bluuebunny/crossref_metadata_2025 huggingface dataset:
Coexistência com a fauna no Campus USP “Luiz de Queiroz”
Authors:   Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz, Marchini Silvio , Ferraz Katia Maria Paschoaletto Micchi de Barros ,   Universidade de São Paulo. Escola Superior de Agricultura Luiz de Queiroz
Published: February 2023

Em Coexistência com a Fauna no Campus USP “Luiz de Queiroz” compartilhamos com o público uma visão ampla sobre as interações entre pessoas e fauna, com ênfase nos desafios e oportunidades de existir juntos - ou coexistir - com nossos vizinhos silvestres. Entendemos que, cada vez mais, pessoas e fauna silvestre se encontrarão em espaços verdes como o Campus USP “Luiz de Queiroz”, e também em outros mais inusitados, como as áreas urbanas e residenciais. Para coexistir é preciso mudar a forma como temos interagido com a fauna e entre nós mesmos. É sobre essa mudança que falamos neste livro. Mais especificamente, por meio das interações envolvendo 20 ícones da fauna no Campus USP “Luiz de Queiroz”, entre eles a capivara, a seriema, o sagui e a onça-parda, ilustramos os caminhos para melhorar nossas relações com a fauna, dentro e fora do campus, em benefício dos animais e de nós mesmos.
Revision of the Alycaeidae of China, Laos and Vietnam (Gastropoda: Cyclophoroidea) II: The genera Alycaeus and Pincerna
Authors: PÁLL-GERGELY BARNA
Published: February 2023

This is the second part of the revision of Chinese, Lao and Vietnamese Alycaeidae (superfamily Cyclophoroidea), and covers the genera Alycaeus and Pincerna. Three new species are described: Alycaeus goliath Páll-Gergely, n. sp. (central Laos), Pincerna acroptychia n. sp. (Ha Giang Province, northern Vietnam), Pincerna viginticostatus n. sp. (Lạng Sơn Province, northern Vietnam). Pincerna vallis Z.-Y. Chen & M. Wu, 2020 is treated as a junior synonym of Pincerna costulosus (Bavay & Dautzenberg, 1912), and Pincerna clausus D. S. Do & T. S. Nguyen, 2022 as a synonym of Pincerna vanbuensis (Bavay & Dautzenberg, 1900).
Transvaginal Resection of a Gastrointestinal Stromal Tumor (GIST) of the Rectum
Authors: Feng Winnie A. , Zeineddin Suhail , Mazraani Maurice , Del Prado Paul
Published: February 2023

Gastrointestinal stromal tumors (GISTs) are connective tissue tumors representing a minority of gastrointestinal tumors. A 49-year-old woman was found to have a rectal mass in addition to uterine fibroids during work-up for abnormal uterine bleeding. A peri-rectal mass was again seen during hysterectomy, but definitive resection was deferred. A pelvic MRI suggested a posterior vaginal wall mass. A transvaginal approach was chosen for excision of a solid multi-lobulated mass from the rectovaginal septum space. Frozen section reported uterine leiomyoma, but final pathology confirmed a 10-cm high-risk GIST arising from the rectal muscularis propria, with microscopically positive margins. Patient was started on imatinib therapy. Abdominopelvic resection was offered to decrease the risk of recurrence but was declined. Repeat imaging has shown no obvious distant metastases or residual rectovaginal region mass. The simultaneous and similar presentation of uterine leiomyoma and rectal GIST draws attention to this case.
Social Contexts, Momentary Mood and Affective Variability in Early Adolescence: An Exploratory Ecological Momentary Assessment Study
Authors: Walsh Reubs J. , van Buuren Mariët , Hollarek Miriam , Sijtsma Hester , Lee Nikki C. , Krabbendam Lydia
Published: February 2023

The frequency, intensity and variability of emotional experiences increase in early adolescence, which may be partly due to adolescents’ heightened affective sensitivity to social stimuli. While this increased variability is likely intrinsic to adolescent development, greater mood variability is nevertheless associated with the risk of internalising psychopathology. Early adolescents (N = 58, ages 13–14) reported their social context and mood when prompted by a smartphone application. Valence, arousal, and their variability were compared across social contexts using multilevel regression models. Social contexts were defined by the presence of close others, peripheral others, both, or neither. Arousal was lower when alone. Valence was lower and more variable, and arousal was more variable when alone than in either close or peripheral company. This is the first time that level and variability of valence and arousal in adolescent affect have been shown systematically to differ for the same individual in different daily-life social contexts.
Interactive Management Research in Organizational Communication
Authors: Razzante Robert J. , Hogan Michael , Broome Benjamin , Tracy Sarah J. , Chawla Devika , Skurzak Donna M.
Published: February 2023

In this research methods essay, we describe Interactive Management Research (IMR), a participatory action research methodology with extensive applications in organizational settings but new to organizational communication research. IMR offers possibilities as a participant-centered methodology that is particularly well suited for complex organizational design situations requiring a systems perspective. We detail two versions of IMR, an interview-based method (IMRi) and a group-based method (IMRg), using a case study of each method to illustrate their application to organizational communication research. We believe IMR is an approach to participatory action research that can provide unique insights into the systems thinking and communication that shapes organizations and organizing.
Finite element study of V-shaped crack-tip fields in a three-dimensional nonlinear strain-limiting elastic body
Authors: Gou Kun , Mallikarjunaiah S. M.
Published: February 2023

We study the crack-tip fields in a three-dimensional (3D) plate with a V-shaped crack employing Rajagopal’s theory of elasticity with the strain-limiting effect. The classical linear elastic fracture mechanics (LEFM) theory bears a well-documented inconsistency, i.e., for a static crack problem under the traction-free boundary condition, the LEFM theory predicts singular crack-tip strains. Such results are inconsistent with the constitutive relation derived using the assumption of uniform bound for the strain values. Instead, Rajagopal’s recent theory of elasticity provides implicit constitutive relations between the linearized strain and Cauchy stress in which one can impose an a-priori upper bound for strains. We formulate the strain-limiting theory comprehensively in this article. The linearized strain is expressed as a nonlinear function of the Cauchy stress. The equation for the equilibrium of the linear momentum under a special type of nonlinear constitutive relation reduces to a second-order quasilinear elliptic boundary value problem (BVP). Using a Picard-type linearization and a continuous Galerkin-type finite element technique, we solve several BVPs with tensile and shear displacement loading. The numerical results for the strains, the stresses, the stress intensity factor (SIF), and strain energy density (SED) are obtained for different Poisson values, strain-limiting parametric values, and the V-shaped angles. The growth of the near-tip strains is far less than that of stresses, and the results for both the SIF and SED are also consistent with the results from LEFM. Our work demonstrates that the framework of Rajagopal’s theory of elasticity can provide a basis for developing physically meaningful and mathematically well-posed BVPs to study evolution of cracks, damage, nucleation, or failure in elastic bodies.
Arterial Spin Labeling in Migraine: A Review of Migraine Categories and Mimics
Authors: Pinto Soniya N , Lerner Alexander , Phung Daniel , Barisano Giuseppe , Chou Brendon , Xu Wilson , Sheikh-Bahaei Nasim
Published: February 2023

Migraine is a complex headache characterized by changes in functional connectivity and cerebral perfusion. The perfusion changes represent a valuable domain for targeted drug therapy. Arterial spin labeling is a noncontrast imaging technique of quantifying cerebral perfusion changes in the migraine setting. In this narrative review, we will discuss the pathophysiology of the different categories of migraine, as defined by the International Classification of Headache Disorders-3 and describe a category-based approach to delineating perfusion changes in migraine on arterial spin labeling images. We will also discuss the use of arterial spin labeling to differentiate migraine from stroke and/or seizures in the adult and pediatric populations. Our systematic approach will help improve the understanding of the complicated vascular changes that occur during migraines and identify potential areas of future research.
Children’s digital play as collective family resilience in the face of the pandemic
Authors: Burke Anne , Kumpulainen Kristiina , Smith Caighlan
Published: February 2023

In this article we explore how digital play as conducted through various social media and online meeting platforms facilitated resiliency and confidence building in children during the COVID-19 pandemic. Using day-in-the-life methodology and narrative inquiry, we disseminate and examine observations collected on children aged 2-10 during lockdown in a Newfoundland neighbourhood. Children utilized platforms such as TikTok, YouTube, and Zoom to embrace their agentic digital play in ways that repurposed the platforms to fulfil life milestones and social needs otherwise impacted and disrupted by pandemic restrictions. Through a series of vignettes and interviews, our research not only examines how such digital play benefits children and their healthy development, but how parents reacted to and assisted with their children’s agentic digital platform manipulation and how this provided positive benefits and enriching experiences to the entire family. We additionally explore the conflicts and tensions both children and parents encountered in securely implementing free play via digital platforms, including fears of excess screen-time, digital dependency, and online threats, all of which risk limiting children’s ability to independently explore their creativity and identities through digital play if not handled sensitively. Despite the hurdles to implementing digital play, this study exposes why it is essential for families to navigate this online terrain; this study ultimately poses that digital play and online platforms not only were beneficial to maintaining and building family resilience during the pandemic but will be vital assets in sustaining resiliency and positive mindsets moving forward with pandemic recovery.
One year of digital contact tracing: Who was more likely to install the NHS COVID-19 app? Results from a tracker survey in England and Wales
Authors: Al-Haboubi Mustafa , Exley Josephine , Allel Kasim , Erens Bob , Mays Nicholas
Published: February 2023

Objective

To examine changes in the uptake of the National Health Service (NHS) COVID-19 proximity (contact) tracing application (‘app’) over one year, amongst smartphone users in England and Wales.

Methods

We conducted a longitudinal survey between October 2020 and September 2021, amongst an online panel representative of smartphone users aged 18–79 and a purposeful sample from six of the largest minority ethnic groups. We fitted pooled logistic regression models to examine factors associated with app installation and a longitudinal logistic regression model to estimate factors associated with installing/uninstalling the app over time.

Results

Around 50% of respondents had the app installed at each time point. The majority of installations took place soon after its launch. The key reason for installing at launch was ‘civic, public or social responsibility’. Amongst those who installed the app later, it was ‘needed to scan NHS QR code’. Uptake was higher amongst individuals who considered themselves vulnerable to COVID-19 or were concerned about the risk COVID-19 posed, were more highly educated, of White ethnicity, and who reported higher levels of trust in government information. Factors associated with installing the app over time included becoming more concerned about the risk COVID-19 poses to the country, or perceiving that the crisis in their local area had worsened.

Conclusions

Despite changes in pandemic response and case numbers, app installation in England and Wales remained relatively stable after launch. If governments wish to increase app installation and use rates in future pandemics, they need to highlight those app features that encourage engagement, and take related action to allay privacy concerns and improve trust in government information sharing.
Multidirectional Instability of Shoulder Joint: A Review
Authors: Prasetia Renaldi , Purwana Siti Zainab Bani , Rasyid Hermawan Nagar
Published: February 2023

Introduction:

The biomechanics of the shoulder joint are complex. To allow a functional range of motion, stability is sacrificed. Glenohumeral joint stability is maintained by static and dynamic stabilizers. Static stabilizers are non-contractile structures including capsulolabral structures and bony glenoid while dynamic stabilizers are contractile structures including rotator cuff, conjoint tendon, and long head of the bicep. The objective of this review is to elaborate on multidirectional instability (MDI) of the shoulder joint and the management of this disorder.

Review:

Laxity can be affected by hereditary and genetic factors. This can be seen for example in generalized joint laxity which often manifests in the shoulder as MDI. Mutations in collagen genes can cause altered collagen structure, mostly in collagen Type I, resulting in smaller and longer collagen cells. Abnormalities could be found in mRNA synthesis or amino acid transcription for collagen protein, resulting in amino acid content variation. Alterations in fine-tuning mechanism, cleavage process, ionic interaction, cross-linking and metabolism could also result in collagen quality variation. Genetic factors could also cause elastin overproduction rate or amount. Elastin amino acid content alterations could also be affected genetically. These alterations produced a looser static stabilizer. Even so, shoulder joint have multiple static stabilizers and the individual having hereditary laxity does not always have problems related to joint laxity. If the laxity caused problems, it is usually in the form of pain, discomfort, or disruption in shoulder joint function. To compensate for the loose static stabilizer, rehabilitation should be optimized on the contractile, musculature structure of the glenohumeral joint. Besides rehabilitation, capsular shift procedure could also be performed as management of the affected joint by open surgery, arthroscopic capsular plication, or arthroscopic thermal capsulorrhaphy.

Conclusion:

Based on the review conducted, reoperation rates for open surgery, arthroscopic technique, and thermal technique were approximately 10%, 5%, and 15% subsequently. This should be considered when choosing the appropriate surgery method for MDI management if rehabilitation on contractile structures does not improve patients’ condition.
The Management of Femoroacetabular Impingement
Authors: Reksoprodjo Adisa Yusuf
Published: February 2023

Management of the Femoroacetabular Impingement (FAI) starts with good diagnosis. What one must remember that the natural course of FAI is the precursor to hip osteoarthritis. An excellent history taking and physical examination is mandatory to exclude many differential diagnosis surrounding the hip. A layered approach could be used. 90 degrees of flexion and internal rotation (FADIR) is specific for hip problem, although doesn’t mean the main culprit is always FAI. Radiology study is very important, several hip projection Xray that can be chosen and specific measurement like Alpha angle, Cam or Pincer or mixed deformity, and so on. Additional imaging with CT or MR Arthrography is also important. With confirmed FAI, controversies exist whether to proceed conservatively or surgery, with nuance of the evidence depends on the background of the writer. Nowadays, surgery for FAI already pushed toward full arthroscopic, while surgical hip dislocation remains a powerful arsenal. Rehabilitation after surgery is utmost importance, and it took time for the results to show it benefits, therefore, a good communication with patient and the whole team of care is advisable.
Combined avulsion fracture of the tibial tubercle and patellar tendon rupture in young athlete: An uncommon injury
Authors: Hardjosworo Sapto Adji , Pohan Muhammad Alvin Shiddieqy
Published: February 2023

Introduction:

Patellar tendon rupture is a rare entity, accounting for 3% of all knee extension system injuries. In some cases, the tear is accompanied with avulsed tibial tubercle. Such concurrent fracture is extremely rare, and only a few previously cases have been described in the literature. We reported a 13-year-old male with combined avulsion fracture of the tibial tubercule and patellar tendon rupture.

Case Report:

A 13-year-old male junior basketball athlete presenting with left knee pain since 2 days before admission. The patient had previously fell to the ground with his left knee hitting the ground while playing basketball. Physical examination demonstrated swollen left knee. Radiographic examination suggested tibial tubercle avulsion, and magnetic resonance imaging demonstrated partial rupture of distal patellar tendon. The patient then underwent open reduction and internal fixation using single cannulated screw for the avulsed tibial tubercle, and patellar tendon reconstruction using suture anchor with ultra high molecular weight polyethylene fibers. Postoperatively, the patient was placed in a locked straight leg brace. One week after surgery, the patient began range of motion exercises and progression of weight bearing with physical therapy. At 4 months of follow-up, the patient can already weightbear, and he had regained active knee range of motion.

Discussion:

Combined avulsion fracture of the tibial tubercle and patellar tendon rupture in young athlete is an extremely rare case. As such, there is no guideline regarding the best treatment. In this report, we chose open surgery for anatomical reduction of the tuberosity fragment because we consider the growth plate and direct visualization of the patellar tendon. Rigorous physical therapy is of utmost importance in this patient for return to sport, as he is a young athlete.

Conclusions:

Open reduction and internal fixation using single cannulated screw, and patellar tendon reconstruction suture anchor might be a treatment of choice for those with combined avulsion fracture of the tibial tubercle and patellar tendon rupture in young patients.
Medial meniscal posterior root attachment repair in degenerative patient to slower the progression of knee osteoarthritis
Authors: Butar John Christian Parsaoran Butar , Pohan Muhammad Alvin Shiddieqy
Published: February 2023

Introduction:

Meniscal root tear is frequently misdiagnosed and often lead to knee osteoarthritis. Historically, such entity was often treated nonoperatively or with partial meniscectomy. We reported a case of a 78-year-female with osteoarthritis of the knee and meniscal root tear treated with transtibial double tunnel pullout technique.

Case Report:

A 78-year-old female presenting with left knee pain. One month ago, the patient fell in her bathroom. Physical examination demonstrated locking knee, positive McMurray test. Radiograph suggested osteoarthritis of the left knee Kellgren-Lawrence (KL) grade 2. Magnetic resonance imaging demonstrated traumatic medial posterior meniscal root tear. The patient then underwent meniscal root repair using transtibial double-tunnel pullout technique. Postoperatively, the patient’s knee was placed in a brace and she was kept non-weight-bearing for 6 weeks. At six months of follow-up, the patient no longer complained of pain and locking knee. The Knee Injury and Osteoarthritis Outcome Score (KOOS) also improved from 50 to 90 after six months of follow up. She could weightbear and perform daily activities.

Discussion:

Meniscal root tear is commonly underdiagnosed, and it often go unnoticed on magnetic resonance imaging and arthroscopy in large part due to the lack of anatomic understanding. Surgery is worthwhile in this case, as it may prevent osteoarthritis from getting worsen. Repairing the meniscal root with a transtibial pullout repair may restore contact pressures to those of the intact states and allow for the dispersion of hoop stresses across the meniscus. In this report, the patient had satisfactory outcome at 6 months of follow-up, where she no longer felt pain and locking knee.

Conclusions:

Transtibial double-tunnel pullout technique may be treatment of choice for those with meniscal root tear and may provide the greatest improvement in function and lowest risk of conversion to Total Knee Arthroplasty. Further clinical studies are required to investigate the comparative benefit of the transtibial repair technique.
Isolated Medial Patellofemoral Ligament Reconstruction for the Treatment of Recurrent Lateral Patellar Dislocations: A Systematic Review and Meta-Analysis
Authors: Aryana I Gusti Ngurah Wien , Prayudi Ida Bagus Deny
Published: February 2023

Introduction:

Being one of the most common acute knee disorders In children and adolescents, the incidence of patellar dislocations among pediatric patients is estimated to 43 per 100,000 with peak of age at 15 years.1 Briefly, a nonoperative treatment have been considered as the standard of care for patellar dislocations.5 However, recurrent patellar instability, osteochondral fractures with loose bodies, and failed non operative measures of functional rehabilitation benefitted from surgical treatment.6 As for the purpose of return-to-sports after surgery, clinicians have been using the utilization of time, ROM, strength, and subjective measures as guidelines.2,10

Methods:

The population size was harvested from each study as well as means/medians and ranges for population age and follow-up time. Recurrent instability were taken to note, preoperative and postoperative Tegner for estimated return to play, positive apprehension test and Kujala scores were extracted. he study calculate means for population size, age, postoperative Tegner scores.

Results:

The total mean population size of all 6 studies was 217 participants, with a mean age and follow-up of 23.5 years and 30.8 months, respectively. The data extracted from all studies included in the review, as well as all calculated means, are presented in Table 3. The total mean population size of all 6 studies was 217 participants, with a mean age and follow-up of 23.5 years and 30.8 months, respectively.

Conclusion:

The mean postoperative Tegner score was 5.7, calculated from 4 studies. Preinjury and preoperative Tegner scores were reported in only one study. The pooled proportion of athletes who returned to sports after surgery was 84.1% (95% CI, 71.1%– 97.1%) (Figure 1). The pooled estimated mean from 7 studies that reported means ± SDs for the postoperative Kujala score was 85.8 (95% CI, 81.6–90.0; I2 = 92%) (Figure 2). Also, 4 studies reported the frequency at which patients exhibited a positive apprehension sign during follow-up; the pooled risk from these studies was 3.6% (95% CI, 0%–7.2%) (Figure 3). The pooled total risk of recurrent instability after surgery was 1.2% (95% CI, 0.3%–2.1%; I2 = 0%)
Superior Peroneal Retinaculum Reconstruction For Traumatic Peroneus Longus Subluxation: A Case report
Authors: Febriana Andini , Aryana IGN Wien
Published: February 2023

Background:

Peroneal tendon subluxation is a rare condition that often misdiagnosed, generally associated with sport related injury. Subluxation of the peroneal tendons is uncommon and is frequently misinterpreted as an ankle sprain, usually in young and active patients. The most common pathological mechanism is a dorsiflexory and mostly caused by avulsion of the superior peroneal retinaculum (SPR) from its fibular insertion. Treatment may be conservative or surgical, although there is no agreement on the best technique to use.

Case Report:

A 35-year-old man presented with pain and swelling of the lateral side of the left foot after play badminton. The patient felt pain upon palpation and snapping sign during flexion–extension of the left ankle. The patient was treated with conservative treatment for 1 month with no improvement, and we recommended to do surgical treatment for relieved the pain.

Discussion:

Superior Peroneal Retinaculum Reconstruction shows an great result; after the procedure, there are no significant side effects such infections, wound issues, or ongoing discomfort. The surgical outcome was viewed as satisfactory overall. Following surgery, the ankle was put in a semi-equinus position for two weeks while being immobilized with a non-weight-bearing, temporary below-knee cast.

Conclusion:

Acute peroneus longus subluxation might be difficult to diagnose since it is usually misinterpreted as an ankle sprain. The occurrence of peroneal tendon subluxation is rather low, and surgery is the main treatment for this injury. If conservative treatment shows no improvement, variety of surgical techniques are available. Several literature reported superior peroneal retinaculum reconstruction has satisfactory outcome.
Characteristics of Supracondylar Humeral Fracture in Pediatric Patients at Hasan Sadikin General Hospital in January 2012 - January 2022
Authors: Setiawanto Teguh
Published: February 2023

Introduction:

Supracondylar humerus fracture is one of most common fracture in children, more than 50% of elbow fracture and one-third of limb fracture. This research evaluate Supracondylar fracture characteristics at hasan sadikin hospital in January 2012 – January 2022.

Method:

This is a descriptive study, data obtained from medical records, Supracondylar humerus fracture who were treated at Hasan Sadikin Hospital in January 2012-January 2022. The data is age, gender, length of stay, open/closed fracture, first aid, complications, and fresh/delayed cases.

Result:

The age group with the highest incidence is children 8-9 years old, 33 patients (48.5%) were BPJS members and Supracondylar humerus commonly occurred in boys, 41 patients were boys (85.41%), and the majority of the case was closed fractures, 46 patients were closed fracture (95.83%), 2 patient were open fractures (4.17%), 3 patients went to bone setter prior to hospital admission (6.2%), 4 patient was neglected fractures, and 1 patient had nerve palsy (median and radial nerve palsy), 45 fresh fracture (93.8%), and 3 patients (6,2%) were delayed in receiving medical treatment.

Discussion:

Our results showed similar results on gender, bone setter as first aid, but different results on age group, complications, and delayed treatment with the study conducted by farhan et al in 2018. This study showed that the highest incidence rate is 8-9 years old (48.5%) vs ¬1-4 and 5-9 years old (34.6%), boys are common 85.41% vs 61.5%. About 6.2% vs 7.69% of patients went to bone setter prior to the hospital, Complications found in the studies showed 8.33% neglected fractures vs 11.5% cubitovarus deformity, 2.08% vs 0% had nerve palsy, and 6.2% vs 36.12% patients were delayed in receiving medical treatment. This study evaluated data from 2012, the number of BPJS members is not a majority (48.5%), because BPJS programs were enrolled in 2014.

Conclusion:

The Boys, 8-9 years age group is the group most at risk of humeral supracondylar fractures, the majority of supracondylar humerus fractures were closed whom treated with LOS was 7-8 days.
Neglected Quadriceps Rupture Managed with Polypropylene Mesh and Collacure: A Case Report
Authors: Haryono Adriel Benedict , Utoyo Ghuna Arioharjo
Published: February 2023

Background:

Quadriceps muscle rupture is second common cause of disrupted extensor mechanism by directly affect lower limb function by hinders knee extension drastically. Ideally, patient with quadriceps tendon rupture and undergo primary surgical repair in first 48–72 hours after injury to achieve good outcome then decrease morbidity and disability. Chronic untreated quadriceps tendon rupture with adverse progression of gap cause by muscle contraction, scarred muscle body, degenerative calcification, or decreased tendon end vascularity lead to pain in contraction, worsening morbidity and disability as well makes surgical repair more technically challenging. We report one case of chronic untreated quadriceps muscle rupture, our management, and outcomes.

Clinical case:

27 years old male with right quadriceps rupture that occurred accidently while he was descending stairs. The patient then went to bonesetter and just went to the hospital after a long time of complaints of pain and are not getting better. In the right knee, the neglected quadriceps rupture was managed with polypropylene mesh and collacure to shorthen the gap.

Discussion:

Management goal is to reduce large gap at quadriceps tendon to reach both end of the muscle in tension free manner and not only increasing regeneration of tendon but also increasing the strength of the tissues after healing by polypropylene mesh and collacure.

Conclusion:

Quadriceps reconstruction with polypropylene mesh and collacure have a fair result for extensor mechanism. Further research is required to determine best approach to quadriceps reconstruction in reducing gap.
A Case Series of Successful Lateral Extra-articular Tenodesis (LET) in ACL Reconstruction
Authors: Ramadhani Rahadiansyah , Lubis Andri MT
Published: February 2023

Introduction:

In the United States, 80.000-100.000 Anterior Cruciate Ligament (ACL) injury repairs are performed annually. Recent development added lateral extra-articular tenodesis (LET) to improve the outcome of ACL reconstruction. This research evaluates the outcome of LET in ACL injury based on our experiences evaluated in effectiveness and complication.

Methods:

This case series included three patients diagnosed with ACL rupture in Cipto Mangunkusumo General Hospital from January to February 2022. All patients underwent ACL reconstruction followed by LET.

Results:

In our studies, all of our cases underwent surgery with successful clinical outcomes. In addition, all patients in our studies also reported no complications postoperatively.

Conclusion:

The addition of LET in ACL reconstruction was found to be successful with no complications. Further application of the method is endorsed to bring more benefits with less risk of side effects or failure. Follow-up should be done to observe the long-term effects of the method.
Return to Sport After Arthroscopic Capsular Repair in Elite Baseball Players
Authors: Uffmann William J. , ElAttrache Neal S. , Youssefzadeh Keon , Carbone Andrew , Limpisvasti Orr
Published: February 2023

Background:

Chronic attritional midsubstance capsular tears arising from repetitive throwing stress are a rare but important source of pain and dysfunction in elite baseball players; however, little is known regarding outcomes after arthroscopic capsular repair.

Purpose:

To evaluate the patient-reported outcomes and return-to-sport (RTS) rates after arthroscopic capsular repair in elite baseball players.

Study Design:

Case series; Level of evidence, 4.

Methods:

We identified 11 elite-level baseball players who were treated with arthroscopic repair for a midsubstance glenohumeral capsular tear by a single surgeon with a uniform approach and a standardized postoperative protocol between 2012 and 2019. All players had at least 2 years of follow-up data. Demographic data and concomitant surgical procedures were recorded. Preoperative and postoperative Kerlan-Jobe Orthopaedic Clinic (KJOC) scores and Single Assessment Numeric Evaluation (SANE) scores were collected in a subset of the cohort, and statistical comparisons were made. A telephone survey was conducted to determine the patients’ RTS level and outcome scores. Statistical comparisons between preoperative and postoperative outcomes scores were made using t tests.

Results:

Eight major league players, 1 minor league player, and 2 collegiate players were included. There were 9 pitchers, 1 catcher, and 1 outfielder. All patients had debridement of the posterosuperior labrum and rotator cuff. Two pitchers underwent a rotator cuff repair, and 1 outfielder underwent a posterior labral repair. The mean age at the time of surgery was 26.9 years (range, 20-34 years), with a mean follow-up of 3.5 years (range, 2.6-5.9 years). There were significant preoperative versus postoperative improvements in the mean KJOC (20.6 vs 89.8; P = .0002) and SANE (28.3 vs 86.7; P = .001) scores. All patients reported a high degree of satisfaction. At a mean of 16.3 months (range, 6.5-25.4 months), 10 of 11 (90.1%) players met the Conway-Jobe good or excellent criteria for RTS.

Conclusion:

Arthroscopic capsular repair provided significant improvements in functional outcomes in elite baseball players, high levels of patient satisfaction, and high levels of RTS.
Modulation of defense genes and phenolic compounds in wild blueberry in response to Botrytis cinerea under field conditions
Authors: Abbey Joel , Jose Sherin , Percival David , Jaakola Laura , Asiedu Samuel K.
Published: February 2023

Botrytis blight is an important disease of wild blueberry [(Vaccinium angustifolium (Va) and V. myrtilloides (Vm))] with variable symptoms in the field due to differences in susceptibility among blueberry phenotypes. Representative blueberry plants of varying phenotypes were inoculated with spores of B. cinerea. The relative expression of pathogenesis-related genes (PR3, PR4), flavonoid biosynthesis genes, and estimation of the concentration of ten phenolic compounds between uninoculated and inoculated samples at different time points were analyzed. Representative plants of six phenotypes (brown stem Va, green stem Va, Va f. nigrum, tall, medium, and short stems of Vm) were collected and studied using qRT-PCR. The expression of targeted genes indicated a response of inoculated plants to B. cinerea at either 12, 24, 48 or 96 h post inoculation (hpi). The maximum expression of PR3 occurred at 24 hpi in all the phenotypes except Va f. nigrum and tall stem Vm. Maximum expression of both PR genes occurred at 12 hpi in Va f. nigrum. Chalcone synthase, flavonol synthase and anthocyanin synthase were suppressed at 12 hpi followed by an upregulation at 24 hpi. The expression of flavonoid pathway genes was phenotype-specific with their regulation patterns showing temporal differences among the phenotypes. Phenolic compound accumulation was temporally regulated at different post-inoculation time points. M-coumaric acid and kaempferol-3-glucoside are the compounds that were increased with B. cinerea inoculation. Results from this study suggest that the expression of PR and flavonoid genes, and the accumulation of phenolic compounds associated with B. cinerea infection could be phenotype specific. This study may provide a starting point for understanding and determining the mechanisms governing the wild blueberry-B. cinerea pathosystem.
Using ethnographic approaches to document, evaluate, and facilitate virtual community-engaged implementation research
Authors: Rabin Borsika A. , Cain Kelli L. , Salgin Linda , Watson Paul L. , Oswald William , Kaiser Bonnie N. , Ayers Lawrence , Yi Crystal , Alegre Alexander , Ni Jessica , Reyes Allyn , Yu Kasey E. , Broyles Shelia L. , Tukey Robert , Laurent Louise C. , Stadnick Nicole A.
Published: February 2023

Background

Community Advisory Boards (CABs) have been frequently used to engage diverse partners to inform research projects. Yet, evaluating the quality of engagement has not been routine. We describe a multi-method ethnographic approach documenting and assessing partner engagement in two “virtual” CABs, for which we conducted all meetings remotely.

Methods

Two research projects for increasing equitable COVID-19 testing, vaccination, and clinical trial participation for underserved communities involved remote CAB meetings. Thirty-three partners representing 17 community groups participated in 15 sessions across the two CABs facilitated by a social change organization. We developed ethnographic documentation forms to assess multiple aspects of CAB member engagement (e.g., time spent speaking, modality used, types of interactions). Documenters were trained to observe CAB sub-groups via virtual sessions. Debriefing with the documentation team after CAB meetings supported quality assurance and process refinement. CAB members completed a brief validated survey after each meeting to assess the quality and frequency of engagement. Content and rapid thematic analysis were used to analyze documentation data. Quantitative data were summarized as frequencies and means. Qualitative and quantitative findings were triangulated.

Results

A total of 4,540 interactions were identified across 15 meetings. The most frequent interaction was providing information (44%), followed by responding (37–38%). The quality and frequency of stakeholder engagement were rated favorably (average 4.7 of 5). Most CAB members (96%) reported good/excellent engagement. Specific comments included appreciation for the diversity of perspectives represented by the CAB members and suggestions for improved live interpretation. Debriefing sessions led to several methodological refinements for the documentation process and forms.

Conclusion

We highlight key strategies for documenting and assessing community engagement. Our methods allowed for rich ethnographic data collection that refined our work with community partners. We recommend ongoing trainings, including debriefing sessions and routinely reviewed assessment of data to strengthen meaningful community engagement.
Improving adolescent health literacy through school-based health literacy intervention: a mixed-method study protocol
Authors: Khanal Shanti Prasad , Budhathoki Chitra Bahadur , Okan Orkan
Published: February 2023

Background

Health-promoting actions might benefit from adolescent health literacy (AHL), however, there is scant research on it in Nepal. This study identifies adolescent students’ health literacy (HL) needs and trials an intervention to improve their HL and intention to take health-promoting actions.

Methods

This study employs a pre-and post-test mixed-method intervention involving three phases. First, we will conduct a formative and summative evaluation to identify participants’ HL needs and design an intervention using quantitative and qualitative methods. Second, the intervention will be administered to the intervention group. Finally, formative and summative post-tests will be conducted to assess the effectiveness of the intervention. We will select four community schools from Birendranagar municipality based on random sampling. In quantitative research, data will be collected from adolescents selected through a census with standardized scales such as the HLS-Child-Q15, self-efficacy, social support, and health-promoting actions. A framework analysis was conducted to analyze qualitative data collected from focus group discussions with purposively chosen adolescents and key informant interviews with Health and Physical Education teachers and school nurses. Thedifference in differenceapproach will be used to analyze the intervention’s outcome, i.e., the participants’ improved HL, and health-promoting actions.

Discussion

This is one of the first studies to explore HL in this group in Nepal. This study will provide the first insights into the overall level of AHL, potential AHL determinants, and the relationship between AHL and the intention to participate in health-promoting activities. The data can then be used to inform health promotion and health literacy initiatives.
Efficacy and safety of tafolecimab in Chinese patients with heterozygous familial hypercholesterolemia: a randomized, double-blind, placebo-controlled phase 3 trial (CREDIT-2)
Authors: Chai Meng , He Yongming , Zhao Wang , Han Xuebin , Zhao Guoyan , Ma Xueping , Qiao Ping , Shi Dongmei , Liu Yuyang , Han Wei , An Pei , Li Haoyu , Yan Shuling , Ma Qingyang , Deng Huan , Qian Lei , Zhou Yujie ,   on behalf of CREDIT-2 investigators
Published: February 2023

Background

Heterozygous familial hypercholesterolemia (HeFH) is largely underdiagnosed and undertreated in China where few patients achieved recommended target levels of low density lipoprotein cholesterol (LDL-C). We conducted the first randomized, placebo-controlled clinical trial in Chinese patients with HeFH to assess the efficacy and safety of tafolecimab, a novel fully human proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibody.

Methods

Patients diagnosed with HeFH by Simon Broome criteria and on a stable lipid-lowering therapy for at least 4 weeks were randomized 2:2:1:1 to receive subcutaneous tafolecimab 150 mg every 2 weeks (Q2W), tafolecimab 450 mg every 4 weeks (Q4W), placebo Q2W or placebo Q4W in the 12-week double-blind treatment period. After that, participants received open-label tafolecimab 150 mg Q2W or 450 mg Q4W for 12 weeks. The primary endpoint was the percent change from baseline to week 12 in LDL-C levels. Secondary endpoints included proportion of participants achieving ≥50% LDL-C reductions and proportion of participants with LDL-C <1.8 mmol/L at week 12 and 24, the change from baseline to week 12 in non-high density lipoprotein cholesterol (non-HDL-C), apolipoprotein B and lipoprotein(a) levels, as well as the change from baseline to week 24 in lipid levels.

Results

In total, 149 participants were randomized and 148 received at least one dose of the study treatment. At week 12, tafolecimab treatment induced significant reductions in LDL-C levels (treatment difference versus placebo [on-treatment estimand]: −57.4% [97.5% CI, −69.2 to −45.5] for 150 mg Q2W; −61.9% [−73.4 to −50.4] for 450 mg Q4W; both P <0.0001). At both dose regimens, significantly more participants treated with tafolecimab achieved ≥50% LDL-C reductions or LDL-C <1.8 mmol/L at week 12 as compared with corresponding placebo groups (all P <0.0001). Meanwhile, non-HDL-C, apolipoprotein B and lipoprotein(a) levels were significantly reduced in the tafolecimab groups at week 12. The lipid-lowering effects of tafolecimab were maintained till week 24. During the double-blind treatment period, the most commonly-reported adverse events in the tafolecimab groups included upper respiratory tract infection, increased blood creatine phosphokinase, increased alanine aminotransferase, increased aspartate aminotransferase and hypertension.

Conclusions

Tafolecimab administered either 150 mg Q2W or 450 mg Q4W yielded significant and persistent reductions in LDL-C levels and showed a favorable safety profile in Chinese patients with HeFH.

Trial registration

ClinicalTrials.gov, NCT04179669.
A novel videoscope and tool kit for percutaneous pericardial access under direct visualization
Authors: Opfermann Justin D. , Contento Jacqueline M. , Mass Paige N. , Krieger Axel , Berul Charles I. , Kumthekar Rohan N.
Published: February 2023

Background

Pericardial access is necessary for the application of epicardial cardiac therapies including ablation catheters, pacing and defibrillation leads, and left atrial appendage closure systems. Pericardial access under fluoroscopic guidance is difficult in patients without pericardial effusions and may result in coronary artery damage, ventricular injury, or perforation with potentially life-threatening pericardial bleeding in up to 10% of cases. There is a clinical need for a pericardial access technique to safely deliver epicardial cardiac therapies.

Methods

In this paper, we describe the design and evaluation of a novel videoscope and tool kit to percutaneously access the pericardial space under direct visualization. Imaging is performed by a micro-CMOS camera with an automatic gain adjustment software to prevent image saturation. Imaging quality is quantified using known optical targets, while tool performance is evaluated in pediatric insufflation and pericardial access simulators. Device safety and efficacy is demonstrated by infant porcine preclinical studies (N = 6).

Results

The videoscope has a resolution of 400 × 400 pixels, imaging rate of 30 frames per second, and fits within the lumen of a 14G needle. The tool can resolve features smaller than 39.4 µm, achieves a magnification of 24x, and has a maximum of 3.5% distortion within the field of view. Successful pericardial access was achieved in pediatric simulators and acute in vivo animal studies. During in vivo testing, it took the electrophysiologist an average of 66.83 ± 32.86 s to insert the pericardial access tool into the thoracic space and visualize the heart. After visualizing the heart, it took an average of 136.67 ± 80.63 s to access the pericardial space under direct visualization. The total time to pericardial access measured from needle insertion was 6.7 × quicker than pericardial access using alternative direct visualization techniques. There was no incidence of ventricular perforation.

Conclusions

Percutaneous pericardial access under direct visualization is a promising technique to access the pericardial space without complications in simulated and in vivo animal models.
Reducing inequities in maternal and child health in rural Guatemala through the CBIO+ approach of Curamericas: 2. Study site, design, and methods
Authors: Perry Henry B. , Valdez Mario , Blanco Stanley , Llanque Ramiro , Martin Shayanne , Lambden Jason , Gregg Corey , Leach Kaitlin , Olivas Elijah , Muffoletto Barbara , Wallace Jacqueline , Modanlo Nina , Pfeiffer Erin , Westgate Carey C. , Lesnar Breanne , Stollak Ira
Published: February 2023

Background

The Curamericas/Guatemala Maternal and Child Health Project, 2011–2015, included implementation research designed to assess the effectiveness of an approach referred to as CBIO+﻿ , composed of: (1) the Census-Based, Impact-Oriented (CBIO) Approach, (2) the Care Group Approach, and (3) the Community Birthing Center Approach. This is the second paper in a supplement of 10 articles describing the implementation research and its findings. Paper 1 describes CBIO+ , the Project Area, and how the Project was implemented.

Objective

This paper describes the implementation research design and details of how it was carried out.

Methods

We reviewed the original implementation research protocol and the methods used for all data collection related to this Project. The protocol and methods used for the implementation research related to this Project were all standard approaches to the monitoring and evaluation of child survival projects as developed by the United States Agency for International Development Child Survival and Health Grants Program (CSHGP) and the CORE Group. They underwent independent peer review supervised by the CSHGP before the implementation research began.

Results

The study area was divided into two sets of communities with a total population of 98,000 people. Project interventions were implemented in Area A from 2011 until the end of the project in 2015 (44 months) and in Area B from late 2013 until 2015 (20 months). Thus, Area B served as a quasi-comparison area during the first two years of Project implementation. The overarching study question was whether the CBIO+ Approach improved the health and well-being of children and mothers. The outcome indicators included (1) changes in population coverage of evidence-based interventions, (2) changes in childhood nutritional status, (3) changes in the mortality of children and mothers, (4) quality of care provided at Community Birthing Centers, (5) the impact of the Project on women’s empowerment and social capital, (6) stakeholder assessment of the effectiveness of the CBIO+ Approach, and (7) the potential of wider adoption of the CBIO+ Approach.

Conclusion

The implementation research protocol guided the assessment of the effectiveness of the CBIO+ Approach in improving the health and well-being of children, mothers, and their communities.