bluuebunny/crossref_metadata_2025 huggingface dataset:
PENINGKATAN AKTIVITAS BELAJAR IPS MELALUI PENERAPAN STRATEGI BERMAIN PERAN PADA SISWA KELAS VIII SMP NEGERI 1 KERUAK
Authors: Jamiluddin Jamiluddin , Purnawati Purnawati
Published: June 2022

Tujuan penelitian ini adalah untuk meningkatkan aktifitas belajar Mata Pelajaran IPS pada siswa kelas VIII B SMP Negeri 1 Keruak Kabupaten Lombok Timur dengan menggunakan strategi “Bermain Peran”.

Penelitian Tindakan Kelas ini dilaksanakan dengan menggunakan dua siklus, siklus 1 terdiri dari 2 kali pertemuan dan siklus 2 terdiri dari 1 kali pertemuan dengan jumlah siswa 40 orang. Data dalam penelitian ini berupa kegiatan guru, aktivitas belajar siswa, dan respon siswa dalam kegiatan belajar mengajar. Pengumpulan data dalam penelitian ini menggunakan observasi/pengamatan, angket, wawancara, catatan lapangan dan dokumentasi. Analisa data dalam penelitian ini dilakukan secara analisis kualitatif.

Hasil penelitian menunjukkan bahwa, kegiatan pembelajaran yang dilakukan oleh guru dapat dirumuskan sebagai berikut : Perencanaan pembelajaran, ada peningkatan dari 70% pada siklus I menjadi 80 % pada siklus II. Sedangkan pelaksanaan pembelajaran yang dilakukan oleh guru juga mengalami peningkatan dari 80 % pada siklus I menjadi 95 % pada siklus II. Aktifitas belajar siswa mengalami peningkatan, pada siklus I sebesar 67%,  menjadi  83 %, dalam siklus II. Sedangkan respon siswa terhadap kegiatan belajar mengajar dapat diuraikan sebagai berikut : kualifikasi yang menyatakan tidak senang sudah tidak ada, baik pada siklus I maupun pada siklus II. Sedangkan yang menyatakan kualifikasi kurang senang menunjukkan penurunan dari 6 siswa (15 %) pada siklus I, menjadi 2 siswa ( 5%) pada siklus II.  Kualifikasi yang menyatakan senang tidak mengalami kenaikan dari 25 siswa (62,5 %) pada siklus I, menjadi 25 siswa (62,5 %) pada siklus II.  Kualifikasi yang menyatakan senang sekali mengalami kenaikan dari 9 siswa (22,5%) pada siklus I, menjadi 13 siswa (32,5%) pada siklus II. Hipotesis tindakan yang menyatakan bahwa “jika strategi ‘Bermain Peran’ digunakan dalam pembelajaran mata pelajaran Mata Pelajaran IPS, maka aktifitas belajar siswa kelas VIII SMP Negeri 1 Keruak, Kabupaten Lombok Timur akan meningkat”, dapat diterima.
PROBLEMATIKA REMAJA (USIA 13-18 TAHUN) DI LINGKUNGAN NURUL YAQIN KELURAHAN PEJERUK KEBON SARI KECAMATAN AMPENAN
Authors: Mas'ad Mas'ad , Wa Arif , Fatriani Emilia
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui 1) Ada berapa Macam kenakalan remaja, 2) faktor penyebab kenakalan remaja dan 3) upaya yang dilakukan untuk mengatasi kenakalan remaja pada anak usia 13-18 tahun di Lingkungan Nurul Yaqin. Manfaat Penelitian ini adalah 1.Manfaat Teoritis, Hasil penelitian ini diharapkan dapat menambah wawasan pengetahuan bagi mahasiswa dan orang tua tentang tingkat kenakalan remaja. 2.Manfaat Praktis, Manfaat bagi pemerintah Hasil penelitian ini dapat dijadikan sebagai langkah penentu bagi pemerintah terutama pemerintah setempat.

Metode Penelitian yang diajukan dalam penelitian ini adalah Kulialitaif , Informannya sebanyak 12 orang, adapun cara penentuan informan dengan menggunakan purposive sampling, macam-macam Informan adalah Informan biasa dan Informan kunci.  Penelitian ini menggunakan dua sumber data yaitu sumber data Primer dan Sumber data Sekunder, adapun tehnik pengumpulan data menggunakan tehnik observasi, wawancara dan dokumentasi, Intrumen penelitian ini adalah Tehnik analisa data yang menggunakan reduksi data, Penyajian data dan verifikasi data. Hasil peneliatian ini adalah: 1. macam-macam kenalan remaja di lingkungan nurul yaqin adalah : a. Tawuran, dan b. Balapan Liar. 2. Penyebab terjadinya kenalan remaja di lingkungan Nurul Yaqin a. Kurangnya perhatian orang tua, b.Pengaruh lingkungan pergaulan bebas. 3.Upaya yang dilakukan untuk mengatasi kenalan remaja di lingkungan Nurul Yaqin adalah a.kedua orang tua dapat membina dan mengembangkan kepribadian dengan baik. b. menjaga keharmonisan dalam keluarga agar anak-anak merasa senang berada dalam keluarga dan merasakan suasana dalam rumah damai, tenang dan nyaman. Dan sangat diharapkan para orang tua membimbing anak sedini mungkin ke arah hidup yang sesuai dengan ajaran agama.
KENDALA DAN KENDALI PENGUASAAN BAHASA ASING DI MADRASAH
Authors: Sribagus Sribagus
Published: June 2022

It is assumed that Arabic is the  language mainly used at Madrasah.  It turns to be the other way around – hardly any teacher uses Arabic communicatively as the classroom language instruction, and hardly any student actively speaks in it fluently outside the classroom.  Teachers teach traditionally, applying “Learning System” which brings about memorization of language codes/rules and vocabulary enrichment.  Using language communicatively is beyond the intended target as stated in the curriculum.  The alternative solutions are the changing of teaching and learning method from Learning to Acquisition, and providing the language input from the early start of class activity.
PEMBELAJARAN MAHARAT AL-KALAM DALAM BAHASA ARAB
Authors: Purwana Wira
Published: June 2022

Tulisan ini menginformasikan tentang Pengajaran Keterampilan Berbicara dalam Bahasa Arab  pada semua tingkatan sekolah. Secara jelas diakui bahwa keterampilan menyimak menempati urutan awal menurut prioritas, disusul oleh keterampilan berbicara, kemudian membaca dan terakhir menulis.Tulisan ini juga  menginformasikan  sistimatika  pelaksanaan  pengajaran keterampilan berbicara dalam bahasa Arab yang diawali pemilihan/pengorganisasian materi, jenis-jenis kegiatan komunikatif, pre-teaching Plan (Rencana Penyajian Materi), Demonstration/mendemonstrasikan percakapan dan Role  Plays/main peran yaitu menulis naskah yang dikerjakan secara berkelompok baik yang dipersiapkan dalam kelas maupun di luar kelas (di luar jam kuliah), seterusnya secara bergilir diminta memainperankan tugasnya di depan kelas. Informasi pada tulisan ini diharapkan dapat menjadi bahan perbandingan terhadap apa yang telah dilaksanakan atau sementara dilaksanakan pada pengajaran keterampilan berbicara dalam bahasa Arab.
DAMPAK PERSEPSI SISWA TENTANG KONDISI EKONOMI KELUARGA TERHADAP MOTIVASI MELANJUTKAN PENDIDIKAN KE PERGURUAN TINGGI DI KALANGAN SISWA MADRASAH ALIYAH PUTRA AL-ISLAHUDDINY
Authors: Hizam Ibnu
Published: June 2022

Penelitian ini dilakukan pada siswa Madrasah Aliyah Putra Al-Islahuddinydengan memadukan pendekan kualitatif dan kuantitatif. Adapun obyekkajian dalam penelitian ini yakni melihat kondisi perspesi siswa terhadapkondisi ekonomi keluarganya dan pengaruhnya terhadap motivasimelanjutkan pendidikan keperguruan tinggi. Berdasarkan data yang telahdihimpun menujukkan bahwa para siswa Madrasah Aliyah Putra Al-Islahuddiny sebagian besar atau diatas rata-rata memiliki persepsi postifterhadap kemampuan keluarganya untuk membiayainya secara finansiamelanjutkan pendidikan keperguruan tinggi. Namun demikian cukupbanyak diantara mereka memiliki motivasi melanjutkan pendidikankeperguruan tinggi berada pada kategori kurang baik. Hal ini disebabkanberbagai factor antara lain tidak adanya kepastian untuk mendapatkanhasil secara ekonomilebih baik jika melanjutkan kuliah dibandingkantidak kuliah. Adanya motivasi belajar yang renda dan sebagian yang tidakmelanjutkan pendidikan keperguruan tinggi dikarenakan keinginannyauntuk lebih memperdalam pendidikan agama pada lembaga takhassusyang khsuus mengkaji pelajaran agama. Walaupun persepsi terhadapkeadaan ekonomi keluarga dikalangan siswa Madrasah Aliyah PutraAl-Islahuddiny berpengaruh signifikan terhadap motivasi melanjutkanpendidikan ke perguruan tinggi dan bersifat linear, namun pengaruhnyatidaklah besar
PENDIDIKAN DAN PENANAMAN BUDI PEKERTI
Authors: Latifah Nur
Published: June 2022

Orientasi pendidikan nasional yang cenderung melupakanpengembangan dimensi nilai dan moral telah merugikan peserta didiksecara individual maupun kolektif. Tendensi yang muncul adalah,peserta didik akan mengetahui banyak tentang sesuatu, namun iamenjadi kurang memiliki sistem nilai, sikap, minat maupun apresiasisecara positif terhadap apa yang diketahui. Anak akan mengalamiperkembangan intelektual tidak seimbang dengan kematangankepribadian sehingga melahirkan sosok spesialis yang kurang pedulidengan lingkungan sekitar (split personality) dan rentan mengalamidistorsi nilai.
EVALUASI PROGRAM PENYELENGGARAAN MTsN KEDIRI MODEL CIPP
Authors: Hizam Ibnu
Published: June 2022

Madrasah merupakan salah satu bentuk lembaga pendidikan islamyang memiliki peran sangat penting dalam membentuk karaktersumber daya manusia. Mengelola suatu lembaga pendidikan islam(madrasah) bukanlah hal yang mudah. Apalagi yang dimaksudmengelola tidak sekedar dalam pengertian mempertahankan yangsudah ada, tetapi melakukan pengembangan secara sistematik dansistemik, yang meliputi aspek ideologis (visi dan misi), kelembagaandan langkah operasionalnya serta mencerminkan pertumbuhan(growth), perubahan (change) dan pembaharuan (reform). Namundemikian lembaga pendidikan madrasah Tsanawiyah tida terlepas darisejumlah problem. Menurut data Direktorat Pendidikan Madrasahtahun 2007, terdapat 34,4% dari total 222.890 ruang kelas madrasahdi Indonesia dikategorikan rusak. Selain sarana dan prasarana, masihbanyak guru madrasah tsanawiyah yang belum memenuhi kualifikasiakedemik. Data Kementerian Agama disebutkan dari total jumlahpendidik (guru) untuk jenjang madrasah tsanawiyah sebanyak 112.793orang dengan 19,0% berstatus PNS, sisanya 81,0% berstatus nonPNS. Adapun yang berkualifikasi pendidikan pendidik minimal stratasatu (S1) yakni sebanyak 83.411 orang atau 74,0%, sisanya 26% nonS1, kondisi ini menunjukkan bahwa jumlah tersebut masih jauh dariharapan. Kondisi tersebut menuntut perbaikan yang dilandasi olehhasil evaluasi yang valid jika akan melakukan perbaikan yang tepat dilapangan agar dapat dilakukan perbaikan yang akurat.
PENGARUH BIMBINGAN KARIER TERHADAP KREATIVITAS SISWA KELAS VIII DI SMP NEGERI 2 KEDIRI KABUPATEN LOMBOK BARAT TAHUN PELAJARAN 2016/2017
Authors: Mardiana Mardiana , Jumailiyah Jumailiyah , Iman Nurul
Published: June 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh bimbingan karier terhadap kreativitas siswa kelas VIII di SMP Negeri 2 Kediri kab. Lombok barat tahun pelajaran 2016/2017. Permasalahan yang ada dalam penelitian ini adalah : Apakah Ada Pengaruh Bimbingan Karier Terhadap Kreativitas Siswa Kelas VIII Di SMP Negeri 2 Kediri Kabupaten Lombok Barat Tahun Pelajaran 2016/2017. Metode pengumpulan data yang digunakan dalam penelitian ini berupa angket sebagai metode pokok sedangkan observasi dan wawancara sebagai metode pelengkap sedangkan analisis data menggunakan uji Wilcoxon Berdasarkan dari hasil analisis data, yang diperoleh dalam penelitian ini adalah Dari tabel G ternyata bahwa untuk N = 10 diperoleh nilai T 0,05 = 3. Oleh karna itu diputuskan untuk menolak Ho, karena nilai T-hitung = 0 dan nilai T tabel = 3 Kesimpulannya adalah menolak hipotesis nihil (Ho), yang berbunyi: ada pengaruh bimbingan karier terhadap kreativitas siswa kelas VIII di SMP Negeri 2 Kediri Kabupaten Lombok Barat tahun pelajaran 2016/2017diterima. Dan dengan kenyataan ini menunjukkan bahwa nilai yang diperoleh adalah Signifikan. Maka dapat diambil kesimpulan bahwa ada Pengaruh Bimbingan Karier Terhadap Kreativitas Siswa Kelas VIII Di SMP Negeri 2 Kediri Tahun Pelajaran 2016/2017.
PENGARUH PENGGUNAAN MODEL PEMBELAJARAN AIR (AUDITORY, INTELLECTUALY, REPETITION) TERHADAP HASIL BELAJAR MATA PELAJARAN MATEMATIKA PADA SISWA KELAS VII SMP NEGERI 2 LEMBAR LOMBOK BARAT TAHUN PELAJARAN 2016/2017
Authors: Sakti Hadi Gunawan , Hikayati Sutria
Published: June 2022

Permasalahan utama dalam penelitian ini adalah proses pembelajaran masih menggunakan metode konvensional yaitu ceramah dan tanya jawab, masih rendahnya motivasi siswa dalam belajar khususnya pada mata pelajaran Matematika, Hal ini berdampak pada hasil belajar yang rendah, belum tercapainya ketuntasan belajar dan aktivitas siswa kurang. Rumusan masalah dalam penelitian ini adalah Apakah Ada Pengaruh Penggunaan Model Pembelajaran AIR (Auditory, Intellectually, Reppetition) Terhadap Hasil Belajar Mata Pelajaran Matematika Pada Siswa Kelas VII SMP Negeri 2 Lembar Lombok Barat Tahun Pelajaran 2016/2017?. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh penggunaan Model Pembelajaran AIR (Auditory, Intellectually, Repetition) Terhadap Hasil Belajar Mata Pelajaran Matematika Pada Siswa Kelas VII SMP Negeri 2 Lembar Lombok Barat Tahun Pelajaran 2016/2017. Untuk memperoleh data dalam penelitian ini digunakan metode tes sebagai metode utama dan metode observasi, dokumentasi, dan wawancara merupakan metode pendukung. Teknik analisisdata menggunakan rumus statistikt-test. Berdasarkan hasil analisis data diperoleh thitung8,718 sedangkan ttabelpada taraf signifikansi 5% dengan db = N-1=24-1= 23 diperoleh 2,069. Berdasarkan hasil tersebut maka thitung 8,718>ttabel 2,069. Hasil tersebut menunjukkan bahwa H0 ditolak dan Ha diterima, maka hasil analisis data dalam penelitian ini dinyatakan Signifikan. Dengan demikian dapat disimpulkan bahwa AdaPengaruh Penggunaan Model Pembelajaran AIR (Auditory, Intellectually, Repetition) Terhadap Hasil Belajar Mata Pelajaran Matematika Pada Siswa Kelas VII SMP Negeri 2 Lembar Lombok Barat Tahun Pelajaran 2016/2017.
THE EFECT OF SHORT ENGLISH MOVIES IN TEACHING LISTENING: AN EXPERIMENTAL STUDY AT EIGHT GRADE OF SMPN 10 MATARAM IN ACADEMIC YEAR 2015/2016
Authors: Zohraeni Liza , Iman Nurul
Published: June 2022

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh dari Film Pendek Bahasa Inggris dalam Pengajaran Listening. Penelitian ini menggunakan design kelompok eksperimen tunggal dan kelompok yang terpilih adalah kelas VIII-E yang terdiri dari 33 siswa. Teknik pengambilan sampel pada penelitian ini adalah random dampling atau sampel yang diambil secara acak. Dalam pengumpulan data, peneliti menggunakan pre-test, treatment, dan post test. Temuan ini menunjukkan bahwa nilai t-test lebih tinggi dari t-tabel. 12.98> 1,697 pada signifikan 0,05 dan 12,98> 2,750 dan pada tingkat signifikan 0,01 derajat kebebasan (df) 32. Hal ini berarti Hipotesis Nol (Ho) yang menyatakan bahwa “Tidak ada pengaruh yang signifikan dari penggunaan film pendek bahasa inggris dalam pengajaran mendengar “ditolak sedangkan Hipotesis Alternatif (Ha) yang menyatakan bahwa” Ada pengaruh yang signifikan dari penggunaan film pendek bahasa Inggris dalam pengajaran mendengar “diterima. Penelitian ini menunjukkan bahwa film pendek bahasa Inggris signifikan untuk diterapkan dalam pengajaran mendengar di kelas delapan SMPN 10 Mataram pada tahun akademik 2015/2016.
Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype
Authors: Rouhi Leila , Auguste Gaelle , Zhou Qiong , Lombardi Raffaella , Olcum Melis , Pourebrahim Kimia , Cheedsipudi Sirisha M. , Asghar Saman , Hong Kui , Robertson Matthew J. , Coarfa Cristian , Gurha Priyatansh , Marian Ali J.
Published: June 2022

Introduction: Mutations in the LMNA gene, encoding Lamin A/C (LMNA), are established causes of dilated cardiomyopathy (DCM). The phenotype is typically characterized by progressive cardiac conduction defects, arrhythmias, heart failure, and premature death. DCM is primarily considered a disease of cardiac myocytes. However, LMNA is also expressed in other cardiac cell types, including fibroblasts. Aim: The purpose of the study was to determine the contribution of the fibroblasts to DCM caused by LMNA deficiency. Methods and Results: The Lmna gene was deleted by crossing the platelet-derived growth factor receptor α-Cre recombinase (Pdgfra-Cre) and floxed Lmna (LmnaF/F) mice. The LMNA protein was nearly absent in ~80% of the cardiac fibroblasts and ~25% of cardiac myocytes in the Pdgfra-Cre:LmnaF/F mice. The Pdgfra-Cre:LmnaF/F mice showed an early phenotype characterized by cardiac conduction defects, arrhythmias, cardiac dysfunction, myocardial fibrosis, apoptosis, and premature death within the first six weeks of life. The Pdgfra-Cre:LmnaWild type/F(LmnaW/F) mice also showed a similar but slowly evolving phenotype that was expressed within one year of age. RNA sequencing of LMNA-deficient and wild-type cardiac fibroblasts identified differential expression of ~410 genes, which predicted activation of the TP53 and TNFA/NFκB and suppression of the cell cycle pathways. In agreement with these findings, levels of phospho-H2AFX, ATM, phospho-TP53, and CDKN1A, markers of the DNA damage response (DDR) pathway, were increased in the Pdgfra-Cre:LmnaF/F mouse hearts. Moreover, expression of senescence-associated beta-galactosidase was induced and levels of the senescence-associated secretory phenotype (SASP) proteins TGFβ1, CTGF (CCN2), and LGLAS3 were increased as well as the transcript levels of additional genes encoding SASP proteins in the Pdgfra-Cre:LmnaF/F mouse hearts. Finally, expression of pH2AFX, a bonafide marker of the double-stranded DNA breaks, was increased in cardiac fibroblasts isolated from the Pdgfra-Cre:LmnaF/F mouse hearts. Conclusion: Deletion of the Lmna gene in fibroblasts partially recapitulates the phenotype of the LMNA-associated DCM, likely through induction of double-stranded DNA breaks, activation of the DDR pathway, and induction of expression of the SASP proteins. The findings indicate that the phenotype in the LMNA-associated DCM is the aggregate consequence of the LMNA deficiency in multiple cardiac cells, including cardiac fibroblasts.
Profiling The Effect of Targeting Wild Isocitrate Dehydrogenase 1 (IDH1) on the Cellular Metabolome of Leukemic Cells
Authors: Shait Mohammed Mohammed Razeeth , Alzahrani Faisal , Hosawi Salman , Choudhry Hani , Khan Mohammad Imran
Published: June 2022

Leukemia represents as one of the most common primary malignancies of the hematologic system in both children’s and adults and remains a largely incurable or relapse disease. The elucidation of disease subtypes based on mutational profiling, has not improved clinical outcomes. IDH1/2 are key enzymes of TCA cycle that produces α-ketoglutarate (αKG), however their mutated version, are well reported in various cancer types including leukemia, produces D-2 hydroxyglutarate (D-2HG), an oncometabolite. Recently, some studies have shown that wild type IDH1 is highly expressed in non-small cell lung carcinoma (NSCLC), primary glioblastomas (GBM) and several hematological malignancies and corelates with disease progression. In this work, we have showed treatment of wild type IDH1 leukemia cells with specific IDH1 inhibitor switched leukemic cells towards gly-colysis from oxidative phosphorylation (OXPHOS) phenotype. We also noticed reduction in αKG in treated cells possible suggesting inhibition of IDH1 enzymatic activity. Further, we found that IDH1 inhibition reduces the metabolites related to one carbon metabolism, essential to maintain global methylation in leukemic cells. Finally, we observed that metabolic alteration in IDH1 inhibitor treated leukemic cells promotes reactive oxygen species (ROS) formation along with loss of mito-chondrial membrane potential, leading towards apoptosis in leukemic cells. Overall, we showed that wild type IDH1 targeting in leukemic cells promote metabolic alterations that can be exploited for combination therapies for better outcome.
From Text to E-text: Perceptions of Medical, Dental and Allied Students About E-learning
Authors: Fahim Ayesha , Rana Sadia , Atif Saira , Basha Sakeenabi , Haider Irsam , Alam Mohammad Khursheed , Nagarajappa Anil Kumar
Published: June 2022

In 2020, students of Pakistan had to adapt to the online environment for the very first time. This study aims to analyze the perceptions of medical, dental, and allied health students about online education in Pakistan. A descriptive, cross-sectional study was done to assess the level of acceptance of undergraduate students. A pre-validated questionnaire regarding demographics, past-experience of e-learning, advantages disadvantages of e-learning, and general perception of students towards e-learning was distributed. Descriptive statistics were computed for demographics, Mann-Witney-U test was used to compare the differences of perceptions between pre-clinical year and clinical years students. Kruskal-Wallis test was applied to compare the results of three specialties of students. Chi-square was used to compare overall category-wise positive and negative responses of students. 1200 students participated in the study. The major advantage identified by all students was the ‘comfortable environment’ in which they studied online. The major disadvantage selected by preclinical year students was ‘anxiety due to social isolation’ and that chosen by clinical year students was ‘lack of patient interaction’. Overall, 72% of students had a negative perception of e-learning. Student-teacher training, student counselling sessions, and innovative techniques need to be introduced to enhance student engagement and reduce pandemic stress.
Ligand and Structure-Based Virtual Screening in Combination, to Evaluate Small Organic Molecules as Inhibitors for the XIAP Anti-apoptotic Protein: The Xanthohumol Hypothesis
Authors: Mavra Angeliki , Petrou Christos , Vlasiou Manos C.
Published: June 2022

Herein, we are proposing two chalcone molecules, (E)-1-(4-methoxyphenyl)-3-(p-tolyl) prop-2-en-1-one and (E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) prop-2-en-1-one, based on the anticancer bioactive molecule Xanthohumol, which are suitable for further in vitro and in vivo studies. Their ability to create stable complexes with the antiapoptotic X-linked IAP (XIAP) protein makes them promising anticancer agents. The calculations were based on ligand-based and structure-based virtual screening combined for the pharmacophore built. Additionally, the structures passed Lipinski's rule for drug use, and their reactivity was confirmed using density functional theory studies. The candidates were chosen between 10639400 compounds, and the docking protocols were evaluated using molecular dynamics simulations.
Mirage or Miracle—Intraovarian Autologous Platelet Cytokines for Infertility and Menopause
Authors: Sills E. Scott
Published: June 2022

On a bleak therapeutic landscape unchanged since the 1980’s, IVF with egg donation still stand as the lone medical answer to diminished reserve and premature ovarian insufficiency. Intraovarian platelet-rich plasma (PRP) crossed the horizon in 2016 as hopeful answer to these intertwined problems. The once remote mirage of platelet cytokine effects on gene regulation or telomere stabilization is now in sharper focus, and current work is clarifying how PRP corrects oxidative stress, rectifies tissue hypoxia, downregulates apoptosis, and enhances cellular metabolism. Not yet ready for routine use, this investigational treatment does offer one point of general agreement: How intraovarian PRP results should be classified—Patients are either responders or non-responders. From this, it is intriguing that no published PRP protocol has reported a supranormal ovarian rebound or hyperstimulation effect. This could be explained by baseline age-related ovarian conditions prevalent among poor responders, but since dysregulated or malignant transformations are also absent in other tissue contexts following autologous PRP treatment, the contribution of some platelet product which intrinsically delimits regenerative action cannot be discounted. Here we summarize results with recent experimental and clinical platelet research, framing those most likely to help advance reproductive endocrinology practice.
A Large-Scale Dataset of Twitter Chatter about Online Learning during the Current COVID-19 Omicron Wave
Authors: Thakur Nirmalya
Published: June 2022

The COVID-19 Omicron variant, reported to be the most immune evasive variant of COVID-19, is resulting in a surge of COVID-19 cases globally. This has caused schools, colleges, and universities in different parts of the world to transition to online learning. As a result, social media platforms such as Twitter are seeing an increase in conversations related to online learning. Mining such conversations, such as Tweets, to develop a dataset can serve as a data resource for interdisciplinary research related to the analysis of interest, views, opinions, perspectives, attitudes, and feedback towards online learning during the current surge of COVID-19 cases caused by the Omicron variant. Therefore this work presents a large-scale public Twitter dataset of conversations about online learning since the first detected case of the COVID-19 Omicron variant in November 2021. The dataset is compliant with the privacy policy, developer agreement, and guidelines for content redistribution of Twitter, as well as with the FAIR principles (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data management. The paper also briefly outlines some potential applications in the fields of Big Data, Data Mining, Natural Language Processing, and their related disciplines, with a specific focus on online learning during this Omicron wave that may be studied, explored, and investigated by using this dataset.
Erroneous AI-classification Systems Produce Creative Design Ideas, Predicting Level of Innovation Value
Authors: Hoorn Johan F.
Published: June 2022

In the mid-layers of Deep Learning systems, clustered features tend to fit multiple classifications, which are filtered out during the final stages of object recognition. However, many misclassifications remain, regarded as errors of the system. This paper claims that tagging an entity incorrectly for reasons of similarity is evidence of spontaneous machine creativeness. According to the ratings of 40 design educators and researchers, AI-generated false-class inclusions produced creative design ideas, predicting the level of innovation value. These designers were not just anybody but came from a design school in Asia with a top position on the world ranking-lists. They entered an experiment in which 20 classification mistakes were framed as early-design ideas that were either human-made or intentionally suggested by creative AI. Many examples passed the Feigenbaum variant of the Turing test with a conceptual preference to creations supposedly done by human hand.
Early Prediction of Ventilator-Associated Pneumonia in ICU Patients Using An Interpretable Machine Learning Algorithm
Authors: Faucher Maxime , Casie Chetty Satish , Shokouhi Sepideh , Barnes Gina , Rahmani Keyvan , Calvert Jacob , Mao Qingqing
Published: June 2022

(1) Background: Ventilator-associated pneumonia (VAP) causes high mortality among patients with respiratory disease and imposes major burdens on healthcare infrastructure. Models that use electronic health record data to predict the onset of VAP may spur earlier treatment and improve patient outcomes. We developed and studied the performance of interpretable machine learning (ML) models that predict the onset of VAP from electronic health records (EHRs); (2) Methods: We trained Logistic Regression (LR), full feature Explainable Boosting Machine (fEBM), and eXtreme Gradient Boosting (XGBoost) ML models on data from the MIMIC- III (v1.3) database. Model performance was measured by area under the receiver operating characteristic curves (AUCs). We trained a minimal-feature EBM model (mEBM) with features derived from white blood cell (WBC) counts, duration of ventilation, and Glasgow Coma Scale (GCS). Finally, model robustness was evaluated on randomly sparsified EHR datasets; (3) Results: The fEBM model outperformed the XGBoost and LR models at 24 hours post-intubation. The mEBM model maintained an AUC of 0.893. The fEBM model performance remained robust on sparsified datasets; (4) Conclusions: Our novel interpretable ML algorithm reliably predicts the onset of VAP in intubated patients. Integration of this EBM-based model into clinical practice may enable clinicians to better anticipate and prevent VAP.
Creating a Re-Tech Theme Park through the Neuromarketing and Cartoon Characters
Authors: Bu Naipeng (Tom) , Parra-López Eduardo , Barrientos-Baez Almudena , Li Tairan , Pérez-Sánchez María de los Ángeles
Published: June 2022

Renewable energy technologies (RET) are critical to the sustainable development of modern societies. Hong Kong has set up a RET theme park so as to fulfill the needs of and impart knowledge on RET through entertainment and educational activities. Such understanding aids in formulating appropriate future park designs and neuromarketing strategies to maximize the attractiveness of the park. Therefore, this study attempts to investigate potential visitors’ preferences with regard to cartoon characters in the RET theme park, especially for student groups to meet the “edutainment” theme of the park. A total of 400 people have participated in this study. Findings indicate that Snoopy, Mickey Mouse, and Donald Duck show a high degree of likeness of presence in the RET theme park.
Radial Power Spectral Characterizations of Near Surface Rainfall Rates Using Time-Height Vertically Pointing Doppler Radar Measurements
Authors: Jameson A. R. , Larsen Michael
Published: June 2022

It has been shown that the Micro-Rain Radar (MRR) can be used to derive rainfall rates every 10 m over a depth of 1.28 km using the mean vertical air velocity corrected Doppler raindrop fall speed spectra. Furthermore, it has been shown that by assuming a reasonable advection velocity for the rain, these data can be analyzed to produce spatial radial power spectra often readily fit using a power function. Previous work has shown, however, that each spectrum applies only to each particular set of data and usually lacks the statistical qualifications necessary to be considered generally applicable. However, this limitation does not preclude the potential existence of other generalizations that can be used to explore the rainfall formation processes. The intent of this study, then, is to perform an initial look for such possible behaviors using time-height profiles of the rainfall rate. It is found that once the rainfall rate, R, exceeds about 20 mm h-1, there is, apparently, an associated flattening of the spectra with increasing R so that the smaller scales play an ever increasingly important role in such rain near the ground perhaps reflecting the increasing importance of such scales in the formation of pockets of more intense convective rain. The true generality of this finding needs additional scrutiny using more data particularly from two spatially separated MRR as is currently under preparation.
An integrated approach of GIS-AHP-MCE methods for the selection of suitable sites for the shrimp farming and mangrove development- A case study of the coastal area of Vietnam
Authors: Nguyen Hoai Thi , Hoang Thuy Thi , Van Luong Vu , Prakash Indra , Tran Tuyen Thi
Published: June 2022

This study was conducted to identify suitable sites for shrimp farming combined with the mangrove development (SFM) in the coastal area of central Vietnam. An integrated approach using GIS with weighted Multi-Criteria Evaluation (MCE) by Analytic Hierarchy Process (AHP) was adopted for the selection of sites. In this study, fifteen sub-criteria belonging to three main criteria (geographical conditions, water quality and infrastructure availability) were selected as evaluation parameters in the GIS model. The study indicated that the geographical factors are the most important for the SFM development with 0.44 weight. However, the availability of such areas is limited. Results of the integrated study indicated that SFM area for development is highly suitable: 1127.82 ha (15.57%), moderately suitable: 2056.87 ha (28.4%), marginally suitable: 2835.52 ha (39.16 %) and not suitable: 3204.36 ha (17.0 %) in the Hau basin, Vietnam. In this study, we have also used GIS-AHP-MCE methods for developing organic shrimp farming and mangrove rehabilitation.
Working Status, Adequacy of Support, and Nursing Professional Pride among Frontline Nurses at a Designated COVID-19 Hospital
Authors: Jung Da Hye , Jang Gun Ja , Lee Hye Sook , Lee Hyunjin , Ko Sangjin
Published: June 2022

Objectives: The purpose of this study was to investigate experiences such as working status, adequacy of support system from the nation and local government, and nursing professional pride of nurses working at a Coronavirus disease-2019 (COVID-19) designated hospital during the early COVID-19 pandemic in Daegu Metropolitan City, South Korea.Methods: This study was a cross-sectional study. Participants were 157 nurses who cared for 851 patients with coronavirus infectious disease during the initial pandemic from February 18 to May 18, 2020. Work-related characteristics, national/local government/institutional support provided for risky nursing care, and nursing professional pride (Korean-Nursing Professional Pride) were surveyed from January 15 to February 15, 2020. Data were analyzed by descriptive statistics.Results: Nurses worked 21 to 22 days with 7 to 8 days of overtime working a month and 2.06 hours of overtime working a day due to a shortage of nursing staff. Of them, 97.5% of nurses demonstrated concern about the transmission of COVID-19. Despite the working conditions, many participants perceived national and local government support systems for challenging works as insufficient. However, the nursing professional pride was 3.44, and more than 90% of nurses perceived increased professional awareness of nurses.Conclusions: This study suggested that frontline nurses were overworked due to the explosive increase of patients and inadequately compensated, and policies should be established to improve these issues.
Joined Bi-Model RNN with Spatial Attention and GAN based IoT bot net Attacks Detection
Authors: S Senthil , Muthukumaran N
Published: June 2022

Currently, in many purposes machine and deep learning methods were utilized to identify bot net threats in IoT networks. On the other hand, highly imbalanced network traffic information in the training set frequently humiliates the classification. A novel method is proposed called Joined Bi-Model RNN with Spatial Attention (JBiRSA). In this work, feature generation and classification is the two major processes. For feature generation process, Generative Adversarial Network (GAN) is applied. GAN consist of two neural networks, namely Generator and Discriminator. In GAN, loss is also calculated to enhance accuracy In this model GAN with Traffic Encoder loass is proposed along with an effective generator especially suited for network traffic. Two data sets are used, namely N-BaIoT and IoT-23. N-BaIoT data set is formed by adding bot net attacks such as Bashlite and Mirai. IoT-23 data set is formed with 20 malware confines from various IoT devices and 3 precincts for benign anomalies. JBiRSA with GAN has proven to be efficient and has the potential to differentiate between benign and malicious traffic data in IoT attacks. JBiRSA with GAN provides an overall accuracy of 98.75%.
Effects of different planting distances and fertilizer use on remediation of cadmium contaminated farmland by intercropping of Pumpkin and amaranth hypochondriacus L.
Authors: Chen Weizhen , Yang Yanan , Zhou Mengya , Li Yinshi , Gong Maojian , Kang Zhiming , Li Huashou
Published: June 2022

Soil cadmium pollution has become one of the most serious pollution problems of farmland soil in China. Selecting suitable plants for intercropping can restore Cd contaminated soil while ensuring safe crop production. Through field and cement pool experiments, the crop growth and Cd uptake of pumpkin-amaranth intercropping system planted with different densities and different fertilizer treatments were studied. Field experiment results showed that the Cd content of pumpkin in different systems were lower than national food safety standard (0.05 mg kg− 1). In the IN-1 (4 pumpkin plants intercropped with 200 amaranth plants) and IN-2 (4 pumpkin plants intercropped with 400 amaranth plants)systems, the single plant Cd concentration of amaranth increased by 32.43% and 25.25%, respectively, compared with that monocropping system (P < 0.05). The IN-2 system had the highest equivalent ratio of heavy metal removal (3.08), indicating that this planting method had a great advantage in heavy metal removal. All the pumpkins treated with four kinds of fertilizers in cement pool experiment could achieve safe production, and chicken manure had the best promotion effect on the growth and yield of the two plants. The yield of pumpkin (per plant) treated with chicken manure is significantly higher than other treatments (P < 0.05). Our results indicated that pumpkin-amaranth intercropping system is a good model for crop safety and remediation of Cd contaminated soil. At the same time, using 4 pumpkin and 400 amaranth plants intercropping and applying chicken manure fertilizer was a good way to strengthen the intercropping system.
Factors controlling net soil nitrogen mineralization rates in Japanese forest ecosystems
Authors: SASAKI Mayu , Mukai Mana , Aiba Shin-ichiro , Homma Kosuke , Takyu Masaaki , Kurokawa Hiroko , Kitayama Kanehiro
Published: June 2022

Background and aimsNet soil nitrogen (N) mineralization rate represents bioavailable N supply rate. Exploring its controlling factors improves the knowledge of N cycling. Previous studies in Japanese forests revealed that high soil organic matter (SOM) content of volcanic soils enhanced net N mineralization rates. However, the effects of cations and phosphorus (P) added by volcanic ash are not fully understood. We investigated the influences of volcanic ash addition on net N mineralization via P and cation availabilities.MethodsNet soil N mineralization rates of surface soils (0-5 cm) collected from 20 sites across Japan were determined under the common laboratory condition (20 ℃, 10 days). The concentration of amorphous minerals (Alo+1/2Feo; a surrogate of volcanic ash) was included as an independent variable as a surrogate of volcanic ash in a structural equation modelling (SEM). In addition, conifer abundances and mean annual temperatures of the origins of soils were also included in the model.ResultsNet soil N mineralization rates differed among sites, suggesting that soil substrates were inherently determined by site conditions. Alo+1/2Feo positively affected net soil N mineralization rate via the concentrations of total P and labile P. Conifer abundance weakly affected net soil N mineralization rate. Temperature was not selected in the model.ConclusionsNet soil N mineralization rates in Japanese forest ecosystems are most strongly determined by the amount of added volcanic ash via P availability. These findings improve our understanding for the diversification of forest ecosystems under volcanic activities.
Enhanced Adsorption of Cu(II) and Ni(II) ions from animal feeds processing industry wastewater by Reusable Mesoporous Palladium-Silver-Carbon nanotubes Composite
Authors: Tijani Jimoh , Usman Nurudeen , Abdulkareem Ambali , Ndaba Busiswa , Mbianda Xavier
Published: June 2022

This study focused on the development of a novel Palladium (Pd)-Silver (Ag)-Carbon nanotubes adsorbent for the removal of Cu(II) and Ni(II) ions in industrial animal feed processing wastewater. Carbon nanotubes (CNTs) were produced via a catalytic chemical vapour deposition (CCVD) method and then purified by acid mixture of H2SO4 and HNO3. Pd-Ag-CNTs nanocomposites were produced through a combination of ultrasonic-assisted wet impregnation methods. Different analytical tools such as HRSEM, HRTEM, EDS, SAED, XRD and BET were used to characterize the prepared nanoadsorbent. The HRSEM analysis revealed homogeneous dispersion of Pd and Ag nanoparticles on the CNTs matrix. XRD pattern confirmed formation of graphitic face-centered cubic structure with or without metal matrix nanoparticles with an average crystallite sizes of 26.10 nm (Pd-Ag-CNTs) > 13.00 nm (Pure-CNTs). BET analysis showed that simultaneous addition of Pd and Ag nanoparticles onto CNTs contributed to enhanced surface area of (392.5 m2/g) compared to Pure-CNTs (227.63 m2/g). The effect of contact time, adsorbent dosage, and temperature on the nanoadsorbent efficacy with respect to Cu(II) and Ni(II) ions removal were investigated via batch adsorption mode. The optimum condition for the maximum removal of Ni(II) ions (99.84%) and Cu(II) ions (77.86%) by Pd-Ag-CNTs were contact time (90 min), adsorbent dosage (60 mg)and reaction temperature (60°C). The adsorption isotherm data best fitted Florry-Huggins model based on the χ2, SSE and regression co-efficient values of 0.9947 (Cu) and 0.7098 (Ni), while the kinetic data suited pseudo-second order. The thermodynamic study was found to be non-spontaneous and endothermic in nature. This study demonstrated for the first time that Pd-Ag-CNTs exhibited exceptional adsorptive and recyclability properties for the removal of Cu(II) and Ni(II) ions from industrial animal feed processing wastewater even after five cycles.
Diagnosis and management of ADHD: A pediatric perspective on practice and challenges in Switzerland
Authors: Zysset Annina , Robin Dominik , Albermann Kurt , Dratva Julia , Hotz Sandra , Wieber Frank , von Rhein Michael
Published: June 2022

Background: Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in childhood. In Switzerland, the complex diagnosis and treatment are being carried out by adolescent-/child psychiatrists, and pediatricians. Guidelines recommend a multimodal therapy for patients with ADHD. However, it has been questioned whether health professionals follow this approach or favor drug therapy. This study aims to provide insights into the practice of pediatricians in Switzerland regarding diagnosis and treatment of ADHD and their perceptions of these processes. Method: An online survey (self-report) about current practices of diagnosis and management as well as challenges regarding ADHD was distributed to office-based pediatricians in Switzerland. 151 pediatricians participated. Results show that therapy options were almost always discussed with parents and older children. Exchange with parents (81%) and level of child’s suffering (97%) were central when selecting therapy options. Results: Therapies about which pediatricians informed most often were: pharmacological therapy, psychotherapy, and multimodal therapy. Challenges voiced were the subjectivity of diagnostic criteria and dependence on third parties, low availability of psychotherapy, and a rather negative public attitude towards ADHD. Needs that were expressed were further education for all professionals, support for coordination with specialists and schools as well as improvement of information on ADHD. Conclusions: Pediatricians do consider a multimodal approach when treating ADHD and take the families` and children`s opinions into account. Improvements of the availability of child and youth psychotherapy, the strengthening of the interprofessional cooperation with therapists and schools, and efforts to increase public knowledge about ADHD are proposed.
Endoscopic lavage and application of rTPA in multiloculated hydrocephalus: a mono-center experience
Authors: Wilhelmy Florian , Fehrenbach Michael Karl , Krause Matthias , Siekmeyer Manuela , Paets Anne Bettina , Merkenschlager Andreas , Meixensberger Jürgen , Kasper Johannes
Published: June 2022

Objective: This study focuses on treatment of multiloculated hydrocephalus (HCP) following ventricular infection. Post-infectious hydrocephalus in the premature infant is a complicated disease and dire to treat as it tends to re-occur despite multiple surgical procedures. Here, we report our experience in rtPA (recombinant tissue-type plasminogen activator) application and neuroendoscopic lavage to treat post-infectious HCP. Methods: This retrospective series comprises on six premature infants with a history of intraventricular infection. In the course of treatment, neuroendoscopy, external ventricular drainage, antibiotic treatment and lavage have been performed. rtPA has been applied intraventricularily in three patients in individual regimen (s. below) to dissolve membranes, septs and cysts to facilitate cerebro-spinal fluid (CSF) circulation. Besides clinical outcome CSF and laboratory parameters as well as MR/sonographic morphology are evaluated.Results: Here, rtPA application did not cause hemorrhagic complications. Improvement of CSF parameters, such as lactate, glucose and protein levels, was limited while MRI and ultrasound imaging demonstrated successful dissolving of intraventricular septs and cysts. The overall neurological outcome was poor. Thus, a beneficial impact of rtPA installation on the neurological outcome remains uncertain.Conclusion: In our experience, rtPA was safely instilled to dissolve intraventricular septation and to reduce protein precipitation in ventriculitis in neonates and preterm infants. Shunt interventions were presumably reduced in our cohort, probably due to prevention of multiloculated hydrocephalus. A beneficial impact on neurological status was absent as clinical outcome was generally poor. Outcome scores did not apply, or showed no difference, respectively.
MiR-19a-3p mitigates hypoxia/reoxygenation-induced apoptosis in H9C2 cardiomyocytes by targeting SOCS3
Authors: Xia Zirong , Yu Lingling , Bao huihui , Li Juxiang , Cheng Xiaoshu
Published: June 2022

The available treatment strategies for myocardial ischemia-reperfusion (I/R) injuries have not been so much effective. MicroRNAs (miRNAs) from the miR-19 family, which includes miR-19a and miR-19b, modulate both proliferation and apoptosis in the myocardium. The correlation between I/R injury and miR-19a-3p is unknown. Here, the role of miR-19a-3p in injuries induced by I/R was investigated in H9C2 cardiomyocytes. The MiR-19a-3p Levels were determined to be reduced after hypoxia/reoxygenation (H/R) and miR-19a-3p overexpression reduced apoptosis resulting from H/R, improving the activity of the cells. The opposite effect was observed when miR-19a-3p was inhibited. Potential miR-19a-3p targets were investigated using bioinformatics, identifying Protein Suppressor of cytokine signaling-3 (SOCS3), which was verified by luciferase reporter assays. SOCS3 levels were lower by overexpression of miR-19a-3p. SOCS3 silencing prevented apoptosis induced by miR-19a-3p inhibition, whereas overexpression of SOCS3 blocked a miR-19a-3p mimic's effects on apoptosis. According to these findings, miR-19a-3p reduces apoptosis and injury induced by H/R in cardiomyocytes through targeting SOCS3, and that targeting miR-19a-3p/SOCS3 signalling may present a new strategy in the therapy of myocardial I/R injury.