description: Protein structure and design is an area of burgeoning interest. This stems from our being able to create novel proteins at will using the methods of protein engineering and the potential of such proteins in a host of applications ranging from pharmaceuticals to environmentally friendly insecticides. At the same time enormous advances in techniques such as X-ray crystallography, NMR and computer-based modeling are enabling us to define protein structure and properties an undertake redesign with increased assurance. The focus of this volume is on the use of biophysical techniques and computer modeling to characterize protein structure, dynamics and function. Up-to-the-minute accounts of protein NMR, protein dynamics, and computational methods in protein design appear alongside the application of optical specotroscopies to unravel the complexities of structure, function and dynamics. Major topics highlighted include: + Recent developments in 2D and 3D NMR spectroscopy + Assignment of proton resonances for large proteins + Isotopic labeling + Molecular dynamics of peptides from NMR studies + Combined experimental and theoretical approaches to protein dynamics + Pico to femtosecond time spans in optical spectroscopy for protein structure studies. This volume is based on the symposium `Expanding Frontiers in Polypeptide and Protein Structural Research' held in Whistler, British Columbia, Canada in July 1990. It was widely felt that the invited presentations by about 60 of the leading experts in NMR, protein dynamics, spectroscopy and modeling defined the state of the art. Their written contributions appear in this volume.
language: English
title: Proteins: Structure, Dynamics and Design
titlecomplete: Proteins: Structure, Dynamics and Design
publisher: Springer