bluuebunny/crossref_metadata_2025 huggingface dataset:
Stereotactic Re-Irradiation for Local Recurrence after Radical Prostatectomy and Radiation Therapy: A Retrospective Multicenter Study
Authors: Perennec Tanguy , Vaugier Loig , Toledano Alain , Scher Nathaniel , Thomin Astrid , Pointreau Yoann , Janoray Guillaume , De Crevoisier Renaud , Supiot Stéphane
Published: August 2021

Prostate cancer recurrence in patients previously treated with radical prostatectomy and radiation therapy is challenging. Re-irradiation could be an option, but data regarding efficacy and safety are lacking. We retrospectively evaluated salvage re-irradiation for local recurrence after prostatectomy and external beam radiation therapy. We collected data from 48 patients who underwent salvage reirradiation with stereotactic radiation therapy for local prostate cancer recurrence in the prostatic bed at four French centers. Fifteen patients (31%) were on androgen deprivation therapy during stereotactic radiotherapy. Biochemical response and relapse-free survival were analyzed, and post-treatment toxicities were assessed according to the Common Terminology of Adverse Events criteria. Five patients had grade 3 late bladder toxicity (cystitis), three had grade 3 late incontinence, and one had grade 3 late chronic pain. At three months, 83% of patients had a positive biochemical response. The median follow-up was 22 months. At the end of the follow-up, 21 patients (43%) had a biochemical relapse. The median time to biologic relapse was 27 months. The biochemical relapse rates at 1 and 2 years were 80% and 52%, respectively. In conclusion, salvage re-irradiation for recurrent prostate cancer in the prostate bed may generate significant toxicity rates, and a prospective study with appropriate patient selection is needed to evaluate its effectiveness.
The Day after Mass COVID-19 Vaccination: Higher Hypermetabolic Lymphadenopathy Detection on PET/CT and Impact on Oncologic Patients Management
Authors: Ferrari Cristina , Nappi Anna Giulia , Santo Giulia , Mammucci Paolo , Rubini Dino , Tucci Marco , Pisani Antonio Rosario
Published: August 2021

The widespread COVID-19 vaccination led to unexpected PET findings. Notably, axillary and interpectoral lymphadenopathies ipsilateral to the vaccine inoculation were observed. We aimed to assess the hypermetabolic lymphadenopathy (HLN) detection rate on PET/CT. Secondly, we investigated factors that might help in HLN differential diagnosis. A retrospective analysis on 1196 consecutive patients referred for a PET/CT was performed. All patients were asked about the date, type and site of vaccine injections. HLNs were recorded and categorized according to risk classes and SUVmax grades. A statistical analysis was performed to assess the correlation between HLN detection and different clinical/vaccine data. HLN detection rate was 15% and 27% in the No Vac- and vac-groups (p < 0.001), respectively. In the Vac-group, age (p < 0.001) and time interval from vaccine-to-PET (p = 0.010) were inversely correlated with HLN detection. Furthermore, SUVmax significantly changed during time intervals, with lower values beyond 20 days (p < 0.001). In the era of mass COVID-19 vaccination, a higher axillary and interpectoral lymphadenopathies detection ipsilateral to vaccine injection was observed. These PET findings can be wrongly interpreted, complicating cancer patients’ management. To minimize these pitfalls, a detailed vaccination anamnesis must be recorded and should take into account the appropriate PET schedule.
Host–Microbiota Interactions in Liver Inflammation and Cancer
Authors: Giraud Julie , Saleh Maya
Published: August 2021

Hepatocellular carcinoma (HCC) is a classical inflammation-promoted cancer that occurs in a setting of liver diseases, including nonalcoholic fatty liver disease (NAFLD) or alcoholic liver disease (ALD). These pathologies share key characteristics, notably intestinal dysbiosis, increased intestinal permeability and an imbalance in bile acids, choline, fatty acids and ethanol metabolites. Translocation of microbial- and danger-associated molecular patterns (MAMPs and DAMPs) from the gut to the liver elicits profound chronic inflammation, leading to severe hepatic injury and eventually HCC progression. In this review, we first describe how the gut and the liver communicate and discuss mechanisms by which the intestinal microbiota elicit hepatic inflammation and HCC. We focus on the role of microbial products, e.g., MAMPs, host inflammatory effectors and host–microbiome-derived metabolites in tumor-promoting mechanisms, including cell death and senescence. Last, we explore the potential of harnessing the microbiota to treat liver diseases and HCC.
Implementation of Multigene Germline and Parallel Somatic Genetic Testing in Epithelial Ovarian Cancer: SIGNPOST Study
Authors: Chandrasekaran Dhivya , Sobocan Monika , Blyuss Oleg , Miller Rowan E. , Evans Olivia , Crusz Shanthini M. , Mills-Baldock Tina , Sun Li , Hammond Rory F. L. , Gaba Faiza , Jenkins Lucy A. , Ahmed Munaza , Kumar Ajith , Jeyarajah Arjun , Lawrence Alexandra C. , Brockbank Elly , Phadnis Saurabh , Quigley Mary , El Khouly Fatima , Wuntakal Rekha , Faruqi Asma , Trevisan Giorgia , Casey Laura , Burghel George J. , Schlecht Helene , Bulman Michael , Smith Philip , Bowers Naomi L. , Legood Rosa , Lockley Michelle , Wallace Andrew , Singh Naveena , Evans D. Gareth , Manchanda Ranjit
Published: August 2021

We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway of unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1 and parallel somatic BRCA1/BRCA2 testing in all women with epithelial-OC and highlight the discordance between germline and somatic testing strategies across two cancer centres. Patients were counselled and consented by a cancer MDT member. The uptake of parallel multi-gene germline and somatic testing was 97.7%. Counselling by clinical-nurse-specialist more frequently needed >1 consultation (53.6% (30/56)) compared to a medical (15.0% (21/137)) or surgical oncologist (15.3% (17/110)) (p < 0.001). The median age was 54 (IQR = 51–62) years in germline pathogenic-variant (PV) versus 61 (IQR = 51–71) in BRCA wild-type (p = 0.001). There was no significant difference in distribution of PVs by ethnicity, stage, surgery timing or resection status. A total of 15.5% germline and 7.8% somatic BRCA1/BRCA2 PVs were identified. A total of 2.3% patients had RAD51C/RAD51D/BRIP1 PVs. A total of 11% germline PVs were large-genomic-rearrangements and missed by somatic testing. A total of 20% germline PVs are missed by somatic first BRCA-testing approach and 55.6% germline PVs missed by family history ascertainment. The somatic testing failure rate is higher (23%) for patients undergoing diagnostic biopsies. Our findings favour a prospective parallel somatic and germline panel testing approach as a clinically efficient strategy to maximise variant identification. UK Genomics test-directory criteria should be expanded to include a panel of OC genes.
Orchestrating the Participation of Women Organisations in the UNFCCC Led Climate Finance Decision Making
Authors: Frenova Svetlana
Published: August 2021

The study applies orchestration as a conceptual framework to provide early evidence on the engagement of women organisations in UNFCCC-led climate finance governance and reflect on the quality of their mobilisation. Women organisations are one of the non-state stakeholders, whose role is acknowledged in the UNFCCC Decision 3/CP.25 for improving gender-responsiveness of climate finance. Within the UNFCCC, orchestration is used as a governance approach to enhance the mobilisation of non-state actors for facilitating the implementation of policy goals. The study utilises mixed methods including document review and interviews with key informants. The findings of the study indicate that the quality of orchestration has been low, i.e., the engagement of women organisations in the UNFCCC-led climate finance decision making has, so far, been limited. This is due to the lack of policy convergence on the purposes of orchestration, as well as the newness, and complexity of the issues at the intersection of climate finance and gender. While the concept of orchestration is intended to enhance decision making practices, the study suggests that in the case of the engagement of women organisations in the UNFCCC-led climate finance governance, orchestration is used only for symbolic purposes. To make the engagement of women organisations more meaningful, there is a need to diversify the existing orchestration practices and improve consistency in policy framing.
MRI and Targeted Biopsy Essential Tools for an Accurate Diagnosis and Treatment Decision Making in Prostate Cancer
Authors: Samtani Suraj , Burotto Mauricio , Roman Juan Carlos , Cortes-Herrera Daniela , Walton-Diaz Annerleim
Published: August 2021

Prostate cancer (PCa) is one of the most frequent causes of cancer death worldwide. Historically, diagnosis was based on physical examination, transrectal (TRUS) images, and TRUS biopsy resulting in overdiagnosis and overtreatment. Recently magnetic resonance imaging (MRI) has been identified as an evolving tool in terms of diagnosis, staging, treatment decision, and follow-up. In this review we provide the key studies and concepts of MRI as a promising tool in the diagnosis and management of prostate cancer in the general population and in challenging scenarios, such as anteriorly located lesions, enlarged prostates determining extracapsular extension and seminal vesicle invasion, and prior negative biopsy and the future role of MRI in association with artificial intelligence (AI).
Characteristics of Soil Respiration and Its Components of a Mixed Dipterocarp Forest in China
Authors: Zhao Jun-Fu , Liao Zhi-Yong , Yang Lian-Yan , Shi Jian-Kang , Tan Zheng-Hong
Published: August 2021

Background: Although numerous studies have been carried out in recent decades, soil respiration remains one of the less understood elements in global carbon budget research. Tropical forests store a considerable amount of carbon, and a well-established knowledge of the patterns, components, and controls of soil respiration in these forests will be crucial in global change research. Methods: Soil respiration was separated into two components using the trenching method. Each component was measured at multiple temporal scales and in different microhabitats. A commercial soil efflux system (Li8100/8150) was used to accomplish soil respiration monitoring. Four commonly used models were compared that described the temperature dependence of soil heterotrophic respiration using nonlinear statistics. Results and Conclusions: Trenching has a limited effect on soil temperature but considerably affects soil water content due to the exclusion of water loss via tree transpiration. Soil respiration decreased gradually from 8 to 4 μmol·m−2·s−1 6 days after trenching. Soil autotrophic (Ra) and heterotrophic respiration (Rh) have contrasting diel patterns and different responses to temperature. Rh was negatively correlated with temperature but positively correlated with relative humidity. Both Ra and Rh varied dramatically among microhabitats. The Q10 value of Rh derived using the Q10 model was 2.54. The Kirschbaum–O’Connell model, which implied a strong decrease of Q10 with temperature, worked best in describing temperature dependence of Rh. Heterotrophic respiration accounted for nearly half of the total soil efflux. We found an unexpected diurnal pattern in soil heterotrophic respiration which might be related to diurnal moisture dynamics. Temperature, but not soil moisture, was the major controller of seasonal variation of soil respiration in both autotrophic and heterotrophic components. From a statistical perspective, the best model to describe the temperature sensitivity of soil respiration was the Kirschbaum–O’Connell model. Soil respiration varied strongly among the microhabitats and played a crucial role in stand-level ecosystem carbon balance assessment.
GWAS and Post-GWAS High-Resolution Mapping Analyses Identify Strong Novel Candidate Genes Influencing the Fatty Acid Composition of the Longissimus dorsi Muscle in Pigs
Authors: Lee Jae-Bong , Kang Yong-Jun , Kim Sang-Geum , Woo Jae-Hoon , Shin Moon-Cheol , Park Nam-Geon , Yang Byoung-Chul , Han Sang-Hyun , Han Kang-Min , Lim Hyun-Tae , Ryu Youn-Chul , Park Hee-Bok , Cho In-Cheol
Published: August 2021

Fatty acid (FA) composition is one of the most important parameters for the assessment of meat quality in pigs. The FA composition in pork can also affect human health. Our aim was to identify quantitative trait loci (QTLs) and positional candidate genes affecting the FA profile of the longissimus dorsi muscle in a large F2 intercross between Landrace and Korean native pigs comprising 1105 F2 progeny by genome-wide association studies (GWAS) and post-GWAS high-resolution mapping analyses. We performed GWAS using the PorcineSNP60K BeadChip and a linear mixed model. Four genome-wide significant QTL regions in SSC8, SSC12, SSC14, and SSC16 were detected (p < 2.53 × 10−7). Several co-localizations of QTLs in SSC12 for oleic acid, linoleic acid, arachidonic acid, monounsaturated FAs, polyunsaturated FAs, and the polyunsaturated/saturated FA ratio were observed. To refine the QTL region in SSC12, a linkage and linkage disequilibrium analysis was applied and could narrow down the critical region to a 0.749 Mb region. Of the genes in this region, GAS7, MYH2, and MYH3 were identified as strong novel candidate genes based on further conditional association analyses. These findings provide a novel insight into the genetic basis of FA composition in pork and could contribute to the improvement of pork quality.
Novel Microsatellite Markers Used for Determining Genetic Diversity and Tracing of Wild and Farmed Populations of the Amazonian Giant Fish Arapaima gigas
Authors: Fazzi-Gomes Paola Fabiana , Aguiar Jonas da Paz , Marques Diego , Fonseca Cabral Gleyce , Moreira Fabiano Cordeiro , Rodrigues Marilia Danyelle Nunes , Silva Caio Santos , Hamoy Igor , Santos Sidney
Published: August 2021

The Amazonian symbol fish Arapaima gigas is the only living representative of the Arapamidae family. Environmental pressures and illegal fishing threaten the species’ survival. To protect wild populations, a national regulation must be developed for the management of A. gigas throughout the Amazon basin. Moreover, the reproductive genetic management and recruitment of additional founders by aquaculture farms are needed to mitigate the damage caused by domestication. To contribute to the sustainable development, we investigated the genetic diversity of wild and cultivated populations of A. gigas and developed a panel composed by 12 microsatellite markers for individual and population genetic tracing. We analyzed 368 samples from three wild and four farmed populations. The results revealed low rates of genetic diversity in all populations, loss of genetic diversity and high inbreeding rates in farmed populations, and genetic structuring among wild and farmed populations. Genetic tracing using the 12 microsatellite markers was effective, and presented a better performance in identifying samples at the population level. The 12-microsatellite panel is appliable to the legal aspects of the trade of the A. gigas, such as origin discrimination, reproductive genetic management by DNA profiling, and evaluation and monitoring of genetic diversity.
Chromosomal Aberrations in Cattle
Authors: Holečková Beáta , Schwarzbacherová Viera , Galdíková Martina , Koleničová Simona , Halušková Jana , Staničová Jana , Verebová Valéria , Jutková Annamária
Published: August 2021

Chromosomal aberrations and their mechanisms have been studied for many years in livestock. In cattle, chromosomal abnormalities are often associated with serious reproduction-related problems, such as infertility of carriers and early mortality of embryos. In the present work, we review the mechanisms and consequences of the most important bovine chromosomal aberrations: Robertsonian translocations and reciprocal translocations. We also discuss the application of bovine cell cultures in genotoxicity studies.
miR-27b-3p a Negative Regulator of DSB-DNA Repair
Authors: Peraza-Vega Ricardo I. , Valverde Mahara , Rojas Emilio
Published: August 2021

Understanding the regulation of DNA repair mechanisms is of utmost importance to identify altered cellular processes that lead to diseases such as cancer through genomic instability. In this sense, miRNAs have shown a crucial role. Specifically, miR-27b-3 biogenesis has been shown to be induced in response to DNA damage, suggesting that this microRNA has a role in DNA repair. In this work, we show that the overexpression of miR-27b-3p reduces the ability of cells to repair DNA lesions, mainly double-stranded breaks (DSB), and causes the deregulation of genes involved in homologous recombination repair (HRR), base excision repair (BER), and the cell cycle. DNA damage was induced in BALB/c-3T3 cells, which overexpress miR-27b-3p, using xenobiotic agents with specific mechanisms of action that challenge different repair mechanisms to determine their reparative capacity. In addition, we evaluated the expression of 84 DNA damage signaling and repair genes and performed pathway enrichment analysis to identify altered cellular processes. Taken together, our results indicate that miR-27b-3p acts as a negative regulator of DNA repair when overexpressed.
University Students’ Lifestyle Behaviors during the COVID-19 Pandemic: A Four-Wave Longitudinal Survey
Authors: Goncalves Aurélie , Le Vigouroux Sarah , Charbonnier Elodie
Published: August 2021

Many studies have highlighted the impact of lockdowns on the lifestyle of university students. We do not, however, know how these lifestyles have changed over the course of the COVID-19 pandemic. The objective of the present study was to describe changes in the levels of physical activity, sedentary behaviors, and alcohol consumption in French university students during different periods of the pandemic. This cohort study was conducted between 23 April and 11 December 2020. Measurements were performed four times: Twice during two successive lockdowns and twice during the intervening period. A total of 1294 university students were initially included, and 91 students completed the four measurement points over a seven-month period. Alcohol consumption, physical activity, and sedentary behaviors were measured. The results revealed high levels of physical activity during the first lockdown, but a subsequent decline during the pandemic that was partly explained by time. The pandemic had a positive effect on alcohol consumption. Sedentary levels were higher during both lockdowns, and sedentary behaviors tended to persist over time. This study raises concerns about the long-term effects of the pandemic on students’ health and lifestyle. The preponderance of distance learning should be reconsidered, given the negative impact of physical inactivity and sedentary behavior on long-term health, especially in young adults.
Sex Differences and Predictors of In-Hospital Mortality among Patients with COVID-19: Results from the ANCOHVID Multicentre Study
Authors: Fernández-Martínez Nicolás Francisco , Ortiz-González-Serna Rocío , Serrano-Ortiz Álvaro , Rivera-Izquierdo Mario , Ruiz-Montero Rafael , Pérez-Contreras Marina , Guerrero-Fernández de Alba Inmaculada , Romero-Duarte Álvaro , Salcedo-Leal Inmaculada
Published: August 2021

Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan–Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies.
Long-Term Neurological and Psychological Distress Symptoms among Smallholder Farmers in Costa Rica with a History of Acute Pesticide Poisoning
Authors: Farnham Andrea , Fuhrimann Samuel , Staudacher Philipp , Quirós-Lépiz Marcela , Hyland Carly , Winkler Mirko S. , Mora Ana M.
Published: August 2021

Studies suggest that acute pesticide poisonings (APP) may be linked with long-term neurological effects. To examine long-term neurological and psychological distress symptoms associated with having experienced an APP, we conducted a cross-sectional study of 300 conventional and organic smallholder farmers from Zarcero County, Costa Rica, May–August 2016. We collected self-reported data on sociodemographic characteristics, occupational history, pesticide exposure, APPs, neurological and psychological distress symptoms (using the Brief Symptom Inventory (BSI)). Adjusted logistic regression models were fit. A total of 14% of the farmers (98% male) reported experiencing at least one APP during their lifetime. Self-reported APP was associated with neurological symptoms during the 12 months prior to interview (e.g., fainting (Odds Ratio: 7.48, 95% Confidence Interval: 1.83, 30.74), shaking hands (3.50; 1.60, 7.60), numbness/tingling in hands or feet (3.23; 1.66, 6.32), insomnia (2.53; 1.34, 4.79), accelerated heartrate (2.42; 1.03, 5.47), dizziness (2.38; 1.19, 4.72), increased irritability/anger (2.37; 1.23, 4.55), low energy (2.33; 1.23, 4.46), and difficulty concentrating (2.01; 1.05, 3.85)). Farmers who reported an APP in the ten years prior to interview experienced increased odds of abnormal BSI scores for hostility (4.51; 1.16, 17.70) and paranoid ideation (3.76; 0.99, 18.18). Having experienced an APP may be associated with long-term neurological and psychological distress symptoms.
Psychological and Social Effects of Oral Health and Dental Aesthetic in Adolescence and Early Adulthood: An Observational Study
Authors: Militi Angela , Sicari Federica , Portelli Marco , Merlo Emanuele Maria , Terranova Antonella , Frisone Fabio , Nucera Riccardo , Alibrandi Angela , Settineri Salvatore
Published: August 2021

Background: Is well known that oral health and dental aesthetic have significant effects on the sociality of human beings. The aim of the present study was to assess some aspects of oral health with possible repercussions in adolescent and youth, with particular reference to gender differences. Methods: A total of 190 subjects with female prevalence (F = 62.6%, M = 37%) and ages between 14 and 29 years old (Mean = 23.8; SD = 3.27) participated. Evaluation was carried using standardized instruments to assess quality of oral life (PIDAQ), negative impact of oral conditions (OHIP-14), and self-esteem (Rosenberg Self Esteem Scale). Correlational and difference analyses and linear regressions were performed. Results: Significant gender differences were found in terms of gender, in reference to variables such as self-confidence and convictions. Positive correlations emerged between psychological impact and social impact, aesthetic concern and social impact, convictions and self-confidence, oral health with psycho-social impact, and aesthetic concern, self-esteem with oral health. Inverse correlations emerged between psycho-social impact and self-confidence, aesthetic concern and self-confidence, oral health, and self-confidence. Multivariate linear regression indicated relations between age and psychological impact, sex and self-confidence, crooked teeth and conviction. Conclusions: The impact of oral health on the psychological well-being of young people is relevant. These factors, if considered within clinical practice, can improve the quality of life of the subject.
Oral Health Profiling for Young and Older Adults: A Descriptive Study
Authors: Conquest Jennifer Hanthorn , Skinner John , Kruger Estie , Tennant Marc
Published: August 2021

The purpose of this study was to trial the suitability of an oral health promotion toolkit in a chair-side setting to determine: an individual’s knowledge; understanding of oral and general health behaviour and evaluate the commitment of dental practitioners to undertake an assessment of the individual’s attitude and aptitude to undertake a home care preventive plan. All participants were 18 years and over and came from low socio-economic backgrounds in rural New South Wales, Australia. The study evaluated 59 case studies regarding their knowledge of oral and general health. The study included an oral health profiling questionnaire, based on validated oral health promotion outcome measures, a full course of dental care provided by a private dental practitioner or a dental student. Out of the 59 participants, 47% of participants cleaned their teeth twice per day, 69% used fluoride toothpaste and 47% applied the toothpaste over all the bristles. The questionnaire, based on Watt et al. (2004) verified oral health prevention outcome measures was a sound approach to determine an individual’s knowledge, understanding of oral and general health behaviour. However, dental practitioners’ commitment to assessing the individual was low.
Could Caregivers’ Stressful Care Experiences Be Related to Their Attitudes towards Advance Care Planning? A Cross-Sectional Descriptive Study
Authors: Tsai Pei-Yu , Huang Wen-Han , Chang Yu-Jun
Published: August 2021

Previous research has shown that care experiences influence the willingness for advance care planning (ACP). Family caregivers have increased contact with medical providers and procedures in the process of caring, and they have also witnessed the disability and suffering of patients. However, few studies have focused on family caregivers to understand their attitudes towards ACP. The aim of this cross-sectional study was to acknowledge family caregivers’ attitudes towards ACP and the related factors, especially care stress and experiences during the care process. We interviewed 291 family caregivers, and the demographics of the caregivers and care recipients, the clinical condition of care recipients, and the caregivers’ stress and care experiences were collected via anonymous questionnaires. Multiple logistic regression was performed to determine the factors associated with the attitudes towards ACP. We found that the caregiver having private health insurance (p < 0.001) and a completed DNR (p < 0.001) and the experience of recipients admitted to the ICU (p = 0.019) are associated with caregiver’s positive attitudes towards ACP. The greater the stress of conflict within a family over care decisions, the more participants think that ACP is important (p = 0.011). It is suggested that (1) in a family-centered culture, a public strategy for promoting ACP could be to emphasize the benefits of ACP in reducing family conflicts, and (2) when people make financial plans, they should also be provided with information about ACP to enable them to form a more integral plan for their future.
Assessing the Impact of Neighborhood Conditions on Neurodevelopmental Disorders during Childhood
Authors: Santiago Anna Maria , Berg Kristen A. , Leroux Joffré
Published: August 2021

Nearly three out of ten neurodevelopmental disabilities in the United States have been linked to environmental conditions, prompting emerging lines of research examining the role of the neighborhood on children’s developmental outcomes. Utilizing data from a natural experiment in Denver, this study quantifies the impact of exposure to varied neighborhood contexts on the diagnosis of neurodevelopmental disorders over the course of childhood. Our analysis is based upon retrospective child, caregiver, household and neighborhood data derived from the Denver Child Study for a sample of approximately 590 Latino and African American children and youth whose families were quasi-randomly assigned to subsidized housing operated by the Denver (CO) Housing Authority during part of their childhood. We employed binary response models with endogenous explanatory variables, estimated using instrumental variables (IV) probit and average marginal effects to identify predictors of a neurodevelopmental disorder diagnosis during childhood. We found that multiple dimensions of neighborhood context—especially neighborhood socioeconomic status, older housing stock, residential instability and prevalence of neurological hazards in the ambient air—strongly and robustly predicted the diagnosis of a neurodevelopmental disorder during childhood.
Contamination of Hospital Surfaces with Bacterial Pathogens under the Current COVID-19 Outbreak
Authors: Pochtovyi Andrei A. , Vasina Daria V. , Kustova Daria D. , Divisenko Elizaveta V. , Kuznetsova Nadezhda A. , Burgasova Olga A. , Kolobukhina Ludmila V. , Tkachuk Artem P. , Gushchin Vladimir A. , Gintsburg Alexander L.
Published: August 2021

The SARS-CoV-2 pandemic remains a global health issue for several reasons, such as the low vaccination rates and a lack of developed herd immunity to the evolution of SARS-CoV-2, as well as its potential inclination to elude neutralizing antibodies. It should be noted that the severity of the COVID-19 disease is significantly affected by the presence of co-infections. Comorbid conditions are caused not only by pathogenic and opportunistic microorganisms but also by some representatives of the environmental microbiome. The presence of patients with moderate and severe forms of the disease in hospitals indicates the need for epidemiological monitoring of (1) bacterial pathogens circulating in hospitals, especially the ESKAPE group pathogens, and (2) the microbiome of various surfaces in hospitals. In our study, we used combined methods based on PCR and NGS sequencing, which are widely used for epidemiological monitoring. Through this approach, we identified the DNA of pathogenic bacteria (Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, CoNS, and Achromobacter spp.) on various surfaces. We also estimated the microbiome diversity of surfaces and identified the potential reservoirs of infections using 16S rRNA profiling. Although we did not assess the viability of identified microorganisms, our results indicate the possible risks of insufficient regular disinfection of surfaces, regardless of department, at the Infectious Diseases Hospital. Controlling the transmission of nosocomial diseases is critical to the successful treatment of COVID-19 patients, the rational use of antimicrobial drugs, and timely decontamination measures.
Health Promotion in Sport, through Sport, as an Outcome of Sport, or Health-Promoting Sport—What Is the Difference?
Authors: Geidne Susanna , Van Hoye Aurélie
Published: August 2021

What do we currently know about the relationship between health promotion and sport in research [...]
Construction of a Territorial Space Classification System Based on Spatiotemporal Heterogeneity of Land Use and Its Superior Territorial Space Functions and Their Dynamic Coupling: Case Study on Qionglai City of Sichuan Province, China
Authors: Ou Dinghua , Zhang Qi , Wu Yijie , Qin Jing , Xia Jianguo , Deng Ouping , Gao Xuesong , Bian Jinhu , Gong Shangqi
Published: August 2021

Territorial space classification (TSC) provides the basis for establishing systems of national territory spatial planning (NTSP) and supervising their implementation in China, thus has important theoretical and application significance. Most of the current TSC research is related to land use/land cover classification, ignoring the connection of the NTSP policies and systems, failing to consider the spatiotemporal heterogeneity of land use superior territorial space functions (TSFs) and the dynamic coupling between land use and its superior TSFs on the result of TSC. In this study, we integrated the factors influencing the connection of NTSP policies and systems and established a theoretical framework system of TSC from the perspective of spatial form and functional use. By integrating the q-statistic method with spatiotemporal geographical analysis, we propose a method to construct a TSC system for Qionglai City of Sichuan Province in China based on the spatiotemporal heterogeneity of land use superior TSFs and the dynamic coupling between land use and its superior TSFs. It makes up for the deficiency of directly taking land use/land cover classification as TSC and solves the problems of ignoring the spatiotemporal heterogeneity of land use superior TSFs and the dynamic coupling between land use and its superior TSFs. Using this method, we found that the TSC of Qionglai City consists of 3, 7, and 14 first-, second-, and third-level space types, respectively. The key findings from this study are that land use superior TSFs show spatiotemporal heterogeneity in Qionglai, and coupling effects in spatial distribution were noted between land use types and their superior TSFs, as was temporal heterogeneity in the coupling degree and the structure of the TSFs corresponding to the land use types, which show obvious dynamics and non-stationarity of the functional structure. These findings confirm the necessity of considering the spatiotemporal heterogeneity of land use superior TSFs and the dynamic coupling between land use and its superior TSFs in TSC. This method of establishing a TSC system can be used to address a number of NTSP and management issues, and three examples are provided here: (a) zoning of urban, agricultural, and ecological space; (b) use planning of production, living and ecological space; (c) delimitation of urban development boundary, permanent basic farmland protection redline, and ecological protection redline.
Effect of a Virtual Reality-Based Restorative Environment on the Emotional and Cognitive Recovery of Individuals with Mild-to-Moderate Anxiety and Depression
Authors: Li Hongqidi , Dong Wenyi , Wang Zhimeng , Chen Nuo , Wu Jianping , Wang Guangxin , Jiang Ting
Published: August 2021

In this study, restorative environment theory and virtual reality (VR) technology were combined to build different 3D dynamic VR interactive scenes. We discuss the effects of a VR restorative environment on the emotional and cognitive recovery of individuals with mild-to-moderate anxiety and depression. First, we built a VR restorative garden scene, divided into four areas: forest, lawn, horticultural planting, and water features. The scene was verified to have a good recovery effect in 26 participants. Then, 195 participants with mild-to-moderate anxiety and depression were selected as experimental subjects. Through psychological testing and EMG (Electromyography) and EEG (Electroencephalography) data feedback, we further explored the differences in the sense of presence in VR restorative scenes and their effect on individual emotional and cognitive recovery. The results showed that (1) both the restorative environment images and the VR scenes had a healing effect (the reduction in negative emotions and the recovery of positive emotions and cognition), with no difference in the subjective feeling of recovery among the different scenes, but the recovery score of the VR urban environment was higher than that of the natural environment (differing from the results in real environments); (2) a high sense of presence can be experienced in different VR scenes, and interactive activities in VR scenes can provide a great presence experience; (3) the recovery effects of VR restorative environment on emotion and self-efficacy are realized through the presence of VR scenes; (4) a VR restorative environment is helpful for the emotional improvement and cognitive recovery of individuals with mild-to-moderate anxiety and depression. VR urban scenes also have good recovery effects. In terms of cognitive recovery, self-efficacy improved significantly. In addition, from the perspective of EEG indicators, the VR restorative scene experience activated the prefrontal lobe, which is conducive to cognitive recovery in individuals with mild-to-moderate anxiety and depression. In terms of emotional improvement, negative emotions were significantly reduced in the different VR scene groups. In conclusion, we further explored ways to help individuals with mild-to-moderate anxiety and depression, in order to promote the development and application of mental health.
Can Hotel Companies’ Water Conservation Management and Waste Reduction Measures Influence Hotel Customers’ Willingness to Pay More and Intention to Revisit?
Authors: Park Junghyun , Park Yunmi , Yoo Jae Leame , Yu Jongsik
Published: August 2021

This study investigated the effect of hotel water conservation management and waste reduction measures on customers’ social and personal norms, willingness to pay more, and revisit intention, with cost consciousness as a moderating variable. A total of 311 valid samples were obtained by conducting a survey on customers who have used hotels for the past year. To perform the empirical analysis, SPSS 22.0 (IBM, New York, NY, USA) and AMOS 22.0 (IBM, New York, NY, USA) were used. As a result of the analysis, seven of the eight hypotheses were accepted, and the ninth hypothesis that tested the moderating effect was partially accepted. The results of the study revealed that a hotel’s eco-friendly activities had a positive effect on its overall performance. The results also provide insight that can lay the foundation for the sustainable management of hotels.
Lead Pollution, Demographics, and Environmental Health Risks: The Case of Philadelphia, USA
Authors: O’Shea Michael J. , Toupal Jonas , Caballero-Gómez Hasibe , McKeon Thomas P. , Howarth Marilyn V. , Pepino Richard , Gieré Reto
Published: August 2021

Lead (Pb) soil contamination in urban environments represents a considerable health risk for exposed populations, which often include environmental justice communities. In Philadelphia, Pennsylvania (PA), Pb pollution is a major concern primarily due to extensive historical Pb-smelting/processing activity and legacy use of Pb-based paints and leaded gasoline. The U.S. Environmental Protection Agency (USEPA) organized and/or compiled community-driven soil sampling campaigns to investigate Pb content in surface soils across Philadelphia. Using these data (n = 1277), combined with our own dataset (n = 1388), we explored the spatial distribution of Pb content in soils across the city using ArcGIS. While assessing Zone Improvement Plan (ZIP)-code level data, we found strong correlations between factors, such as the percentage of children with elevated blood lead levels (% EBLL) and % minority population as well as between % EBLL and % children in poverty. We developed a “Lead Index” that took demographics, median measured Pb-in-soil content, and % EBLLs into account to identify ZIP codes in need of further assessment. Our results will be used to help lower the Pb-exposure risk for vulnerable children living in disproportionately burdened communities.
Estimation of Years Lived with Disability Using a Prevalence-Based Approach: Application to Major Psychiatric Disease in Korea
Authors: Kim Chae-Bong , Ock Minsu , Jung Yoon-Sun , Kim Ki-Beom , Kim Young-Eun , Kim Keun-A , Yoon Seok-Jun
Published: August 2021

To help develop policies concerning the prevention of psychiatric disease in Korea, we reviewed the literature on this topic in different countries and used a prevalence-based approach to estimate the years lived with disability (YLDs) in Korean patients with major psychiatric diseases. We calculated YLDs by extracting data on the number of patients with mild, moderate, and severe cases of schizophrenia, bipolar disorder, and major depressive disorder, as classified by International Statistical Classification of Disease (ICD) codes. YLDs were highest for patients with major depressive disorder (1190.6; 73.9%), schizophrenia (303.3; 18.8%) and bipolar disorder (117.9; 7.3%). Men had higher YLDs for schizophrenia, 2502 (20–24 years); bipolar disorder, 477 (40–44 years); and major depressive disorder, 2034 (75–79 years). Women had higher YLDs for schizophrenia, 484 (45–49 years); bipolar disorder, 214 (≥80 years); and major depressive disorder, 3541 (75–79 years). The prevalence-based approach and severity distribution is useful for estimating long-term psychiatric disease burden and YLDs. However, YLD-estimation studies must compensate for the shortcomings of the ICD-10 by referencing the Diagnostic and Statistical Manual of Mental Disorders 5th edition, as well as updating the disability weight score according to disease severity.
How Mentally Fatiguing Are Consecutive World Padel Tour Matches?
Authors: Díaz-García Jesús , González-Ponce Inmaculada , López-Gajardo Miguel Ángel , Van Cutsem Jeroen , Roelands Bart , García-Calvo Tomás
Published: August 2021

It is currently unknown whether mental fatigue occurs throughout a WPT competition and whether consecutive matches affect how mentally fatiguing a match is perceived to be. The objective was to quantify the effects of successive professional matches on mental fatigue. A total of 14 professional players (9 males, Mage = 25, 5 females, Mage = 21) participated during qualified rounds of a WPT with three eliminatory matches: Match 1 (morning) and 2 (afternoon) on day 1 (n = 14), Match 3 (morning) on day 2 (n = 6). Mental fatigue and motivation, with scales, and reaction time, with a 3-min Psychomotor Vigilance Test, were measured at two time intervals (pre and post matches (<30 min)). To analyze the evolution of these variables, a two-way repeated measures MANOVA was performed. An increase in mental fatigue from pre- to post-matches was observed (p < 0.01), with an accumulation of mental fatigue between matches played on day 1 (p < 0.01), maximizing the mental fatigue perceived during Match 2. Padel matches impair motivation and reaction time (p = 0.04), without effects between successive matches, which reinforced the idea that mental fatigue may impair padel performance (i.e., reaction time). Coaches should use training interventions and recovery strategies to counteract/avoid the accumulation of mental fatigue during professional tournaments.
Using Realist Evaluation to Understand Process Outcomes in a COVID-19-Impacted Yoga Intervention Trial: A Worked Example
Authors: Haynes Abby , Gilchrist Heidi , Oliveira Juliana S. , Tiedemann Anne
Published: August 2021

Realist evaluation offers a valuable way to understand how interventions function and thus how they can be improved and locally adapted. Consequently, realist evaluation is increasingly conducted in parallel with intervention trials. It comprises a clear philosophical foundation and view of causality, pragmatic mixed data collection methods, and a theory-driven approach in which hypothesised program theories are tested and refined. However, detailed methods for data analysis are seldom well-described in realist studies and no clear method for analysing and presenting realist evaluation data has yet emerged. In this methodological paper we use the worked example of our realist process evaluation of the SAGE yoga trial to illustrate an applied process of data analysis and presentation of findings. We show how we drew on other realist studies for ideas, provide examples of six key tasks involved in conducting a realist process evaluation (including coding data and structuring results) and describe strategies that did not work and our rationale for rejecting them. This detailed account of the decisions and methods that worked for us is intended to provide a practical and informed point of departure for researchers conducting a realist evaluation.
Picky Eating in Children: A Scoping Review to Examine Its Intrinsic and Extrinsic Features and How They Relate to Identification
Authors: Chilman Laine , Kennedy-Behr Ann , Frakking Thuy , Swanepoel Libby , Verdonck Michele
Published: August 2021

The health benefits and importance of family mealtimes have been extensively documented. Picky eating can impact this complex activity and has numerous extrinsic (or external) and intrinsic (or internal) features. Occupational therapists work with children and their families by looking at both intrinsic and extrinsic influences and are therefore well-placed to work within this context. This scoping review comprises a comprehensive search of key health industry databases using pre-determined search terms. A robust screening process took place using the authors pre-agreed inclusion and exclusion criteria. There were 80 studies that met the inclusion criteria, which were then mapped using content analysis. The most common assessments used to identify picky eating relied on parental reports and recall. Often additional assessments were included in studies to identify both the intrinsic and extrinsic features and presentation. The most common reported intrinsic features of the child who is a picky eater included increased sensitivity particularly to taste and smell and the child’s personality. Extrinsic features which appear to increase the likelihood of picky eating are authoritarian parenting, rewards for eating, and pressuring the child to eat. Most commonly reported extrinsic features that decrease the likelihood of picky eating are family meals, responsive parents, and involving the child in the preparation of food. In conclusion, there is a lack of published papers addressing the role of occupational therapists in the assessment and identification of picky eating in children. There appears to be a complex interplay between intrinsic and extrinsic features which impact caregiver responses and therefore on the picky eater.
Eye Health Service Uptake among People with Visual Impairment and Other Functional Difficulties in Bangladesh: A Cross-Sectional Study with Short-Term Follow Up
Authors: Sanders Ruth , Gascoyne Ben , Appleby Paul , Rashida Syeda Asma , Jolley Emma
Published: August 2021

People with visual impairments are disproportionately likely to also have other impairments. However, little is known about whether these other impairments affect access to eye health services. This study among cataract and refractive error patients in four districts in Bangladesh explores the relationship between self-reported difficulties in hearing, mobility, self-care, communication and cognition domains, eye health service uptake, and location of initial eye health assessment. Cataract and refractive errors were diagnosed through ophthalmic clinical assessment, and the Washington Group Short Set (WG-SS) was used to ascertain difficulties in other functional domains. Univariate and multivariate analyses were used to examine the relationship between functional difficulties and uptake of cataract and refractive error services. We found that people with self-reported functional difficulties were less likely to take up refractive error services compared to people with same need but with no functional difficulties, and that they were more than twice as likely to access surgical services after attending an outreach camp compared with a hospital facility. Since a high proportion of people attending eye health assessment services have difficulties in a range of functional domains, strategies to improve the uptake of hospital-based health services are urgently required.