bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF CONVENTIONAL AND SHARIA STOCK PERFORMANCE BASED ON SHARPE, TREYNOR, AND JENSEN INDECES
Authors: Usama Abdullah Fikri  , Kurniawati Meylianingrum
Published: January 2025

The purpose of the research is to analyse the performance of conventional and sharia stocks in the Indonesian capital market for the 2019-2023 period. the LQ45 and JII indices are used as proxies to represent each of the conventional and sharia stocks. The method used in this research is descriptive method, where the evaluation of the performance of conventional and sharia stocks is measured based on the sharpe, treynor, and jensen indices. The population in this research are all stocks included in the LQ 45 and JII indices in the 2019-2023 period. The samples in this study were 19 conventional stocks from the LQ 45 indices and 13 Islamic stocks from the JII indices. The sampling method used is non-probability sampling with a purposive sampling approach. the results of this study show several stocks that have performed well during the 2019-2023 period, in conventional stocks, namely: ADRO, ANTM, BBRI, ICBP, INCO, ITMG. While in sharia stocks, namely ADRO, ANTM, ICBP, INCO. These stocks can be considered by investors to be included in the investment portfolio. The conclusion of this study is that the performance of conventional and sharia stocks based on the Sharpe, Treynor, and Jensen, value of stocks is dominated by negative values, which means that the condition of stock analysis is quite bad compared to the portfolio, portfolio beta, and the market or benchmark used.
ENHANCING MUSTAHIK WELFARE THROUGH ISLAMIC SOCIAL FINANCE: AN INSTITUTIONAL PERSPECTIVE
Authors: Muhammad Rusdi  , Mahmud Alfan Jamil  , Sinsin Asmy
Published: January 2025

This research aims to determine the efforts of Islamic social financing institutions in Palembang, including Baznas and LAZ, to improve the welfare of mustahiq. The key informants in this research are the leaders of Baznas and LAZ. Data analysis techniques using qualitative descriptive. Research findings show that several strategies used by Baznas in distributing zakat, infaq and alms funds to improve mustahik welfare include, meeting basic needs, economic empowerment through productive zakat, educational program scholarships, free health services, priority distribution in remote and underdeveloped areas, cooperation and partnerships with the government, Ramadan programs and community empowerment. Conclusions to improve the welfare of mustahik Baznas and LAZ provide support to Mustahiq in the form of programs and strategies in collaboration with the government
WORKSHOP GREEN TECHNOLOGY UNTUK PARA SISWA MENENGAH PERTAMA
Authors: Sugata Marcelia , Samantha Ariela , Pinontoan Reinhard , Victor Hans , Marbun Kristin Talia
Published: January 2025

Workshop mengenai aplikasi bioteknologi pada green technology untuk mengatasi pencemaran air melalui proses dekolorisasi merupakan salah satu bentuk kerja sama antara Fakultas Sains dan Teknologi (FaST) Universitas Pelita Harapan (UPH) dengan Sekolah Palembang Harapan (SPH). Tujuan kegiatan ini adalah memperkenalkan siswa Sekolah Menengah Pertama (SMP) dengan produk-produk teknologi ramah lingkungan yang sederhana. Dalam pelaksanaannya, kegiatan ini dilakukan secara onsite. Siswa SMP dari Sekolah Palembang Harapan akan memperoleh pemaparan materi melalui presentasi oleh dosen Program Studi Biologi. Dalam rangka meningkatkan minat dan ketertarikan siswa, pemberian materi dilanjutkan dengan sesi workshop sehingga para siswa dapat melakukan hands on untuk mengoperasikan alat peraga dekolorisasi. Selama kegiatan berlangsung, para siswa menunjukkan ketertarikan terhadap materi yang diberikan dengan memberikan berbagai pertanyaan, serta secara aktif berpartisipasi untuk mencoba mengoperasikan alat peraga. Setelah kegiatan para siswa diharapkan telah mendapatkan wawasan dan pemahaman mengenai berbagai produk teknologi sederhana yang ramah lingkungan.
PKM Peningkatan Kapasitas Kelompok Sadar Wisata penggerak EduWisata Hidroponik di Desa Beton, Kecamatan Menganti, Kabupaten Gresik
Authors: ASTUTI Sri juni woro , Susanto Heri , Supriyanto Supriyanto
Published: January 2025

Peran Kelompok Sadar Wisata (Pokdarwis) sangat strategis dalam pengembangan pariwisata desa, dan peningkatan perannya dapat memberikan dampak yang lebih besar terhadap keberlanjutan dan kualitas destinasi. Dengan peningkatan peran ini, Pokdarwis tidak hanya menjadi pelaku wisata pasif, tetapi juga motor penggerak utama yang berperan aktif dalam pengelolaan dan pengembangan pariwisata yang lebih profesional, berkelanjutan, dan berbasis pada pemberdayaan masyarakat lokal. Demikian pula dengan pengembangan wisata di desa beton, kabupaten Gresik yang memiliki potensi cukup baik, namun pokdarwis disana masih perlu ditingkatkan kapasitasnya melalui pelatihan, pembinaan dan pendampingan agar dapat mendorong realisasi edu wisata yang telah direncanakan. Permasalahan lain yang dihadapi Pokdarwis Dewi Kolaga sebagai mitra pkm antara lain belum adanya rencana yang matang dalam pengembangan edu wisata. Adapun program intervensi yang dilakukan oleh tim PKM adalah dengan memberikan pelatihan manajemen pariwisata berbasis eduwisata dengan mengembangkan kebun hidroponik sebagai pelengkap kolam pancing yang sudah dibangun sebelumnya. Selain itu untuk mempromosikan keberadaan eduwisata di desa Beton tersebut juga diberikan pelatihan pemasaran wisata dengan menggunakan media sosial. Hasil dari intervensi yang dilakukan menunjukkan perkembangan positif dengan adanya dukungan dari perangkat desa dan pokdarwis yang antusias dalam membangun kebun hidroponik dan mengikuti berbagai pelatihan dalam rangka penguatan kapasitas. Pendampingan akan dilakukan untuk menjamin keberlanjutan program.
Emilia Bea, Los deberes en la edad de los derechos
Authors: Greco Tommaso
Published: January 2025

Este artículo reseña: Emilia BEA, Los deberes en la edad de los derechos
David San Martín Segura, La intrusión jurídica del riesgo
Authors: Colomer Segura Ana
Published: January 2025

Este artículo reseña: David SAN MARTÍN SEGURA, La intrusión jurídica del riesgo
Integrating Collaboration and Communication Skills: Development of Discovery Learning-Based Science Module
Authors: Prahastiwi Rima Buana , Sholehah Najah
Published: January 2025

This research is a development study with the final outcome being a discovery learning-based science module as an alternative to integrate collaboration and communication learning skills. The development of the integrated science module aims to create innovative teaching materials that can be applied as an alternative for learning and support independent or student-centered learning. The integrated science module is developed based on discovery learning. The goal of discovery learning is to provide students with practice in various skills, particularly collaboration and communication skills. The development research method used is the ADDIE design development method. This method was chosen because it is a fundamental development method that is easy to apply. The stages of the ADDIE design development process include Analyze, Design, Development, Implementation, and Evaluation. The product feasibility test involved 30 students from MTs Miftahul Ma’arif Pelambik, with assessments conducted by media and content experts. The media feasibility test resulted in a score of 92.7%, categorized as very feasible. The content feasibility test resulted in a score of 96.4%, also categorized as very feasible. The student response score to the development of the integrated science module ranged from 3.7 to 3.9 out of a maximum score of 4. The results of this study imply that the module is valid and feasible for use in teaching, particularly as an alternative for collaboration and communication learning skills.
Trajectories of Light Beams in a Kerr Metric: the Influence of the Rotation of an Observer on the Shadow of a Black Hole
Authors:   Ural Mathematical Center, Udmurt State University, Bizyaev I. A.
Published: January 2025

This paper investigates the trajectories of light beams in a Kerr metric, which describes the gravitational field in the neighborhood of a rotating black hole. After reduction by cyclic coordinates, this problem reduces to analysis of a Hamiltonian system with two degrees of freedom. A bifurcation diagram is constructed and a classification is made of the types of trajectories of the system according to the values of first integrals. Relations describing the boundary of the shadow of the black hole are obtained for a stationary observer who rotates with an arbitrary angular velocity about the axis of rotation of the black hole.
“ Yüksek Teknoloji Şirketleri için Ar-Ge’nin Önemi: Dudullu Organize Sanayi Bölgesi Örneği”
Authors: Baykara Tarık , Aydın Uzun Dılan
Published: January 2025

Teknolojinin bu kadar geliştiği, internetin herkesin evlerine kadar girdiği ve hatta yapay zekanın temellerinin atıldığı günümüzde, yüksek teknoloji alanında faaliyet gösteren şirketlerin Ar-Ge çalışmaları yapmaması kaçınılmazdır. Özellikle global piyasalarda rekabet edebilmek ve edindiği yeri sağlamlaştırmak isteyen her şirket, sürekli yenilik ve gelişim üzerine kurulu bir strateji anlayışıyla organizasyonel faaliyetlerini sürdürmelidir. Bu çalışmada ülkemizin önemli bir bölgesi olan Dudullu Organize Sanayi Bölgesinden seçilmiş olan başarılı yüksek teknoloji şirketlerinin Ar-Ge alanına verdikleri önemi gözlemlemek amacıyla yapılmıştır. Çalışma dahilinde, ilk olarak Ar-Ge’nin tanımı yapılmış, ikinci bölümde ise yüksek teknoloji şirketlerinin genel kabullerine yer verilmiştir. Çalışma sonucunda, Ar-Ge çalışmalarının yenilik üretmek isteyen yüksek teknoloji şirketleri için artık vazgeçilemez bir olgu olduğu doğrulanmıştır. Günümüz şartlarında teknoloji ve hatta yüksek teknoloji alanında faaliyet gösteren bir firmanın güçlü olabilmesi ve öyle kalabilmesi için ürün, süreç ve hizmetlerin sürekli yenilik yapmaya, bu sebeple Ar-Ge çalışmaları için gereken maddi ve manevi tüm kaynaklara gerekli özen ve önemi vermesi gerekmektedir
Reconstructing Memory and Identity in Beloved by Toni Morrison: Application of Trauma Theory
Authors: Adnan Ali  , Seema  , Sameena
Published: January 2025

The main objective of this article is to explore, among other things, Morrison's work itself, with a deep examination of trauma theory and studies in memory, because it reveals just how complex the interrelationality is between historical injustices and personal suffering. The presence of slavery reverberates through the characters in Beloved (1987) by Toni Morrison, exposing the continuous impact of historical trauma on the making of individual and collective identities. This paper microscopically looks into great detail at the characters, narrative structure, and symbolic features of the novel to work out how the aftereffects of slavery impact the psychological and emotional brinks of Sethe, Paul D, and Denver. Those fragmented, often chilling memories realized in Beloved tell another broader process—one in which society comes to terms with a troubling legacy. This paper delves into how the novel represents collective memory within the underlined African American community and how storytelling functions through the double-speak of bearing witness to trauma and a pathway toward healing. Contextualizing Morrison's work within current discourse about racial injustice and trauma, this study draws light on the relevancy of Beloved, as a novel that in its time advanced social knowledge and reconciliation. The study thus paves a way for how literature on historic trauma could be engaged with to open further dialogue.
Learning English through Drama-Based Approach (DBA): A Pedagogical Stylistic Experiment with Pygmalion
Authors: Shahzadi Sarah  , Qayyum Abdul
Published: January 2025

This study explores the effectiveness of using a new approach called drama-based approach in helping to learn English language. This approach was pioneered by Dorothy Heathcote in 1950. Heathcote, a drama teacher, developed this technique to help young children communicate confidently in English. In this research, the same theatrical method is employed to enhance students' spoken English skills. The chosen medium for the dramatic activity is George Bernard Shaw's play Pygmalion (1916), focusing on selected passages relevant to English language learning. The research incorporates both qualitative and quantitative methods, demanding active participation from students in the play. They engaged by taking on various roles of characters, as opposed to being passive listeners under a teacher's direction. This research took place in Dera Ismail Khan at Government College No. 1, involving 5th semester students who were divided into two groups: a control group and an experimental group. The experimental group performed the play through role-play and dialogue reading, while the control group read the play through traditional methods without any active engagement. The experimental study unfolded in three stages: a questionnaire, an intervention combined with improvisation, and an exam. Results were statistically measured and compared across both groups. The experimental group outperformed the control group in spoken English, demonstrating that a drama-based approach effectively facilitates the students in learning English language. This method allowed students to easily grasp themes, central message, linguistic elements, and character relationships, enhancing their understanding as well as their accents. The heightened engagement and enjoyment expressed by the students indicated a positive reception of this learning activity.
An approach to the implementation of medical decision support systems based on the principles of a serviceoriented architecture using digital medical ecosystem services.
Authors:   Ailamazyan Program Systems Institute of RAS, Mikheev A. E.
Published: January 2025

Despite the potential effectiveness demonstrated in individual medical organizations, medical decision support systems (DSSMS) have not been widely used in Russia. Based on the provisions of the National Strategy for the Development of Artificial Intelligence for the period up to 2030, approved by the Decree of the President of the Russian Federation, the article formulates the goal of the national plan for the development of artificial intelligence in medicine, identifies the key factors necessary to achieve this goal, as well as tasks that need to be solved to ensure the creation and widespread implementation of effective artificial intelligence. It is proposed to use the principles of service-oriented architecture (SOA) for the implementation of DSS in the digital medical ecosystem, which should contribute to achieving the stated goal. The article describes the key features and benefits of using SOA in the medical ecosystem. A model for the deployment of
SPD in the medical ecosystem based on the principles of SOA with justification of key architectural solutions is described. As an example, the architecture of the DSS is described for assessing the patient’s health status at the outpatient stage from the point of view of services
and their management. The possibilities and disadvantages of the proposed model for the implementation of the DSS are discussed.
Support for remote interaction of a medical organization by means of portal solutions integrated with HIS.
Authors:   Federal V. A. Nasonova Research Institute of Rheumatology of Russian Academy of Medical Sciences, Kalashnikov K. S. , Trofimov I. D. ,   Federal V. A. Nasonova Research Institute of Rheumatology of Russian Academy of Medical Sciences, Khatkevich M. I. ,   Federal Ailamazyan А. К. Program Systems Institute of Russian Academy of Sciences., Khatkevich M. M. ,   Federal Ailamazyan А. К. Program Systems Institute of Russian Academy of Sciences.
Published: January 2025

Purpose. The article substantiates the increase in the volume of remote interaction leads to an increase in the efficiency of the healthcare organization, improving the quality and accessibility of medical care.
Materials and methods. A solution is proposed for information support of remote work using an architecture based on portal solutions related to the healthcare information system.
Results. The main features of the solution are described, and data from the analysis of the economic efficiency of remote work are presented.
Findings. In conclusion, the directions for further development of information support tools for a healthcare organization are proposed and listed.
A collaborative approach to enhance quality education in Foundation Phase inclusive classes in South Africa
Authors: Jama Pateka , Lunga Prosper
Published: January 2025

Teachers in South African schools have the mandate to work together with parents to implement the inclusive education policy. However, schools and families continue to work as separate entities, and this negatively affects the support provided to learners experiencing barriers to learning. Insufficient collaboration between teachers and parents has hampered the ability to support learners who experience barriers to learning. Barriers to learning must be identified, and learners must receive collective support as early as in the Foundation Phase so that barriers do not continue to affect learners’ learning. Notably, there is minimal support for such learners in disadvantaged schools due to limited collaboration among support stakeholders. This study investigated how a collaborative approach can be useful to enhance effectiveness in teaching Foundation Phase inclusive classes. The study was underpinned by Ubuntu theory. Purposive sampling was used to select participants, and qualitative research methodology based on an interpretive paradigm was used. Focus group interviews, involving the recording of the discussion, were used to generate data. The findings of the thematic analysis revealed the importance of collaboration among teachers, parents, and other stakeholders to achieve and enhance effective inclusive teaching in the Foundation Phase. We conclude that locally available assets that reside in parents within the school environment should be used to promote inclusive teaching and learning.
The Impact of UNESCO MGIEP Digital Teacher Training on Nigerian Educators' Digital Pedagogy Competence and Confidence
Authors: Olurinola Oluwakemi , Olugbade Damola
Published: January 2025

This study explores Nigerian educators’ perceptions of digital pedagogy competence and the impact of a UNESCO MGIEP digital teacher training course. The study employs a validated survey and paired sample t-tests to assess the efficacy of a 5-week intervention delivered through synchronous and asynchronous modes. The findings reveal statistically significant improvements in educators' digital pedagogy competence and confidence across multiple domains following Digital Teacher Training, with substantial increases in mean scores from pre-test to post-test (p < .001) and moderate to large effect sizes (Cohen's d ranging from 0.430 to 1.062). These results demonstrate the intervention's efficacy in enhancing educators' proficiency in leveraging digital technologies for instruction, assessment, and student engagement, although a marginal decline was observed in facilitating student self-monitoring through digital means.
Teacher strategies for reducing Mathematics anxiety among secondary school students in Tanzania
Authors: Kinanda Jonas , Kyaruzi Florence , Fulgence Katherine
Published: January 2025

This study explored strategies that teachers use to reduce mathematics anxiety among students in secondary schools in Tanzania. The study employed a qualitative exploratory case study design whereby data were obtained from 18 mathematics teachers and 40 students by using interviews, focus group discussions, and field observation. The data were then analysed thematically using Braun and Clarke’s (2006) thematic analysis model. Different dominant factors that contribute to mathematics anxiety among students were found to be poor mathematics background, teachers’ aggressiveness as well as the nature of mathematics as a difficult subject. Also, it was found that teachers can use various strategies to reduce mathematics anxiety among students which include teachers’ self-control, the use of rewards and reinforcement, and engaging students in teaching. Although teachers play a crucial role in reducing students’ mathematics anxiety, it is recommended that conjoint efforts should be made by several educational stakeholders to overcome the problem.
Investigating the effect of subject specialisations, academic performance, and gender on pre-service teachers’ nature of science beliefs
Authors: Ngwenya Nkosinathi
Published: January 2025

The study sought to understand how students’ subject specialisations, academic achievements and gender influence the belief about nature of science (NOS) they hold at the end of their four year Bachelor of Education (B.Ed) degree programme in South Africa. The study was underpinned by an epistemological development theory. It was a quantitative study which involved one hundred and seventeen fourth-year students registered for a four-year Bachelor of Education degree, of whom 72 were females and 45 were males. The study revealed the following: (i) Most fourth year pre-service students were neither naïve nor sophisticated in their conception of NOS beliefs when they exited the programme. Students NOS beliefs also differed with respect to whether they were female or males. Overall, female students were slightly more sophisticated in their NOS beliefs than their male counterparts. (ii) The study also revealed that specialising in Physical Science, Life Sciences, and Technology had no effect on NOS beliefs held by both male and female students. (iii) However, male students specialising in Mathematics were found to hold more sophisticated NOS beliefs and these beliefs were significantly superior to their female counterparts. (iv) Students who academically performed at a distinction level had significantly superior NOS beliefs than those whose academic performance was just at a pass level. (v) Female students specialising in Physical Science had superior beliefs about how scientific knowledge is generated.
A tiresome but rewarding task: Teachers’ experiences of assessment within the Uganda Lower Secondary Curriculum
Authors: Ahabwe Monica
Published: January 2025

The Lower Secondary Curriculum (LSC) in Uganda, launched in February 2020, is a competence-based curriculum that has informed the shift in assessment from a focus on knowledge to competences, including the emphasis on formative rather than summative assessment. Despite efforts by Government of Uganda through the National Curriculum Development Centre (NCDC) to equip teachers with competencies to facilitate assessment under the LSC, there are observations that teachers still have limited knowledge about assessment. Moreover, little is known about how teachers cope with the new assessment modalities. This qualitative study thus explored teachers’ experiences of assessment while using the LSC. It was guided by two research questions: What are the teachers’ experiences of using the Uganda LSC assessment modalities, and how would teachers want to be supported to optimize assessment while using the Uganda LSC assessment modalities?
Influence of school type on senior secondary school physics students’ learning difficulties and misconceptions about electricity in Ondo West Local Government, Ondo State, Nigeria
Authors: Adeduyigbe Adeniyi Michael , Ukoh Edidiong E. , Okeke Uchenna Kingsley
Published: January 2025

This study investigates the influence of school type on senior secondary school physics students' learning difficulties and misconceptions regarding electricity in Ondo West Local Government, Ondo State, Nigeria. Employing a descriptive survey research design, data were collected from 300 students across 20 schools, equally divided between public and private institutions, using the Simple Electric Circuit Diagnostic Test (SECDT). The findings reveal that misconceptions about electricity are widespread, with significant percentages of students struggling with fundamental concepts such as current flow and circuit arrangement. Notably, the analysis indicates that school type significantly affects students' difficulties with electricity concepts, as those in private schools exhibited higher difficulty mean scores compared to their public school counterparts. These insights highlight the need for targeted educational interventions that address misconceptions and leverage culturally relevant teaching methods to improve physics education outcomes. The study underscores the importance of understanding the educational context to enhance teaching practices and bridge gaps in students' comprehension of critical scientific concepts.
Comparación de la resistencia adhesiva a la microtensión de dos cementos resinosos TheraCem y RelyX U200 sobre dentina bovina. Estudio in vitro
Authors:   , Cueto Pascual Katherine Stefany
Published: January 2025

Introducción: En el área de rehabilitación oral, los agentes de cementación empleados para unir restauraciones indirectas a sustratos dentales han experimentado una evolución constante para optimizar sus propiedades. Sin embargo, respondiendo a la necesidad del clínico de simplificar los pasos y agilizar el procedimiento, se introdujeron los cementos resinosos autoadhesivos que no requieren de ninguna preparación de la superficie. Objetivo: Evaluar la resistencia adhesiva a la microtensión en las superficies dentinarias de incisivos bovinos sobre dos cementos resinosos autoadhesivos. Métodos: Se extrajeron incisivos bovinos (n=8). Además, se elaboraron 8 discos de resina de laboratorio (Nexco–Ivoclar) de 8 x 2 mm. Los discos se cementaron sobre las superficies dentinarias de los incisivos bovinos previamente desgastados y se dividieron en dos grupos (Relyx U200 y TheraCem). Tras el almacenamiento (24 h / 37 °C) se seccionaron con una máquina de corte tipo IsoMet obteniendo barras de 1mm x 1 mm x 8 mm. Resultados: Se encontraron diferencias significativas desde el punto de vista estadístico al contrastar ambos grupos (p<0,05), a través del análisis U de Mann Whitney. Para el grupo de Relyx U200 se obtuvo una media de 7.46 Mpa (±,80) y para el grupo de TheraCem una media de 2.28 Mpa (± ,28). Conclusiones: El tipo de cemento resinoso autoadhesivo influye en la resistencia adhesiva a la microtensión sobre la dentina bovina, presentando un mejor comportamiento mecánico el grupo de Relyx U200.
Influencia de las características demográficas y clínico epidemiológicas en la mortalidad de los pacientes que inician hemodiálisis crónica en el Hospital Nacional Dos de Mayo durante el año 2016 hasta el año 2019
Authors:   , Silva Rodriguez Varyn Adriana , Huillca Fuentes Diego Areos
Published: January 2025

Objetivo. Determinar si características demográficas y clínico-epidemiológicas influyen en la mortalidad de los pacientes que ingresaron por primera vez a hemodiálisis crónica en el Hospital Nacional Dos de Mayo. Materiales y métodos. Estudio observacional, analítico y transversal. Se extrajeron datos demográficos, clínicos y laboratoriales de las historias clínicas de pacientes que ingresaron a hemodiálisis entre el 2016 y 2019. Pruebas estadísticas: Chi cuadrado, T de Student y U de Mann-Whitney para el análisis bivariado; para el análisis multivariado regresión logística binaria; con valor p<0,05 como significativo y un nivel de confianza del 95%. Resultados. Ingresaron a hemodiálisis crónica 487 pacientes; 56,88% varones; la media de edad fue 56,40±15,32 años; 49,28% tuvo instrucción secundaria. La etiología más frecuente (40,45%) fue la enfermedad renal diabética, el motivo de ingreso más común la sobrecarga hídrica (29,48%) y el 72,89% ingresaron por emergencia. En el análisis bivariado la mayor edad, grado de instrucción, menor tiempo entre el diagnóstico de la ERC y el inicio de HD, menor estadía hospitalaria, menor número de hemodiálisis; una menor TGO y bicarbonato y el aumento de creatinina y urea séricos estuvieron asociadas a mortalidad intrahospitalaria de manera significativa. En el análisis multivariado el incremento de urea(OR=1,011,IC(1-1,02),p=0.03) estaría asociado a una mayor probabilidad de fallecer y creatinina(OR=0,786,IC(0,64-0,95),p=0,014) a una menor probabilidad de fallecer . Conclusiones. Los pacientes que ingresaron a terapia de HD crónica en el HNDM en un periodo de 4 años, lo hicieron con una enfermedad avanzada, complicada y descompensada; un desenlace mortal se debió usualmente a un cuadro infeccioso y se asoció a un peor estado clínico al ingreso.
Determinación de la prevalencia, carga parasitaria y fauna de estrongilos en caballos de sistemas de crianza semi-intensiva del distrito de Aucallama, Huaral
Authors:   , Miranda Belleza Almendra Yadira
Published: January 2025

La crianza semi-intensiva de caballos constituye una actividad pecuaria importante para un gran sector de la población en el Perú, ya que genera un ingreso económico significativo para el productor. Sin embargo, los cuidados sanitarios que se les brindan a estos animales suelen ser bastante precarios especialmente por parte de productores de bajos recursos económicos, debido, principalmente, a la falta de conocimiento sobre el control de enfermedades, como por ejemplo las enfermedades parasitarias. Las parasitosis gastrointestinales constituyen unos de los problemas sanitarios más frecuente en equinos de crianza semi-intensiva, resaltando la presencia de los estróngilos (grandes y pequeños ó ciatostómidos). El primer paso para diseñar un óptimo programa de control para este tipo de parásitos es el de caracterizar la fauna y carga parasitaria, para determinar la estrategia de dosificación antihelmíntica más adecuada. Por ello, el objetivo de esta investigación fue determinar la prevalencia, carga parasitaria y fauna de estróngilos en caballos de crianza semi-intensiva del distrito de Aucallama - Huaral, Perú. Para ello, se tomaron muestras de heces, directamente del recto, en 86 caballos. Se utilizó la Técnica modificada de McMaster para determinar la presencia de huevos tipo Strongylus (HTS) y determinar el número de huevos por gramo de heces (hpg). También se realizaron coprocultivos para obtener larvas infectivas (L3) y así diferenciar entre grandes y ciatostómidos. La prevalencia general de HTS hallada fue de 75.6% (IC 95%: 74.7 -76.5%), siendo la carga parasitaria promedio de 42.6 hpg. Los resultados de coprocultivo indicaron que el 100% de larvas L3 pertenecieron a ciatostómidos (pequeños estróngilos). En conclusión, los caballos del Distrito de Aucallama presentan una alta prevalencia de ciatostómidos, constituyéndose como la principal parasitosis.
Exploring Factors Influencing Physical Activity Behaviours among Middle-Aged Adults in Johor Bahru, Malaysia: A Mixed-Methods Approach
Authors: Kaur Jasveen , Nambiar Nisha
Published: January 2025

This study aims to explore the factors influencing physical activity behaviours among middle-aged individuals in Johor Bahru, Malaysia, through a mixed-methods approach. Qualitative data were collected using structured surveys administered to a representative sample of 384 participants. Focus group discussions (FGDs) were conducted to explore participants' experiences and attitudes towards physical activity. Thematic analysis revealed that family support and community resources were significant facilitators of physical activity in this demographic. Regression analysis revealed age, socioeconomic status, and family support were significant predictors for physical activity levels. The study demonstrates that addressing specific barriers, such as work-related time constraints and lack of motivation, while leveraging facilitators like family support or community resources, can enhance physical activity and improve health outcomes in this population. Tailoring interventions to address the identified barriers and promote the facilitators can lead to more effective strategies for increasing physical activity, ultimately contributing to better public health outcomes.
Genome-wide identification of silencers and their regulatory mechanism in gene transcription in Arabidopsis
Authors: Chen Mao-Sheng , Yan Xiaohao , Niu Longjian , Li Xinxin , Fu Qiantang , Tang Mingyong , Wei Chi , Hou Chunhui
Published: January 2025

Gene transcription regulation is essential for eukaryotic development. Despite the considerable advances has been made in cis-regulatory elements, the roles of silencers in gene transcription, particularly in plants, remain largely elusive. Here, we employed a method called repressive self-transcribing active regulatory region sequencing (REST-seq) to systematically identify silencers across the Arabidopsis genome, modified from the STARR-seq for enhancer identification. In all, 13,032 silencers were identified from two distinct developmental stages of leaves, of which approximately 69.3% (74.6%) are located in the promoter and 3′–untranslated region (3’–UTR) regions. Genes overlapping with silencers exhibited higher expression levels than those without silencers, and the occurrence of silencers in the TES regions was positively correlated with the expression levels of proximal genes. Almost all acetylation modifications, H3K4me3, chromatin accessibility sites, as well as numerous transcription factor binding sites (TFBSs), were significantly enriched in the flanking regions of silencers, whereas they were deleted in the body regions. Numerous histone modifications and TFBSs have opposite distributional characteristics around silencers and enhancers, suggesting that they play opposing roles in controlling gene transcription. In static cases, silencers and enhancers might directly participate in proximal gene transcription rather than through distal chromatin contact loops. In dynamic cases, however, the enrichment patterns of silencers and enhancers in differentially expressed genes (DEGs) are reversed, and they govern DEG transcription through both proximal involvement and distal chromatin contact loops. Silencers and enhancers cooperatively regulate gene transcription to maintain an optimal transcript abundance of targeted genes during the development of Arabidopsis leaves. In addition, silencer activity was validated using the transgenic Arabidopsis, and several silencers displayed evident enhancer activity and strong tissue-specificity, implying that these elements may exhibit bifunctional activity in different tissues and spatiotemporal conditions. This study provided a reliable method for genome-wide silencer identification and demonstrated the roles of silencers and enhancers in the regulation of gene transcription, which will facilitate the elucidation of the regulatory mechanisms governing gene transcription in Arabidopsis.
Effect of perioperative probiotic intervention on postoperative cognitive dysfunction in elderly patients: A randomized double- blinded and placebo-controlled trial
Authors: gao sunan , dai hongyu , hao qian , song jiale , ji kang , xu hongwie , chen gang , lu jian
Published: January 2025

Background: Postoperative cognitive dysfunction (POCD) may last for days, months or even years, leading to prolonged hospitalization and increased costs, increased mortality, and poor quality of life. Although POCD is an important clinical problem, its prevention, treatment strategies and effects are still limited.
Objective: This study aims to investigate the preventive effect of perioperative probiotic intervention on POCD in elderly patients, and further explore the mechanism of probiotics in improving postoperative cognitive function.
Methods: After obtaining ethical approval and written informed consent, 190 patients aged 65 years or older scheduled for elective lower-extremity orthopedic surgery were enrolled in this randomized, double-blind trial. Enrolled patients were randomized to probiotic or control groups receiving either probiotics or placebo (210mg×4/dose, 2 times/day) from 1 day before surgery to 5 days after surgery. The primary outcome was the cognitive function assessed by Mini-mental State Examination (MMSE) on admission, the first day, the third day and the seventh day after surgery. The secondary outcomes included perioperative changes in plasma IL-1b, IL-6 and BDNF, postoperative pain intensity, perioperative activities of daily living (ADL), faecal microbiota composition and changes of intestinal metabolites
Results: The incidence of POCD in the probiotic group was significantly lower than in the control group (6 of 90 patients [6.7%] vs. 16 of 93 patients [17.2%], P=0.028). In addition, the plasma levels of proinflammatory cytokines IL-1β and IL-6 were significantly lower and BDNF levels were significantly higher in the probiotic group than in the control group 1-2 days after surgery (U=173.0, P<0.01; U=139.0, P<0.01; U=207.0, P<0.01).
Conclusion: Perioperative probiotic intervention can reduce the incidence of POCD in elderly patients, which may improve cognitive function by inhibiting inflammatory response after anesthesia and surgery, andaltering the composition of the postoperative gut microbiota and intestinal metabolites.
Microemulsion Depressurization and Increasing Injection Technology for Tight Reservoirs
Authors: Wu Yuhang , Wang Li , He Siqi , Gu Yujie , Chen Hong , Huang Wei
Published: January 2025

Although some microcracks or large cracks occur during fracturing in the tight reservoirs, the average permeability and porosity of the reservoir matrix are relatively low: 0.76×10− 3 µm2 and 11.5%, respectively. These values are typical of a typical low-permeability tight reservoir. Currently, the water injection pressure during the development of reservoir water injection is high and exceeds the reopening pressure of a crack. The pressure is close to the formation fracture pressure, which minimizes the phenomenon of water breakthrough and water injection efficiency. The reservoir matrix is substantially under injection. Therefore, a method to reduce the injection pressure and improve the matrix injection capacity is urgently needed. According to the features of tight reservoirs and crude oil, three kinds of microemulsion are screened: 13% AP6 + 4% polyoxyvinyl ether surfactant + 4% sodium petroleum sulfonate + 4% lower alcohol + 6% oil phase + 69% salt solution and 0.5% anti-temperature agent. The maximum soluble capacity of onsite oil is 14%. Microemulsion has excellent temperature resistance; if it is heated for 24 hours at 70°C, it does not break. Microemulsion also has excellent salt and anti-dilution performance. No turbidity occurs after the microemulsion and the formation water are mixed in any proportion for 24 hours. A core displacement experiment using microemulsion was performed in a lab. The results of the research indicate that the water injection pressure is reduced to a minimum of 40% when the injection concentration of the microemulsion is 1% and the injection slug is 5 PV.
OrganPipe: An automated tool to facilitate the assembly, annotation, and curation of mitochondrial and chloroplast genomes
Authors: Moreira-Oliveira† Renato R. , Silva† Bruno Marques , Molina Michele , Oliveira-Lima Marx , Leão Tiago Ferreira , Vasconcelos Santelmo , Nunes Gisele Lopes
Published: January 2025

Analyzing organellar genomes (plastomes and mitogenomes) is important for understanding evolution, cellular function, and genetic diversity. Their stable mutation rates and inheritance patterns make them valuable for phylogenetic studies and taxonomic delimitation approaches. Assembling organellar genomes is considerably more straightforward than nuclear genomes due to their smaller size and simpler structure. To that end, existing tools like NOVOPlasty, GetOrganelle, and MitoHifi can handle different sequencing data types but have limitations, such as the reliance on single k-mers or reference genomes, which leads to suboptimal results and requires manual adjustments of parameters. OrganPipe, a newly developed pipeline, overcomes these challenges by allowing iterative assembly and annotation using multiple seeds and k-mers combinations. To demonstrate its capabilities, OrganPipe was used to assemble and annotate the first mitogenomes of two invertebrate species and the plastomes of two plant species, successfully circularizing and annotating the genomes with high accuracy, besides identifying key genomic features and correcting errors missed by other tools. Accessible to beginners and non-bioinformaticians, OrganPipe empowers diverse users to perform high-quality organelle genome analyses, supporting comprehensive exploration and efficient curation. This versatile tool advances large-scale genomic studies with its user-friendly and efficient design and is accessible at https://github.com/itvgenomics/OrganPipe.

†joint first authors
A learning-driven algorithm for maintenance team and UAV collaboration in restoring power network
Authors: Pan Tiejun , Zheng Leina , Xu Ying , Zhang Xuefeng , Zhong Caiming , Wang Zhang
Published: January 2025

Power networks are highly vulnerable to disruptions caused by natural and man-made disasters, necessitating prompt restoration of damaged power supply. This research addresses the challenge of efficiently restoring large-scale power networks, which often involve numerous unknown or uninspected faulty nodes. Leveraging advancements in unmanned aerial vehicles (UAVs) technology, this study facilitates the inspection of these nodes and subsequent manual maintenance. However, coordinating maintenance teams and UAVs is complex due to the intricate network structure and scheduling correlations. We propose a learning-driven (LD) algorithm to enhance human-UAV collaboration for effective power network restoration. The algorithm includes an initialization method to generate promising initial solutions, followed by the use of search operators as basic action elements and a learning engine to guide search directions based on state assessments. Comprehensive experiments validate the algorithm’s effectiveness in improving the restoration process.
Structural and Geophysical Modeling in an area with non-outcropping Copper Sulphide Deposits, Minas Do Seival Region, Sul-Riograndense Shield, Southern Brazil
Authors: Araujo Ana Flávia , Moreira César Augusto , Alves Luiza Lima , Ilha Lenon Melo , Kumaira Sissa , Masquelin Henri , Duz Beatriz Guzzo
Published: January 2025

This paper is based on the use of indirect investigation methods using geophysics as a tool for the search for non-outcropping deposits. The integration of the geophysical methods of DC Resistivity and Induced Polarization added to the analysis of structural data is adopted in the region of Minas do Seival, in the extreme south of Brazil, in an area with no signs of surface mineralization. The region is located in the context of the Sul-Riograndense Shield, with andesites, dacites and latites occur locally, in addition tuffs, lapilli tuffs and breccia tuffs, gathered in the Hilário Formation (Neoproterozoic). The structural survey was carried out at the Barita Mine, in outcropping lapilli tuffs where brecciation, argilization and carbonation were recognized in mineralized zones, with malachite and azurite. Next, 6 electrical tomography lines with 420m of length. The combined analysis of the 2D and 3D models allows the recognition of potentially mineralized zones characterized by high chargeability. The results indicate the existence of a deposit from 30m deep with a tendency to connect the mines, partly related to silicification processes (high chargeability + high resistivity) and partly related to argilization and propylitization (high chargeability + low resistivity), structurally controlled.
The entanglement amid the multi-national geopolitical risk: Evidence from the dynamic network analysis
Authors: Cui Mingwei , Cheng Ralph , Ning Tao , Jin Ming , Zhu Gehui
Published: January 2025

The entanglement among multinational geopolitical risks is crucial for understanding the complexities and interdependencies of global politics and economies and among multinational geopolitical risks (GRP) offers valuable insights into the complexities and interdependencies of global affairs. It enhances our understanding of transmission channels, systemic vulnerabilities, power dynamics, contagion effects, risk management strategies and international legal rules. geographical connections play a significant role in influencing how countries' geopolitical risks are related to each other. However, simply being geographically close is not enough to explain these relationships. Various factors like international trade, historical correlations,legal tradition and military alliances also contribute to these connections. The passage highlights that entities such as governments, institutional investors, and multinational corporations are highly concerned about the impact of geopolitical risks. To aid them in managing the effects of geopolitical events, the constructed GPR network serves as a useful point of reference.
The moderating role of depressive symptoms in the relationship between sleep duration and psychological resilience among Chinese old adults with multiple chronic conditions
Authors: Gao Lunan , Zhao Sen
Published: January 2025

Objective: Many researches showed that psychological resilience was associated with sleep duration and depressive symptoms among the elderly. But the mechanisms underlying the relationship among old adults with multiple chronic conditions (MCC) remain unclear. This cross-sectional study aimed to explore the relationship among sleep duration, depression and psychological resilience among old adults with MCC in China and further explore the mediating role of depression between sleep duration and psychological resilience.
Methods: This study included 2339 older adults with MCC from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Participants completed questionnaires that assessed sleep duration, depression and psychological resilience. We used SPSS Process 4.0 to investigate the relationship between sleep duration, depression and psychological resilience, adjusting for a range of potential covariates and a bootstrapping sample test to examine the potential moderating role of psychological resilience in these relationships.
Results: Mean psychological resilience score was (15.60 ± 2.33) (range: 5-25). Sleep duration (r = 0.129, P < 0.01) and depressive symptoms (r = -0.547, P < 0.01) were significantly related with psychological resilience. Mediation analysis showed that depressive symptoms played a partially mediating role between sleep duration and psychological resilience, with the indirect effect of 0.114 (95% CI: 0.037-0.194), accounting for 28.29% of the variance in the relationship between sleep duration and psychological resilience.
Conclusions: Impaired sleep duration appears to accelerate depression in the elderly with MCC. Sleep duration and psychological resilience were found to be significantly positively correlated among Chinese old adults with MCC. This association was partially mediated by depressive symptoms.