bluuebunny/crossref_metadata_2025 huggingface dataset:
Materyalist Eğilim ve Tüketici Ahlakının Gösterişçi Tüketim Eğilimi Üzerindeki Etkisi
Authors: Tokmak Gizem
Published: November 2019

Günümüzde çoğu
insan için ürün satın almanın ardında yatan temel sebep, ürünün birincil
faydasını ifade eden rasyonel temelden uzaklaşmış durumdadır. İnsanlar
genellikle sosyal onay almak, statülerini göstermek, başkaları tarafından
takdir edilmek vb. sebepleri barındıran ikincil fayda için ürün satın alma
davranışı göstermektedir. Ürünün rasyonel faydasını yok sayıp ikincil faydasına
yönelik yapılan tüketim, gösterişçi tüketim olarak isimlendirilmektedir. Bu
çalışmada gösterişçi tüketim eğilimi üzerinde materyalist eğilim ve ahlaki
tüketim eğilimi ile birlikte demografik değişkenlerden cinsiyet ve aylık
harcama miktarının anlamlı bir etkisi olup olmadığının tespit edilmesi
amaçlanmıştır. Yapılan çoklu doğrusal regresyon analizi sonucunda, bahsi geçen
değişkenlerin gösterişçi tüketim üzerinde anlamlı etkisi olduğu; bağımsız
örneklem t testi sonucunda ise kadınlar ve erkekler arasında gösterişçi tüketim
eğilimi açısından anlamlı bir farklılık olduğu tespit edilmiştir.
Evaluation of Pharmacokinetic Interaction of Cilostazol with Metoclopramide after Oral Administration in Human
Authors: Kaukab Iram , Hussain Shah Syed Nisar , Kharaba Zelal , Murtaza Ghulam , Saad Abubaker Ali , Ahmad Shakeel
Published: November 2019

Background:

Metoclopramide is mainly metabolized by CYP2D6, CYP3A4, CYP2C19, and CYP1A2 enzymes, while cilostazol is also metabolized by CYP3A4, CYP2C19, and CYP1A2 enzymes.

Aim:

This study evaluates the effect of cilostazol on the pharmacokinetics of oral metoclopramide.

Methods:

This was a randomized, two-phase cross-over pharmacokinetic study separated by a 4-week wash-out time period, 12 healthy non-smoking volunteers received metoclopramide 20 mg as a single oral dose and after 4 weeks, cilostazol 100 mg twice daily for 4 days then with metoclopramide 20 mg on test day. Serial blood samples were analyzed by using a validated high-performance liquid chromatography-ultraviolet method to determine maximum plasma drug concentration (Cmax), time to reach (Tmax), and area under the curve (AUC0-∞) of metoclopramide.

Results:

Cilostazol increased the mean Cmax, AUC0-∞ and half-life (T1/2) of metoclopramide by 6%, 27% and by 0.79 %, respectively. In addition, Tmax of metoclopramide was delayed by cilostazol.

Conclusion:

The results showed delayed Tmax of metoclopramide by cilostazol, which could lead to the conclusion that cilostazol affects the absorption of metoclopramide. Both drugs when necessary to administer together must not be administered at the same time especially when given in gastroparesis patients.
Possible Pathways of Hepatotoxicity Caused by Chemical Agents
Authors: Mohi-ud-din Roohi , Mir Reyaz Hassan , Sawhney Gifty , Dar Mohd Akbar , Bhat Zulfiqar Ali
Published: November 2019

Background:

Liver injury induced by drugs has become a primary reason for acute liver disease and
therefore posed a potential regulatory and clinical challenge over the past few decades and has gained much attention.
It also remains the most common cause of failure of drugs during clinical trials. In 50% of all acute liver failure
cases, drug-induced hepatoxicity is the primary factor and 5% of all hospital admissions.

Methods:

The various hepatotoxins used to induce hepatotoxicity in experimental animals include paracetamol, CCl4,
isoniazid, thioacetamide, erythromycin, diclofenac, alcohol, etc. Among the various models used to induce hepatotoxicity
in rats, every hepatotoxin causes toxicity by different mechanisms.

Results:

The drug-induced hepatotoxicity caused by paracetamol accounts for 39% of the cases and 13% hepatotoxicity
is triggered by other hepatotoxic inducing agents.

Conclusion:

Research carried out and the published papers revealed that hepatotoxins such as paracetamol and carbon-
tetrachloride are widely used for experimental induction of hepatotoxicity in rats.
Spiro-Lactams as Novel Antimicrobial Agents
Authors: Alves Américo J.S. , Alves Nuno G. , Caratão Cátia C. , Esteves Margarida I.M. , Fontinha Diana , Bártolo Inês , Soares Maria I.L. , Lopes Susana M.M. , Prudêncio Miguel , Taveira Nuno , Pinho e Melo Teresa M.V.D.
Published: November 2019

Introduction:

Structural modulation of previously identified lead spiro-β-lactams with antimicrobial
activity was carried out.

Objective:

The main objective of this work was to synthesize and evaluate the biological activity of
novel spiro-lactams based on previously identified lead compounds with antimicrobial activity.

Methods:

The target chiral spiro-γ-lactams were synthesized through 1,3-dipolar cycloaddition reaction
of a diazo-γ-lactam with electron-deficient dipolarophiles. In vitro activity against HIV and Plasmodium
of a wide range of spiro-β-lactams and spiro-γ-lactams was evaluated. Among these compounds, one
derivative with good anti-HIV activity and two with promising antiplasmodial activity (IC50 < 3.5 µM)
were identified.

Results:

A novel synthetic route to chiral spiro-γ-lactams has been established. The studied β- and γ-
lactams were not cytotoxic, and three compounds with promising antimicrobial activity were identified,
whose structural modulation may lead to new and more potent drugs.

Conclusion:

The designed structural modulation of biologically active spiro-β-lactams involved the replacement
of the four-membered β-lactam ring by a five-membered γ-lactam ring. Although conformational
and superimposition computational studies revealed no significant differences between β- and γ-
lactam pharmacophoric features, the studied structural modulation did not lead to compounds with a
similar biological profile. The observed results suggest that the β-lactamic core is a requirement for the
activity against both HIV and Plasmodium.
Impact of SGLT Inhibitors on Multiple Organ Defects in Diabetes
Authors: Asrih Mohamed , Gariani Karim
Published: November 2019

Introduction:

Diabetes leads to multiple organ defects and cellular dysfunctions such as increased
expression of sodium-glucose like transporters (SGLTs). These transporters contribute to glucose
homeostasis through glucose reabsorption in the proximal renal tubule. When inhibited, it results
in reduced hyperglycemia, increased glucosuria and decreased HbA1c.

Aims:

This review article summarizes the positive and adverse effects of the three main SGLT inhibitors
used in Europe, on different organs with the aim of providing useful information to clinicians in
order to select the adapted SGLT inhibitor in regard to patient health problems.

Discussion:

Recently, SGLT pharmacological inhibitors have been developed to manage hyperglycemia
in diabetic patients. SGLT inhibitors like canagliflozin, dapagliflozin, empagliflozin were approved
by the Food and Drug Administration (FDA) in 2013 for use in Europe. Beyond their impact on glucose
re-uptake by the kidney, these inhibitors exert beneficial pleiotropic effects. Nevertheless, several
studies have recently warned the scientific community regarding adverse effects of these agents. Therefore,
clinicians should consider these effects to adapt the treatment regarding patients’ health.

Conclusion:

The use of SGLT inhibitor in the treatment of type 2 diabetes should be considered with
the perspective of general health state of the patient. In fact, SGLT inhibitors promote pleiotropic effects,
among which some are beneficial for certain organs while some are deleterious.
Creating a Smartphone App for Caregivers of Children With Atopic Dermatitis With Caregivers, Health Care Professionals, and Digital Health Experts: Participatory Co-Design (Preprint)
Authors: Xu Xiaomeng , Griva Konstadina , Koh Mark , Lum Elaine , Tan Woan Shin , Thng Steven , Car Josip
Published: November 2019

BACKGROUND

Smartphone apps could support patients and caregivers in disease self-management. However, as patients’ experiences and needs might not always align with clinical judgments, the eliciting and engaging of perspectives of all stakeholders in the smartphone app design process is of paramount importance.

OBJECTIVE

The aims of this study are to better understand the needs of and challenges facing caregivers and health care professionals (HCPs) who care for children with atopic dermatitis (AD) and to explore the desirable features and content of a smartphone app that would support AD self-management.

METHODS

This study adopted a qualitative participatory co-design methodology involving 3 focus group discussions: workshop one focused on caregivers; workshop two engaged with HCPs; and in the last workshop, caregivers and digital health experts were asked to design the wireframe prototype. The participants completed a sociodemographic questionnaire, a technology acceptance questionnaire, and a workshop evaluation form.

RESULTS

Twelve caregivers participated in the first workshop, and 10 HCPs participated in the second workshop. Eight caregivers and 4 digital health experts attended the third workshop. Three superordinate themes that reflected caregivers’ and HCPs’ challenges and needs were identified: empowerment by education, confusion over treatment, and emotional impact. Workshop participants also raised a series of suggestions on the features and contents of the AD self-management app, which informed the last co-design workshop, and described their needs and challenges. In the last workshop, the participants developed a wireframe prototype of the app following the identified requirements and recommendations.

CONCLUSIONS

The co-design approach was found to be a successful way of engaging with the participants, as it allowed them to express their creativity and helped us to articulate the root of the clinical problems. The co-design workshop was successful in creating and generating new ideas and solutions for smartphone app development.
Cancer Patients’ and Survivors’ Perceptions of the Calm App: Cross-Sectional Descriptive Study (Preprint)
Authors: Huberty Jennifer , Puzia Megan , Eckert Ryan , Larkey Linda
Published: November 2019

BACKGROUND

There is a need for tools to decrease cancer patients’ and survivors’ long-term symptom burden. Complementary strategies, such as meditation, can accompany pharmacologic therapy to improve symptoms. Although support programs with targeted content have wider reach, higher adherence, and greater impact, there are no consumer-based meditation apps designed specifically for cancer.

OBJECTIVE

This study aimed to gather information to advise the development of a cancer-specific meditation app in a small convenience sample of cancer patients and survivors who currently use the Calm app.

METHODS

Adult cancer patients and survivors who are Calm users (N=82) were recruited through the Daily Calm Facebook page. Participants completed a Web-based survey related to Calm app use and satisfaction, interest in and ideas for a cancer-specific Calm app, and demographic characteristics. Open-ended responses were inductively coded.

RESULTS

Participants were aged between 18 and 72 years (mean 48.60 years, SD 15.20), mostly female (77/82, 94%), white (65/79, 82%), and non-Hispanic (70/75, 93%), and reported using Calm at least 5 times per week (49/82, 60%). Although rates of satisfaction with current Calm components were high (between 65/82, 79% and 51/81, 63%), only 49% (40/82) of participants used guided meditations that they felt specifically helped with their cancer-related symptoms and survivorship, and 40% (33/82) would prefer more cancer-related content, with guided meditations for cancer-specific anxieties (eg, fear of recurrence; n=15) and coping with strong emotions (n=12) being the most common suggestions. A majority of participants (51/82, 62%) reported that they would be interested in becoming a member of a Calm cancer community (eg, in-app discussion boards: 41/46, 89%; and social media communities: 35/42, 83%). Almost half of the participants (37/82, 45%) reported that they would benefit from features that tracked symptoms in concurrence with app usage, but respondents were divided on whether this information should be shared with health care providers through the app (49/82, 60% would share).

CONCLUSIONS

Responses suggest ways in which the current Calm app could be adapted to better fit cancer patients’ and survivors’ needs and preferences, including adding cancer-specific content, increasing the amount of content focusing on coping with strong emotions, developing communities for Calm users who are cancer patients and survivors, and including features that track cancer-related symptoms. Given differences in opinions about which features were desirable or would be useful, there is a clear need for future cancer-specific apps to be customizable (eg, ability to turn different features on or off). Although future research should address these topics in larger, more diverse samples, these data will serve as a starting point for the development of cancer-specific meditation apps and provide a framework for evaluating their effects.
Internet of Things–Enabled Technologies for Weight Management in Children and Adolescents: Protocol for a Systematic Review (Preprint)
Authors: Lam Ching , Milne-Ives Madison , Van Velthoven Michelle Helena , Meinert Edward
Published: November 2019

BACKGROUND

Childhood obesity is a serious global issue, leading to increased medical spending on obesity-related diseases such as cardiovascular diseases and diabetes. There is a need for health care services that link health behavior to risk factors, such as diet and physical activity, and that provide better advice and feedback to users, which Internet of Things–enabled technologies could facilitate.

OBJECTIVE

The objective of the systematic review will be to identify available Internet of Things–enabled technologies for weight management of children and adolescents (users younger than 18 years). It will also aim to understand the use, effectiveness, and feasibility of these technologies.

METHODS

We will search the Medline, PubMed, Web of Science, Scopus, ProQuest Central, and IEEE Xplore Digital Library databases for studies published after 2010, using a combination of keywords and subject headings related to health activity tracking, youth, and Internet of Things. In addition, a Google search to identify grey literature will be conducted. Two authors will independently screen the titles and abstracts identified from the search and accept or reject the studies according to the study inclusion criteria. Any discrepancies will then be discussed and resolved. The quality of the included studies will be assessed using the Critical Appraisal Skills Programme (CASP) checklists. Data from included studies will be extracted into a predesigned form to identify the types of devices or apps, Internet of Things applications, and health outcomes related to weight management.

RESULTS

A preliminary search on Medline returned 484 results. The publication of the final systematic review is expected in mid-2020.

CONCLUSIONS

The effectiveness and feasibility of physical activity trackers and consumer wearables for different patient groups have been well reviewed, but there are currently no published reviews that look into these technologies in the wider Internet of Things context. This review aims to address this gap by examining Internet of Things–enabled technologies that are designed for youth weight management and thus inform further research and clinical studies to reduce childhood obesity.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/16930
Studi Komparasi Hasil Belajar Menggunakan Model Group Investigation dengan Model Picture And Picture Pada Mata Pelajaran Sains Kelas IV Sekolah Dasar
Authors: Arsil A , Haris Abd
Published: November 2019

This study aims to determine the differences in the average results of learning science the subject matter of the structure and function of plants between students whose learning uses a group investigation learning model with a model of picture and picture. This research includes field research, with the method used is comparative causal. The population of this study were all fourth grade students of SDN 45/1 Sridadi in the first semester of the 2014/2015 academic year, consisting of IV-A classes with 25 students, IV-B classes with 24 students. So the total population was 47 participants student. Because the population is less than 100, the entire population is sampled, with class IV-A consisting of 25 students as experimental class B and class IV-B consisting of 24 students as experimental class A. Data is collected by documentation method and test. The collected data were analyzed using statistical analysis of test differences in the average experimental class 1 (group investigation) and experimental class 2 (picture and picture) with the analysis of the two-party t-test test. Based on the results of the study it can be concluded that: the average science learning outcomes in the subject matter of plant structure and function of IV-A class students with the group investigation model is 84.44, while the average mathematics learning outcomes of students studying with a model of picture and picture is 77.29.
Meningkatkan Karakter Tanggung Jawab Belajar Siswa dengan Menggunakan Media Permainan Ular Tangga Pada Mata Pelajaran Matematika di Sekolah Dasar
Authors: Yantoro Y , Liansari Devi
Published: November 2019

The purpose of this study was to determine the increase in the character of student learning responsibilities by using snake ladder game media in class III mathematics subjects at SD Negeri 13/1 Bulu. This research method is class action research. In this research has three cycles, in one cycle carrying out two meetings. The procedures of this research are four, namely planning, implementation, observation and reflection. The results of this study showed that in the first cycle teacher activity reached 66.66%, student activities in playing snakes and ladders reached 66.66% and student learning responsibilities in this cycle reached 50.66%. while the second cycle of teacher activity reached 100%, student activity in performing snake play ladder 88.88%, and student learning responsibilities 68.96%. in the second cycle it has experienced an increase but has not reached the established criteria. Then continued in the third cycle with the percentage of teacher activity 100%, student activity 100% and student learning responsibilities have reached 81.8%. Based on the results of the research, it can be concluded that the use of snake ladder game learning media in the eyes of third grade mathematics learning at SDN 13/1 Muara Bulian can improve the character of student learning responsibilities.
Meningkatkan Pemahaman Materi FPB dan KPK melalui Sistem Pembagi Bertangga pada Siswa Kelas VI SDN 125/IX Simpang Selat
Authors: Rusnah R
Published: November 2019

This study aims to improve students' understanding of the biggest fellowship factor and the smallest multiple of alliances material by using a neighboring divider system in SDN 125 / IX Strait intersection. This type of research is Class Action Research. The method used is tests and observations. Based on the results of research and data analysis, it can be concluded that using a neighboring divider system can improve student learning outcomes on the subject of the biggest fellowship factor and the smallest multiple of alliances especially for Class VI SDN 125 / IX Simpang Selat Jambi Luar City District, Muaro Jambi Regency. This shows an increase in student learning outcomes with an average value in the first cycle with a value of 6.0 and in the second cycle with a value of 7.6.
Implementasi Pendidikan Karakter dalam Mata Pelajaran Pendidikan Kewarganegaraan pada Siswa Sekolah Dasar
Authors: Anderson Irzal , Sari Riana
Published: November 2019

The purpose of this study is to describe the implementation of character education in civic education subjects in class VI SDN 20/1 Jembatan Mas, Pemayung sub-district. This research is descriptive qualitative, namely research that can reveal facts comprehensively about the implementation of character education in civic education subjects in Class VI Students of SD Negeri 20/1 Jembatan Mas, Pemayung District. The subjects of this study were 2 grade VI teachers SDN 20/1 Mas bridge Pemayung sub-district with data collection techniques through interviews, observation, distributing questionnaires and documentation of supporting data. The results of this study show a description of the Implementation of Character Education in Citizenship Education Subjects in Class VI Students of SD Negeri 20 / I Jembatan Mas, Pemayung Subdistrict which has been well implemented through the stages of planning and implementing learning, and solutions to obstacles in the implementation of character education in PKn subjects.
Pengaruh Pemberian Hadiah Terhadap Hasil Belajar IPA Siswa Kelas IV Sekolah Dasar
Authors: Destrinelli D
Published: November 2019

Abstrak.Tujuan penelitian ini adalah untuk mengetahui hubungan antara manajemen kelas dengan hasil belajar siswa kelas IV SDN No. 139/I Sungai Buluh.Jenis penelitian ini adalah penelitian eksperimen dengan analisis kuantitatif, dengan subjek penelitian siswa kelas IV sebanyak 28 orang siswa. Metode analisis data  yang digunakan adalah analisis deskriptif kuantitatif. untuk mengetahui tingkat pemberian hadiah dengan hasil belajar siswa. Kemudian dilakukan interprestasi besaran nilai koefisien korelasi dan  uji hipotsesis penelitian melalui uji signifikan  koefisien korelasi dengan taraf kepercayaan α = 5% dengan ketentuan r-hitung ≥ r-tabel. Dari hasil penelitian diperoleh  hasil  256,714 dengan  1,93 pada tingkat signifikan 0,05 nilai  ≥   atau  256,714 dengan  1,93, karena  lebih besar  maka tolak  dan terima . Sementara itu untuk pengujian paired samples t-test yang menunjukkan pre test  2,179 dengan -4,238 dan post test  -1,980 dengan  -8,011 maka  ˃  sehingga hipotesis penelitian dapat diterima. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh yang signifikan antara pemberian hadiah terhadap hasil belajar IPA siswa kelas IV SDN No.139/1 Sungai Buluh.

 

Kata Kunci : Pemberian Hadiah, Hasil Belajar
Pengaruh Model Think Pair And Share Terhadap Hasil Belajar Matematika Siswa Sekolah Dasar
Authors: Shabrina Intan , Rahman Imas Kania , Asmahasanah Salati
Published: November 2019

Abstrak.Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Think Pair Share (TPS) terhadap hasil belajar matematika siswa kelas III pada konsep bangun datar sederhana di SDIT Al-Madinah Cibinong. Pendekatan yang digunakan dalam penelitian ini adalah penelitian deskriptif kuantitatif dengan jenis penelitian eksperimen, pada penelitian ini pemilihan sampel pada quasi experimental tipe Non Equivalent Control Group Design tidak dilakukan pemilihan sampel secara random melainkan dipilih sengaja oleh peneliti yaitu dengan masing-masing sampel kelas eksperimen 26 siswa dan kelas kontrol 27 siswa. Instrumen yang digunakan pada penelitian ini yaitu tes. Proses penerapan model pembelajaran Think Pair Share (TPS) pada mata pelajaran Matematika melalui tiga tahapan yaitu think, pair dan share. Think (Berpikir), Pair (Berpasangan) dan Share (Berbagi). Dalam proses pembelajaran dengan menerapkan model pembelajaran Think Pair Share (TPS) siswa sangat antusias sekali karena mereka memiliki waktu berpikir untuk menjawab pertanyaan dari guru, Jadi penerapan model pembelajaran Think Pair Share (TPS) dapat mempengaruhi hasil belajar matematika siswa kelas III pada mata pelajaran matematika dikatakan efektif dan terdapat perubahan atau peningkatan signifikan. Model pembelajaran Think Pair Share (TPS) ini bisa menjadi salah satu alternative model pembelajaran yang bisa diterapkan dalam proses pembelajaran.

 

Kata kunci: Think Pair Share, Hasil Belajar, Pembelajaran Matematika.
Strategi Guru Dalam Menumbuhkan Minat Belajar Sains Di Sekolah Dasar
Authors: Suhandi Andi
Published: November 2019

Abstrak. tujuan dari penelitian ini  adalah untuk mendeskripsikan strategi guru dalam menumbuhkan minat belajar sains siswa kelas IV SDN 28/I Malapari Kecamatan Muara Bulian. Metode penelitian ini adalah pendekatan kualitatif, menggunakan teknik pengumpulan data observasi, wawancara dan dokumentasi, sementara teknik analisa data meliputi reduksi data, penyajian data, serta penarikan kesimpulan. Uji keabsahan data menggunakan teknik trianggulasi. Berdasarkan hasil penelitian tentang strategi guru dalam menumbuhkan minat belajar sains siswa kelas IV SDN 28/I Malapari Kecamatan Muara Bulian adalah dengan memancing daya ingat dan kesiapan siswa, mengajak siswa bersama-sama mengamati obyek belajar, mencatat hasil pengamatan dan mendiskusikan hasil catatan siswa. Menyediakan waktu bagi siswa untuk bertanya dan memberi kesempatan kepada siswa lain menjawab pertanyaan tersebut. Menggunakan media pembelajaran nyata dalam bentuk utuh yang disesuaikan dengan topik pembahasan, berinteraksi dan memberikan perhatian pada siswa dalam pembelajaran. Menggunakan waktu secara efektif sejak membuka pelajaran, memulai dan mengawasi pembelajaran, hingga mengakhiri pembelajaran.

Kata Kunci : strategi guru, minat belajar sains
Pengalaman Terbaik Dalam Menumbuhkan Minat Membaca Buku Perpustakaan Pada Siswa Sekolah Dasar
Authors: Kuntarto Eko , N Sari
Published: November 2019

Abstrak. Tujuan dari  penelitian ini untuk mengetahui bagaimana cara menumbuhkan minat membaca buku-buku perpustakaan pada siswa di kelas V sekolah dasar. Jenis penelitian ini Best Pratices dengan pendekatan Qualitatif. Informan penelitian ini adalah siswa kelas V Sekolah Dasar 186/1 Sridadi, Instrumen pengumpulan data menggunakan lembar Observasi, wawancara dan Dokumentasi. Hasil dari penelitian ini adalah bahwa minat membaca siswa kelas V SDN 186/1 pada buku-buku perpustakaan tergolong tinggi. Untuk mengetahui minat membaca siswa tergolong tinggi atau rendah dapat kita lihat dari frekuensi dan kuantitas membaca serta kuantitas sumber bacaan menjelaskan bahwa jika minat seseorang tergolong tinggi maka orang tersebut akan selalu sering kali melakukan kegiatan membaca dan orang tersebut akan berusaha mencari sumber bacaan yang bervariatif. Penelitian ini dapat disimpulkan bahwa dalam menumbuhkan minat membaca siswa kelas V SDN 186/1 sridadi siswa-siswa diberikan perlakuan-perlakuan khusus agar minat membaca siswa tumbuh dan adapu perlakuan-perlakuan yang diberikan kepada siswa yaitu, 5 menit sebelum melakukan kegiatan belajar mengajar siswa di wajibkan untuk membaca, memberika hadiah (reward) berupa buku kepada siswa yang rajin mengunjungi perpustakaan, dan kemudian jadikan membaca sebagai kegiatan setiap hari.

Kata Kunci : Minat baca, Siswa Sekolah Dasar
Pengaruh Penggunaan Buku Cerita Bergambar Terhadap Motivasi Belajar Pada Siswa Sekolah Dasar
Authors: Emosda E
Published: November 2019

Abstrak. Tujuan penelitian ini ialah untuk mendeskripsikan kualitas motivasi belajar siswa sesudah mengunakan media buku cerita bergambar di Kelas III SD 43/I Desa Selat Kecamatan Pemayung. Rancangan penelitian yang digunakan adalah One Group Pretest-Postest Design. sampel dalam penelitian ini ialah siswa Kelas III SD 43/I Desa Selat Kecamatan Pemayung yang berjumlah 21 orang. Berdasarkan analisis data Kualitas motivasi belajar siswa pada tes awal dari jawaban angket dengan jumlah siswa 21 diperoleh jumlah keseluruhan 1331 sehingga memiliki rata-rata sebesar 63.38 memiliki criteria baik dan kualitas motivasi belajar siswa pada tes akhir dari jawaban angket dengan jumlah siswa 21 diperoleh jumlah keseluruhan 1369 sehingga memiliki rata-rata sebesar 65.19 memiliki criteria baik. Untuk pengujian dari uji hipotesis non parametik diatas di situ telah dihitung Z hitung= 1.96, jika α = 0.05, maka dengan n = 21 diperoleh nilai kritis 0.7734, sehingga z hitung > dari z tabel. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh penggunaan buku cerita bergambar terhadap motivasi belajar pada Siswa Kelas III SD 43/I Desa Selat Kecamatan Pemayung, dihitung Z hitung= 1.96, jika α = 0.05, maka dengan n = 21 diperoleh nilai kritis 0.7734, sehingga z hitung > dari z tabel.

Kata Kunci : Cerita Bergambar, Motivasi
Implementasi Nilai Toleransi Dalam Pembelajaran Tematik Di Sekolah Dasar
Authors: Anderson Irzal
Published: November 2019

Abstrak. Tujuan penelitian ini adalah untuk mengetahui implementasi nilai toleransi dalam pembelajaran tematik kelas V SDN No 112/1 Perumnas Muara Bulian semester ganjil tahun ajaran 2015/2016. Jenis Penelitian Deskriptif Kualitatif. Teknik Pengumpulan data observasi dan wawancara. Hasil penelitian yaitu implementasi nilai toleransi dalam pembelajaran tematik dikelas V SD N 112/ Perumnas telah terlaksana melalui pembiasaan belajar, hal ini dilihat dari enam indikator yang diteliti  oleh peneliti (menghargai pendapat orang lain, tidak memotong pembicaraan orang lain, tidak memaksakan pendapat kepada orang lain, mampu menerima dengan lapang dada jika dirinya salah, mengutarakan pendapat dengan sopan, dan tidak menyinggung orang lain dalam perkataan maupun perbuatan). hanya dua indikator yang sulit terlaksana yaitu siswa memotong pembicaraan selama proses pembelajaran dan siswa memaksakan pendapat kepada orang lain . Namun masih ada yang perlu ditingkatkan dalam penerapan nilai toleransi itu sendiri kepada siswa, agar implementasi nilai toleransi tersebut dapat terlaksana dan berjalan optimal

Kata Kunci : Toleransi, Pembelajaran Tematik
Peran Kepemimpinan Kepala Sekolah Dalam Implementasi Pendidikan Karakter Di Sekolah Dasar
Authors: Salam M
Published: November 2019

Abstrak. Tujuan penelitian ini adalah untuk mengetahui peran kepemimpinan kepala sekolah dalam implementasi pendidikan karakter. Selain itu juga untuk mengetahui faktor pendukung dan faktor penghambat dalam implementasi pendidikan karakter. Penelitian menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif. Teknik pengumpulan data yang digunakan adalah observasi partisipasi pasif, wawancara terpimpin, dan dokumentasi. Analisis data yang digunakan adalah analisis data model Spradley. Berdasarkan hasil penelitian dapat disimpulkan bahwa kepala sekolah menjalankan perannya sebagai leader, tampak dari sikap kepala sekolah yang ramah, bertanggung jawab, mendidik, dan merangkul semua warga sekolahnya. Sebagai manager, kepala sekolah memiliki beberapa strategi dan kepala sekolah melibatkan seluruh warga sekolah bahkan kepala sekolah juga turut melibatkan orang tua siswa. Selanjutnya, sebagai supervisor kepala sekolah secara langsung terjun kelapangan, melakukan mentoring terhadap guru-guru melalui program S.I.G, serta melakukan evaluasi langsung disetiap akhir semester dan dibukukan menjadi laporan tahunan kepala sekolah.

 Kata Kunci : Implementasi, Pendidikan, Karakter
Hubungan Gaya Mengajar Guru Dengan Keaktifan Belajar Siswa Sekolah Dasar
Authors: Emosda E , Putri Eka
Published: November 2019

Abstrak.Tujuan penelitian ini ialah untuk mengetahui hubungan gaya mengajar guru dengan keaktifan belajar siswa Kelas VSD Negeri 51/IVKota Jambi. Jenis penelitian ini merupakan penelitian (korelasional) yaitu “penelitian yang dimaksudkan untuk mengetahui ada tidaknya hubungan antara dua variabel atau lebih atau hubungan antara variabel bebas dan variabel terikat” Penelitian dilaksanakan di kelas Va dan Vb SD Negeri 51/IV Kota Jambi, jalan Raja Yamin Rt 27/08 Kelurahan Selamat Kecamatan Telanaipura Kota jambi. Waktu penelitian direncanakan pada bulan Juni 2015. Berdasarkan hasil penelitian uji dari uji normalitas untuk data gaya mengajar guru Lo (0.0903) < Ltabel (0,1153), sedangkan data keaktifan belajar siswa didapat Lo (0,1014) < Ltabel (0,1153). Uji homogenitas varians yang digunakan adalah Uji F dikatakan homogen apabila F hitung < F tabel, berdasarkan analisis data diperoleh F hitung (2.006) < F tabel (3,15) maka berdasarkan hasil analisis dapat disimpulkan bahwa data bervariansi homogen. Dengan menggunakan rumus (n-2)59-2 = 57 pada α = 0,05, maka dengan dk 2, untuk uji dua pihak t 0,95 = 1,6720 mudah dilihat bahwa 11.15883> 1,6720 maka terdapat hubungan gaya mengajar guru dengan keaktifan belajar siswa kelas V SD N 51/IV Kota Jambi.

 

Kata kunci: Gaya Mengajar Guru, Keaktifan belajar Siswa
Pengembangan Media Konkret Pada Pembelajaran Tema Lingkungan Kelas III Sekolah Dasar
Authors: Destrinelli D , Hayati Dwi Kurnia , Sawinty Endang
Published: November 2019

Tujuan penelitian adalah untuk membuat bahan ajar tematik pada pembelajaran tema lingkungan kelas III Sekolah dasar yang valid dan menarik. Prosedur pengembangan yaitu Analysis, Design, Development, Implementation, dan Evalutation. Teknik  pengumpulan data yaitu angket. Bahan ajar yang telah dibuat kemudian divalidasi oleh validator. Meliputi validasi ahli media, dan validasi pembelajaran. Hasil validasi ahli media diperoleh nilai rata-rata yaitu 71% maka produk ini termasuk dalam kategori “baik” dan layak untuk diujicobakan. Hasil validasi ahli pembelajaran diperoleh nilai rata- rata yaitu 84.3% maka produk ini termasuk dalam kategori “ sangat baik” dan layak untuk diujicobakan. Dari penelitian yang dilakukan dapat disimpulkan bahwa bahan ajar yang digunakan pada pembelajaran tema lingkungan kelas III sekolah dasar dalam  proses pembelajaran digunakan sebagai instrumen penunjang pembelajaran dan memiliki kemenarikkan dalam pembelajaran.
Kontribusi Pendekatan Scientific Dalam Proses Pembelajaran Terhadap Keaktifan Belajar Siswa Sekolah Dasar
Authors: Nelyahardi N , Wahyudin A Romi
Published: November 2019

Abstrak. Tujuan penelian ini adalah untuk mengetahui kontribusi pendekatan scientific terhadap keaktifan belajar siswa sekolah dasar. Jenis penelitian deskriptif kuantitatif. Tempat diadakan penelitian ini adalah SDN No.156/ I Bulian Baru, dengan  alamat di Desa Bulian Baru, Kab. Batanghari, Provinsi Jambi. penelitian ini telah  dilaksanakan pada tanggal 07-28 September tahun ajaran 2016/2017. sampel penelitian adalah seluruh siswa kelas IV  yang berjumlah 27 orang siswa. Instrumen yang digunakan dalam penelitian ini adalah angket. Berdasarkan hasil penelitian dan pembahasan terdapat kontribusi pendekatan scientific dalam pembelajaran terhadap keaktifan belajar siswa diperoleh hasil r hitung = 0,704  dan r table = 0,381. Yang artinya ada kontribusi pendekatan scientific terhadap keaktifan belajar siswa karena t hitung > r tabel (0,704 > 0,381) sehingga memiliki kategori kontribusi yang kuat. Sedangkan untuk uji signifikan diperoleh t hitung  = 2,0595 pada taraf signifikan α = 5%, n = 27, dk = n – 2 = 27 – 2 = 25. Hal  ini berarti t hitung > t tabel Jadi dapat disimpulkan bahwa terdapat kontribusi yang signifikan antara pendekatan scientific dengan keaktifan belajar siswa kelas IV SDN No.156/I Bulian Baru, Batanghari, Jambi.

Kata kunci : pendekatan saintifik, aktifitas pembelajaran
EFEK SALEP EKSTRAK PINANG TERHADAP LEVEL FIBROBLAST DAN KOLAGEN PADA PROSES PENYEMBUHAN LUKA
Authors: Rahman Ave Olivia , Humaryanto Humaryanto
Published: November 2019

ABSTRACT

Background: Some plants, such as betel nuts (Areca catechu), is used as traditional antiseptic. Betel nut mash is applied on ulcus wound.  Fibroblast and collagen are important factor in wound healing.  Research objective : this study is to determine the effect of betel nuts extract on fibroblast and collagen level in full thickness wound healing processs. Methodology: this study used male rats Sprague dawney that randomly divided into 3 groups. Groups I received no treatment, groups II and III received areca catechu extracts with concentration 15% and 30%  respectively. There are 12 rats in each groups. The treatment is given every day without wound’s debridement. Incision were made full thickness with diameter size 1,5 cm, on right back skin was made by lidocain anesthesia subcutaneously. Wound area were measured every days. Termination of rats were done in day 7 and day 16 to histopathology assessment with Haematoxylin-Eosin stain for fibroblast and collagen level by semiqualitative score. Results: level of collagen were higher in group that received extract but level of fibroblast were lower than control group in histopathology of day 7th. Conclusion:  Extract of betel nut increased level of collagen.

Keyword : areca catechu, betel nuts, wound, fibroblast, collagen, histopathology

 

ABSTRAK

Latar belakang :  Beberapa tanaman digunakan sebagai antiseptik luka, salah satunya biji pinang  untuk penyembuhan luka ulkus. Fibroblast dan kolagen merupakan salah satu faktor penting dalam penyembuhan luka. Tujuan : Penelitian ini bertujuan mengetahui efek ekstrak biji pinang terhadap level fibroblast dan kolagen pada proses penyembuhan luka full thickness  Metode : Penelitian ini menggunakan tikus galur Sprague dawney jantan berusia 2-3 bulan dan telah mendapatkan persetujuan etik. Setelah aklimatisasi, tikus dibagi secara acak masing-masing 12 ekor dalam 3 kelompok, yaitu kelompok I tanpa perlakuan, kelompok II diberikan salep ekstrak biji pinang 15%, kelompok III diberikan salep ekstrak biji pinang 30%. Luka full thickness dibuat dengan diameter 1,5 cm di daerah punggung belakang bagian kanan dengan anestesi lidokain subkutan. Perlakuan dilakukan setiap hari tanpa debridemen luka. Luas luka diukur  setiap hari. Terminasi dilakukan pada hari ke 7 dan 16 untuk pemeriksaan histopatologi jaringan luka dengan pengecatan Haematoxylin-Eosin. Skoring secara semikualitatif untuk menilai fibroblast dan kolagen. Hasil : Pada kelompok ekstrak pinang terdapat peningkatan level kolagen, akan tetapi tidak terjadi peningkatan level fibroblast pada hasil histopatologi luka kulit hari ke-7.  Kesimpulan :  terjadi peningkatan level kolagen pada pemberian ekstrak biji pinang.

Kata kunci : biji pinang, luka, histopatologi, fibroblast, kolagen
Pengaruh Pemberian Kurma Muda (Phoenix dactylifera) Terhadap Kadar Esterogen Pada Tikus Putih (Rattus norvegicus)
Authors: Fitri Amelia Dwi , Herlambang Herlambang , Herlambang Herlambang
Published: November 2019

ABSTRACT

Background: Infertility may give an impact on psychosocial. In Indonesia, the habit of consuming young dates is often done by couples to increase fertility. Estrogen is one of the factors that play a role in the menstrual cycle. The lack of scientific evidence of young dates consumption effects on female reproduction has led to this study.

Method: This study used an experimental design using 28 female Sprague-Dawley rats which were randomly divided into 4 groups. Group I to III was given young dates in successive doses: 17 mg, 34 mg, 68 mg per 200 grams of body weight and group IV was given distilled water (aqua dest). The treatment was carried out for 28 days. Estradiol levels were examined before treatment during the proestrus phase which was known from microscopic examination of rat vaginal swabs. The treatment begins during the proestrus phase.

Result: There is an increase of mean baseline and post-treatment estradiol levels 24.48 and 25.03 respectively

Conclusion: There is no significant increase of B-Estradiol levels of female Spague-Dawley rat uterus as the effect of giving young dates (Phoenix Dactylifera).

Keywords: Dates, Β-Estrodiol, Rats

 

ABSTRAK

Latar Belakang : Infertilitas dapat memberikan dampak psikososial. Di Indonesia, Kebiasaan mengkonsumsi kurma muda sering dilakukan oleh pasangan untuk meningkatkan kesuburan. Hormon estrogen merupakan salah satu faktor yang berperan dalam siklus menstruasi. Belum adanya bukti ilmiah efek konsumsi buah kurma muda terhadap reproduksi wanita mendorong dilakukannya studi ini.

Metode: Penelitian ini menggunakan desain ekperimental menggunakan tikus Sprague dawney betina sebanyak 28 ekor yang dibagi secara acak menjadi 4 kelompok. Kelompok I-III diberikan kurma muda dosis berturut -turut 17 mg, 34 mg, 68 mg per 200 gram BB dan kelompok IV diberikan aquadest. Perlakuan dilakukan selama 28 hari. Kadar hormon estradiol diperiksa sebelum perlakuan saat fase proestrus yang diketahui dari pemeriksaan mikroskopis swab vagina tikus dan sebelum terminasi. Perlakuan dimulai saat fase proestrus. Terminasi dilakukan pada hari ke-29 saat fase proestrus.

Hasil: Terdapat peningkatan rerata kadar estradiol baseline dan paska perlakuan adalah 24,48 dan 25,03.

Kesimpulan: Tidak terdapat peningkatan yang signifikan kadar B-Estradiol pada uterus tikus Spague Dawney terhadap efek pemberian buah kurma muda (Phoenix Dactylifera).

Kata kunci: Kurma, Β-Estrodiol, Tikus
Pengaruh Terapi Gizi Klinik Intensif Terhadap Penurunan Berat Badan, Komposisi Tubuh, dan Profil Lipid pada Remaja Overweight dan Obesitas
Authors: Halim Rita , Suzan Raihanah , Karolina Maria Estela
Published: November 2019

ABSTRACT

Background: Current nutritional status issues are no longer focused on malnutrition, but also on excess nutrition that can occur in all age groups, especially vulnerable to occur at a young age. Objective: to assess the effect of intensive clinical nutrition therapy on weight loss, body composition and lipid profile in overweight and obese adolescents. Method: This study was a case control study and was carried out during the months of August - September 2018, where the sample of the study would be antopometric examination, body composition and lipid profile before and after the intervention. Results: there was no significant difference in the effect of intervention between intensive nutrition therapy compared to only nutrition counseling in weight loss, body composition, and lipid profile. Conclusion: Nutritional intervention in the form of intensive nutrition therapy and counseling conducted in this study had significant results in weight loss, lipid profile and body composition in overweight and obese adolescents, although no significant effect was found on the two interventions.

Keywords: Nutritional intervention, weight loss, body compotition, lipid profile, overweight, obesitas

 

ABSTRAK

Latar belakang: Permasalahan status gizi saat ini bukan lagi hanya terpusat pada kekurangan gizi saja, namun juga pada kelebihan gizi yang dapat terjadi pada semua golongan usia, terutama rentan terjadi pada usia muda. Tujuan: menilai pengaruh terapi gizi klinik intensif terhadap penurunan berat badan, komposisi tubuh dan profil lipid pada remaja overweight dan obesitas. Metode: Penelitian ini merupakan penelitian case control dan dilakukan selama bulan Agustus – September 2018, dimana sampel penelitian akan dilakukan pemeriksaan antopometri, komposisi tubuh dan profil lipid sebelum dan sesudah intervensi. Hasil: tidak terdapat perbedaan pengaruh intervensi secara bermakna antara terapi gizi intensif dibandingkan dengan hanya penyuluhan gizi saja dalam menurunkan berat badan, komposisi tubuh, dan profil lipid. Kesimpulan : intervensi gizi berupa terapi gizi intensif dan penyuluhan yang dilakukan pada penelitian ini memiliki hasil yang bermakna terhadap penurunan berat badan, profil lipid dan komposisi tubuh pada remaja overweight dan obesitas walaupun tidak ditemukan perbedaan yang bermakna dari kedua intervensi tersebut.

Kata Kunci: intervensi gizi, penurunan berat badan, komposisi tubuh, profil lipid, overweight, obesitas
Allium panormitisi (Amaryllidaceae), a new autumn-flowering species from Symi Island, SE Aegean, Greece
Authors: Galanos Christos , Tzanoudakis Dimitrios
Published: November 2019

Allium panormitisi, from the island of Symi (SE Aegean, Greece), is described
as a species new to science. It is an autumn-flowering species of Allium
section Codonoprasum (Amaryllidaceae) and is classified as endangered (EN)
according to IUCN criteria. Its morphology, karyology and conservation
status are presented and discussed, in addition to its taxonomic
relationships to other autumnal species of A. sect. Codonoprasum distributed
in the E Mediterranean area.
What we talk about when we talk about family?: Concept in context
Authors: Tomanovic Smiljka
Published: November 2019

The aim of the paper is to point at the sources of ideologization of concept
of family through presenting its definition and use in modern social, mainly
sociological, thought in XIX and XX century. The analysis has been done
through contextualization - interpretation of family concept definition
within frameworks of various sociological theories that are embedded within
socio-historical contexts of their emergence. The first part of the paper
deals with main obstacles for conceptualization and exploration of family
life. Analysis of sociological theories showed that both definition of
family and the attitude towards modern family are in function of central
theoretical proposition of the approach, whether it is set as social system
integration or emancipation of an individual. Sociological studies are also
burdened with normativism, since scholars view modern family as an
ideological construct of ?success story?, both from the standpoint of its
apology or criticism, therefore neglecting reality of family life in its
variety. In the concluding part, I raise the questions of possibility and a
mode of comprehending and exploring particularly contemporary family without
a burden of its ideologization.
The Valuation of Discontinued Operations and Its Effect on Classification Shifting
Authors: Kaplan Steven E. , Kenchington David G. , Wenzel Brian S.
Published: November 2019

Research documents that firms shift operating expenses into income-decreasing, but not income-increasing, discontinued operations. We argue that valuation considerations explain this asymmetric result, as acquirers are likely to value the earnings of income-increasing discontinued operations more highly than the earnings of income-decreasing discontinued operations. Using a large sample of hand-collected data, we show that pre-tax earnings and operating expenses are significantly more value-relevant for income-increasing discontinued operations, supporting our economic explanation for why firms do not shift operating expenses into income-increasing discontinued operations. Additional analysis shows that in situations where managers are constrained from shifting operating expenses due to valuation concerns, they shift tax expense (an expense that is less value-relevant) from continuing operations into income-increasing discontinued operations. Overall, we conclude that valuation considerations constrain firms from shifting operating expenses into income-increasing discontinued operations, but do not constrain firms shifting tax expenses.
Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study
Authors: Pettus Jeremy H. , D’Alessio David , Frias Juan P. , Vajda Eric G. , Pipkin James D. , Rosenstock Julio , Williamson Gretchen , Zangmeister Miriam A. , Zhi Lin , Marschke Keith B.
Published: November 2019

OBJECTIVE

Evaluate the safety and efficacy of RVT-1502, a novel oral glucagon receptor antagonist, in subjects with type 2 diabetes inadequately controlled on metformin.

RESEARCH DESIGN AND METHODS

In a phase 2, double-blind, randomized, placebo-controlled study, subjects with type 2 diabetes (n = 166) on a stable dose of metformin were randomized (1:1:1:1) to placebo or RVT-1502 5, 10, or 15 mg once daily for 12 weeks. The primary end point was change from baseline in HbA1c for each dose of RVT-1502 compared with placebo. Secondary end points included change from baseline in fasting plasma glucose (FPG) and safety assessments.

RESULTS

Over 12 weeks, RVT-1502 significantly reduced HbA1c relative to placebo by 0.74%, 0.76%, and 1.05% in the 5-, 10-, and 15-mg groups (P < 0.001), respectively, and FPG decreased by 2.1, 2.2, and 2.6 mmol/L (P < 0.001). The proportions of subjects achieving an HbA1c <7.0% were 19.5%, 39.5%, 39.5%, and 45.0% with placebo and RVT-1502 5, 10, and 15 mg (P ≤ 0.02 vs. placebo). The frequency of hypoglycemia was low, and no episodes were severe. Mild increases in mean aminotransferase levels remaining below the upper limit of normal were observed with RVT-1502 but were reversible and did not appear to be dose related, with no other liver parameter changes. Weight and lipid changes were similar between RVT-1502 and placebo. RVT-1502–associated mild increases in blood pressure were not dose related or consistent across time.

CONCLUSIONS

Glucagon receptor antagonism with RVT-1502 significantly lowers HbA1c and FPG, with a safety profile that supports further clinical development with longer-duration studies (NCT02851849).