bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on the influencing factors of traceability information sharing of agricultural product supply chain under the background of blockchain
Authors: Ren Xiang Yang , Zheng Yu Xue , Zhou Na
Published: September 2024

Increasing customer apprehensions regarding the security and nutritional value of agricultural goods are compelling governments and industries to implement traceable, transparent, and reputable logistics management systems. Blockchain-based agricultural logistics management systems guarantee the permanence of data once it is uploaded but cannot cope with the risk of data being falsified before uploading to the blockchain. In this work, we developed a collaborative game model between government bodies and agricultural enterprises based on the evolutionary game theory and explored the influencing factors of enterprises following the rules to share the real traceability information through numerical simulation using MATLAB. The findings show that government incentives and penalties promote positive behavior, and consumer and media supervision contribute to supply chain transparency, but firms tend to share truthful information only when it benefits them. This study builds upon existing research on the impact of social variables on both members' decision-making behavior. It highlights the positive roles of consumers and the media in the supervision of agricultural product traceability, which can help to raise public awareness of social responsibility and thus promote positive interaction in the market.
Novel Paediatric Extended Release Mini-Tablets Formulation and Characterization of Lamotrigine by Design of Experiment (DoE)
Authors: R. Kumaravelrajan , D. Janaki. , V. Suba , Prasad Mohanta Guru , Prasad P. Dharani
Published: September 2024

The mini-tablets formulations have high patient compliances especially paediatrics and geriatrics The present investigation was to develop and compare HPMC K100 M and HPMC K4 M, a combination of processing variables of 32 factorial design factors, in the formulation of 100mg lamotrigine sustained drug release of mini-tablets for paediatric usage. The amount of lamotrigine in each little tablet is 25mg, and they were made using the direct compression method. Dependent variables included drug release and tensile strength. Drug release was sustained for at least 12 hours across all formulations. The drug release was proportional to the HPMC K4M and HPMC K100M concentrations. The dosages of 2, 4, and 6mg were also kept constant. When mini-tablets prepared with combination of polymers (12mg), F8 exhibits a tensile strength of 3.42N/m2 (6mg). Through numerical optimization, HPMC K4M = 11.0mg and HPMC K100 M = 4.50mg were discovered, resulting in 95.4 percent drug release and 3.1 (N/m2) tensile strength. An in vivo study with the optimized formulation in rats showed (AUC 0-t) and (AUMC 0-t) of 1123.4 (h)* (µg/ml) and 3313 h2* (µg/ml) respectively. Cmax and Tmax were 375.0µg/ml and 4 h.
Formulation and Evaluation of Antimicrobial Gels using Essential Oils
Authors: Kulkarni Vaishali , Jain Nayana , Shinde Rutuja , Kamble Swarda
Published: September 2024

Herbal Formulation has been accepted as a therapeutic agent for several diseases, due to its efficiency AND fewer side effect. This present research has been undertaken with the aim to formulate & evaluate herbal antimicrobial gels using essential oils (Rose Oil, Almond oil, Lemon Oil, Citronella Oil) gel formulations were prepared using Carbopol 940, ethanol, PEG 400 and required amount of distilled water. The physical parameters of formulated gels like colour, homogeneity, pH, viscosity and spreadability were evaluated. The gels were evaluated for antibacterial efficiency by the agar diffusion method against S. Aureus, E. coli. The herbal gels showed that formulations containing Essential oils have better antibacterial activity.
Exploring Aquasomes: A Promising Frontier in Nanotechnology-based Drug Delivery
Authors: Kumar Sarella Prakash Nathaniel , Vegi Srujala , Kumari Vendi Veera , Kumar Vipparthi Anil , Valluri Surekha
Published: September 2024

Nanotechnology has revolutionized the field of drug delivery, providing novel strategies to enhance drug efficacy and reduce side effects. Among these advancements, Aquasomes have emerged as promising nanocarriers, representing a unique class of colloidal delivery systems. Aquasomes are three-dimensional, self-assembling nanocomposites composed of a solid core coated with a layer of biocompatible polymers and stabilized by surfactants. Notably, the hydrophilic nature of Aquasomes allows them to encapsulate hydrophobic drugs, thereby overcoming solubility and stability challenges commonly associated with conventional drug formulations. The versatility of Aquasomes in encapsulating a wide range of drug molecules, including small molecules, proteins, and nucleic acids, expands their potential in various therapeutic areas. The applications of aquasomes are examined in targeted drug delivery, enabling site-specific release and minimizing off-target effects in this review. Moreover, the advantages of Aquasomes in improving drug stability and bioavailability are analyzed, and comparative assessments with other nanocarriers are presented. The potential challenges and ongoing research efforts to optimize Aquasome formulations for clinical translation are also discussed. Aquasomes offer a promising outlook for nanotechnology-based drug delivery, showing great potential in addressing existing limitations of conventional drug formulations. The constant progress in Aquasome research fuels optimism for their integration into mainstream therapeutics, revolutionizing medical treatments and patient outcomes.
Pharmacovigilance: Past, Present and Future
Authors: P. Londhe Vikas , Chanshetti Rahul , Dhole S.N.
Published: September 2024

Pharmacovigilance is a field now everyone in healthcare industry is well aware of. Pharmacovigilance study ensure that the medicine consumed by patient is effective enough to be sell in market and having less harm as compared to its benefit. Historically the medicine safety was not the prime focus during approval of medicine but some unforeseen events happened in past emphasized the need of stringent rules and regulation on drug research and approval process. Though many events happened in past which harmed the mankind seriously but thalidomide was the biggest tragedy happened and turning to be the stepping stone of modern pharmacovigilance. Many countries like USA, Japan and UK realized the importance of pharmacovigilance to ensure patient safety and took serious steps to regularize the drug development process. At collaborative level also many countries come forward to strengthen pharmacovigilance. World health organization (WHO)-Uppsala Monitoring Centre, Council for International Organizations of Medical Science (CIOMS), International council on harmonization (ICH) and Good Pharmacovigilance Practice (GVP) are the bodies which lay down stringent rules and regulations on drug development process and primarily focused on drug safety. Now pharmacovigilance come long a way since its inception back in history, and modern pharmacovigilance is not remains limited to only check effectiveness and safety of medicine but its ensuring the patient safety. It uses many advance tools and trends for effective pharmacovigilance process and to dig more and more safety data related to medicine which finally uses to ensure patient safety.
Diabete di tipo 1 con anticorpi negativi: quando è importante cercare un'altra diagnosi
Authors: Gulisano Chiara , Marazzi Camilla , Bassi Marta , Tantari Giacomo , d'Annunzio Giuseppe , Minuto Nicola
Published: September 2024

A 15-year-old girl presented with diabetes mellitus without ketoacidosis, initially treated as type 1 diabetes (T1DM). Despite a family history of diabetes, the patient showed reduced insulin requirements (0.3 U/kg/day) and tested negative for autoantibodies associated with T1DM. Following ISPAD guidelines, genetic testing was performed, revealing a heterozygous mutation in the HNF4α gene, associated with MODY 1 (Maturity-Onset Diabetes of the Young). The patient maintained good glycemic control with insulin therapy, but the case raises questions about the timing and approach to transitioning to sulfonylureas, the first-line treatment for MODY 1, which could potentially improve glycemic control and the quality of life.
Le manifestazioni parossistiche non epilettiche
Authors: Tratta Eleonora , Piacentini Francesca , Pelosi Paolo , Cupone Roberta , Mirri Silvia , Bini Rita , Mirri Gianpaolo , Ferrara Giovanna
Published: September 2024

A 9-month-old infant, under follow-up for neonatal sepsis due to Streptococcus agalactiae, presented to the Emergency Department with episodes of head drooping, sometimes accompanied by blinking. During the clinical examination, the infant showed normal tone and motor skills. The video EEG revealed episodes of forward head flexion without EEG correlation. The diagnosis was nonepileptic paroxysmal manifestations, known as ‘nonepileptic head drops’. It is essential to distinguish these manifestations from epileptic seizures to prevent misdiagnosis and inappropriate treatments.
PERFIL DE MUTAÇÕES GERMINATIVAS IDENTIFICADAS EM PAINEL MULTIGENES PARA PREDISPOSIÇÃO AO CÂNCER HEREDITÁRIO
Authors: Barbosa FB , Marotti TF , Ribeiro PD , Silva AFA , Oliveira DSL , Rodrigues MA , Paiva IS , Lopes GAMD
Published: September 2024

Objetivo: Avaliar a ocorrência de mutações germinativas em genes relacionados à síndrome de predisposição hereditária ao câncer (SPHC) em pacientes de risco, indicados para teste genético. Método: Foram incluídos 48 pacientes com ao menos um critério clínico para SPHC, atendidos no período de maio de 2020 a maio de 2022. A análise compreendeu nove painéis multigenes cuja patogenicidade das variantes detectadas por sequenciamento de nova geração foi estabelecida de acordo com os critérios de classificação da ACMG. Conclusão: Foram identificadas variantes patogênicas em 13% dos pacientes. Dentre elas, a variante missense no gene TP53 está associada à síndrome de Li-Fraumeni [OMIM:151623], enquanto duas variantes frameshift presentes em pacientes distintos, nos genes ATM e BRCA2, estão relacionadas com a síndrome de câncer de mama e ovário hereditário [OMIM:612555]. A detecção da mutação no BRCA2 foi imprescindível ao norteamento da localização do tumor primário em paciente com descoberta tardia de carcinomatose peritoneal. Deleção patogênica no gene MLH1 foi identificada em duas pacientes, o que confirmou a síndrome de Lynch [OMIM:609310] em uma delas e em outra, aliada à história de carcinoma sebáceo, validou-se a suspeita clínica de síndrome de Muir-Torre [OMIM:158320], relacionada com um risco aumentado para o desenvolvimento de neoplasias de glândulas sebáceas em associação a pólipos adenomatosos do cólon. A variante nonsense relatada no gene APC confirmou a hipótese diagnóstica de polipose adenomatosa familial [OMIM:175100] em paciente com múltiplos pólipos colônicos e ampla história familiar de neoplasias gastrointestinais. Em 48% dos indivíduos, entre uma e quatro variantes de significado clínico incerto foram reportadas, envolvendo 26 genes. Os resultados indicam que o uso de painéis multigenes pode nortear a estratificação do risco, além de mediar decisões terapêuticas que impactam diretamente na assistência aos pacientes e aos seus familiares.
O AUMENTO DA PROPORÇÃO DE EXAMES POSITIVOS PARA COVID-19 EM UM LABORATÓRIO DO INTERIOR APÓS A FLEXIBILIZAÇÃO DO USO DE MÁSCARAS NO ESTADO DE SÃO PAULO
Authors: Souza M , Maciel DC , Nery LFA , Araujo CM , Barreto BO
Published: September 2024

Objetivo: O Sars-CoV-2, agente etiológico da Covid-19, pertence à família dos coronavírus. Pacientes infectados podem apresentar sintomas leves a graves, sendo grande parte da população portadores assintomáticos(1). Assim, este trabalho tem como objetivo analisar dados referentes ao número de exames positivos em um laboratório do interior, face ao período posterior à flexibilização do uso de máscaras no estado de São Paulo. Método: Com uma metodologia observacional analítica, os dados coletados no período de 17 de março a 12 de maio de 2022 com relatórios de exames realizados versus resultados obtidos foram estatisticamente analisados. Os testes inclusos como parâmetro de pesquisa foram: o teste molecular para detecção do coronavírus Sars-CoV-2, o teste molecular com amplificação isotérmica e a detecção qualitativa de antígenos de Sars-CoV-2. Conclusão: As principais vias de transmissão do Sars-CoV-2 são transmissões por gotículas e contato; a transmissão aérea pode ser possível em circunstâncias e configurações específicas em que os procedimentos de geração de aerossol (AGP) são realizados. Em 17 de março de 2022, o governo do Estado de São Paulo decretou em Diário Oficial a flexibilização do uso de máscaras em todos os ambientes, exceto em unidades de saúde, hospitais e transportes públicos. Dessa forma, o total de exames referentes a março foi de 415, com um percentual de 9,40% de positividade. Em abril, o total de exames foi de 710 testes, com 13,8% de resultados positivos. No mês de maio até a data de coleta dos dados (12 de maio de 2022) foram 398 testes, com 29,65% de positividade. Portanto, esse crescimento na positividade dos testes nas últimas semanas corrobora a hipótese de que a flexibilização no uso de máscaras pode ter contribuído para esse avanço no número de casos. Referências: 1. Michelon CM. Principais variantes do SARS-Cov-2 notificadas no Brasil. RBAC; 53(2): 109-16.
PREVALÊNCIA DO VÍRUS SINCICIAL RESPIRATÓRIO NA POPULAÇÃO PEDIÁTRICA EM UM HOSPITAL TERCIÁRIO DO SUL DO BRASIL
Authors: Rodrigues GM , Hellwig AHS , Cavatão FG , Gomez EW , Giordani L , Paris F , Pereira DC , Paiva RM , Barth AL
Published: September 2024

Objetivo: Reportar a prevalência de vírus sincicial respiratório (RSV) em amostras de swab de nasofaringe na população pediátrica (0 a 5 anos) com suspeita de infecção por Sars-CoV-2 atendida no Hospital de Clínicas de Porto Alegre (HCPA) no período de janeiro a abril de 2022. Método: Estudo retrospectivo realizado de janeiro a abril de 2022. A pesquisa de RSV foi realizada por meio do ensaio de PCR multiplex Resp-4-Plex no analisador Alinity™ m (Abbott Molecular, EUA). Esse ensaio detecta simultaneamente os vírus influenza A (FLUA), influenza B (FLUB), RSV e Sars-CoV-2 em amostra de swab de nasofaringe. Conclusão: O RSV foi detectado em 136 amostras, das quais 94 (69%) eram de pacientes de 0 a 5 anos (n = 521). Foi possível observar um aumento de casos positivos na população pediátrica, sendo 1,39% (1/72) de positividade em janeiro, 9,57% (9/94) em fevereiro, 14,47% (23/159) em março e 30,35% (61/201) em abril. A avaliação por faixa etária (janeiro-abril de 2022) permitiu a observação de 17% (28/170) de positividade para RSV em crianças < 6 meses de idade, 24% (16/67) em crianças de 6 meses a 1 ano e 18% (50/284) em crianças de 1 a 5 anos. Foi possível identificar um aumento da prevalência de RSV na população pediátrica no HCPA. Foi observado um aumento de casos de RSV entre os meses de janeiro e abril de 2022, corroborando a sazonalidade desse vírus descrita na literatura. O maior número de casos foi detectado entre crianças de 6 meses a 1 ano de idade, faixa etária cuja vigilância viral é mais importante devido às complicações clínicas. Este ensaio multiplex possibilita um diagnóstico etiológico diferencial com o uso da mesma amostra clínica.
COMPARISON OF THE ION-EXCHANGE PROPERTIES OF CARBON ION-EXCHANGERS SYNTHESIZED ON THE BASIS OF APRICOT AND PEACH STONE SHELLS
Authors: Martirosyan V.G. , Sarkisova Yu.S. , Kazinyan A.A.
Published: September 2024

The aim of the work is the synthesis of carbon ion-exchangers from the apricot and peach stone shells, the study of their ion exchange properties, including in the process of purification wastewaters from radioactive isotopes, and comparison of ion exchange properties obtained on the basis of shells of apricot and peach stones of carbon ion-exchangers. The process of carbonization of the apricot stone shells in the temperature interval of 400-4500C and of the peach stone shells in the temperature interval of 450-5000C with the process duration of 1-2 hours in the nitrogen medium have been studied. Activation was carried out in the heated water vapor medium at temperatures of 750-10000C and with the process duration of 1-5 hours. To improve the ion-exchanging and selective properties of the obtained stone’s carbons, the oxidation process of carbonized and activated carbon was studied. The study of the ion-exchanging properties of carbon ion-exchangers (exchange capacity, the number of strong-acid carboxyl, weak-acid carboxyl and phenol groups, activity by adsorption Sr2+ and Cs+) were carried out. The obtained samples have been tested and investigated in detail at the Armenian Nuclear Power Plant. The investigations of the effectiveness of the filtering capability of the apricot and peach stone shells carbon ion-exchangers have been held in laboratory conditions NPP. The experiments have shown that the synthesized carbon ion-exchangers are capable of reducing the content of radioactive isotopes, in particular 134Cs and 137Cs isotopes, in the wastewater of the Armenian NPP by about 1000 times.
Exploring the Prevention and Treatment of Epilepsy based on the Theory of Ambrosia
Authors: Kan Xiaoru , Cheng Nan , Liu Jinghan , Wang Jiayue , Chen Jun
Published: September 2024

The theory of "Fu Xie" is one of the important theories in traditional Chinese medicine, which guides the prevention and treatment of many diseases, including epilepsy. Epilepsy is a common neurological disease with complex etiology and diverse clinical manifestations. According to the theory of "Fu Xie", epilepsy is caused by factors such as liver wind, phlegm turbidity, dampness evil, and fire heat. Therefore, the key to treating epilepsy is to clear these pathogenic factors and regulate the body's physiological functions such as Qi, blood, Yin, and Yang. In Chinese medicine treatment, drugs such as Chai Hu and Qing Pi can be used to regulate liver Qi and clear liver heat. Drugs such as Ban Xia and Zhi Shi can be used to clear heat, transform phlegm, and promote diuresis to eliminate phlegm turbidity. Drugs such as Qu Mai and Fu Ling can be used to strengthen the spleen, dispel dampness, and open the orifices to stop seizures. Drugs such as Huang Lian and Huang Qin can be used to clear heat, detoxify, nourish Yin, and reduce fire. The theory of "Fu Xie" has important guiding significance for the prevention and treatment of epilepsy, and can provide effective reference for clinical treatment.
Exploring the Mechanism of Action of the "Scutellaria Barbata D.Don-Prunella Vulgaris L." Herb Pair in the Treatment of Lung Cancer Using Network Pharmacology and Molecular Docking Techniques
Authors: Liu Hongzhi , Han Le
Published: September 2024

Objective: To explore the mechanism of action of the herbal pair "Scutellaria barbata D.Don-Prunella vulgaris L." in the treatment of lung cancer through network pharmacology and molecular docking techniques. Methods: Active ingredients and their targets of Scutellaria barbata D.Don and Prunella vulgaris L. were collected and screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Disease-related targets were obtained and screened from the Genecards and OMIM databases. The intersection Venn diagram of the targets of "Scutellaria barbata D.Don-Prunella vulgaris L." and lung cancer disease targets was obtained using R 4.4.1 software and packages such as "ggvenn". A drug-active ingredient-target-disease association network was constructed in Cytoscape 3.10.0, and core active ingredients were screened using the Analyze Network function. A PPI network for drug-disease common targets was constructed using the String database website, and the TSV format of protein interaction relationship files was imported into Cytoscape 3.10.0 software,install and run CytoHubba to calculate and obtain the core targets in the network. GO function and KEGG pathway enrichment analyses were performed on drug-disease common targets using R 4.4.1 software. Finally, molecular docking validation was performed on core ingredients and core targets using AutoDock, and the three best binding molecular docking patterns were displayed using PyMol software. Results: A total of 33 active drug components and 108 drug-disease common targets were obtained. Among them, there are 5 core active components: quercetin, luteolin, wogonin, kaempferol, and baicalein; core targets include TP53, AKT1, JUN, HSP90AA1, etc. GO analysis yielded 2, 010 related entries. KEGG analysis identified 147 signaling pathways. Molecular docking showed that the core active components have strong affinity with the core targets. Conclusion: The drug pair of Scutellaria barbata D.Don and Prunella vulgaris L. may exert anti-tumor effects by acting on targets such as TP53, AKT1, JUN, HSP90AA1, and through signaling pathways like PI3K-AKT, inhibiting tumor cell proliferation, promoting tumor cell apoptosis, suppressing its proliferation, differentiation, and metastasis, thereby achieving therapeutic effects on lung cancer.
Teaching Model of International Chinese Education from the Perspective of Cross-Cultural Communication
Authors: Zhan Haiyu
Published: September 2024

The essence of international Chinese education is the teaching, promotion and dissemination of Chinese language and culture, while the differences between Chinese and foreign cultures will create certain obstacles to this dissemination process. In order to cope with the challenges brought by cultural differences and make full use of their positive factors, this paper proposes the application strategy of diversified teaching models, including: first, the interpretation teaching model, which helps students establish a deep understanding of Chinese culture by deeply analyzing the cultural connotations behind Chinese language phenomena; second, the cultural collision teaching model, which encourages students to stimulate critical thinking and innovation in the process of comparing the differences between Chinese and foreign cultures; third, the research-based teaching model, which guides students to participate in cultural research and cultivate their independent learning ability and research literacy; fourth, the exemplary teaching model, which allows students to experience and learn the unique charm of Chinese language and culture in practice by showing representative cultural cases.
The Impact of Live Streaming of Fresh Agricultural Products on Consumers' Purchase Intention-Consider the Regulatory Role of Policy Support
Authors: Sun Fan
Published: September 2024

To understand the influence of fresh agricultural products online live on consumer purchase intention, based on SOR (Stimuli-Organism-Response) theory framework, with convenience, interactivity, anchor prestige, task fit as a stimulus variable, to customer participation as a psychological latent variable construction theory model, based on the questionnaire data, using the structural equation model of measurement model consistency, reliability, convergence validity and validity test, and explore the role of the latent variables, with path coefficient as an observation index analysis of the model results. The research results show that convenience, interactivity, anchor reputation and task fit have significant positive effects on customer participation, among which the biggest influence is convenience; in the process of convenience and interaction on customer participation, policy support plays a positive regulating role, in the process of anchor reputation and task fit on customer participation.
New era Dalian Strengthens to People in the Private Economy in Ideological and Political Studies
Authors: Li Kun
Published: September 2024

Private economy is an important part of China's national economy, playing an irreplaceable role. In the new era, private economy is faced with various difficulties due to the changes of international economic environment and the development of domestic economic situation. An in-depth analysis of the new characteristics of the ideological and political work of private economic personages in Dalian, by optimizing the development environment of private economy, perfecting the mechanism of ideological and political work of private economy, screening the content of ideological and political work that matches the actual needs of private economy development, and making full use of modern multiple carriers, etc., it is of great significance to strengthen the ideological and political guidance of private economic personages in Dalian.
Multiple Directions for Promoting High-quality Economic Development
Authors: Lu Wenyan
Published: September 2024

At present, promoting high-quality economic development has important practical needs and logical orientations. First, it is an inevitable requirement to accelerate the construction of a modern economic system; second, it is an inevitable requirement to accelerate the development of new quality productivity; third, it is to promote the development of high-level infrastructure, high-level protection, and high-level opening up.
Application of Case Teaching Method in Orthopedic Practice Teaching
Authors: Liu Zhicheng , Dong Jianxun , Sun Binghui , Zhao Bing , Yang Zhengke , Wu Xue
Published: September 2024

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The Effect of Water Sports on the Performance of Adolescent Boys
Authors: Hashash Yousef Al
Published: September 2024

In our education system sports has given the importance at school and college levels. Even though enriching athletic performance is a real problem in our country. Many rural students are up to the mark and willing for hardworking but due to lack of facilities they are lagging behind. Consequently, the participation of students in track and field athletics in Indian schools is also amazingly very less. They prefer major games because maximum incentives and importance are given by the sports world. Out media highlights mostly the sports starts of cricket, football, hockey, badminton, tennis, etc. but rarely gives importance to track and field athletes. Presently the status of 100 meters sprint event especially for boys have enriched as a competitive sports. The excitement and thrill provided by this particular event has won the heart of common man. After the pretest, with 100 meters sprint, the experimental group underwent a training programme of aqua exercises and control group did not participate in any training programme but they were following their daily routine in the school. The training program has been conducted three days in a week alternatively, for total period of 12 weeks. The training schedule prepared by the investigator was applied to the experimental group. The mid test of both the groups administered after every two weeks. A total five mid tests were administered and post test was administered after 12 week training program. The 100 meter sprint performance was considered as the main dependent variable as selected in this study and the training intervention (i. e. aqua exercises) was considered as independent variable. And finally it help to conclude that through the aqua exercise training program module there was gradual and useful improvement in performance ability of 100 meter sprint of school going boys.
A Study on the Utilization of Library Information Resources for Undergraduate Students in Women's Colleges of Government Level from 2017 to 2023
Authors: Alam Pravej
Published: September 2024

The aim of this study to find out the effective usage of Library and information resource from our college undergraduate students to develop their academic and career achievements. This study was only conducted for “BA” and, “Bcom” final year students from 2017 to 2023. Co - relation of the student’s response with their academic and currier achievement had significant relationship to their use of books and use of competitive magazines, reference material, and other electronic materials.
Beyond Technological Competence: Examining Digital Literacy and AI Integration in Language Teaching
Authors: Liu Xi
Published: September 2024

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Ecolinguistic Thinking on the Application of Information Technology in International Chinese Education
Authors: Zhan Haiyu
Published: September 2024

The existing education system cannot meet the Chinese learning needs of social groups well. There are certain problems in ecological, balanced and benign development. Since the new century, information technology has developed rapidly, and Internet technology has been widely used in cross-cultural education. Starting from the current development status of international Chinese education in the new era, this paper takes its healthy development as the guiding principle, explores the feasible ideas of promoting educational development through interdisciplinary studies from the perspective of ecolinguistics, proposes some development strategies for international Chinese education, strengthens the construction of international Chinese education response mechanism for emergencies, promotes the effective allocation of international Chinese education resources, and especially strengthens the in-depth application of modern information technology in all aspects and fields of international Chinese education.
Application of Translation Technology in Translation for International Public Relations of the Summer Davos Forum
Authors: Ma Na , Wei Ping
Published: September 2024

The Summer Davos Forum, also known as the Annual Meeting of the New Champions, is a significant international event that convenes global leaders, business executives, and experts to discuss pressing global issues. As the forum continues to expand its international reach, translation technology has become increasingly important in overcoming language barriers and facilitating effective communication among participants from diverse linguistic backgrounds. This paper examines the utilization of translation technology in the translation for international public relations of the Summer Davos Forum, focusing on its role in real-time interpretation, multilingual content creation, live streaming with subtitles, and post-event content translation. By harnessing the power of translation technology, the forum has been able to enhance its global visibility and engage with a broader audience, thereby ensuring the success and inclusivity of the event.
Spanish Survey of Household Finances (EFF) 2022: methods, results and changes since 2020
Authors: BANCO DE ESPAÑA BANCO DE ESPAÑA
Published: September 2024

This paper presents the main results of the Spanish Survey of Household Finances 2022, which reflect the financial situation of Spanish households as at end-2022. These results are of particular interest, since they allow the income, assets, debt and spending of Spanish households to be analysed in a context of particularly high uncertainty, amid the latter stages of the pandemic, supply chain problems and extraordinary energy and commodity price increases. The paper also describes the key changes in those variables since the last edition of the survey (2020).
ВЛИЯНИЕ ДЕЯТЕЛЬНОСТИ ЧЕЛОВЕКА НА ПЕРЕДАЧУ ЗООНОЗНЫХ ИНФЕКЦИЙ (ОБЗОР ЛИТЕРАТУРЫ)
Authors: Акпанова Т.Ж. , Рахыпбеков Т.К. , Керимбаева З.А. , Мусаханова А.К. , Раисова К.А. , Асан А.А.
Published: September 2024

По мере того, как люди изучают, исследуют новые территории на планете, такие действия, как вырубка лесов, урбанизация, туризм, эксплуатация дикой природы и изменение климата, могут иметь серьезные последствия для взаимодействия между животными и людьми и привести к росту зоонозных заболеваний. Приблизительно 60% новых человеческих патогенов и около 75% всех новых инфекционных заболеваний относятся к категории зоонозных, в этой связи важно изучить влияние деятельности человека на распространенность и передачу инфекционных агентов. Целью работы является изучение факторной обусловленности здоровья населения и влияние различных факторов на рост зоонозных инфекций. Стратегия поиска: анализ публикаций по теме исследования, источников индексируемых в базах данных электронной библиотеки e-Library, Google Академия, Pubmed, Web of Science, Scopus.
METHODS OF ANTI-RABIC IMMUNOGLOBULIN PRODUCTION
Authors: Bitanova E.Zh. , Akhmetsadykov N.N. , Abdraimova Zh.A. , Batanova Zh.N. , Baikara B.T. , Bayandy G.A. , Krykbayev Y.A. , Nurmuhambetova A.B. , Imanbekova T.A.
Published: September 2024

Rabies belongs to the group of dangerous infectious diseases of humans and animals, marked by damage to the central nervous system and utter mortality, and is one of the most prevalent zooanthroponoses. And in Kazakhstan, rabies is enzootic in more than 20% of the territory. Purpose of the study: Analysis of literature sources on topics connected to methods for acquiring rabies immunoglobulin from different animal producers and comparison of their effectiveness. Search strategy: The search for sources was carried out in such databases as PubMed, Scopus, and Web of Science. The search depth was 61 years from 1959 to 2020, and as this is an ancient disease, it has consequently been thoroughly investigated by scientists around the world. Twenty literature sources provide crucial conceptual information on this topic. Inclusion criteria: literature reviews, original articles; publications in open access with full text in English and Russian. Exclusion criteria: publications of low methodological quality, conference materials. 53 full-text, critically evaluated papers and four statistical office reports and data were selected for examination. Results and conclusions: Obtaining rabies immunoglobulin from the serum of a horse inoculated against rabies is a successful and economical procedure. But at the present, nanobody therapy is regarded as a very promising solution for the treatment of complex viral infections.
ВАРИАБЕЛЬНОСТЬ СЕРДЕЧНОГО РИТМА У БОЛЬНЫХ С ИНТЕРСТИЦИАЛЬНЫМИ ЗАБОЛЕВАНИЯМИ ЛЕГКИХ
Authors: Ибраева Л.К. , Алина А.Р. , Бачева И.В. , Рыбалкина Д.Х. , Жанабаева А.С. , Классен О.С. , Аубакирова М.К. , Борчашвили С.А.К. , Мурзабаев А.А. , Мукатова А.А.
Published: September 2024

Распространенность интерстициальных заболеваний легких (ИЗЛ) во всем мире достаточно велика и связана со значительными затратами на здравоохранение. ИЗЛ высоко инвалидизирующие заболевания, часто приводят к дисфункциям сердечно-сосудистой системы, поэтому важно оценивать функциональный статус пациентов. Цель исследования: изучение показателей ВСР у пациентов с ИЗЛ. Материалы и методы. Были исследованы 29 человек с диагностированными ИЗЛ различного генеза и 25 относительно здоровых человек. Критерии включения в исследование: пациенты с ИЗЛ; возраст от 25 до 60 лет; NYHA I-II стадии; СКФ выше 60 мл/мин. ВСР оценивалась с помощью аппарата "Варикард 3.0" и программы ИСКИМ 6 (Рязань). Результаты. В группе пациентов с ИЗЛ отмечалось снижение значений абсолютных и нормализованных показателей LF (низкочастотный диапазон спектра ВСР 0,04–0,15 Гц), HF (высокочастотный диапазон спектра ВСР, 0,15–0,4 Гц), RMSSD мс (квадратный корень из среднеквадратичных разностей последовательных интервалов NN), pNN50 % (процент количества пар последовательных кардиоинтервалов, различающихся более чем на 50 мс), SDNN мс (стандартное отклонение всех кардиоинтервалов NN). Статистически значимые изменения были обнаружены среди абсолютных и стандартизированных показателей LF n.u., HF n.u., pNN50 %, отражающих активность парасимпатического звена вегетативной регуляции. Заключение.Таким образом, у пациентов с ИЗЛ в сравнении со здоровыми людьми отмечалось снижение активности парасимпатической системы, что может быть отражением тяжести заболевания, вследствие рецидивирующей гипоксемии, увеличения дыхательных усилий в результате уменьшения объема легких из-за наличия фиброза легких.
БОСАНУДАН КЕЙІНГІ АНА ӨЛІМІНІҢ АЛДЫН АЛУДАҒЫ ҰЙЫМДАСТЫРУШЫЛЫҚ АСПЕКТІЛЕРІ ТҮРКІСТАН ОБЛЫСЫ МЕН ШЫМКЕНТ ҚАЛАСЫНДА (Әдеби шолу)
Authors: Тоқбергенова А.Б. , Сарсенбаева Г.Ж. , Ахметова Л.В. , Бектенова Г.Е. , Токкулиева Б.Б. , Дарипбекова К.Ж. , Доланова Г.О. , Серік Б.Б.
Published: September 2024

Ана өлімі Денсаулық сақтау жүйесі жағдайының сезімтал көрсеткіштерінің бірі болып табылады. Бұл шолу ана өлімі мен аурушаңдықты азайту және алдын алу тәсілдерін сипаттайды. Ана ауруын, өлім-жітімді азайту және акушерлік қауіпсіздікті жақсарту бойынша көптеген жұмыстар талқыланды. Бұл жұмыста ана өлімі мәселесі бойынша әлемдік медициналық журналдарға және ДДҰ деректеріне, сондай-ақ Қазақстан Республикасы Денсаулық сақтау министрлігінің деректеріне жүйелі шолу жүргізілді. Мақалалар дәлелді медицина, Google Scholar, PubMed, Scopus және Web of Science сайттарынан алынды. Бұл мақалада ана өлімінің себептері, азайтудың әдістері мен оңтайлы стратегияларына шолу берілген. Ана өлімін азайту шаралары перинаталдық денсаулық сақтауға қатысатын барлық мүдделі тараптар арасындағы байланыс пен ынтымақтастықты, сондай-ақ ана денсаулығының негізгі салаларын қамтитын ұлттық пакеттерді құруды, барлық акушерлік ауруханаларды ананың ауыр сырқаттануының барлық жағдайларын қарауға және талдауға шақыруды қамтиды. Қазіргі әлемдегі ана өлімі проблемасы өзектілігін сақтайды және ана өлімін азайту және орын алмаған ана өлімін есепке алу жөніндегі шараларды ұдайы жетілдіруді талап етеді.
HELICOBACTER PYLORI STATUS IN CHILDREN WITH GASTROINTESTINAL DISEASES
Authors: Rysbayeva Zh.I. , Karkimbayeva G.A. , Uatayeva A.T. , Izenbaev N.B. , Konysbayev M.G , Karzhaubaeva M.M.
Published: September 2024

In recent years, the attention of researchers in the field of dentistry and gastroenterology has been drawn to the problem of the participation of the oral cavity in the development of a number of diseases of the gastrointestinal tract. The purpose of the study was to determine Helicobacter pylori status in children with gastrointestinal diseases. The work determined the dental and pediatric status of children with gastroduodenal diseases. A microbiological study was carried out to determine Helicobacteraceae in the oral cavity. 7 Helicobacteraceae isolates of three species were isolated: Helicobacter fennelliae (1) in 2.4% of cases, Helicobacter pullorum (1) in 2.4% of cases (opportunistic forms), Helicobacter pylori (5) in 12.2% of cases (pathogenic form). In children with gastroenterological pathology, the oral Hp contamination in the oral cavity was 17.1% and there was scanty to abundant growth of the Hp colony (from 102 to 104 CFU/g). Determining the contamination of the oral cavity with Helicobacter pylori infection may be the method of choice for screening.
Investigating The Relationships Between Factors Affecting Performance in IT
Authors: Mathur Nidhi , Agarwal Nimmi , Saxena Rahul
Published: September 2024

Background: Information technology (IT) sector employee working can be awakening and fulfilling beneath theumbrellaof great sustaining solid working environment. In common, the working environment could be a imperative for enabling well-being at work and in common life and work satisfaction. IT segment worker may find it fulfilling when their employements offer openings for both person development and definitive progress. Aim: The purpose of this research is to look at the relationship between job satisfaction, job stress and performance of IT workers collectively, so that we can get information about how they generally affect each other and, also their affect on employee well-being along with the organizational tasks in the IT sector. Methodology: This mixed method examines the confounding relationship between job satisfaction, job stress and job performance (job related factors) in the IT industry. It includes quantitative reviews and subjective interviews with 150 IT sector employees that reveal unbridled measurements of their well-being and execution. Result: The results of this quantitative study show that job satisfaction was negatively correlated with stress and positively correlated with performance (r = -0.538, p < 0.05; r = 0.692, p< 0.001). Job stress is influenced by variables such as tight deadlines and constant demands on talent. Undoubtedly, organizational support, including training programs and work-life adjustment, will become the main regulator of these relationships. In addition, qualitative experiences give depth to these quantitative events. Conclusion: Adaptive components of work stress, including social back and attention as an important part to improve the well-being of IT workers, are recommended. This study contributes to a comprehensive understanding of job satisfaction and job stress in the IT industry and provides important recommendations to optimize the well-being and performance of IT workers in this energetic and challenging industry.
Síndromes de insulinorresistencia severa ligados a mutaciones en el gen que codifica el receptor de la insulina
Authors: Losada Calderón Bryan Nicolás , Almeida Mora Pablo Alejandro , García Mármol Jesús Gabriel , Corrales Santander Hugo Rafael
Published: September 2024

Contexto: el síndrome de insulinorresistencia de origen genético es una entidad rara y subdiagnosticada, con manifestaciones clínicas variables que van más allá de los trastornos de la homeostasis de la glucosa.
Objetivo: realizar una revisión narrativa sobre la fisiopatología, genética, manifestaciones clínicas, diagnóstico y tratamiento de los síndromes de insulinorresistencia severa ligados a mutaciones del gen que codifica el receptor de la insulina (INSR, según sus siglas en inglés).
Metodología: revisión de la literatura en las bases de datos PubMed, Scielo y en literatura gris en el buscador del repositorio de la Universidad Nacional de Colombia. Se utilizaron en la búsqueda los términos MeSH: “Insulin Resistance”, “Donohue síndrome”, “Receptor, Insulin”, “Physiopathology”, “signs and symptoms”, “Diagnosis”, “Genetics”, “Pharmacological Treatment” y revisión del listado de referencias bibliográficas (en “bola de nieve”) de los estudios seleccionados.
Resultados: los síndromes de insulinorresistencia severa ligados a mutaciones del receptor de la insulina comprenden un espectro de condiciones genéticas causadas por variantes patogénicas en el INSR, que se pueden manifestar en un continuo de características clínicas y alteraciones bioquímicas desde formas que amenazan la vida en el periodo neonatal hasta formas leves que pueden pasar subdiagnosticadas y confundidas con diabetes tipo 2. El tratamiento de estas condiciones se basa en una aproximación a la fisiopatología y en reportes anecdóticos, más que en evidencia proveniente de ensayos clínicos.
Conclusiones: dada la rareza de los síndromes de insulinorresistencia ligados a anomalías del gen del receptor de la insulina, aún su diagnóstico y su tratamiento son un reto en la práctica clínica.
Thermal performance and energy efficiency of bio-sourced insulated roofs
Authors: Aidi Moussa , Harnane Yamina , Bordja Lyes
Published: September 2024

This study investigates the thermal behavior of building roofs, which are critical for internal cooling and energy savings due to their direct exposure to weather conditions, particularly solar radiation. Maintaining a stable interior surface temperature close to optimal thermal comfort values for occupants is essential. The study emphasizes the importance of selecting insulating materials and processes that effectively reduce heat flow through the roof. Heat received on the exterior roof surface is absorbed and transmitted indoors via conduction. Roofs with a large thermal mass can store most of this heat within the materials. Insulation is identified as the optimal solution for achieving thermal comfort. Using numerical simulations with Fluent 15.0 software, the thermal behavior of different types of roofs, including a bare reference slab and slabs composed of layers with bio-sourced insulating materials (straw, cellulose wadding, wood wool, and cork), was examined. Results show that energy consumption improved by more than 80% for all types of bio-sourced materials. Additionally, the composite slab was applied to a closed cavity, representing a living room, to predict the thermal comfort of the space.
Enhancing bio-composite performance: mechanical properties of Diss fibre-reinforced epoxy
Authors: Khalfi Mehdi , Bouakba Mustafa , Bennouna Mohammed Salah
Published: September 2024

As industries increasingly adopt composites for their superior stress resistance, the high cost and environmental challenges associated with their disposal remain significant concerns. Bio-composites offer a sustainable alternative by addressing these issues with better recyclability and lower environmental impact. This study explores the mechanical performance of a bio-composite featuring Diss fibres embedded in an epoxy matrix. We conducted tensile and Charpy impact tests to measure Young's modulus and impact energy, respectively. Different weight percentages of Diss fibres (wtD%) were used to prepare the specimens. The findings indicate that the Young's modulus of the bio-composite peaked at 1.30GPa with 20wtD%, after which it declined. The incorporation of Diss fibres notably enhanced the tensile strength of the samples compared to the pure epoxy matrix. Additionally, impact energy increased with higher wtD%, reaching a maximum of 3.5J at 30wtD%. These results suggest that Diss fibres are a viable reinforcement material for developing greener composites.
Enhancing safety in narrow-band transformerless PLC couplers with a passive symmetrical filter
Authors: Chatbi Hamid , Tadjer Sid Ahmed , Chekired Fathia , Tercha Wassila
Published: September 2024

As the demand for efficient data transmission over existing power infrastructure grows, power-line communication (PLC) systems have become increasingly vital. However, integrating communication signals with high-voltage power lines poses significant safety challenges, emphasizing the need for reliable, safe, and high-performance components. To address cost and safety concerns, this article introduces a symmetrical third-order band-pass filter design that employs a transformerless coupler, avoiding the expense and bulk of traditional transformers while enhancing both equipment and human safety in narrow-band PLC systems. The design, functionality, and safety considerations are discussed, with a focus on implementing a passive analog Butterworth filter, chosen for its flat frequency response in the passband. Additionally, we address the safety aspects of transformerless couplers in PLC applications, emphasizing their reliability and efficiency in maintaining signal integrity while minimizing the risks associated with high-voltage environments. Simulations validated the proposed design, confirming its effectiveness in achieving the desired frequency response. The design is cost-effective due to the elimination of the transformer and ensures safety through the strategic rearrangement of the coupler components, which isolates the power line from the communication side.
Removal process of an industrial dye using a biosorbent: characterization, kinetic, equilibrium, and thermodynamic studies
Authors: Ziane-Hezil Samira , Bessaha Fatiha , Bessaha Gania , Boucif Fatima , Mahrez Nouria
Published: September 2024

Adsorption-based removal is a highly efficient environmental phenomenon employed to eliminate various dyes, such as crystal violet (CV), which is prevalently used in the textile industry and subsequently discharged into natural ecosystems. This study aims to utilize natural bentonite clay sourced from Algeria for the extraction of cationic dye (CV) from wastewater. The characterization of the bentonite was conducted using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and X-Ray Diffraction (XRD). Evaluations assessed the impact of various parameters including pH, stirring time, temperature, and initial dye concentration on the adsorption efficiency. Optimal conditions for the maximal adsorption of CV were determined to be 430.18 mg g-1 at an adsorbent-to-dye solution ratio of 1 g L-1, pH 11.06, an equilibrium time of 40 minutes, and a temperature of 40°C. The adsorption kinetics were best described by the pseudo-second-order model, while the Freundlich isotherm model aptly described the adsorption isotherms. Thermodynamic parameters underscored the spontaneous and exothermic nature of the crystal violet removal process using raw bentonite. This research provides novel insights into the effective removal of a cationic dye from water and wastewater using Algerian bentonite clay.