bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and In vitro, Ex vivo Evaluation of Benzidamine Hydrochloride
Loaded Fast Dissolving Oral Strip Formulations: Treatment of Oral
Mucositis Due to Side Effects of Chemotherapy and Radiotherapy
Authors: Yenilmez Evrim , Öztürk Ahmet Alper , Başaran Ebru
Published: February 2023

Background:

Rapidly dissolving oral strips have many advantages, especially in pediatric and
geriatric use. Benzydamine hydrochloride is an active substance with local analgesic, anesthetic, antimicrobial
and non-steroidal anti-inflammatory properties.

Objective:

The aim of the study was to formulate and characterize orally dispersible benzydamine hydrochloride-
loaded fast dissolving oral strips for the sufficient treatment of oral mucositis with high loading
capacity as well as high patient compliance considering ease of use.

Methods:

Oral strips were prepared by solvent casting method with many different polymer combinations
and evaluated for different characteristics. In vitro and ex vivo characterizations were performed.

Results:

In appearance oral strips were smooth and they were also uniform in thickness and weight. The
release rates of the active agent from oral strips reached 100% within 25 minutes. The disintegration time
was within the range of 15.5 ± 1.2 seconds. Due to ex vivo permeation studies steady-state flux of benzydamine
hydrochloride in simulated saliva and pH 6.8 were found to be 27.1 μg cm−2 h−1 ± 1.4 and 26.2 μg
cm−2 h−1 ± 1.7, respectively. No significant difference (p˃0.05) in permeability studies was observed using
pH 6.8 phosphate buffer compared to simulated saliva.

Conclusion:

Active agent was successfully loaded into the strips and the targeted system was successfully
performed. Benzydamine hydrochloride as oral strips can be a better solution for the efficient treatment of
oral mucositis for cancer patients during chemotherapy and radiotherapy stages.
Standardised ido-BR1 Cucumber Extract Improved Parameters Linked to
Moderate Osteoarthritis in a Placebo-controlled Study
Authors: Nash Robert James , Mafongang Amelie , Singh Harinder , Singwe-Ngandeu Madeleine , Penkova Yana Boycheva , Kaur Taranjeet , Akbar Junai
Published: February 2023

Background:

According to the World Health Organization, osteoarthritis (OA) is one of the 10 most disabling diseases in developed countries, with worldwide estimates of 9.6% prevalence in men and 18.0% in women over 60 years old. Its management is not well established and involves the use of high doses of painkillers coupled with anti-inflammatory agents.

Objective:

In the search for alternatives to manage the disease, previous studies have shown superi-or properties of Q-ActinTM in managing OA-related pain compared with standard treatments. Q-actin is a cucumber extract with the anti-inflammatory iminosugar idoBR1 standardised to over 1%. This study investigated the effects of different doses (20 mg, 100 mg) of Q-Actin in a longitudinal placebo-controlled experiment.

Methods:

There were 101 patients with knee OA enrolled for the 180-day study, with 91 patients completing it. Patients were grouped into a placebo group (PLBO), as well as a 20mg dose (Q-Actin 1) and 100 mg dose (Q-Actin 2) groups. The PLBO group received cellulose in capsules identical to the Q-Actin capsules.

Results:

There was a significant improvement in the pain-related parameters over time that was dose-dependent.

Conclusion:

This study clearly demonstrated the effectiveness of Q-Actin compared to placebo in the management of pain related to moderate osteoarthritis.
A Friendly Strategy for an Organic Life by Considering Syrian Bean
Caper (Zygophyllum fabago L.), and Parsnip (Pastinaca sativa L.)
Authors: Shahrajabian Mohamad Hesam , Sun Wenli
Published: February 2023

Background:

Medicinal plants have become the focus of intense researches through
the identification and determination of their pharmacological benefits with their different chemical
constituents.

Objective:

The aim of this mini-review is to highlight the most important health benefits of Syrian
bean caper and parsnip.

Methods:

The manuscript consists of review articles, randomized control experiments, and analytical
studies, which have been gathered from different sources such as Scopus, Google Scholar,
Science Direct, and PubMed. A review of the literature was carried out using keywords such as
health benefits, pharmaceutical properties, Syrian bean caper (Zygophyllum fabago L.), and
Parsnip (Pastinaca sativa L.).

Results:

Syrian bean caper is good for diabetes, lower cholesterol, is appropriate for people aiming
for weight loss, is a good source of vitamin K for healthy bones, protects skin from harmful
ultraviolet rays, prevents cancer and skin ailments, protects from allergies, helps in digestion, increases
immunity, treats anemia, moistens skin, helps in relieving congestion. Syrian bean caper
is also anexcellent source of minerals such as calcium, copper, iron, and sodium which gives
stronger teeth, is a source of anti-ageing, good for the eyes, and reduces skin disorders, it consists
of a good amount of iron and vitamin B which makes it a good candidate to have healthy hair,
and relieves constipation. Parsnips are a type of root vegetable, closely related to parsley roots
and carrots. Parsnips are an excellent source of various nutrients, minerals, and vitamins such as
folate, vitamins C and K, they are rich in antioxidants, a great source of soluble and insoluble fiber,
a great source of a healthy weight loss diet, and support immune function.

Conclusion:

According to phytochemical advantages and pharmacological benefits, Syrian bean
caper (Zygophyllum fabago L.) and Parsnip (Pastinaca sativa) show their importance as medicinal
plants in both traditional and modern medicine.
Computational Techniques for Drug Repurposing: A Paradigm Shift in
Drug Discovery
Authors: Rao Monica Raghavendra Prasad , Ghadge Isha Sangram , Kulkarni Saurav Prasanna , Asthana Tanya
Published: February 2023

The last two years from 2020 to 2022 have seen the world face an unparalleled crisis in the
form of the corona virus, which has challenged mankind as never before. The struggle and race to find
a cure for the disease kept medical professionals, pharmacists, and scientists on their toes. Drug discovery
by de novo approach was not an option due to its obvious downside of the enormous time required
for the process. Hitherto unknown in public parlance, repurposing existing drugs showed the
way forward for scientists. Drug repurposing involves redefining medical use for drugs that have
crossed the drug discovery process and were approved, discontinued, or shelved. Drug repurposing or
repositioning has shown effective results in treating several diseases. This review traces the journey of
some repurposed drugs and provides an overview of computational methods used for repurposing,
which include signature mapping, molecular docking, and in silico approaches. The review also highlights
repurposed drugs for cancer, one of the most dreaded diseases, and how repurposing can prove
to be a boon for many types of cancers. Concerted efforts to study this modality of drug discovery are
the need of the hour. The article discusses various drugs which have been successfully repurposed for
the treatment of a plethora of diseases. Drug repurposing is a silver lining that can reduce the arduous
journey of discovering a definitive cure for a disease and has the potential to change the landscape of
the drug discovery process.
COVID-19: Impact, Diagnosis, Management and Phytoremediation
Authors: Ata Athar , Naz Samina , Sandhu Simran , Sener Bilge
Published: February 2023

COVID-19, or SARS-CoV-2, is an extremely deadly virus that is responsible for over
half a million deaths of people in the world. This virus originated in China in December 2019 and
rapidly spread worldwide in 2-3 months, and affected every part of the world. Its life-threatening
nature forced governments in all countries to take emergency steps of lockdown that affected the
entire world's education, health, social and economic aspects. Due to the implementation of these
emergencies, the population is facing psychological, social and financial problems. Additionally,
this pandemic has significantly influenced the health care systems as all the resources from governments
of all countries were directed to invest funds to discover new diagnostic tests and manage
COVID-19 infection. The impact of the COVID-19 pandemic on the education and social life of the
population is described in this article. Additionally, the diagnosis, management, and phytoremediation
to control the spread of COVID-19 and traditional medicinal plants' role in managing its mild
symptoms have been discussed.
Análisis de las publicaciones científicas sobre educación inclusiva en Colombia
Authors: Arteta Martha Lucía
Published: February 2023

Objetivo: analizar el devenir evolutivo de las publicaciones científicas sobre el tema de la educación inclusiva en Colombia. Método: cuantitativo, descriptivo de tipo bibliométrico bajo el método PRISMA; se recurrió a un periodo de indagación de 10 años (2011-2021) haciendo uso de la base de datos de acceso abierto REDIB, utilizando una ecuación de búsqueda con sus respectivos booleanos. El análisis arrojó una totalidad de 42 publicaciones luego del filtrado. Resultados: No hay homogeneidad en las investigaciones sobre educación inclusiva y esto impide la consolidación de los procesos. Asimismo, la mayoría de los artículos reflejan indagaciones descriptivas lo cual indica que no hay intervención y/o transformación. Conclusiones: Finalmente, el tema se concentra en la inclusión por diversas discapacidades, pero poco se toca el tema de la diversidad étnica, racial, económica entre otras y que forman parte de la sociodiversidad de Colombia.
Contexto de cadena plantas aromáticas
Authors: Castillo Galindo Nicolle Tatiana
Published: February 2023

En esta ficha de contexto se mencionan los aspectos importantes de la cadena de plantas aromáticas enfocados a su marco productivo, regional, económico, comercio internacional, así como sus perspectivas y tendencias frente al mercado, dando a conocer su entorno de Ciencia y Tecnología e Innovación.
Componente animal: recurso animal
Authors: Paternina Diaz Enoc , Cañas Álvarez Jhon Jacobo
Published: February 2023

Aquí se relacionan las razas o grupos genéticos predominantes en el sistema productivo de carne ovina del trópico bajo.
A Bespoke Electronic Health Journal for Monitoring Response to Botulinum Toxin in Treatment of Cervical Dystonia: Open-Label Observational Study of User Experience (Preprint)
Authors: Edwards Colin , Borton Rebecca , Ross Anita , Molloy Fiona
Published: February 2023

BACKGROUND

The mainstay of treatment for cervical dystonia (CD) is regular botulinum toxin injections every 3-4 months. Clinical evaluation of response is dependent on the patient’s recall of how well symptoms responded to the previous injection. A mobile health app could assist both patients and health care professionals to monitor treatment benefits and side effects to assist with the selection of muscle and toxin dose to be injected at the next visit. The DystoniaDiary is a bespoke electronic health journal for monitoring symptoms of CD and response to treatment.

OBJECTIVE

The objective of this study was to assess the acceptability and utility of the DystoniaDiary in patients with CD treated with botulinum toxins as part of their usual care.

METHODS

In this open-label, single-center, single-arm observational study, patients attending a botulinum toxin injection clinic were invited to download the DystoniaDiary app. Patients selected up to 3 of their most troublesome CD symptoms (from a predefined list) and were prompted every 3 days to rate the control of these symptoms on a scale from 0 (very badly) to 100 (very well). Dates of onset and wearing off of response to injected botulinum toxin and responses to the Cervical Dystonia Impact Profile (CDIP-58) questionnaire at baseline and week 6 were also recorded in the app.

RESULTS

A total of 34 patients installed DystoniaDiary. Twenty-five patients (25/34, 74%) recorded data for ≥12 weeks and 21 patients (21/34, 62%) for ≥16 weeks. Median time between the first and last data input was 140 days with a median of 13 recordings per patient. User experience questionnaires at weeks 4 and 12 (20 respondents) indicated that the majority of respondents found the DystoniaDiary app easy to install and use, liked using it, would recommend it to others (19/20), and wished to continue using it (16/20). A smaller proportion indicated that the DystoniaDiary gave a greater sense of control in managing their CD (13/20). There was interindividual variation in patients’ perceptions of control of their symptoms after botulinum toxin injection. Response to treatment was apparent in the symptom control scores for some patients, whereas the severity of other patients’ symptoms did not appear to change after treatment.

CONCLUSIONS

This observational study demonstrated that the DystoniaDiary app was perceived as useful and acceptable for a large proportion of this sample of patients with CD attending a botulinum toxin clinic. Patients with CD appear to be willing to regularly record symptom severity for at least the duration of a botulinum injection treatment cycle (12-16 weeks). This app may be useful in monitoring and optimizing individual patient responses to botulinum toxin injection.
Uptake of Remote Physiologic Monitoring in the US Medicare Program: A Serial Cross-sectional Analysis (Preprint)
Authors: Curtis Jeffrey R , Willig James
Published: February 2023

UNSTRUCTURED

—
Moving Forward With Telehealth in Cancer Rehabilitation: Patient Perspectives From a Mixed Methods Study (Preprint)
Authors: O'Neill Linda , Brennan Louise , Sheill Grainne , Connolly Deirdre , Guinan Emer , Hussey Juliette
Published: February 2023

BACKGROUND

The COVID-19 pandemic accelerated the use of telehealth in cancer care and highlighted the potential of telehealth as a means of delivering the much-needed rehabilitation services for patients living with the side effects of cancer and its treatments.

OBJECTIVE

This mixed methods study aims to explore patients’ experiences of telehealth and their preferences regarding the use of telehealth for cancer rehabilitation to inform service development.

METHODS

The study was completed in 2 phases from October 2020 to November 2021. In phase 1, an anonymous survey (web- and paper-based) exploring the need, benefits, barriers, facilitators, and preferences for telehealth cancer rehabilitation was distributed to survivors of cancer in Ireland. In phase 2, survivors of cancer were invited to participate in semistructured interviews exploring their experiences of telehealth and its role in cancer rehabilitation. Interviews were conducted via telephone or video call following an interview guide informed by the results of the survey and transcribed verbatim, and reflexive thematic analysis was performed using a qualitative descriptive approach.

RESULTS

A total of 48 valid responses were received. The respondents were at a median of 26 (range 3-256) months after diagnosis, and 23 (48%) of the 48 participants had completed treatment. Of the 48 respondents, 31 (65%) reported using telehealth since the start of the pandemic, 15 (31%) reported having experience with web-based cancer rehabilitation, and 43 (90%) reported a willingness for web-based cancer rehabilitation. A total of 26 (54%) of the 48 respondents reported that their views on telehealth had changed positively since the start of the pandemic. Semistructured interviews were held with 18 survivors of cancer. The mean age of the participants was 58.9 (SD 8.24) years, 56% (10/18) of the participants were female, and 44% (8/18) of the participants were male. Reflexive thematic analysis identified 5 key themes: telehealth improves accessibility to cancer rehabilitation for some but is a barrier for others, lived experiences of the benefits of telehealth in survivorship, the value of in-person health care, telehealth in cancer care and COVID-19 (from novelty to normality), and the future of telehealth in cancer rehabilitation.

CONCLUSIONS

Telehealth is broadly welcomed as a mode of cancer rehabilitation for patients living with and beyond cancer in Ireland. However, issues regarding accessibility and the importance of in-person care must be acknowledged. Factors of convenience, time savings, and cost savings indicate that telehealth interventions are a desirable patient-centered method of delivering care when performed in suitable clinical contexts and with appropriate populations.
Expanding Protection and Value Promotion of Cultural Routes to Promote Rural Revitalization—A Case Study of Ya’ an Section of the Sichuan-Tibet Ancient Tea-Horse Road
Authors: Liu Tao , Song Pengyun
Published: February 2023

As a new theory of cultural heritage protection and research, cultural routes emphasize the integrity of culture and pay more attention to the interaction and integration between cultural communities along the route. The Ancient Tea-Horse Road is an important cultural, economic and religious exchange link between the various ethnic groups in the Han and Tibetan two places. As the starting point of the line, Ya ‘an section plays an extremely important role in history. Under the concept and connotation of cultural routes, this paper explores the cultural value of the Ya’an section of the Sichuan-Tibet Tea Horse Ancient Road with the idea of cultural integrity along the line, integrates the cultural elements along the line to form an integrated cultural industry cluster along the line, establishes the tea-horse ancient road cultural route heritage system and the management system of overall coordination and overall protection, deeply excavates the multiple values of the cultural industry along the line, promotes the coordinated development of the line, and empowers the rural revitalization along the line.
Mapudungun, Interculturality and Inclusiveness in the Chilean Educational System
Authors: Salum Tomé, PhD José Manuel
Published: February 2023

Mapudungun is one of the heritages that defines the identity of the Mapuche people. Their survival over time is mainly due to the re-ethnification processes that have occurred in the last decade. However, it is necessary to follow the strategies briefly developed in this work, in order to maintain its validity and revitalization in the Chilean sociocultural context. A maintenance program for this indigenous language must have the proper state support to become a healthy and self-sufficient language. All this will allow the continuation of the way of life of its users, as well as the faithful reflection of their culture within the multicultural world.
Trabajo de campo en Nuevo Durango, Quintana Roo
Authors: Arroyo Vallín Andrés
Published: February 2023

Esta pequeña colección de imágenes tiene como objetivo narrar de forma cronológica algunos de los procesos que nos tocó vivir en la comunidad [Nuevo Durango, Quintana Roo] en torno a la festividad de la Virgen y cómo nos involucramos en ellos. El registro fotográfico y videográfico se realizó mientras se establecían algunas charlas y eran grabadas algunas entrevistas que explicaban los procesos y el significado de cada uno de los pasos rituales.
Berenice Granados Vázquez. Emiliano Zapata. Vida y virtudes según cuentan en Morelos.
Authors: Arranz Mínguez Conrado J.
Published: February 2023

"La historia oficial tiene sus cauces para convertir a los seres humanos en héroes, símbolos, mitos o leyendas. Su desmitificación, si acaso, puede producirse recurriendo a la memoria, ya sea que esté consignada en un archivo o en la palabra oral transmitida por las personas que forman parte de los espacios de significación. Como sabemos, no todas han podido ser eslabones de la cadena que constituye un acervo, pero sí receptores y transmisores de las redes que animan la palabra y que se acercan al fuego para dar luz a la historia, por usar la metáfora de Agamben en El fuego y el relato (2016)..."
Un nuevo ciclo y transformación en la Revista CuidArte
Authors: Reyes García Vianey
Published: February 2023

Resumen
HIPOTERMIA TERAPÉUTICA: PARA LA MEJORA DE LA SUPERVIVENCIA Y ESTADO NEUROLÓGICO EN PACIENTES POS PARO CARDIACO
Authors: Peraza Noh Lorenza Antonia , Rosado Alcocer Ligia María , Montañez Paul Enif Isaias
Published: February 2023

Introducción. El paro cardiaco es una entidad repentina que desencadena la muerte del paciente o en su defecto consecuencias funcionales a nivel neurológico de forma irreversible. La hipotermia terapéutica es una intervención que ha sido estudiada a lo largo de los años como adyuvante del manejo del síndrome posparo para favorecer y preservar el estado neurológico. Objetivo. El presente artículo tiene como objetivo recabar evidencia sobre la intervención hipotermia terapéutica para la mejora de la supervivencia y preservación neurológica en pacientes posparo. Metodología. Revisión sistemática, a través del lenguaje documental del DeCS y MeSH, consultando las bases de datos: PUBMED, Epistemonikos, COCHRANE, ELSEVIER, Google Académico; el estudio está basado en la guía PRISMA.  Discusión. El manejo de la temperatura es una práctica sugerida como intervención en el síndrome posparo un reciente ensayo clínico apoya que la hipotermia terapéutica tiene efectos similares a la no aplicación de la misma y enfatiza el manejo de la temperatura normal. Conclusión. De acuerdo a la revisión sistemática de alcance de la literatura no se evidencia una respuesta contundente que demuestre que la hipotermia terapéutica mejore la supervivencia y estado neurológico de manera ideal y que es suficiente el control de la temperatura entre 36-37°C para evitar los efectos relacionados con la respuesta inflamatoria resultado del paro cardiaco.
EL CAMINO DE LA INVESTIGACIÓN EN ENFERMERÍA
Authors: Jiménez Gutiérrez Marcio
Published: February 2023

Siendo una profesión aún joven, la enfermería se ha desarrollado hasta alcanzar un estatus disciplinar. Ha adquirido un cuerpo de conocimientos que le permite prever, actuar y evaluar en beneficio de quienes requieren de atención en salud en un campo delimitado de la asistencia sanitaria: el cuidado humano en el proceso salud enfermedad. [...]
Uniaxial cyclic stretch enhances osteogenic differentiation of OPLL-derived primary cells via YAP-Wnt/β-catenin axis
Authors:   Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology, Orthopaedic Research Institute/Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Zhu Z , Tang T , He H , Wang F , Chen H , Chen G , Zhou J , Liu S , Wang J , Tian W , Chen D , Wu X , Liu X , Zhou Z , Liu S
Published: February 2023

The pathogenesis of posterior longitudinal ligament ossification (OPLL) remains inadequately understood. Mechanical stimulation is one of the important pathogenic factors in OPLL. As one of the mechanical stimulation transduction signals, the yes-associated protein (YAP) interacts with the Wnt/β-catenin signalling pathway, which plays an important role in osteogenic differentiation. This study aimed to demonstrate the role of YAP-Wnt/β-catenin axis in cell differentiation induced by mechanical stress. Primary cells extracted from posterior longitudinal ligament tissues from OPLL or non-OPLL patients were subjected to sinusoidal uniaxial cyclic stretch (5 %, 0.5 Hz, 3 d). The expression of runt-related transcription factor 2, collagen I, osterix, osteocalcin and alkaline phosphatase were compared between the static and the experimental groups. In addition, the cytoskeleton was detected using phalloidin staining while YAP phosphorylation states and nuclear location were identified using immunofluorescence. The results showed that mechanical stretching loading increased the expression of osteogenic genes and proteins in the OPLL group, while it had no significant effect on the control group. When OPLL cells were stretched, YAP exhibited an obvious nuclear translocation and the Wnt/β-catenin pathway was activated. Knocking down YAP or β-catenin could weaken the impact upon osteogenic differentiation induced by mechanical stimulation. YAP-mediated mechanical stimulation promoted osteogenic differentiation of OPLL cells through Wnt/β-catenin pathway and this progress was independent of the Hippo pathway.
Nanotechnology
Authors: Dukhande Govind , Bharati Ashwini , Tasgaonkar Rupali
Published: February 2023

Abstract: Nanotechnology is the exploitation of the unique properties of materials at the nanoscale. Nanotechnology has gained popularity in several industries, as it offers better-built and smarter products. The application of nanotechnology in medicine and healthcare is referred to as nanomedicine, and it has been used to combat some of the most common diseases, including cardiovascular diseases and cancer. The present review provides an overview of the recent advances of nanotechnology in the aspects of imaging and drug delivery.
Design and Fabrication of Pneumatic Air Vehicle
Authors: S Velmurugan , K Gowtham , B Divesh , Kumar S Pradeep
Published: February 2023

Abstract: This paper work deals with the Compressed- air vehicle as a pneumatic actuator that converts one form of energy into another. The Air Driven Vehicle is an eco-friendly vehicle which operates with compressed air. This Vehicle uses the expansion of compressed air to drive the pistons of the vehicle. An Air Driven Vehicle is a pneumatic actuator that creates useful work by expanding compressed air. There is no mixing of fuel with air as there is no combustion. An Air Driven Vehicle makes use of Compressed Air Technology for its operation The Compressed Air Technology is quite simple. If we compress normal air into a cylinder the air would hold some energy within it. This energy can be utilized for useful purposes. When this compressed air expands, the energy is released to do work. So this energy in compressed air can also be utilized to displace a piston. Compressed air propulsion may also be incorporated in hybrid systems, e.g., battery electric propulsion and fuel tanks to recharge the batteries. This kind of system is called hybrid-pneumatic electric propulsion. Additionally, regenerative braking can also be used in conjunction with this system
A Survey Paper on Sign Language Recognition System using OpenCV and Convolutional Neural Network
Authors: Tambuskar Himanshu , Khopde Gaurav , Ghode Snehal , Deogirkar Sushrut , Vaidya Er. Manisha
Published: February 2023

Abstract: Communication is a very important part of our Human life to express feelings and thoughts. People like the Deaf & Dumb always face difficulty as they cannot speak in their regional languages. Language performs a very important role in communication, it can be verbal i.e. using words to speak, read and write or non-verbal using facial expressions and sign language. So, people like the Deaf and Dumb have the only choice to speak in Sign language means non-verbal. However, Sign language is a very important mode of their community. But it is difficult for people who are unaware of sign language. Hence, here is a system “Sign Language Recognition System Using Open CV and Convolutional Neural Network”. We proposed a system that converts sign language to their appropriate alphabet, words in a standard language to make easily understood by all. We also make some default gestures that we daily use in our day-to-day life. The project works on a learning algorithm, it requires the collection of datasets which includes images of each alphabet, and digits to train the model. For the classification of the image convolutional neural network is used. Also for accessing the camera and taking input we used an open cv.
A POLÍTICA DE RECURSOS HÍDRICOS NO CONTEXTO DA INSTITUCIONALIZAÇÃO DO COMITÊ DA BACIA HIDROGRÁFICA DO RIO MARAPANIM NO PARÁ
Authors: Silva Junior Monaldo Begot da , Simões Aquiles Vasconcelos , Mendes Ronaldo Lopes Rodrigues , Farias Monique Helen Cravo Soares
Published: February 2023

A Bacia Hidrográfica do Rio Marapanim está inserida na Unidade Hidrográfica da Costa Atlântica–Nordeste, no estado do Pará, a qual é a mais densamente povoada e desenvolvida economicamente. A fim de gerir o uso de recursos hídricos, visando a sua disponibilidade, em qualidade e quantidade, para as atividades humanas, foi instituído o Comitê dessa bacia, em 2019. O objetivo desse artigo é analisar os desafios e as oportunidades da institucionalização do Comitê da Bacia Hidrográfica do Rio Marapanim (CBHRM), a partir das ideias intrínsecas à política de recursos hídricos, com foco na gestão compartilhada e participativa. Emprega-se o suporte teórico-metodológico da abordagem cognitiva da análise de políticas públicas. Adota-se o modelo de interpretação pelo referencial da política de Muller (2011). Analisa-se a natureza dos referenciais setoriais e globais que dão sentido à gestão da água e como esses referenciais são interpretados pelo poder público, usuários e comunidades locais. O modelo de análise do artigo segue o método hipotético-dedutivo. O estudo é qualitativo, analítico e exploratório e inicia-se com uma pesquisa bibliográfica e documental, em seguida abordar-se a construção do CBHRM, para somente então analisar a política de recursos hídricos. Supõe-se que as ideias que dão sentido à essa política são dominadas por valores macroeconômicos neoliberais e desenvolvimentistas, inclusive, a política do Pará. Apesar disso, conclui-se que o CBHRM pode se estabelecer como um território para a governança da água, desde que supere os desafios globais impostos ao local e represente a oportunidade de consolidar a descentralização e a participação.
Análisis de sentimientos en twitter sobre aprendizaje móvil
Authors: Gil Ramírez Hernán , Guilleumas García Rosa María
Published: February 2023

El aprendizaje móvil (m-learning) genera reacciones encontradas entre expertos en educación y organismos orientadores y reguladores de esta. Espacios como Twitter son escenario de discusiones y propuestas sobre m-learning, lo que requiere identificar las tendencias de los temas de interés, la polaridad y los usuarios potencialmente más influyentes en estas publicaciones. A partir de la revisión sistemática de literatura realizada en Scopus y Web of Science se identificaron 21 documentos sobre análisis de sentimiento en Twitter, de los cuales solo el 10% trataba sobre m-learning. Un proceso de monitorización pudo permitir la identificación de tendencias en los temas de interés, la polaridad y los usuarios potencialmente más influyentes en las publicaciones sobre m-learning en Twitter. Usando la API Rest de Twitter se importaron 27.668 tuits entre el 28/09/2019 y el 28/12/2019. Se procesaron mediante análisis de redes sociales, minería de texto y análisis de sentimientos, usando NodeXL y el Lenguaje R. La red de comunicación creada mostró 20.530 nodos, 36.240 conexiones y 4.974 grupos. El 49% de los tuits expresaba sentimiento positivo, el 10% negativo, y el 41% neutro. Las tendencias en los temas de interés se asociaron a hashtags como #edtech, #education, #AI. Usuarios como @eraser, @favfuckboi y @kurteichenwald se destacaron entre los potencialmente más influyentes dentro del conjunto de quienes publicaron tuits identificados como positivos y @zaiddibis, @sian_ruffell, @zimperium dentro del grupo de los negativos. La investigación busca avanzar en la comprensión de las opiniones sobre el desarrollo de propuestas educativas apoyadas en dispositivos móviles. Los avances metodológicos y los procesos de análisis desarrollados podrán ser usados en campos como la salud, la política y los desastres naturales.
The Nanling Mountains of southcentral China played a variable role as a barrier and refuge for birds depending upon landscape structure and timing of events
Authors: Wang Zhengzhen , Zhang Min , Zhao Xuebing , Xie Jiami , Peng Yougui , Sheldon F. H. , Zou Fasheng
Published: February 2023

The Nanling Mountains are an important mountain range and watershed in
southcentral China. Because of the abundance in relictual plant species
and geological stability throughout the Cenozoic, the mountains are
considered a “museum” of subtropical biological diversity. With
respect to birds, however, the roles of the Nanling Mountains in
impeding the dispersal of the subtropical birds and, as a result,
shaping their population and community structures have received little
consideration. To examine these roles, we compiled and analyzed two
datasets. (1) To test the mountains’ influence on gene flow, we
undertook a population phylogeographic study comparing mitochondrial COI
and Cytb DNA sequences of 5 sylvioid resident bird species of the
mountains (Huet’s Fulvetta Alcippe hueti, Red-billed Leiothrix Leiothrix
lutea, Greater Necklaced Laughingthrush Pterorhinus pectoralis,
Indochinese Yuhina Staphida torqueola, and Mountain Bulbul Ixos
mcclellandii). (2) To examine differentiated community development over
the history of modern birds, we examined distributional data of all
species of the Nanling region using public species occurrence records.
For part (1), we sampled 327 individuals from 36 sites and conducted
correlation analysis of genetic and geographic distances, taking into
account the landscape of the mountains. We found that the mountains do
not seriously impede gene flow among populations but influenced species
differently. For part (2), comparative analysis of 446 species in 81
families indicated that family membership influenced the community
composition of birds in Nanling region. Variation in family
distributions is attributable to both environmental and evolutionary
factors. Overall, we found that the Nanling Mountains are not currently
a substantial barrier to gene flow among the species we studied but act
as a corridor and refuge for these birds. However, analyses on higher
ranked community data suggest the mountains acted as a barrier in older
times, corresponding to the known diversification events in southeast
Asian avifauna.
In situ tailoring solid electrolyte interphase of three-dimensional Li metal electrode for enhanced Coulombic efficiency
Authors: Wang Jiangpeng , LANG FENG , Li Quan
Published: February 2023

Although three-dimensional (3D) host is effective in restricting Li
dendrite growth, problems associated with the unstable
electrode/electrolyte interphase becomes more severe due to increased
interfacial area that is intrinsic of the 3D structures, being a major
cause for the low Coulombic efficiency.While building a desirable solid
electrolyte interphase (SEI) serves as an effective solution to improve
the electrode/electrolyte interfacial stability, the 3D nature of the
electrode makes the task challenging.Herein,we demonstrated the in-situ
formation of SEI on chemically/structurally modified carbon cloth that
is used as the 3D host.We shown that ZnS/ZnO nanotube arrays uniformly
grown on the carbon cloth served as precursors for the in-situ formation
of Li2S/Li2O/LiZn containing artificial SEI. While Li2S and Li2O are
preferred components in SEI, Zn functions as lithiophilic site that
guides the uniform lithium deposition.The present work shed light on
effective design strategies for SEI formation on 3D electrode host with
controllable SEI composition.
Hysteroscopic and Laparoscopic finding in Infertile Women with proven Endometrial Tuberculosis
Authors: Mondal Rana , Jaiswal Neha , Bhave Priya
Published: February 2023

Background: Currently, none of the diagnostic procedures for
detecting female genital tuberculosis (FGTB) are 100 percent reliable,
and the same is true for endoscopic results. There are several studies
accessible on hysteroscopic and laparoscopic findings that are
suggestive of TB. However, no study to our knowledge summarises the
findings of laparoscopic and hysteroscopic examination in subfertile
female patients with biopsy, culture, or other laboratory test-proven
endometrial tuberculosis. Objective: Evaluation of
hysteroscopic and laparoscopic findings in subfertile women suffering
from proven endometrial tuberculosis. Materials and methods:
16,784 infertile women had a diagnostic hysterolaparoscopy between
February 2014 and June 2021, among which 1084 patients were prescribed
anti-tubercular medication based on the results of their findings;
however, only 309 individuals had endometrial tuberculosis verified via
positive on histopathology examination, AFB demonstration, Culture, and
GeneXpert MTB/RIF. We retrospectively observed the diagnostic
hysterolaparoscopy findings in those proven cases of subfertile women
suffering from FGTB. Results: The major findings on
hysteroscopy were periosteal fibrosis (209/309,67.63%), pale
endometrium(179/309,57.92%), and micro polyp(138/309,44.66%). Other
notable hysteroscopic findings were intrauterine adhesions
(88/309,28.47%), endometrial tubercle (78/309,25.24%), endometrial
polyp(54/309,14.88%), caseation(42/309,13.59%), focal
hyperemia(29/309,9.38%) and diffuse hyperemia(18/309,5.82%). The most
common finding on laparoscopy was abdominopelvic adhesions of various
grades (297/309,96.11%). The major findings of laparoscopy were
tubercle (155/309,50.16%), isthmo ampullary block (118/309,38.18%),
tubal diverticula (116/309,37.54%), hydrosalpinx (97/309,31.39%) and
TO mass (96/309,31.06%). 5.50% (17/300) had a normal appearance on
hysteroscopy, and 1.29% (4/309) had a normal-looking pelvis on
laparoscopy. Conclusions: In proven endometrial tuberculosis,
significant hysteroscopic findings are periosteal fibrosis, pale
endometrium, micro-polyp, and intrauterine adhesions, whereas major
laparoscopic findings are various grades of abdominal pelvic adhesions,
including perihepatic adhesions, miliary tubercle, isthmo ampullary
block, tubal diverticula, caseous material, and hydrosalpinx.
Tuberculosis should be considered if these signs are discovered during a
diagnostic work-up in infertile people.
Mononeuropathy Multiplex as An Uncommon Presentation of Intravascular Lymphoma: A Case Report
Authors: Ashtiani Bahram Haghi , Moghaddam Parichehr , Barzkar Farzaneh , Mehrjerdi Ali Zare , Almasi-Dooghaee Mostafa
Published: February 2023

A 64-year-old man presented with asymmetric paresthesia and subsequent
weakness of his feet and a 10-kg weight loss over 40 days.
Electrodiagnostic studies revealed distal axonal sensory-motor
polyneuropathy with ongoing axonal loss. A peroneal nerve biopsy showed
intravascular proliferation of CD-20 positive lymphocytes, which
suggested intravascular large B-cell lymphoma.
The first wave of SARS-CoV-2 infection among hospitalized children after the adjustment of prevention measures in Henan, China
Authors: Leng maodong , Yang Junmei
Published: February 2023

On December 7  of 2022, the province and the country
experienced a huge adjustment of the prevention and control measures
against SARS-CoV-2, which was called the ten actions. But we still
performed regular SARS-CoV-2 nucleic acid testing for hospitalized
patients before their admission, which could to some extent reflect the
infection rates of the total society. A total of 2212 cases and 439
positive cases were enrolled in the study. The infection rate increases
from the first to the third week, and then decreases from the third to
the eighth period. The infection rate of the eighth week returned nearly
to the rate of the first week. The adjustment on the prevention and
control measures resulted in rapid increase of SARS-CoV-2 infection rate
among hospitalized children through the first three weeks, and it took
nearly eight weeks for the infection to recover to the rate at the
beginning of the adjustment. Continuous monitoring of the infection is
required in the future to help reduce the infection.
Paralog switching facilitates euryhalinity: Ontogenetic, microevolutionary and macroevolutionary evidence
Authors: Colby Rebecca , McCormick SD , Velotta Jonathan , Jockusch Elizabeth , Schultz Eric
Published: February 2023

Euryhalinity is present in diverse aquatic taxa and requires flexible
osmoregulation to field the challenges posed by differing salinities.
Na, K-ATPase (NKA) is a ubiquitous
ion pump in the gills of fishes and, for some species, paralogs of the
catalytic α-subunit (NKA α1a and α1b) exhibit reciprocal expression
between fresh- and seawater, termed paralog-switching. We investigated
the expression and evolution of NKA paralogs in Alewife (Alosa
pseudoharengus), a euryhaline and migratory fish. Comparisons between
landlocked and diadromous life history forms and migrant and pre-migrant
ontogenetic stages were used to study shifts in NKA paralog expression
related to freshwater or seawater specialization. We exposed juvenile
diadromous and landlocked alewives to freshwater (0 ppt) and seawater
(30 ppt) for 2, 5, and 15 days. Additionally, we sampled migrant and
pre-migrant alewives from the natal freshwater environment or after 24
hours in seawater. Diadromous Alewife exhibited salinity-dependent
paralog switching, and the freshwater-specialized landlocked life
history form showed greater upregulation of NKA α1b in seawater. Migrant
Alewife showed a loss of freshwater readiness traded for seawater
specialization through greater reliance (via upregulation) on NKA α1a in
freshwater. Molecular phylogenies show Alewife NKA paralogs originated
independently of paralogs in salmonids and other members of
Euteleosteomorpha. This study demonstrated that NKA paralog switching is
tied to halohabitat profile and that duplications of the ancestral NKA
gene provided the substrate for multiple, independent molecular
solutions for supporting a diadromous life history.
Ecc-RCNN: An Efficient and High-accuracy Object Detection Framework for Transmission Line Defect Identification
Authors: Li Yaocheng , Xu Yongpeng , Sun Weihao , Qian Qinglin , Li Zhe , jiang xiuchen
Published: February 2023

In order to improve the accuracy of image-based transmission line defect
detection, while reducing the computational complexity and the high
demand on chip performance, an object detection framework is proposed,
which aims to improve model performance without increasing the scale of
the model and the amount of calculation. We first introduce an efficient
feature fusion module to combine different-level semantic features in
nonlinear transformations. It includes channel-level hierarchy features,
linear projection and residual mappings to gather task-oriented features
across different spatial locations and scales. Then a context
information modelling module is proposed to extract features around the
target objects, which further increases the detection accuracy. Finally,
an Intersection-over-Union-based training examples sampling strategy is
adopted to alleviate the class imbalance problem. Experiments on our
dataset show that the proposed method, with a similar number of model
parameters, has an accuracy improved by 8.1% compared to the baseline,
and outperforms all the competitors in the area of transmission line
defect detection.
Role of Behavior Change Communication in Acute Respiratory Infection Surveillance in Internally Displaced Persons' Camps of Taluka Kingri District Khairpur-Mirus, Sindh Province Pakistan, August-September 2022
Authors: Memon Fahad , Memon Khalida , Memon Naveed , Syed Mohammad , Qureshi Samreen , Hussain Mudassar , Malik Muhammad , Khan Mumtaz , Ikram Aamer
Published: February 2023

BACKGROUND: In 2022, monsoon rain and flood affected 23 districts in
Sindh, Pakistan displacing six-million-people.
Internally-displaced-persons-(IDPs) were prone to infectious-
disease-outbreaks and acute-respiratory-infection-(ARI). Objectives of
this study were to assess association between
socio-demographic-characteristics, occurrence of ARI and compare
pre-&-post health-education-effects on level of awareness regarding
ARI. METHODS: Comparative cross-sectional-study carried-out in
medical-camps of randomly selected seven-villages of
District-Kharipur-Mirus. The 560 subjects were recruited through
consecutive sampling. Health-education-sessions were taken &
Behavior-Change-Communication tool (BCC) was applied. Epi-info was used
to calculate frequencies, p-value and chi-square test was applied to
determine associations RESULT: 560-patients were treated in
medical-camps with different types of ARI. Among them females were
56%(n=312), ARI-cases were more predominate factor reported in
medical-camps 41%(n=229) besides tonsillitis 25%(n=140),
bronchitis13%(n=72), diarrhea11%(n=62) and severe-pneumonia4%(n=22).
Before health-education-session 94%(n=529) affectees had no knowledge
regarding ARI-prevention. The 57%(n=320) belonged to poor-family. After
post-health-education-sessions 89%(n=499) peoples were sensitized
regarding ARI-prevention methods. Among socio-demographic-variables,
age-group(10-19years), hygiene-status & socioeconomic-status was
strongly statistically associated with occurrence of
upper-acute-respiratory-infection (p=0.01, p=0.04 & p=0.001)
respectively. We didn’t find significant association between
previous-history & occurrence of ARI (p=0.12). There was statistically
significant difference between pre-&-post application of BCC tool on
the level of awareness among IDPs(p=0.03). CONCLUSION: There is great
impact of health-education on cumulatively raising level of awareness
among displaced-population regarding control of infectious-diseases like
ARI. Second decade of age, low socio-economic-status &
bad-hygiene-status was identified as high-risk factors which can be
addressed through health- education & behavior-change-communication.
Nanoscale Simulation of the Thylakoid Membrane Response to Extreme Temperatures
Authors: V Josh Vermaas , Kulke Martin , M Sarathi Weraduwage , Sharkey Thomas
Published: February 2023

The thylakoid membrane is in a temperature-sensitive equilibrium that
shifts repeatedly during the life cycle in response to ambient
temperature or solar irradiance. Plants respond to seasonal temperature
by changing their thylakoid lipid composition, while a more rapid
mechanism for short-term heat exposure is required. The emission of the
small organic molecule isoprene has been postulated as one such possible
rapid mechanism. The protective mechanism of isoprene is not known, but
some plants emit isoprene during periods of high-temperature stress. In
this work, we investigate the dynamics and structure for lipids within a
thylakoid membrane at different temperatures and varied isoprene content
using classical molecular dynamics simulations. The results are compared
with experimental findings from across the literature for
temperature-dependent changes in the lipid composition and shape of
thylakoids. We find that the surface area, volume, and flexibility of
the membrane, as well as the lipid diffusion, increase with temperature,
while the membrane thickness decreases. Saturated thylakoid 34:3
glycolipids derived from eukaryotic synthesis pathways exhibit
significantly different dynamics than lipids from prokaryotic synthesis
paths, which could explain the upregulation of specific lipid synthesis
pathways at different temperatures. Increasing isoprene concentration
was not observed to have a significant thermoprotective effect on the
thylakoid membranes, and that isoprene readily permeated the membrane
models tested here.
Surgeon perspectives of three-dimensional endoscopy in pediatric otolaryngology: A qualitative study
Authors: McNeely Brendan D. , Fitzpatrick Nick , Leitmeyer Katharina , Pauwels Julie , Chadha Neil
Published: February 2023

KEY POINTS 1. This is the first study to use a qualitative methodology
to assess the potential advantages and disadvantages of the application
of 3D endoscopes in pediatric otolaryngology surgery. 2. Open-ended,
structured interviews were conducted with six pediatric Otolaryngologist
operating at a tertiary pediatric centre, with a minimum one year of
experience using a 3D endoscopy system. 3. Thematic analysis of the
surgeon’s responses identified 3D endoscopy to provide improved surgical
field visualization which thus served as a valuable teaching tool. 4.
The surgeons interviewed found 3D endoscopy to improve surgical outcomes
in pediatric airway surgery, particularly in surgeries involving the
larynx. 5. Further quantitative evaluation of patient outcomes could
delineate the precise clinical role 3D endoscopy may hold in future
pediatric Otolaryngology practice.