability in the Quality of Produced Water from Wells Tapping the Ozark Aquifer of Southeast Kansas
Authors: Macfarlane P. Allen
Published: October 2021

State and local agencies have become concerned that the available water supply from the Ozark aquifer in the Tri-state region of southeast Kansas, southwest Missouri, and northeastern Oklahoma may become unusable or require additional water treatment because of deteriorating quality resulting from overdevelopment. Many southwest Missouri and southeast Kansas water supplies withdraw water from a 30-60-mi (48-96-km)-wide transition zone in the Ozark aquifer that separates calcium, magnesium-bicarbonate ground water with low dissolved solids to the east from sodium-chloride brines to the west. Water-quality deterioration within the transition zone could potentially come about as a result of eastward migration or upward movement from deeper horizons of saline water. This study assessed variability in the quality of water produced from wells within the transition zone in southeast Kansas across a variety of time scales. Water samples were collected monthly from nine wells located in the transition zone over a two-year period and frequently during two 50+ hr chemical-quality pumping tests of Pittsburg well 8. The samples were analyzed for conductance and pH, and all major and selected minor dissolved inorganic constituents. Mixing curves of chloride versus bicarbonate/chloride ratio and chloride versus sodium/chloride ratio demonstrate that the produced water from Ozark aquifer wells is a mixture of low dissolved solids, calcium, magnesium-bicarbonate ground waters and sodium-chloride brines. Produced water from wells tapping sources in the Ozark and the overlying Springfield Plateau aquifers is a blend of waters from these sources, although the data suggest that the contribution from the Springfield is small relative to the Ozark aquifer. Fluctuations in the quality of the produced water during pumping most likely result from complex mixing of waters of differing quality from different parts of the Ozark aquifer within the well bore. This is borne out by bicarbonate/chloride ratio versus chloride concentration mixing curves and the dissolved constituent ratios indicative of bicarbonate and sodium in excess of that required to balance calcium + magnesium and chloride, respectively. Comparison of the 1979-1980 data with the 2006-08 data from this project indicates that the chloride concentration in some of the sampled supplies has increased. Based on extrapolation of the maximum estimated rate of chloride concentration increase, the earliest that water from Pittsburg wells 8 and 10 would exceed the recommended drinking water limit for chloride is estimated to be by the years 2045 and 2060, respectively, assuming continuation of the present rates of pumping.
Polymerase chain reaction (PCR) v5
Authors: Guo Shuning
Published: October 2021

This protocol is used to amplify target DNA fragment for plasmid construction or other use.
Rapport in the Foreign Language Classroom: From Face-to-Face to Online in Times of Pandemic
Authors: Katz Shayna
Published: October 2021

As shown in previous studies, positive teacher and student rapport increases motivation and performance in foreign language learning. This study investigated the impact of three forms of interaction on the development of teacher-student and student-student relationships in a Spanish as a Foreign Language classroom that transitioned from face-to-face (FtoF) to online due to the emergence of the covid- 19 pandemic. These forms of interaction were positive comments, corrective feedback, and personal thematic discourse. The participants were students from six different beginner-level Spanish courses at a university in Hawai’i. Because of covid restrictions, half of the semester was conducted FtoF and half online. Data were collected through a three-part questionnaire with open and closed-ended questions which explored the impact of the online and FtoF setting and forms of interaction on rapport. The results reveal the importance of corrective feedback and positive comments on the development of positive teacher-student rapport, and of positive comments and personal thematic discourse on student-student rapport. The study suggests the need to bring qualities from the FtoF classroom to online, such as a sense of a more personal experience, ability to connect, ease in asking questions, receiving feedback, and greater interaction.
Dual Immersion Digital Instruction: A Theoretical Model for Equitable and Inclusive Classrooms
Authors: Solsona-Puig Jordi , Capdevila-Gutiérrez María , Rodríguez-Valls Fernando
Published: October 2021

Dual immersion programs have proven effective in achieving biliteracy for all students. However, maintaining equitable practices at the core of such programs has become more challenging in remote learning due to the pandemic. It is necessary, therefore, to revise some of the benefits and challenges of digital instruction mediated by technology in these settings. Using a middle school Dual Immersion (di) program in Southern California as a background, and from the perspective of bilingual education teachers and professors, this article presents a theoretical model called Dual Immersion Digital Instruction (di2) that could serve that purpose. The model includes the five dimensions involved in just, equitable, and inclusive education: Technological, content, social, linguistic, and pedagogical. The article also analyzes the pedagogical opportunities and challenges that teachers in di programs face in regards to each of these dimensions when all instruction becomes fully online. Finally, the article discusses how the shift to online teaching in di classrooms could impact bilingual teacher education programs.
SUFFICIENT CONDITION FOR COINCIDENCE OF THE LS AND AITKEN ESTIMATIONS OF PARAMETER OF QUADRATIC REGRESSION IN CASE HETEROSCEDASTIC DEVIATIONS
Authors: Savkina Marta
Published: October 2021

In the paper in case heteroscedastic independent deviations a regression model whose function has the form $f(x) = ax^2+bx+c$, where $a$, $b$ and $c$ are unknown parameters, is studied. Approximate values (observations) of functions $f(x)$ are registered at equidistant points of a line segment. The theorem which is proved at the paper gives a sufficient condition on the variance of the deviations at which the Aitken estimation of parameter $a$ coincides with its estimation of the LS in the case of odd number of observation points and bisymmetric covariance matrix. Under this condition, the Aitken and
LS estimations of $b$ and $c$ will not coincide. The proof of the theorem consists of the following steps. First, the original system of polynomials is simplified: we get the system polynomials of the second degree. The variables of both systems are unknown variances of deviations, each of the solutions of the original system gives a set variances of deviations at which the estimations of Aitken and LS parameter a coincide. In the next step the solving of the original system polynomials is reduced to solving an equation with three unknowns, and all other unknowns are expressed in some way through these three. At last it is proved that there are positive unequal values of these three unknowns, which will be the solution of the obtained equation. And all other unknowns when substituting in their expression these values will be positive.
Regulation of the functional activity of peripheral B lymphocytes in pregnant women with a history of recurrent miscarriage
Authors: Malyshkina Anna I. , Sotnikova Natalia Y. , Voronin Dmitriy N. , Kust Alena V.
Published: October 2021

BACKGROUND:The frequency of recurrent miscarriage is up to 5 % of all desired pregnancies and is mainly due to immunological disorders. Dysfunction in the regulation of the functional activity of B lymphocytes is the pathogenetic link in multiple obstetric complications, including habitual miscarriage.
AIM:The aim of this study was to characterize the regulation of the functional activity of peripheral B lymphocytes in pregnant women with threatened spontaneous miscarriage and a history of habitual miscarriage.
MATERIALS AND METHODS:We examined 88 women aged 18-40 years at a gestation period of 5-12 weeks. The main group consisted of 36 patients with threatened spontaneous miscarriage at the time of examination and a history of habitual miscarriage. The control group included 28 women with uncomplicated pregnancy. The comparison group consisted of 24 primary pregnant patients with threatened spontaneous abortion at the time of examination. BAFF and APRIL levels in the blood serum were determined by enzyme immunoassay. The content of CD19+BAFFR+B lymphocytes in the lymphocyte gate was evaluated in the peripheral blood by flow cytometry using monoclonal antibodies. Akt mRNA expression was assessed using real-time reverse-transcription quantitative polymerase chain reaction. CD19+В lymphocytes were isolated by direct magnetic separation.
RESULTS:In the main group, there was an increase in expression of BAFF receptors on peripheral CD19+B lymphocytes and a decrease in the serum BAFF concentration compared to the parameters in the other study groups. We also found a pronounced trend towards a decrease in the serum APRIL level in the main and comparison groups of patients compared to healthy pregnant women. Besides, Akt mRNA expression in peripheral CD19+B lymphocytes was increased in the main group.
CONCLUSIONS:Threatened habitual abortion is associated with the deficit of the regulatory influence of BAFF and APRIL, which is expressed in the disruption of B cell homeostasis and the weakening of humoral effector mechanisms.
Assessment of 25(OH)D status in patients with genital endometriosis and clinical efficacy of cholecalciferol in the treatment of the disease
Authors: Denisova Alexandra S. , Yarmolinskaya Maria I. , Tkachenko Natalia N.
Published: October 2021

AIM: The aim of this study was to determine the 25(OH)D status in patients with genital endometriosis compared to the control group and to analyze the clinical efficacy of cholecalciferol implication as a combined targeted therapy of the disease.
MATERIALS AND METHODS: The main group included 440 patients with genital endometriosis (mean age 33.75.8 years) with various degrees of disease prevalence. The control group consisted of 30 women with the normal ovulatory menstrual cycle (mean age 26.33.1 years) in whom gynecological pathology was not revealed. Peripheral blood (PB) 25(OH)D level was assessed in all the participants included into the study. In 49 women from the main group, the level of 25(OH)D in the peritoneal fluid (PF) was determined. Comparative evaluation of the clinical efficacy of cholecalciferol intake in combination with gonadotropin-releasing hormone agonist (aGnRH) 3.75 mg injections or with dienogest 2 mg oral administration, as well as monotherapy in comparison with standard hormone-modulating treatment was carried out. Prior to the start of treatment, the patients had pain syndrome of varying severity, which was evaluated using the McGill Pain Questionnaire with the Visual Analogue Scale for pain. The psycho-emotional status was assessed using the Hospital Anxiety and Depression Scale. The Excel, Statistica 10, and Jamovi software programs were used to process the obtained data.
RESULTS: The level of 25(OH)D in PB of patients with endometriosis was significantly lower compared to the control group (p 0.001). Women with Grades III and IV genital endometriosis were characterized by lower PB 25(OH)D levels compared to the patients with Grades I and II of the disease, but the difference was not statistically significant. Relationships were revealed between 25(OH)D levels in the PB and PF (p 0.001), as well as PF 25(OH)D level and the disease prevalence (p = 0.004). Significantly more pronounced pain reduction and stabilization of the psycho-emotional status were observed in patients receiving combined therapy with cholecalciferol.
CONCLUSIONS: Insufficient level of vitamin D and vitamin D deficiency can be considered as factors that play a role in the progression of genital endometriosis. The use of cholecalciferol in combination with aGnRH 3.75 mg or dienogest 2 mg may more effectively reduce the severity of pain and stabilize the psycho-emotional status in patients with genital endometriosis compared to standard hormone-modulating therapy.
Evaluation of sFlt-1 and PlGF for predicting preeclampsia in pregnant women with diabetes mellitus
Authors: Kapustin Roman V. , Tcybuk Elizaveta M. , Chepanov Sergey V. , Alekseenkova Elena N. , Kopteeva Ekaterina V. , Arzhanova Olga N.
Published: October 2021

AIM: The aim of this study was to evaluate soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) levels in the blood of women with various types of diabetes mellitus, depending on the correction method applied, and to determine the prognostic significance of the sFlt-1 / PlGF ratio for predicting the development of preeclampsia in this patient population.
MATERIALS AND METHODS: We examined 140 pregnant women who were included in six main study groups: type 1 diabetes mellitus (with or without pregravid preparation), type 2 diabetes mellitus (diet therapy or insulin therapy), and gestational diabetes mellitus (diet therapy or insulin therapy). The comparison groups consisted of pregnant women with preeclampsia and patients without complications of pregnancy. Using electrochemiluminescence analysis, PlGF and sFlt-1 levels in the blood serum were determined twice, at 11+013+6 and 30+033+6 weeks of gestation. Statistical data processing was performed using the IBM SPSS Statistics version 23 and GraphPad Prism version 8.0 software packages.
RESULTS: In the blood serum of pregnant women with diabetes mellitus in the first and third trimesters of pregnancy, we found an increase in sFlt-1 level and a decrease in PlGF level, as well as an increase in the sFlt-1 / PlGF ratio. These changes were most pronounced in individuals with type 1 diabetes mellitus without pregravid preparation and with type 2 diabetes mellitus on insulin therapy. In patients with pregestational types of diabetes mellitus, the sFlt-1 / PlGF ratio was a predictor of preeclampsia already in the early stages of pregnancy. Analysis of the ROC curve showed that the threshold sFlt-1 / PlGF ratio for predicting preeclampsia in pregnant women with diabetes mellitus in the first trimester was 32.5 (sensitivity 92.9%, specificity 50.0%) and in the third trimester 71.8 (sensitivity 85.7%, specificity 82.3%) with AUC 0.78 (95% CI 0.680.88) and 0.89 (95% CI 0.830.95), respectively. In the first trimester, the positive and negative predictive values of the sFlt-1 / PlGF ratio as a predictor of preeclampsia in pregnant women with diabetes mellitus were 63.3% and 97.6%, respectively; in the third trimester, 38.9% and 93.6%, respectively.
CONCLUSIONS: Blood level alterations of PlGF and sFlt-1 are characteristic of patients with diabetes mellitus in the first and third trimesters of pregnancy. An increase in the sFlt-1 / PlGF ratio is associated with a higher incidence of unfavorable perinatal outcomes in women with impaired carbohydrate metabolism. Determination of the sFlt-1 / PlGF ratio is a valid method for predicting the development or absence of preeclampsia in women with diabetes mellitus.
The value of vaginal lactobacilli in the restoration of vaginal microbiocenosis in women in the early postpartum period, depending on the method of delivery
Authors: Dadayeva Dzhamilya G. , Budilovskaya Olga V. , Krysanova Anna A. , Khusnutdinova Tatyana A. , Savicheva Alevtina M. , Kogan Igor Y.
Published: October 2021

BACKGROUND: Despite numerous studies of the vaginal microbiota, there is still a lack of knowledge regarding its restoring dynamics in the early postpartum period. The condition of the vaginal microflora during pregnancy plays a key role in maintaining the physiological microbiocenosis of the birth canal and creating conditions for the normal course of pregnancy, the establishment of an infants intestinal microbiota, and the further development of the child.
AIM: The aim of this study was to estimate the role of certain types of lactobacilli in restoring the vaginal microbiota in women in the early postpartum period, depending on the method of delivery.
MATERIALS AND METHODS: We examined 150 women at 38-41 weeks of gestation. The clinical material for the study was vaginal discharge before and after delivery. To determine the species of lactobacilli and other microorganisms in the clinical material, we used quantitative real-time PCR.
RESULTS: Before delivery, lactobacilli were found in vaginal discharge in 144 out of 150 women (96.0%), their number in the majority being more than 106 GE. In the postpartum period, lactobacilli were found in 66/128 (51.5%) cases, while prevailing in women after vaginal delivery in 50/65 (76.9%) cases (4.61.6, p = 0.000000). Among the dominant species of lactobacilli was L. crispatus, found in vaginal discharge before delivery, which most often affects the recovery of the vaginal microbiota in the postpartum period (29 out of 61 women, 47.5%). L. iners detected in the lochia predisposes to the violation of uterine involution in the early postpartum period (p = 0.03).
CONCLUSIONS: Normal vaginal microbiota in the postpartum period is restored more quickly in women after vaginal delivery. Our study confirms that L. crispatus and L. iners play a major role in restoring the vaginal microbiota in the postpartum period.
Ankara’da Görüntü Kirliliği: Reklam Tabelaları Üzerine Bir Analiz
Authors: TOROS Seçil
Published: October 2021

Birçok şehirde açıkhava reklamları hızla yaygınlaşırken, otoyollara ve sokaklara yerleştirilen reklam panoları
şehirlerin peyzajına hâkim hale gelmekte, bina cepheleri reklam iskelesine dönüşmektedir. Bu bağlamda
kamusal alanlara yayılan reklamların, şehrin mimari dokusunu ve çevre görüntüsünü bozarak, görüntü
kirliliğine yol açtığı iddiası literatürde daha sıklıkla dile getirilmektedir. Bu çalışmada bahsi geçen iddiaları
test etmek amacıyla bina cepheleri incelenerek, reklam tabelalarının bina cephelerini ne oranda kapladığı
araştırılmıştır. Bu amaçla çalışma için örnek olarak seçilen Ankara Aşkabat Caddesi boyunca tüm bina
cepheleri içerik analizi yöntemi ile incelenmiştir. Yapılan analizlerde reklam tabelalarının bina cephelerinin
ortalama olarak üçte birini kapladığı ve bu oranın bazı binalar için yüzde 74’e kadar çıktığı saptanmıştır.
Görüntü kirliliği için kabul görmüş belli bir doygunluk sınırı ya da eşik bulunmamakla birlikte, bu oranı
dikkate alarak reklam tabelalarının caddede görsel kirlilik yarattığı söylenebilir. Bu çalışma kontrolsüz
tabela kullanımı ile oluşan görüntü kirliliği konusunda somut kanıtlar ortaya koymakla beraber konunun
ölçümü için niceliksel bir yöntem önererek alana katkı yapmayı amaçlamaktadır.
Increased Fungal Infections while using Emerging
Therapies (Biologics and Small-molecule Inhibitors)
for Treating Skin Diseases: A Review
Authors: Kim Jung Eun , Lee Kyung Jae
Published: October 2021

Biologics, such as tumor necrosis factor-α and interleukin inhibitors, are commonly used for treating immunological skin diseases, including psoriasis, psoriatic arthritis, and atopic dermatitis. The cluster of differentiation inhibitors and immune checkpoint inhibitors has also been used for treating bullous disorders and melanoma, respectively. Other small-molecule inhibitors, such as JAK inhibitors, have been introduced for treating atopic dermatitis and alopecia areata. Hence, given the importance of cytokines and small molecules in antifungal immunity, using these new treatments are proposed to increase the risk of fungal infections. Thus, this review presents an overview of the reported incidences and possible mechanisms of fungal infections related to the use of biologics, including small-molecule inhibitors used for dermatological treatments.
TEKNOLOGI INFORMASI, PERILAKU INOVATIF, KOMPETENSI, KEPUASAN KERJA, DAN KINERJA MANAJEMEN PENDIDIKAN 4.0
Authors: Sukadana Komang , Mahyuni Luh Putu
Published: October 2021

Abstract: Industrial revolution 4.0 drives significant transformation to all sectors, including the education sector. Head of school plays significant roles in transforming the education to adapt to the changes. Therefore, it is very important to understand factors explaining head of school performance in leading the school through industrial revolution 4.0. This study aims at empirically testing the relationships between information technology, inovative attitude, competency, work satisfaction, and performance of head of school. Quantitative approach was used to answer research questions. As many as 110 questionnaires were collected and analyzed by using Structural Equation Modeling. This study indicates that informaton technology, innovative attitude, competency, significantly influence work satisfaction and performance of head of school. Keywords: Information technology; innovative attitude; competency; work satisfaction; performance; head of school; education 4.0 Abstrak: Revolusi industri 4.0 mendorong terjadinya perubahan signifikan pada berbagai sektor, termasuk pendidikan. Kepala sekolah merupakan ujung tombak manajemen pendidikan 4.0, sangat penting memahami faktor yang mempengaruhi kinerja mereka. Penelitian ini bertujuan untuk menguji bagaimana teknologi informasi, perilaku inovatif, kompetensi, dan kepuasan kerja mempengaruhi kinerja kepala sekolah. Untuk mencapai tujuan penelitian, digunakan pendekatan kuantitatif melalui penyebaran kuesioner kepada 110 kepala sekolah. Data dianalisis dengan Structural Equation Modelling (SEM). Penelitian ini mengindikasikan bahwa teknologi informasi, perilaku inovatif dan kompetensi memiliki dampak yang positif signifikan terhadap kepuasan kerja dan kinerja kepala sekolah. Kontribusi penelitian ini bagi literatur adalah memperkuat teori bahwa kompetensi, teknologi informasi dan perilaku inovatif berpengaruh terhadap kepuasan dan kinerja kepala sekolah. Kata kunci: Teknologi informasi; perilaku inovatif; kompetensi; kepuasan kerja; kinerja, kepala sekolah; pendidikan 4.0
EVALUASI KUALITAS JASA SEKOLAH DASAR DENGAN MODEL SERVQUAL UNTUK MENANGANI PENURUNAN JUMLAH PESERTA DIDIK
Authors: Jonathan Gloria , Iriani Ade
Published: October 2021

Abstract: This study aims to evaluate the service quality of Kanaan Christian Elementary School in Banjarmasin. Type of research is evaluative research with descriptive qualitative methods using SERVQUAL model which measures the gap between consumer perceptions and expectations based on dimensions of reliability, responsiveness, assurance, empathy, and tangibility. Data were collected by interview, also using a SERVQUAL and school’s input, process and output aspect questionnaire. The results showed that the perception of service from customers is quite good and able to meet the minimum expectations although it has not reached the desired expectations. The order of SERVQUAL's five dimensions from most satisfying to least satisfying is: tangibility, reliability, empathy, assurance, and responsiveness. It can be concluded that the dimension of responsiveness is in the most unsatisfactory position because currently the management of Kanaan Christian Elementary School in Banjarmasin seems like there is no one taking a leader role. Things that can be considered by Kanaan Christian Elementary School are to keep and prove the promise that has been delivered so that customers are not easily disappointed and also involve parents in a word of mouth marketing strategy due to the character of target customers are critical, like to gather and chat together. Keywords: educational service; school quality; SERVQUAL Abstrak: Penelitian ini bertujuan mengevaluasi kualitas jasa di SD Kristen Kanaan Banjarmasin. Jenis penelitian ini adalah penelitian evaluatif dengan metode kualitatif deskriptif menggunakan model SERVQUAL yang mengukur kesenjangan antara persepsi dan ekspektasi konsumen berdasarkan dimensi reliabilitas, daya tanggap, jaminan, empati, dan bukti fisik. Teknik pengumpulan data dengan wawancara, dibantu kuesioner berinstrumen SERVQUAL dan aspek input, proses dan output sekolah. Hasil menunjukkan bahwa persepsi layanan jasa dari pelanggan cukup baik dan cukup memenuhi harapan minimum walaupun belum mencapai harapan yang diinginkan. Urutan lima dimensi SERVQUAL dari yang paling memuaskan hingga yang paling tidak memuaskan adalah: bukti fisik, keandalan, empati, jaminan, dan daya tanggap. Disimpulkan dimensi daya tanggap berada di posisi paling tidak memuaskan adalah karena saat ini manajemen SD Kristen Kanaan Banjarmasin seolah seperti tidak ada yang mengambil peran pemimpin. Hal yang dapat menjadi pertimbangan SD Kristen Kanaan adalah agar dapat menjaga dan membuktikan janji yang telah disampaikan agar pelanggan tidak mudah kecewa dan dapat melibatkan orang tua murid dalam strategi pemasaran mulut ke mulut mengingat karakter target pelanggan yang kritis, suka berkumpul dan mengobrol. Kata kunci: jasa pendidikan; kualitas sekolah; SERVQUAL
Conditions and Opportunities for Overcoming the Economic Crisis
Authors: Komkov N. I.
Published: October 2021

Purpose: the purpose of the presented article is to study the conditions and possibilities of overcoming the protracted economic crisis in Russia.

Methods: the study is based on the use of a modified information logic model, which establishes the relationships between the identified bottlenecks, the causes of their occurrence and possible ways to eliminate these causes.

Results: the possibilities of overcoming the crisis are, first of all, to use the potential accumulated in the Russian economy, dispersed by sectors of the complete technological reproduction cycle, including the extraction of resources, their processing into useful materials and semi-finished products, the production of machinery and equipment, as well as the production of final products, the provision of services, infrastructure and waste disposal. Simultaneously with the search for opportunities for economic growth, it is necessary to draw the attention of the Russian Government and the legislative and executive heads to the necessity to correct the strategic mistakes. They were conducted in the process of choosing a resource-export development strategy, separating the financial sector from the support and interests of the development of domestic industrial production sector, ignoring the potential and opportunities for the development of the domestic scientific and technological complex, using imperfect economic management mechanisms, etc. The work justifies the need to overcome a long economic crisis via the management of new opportunities breakthrough, which involves the harmonious development of all economic sectors based on supporting a domestic scientific and technical complex capable to ensure the high technologies development and the competitive products production.

Conclusions and Relevance: substantiating and choosing ways to overcome the economic crisis should be focused on achieving harmonious development of all sectors of the economy and using in management practices at the national, corporate and company levels, such methods and instruments of targeted projects and programs management, which are the core basis for economy and society development strategies.
Measuring the Sciences Contribution to Socioeconomic Development: Russian Approaches in the Global Space of Ideas
Authors: Yanik A. A.
Published: October 2021

Purpose: this review aims to present the ‘state-of-the-art’ on the theory and practice of measuring the contribution of sciences to socioeconomic progress and trace the Russian approaches in the global space of ideas.

Methods: for studying a multidisciplinary sample of academic publications and gray literature includes multifactor systematization, critical analysis, and synthetic generalization in a large context («helicopter view»).

Results: a brief history of the subject is presented in the context of the state's use of science for socio-economic development. The review outlines the focus areas of scientific thought, the conceptual frameworks state, current approaches to measuring the contribution of sciences, the limitations and risks of the evaluation practice.

Conclusions and Relevance: key areas of scientific thought in the subject under review for 100 years: (1) development of econometric approaches for measuring the «profitability» of science; (2) attempts to identify and measure the societal impacts of science; (3) scientific support of government experiments to use the evaluation technologies for increasing the return of budget investment to science; (4) conceptualizing and universalizing the terms. There are no indisputable solutions in any of these areas. Disappointment with the catch-all indicators and universal metrics encourages the development of case-oriented methods and process-oriented approaches.

Russian research covers the full range of issues, but their world recognition (except some achievements of Soviet time) is low. The lack of institutional memory leads to the rediscovery of the ideas of the 20th century. Establishing the equivalence of terms and conceptual approaches used by scientists from different countries and periods will help to effectively use the scientific heritage, avoid duplicate research, provide a fair place to the Russian achievements in world science.
Dual-Class System of Capital Company Formation in the BRICS Countries
Authors: Voskanian R. O.
Published: October 2021

Purpose: this paper determinates the current level of penetration of the dual-class system of capital company formation in the BRICS group.

Methods: are based on the use of methods of analysis, systematization, generalization. A comparative and synthesis methods have been also used to identify trends and patterns in the introduction of multi-voting shares in the BRICS group.

Results: the dual-class system of capital company formation in Russia is practically not studied. The article reveals that in Brazil and Russia, despite the discussion of the possibility of distributing multi-voting shares, the legislation does not imply the possibility of using the dual-class system. This issue has not yet been discussed in South Africa.

It has been identified that the main reason for the legislative permission for using multi-voting shares is the need to develop companies in the high-tech sector. Another reason is the massive listing of foreign high-tech companies on American stock exchanges, due to the possibility of using the dual-class system. This predetermined the introduction of amendments to the legislation of India and China, according to which companies in the high-tech sector that have not yet passed an IPO can use differential voting rights.

It has been receiving that the Indian market is the only one where shares with differentiated voting rights are placed on the stock exchange. At the moment, three companies that passed the IPO before the amendments to the legislation use differentiated voting rights, but not upwards, but on the contrary – downwards: “four shares – three votes”. This characteristic determines the trading of such stocks at a discount.

Conclusions and Relevance: harmonization of opportunities for the use of financial instruments in the BRICS market can strengthen the economic potential of states. Allowing the usage of multi-voting shares improves the business environment for high-tech companies and reduces the need for company founders to look for IPO opportunities in jurisdictions where a dual-class capital formation system is allowed.
The Concept of Sustainable Mobility in Modern Megacities
Authors: Zavyalov D. V.
Published: October 2021

Purpose: to formulate the general conception of sustainable mobility management in modern cities based on an analysis of the main approaches to the management of the development of sustainable mobility.

Methods: the study is based on the application of systems analysis methods. The analysis is based on open sources information such as scientific articles, legal and regulatory acts, official strategic planning documents, analytical and methodical materials of Russian and international conferences. The article also includes the results of the author's empirical research conducted.

Results: an analysis of the development of sustainable transport mobility in large cities and current strategies for its further formation was carried out. It allowed identifying the main elements of the conceptual model of the development of transport mobility. The research defines the structure of an adaptive system for sustainable mobility management, which would form a basis for developing a sustainable mobility concept to effectively organize various stakeholders' cooperation.

Conclusions and Relevance: local solutions for transportation mobility may not be practical or can lead to a conflict of interests. That calls for the complex approach to forming sustainable mobility as a feature of a city transportation system to satisfy the demand for mobility to increase the quality of life in the cities. The conceptual basis for the development of sustainable mobility consists of goal setting, planning, collaboration, implementation, usage.

The effective management of sustainable mobility can be achieved by implementing digital analytical platforms, working as a single ecosystem. Developing such an ecosystem can be time-consuming and directly influenced by technological, infrastructural, legal, and economic factors. The most urgent is to redesign the existing mobility patterns to achieve the environmental goals, the higher quality of life of city residents, the engagement of different stakeholders in sustainable mobility development.
Nonparametric pattern recognition algorithm for testing a hypothesis of the independence of random variables
Authors:   Siberian Federal University, Zenkov I.V. ,   Reshetnev Siberian State University of Science and Technology, Lapko A.V. ,   Institute of Computational Modelling SB RAS,   Reshetnev Siberian State University of Science and Technology, Lapko V.A. ,   Institute of Computational Modelling SB RAS,   Reshetnev Siberian State University of Science and Technology, Kiryushina E.V. ,   Siberian Federal University, Vokin V.N. ,   Siberian Federal University
Published: October 2021

A new method for testing a hypothesis of the independence of multidimensional random variables is proposed. The technique under consideration is based on the use of a nonparametric pattern recognition algorithm that meets a maximum likelihood criterion. In contrast to the traditional formulation of the pattern recognition problem, there is no a priori training sample. The initial information is represented by statistical data, which are made up of the values of a multivariate random variable. The distribution laws of random variables in the classes are estimated according to the initial statistical data for the conditions of their dependence and independence. When selecting optimal bandwidths for nonparametric kernel-type probability density estimates, the minimum standard deviation is used as a criterion. Estimates of the probability of pattern recognition error in the classes are calculated. Based on the minimum value of the estimates of the probabilities of pattern recognition errors, a decision is made on the independence or dependence of the random variables. The technique developed is used in the spectral analysis of remote sensing data.
Women in IT-ITES Industries: Their Coping Styles and Quality of Work Life
Authors: Bharathi . , Kavya .
Published: October 2021

Women have chosen to establish their names in the competitive globe along with being good home-makers. Information Technology-Information Technology Enabled Services (IT-ITES) industries have helped women to establish their names in the competitive globe along with being good home-makers. With increasing responsibilities, women have been subjected to increasing stress. Women tend to use different coping styles to protect themselves against stress. Not all coping mechanisms are healthy. Meanwhile attention needs to be paid on the quality of their work life, as it’s a very competitive and dynamic industry. This study emphasizes on the different coping styles adopted by the women employees, their quality of work life and the relationship between these two variables. The research design used for the study is descriptive design. The researcher adopted convenient sampling technique to collect data from 307 women employees representing six IT-ITES companies in Bangalore city. The study revealed that the ‘distractive positive’ method of coping style was the most widely used by the women employees. The ‘quality of work life’ of these women employees was on the higher side. The results also showed that there is a significant relationship between coping style and quality of work life.
Comparison of Mammography and Ultrasonography in the Diagnosis of Breast Lesions with Fine Needle Aspiration Cytology – A Cross Sectional Study in East Godavari District, Andhra Pradesh
Authors: D. Sowmya , S Anusha , L.V.S.S.N. Prasanna Pidaparti , T. Jaya Chandra , V. Mythri Priyadarshini
Published: October 2021

BACKGROUND Breast cancer is the second most common malignancy and most common among women next to lung cancer. A small lump in the breast leads to great physical, emotional, and psychological trauma to the victim and as well as family. In addition to clinical examination, imaging modalities like mammography (MG), ultrasonography (USG), cytological diagnosis by fine needle aspiration cytology (FNAC) and tissue diagnosis were used for the diagnosis. These diagnostic techniques have certain pitfalls in addition to their advantages. A study was conducted to evaluate the breast lesions according to breast imaging reporting and data system using MG and USG, correlation with FNAC. METHODS It was a cross-sectional study, conducted in the Department of Radio-diagnosis, GSL Medical College, Rajahmundry from January 2018 to June 2019, over a period of 18 months. An informed consent was taken from all the participants. The individual with palpable breast lesions detected in clinical examination were included. Physiological swelling, ulcerated and fungal breast growths were not considered. After the detailed clinical history, physical examination, MG and USG were performed, proceeded for FNAC, smears were stained with Leishman and Papanicolaou stain. Statistical analysis was performed by Statistical Package for Social Sciences (SPSS version 20.0). Descriptive data was presented in the form of mean, standard deviation and percentages. Chi-square test was done to assess the association among various categorical data, P < 0.05 was considered statistically significant. RESULTS Total 142 participants were included, maximum number belong to 41 to 50 years, 0.7 % were male. Right side lesion was the predominant. With FNAC, the sensitivity, specificity and the diagnostic accuracy were 86.5 %, 97.8 % and 93.7 %, respectively for benign breast lesions (BBL) diagnosis and 96.7 %, 84.6 %, 92.25 % respectively for malignant breast lesions (MBL) diagnosis. CONCLUSIONS The sensitivity, specificity and diagnostic accuracy was observed to be higher in diagnosis of both BBL and MBL with the combined modalities. KEYWORDS Breast Lesions, Benign, Malignant
Конституционно-правовые аспекты реализации права на охрану здоровья и медицинскую помощь в России в условиях распространения новой коронавирусной инфекции COVID-19
Authors: Тимошенкова Т.В. , Тимошенкова А.А.
Published: October 2021

В статье анализируются конституционно-правовые аспекты реализации права на охрану здоровья и медицинскую помощь в России в условиях вызовов, связанных с распространением новой коронавирусной инфекции COVID-19; проводится правовой анализ мер по борьбе с распространением вируса COVID-19, которые принимаются на федеральном и региональном уровнях, на предмет их адекватности, соразмерности и соответствия положениям Конституции РФ и действующему законодательству; анализируются особенности реализация права на качественную и доступную медицинскую помощь в условиях необходимости быстрой диагностики и оказания помощи больным COVID-19.