bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Effect of AqueousMomordica charantiaLinn. Extract on Zebrafish Embryo Model through Acute Toxicity Assay Assessment
Authors: Thiagarajan Siroshini K. , Rama Krishnan Khamini , Ei Thandar , Husna Shafie Nurul , Arapoc Daryl J. , Bahari Hasnah
Published: May 2019

Momordica charantiaLinn., commonly known as bitter gourd, has many protective roles due to its medicinal value as it contains bioactive components. However, this extract showed possible toxicity effect on zebrafish embryo. Thus this study was designed to differentiate the toxicity activities in two types ofM. charantiasample which are Indian and ChineseM. charantia, as well as to compare between two different aqueous extraction methods, hot and cold aqueous method, using zebrafish embryo assay assessment. It was observed that the survival rate of zebrafish embryo decreased as the concentration of test extract increased for all samples ofM. charantia. The LC50values of hot aqueous ChineseM. charantia, hot aqueous IndianM. charantia, and cold aqueous ChineseM. charantiawere 144.54μg/ml, 199.53μg/ml, and 251.19μg/ml, respectively. However, cold aqueous IndianM. charantiahas a higher LC50which was not in the range of the tested concentration. Hatchability ofDanio rerioembryo reduced as the concentration ofM. charantiaextract increased while no hatching was observed in the highest concentration (1000μg/ml). Scoliosis of zebrafish larvae was only seen in higher concentrations (125-1000μg/ml) of extract. The heartbeat of zebrafish larvae treated withM. charantiaextract was within the normal range, 120-180 bpm, but at higher concentrations (125-1000μg/ml) the heartbeat differed for all samples of test extract. Hence, although this plant extract was safe to be consumed due to its pharmaceutical effect, it still exhibited mild toxicity effect at higher concentration when it was evaluated on zebrafish embryo.
Effects of In-Vehicle Navigation on Perceptual Responses and Driving Behaviours of Drivers at Tunnel Entrances: A Naturalistic Driving Study
Authors: Fu Xinsha , He Shijian , Du Jintao , Ge Ting
Published: May 2019

The perceptual responses and driving behaviours of drivers at tunnel entrances vary, which could cause interference and accidents. This study investigated the effects of in-vehicle navigation on the perceptual responses and driving behaviours and whether these effects are actually valid for safety improvement. For this purpose, a series of naturalistic driving experiments was conducted and a comparative analysis was performed considering two different experiment conditions, control condition and in-vehicle navigation condition. Under each condition, the performances of twenty drivers at seven tunnels were evaluated. The area from 200 m outside the tunnel portal to 200 m inside the tunnel portal was averagely divided into four zones. In each zone, two types of perceptual responses (visual responses and psychological responses) and driving behaviours were analysed using six indicators: number of fixations, average duration of fixations, time interval between continuous R-waves, skin conductance response, speed difference in zones, and maximum deceleration. The results showed that in-vehicle navigation significantly affects the perceptual responses and driving behaviours of drivers, and these effects varied in different zones of the tunnel entrance. Furthermore, in-vehicle navigation was found to be valid for safety improvement because beneficial changes in four of the six indicators proved to be effective at appropriate zones. The remaining two indicators, average duration of fixations and maximum deceleration, were not valid, implying that the difficulty of driving information cognition and driving comfort could not be improved by in-vehicle navigation. Moreover, a negative correlation was discovered between the number of fixations and speed difference in zones. This study provides engineers a new knowledge by extending the quantifiable approaches to the analyses of the effectiveness of the effects of in-vehicle navigation.
Interrelationships of Pressure-Dependent Hole Fraction and Elongational Viscosity in Polymer Melts
Authors: Sahin-Dinc Fatma , Yahsi Ugur , Sedlacek Tomas
Published: May 2019

The elongational flow behavior of polyethylene, polypropylene, polystyrene, poly(methyl methacrylate), and polycarbonate, temperatures from 70 to 290 °C and pressures up to 70 MPa, is examined with the Yahsi-Dinc-Tav (YDT) model and its particular case known as the Cross model. The viscosity data employed in the range of 3-405 s-1 elongational rates were acquired from the literature at ambient and elevated pressures. The predictions and the fitting results of the proposed YDT model with the same measurement data are compared with the Cross model. The average absolute deviations of the viscosities predicted by the YDT model range from 0.54% to 9.44% at ambient and 1.95% to 6.28% at high pressures. Additionally, the linear formulations derived from the YDT model are employed to relate the viscosity with temperature and hole fraction (“thermooccupancy” function) at zero level of elongational rate and constant elongational rate along with constant elongational stress. The effects of the four viscosity parameters (such as transmission and activation energy coefficients in these equations) on the elongational viscosity are analyzed in detail and some conclusions on the structural differences for the polymers are discussed.
Research on Coal-Rock Fracture Image Edge Detection Based on Tikhonov Regularization and Fractional Order Differential Operator
Authors: Liu Chunsheng , Ren Chunping
Published: May 2019

Aiming at the conventional image edge detection algorithm, the first-order differential edge detection method is easy to lose the image details and the second-order differential edge detection method is more sensitive to noise. To deal with the problem, the Tikhonov regularization method is adopted to reconstruct the input coal-rock infrared images, so as to reduce the noise interference, and then, the reconstructed image is transformed by gray level. Finally, we consider the frequency characteristics and long memory properties of fractional differential, the classical first-order Sobel and second-order Laplacian edge detection algorithms are extended to fractional order pattern, and a new pattern of fractional order differential image edge detection is constructed to realize the coal-rock fracture edge features identification. The results show that, compared with integer order differential, the error rate and omission rate of fractional order differential algorithm are smaller, the quality factor is larger, and the execution time and memory footprint are smaller. From the point of view of location criteria and location accuracy, the fractional order differential algorithm is better than the integer order. In addition, the proposed method is compared with Canny algorithm, B-spline wavelet transform, and multidirection fuzzy morphological edge detection method, can detect more coal-rock fracture infrared image edge details, and is more robust to noise.
An Optimization Method for Operation Adjustment of High-Speed Delayed Trains
Authors: Li Xiaojuan , Huo Yueying , Yan Zhenying , Han Baoming
Published: May 2019

Train delays have a great impact on the schedule of high-speed railways including overall efficiency and the quality of the travel service of the passengers. Therefore, the development of an approach to recover a schedule via timely and rapid operation adjustments must be investigated. In this paper, a complete final real-time adjustment scheme is proposed for the train dispatcher of a railway enterprise for delayed trains. A train operation process model based on the Max-Plus algebra method is proposed. Six operation adjustment strategies are analyzed including section acceleration, operation based on the original timetable, dwell time reduction, increase in overtaking, reduction in overtaking, and train postponement. An approximate model is then built based on the minimum number of delayed trains considering the constraints of the adjustment strategies and the feasible adjusted schemes can be quickly obtained without any record specific time data and constraints. The set of feasible solutions of the approximate model is then regarded as the importation of the second model. In addition, the second model is an optimization model for operation adjustment with the least average delay time of each train at each station by updating the state matrixes of the train operation process model. The algorithms are designed for these models, and this approach can reduce the computation time. Finally, the timetable of the Beijing-Shanghai high-speed railway is considered as the actual case for analysis. Thus, the method was proven feasible for operation adjustment of delayed trains.
A Multigene Assay Determines Risk of Recurrence in Patients with Triple-Negative Breast Cancer
Authors: Stewart Rachel L. , Updike Katherine L. , Factor Rachel E. , Henry N. Lynn , Boucher Kenneth M. , Bernard Philip S. , Varley Katherine E.
Published: May 2019

Approximately 40% of patients with stage I–III triple-negative breast cancer (TNBC) recur after standard treatment, whereas the remaining 60% experience long-term disease-free survival (DFS). There are currently no clinical tests to assess the risk of recurrence in TNBC patients. We previously determined that TNBC patients with MHC class II (MHCII) pathway expression in their tumors experienced significantly longer DFS. To translate this discovery into a clinical test, we developed an MHCII Immune Activation assay, which measures expression of 36 genes using NanoString technology. Preanalytical testing confirmed that the assay is accurate and reproducible in formalin-fixed paraffin-embedded (FFPE) tumor specimens. The assay measurements were concordant with RNA-seq, MHCII protein expression, and tumor-infiltrating lymphocyte counts. In a training set of 44 primary TNBC tumors, the MHCII Immune Activation Score was significantly associated with longer DFS (HR = 0.17; P = 0.015). In an independent validation cohort of 56 primary FFPE TNBC tumors, the Immune Activation Score was significantly associated with longer DFS (HR = 0.19; P = 0.011) independent of clinical stage. An Immune Activation Score threshold for identifying patients with very low risk of relapse in the training set provided 100% specificity in the validation cohort. The assay format enables adoption as a standardized clinical prognostic test for identifying TNBC patients with a low risk of recurrence. Correlative data support future studies to determine if the assay can identify patients in whom chemotherapy can be safely deescalated and patients likely to respond to immunotherapy.

Significance:

The MHCII Immune Activation assay identifies TNBC patients with a low risk of recurrence, addressing a critical need for prognostic biomarker tests that enable precision medicine for TNBC patients.
A Novel Fully Human Antibody targeting Extracellular Domain of PSMA Inhibits Tumor Growth in Prostate Cancer
Authors: Wu Jieheng , Han Donghui , Shi Shengjia , Zhang Qiang , Zheng Guoxu , Wei Ming , Han Yueheng , Li Guodong , Yang Fa , Jiao Dian , Xie Pin , Zhang Lingling , Yang An-Gang , Zhao Aizhi , Qin Weijun , Wen Weihong
Published: May 2019

Prostate cancer is the most commonly diagnosed malignancy in men and the second leading cause of cancer-related death. It is of vital importance to develop new strategies for prostate cancer therapy. PSMA (prostate-specific membrane antigen) is specifically expressed in prostate cancer and the neovasculature of certain cancer types, thus is considered to be an ideal target for cancer therapy. In our previous study, we have obtained a PSMA-specific single-chain variable fragment (scFv), named gy1, from a large yeast display naïve human scFv library. In this study, we reconstructed the PSMA scFv into a fully human antibody (named PSMAb) and evaluated its characterization both in vitro and in vivo. We showed that PSMAb can specifically bind with and internalize into PSMA+ cells. The binding affinity of PSMAb is measured to be at nanomolar level, and PSMAb has very good thermostability. In vivo study showed that near IR dye–labeled PSMAb can specifically localize at PSMA+ tumors, and the application of PSMAb in vivo significantly inhibited the growth of PSMA+ tumors, but not PSMA− tumors. At the studied doses, no obvious toxicity was observed when applied in vivo, as shown by the relative normal liver and kidney function and normal structure of important organs, shown by hematoxylin and eosin staining. In addition, PSMAb may inhibit tumor growth through antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity mechanisms. Our results indicated that the novel fully human antibody, PSMAb, deserve further study for PSMA-targeted diagnosis and therapy for prostate cancer and other cancer types with vascular PSMA expression.
Prediction Model of Cardiac Risk for Dental Extraction in Elderly Patients with Cardiovascular Diseases
Authors: Tang Min , Hu Ping , Wang Cao-Feng , Yu Chuang-Qi , Sheng Jing , Ma Shao-Jun
Published: May 2019

Background: With the rapidly increasing population of elderly people, dental extraction in elderly individuals with cardiovascular diseases (CVDs) has become quite common. The issue of how to assure the safety of elderly patients with CVDs undergoing dental extraction has perplexed dentists and internists for many years. And it is important to derive an appropriate risk prediction tool for this population. Objectives: The aim of this retrospective, observational study was to establish and validate a prediction model based on the random forest (RF) algorithm for the risk of cardiac complications of dental extraction in elderly patients with CVDs. Methods: Between August 2017 and May 2018, a total of 603 patients who fulfilled the inclusion criteria were used to create a training set. An independent test set contained 230 patients between June 2018 and July 2018. Data regarding clinical parameters, laboratory tests, clinical examinations before dental extraction, and 1-week follow-up were retrieved. Predictors were identified by using logistic regression (LR) with penalized LASSO (least absolute shrinkage and selection operator) variable selection. Then, a prediction model was constructed based on the RF algorithm by using a 5-fold cross-validation method. Results: The training set, based on 603 participants, including 282 men and 321 women, had an average participant age of 72.38 ± 8.31 years. Using feature selection methods, 11 predictors for risk of cardiac complications were screened out. When the RF model was constructed, its overall classification accuracy was 0.82 at the optimal cutoff value of 18.5%. In comparison to the LR model, the RF model showed a superior predictive performance. The AUROC (area under the receiver operating characteristic curve) scores of the RF and LR models were 0.83 and 0.80, respectively, in the independent test set. The AUPRC (area under the precision-recall curve) scores of the RF and LR models were 0.56 and 0.35, respectively, in the independent test set. Conclusion: The RF-based prediction model is expected to be applicable for preoperative clinical assessment for preventing cardiac complications in elderly patients with CVDs undergoing dental extraction. The findings may aid physicians and dentists in making more informed recommendations to prevent cardiac complications in this patient population.
Simple Anatomical Calculations Possibly As Accurate As Three-Dimensional Lobar Quantification with SPECT-CT in Predicting Lung Function after Pulmonary Resection
Authors: Simon Donald , Irusen Elvis M. , Warwick James M. , Doruyter Alex , Koegelenberg Coenraad F.N.
Published: May 2019

The estimation of predicted postoperative (PPO) lung function is important in lung resection candidates. We utilized simple anatomical calculations and single-photon emission computed tomography combined with computed tomography (SPECT-CT) to calculate PPO in 24 consecutive patients with impaired pulmonary function who underwent lung resection. PPO values calculated by anatomical calculations and three-dimensional lobar SPECT-CT quantification both correlated well with the postoperative forced expiratory volume in 1 s, with r = 0.825, p < 0.001 and r = 0.796, p < 0.001, respectively. Both techniques fared well at predicting postoperative lung function, but our observations unexpectedly suggested that simple anatomical calculations might be equivalent to three-dimensional SPECT-CT lobar quantification.
Investigation of an Outbreak of Dengue Virus Serotype 1 in a Rural Area of Kribi, South Cameroon: A Cross-Sectional Study
Authors: Nemg Simo Fredy Brice , Sado Yousseu Francine Berlange , Evouna Mbarga Armel , Bigna Jean Joel , Melong Armel , Ntoude Anicet , Kamgang Basile , Bouyne Raphael , Moundipa Fewou Paul , Demanou Maurice
Published: May 2019

Background: On May 2017, a case of dengue serotype 1 was detected and confirmed through routine surveillance in a traveler returning from Kribi, a seaside town of Southern Cameroon. This study aimed at confirming the circulation of dengue virus (DENV) in Southern Cameroon. Methods: A cross sectional study was carried out in Londji near Kribi from June 21–25, 2017, by a joint team of Centre Pasteur of Cameroon and the Department of Diseases, Epidemics and Pandemics Control. Blood samples of consented participants were collected and tested for anti-D ENV IgM using an IgM antibody capture enzyme-linked immunosorbent assay (MAC-ELISA), and for the detection of Zika, dengue, or chikungunya viruses using Trioplex real-time reverse transcription-polymerase chain reaction (RT-PCR). DENV RNA-positive samples were serotyped using an end-point nested RT-PCR. Results: Ninety-one participants were enrolled, 50.55% (46/91) of them males. The mean age of the population was 30.71 years (±18.89). In total, 14.28% (13/91) of the participants had DENV infection (3 anti-DENV IgM positive and 10 DENV serotype 1 RT-PCR positive). Conclusion: The detection of DENV serotype 1 in an autochthonous population during this survey is a confirmation that the seaside city of Kribi is a risk area for contracting dengue infection in Cameroon.
Guia do acervo MAC USP
Authors:   Universidade de São Paulo. Museu de Arqueologia e Etnologia
Published: May 2019

O Guia apresenta uma história sobre a formação do acervo MAC USP, desde o núcleo fundador doado por Francisco Matarazzo Sobrinho até a incorporação da arte digital no acervo museológico. Comentários são tecidos sobre doze artistas identificados como destaques do acervo, seguidos de uma listagem ilustrada de obras divididas em duas partes: obras pertencentes à primeira metade do século XX e obras da segunda metade do século XX.
Membrane Lipid-K
IR
2.x Channel Interactions Enable Hemodynamic Sensing in Cerebral Arteries
Authors: Sancho Maria , Fabris Sergio , Hald Bjorn O. , Brett Suzanne E. , Sandow Shaun L. , Poepping Tamie L. , Welsh Donald G.
Published: May 2019

Objective—

Inward rectifying K
+
(K
IR
) channels are present in cerebral arterial smooth muscle and endothelial cells, a tandem arrangement suggestive of a dynamic yet undiscovered role for this channel. This study defined whether distinct pools of cerebral arterial K
IR
channels were uniquely modulated by membrane lipids and hemodynamic stimuli.

Approach and Results—

A Ba
2+
-sensitive K
IR
current was isolated in smooth muscle and endothelial cells of rat cerebral arteries; molecular analyses subsequently confirmed K
IR
2.1/K
IR
2.2 mRNA and protein expression in both cells. Patch-clamp electrophysiology next demonstrated that each population of K
IR
channels was sensitive to key membrane lipids and hemodynamic stimuli. In this regard, endothelial K
IR
was sensitive to phosphatidylinositol 4,5-bisphosphate content, with depletion impairing the ability of laminar shear stress to activate this channel pool. In contrast, smooth muscle K
IR
was sensitive to membrane cholesterol content, with sequestration blocking the ability of pressure to inhibit channel activity. The idea that membrane lipids help confer shear stress and pressure sensitivity of K
IR
channels was confirmed in intact arteries using myography. Virtual models integrating structural/electrical observations reconceptualized K
IR
as a dynamic regulator of membrane potential working in concert with other currents to set basal tone across a range of shear stresses and intravascular pressures.

Conclusions—

The data show for the first time that specific membrane lipid-K
IR
interactions enable unique channel populations to sense hemodynamic stimuli and drive vasomotor responses to set basal perfusion in the cerebral circulation.
Effects of Arteriovenous Fistula Ligation on Cardiac Structure and Function in Kidney Transplant Recipients
Authors: Rao Nitesh N. , Stokes Michael B. , Rajwani Adil , Ullah Shahid , Williams Kerry , King David , Macaulay Ewan , Russell Christine H. , Olakkengil Santosh , Carroll Robert P. , Faull Randall J. , Teo Karen S.L. , McDonald Stephen P. , Worthley Matthew I. , Coates P. Toby
Published: May 2019

Background:

Cardiovascular morbidity and mortality remain high in recipients of a kidney transplant. The persistence of a patent arteriovenous fistula (AVF) after transplantation may contribute to ongoing maladaptive cardiovascular remodeling. The ability to reverse this maladaptive remodeling by ligation of this AVF is unknown. We conducted the first randomized controlled trial to evaluate the effect of AVF ligation on cardiac structure and function in stable kidney transplant recipients.

Methods:

In this randomized controlled trial, kidney transplant recipients (>12 months after transplantation with stable graft function) were randomized to AVF ligation or no intervention. All participants underwent cardiac magnetic resonance imaging at baseline and at 6 months. The primary outcome was the change in left ventricular (LV) mass. Secondary outcomes included changes in LV volumes, left and right atrial areas, LV ejection fraction, NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, cardiac output/index, brachial flows (ipsilateral to AVF), and pulmonary artery velocity.

Results:

A total of 93 patients were screened, of whom 64 met the inclusion criteria and were randomized to the AVF ligation (n=33) or control (n=31) group. Fifty-four participants completed the study: 27 in the AVF ligation group and 27 in the control group. On the second cardiac magnetic resonance scan, a mean decrease of 22.1 g (95% CI, 15.0–29.1) was observed in LV mass in the AVF ligation group compared with a small increase of 1.2 g (95% CI, −4.8 to 7.2) in the control group (
P
<0.001). Significant decreases in LV end-diastolic volumes, LV end-systolic volumes, cardiac output, cardiac index, atrial volumes, and NT-proBNP were also seen in the AVF closure group (
P
<0.01). No significant changes were observed in LV ejection fraction (
P
=0.93) and pulmonary artery velocity (
P
=0.07). No significant complications were noted after AVF ligation. No changes in estimated glomerular filtration rate or systolic and diastolic blood pressures were observed between cardiac magnetic resonance scans.

Conclusions:

Elective ligation of patent AVF in adults with stable kidney transplant function resulted in clinically significant reduction of LV myocardial mass.

Clinical Trial Registration:

Australian and New Zealand Clinical Trials Registry URL:
https://www.anzctr.org.au
. Unique Identifier: ACTRN12613001302741.
How Does Culture Shape Conceptions of Forgiveness? Evidence From Japan and the United States
Authors: Joo Minjoo , Terzino Kari A. , Cross Susan E. , Yamaguchi Naomi , Ohbuchi Ken-ichi
Published: May 2019

Theories of culture, cognition, and social relations suggest there may be differences in conceptions of forgiveness between the members of East Asian and Western cultures, but few researchers have examined this issue. This article builds on previous research on prototypes of forgiveness in the United States to address the question “What is forgiveness?” in Japan. In Studies 1a and 1b, we investigated Japanese conceptions of forgiveness. Study 2 demonstrated that forgiveness features that U.S. and Japanese participants generated are meaningfully different. Compared with Americans, Japanese participants focused more on aspects related to relationship harmony; they seemed to emphasize an adjustment motive and decisional forgiveness. They also put less emphasis on emotional forgiveness and attention to individuals in comparison with Americans. Our results suggest that the high value placed on relationship maintenance in Japan leads to different understandings of forgiveness. Inclusion of culturally diverse conceptions into the definition of forgiveness aids further understanding of forgiveness, which, in turn, enhances the development and application of existing theories.
Making Sense of Chinese Employees’ Suicide Ideation: Does Meaning in Life Matter?
Authors: Liu Yuxin , Usman Muhammad , Zhang Jianwei , Raza Jamshed , Gul Habib
Published: May 2019

Drawing on the self-determination theory and conservation of resources, our research shed light on the linkage between organizational autonomy support and suicide ideation. Specifically, this study examined whether the negative influence of autonomy support on suicide ideation is mediated via meaning in life, and if employee’s autonomy orientations constitute a boundary condition of this relationship. To test the hypothesized model, data were collected from professional employees ( N = 687) across six organizations of various business sectors. The findings supported our proposed hypotheses and showed that individuals’ meaning in life mediated the linkage between autonomy support and suicide ideation. As suggested, hypothesized relations were moderated by employee’s disposition in such a way that autonomy support influences meaning in life of employees high on autonomy orientation, but not of employees low on autonomy orientation. The study discussed implications and future research avenues.
Cluster Analysis of the Child Behavior Checklist 1.5–5 for Preschool Children Diagnosed With a Mental Disorder
Authors: Kim Ji Ye , Ha Eun Hye
Published: May 2019

Research on the relationship between the Child Behavior Checklist (CBCL) and Diagnostic and Statistical Manual for Mental Disorder diagnoses for preschool children is scarce. Cluster analysis can be useful for investigating characteristics of a clinical group by using CBCL subscales and classifying subtypes of a Diagnostic and Statistical Manual for Mental Disorder diagnosis group. This study conducted a cluster analysis of the CBCL 1.5–5 for preschool children diagnosed with a mental disorder. Participants were 333 children (255 males and 78 females) aged 1.5 to 5 years who were diagnosed with a mental disorder. The CBCL 1.5–5 and Bayley Scales of Infant Development II were used as assessment instruments. Three clusters were extracted and then compared with CBCL 1.5–5 profiles of each Diagnostic and Statistical Manual for Mental Disorder-5 subject group to determine their clusters. Cluster 1 was named “intellectual disorder cluster.” Cluster 2 was referred to as “other mental disorders cluster,” and Cluster 3 was called “autism spectrum disorder cluster.” When differences in profiles of behavior problems distinguished by CBCL 1.5–5 scales were examined among different clusters, discriminant validity was found to be high.
Exploring the theories, determinants and policy options of street vending: A demand-side approach
Authors: Igudia Eghosa O
Published: May 2019

Street vending has become an increasingly common feature of urban centres for several decades, with a relatively high proportion of developing countries’ populations depending on it for employment, income or survival. Taking a supply-side approach, studies have shown that the responses of urban planners to street vending have followed the modernism theory. In this paper, we take a demand-side (buyer-focused) approach to studying street vending, which has received little attention to date from the academic community. Employing data from Lagos state, Nigeria, we report four explanations underpinning the demand side of street vending: formal economy failures, social/redistributive explanations, financial gains and a multifeature explanation. These are, in turn, explained by the marital status, level of education and perception of individuals. Our findings highlight the need for urban planners to embrace pragmatic policies in addressing these demand-side drivers of street vending and use of urban space, rather than criminalising its actors.
Saving Europe in Spain: José Ortega y Gasset’s Meditations on Quixote and the politics of self, nation and Europe
Authors: Mann Peter Gordon
Published: May 2019

This article examines the Spanish and German contexts of philosopher José Ortega y Gasset’s Europeanizing cultural mission before the First World War, culminating in his first published book Meditations on Quixote (1914). Ortega saw in the genius of Cervantes’ Don Quixote both a source of latent European cultural ideals preserved in Spain’s past and an exemplar of tragicomic heroism fit to defend these ideals in the face of twentieth-century modernity. Using Georg Simmel’s concept of ‘the tragedy of culture’ as a way to give shape to the problem of decadence and the idea of cultural salvation in Spain and Europe in and around 1914, I show how Ortega seized on the German ideal of Bildung as the European cultural ideal to regenerate Spain, after which Spain would save Europe. Here the idea of Europe served as both the vehicle and the aim of cultural salvation. By analysing Ortega’s project of overcoming decadence and saving culture in the decade leading up to the war, I show how the discourse of European identity took shape in relation to the search for the authentic identities of self and nation.
Analysing Paul’s Reference to Baptism in Galatians 3.27 through Studies of Memory, Embodiment and Ritual
Authors: Yuh Jason N.
Published: May 2019

Despite the scholarly consensus regarding the logical importance of Paul’s reference to baptism in Gal. 3.27, there has been hardly any sustained analysis of why such a brief reference could be effective. With the recent emergence of interdisciplinary methods from cognitive science, memory studies, notions of embodiment, and ritual theories, this study explores the social impact of Paul’s reference to baptism. Paul simultaneously reinforces his authority over, and solidarity with, the Galatian communities in a ‘misrecognized’ manner – neither of which could be claimed by the ‘agitators’ against whom he is arguing.
Examining the Association Between Personal Victimization in Adolescence and Intimate Partner Victimization in Adulthood
Authors: Rima Dzhansarayeva , Gulnar Zhandykeyeva , Batyrbek Shopabayev , Orynbassar Tlepbergenov , Beaver Kevin M.
Published: May 2019

A large body of research has examined various issues related to repeat victimization, including potential risk factors and theoretical explanations. Despite the amount of studies dedicated to focusing on repeat victimization, there are some notable gaps in the literature. One particularly noteworthy omission in this research is whether there is a link between personal victimization in adolescence and intimate partner violence (IPV) victimization in adulthood. The current study sought to address this gap. To do so, data drawn from the National Longitudinal Study of Adolescent to Adult Health were analyzed. The results revealed a statistically significant and relatively consistent association between personal victimization in adolescence and IPV victimization in adulthood. This association was detected for both males and females, and it was detected even after controlling for low self-control (males and females) and being the perpetrator of IPV (males). We conclude by noting some of the implications of these findings, as well as limitations to the study that need to be addressed in the future.
School librarians in Sweden: A case study in change
Authors: Farmer Lesley S. J.
Published: May 2019

This study reveals the complexities and dynamics of law, governance, and practice that have impacted school libraries in Sweden. The Education Act of 2010 and the Swedish Library Act of 2013, which mandated school libraries, did not address staffing, and that loophole has been given recent attention, especially in light of national curriculum changes and librarian shortages. The University of Borås’s School of Library and Information Science is the largest, leading institution within Sweden for preparing professional librarians. Their school librarianship faculty is in the process of changing its curriculum. This paper explains the school librarianship situation in Sweden as a case study of a change process in the profession.
Benefits and Risks of Truck Platooning on Freeway Operations Near Entrance Ramp
Authors: Wang Meng , van Maarseveen Sander , Happee Riender , Tool Onno , van Arem Bart
Published: May 2019

Truck platooning attracts considerable attention thanks to the promising fuel consumption benefits and business model. Nevertheless, concerns over the influence of long truck platoons on other traffic are raised by road operators. It is intriguing to understand under what conditions truck platooning will influence other traffic and what are the magnitudes of the influence. To this end, this paper reports a simulation study on examining the effects of truck platooning on freeway operations near an on-ramp. Systematic experiments were conducted with varying demand, market penetration rates (MPRs), intra-platooning gap, and platoon size. Moreover, three alternative strategies for truck platooning to accommodate merging traffic were tested: allowing courtesy lane change of trucks, active yielding, and keeping a larger intra-platoon gap than the acceptable gap for human drivers to change lane. Simulation results show that at high MPRs of truck platooning, the system mitigates congestion and increases throughput, at the expense of merging failures. The merge location distributions shift toward the end of the acceleration lane at congested flow and high MPRs. The effect on average merging speed is insignificant, but the merging speed in saturated traffic with truck platooning shows larger variability. At free flow and low MPRs, the influence is insignificant. Evaluation of the three alternatives concludes that the yielding strategy is most effective in resolving the merging problem with truck platooning. Courtesy lane change is not always possible because of the high speed difference between lanes and keeping a larger time gap suppresses the benefits in congestion mitigation and throughput increase.
Personality Trait Predictive Utility and Stability in Transcranial Magnetic Stimulation (rTMS) for Major Depression: Dissociation of Neuroticism and Self-Criticism: Utilité prédictive et stabilité des traits de personnalité dans la stimulation magnétique transcrânienne répétitive (SMTr) pour la dépression majeure : dissociation du neuroticisme et de l’autocritique
Authors: Kopala-Sibley Daniel C. , Chartier Gabrielle B. , Bhanot Shiv , Cole Jaeden , Chan Peter Y. , Berlim Marcelo T. , McGirr Alexander
Published: May 2019

Background:

Cost-efficient and non-invasive predictors of antidepressant response to repetitive transcranial magnetic stimulation (rTMS) are required. The personality vulnerabilities—neuroticism and self-criticism—are associated with antidepressant outcomes in other modalities; however, self-criticism has not been examined in response to rTMS, and the literature on neuroticism and rTMS is inconsistent.

Methods:

This naturalistic, 4-week study involved daily dorsolateral prefrontal cortex (DLFPC) rTMS for major depression (15 unipolar, 2 bipolar). Participants completed the Big Five Inventory (neuroticism) and the Depressive Experiences Questionnaire (self-criticism) at baseline and at the end of treatment. Changes in depressive symptoms, as rated by the clinician, were quantified using the 21-item Hamilton Depression Rating Scale. Given the inconsistencies in data regarding the stability of neuroticism in patients receiving rTMS, we performed a systematic review and quantitative meta-analysis of trials examining rTMS and neuroticism.

Results:

rTMS significantly improved depressive symptoms, and this was predicted by higher levels of self-criticism but not neuroticism. Self-criticism was stable over the 4 weeks of rTMS; however, neuroticism decreased, and this was not related to decreases in depressive symptoms. Our quantitative meta-analysis of 4 rTMS trials in major depression ( n = 52 patients) revealed decreases in neuroticism, with a moderate effect size.

Limitations:

Our results are limited by a small sample size, and the absence of a sham-rTMS group. Our meta-analysis included only 4 trials.

Conclusion:

Highly self-critical patients appear to benefit more from rTMS than less self-critical patients. Neuroticism, a conceptually similar but distinct personality domain, does not appear to predict antidepressant response, yet this vulnerability factor for depression decreases after rTMS.
The Care for Life Family Preservation Program: Outcome Evaluation of a Holistic Community Development Program in Mozambique
Authors: Panos Angelea , Panos Patrick , Gerritsen-McKane Ruth , Tendai Tiago
Published: May 2019

Objective:

In 2016, Mozambique ranked 13th worldwide in infant mortality (67.9 deaths/1,000 live births) and 20th worldwide in maternal mortality (489 deaths/100,000 live births). This study’s objective was to determine whether a comprehensive program, incorporating the International Association for Community Development’s recommended holistic elements was effective in a country such as Mozambique.

Method:

Over a 5-year period (2012–2017), an independent, randomized between-group outcome study was conducted to determine whether the holistic Care for Life ( CFL) Family Preservation Program was effective in reducing infant mortality ratios (IMRs) and maternal mortality ratios (MMRs) in Mozambique.

Results:

At preintervention assessment, intervention and comparison villages were statistically equivalent in both IMR and MMR. After 5 years, intervention villages were significantly below the comparison villages in both IMR (odds ratio = 2.3) and MMR (odds ratio = 4.6).

Conclusion:

The use of comparison groups demonstrated the CFL program comprehensive, holistic, and sustainable approach is effective.
Online Higher Education: Faculty Satisfaction and Its Antecedents
Authors: Stickney Lisa T. , Bento Regina F. , Aggarwal Anil , Adlakha Veena
Published: May 2019

The nature and antecedents of faculty satisfaction in online higher education have not received much scholarly attention yet, despite the growing literature that indicates the relevance of faculty satisfaction for outcomes such as the success of e-learning programs, student learning, and student satisfaction. This exploratory study surveyed 171 faculty members from multiple institutions of higher education to learn about their experiences teaching online and to examine factors that might affect their satisfaction. Our study finds that higher education faculty who teach online are generally satisfied, and that satisfaction is more likely if there is appropriate training, and if teaching online allows for flexibility in their schedules. Although a weaker relationship, results also suggest that faculty are more satisfied teaching online when institutional support and organizational policies uphold online teaching efforts. Contrary to our expectations, however, our findings show that faculty who are more satisfied with support for technical elements of the online teaching environment, are less satisfied teaching online. Implications for research and practice are discerned through both the presence and absence of support for three sets of hypotheses, regarding faculty, institutional and technical factors.
Turning Around to Look Ahead: Views of Vocational Psychology in 2001 and 2019
Authors: Fouad Nadya A. , Kozlowski Michael B.
Published: May 2019

Ten scholars in vocational psychology identified strengths, weaknesses, opportunities, and threats in a 2001 issue of the Journal of Vocational Behavior. This article reviews the state of the field in 2001 and then identifies to what extent the strengths and concerns have changed in the past two decades. While the field continues to have a strong theoretical and empirical tradition, old concerns about insularity, methods used to examine research questions, gulfs between science and practice, and turf wars remain a serious threat to the field. We outline the nature of these concerns and propose recommendations from the literature to these concerns.
Lifestyles in Amazon: Evidence from online reviews enhanced recommender system
Authors: Huang Yinghui , Liu Hui , Li Weiqing , Wang Zichao , Hu Xiangen , Wang Weijun
Published: May 2019

Online lifestyles have been shown to reflect and affect consumers’ preferences across a wide range of online scenarios. In the context of e-commerce, it still remains unclear whether online lifestyles are practically influential in predicting consumers’ purchasing preferences across different product categories, especially considering its potential influence over the widely used personality traits. In this study, we provide the first, to the best of our knowledge, quantitative demonstration of online lifestyles in predicting consumers’ online purchasing preferences in e-commerce by using a data-driven approach. We first construct an online lifestyles lexicon including seven distinct dimensions using text mining approaches based on consumers’ language use behaviors. We then incorporate the lexicon in a typical e-commerce recommender system to predict consumers’ purchasing preferences. Experimental results on Amazon Review Dataset show that online lifestyles and all its subdimensions significantly improve preference predicting performance and outperform the widely used Big Five personality traits as a whole. In addition, product types significantly moderate the influence of online lifestyle on consumer preference. The strong empirical evidence indicates that the big e-commerce consumer data facilitates more specialized market psychographic segmentation, which advances data-driven marketing decision-making.
Dishonesty
Authors:   The Baroness Hale of Richmond
Published: May 2019

This article provides an exposition and assessment of the UK Supreme Court judgment in the case of Ivey v Genting Casinos (UK) Ltd. It identifies the Supreme Court’s reconsideration, obiter dictum, of the test of dishonesty in civil and criminal law. This term is used in particular in offences such as those set out in the Theft Act 1968. Prior to the Supreme Court’s intervention, the leading case was R v Ghosh [1982] EWCA Crim 2. However, the Ghosh test in that case has been the subject of significant criticism in the academy and elsewhere, and some such critiques are discussed in the Supreme Court judgment. This article, which considers these developments, was first delivered as the Bristol Alumni Association Lecture on 23 February 2018.
The “Neglected” Relationship Between Child Maltreatment and Oral Health? An International Scoping Review of Research
Authors: Bradbury-Jones Caroline , Isham Louise , Morris Alexander John , Taylor Julie
Published: May 2019

Globally, the oral health needs of children who have, or are suspected of having, experienced abuse or neglect has become a focus of concern. It is thus valuable and timely to map the contemporary nature of the research landscape in this expanding field. This review reports the findings of a scoping review of the international empirical literature. The aim was to explore the relationship between child maltreatment and oral health and how this complex issue is addressed in contemporary dental, health, and social work practice. The review identified 68 papers, analysis of which identified three themes: (1) There is a relationship between poor oral health and child maltreatment that is well evidenced but conceptually underdeveloped. (2) There are discrepancies between the knowledge of members of the dental team about child maltreatment and their confidence and aptitude to identify and report child protection concerns. (3) There are areas of local-level policy and practice development that seek to improve working relationships between dentists and health and social work practitioners; however, there is widespread evidence that the oral health needs of this group of vulnerable children are not consistently met. To orientate critical discussion and planning for future research and practice, we present the Patterns, Advances, Gaps, Evidence for practice and Research recommendations (PAGER) framework. The review’s findings are likely to be of interest to researchers, practitioners, and policy makers working across dentistry, health and social work.
Effect of Wellness Education on Quality of Life of Patients With Non–Small Cell Lung Cancer Treated With First-Line Icotinib and on Their Family Caregivers
Authors: Li Yanwei , Ling Li , Zhanyu Pan
Published: May 2019

Objective: To examine the effects of a wellness-education intervention on quality of life (QOL) of patients with NSCLC treated with icotinib and on their caregivers. Methods: This feasibility study was a prospective pilot randomized controlled trial to evaluate a wellness-education intervention in NSCLC patients and caregivers undergoing icotinib treatment. The participants in the wellness-education group were provided with well-being information over 8 weeks. The Family Environment Scale (FES), Functional Assessment of Cancer Therapy–Lung (FACT-L), Caregiver QOL Index–Cancer Scale (CQOLC), and Hospital Anxiety and Depression Scale (HADS) were measured at baseline prior to randomization and after 8 weeks. Patients completed the FACT-L and HADS, caregivers completed the CQOLC and FES. Results: 67 patients/caregivers in the wellness-education group and 71 in the control group could be analyzed. Feasibility targets were the following: (1) >70% study enrollment of eligible patients; (2) >90% of participants completing this study; (3) <10% missing data. Wellness-education group had better change scores at 8 weeks for the emotional well-being subscale of FACT-L (12.8 vs 15.6, P = .014), anxiety subscale of HADS (6.1 vs 6.7, P = .030), adaptation (66.0 vs 54.7, P = .037) and financial subscales of CQOLC (70.8 vs 69.8, P = .044), and the cohesion (7.3 ± 1.8 vs 5.7 ± 1.7, P= .021) and conflict (3.4 ± 1.9 vs 4.5 ± 1.7, P = .031) subscales of the FES. Conclusion: Wellness-education in patients/caregivers with NSCLC treated with icotinib are feasible and could improve patients’ QOL and their relationship with caregivers.