bluuebunny/crossref_metadata_2025 huggingface dataset:
КОСМИЧЕСКАЯ ЭКОНОМИКА КАК ОТРАСЛЬ ХОЗЯЙСТВОВАНИЯ
Authors: ТУР А. , МЕЛЕШКО Ю.
Published: October 2021

Раскрыты особенности космической экономики как отрасли хозяйствования, в том числе показано, что: космическая деятельность является неотъемлемым элементом нового технологического уклада; формирование комплексной стратегии космической деятельности является частью глубокой структурной модернизации всего политико-экономического механизма страны; космическая деятельность приносит
синергетические экономические эффекты, которые по своим положительным последствиям могут значительно превышать прямую экономическую выгоду; космическая деятельность является сегодня необходимым условием сохранения национального суверенитета. Рассмотрены основные аспекты развития космической отрасли в Республики Беларусь.
ВОЗМОЖНЫЕ СЦЕНАРИИ УПРАВЛЕНИЯ РИСКАМИ ПРОМЫШЛЕННЫХ ПРЕДПРИЯТИЙ
Authors: МАНЦЕРОВА Т. , ТЫМУЛЬ Е.
Published: October 2021

В статье рассмотрены существующие модели управления рисками. Уточнены их преимущества и недостатки. На основе анализа моделей предложен авторский вариант модели управления рисками. Уточнены возможные риски для предприятий энергетики Республики Беларусь при переходе к рынку энергии и мощности
ИННОВАЦИОННЫЙ ПОТЕНЦИАЛ ПРОМЫШЛЕННЫХ ПРЕДПРИЯТИЙ И ЕГО ВЛИЯНИЕ НА КОНКУРЕНТОСПОСОБНОСТЬ
Authors: МУХАТОВ. А.
Published: October 2021

Статья посвящена исследованию проблемам конкурентоспособности промышленных предприятий Республики Беларусь. На наш взгляд, проблема конкурентоспособности промышленности недостаточно исследована. Для того, чтобы проследить взаимосвязь конкурентоспособности промышленности Республики Беларусь и инноваций в промышленность, необходимо оценить уровень конкурентоспособности. Оценка конкурентоспособности проводится с использованием комплексного метода.
ОСОБЕННОСТИ ТРАНСФЕРА ТЕХНОЛОГИЙ В БЕЛОРУССКОЙ ЭКОНОМИКЕ
Authors: ВАСЮЧЕНОК Л.
Published: October 2021

Показано, что в экономике Беларуси присутствуют основные звенья трансфера технологий. Он осуществляется в рамках административной модели «внедрения инноваций» для небольшого числа крупных предприятий. Современным тенденциям общественного развития в большей мере соответствует интерактивная модель трансфера технологий, позволяющая вовлечь в инновационный процесс широкий круг субъектов, создать внутренние стимулы для передачи технологий.
ACCOUNTING OF THE THEORY OF GENERATIONS WHEN PLANNING DEVELOPMENT OF TOURISM INDUSTRY OF BELARUS
Authors: Bunko S.
Published: October 2021

The development of the tourism industry is one of the strategic directions of development of many countries, the contribution of this industry to the world GDP is growing every year. Over the past two decades, the Republic of Belarus has set itself such a task, which is characterized by global trends in the development of this industry. However, despite the significant tourism potential of Belarus, there is a significant lag in the share of the contribution of this sector of the economy to the country's GDP, which continues to remain a negative balance of foreign trade in tourist services of Belarus. In order to improve the use of the existing potential of Belarus in this area, the article discusses the possibility of using the theory of generations in forecasting trends in demand for tourist services.
SOURCES OF THEORETICAL AND METHODOLOGICAL DIFFERENCES IN THE INTERPRETATION OF THE TERMS "FINANCIAL SYSTEM" AND "FINANCIAL STABILITY"
Authors: Luchenok A.
Published: October 2021

The article considers two interpretations of the terms “financial system” and “financial stability”. It is shown that the definition of this concept by the monetarists pursues departmental goals and is focused on the priority of the interests of the banking sector to the detriment of the real sector of the economy and population. It is concluded that it is necessary to bring the activities of the National Bank in line with the Constitution of the Republic of Belarus, as well as the inexpediency of creating the so-called “mega-regulator” in the country.
Grupos de investigación: juntos llegamos lejos
Authors: Quispe-Salcedo Angela
Published: October 2021

En los últimos años, ha sido palpable el esfuerzo para fomentar el desarrollo de la investigación científica en el país, especialmente dentro de las diferentes instituciones de educación superior. Desde el inicio de la reforma universitaria, los lineamientos delimitados por el Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (Concytec) han contribuido al avance vertiginoso de la producción científica de las universidades y otros centros de formación, lo que ha cambiado el paradigma de “universidad que enseña” hacia el de “universidad que investiga”.
Modeling and Analysis of Carbonate Matrix Acidizing Using a New Two-Scale Continuum Model
Authors: Jia Cunqi , Sepehrnoori Kamy , Huang Zhaoqin , Yao Jun
Published: October 2021

Matrix acidizing is a common technique for carbonate reservoir stimulation. In this work, a new two-scale continuum model is developed to study the 2D acidizing process. The Navier-Stokes-Darcy equation is used instead of the Darcy’s-law equation to describe fluid flow. The continuity equation is also modified to consider the mass-exchange term between fluid and solid phases. The comparison results show that neglecting the solid-matrix-dissolution source term results in overestimation of pore volume (PV) to breakthrough (PVBT). The Darcy’s-law equation does not well-capture physical behaviors of fluid phase with low acid-injection velocity compared with the Navier-Stokes-Darcy equation. On the basis of this model, we discuss different processes influencing matrix acidizing, including convection, diffusion, and reaction, and different models, including classical and new two-scale continuum models. Besides, a comprehensive parametric study is also conducted to study the effect of parameters with respect to acid and rock physical parameters on the matrix-acidizing process. The typical dissolution patterns and optimal acid-injection rate presented in experimental studies can be well-observed by the new two-scale continuum model. Increasing the acid-injection concentration has a limited effect on the amount of acid mass but substantially reduces the amount of solute required. The acidizing curve is very sensitive to the dispersity coefficient, acid-surface-reaction rate, and porosity/permeability relationship.
Aqueous Solution of Ketone For Enhanced Water Imbibition in Shale Reservoirs
Authors: Wang Mingyuan , Abeykoon Gayan A. , Argüelles-Vivas Francisco J. , Okuno Ryosuke
Published: October 2021

This paper presents an experimental study of improved oil recovery from fractured shale cores by huff-n-puff of the aqueous solutions of 3-pentanone. The huff-n-puff experiments with different 3-pentanone concentrations were analyzed by the material balance for components: oil, brine, and 3-pentanone. Naturally sulfate-rich brine of low salinity was used as the injection brine.

Results show that the 3-pentanone solution recovered more oil from the shale matrix than the injection brine alone. The oil recovery increased when the 3-pentanone concentration increased from 0.56-wt% to 2.85-wt%. Huff-n-puff with the 2.85-wt% 3-pentanone solution showed the highest improved oil recovery by 3-pentanone. However, the huff-n-puff experiment with the 1.07-wt% 3-pentanone solution showed the highest efficiency measured by the mass ratio of the produced oil to the injected 3-pentanone. That is, an optimal concentration of 3-pentanone appeared to exist. The material balance analysis showed that 3-pentanone was efficiently imbibed into the shale matrix, and that oil was recovered from shale mainly by the displacement by brine after the wettability alteration by 3-pentanone.
Successful Development and Deployment of a Novel Chemical Package for Stimulation of Injection wells, Offshore UK
Authors: Alexis Dennis , Pinnawala Gayani , Kim Do Hoon , Dwarakanath Varadarajan , Hahn Ruth , Solano Marlon , Tao Emily , Winslow Greg , Thach Sophany , Jackson Adam , Wilhelm Aaron , West Scott , Pin Erica , Aujla Sukhjit
Published: October 2021

The work described in this paper details the development of a single stimulation package that was successfully used for treating an offshore horizontal polymer injection well to improve near wellbore injectivity in the Captain field, offshore UK. The practice was to pump these concentrated surfactant streams using multiple pumps from a stimulation vessel which is diluted with the polymer injection stream in the platform to be injected downhole. The operational challenges were maintaining steady injection rates of the different liquid streams which was exacerbated by the viscous nature of the concentrated surfactants that would require pre-dilution using cosolvent or heating the concentrated solutions before pumping to make them flowable. We have developed a single, concentrated liquid blend of surfactant, polymer and cosolvent that was used in near-wellbore remediation. This approach significantly simplifies the chemical remediation process in the field while also ensuring consistent product quality and efficiency. The developed single package is multiphase, multicomponent in nature that can be readily pumped. This blend was formulated based on the previous stimulation experience where concentrated surfactant packages were confirmed to work. Commercial blending of the single package was carried out based on lab scale to yard scale blending and dilution studies. About 420 MT of the blend was manufactured, stored, and transported by rail, road and offshore stimulation vessel to the field location and successfully injected.
Hydrocarbon Field Re-Development in a Bayesian Framework
Authors: Steineder Dominik , Clemens Torsten
Published: October 2021

Hydrocarbon field (re-)development projects are challenging to perform as a number of decisions need to be taken under uncertainty. In addition, data gathering activities need to be performed to decrease the risk of negative outcomes related to project objectives and to select the development option with the highest value.

Many oil and gas E&P companies are using as stage-gate process to mature hydrocarbon field (re-)development projects. Such a process allows for systematic project development including value assurance measures such as peer reviews prior to decision gates. However, the stage-gate leads to challenges if it is not performed in a Bayesian framework. If for example simplified models are used in the early phase of the stage-gate process, no Bayesian updating of believes can be done. Similarly, if the company is not seamlessly integrating project value in project development, the value of development option and of data acquisition cannot be quantitatively determined.

We are showing how to mature projects in a Bayesian framework. We show how data gathering is used to update believes and how generalized sensitivity analysis can be applied to identify which decisions have an impact of project value and which parameters are sensitive to the decision which development option to perform. The key performance indicators such as Expected Monetary Value, Probability of Maturation, Probability of Economic Success are updated. The changes of the sensitivities of the various uncertain parameters with project maturation is monitored and the decision maker is supplied with key performance indicators and residual risks, risk mitigation and management plans at Final Investment Decision.
ANALISIS KESALAHAN MORFOLOGI DALAM MENULIS TEKS DESKRIPSI SISWA KELAS VII MTsN 1 TULUNGAGUNG
Authors: Kaso Subaidah
Published: October 2021

Abstrak

Penelitian ini bertujuan untuk mengidentifikassi kesalahan penggunaan afiksassi dalam penulisan teks deskripsi siswa kelas VII MTsN 1 Tulungagung dan mengidentifikasi penggunaan kata depan dalam penulisan teks deskripsi siswa kelas VII MTsN 1 Tulungagung. Penelitian ini menggunakan metode deskripsi kualitatif. Sumber data berasal dari hasil karya siswa yaitu teks deskripsi. Teknik pengumpulan data penelitian ini menggunakan dokumentasi. Analisis data yang dilakukan dengan membaca secara keseluruhan teks deskripsi yang menjadi objek penelitian, menganalisis kesalahan afiksasi dan kata depan dalam teks deskripsi siswa kelas VII MTs Negeri 1 Tulunagung. Hasil analisis bentuk kesalahan penggunaan afiksasi dan kata depan dalam teks deskripsi siswa bahwa terjadi kesalahan 2 bagian dari afiksasi dan 2 bagian dari kata depan. Penggunaan kesalahan prefiks 19 kesalahan dan penggunaan kesalahan sufiks 4 kesalahan.  Kesalahan penggunaan kata depan “di” 41 kesalahan dan kesalahan kata depan “ke” 3 kesalahan.
ANALISIS KESALAHAN BERBAHASA BIDANG SEMANTIK DALAM PIDATO MENTERI PENDIDIKAN DAN KEBUDAYAAN
Authors: Yana Yuli , Mustofa Hendi , Safitri Lina Dwi
Published: October 2021

In this study, researchers are interested in analyzing language errors in the field of semantics. The subject of this research is the speech of Nadiem Makarim (Minister of Education and Culture). The first speech is about National Teacher's Day 2020, and the second speech is about the commemoration of National Education Day 2021. The method used in this analysis is a qualitative method. The qualitative method shows that the analysis is only based on the facts contained in the speech of the Minister of Education and Culture (Nadiem Makarim). The technique used in this study to collect data is the technique of observing linguistic elements in the speech of the Minister of Education and Culture (Nadiem Makarim) and the technique of systematically recording language errors contained in the speech. In the Mendikbud's speech on the commemoration of National Teacher's Day 2020, there were seven semantic errors, namely in the words chain, laboratory, jump, stakeholder, walking, painter, and the word high. Meanwhile, from Nadiem Makarim's speech, in commemoration of National Education Day 2021, there are also seven semantic errors, namely in sheet words, grasping, breakthroughs, walking in place, leaps, fields, and stretched words. The technique used in this study is a technique for observing linguistic elements in the speech of the Minister of Education and Culture (Nadiem Makarim), and a technique for systematically recording language errors in speeches.
Infinite pseudo-conformal symmetries of classical $T \bar T$, $J \bar T $ and $J T_a$ - deformed CFTs
Authors: Guica Monica , Monten Ruben
Published: October 2021

We show that T\bar{T}, J\bar{T}TT‾,JT‾
and JT_aJTa
- deformed classical CFTs posses an infinite set of symmetries that take
the form of a field-dependent generalization of two-dimensional
conformal transformations. If, in addition, the seed CFTs possess an
affine U(1)U(1)
symmetry, we show that it also survives in the deformed theories, again
in a field-dependent form. These symmetries can be understood as the
infinitely-extended conformal and U(1)U(1)
symmetries of the underlying two-dimensional CFT, seen through the prism
of the ``dynamical coordinates’’ that characterise each of these
deformations. We also compute the Poisson bracket algebra of the
associated conserved charges, using the Hamiltonian formalism. In the
case of the J\bar{T}JT‾
and JT_{a}JTa
deformations, we find two copies of a functional Witt - Kac-Moody
algebra. In the case of the T\bar{T}TT‾
deformation, we show that it is also possible to obtain two commuting
copies of the Witt algebra.
La Red Social Busuu en la Producción Oral en Francés
Authors: Calderín Gutiérrez Adrián
Published: October 2021

Esta investigación tuvo por objetivo implementar una metodología basada en la red especializada en idiomas Busuu para mejorar la producción oral en francés. Se llevó a cabo una investigación de campo, descriptiva con enfoque cuantitativo. Para ello, se creó un curso virtual con una versión gratuita de esta aplicación. La muestra final estuvo conformada por 63 personas de varios países de América Latina, miembros del Club de Francés-Amigos, quienes completaron todas las actividades propuestas en el curso. Los resultados mostraron que el 22% de los participantes obtuvo una calificación de 20/20 en el examen final; el 17% obtuvo calificaciones de 16/20; seguidos por los de 17, con 16%, 18 y 15 con un 13%, respectivamente. Un 5% obtuvo 14 puntos, otro 5%, 10, y el 2%, 13 puntos. Los participantes que utilizaron Busuu entre una y dos o más de dos horas semanales, manifestaron un elevado nivel de satisfacción, y se concluyó que esta metodología resultó ser muy efectiva para ellos; lo que evidencia la eficacia de las redes sociales para potenciar el aprendizaje de nuevas lenguas, sobre todo las competencias orales.
Effect of Capital Structures on Firm Value with Sales Growth and Return on Sales as Control Variables in Consumer Goods Companies Listed on the Indonesia Stock Exchange
Authors: Abidin Zaenal , Putra Rizki Reinaldy , Prabantarikso Mahelan
Published: October 2021

One of the attempts taken by the management to maximize the value of the company to compete with its rivals is decision-making related to capital structure strategy. The research sought to determine the effect of Short-Term Debt (STD) on Total Assets (TA), Long-Term Debt (LTD) to Total Assets (TA), and Total Debt (TD) to Total Assets (TA) on firm value by using return on sales and revenue growth as control variables. The research was correlation research to observe the relationship between one variable and various other variables. The sample was consumer goods companies, especially food and beverage sub-sector manufacturing companies listed on the Indonesia Stock Exchange from 2015 to 2018. With a purposive sampling technique, there were 15 companies out of a total of 27 companies that met the criteria. Data were obtained from the Indonesia Stock Exchange website in the form of financial reports and closing prices. Then, structural equation modeling was used to analyze the data. Based on the analysis, there are several results. First, STD to TA and LTD to TA have a negative and significant impact on firm value. Second, TB to TA has a negative but insignificant impact on firm value. Third, sales growth has a positive and negligible effect. Last, return on sales has a negative and substantial effect.
Dividend Policy as Moderating Variable to the Consumer Goods Company on the Indonesia Stock Exchange
Authors: Toni Nagian , Simorangkir Enda Noviyanti , Goh Thomas Sumarsan
Published: October 2021

The capital market in Indonesia includes many companies from several sectors. One company that cannot be separated from the Indonesian stock market is a consumer goods company. The research aimed to analyze the effect of profitability and capital structure on the company with dividend policy as moderating variable to the consumer goods companies registered on the Indonesia Stock Exchange in the period of 2014-2018. The population in the research was consumer goods companies with subsector of food and drink, cigarette, cosmetic pharmacy, and household goods and appliances. The research applied purposive sampling and obtained 15 companies with 5 years of observation or around 75 samples. Then, the data were analyzed using Smart PLS 3.0. The analysis result shows that profitability, capital structure, and company size positively and significantly influence the company value. However, dividend policy cannot moderate the effect of profitability and capital structure on the company value. The dividend policy can moderate the effect of company size on the company value. Then, profitability, capital structure, and company size influence the company value of 88,6%, while the other factors influence the rest. Investors should decide on issuers with high profitability above 5%, the optimal capital structure with the debt-to-equity ratio between 0,8-1,2, and total assets above five trillion Rupiah.
Effect of Pornography Discourse on the Reception of Novel Stensilan by Enny Arrow
Authors: Anggraini Ariska Puspita , Susanto Dwi , Rais Wakit Abdullah
Published: October 2021

This study aims to analyze the pornography discourse in the reception of Enny Arrow's stencil novels among millennial men. The study is qualitative. The research sample focused on two millennial men in Surakarta who read the novel Enny Arrow stencil intensively. The data collected by interviews and observations over six months. In this study, researchers asked two newly recognized millennial men to read and interpret Enny Arrow's stenciled novel. After that, the researcher looks at the effect on the social relationships of the participants. The theory used to analyze the data in this study was Normand Holland's psychoanalytic literary reception. After the data analysis process, it was revealed that pornography can be both a consumption and a taboo subject. Although it is considered a sensational topic of conversation, the participants considered pornography should not be used as a general topic of conversation.

Keywords: pornography, discourse, sex, stencil novel, Enny Arrow
Social Control of Women’s Body as Cultural-Political Legitimation in “Putri Cina” Novel
Authors: Sartika Resa , Susanto Dwi , Wibowo Prasetyo
Published: October 2021

This research aimed to describe the depiction of the female body’s domination as a form of political-cultural legitimacy raised in Sindhunata’s work entitled Putri Cina. Michel Foucault’s theory of discourse was applied as the approach to reveal how sexuality was closely related to power practices. The discourse presented in the novel was dissected by qualitative methods, descriptive qualitative, and interpretative data analysis techniques. The results show that the two main characters of this novel are Chinese women who experienced oppression in Java. The existence of a cultural identity crisis, abjection, passivity, and not subversion represents the figure of alienated women. This perspective is intertwined with how indigenous men perceive Chinese women figures. Sindhunata describes the unequal construction of sexuality between men and women and the discrimination of the Chinese race as repeated during the kingdom era, pre-independence, to the New Order era.
Social Problem-Solving in Freshmen: The Role of Emotional Stability, Secure Attachment, Communication Skill, and Self-Esteem
Authors: Putri Dona Eka , Rahardjo Wahyu , Qomariyah Nurul , Rini Quroyzhin Kartika , Pranandari Kenes
Published: October 2021

Freshmen during the pandemic faced some complex problems during their transition, including adjustments to the online lecture system and independent learning, task demands, and limited social interaction with lecturers and classmates. This condition required the ability to solve problems effectively and efficiently. The purpose of this research was to determine how emotional stability, secure attachment, communication skills, and self-esteem influence social problem-solving. Participants in this research were 702 first-year students from university X who were active and domiciled in the Jakarta Greater Area and several other cities. The measuring instruments used were the Social Problem-Solving Inventory-Revised Short-Form, the Self-Esteem Scale, the Interpersonal Communication Scale, the Indonesian version of the Big Five Inventory for neuroticism, and the Secure Attachment Scale. The data was collected through an online questionnaire. The data analysis technique used hierarchical regression. The results show that emotional stability in the form of low neuroticism has a strong effect on social problem-solving, and this effect is stronger when the secure attachment variables and communication skills are taken into the analysis. When self-esteem is included as the last variable, secure attachment no longer affects social problem-solving. However, the total influence is simultaneously getting stronger.
From Panic to Confusion to Negotiation: Reflection from Early Response to Covid-19 in Indonesia
Authors: Setiadi Setiadi , Lazuardi Elan
Published: October 2021

This research reflected on the response to the pandemic that emerged as it happened. It drew attention to the viral aspect of a pandemic, namely how people understood and responded to pandemics using various digital platforms. It questioned the context and reasons for what it called an immeasurable but organized community response to the COVID-19 pandemic. Digital-based research was applied through observing three mainstream digital media (Kompas TV, The Jakarta Post, and Detik.com) and social media (i.e., WhatsApp Messenger and Twitter). Data were analyzed thematically by categorizing the ways people responded to COVID-19 via social media into three thematic phases. In the first phase, digital media was used to voice frustration and disappointment with the government’s response. This had sparked public distrust of the government’s ability to deal with the pandemic at the national level. The second phase was the confusion phase. The rise of public discussion about the pandemic showed that the public was concerned about the development of the COVID-19 news in the country. The last phase was the negotiation phase. While COVID-19 was rapidly becoming a source of panic and confusion, grassroots initiatives emerged using social media. These initiatives aimed to help reduce panic and reduce socio-economic impacts. This research shows how anthropologists can still pay attention to social relations forged through social media in times of crisis where traditional anthropological fieldwork is nearly impossible. Methodologically, digital anthropology or social media ethnography is gaining momentum to be developed, considering that fieldwork cannot be done in the pandemic era.
New data on well-known drug: focus on meldonium
Authors: Statsenko M. E. , Turkina S. V. , Lopushkova Yu. E.
Published: October 2021

The article reviews the efficacy of meldonium in patients with various diseases, which are based on secondary mitochondrial dysfunction. Mitochondria are complex cellular organelles that control many metabolic processes, including fatty acid oxidation, the Krebs cycle, oxidative phosphorylation in the electron transport chain, and many other processes. Many conditions can lead to secondary mitochondrial dysfunction and affect other diseases. Damage to mitochondria can promote the activation of free radical processes and the  initiation of  the  mechanisms of  programmed cell death, mitochondrial dysfunction decrease in the immune response, increase in the activity of the body’s inflammatory response in various infections. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as inflammation. The article presents data on the effectiveness of using meldonium as a drug that helps to arrest pathological processes in mitochondria. The main mechanism of action of meldonium is based on a decrease in L-carnitine levels and increase of peroxisomes activity in the cytosol Meldonium was designed as a inhibitor of carnitine biosynthesis aimed to prevent accumulation of cytotoxic intermediate products of fatty acid beta- oxidation in ischemic tissues and to block this highly oxygen- consuming process. It is based on the correction of the energy metabolism of the cell. There was a positive trend in the use of meldonium in patients with diseases of the cardiovascular system (chronic ischemic diseases, chronic heart failure, arterial hypertension, etc.), neurological disorders (stroke, cerebrovascular insufficiency, etc.), respiratory diseases. The data on the beneficial effect of meldonium on the immune response in patients with coronavirus, bronchial asthma, chronic obstructive pulmonary disease, during vaccination with anti-influenza serum are presented. A decrease in asthenia was noted against the background of the use of meldonium in patients who had undergone coronavirus infection.
Drug-induced hypocalcemia
Authors: Listratov A. I. , Ostroumova O. D. , Klepikova M. V. , Aleshkovich E. V.
Published: October 2021

Hypocalcemia (HCa) is one of the main water-electrolyte disturbances in clinical practice. An acute decrease in serum calcium levels can lead to seizures, ventricular arrhythmias, bronchospasm and laryngospasm. Chronic HCa can result in disorientation and confusion. To prevent these complications, the risk factors for low calcium levels must be carefully evaluated. One of these factors is drugs, in which case we are talking about drug-induced (DI) HCa. The list of drugs-inducers of DI HCa is quite extensive, but the leading role in this disorder is played by drugs for the treatment of osteoporosis, antineoplastic and antiepileptic drugs, as well as drugs for anti-tuberculosis therapy. When taking zoledronic acid, DI HCa is observed with a frequency of up to 39%. When taking imatinib, a targeted anticancer drug, a decrease in calcium levels was observed in 40% of cases. The pathophysiological mechanisms of DI HCa can be a decrease in bone resorption, a decrease in the concentration of vitamin D, inhibition of the action of parathyroid hormone and impaired calcium absorption. Risk factors in most cases of DI HCa are vitamin D deficiency and hypomagnesemia. An acute decrease in calcium levels leads to symptoms of neuromuscular excitability, abnormalities on the electrocardiogram (ECG) and electroencephalogram (EEG). The basis for the treatment of DI HCa is the drug withdrawal and the appointment of calcium. It is also necessary to prescribe vitamin D. The main methods of prevention of DI HCa are to determine the level of calcium and vitamin D before starting therapy with culprit medication, and to correct its level. It is also important to prescribe additional amounts of calcium and vitamin D during therapy with such drugs. Awareness of the attending physicians about the problem of DI HCa, a thorough assessment of its risk factors and the prophylactic administration of calcium and vitamin D preparations will help to effectively prevent those serious complications resulting from a decrease in calcium levels in clinical practice.
Hemodynamic effects of combined antihypertensive therapy during exercise in men with arterial hypertension and chronic venous diseases
Authors: Letyagina S. V. , Baev V. M. , Agafonova T. Y.
Published: October 2021

Introduction. Currently, there is insufficient data on the effect of modern antihypertensive therapy (AHT) on venous circulation, especially during physiological stress.Aim of the study – the investigation was to study the hemodynamic effects of a combination of a calcium channel blocker (CCB) and an angiotensin-converting enzyme (ACE) inhibitor during exercise in men with arterial hypertension (AH) and chronic venous diseases (CVD).Material and methods. In 46 men 30–50 years old with AH on the background of AHT, a comparative assessment of the dynamics of SBP, DBP, peripheral venous pressure (PVP), ultrasound parameters of venous blood flow of the left leg in response to physical activity (Ruffier’s test) was performed. The parameters were assessed in 23 patients with hypertension without CVD and 23 patients with hypertension and CVD. We studied the reaction before and after 14 days of combined AHT with the use of CCB (Amlodipine) and an ACE inhibitor (Lisinopril).Results. Before treatment, the response to exercise in patients of both groups was the same and was manifested by a twofold increase in the area of the lumen of the veins and a drop in blood flow velocity. Patients with CVD before treatment with exercise were characterized by an altered systemic hemodynamic response, more frequent cases of venous dilatation and decreased blood flow velocity. After AHT with exercise, both groups showed normalization and identity of SBP. DBP, PVP, a decrease in the severity of venous dilatation and a decrease in blood flow velocity. Patients with CVD after AHT in response to exercise are characterized by more pronounced venous dilatation and higher blood flow velocity.Conclusion. After 14  days of  antihypertensive therapy in  patients with hypertension without chronic venous disease and in patients with hypertension and chronic venous disease during exercise normalization of systolic blood pressure, diastolic blood pressure, PVP, a decrease in venous dilatation and a decrease in blood flow velocity are noted. Patients with CVD after AHT under load are characterized by varicose veins and accelerated venous blood flow.
Systematic errors in the choice of dose level of direct oral anticoagulants: urgency of an issue and approaches to its solution
Authors: Gilyarevskiy S. R. , Bendeliani N. G. , Golshmid M. V. , Kuzmina I. M.
Published: October 2021

The article presents updated information on the frequency of use of non-recommended low dosing of direct oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban). It gives substantiation of the urgency of the issue of providing the maximum efficiency of the use of anticoagulants in clinical practice, taking into account the high prevalence of atrial fibrillation and the pharmacological characteristics of the most commonly used drugs. The effects of such an unreasonable reduction in anticoagulant doses in elderly and senile patients are discussed. The results of recent observational studies that assessed the relationship between the use of direct oral anticoagulants and the risk of adverse clinical outcomes are presented. The data on the relationship between the use of unreasonably low dosing of anticoagulants in patients with atrial fibrillation, which were recently obtained during the implementation of the GARFIELD-AF registry, are discussed. The data on a rather high variability of concentrations of direct oral anticoagulants are presented. The frequency of using apixaban in an unreasonably reduced dose, as well as the effects of using non-recommended doses of apixaban hold a specific place in the article. The unreasonableness of attempts to further reduce the risk of bleeding due to unreasonable reduction of apixaban dosing is emphasized, taking into account the stable data on the high safety of recommended dosing of apixaban, as well as the possible decrease in the effect if the dose reduction is not recommended. The data on the criteria for dose reduction, which are adopted in different countries, are presented. The proposed terms to designate different doses of direct oral anticoagulants, depending on their study in the course of large, randomized trials are discussed.
К анализу факторов риска смертности от злокачественных новообразований мужского населения промышленных моногородов
Authors:   Izmerov Research Institute of Occupational Health, 31 Budennogo Ave., Moscow, 105275, Russian Federation, Tikhonova G.I. , Bryleva M.S. ,   Izmerov Research Institute of Occupational Health, 31 Budennogo Ave., Moscow, 105275, Russian Federation
Published: October 2021

The paper dwells on examining mortality among men due to malignant neoplasms (MNs) in Russia and in Norilsk and Monchegorsk, two monotowns located in the Arctic zone with the only industry there being nickel production. Nickel is a well-known carcinogen. Given rather small population numbers in these two towns, the authors calculated mortality due to MNs that was aver- aged over 8 years (2010–2017) for 5-year age groups and standardized mortality ratios (SMR) for employable and post- employable ages as per this nosology in general and specific MNs localizations as well. Mortality was comparatively analyzed in two male populations in the following pairs: Monchegorsk and Russia, Norilsk and Russia; the analysis was based on data on climatic peculiarities in the towns, working conditions at industrial enterprises, ecological situation, and socioeconomic features including an existing situation in public healthcare. Socioeconomic welfare and public healthcare quality were close to average Russian ones in Monchegorsk, but SMR for employable population was higher than on average in the country: due to MNs in general, by 34.7 %; nickel-specific MNs such as MNs of the lip, mouth, and throat, by 2.2 times; MNs in the stomach, by 1.5 times. In Norilsk working conditions were similar to those in Monchegorsk but the environmental conditions were worse; still, mortality among employable population was lower: due to MNs in general, by 15.4 %; MNs of the lip, mouth, and throat, by 14.0 %; due to MNs in the stomach, by 39.3 %. In comparison with Russia as a whole, mortality due to MNs was also lower at employable age but higher by 21.6 % at post-employable one. A decrease in MNs-related mortality and carcinogenic effects becoming apparent at older ages were achieved due to organizing up-to-date oncologic aid in Norilsk including high-tech diagnostic, treatment, and rehabilitation procedures as well as due to higher living standards in the town.
ASSESSMENT OF THE CONTRIBUTION MADE BY ONCOGENIC FACTORS TO THE RISK OF MALIGNANT NEOPLASMS DEVELOPMENT FOR THE URBAN POPULATION OF WORKING AGE
Authors:   East-Siberian Institute of Medical and Ecological Research, 3, 12a mikrorayon, Angarsk, 665827, Russian Federation, Efimova N.V. , Myl'nikova I.V. ,   East-Siberian Institute of Medical and Ecological Research, 3, 12a mikrorayon, Angarsk, 665827, Russian Federation
Published: October 2021

High morbidity and mortality caused by malignant neoplasms in various age groups among urban population remains a pressing issue that public healthcare has to solve in contemporary megacities. This research concentrated on assessing significance of oncogenic risk factors that could cause malignant neoplasms (MNs) occurrence among urban population aged 18–64 inclusively. 766 people living in an administrative and industrial center in Siberia took part in the research; MNs were diagnosed in 367 out of them (the test group). The research involved calculating individual carcinogenic risks. Oncogenic factors, both environmental and occupational ones, were examined for each patient; attention was also paid to peculiarities of medical and biological characteristics as well as tobacco smoking and alcohol intake. Impacts exerted by the examined factors on risks of MNs occurrence were determined via odds ratios with estimated confidence intervals. First detected MNs frequency amounted to 638.9 ± 41.9 cases per 100 thousand people among women aged 18–64, and 532.6 ± 41.9 cases among men (p > 0.05). The following factors were determined as ones causing elevated risks of MNs occur- rence: carcinogenic hazards at a workplace; hereditary predisposition; tobacco smoking; alcohol abuse; female sex; living under exposure to chemical carcinogens in the environment. Women tended to have certain diseases that are conventionally considered possible risk factors (viral hepatitis B and C and pancreatic diabetes) 1.3 and 2.4 times more frequently than men. All the obtained data can be used for developing a targeted program aimed at malignant neoplasms prevention among urban population and they can also become a vital component in a system for managing risks of malignant neoplasms occur- rence on a given territory.
SOCIETAL DETERMINANTS AS RISK FACTORS OF HIV-INFECTION SPREAD IN REGIONS IN THE RUSSIAN FEDERATION
Authors:   Sociological Institute of the Russian Academy of Sciences, 25/14 7th Krasnoarmeyskaya Str., St. Petersburg, 190005, Russian Federation, Boyarkina S.I. , Khodorenko D.K. ,   Sociological Institute of the Russian Academy of Sciences, 25/14 7th Krasnoarmeyskaya Str., St. Petersburg, 190005, Russian Federation
Published: October 2021

The paper dwells on the results obtained via examining dependence between HIV-infection spread and factors related to social environmental and social structure of population in RF regions. These factors are considered to be potential health risk ones. The authors tested a hypothesis about influence exerted by demographic, economic, cultural and behavioral de- terminants and public healthcare availability on differences in territorial spread of the disease within social-epidemiologic approach. To solve the set task, data that characterized 85 RF regions were taken from official statistical reports. Descriptive statistic analysis was performed and regression models were built up; it allowed testing whether the analyzed factors had their influence in RF regions and selecting the most significant ones to be included into the overall regression model. The research revealed significant contextual differences in HIV-infection spread. Regression analysis showed that 22.0 % differences in a number of HIV-infected people detected in RF regions occurred due to differences in urban popu- lation numbers, provision with ambulatories and polyclinics, and unemployment rate. Moreover, a number of registered crimes committed by minors determined 32.5 % difference in a number of patients with the first diagnosed HIV-infection between the examined regions. These results allow assuming that the greatest influence on spread of the disease in RF regions is exerted by conse- quences of urbanization; this process is usually accompanied with a growth in a share of urban population in a given region, instability on the labor market there as well as related migration processes within the country and wider opportunities to pursue individual behavioral strategies including those that involve law violations and/or are destructive for people’s health.
PELA SEMIÓTICA DO TRIBUNAL DA MÍDIA: UMA LEITURA DO PROGRAMA JORNALÍSTICO “BRASIL URGENTE” SOB A PERSPECTIVA DA CRIMINOLOGIA MIDIÁTICA
Authors: Gardelio Marina Freire Silvão , Alcântara Filipe de Souza
Published: October 2021

O presente trabalho se propõe a interpretar recortes do programajornalístico-policial Brasil Urgente, televisionado pelo canal RedeBandeirantes de Televisão, sob o ponto de vista da criminologiamidiática, denunciada por Eugênio Raul Zaffaroni. A proposta sejustifica no grande alcance que o programa possui no âmbito nacional,e, por tratar de cobertura policial, acabar veiculando opinativos sobrea questão criminal. Desse modo, tentamos elencar, a partir de umaanálise crítica do discurso, quais técnicas utilizadas pelo programa ede que maneira elas se relacionam com as categorias da criminologiamidiática, traçando as principais características do noticiário edialogando com o marco teórico escolhido.
Development of a Nomogram-Based Tool to Predict Neurocognitive Impairment Among HIV-positive Charter Participants
Authors: Naveed Zaeema , Fox Howard S. , Wichman Christopher S. , May Pamela , Arcari Christine M. , Meza Jane , Totusek Steven , Baccaglini Lorena
Published: October 2021

Background:

Despite the widespread use of combination antiretroviral therapy (cART), HIV-associated neurocognitive impairment (NCI) persists in people living with HIV (PLWH). Studies have generated inconsistent results regarding etiological factors for NCI in PLWH. Furthermore, a user-friendly and readily available predictive tool is desirable in clinical practice to screen PLWH for NCI.

Objective:

This study aimed to identify factors associated with NCI using a large and diverse sample of PLWH and build a nomogram based on demographic, clinical, and behavioral variables.

Methods:

We performed Bayesian network analysis using a supervised learning technique with the Markov Blanket (MB) algorithm. Logistic regression was also conducted to obtain the adjusted regression coefficients to construct the nomogram.

Results:

Among 1,307 participants, 21.6% were neurocognitively impaired. During the MB analysis, age provided the highest amount of mutual information (0.0333). Logistic regression also showed that old age (>50 vs. ≤50 years) had the strongest association (OR=2.77, 95% CI=1.99-3.85) with NCI. The highest possible points on the nomogram were 626, translated to a nomogram-predicted probability of NCI to be approximately 0.95. The receiver operating characteristic (ROC) curve's concordance index was 0.75, and the nomogram's calibration plot exhibited an excellent agreement between observed and predicted probabilities.

Conclusion:

The nomogram used variables that can be easily measured in clinical settings and, thus, easy to implement within a clinic or web-interface platform. The nomogram may help clinicians screen for patients with a high probability of having NCI and thus needing a comprehensive neurocognitive assessment for early diagnosis and appropriate management.
Incidence Rate and Time to Occurrence of Renal Impairment and Chronic Kidney Disease among Thai HIV-infected Adults with Tenofovir Disoproxil Fumarate Use
Authors: Visuthranukul Jirayu , Rattananupong Thanapoom , Phansuea Phenphop , Hiransuthikul Narin
Published: October 2021

Background:

Tenofovir disoproxil fumarate (TDF) is a major antiretroviral therapy for Thai human immunodeficiency virus (HIV) infected adults. TDF is associated with a decrease in renal function. There is limited data about the use of TDF with the incidence and time to renal impairment and chronic kidney disease (CKD) in Thai HIV-infected adults.

Objectives:

To study the association of TDF with the incidence rate and duration of renal impairment and CKD in Thai patients.

Methods:

A retrospective cohort study in Thai naïve HIV-infected adults was conducted to compare the incidence rate and time to renal impairment and CKD in TDF and non-TDF groups. The incidence rate was analyzed by person-time. Time to renal impairment and CKD were analyzed by Kaplan-Meier curves and log-rank tests.

Results:

A total of 1,400 patients were enrolled. The incidence rates of renal impairment in TDF and non-TDF groups were 27.66/1,000 and 5.54/1,000 person-years. The rate ratio was 4.99 (95% confidence interval [CI] 2.66–9.35). The incidence rates of CKD in both groups were not significantly different. Themean difference of eGFR between the TDF and non-TDF groups was 1.92 ml/min/1.73 m2 (p = 0.022). Time to onset of renal impairment between the TDF and non-TDF groups was found to differ by approximately 20 months.

Conclusion:

The incidence rate of renal impairment was about five times higher in the TDF group. A rapid decline of eGFR occurred in the first 2–3 years of treatment. Therefore, the renal function of HIV-infected patients should be monitored so that the severity of renal impairment could be evaluated and CKD could be prevented.
PENGGUNAAN MEDIA PEMBELAJARAN BERBASIS ANDROID PADA PEMBELAJARAN TEKS EKSPOSISI
Authors: Riyan Muhamad
Published: October 2021

Learning media is important for the continuity of learning activities so that these activities jave variations that make students not bored. One of them is with android-based learing media. The android-based learning media is form of alignment in the field of education with advances in the field of technologu. This study aims to produce android-based learning media as a form of learning variation in exposition texts. In addition, this study also aims to see student responses to android-based learning applications. This research method uses a qualitative descriptive method with interview techniques. The object of this research is an application that is organized according to the subject matter and also a review of this android-based learning application. The results of this study indicate that this android-based learning media application has good feasibility to be used as a variation of new learning media in Indonesian lessons.Keywords: Media, learning, android, text, exposition
EVALUASI PERSPEKTIF POLITIK TRUMP PADA “SAVE AMERICA RALLY”
Authors: Wijaya Ikha Adhi , Annas Annas , Sumarlam Sumarlam
Published: October 2021

(Title: The Evaluation of Trump’s Political Perspectives at The  “Save America Rally”). This paper explores Trump speech in online media CBC news entitled “Live Coverage: Protesters Swarm Capitol, Abruptly Halting Electoral Vote Count” in the point of view of discourse analysis. This research belongs to qualitative research. The method used to analyze is distributional and referential method. It analyzed Trump ideology’s Perspectives through structure manifested by Emotive words, phrases, sentences from his speech, specifically it explored from critical discourse analysis conducted by Teun A .Van Dijk.  It resulted and indicated that Trump conveyed his political will by protesting the result of the ballots. He said there was fraud in the middle of the election. In fact, instead of protesting the election, he also conveyed the autocritics towards the government (himself). Key Words:  speech, Trumps, critical discourse analysis, ideology