bluuebunny/crossref_metadata_2025 huggingface dataset:
Automation in Interior Space Planning: Utilizing Conditional Generative Adversarial Network Models to Create Furniture Layouts
Authors: Tanasra Hanan , Rott Shaham Tamar , Michaeli Tomer , Austern Guy , Barath Shany
Published: July 2023

In interior space planning, the furnishing stage usually entails manual iterative processes, including meeting design objectives, incorporating professional input, and optimizing design performance. Machine learning has the potential to automate and improve interior design processes while maintaining creativity and quality. The aim of this study was to develop a furnishing method that leverages machine learning as a means for enhancing design processes. A secondary aim was to develop a set of evaluation metrics for assessing the quality of the results generated from such methods, enabling comparisons between the performance of different models. To achieve these aims, floor plans were tagged and assembled into a comprehensive dataset that was then employed for training and evaluating three conditional generative adversarial network models (pix2pix, BicycleGAN, and SPADE) to generate furniture layouts within given room boundaries. Post-processing methods for improving the generated results were also developed. Finally, evaluation criteria that combine measures of architectural design with standard computer vision parameters were devised. Visual architectural analyses of the results confirm that the generated rooms adhere to accepted architectural standards. The numerical results indicate that BicycleGAN outperformed the two other models. Moreover, the overall results demonstrate a machine-learning workflow that can be used to augment existing interior design processes.
The Analysis and Application of Installation Tolerances in Prefabricated Construction Based on the Dimensional Chain Theory
Authors: Long Hao , Luo Xiaoyong , Liu Jinhong , Dong Shuang
Published: July 2023

During the installation process of prefabricated components, deviations in dimensions and installation positions can occur due to construction quality issues, and the accumulation of these deviations can impact the reliability of component installation. However, the current approach to addressing accumulated deviations in the component installation process primarily relies on the trial-and-error method, lacking a solid theoretical foundation. This paper introduces the dimensional chain theory derived from mechanical engineering and presents a method to evaluate the installation reliability of prefabricated components in concrete structures. First, based on extensive measurements of installation deviations, it was found that the installation deviations of components followed a log-normal distribution. By analyzing the relationship between installation deviations and the acceptance rate, it was determined that for a 90% acceptance rate, the installation position deviation should be 8.6 mm for prefabricated wall panel components and 7.3 mm for prefabricated column components. Subsequently, the concept of dimensional chain theory from mechanical engineering was introduced to establish a limit state equation for quantifying the installation reliability of prefabricated components in concrete structures. By applying this theory, appropriate component fabrication dimensions could be determined to achieve a 95% level of installation reliability. Finally, by using the Monte Carlo method to solve the installation limit state equation for an actual engineering project, recommended fabrication dimensions for the components were obtained. The results indicate that within the horizontal axis, the length deviation of prefabricated beams, and the width fabrication dimension of columns needed to be reduced by 2.3 mm to 2.9 mm. Within the vertical axis, the length dimension of columns and the height dimension of beams had to be reduced by 0.9 mm to 2.2 mm to achieve a 95% level of installation reliability.
Numerical Modeling of Lyapunov Exponents for Structural Damage Identification
Authors: Barbosa Gustavo Botelho , Fernandes William Luiz , Greco Marcelo , Peixoto Daniel Henrique Nunes
Published: July 2023

The main purpose of this article is to discuss the use of the Lyapunov exponents to evaluate the integrity of structures. The use of such coefficients is examined in an analysis that considers the geometric and physical nonlinearities, aiming to ensure the applicability of the method in robust simulations. The material nonlinearity is modeled using the multilinear isotropic elastoplastic model together with a recently developed damage model. The nonlinear equilibrium equations solution is obtained using the positional finite element method. The Newmark time-marching procedure is implemented to evaluate the Lyapunov coefficients and a nonlinear predictor technique that needs a single data series is employed. A numerical example of a frame structure is presented to illustrate the methodology applicability. Its results show that the Lyapunov exponents can be used as indicative parameters of structural integrity, since its analysis was able to detect the occurrence of the destabilization of the structure with the dynamic jump and the presence of material failures. The non-linear predictor proved to be an efficient technique for obtaining the Lyapunov exponents, with a low computational cost. The methodology presented to monitor structural integrity was shown to be a promising alternative.
Experimental Study on the Effectiveness of Water Mist Extinguishing Systems for Protecting Paintings in Art Gallery Museums: Developing an Initial Methodological Model
Authors: Berardi Davide , Galuppi Marta , Lombardi Mara
Published: July 2023

Determining the input parameters for the calibration of a water mist extinguishing system in a compartment is important for the evaluation of the performance of the design. Although there is a lot of research on the use of water mist, it is still difficult understand the behavior of the system in terms of safety of people and protection of things. In this study, we aimed to conduct an experimental analysis to evaluate the effectiveness of water mist extinguishing systems in protecting paintings in art gallery museums. We compared onsite tests in a compartment of an art gallery and a numerical analysis carried out with Fire Dynamics Simulator (FDS). Numerical analysis using FDS included the water-cooling effect and the heat power in the simulated environment and the calibration for a model was found by reproducing the onsite results. The temperature trend was monitored as an essential parameter for the protection of the paintings. The study aimed to not only verify the effectiveness of the water mist system but also investigate the reproducibility of real-scale conditions through a simulated environment. The most important result obtained is the possibility of using a simulated environment instead of real-scale tests in order to test water mist capabilities.
Structural and Environmental Safety Studies of the Holy Mosque Area Using CFD
Authors: Farouk Mohamed
Published: July 2023

A three-dimensional (3D) CFD model was developed, covering a square area of 3.64 km2 and comprising the Holy Mosque near its center, the actual terrain, and the main surrounding buildings. The gust wind effects on the existing cranes and the collapsed tower crane in 2015, the comfort of the pedestrians, and the air quality were studied for the first time in this area. The air quality was related to calm speed, accelerating the spreading of infectious diseases. The wind comfort levels were achieved in all selected locations. The wind speeds are generally low in the area. However, gusting wind currents appeared from limited directions, causing increments in wind speeds up to 30% and causing the tower crane to collapse. Therefore, finalizing work on some cranes is recommended soon, lowering the crane boom and stopping working on windy days or changing their places. The air quality in some sites may be relatively poor, such as at the lower terraces level. New tall buildings surrounding the mosque from the north and the east are not recommended unless studying their impacts on the air quality. Pruning north and east mounts can remarkably improve natural ventilation. Large-scale fans are another solution after a detailed simulation study.
How to Guarantee the Sustainable Operation and Maintenance of Urban Utility Tunnels? From the Perspective of Stakeholder and the Whole Life Cycle
Authors: Cao Yan , Gong Zhiqi , Li Na , Wang Qiuyu
Published: July 2023

Urban utility tunnels (UUTs) have become an important infrastructure for sustainable urban development. However, numerous uncertainties brought by the complex stakeholder groups seriously hinder sustainable operation and maintenance (O&M) of UUT projects, which make it necessary to plan the development of UUT projects in advance. Previous studies mostly identified and analyzed the influencing factors from the partial life cycle perspective and neglected the limitations of exploring the complex whole life cycle factors from one single perspective. This paper comprehensively considered the perspectives of stakeholder roles and the whole UUT project life cycle and proposed a factor identification and analysis framework. In the factor identification section: (a) literature surveys were conducted to identify all influencing factors of stakeholders at each stage; and (b) 21 types of factors were identified through semi-structured interviews. In the factor analysis section: (a) the hierarchical structure of the factors was analyzed by introducing the Decision-Making Trial and Evaluation Laboratory (DEMATEL) approach and Interpretative Structural Model (ISM); (b) the various factors were divided into linkage, dependent, autonomous, and driving factors to clarify their influence degrees; and (c) the core influencing factor was determined based on the above analysis results and the two perspectives. The results indicated that (1) the pricing and charging mechanism is the decisive factor affecting the sustainable O&M of UUTs, the government should focus on establishing a standardized and transparent pricing and charging mechanism; (2) policy support to encourage social capital and user participation should be actively explored; and (3) UUT development must rely on the strong promotion of the government, and the needs of all stakeholders throughout the life cycle should be paid attention to. This study can provide useful insights for guaranteeing the sustainable O&M of UUTs in China and similar regions.
Perceptions of Canadian Radiation Oncologists, Medical Physicists, and Radiation Trainees about the Feasibility and Need of Boron Neutron Capture Therapy (BNCT) in Canada: A National Survey
Authors: Al-Bader Al-Retage , Agapito John , Pan Ming
Published: July 2023

Background: Boron Neutron Capture Therapy (BNCT) is an emerging radiotherapy. There are ongoing efforts to develop a Canadian accelerator-based BNCT center. However, it remains unclear how Canadian radiation oncologists (RO), medical physicists (MP), and their trainees perceive BNCT and its impact on radiation oncology as a discipline. Methods: A survey was created to explore the knowledge of BNCT, its clinical role, and the support for Canadian research. It was distributed through the Canadian Association of Radiation Oncology (CARO) and the Canadian Organization of Medical Physicists (COMP). Results: We received 118 valid responses from all 10 provinces, from 70 RO (59.3%) and 48 MP (40.7%), including 9 residents. Most knew of BNCT and its indications (60.2%). Although many were unaware of the reasons behind early failures (44.1%), common reasons were a lack of clinical trials and an inaccessibility of neutron sources (42.4%) as well as reactor unsuitability (34.7%). Additionally, 90.6% showed definite (66.9%) or possible (23.7%) support for Canadian BNCT research, while 89% indicated a definite (56.8%) or possible (32.2%) willingness for BNCT referrals. Conclusions: Most ROs and MPs supported Canadian BNCT research and would refer patients. However, limited awareness and a lack of experiences remain a challenge. Educational sessions are needed to realize this innovative cancer treatment in Canada.
Clinical Trial on the Safety and Tolerability of Personalized Cancer Vaccines Using Human Platelet Lysate-Induced Antigen-Presenting Cells
Authors: Koya Terutsugu , Yoshida Kenichi , Togi Misa , Niida Yo , Togi Sumihito , Ura Hiroki , Mizuta Shuichi , Kato Tomohisa , Yamada Sohsuke , Shibata Takeo , Liu Yi-Chang , Yuan Shyng-Shiou , Wu Deng-Chyang , Kobayashi Hirohito , Utsugisawa Taiju , Kanno Hitoshi , Shimodaira Shigetaka
Published: July 2023

Research and development of personalized cancer vaccines as precision medicine are ongoing. We predicted human leukocyte antigen (HLA)-compatible cancer antigen candidate peptides based on patient-specific cancer genomic profiles and performed a Phase I clinical trial for the safety and tolerability of cancer vaccines with human platelet lysate-induced antigen-presenting cells (HPL-APCs) from peripheral monocytes. Among the five enrolled patients, two patients completed six doses per course (2–3 × 107 cells per dose), and an interim analysis was performed based on the immune response. An immune response was detected by enzyme-linked immunosorbent spot (ELISpot) assays to HLA-A*33:03-matched KRASWT, HLA-DRB1*09:01-compliant KRASWT or G12D, or HLA-A*31:01-matched SMAD4WT, and HLA-DRB1*04:01-matched SMAD4G365D peptides in two completed cases, respectively. Moreover, SMAD4WT-specific CD8+ effector memory T cells were amplified. However, an attenuation of the acquired immune response was observed 6 months after one course of cancer vaccination as the disease progressed. This study confirmed the safety and tolerability of HPL-APCs in advanced and recurrent cancers refractory to standard therapy and is the first clinical report to demonstrate the immunoinducibility of personalized cancer vaccines using HPL-APCs. Phase II clinical trials to determine immune responses with optimized adjuvant drugs and continued administration are expected to demonstrate efficacy.
A Potential Biomarker of Dynamic Change in Peripheral CD45RA−CD27+CD127+ Central Memory T Cells for Anti-PD-1 Therapy in Patients with Esophageal Squamous Cell Carcinoma
Authors: Sakuma Mei , Mimura Kosaku , Nakajima Shotaro , Kaneta Akinao , Kikuchi Tomohiro , Nirei Azuma , Tada Takeshi , Hanayama Hiroyuki , Okayama Hirokazu , Sakamoto Wataru , Saito Motonobu , Momma Tomoyuki , Saze Zenichiro , Kono Koji
Published: July 2023

In order to develop a biomarker predicting the efficacy of treatments for patients with esophageal squamous cell carcinoma (ESCC), we evaluated the subpopulation of T cells in ESCC patients treated with chemotherapy (CT), chemoradiotherapy (CRT), and nivolumab therapy (NT). Fifty-five ESCC patients were enrolled in this study, and peripheral blood samples were collected before and after CT or CRT and during NT. Frequencies of memory, differentiated, and exhausted T cells were evaluated using flow cytometry among cStages, treatment strategies, pathological responses of CT/CRT, and during NT. The frequencies of PD-1+ or TIM-3+CD4+ T cells were significantly higher in patients with cStage IV. PD-1+CD4+ and TIM-3+CD8+ T-cell populations were significantly higher in patients treated with CRT but were not associated with treatment response. The frequencies of both CD4+ and CD8+ CD45RA−CD27+CD127+ central memory T cells (TCM) were significantly decreased during the course of NT in the progressive disease group. Taken together, the alteration in frequency of CD45RA−CD27+CD127+ TCM during NT may be a biomarker to predict its therapeutic response in ESCC patients.
Mechanisms of PARP-Inhibitor-Resistance in BRCA-Mutated Breast Cancer and New Therapeutic Approaches
Authors: Dilmac Sayra , Ozpolat Bulent
Published: July 2023

The recent success of Poly (ADP-ribose) polymerase (PARP) inhibitors has led to the approval of four different PARP inhibitors for the treatment of BRCA1/2-mutant breast and ovarian cancers. About 40–50% of BRCA1/2-mutated patients do not respond to PARP inhibitors due to a preexisting innate or intrinsic resistance; the majority of patients who initially respond to the therapy inevitably develop acquired resistance. However, subsets of patients experience a long-term response (>2 years) to treatment with PARP inhibitors. Poly (ADP-ribose) polymerase 1 (PARP1) is an enzyme that plays an important role in the recognition and repair of DNA damage. PARP inhibitors induce “synthetic lethality” in patients with tumors with a homologous-recombination-deficiency (HRD). Several molecular mechanisms have been identified as causing PARP-inhibitor-resistance. In this review, we focus on the molecular mechanisms underlying the PARP-inhibitor-resistance in BRCA-mutated breast cancer and summarize potential therapeutic strategies to overcome the resistance mechanisms.
Molten Metals and Molten Carbonates in Solid Oxide Direct Carbon Fuel Cell Anode Chamber: Liquid Metal Anode and Hybrid Direct Carbon Fuel Cells
Authors: Antolini Ermete
Published: July 2023

To enhance the contact between the electrolyte (source of O2−) and the carbon fuel in solid oxide–direct carbon fuel cells (SO-DCFCs), molten metals and molten salts were used in the anode chamber. Oxygen ions can dissolve and be transported in the molten medium to the anode three-phase boundary to reach and oxidize the carbon particles. To improve the sluggish kinetics of the electrochemical oxidation of carbon, the same molten media can act as redox mediators. Moreover, using a liquid metal/salt anode, tolerant to fuel impurities, the negative effect of carbon contaminants on cell performance is mitigated. In this work, an overview of SO-DCFCs with liquid metals, liquid carbonates, and mixed liquid metals/liquid carbonates in the anode chamber is presented and their performance was compared to that of conventional SO-DCFCs.
Toll-like Receptors as Pro-Thrombotic Drivers in Viral Infections: A Narrative Review
Authors: Panzer Benjamin , Kopp Christoph W. , Neumayer Christoph , Koppensteiner Renate , Jozkowicz Alicja , Poledniczek Michael , Gremmel Thomas , Jilma Bernd , Wadowski Patricia P.
Published: July 2023

Toll-like receptors (TLRs) have a critical role in the pathogenesis and disease course of viral infections. The induced pro-inflammatory responses result in the disturbance of the endovascular surface layer and impair vascular homeostasis. The injury of the vessel wall further promotes pro-thrombotic and pro-coagulatory processes, eventually leading to micro-vessel plugging and tissue necrosis. Moreover, TLRs have a direct role in the sensing of viruses and platelet activation. TLR-mediated upregulation of von Willebrand factor release and neutrophil, as well as macrophage extra-cellular trap formation, further contribute to (micro-) thrombotic processes during inflammation. The following review focuses on TLR signaling pathways of TLRs expressed in humans provoking pro-thrombotic responses, which determine patient outcome during viral infections, especially in those with cardiovascular diseases.
Zirconolite Matrices for the Immobilization of REE–Actinide Wastes
Authors: Yudintsev Sergey V. , Nickolsky Maximilian S. , Ojovan Michael I. , Stefanovsky Olga I. , Malkovsky Victor I. , Ulanova Amina S. , Blackburn Lewis R.
Published: July 2023

The structural and chemical properties of zirconolite (ideally CaZrTi2O7) as a host phase for separated REE–actinide-rich wastes are considered. Detailed analysis of both natural and synthetic zirconolite-structured phases confirms that a selection of zirconolite polytype structures may be obtained, determined by the provenance, crystal chemistry, and/or synthesis route. The production of zirconolite ceramic and glass–ceramic composites at an industrial scale appears most feasible by cold pressing and sintering (CPS), pressure-assisted sintering techniques such as hot isostatic pressing (HIP), or a melt crystallization route. Moreover, we discuss the synthesis of zirconolite glass ceramics by the crystallization of B–Si–Ca–Zr–Ti glasses containing actinides in conditions of increased temperatures relevant to deep borehole disposal (DBD).
Outcomes from the First European Planetary Health Hub Convening at ARTIS in Amsterdam
Authors: Kort Remco , Pivor Jeremy , Antó Josep M. , Bergsma Annemarie , Blankestijn Peter J. , Bollen Olette , van Bree Egid , Browne Joyce L. , de Bruin Judith , Buikx Jasper , Cadeddu Chiara , Cole Jennifer , Costabile Francesca , de Croon Aimée , Depoux Anneliese , Fussell Ian , Goodwin Bernhard , Groenewegen Arte , Grootjen Milo , Halonen Jaana I. , Hämäläinen Riitta-Maija , Have Pieter ten , Herrmann Martin , de Heer Pauline , van Heteren Godelieve , Janmaat Jopke , Jevtic Marija , Mulder Hans , Lambrecht Nathalie , Lionetti Vincenzo , Llamas Camilla Alay , Manten Maarten , Martens Pim , Moreno Ariadna , Müller Francine , O’Callaghan-Gordo Cristina , Muller Sara , Nyblon Cecilia Manosa , Mattijsen Juliette , Ossebaard Hans , Pijnenborg Karlien , Postma Nynke , Pörtner Lisa , Prass Marju , Rathod Lekha , Robert Alexandre , Rochfort Andrée , Roig Alexis , Schoch Anja , Schwienhorst-Stich Eva-Maria , Stappen Ralf Klemens , Stegeman Ingrid , van der Stelt Jorieke , Stenvinkel Peter , Sutorius Rembrandt , Venhof Valesca , Veenman Martine , Villani Leonardo , Voss Maike , de Vries Michiel , van der Zande Laura , Zotinca Andreea , Queralt-Bassa Arnau , Myers Samuel S.
Published: July 2023

A new network of over 72 organizations from 12 countries was activated during a convening at ARTIS in Amsterdam on 26–27 September 2022. Representatives are aligned with the transdisciplinary field and social movement of Planetary Health, which analyzes and addresses the impacts of human disruptions to natural systems on human health and all life on Earth. The new European Planetary Health Hub consists of organizations from various sectors, including universities, healthcare, youth, business, and civil society. The Convening, co-organized by the Planetary Health Alliance (PHA), the European Environment and Sustainable Development Advisory Councils Network (EEAC), and Natura Artis Magistra (ARTIS), aimed to develop Planetary Health Working Groups for Education, Policy Engagement, Research, and Movement Building. The Convening resulted in an outline for each of the Working Group’s aims, visions, missions, priorities, and activities, and set the framework for sustaining their activities in the future through the establishment of the European Planetary Health Hub Secretariat in the Netherlands. The Hub members shared lessons learned, built relationships, and developed artwork-inspired perspectives on Planetary Health. In conclusion, the Convening led to the establishment of a strong European foundation to contribute to the transformations needed for sustainable, just, and equitable societies that flourish within the limits of our ecosystems.
A Turn-On Fluorescent Assay for Glyphosate Determination Based on Polydopamine-Polyethyleneimine Copolymer via the Inner Filter Effect
Authors: Ni Pengjuan , Liu Siyuan , Lu Yizhong
Published: July 2023

The threat of glyphosate to food safety has attracted widespread attention. Consequently, it is highly urgent to develop a sensitive and accurate method for glyphosate detection. Herein, a turn-on fluorescent method for glyphosate detection using polydopamine-polyethyleneimine (PDA-PEI) copolymer as a fluorescent probe and p-nitrophenylphosphate (PNPP)/alkaline phosphatase (ALP) as a fluorescence quenching system is developed. The PDA-PEI copolymer was prepared by a one-pot method under mild condition, and its fluorescence kept almost unchanged after storing in a refrigerator for one month. ALP catalyzed the hydrolysis of PNPP to p-nitrophenol (PNP) that caused the fluorescence quenching of PDA-PEI copolymer via the inner filter effect. However, glyphosate inhibited ALP activity, thereby preventing the formation of PNP and restoring the fluorescence signal. Under the optimized conditions, the fluorescence of PDA-PEI copolymer depended on glyphosate concentrations ranging from 0.2 to 10 μg/mL with a detection limit of 0.06 μg/mL. Moreover, this assay was applied to detect glyphosate in real samples using the standard addition method. The recoveries were in the range from 88.8% to 107.0% with RSD less than 7.78%. This study provides a novel insight for glyphosate detection and expands the applications of fluorescent copolymer.
Protocatechuic Acid and Syringin from Saussurea neoserrata Nakai Attenuate Prostaglandin Production in Human Keratinocytes Exposed to Airborne Particulate Matter
Authors: Jeong Myeongguk , Ju Yeongdon , Kwon Hyeokjin , Kim Yeeun , Hyun Kyung-Yae , Choi Go-Eun
Published: July 2023

Saussurea neoserrata Nakai offers a reliable and efficient source of antioxidants that can help alleviate adverse skin reactions triggered by air pollutants. Air pollutants, such as particulate matter (PM), have the ability to infiltrate the skin and contribute to the higher occurrence of cardiovascular, cerebrovascular, and respiratory ailments. Individuals with compromised skin barriers are particularly susceptible to the impact of PM since it can be absorbed more readily through the skin. This study investigated the impact of protocatechuic acid and syringin, obtained from the n-BuOH extract of S. neoserrata Nakai, on the release of PGE2 and PGD2 induced by PM10. Additionally, it examined the gene expression of the synthesis of PGE2 and PGD2 in human keratinocytes. The findings of this research highlight the potential of utilizing safe and efficient plant-derived antioxidants in dermatological and cosmetic applications to mitigate the negative skin reactions caused by exposure to air pollution.
Alveolar Bone Preservation Using a Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin: A Study in Rats
Authors: Pascawinata Andries , Revilla Gusti , Sahputra Roni Eka , Arief Syukri
Published: July 2023

Alveolar bone resorption is a post-extraction complication wherein there is a reduction in the dimensions and quality of the alveolar bone. This study aimed to examine the effects of implantation of a combination of nanocrystalline hydroxyapatite (nHA) and injectable platelet-rich fibrin (IPRF) on the expression of tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), osteocalcin (OCN), and new bone formation. A total of 32 male rats had their upper right incisors extracted under general anesthesia and were then divided into a control group, nHA group, IPRF group, and nHA-IPRF group. Decapitation was carried out on day 14 and day 28 in each group and the jaws of each rat were subjected to immunohistochemical and histological analysis. The results showed a decrease in TRAP expression in the nHA-IPRF group compared with the control group on day 14 (p = 0.074) and day 28 (p = 0.017). The study also showed an increase in ALP and OCN in the HA-IPRF group on day 14 and day 28 compared with the control group. New bone formation suggested a significant increase in the nHA-IPRF group compared with the control group on day 14 (p = 0.001) and day 28 (p = 0.001). nHA-IPRF implantation can suppress alveolar bone resorption, which is indicated by decreased TRAP expression, and it can increase bone growth, as indicated by increased expression of ALP, OCN, and new bone formation.
Eu2+-Activated Ba0.5Sr0.5Al2O4 Phosphors for Screen Printing and Anti-Counterfeiting Flexible Film
Authors: Wu Jiao , Liu Quanxiao , Gao Peng , Hu Jiaqi , Cao Meijuan , Zhang Junying , Chen Wei , Wang Jigang , Qi Yuansheng , Li Zhenjun
Published: July 2023

Herein, a series of Ba0.5Sr0.5Al2O4: xEu2+ (x = 0.01, 0.02, 0.03, 0.04, 0.06) nanophosphors were synthesized by a combustion method. The investigation encompassed the characterization of the phase purity, morphology, elemental composition, and photoluminescence behavior of Ba0.5Sr0.5Al2O4: xEu2+ nanoparticles. Under excitation by 303 nm and 365 nm ultraviolet light, the nanoparticles exhibited blue-green emission arising from the 4f65d→4f7 transition of Eu2+ ions. The optimal doping concentration was determined to be 2%. Notably, the nanoparticles demonstrated fluorescence lifetimes and quantum yields of 1010 ns (λex = 303 nm), 112 ns (λex = 365 nm), 10.5%, and 10.3%, respectively. Additionally, a comprehensive analysis of the band structure and electronic density of states was conducted, revealing a theoretical direct band gap of 4.05 eV for the Ba0.5Sr0.5Al2O4 host. In addition, the prepared fluorescent powder can be used to prepare fluorescent flexible films. This film does not change the characteristic emission of Eu2+ ions and has more stable physicochemical properties, which may be more suitable for use in harsh environments. Also, the fluorescent powder can be blended with polyacrylic acid to form colorless anti-counterfeiting ink that can be applied to banknotes as an anti-counterfeiting mark. A clover pattern was successfully printed using screen-printing technology, proving its potential application in the field of anti-counterfeiting.
Production and Characterization of Active Pectin Films with Olive or Guava Leaf Extract Used as Soluble Sachets for Chicken Stock Powder
Authors: Sabbah Mohammed , Al-Asmar Asmaa , Younis Duaa , Al-Rimawi Fuad , Famiglietti Michela , Mariniello Loredana
Published: July 2023

The goal of this study was to improve the functionality of two pectin (PEC) edible films by incorporating olive leaf extract (OLE) or guava leaf extract (GLE). Different concentrations of OLE or GLE (0.1 and 0.2% w/v) were used, and 30% glycerol was added as a plasticizer. The obtained films were evaluated for their mechanical properties, antioxidant activity, thickness, color, opacity, permeability to gases and water vapor, moisture content, and moisture uptake. Soluble sachets were then prepared and filled with chicken stock powder. The results indicated that incorporating OLE or GLE into the PEC films significantly increased their opacity, greenness, and antioxidant activity, which increased from 8.5% in the control to 83.9% when 0.2% GLE was added. Additionally, the films had lower water vapor permeability than the control film. The moisture uptake of the films was also significantly increased when GLE was added. Furthermore, the developed sachets were tested in real-life scenarios, mirroring their intended usage in households. After being introduced to boiling water, the sachets rapidly dissolved within seconds. These results suggest that OLE or GLE, as natural additives, can be used to improve the functionality and activity of edible films.
Mechanisms of Premature Fracture in Modular Neck Stems Made of CoCrMo/Ti6Al4V and Ti6Al4V/Ti6Al4V Alloy
Authors: Dolinar Drago , Gorenšek Miro , Avsec Klemen , Šetina Batič Barbara , Hočevar Matej , Godec Matjaž , Žužek Borut , Debeljak Mojca , Jenko Monika , Grant John T. , Kocjančič Boštjan
Published: July 2023

In this paper, we present the mechanisms of premature fracture of modular neck stems in two case studies: (I) when the neck and stem are both made of the same Ti6Al4V alloy, and (II) when the neck and stem are made from two different alloys, CoCrMo and Ti6Al4V alloy. Our study integrates two orthopedic patients who have undergone primary uncemented THA for usual indications in two orthopedic centers (Community Health Centre and University Medical Centre). Both centers are part of the national public health care system. Both surgeries were performed by two skilled orthopedic surgeons with more than 10 years of experience in THA. The survivorship of the modular neck of cast CoCrMo alloy was 24 months. The survivorship of the modular neck from Ti6Al4V alloy was 84 months. Multivariate analyses were performed to assess the differences in the fretting, corrosion, and fatigue of the two prematurely failed modular neck stems: stereo light microscopy (SLM), scanning electron microscopy (SEM), X-ray energy-dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). Patient demographic information, including sex, age, body mass index, survivorship of implants, and reason for the revision, was collected from medical records. We found that fretting and fatigue occurred on both neck-stem retrievals due to additional galvanic corrosion, but the CoCrMo/Ti6Al4V alloy system suffered more corrosion due to additional galvanic corrosion and fractured earlier than the Ti6Al4V/Ti6Al4V metal alloy system. Both metallic alloy systems used in this application are known to be highly corrosion-resistant, but the bio-tribo-corrosion processes need to be understood in detail and characterized so that appropriate improvements in design and materials can be made.
Structure and Properties of Spark Plasma Sintered SiC Ceramics with Oxide Additives
Authors: Zhambakin Dauren , Zhilkashinova Almira , Abilev Madi , Łatka Leszek , Pavlov Alexandr , Tuyakbaev Bauyrzhan , Zhilkashinova Assel
Published: July 2023

This article describes spark plasma sintering of ceramics based on silicon carbide with nanoadditives, as follows: MnOnano 5.5 wt. % + Al2O3nano 2.0 wt. % + SiCnm (37–57 wt. %) + SiCµm (31–51 wt. %) + SiO2µm 4.5 wt. %. Sintering was carried out at 2000 °C. The diffraction pattern of the analyzed sample showed the presence of silicon carbide with a hexagonal crystal lattice. Residual amounts of rhombohedral SiC, α-Fe, and a solid solution of silicon in iron were also found. The method of thermogravimetric analysis established the change in mass, heat flow, temperature of the samples, and the change in the partial pressures of gases during the experiment. Samples obtained by SPS show a higher density of the material at the level of 3.3 g/cm3, average mechanical strength of 454 MPa, and microhardness of 35 GPa, compared with samples obtained by liquid-phase sintering. The SPS method also made it possible to obtain materials with a higher density (by 8%) and practically no significant crystal growth compared to samples obtained by liquid phase sintering. The results of the study facilitate the achievement of a combination of new approaches to the design of compositions and the technology of manufacturing SiC ceramics, which significantly expands their areas of application.
Surface-Enhanced Raman Spectroscopy of Benzylpenicillin Using Silver Nanocrystals Modified with Moroccan Plant Extracts
Authors: Fernine Yasmine , Martins Natércia C. T. , Taleb Mustapha , Trindade Tito
Published: July 2023

Green chemical routes for the synthesis of colloidal metal nanocrystals have been of great interest, namely in the context of nanosciences associated with biological applications. Among these methods, the synthesis of metal colloids using medicinal plant extracts originates nanocrystals having surfaces modified with chemical compounds of biological origin, which can be further explored in association with conventional pharmaceutics. In this context, the development of spectroscopic methods that seeks for understanding the potential benefits of using formulations that contain natural compounds and metal nanoparticles with therapeutic properties is of relevance. This research describes the chemical synthesis of silver colloids via the reduction of Ag(I) in the presence of distinct aqueous plant extracts. The selected extracts were obtained from Moroccan plants that have been used in traditional therapeutic practices over the centuries. The method led to stable colloids comprising polydispersed Ag nanocrystals that show surface-enhanced Raman scattering (SERS) activity. As an illustrative scenario, these colloids have been applied to the SERS detection of the natural β-lactam antibiotic benzylpenicillin, also known as penicillin G (PG). Our results indicate that all the Ag colloids tested with the different plant extracts are SERS-active for PG without showing detrimental interference from chemical adsorbates originated from the extracts. Therefore, this spectroscopic method can be further explored for monitoring nanoformulations of pharmaceuticals and metal colloids obtained using biological synthesis.
Heavy Alkyl-Benzene Sulfonate-Controlled Growth of Aragonite-Based Polymorphic CaCO3 Crystals in Emulsion
Authors: He Weiwei , Hu Junqing , Sun Weihao , Liu Jiqiong , Guo Hongguang , Zhao Changming , Wang Qingguo , Liu Xiangbin , Cai Meng , Shi Weiguang
Published: July 2023

The non-natural mineralization of CaCO3 with special structures or morphologies is generated during the migration of crude oil and is the main form of scale in alkaline/surfactant/polymer (ASP) flooding in oilfields, adversely affecting oil recovery and causing environmental pollution. To date, the mineralization of aragonite superstructures and the role of heavy alkyl-benzene sulfonate (HABS) in mineralization are still unclear. In this work, aragonite-based superstructures of CaCO3 crystals were obtained in an O/W emulsion with HABS to help deepen the understanding of the diversified growth of CaCO3 scaling in oilfields. As a result, rosette-like, bouquet-like, and dumbbell-shaped CaCO3 crystals with vaterite–aragonite, aragonite, and calcite–aragonite phases were formed with 200 mg/L HABS concentration at 45 °C for 60 min and spherical vaterite phase stabilized at a high HABS concentration (800 mg/L and 1000 mg/L). Rhombohedral calcite content experienced a fluctuation of about 40% as the HABS concentration varied. Needle-like and bundle-like aragonite precipitates were generated with increasing temperatures from 65 °C to 85 °C. Thus, HABS affects the nucleation and growth of the precipitated CaCO3 solid, leading to modifications in the structure and morphology of the crystals. The synergistic effect between HABS and temperature can regulate ion pairs with the calcium ions and block sites that are essential to the incorporation of new solutes into the crystal lattice, which leads to the heterogeneous nucleation of vaterite and aragonite on calcite, forming aragonite-based superstructures in kerosene emulsion. This work may enrich the understanding of CaCO3 mineralization in oilfields, and also provide a novel strategy for manufacturing organic–inorganic composites.
Comparative Analysis of Gut Microbial Community Structure of Three Tropical Sea Cucumber Species
Authors: Wang Yanan , Zhang Yue , Jia Chenghao , Xu Qiang , Rong Yun , Xu Zening , Wang Yuanhang , Gao Fei
Published: July 2023

Based on 16S rRNA gene high-throughput sequencing technology, the microbial community structure in the gut of three tropical sea cucumber species, Holothuria atra, Stichopus chloronotus, and S. monotuberculatus, and their habitat sediments were analyzed. The OTUs in the gut contents of S. monotuberculatus, S. chloronotus, H. atra, and their sediments were 2489 ± 447, 1912 ± 235, 1628 ± 150, and 4162 ± 94, respectively. According to alpha diversity analysis (Ace, Chao1, Shannon, Simpson), the richness and diversity of microflora in the gut of all three sea cucumber species were significantly lower than that in sediments (p < 0.01). Anosim analysis showed that the intra-group differences were less than the inter-group differences (R > 0), and the microbial community composition of the sediment was distinctly different from those of three sea cucumber species (p < 0.05). UPGMA tree and Anosim analysis also revealed that the gut microbial communities of H. atra and S. chloronotus were more similar than that of S. monotuberculatus. Proteobacteria was the predominant phylum in all samples, and there was no significant difference in relative abundance among all groups. Actinobacteria was also a dominant phylum, and the relative abundance in S. chloronotus was significantly higher than that in other samples (p < 0.05). Potential probiotics and sequences related to Lactobacillus and Pseudomonas that may be developed for sea cucumber culture were also found in the study. It is speculated that the main reason for the difference in microbial communities between gut microbiota and environmental sediments may be the unique and quite different environment in the digestive tract of sea cucumbers. Whereas, the differences in gut microbiota among the three sea cucumber species were caused by selective feeding. These findings may provide basic data for tropical sea cucumber gut microflora studies and assist in the sea ranching and aquaculture development of the tropical sea cucumber species.
Multiple Chemical Signals in Male Rock Lizards: Femoral Gland Secretions and Feces May Provide Information on Body Size but Using Different Compounds
Authors: Martín José , Rodríguez-Ruiz Gonzalo , López Pilar
Published: July 2023

Chemosensory communication in lizards may be based on multiple compounds coming from multiple sources. Both secretions from external epidermal glands, and internal cloacal glands and feces are known to convey information (sex, familiarity, body size, etc.) for conspecifics. However, although some compounds in femoral gland secretions have been characterized and their function examined, there is very little information on potential semiochemicals in cloacal products and feces. More importantly, it is not well-known whether the compounds and information from multiple sources are redundant, complementary, or different. We analyzed the lipids in femoral gland secretions and feces of male Carpetan rock lizards (Iberolacerta cyreni) and examined which compounds might predict body size. We found many compounds in feces, mainly steroids, alkanes, and branched alkanes, while the main compounds in femoral secretions were steroids and fatty acids. The body size of males was related to the proportions of some alkanes, alkenes, and terpenoids in feces, while it is related to the proportions of some steroids and fatty acids in femoral secretions. There were also differences in the chemical profiles of feces of males and females, which may allow sex recognition. Therefore, femoral secretions and feces may both inform on males’ sex and body size, but the chemical bases of this information are different depending on the source.
Morphometric Analysis of a Trapdoor Spider (Araneae, Idiopidae) across Different Brazilian Biomes Reveals the Geographic Variation of Spiders from the Caatinga Biome
Authors: Fonseca-Ferreira Rafael , Morales Millke Jasmine A. , Carvalho Leonardo S. , Guadanucci José Paulo L.
Published: July 2023

Widespread species are exposed to different environmental drivers and can consequently present variations in body shape and/or size. Trapdoor spiders of the genus Idiops are generally associated with a sedentary lifestyle and limited dispersion. However, the species Idiops pirassununguensis has a wide distribution, occurring in a diverse range of distinct environmental conditions, with their presence recorded in the Amazon, Caatinga, and Cerrado Brazilian biomes. We investigated how their morphological variation is structured regarding the biomes in which they occur through a morphometric analysis of the linear measurements and morphogeometric shapes of 64 specimens. Combining different methods proved to be a valuable approach to understanding how the spider’s morphology varies in different environments. The results were congruent and complementary, indicating intraspecific geographic variation, with the Caatinga specimens being distinct from their biome conspecifics. In Caatinga, a biome with periods of severe drought and warm climate, I. pirassununguensis specimens were found to be smaller, in addition to having narrower and elongated sternums and shorter legs. The morphological structuring herein is consistent with the results found comparing animals from Caatinga and other Brazilian biomes. Despite differences in their non-sexual structures, the specimens share a set of diagnostic sexual characteristics for the species, allowing all individuals to be classified as belonging to the same species.
BASCULE Syndrome Associated with Autoantibodies
Authors: Gambichler Thilo , Barras Milan , Stranzenbach Rene , Scheel Christina H. , Abu Rached Nessr
Published: July 2023

Dear Editors: In 2016, Bessis and coworkers first reported Bier anemic spots, cyanosis, and urticaria-like eruption (BASCULE) syndrome [...]
Enhancement of Diabetic Retinopathy Prognostication Using Deep Learning, CLAHE, and ESRGAN
Authors: Alwakid Ghadah , Gouda Walaa , Humayun Mamoona
Published: July 2023

One of the primary causes of blindness in the diabetic population is diabetic retinopathy (DR). Many people could have their sight saved if only DR were detected and treated in time. Numerous Deep Learning (DL)-based methods have been presented to improve human analysis. Using a DL model with three scenarios, this research classified DR and its severity stages from fundus images using the “APTOS 2019 Blindness Detection” dataset. Following the adoption of the DL model, augmentation methods were implemented to generate a balanced dataset with consistent input parameters across all test scenarios. As a last step in the categorization process, the DenseNet-121 model was employed. Several methods, including Enhanced Super-resolution Generative Adversarial Networks (ESRGAN), Histogram Equalization (HIST), and Contrast Limited Adaptive HIST (CLAHE), have been used to enhance image quality in a variety of contexts. The suggested model detected the DR across all five APTOS 2019 grading process phases with the highest test accuracy of 98.36%, top-2 accuracy of 100%, and top-3 accuracy of 100%. Further evaluation criteria (precision, recall, and F1-score) for gauging the efficacy of the proposed model were established with the help of APTOS 2019. Furthermore, comparing CLAHE + ESRGAN against both state-of-the-art technology and other recommended methods, it was found that its use was more effective in DR classification.
The Value of Four-Quadrant Cervical Biopsy in Women with Different Colposcopic Impressions
Authors: Chu Mandy Man-Yee , Cheung Charleen Sze-Yan , Ngu Siew-Fei , Tse Ka-Yu , Ip Philip Pun-Ching , Cheung Annie Nga-Yin , Ngan Hextan Yuen-Sheung , Chan Karen Kar-Loen
Published: July 2023

The aim of this study was to compare the diagnostic efficacy of colposcopic-directed biopsy and four-quadrant biopsy in detecting high-grade cervical intra-epithelial neoplasia (CIN). Women attending three women’s clinics for routine cervical screening were recruited. Colposcopy was arranged for women with any cytologic abnormalities greater than atypical squamous cells of undetermined significance (ASCUS), two consecutive ASCUS results or positive HPV testing. During colposcopy, a cervical biopsy was taken from the most suspicious area, but more than one biopsy was allowed. Four-quadrant biopsies at 3, 6, 9 and 12 o’clock and an endocervical curettage were also taken in all cases. A total of 1522 colposcopies were performed in 1311 subjects from June 2010 to August 2017, with 118 cases of high-grade CIN diagnosed. Colposcopic-directed biopsy detected 50.8% of the 118 high-grade CIN, while four-quadrant biopsy detected 86.4% (p < 0.0001). Twenty-seven cases (22.9%) of high-grade CIN were diagnosed in women with normal or unsatisfactory colposcopy. Among the 64 cases with low-grade colposcopic impression, four-quadrant biopsy detected significantly more high-grade CIN (53 cases, 82.8%) than colposcopic-directed biopsy (35 cases, 56.3%) (p = 0.0011). Four-quadrant cervical biopsies should be considered for all women with an abnormal smear or positive HPV testing, especially in patients with low-grade/normal/unsatisfactory colposcopy.