bluuebunny/crossref_metadata_2025 huggingface dataset:
Unlocking the Whitening Potential: Investigating the Benefits of Solanum lycopersicum. L Ethanol Extract on Teeth Discoloration
Authors: Priyambodo R , Liasari Ira , Asrinah Nur , Lesmana Hans , Sitanaya Rini , Supriatna Agus
Published: November 2024

Background and Aims:
Self-appearance, including clean and white teeth, impacts confidence. Natural products like tomatoes, rich in vitamin C and lycopene, are promising teeth-whitening agents. This study aims to explore the effects of tomato extract on teeth whitening by comparing different toothpaste formulations.

Methods:
Experimental laboratory methods were employed, utilizing a sample of 20 human premolar teeth. We processed the tomatoes by washing, drying, grinding, macerating with 96% ethanol, and evaporating them to obtain a concentrated form. We incorporated different concentrations of tomato extract (5%, 7.5%, and 10%) into toothpaste formulations. Then, we compared it with negative control and a commercial toothpaste brand (Zact). The toothpaste was applied twice daily for 14 days, followed by rinsing and placement in an artificial saliva solution. Teeth colour change was measured using the shade guide. Statistical analyses, including the Kruskal- Wallis and Dunn-Bonferroni tests, were conducted to determine the significance of colour changes.

Results:
Based on the results, the study found that tooth brightness increased with the concentration of tomato extract in each formula, with higher concentrations leading to more significant improvements.

Conclusions:
This research provides valuable insights into the potential of tomato extract as a natural teeth-whitening agent. Furthermore, the practical applications and potential for commercialization are promising, suggesting that tomato extract could be developed into a widely used product in the dental care industry
Advancements in Health Informatics: A Literature Review of Saudi Arabia's Healthcare Digital Transformation
Authors: Mohammed Rafiuddin , Albarrak Ahmed
Published: November 2024

Health informatics in Saudi Arabia has experienced significant growth and development over the past few decades, driven by the country’s commitment to modernizing its healthcare system and improving the quality of healthcare services. Saudi Arabia’s commitment to digital transformation in healthcare positions it for continued progress in the field of health informatics. This literature review explored the key aspects of health informatics in Saudi Arabia, including the adoption of electronic health records (EHRs), the expansion of telemedicine, the establishment of health information exchange (HIE) networks, healthcare analytics, infrastructure development, regulations, education and training, research and innovation, challenges, public health initiatives, and patient engagement. With a tech-sawy population, government commitment, and rapid adoption of digital health technologies, Saudi Arabia is well-positioned for significant growth in health informatics. This promises a bright future for healthcare in the country, marked by improved patient care, enhanced healthcare quality, and better public health outcomes.
Subtalar Arthroereisis for Symptomatic Flexible Flatfoot in Adolescents: A Prospective Study of 26 Feet
Authors: Alkhatatba Mohammad , Essa Suhaib , Khatatbeh Moawiah , Radaideh Ahmad , Audat Hamzeh , Younes Ahmad , Alrawashdeh Mutaz , Abualadas Jehad , Obeidat Naser , Omari Jamal , Anaqreh Yazan
Published: November 2024

Background: Flexible flatfoot is a normal finding in infants and the arch is shaped spontaneously in most children before the age of 10 years. Flexible flatfoot is a common deformity in both adolescent and adult populations. Objective: This prospective study aims to assess the functional and radiological outcomes of subtalar arthroereisis in adolescent patients with symptomatic flexible flatfoot. Methods: This is a prospective study and included 26 feet in 19 patients who underwent subtalar arthroereisis for symptomatic flexible flatfeet deformity. Preoperative and postoperative functional assessment based on the American Orthopedic Foot and Ankle Society (AOFAS) hindfoot scale. Radiographic parameters included preoperative and postoperative Kite`s angle, talonavicular coverage angle, Anterior-Posterior talo-1st metatarsal angle, Meary`s angle, talar declination angle, calcaneal inclination angle and lateral talocalcaneal angle. Results: The mean follow-up period was 22.5±9.4 months and the mean preoperative AOFAS score was 54.6±6.0, while the mean AOFAS score at the last follow-up visit was 86.3±3.9 (P<0.001).The mean preoperative and postoperative radiological measurements were 19.0°±8.2° and 7.4°±3.9° for the AP Talo-1st metatarsal angle (P<0.001); 23.6°±9.1° and 8.0°±4.0° for talonavicular coverage angle (P<0.001); 35.4°±3.7° and 24.1°±3.4° for Kite`s angle (P<0.003); 22.4°±6.1° and 7.5°±3.7° for Meary`s angle (P<0.001); 41.0°±4.4° and 25.2°±7.1° for talar declination angle (P<0.001); 13.5°±3.7° and 21.3°±3.6° for calcaneal inclination angle (P<0.001) and 52.4°±7.2° and 42.9°±4.8° for lateral talocalcaneal angle (P<0.041) respectively. Conclusion: Subtalar arthroereisis is an effective and minimally invasive procedure that showed clinical and radiological improvement for symptomatic flexible flatfoot in our study group.
YANGI O‘ZBEK SHE’RIYATIDA OLAM BADIIY MANZARASINI GUL TIMSOLLARI ORQALI IFODALASH POETIKASI
Authors: Oʻroqova Nafosat Yoriyevna
Published: November 2024

Maqolada zamonaviy she’riyatda olamning badiiy manzarasini floristik obrazlar orqali ifodalash poetikasiga diqqat qaratilgan. Shu o‘rinda, mazkur obrazlarning asosiy turlaridan biri hisoblanadigan gul timsollari badiiy adabiyotimizdagi asosiy kategoriyalardan biri ekanligiga urgʻu berilgan. Qadimda turkiy xalqlar ayrim oʻsimlik, daraxt, hayvon yoki qushlarga kult sifatida qarashgan. Ular bilan bogʻliq inonchlarga sigʻinishgan. Xalq poeziyasining ibtidoiy davrlarida, floristik va faunistik obrazlar turli xalq inonchlariga koʻra, keyinchalik esa oʻzining yashash sharoiti, tashqi tuzilishi, umumiy xarakter-xususiyatidan kelib chiqqan holda majoziy-ramziy ma’no ifodalaganligi ilmiy asoslangan. Oʻsimlik va gullarni jonli deb bilish natijasida qadimdan xalq folklorida xotin-qizlarni gulga, ayrim oʻsimliklarga qiyoslash an’anasi mavjud boʻlgan. Ular orqali xalq dilidagi dardlarini, qalb kechinmalarini yorqin ifoda eta olganligi dalillangan. Bundan tashqari, mumtoz lirik asarlarimiz xalq poeziyasidan oziqlangan holda davom ettirilgani, unda mavjud poetik obrazlar tadrijiy ravishda oʻsib borganligi yoritilgan. Insonlarning xarakter-xususiyatlari, jamiyatda hukm surgan siyosiy vaziyat, oddiy xalqning umumiy ahvoli, ularning ruhiyati, kayfiyati, alam-dardi, moddiy turmush tarzi oʻsimliklar, gullar, daraxtlar, qushlar hamda hayvonlarning poetik obrazlari orqali ramziy gavdalantirilib, badiiy maqsadga erishishga intilish kuchaygan. Zero, maqolada olam badiiy manzarasini floristik obrazlar vositasida ifodalash yoʻsinida mumtoz lirikamiz an’analariga sodiqlik bir qadar saqlanib qolganligi misollar orqali ko‘rsatilgan va H.Olimjon, E.Vohidov, J.Kamol gʻazallari asosida dalillangan. Ularning ijodida janr, obraz, she’riy san’atlar va poetik tasvir usuli masalalarida mumtoz she’riyat an’analari davom ettirilgani asoslangan. Mazkur maqolada yangi o‘zbek she’riyatida faol qo‘llanib kelinayotgan gullar obrazi yuqorida tilga olingan xususiyatlarga ko‘ra atroflicha o‘rganilgan va uning ilmiy-nazariy asoslari yaratilgan.
TADBIRKORLIK SUBYEKTLARI SAMARADORLIGINI OSHIRISHDA ZAMONAVIY TEXNOLOGIYALAR VA HISOBLASH USULLARI: INNOVATSION YECHIMLAR VA STRATEGIK YONDASHUVLAR
Authors: Toxirov Rustam Solijonovich
Published: November 2024

Mazkur maqola tadbirkorlik subyektlari samaradorligini o‘lchash va hisoblash texnologiyalari haqida batafsil ma’lumot beradi. Maqolada ROI, EBITDA kabi moliyaviy ko‘rsatkichlar hamda zamonaviy texnologiyalardan foydalanish samaradorlikni oshirishda muhim rol o‘ynashi ta’kidlanadi. Xususan, Big Data, sun’iy intellekt (AI), va bulutli hisoblash texnologiyalarining samaradorlikni oshirishdagi ahamiyati o‘rganilgan. Shuningdek, O‘zbekiston tadbirkorlik sektorida raqamli transformatsiyaning hozirgi holati va texnologiyalarni joriy qilishning biznes samaradorligiga ta’siri batafsil tahlil qilingan.
ФАКТОРЫ, ВЛИЯЮЩИЕ НА ИННОВАЦИОННОЕ РАЗВИТИЕ ПРЕДПРИЯТИЙ СФЕРЫ УСЛУГ
Authors: Насиров Дилшод Фархадович
Published: November 2024

В этом исследовании анализируются основные факторы, влияющие на инновационное развитие организаций в области услуг. Особое внимание акцентируется на внутренних и внешних детерминантах, которые способствуют или мешают внедрению инноваций в этом секторе. К числу ключевых факторов относятся технологические трансформации, господдержка, среда конкуренции, запросы и ожидания потребителей, корпоративная культура и квалификация работников. Изучаются способы адаптации компаний к изменяющимся условиям на рынке услуг и приводятся примеры удачного использования инновационных методов. Исследование акцентирует внимание на значении стратегического планирования, вложений в научные исследования и разработки, а также сотрудничества с партнерами для достижения устойчивого развития и укрепления конкурентоспособности компаний в сфере услуг.
O‘ZBEKISTONDA EKSTREMAL TURIZMNI RIVOJLANTIRISH
Authors: G‘ulomqodirova Mamura , Valiyeva Layloxon Obidjon qizi
Published: November 2024

Ushbu maqolada biz yurtimizda ekstremal turizmning bugungi holati, uning mamlakat iqtisodiyoti uchun ahamiyati va rivojlanishini qo‘llab quvvatlash uchun hal qilish kerak bo‘lgan vazifalar haqida takliflar berib o‘tamiz. Maqola O‘zbekistonda ekstremal turizmni rivojlantirish. Uning sarguzasht, sayohatlarini rivojlantirish va mamlakat uchun iqtisodiy foyda olish imkoniyatlarini yoritib beradi. Yoshlar orasida keng tarqalgan ekstremal turizm turlari va uni yurtimiz bo‘ylab keng yoyish haqida so‘z boradi va u mualliflar xulosasi bilan yakunlanadi.
“Story Telling” How prepared are female students to experience menstruation at Islamic Boarding School “X”, Riau Province?
Authors: Ismainar Hetty , Marlina Hastuti , Triana Ani
Published: November 2024

Background Menstruation is a condition of vaginal bleeding that occurs as a result of the monthly cycle. In relation to adolescent girls who are studying at Islamic boarding schools and are far from their families, there is a tendency for low levels of readiness and high anxiety. The further impact of unpreparedness for menstruation in adolescent girls can cause anxiety, psychological and pathological symptoms such as fear, inner conflict, and other disorders such as dizziness, nausea, menstrual pain and can also affect decreased studying concentration.
Objective: To listen to the stories of female students in readiness for menstruation while at the Islamic boarding school.
Method: Research design with the story telling method by listening to their experiences. The research was conduct 2-3 months. Informants consisted of 12 female students who were randomly selected with the criteria of those who had just experienced menarche, aged 11-12 years. Data collection techniques by indept interview. Thematic analysis was used in analyzing the data.
Results: The first experience of menstruation, 7 person felt shocked and anxious, 5 person hid this condition. The pain experienced, 8 person were painful and 4 person were not painful. How to use sanitary napkins, 3 person already know, 9 person do not know. There are 2 person who consume painkillers, 10 others do not.
Conclusion: The majority of informants are not ready to experience menstruation, this can be seen from anxiety, experiencing menstrual pain, not knowing how to use sanitary napkins.
Suggestion: The school needs to provide regular health education for new students about the readiness of female students during menstruation.
Art, Technology, Power After The “Age of Technical Reproduction”
Authors:   National Academy of Arts, Bulgaria, Raykov Ivo
Published: November 2024

The study problematizes whether and to what extent digital technologies significantly change the principles of power-arts-society interaction from the analog “age”. In the context of Critical Theory, French poststructuralism and contemporary studies of power-culture-technology relations, receptions of the concept of Аura from Walter Benjamin‘s philosophical essay „The work of art in the age of its technical reproducibility“ are analyzed. In this way, key themes such as the construction of history, the autonomy of art and the construction of social space are brought out.
“Stories” an Exhibition by Laura Dimitrova and Stefan Altkov
Authors:   St. Cyril and St. Methodius University of Veliko Tarnovo, Bulgaria, Konova Marieta
Published: November 2024

The text is an interpretive analysis of the artworks of the artists Laura Dimitrova and Stefan Altkov, created in the period 2022–2023 and presented in a general exhibition “Stories” in various gallery spaces in the country. The exhibition takes on a different look in each exhibition area, it is rearranged and its individual components and details are added, removed or replaced in order to achieve a spatial arrangement of the “narrative”. The artworks are characterized by a unique plastic language for each of the artists, individual preferences of means of expression and materials, but the exhibition acts as a dynamic and comprehensive work of visual arts in the spirit of postmodernism of the XXI century.
A New Model оf Intercultural Education Based оn Cultural Diversity In Secondary School: Intercultural Learning: Navigating The Multicultural Maze In Literature Instruction
Authors:   St. Cyril and St. Methodius University of Veliko Tarnovo, Bulgaria, Konstantinidou Olga
Published: November 2024

In an increasingly globalized world understanding and appreciating cultural diversity through literature has become paramount in educational settings. This paper explores the intricacies of intercultural learning within the context of literature instruction, positioning it as a crucial component in fostering global awareness and empathy among students. By examining various approaches to integrating multicultural literature into the Curriculum this study highlights the challenges and opportunities educators face in navigating the multicultural maze. It argues for a deliberate, thoughtful incorporation of diverse texts that reflect a multitude of cultural experiences, thereby promoting an inclusive, empathetic, and comprehensive educational experience. Through qualitative analysis and review of current pedagogical practices, this paper aims to provide insights and strategies for educators seeking to enhance intercultural competence and cross-cultural understanding through the medium of literature.
Classifying the Difficulties in Teaching Students in the Subject Java Programming
Authors:   St. Cyril and St. Methodius University of Veliko Tarnovo, Bulgaria, Hristova Mariya
Published: November 2024

Students experience multiple difficulties in learning the Java programming language. This report attempts to classify these difficulties based on the author's experience from the laboratory classes in the Java Programming course with the Computer Science and Software Engineering majors. The classification will help to suggest workable methods and means to overcome or at least minimize these difficulties. Observations show that the main difficulties are related to the transition from the already studied language (C++ or C#) to the new syntactic constructions and abstractions of Java, the different implementation of the key concepts and mechanisms, and the application of the object-oriented approach when solving specific tasks
Intersectional Gender Studies in Sport
Authors:   Vasil Levski National Sports Academy, Bulgaria, Angelova-Igova Boryana , Dimitrova Nevena ,   Institute of Ethnology and Folklore Studies with Ethnographic Museum, Bulgarian Academy of Sciences
Published: November 2024

The article deals with the state of research in the field of gender inequality in Bulgaria. The approach is intersectional. In recent years, in the humanities and social sciences, the so-called intersectional method of researching gender, not only in sports but in every life situation. The intersectional approach examines not only the male-female gender ratio, but also factors such as age, sexuality, ethnic and religious affiliation, and social status. An intersectional approach suggests that discrimination can be not only at the level of gender but also in terms of age, appearance, ethnicity, or sexuality, so research in this area needs to be more comprehensive.
The Museum in the Hypermodern Times: Main Tendences in the PR Communication
Authors:   St. Cyril and St. Methodius University of Veliko Tarnovo, Bulgaria, Hristova Hristina
Published: November 2024

The main tendencies and priorities in the strategical and communication management of the museums in the hypermodern times are being examined in the text. In the dynamic context of the epoch, significant changes in the public life related to the triumph of the digital technologies and the transformations in the communications and the marketing are being observed. In the large-scale processes, which comprise the separate industries and draw new perspectives in the development of the organizations from different social fields, the museum as a type of a cultural institution with a rich history, is transformed into an open territory for the new tendencies and successfully implements the tools of the digital PR whose identity is being formed and manifested in the times of the hypermodernity, which came into existence in the last quarter of the ХХ century. In the conditions of increasing competition and the growing interest towards technological innovations, the museums in a worldwide scale, apply new approaches in the communication with their diverse audience and constantly widen their integrative potential. The study is based on the theoretical formulation of the French philosopher and sociologist Gilles Lipovetsky about the hypermodern and hyperconsumerist society.
Interaction Between Teachers and Psychologists: Aspects of Managing Students with Special Educational Needs
Authors:   32nd Primary and Secondary Language School St. Kliment Ohridski, city of Sofia, Mitev Alexander
Published: November 2024

The present study introduces the results of empirical research conducted within a group of 75 teachers from all over the country who work in different types of schools and is related to their interaction and cooperation with school psychologists when working with students with Special educational needs, their personal awareness of Attention Deficit and Hyperactivity Disorder Syndrome, their willingness to pursue further professional development and training for working with students with special educational needs. The article aims to present the results of summarizing and analyzing the research data by providing systematical conclusions and recommendations.
An Integrated Web-Based Platform for Student Library and Information Sciences Education: Architecture and Implementation
Authors:   Lyuben Karavelov Regional Library – Ruse, Goranov Pavel
Published: November 2024

This paper presents an integrated web-based learning platform for library and information science students, focusing on its architecture and implementation. The platform provides capabilities for creating bibliographic records, bibliographic references, and lists, based on the MARC 21 standard for bibliographic description. Students can view bibliographic records in ISBD format, ensuring completeness and accuracy of information resources. The developed system provides an intuitive user interface and complies with modern digital learning requirements, facilitating the professional development of future librarians
The Memory of Forms When Metaphorizing in Knowledge
Authors:   St. Cyril and St. Methodius University of Veliko Tarnovo, Bulgaria, Dimitrova Hristiyana
Published: November 2024

Metaphor can be seen as a metaphysical armature when having in mind its subtlety and its contrast to the ordinary in language. Oppositionally, metaphorizing as a means is used against the well-known, repeatable, literal meanings of the common language. At the least it can be perceived as nonsense, on the contrary, it is beheld as a constitution of compound human cogitation and intellective construction. Metaphor possesses its own tradition of form which is sensed as the semantics memory it is built of. This is of importance when speaking about decoding the metaphorizing whilst interacting via dialogicity. The memory of forms in metaphorizing leads to a fictional meaning and if an alternative perusal occurs, that could only style a mistake. A metaphor is not just a substitution or “saying one thing instead of another”. Essentially, metaphor has its own being and only the literate one could use such in a way that is virtuoso-built whilst using language off the ordinary, but beyond.
„To Learn, To Study“ – The True Philosophy of Upbringing
Authors:   Prof. Dr. P. Stoyanov Medical University, Markova Ilinida
Published: November 2024

The origin of the idea of education is as old as the human race. This great antiquity in time, however, is no criterion that education is properly understood today, nor that mass consciousness can achieve it. The longevity of some elements of the cultivation of humanity may also carry a negative charge, to which attention must be directed all the more seriously. The traditional misunderstanding that the priority should be to eliminate the negative rather than to encourage positive behavior has resulted in an avalanche of moral malaise, spiritual poverty, and primitivism of action - phenomena that debase human reason and will.
The Creativity of the Artist Boris Denev for the “Our Diary” Section of the “Slovo” Newspaper from the 30’s and the early 40’s of the XX century (On the Occasion 140th Anniversary of the author’s birth)
Authors: Bratanova Bogdalina
Published: November 2024

Among the significant figures of our cultural and artistic history from the first half of the 20th century, the great Velikо Tarnovo artist Boris Denev (1883–1969) stands out – a prominent master of landscapes, of numerous military sketches, studies and countless drawings. Against the multiple and diverse fields in which he appeared during his life, his works, revealed on the pages of our periodicals published until the Second World War, remain out of the researcher’s attention today. “Slovo” newspaper (1922–1944) was among the longest-running Sofia dailies publications, with a significant role in the life of the intelligentsia. It was to it that Denev dedicated a significant part of his creative life fore more than a decade. The object of examination in the text is his writing and at the same time his artistic work for the newspaper column “Our Diary”. Boris Denev’s approach to visualizing his own literary texts is traced. The artist's work is divided into three main thematic groups: nature; war and politics. The texts, accompanied by numerous illustrations, clearly show Denеv's personal attitude to both art and various spheres of life, to which he remained not indifferent throughout his artistic career. Studying the littleknown material from the pages of the newspaper “Slovo” and highlighting parallels and interconnections in the text-image relationship would form a completely different picture of the remarkable and unique personality of the artist Boris Denev.
Etnografide Araştırmacı Katılımcı Yakınlığı Üzerine Tartışmalar ve Bir Saha Araştırması
Authors: Lordoğlu Ceren
Published: November 2024

Nitel araştırma yöntemlerini kullanan araştırmacılar için saha çalışmasında katılımcı ile kurulan yakınlık ya da uzaklık, araştırma için toplanacak verilerin niteliğini doğrudan belirlemektedir. Bu nedenle günümüzde sıklıkla kullanılan bir süreç olarak da nitelendirilebilecek etnografi gibi araştırma yöntemlerinde araştırmacı-katılımcı yakınlığı en sık tartışılan konulardan biridir. Katılımcı ile yakınlığın olmadığı bir etnografik araştırma yürütmenin imkânsızlığı ile birlikte araştırmacı-katılımcı arasındaki sınırların etik konular göz önünde bulundurularak nasıl çizileceği önemli ve tartışılan bir konu haline gelmiştir. Bu çalışmada Türkçe etnografi literatüründe oldukça az ele alınan ancak bir o kadar da merak konusu olan araştırmacı-katılımcı yakınlığının imkân ve sınırlarını tartışmak ve gerçekleştirilen saha çalışmasındaki gözlem ve deneyimler ışığında değerlendirmek amaçlanmıştır. Bu çalışmada özellikle düşünümsellik, arkadaş yakınlığı ve diyalojik kavramlarına odaklanılmaktadır. Etnografik süreçle yürütülen saha araştırmasında oto-etnografi literatürünün tartışmalarında da faydalanarak araştırmacı-katılımcı yakınlığına ilişkin sorular çerçevesinde bir değerlendirme yapılmıştır.
Potential of coastal armour units as energy dissipators to enhance the characteristics of hydraulic jumps
Authors: Chowdhury Morsaleen S , Al-Hadhrami Abdullah M S , Abdelfattah Mohammed , Al Sharji Nasra S S , Ioannou Sokrates
Published: November 2024

Energy dissipating structures are strategically positioned at the base of dam spillways to prevent riverbed erosion and safeguard downstream infrastructures. The objective of this study is to experimentally explore the potential of a novel approach involving the use of coastal structures, known as armour units, as energy dissipators. Two armor unit models were designed using AutoCAD by adopting the geometry of a wave and tetrapod, and subsequently fabricated using a 3D printer with polyactic acid (PLA) material. Using a HM 160 Hydraulic Flume, experiments were performed by simulating discharge over short-crested weir, with a sloped spillway, and generating hydraulic jumps over the armour units that were installed downstream. Inflow conditions of the jumps ranged from a Froude value (Fr1) of 1.7 to 4.0. It was observed that both the wave and tripod structures induced a ski-jump effect before the hydraulic jump, which would facilitate the transportation of sediments and minimize scour risks in practical applications. Additionally, the energy dissipation level through the jumps had improved by four-fold as the height of the ski-jump doubled. Both structures also caused a significant reduction in sequent depth and length of the hydraulic jumps, up to 40% and 50%, respectively, as compared to the classical hydraulic jump formation on a smooth bed, which may lead to a more cost-effective basin design. Overall, the findings of this research highlights the possibility of utilizing a minimal number of units for adequate energy dissipation, offering significant advantages in scenarios where mitigating flood energy in open channels is required.
Adverse events of chemotherapy in tuberculosis with multidrug resistant mycobacteria
Authors: Rodina O. V.
Published: November 2024

The review presents current information on the prevalence of multidrug-resistant tuberculosis in the world and in Russia, analyzes the literature data on adverse events of its treatment, their frequency and types, methods of prediction and prevention.
Work experience of central medical commission in Moscow tuberculosis clinic N 3 named by prof. G.A. Zakhar`in of Moscow healthcare department
Authors: Kochetkova E. A. , Danilova I. D. , Demenok I. N. , Petrova L. E. , Shibanov A. M.
Published: November 2024

At present the diagnosis of tuberculosis and its treatment features require an individual interdisciplinary approach. The analysis and mentioned clinical examples clearly demonstrate monitoring, supporting and training role of central medial commission. The review of the clinic work prove reduced incidence of hypo- and hyperdiagnosis of tuberculosis after implementation of centralized control, which promote the standardization of diagnostic algorithms.
Tuberculosis of peripheral lymph nodes – manifestation of first or second period of TB-infection?
Authors: Reshetnikov M. N. , Kalinina M. V.
Published: November 2024

Government Healthcare Department, Moscow, Russia The article describes case history of two patients with tuberculosis of peripheral lymph nodes, possible pathogenetic mechanisms for this extrapulmonary form of tuberculosis.
Problems of drug resistance of M. tuberculosis
Authors: Litvinov V. I. , Nosova E. Yu.
Published: November 2024

The review presents the latest information on the mechanisms of development of drug resistance of M. tuberculosis and methods for studying the drug sensitivity of mycobacteria
Remote support of treatment of a patient with tuberculosis with the help of a self-monitoring
Authors: Kotova, E. A. , Bogorodskaya E. M. , Istomina N. N.
Published: November 2024

The pandemic of a new coronavirus infection COVID-19 has affected almost all spheres of life in Moscow, and, first of all, the medical sector. The universally introduced self-isolation regime also has affected the organization of work with patients with tuberculosis (TB). In order to prevent penetration of COVID-19 into inpatient departments of The Moscow City Scientific and Practical Center for Tuberculosis Control, it was necessary to limit as much as possible the contacts of TB patients inside the departments and to set the minimum occupancy rate of hospital chambers, where TB patients with developed processes, combined HIV/TB infection were on long-term treatment. For the period of high alert, day hospital at home treatment was organized for TB patients without bacteria excretion, including provision of drugs, necessary manipulations and sampling of material for laboratory analysis collection accompanied by daily treatment control using remote technologies. This situation inspired the medical professionals to pay special attention to each patient receiving treatment at home. It was necessary among other things to help patients organize themselves to maintain daily regime and motivate to treatment. The self-monitoring diary, developed by The Moscow City Scientific and Practical the Moscow Department of Healthcare was one of the key tools for remote interaction with patients during the period.
Investigation of the Relationship of Values of Minimal Inhibitory Concentrations of Bedaquiline Against Isolated From Newly Detected Patients Mycobacterium Tuberculosis Strains with Their Susceptibility/Resistance to Antitubercular Drugs and Genetic Families
Authors: Peretokina I. V. , Krylova L. Yu. , Mikhailova Yu. D. , Sviridenko M. A. , Khakhalina A. A. , Safonova S. G.
Published: November 2024

The article presents the results of drug susceptibility testing (DST) for anti-TB drugs of 120 strains of Mycobacterium tuberculosis (MBT) isolated from newly detected patients with pulmonary TB before starting chemotherapy. All patients permanently resided in Moscow. DST for the main and reserve drugs revealed that MBT strains were resistant to anti-TB drugs in 50% of cases. Our study showed that bedaquiline has high anti-tuberculosis activity in vitro against sensitive and resistant MBT strains. Investigated MBT strains belonged to different genetic families, but the Beijing strains prevailed (64.2%). A comparative analysis of the results of determining the MIC values of bedaquiline concerning these MBT strains did not reveal a relationship between the results of DST of MBT for anti-TB drugs and their belonging to genetic families. According to the critical concentrations recommended by WHO, all investigated strains were identified as susceptible to bedaquiline.
The Effectiveness and the Safety of Combined Tuberculosis Treatment Regimens Using the Drug Perchlozon. Methods of Forecasting, Prevention and Elimination of Adverse Events
Authors: Ershova E. S. , Turik A. L. , Pavlova M. V. , Revjakin E. A.
Published: November 2024

The article presents the results of a randomized clinical trial to study the effectiveness of treatment of drug-resistant tuberculosis with the use of the anti-tuberculosis drug thioureidoiminomethylpyridinium perchlorate (Perchlozon, Tpp). The frequency of occurrence and the spectrum of adverse events studied. An in-depth analysis of individual adverse reactions and their causal relationship with various components of the combined treatment regimens carried out. Presented algorithms and recommendations for predicting, preventing, and correcting the most common complications of drug therapy.
The Effectiveness of Autologous Composition Based on Dendritic Cells in the Treatment of Pulmonary Tuberculosis with Extremely Drug Resistance After an Ineffective Course of Polychemotherapy
Authors: Filatov M. V. , Starshinova A. A. , Nazarenko M. M. , Zinchenko Yu. S. , Istomina E. V. , Belaeva E. N. , Landa S. B. , Burdakov V. V. , Pavlova M. V. , Yablonskiy P. K.
Published: November 2024

Despite the introduction of new anti-tuberculosis drugs, the problem of treating tuberculosis patients with a broad drug-resistant pathogen (XDR MBT) remains relevant.

Aim of the study. Тo increase the effectiveness of treatment of this category of patients using an autologous composition based on dendritic cells activated by a specific antigen.

Research materials and methods. А prospective study conducted in 2016-2019 included 52 patients, 36 (69.2%) men and 16 (30.8%) women, average age 43.2 ± 1.5 years. All patients received antituberculosis therapy in accordance with existing regulatory documents and recommendations. The main group consisted of 25 patients (48.1%) who agreed to immunotherapy with the introduction of an autologous composition with activated specific peptides ESAT-6 and SFP-10 dendritic cells against the background of anti-tuberculosis therapy. Statistical processing of the material carried out using the Statistica 10.0 application software package.

Results. In 70.0% of cases (n = 14), there were no adverse reactions to suspension administration in patients of the main group. One patient (7.2%) had a general reaction in the form of tremor, chills after the first injection. In 5 (38.7%) patients on the 8th and 9th administration, a skin reaction was noted at the injection sites in the form of a papule, with a final regression of these changes after 8 weeks. By 18– 24 months of the course, anti-tuberculosis therapy in combination with immunotherapy in the first month of treatment allowed to obtain a positive effect according to clinical, bacteriological and radiological data in 64% of cases. It was not possible to obtain this result during therapy at the previous stages of treatment. In the comparison group, a positive result achieved only in 45.5% of cases.

Conclusion. The results of the study suggest a positive effect of complex treatment with the inclusion of immunotherapy with an autologous composition based on dendritic cells in the most severe contingent of patients with pulmonary tuberculosis with broad drug resistance of the pathogen, even with an ineffective course of chemotherapy at the previous stage in 64% of cases.
IX ежегодная конференция московских фтизиатров с международным участием «95 лет борьбы с туберкулезом на благо здоровья москвичей» 2–3 сентября 2021 года
Authors: Editorial Article
Published: November 2024

.
E.N. Bellendir and His Contribution to the Study of Tuberculosis: on the 95th Anniversary of the Scientist’s Birth
Authors: Chuzhov A. L. , Ariel B. M. , Serdobintsev M. S.
Published: November 2024

The article describes the life-path of Eduard N. Bellendir (1926- 2010), his scientific methodology and the system of ideas about the pathogenesis of extrapulmonary tuberculosis, which developed over half a century of experimental study of this pathology.
The problem of adherence to treatment of hiv-infected parents and its role in preventing the development of HIV infection and tuberculosis in children
Authors: Tarasova L. G. , Saifulin M. Kh. , Chabanova O. N. , Popova N. A.
Published: November 2024

The problem of preventing HIV infection and tuberculosis in children from contact with parents suffering from these diseases is relevant because annually more than 90% of HIV-infected children become infected in utero, and in every fifth focus of tuberculosis infection in one of the parents, coinfection is detected (HIV infection and tuberculosis). The review analyzes randomized multicenter trials from 2013 to 2021 from databases of the National Library of Medicine PubMed and Elibrary. The article provides information on the effectiveness of various methods of prevention of HIV infection and tuberculosis and their combination in the antenatal and postnatal periods.
"95 years of fighting tuberculosis for the benefit of Muscovites' health." Conference abstracts
Authors: Editorial Article
Published: November 2024

.
The course of a new coronavirus infection in children with various manifestations of tuberculosis infection
Authors: Gurieva O. I. , Luginova E. F. , Prokopiev E. S. , Nikolaevа D. A.
Published: November 2024

Symptoms of COVID-19 in patients with various manifestations of tuberculosis infection do not differ from those of acute respiratory viral infection. The disease proceeds without complications, does not aggravate the course of tuberculosis infection, after three weeks the production of class G immunoglobulins to the SARS-CoV-2 virus is noted.
Non-specific bacterial and fungal infection of the respiratory tract in patients with tuberculous pleurisy
Authors: Stogova N. A.
Published: November 2024

Rationale. The fact of colonization of the respiratory tract by nonspecific microbial flora in pulmonary tuberculosis is known, but there is no data on the features of infection of the respiratory tract with nonspecific microbial and fungal flora in tuberculous exudative pleurisy (TEP).

   Purpose. To study the spectrum and antibiotic resistance of nonspecific microflora of the respiratory tract in patients with TEP.

   Materials and methods. The analysis of the results of microbiological studies of sputum and bronchial washings of 238 patients with TEP, including 162 men and 76 women aged 18 to 88 years, was carried out.

   Results. Various types of nonspecific microflora in the sputum of patients were detected by culture on nutrient media in 176 (73.95 %) of 238 patients with TEP. Only microbial flora was isolated in 54 (30.68 %), only fungal - in 59 (33.52 %) and association of microbial and fungal flora – in 63 (35.80 %) of 176 patients. The analysis showed the predominance of Streptococcus pyogenes (32.11%), Escherichia coli and Klebsiella pneumonia (11.68 % each). The microbial flora in 29.9 % of cases had DRs to broad-spectrum antibiotics, in 11.7 % to drugs with antituberculosis activity.
The epidemic situation of tuberculosis in the Admiralteisky district of St. Petersburg for the period 2018–2021
Authors: Azovcev D. Yu. , Nacharov P. V. , Fedorov S. V. , Golubkin A. A.
Published: November 2024

Introduction. Analysis of the incidence of tuberculosis and its results are the basis for planning the activities of anti-tuberculosis dispensaries.

Purpose. Study and analysis of tuberculosis incidence rates for the period from 2018 to 2021 in the Admiralteisky district of St. Petersburg.

Material and methods. Data from registration forms on the incidence of tuberculosis, as well as information from reports on the incidence of tuberculosis in St. Petersburg and the Russian Federation. The analysis used methods for calculating incidence and prevalence, adopted in phthisiology, and a method for assessing the structure of incidence with the calculation of shares.

Results. In contrast to the data for St. Petersburg and the Russian Federation, in the Admiralteysky district of St. Petersburg, there is an increase in the incidence in 2019–2021. At the same time, in 2021, there is a decrease in the prevalence of tuberculosis compared to 2018. Among newly diagnosed patients, there is an increase in the proportion of patients with a positive HIV status and the proportion of female patients.
Krása spasí svet. K prameňom estetiky v náboženskej filozofii Vladimira S. Soloviova
Authors:   Slavistický ústav Jána Stanislava SAV, v.v.i., Dolný Ján
Published: November 2024

The essay traces the idea of beauty in the life and work of Vladimir S. Soloviev, the Russian religious philosopher, from his mystical experience of Sophia the Divine Wisdom and the place of beauty in his philosophical system. It attempts, furthermore, to illumine the biblical inspiration in Soloviev’s own interpretation of his mystical experience and his philosophical reflection on beauty.
The obligation of the trust company to pay management fees in the collective building
Authors:   Korean Association of Aggregate Building Law, Oh Sang Min
Published: November 2024

I think it rather distorts the purpose of the counterpower of trust registration to interpret that the trustee can counter a third party by giving the agreement on the internal reimbursement relationship to prevent temporary expenditure from his or her own account even the powerful effect of the counterpower of trust registration. I hope that a Supreme Court ruling will be made one step further in the future regarding the counterpower of trust registration.
La diferencia de trato entre jueces federales y los jueces de estados federados en cuanto a la posibilidad de aplazamiento de la edad de jubilación se basa en la pertenencia a una categoría profesional y, por tanto, no constituye una discriminación directa por razón de edad prohibida por la Directiva 2000/78/CE.
Authors: García Romero Belén
Published: November 2024

Prohibición de las discriminaciones por razón de la edad. Edad de jubilación obligatoria. Legislación nacional que excluye cualquier aplazamiento de la jubilación de los jueces federales. Posibilidad de que funcionarios federales y jueces de los estados federados soliciten el aplazamiento de la jubilación. Diferencia de trato en función de la pertenencia a una categoría socio profesional o del lugar de trabajo.

Prohibition of discrimination on grounds of age. Mandatory retirement age. National legislation precluding any postponement of retirement of federal judges. Possibility for federal civil servants and state judges to apply for postponement of retirement. Difference in treatment according to membership of a socio-professional category or place of work.
Los pluses por trabajo nocturno o festivo ante las vacaciones funcionariales.
Authors: Sempere Navarro Antonio V.
Published: November 2024

La prestación de servicios profesionales en festividades o periodos nocturnos suele generar el derecho al cobro de determinados complementos o "pluses". Se discute si esas compensaciones poseen repercusión cuando se trata de abonar el salario durante los permisos, vacaciones y situaciones análogas. Peculiaridad del caso la constituye que quien reclama es un funcionario de la Policía Municipal. La Corporación a que pertenece entiende que se trata de compensaciones extraordinarias, en función de la especial actividad desempeñada, pero sin repercusión en el abono por otros conceptos. La sentencia comentada declara el derecho del demandante a percibir la retribución por días festivos y nocturnidad durante los períodos de vacaciones, situaciones de incapacidad temporal, días de libre disposición y demás permisos retribuidos. Asimismo, declara que los efectos retroactivos del anterior pronunciamiento se extienden al abono de las cantidades correspondientes a los cuatro años inmediatamente anteriores a la fecha de su solicitud inicial.

Article 82.3 of the Workers' Statute (ET) allows companies in difficulty to disapply part of the content of the collective agreement, but makes this conditional on the achievement of a collective agreement or on the decision of an arbitration award. In the case raised, however, the employer promotes and reaches individual agreements with its staff. The result is that both wages and contribution bases suffer significant decreases. The General Treasury of the Social Security (TGSS) is the one who claims from the company the payment of the contribution differences (not prescribed) and the company warns that this body does not have standing to do so and that, in addition, it is up to the social jurisdiction to rule on the matter. However, STS-CONT 1235/2024 of 9 July considers that the Social Security Administration can carry out a control of legality from the perspective set out above and that the discussion on its correctness is the responsibility of the Courts and Tribunals of the Contentious Order. In view of the evidence that the mandatory procedures to carry out the 'unhooking' have not been complied with, the judgment commented on declares its lack of effects and the dismissal of the lawsuit filed by the company.
Requisitos de la comunicación escrita de extinción del contrato de trabajo por causas objetivas de carácter económico.
Authors: Preciado Domènech Carlos Hugo
Published: November 2024

Contenido exigible de la carta de despido por causas económicas para informar al trabajador y permitirle una defensa adecuada.

Required content of the dismissal letter for economic reasons to inform the worker and allow him an adequate defense.
¿Quién fija y cómo se fija el 'dies a quo' del permiso retribuido del artículo 37.3.b) del ET?
Authors: Areta Martinez María
Published: November 2024

La SAN-SOC núm. 102/2024, de 12 de septiembre, estima la demanda de conflicto colectivo interpuesta por los sindicatos CC.OO., CSIF y UGT para impugnar la instrucción interna que las empresas demandadas han adoptado con el fin de ajustar el régimen convencional de permisos tras la reforma del artículo 37.3.b) del ET operada por el Real Decreto-ley 5/2023. La Sala declara que, a falta de previsión en convenio colectivo, el inicio del cómputo del permiso del artículo 37.3.b) del ET no tiene por qué coincidir obligatoriamente con el día del hecho causante (si este es laborable), ni con el primer día laborable siguiente al del hecho causante (si este no es laborable), tal y como establece la instrucción interna impugnada. La Sala dictamina que, a falta de previsión convencional, la persona trabajadora es quien ha de fijar el 'dies a quo' del permiso en función de sus posibilidades de conciliación, y siempre que sea un día: 1) laborable, 2) a partir del hecho causante (no antes), y 3) en el que persista el hecho causante.
Spiritual education and successful aging: A spiritual dialogue
Authors: Shih Yi-Huang , Ku Min-Sheng , Tseng Shiuan-Yu , Chiang Yu-Ming , Lin Jason Cong
Published: November 2024

Most people endeavor to prolong their lives and hope for a healthy old age, indicating that successful aging is extremely important for older adults. This article explored how spiritual education can enhance successful aging for older adults and develop a spiritual dialogue between them. The researchers used documentary analysis methods to analyze the successful aging methods for older adults. The successful aging methods outlined for older adults are as follows: (1) developing a sense of meaning and purpose; (2) making sense of life experiences; (3) emphasizing the importance of connection; (4) enhancing resilience; (5) enhancing life satisfaction; (6) encouraging a holistic view of well-being. The discussion in this article can expand approaches to successful aging methods for older adults.