bluuebunny/crossref_metadata_2025 huggingface dataset:
Multimodale Echocardiographic Evaluation for Early Detection of Cardiotoxicity Induced by Chemotherapy in Childhood Cancer
Authors: Făgărășan Amalia , Ghiragosian-Rusu Simina-Elena , Toma Daniela , Chincesean Mihaela , Andreea Cerghit-Paler , Gozar Liliana , Sasaran Maria Oana
Published: February 2024

Cardiotoxicity remains one of the leading causes of morbidity and mortality in childhood cancer survivors. This study aimed to evaluate cardiotoxic side effects of chemotherapeutic regimens in a pediatric population, as revealed by assessment of baseline end-of-treatment and in follow-up after 1 year. A prospective study was conducted on 39 children, enrolled over a period of 5 years (2017-2022), diagnosed with leukemia and receiving chemotherapy regimens. A multimodal echocardiographic evaluation was done (two-dimensional echocardiography and M-mode, tissue doppler imaging (TDI) and 2D-speckle tracking (2DST) before the initiation of the cytostatic treatment, at the end of the treatment and 1 year after the treatment. Ultrasound-derived parameter values were compared between evaluations and correlated with cumulative doses of chemotherapeutic agents used. There were no significant differences in mean values for any of the imagistic parameters analyzed. However, a significant correlation was found between E’value percentage variation and cumulative dose of both anthracyclines and antimetabolics administered (p=0.03). Moreover, a significant linear regression correlation was found between alkylating agent dose and global longitudinal strain (GLS)(p<0.01). Non-invasive cardiovascular imaging parameter values did not differ significantly from baseline in our study, but some of them seem to be dependent upon cumulative dose of cytostatic agents used. Further studies on larger populations and involving a longer follow-up period might provide more insight into cardiotoxicity of chemotherapy regimens.
Detection of SARS-CoV-2 in Wastewater Associated with Scientific Stations in Antarctica and Possible Risk for Wildlife
Authors: González-Aravena Marcelo , Galban-Malagon Cristobal , Castro-Nallar Eduardo , Barriga Gonzalo P. , Neira Victor , Krüger Lucas , Adell Aiko D. , Olivares-Pacheco Jorge
Published: February 2024

Before December 2020, Antarctica had remained free of Covid-19 cases. The main concern during the pandemic was the limited health facilities available at Antarctic stations to deal with the disease, as well as the potential impact of SARS-CoV-2 on Antarctic wildlife through reverse zoonosis. In December 2020, 60 cases emerged in Chilean Antarctic stations, disrupting the summer campaign with ongoing isolation needs. The SARS-CoV-2 RNA was detected in the wastewater of several scientific stations. In Antarctica, treated wastewater is discharged directly into the seawater. No studies currently address recovery of infectious virus particles from treated wastewater, but their presence raises the risk of infecting wildlife and initiating new replication cycles. This study highlights the initial virus detection in wastewater from Antarctic stations, identifying viral RNA via RT-qPCR targeting various genomic regions. The virus's RNA was found in effluent from two wastewater plants at Maxwell Bay and O’Higgins Station on King George Island and the Antarctic Peninsula, respectively. This study explores the potential for reverse zoonotic transmission of SARS-CoV-2 from humans to Antarctic wildlife due to the direct release of viral particles into seawater. The implications of such transmission underscore the need for continued vigilance and research.
Impact of Amorphous-to-Crystalline Transition on the Upconversion Luminescence in Er3+-Doped Ga2O3 Thin Films
Authors: Liang Yuanlin , Chen Haisheng , Dong Dianming , Guo Jiaxing , Du Xiaona , Bian Taiyu , Zhang Fan , Wu Zhenping , Zhang Yang
Published: February 2024

Gallium oxide (Ga2O3) is an emerging wide bandgap semiconductor promising a wide range of important applications. However, mass production of high-quality crystalline Ga2O3 still suffers from limitations associated with poor reproducibility and low efficiency. Low-temperature grown amorphous Ga2O3 demonstrates comparable performance with its crystalline counterparts. Lanthanide Er3+-doped Ga2O3 (Ga2O3: Er) possesses great potential for developing light-emitting devices, photodetectors and optical waveguides. The host circumstance can exert a crystal field around the lanthanide dopants and strongly influence their photoluminescence properties. Here we present a systematical study of the impact of amorphous-to-crystalline transition on the upconversion photoluminescence in Ga2O3: Er thin films. Through controlling the growth temperature of Ga2O3: Er films, the upconversion luminescence of as-grown thin films are strongly enhanced over 100 times. Moreover, the variation of photoluminescence reflects the amorphous-to-crystalline transformation of the Ga2O3: Er thin films. These results will aid further design of favorable optoelectronic devices integrated with lanthanide-doped Ga2O3 thin films.
Working Memory and Language Relate to Report of Socioemotional Functioning in Children with Hearing Loss
Authors: White Dorothy A. , Costa Elizabeth Adams , Mellon Nancy , Ouellette Meredith , Ottley Sharlene Wilson
Published: February 2024

Children with hearing loss have been found to have significantly more behavioral and emotional challenges than their typically hearing peers, though these outcomes are variable at the individual level. Working memory deficits have been found to relate to executive functioning and overall emotion regulation, leading to behavior challenges. Language development is essential for development of social relationships and communicating one’s needs - this may lead to distress when children cannot communicate effectively. Based on prior findings in children with hearing loss and their typically hearing peers, working memory and language skills were hypothesized to be related to parent and teacher report of socioemotional functioning. Participants were 35 children with hearing loss (66% female, M = 5.17 years old, SD = ±1.97) whose language, working memory, and socioemotional functioning were evaluated during the course of treatment and educational planning. Bivariate analyses indicated that working memory was related to a number of socioemotional domains (e.g., functional communication, atypicality, withdrawal), as were language scores (e.g., social skills, inattention). The direction of these associations was such that stronger working memory and language skills were related to more regulated socioemotional functioning. A call to action of the current study includes more education with regard to profiles and presentations of children with hearing loss, and an early focus on socioemotional learning to foster the development of regulatory skills.
Duration of Rainfall Fades in GeoSurf Satellite Constellations
Authors: Matricciani Emilio , Riva Carlo Giuseppe
Published: February 2024

We have studied the stochastic processes A and B concerning fade durations due to rain, by simulating attenuation time series A(t) (dB) in the zenith paths of GeoSurf satellite constellations, at sites located in different climatic regions, with the Synthetic Storm Technique. Process B gives the statistics of outages (occurrences), process A gives the statistics of outage duration (fraction of time), for the same rain attenuation threshold A(t)>S. The two processes are not independent, therefore, we have studied the relationship between their probabilities and defined a uniformity index 0<U(S)≤1. U(S) is useful for comparing real cases – fade durations fragmented in many different intervals, with changing S and site – and the limiting case of all fades lasting the same time. As S increases, U(S) increases, approaching 1 at very large thresholds. These results should guide the designers of future GeoSurf satellite constellations to consider the impact of A(t) on the diverse communications services. Process B (occurrences) impacts on non–real time services, such as data delivery, more disturbed by the number of outages rather than by their duration. Process A (fraction of time) impacts on real–time services such as television, video conference etc., more disturbed by the duration of the outage.
A Stiffness Approach for Coupling Structural and Magnetic Models for the Design and Optimization of Radial Flux PM Generators for Sustainable Direct-Drive Wind Turbines
Authors: McDonald Alasdair , Jaen-Sola Pablo
Published: February 2024

The mass of a direct-drive generator is often defined by the requirements for structural stiffness to meet the magnetic stiffness between the rotor and stator surfaces. This paper analyses this magnetic stiffness and estimates the structural stiffness of direct-drive generators for different modes of deflection. The magnetic stiffness modelling is based on an analytical model of the airgap closing forces. The final models are verified using Finite Element analysis and carried out for both permanent magnet and wound rotor generators. It shows that wound rotor machines have higher stiffness requirements than permanent magnet machines. The structural stiffness of the generator rotor and stator are evaluated for different modes by applying spatially-varying forces and finding the associated deflections. Structural stiffnesses for the rotor, stator and bearing are then combined. Finally, the magnetic and structural stiffnesses are combined and a stiffness margin can be found. For the airgap not to close, this combined stiffness must be greater than 0. This method is applied to a relatively stiff and a relatively compliant set of generator structures in a case study in order to find the optimum and more sustainable configuration.
Performance Assessment of Repair and Reinforcement of Concrete Cable-Stayed Bridges in Service Based on Time-Dependent Reliability under Environmental Sustainability Development
Authors: Xiaolin Fan , Dong Fenghui , Wang Jiaqing
Published: February 2024

The reliability of concrete cable-stayed bridge structure is time variant. This is due to strength deterioration and time-variant mechanical and environmental loadings. Demands for keeping concrete cable-stayed bridge structure in functional and reliable states require maintenance interventions. Limited financial resources require optimal maintenance strategies. These strategies have to consider the effects of uncertainties not only on the structural reliability deterioration but also on the maintenance interventions. By analyzing variation of concrete cable-stayed concrete cable-stayed bridge liabilities and benefit expectation through different maintenance programs, on the condition of satisfying the concrete cable-stayed bridge performance, with the maximum expected benefit as the target to discuss repair and reinforcement strategies for the concrete cable-stayed bridges in service. The method takes into account the present performance and future expected benefit, optimizing the performance of the concrete cable-stayed bridge and the expected benefit through determination policies of concrete cable-stayed concrete cable-stayed bridge maintenance program. The proposed method also includes an advanced cost model which takes into account the interaction between costs of maintenance interventions and their effect on reliability. Examples are presented demonstrating the application of the proposed method to a stock of existing deteriorating concrete cable-stayed bridges under various maintenance scenarios.
SARS-CoV-2 Seroepidemiology and Antibody Levels in Children during BA.5 Predominance Period
Authors: Filippatos Filippos , Tatsi Elizabeth-Barbara , Dourdouna Maria-Myrto , Margeli Alexandra , Syriopoulou Vasiliki , Michos Athanasios
Published: February 2024

This is a SARS-CoV-2 seroepidemiological study in pediatric population(0-16 years) during BA.5 Omicron predominance period in Athens metropolitan area. Serum samples were tested for SARS-CoV-2 nucleocapsid antibodies(Abs-N), representing natural infection during three sub-periods of BA.5 predominance: 01/05/2022-31/08/2022(period A), 01/09/2022-31/12/2022(period B) and July 2023(period C) and epidemiological data were collected. Additionally in period C Abs-N seronegative samples were tested for SARS-CoV-2 spike antibodies(Abs-S). A total of 878 children were tested (males:51.3%) with median age(IQR): 108(36-156) months and seropositivity during the 3 subperiods was: A:292/417(70%), B:288/356(80.9%), C:89/105(84.8%), P-value<0.001. SARS-CoV-2 seropositivity increased for from period A to C for 0-1-year (P-value: 0.044), 1-4 years (P-value: 0.028) and 6-12 years children (P-value: 0.003). Children 6-12y had the highest seroposi-tivity rates in all subperiods (A: 77.3%, B: 91.4% and C: 95.8%). A significant correlation of monthly SARS-CoV-2 median antibody titers with monthly seropositivity rates was detected (rs:0.812, P-value:0.008). During period C, an additional 12/105 (11.4%) Abs-S seropositive and Abs-N ser-onegative samples were detected and total seropositivity was estimated at 96.2% (101/105). The increased SARS-CoV-2 seropositivity detected in current seroepidemiology study illustrates a high exposure rate during BA.5 predominance period. These data could guide public health decisions regarding immunization strategies and protection measures.
Assessment the Allelopathic Activity of Various Parts of Platycodon (Platycodon grandiflorus) and Its Mitigation via Activated Carbon
Authors: Bao Long , Zhao Xuemei , Kang Gaowa , Suzuki Kaito , Ismail Tamer , Fujii Yoshiharu , Motoki Satoru
Published: February 2024

Continuous cropping of Platycodon produces problems that significantly impact its yield and quality making it a pressing issue that requires immediate attention. In this study, the sandwich method is employed to evaluate the allelopathic activity of different plant parts (leaves, stems, and roots) of Platycodon. The inhibitory effects of the various Platycodon plant parts were quantified based on their effects on lettuce seedlings growth by Sandwich method, with the following average inhibition percentages at 1 mg/ml (agar) of : leaves (79.4%, 61.8%), stems (58.0%, 45.7%), and roots (53.4%, 49.3%) for lettuce radicals and hypocotyls, respectively. At a concentration of 5 mg/ml, the inhibitory effects were as follow: leaves (91.9%, 72.2%), stems (79.5%, 60.3%), and roots (71.4%, 65.2%). Also, by employing the Plant Box method, it was determined that Platycodon root exudation. The growth inhibition rates of lettuce seedling roots and hypocotyls were 45.5% and 18.9%, respectively. The effect of activated carbon on the adsorption of allelopathic substances was investigated, and the results of the sandwich method with a concentration of 1 mg/ml showed the following growth inhibitory effects on lettuce seedlings and hypocotyls: roots (27.8%, 25.7%), leaves (13.3%, 25.7%), and stem (9.07%, 13.6%). The Plant Box method revealed average rates of inhibition of -16.7% and -4.70% on the growth of lettuce seedlings and hypocotyls, respectively. The results of this study demonstrated that activated carbon has a mitigating effect on the allelopathic inhibition associated with the different plant parts and root exudation of Platycodon, thus may provide a potential solution for overcoming obstacles associated with continuous cropping of Platycodon.
Prenatal and Postnatal Disparities in Very Preterm Infants in a Study of Infections between 2018–2023 in the Southeastern US
Authors: Dail Robin B , Everhart Kayla C. , Iskersky Victor , Chang Weili , Fisher Kimberley , Warren Karen , Steflik Heidi J
Published: February 2024

Abstract: Background: The birthrate of Black preterm (BPT) infant is 65% higher than White preterm (WPT) infants with BPT mortality 2.3 times higher. The incidence of culture positive sepsis is as high as 41% in preterms. This study aimed to examine infections and mortality in BPTs and WPTs. Methods: We enrolled 362 preterms born < 32 weeks gestational age (GA) between 2019-2023 in 5 neonatal intensive care unit (NICU)s to study onset of infections, and dispositions; RedCap data were analyzed for descriptive statistics. Results: 226 BPTs (63.5%) and 107 WPTs (30.8%) enrolled, with 29 other than White or Black, 50.5% female, mean GA of 27.67 weeks and 986.74 grams birthweight. Of 426 suspected infections evaluated in enrolled infants, there were 7 infants with early onset sepsis (EOS) and 39 infants with late onset sepsis (LOS). The incidence of EOS was 1.9% overall, 2.2% in BPTs vs 0.9% in WPTs. LOS incidence was 10.8% overall, 11.9% in BPTs and 9.3% in WPTs. Both BPT and WPT infants had ~ 8% gram-positive LOS events and 3% gram-negative LOS events; however, 82% of all gram-negative LOS episodes occurred in BPTs. There were 27 urinary tract infections and 78% were in BPTs. Two cerebral spinal fluid cultures were positive in BPTs. Necrotizing enterocolitis was diagnosed in 5.8% of the sample, with an incidence of 6.1% in BPTs versus 4.7% in WPTs. Death occurred in 6.0% of the enrolled infants with the rate of death being slightly higher in BPTs (7.0%) versus WPTs (5.6%). Conclusions: BPTs had a higher rate of positive cultures, double the gram-negative infections, a much higher rate of urinary tract infec-tions and a higher rate of mortality than their WPT counterparts. This study emphasizes higher risk of morbidity and mortality for BPTs.
Effect of Infill Parameters and Nano-Reinforcement on Compression Performance of 3D Printed Polylactic Acid
Authors: Farias Dorivane , Oliveira Dhonata Caldas , Quaresma Luciano , Sousa Mário , Pinheiro Miriane Alexandrino , Angélica Rômulo S. , Da Paz Simone Patrícia Aranha , Dos Reis Marcos Allan Leite
Published: February 2024

With the advancement of Additive Manufacturing and its applications in various industrial segments, it becomes increasingly important to investigate the processability parameters associated with nano-reinforcement. This study examines the influence of infill parameters, such as patterns (hexagonal, triangular and concentric), shape (solid and honeycomb) and concentrations by mass of Carbon Nanotubes (CNTs) at 1.0 wt% and 2.0 wt% on the mechanical compression properties of the 3D printed material. In this sense, nanocomposites based on Polylactic Acid (PLA) matrix nano-reinforced by CNTs were characterized using the Scanning Electron Microscopy -SEM, X-ray Diffraction, Raman Spectroscopy techniques and mechanical analysis. The mechanical properties of both the matrix and the nanocomposites were determined through mechanical compression tests, in accordance with [1]. SEM revealed compacted regions, voids, and detachment in the structures. XRD characterization indicated PLA predominantly amorphous nature, while CNTs exhibited characteristic diffractions of carbon nanotubes. Raman characterization showcased bands and characteristic vibrations of CNTs and PLA, nanocomposites' vibrational modes combine those of CNTs and PLA. Mechanical compression analysis indicates a direct influence of infill pattern, shape, and nano-reinforcement. The triangle pattern outperformed other patterns, exhibiting a 15.03% increase compared to concentric and 8.8% compared to hexagon infill. In nanocomposites, all showed higher compressive strength than the matrix. For PLA/1.0%CNTs, strength was 16.8%, and for PLA/2.0%CNTs, it reached 39.2%. In honeycomb shapes with infill variations, the triangular pattern excelled with a 0.97% increase over concentric and 6.12% over hexagon patterns. Honeycomb results indicate a 59.6% increase for (PLA/1.0%CNTs) and a 0.48% increase for (PLA/2.0%CNTs) compared to the matrix. This study highlights 3D printing parameters, emphasizing the effectiveness of the triangular pattern and the enhanced strength with the addition of CNTs, providing insights to enhance products manufactured through Additive Manufacturing.
Research Progress on the Application of Crop Yield Calculation based on Image Analysis Technology
Authors: Yu Feng , Wang Ming , Xiao Jun , Zhang Qian , Zhang Jinmeng , Liu Xin , Ping Yang , Luan Rupeng
Published: February 2024

Yield calculation is an important link in modern precision agriculture, which is an effective means to improve breeding efficiency, and adjust planting and marketing plans. With the continuous progress of artificial intelligence and sensing technology, yield calculation schemes based on image processing technology have many advantages such as high accuracy, low cost, and non-destructive calculation, and have been favored by a large number of researchers. This article reviews the research progress of crop yield calculation based on remote sensing images and visible light images, describes the technical characteristics and applicable objects of different schemes, and focuses on detailed explanations of data acquisition, independent variable screening, algorithm selection and optimization. Common issues are also discussed and summarized. Finally, solutions are proposed for the main problems that have arisen so far, and future research directions are predicted, with the aim of achieving more progress and wider popularization of yield calculation solutions based on image technology.
Creating Synthetic Graphs for the Traveling Salesman Problem
Authors: Avramenko Aleksandr Dmitrievich , Sudakov Vladimir Anatolievich
Published: February 2024

The study is dedicated to the pressing issue of solving the Traveling Salesman Problem (TSP). The paper focuses on the development of neural network approaches to solving this problem, emphasizing the need for training models on a sufficient volume of data, which is not feasible to obtain in a reasonable time under current conditions. Therefore, the authors propose an algorithm for generating a random graph with a known shortest path or a path close to the optimal one. As a result of the study, an algorithm for augmenting adjacency matrices for the TSP with a known route was created.
Surgical correction of cesarean scar defect. Is there room for operative hysteroscopy?
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Davydov A.I. , Bakhtiyarov K.R. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Pashkov V.M. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lebedev V.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chilova R.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gasratova A.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Sokolenova I.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

Among the complications of abdominal delivery, a special place is occupied by a defect (failure) of the scar on the uterus after a cesarean section, a cesarean scar defect (CSD). The main problem of CSD is the risk of uterine rupture during subsequent pregnancies and births. However, CSD can cause several gynecological and obstetric disorders, including abnormal uterine bleeding, dysmenorrhea, infertility, and ectopic pregnancy. In addition to abdominal or vaginal metroplasty, treatment options for CSD include operative hysteroscopy, which has been emphasized in recent years. However, as our studies have shown, its potential to correct CSD is strictly limited and concerns primarily the management of gynecological symptoms in women not planning pregnancy. As an independent method, it can be used only in patients with deep but not wide isthmocele. The thickness of the residual myometrium in such cases is not of fundamental importance. Key words: cesarean scar defect, metroplasty, operative hysteroscopy, indications, conditions
Eclampsia. A current picture
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Timokhina E.V. , Gutsu V.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ignatko I.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Muravina E.L. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Popova Yu.M. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Grigoryan I.S. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

Hypertensive disorders consistently occupy one of the leading causes of maternal mortality. An important role in the diagnosis of eclampsia is given to MRI (magnetic resonance imaging) of the brain, which allows to identify a pathognomonic symptom of eclampsia, posterior reversible encephalopathy syndrome (PRES). Patients and methods. Six clinical cases of patients with eclampsia were retrospectively analyzed. Results. The result of the first screening showed a low risk of pre-eclampsia in 83.3% of patients, and only 16.7% were at risk. All patients developed the eclamptic episode in the third trimester of pregnancy, and they all had elevated diastolic blood pressure (above 110 mm Hg). In 66.7% of patients, systolic blood pressure was within the range of 180–200 mm Hg. There were no disorders of liver function and coagulation system, and platelet levels were within the normal range. According to the brain MRI, all patients were diagnosed with PRES without signs of cerebral circulation disorders. Conclusion. This study demonstrates that the causes and pathogenesis of eclampsia are still unknown. Perhaps we are talking about a new manifestation of the disease, or maybe the causes lie in the pathogenesis, which is not fully understood. Key words: hypertensive disorders of pregnancy, pre-eclampsia, posterior reversible encephalopathy syndrome, eclampsia, PRES
Low birth weight as a risk factor for early vascular aging
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Podzolkov V.I. , Podzolkova N.M. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Bragina A.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Skvortsova M.Yu. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Druzhinina N.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Gerasimov A.N. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shikhmagomedov R.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Portnyagina M.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lezhenikova A.I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

Low birth weight is associated with an increased risk of cardiovascular disease in adulthood. Objective. To study the relation between birth weight and a marker of arterial stiffness, the ankle-brachial index (ABI), in young healthy individuals to predict cardiovascular disease risks in adulthood. Patients and methods. The study included 265 patients (student volunteers) aged 18 to 30 years (median: 21 [20, 21] years). ABI was determined using the MESI ABPI MD device (2019, Slovenia). Results. Two groups of patients were identified: group 1 comprised individuals with birth weight <2500 g (n = 36, 13.6%), group 2 – those with birth weight ≥2500 g (n = 229, 86.4%). The median ABI in the low-birth-weight group (0.84 [0.79; 0.87]) was lower compared with group 2 (1.09 [0.99; 1.17], р < 0.05), indicating higher arterial stiffness in group 1. According to the results of multivariate regression analysis, smoking (Beta = -0.21, Std.Err. of Beta = 0.02, р = 0.00001) and birth weight (Beta = 0.01, Std.Err. of Beta = 0.0001, р = 0.00000) had a significant effect on the level of ABI. The ROC curve analysis showed that a birth weight of less than 2450 g predicted the risk of increased arterial stiffness (ABI <0.9) (AUC: 91.6 ± 2.1%). The group of patients with birth weight <2450 g was 5.3 times more likely to develop increased arterial stiffness (95% CI: 3.55–7.14; р < 0.0001). Conclusion. Children born with low birth weight (<2450 g) should be considered as a risk group for early vascular aging, which requires an interdisciplinary approach to the management of such patients by different medical specialties: obstetricians, pediatricians, therapists, and cardiologists. Key words: birth weight, low birth weight, ankle-brachial index, arterial stiffness, early vascular aging
Study of the relation between serum omentin-1 levels and insulin resistance in gestational diabetes mellitus
Authors:   Ain Shams University, Egypt, Ibrahim R.H. , Shelbaya S.A. ,   Ain Shams University, Egypt, Elhalawany S.H. ,   Ain Shams University, Egypt, Yones E.I. ,   Ain Shams University, Egypt, Mansour H.Kh. ,   Ain Shams University, Egypt
Published: February 2024

Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable degree that begins or is first identified during pregnancy. Pregnant women with GDM have an increased risk of adverse metabolic outcomes. It is also associated with a higher likelihood of developing obesity and type 2 diabetes mellitus (T2DM) in a mother and her child. Omentin-1, a novel anti-inflammatory adipokine, is recognized as a main visceral secretory adipokine that may play a role in the context of both glucose homeostasis and insulin resistance (IR). Objective. To evaluate serum omentin-1 levels in GDM and its relationship with glycemic control, IR, and metabolic parameters. Patients and methods. This study included 75 patients who were divided into three groups: group I – 25 pregnant women with GDM diagnosed according to the WHO-2013 criteria, group II – 25 pregnant women with normal glucose tolerance, group III (control) – 25 healthy non-pregnant women. Fasting plasma glucose (FPG) levels, fasting plasma insulin (FPI) levels, fasting lipid profile, omentin-1, and HOMA-IR were measured in all patients, and a 2-hour 75-g oral glucose tolerance test (OGTT) was performed. Results. Between the groups of patients with and without IR, there was a statistically significant difference regarding serum omentin-1 levels, FPG, FPI, HOMA-IR, triglyceride (TG) levels, total cholesterol levels, as well as high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels (p < 0.01). Serum omentin-1 levels had a negative association with FPI and HOMA-IR in all study groups. In addition, there was a strong negative correlation between serum omentin-1 and glycemic control, total cholesterol, TG, and LDL (p < 0.01) and a strong positive correlation between omentin-1 and HDL (p < 0.01) in all study groups. Conclusion. There was a strong negative correlation between omentin-1 and FPI levels, HOMA-IR, glycemic control, total cholesterol, TG, and LDL in all study groups. Moreover, serum omentin-1 levels were positively correlated with HDL. This suggests that omentin-1 has an essential role in IR during pregnancy. Key words: gestational diabetes mellitus, insulin resistance, omentin-1
Large uterine leiomyoma mimicking an ovarian tumor in a 16-year-old girl
Authors:   Morozov Children’s City Clinical Hospital, Moscow, Russian Federation, Gegraeva D.A. , Korotkova S.A. ,   Morozov Children’s City Clinical Hospital, Moscow, Russian Federation, Khabarova M.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

Uterine leiomyoma (UL) is the most common benign uterine tumor in adult women, but it is extremely rare in adolescence. This article presents a clinical case of a 16-year-old patient diagnosed with a solid ovarian tumor at the pre-hospital stage. The use of contrast-enhanced magnetic resonance imaging allowed to identify a large type 5 UL (90 × 120 × 87 mm), which was confirmed by surgery (laparoscopic myomectomy) and histological examination. A literature review of 19 publications on this problem was also performed and it was found that the youngest age of UL detection was 12 years. Conclusion. Uterine leiomyoma in adolescents is an extremely rare pathology that requires differential diagnosis with ovarian tumors and leiomyosarcoma. Key words: uterine leiomyoma, adolescents, myomectomy, leiomyosarcoma
Leukocytosis and NETosis as markers of poor prognosis in gynecologic oncology patients
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Slukhanchuk E.V. , Bitsadze V.O. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Solopova A.G. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Khizroeva D.Kh. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shcherbakov D.V. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Yagubova F.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Ay С. ,   Medical University of Vienna, Vienna, Austria, Elalami I. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Degtyareva N.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Aslanova Z.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Shkoda A.S. ,   L.A.Vorokhobov City Clinical Hospital No 67, Moscow, Russian Federation, Makatsaria A.D. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: February 2024

The association between leukocytosis and poor disease prognosis has been reported in several types of cancer. However, to date, the potential mechanism of this predictive model has not been presented. Objective. To examine the correlation between the level of NETosis markers and white blood cell (WBC) count in the blood plasma of gynecologic oncology patients before treatment and the role of these indicators in predicting the course of disease. Patients and methods. This retrospective single-center non-randomized study included 212 patients hospitalized for surgical treatment and chemotherapy between 2016 and 2020: 58 with ovarian cancer, 44 with cervical cancer, 56 with breast cancer, and 54 with uterine cancer. Upon hospitalization, all patients had their WBC counts and other blood counts determined and recorded in a unified database. NETosis markers (citH3 and MPO:Ag concentrations) were determined in patients’ frozen plasma samples. Results. The WBC count of >7·109/L before treatment was noted in patients with later stages of disease according to the TNM (tumor–node–metastasis) staging system. Patients with higher WBC counts had significantly higher MPO:Ag concentrations. The overall survival and progression-free survival rates were significantly worse in patients with WBC >7·109/L and elevated concentrations of NETosis markers before treatment. Conclusion. The results obtained indicate that preoperative leukocytosis is associated with NETosis activation and is observed in patients with advanced stages of disease and poor prognosis. Key words: white blood cells, neutrophil extracellular traps, leukocytosis, NETosis, myeloperoxidase, citrullinated histone
La asistencia a los pobres en la ciudad de Córdoba durante los siglos bajomedievales: su localización geográfica
Authors: Escobar Camacho José Manuel
Published: February 2024

La pobreza en la Sociedad Medieval Tardía Occidental encontró muchas responsabilidades diferentes a lo largo de dicho período histórico. Una de ellas fueron, sin duda, las cofradías que, a través de los hospitales, se convirtieron en agentes muy importantes en la asistencia a los pobres.
Aljibes Hispano-Musulmanes de la provincia de Córdoba
Authors: Córdoba De La LLAVE Ricardo , Rider Porras Faustino
Published: February 2024

Este proyecto tiene como objetivo el estudio arqueológico de un conjunto de embalses hispano-musulmanes asociados a diversas fortalezas y yacimientos arqueológicos de la provincia de Córdoba. Estos depósitos de agua, cámaras subterráneas o parcialmente ahuecadas en el suelo, se encontraban entre las construcciones hidráulicas más utilizadas durante la Edad Media, ya que permitían la captación y almacenamiento del agua de lluvia y su conservación en buenas condiciones para el consumo humano. Los estudiados en nuestra provincia pueden dividirse en dos grupos, el primero de los cuales está formado por un número limitado de depósitos muy grandes, con varias cámaras interiores separadas por arcos y columnas, unidas en espacios cubiertos por bóvedas de cañón, bóvedas de crucero o cúpulas de caracol; el segundo grupo, al que pertenece la mayoría, está formado por depósitos de agua de forma rectangular y de dimensiones reducidas, cubiertos por bóvedas de cañón, y diseñados para satisfacer las necesidades de pequeños grupos de personas.
El desabastecimiento de trigo en Toledo en el siglo XV
Authors: Izquierdo Benito Ricardo
Published: February 2024

El desabastecimiento de trigo en Toledo en el siglo XV
Traductologica Muzarabica, notas a propósito de un fragmento del Codex Arabicus Monachensis Aumer 238.
Authors: Monferrer Sala Juan Pedro
Published: February 2024

Análisis de un fragmento lucano de la “versión occidental” de los Evangelios contenidos en el Codex Arabicus Monachensis Aumer 238, pres¬tando especial atención al origen de la misma e indicando algunos aspectos de interés para ulteriores investigaciones.
La extinción de un linaje señorial en el siglo XIV. La primitiva Casa de Aguilar.
Authors: Cabrera Emilio
Published: February 2024

La primitiva Casa de Aguilar es un ejemplo antológico de un viejo linaje castellano que, como tantos otros, se extingue, por razones biológicas, en la primera mitad del siglo XIV. En este caso concreto, la razón principal de su desaparición es la falta de herederos legítimos, unida a la fatalidad que representa la muerte prematura de algunos de sus componentes en la guerra de frontera. Por otra parte, las vicisitudes que experimenta el señorío de Aguilar a lo largo de los decenios centrales del siglo XIV, una vez extinguida la primera Casa de Aguilar, ejemplifican muy bien algunas de las principales razones que explican la renovación nobiliaria que se produce en el reino de Castilla durante el siglo citado.
Recetas medievales para el vidriado de la cerámica.
Authors: Córdoba de la Llave Ricardo
Published: February 2024

El presente trabajo está dedicado al análisis de las técnicas para el vidriado de la cerámica que aparecen documentadas en diversos tratados y recetarios de época medieval. Se trata de textos procedentes, en su mayor parte, de la Península Italiana, que incluyen recetas dedicadas al vidriado de la cerámica al plomo y al estaño, con particular referencia a la realización de la loza dorada. El estudio comenta los textos donde dichas recetas se insertan, las técnicas de trabajo que mencionan y concluye con un apéndice documental en el que se incluye la traducción al castellano de las recetas estudiadas.
La presencia femenina en los Castillos a la luz de la documentación catalana medieval.
Authors: Vynioles Teresa
Published: February 2024

En la sociedad feudal, dirigida por hombres, parece que el papel de las mujeres sea muy reducido. Ciertamente no era así. Ellas eran la clave del mantenimiento de la sociedad feudal y caballeresca; velaban por el bienestar espiritual y material del castillo y de sus habitantes. La señora o la, esposa del señor, tenía la responsabilidad del linaje y a menudo administraba, gobernaba y custodiaba el castillo, tanto en tiempos de paz como de guerra. En este artículo nos acercamos, con ejemplos documentales, a las castellanas y a las señoras eminentes, en una sociedad feudalizada. Estudiamos el papel de las señoras de los castillos como amas de casa, madres y esposas de guerreros, su relación con las armas y con la rueca.
On the Trail of Lost Ingredients
Authors: Broecke Lara Abigail
Published: February 2024

This paper addresses the question of translation as research. Using examples from Cennino Cennini’s Libro dell’arte  and the 15th century Bolognese Manuscript, written in Italian and Latin, the author uses case studies to exemplify the use of secondary literature, dictionaries and comparative evidence from within the manuscript itself for the identification of materials. The author concludes that translation imposes a very strict discipline, which constrains the translator to push lexical research to its limits.Este documento aborda la cuestión de la traducción como investigación. Utilizando ejemplos del Libro dell'arte de Cennino Cennini y el manuscrito boloñés del siglo XV, escritos en italiano y latín, el autor utiliza estudios de caso para ejemplificar el uso de literatura secundaria, diccionarios y evidencia comparativa del interior del propio manuscrito para la identificación de materiales. El autor concluye que la traducción impone una disciplina muy estricta, que obliga al traductor a llevar la investigación léxica a sus límites.
Cancel Culture: Mempromosikan Keadilan ataukah Pembungkaman Kebebasan Berpendapat?
Authors: Rianto Puji , Sulkhan Khumaid Akhyat , Marantika Nurhana
Published: February 2024

Budaya pembatalan (cancel culture) telah menjadi perhatian di antara ilmuwan sosial dalam lebih satu dekade belakangan, dan telah menimbulkan perdebatan luas di antara ilmuwan sosial. Di Indonesia, fenomena ini telah sering terjadi, tetapi sayangnya belum diinvestigasi secara mendalam. Pengetahuan tentangnya juga masih sangat terbatas. Penelitian ini dilakukan untuk mengkaji fenomena cancel culture dan dampaknya bagi kebebasan berpendapat. Penelitian ini dilakukan secara kualitatif dengan menggunakan netnografi. Hasil penelitian ini menunjukkan bahwa dampak-dampak budaya pembatalan terhadap kebebasan berpendapat sangatlah kontekstual. Dalam kasus Lutfi Agizal, budaya pembatalan mempunyai dampak negatif bagi kebebasan berpendapat. Emosionalitas lebih mengemuka dibandingkan debat rasional. Sebaliknya, dalam kasus Gofar Hilman, jika kekerasan seksual memang terjadi maka budaya pembatalan memberikan kontribusi positif dalam memperjuangkan keadilan. Sebaliknya, jika kekerasan seksual tidak terjadi, maka budaya pembatalan menciptakan pembungkaman dan pengucilan. Cancel culture berdampak negatif terhadap Arawinda Kirana karena tiadanya budaya reflektif di antara para netizen. Oleh karena itu, penelitian ini menyarankan pentingnya melihat kasus demi kasus dalam melihat dampak-dampak budaya pembatalan.
Development of a competitive chemiluminescent assay for quantitative determination of TP53 fusion protein using reagent strips
Authors: wang Linyu , He Zhifang , Li Jianye
Published: February 2024

Recent studies have shown that almost half of all cancers occur due to DNA damage. For the early diagnosis of cancer, a highly sensitized and swift identification for TP53 is needed since the corresponding TP53 protein is effectively recognized as “the guardian of the genome.” To improve the detection sensitivity, numerous analytical methods were previously used for the determination of the TP53 protein, including denaturing high-performance liquid chromatography and enzyme-linked immunosorbent assay (ELISA). Currently, immunochromatographic tests (ICTS) that are simple to use, stable over time, and show low interference are regarded as valuable tools for the quick screening of food and environmental monitoring along with clinical diagnosis. ICTS often have limited sensitivity even if a variety of novel reporters possessing optimum photostability and improved brightness are used as the signal-intensity reporters. Compared with N-(4-aminobutyl)-N-(ethylisoluminol) or luminol, a novel luminescent probe, 2',6'-diMethyl-4'-(N-succiniMidyloxycarbonyl) phenyl-10-sulfopropylacridiniuM-9-carboxylate (NSP-DMAE-NHS) has achieved a much higher efficiency, improvement in the biosensor's performance, and amplification of the signal without causing any damage to the biomolecule in terms of its biochemical activity. In this study, the reagent strip method was initially used to detect TP53 fusion protein by combining the advantages of NSP-DMAE-NHS and immunochromatography. In our experiment, the control and study lines on the strips were immobilized through HRP-conjugated goat anti-rabbit IgG and TP53 antigen, respectively. The optimized concentration of the anti-TP53 antibody-NSP-DMAE-NHS immunoconjugates was then added to the TP53 antigen samples. After, the test strips were inserted and left in the aforementioned buffer solution for an additional 20 minutes. Finally, a lab made luminous measurement device was used to analyze the corresponding control and study lines on the strips. Under optimized conditions, this method was found to be ultrasensitive, with a wide range of linear responses from 0.0008 ng mL-1 to 1 µg mL-1 and a limit of detection of 0.0008 ng mL-1 (0.013 pM). Thus, a novel competitive chemiluminescent assay based on reagent strips was established for the determination of the TP53 fusion proteins. The strategy has potential applications for ultrasensitive detection in the early diagnosis of cancer.
WITHDRAWN: Magnetic Resonance Spectroscopy Displays the Structural and Biochemical Effects of Spinal Manipulative Therapy in Lumbar Discogenic Pain: a case report
Authors: Billham Jessica F , Roland Erika Evans , Gornet Matthew F. , Brinkman Kelly , Schranck Francine , Cox Jim , Kettner Norman W.
Published: February 2024

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Goldbach Conjecture Proof
Authors: Thompson Daniel
Published: February 2024

The Goldbach conjecture was proposed by the German mathematician Christian Goldbach around the year 1742, to another well-known mathematician of that time Leonard Euler. The conjecture has been found to hold for all numbers up to 4 x 10⁸, but remains unproven until now. This paper proves the Goldbach conjecture by showing that elements of the addition of two odd prime numbers produce elements of the resulting even number. The resulting elements from the addition of two odd prime numbers evaluate to an equal amount thus proving that every even number can be expressed as the addition of two odd prime numbers.
MSC: 11-xx.
A Linear Approximate Robust Strategic Asset Allocation with Inflation-Deflation Hedging Demand
Authors: Kusuda Koji , Kikuchi Kentaro
Published: February 2024

This study considers a finite-time consumption-investment problem for investors with homothetic robust utility under the quadratic security market model with stochastic volatilities and inflation rates. This leads to a nonlinear nonhomogeneous partial differential equation for indirect utility. We propose a linear approximation method and derive the approximate optimal robust portfolio decomposed into myopic, intertemporal hedging, and inflation-deflation hedging demands. Furthermore, we propose a method for estimating our quadratic security market model that stabilizes the optimal portfolio estimates. We then apply our estimation method to a two-factor quadratic security market model. Our numerical analysis shows i) the linear approximate optimal portfolio is highly accurate and ii) the market timing effects in the optimal robust allocation are significant and nonlinear, and are mainly due to inflation-deflation hedging demand in addition to myopic demand.
RETRACTED: Performance Enhancement of a PMSM Drive using ANFIS- HCC for Electric Vehicles
Authors: Sangar Brijendra , Singh Madhusudan , Sreej Mini
Published: February 2024

The authors have requested that this preprint be removed from Research Square.