bluuebunny/crossref_metadata_2025 huggingface dataset:
Co‐expression of diurnal and ultradian rhythms in the plasma metabolome of common voles (Microtus arvalis)
Authors: Psomas Andreas , Chowdhury Namrata R. , Middleton Benita , Winsky‐Sommerer Raphaelle , Skene Debra J. , Gerkema Menno P. , van der Veen Daan R.
Published: March 2023

Metabolic rhythms include rapid, ultradian (hourly) dynamics, but it remains unclear what their relationship to circadian metabolic rhythms is, and what role meal timing plays in coordinating these ultradian rhythms in metabolism. Here, we characterized widespread ultradian rhythms under ad libitum feeding conditions in the plasma metabolome of the vole, the gold standard animal model for behavioral ultradian rhythms, naturally expressing ~2‐h foraging rhythms throughout the day and night. These ultradian metabolite rhythms co‐expressed with diurnal 24‐h rhythms in the same metabolites and did not align with food intake patterns. Specifically, under light–dark entrained conditions we showed twice daily entrainment of phase and period of ultradian behavioral rhythms associated with phase adjustment of the ultradian cycle around the light–dark and dark–light transitions. These ultradian activity patterns also drove an ultradian feeding pattern. We used a unique approach to map this behavioral activity/feeding status to high temporal resolution (every 90 min) measures of plasma metabolite profiles across the 24‐h light–dark cycle. A total of 148 known metabolites were detected in vole plasma. Supervised, discriminant analysis did not group metabolite concentration by feeding status, instead, unsupervised clustering of metabolite time courses revealed clusters of metabolites that exhibited significant ultradian rhythms with periods different from the feeding cycle. Two clusters with dissimilar ultradian dynamics, one lipid‐enriched (period = 3.4 h) and one amino acid‐enriched (period = 4.1 h), both showed co‐expression with diurnal cycles. A third cluster solely comprised of glycerophospholipids (specifically ether‐linked phosphatidylcholines) expressed an 11.9 h ultradian rhythm without co‐expressed diurnal rhythmicity. Our findings show coordinated co‐expression of diurnal metabolic rhythms with rapid dynamics in feeding and metabolism. These findings reveal that ultradian rhythms are integral to biological timing of metabolic regulation, and will be important in interpreting the impact of circadian desynchrony and meal timing on metabolic rhythms.
Preoperative Range of Motion in Extension May Influence Postoperative Cervical Kyphosis After Laminoplasty
Authors: Ren Hai-long , Shen Xing , Ding Ruo-ting , Cai Hai-Bo , Zhang Gong-liang
Published: March 2023

Study Design.

Retrospective observational study.

Objective.

To investigate factors associated with cervical kyphosis after laminoplasty.

Summary of Background Data.

Many factors are reportedly associated with the deterioration of cervical curvature after laminoplasty, including cervical lordosis angle, cervical spine range of motion (ROM), T1 slope, and C2–7 sagittal vertical axis. Post-laminoplasty kyphosis or deterioration of cervical curvature is likely caused by multiple factors. There is currently no consensus on these issues.

Methods.

Data of patients treated with laminoplasty for degenerative cervical myelopathy at our institution during 2008–2018 were reviewed. The following variables were collected for each patient: age and sex; follow-up time; surgery involving C3 (yes or no); surgery involving C7 (yes or no); distribution of segments operated on; number of laminae operated on; flexion, extension, and total ROM; cervical lordotic angle; longitudinal distance index; curvature index; C2–7 sagittal vertical axis; and T1 slope. Logistic regression analysis was used to assess possible risk factors for postoperative kyphosis. Receiver operating characteristic curves were constructed to determine the cut-off values of risk factors.

Results.

The study cohort comprised 151 patients. Logistic regression analysis indicated that sex, number of laminae operated on, and preoperative extension ROM were significantly associated with postoperative cervical kyphosis (P<0.05). There was significantly greater postoperative kyphosis in women than in men; the more segments operated on, the greater the risk of postoperative kyphosis, and the larger the preoperative extension ROM, the lower the risk of post-laminoplasty kyphosis. Receiver operating curve analysis showed that the cut-off value for preoperative extension ROM is 22.1°.

Conclusion.

Preoperative extension ROM may be associated with the development of postoperative kyphosis. The cut-off value of preoperative extension ROM that suggested the prospect of postoperative kyphosis in our sample was 22.1°.
Are We Considering the Whole Patient? The Impact of Physical and Mental Health on the Outcomes of Spine Care
Authors: Turcotte Justin J. , Baxter Samantha , Pipkin Karen , Patton Chad M.
Published: March 2023

Study Design.

Retrospective, observational.

Objective.

To evaluate the influence of baseline health status on the physical and mental health (MH) outcomes of spine patients.

Summary of Background Data.

Spine conditions can have a significant burden on both the physical and MH of patients. To date, few studies have evaluated the outcomes of both dimensions of health, particularly in nonoperative populations.

Materials and Methods.

At their first visit to a multidisciplinary spine clinic, 2668 nonoperative patients completed the Patient-reported Outcomes Measurement Information System-Global Health (PROMIS-GH) instrument and a questionnaire evaluating symptoms and goals of care. Patients were stratified by their baseline percentile score of the MH and physical health (PH) components of the PROMIS-GH. Four groups of patients were compared based on the presence or absence of bottom quartile PH or MH scores. The primary end point was the achievement of a minimal clinically important difference (MCID) on the MH or PH components at follow-up. Multivariate regression assessed the predictors of MCID achievement.

Results.

After controlling for demographics, symptoms, and goals, each 1-point increase in baseline PROMIS-GH mental score reduced the odds of achieving MH MCID by 9.0% (P<0.001). Conversely, each 1-point increase in baseline GH-physical score increased the odds of achieving MCID by 4.5% (P=0.005). Each 1-point increase in baseline GH-physical score reduced the odds of achieving PH MCID by 12.5% (P<0.001), whereas each 1-point increase in baseline GH-mental score increased the odds of achieving MCID by 5.0% (P<0.001).

Conclusions.

Spine patients presenting with the lowest levels of physical or MH were most likely to experience clinically significant improvement in those domains. However, lower levels of physical or mental health made it less likely that patients would experience significant improvement in the alternative domain. Physicians should evaluate and address the complex spine population holistically to maximize improvement in both physical and mental health status.
One-year Postoperative Radiographic and Patient-reported Outcomes Following Cervical Deformity Correction Are Not Affected by a Short-term Unplanned Return to the OR
Authors: Fourman Mitchell S. , Lafage Renaud , Ames Christopher , Smith Justin S. , Passias Peter G. , Shaffrey Christopher I. , Mundis Gregory , Protopsaltis Themistocles , Gupta Munish , Klineberg Eric O. , Bess Shay , Lafage Virginie , Kim Han Jo ,   on behalf of the International Spine Study Group
Published: March 2023

Study Design.

Retrospective analysis of a prospectively collected multicenter database.

Objective.

The objective of this study was to assess the radiographic and health-related quality of life (HRQoL) impact of a short-term (<1 y) return to the operating room (OR) after adult cervical spine deformity (ACSD) surgery.

Summary of Background Data.

Returns to the OR within a year of ACSD correction can be particularly devastating to these vulnerable hosts as they often involve compromise of the soft tissue envelope, neurological deficits, or hardware failure. This work sought to assess the impact of a short-term reoperation on 1-year radiographic and HRQoL outcomes.

Materials and Methods.

Patients operated on from January 1, 2013, to January 1, 2019, with at least 1 year of follow-up were included. The primary outcome was a short-term return to the OR. Variables of interest included patient demographics, Charlson Comorbidity Index, HRQoL measured with the modified Japanese Orthopaedic Association), Neck Disability Index, and EuroQuol-5D Visual Analog Scale (EQ-5D VAS) and radiographic outcomes, including T1 slope, C2–C7 sagittal Cobb angle, T1 slope–Cobb angle, and cervical sagittal vertical axis. Comparisons between those who did versus did not require a 1-year reoperation were performed using paired t tests. A Kaplan-Meier survival curve was used to estimate reoperation-free survival up to 2 years postoperatively.

Results.

A total of 121 patients were included in this work (age: 61.9±10.1 yr, body mass index: 28.4±6.9, Charlson Comorbidity Index: 1.0±1.4, 62.8% female). A 1-year unplanned return to the OR was required for 28 (23.1%) patients, of whom 19 followed up for at least 1 year. Indications for a return to the OR were most commonly for neurological complications (5%), infectious/wound complications (5.8%), and junctional failure (6.6%) No differences in demographics, comorbidities, preoperative or 1-year postoperative HRQoL, or radiographic outcomes were seen between operative groups.

Conclusion.

Reoperation <1 year after ACSD surgery did not influence 1-year radiographic outcomes or HRQoL.