bluuebunny/crossref_metadata_2025 huggingface dataset:
Influences of Heat Rejection from Split A/C Conditioners on Mixed-Mode Buildings: Energy Use and Indoor Air Pollution Exposure Analysis
Authors: Zhong Xuyang , Cai Ming , Wang Zhe , Zhang Zhiang , Zhang Ruijun
Published: January 2024

The heat rejected by outdoor units of split A/C conditioners can impact the ambient outdoor environment of mixed-mode buildings. Nevertheless, how this environmental impact may affect the space-conditioning energy use and indoor air pollution is poorly understood. By coupling EnergyPlus and Fluent, this study examines the effects of outdoor units’ heat rejection on the building surroundings, building cooling load, and indoor PM2.5 exposure of a six-storey mixed-mode building. The building had an open-plan room on each floor, with the outdoor unit positioned below the window. The coupled model was run for a selected day when the building was cooled by air conditioning and natural ventilation. Five mixed-mode cooling strategies were simulated, reflecting different window-opening schedules, airflow rates of outdoor units, and cooling set-points. The results indicate that compared with the always-air-conditioned mode, the mixed-mode operation could significantly mitigate the negative impact of heat rejection on space-cooling energy consumption. Increasing the airflow rate of outdoor units led to a lower increase in demand for space cooling and lower indoor PM2.5 exposure. If one of the six rooms needs to be cooled to a lower temperature than the others; choosing the bottom-floor room helped achieve more energy savings and better indoor air quality.
Optimization of the Energy-Saving Building Envelopes in Regional Climate
Authors: Diao Rongdan , Cao Yinqiu , Sun Linzhu , Xu Chen , Yang Fang
Published: January 2024

For a large number of monolithic buildings in the Wenzhou area, serious cold air infiltration occurs at night due to the poor insulation performance of the enclosure structure. This results in the indoor temperature often falling below the thermal comfort zone, which is compounded by high relative humidity. Various types of energy-efficient buildings, considering different envelope structures (exterior walls, roofs, exterior windows, and shading designs), were constructed, taking into account both structural characteristics and residents’ energy consumption habits. The building environment and energy consumption during the transition period (i.e., summer and winter) were analyzed using the ideal solution similarity ranking preference method (TOPSIS) and the building energy simulation software, EnergyPlus 9.5. This analysis aimed to identify four energy-efficient building models closest to the ideal solution. Comparing the indoor environment parameters and load values of the energy-saving buildings with those of the basic building yielded the following results: the average building load of the energy-saving buildings was 79.48 to 122.00 W lower than that of the basic building. The average temperature difference between the exterior walls of the energy-saving buildings and the interior temperature was 0.6 to 1.45 °C lower than that of the basic building. Similarly, the average temperature difference between the exterior windows and the interior temperature of the energy-saving buildings was 0.56 to 0.98 °C lower than that of the basic building. Additionally, the average temperature difference between the roof and room temperature of the energy-saving buildings was 0.54 to 0.39 °C lower than that of the basic building. Furthermore, the average indoor temperature of the energy-saving buildings was 1.50 to 2.11 °C higher than that of the basic building. In addition, when compared with the basic building, the energy-saving buildings could save 5.66 to 16.39 kg of standard coal and reduce CO2 emissions by 1.60 to 4.47 kg during the transition period. The study of the energy-saving envelope structure combination form in Wenzhou provides a reasonable basis for building an energy-saving envelope structure combination form in the tropical monsoon climate area, which is of great significance for reducing building energy consumption.
Parametric Finite Element Analyses of Demountable Shear Connection in Cold-Formed Steel–Concrete Composite Beams
Authors: Žuvelek Vlaho , Ćurković Ivan , Skejić Davor , Lukačević Ivan
Published: January 2024

It is known that steel–concrete composite systems are very efficient. However, such steel–concrete composite systems can be optimised using cold-formed steel elements and innovative shear connections. In other words, by considering demountability and reusability, the negative impact of the built environment on the whole ecosystem can ultimately be reduced. This paper, therefore, presents a numerical study of an innovative solution for a composite floor system consisting of built-up cold-formed sections and concrete slabs. Through parametric numerical analysis, parameters such as the diameter and quality of bolts, the concrete class, the type of concrete slab, and the steel quality of sections and bolts were varied. The numerical analysis results show that the system with a solid concrete slab had a higher shear resistance and ductility than the system with a concrete slab made with profiled sheeting and showed different failure modes. The presented results form the basis for push-out tests for the proposed shear connection types.
Integrated Interactive Control of Distribution Systems with Multi-Building Microgrids Based on Game Theory
Authors: Lou Wei , Zhu Shenglong , Xu Bin , Zhu Taiyun , Sun Licheng , Wang Ming , Wang Xunting
Published: January 2024

In the transactional processes within a multi-building microgrid system, it is imperative to safeguard stakeholders’ interests and ensure stable, economically efficient operation. Therefore, this paper proposes an integrated interactive control of distribution systems with multi-building microgrids based on game theory. Initially, an interactive framework encompassing superior power grids, distribution network operators, and multi-building microgrids is proposed. This framework establishes a master–slave game model between distribution network operators and multi-building microgrids. Additionally, it introduces the concept of Soft Open Points between building microgrids to enhance system operational safety while also reducing economic costs for distribution network operators. Subsequently, to maintain solution accuracy and optimality, it employs linearization and cone relaxation methods to transform the original model into a mixed-integer second-order cone programming model. Furthermore, it enhances an iterative search method and the price mechanism based on supply and demand ratios. The revised price mechanism serves to boost the participation of building microgrid users in energy regulation, while the iterative search method effectively resolves the equilibrium point of interest among all game participants. Finally, a simulation analysis is conducted on an IEEE-33 test system, and the effectiveness of the proposed strategy is verified by comparing three schemes.
Double-Skin Facades for Thermal Comfort and Energy Efficiency in Mediterranean Climate Buildings: Rehabilitating Vulnerable Neighbourhoods
Authors: López-Escamilla Álvaro , Herrera-Limones Rafael , León-Rodríguez Ángel Luis
Published: January 2024

The ongoing global energy crisis in Europe has intensified energy poverty in vulnerable households, prompting a critical examination of passive retrofit strategies for improving the habitability of obsolete social housing in southern Europe from the 1960s. Given the Mediterranean climate’s characteristics (hot summers and mild winters), these buildings possess low thermal resistance envelopes designed for heat dissipation in summer but contribute to elevated heating demands in colder months. In response to the pressing need for solutions that strike a balance between reducing energy demand and ensuring year-round comfort, this research explores diverse approaches. Drawing insights from built prototypes in Colombia and Hungary and utilizing a validated simulation model in Seville, Spain, this study investigates the feasibility of implementing a double-skin envelope on building facades and assesses the impact of thermal insulation in the air chamber. So, the research specifically aims to find an equilibrium between lowering energy demand and maintaining adequate comfort conditions, concentrating on the renovation of obsolete social housing with envelopes featuring low thermal resistance in the Mediterranean climate. Results indicate that, due to the poor thermal envelope, the influence of thermal insulation on comfort conditions and energy savings outweighs that of the double skin. Consequently, the emphasis of renovation projects for this climate should not solely concentrate on passive cooling strategies but should strive to achieve a positive balance in comfort conditions throughout the year, encompassing both warm and cold months.
Designing for a Flow: Navigating Temporalities in Housing Considerations in Low-Income and Hazard-Prone Caribbean Contexts
Authors: Kuś Aga , Mota Nelson , van Bueren Ellen , Carmona Báez Antonio , Asselbergs Thijs
Published: January 2024

The urgency of addressing housing challenges in low-income areas is increasing due to widening socio-economic inequalities and the worsening impact of natural disasters. Saint Martin, a small Caribbean island, is struggling to provide affordable housing amidst hurricanes, floods, and heat waves. As a result, there has been a rise in self-organized housing units, which are built incrementally and are susceptible to risks. The main challenge is to balance durability, functionality, and esthetic appeal over time. Inspired by St. Martin’s self-organized units, this article explores housing considerations in low-income, hazard-prone contexts by emphasizing their temporalities. Integrating insights from a formative study, including a literature review and ethnographic research, the paper draws on Stewart Brand’s “Layers of Change” and the concept of “Flow”. The study identifies layers within self-organized units corresponding to durability, functionality, and esthetic appeal. It delves into their connection with building activities over time, unveiling the temporalities of housing considerations. This exploration leads to the proposition of “Designing for a Flow” as a novel design approach. Offering practical insights within a concise framework, the study provides nuanced perspectives on mitigating housing challenges in low-income and hazard-prone contexts.
Digitally Enhanced Methods for the Diagnosis and Monitoring of Treatment Responses in Actinic Keratoses: A New Avenue in Personalized Skin Care
Authors: Soare Cristina , Cozma Elena Codruta , Celarel Ana Maria , Rosca Ana Maria , Lupu Mihai , Voiculescu Vlad Mihai
Published: January 2024

Non-melanocytic skin cancers represent an important public health problem due to the increasing incidence and the important local destructive potential. Thus, the early diagnosis and treatment of precancerous lesions (actinic keratoses) is a priority for the dermatologist. In recent years, non-invasive skin imaging methods have seen an important development, moving from simple observational methods used in clinical research, to true diagnostic and treatment methods that make the dermatologist’s life easier. Given the frequency of these precancerous lesions, their location on photo-exposed areas, as well as the long treatment periods, with variable, imprecise end-points, the need to use non-invasive imaging devices is increasingly evident to complete the clinical observations in the diagnosis and treatment of these lesions, with the aim of increasing accuracy and decreasing the adverse effects due to long treatment duration. This is the first review that brings together all skin imaging methods (dermoscopy, reflectance confocal microscopy, ultrasonography, dermoscopy-guided high frequency ultrasonography, and optical coherence tomography) used in the evaluation of actinic keratoses and their response to different treatment regimens.
Association of HOTAIR, MIR155HG, TERC, miR-155, -196a2, and -146a Genes Polymorphisms with Papillary Thyroid Cancer Susceptibility and Prognosis
Authors: Karajovic Jelena , Kovacevic Bozidar , Uzelac Bojana , Stefik Debora , Jovanovic Bojana , Ristic Petar , Cerovic Snezana , Supic Gordana
Published: January 2024

Polymorphisms in long non-coding RNA and microRNA genes may play a significant role in the susceptibility and progression of papillary thyroid carcinoma (PTC). The current study investigates the polymorphisms HOTAIR rs920778, MIR155HG rs1893650, TERC rs10936599, miR-155 rs767649, miR-196a2 rs11614913 and miR-146a rs2910164 in 102 PTC patients and 106 age- and sex-matched controls of the Caucasian Serbian population, using real-time PCR. We observed differences in genotype distributions of the HOTAIR rs920778 (p = 0.016) and MIR155HG rs1893650 (p = 0.0002) polymorphisms between PTC patients and controls. HOTAIR rs920778 was associated with increased PTC susceptibility (adjusted OR = 1.497, p = 0.021), with the TT variant genotype increasing the risk compared to the CC genotype (OR = 2.466, p = 0.012) and C allele carriers (CC + CT) (OR = 1.585, p = 0.006). The HOTAIR rs920778 TT genotype was associated with lymph node metastasis (p = 0.022), tumor recurrence (p = 0.016), and progression-free survival (p = 0.010) compared to C allele carriers. Multivariate Cox regression revealed that ATA risk (HR = 14.210, p = 0.000004) and HOTAIR rs920778 (HR = 2.811, p = 0.010) emerged as independent prognostic factors in PTC. A novel polymorphism, MIR155HG rs1893650, was negatively correlated with susceptibility to PTC, with TC heterozygotes exerting a protective effect (OR = 0.268, p = 0.0001). These results suggest that the polymorphisms HOTAIR rs920778 and MIR155HG rs1893650 could be potential prognostic and risk biomarkers in papillary thyroid carcinomas.
A Systematic Review on Artificial Intelligence Evaluating Metastatic Prostatic Cancer and Lymph Nodes on PSMA PET Scans
Authors: Liu Jianliang , Cundy Thomas P. , Woon Dixon T. S. , Lawrentschuk Nathan
Published: January 2024

Early detection of metastatic prostate cancer (mPCa) is crucial. Whilst the prostate-specific membrane antigen (PSMA) PET scan has high diagnostic accuracy, it suffers from inter-reader variability, and the time-consuming reporting process. This systematic review was registered on PROSPERO (ID CRD42023456044) and aims to evaluate AI’s ability to enhance reporting, diagnostics, and predictive capabilities for mPCa on PSMA PET scans. Inclusion criteria covered studies using AI to evaluate mPCa on PSMA PET, excluding non-PSMA tracers. A search was conducted on Medline, Embase, and Scopus from inception to July 2023. After screening 249 studies, 11 remained eligible for inclusion. Due to the heterogeneity of studies, meta-analysis was precluded. The prediction model risk of bias assessment tool (PROBAST) indicated a low overall risk of bias in ten studies, though only one incorporated clinical parameters (such as age, and Gleason score). AI demonstrated a high accuracy (98%) in identifying lymph node involvement and metastatic disease, albeit with sensitivity variation (62–97%). Advantages included distinguishing bone lesions, estimating tumour burden, predicting treatment response, and automating tasks accurately. In conclusion, AI showcases promising capabilities in enhancing the diagnostic potential of PSMA PET scans for mPCa, addressing current limitations in efficiency and variability.
Using Flavonoid Substitution Status to Predict Anticancer Effects in Human Melanoma Cancers: An In Vitro Study
Authors: Jakimiuk Katarzyna , Szoka Łukasz , Surażyński Arkadiusz , Tomczyk Michał
Published: January 2024

Skin cancers are a dominant type of cancer that impacts millions per year. Cancer is a heterogeneous disease triggered by the irreversible impairment of cellular homeostasis and function. In this study, we investigated the activity of 37 structurally diverse flavonoids to find potentially active substances using two melanoma cell lines: C32 and A375. First, the cytotoxic potential and DNA biosynthesis inhibition of flavonoids were tested to determine the most active compounds in cancer and normal cells. Second, the molecular mechanism of the anticancer activity of flavonoids was elucidated using Western blot and immunofluorescence analyses. Compounds 1, 6, 15, and 37 reduced the viability of A375 and C32 cell lines via the intrinsic and extrinsic pathways of apoptosis, whereas 16 and 17 acted in a higher degree via the inhibition of DNA biosynthesis. In our experiment, we demonstrated the anticancer activity of compound 15 (5,6-dihydroxyflavone) for the first time. The in vitro studies pointed out the importance of the flavonoid core in hydroxyl groups in the search for potential drugs for amelanotic melanoma.
In Vitro Sensitivity of Neuroendocrine Neoplasms to an Armed Oncolytic Measles Vaccine Virus
Authors: Scheicher Nikolai V. , Berchtold Susanne , Beil Julia , Smirnow Irina , Schenk Andrea , Lauer Ulrich M.
Published: January 2024

Neuroendocrine neoplasms represent a heterogenous group of rare tumors whose current therapeutic options show only limited efficacy. Oncolytic viruses exert their mode of action through (onco-)lysis of infected tumor cells and the induction of a systemic antitumoral immune response in a virus-induced inflammatory micromilieu. Here, we investigated the potential of our well-established second-generation suicide-gene armed oncolytic measles vaccine virus (MeV-SCD) in five human NEN cell lines. First, (i) expression of the MeV receptor CD46 and (ii) its correlation with primary infection rates were analyzed. Next, (iii) promising combination partners for MeV-SCD were tested by employing either the prodrug 5-fluorocytosine, which is converted into the chemotherapeutic compound 5-fluorouracil, or the mTOR-inhibitor everolimus. As a result, MeV-SCD was found to kill all NEN tumor cell lines efficiently in a dose-dependent manner. This oncolytic effect was further enhanced by exploiting the prodrug-converting system, which was found to be highly instrumental in overcoming the partial resistance found in a single NEN cell line. Furthermore, viral replication was unaffected by everolimus, which is a basic requirement for combined use in NEN patients. These data suggest that MeV-SCD has profound potential for patients with NEN, thus paving the way for early clinical trials.
Prognostic Thresholds of Mitotic Count and Ki-67 Labeling Index for Recurrence and Survival in Lung Atypical Carcinoids
Authors: Soldath Patrick , Bianchi Daniel , Manfredini Beatrice , Kjaer Andreas , Langer Seppo W. , Knigge Ulrich , Melfi Franca , Filosso Pier Luigi , Petersen René Horsleben
Published: January 2024

Atypical carcinoid (AC) is a rare neuroendocrine neoplasm of the lung, which exhibits a varying malignant potential. In this study, we aimed to identify the prognostic thresholds of the mitotic count and Ki-67 labeling index for recurrence and survival in AC. We retrospectively reviewed 78 patients who had been radically resected for AC and calculated said thresholds using time-dependent receiver operating characteristic curves and the Youden index. We then dichotomized the patients into groups of above or below these thresholds and estimated the cumulative incidences of the groups using the Aalen–Johansen estimator. We compared the groups using univariable and multivariable Fine–Gray subdistribution hazard models. Our findings show that more patients recurred and died from this disease if their mitotic count exceeded three and four mitoses per 2 mm2, respectively, or if their Ki-67 labeling index exceeded 14% and 11%, respectively. Both thresholds independently predicted survival (p < 0.001 and p = 0.015, respectively). These thresholds may serve as a valuable tool for clinicians and researchers in making treatment plans and predicting outcomes for patients with AC.
Metabolic Signature of Warburg Effect in Cancer: An Effective and Obligatory Interplay between Nutrient Transporters and Catabolic/Anabolic Pathways to Promote Tumor Growth
Authors: Mathew Marilyn , Nguyen Nhi , Bhutia Yangzom , Sivaprakasam Sathish , Ganapathy Vadivel
Published: January 2024

Aerobic glycolysis in cancer cells, originally observed by Warburg 100 years ago, which involves the production of lactate as the end product of glucose breakdown even in the presence of adequate oxygen, is the foundation for the current interest in the cancer-cell-specific reprograming of metabolic pathways. The renewed interest in cancer cell metabolism has now gone well beyond the original Warburg effect related to glycolysis to other metabolic pathways that include amino acid metabolism, one-carbon metabolism, the pentose phosphate pathway, nucleotide synthesis, antioxidant machinery, etc. Since glucose and amino acids constitute the primary nutrients that fuel the altered metabolic pathways in cancer cells, the transporters that mediate the transfer of these nutrients and their metabolites not only across the plasma membrane but also across the mitochondrial and lysosomal membranes have become an integral component of the expansion of the Warburg effect. In this review, we focus on the interplay between these transporters and metabolic pathways that facilitates metabolic reprogramming, which has become a hallmark of cancer cells. The beneficial outcome of this recent understanding of the unique metabolic signature surrounding the Warburg effect is the identification of novel drug targets for the development of a new generation of therapeutics to treat cancer.
Hyperthermia in Combination with Emerging Targeted and Immunotherapies as a New Approach in Cancer Treatment
Authors: Logghe Tine , van Zwol Eke , Immordino Benoît , Van den Cruys Kris , Peeters Marc , Giovannetti Elisa , Bogers Johannes
Published: January 2024

Despite significant advancements in the development of novel therapies, cancer continues to stand as a prominent global cause of death. In many cases, the cornerstone of standard-of-care therapy consists of chemotherapy (CT), radiotherapy (RT), or a combination of both. Notably, hyperthermia (HT), which has been in clinical use in the last four decades, has proven to enhance the effectiveness of CT and RT, owing to its recognized potency as a sensitizer. Furthermore, HT exerts effects on all steps of the cancer–immunity cycle and exerts a significant impact on key oncogenic pathways. Most recently, there has been a noticeable expansion of cancer research related to treatment options involving immunotherapy (IT) and targeted therapy (TT), a trend also visible in the research and development pipelines of pharmaceutical companies. However, the potential results arising from the combination of these innovative therapeutic approaches with HT remain largely unexplored. Therefore, this review aims to explore the oncology pipelines of major pharmaceutical companies, with the primary objective of identifying the principal targets of forthcoming therapies that have the potential to be advantageous for patients by specifically targeting molecular pathways involved in HT. The ultimate goal of this review is to pave the way for future research initiatives and clinical trials that harness the synergy between emerging IT and TT medications when used in conjunction with HT.
Mechanism of Selective Qβ Bacteriophage Inactivation under the Presence of E. Coli Using Ground Rh-Doped SrTiO3 Photocatalyst
Authors: Usuki Sho , Machida Shingo , Katsumata Ken-ichi , Ogawa Makoto , Latthe Sanjay S. , Liu Shanhu , Yamatoya Kenji , Nakata Kazuya
Published: January 2024

Photocatalysts have recently attracted attention for removing infectious-disease-causing bacteria and viruses. Among such photocatalysts, ground Rh-doped SrTiO3 (“g-STO:Rh”) has been found to have biospecificity that reduces the Qβ phage infectivity under conditions that did not decrease the E. coli survival rate. Elucidating the mechanism of selective antiphage activation is important for developing photocatalysts that act effectively against specific microorganisms. In this study, SDS-PAGE and quantitative PCR showed that a g-STO:Rh-treated Qβ phage preferentially inactivated the A2 protein involved in attachment to host cells. The analysis of the photocatalyst-treated ovalbumin using g-STO:Rh indicated that the protein’s isoelectric point significantly influenced the initial interaction with g-STO:Rh. However, once the protein is absorbed, it was decomposed without the release of intermediates. Furthermore, an inactivation assay for four different phages by photocatalyst treatment using g-STO:Rh revealed that phages with positively charged proteins are highly susceptible to inactivation, and the accessibility of critical components to g-STO:Rh influences susceptibility. We conclude that the selective antiphage activation of g-STO:Rh depends on the adsorption efficiency of the protein and g-STO:Rh.
Mechanistic and Compositional Aspects of Industrial Catalysts for Selective CO2 Hydrogenation Processes
Authors: Busca Guido , Spennati Elena , Riani Paola , Garbarino Gabriella
Published: January 2024

The characteristics of industrial catalysts for conventional water-gas shifts, methanol syntheses, methanation, and Fischer-Tropsch syntheses starting from syngases are reviewed and discussed. The information about catalysts under industrial development for the hydrogenation of captured CO2 is also reported and considered. In particular, the development of catalysts for reverse water-gas shifts, CO2 to methanol, CO2-methanation, and CO2-Fischer-Tropsch is analyzed. The difference between conventional catalysts and those needed for pure CO2 conversion is discussed. The surface chemistry of metals, oxides, and carbides involved in this field, in relation to the adsorption of hydrogen, CO, and CO2, is also briefly reviewed and critically discussed. The mechanistic aspects of the involved reactions and details on catalysts’ composition and structure are critically considered and analyzed.
Co3O4-rGO—Synthesis, Characterization, and Evaluation of Photocatalytic Activities
Authors: Saeed Muhammad , Albadran Firas H. , Zahoor Ameer Fawad , Nisar Asif , Al-Mutairi Aamal A. , Al-Hussain Sami A. , Irfan Ali , Zaki Magdi E. A.
Published: January 2024

Water contamination with synthetic dyes is an escalating problem worldwide. Herein, Co3O4-decorated reduced graphene oxide (Co3O4-rGO) is reported as an effective heterogeneous photocatalyst for the decomposition of organic dyes. The synthesis of Co3O4-rGO was confirmed via spectroscopic techniques including XRD, XPS, TEM, and FTIR. After characterization, the prepared Co3O4-rGO composite was tested as a photocatalyst for the degradation of methylene blue and methyl orange. The photocatalytic efficiency of Co3O4-rGO was >95% after 60 min, corresponding to 200 mg/L as the initial concentration of each dye. The photodegradation of MB and MO was confirmed by BOD and COD measurements. Experimental parameters like the re-usability of Co3O4-rGO, the effect of catalyst dosage, and the effect of dye concentration on photocatalytic activity were also investigated. The photocatalytic activity of Co3O4-rGO for the degradation of MB was 2.13 and 3.43 times higher than that of Co3O4 and rGO, respectively. Similarly, the photocatalytic activity of Co3O4-rGO for the degradation of MO was 2.36 and 3.56 times higher than that of Co3O4 and rGO, respectively. Hence, Co3O4-rGO was found to be an efficient and reusable photocatalyst for the decomposition of selected dyes in the aqueous medium.
Acyclic Diene Metathesis (ADMET) Polymerization for the Synthesis of Chemically Recyclable Bio-Based Aliphatic Polyesters
Authors: Nomura Kotohiro , Wang Xiuxiu
Published: January 2024

The recent developments of the synthesis of bio-based long-chain aliphatic polyesters by the acyclic diene metathesis (ADMET) polymerization of α,ω-dienes, derived from plant oils and bio-based chemicals, like bis(10-undecenoate) with isosorbide, using ruthenium-carbene catalysts are reviewed. The development of subsequent (one-pot) tandem hydrogenation produced saturated polyesters under mild conditions. The polymerizations under bulk (without solvent, 80–90 °C) or in ionic liquids (50 °C) under vacuum conditions enabled the synthesis of high molar mass polymers (Mn > 30,000 g/mol). The polymerization performed by the molybdenum-alkylidene catalyst afforded the highest-molecular-weight polyesters (44,000–49,400 g/mol, in toluene at 25 °C) exhibiting promising tensile properties (strength and elongation at break) compared to polyethylene and polypropylene. Depolymerizations of these polyesters, including closed-loop chemical recycling, were also demonstrated. Catalyst developments (more active, under mild conditions) play a key role in the efficient synthesis of these materials.
A New Synthesized Dicarboxylated Oxy-Heparin Efficiently Attenuates Tumor Growth and Metastasis
Authors: Li Li , Barash Uri , Ilan Neta , Farhoud Malik , Zhang Xiao , Vlodavsky Israel , Li Jin-Ping
Published: January 2024

Heparanase (Hpa1) is expressed by tumor cells and cells of the tumor microenvironment and functions to remodel the extracellular matrix (ECM) and regulate the bioavailability of ECM-bound factors that support tumor growth. Heparanase expression is upregulated in human carcinomas, sarcomas, and hematological malignancies, correlating with increased tumor metastasis, vascular density, and shorter postoperative survival of cancer patients, and encouraging the development of heparanase inhibitors as anti-cancer drugs. Among these are heparin/HS mimetics, the only heparanase-inhibiting compounds that are being evaluated in clinical trials. We have synthesized dicarboxylated oxy-heparins (DCoxHs) containing three carboxylate groups per split residue (DC-Hep). The resulting lead compound (termed XII) was upscaled, characterized, and examined for its effectiveness in tumor models. Potent anti-tumorigenic effects were obtained in models of pancreatic carcinoma, breast cancer, mesothelioma, and myeloma, yielding tumor growth inhibition (TGI) values ranging from 21 to 70% and extending the survival time of the mice. Of particular significance was the inhibition of spontaneous metastasis in an orthotopic model of breast carcinoma following resection of the primary tumor. It appears that apart from inhibition of heparanase enzymatic activity, compound XII reduces the levels of heparanase protein and inhibits its cellular uptake and activation. Heparanase-dependent and -independent effects of XII are being investigated. Collectively, our pre-clinical studies with compound XII strongly justify its examination in cancer patients.
A Systematic Review on Assessing Assessments: Unveiling Psychometric Properties of Instruments for Reactive Attachment Disorder and Disinhibited Social Engagement Disorder in Minors under Protective Measures
Authors: Talmón-Knuser Florencia , Soler Miriam , González-Sala Francisco , Lacomba-Trejo Laura , Samper-García Paula
Published: January 2024

Background: Reactive attachment disorder (RAD) and disinhibited social engagement disorder (DSED) manifest in individuals facing attachment system challenges, particularly observed in minors under protective measures. The lack of standardized tools for assessing these difficulties and uncertainty about the most effective instruments from a psychometric perspective prompted this study. Aim: Using the COSMIN checklist, we systematically reviewed instruments assessing RAD, adhering to PRISMA. Methodology: Examined tools included the Disturbance Attachment Interview, Preschool Age Psychiatric Assessment, Relationship Patterns Questionnaire, Assessment of RAD and DSED, Development and Well-Being Assessment, and Reactive Attachment Disorder Questionnaire. Results: Of the 10 articles analyzed, the results highlight a research emphasis on internal consistency and structural and construct validity, sidelining other properties. Conclusion: Most articles review structural validity and internal consistency. These measures are satisfactory but insufficiently evaluated. It is necessary to evaluate these tools using other indicators such as cross-cultural validity, measurement error, or responsiveness in adolescents under protective measures.
Secondary Carnitine Deficiency in Neonates and Infants Requiring Surgery for Intestinal Obstructions—An Underestimated and Undermanaged Problem
Authors: Huang Sheng-Yang , Chou Chia-Man , Chen Hou-Chuan
Published: January 2024

This study aims to elucidate the relationship between intestinal obstruction and carnitine deficiency in neonates and infants. We retrospectively reviewed medical records of 330 neonates and infants, younger than six months, who underwent surgery for intestinal obstruction at our institute from January 2009 to April 2022. The analysis focused on clinical symptoms, related signs, complications, and etiology of the intestinal obstruction. Tandem mass spectrometry (MS/MS) or urine organic acid analysis was conducted for 47 patients, revealing carnitine deficiency in 16 patients. The incidence of carnitine deficiency was 34.0% in the suspicious group and 4.8% overall, significantly higher than in the general population in Taiwan. Notably, patients with carnitine deficiency experienced prolonged ileus, with a mean fasting duration of 41.7 days (range 7.8–65.5 days), compared to 10.8 days (range 8.2–13.4 days) in patients without carnitine deficiency. Carnitine replacement therapy was administered to twelve patients at dosages ranging from 32 to 90 mg/kg/day. One patient exhibited a drug allergy with skin rashes. Our findings suggest that carnitine deficiency should be considered in cases of neonatal and infant intestinal obstruction. Replacement therapy is straightforward and can be prognostically beneficial for some patients. Therefore, we recommend generalizing MS/MS and urine organic acid analysis, particularly for patients with prolonged ileus.
Coffee and Microbiota: A Narrative Review
Authors: Rosa Federico , Marigliano Benedetta , Mannucci Sergio , Candelli Marcello , Savioli Gabriele , Merra Giuseppe , Gabrielli Maurizio , Gasbarrini Antonio , Franceschi Francesco , Piccioni Andrea
Published: January 2024

Coffee is one of the most widely consumed beverages in the world, which has important repercussions on the health of the individual, mainly because of certain compounds it contains. Coffee consumption exerts significant influences on the entire body, including the gastrointestinal tract, where a central role is played by the gut microbiota. Dysbiosis in the gut microbiota is implicated in the occurrence of numerous diseases, and knowledge of the microbiota has proven to be of fundamental importance for the development of new therapeutic strategies. In this narrative review, we thoroughly investigated the link between coffee consumption and its effects on the gut microbiota and the ensuing consequences on human health. We have selected the most significant articles published on this very interesting link, with the aim of elucidating the latest evidence about the relationship between coffee consumption, its repercussions on the composition of the gut microbiota, and human health. Based on the various studies carried out in both humans and animal models, it has emerged that coffee consumption is associated with changes in the gut microbiota, although further research is needed to understand more about this link and the repercussions for the whole organism.
In Vitro Anti-Inflammatory Study of Limonoids Isolated from Chisocheton Plants
Authors: Hilmayanti Erina , Huang Xuhao , Salam Supriatno , Nurlelasari  , Supratman Unang , Kabayama Kazuya , Fukase Koichi
Published: January 2024

Chisocheton plants from the family Meliaceae have traditionally been used to treat several diseases; however, scientific evidence is limited. The most abundant chemical constituents of this plant are the limonoids, which are known for their various biological activities, including anti-inflammatory effects. However, the anti-inflammatory effects and underlying mechanisms of action of the constituents of Chisocheton plants have not been fully explored. In this report, we evaluated the anti-inflammatory activity of 17 limonoid compounds from Chisocheton plant primarily by measuring their inhibitory effects on the production of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, and MCP-1, in LPS-stimulated THP-1 cells using an ELISA assay. Compounds 3, 5, 9, and 14–17 exhibited significant activity in inhibiting the evaluated pro-inflammatory markers, with IC50 values less than 20 µM and a high selectivity index (SI) range. Compounds 3, 5, 9, and 15 significantly suppressed the expression of phosphorylated p38 MAPK in THP-1 cells stimulated with LPS. These findings support the use of limonoids from Chisocheton plants as promising candidates for anti-inflammatory therapy.
Evaluation of the Reparative Effect of Sinomenine in an Acetaminophen-Induced Liver Injury Model
Authors: Kayalı Ahmet , Bora Ejder Saylav , Acar Hüseyin , Erbaş Oytun
Published: January 2024

Due to its rising global prevalence, liver failure treatments are urgently needed. Sinomenine (SIN), an alkaloid from sinomenium acutum, is being studied for its liver-repair properties due to Acetaminophen (APAP) overdose. SIN’s effect on APAP-induced hepatotoxicity in rats was examined histologically and biochemically. Three groups of 30 adult male Wistar rats were created: control, APAP-only, and APAP + SIN. Histopathological and biochemical analyses were performed on liver samples after euthanasia. SIN is significantly protected against APAP damage. Compared to APAP-only, SIN reduced cellular injury and preserved hepatocellular architecture. The APAP + SIN Group had significantly lower ALT, MDA, and GSH levels, protecting against hepatocellular damage and oxidative stress. SIN also had dose-dependent antioxidant properties. When examining critical regulatory proteins, SIN partially restored Sirtuin 1 (SIRT1) levels. While BMP-7 levels were unaffected, histopathological evidence and hepatocyte damage percentages supported SIN’s liver-restorative effect. SIN protected and repaired rats’ livers from APAP-induced liver injury. This study suggests that SIN may treat acute liver damage, warranting further research into its long-term effects, optimal dosage, and clinical applications. These findings aid liver-related emergency department interventions and life-saving treatments.
A Comparison Study on the Microstructure, Mechanical Features, and Tribological Characteristics of TiN Coatings on Ti6Al4V Using Different Deposition Techniques
Authors: Liu Zhen , Ren Shuai , Li Tijun , Chen Pinghu , Hu Liangbin , Wu Wenxing , Li Sheng , Liu Hao , Li Ruiqing , Zhang Yun
Published: January 2024

Titanium alloys are considered lightweight alloys and are widely applied across various industries. However, their low hardness, poor wear resistance, and limited oxidation resistance restrict their prospects for wider application. In this paper, nitride coatings were prepared using three preparation processes, namely laser surface nitriding (LSN), physical vapor deposition (PVD), and plasma ion implantation (PII). Their microstructure, microhardness, tribological behavior, and high-temperature oxidation characteristics were compared. The experimental results revealed that nitrided coatings were successfully prepared using the three methods. However, a comparison of these data shows that the LSN coating exhibited superior comprehensive performance. It achieved the maximum thickness within the shortest preparation time: the thickness was about 280 μm and the deposition rate of the LSN method was 2250 and 90,000 times higher than those of the PVD and PII methods. Nitrides have high hardness, but the carrying capacity could be attributed to the thickness of the coatings: the PVD coating could withstand a force of 500 g, while the PII coating only withstood a force of less than 25 g. In addition, as hardness is the most important factor for excellent wear resistance, the average volumetric wear rate of the LSN and PVD coatings was about 9 × 10−6 mm3/m·N, and their relative wear resistance was 49.2 times that of Ti6Al4V. Meanwhile, the excellent bond between the LSN coating and the substrate was evidenced by a high-temperature oxidation test during a rapid heating–cooling cycle.
Financial Market Stress and Commodity Returns: A Dynamic Approach
Authors: Adhikari Ramesh , Putnam Kyle J.
Published: January 2024

This paper examines the relationship between commodity index returns and the Office of Financial Research Financial Stress Index (OFR FSI). Utilizing the S&P GSCI and its five sub-indices (agriculture, livestock, energy, industrial metals, and precious metals), we find that the causal relationship between financial market stress and commodity index returns is conditional on the sample period examined and the methodology employed. We also note that stress in financial markets has a negative relationship with commodity index returns during low commodity return states; however, during high commodity return states, financial market stress exhibits a positive relationship with commodity index returns. Our findings highlight the importance of considering a time-varying framework for analyzing commodity return dynamics.
Cooperation Dynamic through Individualistic Indirect Reciprocity Mechanism in a Multi-Dynamic Model
Authors: González-Silva Mario-Ignacio , González-Silva Ricardo-Armando
Published: January 2024

This research proposes a new variant of Nowak and Sigmund’s indirect reciprocity model focused on agents’ individualism, which means that an agent strengthens its profile to the extent to which it makes a profit; this is using agent-based modeling. In addition, our model includes environmentally related conditions such as visibility and cooperative demand and internal poses such as obstinacy. The simulation results show that cooperators appear in a more significant proportion with conditions of low reputation visibility and high cooperative demand. Still, severe defectors take advantage of this situation and exceed the cooperators’ ratio. Some events show a heterogeneous society only with conditions of high obstinacy and cooperative demand. In general, the simulations show diverse scenarios, including centralized, polarized, and mixed societies. Simulation results show no healthy cooperation in indirect reciprocity due to individualism.
An Overview of Proprietary Vehicles/Bases for Topical Compounding Medicines and Cosmetics
Authors: Torres Ana , Almeida Isabel F. , Oliveira Rita
Published: January 2024

Compounding is currently an integral part of pharmacy practice, and it is essential to the provision of healthcare. Compounding is an important therapeutic option in all areas of medicine, with relevance to dermatological treatments. Compounding topical medicines can be time-consuming and requires specialized equipment. In this regard, the use of proprietary topical liquid and semisolid vehicles/bases can be a good alternative and a more sustainable approach. This review provides an overview of existing proprietary vehicles/bases, summarizing their properties and applications and identifying existing commercial and information gaps. Creams emerge as the foremost topical base, followed by gels and ointments. Besides acting locally on the skin, almost a third of these proprietary bases/vehicles are also suitable for the transdermal application of APIs. Information regarding composition and compatibilities/incompatibilities with APIs is not always provided by the manufacturer, constraining a complete analysis of all proprietary topical bases/vehicles considered. The collection and organization of this information are important not only for pharmacy practice and physician prescription, helping to select the best vehicles/bases, but also for the industry to identify opportunities for innovation.
Novel and Efficient Privacy-Preserving Continuous Authentication
Authors: Baig Ahmed Fraz , Eskeland Sigurd , Yang Bian
Published: January 2024

Continuous authentication enhances security by re-verifying a user’s validity during the active session. It utilizes data about users’ behavioral actions and contextual information to authenticate them continuously. Such data contain information about user-sensitive attributes such as gender, age, contextual information, and may also provide information about the user’s emotional states. The collection and processing of sensitive data cause privacy concerns. In this paper, we propose two efficient protocols that enable privacy-preserving continuous authentication. The contribution is to prevent the disclosure of user-sensitive attributes using partial homomorphic cryptographic primitives and reveal only the aggregated result without the explicit use of decryption. The protocols complete an authentication decision in a single unidirectional transmission and have very low communication and computation costs with no degradation in biometric performance.
TEM Image Analysis and Simulation Physics for Two-Step Recrystallization of Discretely Amorphized C3H5-Molecular-Ion-Implanted Silicon Substrate Surface
Authors: Kobayashi Koji , Okuyama Ryosuke , Kadono Takeshi , Onaka-Masada Ayumi , Hirose Ryo , Suzuki Akihiro , Koga Yoshihiro , Sueoka Koji , Kurita Kazunari
Published: January 2024

In this study, we investigate the initial rapid recrystallization of a discretely amorphized C3H5-molecular-ion-implanted silicon (Si) substrate surface in the subsequent thermal annealing treatment through the analysis of plan-view transmission electron microscopy (TEM) images and technology computer-aided design (TCAD) process simulation. In the approach of the analysis of the plan-view TEM image of the Si substrate surface, we found that initial rapid recrystallization occurs in the intermediate regions between the residual crystalline and discrete amorphous regions formed in the C3H5-molecular-ion-implanted Si substrate surface. In addition, the TCAD process simulation results indicate that the intermediate regions correspond to the amorphous pockets formed around the discrete amorphous regions in the C3H5-molecular-ion-implanted Si substrate surface and are recrystallized preferentially during the short thermal annealing time. These plan-view TEM image analysis and TCAD process simulation results reveal a two-step recrystallization of the discretely amorphized C3H5-molecular-ion-implaned Si substrate surface. After the initial rapid recrystallization of amorphous pockets in the 1st step, the recrystallization of discrete amorphous regions starts in the 2nd step. The incubation period between the 1st and 2nd steps is the time required to recrystallize the amorphous pockets around the discrete amorphous regions completely and redefine the amorphous/crystalline interface.
Effect of Mo on the Corrosion Resistance of Cr-Containing Steel in a Simulated Tropical Marine Atmospheric Environment
Authors: Wang Ningxi , Gao Jianzhuo , Xu Xuexu
Published: January 2024

In this manuscript, the effect of Mo addition on the corrosion resistance of the low-alloy steel in a simulated tropical marine atmospheric environment has been studied through microstructure characterization, corrosion immersion experiments, electrochemical measurement, and a series of microscopic characterization methods. The results show that Mo has the ability to reduce the corrosion rate of low-alloy steel in a marine atmospheric environment, with a more pronounced reduction effect observed over longer corrosion periods. The addition of Mo enhances the corrosion product film’s compactness when coupled with Cr, subsequently improving corrosion resistance. Simultaneously, MoO42−, acting as a slow-release ion, can effectively suppress localized corrosion in low-alloy steel. The research findings can offer data support and a theoretical foundation for the design of low-alloy steels with enhanced corrosion resistance in a tropical marine atmospheric environment.