bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatic TORC2 Signaling Facilitates Acute Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice
Authors: Kim Teayoun , Nason Shelly , Antipenko Jessica , Finan Brian , Shalev Anath , DiMarchi Richard , Habegger Kirk M
Published: July 2022

Long term glucagon receptor (GCGR) agonism is associated with hyperglycemia and glucose intolerance, while acute GCGR agonism enhances whole-body insulin sensitivity and hepatic AKTSer473 phosphorylation. These divergent effects establish a critical gap in knowledge surrounding GCGR action. mTOR Complex 2 (mTORC2) is composed of seven proteins, including RICTOR, which dictates substrate binding and allows for targeting of AKTSer473. We utilized a liver specific Rictor knockout mouse (RictorΔLiver) to investigate whether mTORC2 is necessary for insulin-receptor (INSR) and GCGR crosstalk. RictorΔLiver mice were characterized by impaired Akt signaling and glucose intolerance. Intriguingly, RictorΔLiver mice were also resistant to GCGR-stimulated hyperglycemia. Consistent with our prior report, GCGR agonism increased glucose infusion rate and suppressed hepatic glucose production during hyperinsulinemic-euglycemic clamp of control animals. However, these benefits to insulin sensitivity were ablated in RictorΔLiver mice. We observed diminished AKTSer473 and GSK3α/βSer21/9 phosphorylation in RictorΔLiver mice, whereas phosphorylation of AKTThr308 was unaltered in livers from clamped mice. These signaling effects were replicated in primary hepatocytes isolated from RictorΔLiver and littermate control mice, confirming cell autonomous crosstalk between GCGR and INSR pathways. In summary, our study reveals the necessity of RICTOR, and thus mTORC2, in GCGR-mediated enhancement of liver and whole-body insulin action.
Smooth Muscle Insulin Receptor Deletion Causes Voiding Dysfunction: A Mechanism for Diabetic Bladder Dysfunction
Authors: Chen Huan , Wu Ali , Zeidel Mark L. , Yu Weiqun
Published: July 2022

Diabetic bladder dysfunction (DBD) is the most common complication in diabetes mellitus (DM). Myogenic abnormalities are common in DBD, however, the underlying mechanisms leading to these remains unclear. To understand the importance of smooth muscle insulin receptor (IR)-mediated signaling in the pathogenesis of DBD, we conditionally deleted it to achieve either heterozygous (SMIR+/-) or homozygous (SMIR-/-) deletion in smooth muscle cells. Despite impaired glucose and insulin tolerance seen with SMIR-/- mice, both SMIR+/- and SMIR-/- mice exhibited normal blood glucose and plasma insulin levels. Interestingly, these mice had abnormal voiding phenotypes, that included urinary frequency and small voids, and bladder smooth muscle (BSM) had significantly diminished contraction force. Morphology revealed a dilated bladder with thinner BSM layer, and BSM bundles were disorganized with penetrating interstitial tissue. Deletion of IR elevated FoxO and decreased mTOR protein expression, which further decreased the expression of Chrm3, P2x1, Sm22, and Cav1.2, crucial functional proteins for BSM contraction. Furthermore, we determined the expression of adiponectin in BSM, and deletion of IR in BSM inhibited adiponectin-mediated signaling. In summary, disruption of IR-mediated signaling in BSM caused abnormalities in proliferation and differentiation, leading to diminished BSM contractility and a voiding dysfunction phenotype that recapitulates human DBD. 
Drip Irrigation as a Potential Alternative to Traditional Irrigation Method for Saline Water Usage in Vegetable Crops- A Review
Authors:   Dept. of Soil Science, CCS HAU, Hisar, Haryana (125 004), India, - Seema , Dahiya Rita ,   Dept. of Physics, CCS HAU, Hisar, Haryana (125 004), India, Prakash Ram ,   Dept. of Soil Science, CCS HAU, Hisar, Haryana (125 004), India, Sheoran H. S. ,   Dept. of Soil Science, CCS HAU, Hisar, Haryana (125 004), India, - Roohi ,   Regional Research Station, CCS HAU, Hisar, Haryana (125 004), India
Published: July 2022

The aim of this review was to understand the response of various vegetable crops to different salinity and nitrogen levels under drip and traditional methods of irrigation. Effective methods of irrigation water application are important that would allow the proper use of poor-quality water for sustainable production. Drip irrigation is an economically feasible technology for water-saving (40%) and increasing the yield (30−40%) in different crops. Various research studies found that the salt concentration of irrigation water was negatively correlated with growth, fruit yield and quality parameters of vegetable crops. Further, the plants which received 100% of recommended dose of fertigation under saline water irrigation showed a better performance in terms of higher nutrient uptake of nitrogen (150.09−226.26 kg ha-1), phosphorous (13.67−74.64 kg ha-1), and potassium (155.70−302.05 kg ha-1) with highest water use efficiency (11.9−61.68 kg ha-1 m-1). We made an attempt to review and compile the ill effects of saline water application and also summarise management strategies to manage poor quality water in vegetable production, especially in arid and semi-arid regions. The review also highlighted the importance of drip irrigation as an alternative to conventional methods for efficient use of poor-quality water without adversely affecting the quality and productivity of vegetable crops.
Economic Profitability and Carbon Stock Potential of Cereals and Pulses Under Harar and Aonla Based Agroforestry Systems in The Low Hill Zone of Himachal Pradesh
Authors:   College of Forestry, Dr YSP UHF Nauni, Solan, H. P. (173 230) India, Bhatia Avinash Kumar , Sharma Kamal ,   College of Horticulture and Forestry, Dr YSP UHF Neri, Hamirpur, H. P. (177 001) India, Pant K. S. ,   College of Forestry, Dr YSP UHF Nauni, Solan, H. P. (173 230) India, Singh Samanpreet ,   College of Forestry, Dr YSP UHF Nauni, Solan, H. P. (173 230) India, Prakash Prem ,   College of Forestry, Dr YSP UHF Nauni, Solan, H. P. (173 230) India, Kumar Parveen ,   College of Forestry, Dr YSP UHF Nauni, Solan, H. P. (173 230) India, - Saakshi ,   College of Forestry, Dr YSP UHF Nauni, Solan, H. P. (173 230) India, Sharma Harish ,   College of Forestry, Dr YSP UHF Nauni, Solan, H. P. (173 230) India
Published: July 2022

Practicing wheat-maize cropping system by the farmers of Himachal Pradesh is less economical viable as compared to pulses. Besides this, pulses have high potential of soil improvement through nitrogen fixation. Hence, the experiment was premeditated to evaluate the carbon stock potential and economic profitability of cereals and pulses under Harar and Aonla based agroforestry systems in the low hill zone of Himachal Pradesh. The experiment was conducted with nine treatment combinations with four replications in RBD. Highest biomass (77.80 t ha-1) and carbon stock (38.05 t ha-1) were recorded under maize+Harar. In term of economics, maximum gross returns (80,471.49 ` ha-1) were obtained for maize+Aonla yet, the maximum net returns (42,684.40 ` ha-1) and BC ratio (2.14) were found for mash+Aonla.
Contact stress analysis of a spur gear using Lewis and Hertz theory
Authors: Muhammad Aisha , Haruna Shanono Ibrahim
Published: July 2022

The rapid development of the automobile and aircraft industries has made applying gear technology necessary. Gears offer the benefits of efficiency, reliability, simplicity and a higher speed ratio with power transmission. However, they cannot transmit power over a long period, are more expensive when compared to belts and chain drives and requires continuous lubrication. They are used for transmitting high load in gear tools. The gear teeth fail when subjected to a high load beyond a certain limit. A deciding factor in gear design is the amount of stress developed on the contact surface of the mating gears. This paper deals with contact stress analysis of spur gear. The theoretical analysis presented in this paper aims to analyse rolling bearing contacts based on the principles of the Hertz and Lewis equations. A 3D domain-based finite element method was used to calculate the stresses between the contact surfaces of the structure. Contact analysis was performed using ANSYS Workbench software to figure out the deformation and optimum stress developed on the teeth of the gear. The simulation results indicated that the stress distribution on the gear contact surface has a maximum value of 144.82 MPa, while the deformation is at a maximum value of 0.01676 mm. The safety factor indicates the maximum level of 15, indicating the safety of the design.
PENGARUH PENAMBAHAN TEPUNG KOMPOSIT (KACANG MERAH-KACANG KEDELAI) TERHADAP KARAKTERISTIK TORTILLA CHIPS
Authors: Syaiful Friska
Published: July 2022

Tortilla chips merupakan makanan ringan yang menggunakan jagung sebagai bahan dasarnya, tetapi jagung mempunyai kadar protein yang rendah. Salah satu cara untuk meningkatkan kandungan protein pada produk olahan jagung adalah menambahkan bahan pangan yang mengandung protein lebih tinggi seperti tepung komposit dari kacang-kacangan. Tujuan penelitian adalah untuk mempelajari pengaruh penambahan tepung komposit dari kacang merah dan kacang kedelai terhadap karakteristik fisik, kimia, dan sensoris tortilla chips. Penelitian ini menggunakan Rancangan Acak Lengkap. Faktor perlakuan adalah formulasi tepung (tepung jagung : tepung komposit). Parameter yang diamati adalah karakteristik fisik (warna, tekstur), kimia (kadar air, abu, protein), dan sensoris (warna, tekstur, rasa) tortilla chips. Hasil penelitian menunjukkan bahwa formulasi tepung berpengaruh nyata terhadap peningkatan nilai lightness, kadar air, kadar abu, dan kadar protein tortilla chips. Berdasarkan karakteristik sensoris, kadar protein, dan kadar abu, perlakuan terbaik adalah tortilla chips dengan formulasi 60% tepung jagung dan 40% tepung komposit.
EFL Lecturers’ and Students' Perception towards Online Learning in Riau context: Using Technology Acceptance Model (TAM) as the Organizing Framework
Authors: Budiyanti Kurnia , Amelia Riza , Natasha Harum
Published: July 2022

Online learning in the pandemic has been conducted with less preparation by both the teachers and the students. Whether or not it has been effective, little is known. The research aims to conduct research on EFL lecturers’and students’ perception toward online learning from the perspective of technology acceptance model by Davis et al. (1989). The design of the reserch is descriptive quantitative. There were 14 EFL lecturers  and 121 EFL students recruited in the study. Data collection method was a questionnaire with a 5-Likert scale. Data analysis was descriptive statistics. The findings reveal that the lecturers’perceived usefulness and the perceived ease-of-use fall on high category (respectively, 72,95% and 71,1%) and the students’ lecturers’perceived usefulness and the perceived ease-of-use fall on high category (respectively, 79.10% and 72.50%). Out of all items, the lecturers mostly appreciated the flexibility of online learning in term of time and place (82.86%); and the students mostly appreciated the online learning’s opportunity to study English ((77,19%). Some suggestions are given to future researchers, namely (1) the next researcher can recruit more participants, (2) the next researcher can use different instruments to collect the data, like observation, interview and tests. Keywords: online learning, perceived usefulness, perceived ease-of-use, face-to-face.
Preklad voľných a ustálených slovných spojení
Authors: Jakubičková Barbara
Published: July 2022

Corpora are mainly used in translating of parallel texts, i.e., identical texts from two or more languages. Comparative method is used here in terms of comparing language using aspect and cultural aspect as well. Moreover, corpora provide a translator with a wide range of different translation techniques when trying to find the best equivalent that would be appropriately used in a given context. That is why the aim of the article is to analyse the translation of free and fixed word combinations from the English into the Slovak language. The research material used is the Slovak National Corpus. The article will be primarily focused on five chosen adjectival-noun word combinations from the topic of human relationships. Based on the research findings, it can be concluded that not all collocations in the source language are collocations in the target language at the same time. Thus, the context seems to play a very important and decisive role in the process of translating word combinations.
Foam rolling and neurodynamic mobilization: an evaluation of pain perception dynamics among powerlifters
Authors: Buragas Tomas , Razon Selen , Slapšinskaitė-Dackevičienė Agnė
Published: July 2022

Pain and injury are common problems among athletes and recreational powerlifters who perform squats, bench presses and deadlifts. Data suggests that 43.3% of powerlifters experience pain in the course of their workout session. However, little is known with regards to the use of interventions including neurodynamic mobilization and foam rolling for improving the experience of pain among powerlifters. Five female and nine male powerlifters (M age27.14, SD=2.48), with no musculoskeletal injuries in the past 6 months were tested into two groups: 1) foam rolling group (FRG; n=7) and, 2) neurodynamic mobilization group (NMG; n=7). Interventions lasted a total of four weeks for both FRG and NMG. Relative to the subjects in FRG, subjects in NMG reported less pain following the completion of interventions. Regular foam rolling tends to reduce the intensity of moderate pain. However, in contrast to foam rolling, neurodynamic mobilization results in significantly less perception of pain.
Physical activity levels among college students during the pandemic - a narrative review
Authors: Rutkowska Anna , Rutkowski Sebastian
Published: July 2022

The period of the pandemic and government restrictions introduced many changes in health-promoting behaviors among college students. It is known that insufficient levels of physical activity are associated with a number of chronic diseases and mental health disorders. The aim of this study was to provide an overview of the current state of art regarding the level of physical activity during the pandemic among students in Poland, the Czech Republic and Slovakia. Analysis of included studies revealed a decrease in the level of physical activity. Thus, the implementation of education programs to increase physical activity levels to counteract the effects of the pandemic remains crucial.
Implications of Work in the Covid Isolation Ward and the Central Emergency Department on the Life and Work of Nurses
Authors: Pavić Jadranka , Vučko Marija , Liška Franjo
Published: July 2022

Nurses as the largest group of health workers are at the forefront of the health system’s response to the pandemic. in order to control the spread of infection in patients with suspected or confirmed infection, the need for the formation of covid isolation wards was emphasized. The situation required rapid adaptation to new working conditions, which affected the psychophysical condition and professional and private life of nurses who were actively involved in the care of patients with suspected or confirmed SArS-cov-2 infection. The aim of the paper is to identify the most common problems faced by nurses working in covid isolation wards and central emergency departments. based on the obtained results, the biggest problems in working with SArS-cov-2 positive patients were working in 12/24-hour shifts (82%), working in pro- tective clothing (74%) and lack of staff (88%). Also, problems were present due to the frequent reorganization of work and the absence of members of the already experienced team due to illness (76%). Work- ing with SArS-cov-2 suspected/positive patients negatively affected job satisfaction (46%) as well as did frequent isolation from family (58%). research has shown that working with SArS-cov-2 suspected/positive patients has changed the private lives of nurses (74%), and has negatively affected physical health (78%), as well as mental health (70%), of our respondents. despite difficult working conditions, satisfaction was shown with the knowledge and experience of working with highly contagious patients in isolation conditions (64%), strengthened sense of teamwork (66%) and meeting team members who are extremely dedicated and good colleagues (72%).
White Lies: Unraveling Whiteness in the Elementary Art Curriculum
Authors: Link Beth
Published: July 2022

This article presents three case studies of elementary art education curriculum in districts across the United States. The study uses content analysis, which is grounded in Critical Whiteness Studies in order to examine the ways district art curricula address issues of race and whiteness in elementary art education. Findings suggest that district curricula reinforces racial inequities by omitting artists of color, reaffirming racial hierarchies through the master narrative of white progress, and decontextualizing the socio-cultural concerns of non-white artists. The article ends by suggesting reforms in order to create anti-oppressive multicultural art curricula.
Why is it not Just a Joke? Analysis of Internet Memes Associated with Racism and Hidden Ideology of Colorblindness
Authors: Yoon Injeong
Published: July 2022

This article discusses how Internet memes associated with racism can be analyzed and pedagogically utilized through the theoretical frame of Critical Race Theory. The assumption of the study is that Internet memes, as a site of ideological reproduction, can show one aspect of racial discourse. I consider Internet memes regarding race and racial issues as racial humor in this study. I gathered a total of 85 memes addressing or connected to racism primarily from the Memecenter website (www.memecenter.com). In this study, I analyzed their forms and content to consider how these memes deal with racism in different ways. Methodologically, this study implements critical discourse analysis in combination with multimodal discourse analysis. Through this study, I found that the majority of Internet memes about racism perpetuate colorblindness by mocking people of color and denying structural racism. I argue that challenging colorblindness through critical analysis of Internet memes and creating counter- memes will enhance students’ critical awareness of racial issues.
Museum and Art Education as a Response to Place in Doha, Qatar
Authors: Buffington Melanie L. , Bedoyan Maral
Published: July 2022

In this article we address the theme of place through the lens of the significant and recent changes in the nation of Qatar and how a particular museum, Mathaf: Arab Museum of Modern Art, has addressed its geographic location in Doha, Qatar. Through a description of the recent efforts to transform to a knowledge-based economy, focusing on the arts and education in Qatar, we set the stage for how the student art exhibits at Mathaf are responsive to the local area. Through these recent exhibitions, Mathaf is offering opportunities for young people in Qatar to make art in ways that relate to their local context and the rapid changes in the region. Further, by exhibiting student art within the museum galleries, the museum communicates the importance of young people and their art to all Mathaf’s stakeholders.
Editorial Introduction
Authors: Garber Elizabeth
Published: July 2022

Is the Tower of Babel to be understood as a curse upon humankind or as a wealth of diversity? In art and visual culture education, were we to discuss it, the latter interpretation would prevail, for we have a long and deep engagement with valuing diverse cultures and differences among individuals, and working for social and educational change that will promote social justice. This issue of Journal of Cultural Research in Art Education (jCRAE) continues this rich heritage, with articles ranging from empowering youth experiencing disability to a self-examination of teaching multicultural art education to experiences of immigrant women, and from bases in the US, Syria, China, and Taiwan. Each of the authors works for social justice through education, envisioning another step towards social transformation. The authors use field-based methodologies, bringing readers teaching and learning experiences from classrooms, a field school, a gallery, and interviews.
Reflecting on a Paradigm of Solidarity? Moving from niceness to dismantle whiteness in art education
Authors: Dewhurst Marit
Published: July 2022

This essay uses personal reflections interwoven with critical analyses of whiteness to explore how whiteness is upheld and perpetuated in art education. Through a discussion of the pervasiveness of white-centered cultural values that maintain the power of white ways of being, the author argues that the field must seek different values and practices. Drawing on the work of several anti-racism educators, this essay highlights several values and practices that, if embraced, might move the field of art education towards a paradigm of solidarity.
Reevaluating Middle Eastern Contributions to the Built Environment in Europe
Authors: Drab Theodore , Bozorgi Khosrow
Published: July 2022

An exploration of the examination of Middle Eastern contributions to European architecture, interior design and decorative arts in historical survey texts reveals a prejudicial marginalization of the impact of the former on the latter culture. Western scholars’ nationalistic efforts to build up the stature of their cultures’ achievements have almost invariably resulted in discounting those of other cultures. Although designers of buildings might be more prone to share Bannisters Fletcher’s idea of architecture as the art form that is “more than any other national product”, students and teachers of all the arts should recognize and neutralize the impact of nationalism on art history and criticism.
Critical Mass[es]: Reflections on the Flag Project as Activist Art
Authors: Desai Dipti , Bui Thu , Filippo Lisa Di
Published: July 2022

This is a report on a peace project done at New York University, following the events of 9/11. The authors set their discussion into the framework of activist art and describe the social as well as artistic outcomes of their project.
A model of transient laryngeal hemiplegia in dogs through conduction blockade of the recurrent laryngeal nerve
Authors: Martin-Flores Manuel , Sakai Daniel M. , Campoy Luis , Cheetham Jonathan
Published: July 2022

OBJECTIVE

To create a model of transient unilateral laryngeal paralysis (LP) that will allow the study of cricoarytenoideus dorsalis dysfunction and a method for quantification of varying degrees of LP in dogs.

ANIMALS

5 castrated male research Beagles.

PROCEDURES

Between January and February 2018, dogs were anesthetized and instrumented with a laryngeal mask airway and a flexible endoscope to record the rima glottidis. The left or right recurrent laryngeal nerve (RLn) was localized using ultrasonography and electrical stimulation, then conduction blockade was induced with perineural lidocaine. The normalized glottal gap area (NGGA) was measured before and every 15 minutes after the block. Inspired 10% carbon dioxide (CO2) was administered for 1 minute at each sampling time. The inspiratory increase in NGGA (total and each side) was measured at peak inspiration. The change in hemi-NGGA for the control side versus the anesthetized side was evaluated with a mixed-effect model.

RESULTS

During CO2 stimulation, the increase in inspiratory hemi-NGGA was consistently less (P < .001) for the treated side (–8% to 13%) versus the control side (49% to 82%). A compensatory increase (larger than at baseline) in the control hemi-NGGA was observed. The total NGGA remained unaffected.

CLINICAL RELEVANCE

Unilateral local anesthesia of the RLn produced transient unilateral LP with a compensatory increase in the hemi-NGGA for the contralateral side. This model could facilitate the evaluation of respiratory dynamics, establishment of a grading system, and collection of other important information that is otherwise difficult to obtain in dogs with LP.
Veterinarians should understand what it means to use conditionally approved drugs, with a focus on conditional approval of companion animal oncology drugs
Authors: Loss Christopher M.
Published: July 2022

The purpose of this article is to provide veterinarians with an understanding of what it means to use a conditionally approved drug. This article summarizes information that has been used to satisfy the reasonable expectation of effectiveness (RXE) standard for conditionally approved companion animal oncology drugs and compares that standard to the substantial evidence of effectiveness (SEE) standard. For conditional approval, the drug company must establish a RXE but need not demonstrate SEE. For a full approval (ie, New Animal Drug Application), the drug company must demonstrate SEE. Information to support a RXE for conditional approval of companion animal oncology drugs has included open-label pilot studies, retrospective analysis of medical records, use of a related formulation, and clinical field studies not meeting their primary effectiveness variable. Oncology drugs are highlighted in this article as they have made up many of the conditionally approved drugs to date. Veterinarians should understand that a conditionally approved drug does not have the same assurance of effectiveness as a drug receiving full approval. However, whether conditionally or fully approved, the drug has been demonstrated to be safe for the intended use. This report did not undergo scientific peer review.
A global one health perspective on leptospirosis in humans and animals
Authors: Sykes Jane E. , Haake David A. , Gamage Chandika D. , Mills W. Zach , Nally Jarlath E.
Published: July 2022

Leptospirosis is a quintessential one health disease of humans and animals caused by pathogenic spirochetes of the genus Leptospira. Intra- and interspecies transmission is dependent on 1) reservoir host animals in which organisms replicate and are shed in urine over long periods of time, 2) the persistence of spirochetes in the environment, and 3) subsequent human-animal-environmental interactions. The combination of increased flooding events due to climate change, changes in human-animal-environmental interactions as a result of the pandemic that favor a rise in the incidence of leptospirosis, and under-recognition of leptospirosis because of nonspecific clinical signs and severe signs that resemble COVID-19 represents a “perfect storm” for resurgence of leptospirosis in people and domestic animals. Although often considered a disease that occurs in warm, humid climates with high annual rainfall, pathogenic Leptospira spp have recently been associated with disease in animals and humans that reside in semiarid regions like the southwestern US and have impacted humans that have a wide spectrum of socioeconomic backgrounds. Therefore, it is critical that physicians, veterinarians, and public health experts maintain a high index of suspicion for the disease regardless of geographic and socioeconomic circumstances and work together to understand outbreaks and implement appropriate control measures. Over the last decade, major strides have been made in our understanding of the disease because of improvements in diagnostic tests, molecular epidemiologic tools, educational efforts on preventive measures, and vaccines. These novel approaches are highlighted in the companion Currents in One Health by Sykes et al, AJVR, September 2022.
The Selection of “Green” Conditions for Components Identification in a Combined Medicine by TLC/HPTLC Methods
Authors: Rudakova Olha V. , Gubar Svitlana M. , Smielova Nataliia M. , Kriukova Anna I. , Bevz Nataliia Yu. , Georgiyants Victoriya A.
Published: July 2022

Aim. To select “green conditions” for identifying components in a combined medicine for the treatment of alcohol intoxication.Materials and methods. Thin-layer chromatography and high performance thin-layer chromatography methods were used. An analytical GREEnness calculator was applied to assess the environmental friendliness of the analytical procedure.Results and discussion. The choice of mobile and stationary phases that comply with the principles of “green chemistry” and can be used to detect glutamic acid and glycine in the composition of a combined medicine has been substantiated. It has been determined that by the indicators Rf, Rs, ΔRf, α, N, H the most effective for the division is the ethanol (96 per cent) – water (70:30) mobile phase (the length of the solvent front is 10 cm, the application volume is 5 μL), which allows, in addition to amino acids, to determine another prescription component – ascorbic acid. The conditions for identification of substances by the high-performance thin-layer chromatography method (the length of the solvent front is 7 cm, the application volume is 2 μL) have been selected. It has been found that to detect chromatographic zones, it is optimal to use ninhydrin solution R1 with further heating of the plate at a temperature of 100-105°С for 5 min. The specificity of determination of glutamic acid, glycine and ascorbic acid in comparison with solutions of standard substances has been proven. While studying the robustness of the method the influence of chromatographic conditions on the final result (the impact of the stationary phase type, chamber saturation, application volume, distance from the “start line” to the “finish line”, the effect of the detection solution, stability of solutions for application) has been researched. The precision of the method on one and three plates of the same type has been studied; the intermediate precision has been researched. The calculated assessment of greenness of the analytical procedure is 0.66.Conclusions. As a result of the studies conducted, “green conditions” for identifying amino acids (glutamic acid, glycine), as well as ascorbic acid in a combined medicine by thin-layer chromatography and high-performance thin-layer chromatography methods have been selected. The validation characteristics of the method (specificity, robustness and precision) have been studied.
Maliyet Kontrolü Açısından Tıbbı Malzemelerin Standart Maliyet Yöntemine Göre Varyans Analizi ve Muhasebeleştirilmesi: Düzce Üniversite Hastanesinde Bir Uygulama
Authors: ÇİVİ Figen , BOZDEMİR Enver
Published: July 2022

Çalışmanın amacı, Düzce Üniversitesi Hastanesi Kardiyoloji, Göğüs Hastalıkları ve Çocuk Sağlığı ve Hastalıkları birimlerinde kullanılan tıbbi ve tıbbi olmayan malzemelerin standart maliyet yöntemine göre sapma analizini yaparak maliyetlerin kontrolü açısından hastane yönetimine faydalı bilgiler sunmaktır. Nitel bir araştırma olan bu çalışmanın verileri 2018 yılını kapsamakta olup hastane bilgi sistemi, yüz yüze görüşme, uzman görüşü, mutemetlik, Döner Sermaye İşletme Müdürlüğü ve hastane kayıtlarından yararlanılarak doküman incelemesiyle elde edilmiştir. Çalışmanın evreni Düzce Üniversitesi Sağlık Uygulama ve Araştırma Merkezi (Hastanesi-DÜSUAH)’nin tüm klinik birimleri oluştururken örneklemi hastanenin Kardiyoloji, Göğüs Hastalıkları ve Çocuk Sağlığı ve Hastalıkları birimlerinden oluşmaktadır. Yapılan araştırmada Kardiyoloji birimine ait -2.560,00 TL’lik olumsuz bir sapma olduğu bunun -12.775,00 TL tutarı olumsuz fiyat farkından, 10.215,00 TL’nin ise olumlu miktar farkından kaynaklandığı tespit edilmiştir. Çocuk Sağlığı ve Hastalıkları birimine ait -972,33 TL’lik bir olumsuz sapma olduğu bunun -2.810,33 TL’lik kısmı olumsuz fiyat farkından, 1.838,00 TL’lik kısmı ise olumlu miktar sapmasından kaynaklandığı tespit edilmiştir. Göğüs Hastalıkları birimine ait 19.220,46 TL’lik olumlu bir sapmanın olduğu bunun 27.209,46 TL’lik kısmı olumlu fiyat farkından, -7.989,00 TL’lik kısmı ise olumsuz miktar farkından kaynakladığı görülmüştür. İlgili birimlerde toplam sapmanın 15.688,13 TL olumlu olduğu analiz edilmiştir. Elde edilen bulgulara göre olumlu fiyat sapmalarının rekabetçi ortamda ihale işlemelerinin yapılmasından, olumsuz fiyat sapmalarının ise hastanenin vadeli alımlardan kaynaklandığı tespit edilmiştir. Olumsuz miktar sapmaları, kalitesiz malzeme satın alınması ve kullanım esansındaki dikkatsizliklerden, olumlu miktar sapmaları ise yeterince stok sayım ve kontrolünün yapılmamasından kaynaklandığı görülmüştür. Yapılan çalışmada ilk madde ve malzemelerde maliyetlerin kontrolü açısından standart maliyet yönteminin hastane işletmelerinde de kullanılabileceği tespit edilmiştir.
Hanehalklarının Harcamalarını Etkileyen Faktörler: Türkiye Üzerine Mikroekonometrik Bir Çalışma
Authors: ÇEBİ KARAASLAN Kübranur
Published: July 2022

Kamu politikalarının önemli bir bileşeni olan hanehalkı harcamaları, bireysel ve dolayısıyla toplumsal refahın göstergesidir. Hanehalkı tüketim harcamalarını etkileyen faktörleri bilmek kamu politikaları başta olmak üzere birçok açıdan fayda sağlayacaktır. Bu motivasyon kaynağı ile çalışmanın amacı hanehalklarının tüketim harcamaları belirleyicilerini mikroekonometrik bir bakış açısıyla incelemektir. Bu amaç doğrultusunda çalışmanın veri seti Türkiye İstatistik Kurumu Hanehalkı Bütçe Anketi aracılığıyla elde edilmiştir ve veri setinin analizi için bağımlı değişkenin dağılımının birçok noktasında bilgi edinilmesine imkân sunan kantil regresyon kullanılmıştır. Çalışma sonucunda hane sorumlusunun cinsiyetinin, yaşının, medeni durumunun, eğitim durumunun, hanehalkı büyüklüğü, gelir başta olmak üzere ekonomik göstergelerin ve sosyal göstergelerin tüketim harcamaları üzerinde etkili olduğu tespit edilmiştir. Çalışmanın sonuçlarını, araştırmacı ve politika yapıcıların yaşam standartlarını ve refahı iyileştirmeyi amaçlayan faaliyetleri başta olmak üzere gelecekteki politikaların formüle edilmesinde faydalı olması beklenmektedir.
Öznel İktisadi İyi Oluş ve Öznel Sağlık Algılarının Belirleyicileri: İki Değişkenli Sıralı Probit Yaklaşımı
Authors: UĞUR Mehmet Sedat , SİGEZE Çiler
Published: July 2022

Bu çalışmanın amacı Türkiye’deki hanehalklarının öznel iktisadi iyi oluş ile öznel sağlık algılarının belirleyicilerini, bu iki öznel bilgi arasındaki etkileşim dikkate alarak incelemektir. Bu çerçevede, Türkiye İstatistik Kurumu (TÜİK) tarafından yayımlanan 2017 yılı Gelir ve Yaşam Koşulları Araştırması (GYKA) mikro veri setinden yararlanılmıştır. Bu veri setindeki, “hanenin toplam geliri ile gerekli harcamaları yapabilme durumu” sorusuna verilen yanıtlar “öznel iktisadi iyi oluş” ve “hanehalkı reisinin sağlık durumu” sorusuna verilen yanıtlar ise “öznel sağlık” olarak tanımlanmıştır ve bu değişkenler çalışmanın bağımlı değişkenlerini oluşturmaktadır. Çalışmada, hanehalkı reisinin iyi-oluşunu etkileyen bağımsız değişkenlerin incelenmesinde, bağımlı değişkenin sıralı yapısını ve iki bağımlı değişken arasındaki etkileşimi dikkate alan iki değişkenli sıralı probit model kullanılmıştır. Çalışmadan elde edilen bulgulara göre hanehalkı reisinin eğitim düzeyi arttıkça, hanehalkı reisinin öznel sağlık algısı daha iyi olmaktadır. Bunun yanında hanehalkı reisinin işsiz veya boşanmış olması, öznel iktisadi iyi oluşunu ise olumsuz etkilemektedir. Hanehalkı geliri ise hem hanehalkı reisinin öznel iktisadi iyi oluşunu hem de öznel sağlığını etkileyen en önemli değişkendir. Sonuç olarak hanehalkı reisinin öznel iktisadi iyi oluşu ve öznel sağlığının belirleyicileri farklılık göstermekle birlikte iki öznel bilgi arasında ilişki söz konusudur.
Mediation Regulations Re-Arrangement’s Efforts at the State Court Based on Confidential Principles as the Parties’s Protection
Authors: Sinaga Rika Destiny , Emirzon Joni , Syaifuddin Muhammad
Published: July 2022

Mediation is characterized by confidentiality principle that protects the reputations of the disputing parties. However, the implementation of mediation in district courts is affected by the principle of public trial, leading to significant challenges. This paper examines two key questions: how do confidentiality-based mediation arrangements in district courts safeguard the reputations of the parties involved, and what reforms are necessary to ensure that these arrangements effectively uphold confidentiality in the resolution of civil cases? Utilizing normative legal research, this study analyzes primary, secondary, and tertiary legal materials collected through document studies. The analysis employs descriptive, comparative, evaluative, and argumentative techniques. The findings indicate that while mediation procedures in courts are governed by Supreme Court Regulation Number 02 of 2003 and subsequently by Supreme Court Regulation Number 01 of 2008, the most recent Supreme Court Regulation Number 1 of 2016 addresses the confidentiality principle but does not fully enforce it. Therefore, there is a pressing need for regulatory reforms, including the unification of mediation laws and a comprehensive revision of civil procedural law. It is crucial for the House of Representatives and the government to establish a dedicated law that regulates mediation, providing a solid legal foundation for its application in both judicial and extrajudicial contexts.
Audit Board of Indonesia’s Supervision Duty Reviewed from Islamic Law Perspective for Acceleration of Sustainable Development
Authors: Taher Palmawati , Bs Dwi Andayani , Fadhlillah Muhammad Rizqi
Published: July 2022

This paper examines the State Financial Auditing Board (BPK) of Indonesia and its parallels with the Mazhalim Region, an institution in Islamic state administration focused on safeguarding state property. Both entities share the fundamental principle of protecting wealth from excessive ambition or greed, emphasizing the Islamic concept of amar ma’ruf nahi munkaras a guiding principle for achieving a balanced life. The study explores the BPK's role in accelerating sustainable development within the framework of Islamic governance, highlighting the significance of its supervisory functions. By conceptualizing law as a social norm that governs behavior, this research focuses on compiling positive law, principles, and doctrines, as well as exploring legal discovery in concrete cases, systematic law, synchronization, legal comparisons, and legal history. Ultimately, this normative legal research seeks to provide insights into the intersection of financial auditing and Islamic principles of governance.
Imposition of Tax Law on Cryptocurrencies and NFT in Indonesia
Authors: Sitompul Anggia Debora
Published: July 2022

This research investigates the potential for government revenue through taxation of digital currencies, commonly known as cryptocurrencies, and digital assets such as NFTs. Employing a normative research methodology, the study analyzes the appropriate tax rates for cryptocurrencies and NFTs and examines existing taxation policies. Additionally, the research explores how different countries regulate and tax these digital assets, revealing a lack of consensus on their legal status and regulatory frameworks. The findings aim to provide insights into how varying tax policies impact revenue generation and offer recommendations for developing effective tax regulations.
THE EFFECT OF GREEN COMPETITIVE ADVANTAGE AND SUPPLY CHAIN MANAGEMENT ON COMPANY PERFORMANCE WITH GREEN HUMAN CAPITAL AS A MODERATING VARIABLE
Authors: Nurdiana Diah
Published: July 2022

This research aims to determine whether there is an impact of green competitive advantage in supply chain management with green human capital as the moderating variable on company performance. In this study, the dependent variable used is company performance (Y), the independent variables are green competitive advantage and supply management (X), and the moderating variable is green human capital. Is this study, a non-probability sampling method was used. 50 textile companies in Jakarta were gathered as sample using non-probability sampling. Primary data was colleted by distributing closed questionnaires. The results of the study be seen through the determination coefficient of Ta given in Table Ta. The R-Square value of the company performance variable is 0.919, which shows that the dependent variable (Company Performance) can be explained by 91.9% of the independent variables (Green Competitive Advantage, Supply Chain Management, Green Human Capital) while the remaining 8.1% cannot be explained.
O ENSINO EM BOTÂNICA NA ÓPTICA DE BIÓLOGOS LICENCIADOS: POSSIBILIDADES E DESAFIOS
Authors: Oliveira Bianca Kussler de , Nobre Suelen Bomfim
Published: July 2022

Atualmente, o ensino de Botânica ainda encontra obstáculos no processo educativo em Biologia. Estudos evidenciam que, muitas vezes, o Ensino Superior não proporciona vivências que possibilitem a experienciação de estratégias para a construção do conhecimento botânico. Neste cenário, o objetivo deste estudo foi analisar as intervenções pedagógicas que envolvem o conhecimento botânico na Educação Básica, a partir da percepção de docentes de Ciências/Biologia, identificando como se desenvolvem os processos de ensino e aprendizagem nesta área do conhecimento. Para atingir este objetivo, optou-se, nesta pesquisa, pelo método qualitativo – exploratório. Foi realizada uma entrevista com oito docentes da Educação Básica no município de Sapiranga/RS, no período de julho a outubro de 2019. A avaliação dos dados consolidou-se através da análise de conteúdo e uso do software Iramuteq. Os resultados obtidos corroboram com a literatura especializada no que se refere à falta de preparo didático para abordar as temáticas botânicas. Além disso, as entrevistadas sinalizam dificuldades em tematizar os conceitos relacionados à fisiologia vegetal, Plantas Alimentícias Não Convencionais (PANCs), vegetais transgênicos, vegetais híbridos e fitohormônios. Entre as estratégias de ensino adotadas estão: o uso de imagens, vídeos e aulas práticas experimentais. Constatou-se que é preciso que a Botânica seja apresentada de forma contextualizada, em todos os níveis de ensino, para que os discentes consigam perceber a importância dos vegetais e que eles se fazem presentes de forma integral em nossas vidas.
Dependencia, tercermundismo y modernización económica. Claves para repensar la historia del Chile controvertido de hoy (1810-2022)
Authors: Álvarez Sepúlveda Humberto
Published: July 2022

Este artículo examina el tercermundismo del Chile actual incentivado por la dependencia exterior que ha estado presente en sus tres grandes planes de modernización (el modelo primario exportador 1810-1930, la adopción del proyecto económico ISI 1930-1973 y el creciente auge del experimento neoliberal chileno 1973-2022). La metodología base fue la revisión bibliográfica, crítica y documental, pues se utilizó el método descriptivo-argumentativo para analizar la temática prevista. La información fue recogida mediante la indagación de fuentes extraídas de las siguientes bases de datos: Redalyc, Clacso, Scopus, Wos, Scielo, ProQuest, Dialnet y Latindex. Producto de esta investigación, el trabajo adopta la idea de que el subdesarrollo chileno es resultado del desfase suscitado entre la dependencia exterior impulsada desde las élites vinculadas al libre mercado y la promoción de un plan de desarrollo nacional, proceso en que ambas disyuntivas están determinadas por dinámicas históricas complementarias e interdependientes. A partir de este planteamiento, se analizan las principales contradicciones políticas, económicas y sociales que se han gestado a lo largo de las tres grandes reformas a objeto de reflexionar sobre la posición tercermundista del país, postura que debate, por lo demás, la categoría de “milagro económico” que se ha publicitado para Chile desde la dictadura de Augusto Pinochet.
Aberrant antigenic expression in acute leukemia: Study from a tertiary care center in Southern India
Authors: Hajra Subhajit , Panduragan Sathya , Manivannan Prabhu , Kar Rakhee , Basu Debdatta
Published: July 2022

Objectives:

Aberrant antigenic expression in acute leukaemia is an expression of antigens which is not normally associated with acute leukaemia of that specific lineage and does not fulfil the criteria for diagnosis of Mixed phenotype acute leukaemia (MPAL). This aberrant immunophenotype can be used for the assessment of measurable residual disease (MRD) and sometimes may predict certain genetic events.

Material and Methods:

This was a cross-sectional study conducted in a tertiary care centre in Southern India over two years to assess the type and frequency of aberrant antigen expression in acute leukaemia by multiparameter flow cytometry. All routine cases of acute leukaemia confirmed by flow cytometric immunophenotyping were enrolled.

Results:

Among 244 acute leukemia cases, 84 (34%) B-ALL, 28 (11%) T-ALL, 124 (51%) AML and 8 (3%) MPAL were found. Aberrant antigenic expression was seen in 17 (20%) B-ALL, 5 (18%) T-ALL, 33 (27%) AML and 1(12.5%) MPAL. Most common aberrancy in AML was CD7(70.3%) followed by CD19 (13.5%) and CD79a (10.8%), in B-ALL was CD33(52.6%) followed by CD13 (10.5%) and CRLF2 (10.5%) and in T-ALL were CD33 and CD 79a (40% each).

Conclusion:

B-ALL showed a greater heterogeneity in aberrant antigens compared to AML and T-ALL. The future implication of this study is that aberrant markers can help in monitoring measurable residual disease Some aberrant phenotypes may indicate the presence of a genetic event or may be of prognostic significance. Some aberrant antigens may also be used as therapeutic targets.
The place and role of leisure in the Moscow students’ everyday life in the context of the information society development
Authors: Nadekhina Yu. P. , Kolchin A. A. , Kryukova E. V.
Published: July 2022

The proposed article discusses issues related to the daily life of Moscow students and their leisure, the relevance of which in the context of the development of the information society is associated with increased attention of the state to the educational component of modern educational systems. Moreover, in the conditions of modern realities of the development of the information society, and, consequently, information culture, the format of leisure becomes a significant factor in the socialisation of the individual.

   As a goal, the authors of the article identified the analysis of various forms of leisure activities of Moscow students through their questionnaires, which was designed to outline vectors for further research of the place and role of study, family relations and forms of spending free time in a student’s life.

   Special attention is paid to modern forms of leisure for students, such as: spending time on the Internet, visiting experimental theaters and cinemas, watching talk shows and entertainment programs, visiting immersive shows, participating in modern youth organisations, etc. Summarising the results of the study, it was concluded that at the moment no more than 20 % of the surveyed Moscow students choose “modern” forms of leisure activities. The conducted research revealed the students’ clear preferences in spending their free time, as well as their value orientations.
A FAIR approach for detecting and sharing PFAS hot-spot areas and water systems
Authors: Ojha Sweta , Thompson P. Travis , Powell Christian D. , Moseley Hunter N.B. , Pennell Kelly G.
Published: July 2022

Per- and polyfluoroalkyl substances (PFAS) contamination in water sources near potential PFAS users is well known. Therefore, it is useful for PFAS stakeholders to visualize hot-spot areas and bring attention to the water systems that are near to those areas. Towards this end, we extracted information about PFAS sources, drinking water information, sewer water information, and Source Water Assessment Protection Program (SWAPP) information from publicly available sources to create five different maps in ArcGIS Online that highlight PFAS contamination in relation to potential PFAS users. Following the FAIR (Findable, Accessible, Interoperable and Reusable) principles, we created a Figshare repository that includes all data and associated metadata with these five ArcGIS maps. Moreover, the Figshare repository includes a metadata description of the maps in JSON format that adheres to a draft Minimum Information about Geospatial Information System (MIAGIS) standard we have developed. We hope this MIAGIS draft will assist in establishing a GIS standards group that will develop the draft into a full standard for the wider GIS community. We have also developed a miagis Python package that facilitates the generation of a MIAGIS-compliant JSON metadata file.