bluuebunny/crossref_metadata_2025 huggingface dataset:
Threedimensionally patterned, hierarchically and anisotropically structured bacterial cellulose
Authors: Gmach Yvonne , Van Opdenbosch Daniel
Published: February 2023

Structuring cellulosic materials is an important step towards realizing emerging technologies, such as so-called engineered living materials, and improving on established ones, such as tissue engineering. In this work, we present a route for the preparation of cellulose monoliths exhibiting a three-dimensional pattern on the macroscopic scale, together with structural anisotropy in the cellulose fiber level. This was achieved by rheotactic growth, i.e. under flowing medium, of bacterial cellulose over a 3D-printed dissolvable template. The surrounding setup was realized using commercially available components. Here, we report on and discuss structural properties of cellulose monoliths obtained by this process, such as shrinkages during processing, the strut densities of 50 mg cm−3, preferred orientations of cellulose within the struts, and the pore size distributions, which were determined from nanoscale-precision silica replica.
Development of handheld induction heaters for magnetic fluid hyperthermia applications and in-vitro evaluation on ovarian and prostate cancer cell lines
Authors: Castro-Torres Jorge L , Méndez Janet , Torres-Lugo Madeline , Juan Eduardo
Published: February 2023

Objective: Magnetic fluid hyperthermia (MFH) is a still experimental technique found to have a potential application in the treatment of cancer. The method aims to reach around 41 °C–47 °C in the tumor site by exciting magnetic nanoparticles with an externally applied alternating magnetic field (AMF), where cell death is expected to occur. Applying AMFs with high spatial resolution is still a challenge. The AMFs from current and prospective MFH applicators cover relatively large areas; being not suitable for patients having metallic implants near the treatment area. Thus, there will be a clinical need for smaller magnetic field applicators. To this end, a laparoscopic induction heater (LIH) and a transrectal induction heater (TRIH) were developed. Methods: Miniature ‘pancake’ coils were wound and inserted into 3D printed enclosures. Ovarian (SKOV-3, A2780) and prostate (PC-3, LNCaP) cancer cell lines were used to evaluate the instruments’ capabilities in killing cancer cells in vitro, using Synomag®-D nanoparticles as the heat mediators. NIH3T3 normal cell lines were also used with both devices to observe if these cells tolerated the conditions applied. Results: Magnetic field intensities reached by the LIH and TRIH were 42.6 kA m−1 at 326 kHz and 26.3 kA m−1 at 303 kHz, respectively. Temperatures reached in the samples were 41 °C by the LIH and 43 °C by the TRIH. Both instruments successfully accomplished killing cancer cells, with minimal effects on normal cells. Conclusion: This work presents the first line of handheld medical induction heaters and have the potential to be a complement to existing cancer therapies. Significance: These instruments could enable the development of MFH modalities that will facilitate the clinical translation of this thermal treatment.
In search of Pca21 phase ferroelectrics
Authors: Mao Ge-Qi , Yuan Jun-Hui , Xue Kan-Hao , Huang Jinhai , Yang Shengxin , Miao Xiangshui
Published: February 2023

In recent years, hafnia-based ferroelectrics have attracted enormous attention due to their capability of maintaining ferroelectricity below 10 nm thickness and excellent compatibility with microelectronics flow lines. However, the physical origin of their ferroelectricity is still not fully clear, although it is commonly attributed to a polar Pca21 orthorhombic phase. The high-temperature paraelectric phases (the tetragonal phase or the cubic phase) do not possess a soft mode at the Brillouin zone center, thus the ferroelectric distortion has to be explained in terms of trilinear coupling among three phonon modes in the tetragonal phase. It is necessary to explore new materials with possible ferroelectricity due to the polar Pca21 phase, which in turn should be very helpful in evaluating the microscopic theory for ferroelectric hafnia. In this work, based on the idea of the Materials Genome Engineering, a series of hafnia-like ferroelectrics have been found, exemplified by LaSeCl, LaSeBr, LuOF and YOF, which possess adequate spontaneous polarization values and also relatively favorable free energies for the polar phase. Their common features and individual differences are discussed in detail. In particular, a promising potential ferroelectric material, Pca21 phase LuOF, is predicted and recommended for further experimental synthesis and investigation.
Practical Guide to Honest Causal Forests for Identifying Heterogeneous Treatment Effects
Authors: Jawadekar Neal , Kezios Katrina , Odden Michelle C , Stingone Jeanette A , Calonico Sebastian , Rudolph Kara , Zeki Al Hazzouri Adina
Published: February 2023

“Heterogeneous treatment effects” is a term which refers to conditional average treatment effects (i.e., CATEs) that vary across population subgroups. Epidemiologists are often interested in estimating such effects because they can help detect populations that may particularly benefit from or be harmed by a treatment. However, standard regression approaches for estimating heterogeneous effects are limited by preexisting hypotheses, test a single effect modifier at a time, and are subject to the multiple-comparisons problem. In this article, we aim to offer a practical guide to honest causal forests, an ensemble tree-based learning method which can discover as well as estimate heterogeneous treatment effects using a data-driven approach. We discuss the fundamentals of tree-based methods, describe how honest causal forests can identify and estimate heterogeneous effects, and demonstrate an implementation of this method using simulated data. Our implementation highlights the steps required to simulate data sets, build honest causal forests, and assess model performance across a variety of simulation scenarios. Overall, this paper is intended for epidemiologists and other population health researchers who lack an extensive background in machine learning yet are interested in utilizing an emerging method for identifying and estimating heterogeneous treatment effects.
Invited Commentary: To Make Long-Term Gains Against Infection Inequity, Infectious Disease Epidemiology Needs to Develop a More Sociological Imagination
Authors: Zelner Jon , Naraharisetti Ramya , Zelner Sarah
Published: February 2023

In a recent article in the Journal, Noppert et al. (Am J Epidemiol. 2023;192(3):475–482) articulated in detail the mechanisms connecting high-level “fundamental social causes” of health inequity to inequitable infectious disease outcomes, including infection, severe disease, and death. In this commentary, we argue that while intensive focus on intervening mechanisms is welcome and necessary, it cannot occur in isolation from examination of the way that fundamental social causes—including racism, socioeconomic inequity, and social stigma—sustain infection inequities even when intervening mechanisms are addressed. We build on the taxonomy of intervening mechanisms laid out by Noppert et al. to create a road map for strengthening the connection between fundamental cause theory and infectious disease epidemiology and discuss its implications for future research and intervention.
Screening for Primary Aldosteronism Among Hypertensive Adults with Obstructive Sleep Apnea: A Retrospective Population-Based Study
Authors: Hundemer Gregory L , Imsirovic Haris , Kendzerska Tetyana , Vaidya Anand , Leung Alexander A , Kline Gregory A , Goupil Rémi , Madore François , Agharazii Mohsen , Knoll Greg , Sood Manish M
Published: February 2023

BACKGROUND

Hypertension plus obstructive sleep apnea (OSA) is recommended in some guidelines as an indication to screen for primary aldosteronism (PA), yet prior data has brought the validity of this recommendation into question. Given this context, it remains unknown whether this screening recommendation is being implemented into clinical practice.

METHODS

We conducted a population-based retrospective cohort study of all adult Ontario (Canada) residents with hypertension plus OSA from 2009 to 2020 with follow-up through 2021 utilizing provincial health administrative data. We measured the proportion of individuals who underwent PA screening via the aldosterone-to-renin ratio by year. We further examined screening rates among patients with hypertension plus OSA by the presence of concurrent hypokalemia and resistant hypertension. Clinical predictors associated with screening were assessed via Cox regression modeling.

RESULTS

The study cohort included 53,130 adults with both hypertension and OSA, of which only 634 (1.2%) underwent PA screening. Among patients with hypertension, OSA, and hypokalemia, the proportion of eligible patients screened increased to 2.8%. Among patients ≥65 years with hypertension, OSA, and prescription of ≥4 antihypertensive medications, the proportion of eligible patients screened was 1.8%. Older age was associated with a decreased likelihood of screening while hypokalemia and subspecialty care with internal medicine, cardiology, endocrinology, or nephrology were associated with an increased likelihood of screening. No associations with screening were identified with sex, rural residence, cardiovascular disease, diabetes, or respirology subspecialty care.

CONCLUSIONS

The population-level uptake of the guideline recommendation to screen all patients with hypertension plus OSA for PA is exceedingly low.
Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state
Authors: Martín-Suárez Soraya , Cortes Jesús María , Bonifazi Paolo
Published: February 2023

Epilepsy, characterized by recurrent unprovoked seizures resulting from a wide variety of causes, is one of the world’s most prominent neurological disabilities. Seizures, which are an expression of neuronal network dysfunction, occur in a positive feedback loop of concomitant factors, including neuro-inflammatory responses, where seizures generate more seizures. Among other pathways involved in inflammatory responses, the JAK/STAT signalling pathway has been proposed to participate in epilepsy.

Here, we tested an in vitro model of temporal lobe epilepsy, with the hypothesis that acute blockage of STAT3-phosphorylation during epileptogenesis would prevent structural damage in the hippocampal circuitry and the imprinting of both neural epileptic activity and inflammatory glial states. We performed calcium imaging of spontaneous circuit dynamics in organotypic hippocampal slices previously exposed to epileptogenic conditions through the blockage of GABAergic synaptic transmission.

Epileptogenic conditions lead to epileptic dynamics imprinted on circuits in terms of increased neuronal firing and circuit synchronization, increased correlated activity in neuronal pairs and decreased complexity in synchronization patterns. Acute blockage of the STAT3-phosphorylation during epileptogenesis prevented the imprinting of epileptic activity patterns, general cell loss, loss of GABAergic neurons and the persistence of reactive glial states. This work provides mechanistic evidence that blocking the STAT3 signalling pathway during epileptogenesis can prevent patho-topological persistent reorganization of neuro-glial circuits.
Through the “Magic Mirror”: Adapting Angela Carter’s Japanese Writings for the Silver Screen
Authors: Crofts Charlotte
Published: February 2023

This article outlines the development of a feature-length screenplay adaptation of Angela Carter’s short story “Flesh and the Mirror,” situating it within a critical discussion of her metaleptic narrative strategies and the challenges of translating them to the screen. The screenplay incorporates Carter’s Japanese short stories and journalism, which are said to be her most autobiographical writings. The article explores Carter’s attitude to life writing and highlights the dangers of a straightforward biographical adaptation, contextualizing her Japanese writings within her wider engagement with Japanese literature and the I-novel. It demonstrates how the screenplay aims to emulate Carter’s playful experimentation with narrative form, overlapping metaphors of magic mirrors, puppetry, theater, and film sets, attempting a delicate balancing act of transposing Carter’s “literary gymnastics” to the silver screen.
Breeding phase and outcome determine space use in European rollers Coracias garrulus prior to migration
Authors: Monti Flavio , Barišić Sanja , Cannarella Sebastian , Ćiković Davor , Tutiš Vesna , Kralj Jelena , Catoni Carlo
Published: February 2023

The breeding period is a demanding and time-constrained phase for migratory bird species. Breeding outcome and duration can interact with the extent and duration of post-breeding movements, resulting in individual differences in space use ultimately influencing later stages of the annual cycle. We present space-use and home range estimates during the breeding season for 21 European rollers Coracias garrulus tracked between 2018 and 2022, in Italy and Croatia. Using high-resolution spatial GPS data coupled with regular nest-box monitoring, we analyzed differences in space use during the incubation/nestling period versus post-breeding period prior to migration, accounting for the breeding outcome (successful vs. failure). We found that adult movements were strongly reduced during the first phase, whereas increased in the post-breeding phase, especially for failed breeders. Successful breeders remained in the surroundings of the nest site, whereas unsuccessful ones tended to abandon the nest and visit distant areas (up to 500 km) for long periods (60.5 ± 6.2 days). Breeding outcome did not influence the departure date of autumn migration, suggesting that failed breeders used this period for exploratory movements but not for advancing the onset of migration. Such exploratory movements may be functional to prospect and inform settlement decisions in failed breeders in search of new breeding opportunities and may be particularly important in migratory species, which generally have a limited period to gather information prior to autumn migration. The study demonstrates the need to investigate seasonal movements in different populations and the potential importance of prospecting post-breeding movements for long-distance migratory species.
Clinical profiles and intraoperative identification of complex glands in stage I lung adenocarcinoma
Authors: Ding Qifeng , Chen Donglai , Shen Shanshan , Wang Wei , Chen Liangyan , Duan Shanzhou , Chen Yongbing
Published: February 2023

OBJECTIVES

This study aimed to investigate the potential of complex glandular patterns (CGP) in lymph node micrometastasis (LNMM) and to determine the clinical beneficiaries in stage I lung adenocarcinoma (LUAD) with CGP. Meanwhile, the feasibility of detecting CGP on frozen section was also evaluated.

METHODS

We retrospectively analysed the clinicopathological characteristics of 848 pathologic-stage I LUADs. A logistic regression model and a Cox proportional-hazards model were conducted to define the risk factors for LNMM and survival respectively. Furthermore, 5 pathologists reviewed frozen sections of 100 LUADs independently.

RESULTS

The logistic regression model indicated that CGP [odds ratio 3.89, 95% confidence interval (CI) 2.46–6.15; P < 0.001] was an independent predictor of the presence of LNMM. Subgroup analysis revealed that CGP-present/LNMM-positive LUAD had the highest risk of both loco-regional and distant recurrence. Moreover, adequate lymphadenectomy [recurrence-free survival: hazard ratio (HR) 0.61, 95% CI 0.40–0.95; P = 0.028; overall survival: HR 0.64, 95% CI 0.41–0.99; P = 0.043] and adjuvant chemotherapy (recurrence-free survival: HR 0.30, 95% CI 0.18–0.52; P < 0.001; overall survival: HR 0.33, 95% CI 0.19–0.57; P < 0.001) brought survival benefits to CGP-present patients, especially to CGP-present/LNMM-positive subgroup. Across the 5 pathologists, sensitivity ranged from 59 to 68% and specificity ranged from 79 to 83%, with moderate diagnostic agreement and high interobserver agreement for detecting CGP on frozen section.

CONCLUSIONS

LNMM was more frequently observed in stage I LUAD with CGP. Adequate lymphadenectomy and adjuvant chemotherapy were associated with improved survival in CGP-present patients, especially in CGP-present/LNMM-positive subgroup. Additionally, it is feasible to identify CGP on frozen section intraoperatively.
Solutions to address low response rates in online surveys
Authors: Shiyab Wa’ed , Ferguson Caleb , Rolls Kaye , Halcomb Elizabeth
Published: February 2023

Online surveys are increasingly popular in research given their cost-effectiveness and potential reach. However, low response rates remain a key contributor to bias and the overall quality of results. Having a well-designed survey, providing financial remunerations, sending personalized invitations, offering regular reminders, and using more than one recruitment strategy are evidence-based approaches to improve response rates. Given the potential for illegitimate responses to online surveys, approaches that minimize illegitimate participation are discussed.
Identification, genetic diversity, and pathogenicity ofRalstonia pseudosolanacearumcausing cigar tobacco bacterial wilt in China
Authors: Zhao Qian , Geng Ming-yan , Xia Chang-jian , Lei Ting , Wang Jie , Cao Chang-dai , Wang Jing
Published: February 2023

Ralstonia pseudosolanacearum, previously known as R. solanacearum species complex (RSSC) phylotypes I and III, is a plant pathogenic bacterium causing significant yield losses in economical crops. In the May of 2020 and 2021, cigar tobacco bacterial wilt was first observed in fields in Danzhou, Hainan Province, China. A total of eight bacterial isolates were isolated and identified as R. pseudosolanacearum with race 1, biovar III by 16S rRNA gene sequencing, Biolog, and host identification. The amino acid sequence showed that Hainan strains and 15 R. pseudosolanacearum reference strains from flue-cured tobacco in Shandong and Guizhou Provinces, all belonged to RS1000 type containing the avrA gene, only Guizhou strains also had the popP1 gene. On the basis of phylotype-specific multiplex PCR amplification, mismatch repair gene and endoglucanase gene-base tree, Hainan strains were identified as phylotype I sequevar 70, and showed stronger pathogenic capabilities on three different varieties than those reference strains. This is the first report of cigar tobacco bacterial wilt caused by R. pseudosolanacearum sequevar 70. The results revealed the diversity of RSSC in Nicotiana tabacum in China and provided useful information regarding the epidemiology of cigar tobacco wilt disease, as well as the breeding for disease resistance in local cigar tobacco.
Evaluation of the Occurrence of Hollows in Trees in Managed Forest in the Eastern Brazilian Amazon
Authors: dos Santos Misael Freitas , Figueiredo Filho Afonso , Gama João Ricardo Vasconcellos , Retslaff Fabiane Aparecida de Souza , da Costa Daniele Lima
Published: February 2023

This study proposed to generate information related to the abundance and the structural characteristics of hollows at the tree and species levels in an area of managed forest in the Amazon. A database was used that was composed of 29,899 trees from thirty-eight species that were inventoried, harvested, and measured in ten annual production units that were managed between 2008 and 2017 in the Tapajós National Forest, state of Pará, Brazil. The data was tabulated and reported in absolute and percentage values. Contingency tables were created to identify patterns of occurrence of hollows in commercial stems. A total of 24% of the harvested trees had hollows in at least one section of the commercial stem, and species had different propensities for hollow occurrence. It was found that the larger the tree diameter the greater the possibility for occurrence of hollows, and these hollows were proportionally larger. Most of the hollows in harvested trees were small. Patterns of occurrence in commercial stem hollows were observed, and these were dependent on tree species and size. Most trees had hollows distributed along the entire stem or only at the base of the stem.

Study Implications: The presence of hollows in managed native forest trees in the Amazon depends on the species, and trees with larger diameters have a greater probability of having hollows. Furthermore, trees with larger diameters have hollows that have larger diameters, lengths, and volumes. Commercial trees have different patterns of hollows along the stem, and these patterns are dependent on tree species and size. The results of this study will contribute to management of trees with hollows in the Amazon Forest as well as to serve as a base for future studies related to this theme.
Evolution of the Growth Hormone Gene Duplication in Passerine Birds
Authors: Rasband Shauna A , Bolton Peri E , Fang Qi , Johnson Philip L F , Braun Michael J
Published: February 2023

Birds of the order Passeriformes represent the most speciose order of land vertebrates. Despite strong scientific interest in this super-radiation, genetic traits unique to passerines are not well characterized. A duplicate copy of growth hormone (GH) is the only gene known to be present in all major lineages of passerines, but not in other birds. GH genes plausibly influence extreme life history traits that passerines exhibit, including the shortest embryo-to-fledging developmental period of any avian order. To unravel the implications of this GH duplication, we investigated the molecular evolution of the ancestral avian GH gene (GH or GH1) and the novel passerine GH paralog (GH2), using 497 gene sequences extracted from 342 genomes. Passerine GH1 and GH2 are reciprocally monophyletic, consistent with a single duplication event from a microchromosome onto a macrochromosome in a common ancestor of extant passerines. Additional chromosomal rearrangements have changed the syntenic and potential regulatory context of these genes. Both passerine GH1 and GH2 display substantially higher rates of nonsynonymous codon change than non-passerine avian GH, suggesting positive selection following duplication. A site involved in signal peptide cleavage is under selection in both paralogs. Other sites under positive selection differ between the two paralogs, but many are clustered in one region of a 3D model of the protein. Both paralogs retain key functional features and are actively but differentially expressed in two major passerine suborders. These phenomena suggest that GH genes may be evolving novel adaptive roles in passerine birds.
Age Differences in Everyday Emotional Experience: Testing Core Predictions of Socioemotional Selectivity Theory With the MIVA Model
Authors: Wirth Maria , Voss Andreas , Rothermund Klaus
Published: February 2023

Objectives

Emotional aging research is dominated by the idea of age-related improvements that result from shifts in motivation. Socioemotional selectivity theory (SST) proposes that as individuals age, they increasingly favor emotion-related goals and savor positive but avoid negative emotions. Previous age-comparative studies on everyday emotional experience typically were descriptive or studied the processes underlying emotional experience in isolation. We aimed at a more holistic approach to test hypotheses derived from SST regarding age-related differences in general emotional dispositions (i.e., anchoring), emotional reactivity, and emotion regulation by using a computational approach.

Methods

We applied our Model of Intraindividual Variability in Affect (MIVA) to data on everyday emotional experiences in an age-diverse sample (N = 378, age range 14–86 years). Parameter estimations were carried out within a Bayesian framework.

Results

Our results provide partial support for predictions derived from SST. Unexpectedly, anchoring showed a negative age trend, indicating a more positive affect disposition in younger, not older adults. Reactions to pleasant events showed no age trend. Reactivity to unpleasant events was highest in midlife and lower for younger and older adults. Consistent with SST, affect elicited by pleasant events was regulated less strongly by older adults and affect elicited by unpleasant events more strongly.

Discussion

As our results provide only partial support for SST, we revisit the phenomena that are at its foundations and provide suggestions on how to refine the theory.
A Brief Report on Living Arrangements Following Gray Divorce
Authors: Brown Susan L , Lin I-Fen , Mellencamp, PhD Kagan A
Published: February 2023

Objectives

We offer new insights on how older adults in the United States navigate the aftermath of gray divorce (i.e., divorce that occurs among adults aged 50+) by describing their living arrangements upon divorce and tracking the stability of these configurations over time. Living arrangements are important to decipher because they are linked to health, well-being, and longevity.

Methods

Using data from the 1998–2014 Health and Retirement Study, we uncovered patterns of U.S. older adult living arrangements upon divorce (N = 1,057), distinguishing among those who lived alone, lived with others, and lived with a new partner. Multinomial logistic regression models were estimated to assess how individual characteristics (demographics, marital biography, economic resources, health, and social ties) were associated with these configurations. Cumulative survival probabilities gauged the relative stability of these 3 living arrangements.

Results

About half of U.S. adults lived alone upon gray divorce, another one-third lived with others, and the remaining 14% lived with a new partner. Adults living with a new partner tended to exhibit the most advantaged sociodemographic profiles, whereas those living solo or with others were largely comparable. More than 70% of adults experienced a subsequent living arrangement transition if they lived with others upon divorce, versus just 50% of those living alone and only 30% of those with a new partner.

Discussion

After divorce, older adults reside in a range of living arrangements, some of which are more stable than others. Future work should address whether and how these arrangements and their durability are related to postdivorce adjustment.
Tackling the challenges of tectonic tremor localization using differential traveltimes and Bayesian inversion
Authors: Bombardier Madison , Dosso Stan E , Cassidy John F , Kao Honn
Published: February 2023

Episodic tremor and slip events in Northern Cascadia produce low-frequency, emergent seismic signals, often referred to as tectonic tremor. Methods designed to locate tremor face two challenges that increase the likelihood of producing low quality catalogues: first, signal arrival and duration are often poorly defined; second, high rates of tremor activity during episodes can cause multiple signals to be indiscernible from each other. In this paper, we present a new method of locating tectonic tremor using differential traveltimes from a waveform-envelope cross-correlation in a grid-based Bayesian inversion. To address the aforementioned challenges, we use a recently developed three-dimensional shear wave velocity model to compute traveltimes, and include processes to remove data outliers, estimate data error statistics, and quantify uncertainties within the Bayesian framework. Although this method is designed for tremor, to test the approach we consider a set of 58 local earthquakes between magnitudes −0.07 and 2.6 in the Southern Vancouver Island region and obtain well-constrained relocations. Residuals between official catalogue values and our relocations are quantized with respect to the 1 km grid resolution of the inversion, and average 2.7 km in epicentre and 5.2 km in depth. Analysis shows that depths of relocations are sensitive to horizontal variations and simplifications in velocity models. We then present our catalogue of tremor events during the 2004 episodic tremor and slip event beneath Southern Vancouver Island, Canada. Median uncertainties of tremor events quantified by 95 per cent credibility interval widths in a 1 km grid are 5 km and 9.km in horizontal and depth directions, respectively (1.2 km and 2.3 km using traditional standard deviation-based uncertainties). Comparison of our catalogue with previously published work demonstrates that our new method yields a good detection rate, a greater degree of epicentral clustering, and better depth resolution of tremor events. Catalogues produced using this new method may help to provide insight into the spatial extent of tremor, especially in depth, by yielding enhanced constraints on source locations on a regional scale.
Mental Health, Food Insecurity, and Economic Hardship among College Students during the COVID-19 Pandemic
Authors: Kim Youngmi , Murphy Jennifer
Published: February 2023

The mental health crisis among college students has become one of the most pressing issues, especially during the pandemic. Researchers discuss food insecurity as one of the leading causes of mental distress. The onset and continued impacts of the COVID-19 pandemic appear to compound food insecurity, economic hardship, and mental health. This study aims to understand the mental health of college students in relation to food insecurity and financial struggles to meet basic living expenses and debts during the pandemic. Authors collected survey data from college students in a public urban university in 2020 and conducted a multiple regression (N = 375). Evidence indicated that mental health became significantly worse after the pandemic onset. Mental health was significantly associated with food insecurity and multiple economic hardships, controlling for prepandemic mental health and other characteristics. The findings affirm that food insecurity and dire levels of economic hardship have devastating effects on the mental health of young adults. The article highlights the long-term implications of mental health affected by basic needs insecurity and the emergent need for integrated services and university–community partnerships.
Conjectural Positivity of Chern–Schwartz–MacPherson Classes for Richardson Cells
Authors: Kumar Shrawan
Published: February 2023

Following some work of Aluffi–Mihalcea–Schürmann–Su for the CSM classes of Schubert cells and some elaborate computer calculations by Rimanyi and Mihalcea, I conjecture that the CSM classes of the Richardson cells expressed in the Schubert basis have nonnegative coefficients. This conjecture was principally motivated by a new product $\square $ coming from the Segre-SM classes in the cohomology of flag varieties (such that the associated Gr of this product is the standard cup product) and the conjecture that the structure constants of this new product $\square $ in the standard Schubert basis have alternating sign behavior. I prove that this conjecture on the sign of the structure constants of $\square $ would follow from my above positivity conjecture about the CSM classes of Richardson cells.
Perceived Disability Discrimination and the Deficient Equality Act: Interpretive and Legislative Remedies
Authors: Connolly Michael
Published: February 2023

The Equality Act 2010 was intended to extend its cover to perceived discrimination, such as dismissing a turbaned Sikh barista under pressure from customers mistaking him for a Muslim. Such mistakes are rooted in stereotyping, fear and prejudice. Disability discrimination is particularly prone to these attitudes, but the Act’s inadequate drafting renders perceived disability discrimination claims exceptionally difficult. This paper suggests some innovative interpretive solutions, but ultimately recommends statutory reform.
Climate Change, Fundamental Rights, and Statutory Interpretation
Authors: Warnock Ceri , Preston Brian J
Published: February 2023

The climate change crisis demands a wholesale transformation of law. In this article, we consider one potential component of that transformation: the role that rights-protective statutory interpretation might play. Specifically, we analyse the transformative potential of the principle of legality. The principle of legality is a presumption of statutory interpretation that legislation should not be read as infringing fundamental common law rights in the absence of irresistibly clear statutory language. It enables courts to give statutory words their least rights-infringing meaning. The law in international fora and domestic jurisdictions now acknowledges that climate change will adversely affect human rights. We make the linkage between climate change, fundamental rights, and statutory interpretation and argue that the principle of legality may, in appropriate cases, be used to interpret legislation regulating the range of human activity, in a climate-protective way.
Whole-genome resequencing data support a single introduction of the invasive white pine sawfly,Diprion similis
Authors: Davis Jeremy S , Sim Sheina , Geib Scott , Scheffler Brian , Linnen Catherine R
Published: February 2023

Biological introductions are unintended “natural experiments” that provide unique insights into evolutionary processes. Invasive phytophagous insects are of particular interest to evolutionary biologists studying adaptation, as introductions often require rapid adaptation to novel host plants. However, adaptive potential of invasive populations may be limited by reduced genetic diversity—a problem known as the “genetic paradox of invasions.” One potential solution to this paradox is if there are multiple invasive waves that bolster genetic variation in invasive populations. Evaluating this hypothesis requires characterizing genetic variation and population structure in the invaded range. To this end, we assemble a reference genome and describe patterns of genetic variation in the introduced white pine sawfly, Diprion similis. This species was introduced to North America in 1914, where it has rapidly colonized the thin-needled eastern white pine (Pinus strobus), making it an ideal invasion system for studying adaptation to novel environments. To evaluate evidence of multiple introductions, we generated whole-genome resequencing data for 64 D. similis females sampled across the North American range. Both model-based and model-free clustering analyses supported a single population for North American D. similis. Within this population, we found evidence of isolation-by-distance and a pattern of declining heterozygosity with distance from the hypothesized introduction site. Together, these results support a single-introduction event. We consider implications of these findings for the genetic paradox of invasion and discuss priorities for future research in D. similis, a promising model system for invasion biology.
Constraints on extragalactic background light using TeV observations of BL Lacertae objects
Authors: Qin Longhua , Wang Jiancheng , Gao Quangui , Na Weiwei , Li Huaizhen , Wang Ao , Yang Chuyuan , Yang Jianping
Published: February 2023

The extragalactic background light (EBL) in the infrared to ultraviolet bands partly absorbs very high energy (VHE; E ≥ 100 GeV) γ-ray photons travelling over cosmological distances via pair production. In this paper, to get stronger constraints on EBL, we use the deliberate selection of the EBL model and data of five BL Lacs with better statistics and the harder spectra to limit the EBL density and the radiation mechanism of BL Lacs. We constrain the upper limit of the EBL density by fitting the spectral energy distributions of TeV BL Lacs and find that our results are compatible with the published measurement, reaching 50 $\rm {nW \,m^{-2} \,sr^{-1}}$. We also obtain that the EBL is not necessarily transparent to VHE photons. We fix the intrinsic spectral index Γi of TeV BL Lacs as 1.0 and 1.5 under observation evidence and model assumption. Comparing the EBL density given by galaxy count and Spitzer observations, we then obtain that 1ES 1101−232 has Γi ≤ 1.0 and 1ES 0229+200 should have Γi not harder than 1.0. We demonstrate that the common radiation assumption of BL Lacs, in which the Γi is softer than 1.5, should be revisited. Furthermore, we propose that the upper EBL density could be given by fitting the hardest energy spectra of TeV BL Lacs.
Evaluating the jet/accretion coupling of Aql X-1: probing the contribution of accretion flow spectral components
Authors: Fijma S , van den Eijnden J , Degenaar N , Russell T D , Miller-Jones J C A
Published: February 2023

The coupling between radio and X-ray luminosity is an important diagnostic tool to study the connection between the accretion inflow and jet outflow for low-mass X-ray binaries (LMXBs). The radio/X-ray correlation for individual neutron star (NS) LMXBs is scattered, whereas for individual black hole (BH) LMXBs a more consistent correlation is generally found. Furthermore, jet quenching is observed for both types of LMXBs, but it is unclear whether jets in NS-LMXBs quench as strongly as those in BH-LMXBs. While additional soft X-ray spectral components can be detected in NS-LMXB spectra due to the presence of the NS surface, disentangling the individual X-ray spectral components has thus far not been considered when studying the radio/X-ray coupling. Here we present eleven epochs of Swift/XRT observations matched with quasi-simultaneous archival radio observations of the 2009 November outburst of Aql X-1. We decompose the thermal and Comptonized spectral components in the Swift/XRT spectra, with the aim of studying whether the presence of additional thermal emission affects the coupling of the radio/X-ray luminosity. We find that there is no evidence of a significant thermal contribution in Swift/XRT spectra that could cause scatter in the radio/X-ray coupling. To explore the role of potential spectral degeneracies in the X-ray models and consider the improvements from including hard X-rays, we perform joint fits with quasi-simultaneous RXTE/PCA spectra. Follow-up research using more sensitive, broad-band X-ray observations and densely sampled near-simultaneous radio observations is required to study this in more detail.
Solar coronal magnetic field measurements using spectral lines available in Hinode/EIS observations: strong and weak field techniques and temperature diagnostics
Authors: Chen Yajie , Bai Xianyong , Tian Hui , Li Wenxian , Chen Feng , Yang Zihao , Yang Yang
Published: February 2023

Recently, it has been proposed that the magnetic-field-induced transition (MIT) in Fe x can be used to measure coronal magnetic field strengths. Several techniques, the direct line ratio technique and the weak and strong magnetic field techniques, are developed to apply the MIT theory to spectroscopic observations taken by EUV Imaging Spectrometer (EIS) onboard Hinode. However, the suitability of coronal magnetic field measurements based on the weak and strong magnetic field techniques has not been evaluated. Besides, temperature diagnostics is also important for measuring coronal magnetic field based on the MIT theory, but how to determine the accurate formation temperature of the Fe x lines from EIS observations still needs investigation. In this study, we synthesized emissions of several spectral lines from a 3D radiation magnetohydrodynamic model of a solar active region and then derived magnetic field strengths using different methods. We first compared the magnetic field strengths derived from the weak and strong magnetic field techniques to the values in the model. Our study suggests that both weak and strong magnetic field techniques underestimate the coronal magnetic field strength. Then we developed two methods to calculate the formation temperature of the Fe x lines. One is based on differential emission measure analyses, and the other is deriving temperature from the Fe ix and Fe xi line pairs. However, neither of the two methods can provide temperature determination for accurate coronal magnetic field measurements as those derived from the Fe x 174/175 and 184/345 Å line ratios. More efforts are still needed for accurate coronal magnetic field measurements using EIS observations.
The Ly α, C iv, and He iinebulae around J1000+0234: a galaxy pair at the centre of a galaxy overdensity atz = 4.5
Authors: Jiménez-Andrade E F , Cantalupo S , Magnelli B , Romano-Díaz E , Gómez-Guijarro C , Mackenzie R , Smolčić V , Murphy E , Matthee J , Toft S
Published: February 2023

Ly α λ1216 (Ly α) emission extending over $\gtrsim \, \rm 10\, kilo\,parsec\, (kpc)$ around dusty, massive starbursts at z ≳ 3 might represent a short-lived phase in the evolution of present-day, massive quiescent galaxies. To obtain empirical constraints on this emerging scenario, we present Ly α, C ivλ1550 (C iv), and He ii λ1640 (He ii) observations taken with the Multi-Unit Spectroscopic Explorer towards J1000+0234: a galaxy pair at z = 4.5 composed of a low-mass starburst (J1000+0234−South) neighbouring a massive Submillimeter Galaxy (SMG; J1000+0234−North) that harbours a rotationally supported gas disc. Based on the spatial distribution and relative strength of Ly α, C iv, and He ii, we find that star formation in J1000+0234−South and an active galactic nucleus in J1000+0234−North are dominant factors in driving the observed 40 kiloparsec-scale Ly α blob (LAB). We use the non-resonant He ii  line to infer kinematic information of the LAB. We find marginal evidence for two spatially and spectrally separated He ii regions, which suggests that the two-peaked Ly α profile is mainly a result of two overlapping and likely interacting H i clouds. We also report the serendipitous identification of three Ly α emitters spanning over a redshift bin Δz ≤ 0.007 (i.e. $\lesssim 380\, \rm km\, s^{-1}$) located at $\lesssim 140\, \rm kpc$ from J1000+0234. A galaxy overdensity analysis confirms that J1000+0234 lies near the centre of a Megaparsec-scale galaxy overdensity at z = 4.5 that might evolve into a galaxy cluster at z = 0. The properties of J1000+0234 and its large-scale environment strengthen the link between SMGs within LABs, tracing overdense regions, as the progenitors of local massive ellipticals in galaxy clusters.
Binary formation through gas-assisted capture and the implications for stellar, planetary, and compact object evolution
Authors: Rozner Mor , Generozov Aleksey , Perets Hagai B
Published: February 2023

Binary systems are ubiquitous and their formation requires two-body interaction and dissipation. In gaseous media, interactions between two initially unbound objects could result in gas-assisted binary formation, induced by a loss of kinetic energy to the ambient gas medium. Here, we derive analytically the criteria for gas-assisted binary capture through gas dynamical friction dissipation. We validate them with few-body simulations and explore this process in different gas-rich environments: gas-embedded star-forming regions (SFR), gas-enriched globular clusters, active galactic nucleus (AGN) discs, and protoplanetary discs. We find that gas-assisted binary capture is highly efficient in SFRs, potentially providing a main channel for the formation of binaries. It could also operate under certain conditions in gas-enriched globular clusters. Thin AGN discs could also provide a fertile ground for gas-assisted binary capture and in particular the formation of black hole/other compact object binaries, the production of gravitational-wave (GW) and other high-energy transients. Large-scale gaseous discs might be too thick to enable gas-assisted binary capture and previous estimates of the production of GW sources could be overestimated, and sensitive to specific conditions and the structure of the discs. In protoplanetary discs, while gas-assisted binary capture can produce binary Kuiper-belt objects, dynamical friction by small planetesimals is likely to be more efficient. Overall, we show that gas-assisted binary formation is robust and can contribute significantly to the binary formation rate in many environments. In fact, the gas-assisted binary capture rates are sufficiently high such that they will lead to multicaptures, and the formation of higher multiplicity systems.
Caregivers matter: Neurological vulnerability for pediatric brain tumor survivors
Authors: Moscato Emily L , Fisher Allison P , Pillay-Smiley Natasha , Salloum Ralph , Wade Shari L
Published: February 2023

Background

Pediatric brain tumor survivors (PBTS) are at risk of worse quality of life (QOL) due to the impact of neurotoxic treatments on the developing nervous system. Parenting factors such as protectiveness have been linked to worse QOL in childhood cancer survivors generally, but have yet to be explored for PBTS. We examined whether parenting behaviors moderated the association between neurotoxic treatment and QOL for PBTS.

Methods

PBTS (n = 40; ages 10–25) and their caregivers (n = 47) completed measures of parenting behaviors including warmth (support/connectedness) and psychological control (protectiveness) and QOL. We divided the sample into moderate/high and low neurotoxicity groups based on chart review using the Pediatric Neuro-Oncology Rating of Treatment Intensity and examined moderator effects.

Results

Survivor-reported primary caregiver warmth moderated the relationship between neurotoxicity and caregiver-reported QOL. Moderate/high neurotoxicity was associated with lower caregiver-reported QOL only when survivor-reported primary caregiver warmth was low, P = .02. Similar results were found for survivor-reported QOL. Caregiver-reported psychological control moderated the association between neurotoxicity and caregiver-reported QOL such that neurotoxicity only affected QOL at high levels of psychological control, P = .01.

Conclusions

Heightened associations between parenting and QOL in the context of neurotoxic treatments underscore the need to better support PBTS. Findings are consistent with research suggesting that family factors may be particularly important for children with other neurological insults. Limitations include cross-sectional design and a small/heterogeneous clinical sample with low ethnic/racial diversity. Prospective studies are needed to refine evidence-based screening and develop psychosocial intervention strategies to optimize QOL for PBTS and their families.
Dual-radical-based molecular anisotropy and synergy effect of semi-conductivity and valence tautomerization in a photoswitchable coordination polymer
Authors: Dai Jing-Wei , Li Yu-Qin , Li Zhao-Yang , Zhang Hai-Tao , Herrmann Carmen , Kumagai Shohei , Damjanović Marko , Enders Markus , Nojiri Hiroyuki , Morimoto Masakazu , Hoshino Norihisa , Akutagawa Tomoyuki , Yamashita Masahiro
Published: February 2023

Organic radicals are widely used as linkers or ligands to synthesize molecular magnetic materials. However, studies regarding the molecular anisotropies of radical-based magnetic materials and their multifunctionalities are rare. Herein, a photoisomerizable diarylethene ligand was used to form {[CoIII(3,5-DTSQ·–)(3,5-DTCat2–)]2(6F-DAE-py2)}·3CH3CN·H2O (o-1·3CH3CN·H2O, 6F-DAE-py2 = 1,2-bis(2-methyl-5-(4-pyridyl)-3-thienyl)perfluorocyclopentene), a valence-tautomeric (VT) coordination polymer. We directly observed dual radicals for a single crystal using high-field/-frequency (∼13.3 T and ∼360 GHz) electron paramagnetic resonance (EPR) spectroscopy along the c-axis, which was further confirmed by angle-dependent Q-band EPR spectroscopy. Moreover, a conductive anomaly close to the VT transition temperature was observed only when probes were attached at the ab plane of the single crystal, indicative of synergy between valence tautomerism and conductivity. Structural anisotropy studies and density functional theory (DFT) calculations revealed that this synergy is due to electron transfer associated with valence tautomerism. This study presents the first example of dual-radical-based molecular anisotropy and charge-transfer-induced conductive anisotropy in a photoswitchable coordination polymer.