bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Applications of Plant Virus Nanoparticles in Cancer Treatment and Nanomedicine
Authors: Muhammad Majid  , Mansor Hussain  , Hamza Khaliq  , Usman Abbas  , Roha Tariq  , Abdul Qayoom
Published: January 2025

Plant virus nanoparticles (VNPs) are inexpensive to produce, dependable, and reusable and have emerged as a versatile and promising platform in nanomedicine, particularly cancer therapy. These biogenic nanostructures possess unique physicochemical properties, including biocompatibility, biodegradability, and structural uniformity, making them ideal candidates for targeted drug delivery. The ability of such nanoparticles to encapsulate chemotherapeutic agents and functionalize with tumor-specific ligands facilitates precise delivery to cancerous tissues, minimizing off-target effects and enhancing therapeutic efficacy. In addition, plant viral vectors (VLPs) are an attractive option for causing anti-tumor immunity because they are undoubtedly secure, harmless, and suitable for mass manufacture and pharmacological adaptation. This review delves into the molecular architecture of plant virus nanoparticles, their functional modifications, and the mechanisms by which they interact with cancer cells. Additionally, it highlights preclinical studies and emerging clinical applications, addressing both the opportunities and challenges in translating VNPs from bench to bedside. By exploring the anticancer potentials of VNPs, this paper aims to underscore their role in shaping the future of sustainable, plant-derived nanotechnology for oncology.
Estrategias agroforestales para enfrentar el cambio climático mediante un análisis de la literario
Authors: Caicedo-Aldaz Julio Cesar , Flores-Mancheno César Iván
Published: January 2025

The article examines the role of agroforestry practices as key strategies to mitigate and adapt to climate change. Through a literature review, environmental benefits such as carbon sequestration and biodiversity conservation are analyzed, highlighting that agroforestry systems can sequester between 0.2 and 3.1 tons of carbon per hectare annually, depending on species and local conditions. In addition, these practices reduce greenhouse gas emissions by reducing the use of chemical inputs and optimizing resource management. At the socioeconomic level, agroforestry systems diversify sources of income through the production of timber, fruits and environmental services, improving the economic resilience of rural communities. However, their implementation faces challenges related to resource availability, technical training and political support. The article concludes that an integrated approach combining economic incentives, appropriate policy frameworks and the active participation of local communities is essential to maximize their impact. This study provides a comprehensive view on how to integrate agroforestry practices into sustainable strategies to address climate change and promote rural development.
Suri-Politikal: Mga Ideolohiyang Politikalng Kaliwang Panel ng Obrang FilipinoStruggles Through History ni Botong
Authors:   De La Salle University, Maryhill College, Inc., Serote Cristy Allen
Published: January 2025

Even without an exact photograph taken from every scene of history, it was still successfully displayed by art like the famous mural, “Filipino Struggles Through History.” The Filipino Struggles Through History by renowned artist Carlos “Botong” Francisco, is composed of four panels and each panel contains historical scenes from different periods. From the four panels, the researchers analyzed the left panel focusing on the experience and situation of the country from the pre-colonial period to the central part of the 19th-century Spanish conquest. The researchers used Barthes’ semiology and Hans Slomp’s political ideology which was modified by F.P.A Demetrio in analyzing the political ideology of the left panel. Through the study, it was identified that a variety of signs and symbols reflect the reality of society at a time. The study also found that the dominant ideology of sections on the left panel was moderate. If Botong wants to bring his art specifically to ordinary Filipinos, it is important to see political ideology because it allows a deep understanding of history and a guide to a high regard for identity as Filipinos.
Durkheim Revisited: Possible Contribution to the Understanding of Gramsci’s Notion of Hegemony
Authors:   University of the Philippines-Diliman College of Social Sciences and Philosophy-Graduate Student, Fernandez Artchil
Published: January 2025

The paper attempts to explore the possibility of using Durkheim to understand the Gramscian notion of hegemony building on the claim that Gramsci’s idea is fragmentary and contentious. Durkheim’s concepts such as social solidarity, integration, rites and collective conscience the paper argues maybe deployed to comprehend Gramsci’s notion of hegemony particularly consent generation. The paper also contends that Durkheim’s ideas on the state and secondary groups voluntary organizations (civil society) may be helpful in explaining the Gramscian concept of consent building. In effect, the paper also tries to demonstrate that sociological positions that are viewed as rivals can complement each other. Sociologists should do more explorations in areas of convergence rather than divergence of sociological positions.
Commodity Fetishism and the Crisis of Contemporary Art
Authors:   San Beda University, Manila, Cruz Maria Eliza
Published: January 2025

This paper centers on the implicit metaphysics beyond the Theory of Relativity and the Principle of Indeterminacy – two revolutionary theories that have changed 20th Century Physics – using the perspective of Husserlian Transcedental Phenomenology. Albert Einstein (1879-1955) and Werner Heisenberg (1901-1976) abolished the theoretical framework of Classical (Galilean-Newtonian) physics that has been complemented, strengthened by Cartesian metaphysics. Rene Descartes (1596-1850) introduced a separation between subject and object (as two different and self- enclosed substances) while Galileo and Newton did the “mathematization” of the world. Newtonian physics, however, had an inexplicable postulate of absolute space and absolute time – a kind of geometrical framework, independent of all matter, for the explication of locality and acceleration. Thus, Cartesian modern metaphysics and Galilean- Newtonian physics go hand in hand, resulting to socio- ethical problems, materialism and environmental destruction. Einstein got rid of the Newtonian absolutes and was able to provide a new foundation for our notions of space and time: the four (4) dimensional space- time; simultaneity and the constancy of velocity of light, and the relativity of all systems of reference. Heisenberg, following the theory of quanta of Max Planck, told us of our inability to know sub- atomic phenomena and thus, blurring the line between the Cartesian separation of object and subject, hence, initiating the crisis of the foundations of Classical Physics.

But the real crisis, according to Edmund Husserl (1859-1930) is that Modern (Classical) Science had “idealized” the world, severing nature from what he calls the Lebenswelt (life- world), the world that is simply there even before it has been reduced to mere mathematical- logical equations. Husserl thus, aims to establish a new science that returns to the “pre- scientific” and “non- mathematized” world of rich and complex phenomena: phenomena as they “appear to human consciousness”.
Muslim-Christian Goodness of Life as a Philosophical Perspective
Authors:   Notre Dame University in Cotabato City, Del Rosario Jaime
Published: January 2025

Being Filipinos delving into philosophical discussions necessitates expanding the majority Christian viewpoint that crosses religious affiliation into the Muslim viewpoint as well. In Mindanao, particularly where Filipinos are a blending of Muslims, Christians, various Indigenous People’s communities, and mestizos of genetic and/or cultural hybridity of human identification even extend to various others for further consideration while in the paper the focus is on Muslim-Christian understanding of the notion of goodness of life. Philosophizing in this locality can expand the horizon of Filipinos who philosophize outside of Mindanao. A philosophical perspective needs to understand the ongoing blending of the Muslim and the Christian. Their practices manifest meaning of goodness of life as in their articles of faith, iman in Islam for existence of Allah and life after death, while the Decalogue and sacrament-generated reaching out to neighbors in Christianity may find differences, and yet philosophically bridging similar good aspirations, as supported by the philosophical stance of Emmanuel Levinas exploring the summons on the being of the ‘I’ towards the other for pursuing originary goodness. Similar notions of a creator god emulated in living out love and mercy build up valuing primordial goodness of life itself so that the differently religious other’s life is inviolable. Philosophizing in both religions as expressed in their major tenets deduces the rational human recognized in the other that brings about a philosophical perspective for the Filipinos that leads to averting violence by bringing about peace.
Ang Prusisyon Tuwing Semana Santasa Lungsod ng San Pablo City, bilang Assemblage
Authors:   De La Salle University Integrated School, Servo Princess Gissel D
Published: January 2025

The purpose of this study is to narrate San Pablo City’s historical practice of celebrating the procession during the Holy Week season. Specifically, the researcher wishes to answer the following questions concerning the town’s annual procession. Why was the assemblage formed?; What is the narrative of the assemblage in the town of San Pablo according to the following: combustion, division, and reconstruction?; How does the assemblage represent the culture and faith of the people of San Pablo? The researcher employed Deleuze’s and Guattari’s concept of assemblage to present the sequence of important events behind the town’s celebration of the procession during the festivity. To gather data, the researcher conducted a face-to-face and a telephone interview with the members of the church, a private religious organization known as Samahan ng Mahal na Pasyon, and the devotees and owners of life-size images who actively participate in the annual celebration.
Ang Artista Sa Panahon Ng Tiktok, Vlog,at Madlang Kabulaanan
Authors:   University of the Philippines Diliman, Tiongson Nicanor
Published: January 2025

featured article
A Systematic Literature Review on AI Approaches To Address Data Imbalance In Machine Learning
Authors: Apu Kutub Uddin , Ali Mohammad
Published: January 2025

Data imbalance is a pervasive issue in machine learning, where unequal class distributions often lead to biased models and poor predictive performance, particularly for underrepresented minority classes. This systematic review examines a range of strategies employed to address data imbalance, encompassing data-level methods, algorithm-level techniques, hybrid approaches, and advanced AI-driven solutions. A total of 92 peer-reviewed studies were analyzed, providing comprehensive insights into the methodologies, applications, and effectiveness of various techniques. Data-level approaches, such as SMOTE and its extensions, were identified as widely applied but faced challenges in introducing noise and redundancy. Algorithm-level methods, including cost-sensitive learning and ensemble techniques, demonstrated robust performance but required careful parameter tuning and computational resources. Hybrid approaches combined the strengths of these strategies, offering enhanced accuracy and adaptability for complex imbalance scenarios. Advanced AI techniques, such as GANs, VAEs, and deep learning architectures, emerged as powerful tools for handling high-dimensional and imbalanced datasets but were often constrained by computational demands and overfitting risks. The review also identified significant gaps, including the lack of standardized evaluation metrics, which hinder the comparability of findings across studies. By synthesizing these insights, this study provides a foundation for addressing recurring challenges and advancing research in mitigating data imbalance across diverse applications.
The Promotion of Teaching Excellence in Higher Education: A Comparison of the Australian and New Zealand Approaches
Authors:   Swinburne University of Technology, Abbott Malcolm
Published: January 2025

This paper compares the structures and operations of the Australian Learning and Teaching Council (ALTC) and New Zealand's Ako Aotearoa National Centre for Tertiary Teaching Excellence. Both organizations were established in the mid-2000s to promote teaching excellence in higher education, coinciding with institutions in both countries striving to enhance their research profiles due to evolving funding criteria. Despite similar objectives, the two bodies differ significantly in scale and focus. The ALTC, with substantially larger funding, undertakes a broader range of activities compared to its New Zealand counterpart. Nonetheless, both organizations exert comparable influence within their respective higher education sectors.
Integrating Technology in Education: Moving the TPCK Framework towards Practical Applications
Authors:   University of Manitoba, Hechter Richard P. , Phyfe Lynette D. , Vermette Laurie A.
Published: January 2025

This theoretical paper offers a conceptual interpretation of the Technological, Pedagogical, and Content Knowledge (TPCK) framework to include the role of context within practical classroom applications. Our interpretation suggests that the importance of these three knowledge bases fluctuates within each stage of teachers’ planning and instruction, depending on classroom contexts and desired learning outcomes. Applications for the science classroom are provided. The implications of this conceptual interpretation offer pragmatic ways of understanding the TPCK model within preservice and inservice teacher education programs, professional development, and classroom practice.
Using a Template to Facilitate External Peer Preview of Curriculum: A Variation on the PRoT Theme
Authors:   James Cook University, Sealey Rebecca
Published: January 2025

Peer reviewing of teaching and curriculum in Higher Education is a common practice aimed at both quality assurance and professional development. External review of curriculum prior to implementation appears less common. The aim of this project was to develop, implement and evaluate a user-friendly process for external peer preview of teaching (PPoT). A peer preview template was designed by a subject coordinator and, following initial internal review, was used by two external academics and an external clinician to peer preview new curriculum. The template and curriculum were designed specifically to capture University, industry and professional accreditation requirements as well as University graduate attributes, course-specific learning outcomes and diversity of student learning styles. The peer previewers reported that the template was easy to use and not overly time consuming. Identified strengths of the process were the inclusion of a variety of previewers and use of check boxes/circle responses (time efficient responses). The review was performed by a small sample; however, suggestions for further improvement included the reduction of repetition with open-ended questions and inclusion of a neutral response option. The user-friendly peer preview template has been included for multi-disciplinary involvement in future external peer previews of Higher Education curriculum.
Peer Assessing in Higher Education: Perspectives of Students and Staff
Authors:   James Cook University, Sealey Rebecca Maree
Published: January 2025

This paper provides an overview of contemporary peer assessment literature and reports findings from a project investigating the subjective experiences and attitudes of students and staff participating in a peer assessment task. Twenty-four students, a lecturer, and a subject coordinator participated in the study. Students completed pre- and post-peer assessment task surveys, and the lecturer participated in a one-on-one interview. While students predominantly agreed that peer assessment was a positive and worthwhile experience, three themes emerged for future consideration: validity and objectivity, confidence, and workload.
פתח דבר: מין. כסף. רעש.
Authors: סתר שאול
Published: January 2025

בראשית שנות השבעים של המאה הקודמת יצר פייר פאולו פזוליני, המשורר, במאי הקולנוע והאינטלקטואל האיטלקי, שתהודתו האמנותית והציבורית הייתה בשיאה באותה עת, את הטרילוגיה של החיים — שלושה סרטים המבוססים על אסופות סיפורים קדם–מודרניות: דקמרון, על ספרו של בוקאצ׳יו שנכתב במהלך מגפת המוות השחור באמצע המאה הארבע– עשרה; סיפורי קנטרברי, בעקבות החיבור המחורז של צ׳וסר מסוף אותה מאה; ואלף לילה ולילה, מתוך סיפורים מתור הזהב המוסלמי. בתקופה הסוערת שלאחר מחאות ,1968 תחילת הגל המיליטנטי באירופה, המלחמה האימפריאלית בווייטנאם, וההפיכות והפיכות– הנגד באמריקה הלטינית, פזוליני הפנה עורף להווה ולמאבקים הניטשים בו ופנה אל העבר הרחוק — אך לא אל העבר הקדום ורב ההוד של הטרגדיה (כמו בסרטיו אדיפוס המלך או מדיאה), כי אם אל הסיפורים העממיים, סיפורי אהבה, סיפורי ביזה וסיפורי כפירה, שנכתבו בשפות הוורנקולריות של אירופה או בערבית ומתרחשים בכפר, בעיירה, במנזר ובשוק; בחברה שלפני ההסדרה הגדולה של המדינה וההאחדה הכוללת של ההון. אלה סרטים ילדיים, מלאי תום, קסומים, סרטים שמנסים לשוב אל הקסם הראשוני של המדיום הקולנועי בטרם נטמע כולו בתרבות הצריכה, סרטים לא אקטואליים ולא אידיאולוגיים, הגופים — שפזוליני יצר על מנת ״להציג את הגופים ואת הסמל הבולט שלהם, הסקס״. מדברים, צוחקים, נוהמים, נופחים; לא פרטים מובחנים, אינדיווידואלים פסיכולוגיים, אלא דמויות גנריות או אלגוריות, או רק צבר של איברים; וסקס, או מין — כמרחב של עונג וחשק, שכרוך בהיפעלות האיברים אך גם בתעייה ובפליאה.
Kepastian Hukum Notaris Menerapkan Cyber Notary Dalam Verlidjen Akta Notaris Secara Digital
Authors: Kinasih Nadia Pitra
Published: January 2025

The vagueness of legal norms or vague norms in the UUJN, especially Article 15 paragraph (3), affects the implementation of notary authority in the digital era. This ambiguity has the potential to cause problems, especially in the inconsistency between Article 16 paragraph (1) letter m of the UUJN and Article 15 paragraph (3) of the UUJN, which creates a conflict between the obligations and authorities of notaries in making deeds face to face or in person. The purpose of this study is to ensure legal certainty in making notarial party deeds digitally and how the impact of the implementation of cyber notary in Indonesia in making party deeds regarding signing and reading face to face online. This study uses a normative legal research method with a statute-approach and comparative-approach, as well as qualitative analysis. Data were collected through literature studies from primary, secondary, and tertiary legal sources. The conclusion of the study emphasizes the need for clear and comprehensive legal regulations to regulate the use of digital technology in making notarial deeds, including a strong security system and appropriate notary authorization. An important requirement in making an authentic notarial deed is the reading and signing of the deed, which can be done electronically through media such as video conference. Electronic signature or digital signature, it is expected that the making of a notarial deed digitally can be realized with legal certainty guaranteed through harmonization of laws and regulations. The impact of using cyber notary includes ease of access, process efficiency, time flexibility, cost reduction, document security, and regulatory adjustments. Overall, notaries have an important role in non-governmental public services, and the use of technology in making deeds digitally can be an efficient and practical alternative in supporting legal certainty. However, attention is needed to aspects of data security and regulations that are in accordance with technological developments in the digital era.
Keywords: Notary; Cyber Notary; Verlidjen
Examining Different Mind Frames of Primary School Students in the Light of Gardner’s Multiple Intelligence Theory
Authors: Bibi Saima , Noor Yusra
Published: January 2025

The present study aimed to investigate the various mindsets of fifth-grade primary school students in the context of Gardner’s Multiple Intelligence Theory. The purpose of this study was to investigate the various mental states of primary school students and analyze the students who exhibit multiple intelligences the most and least. The population of the study comprised of seven hundred nine (709) public primary schools in six tehsils of district Attock, with 362 girls and 347 boys schools. Two tehsils, Attock and Hazara, were selected using cluster sampling. Two thousand eight hundred and twenty-seven (2827) students were enrolled in public primary schools in Attock and Hazara tehsil (1336/F and 1491/M). The sample was randomly selected: 1001 (477/F and 524/M) students for the study. A questionnaire was developed to gather data from Grade 5th students of Tehsil Hazara and Tehsil Attock. Percentage, mean, SD, and chi-square were used to analyze the data. The study revealed that male students had higher naturalistic and logical-mathematical intelligence levels than their female counterparts. While verbal intelligence, spatial-visual, bodily-kinesthetic, intrapersonal, and existentialist intelligence were comparatively higher in female students, musical intelligence and interpersonal intelligence did not significantly differ from one another. It is recommended that eaching and learning activities be incorporated according to the student’s frame of mind for better results. Personal and existentialist intelligence were comparatively higher in female students; musical intelligence and interpersonal intelligence did not significantly differ from one another. It is recommended that teaching and learning activities be incorporated according to the student’s frame of mind for better results.
Environment and the Unconscious in Eugene O’Neill’s Desire under the Elms
Authors: Nesa Meherun
Published: January 2025

This study explores the interplay between the environmentand the unconscious in Eugene O’Neill’s Desire under the Elms,examining how the characters’ repressed desires and unresolvedConflicts shape their lives and relationships. Drawing primarilyon Freudian and Jungian psychoanalytic theories, the paperinvestigates the influence of the unconscious on the physicaland emotional environment of the Cabot family. It argues thatunchecked desires and deprivation foster a cycle of violence,impulsiveness, and dysfunction within the family, culminating intragedy. The characters’ inability to confront their unconsciousor engage in meaningful reflection exacerbate their isolation andsuffering. Set in a bleak New England farmhouse, the oppressiveenvironment mirrors the inner turmoil of the characters, creatinga physical and symbolic stage for their struggles. Passion andgreed drive exploitative behaviors, rendering the Cabot familyincapable of forming genuine connections. The analysis showsthat without conscious effort to mediate the unconscious, thecharacters remain trapped in destructive patterns. Employingpsychoanalytic concepts such as Freud’s tripartite psyche andJung’s archetypes, this study demonstrates how the unconsciousand environment interconnect to dictate human behavior. Theresearch underscores the importance of self-awareness andreflection in transcending primitive impulses and fosteringharmonious relationships.
Effect of Directly Recruited and Promoted Elementary Teachers’ Reflective Skills on Academic Achievements of Students in AJK
Authors: Nazir Nadia , Rahat Rubina , Bibi Maria
Published: January 2025

The current study was conducted to find out the effects of directly recruited and promoted elementary teachers’ reflective skills on academic achievements of students in AJ&K. Reflective teaching practices assist the teachers to plan, implement and ameliorate their performance after diligent and meditative reconsideration of their strengths and weaknesses. Researcher conducted quantitative and descriptive research to find out the reflective skills practiced by directly recruited and promoted teachers. Furthermore, researcher also tried to find out the effect of directly recruited and promoted teachers’ reflective skills on academic achievement of students. Directly recruited and promoted elementary teachers and male students of public sector institutes (Grade 8th) were chosen as population. Researcher exercised random sampling technique to accumulate the data. The results collected from Elementary Board Bagh facilitated the researcher in computing the academic achievement of pupils. Researcher used SPSS to analyze the data and applied Mean and Regression to get the required results. The findings revealed that usage of reflective practices have a significant impact on academic achievements of students. Furthermore, directly recruited teachers were found comparatively better than promoted teachers and their students also enjoyed better academic achievements. It is recommended that teachers May run their eyes over latest pedagogical materials to update their knowledge, education department may ensure refresher courses and trainings to equip teachers with modern tools and teachers may ensure the usage of modern tools and strategies including case studies, motivation, record retention, analysis of students’ achievements and knowledge about their learning styles etc. Last but not the least, government may ensure free and fair direct recruitments through National Testing Service (NTS) and Public Service Commission (PSC) to ensure quality education and to ameliorate the academic achievements of students.
The impact of COVID-19 on patients affected by rare diseases and congenital disorders in South Africa: A scoping review
Authors: Gomes M C M , Malherbe H L
Published: January 2025

Rare diseases (RDs) are individually rare but collectively common, affecting an estimated 1 in 15 individuals in South Africa (SA). Patients with an RD often face a long diagnostic odyssey (>5 years on average) and many obstacles in accessing healthcare. A scoping review was conducted to assess the impact of the COVID-19 pandemic on the SA RD community. Fourteen studies met the inclusion criteria and were explored using thematic analysis, which showed that RD patients were further marginalised during the pandemic, particularly in access to healthcare. Increased inclusivity in policy creation and integrated community-based healthcare are recommended to ensure that RD patients are not an afterthought in future crises.
Défis dans les écoles franco-ontariennes : analyse de la pensée systémique chez des gestionnaires de l’éducation
Authors: IsaBelle Claire , Dulude Éliane
Published: January 2025

À la lumière des défis de l’école recensés dans un article publié par Lessard en 1994, nous tentons d’actualiser les écrits sur ces enjeux. Notre étude vise à comprendre les défis que doivent relever les organisations éducatives ainsi que les transformations proposées pour favoriser la réussite éducative des jeunes, selon le point de vue de gestionnaires de l’éducation en milieu francophone en Ontario. Pour analyser leur compréhension quant aux défis organisationnels, nous utilisons les caractéristiques de la pensée systémique adaptées à un leader scolaire de Shaked et Schechter. Dix gestionnaires ont participé à un entretien semi-dirigé. De notre analyse ont émergé huit catégories de défis. La pénurie de personnel scolaire et l’instabilité des directions d’école et de conseils scolaires ont été analysées en profondeur. Les gestionnaires nomment leur origine et les parties prenantes impliquées, jugent de leur importance sur l’ensemble de l’organisation, citent des sources d’influence externes (ministère de l’Éducation, ordre professionnel, université, conseil scolaire) comme pouvant intervenir pour contrer la pénurie du personnel. Les actions proposées visent la valorisation du personnel, de meilleurs salaires, des formations adaptées avec de l’accompagnement, etc. Peu de gestionnaires se sentent investis quant aux possibilités de transformer l’organisation éducative pour répondre au défi.
Cultiver l’innovation, l’engagement et le leadership partagé à travers le coenseignement parent-enseignant : quelles implications pour les directions d’école ?
Authors: Ndiaye Awa , Ruminot Carolina
Published: January 2025

Les organisations éducatives sont confrontées à des défis multiples, tels que l’équité et la performance dans un environnement éducatif en constante évolution. La nécessité pour les directions d’école de repenser ces organisations est devenue évidente, comme en témoignent les réformes curriculaires. Le coenseignement parent-enseignant émerge comme une approche pédagogique novatrice et prometteuse qui renforce l’engagement, la motivation et le bien-être de tous les élèves. En 2022-2023, la direction d’une école secondaire franco-ontarienne, 80 élèves, 8 parents et un enseignant ont été impliqués dans un projet pilote. Cette étude vise à explorer l’influence du coenseignement parent-enseignant sur le leadership pédagogique d’une direction d’école. Plus précisément, elle cherche à comprendre dans quelle mesure cette collaboration pourrait transformer les pratiques de leadership des directions d’école, ainsi que son organisation et fonctionnement. Basées sur un modèle de recherche-développement et utilisant le journal de bord comme méthode de collecte de données, les analyses qualitatives révèlent la nécessité pour la direction d’adopter un leadership pédagogique engagé et facilitateur. Ce type de leadership favorise une meilleure communication, collaboration, et compréhension mutuelle au sein de la communauté éducative. Le coenseignement parent-enseignant possède le potentiel de renforcer le partenariat entre l’école et les familles, tout en dynamisant la vitalité de l’école francophone.
Les compétences interculturelles : un outil nécessaire à l’éducation francophone d’aujourd’hui
Authors: Zoghbi Sara
Published: January 2025

L’objectif de cet article est de mettre en avant les réels besoins des enseignantes et des enseignants dans un établissement multiculturel qui enseigne un programme scolaire francophone à une population plurilingue. Pour ce faire, l’article découle d’un travail de recherche portant sur l’adaptation des pratiques éducatives françaises dans un contexte francophone, mené en 2021 dans un pays identifié ici par la lettre « X ». La recherche s’appuie d’abord sur un cadre théorique qui définit le métier d’enseignante et d’enseignant comme un travail d’experte et d’expert, pour ensuite expliciter l’idée de pédagogie interculturelle. La méthodologie de recherche adoptée est mixte. Elle permet d’identifier les préoccupations du corps enseignant tout en clarifiant les éléments essentiels à intégrer dans la création de formations adaptées. L’objectif ultime est de garantir la capacité des enseignantes et enseignants à exercer leur métier au sein d’une population plurilingue et pluriculturelle, tout en minimisant les conflits culturels.
Theoretical Possibilities of Controlling the Cooling Rate in the Heat Treatment of Cast Iron with Water Mist
Authors: Stręk Piotr
Published: January 2025

The goal of the cooling procedure after austenitizing in the austempering heat treatment process applied to ausferritic ductile iron (ADI) castings is to rapidly reduce the temperature throughout the casting volume to the temperature range of the process window in which the proper metal matrix structure is formed. The lower limit of this range must be higher than the temperature at which the martensitic transformation starts. The upper limit is selected to eliminate the possibility of diffusion decomposition of austenite while holding castings at austempering temperature. Most often in heat treatment practice, salt baths are used for this purpose. Such a solution makes it possible to realize in one device both the procedure of cooling down to a given temperature and the procedure of isothermal heat treatment at this temperature. Unfortunately, the presence of molten salt in the process equipment has a very unfavorable impact on working conditions and ecology. The purpose of this research is to analyze the possibility of replacing the salt bath cooling procedure in the manufacturing process of ADI castings with a water mist spray cooling procedure on the surfaces of the heat-treated casting. If such cooling is effective, subsequent procedures of heat treatment operations can be carried out with traditional furnace equipment without the use of molten salt, which will clearly improve the environmental performance of the enterprise. The article, using analytical and numerical methods, analyzes the possibility of cooling objects made of cast iron with the help of a high-efficiency heat receiver such as water mist spraying. The limiting conditions for carrying out the process for the assumed cooling curve were considered. It was proposed to use a PID controller realizing the function of controlling the intensity of water mist spray, which corresponds to the intensity of the heat flux received from the heat-treated casting. The theoretical analysis carried out allows us to conclude that water mist cooling according to the assumed cooling curve is practically feasible.
Global transcription factors analyses reveal hierarchy and synergism of regulatory networks and master virulence regulators in Pseudomonas aeruginosa
Authors: Huang Jiadai , Sun Yue , Chen Fang , Li Shumin , Han Liangliang , Li Jingwei , He Zhe , Hua Canfeng , Yao Chunyan , Li Tianmin , Lu Beifang , Chang Yung-Fu , Deng Xin
Published: January 2025

The transcription factor regulatory network in
Pseudomonas aeruginosa
is complex and involves multiple regulators that respond to various environmental signals and physiological cues by regulating gene expression. However, the biological functions of at least half of its 373 putative transcription factors (TFs) remain uncharacterised. Herein, chromatin immunoprecipitation sequencing (ChIP-seq) was used to investigate the binding sites of 172 TFs in the
P. aeruginosa
PAO1 strain. The results revealed 81,009 significant binding peaks in the genome, more than half of which were located in the promoter regions. To further decode the diverse regulatory relationships among TFs, a hierarchical network was assembled into three levels: top, middle, and bottom. Thirteen ternary regulatory motifs revealed flexible relationships among TFs in small hubs, and a comprehensive co-association atlas was established, showing the enrichment of seven core associated clusters. Twenty-four TFs were identified as the master regulators of virulence-related pathways. The pan-genome analysis revealed the conservation and evolution of TFs in
P. aeruginosa
complex and other species. A Web-based database combining existing and new data from ChIP-seq and the high-throughput systematic evolution of ligands by exponential enrichment was established for searching TF-binding sites. This study provides important insights into the pathogenic mechanisms of
P. aeruginosa
and related bacteria and is expected to contribute to the development of effective therapies for infectious diseases caused by this pathogen.
Birds migrate longitudinally in response to the resultant Asian monsoons of the Qinghai-Tibet Plateau uplift
Authors: Zhang Wenyuan , Gu Zhongru , Chen Yangkang , Zhang Ran , Zhan Xiangjiang
Published: January 2025

The uplift of the Qinghai-Tibet Plateau is one of the greatest geological events on Earth, pivotally shaping biogeographic patterns across continents, especially for migratory species that need to overcome topographical barriers to fulfil their annual circle. However, how the uplift influences animal migration strategies remains largely unclear. We compare the current flyways of 50 avian species migrating across the plateau with those reconstructed before the uplift as a counterfactual. We find that the major effect of the plateau uplift is changing avian migratory directions from the latitudinal to the longitudinal. The monsoon system generated by the uplift rather than the high elevation
per se
shapes those changes. These findings unveil a mechanism that an important global geological event has influenced biogeographic patterns of migratory birds, yielding testable hypotheses for how observed avian distributions emerge.
Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL
Authors: Luo Dong , Zheng Jing , Lv Shuning , Sheng Ren , Chen Maorong , He Xi , Zhang Xinjun
Published: January 2025

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ligases ZNRF3 and RNF43 promote the endocytosis and degradation of FZD receptors to inhibit Wnt signaling, and their function is antagonized by R-spondin (RSPO) proteins. However, the dependency of RSPO-ZNRF3/RNF43-mediated FZD endocytosis and degradation on Wnt stimulation, as well as the specificity of this degradation for different FZD, remains unclear. Here, we demonstrated that Wnt specifically induces FZD5/8 endocytosis and degradation in a ZNRF3/RNF43-dependent manner. ZNRF3/RNF43 selectively targets FZD5/8 for degradation upon Wnt stimulation. RSPO1 enhances Wnt signaling by specifically stabilizing FZD5/8. Wnt promotes the interaction between FZD5 and RNF43. We further demonstrated that DVL proteins promote ligand-independent endocytosis of FZD but are dispensable for Wnt-induced FZD5/8 endocytosis and degradation. Our results reveal a novel negative regulatory mechanism of Wnt signaling at the receptor level and illuminate the mechanism by which RSPO-ZNRF3/RNF43 regulates Wnt signaling, which may provide new insights into regenerative medicine and cancer therapy.
Erosion under turbulent slurry flow: applicability of ultrasound flow visualization for study of erosive wear
Authors:   , Araya Araya Millaray Rocío Andrea
Published: January 2025

El estudio de la erosión causada por el flujo turbulento de pulpas es crucial para el diseño y operación de sistemas de flujo multifásico, así como para predecir su confiabilidad y vida útil. Esta investigación explora la capacidad de la Velocimetría por Imágenes de Partículas por Ultrasonido (UPIV) para determinar los campos de flujo y los parámetros de impacto de partículas proyectadas desde un flujo turbulento de pulpa sobre una superficie objetivo en movimiento utilizando dos planos de observación, con la intención de contribuir a la mejora, validación y desarrollo de los actuales modelos de erosión. Se emplea una configuración de slurry pot, utilizando dos transductores montados en el exterior, perpendiculares entre sí, a tres niveles de velocidad rotacional, correspondientes a velocidades tangenciales nominales en la superficie de la muestra expuesta de 2.5, 3.0 y 3.5 m/s. Se examina la aplicabilidad del método para obtener parámetros del impacto de partículas. Se realiza un análisis comparativo de los resultados determinados por UPIV e inspección de la morfología de marcas de desgaste para su validación. Los principales resultados indican que las velocidades radiales son consistentes entre las mediciones de los dos planos de observación. Se obtienen tres componentes del vector de velocidad de impacto, no para impactos de partículas individuales sino como información estadística, y se formula un modelo de equivalencia de prueba de dureza (HTE model). Se comprueba que el método UPIV proporciona datos relevantes para medir y modelar el desgaste erosivo de materiales dúctiles expuestos al desgaste por lodos. Sin embargo, se debe tener en cuenta que los resultados de los parámetros calculados por análisis inverso de marcas de desgaste dependen significativamente del modelo utilizado y que no todos los impactos observables por ultrasonido producen marcas de desgaste.
Relación entre las ACEs de los cuidadores, ACEs infantiles y sintomatología emocional y conductual infantil: Efectos de una intervención basada en videofeedback para cuidadores
Authors:   , Gutiérrez Huamani Melany Mariana
Published: January 2025

La literatura ha estudiado que las Experiencias Adversas en la Infancia (ACEs) de los cuidadores puede influir negativamente sobre la parentalidad. A su vez, se ha demostrado que la salud mental de los/as niños/as, especialmente a nivel emocional y conductual, puede verse afectada por las ACEs de los cuidadores y de los/as mismos niños/as. Los primeros dos primeros objetivos del presente estudio describen la relación entre ACEs de los/as niños/as, ACEs de los cuidadores y sintomatología emocional y conductual infantil; el tercer objetivo consistió en analizar el efecto de una intervención basada en videofeedback, a nivel conductual y emocional en niños y niñas entre 2 y 5 años en Chile, considerando las experiencias adversas tempranas de los infantes y la de sus cuidadores. Entre los principales hallazgos, se observó que un mayor puntaje en experiencias adversas tempranas de los cuidadores, medido a través del ACE-IQ, se asocia con un mayor puntaje en las experiencias adversas de los/as niños/as, evaluadas mediante el PEARLS. A su vez, se observó que los/as niños/as con un mayor número de experiencias adversas tempranas presentaron más problemas de salud mental. En cuanto a la efectividad de la intervención, los resultados basados en el puntaje del SDQ mostraron que la intervención completa de 9 sesiones tuvo un efecto significativo en la reducción de la sintomatología emocional y conductual de los/as niños/as. Asimismo, al considerar las experiencias adversas de los/as niños/as se observó que la intervención completa fue efectiva en niños/as que no habían experimentado alguna experiencia adversa.
Adquisición de unidades verbales en niños/as que desarrollan el chedungun en la región del Biobío
Authors: Miranda Espinoza Jonathan , Vivar Vivar Pilar
Published: January 2025

Durante los últimos años se ha priorizado el estudio de la adqui-sición de lenguas indoeuropeas sobre las indígenas. La UNESCO (2020) ha declarado la década del 2022 – 2032 como el mayor tiempo de declive en su documentación, por lo tanto, existe un llamado urgente a la investigación y registro de la adquisición en lenguas indígenas en el mundo (Kelly et al., 2015). Este estudio explora la adquisición de los verbos de dos niños/as que adquieren el chedungun como primera lengua en la región del Biobío (VIII). Específi-camente, nos hemos propuesto: a) Describir el orden de adquisición de ver-bos b) Comparar la adquisición de los verbos según el modo y el tiempo. Esta investigación sigue un diseño longitudinal de evolución de grupos o cohort. Este proceso es in situ con participación directa de las familias y contempla el registro periódico de los niños/a durante un año. Dentro de los resultados, se evidencia una adquisición sistemática de verbos, en ambos niños/as mapuche.
Respecto a Javiera entre los 1;6 y 2;6 años presenta verbos simples de tiempo presente y pasado y marcas morfológicas de modos indicativo e imperativo. En el caso de Mateo entre 4;6 a 5;6 años, presenta verbos más complejos con tiempos verbales presente, pasado y futuro y modos imperativo, indicativo y subjuntivo. Sin embargo, aunque Mateo presente estructuras gramaticales más complejas que Javiera, aún faltan algunos elementos gramaticales para tener un desempeño lingüístico similar a la de un hablante adulto del chedungun.
Physico–Chemical Characterization of Camel (Camelus dromedarius) Milk as Influenced by Parities and Seasons under Pastoral Production System in Katsina State, Nigeria
Authors: M. I. Ghude, , H. B. Mohammed, , N.A. Alassan, , H. A. Alkali, , B. Bello, , I. R. Muhammad, , S. A. Maigandi,
Published: January 2025

The study was conducted in order to come-up with the various physico–chemical characterization of camel (Camelus dromedarius) milk under pastoral production system in Katsina State, Nigeria. It was conducted using twelve (12) lactating camel cows under three different parity levels (1, 3 and 5). The feeding and watering regimes of the camels were the same and all the animals were managed under pastoral production system. The animals for the study were carefully examined before the selection especially for calving and health status. Milk samples collected were studied under the guide of various prescribed methods using local kits available. Results obtained indicated higher values of acidity (0.35%) and specific gravity (1.008%) both under parity five in hot dry season followed by titerable acidity with higher values (0.015g) in parity three under cold dry season. Vitamin C was higher (4.71 mg/100ml) in parity five under wet season respectively. In conclusion, the study also confirmed that camel milk is full of evenly balanced nutritional constituents that plays a variety of roles despite the level of management, feeding and watering regimes.
Serum Lactic Acid: A Predictor of Septic Shock in Childhood Cancers with Febrile Neutropenia in a Tertiary Care Hospital in Bangladesh
Authors: Rahman Rezwana , Rahman ATM Atikur , Fysal Md. Owashak , Akther Farah , Paul Soumitra , Rahman Md. Moklesur , Hasan Md. Mehedi
Published: January 2025

Background: Febrile neutropenia (FN) is a common and life-threatening complication in children undergoing treatment for cancer, often leading to septic shock. Early identification of septic shock is critical. Serum lactic acid levels have emerged as a potential biomarker for predicting septic shock. This study aimed to determine the implications of serum lactic acid levels as a predictor of septic shock in childhood cancer patients with febrile neutropenia.
Methods: This cross-sectional study was from June 2023 to July 2024. One hundred pediatric oncology patients with neutropenia who were admitted to the Department of Pediatric Hematology and Oncology at Bangabandhu Sheikh Mujib Medical University (BSMMU) were enrolled in the study. Clinical examinations and laboratory investigations were conducted for all participants, and the relevant information was recorded. Data were analyzed using SPSS 24.0.
Results: Shock patients exhibited significantly higher initial serum lactic acid levels (3.52±0.81 mg/dl) compared to non-shock patients (1.93±0.75 mg/dl). The ROC curve analysis yielded an AUC of 0.934, with a sensitivity of 100.00%, specificity of 81.6%, and a cut-off value of 2.50 mg/dl. The diagnostic performance test demonstrated a PPV of 63.16%, NPV of 100.00%, and overall accuracy of 86.00%.
Conclusion: This study demonstrates the potential utility of serum lactic acid levels as a predictive biomarker for identifying febrile neutropenic patients at risk of developing septic shock within 48 hours. Serum lactic acid level >2.5 mmol/L could be considered as a threshold for early risk stratification.