bluuebunny/crossref_metadata_2025 huggingface dataset:
Marcas de urgencia: la marca turística española en el primer año de la pandemia de covid-19
Authors: Goycoolea Prado Roberto , Núñez Martí Paz
Published: April 2024

Con las declaraciones globales de confinamientos y cierre de fronteras en marzo de 2020, el turismo —una de las industrias más boyantes del planeta y esencial para la vida de muchos destinos e, incluso, países— se detuvo, con drásticas y conocidas consecuencias socioeconómicas. Pasada la virulenta primera ola de contagios, en el verano se produjo en España una reapertura vigilada. Para responder a esta inédita situación, los promotores turísticos se vieron obligados a desarrollar campañas publicitarias de urgencia y, con ello, a reformular sus marcas turísticas. Lo nuevo fue que comenzaron a destacar aspectos de los lugares que no eran habitualmente resaltados. El objetivo de este capítulo es reflexionar sobre el papel y la influencia de las marcas de lugar en el negocio turísticos, estudiando en una de las más conocidas y reputadas del mundo, la española, los cambios experimentados durante la pandemia de covid-19. El análisis se realizó registrando y comparando los mensajes subyacentes en la publicidad de urgencia desplegada en el ámbito institucional y empresarial. Los resultados permiten entender la naturaleza cambiante, condicionada y comercial de las marcas turística de lugar por sobre su enaltecida función simbólica e identitaria.
Estambul: entre la marca de una historia y la historia de una marca. Un recorrido de calles y misterios de la mano de Pamuk
Authors: González Escobar Luis Fernando
Published: April 2024

Estambul existe como realidad histórica concreta, pero también como un gran imaginario, en ambos casos múltiple y prácticamente inabarcable. Aunque las narraciones y el turismo la han reducido a ciertos arquetipos, ¿qué hay más allá de lo evidente y arquetípico? Como turista y viajero académico me pregunto qué puedo visualizar en una breve permanencia en una ciudad tan extensa, densa y con un acumulado urbano de más de 8000 años. Unos pocos días a ritmo frenético me ponen enfrente de cómo superar la condición de viajero indolente y es allí donde el diálogo entre la corta experiencia del visitante interesado con la del lector del libro Estambul, de Orhan Pamuk, se ponen en relación para acortar la distancia en la ciudad imaginada, la narrada y la construida, a la vez que encontrar las trazas de un paisaje mejor delineado y menos efímero. La obra de Pamuk sirve de referencia para adentrarnos en autores que lo antecedieron en la construcción de un imaginario y un paisaje estambulí, para confrontarlo con los imaginarios que se han construido al servicio de la industria del turismo. Entre ese paisaje histórico y esos imaginarios se decanta una mirada intermedia para aprehender de mejor manera esa ciudad del presente, apenas como para rasguñar la complejidad y profundidad del paisaje estambulí. Esta es la propuesta de lectura que hace el autor en este capítulo.
Assessing post-analytical phase harmonization in European laboratories: a survey promoted by the EFLM Working Group on Harmonization
Authors: Zaninotto Martina , Agnello Luisa , Dukic Lora , Akhvlediani Leila
Published: April 2024

Objectives

Harmonization of the laboratory total testing process (TTP) is critical to improving patient outcome. In 2016, an EFLM survey on the harmonization of TTP underlined the serious shortcomings pertaining to the post-analytical phase. In 2023, the WG-H conducted a new survey aiming to update information in the 2016 harmonization report in order to ascertain whether countries that had declared they were keen to adopt SI units had continued with this program, the aim being to verify the state-of art in harmonization units in areas of laboratory medicine not included in the previous survey.

Methods

Questionnaires were distributed to the Presidents and National Representatives of EFLM Full Member Societies and EFLM affiliate Members. The survey questions were grouped into three categories: measurement units, reference intervals, and nomenclature/terminology, and results were evaluated using Survey Monkey software and Excel.

Results

A total of 123 questionnaires from 31 countries were analyzed. A trend (+19.3 %) was observed toward a wider use of SI units for general clinical biochemistry parameters. The results for tests not included in the 2016 survey (i.e., endocrinology diagnostics and coagulation panels), demonstrated that for reports on hormones, responses were satisfactory, 70–90 % of the responders adopting the recommended units, whereas for coagulation test panels, a serious lack of harmonization was found, “seconds”, which are inaccurate and not recommended, being widely used units (91 %).

Conclusions

The findings made in the 2023 survey demonstrated a progressive, albeit slow, improvement in harmonization reports. However, further efforts at improvement are mandatory.
Convergence of an Operator Splitting Scheme for Fractional Conservation Laws with Lévy Noise
Authors: Behera Soumya Ranjan , Majee Ananta K.
Published: April 2024

In this paper, we are concerned with an operator-splitting scheme for linear fractional and fractional degenerate stochastic conservation laws driven by multiplicative Lévy noise.
More specifically, using a variant of the classical Kružkov doubling of variables approach, we show that the approximate solutions generated by the splitting scheme converge to the unique stochastic entropy solution of the underlying problems.
Finally, the convergence analysis is illustrated by several numerical examples.
Unraveling the seriousness fallacy: a case for (the study of) humor and religion
Authors: Graham Nicole
Published: April 2024

This article establishes and demonstrates the importance of the topic of humor and religion. It traces the evolution of the existing scholarship on humor and religion, from its emergence in the 1960s, to its revival in the 1990s, and its latest resurgence in recent years. To overlook the presence of the comic, humor, and laughter in religious traditions is to overlook something significant. This article will demonstrate how interrogating and overcoming biases and preconceptions about the relationship between humor and religion reveals opportunities in both religious studies and humor studies. As such, this article offers a rejection of the existing privilege that is granted to ‘serious’ matters and argues for the inclusion of the non-serious – with a particular emphasis on humor – within (the study of) religion. In arguing for the necessity of taking the study of the (allegedly) non-serious seriously, the artificial nature of the binary of serious/non-serious becomes apparent. As such, this article begins to challenge and re-evaluate the conceptualization of ‘the serious’ and the limitations this inevitably places on our thinking and engagement regarding matters such as humor and religion.
Laughing and humor in ancient Egyptian monasticism
Authors: Gilhus Ingvild Sælid
Published: April 2024

The goal of this article is to analyze laughter and humor in the Egyptian monastic and ascetic movement in the 4th and 5th centuries with a special focus on solitary and non-humorous laughter. The article argues that laughter and humor were part of a strict emotional regime. It shows that several of the monastic stories include a laughter which is not humorous and where no one else laughed apart from the main character. This laughter was a means to show spiritual excellence and superiority. The other side of the emotional regime was that monastics were scolded for laughing and joking. There is a division between illegitimate laughter caused by humor and frequently connected to eroticism and a legitimate laughter of spiritual insight and authority. The article argues that non-humorous laughter should get more attention in contemporary research.
Crisis Constitutionalism
Authors: Bakshi Kushagr
Published: April 2024

Modern constitutions often contain ‘emergency’ provisions which confer upon the executive, the right to assume unfettered authority free of checks and balances, to respond to extra-constitutional crisis situations. Constitutional theorists, relying on the debate between Hans Kelsen and Carl Schmitt in the context of the Staatgerichtshof’s decision in Prussia contra Reich, have laid out two contrasting normative visions of these emergency powers. While some envisage emergencies as existing outside the constitutional order, to be resolved by sovereign dictators exercising constituent power, others argue that emergency provisions ought to be understood as within the constitutional structure. Recently, these emergency powers were used by the central government in India to abrogate the constitutionally mandated autonomous status of Jammu and Kashmir, thereby enacting a permanent constitutional change in response to a temporary extra-constitutional situation. Using these changes in Kashmir as an exemplar, this paper examines the normative position of such emergency provisions in Indian constitutionalism. By analyzing the Indian and Jammu and Kashmir constituent assembly debates, Kelsenian and Schmittian visions and comparatively considering the development of emergency jurisprudence in India and Pakistan, this paper argues that the Indian constitution has sought to constrain the exercise of such provisions through the courts by prescribing a democratic ‘constitutional morality’.
The Constitutional Complaint in Kosovo from the Perspective of State Liability and Constitutional Certainty
Authors: Morina Visar
Published: April 2024

This article analyses the constitutional complaint in Kosovo through the lens of governmental liability and constitutional certainty. Although it is one of the most significant legal mechanisms for the protection of human rights in Kosovo, the remedial impact of a constitutional complaint does not appear to be appropriate for granting ‘just satisfaction’ and holding a public authority accountable for a violation of constitutional rights. To make the state’s constitutional liability for human rights violations a reality, additional legislative reforms are necessary. The introduction of ‘constitutional damage’ award in the context of the Kosovan constitutional judiciary is therefore especially pertinent to this end. Such a remedy would hold the state accountable for abuses of human rights originating from the unconstitutional behavior of government officials. It would finally provide victims of constitutional rights violations with appropriate means of legal redress, which is the ultimate end of constitutional justice. The constitutional principle of ‘legitimate expectation’ is also not unimportant in this context. By offering a critical perspective on the Constitutional Court’s case-law, this article argues for the significance of adhering to the ‘legitimate expectations’ principle to ensure equality of the parties in constitutional litigation proceedings and a constant development of constitutional jurisprudence that is vital for the Kosovan democracy.
Investigation of polymers pyrolysis in a solid-gas conical spouted bed: CFD simulation
Authors: Jafari Sobhan , Soltani Hadi , Gholizadeh Mortaza
Published: April 2024

The hydrodynamics of a conical spouted bed was simulated utilizing the Eulerian–Eulerian Two-Fluid Model (TFM) incorporating a kinetic theory of granular flows. The simulations were confirmed with experimental data. To accurately examine the pyrolysis process, the hydrodynamics of the solid bed as well as the heat transfer inside it were analysed separately by considering a precise synthetic model. The effects of gas velocity, particle size, bed length, and temperature were thoroughly investigated. The results indicated that the amount of relative standard deviation increases with an increase in the inlet velocity into the bed. This amount of deviation at the inlet velocity (0.6 m/s for tar and gas flow to its maximum value of 9.1 and 9.4) is not desirable in product production and should be modified so that the amount of gas flow increases and the tar produced reaches the minimum possible amount. Also, the graphs of the relative standard deviation in terms of temperature indicate that the increase in temperature from 730 to 950 K is associated with a relatively smaller fluctuation of the relative standard deviation so that at the temperature of 730 K, it is 7.2 % for tar and 6.4 % for gas flow, while at temperature of 950 K, it is 6.5 % for wire and 6.8 % for gas flow. Finally, the results determined that small-diameter particles have a more significant fountain height and also higher velocity in the spout section.
Structural identification, stability and combination mechanism of calcium-chelating wheat gluten peptides
Authors: Liu Wenying , Wu Hanshuo , Liu Rui , Wang Hualei , Zhang Xinxue , Meng Ganlu , Ren Jie , Gu Ruizeng
Published: April 2024

In order to explore the structures and combination mechanism of wheat gluten peptides-calcium chelate (WOP-Ca) in depth, WOP-Ca were prepared by chelating wheat gluten peptides (WOP) with calcium. The yield of WOP-Ca was determined to be 51.2 ± 2.12 %, and it exhibited a calcium-chelating rate of 58.96 ± 1.38 %. The structural differences between WOP-Ca and WOP were characterized using various analytical techniques, and the results revealed that WOP-Ca and WOP differed in their microstructure, characteristic group absorption peaks, changes in electron cloud distribution, and thermal stability. WOP-Ca demonstrated remarkable stability and resistance to changes in pH, temperature, and in vitro digestion with gastric protease. After undergoing various treatments, the molecular weight distribution in each interval changed very little. Identification of the peptides in WOP-Ca was achieved by utilizing a mass spectrometer, and a total of 39 peptides were identified in WOP-Ca. Among these, 14 peptides with Score ≥ 30 and Coverage ≥ 20 showed bioavailability percentages exceeding 30 %, with half surpassing 50 %. The binding mode between the 14 peptides and Ca2+ was determined to be α linkage. The Ca–O bond lengths ranged from 2.40 to 3.20 Å, indicating the formation of structurally stable complexes. The carboxyl oxygen atoms played a crucial role in binding with Ca2+, with bond lengths ranging from 2.41 to 2.49 Å and 2.43 to 2.46 Å, respectively. The finding suggested that WOP-Ca prepared by chelation may be used as a calcium supplement that could serve as food additives, dietary nutrients, and pharmaceutical agents.
Well-posedness and Tikhonov regularization of an inverse source problem for a parabolic equation with an integral constraint
Authors: Ngoma Sedar
Published: April 2024

We investigate a time-dependent inverse source problem for a parabolic partial differential equation with an integral constraint and subject to Neumann boundary conditions in a domain of

R
d

\mathbb{R}^{d}

,

d
≥
1

d\geq 1

.
We prove the well-posedness as well as higher regularity of solutions in Hölder spaces.
We then develop and implement an algorithm that we use to approximate solutions of the inverse problem by means of a finite element discretization in space.
Due to instability in inverse problems, we apply Tikhonov regularization combined with the discrepancy principle for selecting the regularization parameter in order to obtain a stable reconstruction.
Our numerical results show that the proposed scheme is an accurate technique for approximating solutions of this inverse problem.
Single-crystal structure determination of Tm3B12O19(OH)7
Authors: Teichtmeister Tobias A. , Huppertz Hubert
Published: April 2024

Tm3B12O19(OH)7, monoclinic, C2 (no. 5), a = 23.9849(5) Å, b = 4.4400(1) Å, c = 7.0771(1) Å, β = 94.698(1)°, V = 751.13(3) Å3, Z = 2, R
gt(F) = 0.0106, wR
ref(F
2) = 0.0247, T = 298(1) K.
Strike While the Iron is Hot: Land Trusts, Temperature Anomalies, and Agenda Setting for Local Open Space Referenda
Authors: Zuhlke Samantha , Katz Juniper , Brinkman Emani
Published: April 2024

Despite substantial progress on understanding the influence of nonprofits in the policy process, the role of nonprofits in local agenda setting remains under-examined. Policy for land conservation is a key plank in climate change mitigation strategies making the role of land trusts in agenda setting for land conservation votes an important topic. Prior studies demonstrate that temperature anomalies increase the likelihood that climate change policy appears on state political agendas. We propose that land trusts play a critical role in facilitating this connection at the local level. Temperature anomalies create a policy window which contributes to the likelihood that conservation measures make it onto the political agenda. Combining temperature, land trust presence, and local conservation vote data from U.S. counties from 2009 to 2019, we find that both temperature anomalies and the presence of land trusts increase the probability that a land conservation measure will appear on the local political agenda. Further, we find that the effect of temperature anomalies on the probability of a vote taking place is conditional on land trust presence within the county. The findings advance existing nonprofit theory on ways in which nonprofits engage in the policy process and hint towards promising avenues of future research. The findings also provide practical evidence for practitioners and hold implications for how local policymakers can leverage existing organizations to implement climate change policy.
Enhanced photocatalytic and antibacterial properties of silver–zirconia nanoparticles for environmental pollution treatment
Authors: Dao Phi Hung , Trinh Hoang Nghia , Nguyen Thuy Chinh , Nguyen Anh Hiep , Vu Dinh Hieu , Nguyen Xuan Thai , Hoang Thi Huong Giang , Nguyen Tien Dung , Thai Hoang
Published: April 2024

Silver–zirconia nanoparticles (Ag–ZrO2 NPs) were synthesized via an in situ strategy at room temperature using NaBH4 as a reducing agent. The surface modification of ZrO2 nanoparticles with nano silver was confirmed through various characterization techniques including Fourier Transform Infrared Spectroscopy (FTIR), UV–vis Diffuse Reflectance Spectroscopy (UV–vis DRS), X-ray Diffraction (XRD), and Field Emission Scanning Electron Microscopy (FESEM). The obtained results demonstrated that Ag nanoparticles, with a crystallite size of approximately 12 nm, were uniformly distributed on the surface of ZrO2 nanoparticles. The incorporation of Ag nanoparticles to the ZrO2 nanoparticles led to increasing the light absorption ability and reducing the band gap of Ag–ZrO2 nanoparticles, thereby enhancing their photocatalytic performance under infrared lamp exposure. When 1 g/L of Ag–ZrO2 nanoparticles was employed to methylene blue (MB) solution, the degradation of MB reached 90 % after 5 h of exposure. Additionally, the Ag–ZrO2 nanoparticles exhibited a high antibacterial activity against two bacterial strains, E. coli and S. aureus. These findings highlight the potential of Ag–ZrO2 nanoparticles as effective materials for environmental pollution treatment through advanced oxidation processes.
Assessing the feasibility of statistical inference using synthetic antibody-antigen datasets
Authors: Minotto Thomas , Robert Philippe A. , Hobæk Haff Ingrid , Sandve Geir K.
Published: April 2024

Simulation frameworks are useful to stress-test predictive models when data is scarce, or to assert model sensitivity to specific data distributions. Such frameworks often need to recapitulate several layers of data complexity, including emergent properties that arise implicitly from the interaction between simulation components. Antibody-antigen binding is a complex mechanism by which an antibody sequence wraps itself around an antigen with high affinity. In this study, we use a synthetic simulation framework for antibody-antigen folding and binding on a 3D lattice that include full details on the spatial conformation of both molecules. We investigate how emergent properties arise in this framework, in particular the physical proximity of amino acids, their presence on the binding interface, or the binding status of a sequence, and relate that to the individual and pairwise contributions of amino acids in statistical models for binding prediction. We show that weights learnt from a simple logistic regression model align with some but not all features of amino acids involved in the binding, and that predictive sequence binding patterns can be enriched. In particular, main effects correlated with the capacity of a sequence to bind any antigen, while statistical interactions were related to sequence specificity.
Zwischen Pandemiebekämpfung und ökonomischen Interessen
Authors: Avci Meral , Franke Christian
Published: April 2024

Der Beitrag untersucht, wie die Malariakommission des Völkerbunds in der Zwischenkriegszeit im Spannungsfeld (nationaler) unternehmerischer wie wissenschaftlicher Interessen und der transnationalen Verantwortung konkrete Empfehlungen zur Eindämmung von Malariaepidemien aushandelte. Am Beispiel des dritten Malariaberichts von 1933 wird diskutiert, warum trotz sehr unterschiedlicher Forschungsmeinungen hinsichtlich der Wirksamkeit von Chinin und synthetischen Wirkstoffen (Plasmochin und Atebrin) ein klares Urteil für Chinin gefällt wurde. Der Beitrag zeigt so auch, wie die Malariakommission ihre in den 1920er Jahren erworbene internationale Autorität sukzessive einbüßte und mit dem Rückzug der deutschen und 1937 auch der italienischen Malariaforschung wichtige wissenschaftliche Standbeine verlor.
Aus den Aufzeichnungen eines Attentäters
Authors: Rossoliński-Liebe Grzegorz
Published: April 2024

Die Dokumentation präsentiert zentrale Ausschnitte aus den Erinnerungen des KGB-Agenten Bogdan Staschinski, die im Archiv des Bundesnachrichtendiensts verwahrt werden. Staschinski war ein begabter, aber innerlich zerrissener Attentäter, der wegen seiner Mordanschläge auf die Anführer der Organisation Ukrainischer Nationalisten (OUN) Lew Rebet und Stepan Bandera in die Geschichte der Geheimdienste und des Kalten Kriegs einging. In seinen Aufzeichnungen, die er nach seiner selbst gewollten Verhaftung verfasste, berichtete er – um milde Richter zu finden –, was ihn dazu bewog, sich dem KGB anzuschließen, den nationalistischen Untergrund in der Westukraine erfolgreich zu infiltrieren, Anführer der OUN in München zu ermorden und anschließend dem wohl brutalsten Geheimdienst schlechthin den Rücken zu kehren.
Mechanical and Microstructural Analysis of Lightweight Subgrade Bricks Synthesized from Mixtures of Coal Fly Ash and Sewage Sludge
Authors: Wang Hong , Yu Laihao , Zhang Zhenghao , Zhang Yingyi , Shen Xin , Peng Shiheng
Published: April 2024

The massive discharge of coal fly ash and sewage sludge has placed great pressure on the environment and society. This study proposes a feasible method for producing lightweight subgrade bricks from coal fly ash and sewage sludge. The results show that the lightweight subgrade bricks mainly consist of mullite (3Al2O3·2SiO2), hematite (Fe2O3), sillimanite (Al2SiO5), aluminum phosphate (AlPO4), and a small amount of cristobalite (SiO2). The formation of AlPO4 improved the sintering and mechanical properties of the sintered samples. The formation of voids and cracks in the sintered samples was primarily attributable to the combustion and sintering shrinkage of the organic matter in the mixture. The maximum compressive and flexural strengths were observed when the sewage sludge content was 40 wt. %, and the corresponding compressive strength and flexural strength were 19.86 and 8.57 MPa, respectively. An appropriate amount of sewage sludge improves the connections between coal fly ash particles and promotes the densification of the lightweight subgrade bricks. These results provide a direction for the development of applications for coal fly ash and sewage sludge in the field of building materials.
Advances in MicroRNA-Mediated Regulation of Cardiomyocyte Injury After Coronary Microembolization
Authors: Li Lange , Zheng Yaxuan , Li Kun , Kong Lingyun , Wang Xiujuan , Zhou Boda , Lv Tingting , Liu Fang , Zhang Ping , Xue Yajun
Published: April 2024

Coronary microembolization (CME) occurs in patients with acute coronary syndrome and is caused primarily by atherosclerotic plaque rupture associated with surgery. CME can lead to arrhythmias, decreased coronary blood flow reserve, and cardiac systolic dysfunction. The clinical efficacy of conventional coronary artery dilation, antiplatelet agents, and direct thrombus aspiration after CME is not satisfactory. Studies have indicated that microRNAs (miRNAs) specifically bind the 3′ untranslated regions (UTRs) of inflammatory response-, apoptosis-, and autophagy-related mRNAs, and ultimately affect CME prognosis. In-depth studies of the roles of miRNAs in CME occurrence and development would not only advance understanding of the mechanisms underlying poor prognosis after CME but also aid in identifying new targets for drug treatment. Here, we review the regulatory effects of miRNAs on myocardial cell injury after CME in terms of the inflammatory response, apoptosis, and autophagy. Overall, changes in miRNA levels after CME decrease myocardial autophagy and worsen cardiac prognosis. Current evidence suggests a potential strategic pathway for therapeutic intervention in CME management.
GLP-1 in the Hypothalamic Paraventricular Nucleus Promotes Sympathetic Activation and Hypertension
Authors: Xu Xiao-Yu , Wang Jing-Xiao , Chen Jun-Liu , Dai Min , Wang Yi-Ming , Chen Qi , Li Yue-Hua , Zhu Guo-Qing , Chen Ai-Dong
Published: April 2024

Glucagon-like peptide-1 (GLP-1) and its analogs are widely used for diabetes treatment. The paraventricular nucleus (PVN) is crucial for regulating cardiovascular activity. This study aims to determine the roles of GLP-1 and its receptors (GLP-1R) in the PVN in regulating sympathetic outflow and blood pressure. Experiments were carried out in male normotensive rats and spontaneously hypertensive rats (SHR). Renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded. GLP-1 and GLP-1R expressions were present in the PVN. PVN microinjection of GLP-1R agonist recombinant human GLP-1 (rhGLP-1) or EX-4 increased RSNA and MAP, which were prevented by GLP-1R antagonist exendin 9-39 (EX9-39) or GLP-1R antagonist 1, superoxide scavenger tempol, antioxidant N-acetylcysteine, NADPH oxidase (NOX) inhibitor apocynin, adenylyl cyclase (AC) inhibitor SQ22536 or protein kinase A (PKA) inhibitor H89. PVN microinjection of rhGLP-1 increased superoxide production, NADPH oxidase activity, cAMP level, AC, and PKA activity, which were prevented by SQ22536 or H89. GLP-1 and GLP-1R were upregulated in the PVN of SHR. PVN microinjection of GLP-1 agonist increased RSNA and MAP in both WKY and SHR, but GLP-1 antagonists caused greater effects in reducing RSNA and MAP in SHR than in WKY. The increased superoxide production and NADPH oxidase activity in the PVN of SHR were augmented by GLP-1R agonists but attenuated by GLP-1R antagonists. These results indicate that activation of GLP-1R in the PVN increased sympathetic outflow and blood pressure via cAMP-PKA–mediated NADPH oxidase activation and subsequent superoxide production. GLP-1 and GLP-1R upregulation in the PVN partially contributes to sympathetic overactivity and hypertension.
Curating Young Cinema
Authors: Hutchinson Pamela
Published: April 2024

How can archive cinema seem new again? This article discusses film curation strategies for early, silent, and pre-Code cinema, with the aim of foregrounding women’s film history: attracting new audiences to works with unexpected historical contexts. It suggests that early film history can be reconceptualized as “young cinema,” an era of experimentation, innovation, and excitement in the potentiality of the medium, rather than ossified as “old cinema” with the attendant connotations of the canon, overfamiliarity, and perceived irrelevance.
circ_0134120: a new frontier in understanding postmenopausal osteoporosis pathogenesis
Authors: Wang Junling , Zhang Hongyan , Cao Yue , Ma Irene , Liang Xuefang , Xiang Dongfang
Published: April 2024

Postmenopausal osteoporosis (OP) is a prevalent skeletal disease with not fully understood molecular mechanisms. This study aims to investigate the role of circular RNA (circRNA) in postmenopausal OP and to elucidate the potential mechanisms of the circRNA–miRNA–mRNA regulatory network. We obtained circRNA and miRNA expression profiles from postmenopausal OP patients from the Gene Expression Omnibus database. By identifying differentially expressed circRNAs and miRNAs, we constructed a circRNA–miRNA–mRNA network and identified key genes associated with OP. Further, through a range of experimental approaches, including dual-luciferase reporter assays, RNA pull-down experiments, and qRT-PCR, we examined the roles of circ_0134120, miR-590-5p, and STAT3 in the progression of OP. Our findings reveal that the interaction between circ_0134120 and miR-590-5p in regulating STAT3 gene expression is a key mechanism in OP, suggesting the circRNA–miRNA–mRNA network is a potential therapeutic target for this condition.
2009–2010 metais Klasikinės filologijos katedros dėstytojų išleistos knygos
Authors: Pavardenis Vardenis
Published: April 2024

...
A Comprehensive Analysis of Sports Nutrition Knowledge and Diet Diversity Among South Indian Athletes
Authors:   SRM Medical College Hospital and Research Centre, SRMIST, laavanya Sai , Kumbamoorthy Silambu selvi ,   SRM Medical College Hospital and Research Centre, SRMIST
Published: April 2024

Purpose. Athletes can benefit greatly from having knowledge about sports nutrition. However, there are limited studies on athletes' nutritional knowledge and dietary habits in South India. This study aims to assess the athletes' sports nutrition knowledge, analyse their dietary practices and attitudes, and the dietary diversity score. Material & Methods. A descriptive cross sectional study was conducted in selected areas of Chengalpattu district in Tamil Nadu. Eighty-five athletes aged 10-18 training in different sports academies were interviewed individually using a validated questionnaire to analyse their sports nutrition knowledge, attitude and dietary practices. Results. The results showed that only 4.7% of the athletes had adequate nutritional knowledge of over 60%. The mean overall knowledge score was 40.2%, with athletes being most knowledgeable about protein and its sources (mean score of 67.9%), but less aware of carbohydrate and fat sources and recommendations (mean score of 15.08% and 14.01%, respectively). The mean score for attitude and dietary practices were 64.4 and 59.5 respectively. A strong and positive correlation was found between the level of nutritional knowledge and attitude (p=0.0001). Additionally, we found that the occupation of parents and the monthly income of the family were significantly associated with the athletes' nutritional knowledge. Majority of athletes (74.1%) of the athletes had an adequate dietary diversity score (DDS) of ≥ 5, and 25.9% of the athletes had a DDS of ≤ 4. Conclusions. Nutritional educational interventions at the grass root level can potentially improve athletes' knowledge, dietary practices and sports performance in the future. It is crucial to identify and address knowledge gaps, and use technology to monitor and motivate athletes towards consistency in implementing their knowledge.
Vision Management in Adolescents with Visually Impaired: The Effect of Yogic Visual Concentration
Authors:   Pondicherry University, Kabeer Dilshith Azeezul , Mathavan Binthu ,   Central University of TamilNadu, Kumar Pankaj ,   Central University of Punjab, Bathinda, Cherappurath Nafih ,   Amal College of Advanced Studies, W Vinu ,   Pondicherry University
Published: April 2024

According to World Health Organization (WHO), 314 million individuals worldwide suffer from some degree of vision impairment. Yoga is an effective intervention for the purification and preparation of the body. The leading cleaning practices such as yoga postures, breathing control, and meditation, among others. These techniques include a yogic visual concentration technique known as Trataka. According to certain studies, yogic visual concentration improves eyesight. However, the immediate effect of trataka on visual acuity in adolescents with the visually impaired has not been investigated. Purpose. The present study investigated the effect of 6 weeks of trataka training on visual acuity in visually impaired adolescents. Material & Methods. The study used a single group, before/after design, with ten visually challenged adolescents (Mage=16.5 years; SD=1.5; range 15-18 years) participating in a 6-week trataka training. In clinical settings, the Snellen chart is the most used tool for determining a participant's level of visual acuity. Results. The outcome score for left eyesight (44.44 per cent) and right eyesight (50.43 per cent) improved significantly. Furthermore, paired t-test findings revealed significant improvement in both left eyesight (p<0.001; ES=0.87) and right eyesight (p<0.001; ES=0.83) following 6 weeks of trataka training. Conclusions. The findings of this study objectively show that the yogic visual concentration training may be more effective in adolescents with the visually impaired. Future studies with larger sample size and a more substantial research design based on objective variables are required to strengthen the study's conclusions.
Effect of Twelve-Week Yoga Intervention on Stress and Anxiety in School Going Children
Authors:   University of Delhi, Pradhan Punam , Pramanik Tarak Nath ,   University of Delhi
Published: April 2024

Purpose. The purpose of the study was to examine the effect of twelve-week yogic practices on stress and anxiety in school going male students. Material & Methods. A total of 30 males, aged (15.5±2.40 years) from senior secondary school were selected as subjects. The subjects were divided into two groups of fifteen each (n=15) randomly. The experimental group underwent yogic practices (asanas & pranayamas) for a period of twelve-week and control group followed a normal routine. The training intervention was for forty-five minutes, six days a week. Stress was assessed by the perceived stress scale and anxiety was assessed by Ducklow’s anxiety questionnaire. A pre-post assessment protocol was employed to determine the effect of a twelve-week yogic practice intervention. Results. Unadjusted post hoc comparison between covariate adjusted means revealed a significant difference in anxiety between the experimental, Madj=24.7, SEadj=0.78 and control, Madj=31.70, SEadj=0.78 groups after twelve-week of yoga intervention, p<0.001, d=2.35, 95% CI [3.36, 1.33]. A significant difference was also observed between experimental, Madj=24.5, SEadj=0.43 and control, Madj=26.5, SEadj=0.43 groups in stress after treatment, p=0.004, d=1.15, 95% CI [1.97, 0.33]. Conclusions. Yogic practices (asanas & pranayamas) are beneficial in reducing the stress and anxiety of school going male students. It may be used as a protocol for the maintenance of sound mental health, wellness and fitness.
Hydrolyzable polyphenols contained in extracts from Mentha piperita L. and antioxidant capacity
Authors: Franco Aguirre Yesenia Damaris , Hernández Almanza Ayerim Y , Castañeda Facio Adali Oliva , Herrera Raúl Rodríguez , Ascacio Valdes Juan , Santillán Gerardo de Jesús Sosa , Sáenz Galindo Aide
Published: April 2024

Mentha piperita L., is one of the most popular and consumed species worldwide because of its secondary metabolites with antioxidant properties, among these metabolites are polyphenolic molecules. These molecules can be extracted using different methodologies. However, the range of bioactive compounds in an extract can vary because of different factors, including the extraction methodology. Recently, use of hybrid technologies for extraction of plant compounds has been increased since a empowerment of various properties in the obtained extracts has been demonstrated. In this study was performed an analysis of the polyphenolic compounds and antioxidants from Mentha piperita L. Polyphenolic compounds were extracted using different extraction techniques which are reported as efficient and friendly to the environment, like ultrasound and microwave, which were compared with the hybrid technology (ultrasound-microwave). Results showed a significant increase on the obtaining of hydrolyzable polyphenolic compounds and antioxidant capacity, highlighting that using extraction by a hybrid technique (ultrasound-microwave) showed a greater % yield of extraction compared to ultrasound or microwave used separately.
Classification, main types of structures and purpose of capillary means to ensure fuel perfection
Authors:   Yuzhnoye State Design Office named after M. K. Yangel, Minai O. M.
Published: April 2024

The flight of a spacecraft is characterized by the alternation of active sections of the trajectory, when the propulsion system is operating, and passive sections, in which the liquid components of the fuel in the tanks are under the influence of microgravity and, as a result, various disturbing factors (actions: aerodynamic forces, solar wind, internal gravitational forces, disturbances from the engines of the orientation and stabilization system, etc.) can occupy any position in them. At the same time, the situation is not ruled out when the gas phase can get into the flow line, which in the future can lead to a failure to restart the propulsion system and an emergency end of the mission. Therefore, an almost obligatory element of the systems for storing and supplying liquid rocket fuel components of the propulsion system of a spacecraft is the means of ensuring fuel continuity, the main criterion for the perfection of which is the amount of residual fuel components that cannot be produced due to a violation of the fluid continuity at the inlet to the propulsion system. The design of the fuel continuity means is directly determined by the internal geometry of the tank and the characteristics of the pneumohydraulic system of the spacecraft. A significant complication of the design of the fuel continuity means occurs in the presence of several factors that are present when a spacecraft performs a flight task: multiple launch and stop of the propulsion system, performing complex maneuvers under conditions of multidirectional external force impulses, which is just inherent in spacecraft. The position uncertainty and heterogeneity of the boundaries between the boost gas and fuel components at the time of launching the propulsion system require additional measures to prevent premature gas breakthrough into the flow line with its subsequent entry into the propulsion system. Therefore, over more than five decades, fuel continuity tools have been developed, the operation of which is based on various principles. At the same time, capillary-type fuel continuity means are most widely used. During this time, the basic physical principles of the behavior of a liquid under the action of capillary forces under weightless conditions were studied, the main types of designs of means for ensuring fuel continuity were determined, and the range of tasks they solved was described.
Performance of Febrile Infant Algorithms by Duration of Fever
Authors: Velasco Roberto , Gomez Borja , Labiano Ismael , Mier Ana , Ugedo Alberto , Benito Javier , Mintegi Santiago
Published: April 2024

OBJECTIVES

To analyze the performance of commonly used blood tests in febrile infants ≤90 days of age to identify patients at low risk for invasive bacterial infection (bacterial pathogen in blood or cerebrospinal fluid) by duration of fever.

METHODS

We conducted a secondary analysis of a prospective single-center registry that includes all consecutive infants ≤90 days of age with fever without a source evaluated at 1 pediatric emergency department between 2008 and 2021. We defined 3 groups based on caregiver-reported hours of fever (<2, 2–12, and ≥12) and analyzed the performance of the biomarkers and Pediatric Emergency Care Applied Research Network, American Academy of Pediatrics, and Step-by-Step clinical decision rules.

RESULTS

We included 2411 infants; 76 (3.0%) were diagnosed with an invasive bacterial infection. The median duration of fever was 4 (interquartile range, 2–12) hours, with 633 (26.3%) patients with fever of <2 hours. The area under the curve was significantly lower in patients with <2 hours for absolute neutrophil count (0.562 vs 0.609 and 0.728) and C-reactive protein (0.568 vs 0.760 and 0.812), but not for procalcitonin (0.749 vs 0.780 and 0.773). Among well-appearing infants older than 21 days and negative urine dipstick with <2 hours of fever, procalcitonin ≥0.14 ng/mL showed a better sensitivity (100% with specificity 53.8%) than that of the combination of biomarkers of Step-by-Step (50.0% and 82.2%), and of the American Academy of Pediatrics and Pediatric Emergency Care Applied Research Network rules (83.3% and 58.3%), respectively.

CONCLUSIONS

The performance of blood biomarkers, except for procalcitonin, in febrile young infants is lower in fever of very short duration, decreasing the accuracy of the clinical decision rules.
Safety and Efficacy of Percutaneous Pulmonary Valve Implantation: The Singapore Experience
Authors: Lim Fang Yi , Foo Jie Sheng , Yap Jonathan , Lee Phong Teck , Sundararaghavan Sreekanthan , Tan Ju Le
Published: April 2024

Background: Right ventricular outflow tract (RVOT) dysfunction in adult congenital heart disease patients frequently requires repeated interventions. Percutaneous pulmonary valve implantation (PPVI) is being used increasingly to treat pulmonary stenosis (PS) and regurgitation (PR), improving symptoms, right ventricular haemodynamics and function and, indirectly, left ventricular filling and function. This article explores the authors’ early local experience with PPVI. Methods: Between 2017 and 2022, PPVI was attempted in 10 patients at a single tertiary centre, including six with PS and four with PR. Patients underwent multimodality imaging and dental clearance. PPVI was then performed. Patients were continued on lifelong single antiplatelet therapy and dental hygiene was reinforced. Results: Overall, there was an 80% success rate of Melody PPVI in the 10 adult congenital heart disease (ACHD) patients (mean age 35.8 ± 13.7 years; 60% male), with significant improvements in RVOT pathology, right ventricle function and pulmonary pressures. Melody PPVI was cancelled in one patient due to risk of coronary compression, and an Edwards S3 PPVI was implanted in another patient instead due to a large RVOT size causing stent embolisation. Two patients experienced complications of bleeding and stent fracture, both of which were conservatively managed and had good long-term outcomes. Conclusion: The authors present their early local experience with PPVI in ACHD patients at a single tertiary centre. PPVI has proven to be safe and efficacious, improving PS and PR, right and left ventricle function and pulmonary pressures. Nonetheless, precautions must be taken to minimise complications such as coronary compression, access site bleeding, device embolisation and stent fracture.
Азербайджанська весільна церемонія: традиції та символіка
Authors: Хамзаєва Нурлана
Published: April 2024

У статті «Азербайджанська весільна церемонія: традиції та символіка» досліджується багата культурна спадщина весільних церемоній в Азербайджані, розкриваються її традиційні елементи та символіка. Автор детально розглядає різні аспекти весільного обряду, починаючи з попередньої підготовки і закінчуючи подальшими звичаями, простежуючи вплив історичних, релігійних та культурних чинників на формування цих традицій. У статті також звертається увага на символічне значення різних елементів весільного обряду, таких як прикраси, костюми, музичні композиції та ритуальні дії, а також їх роль у збереженні та передачі культурної спадщини. Дослідження базується на аналізі джерел, інтерв'ю з представниками азербайджанської громади та спостереженнях за сучасною весільною практикою. Результати роботи допомагають краще зрозуміти багатство і глибину азербайджанських весільних традицій і їх роль у формуванні культурної самосвідомості народу.

Актуальність вивчення азербайджанського весільного обряду є актуальним в сучасному контексті, так як це допоможе більш глибоко зрозуміти і проникнути в дух місцевого народу. Виявити традиції та символи, пов'язані з цим обрядом, має важливе значення для збереження культурної спадщини Азербайджану та його представлення перед світловим співтовариством.

Метою статті є вивчення азербайджанського весільного обряду з основним акцентом на традиціях і символах, щоб виявити їх значення і сенс.

Результати дослідження виявило основні особливості азербайджанського весільного обряду, включаючи традиції та символи. Було проведено історичне дослідження, засноване на літературних та архівних джерелах, а також зібрані дані з сучасних весільних церемоній.

Висновки вивчення азербайджанського весільного обряду дозволяють зрозуміти його величезне значення для місцевого населення. Важливо зберігати і продовжувати традиції і символи, пов'язані з цим обрядом, щоб зберегти культурну спадщину Азербайджану і передати його майбутнім поколінням. Усвідомлення і повага до цих традицій і символів допомагають зміцнити національну ідентичність і згуртувати народ.
Концепція «Новоросії» на тлі ранньомодерних експансіоністських доктрин Московії та просторових уявлень українських еліт
Authors: Брехуненко Віктор
Published: April 2024

У статті досліджується проблема інтелектуальних перегуків між концепцією «Новоросії» та попередніми російськими експансіоністськими доктринами.

Мета дослідження полягає у з’ясуванні ступеня закоріненості концепції «Новоросії» в ранньомодерних поясненнях російської експансії на українські землі.

Методологія дослідження охоплює методи контекстуального аналізу, компаравістики, деконструкції текстів, історико-генетичний.

Наукова новизна дослідження полягає насамперед у доведенні того, що концепція Новоросії», яка з’явилася в 30-40-х рр. ХІХ ст., не має прямих генетичних попередників у ранньомодерних російських обґрунтуваннях «історичних прав» на відповідну частину української території.

Результати. Територія, яку штучно підводять під означення «Новоросія», до ХІХ ст. не розглядалася в Московській державі / Російській імперії під кутом конструювання для неї опції природного компонента «царської отчини». Ідеологічне привласнення регіону відбувалося на принципово інших засадах, ніж це пізніше прописали в концепції «Новоросії». Більше того, на рівні царських грамот визнавалася належність території, включно з Чорноморським узбережжям, до просторового виміру Війська Запорозького. У другій половині XVIII ст. російські еліти послідовно розглядали цю територію як органічну складову Малої Росії. На обшири умоглядної «Новоросії» не поширювали династичну теорію. Не розробляли і спеціальних ідеологічних конструкцій.  

Висновки. Ідеологічна концепція «Новоросії» була штучним витвором навіть для російської інтелектуальної традиції, не відображала спадкоємність обґрунтування просторових претензій у її звичному полі з ранньомодерних часів.  На рівні уявлень та ідей опрацювання концепції започатковувало цілком нові підходи до маркування території сучасних Південної та Східної України.