bluuebunny/crossref_metadata_2025 huggingface dataset:
INTEGRATION NORMS IN THE FIELD OF MIGRATION: CONCEPT AND SIGNIFICANCE FOR THE DEVELOPMENT OF MIGRATION LAW OF THE RUSSIAN FEDERATION
Authors:   Krasnodar University of the Ministry of Internal Affairs of Russia, ZHEREBTSOV A.V.
Published: November 2024

The purpose of this study is to study the concept and significance of integration norms in the field of migration and their impact on the development of Russian migration law as a sub-branch of administrative law, there is a lack of development of the concept of integration norms and forms of their objectification.As a result of the study, it was revealed that integration norms have a set of specific features that distinguish them from the norms of international and national law, which is due to the very legal nature of their occurrence and the role that they play in achieving the goals of the integration association, which is the Eurasian Economic Union. Conclusion: as a result of the study, a definition of the integration norm was formulated, integration norms in the field of external labor migration of workers of the Eurasian Economic Union member states were considered, their subinstitutional place in the system of Russian migration law was recognized.
THEORY AND PRACTICE OF COLLECTING A COURT PENALTY (ASTRENT) IN CIVIL PROCEEDINGS
Authors:   Kuban State University, KONOREZOV N.A.
Published: November 2024

The purpose of the article is to analyze the theoretical provisions and features of the practical application of the astrent institute (judicial penalty) in civil proceedings. Based on the analysis of the positions existing in the scientific literature, the mixed legal nature of astrent, which is a complex material and procedural institution, is emphasized.The author, taking into account the analyzed judicial practice, concludes that the court penalty is in demand and suggests expanding the scope of its application, including labor and administrative disputes. Taking into account the lack of an unambiguous approach in judicial practice to determining the amount of the astrent, the need for additional specification of the criteria for its determination is emphasized.
THE PULSE OF THE CITY: 'GOUARIR' STREET AND THE EVOLUTION OF PUBLIC SPACES IN ALGERIA
Authors: Farida Sehili
Published: November 2024

The transformation of a neighborhood street into a city-wide street reflects the adaptation of urban forms to new usages, evolving as a space of urbanity where animation and social activity develop. Often located on the public domain, the street differs from the layout of plots, which is constantly changing, its underground infrastructure transforming as networks evolve. In this regard, the concept of the street needs to be assessed in light of the transformations induced by the new urban trends in Algeria. The study of the various urban and architectural transformations of “rue Gouarir” in Bordj Bou Arreridj and its evolution enables us to examine both urban recompositions as an expression of changing patterns of life, and the significance of place in contemporary Algerian cities. This study, conducted from an interdisciplinary perspective involving architecture, urban planning and economics. The aim is to assess the urban transformations and dynamics affecting this street and the people who live on it and build it. In order to better understand the dynamics of street transformation into public space, an analytical method mainly founded on socio-spatial investigation was employed. As a result, “Rue Gouarir” is overseen by community residents and business proprietors, with a conspicuous lack of involvement from local authorities. The interactions within “Rue Gouarir” have substantially transformed the surrounding area, propelling it to become a sought-after and attractive district within the city.
Comparative clinical and laboratory evaluation of the effectiveness of a nanodispersed silica-based drug with antimicrobial properties for the local treatment of purulent inflammatory diseases of the maxillofacial area
Authors: Belyaev P , Shtatko O , Viltsanyuk O
Published: November 2024

Background. The problem of purulent inflammatory diseases of the maxillofacial area remains one of the most pressing problems of modern dentistry and maxillofacial surgery. The aim of the study is to conduct a comparative evaluation of the effectiveness of a drug based on nanodispersed silica (NDS) with antimicrobial properties for the local treatment of purulent inflammatory diseases of the maxillofacial area.
Materials and methods. A comparative assessment of the postoperative period was performed in 71 patients with maxillofacial phlegmon, who were divided into two representative groups: comparison (39 patients), in whose local treatment of purulent wounds was carried out by conventional methods, and the main group (32 patients), where the local treatment was carried out using a drug based on NDC. The level of endogenous intoxication was determined by the level of C-reactive protein (CRP), by the level of blood metabolites of average mass (MAM) and leukocyte intoxication index (LII) in the blood serum. The data obtained were statistically processed and compared.
Results. During the study of the dynamics of СRР was found that starting from 3 days in the main group there was a tendency to its faster decrease and normalization before discharge, while in patients of the comparison group it was significantly higher (p < 0.05)., The level of MAM in patients of the comparison group remained significantly (p < 0.05) elevated throughout the treatment in the postoperative period, while in the main group it was on the verge of normal before discharge. Comparison group of patients had significantly higher LII during treatment and at the time of discharge from hospital (p < 0.05) than the main group.
Conclusions: The treatment of maxillofacial phlegmon by the developed method provided a more favorable course of the postoperative period than in the comparison group, as evidenced by a significantly (p < 0.05) faster normalization of endogenous intoxication blood parameters.
The path to individualization of infusion therapy for emergency conditions according to the ROSE concept
Authors: Dzyuba D , Nedashkivska S
Published: November 2024

The article is devoted to the role of intravenous fluid therapy in conditions of impaired fluid homeostasis, which often occur during major surgical interventions and critical conditions, such as sepsis and trauma. The importance of adequate fluid administration to maintain cellular homeostasis, as well as the management of conditions associated with hypovolemia and hemodynamic disturbances, is described. It is noted that, despite numerous studies, the topic of optimal fluid management strategies remains controversial, with potential risks of adverse effects of excessive fluid administration on clinical outcomes.
The concept of liquid resuscitation ROSE is presented, which includes four stages: resuscitation, optimization, stabilization and evacuation. This concept will assist physicians in making decisions about fluid therapy management. Different types of fluids are reviewed, including balanced solutions and the multifunctional hyperosmolar solution Reosorbilact, and the importance of individualizing therapy based on the needs of each patient is emphasized. The importance of the need for careful monitoring and control of fluid balance is emphasized to avoid complications and ensure improved clinical outcomes
Antibiotic resistance: current challenges and ways of their solution
Authors: Viltsaniuk O , Syvak V , Vovk Y , Bondar L , Taraniuk K
Published: November 2024

The use of antibiotics in various spheres of human life and in various sectors of society has led to the emergence of antibiotic resistance. Pandemics and military conflicts around the world, including in Ukraine, also leave their mark on the evolution of pathogens and their antibiotic resistance, which is associated with the limitation of people’s health needs by the lack of adequate medical care, large-scale migration and uncontrolled use of antibiotics. This article discusses the main actions of microorganisms aimed at protecting themselves from antibiotics, depending on their species. A number of publications have been analyzed to study and highlight the main necessary steps proposed by various authors to overcome this problem both in the healthcare sector and in society.
Reflexiones sobre la función social y educativa del arte
Authors: Sánchez Usón María José
Published: November 2024

Introducción: El arte se sitúa fuera de toda utilidad y propósito concreto, operando desde una existencia que simplemente “es”. A partir de esta premisa, el texto busca diferenciar cómo los procesos imaginativos y creativos, generados sin intencionalidad inicial, adquieren posteriormente una misión “salvífica” con implicaciones sociales y educativas, influida por la percepción histórica de los diferentes grupos humanos. Metodología: La aproximación es interdisciplinar, combinando la reflexión estético-crítica, el análisis y síntesis sociohistórica, y tentativas educativas empíricas. Discusión: Se analiza cómo el arte, en su abstracción, trasciende intentos de concreción. No obstante, las obras individuales permiten vislumbrar la concepción primordial del arte y sus transformaciones a lo largo de la historia. Resultados y Conclusiones: El arte permite al ser humano conocerse a sí mismo, comprender al otro, y preservar valores como la coherencia y la alegría de vivir, promoviendo la integración de lo nuevo y el rechazo de lo obsoleto o dañino para la estabilidad social y personal.
The Zeitenwende and the Nazi Sources of Russian Actions
Authors: Eltsov Peter
Published: November 2024

Before the full-scale invasion of Ukraine by Russia on February 24, 2022, Vladimir Putin had hoped that Germany would stay militarily neutral, counting on Germany's politicians, who had previously expressed understanding for Russia's belligerent actions. Putin did not expect a tectonic change in Germany's foreign and defense policy initiated by the government of Olaf Scholz in response to his war on Ukraine (Zeitenwende). Meanwhile, the Kremlin borrows directly from Nazism in the theoretical justification of its actions, especially from two German scholars: Carl Schmitt and Karl Haushofer.
Germany's Zeitenwende
Authors: Larres Klaus
Published: November 2024

After reviewing the pacifist tradition of German foreign policy, this article explores the shock of the Russian unleashing of a war on European soil. The article then proceeds to explain the various dimensions of German support for Ukraine, especially in increased military spending and energy uncoupling from Moscow. While conceding that German help often arrived slowly, the article nonetheless depicts the dramatic shift in German policy, which has ushered in a new period in defending democracy with military force.
Revising Ostpolitik
Authors: Lemke Christiane
Published: November 2024

The Russian invasion of Ukraine marks a turning point in European security policy. Defense concepts have been altered within Europe as well as in the North Atlantic Treaty Organization (NATO), and Russia is no longer seen as a European partner, but a threat to security and stability in Europe. The article argues that the term Zeitenwende coined by the German chancellor is not a rhetorical figure; rather, it is reshaping Germany's approach to the East and upended German and European Ostpolitik. In fact, the new foreign policy direction sheds illusions of both the classic Ostpolitik of the Cold War and the new Ostpolitik of post-unification Germany by introducing a fundamentally different approach to Eastern and Central Eastern Europe and within NATO. The article explores the critical juncture created by the Zeitenwende of 2022 and its implications for European security policy.
The Zeitenwende, State Traditions, and the Developmental Imperative in German Energy Policy
Authors: Vail Mark I.
Published: November 2024

This article argues that contemporary German environmental and energy policy has been shaped by the dominance of the Rechtsstaat—or “Legal State”—tradition. Although German authorities have articulated laudable climate goals and related hopes for greater energy independence—most recently in Chancellor Olaf Scholz's 2022 declaration of a Zeitenwende in German security and energy policy—the weakness of the developmental imperative, coupled with the power of interests central to the country's export-led growth model, have undermined the investments required for achieving these aims.
Realpolitik Returns to Berlin
Authors: Moroff Holger
Published: November 2024

“Never again” has been a mantra of German foreign policy since the end of World War II. Together with Ostpolitik it informs its approach toward the conflict in Ukraine. The discourse moved from “never again war originating from German soil” via justifying military interventions to prevent ethnic cleansing in the Balkans in 1998 with Joshka Fischer's injunction of “never again Auschwitz” to Olaf Scholz’ programmatic 2023 speech invoking “never again war of aggression in Europe.” This development is interpreted in the light of Realpolitik, providing the hard security means to defend the rule of law and democratic governance. External shocks have led Germany to expand its soft security arsenal as a civilian power and to embrace military means for liberal ends.
Теоретические основы исследования влияния античной риторики на христианскую проповедь IV века
Authors: Георгиевич Ходасевич Сергей
Published: November 2024

В статье рассматриваются теоретические исследования, посвященные античной риторике и христианской гомилии, изучение которых может способствовать научным изысканиям в области влияния античной риторики на христианскую проповедь IV века. В обзор включены общие монографии на русском языке, посвященные теоретическим основам риторической и гомилетической науки, биографические исследования великих каппадокийцев и свт. Иоанна Златоуста, публикации в периодических изданиях. Также рассматриваются наиболее значительные работы зарубежных авторов, непосредственно посвященные теме влияния античного красноречия на христианскую гомилию проповедников Золотого века.

The article discusses theoretical studies on ancient rhetoric and Christian homily, the study of which can contribute to scientific research in the field of the influence of ancient rhetoric on the Christian preaching of the IV century. The review includes general monographs in Russian devoted to the theoretical foundations of rhetorical and homiletic science, biographical studies of the great Cappadocians and the St. John Chrysostom, publications in periodicals. The most significant works of foreign authors directly devoted to the topic of the influence of ancient eloquence on the Christian homily of the preachers of the Golden Age are also considered.
Образ священника в романе Грэма Грина «Сила и слава»
Authors: Иван Алексеевич Пеньков
Published: November 2024

Данная статья представляет собой исследование романа Грэма Грина «Сила и слава» на предмет особенностей литературного изображения содержащегося в тексте образа священника. Избранный автором исторический контекст романа позволяет очень остро раскрыть суть противоречий между принципами религиозной и светской (материалистической) идеологий. При этом демонстрируется процесс динамического развития личности, оказавшейся в перипетиях жизненных условий. Кроме того, в комплексном образе священника (составленном из литературных героев, отождествляемых с пасторами) прослеживается определенное тяготение к самоанализу, акцентированное на противоречиях между собственным призванием и личными наклонностями, военным положением и Евангельским учением, желаниями и обязанностями. Таким образом автор достигает полноты раскрытия художественных образов личностей посредством не самых привычных методов. Он разделяет кардинально разных персонажей, которые в своей совокупности демонстрируют полноту красок, отражающую внутренние борения и переживания, приводящие главного героя к гибели, которая, однако, является лишь очередным этапом действия высшего служения, носителем которого является священник.

This article is a study of Graham Greene’s novel «The Power and the Glory» for ways of literary depiction of the image of a priest contained in the text. The historical context which was chosen by the author makes to very acutely reveal the essence of the contradictions between the principles of religious and secular, materialistic ideologies, while demonstrating the process of dynamic development of an individual, who finds himself in the vicissitudes of fate. In addition, in the complex image of the priest (composed of literary characters identified with pastors), a certain direction of introspection can be traced, focusing on the contradictions between one’s own calling and personal inclinations, military situation and the Gospel teaching, desires and responsibilities. Thusly the author reaches the climax of revealing the character through not the most conventional methods: separating several radically different characters, which in their totality fullness of qualities, reflecting the internal struggles and experiences that lead the main character to death, which, however, is only the next stage in the development of higher service, the executor of which is the priest.
Страх смерти и поиск бессмертия в творчестве Мориса Метерлинка
Authors: Даниил Алексеевич Огнев
Published: November 2024

В статье рассматриваются религиознофилософские воззрения Мориса Метерлинка через призму страха смерти. Анализируется тема страха смерти и поиска бессмертия в творчестве Метерлинка. В ранних пьесах Метерлинк отрицает возможность воскресения, подчеркивает абсолютность смерти. В поисках бессмертия он всё дальше отходит от христианства, приближаясь к анимизму и пантеизму, и в этом отношении представляет собой пример безусловно талантливого художника, искавшего, но так и не обрётшего бессмертия.

The article examines the religious and philosophical views of Maurice Maeterlinck through the prism of the fear of death. The theme of fear of death and the search for immortality in works by Maeterlinck is analyzed. Maeterlinck denies the possibility of resurrection and emphasizes the absoluteness of death in early plays. Seeking for immortality, he moves further and further away from Christianity, approaching animism and pantheism, and in this regard, he is an example of an undoubtedly talented artist who sought, but never found immortality.
Отсылки к русской литературе в лекциях митрополита Антония Сурожского (на материале книги «Красота и уродство. Беседы об искусстве и реальности»)
Authors: Анастасия Михайловна Ермолаева , Михайловна Ермолаева Виктория
Published: November 2024

В работе анализируются отсылки к русской литературе, которые имеются в лекциях митрополита Антония Сурожского, прозвучавших в 1982 году в Университете графства Кент на чтениях памяти Т. С. Элиота. Материалом для исследования послужила книга «Красота и уродство. Беседы об искусстве и реальности», представляющая собой стенограмму и перевод данных лекций на русский язык. Представляется актуальным установить, какие архетипические черты усматривает митрополит Антоний Сурожский в произведениях русской литературы, в биографиях русских писателей, как отсылки к русской литературе вписаны оратором в общий контекст мировой литературы, а также христианской морали и эстетики. Во внимание были взяты авторы, которые, по мнению митрополита, вносят нерушимое представление о сущности человеческой красоты; о предназначении литературы как проявления словесного искусства и взаимодействии внутреннего и внешнего мира христианской личности.

The article deals with the references of Russian literature in the lectures of Metropolitan Anthony of Sourozh. These lectures were presented at the University of Kent in remembrance of Thomas Stearns Eliot in 1982. The book «Beauty and ugliness. Talk about Art and Reality» was the data for study. It presents a transcript translation of these lectures into Russian. The article establishes the biographies of Russian writers and identifiable archetypal features in Russian literature noticed by Metropolitan Anthony. The analyze shows the input of the references in the general context of world literature which bring an indestructible idea to the essence of human beauty, according to the Metropolitan’s opinion.
Role of mod(mdg4)-67.2 protein in interactions between su(hw)-dependent complexes and their recruitment to chromatin
Authors: Melnikova L. S. , Molodina V. V. , Georgiev P. G. , Golovnin A. K.
Published: November 2024

Su(Hw) belongs to a class of proteins that organize chromosome architecture, determine promoter activity, and participate in the formation of boundaries/insulators between regulatory domains. This protein contains a cluster of 12 zinc fingers of the C2H2 type, some of which are responsible for binding to the consensus site. The Su(Hw) protein forms a complex with the Mod(mdg4)-67.2 and the CP190 proteins, where the last one binds to all known Drosophila insulators. To further study the functioning of Su(Hw)-dependent complexes, we used the previously described su(Hw)E8 mutation, with inactive seventh zinc finger, which produced the mutant protein losing the ability to bind to the consensus site. The present work shows that the Su(Hw)E8 protein continues to directly interact with the CP190 and Mod(mdg4)-67.2 proteins. Through interaction with Mod(mdg4)-67.2, the Su(Hw)E8 protein can be recruited into Su(Hw)-dependent complexes formed on chromatin and enhance their insulator activity. Our results demonstrate that DNA-unbound Su(Hw)-dependent complexes can be recruited to Su(Hw)-binding sites through specific protein-protein interactions that are stabilized by Mod(mdg4)-67.2.
Modification of the hi-c technology for molecular genetic analysis of formalin-fixed paraffin-embedded sections of tumor tissues
Authors: Gridina M. M. , Stepanchuk Ya. K. , Nuriddinov M. A. , Lagunov T. A. , Torgunakov N. Yu. , Shadsky A. A. , Ryabova A. I. , Vasiliev N. V. , Vtorushin S. V. , Gerashchenko T. S. , Denisov E. V. , Travin M. A. , Korolev M. A. , Fishman V. S.
Published: November 2024

Molecular genetic analysis of tumor tissues is the most important step towards understanding the mechanisms of cancer development, and it is also necessary for the choice of targeted therapy. Hi-C (high-throughput chromatin conformation capture) technology can be used to detect various types of genomic variants, including balanced chromosomal rearrangements: inversions and translocations. In this work, we propose a modification of the Hi-C method for the analysis of chromatin contacts in formalin-fixed paraffin-embedded (FFPE) sections of tumor tissues. Our results demonstrate that this protocol allow to generate high-quality Hi-C data and detect all types of chromosomal rearrangements. We have analyzed various databases to compile a comprehensive list of translocations that hold clinical importance for targeted therapy selection. The practical value of molecular genetic testing is its ability to influence patient treatment strategies and provide prognostic insights. Detecting specific chromosomal rearrangements can guide the choice of targeted therapies, which is a critical aspect of personalized medicine in oncology.
Nonspecific interactions in transcription regulation and organization of transcriptional condensates
Authors: Valyaeva A. A. , Sheval E. V.
Published: November 2024

Eukaryotic cells are characterized by a high degree of compartmentalization of their internal contents, which ensures precise and controlled regulation of intracellular processes. During many processes, including different stages of transcription, dynamic membrane-free compartments called biomolecular condensates are formed. Transcription condensates contain various transcription factors and RNA polymerase and are formed by high and low specificity interactions between protein factors, DNA and nearby RNA. This review discusses recent data demonstrating the important role of nonspecific multivalent protein-protein and RNA-protein interactions in the organization and regulation of transcription.
Acrylate reductase of an anaerobic electron transport chain of the marine bacterium shewanella woodyi
Authors: Bertsova Y. V. , Serebryakova M. V. , Bogachev V. A. , Baykov A. A. , Bogachev A. V.
Published: November 2024

Many microorganisms are capable of anaerobic respiration in the absence of oxygen, by using different organic compounds as terminal acceptors in electron transport chain. We identify here an anaerobic respiratory chain protein responsible for acrylate reduction in the marine bacterium Shewanella woodyi. When the periplasmic proteins of S. woodyi were separated by ion exchange chromatography, acrylate reductase activity copurified with an ArdA protein (Swoo_0275). Heterologous expression of S. woodyi ardA gene (swoo_0275) in Shewanella oneidensis MR-1 cells did not result in the appearance in them of periplasmic acrylate reductase activity, but such activity was detected when the ardA gene was co-expressed with an ardB gene (swoo_0276). Together, these genes encode flavocytochrome c ArdAB, which is thus responsible for acrylate reduction in S. woodyi cells. ArdAB was highly specific for acrylate as substrate and reduced only methacrylate (at a 22-fold lower rate) among a series of other tested 2-enoates. In line with these findings, acrylate and methacrylate induced ardA gene expression in S. woodyi under anaerobic conditions, which was accompanied by the appearance of periplasmic acrylate reductase activity. ArdAB-linked acrylate reduction supports dimethylsulfoniopropionate-dependent anaerobic respiration in S. woodyi and, possibly, other marine bacteria.
The terror of the red partisans against the clergy and believers during the Civil War in the South-Western Siberia: an experience of generalization
Authors: Gorbatov Alexey , Maltsev Maxim
Published: November 2024

The article summarizes the results of the analysis of a dramatic chapter in the history of the Russian Orthodox Church (ROC) during the civil war in the South-Western Siberia. Based on archival material and information from publications of the early 20th century, as well as the works of Siberian historians, this study examines the reasons for the persecution of clergy, the geographical distribution of the red “partisanism” activities, the connection between anarcho-syndicalism and terror. In additions, the paper estimates approximate the number of victims and the consequences of these tragic events. It was revealed that pogroms of believers and clergy, robbery and destruction of prayer facilities took place everywhere throughout South-Western Siberia. The escalation of terror was exacerbated by the influence of anarchist ideas among the commanding staff of the partisan detachments, who took an implacable and more radical attitude than the Bolsheviks to the institution of the church and the clergy.
European culture, World War, Russian Revolution. Pathways and prospects for rethinking
Authors: Buldakov Vladimir P.
Published: November 2024

The author shows that the First World War was a cultural phenomenon in its broad, creative and historical sense. At the same time, the war turned out to be the personification of the crisis of European culture as an existential whole. This affect Russia, which torn between the Europeanized culture of the upper classes and the archaic consciousness of the lower classes.
A historian in power
Authors: Puchenkov Alexander S.
Published: November 2024

The article is devoted to the analysis of the book by the St. Petersburg historian Inna Evgenyevna Barykina, the main character of which is the famous political figure of the era of Alexander II and Alexander III, Count Dmitry Andreevich Tolstoy, who for several decades headed the most important departments of Tsarist Russia - the Ministry of Internal Affairs, the Ministry of Public Education and served as the chief prosecutor of the Holy Synod. The author notes the serious scientific level of the monograph, based on a wide range of sources, and the extraordinary character of Count Tolstoy, one of the most prominent representatives of the autocratic bureaucracy, is noted.
The «university question» in the Russian government policy at the beginning of the 20th century
Authors: Tumanova Anastasiya S.
Published: November 2024

The text written by A.S. Tumanova is a review on the monograph of A.E. Ivanov, which analyzes the policy of the autocracy in relation to universities in 1899–1908.
Why did faith lose to ideology?
Authors: Kotsyubinsky Daniil A.
Published: November 2024

The article is devoted to the analysis of the role of the religious factor in the Russian Civil War and its coverage in the collective monograph of St. Petersburg historians.
The Labor movement and Revolutionary Social Democracy in the borderlands of late Imperial Russia
Authors: Bogomolov Igor K.
Published: November 2024

A review of a new monograph by Professor Eric Blanc of Rutgers University (USA) is presented. The book is devoted to the history of the labor movement and the development of revolutionary social democracy on the outskirts of the Russian Empire from 1882 (the year of the creation of the first social democratic organization in Poland) to the revolutionary 1917. Blanc focuses specifically on the "non-Russian" socialist parties in the territory of modern Poland, Ukraine, the Baltic States, Georgia and Armenia. The author concludes that the development of the socialist and labor movement in the border areas of late Imperial Russia was characterized by greater radicalism, a more developed structure and popularity among the local working class. At the same time, the situation in Finland with its autonomy and legalized party struggle, which could include socialists, differed from the virtually illegal life of social democracy in Poland and the Caucasus.
ВПЛИВ ДЕРЖАВИ НА РІВЕНЬ ІНТЕРНАЦІОНАЛІЗАЦІЇ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ: ДОСВІД ПОЛЬЩІ
Authors: ЧЕРНЯКОВА Жанна , ОСТЕНДА Александер , БАРЧУК Євгенія , КАПЛУНОВСЬКА Алла
Published: November 2024

Інтернаціоналізація вищої освіти є важливим компонентом стратегії багатьох країн, спрямованої на посилення міжнародної співпраці, підвищення конкурентоспроможності університетів та інтеграцію наукового потенціалу в глобальний освітній простір. Приклади країн ЄС свідчать про важливість наявності національних стратегічних документів, які визначають довгострокові цілі та напрямки розвитку інтернаціоналізації науки і освіти. Перед Польщею також стоїть задача розробки національної стратегії інтернаціоналізації, що базуватиметься на державній науковій політиці та відповідному законодавчому забезпеченні. Очікується, що така стратегія сприятиме інтеграції польських вишів у міжнародний академічний простір та розвитку науки. Ключовим індикатором інтернаціоналізації є кількість іноземних студентів у польських університетах, яка відображає здатність університетів інтегруватися у глобальні процеси. Вплив держави на залучення іноземців реалізується через політики фінансової підтримки, візової лібералізації та спрощення адміністративних процедур, розвиток міжнародних освітніх програм та популяризацію польської освіти за кордоном. Приватні університети демонструють вищі показники інтернаціоналізації завдяки орієнтації на іноземних студентів. Проте польська візова політика потребує покращень через зловживання легким доступом на навчання, коли справжньою метою є робота чи еміграція в інші країни Шенгенської угоди. У зв’язку з цим МЗС Польщі запровадило зміни у візовій системі, серед яких підвищення вимог до кандидатів та обмеження доступу до ринку праці. Аналітичний огляд польського досвіду свідчить про значну роль державної підтримки у досягненні цілей інтернаціоналізації, що є перспективним напрямком подальших досліджень у сфері освітньої політики.
Influence of temperature, solvent and extraction procedure on the content of phenolic compounds and antioxidant activity of Aloysia citriodora Palau leaves
Authors: Garnica-Romo Ma. Guadalupe , Sánchez Pahua Claudia Iveth , Martinez-Flores Hector Eduardo
Published: November 2024

Introduction: The leaves of Aloysia citriodora Palau are a source of phenolic compounds that have antioxidant properties.
Objective: The objective of this study was to compare the effects of temperature, type of solvent, maceration, and ultrasound processes in the extraction of phenolic compounds from A. citriodora Palau leaves that allow for maintaining the highest antioxidant capacity.
Methods: In this study, phenolic compounds were extracted from A. citriodora by two methods, maceration, and ultrasonic treatment, using water and 80% ethanol as solvents and extraction temperatures of 25 °C, 45 °C, and 65 °C. Total phenolic compounds (TPhen), total flavonoid compounds (TFlav), and antioxidant capacity, evaluated by DPPH and ABTS assay, were characterized and reported as inhibition concentration (IC50).
Results: The highest CPhen content was obtained with ethanolic extract using the ultrasonic method at 65 °C, with a value of 15.32 mg EAG/mL at 65 °C. For TFlav, the highest value was obtained with the ultrasonic treatment at 45 °C using ethanol as solvent, obtaining a value of 6.52 mg EQ/mL. The best antioxidant capacity was shown by the sonication with ethanol at 65 and 45 °C, with IC50 values of 27.10 µg/mL and 20.40 µg/mL, respectively.
Conclusion: Ultrasound extraction at higher temperatures (45°C and 65°C) proved more effective than maceration, yielding greater amounts of phenolic and flavonoid compounds and exhibiting better antioxidant capacity.”.
Keywords: Aloysia citrodora, phenolic compounds, antioxidant activity, inhibitory concentration IC50.
Representation of solutions of M-spectral problem for diffusion operator
Authors:   University of Firat, Elazig, T¨urkiye, Bas Erdal , Karaoglan Merve , Panakhov Etibar ,   Institute of Applied Mathematics at Baku State University, Baku, Azerbaijan
Published: November 2024

In this article, we offer the M-Sturm Liouville problem for the diffusion operator depending on initial condition. We obtain the representation of the solution of the M-Sturm Liouville problem for diffusion operator through the M-Laplace transform. The purpose of this article is to advantage demonstrate a more generalized version of the representation of the solution of the Sturm Liouville problem for diffusion operator in classical analysis.
The A-integral and Calderon-Zygmund operators
Authors:   Baku State University, Baku, Azerbaijan, Huseynli A.F.
Published: November 2024

It is known that the function obtained by the action of the Calderon-Zygmund operator on a Lebesgue integrable function can be non-Lebesgue integrable. In this paper, we prove that the function obtained by the action of the Calderon-Zygmund operator on a Lebesgue integrable function is A-integrable and derive an analogue of the Riesz equality.
Uniqueness criteria for inverse scattering problem in terms of transmission matrix in boundary condition for a first order system of ordinary differential equations
Authors:   Gebze Technical University, Kocaeli, T¨urkiye, Ismailov M.I. , Sabaz Cihan
Published: November 2024

The inverse scattering problem (ISP) involves the recovery of the matrix coefficient of a first-order system on the half-line from its scattering matrix. Specifically, when the matrix coefficient exhibits a triangular structure, the system possesses a Volterra-type integral transformation operator at infinity. This transformation operator facilitates the determination of the scattering matrix on the half-line through matrix Riemann-Hilbert factorization. Solving the ISP on the half-line entails reducing it to an ISP on the whole line for the considered system. This reduction involves extending the coefficients to the whole line by zero. The uniqueness criteria in terms of transmission matrix in boundary condition for the ISP is also established.
Vasculite de hipersensibilidade à amoxicilina: relato de caso clínico
Authors:   USF Tílias, Rocha Maria José , Melo Gonçalo ,   USF Tílias
Published: November 2024

Introdução: As vasculites são um grupo heterogéneo de doenças imunomediadas definidas pela inflamação dos vasos sanguíneos. Podem afetar vasos de qualquer calibre, resultando numa ampla variedade de sinais e sintomas, o que dificulta o seu diagnóstico. O caso clínico apresentado mostra a importância de uma anamnese e exame objetivo cuidados, atentando em potenciais fatores desencadeadores, nomeadamente a toma de medicação. Descrição do caso: Homem, 71 anos, com antecedentes pessoais de hipertensão arterial, hipertrigliceridemia e hipertrofia benigna da próstata, medicado com losartan + amlodipina e dutasterida + tansulosina. Recorreu à consulta por quadro compatível com infeção respiratória baixa, não complicada. Foi feito o diagnóstico de pneumonia adquirida na comunidade e medicado com amoxicilina 500mg 8/8h durante sete dias, com melhoria sintomática. Contudo, ao décimo dia após iniciar antibiótico inicia um agravamento progressivo com prostração, hemorragia subconjuntival bilateral e surgimento de novo de lesões maculares dolorosas ao toque dispersas nas palmas das mãos e face ventral dos punhos. Nas análises destacavam-se alterações sugestivas de inflamação e autoimunidade, pelo que se presumiu diagnóstico de vasculite de hipersensibilidade à amoxicilina, tendo sido medicado com corticoterapia com melhoria sintomática. Comentário: Neste caso, a apresentação multissistémica e com boa resposta à corticoterapia aponta para um diagnóstico de vasculite. As lesões cutâneas associadas a episclerite e astenia são mais sugestivas de vasculite dos pequenos vasos. Esta é potencialmente secundária a uma reação de hipersensibilidade à medicação com amoxicilina, tendo em conta a evolução temporal do quadro, sugestiva de associação. Para realizar este difícil diagnóstico, o médico de família, pela natureza do seu trabalho e acompanhando longitudinalmente o doente, está capacitado para identificar casos com evolução temporal e associações entre patologias e medicações anteriores.
Uncontrolled chronic pain: can a pain consultation in primary care be a solution?
Authors: Pedrosa Bruno Ferreira , Martins Marília , Santos Catarina
Published: November 2024

Chronic pain is one of the most frequent medical problems in Portuguese primary health care. These patients significantly show poorer functioning capabilities and quality of life than the general population. The importance of improving the quality of life in patients suffering from chronic pain is paramount, and a holistic approach must be implemented. However, proper pain evaluation and management may be time-consuming in a routine primary health care consultation. Given the significant impact of this disease, we initiated a dedicated consultation for patients with chronic pain in our primary health care unit. A complete evaluation is performed, and, among other questionaries, the Brief Pain Inventory is applied to evaluate pain impact on functioning at the first appointment and re-evaluated after six months of follow-up. In the first six months, 31 patients with uncontrolled pain were referred by their family physicians to this consultation. Non-pharmacological strategies were strongly recommended alongside pharmacological therapies. Although this consultation is relatively recent, our patients with longer follow-ups showed improvement in both maximum and minimum pain levels and substantial improvement in all the measured interferences in the Brief Pain Inventory. Even though there is literature that thoroughly describes the impact of pain on patients’ quality of life, there is much to be done to change this problem. Since family physicians know their patients and their contexts well, they are in a privileged position to manage this problem, and a specific pain consultation in primary health care can be one of the best services for managing pain.
Satisfação e avaliação do internato de medicina geral e familiar em diferentes modelos de organização: estudo observacional
Authors:   USF Casa dos Pescadores, Pires Vera , Loureiro Maria da Luz ,   Coordenação do Internato de Medicina Geral e Familiar da Zona Norte
Published: November 2024

Objetivos: Perceber se o modelo organizacional da unidade de saúde em que decorre o internato em medicina geral e familiar tem impacto na satisfação dos médicos internos e nas notas de avaliação. Métodos: Estudo observacional transversal, componente analítico. População: médicos que terminaram a sua formação em 2021/2022 na zona Norte de Portugal. Questionário de satisfação e consentimento informado enviados por correio eletrónico e obtidos dados sobre as notas de avaliação. Parecer favorável da Comissão de Ética. Resultados: Obtiveram-se 168 respostas (60%). Na escolha do local formativo, as expectativas eram estatisticamente mais elevadas em quem escolheu as USF B (p=0,031). Afirmaram estar totalmente/muito satisfeitos 77,3% (54,6% UCSP, 74% USF A, 80% USF B); maior satisfação foi relativamente à oportunidade de realizar consultas de forma autónoma, acolhimento e oportunidade de apresentar trabalhos. O trabalho em equipa foi mais apreciado em USF B 76,2%, 70,4% em USF A e 36,4% em UCSP. Apenas 57,7% sentiram o seu horário respeitado (72,8% em UCSP, 66,6% em USF A e 54,6% em USF B). As notas de avaliação contínua foram estatisticamente superiores nas USF em relação às UCSP (p=0,006); as de avaliação final foram estatisticamente superiores nas USF B em relação às UCSP (p=0,033). Discussão e Conclusão: O modelo organizacional da unidade de saúde teve impacto na satisfação dos médicos internos, bem como nas notas de avaliação. Seria importante aplicar o estudo a nível nacional, incluir outras variáveis e efetuar um estudo longitudinal, acompanhando a satisfação ao longo do internato.
Perceção dos médicos de família acerca da abordagem da saúde mental em consulta
Authors:   UCSP Sátão, Pereira Ana Rita , Carvalho Anabela ,   Instituto Politécnico de Viseu, Azevedo Márcia ,   USF Cândido Figueiredo, Brás José ,   USF Cândido Figueiredo
Published: November 2024

Introdução: As perturbações mentais são uma das principais causas de incapacidade para a atividade laboral em Portugal e de procura de consulta nos cuidados de saúde primários (CSP), encontrando-se muitos destes doentes acompanhados exclusivamente pelo seu médico de família (MF). Objetivos: Avaliar a formação em saúde mental nos CSP, o grau de importância dada à saúde mental pelos MF e a sua capacidade em abordar a mesma em consulta. Método: Estudo observacional, transversal e descritivo. Questionário original online dirigido aos MF, explorando dados socioprofissionais, formação dos MF em saúde mental e abordagem da saúde mental em consulta. O presente estudo teve parecer favorável da Comissão de Ética da ARS Centro. A análise estatística foi realizada com IBM-SPSS®, v. 28. Resultados: Participaram 449 médicos de família a exercer em distintas regiões do país, sendo 75,3% do sexo feminino e 76% especialistas. Apenas 45% do MF têm formação em saúde mental e a generalidade da amostra considera que há formações com qualidade, mas são escassas. Os inquiridos dão importância à abordagem da saúde mental. Porém, apenas os clínicos com mais experiência e mais formação apresentam maior confiança na sua abordagem. Conclusão: No presente estudo verifica-se uma taxa reduzida de MF com formação específica em saúde mental, sendo que, os que a têm, referem maior confiança e apresentam mais conhecimentos na patologia psiquiátrica. Assim, torna-se evidente a necessidade de aumentar a disponibilidade de formações para os MF tendo como meta melhorar a abordagem da saúde mental nos CSP.
Assessment of chronic pain: multidimensional tools, applicability, and practicality
Authors:   Faculdade de Medicina e Ciências Biomédicas Universidade do Algarve, Miranda Rui Vicente , Neves Nuno ,   Faculdade de Medicina da Universidade do Porto
Published: November 2024

Introduction: Chronic pain (CP) negatively impacts patients’ physical and psychological status. Thus, it has the potential to affect every aspect of everyday life. In Portugal, CP is a major public health problem that affects roughly 36.7% of adults. Nevertheless, assessment of this condition is still far from ideal. A Portuguese study showed that most of last year’s medical students and first-year residents did not routinely assess pain. Additionally, the best-known pain assessment tools are the ones that focus only on pain intensity, thus disregarding the multidimensional nature of pain. Objectives: This study aims to review pain assessment tools that consider the nature of pain and its impact on patients' functionality. The ultimate goal is to increase the knowledge and dissemination of such tools. Methods: Focus groups were conducted with a panel of 29 Portuguese physicians specialized in family medicine and orthopaedics. Several pain assessment tools were debated regarding applicability, practicality, and relevance. After group discussion, five pain assessment tools were considered particularly relevant. Results: The characteristics, advantages, and disadvantages of five pain assessment tools (ACT-UP, CAPA, Barthel index, BPI, and EQ-5D), and the need for their applicability in the family medicine clinical practice are summarized and highlighted. Functional assessment of CP patients is a key step to deciding the most adequate treatment regimen since the individual nature of patients will cause them to be differently affected by distinct limitations, even if the intensity of pain is similar. Conclusion: The implementation use of these tools in clinical practice will be crucial for the improvement of CP management.
Inércia terapêutica na osteoporose em mulheres pós-menopáusicas
Authors:   USF Garcia de Orta, Silva Mariana Cruz da , Outeirinho Conceição ,   USF Barão de Nova Sintra, Lopes Nina ,   USF Garcia de Orta, Gonçalves Maria João ,   USF Garcia de Orta, Mina Isabel ,   USF Garcia de Orta, Pimentel Alexandra ,   USF Garcia de Orta, Costa Rodrigo ,   USF São João do Porto, Bento Inês ,   USF Garcia de Orta, Calafate Ana ,   Departamento Médico da Medinfar, Henriques Manuel ,   USF Garcia de Orta, Sottomayor Henrique ,   USF Garcia de Orta
Published: November 2024

Introdução: A osteoporose (OP) é a doença óssea metabólica mais frequente, associando-se a fraturas de fragilidade e aumento de morbimortalidade. Apesar do envelhecimento populacional tem-se verificado uma tendência decrescente na implementação de terapêutica antiosteoporótica. Objetivos: Determinar a inércia terapêutica na OP em mulheres pós-menopáusicas ao nível dos cuidados de saúde primários. Verificar se existe associação entre a idade dos utentes, o T-score e o valor de FRAX e a inércia terapêutica antiosteoporótica. Métodos: Estudo observacional transversal. Critérios de inclusão: mulheres com idades entre os 55 e os 85 anos codificadas com OP (ICPC2 – L95) ou fraturas (ICPC2 – L72-76) na lista de problemas. Foi selecionada uma amostra aleatória simples. A inércia terapêutica foi definida com base nas recomendações da Sociedade Portuguesa de Reumatologia. Resultados: Obteve-se uma amostra de 217 utentes. Apurou-se inércia terapêutica em 17,5% das mulheres, valor que aumenta para 48,6% nas que sofreram fraturas (p<0,001). As idades diferem de forma estatisticamente significativa entre os utentes com e sem inércia terapêutica (77,5 vs 73,0, p<0,010). A mediana do FRAX para fratura osteoporótica major (16,5 vs 9,65, p<0,001) e fratura da anca (7,6 vs 3,3, p<0,001) foi superior no grupo com inércia terapêutica. Os valores de T-score da coluna lombar (2,45 vs 2,71) e do colo do fémur (2,07 vs 2,02) não diferiram de forma estatisticamente significativa (p=0,299). Conclusão: Este estudo realça a aplicação da evidência mais atual ao nível do tratamento da OP na unidade estudada, mas salienta a necessidade de maior intervenção na OP fraturária e em idades mais avançadas.