description: The process by which newly synthesized polypeptide chains become their final 3-dimensional protein forms is clearly explained, providing students and researchers of various backgrounds with both a conceptual and technical understanding of the subject. The new Second Edition incorporates thesignificant improvements in the field such as advances in interpreting observed kinetic data, the development of technology to observe fast folding reactions, the molten globule state, and the vital role of chaperone proteins in protein folding. The emphasis on experimental approaches has beenmaintained but this edition does so within the explicit context of simulations and energy surfaces. New discoveries of the central importance of protein folding and unfolding reactions in biology and medicine (including mutation and 'misfolding') are carefully explored. Three case studies elucidatethe difficulties of studying protein folding in vivo.
language: English
title: Mechanisms of Protein Folding
titlecomplete: Mechanisms of Protein Folding (Frontiers in Molecular Biology, 32)
ratings_count: 2
publisher: Oxford University Press