bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Load Change on the Thevenin Equivalent Impedance of Power System
Authors: Sun Tiankui , Li Zhimin , Rong Shuang , Lu Jian , Li Weixing
Published: March 2017

This paper discusses the effect of load change on the Thevenin equivalent impedance of power systems. In this paper, the Thevenin equivalent impedance influenced by the derivative of active load with respect to reactive load (dP dQ) is analyzed. The Thevenin equivalent impedance forms a closed curve in a complex plane and shrinks to one point when voltage collapses. The magnitude of the Thevenin equivalent impedance at the collapse point is equal to the magnitude of the load impedance. Therefore, the impedance match theory still holds under the effect of the load change. These features are verified on a New England 39-bus system.
Signal-Based Gas Leakage Detection for Fluid Power Accumulators in Wind Turbines
Authors: Liniger Jesper , Sepehri Nariman , Soltani Mohsen , Pedersen Henrik
Published: March 2017

This paper describes the development and application of a signal-based fault detection method for identifying gas leakage in hydraulic accumulators used in wind turbines [...]
Unreliability and the Animal Narrator in Richard Adams’s The Plague Dogs
Authors: Höing Anja
Published: March 2017

Richard Adams’s talking animal story The Plague Dogs (1978), with its deeply genre-atypical mode of narration, offers a multiplicity of avenues to explore the literary animal as animal. The story draws much of its power from the psychological complexity and related unreliability of both canine narrators, two research lab escapees gone feral. Both the terrier Snitter and the black mongrel Rowf are mentally ill and experience a highly subjective, part-fantastic world. In episodes of zero focalization, a sarcastic voice comments on the plot from the off, aggressively attacking a thoroughly anthropocentric superstructure the protagonists themselves are oblivious of, and presenting all that is normally constructed as “rational” in the implied reader’s world as a carnivalesque farce. Combining these equally unreliable narratives, The Plague Dogs creates a unique mixture of what Phelan (2007) calls “estranging” and “bonding” unreliability and brings to light the devastating consequences of anthropocentrism. The Plague Dogs not only defamiliarizes a genre usually committed to conventional means of storytelling, but the dominant Western conception of the status of animals in the world, showing that once we start to read the animal as animal, this sets into motion an avalanche of other concepts in need of re-reading, among them the very ones making up the fundamental pillars of Western societies’ anthropocentric self-conception.
Comments by the Academic Editors to Responses and Replies Concerning Mroczek et al.’s “Evaluation of Quality of Life of Those Living near a Wind Farm“: Int. J. Environ. Res. Public Health 2015, 12, 6066–6083
Authors: Lercher Peter , Tchounwou Paul
Published: March 2017

We are aware of the current divide in the scientific assessment of the potential health effects of wind turbine installations.[...]
Optimizing Scoring and Sampling Methods for Assessing Built Neighborhood Environment Quality in Residential Areas
Authors: Adu-Brimpong Joel , Coffey Nathan , Ayers Colby , Berrigan David , Yingling Leah , Thomas Samantha , Mitchell Valerie , Ahuja Chaarushi , Rivers Joshua , Hartz Jacob , Powell-Wiley Tiffany
Published: March 2017

Optimization of existing measurement tools is necessary to explore links between aspects of the neighborhood built environment and health behaviors or outcomes. We evaluate a scoring method for virtual neighborhood audits utilizing the Active Neighborhood Checklist (the Checklist), a neighborhood audit measure, and assess street segment representativeness in low-income neighborhoods. Eighty-two home neighborhoods of Washington, D.C. Cardiovascular Health/Needs Assessment (NCT01927783) participants were audited using Google Street View imagery and the Checklist (five sections with 89 total questions). Twelve street segments per home address were assessed for (1) Land-Use Type; (2) Public Transportation Availability; (3) Street Characteristics; (4) Environment Quality and (5) Sidewalks/Walking/Biking features. Checklist items were scored 0–2 points/question. A combinations algorithm was developed to assess street segments’ representativeness. Spearman correlations were calculated between built environment quality scores and Walk Score®, a validated neighborhood walkability measure. Street segment quality scores ranged 10–47 (Mean = 29.4 ± 6.9) and overall neighborhood quality scores, 172–475 (Mean = 352.3 ± 63.6). Walk scores® ranged 0–91 (Mean = 46.7 ± 26.3). Street segment combinations’ correlation coefficients ranged 0.75–1.0. Significant positive correlations were found between overall neighborhood quality scores, four of the five Checklist subsection scores, and Walk Scores® (r = 0.62, p < 0.001). This scoring method adequately captures neighborhood features in low-income, residential areas and may aid in delineating impact of specific built environment features on health behaviors and outcomes.
Utilizing Crowdsourced Data for Studies of Cycling and Air Pollution Exposure: A Case Study Using Strava Data
Authors: Sun Yeran , Mobasheri Amin
Published: March 2017

With the development of information and communications technology, user-generated content and crowdsourced data are playing a large role in studies of transport and public health. Recently, Strava, a popular website and mobile app dedicated to tracking athletic activity (cycling and running), began offering a data service called Strava Metro, designed to help transportation researchers and urban planners to improve infrastructure for cyclists and pedestrians. Strava Metro data has the potential to promote studies of cycling and health by indicating where commuting and non-commuting cycling activities are at a large spatial scale (street level and intersection level). The assessment of spatially varying effects of air pollution during active travel (cycling or walking) might benefit from Strava Metro data, as a variation in air pollution levels within a city would be expected. In this paper, to explore the potential of Strava Metro data in research of active travel and health, we investigate spatial patterns of non-commuting cycling activities and associations between cycling purpose (commuting and non-commuting) and air pollution exposure at a large scale. Additionally, we attempt to estimate the number of non-commuting cycling trips according to environmental characteristics that may help identify cycling behavior. Researchers who are undertaking studies relating to cycling purpose could benefit from this approach in their use of cycling trip data sets that lack trip purpose. We use the Strava Metro Nodes data from Glasgow, United Kingdom in an empirical study. Empirical results reveal some findings that (1) when compared with commuting cycling activities, non-commuting cycling activities are more likely to be located in outskirts of the city; (2) spatially speaking, cyclists riding for recreation and other purposes are more likely to be exposed to relatively low levels of air pollution than cyclists riding for commuting; and (3) the method for estimating of the number of non-commuting cycling activities works well in this study. The results highlight: (1) a need for policymakers to consider how to improve cycling infrastructure and road safety in outskirts of cities; and (2) a possible way of estimating the number of non-commuting cycling activities when the trip purpose of cycling data is unknown.
Metal Concentrations in Newcomer Women and Environmental Exposures: A Scoping Review
Authors: Chen Shirley , Wiseman Clare , Chakravartty Dolon , Cole Donald
Published: March 2017

Newcomer women from developing countries are recognized to be at risk for elevated exposures to environmental contaminants and associated negative health effects. As such, data on exposure sources and contaminant body burden concentrations is critical in the development of effective public health policies and interventions in support of newcomer health. We conducted a scoping review to gather evidence on important toxic metals of health concern, lead (Pb), mercury (Hg) and cadmium (Cd), and their concentrations and potential exposure sources among newcomer women. An initial 420 articles were identified through the databases MEDLINE, EMBASE and Scopus, many reporting by ethnicity rather than newcomer/immigrant status. Several articles reported metal concentrations for other biomarkers but did not include blood, nor stratify results. From the remainder, we selected a total of 10 articles for full textual review, which reported blood Pb, Hg or Cd levels for newcomer women and/or stratified blood metal results according to foreign birth or country of origin. Three of the articles reported higher Pb, Hg and Cd concentrations in newcomer women compared to their native-borne counterparts. Exposures identified as contributing to elevated Pb, Hg and Cd blood concentrations included: pica behaviour, the use of lead-glazed cookware or eye cosmetics, and fish/shellfish consumption. The review revealed a limited availability of data on metal body burden concentrations, exposure sources and routes among newcomer women specifically. More research is needed to better understand the extent to which newcomer women are disproportionately at risk of elevated metal exposures due to either country of origin or current exposures and to inform relevant, multi-national risk management strategies.
Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist
Authors: Sai Wenbo , Tian Hong , Yang Kangmin , Tang Daoqi , Bao Jinxiao , Ge Yang , Song Xiaoda , Zhang Yu , Luo Cheng , Gao Xiangdong , Yao Wenbing
Published: March 2017

Exendin-4 is a strong therapeutic candidate for the treatment of metabolic syndrome. Related receptor agonist drugs have been on the market since 2005. However, technical limitations and the pain caused by subcutaneous injection have severely limited patient compliance. The goal of the study is to investigate a biologically active exendin-4 analog could be administered orally. Using intraperitoneal glucose tolerance tests, we discovered that exendin4-cysteine administered by oral gavage had a distinct hypoglycemic effect in C57BL/6J mice. Using Rosetta Design and Amber, we designed and screened a series of exendin4-cysteine analogs to identify those that retained biological activity while resisting trypsin digestion. Trypsin Cleavage Site Mutated Exendin4-cysteine 1 (TSME-1), an analog whose bioactivity was similar to exendin-4 and was almost completely resistant to trypsin, was screened out. In addition, TSME-1 significantly normalized the blood glucose levels and the availability of TSME-1 was significantly higher than that of exendin-4 and exendin4-cysteine. Collectively orally administered TSME-1, a trypsin-resistant exendin-4 analog obtained by the system, is a strong candidate for future treatments of type 2 diabetes.
Higher Levels of Serum Zonulin May Rather Be Associated with Increased Risk of Obesity and Hyperlipidemia, Than with Gastrointestinal Symptoms or Disease Manifestations
Authors: Ohlsson Bodil , Orho-Melander Marju , Nilsson Peter
Published: March 2017

Zonulin is considered a biomarker of increased intestinal permeability, and elevated levels have been found in celiac disease. The primary aim of this study was to examine the association between serum zonulin levels and gastrointestinal (GI) symptoms, and secondarily, between zonulin levels and anthropometric and metabolic factors. The offspring (n = 363) of the participants of the Malmö Diet and Cancer cardiovascular cohort (MDC-CV) were invited to an anthropometric and clinical examination, where fasting plasma glucose levels were measured. Questionnaires about lifestyle factors and medical history were completed along with the Visual Analog Scale for Irritable Bowel Syndrome (VAS-IBS). Zonulin levels were measured in serum by ELISA. Neither GI symptoms nor GI diseases had any influence on zonulin levels. Higher zonulin levels were associated with higher waist circumference (p = 0.003), diastolic blood pressure (p = 0.003), and glucose levels (p = 0.036). Higher zonulin levels were associated with increased risk of overweight (p < 0.001), obesity (p = 0.047), and hyperlipidemia (p = 0.048). We cannot detect altered zonulin levels among individuals reporting GI symptoms or GI diseases, but higher zonulin levels are associated with higher waist circumference, diastolic blood pressure, fasting glucose, and increased risk of metabolic diseases.
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42
Authors: Xu Yongru , Qi Yingzi , Luo Jing , Yang Jing , Xie Qi , Deng Chen , Su Na , Wei Wei , Shi Deshun , Xu Feng , Li Xiangping , Xu Ping
Published: March 2017

Chronic hepatitis B virus (HBV) infection has been considered as the major cause of hepatocellular carcinoma (HCC). Hepatitis B virus X protein (HBx) has been reported to be oncogenic. The underlying mechanisms of HBV-related HCC are not fully understood, and the role played by the HBx protein in HBV induced carcinogenesis remains controversial. CDC42, a member of the Rho GTPase family, has been reported to be overexpressed in several different cancers, including HBV-related HCC. However, the specific role of CDC42 in HCC development remains unclear. Here, we investigated the cellular mechanisms by which CDC42 was responsible for the higher proliferation of HuH-7 cells mediated by HBx. We found that the expression level of CDC42 and its activity were significantly increased in HuH-7-HBx cells. The deficiency of CDC42 using the CRISPR/Cas9 system and inhibition by specific inhibitor CASIN led to the reduction of HBx-mediated proliferation. Furthermore, we observed that IQ Motif Containing GTPase Activating Protein 1 (IQGAP1), the downstream mediator of the CDC42 pathway, might be involved in the carcinogenesis induced by HBx. Therefore, the HBx/CDC42/IQGAP1 signaling pathway may potentially play an important role in HBx-mediated carcinogenesis.
Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice
Authors: Zhao Jun , Zhang Shilei , You Shuping , Liu Tao , Xu Fang , Ji Tengfei , Gu Zhengyi
Published: March 2017

Nymphaea candida was used to treat hepatitis in Ugyhur medicine, and nicotiflorin (kaempferol 3-O-β-rutinoside) is the main characteristic component in this plant. In this study, The the hepatoprotective activities of nicotiflorin from N. candida were investigated by Concanavalin A (Con A, 20 mg/kg bw)- and d-Galactosamine (d-GalN, 800 mg/kg bw)-induced acute liver injury in mice. Pretreatment with nicotiflorin (25, 50, 100 mg/kg bw/day, p.o.) for ten days significantly reduced the impact of Con A toxicity (20 mg/kg bw) on the serum markers of liver injury, aspartate aminotransferase (AST), and alanine aminotransferase (ALT). The hepatic anti-oxidant parameters (malondialdehyde, MDA; superoxide dismutase, SOD; glutathione, GSH; and nitric oxide, NO) in mice with nicotiflorin treatment were significantly antagonized for the pro-oxidant effects of Con A. Moreover, pretreatment with nicotiflorin (100 mg/kg bw) significantly decreased Con A-induced elevation in the serum levels of pro-inflammatory cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) (p < 0.05). A protective effect was reconfirmed against d-GalN-induced chemical liver injury, elevated serum enzymatic and cytokines levels were significantly decreased by nicotiflorin, and liver homogenate antioxidant indicators were significantly restored toward normal levels. Both histopathological studies also supported the protective effects of nicotiflorin. Therefore, the presented results suggest that nicotiflorin is the potent hepatoprotective agent that could protect the liver against acute immunological and chemical injury; this ability might be attributed to its antioxidant and immunoregulation potential.
Neurogenic Effects of Ghrelin on the Hippocampus
Authors: Kim Chanyang , Kim Sehee , Park Seungjoon
Published: March 2017

Mammalian neurogenesis continues throughout adulthood in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus. It is well known that hippocampal neurogenesis is essential in mediating hippocampus-dependent learning and memory. Ghrelin, a peptide hormone mainly synthesized in the stomach, has been shown to play a major role in the regulation of energy metabolism. A plethora of evidence indicates that ghrelin can also exert important effects on neurogenesis in the hippocampus of the adult brain. The aim of this review is to discuss the current role of ghrelin on the in vivo and in vitro regulation of neurogenesis in the adult hippocampus. We will also discuss the possible role of ghrelin in dietary restriction-induced hippocampal neurogenesis and the link between ghrelin-induced hippocampal neurogenesis and cognitive functions.
Astaxanthin Inhibits PC-3 Xenograft Prostate Tumor Growth in Nude Mice
Authors: Ni Xiaofeng , Yu Haining , Wang Shanshan , Zhang Chengcheng , Shen Shengrong
Published: March 2017

Prostate cancer (PCa), the most common malignancy in men, is a major cause of cancer deaths. A better understanding of the mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment of this patient group. As a dietary carotenoid, astaxanthin has been demonstrated to exert beneficial effects against inflammation, cardiovascular disease, oxidative damage, or different cancer sites. This study used intragastric administration of astaxanthin to detect its role on tumor proliferation, apoptosis, microRNA (miRNA) overexpression, and microbacteria composition change by establishing androgen-independent PCa cell PC-3 xenograft nude mice. Nude mice were inoculated with androgen-independent prostate cancer PC-3 cells subcutaneously. The intervention was started when tumors reached 0.5–0.6 cm in diameter. Mice were intragastrically administered 100 mg/kg astaxanthin (HA), 25 mg/kg astaxanthin (LA), or olive oil (TC). The results showed that 100 mg/kg astaxanthin significantly inhibited tumor growth compared to the TC group, with an inhibitory rate of 41.7%. A decrease of Ki67 and proliferating cell nuclear antigen (PCNA) as well as an increase of cleaved caspase-3 were observed in HA-treated tumors, along with increasing apoptotic cells, obtained by TUNEL assay. The HA significantly elevated the levels of tumor suppressors miR-375 and miR-487b in tumor tissues and the amount of Lactobacillus sp. and Lachnospiraceae in mice stools, while there was no significant difference between LA and TC groups. These results provide a promising regimen to enhance the therapeutic effect in a dietary supplement manner.
A Prospective Randomized Trial of Postural Changes vs Passive Supine Lying during the Second Stage of Labor under Epidural Analgesia
Authors: Simarro María , Espinosa José , Salinas Cecilia , Ojea Ricardo , Salvadores Paloma , Walker Carolina , Schneider José
Published: March 2017

There exist very few studies comparing different postures or postural changes during labor in parturients with epidural analgesia. Aim: To disclose whether the intervention of a multidisciplinary nursing team including a physiotherapist during the second stage of labor improves the obstetric outcome in parturients with epidural analgesia. Design: Prospective randomized trial. Setting: University-affiliated hospital. Population: Women undergoing labor with epidural analgesia after a normal gestation. Methods: 150 women were randomized either to actively perform predefined postural changes during the passive phase of the second stage of labor under the guidance of the attending physiotherapist (study group), or to carry out the whole second stage of labor lying in the traditional supine position (control group). Results: There were significantly more eutocic deliveries (p = 0.005) and, conversely, significantly less instrumental deliveries (p < 0.05) and cesarean sections (p < 0.05) in the study group. The total duration of the second stage of labor was significantly shorter (p < 0.01) in the study group. This was at the expense of the passive phase of the second stage of labor (p < 0.01). Significantly less episiotomies were performed in the study group (31.2% vs 17.8%, p < 0.05). Conclusion: The intervention of a physiotherapist during the second stage of labor significantly improved the obstetric outcome.
Anti-Influenza Virus (H5N1) Activity Screening on the Phloroglucinols from Rhizomes of Dryopteris crassirhizoma
Authors: Wang Juan , Yan Yan-Tao , Fu Shen-Zhen , Peng Bing , Bao Lin-Lin , Zhang Yan-Ling , Hu Jing-Hong , Zeng Zu-Ping , Geng Dong-Hao , Gao Zeng-Ping
Published: March 2017

For screening the active phloroglucinols on influenza virus (H5N1) from Dryopteris crassirhizoma NaKai, a database was established including twenty-three phloroglucinols that had been isolated from Dryopteris crassirhizoma. Their inhibitory effect on the neuraminidase (NA) of influenza virus H5N1 was screened by molecular docking. As a result, three candidates were selected. The rhizomes of D. crassirhizoma were subjected to isolation and purification processes to obtain the inhibitor candidates. Thirteen phloroglucinols were obtained, including three selected candidates and two new phloroglucinols. The five phloroglucinols were investigated for their inhibitory activity on NA in vitro. The results showed that dryocrassin ABBA and filixic acid ABA exhibited inhibitory effects on NA with IC50 as 18.59 ± 4.53 and 29.57 ± 2.48 μM, respectively, and the other three phloroglucinols showed moderate inhibitory activity. Moreover, the anti-influenza virus (H5N1) activity and cytotoxicity of dryocrassin ABBA and filixic acid ABA were tested on Madin-Darby canine kidney (MDCK) cells with the cell counting kit-8 (CCK8) method. The results confirmed that dryocrassin ABBA exhibited an inhibitory activity with low cytotoxicity (TC50 > 400 μM) against influenza virus (H5N1) which will have to be investigated in further detail. In conclusion, phloroglucinols from D. crassirhizoma were shown to have anti-influenza virus activity, and especially dryocrassin ABBA, one of the phloroglucinols, may have the potential to control influenza virus (H5N1) infection.
The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli
Authors: Ran Rensen , Zeng Huan , Zhao Dong , Liu Ruiyuan , Xu Xia
Published: March 2017

Microcin C7 (McC), widely distributed in enterobacteria, is a promising antibiotic against antibiotic resistance [...]
Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart
Authors: Pipicz Márton , Kocsis Gabriella , Sárváry-Arantes László , Bencsik Péter , Varga Zoltán , Ferdinandy Péter , Csont Tamás
Published: March 2017

Administration of low-dose endotoxin (lipopolysaccharide, LPS) 24 h before a lethal ischemia induces pharmacological late preconditioning. The exact mechanism of this phenomenon is not clear. Here we aimed to investigate whether low-dose LPS exerts late effects on peroxynitrite formation and activation of Akt, Erk, and STAT3 in the heart. Male Wistar rats were injected with LPS (S. typhimurium; 0.5 mg/kg i.p.) or saline. Twenty-four hours later, hearts were isolated, perfused for 10 min, and then used for biochemical analyses. LPS pretreatment enhanced cardiac formation of the peroxynitrite marker 3-nitrotyrosine. LPS pretreatment also increased cardiac levels of the peroxynitrite precursor nitric oxide (NO) and superoxide. The activities of Ca2+-independent NO synthase and xanthine oxidoreductase increased in LPS-pretreated hearts. LPS pretreatment resulted in significantly enhanced phosphorylation of STAT3 and non-significantly increased phosphorylation of Akt without affecting the activation of Erk. In separate experiments, isolated working hearts were subjected to 30 min global ischemia and 20 min reperfusion. LPS pretreatment significantly improved ischemia-reperfusion-induced deterioration of cardiac function. We conclude that LPS pretreatment enhances cardiac peroxynitrite formation and activates STAT3 24 h later, which may contribute to LPS-induced late preconditioning.
Lean Fish Consumption Is Associated with Beneficial Changes in the Metabolic Syndrome Components: A 13-Year Follow-Up Study from the Norwegian Tromsø Study
Authors: Tørris Christine , Molin Marianne , Småstuen Milada
Published: March 2017

Background: Fish consumption may have beneficial effects on metabolic syndrome (MetS); however, limited information of such associations exists. This study investigated possible associations between fish consumption and changes in MetS components during a 13-year follow-up period. Methods: The sample included participants (26–69 years) from the Tromsø Study 4 (1994–1995, n = 23,907) and Tromsø Study 6 (2007–2008, n = 12,981). Data were collected using questionnaires including food frequency questions, non-fasting blood samples, and physical examinations. MetS was defined using the Joint Interim Societies (JIS) definition, in which one point was given for each MetS criteria fulfilled (metabolic score). Longitudinal analyses were performed using Linear mixed models. Results: For both genders, lean fish consumption once a week or more was significantly associated with decreased future metabolic score, decreased triglycerides, and increased high-density lipoprotein (HDL)-cholesterol, whereas decreased waist circumference and blood pressure was identified only for men (age adjusted models). Fatty fish consumption was significantly associated with increased waist circumference for both genders and increased HDL-cholesterol levels in men. Conclusion: The results suggest that fatty and lean fish consumption may influence MetS differently and that lean fish consumption in particular seems to be associated with beneficial changes in the MetS components.
The Impact of Shiftwork on Skeletal Muscle Health
Authors: Aisbett Brad , Condo Dominique , Zacharewicz Evelyn , Lamon Séverine
Published: March 2017

(1) Background: About one in four workers undertake shift rosters that fall outside the traditional 7 a.m.–6 p.m. scheduling. Shiftwork alters workers’ exposure to natural and artificial light, sleep patterns, and feeding patterns. When compared to the rest of the working population, shiftworkers are at a greater risk of developing metabolic impairments over time. One fundamental component of metabolic health is skeletal muscle, the largest organ in the body. However, cause-and-effect relationships between shiftwork and skeletal muscle health have not been established; (2) Methods: A critical review of the literature was completed using online databases and reference lists; (3) Results: We propose a conceptual model drawing relationships between typical shiftwork consequences; altered light exposure, sleep patterns, and food and beverage consumption, and drivers of skeletal muscle health—protein intake, resistance training, and hormone release. At present, there is no study investigating the direct effect of shiftwork on skeletal muscle health. Instead, research findings showing that acute consequences of shiftwork negatively influence skeletal muscle homeostasis support the validity of our model; (4) Conclusion: Further research is required to test the potential relationships identified in our review, particularly in shiftwork populations. Part of this testing could include skeletal muscle specific interventions such as targeted protein intake and/or resistance-training.
Monitoring Moisture Damage Propagation in GFRP Composites Using Carbon Nanoparticles
Authors: Al-Sabagh Ahmed , Taha Eman , Kandil Usama , Awadallah Ahmed , Nasr Gamal-abdelnaser , Reda Taha Mahmoud
Published: March 2017

Glass fiber reinforced polymer (GFRP) composites are widely used in infrastructure applications including water structures due to their relatively high durability, high strength to weight ratio, and non-corrosiveness. Here we demonstrate the potential use of carbon nanoparticles dispersed during GFRP composite fabrication to reduce water absorption of GFRP and to enable monitoring of moisture damage propagation in GFRP composites. GFRP coupons incorporating 2.0 wt % carbon nanofibers (CNFs) and 2.0 wt % multi-wall carbon nanotubes (MWCNTs) were fabricated in order to study the effect of moisture damage on mechanical properties of GFRP. Water absorption tests were carried out by immersing the GFRP coupons in a seawater bath at two temperatures for a time period of three months. Effects of water immersion on the mechanical properties and glass transition temperature of GFRP were investigated. Furthermore, moisture damage in GFRP was monitored by measuring the electrical conductivity of the GFRP coupons. It was shown that carbon nanoparticles can provide a means of self-sensing that enables the monitoring of moisture damage in GFRP. Despite the success of the proposed technique, it might not be able to efficiently describe moisture damage propagation in GFRP beyond a specific threshold because of the relatively high electrical conductivity of seawater. Microstructural investigations using Fourier Transform Infrared (FTIR) explained the significance of seawater immersion time and temperature on the different levels of moisture damage in GFRP.
A Data-Driven Assessment of Biosphere-Atmosphere Interaction Impact on Seasonal Cycle Patterns of XCO2 Using GOSAT and MODIS Observations
Authors: He Zhonghua , Zeng Zhao-Cheng , Lei Liping , Bie Nian , Yang Shaoyuan
Published: March 2017

Using measurements of the column-averaged CO2 dry air mole fraction (XCO2) from GOSAT and biosphere parameters, including normalized difference vegetation index (NDVI), enhanced vegetation index (EVI), leaf area index (LAI), gross primary production (GPP), and land surface temperature (LST) from MODIS, this study proposes a data-driven approach to assess the impacts of terrestrial biosphere activities on the seasonal cycle pattern of XCO2. A unique global land mapping dataset of XCO2 with a resolution of 1° by 1° in space, and three days in time, from June 2009 to May 2014, which facilitates the assessment at a fine scale, is first produced from GOSAT XCO2 retrievals. We then conduct a statistical fitting method to obtain the global map of seasonal cycle amplitudes (SCA) of XCO2 and NDVI, and implement correlation analyses of seasonal variation between XCO2 and the vegetation parameters. As a result, the spatial distribution of XCO2 SCA decreases globally with latitude from north to south, which is in good agreement with that of simulated XCO2 from CarbonTracker. The spatial pattern of XCO2 SCA corresponds well to the vegetation seasonal activity revealed by NDVI, with a strong correlation coefficient of 0.74 in the northern hemisphere (NH). Some hotspots in the subtropical areas, including Northern India (with SCA of 8.68 ± 0.49 ppm on average) and Central Africa (with SCA of 8.33 ± 0.25 ppm on average), shown by satellite measurements, but missed by model simulations, demonstrate the advantage of satellites in observing the biosphere–atmosphere interactions at local scales. Results from correlation analyses between XCO2 and NDVI, EVI, LAI, or GPP show a consistent spatial distribution, and NDVI and EVI have stronger negative correlations over all latitudes. This may suggest that NDVI and EVI can be better vegetation parameters in characterizing the seasonal variations of XCO2 and its driving terrestrial biosphere activities. We, furthermore, present the global distribution of phase lags of XCO2 compared to NDVI in seasonal variation, which, to our knowledge, is the first such map derived from a completely data-driven approach using satellite observations. The impact of retrieval error of GOSAT data on the mapping data, especially over high-latitude areas, is further discussed. Results from this study provide reference for better understanding the distribution of the strength of carbon sink by terrestrial ecosystems and utilizing remote sensing data in assessing the impact of biosphere–atmosphere interactions on the seasonal cycle pattern of atmospheric CO2 columns.
An Assessment of Iterative Reconstruction Methods for Sparse Ultrasound Imaging
Authors: Valente Solivan , Zibetti Marcelo , Pipa Daniel , Maia Joaquim , Schneider Fabio
Published: March 2017

Ultrasonic image reconstruction using inverse problems has recently appeared as an alternative to enhance ultrasound imaging over beamforming methods. This approach depends on the accuracy of the acquisition model used to represent transducers, reflectivity, and medium physics. Iterative methods, well known in general sparse signal reconstruction, are also suited for imaging. In this paper, a discrete acquisition model is assessed by solving a linear system of equations by an ℓ 1 -regularized least-squares minimization, where the solution sparsity may be adjusted as desired. The paper surveys 11 variants of four well-known algorithms for sparse reconstruction, and assesses their optimization parameters with the goal of finding the best approach for iterative ultrasound imaging. The strategy for the model evaluation consists of using two distinct datasets. We first generate data from a synthetic phantom that mimics real targets inside a professional ultrasound phantom device. This dataset is contaminated with Gaussian noise with an estimated SNR, and all methods are assessed by their resulting images and performances. The model and methods are then assessed with real data collected by a research ultrasound platform when scanning the same phantom device, and results are compared with beamforming. A distinct real dataset is finally used to further validate the proposed modeling. Although high computational effort is required by iterative methods, results show that the discrete model may lead to images closer to ground-truth than traditional beamforming. However, computing capabilities of current platforms need to evolve before frame rates currently delivered by ultrasound equipments are achievable.
High Resolution Turntable Radar Imaging via Two Dimensional Deconvolution with Matrix Completion
Authors: Lu Xinfei , Xia Jie , Yin Zhiping , Chen Weidong
Published: March 2017

Resolution is the bottleneck for the application of radar imaging, which is limited by the bandwidth for the range dimension and synthetic aperture for the cross-range dimension. The demand for high azimuth resolution inevitably results in a large amount of cross-range samplings, which always need a large number of transmit-receive channels or a long observation time. Compressive sensing (CS)-based methods could be used to reduce the samples, but suffer from the difficulty of designing the measurement matrix, and they are not robust enough in practical application. In this paper, based on the two-dimensional (2D) convolution model of the echo after matched filter (MF), we propose a novel 2D deconvolution algorithm for turntable radar to improve the radar imaging resolution. Additionally, in order to reduce the cross-range samples, we introduce a new matrix completion (MC) algorithm based on the hyperbolic tangent constraint to improve the performance of MC with undersampled data. Besides, we present a new way of echo matrix reconstruction for the situation that only partial cross-range data are observed and some columns of the echo matrix are missing. The new matrix has a better low rank property and needs just one operation of MC for all of the missing elements compared to the existing ways. Numerical simulations and experiments are carried out to demonstrate the effectiveness of the proposed method.
Testing a Firefly-Inspired Synchronization Algorithm in a Complex Wireless Sensor Network
Authors: Hao Chuangbo , Song Ping , Yang Cheng , Liu Xiongjun
Published: March 2017

Data acquisition is the foundation of soft sensor and data fusion. Distributed data acquisition and its synchronization are the important technologies to ensure the accuracy of soft sensors. As a research topic in bionic science, the firefly-inspired algorithm has attracted widespread attention as a new synchronization method. Aiming at reducing the design difficulty of firefly-inspired synchronization algorithms for Wireless Sensor Networks (WSNs) with complex topologies, this paper presents a firefly-inspired synchronization algorithm based on a multiscale discrete phase model that can optimize the performance tradeoff between the network scalability and synchronization capability in a complex wireless sensor network. The synchronization process can be regarded as a Markov state transition, which ensures the stability of this algorithm. Compared with the Miroll and Steven model and Reachback Firefly Algorithm, the proposed algorithm obtains better stability and performance. Finally, its practicality has been experimentally confirmed using 30 nodes in a real multi-hop topology with low quality links.
Comparative “from Cradle to Gate” Life Cycle Assessments of Hot Mix Asphalt (HMA) Materials
Authors: Moretti Laura , Mandrone Vittorio , D’Andrea Antonio , Caro Silvia
Published: March 2017

The objective of this work is to compare the environmental impact of two different hot mix asphalt (HMA) materials used for road construction in Italy. The analyses used a “from cradle to gate” Life Cycle Assessment (LCA) boundary system and the methodology included considerations about raw materials and fuel supply, as well as transport and manufacturing processes. Primary data provided by the producers and secondary data available in the literature were used as part of the analyses. The results suggest that the proposed method offers rigorous criteria for a comprehensive assessment of the environmental impact of HMA materials, which could be used, among others, as an evaluation parameter in public bids.
Evaluation of Sulfide Control by Air-Injection in Sewer Force Mains: Field and Laboratory Study
Authors: García Juan , Vigueras-Rodriguez Antonio , Castillo Luis , Carrillo José
Published: March 2017

Chemical and biological processes consume dissolved oxygen (DO) in urban wastewater during transportation along sewer systems. Anaerobic conditions (DO < 0.2 mg/L) are easily reached, leading to sulfide (S2−) generation. Release of free sulfide, hydrogen sulfide gas (H2S), from the liquid to the gaseous phase, causes odor, corrosion of pipes and supposes a risk for health of people working in sewers. These issues get worse in force mains, due to inability to take oxygen from the gaseous phase of pipe. Air injection is a suggested practice to control H2S emission in force mains. That technique aims to keep aerobic conditions in wastewater in order to avoid sulfide generation and favor a decrease of Biochemical Organic Demand (BOD). However, several force mains with air injection are not achieving their goals due to a limited oxygen transfer. Field measurements of dissolved oxygen in urban wastewater are presented in an existing force main with air injection during the summer of 2014 in the southeast of Spain. A laboratory scale model is constructed to quantify two-phase flow conditions in pipe due to air injection for different incoming flows rates of water and air. Particularly, for the case of plug flow, also known as elongated bubble flow. Velocity field measurement of water phase in laboratory allows estimating turbulent diffusivity of oxygen in the water, Em, and inter-phase mass transfer coefficient KL(T). In the laboratory, flow and air depth, bubble length, water velocity field, pressure inside force main and water and airflow rates are determined experimentally. These variables are used to assess DO in water phase of force main by comparison with those obtained from field measurements. This work allows assessing air injection efficiency in wastewater, and, therefore, to predict DO in wastewater in force mains.
Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H
Authors: Yao Guorui , Lam Kwok-ho , Perry Kay , Weisemann Jasmin , Rummel Andreas , Jin Rongsheng
Published: March 2017

Botulinum neurotoxins (BoNTs), which have been exploited as cosmetics and muscle-disorder treatment medicines for decades, are well known for their extreme neurotoxicity to humans. They pose a potential bioterrorism threat because they cause botulism, a flaccid muscular paralysis-associated disease that requires immediate antitoxin treatment and intensive care over a long period of time. In addition to the existing seven established BoNT serotypes (BoNT/A–G), a new mosaic toxin type termed BoNT/HA (aka type FA or H) was reported recently. Sequence analyses indicate that the receptor-binding domain (HC) of BoNT/HA is ~84% identical to that of BoNT/A1. However, BoNT/HA responds differently to some potent BoNT/A-neutralizing antibodies (e.g., CR2) that target the HC. Therefore, it raises a serious concern as to whether BoNT/HA poses a new threat to our biosecurity. In this study, we report the first high-resolution crystal structure of BoNT/HA-HC at 1.8 Å. Sequence and structure analyses reveal that BoNT/HA and BoNT/A1 are different regarding their binding to cell-surface receptors including both polysialoganglioside (PSG) and synaptic vesicle glycoprotein 2 (SV2). Furthermore, the new structure also provides explanations for the ~540-fold decreased affinity of antibody CR2 towards BoNT/HA compared to BoNT/A1. Taken together, these new findings advance our understanding of the structure and function of this newly identified toxin at the molecular level, and pave the way for the future development of more effective countermeasures.
Virus Resistance Is Not Costly in a Marine Alga Evolving under Multiple Environmental Stressors
Authors: Heath Sarah , Knox Kirsten , Vale Pedro , Collins Sinead
Published: March 2017

Viruses are important evolutionary drivers of host ecology and evolution. The marine picoplankton Ostreococcus tauri has three known resistance types that arise in response to infection with the Phycodnavirus OtV5: susceptible cells (S) that lyse following viral entry and replication; resistant cells (R) that are refractory to viral entry; and resistant producers (RP) that do not all lyse but maintain some viruses within the population. To test for evolutionary costs of maintaining antiviral resistance, we examined whether O. tauri populations composed of each resistance type differed in their evolutionary responses to several environmental drivers (lower light, lower salt, lower phosphate and a changing environment) in the absence of viruses for approximately 200 generations. We did not detect a cost of resistance as measured by life-history traits (population growth rate, cell size and cell chlorophyll content) and competitive ability. Specifically, all R and RP populations remained resistant to OtV5 lysis for the entire 200-generation experiment, whereas lysis occurred in all S populations, suggesting that resistance is not costly to maintain even when direct selection for resistance was removed, or that there could be a genetic constraint preventing return to a susceptible resistance type. Following evolution, all S population densities dropped when inoculated with OtV5, but not to zero, indicating that lysis was incomplete, and that some cells may have gained a resistance mutation over the evolution experiment. These findings suggest that maintaining resistance in the absence of viruses was not costly.
Mapping Palaeohydrography in Deserts: Contribution from Space-Borne Imaging Radar
Authors: Paillou Philippe
Published: March 2017

Space-borne Synthetic Aperture Radar (SAR) has the capability to image subsurface features down to several meters in arid regions. A first demonstration of this capability was performed in the Egyptian desert during the early eighties, thanks to the first Shuttle Imaging Radar mission. Global coverage provided by recent SARs, such as the Japanese ALOS/PALSAR sensor, allowed the mapping of vast ancient hydrographic systems in Northern Africa. We present a summary of palaeohydrography results obtained using PALSAR data over large deserts such as the Sahara and the Gobi. An ancient river system was discovered in eastern Lybia, connecting in the past the Kufrah oasis to the Mediterranean Sea, and the terminal part of the Tamanrasett river was mapped in western Mauritania, ending with a large submarine canyon. In southern Mongolia, PALSAR images combined with topography analysis allowed the mapping of the ancient Ulaan Nuur lake. We finally show the potentials of future low frequency SAR sensors by comparing L-band (1.25 GHz) and P-band (435 MHz) airborne SAR acquisitions over a desert site in southern Tunisia.
Putting Flow–Ecology Relationships into Practice: A Decision-Support System to Assess Fish Community Response to Water-Management Scenarios
Authors: Cartwright Jennifer , Caldwell Casey , Nebiker Steven , Knight Rodney
Published: March 2017

This paper presents a conceptual framework to operationalize flow–ecology relationships into decision-support systems of practical use to water-resource managers, who are commonly tasked with balancing multiple competing socioeconomic and environmental priorities. We illustrate this framework with a case study, whereby fish community responses to various water-management scenarios were predicted in a partially regulated river system at a local watershed scale. This case study simulates management scenarios based on interactive effects of dam operation protocols, withdrawals for municipal water supply, effluent discharges from wastewater treatment, and inter-basin water transfers. Modeled streamflow was integrated with flow–ecology relationships relating hydrologic departure from reference conditions to fish species richness, stratified by trophic, reproductive, and habitat characteristics. Adding a hypothetical new water-withdrawal site was predicted to increase the frequency of low-flow conditions with adverse effects for several fish groups. Imposition of new reservoir release requirements was predicted to enhance flow and fish species richness immediately downstream of the reservoir, but these effects were dissipated further downstream. The framework presented here can be used to translate flow–ecology relationships into evidence-based management by developing decision-support systems for conservation of riverine biodiversity while optimizing water availability for human use.
Establishment and Application of Wetlands Ecosystem Services and Sustainable Ecological Evaluation Indicators
Authors: Chen Han-Shen
Published: March 2017

Gaomei wetlands are national Taiwanese coastal wetlands. Over the past few years, they have grown into an important water bird habitat and popular bird-watching location. However, the rapid growth in tourism has begun to affect the environmental quality in the Gaomei wetlands. This study combined ecosystem services (ES) and ecological footprint (EF) assessments to evaluate the sustainability status according to the features of each ecosystem service for the different Gaomei wetlands land uses. The results found that (a) the total Gaomei wetlands ecosystem service value increased from 59.24 million TWD in 2008 to 98.10 million TWD in 2015, and the ecosystem service function was continuously improving; (b) the EF increased by 56.12% over 8 years; and (c) there was a negative growth rate of 106.54% in the ecological deficit (ED) in the sustainable ecological evaluation indicators (SEEI). The ecological footprint index (EFI) in 2015 was at Level 4 at 1.02, and the environmental sustainability index (ESI) was at Level 3 at 0.49. Results show that Gaomei wetlands have a low sustainability; therefore, the local, regional, and national governments need to implement regulations to strictly control the Gaomei wetlands land use. This study demonstrated that ES and EF theory application can give an objective guidance to decision-makers to ensure that wetlands eco-security can be maintained at safe levels.