num_pages: 248
description: Hardbound. Non-insulin dependent diabetes mellitus (NIDDM) is a metabolic disorder characterized by abnormal glucose metabolism. Currently, there is no investigative study that is possible in humans. However, animal models do provide an opportunity to study this problem. This book presents a current comprehensive review of what is known about the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a recently discovered excellent animal model for human NIDDM. It provides valuable opportunities to study diabetes mellitus and gives us precious clues to grasp the nature of diabetes mellitus in humans. To fulfill this purpose, a model animal should bear a close resemblance to humans in respect to the nature of the disease. The OLETF rat, a genetic model of spontaneous development of NIDDM, exhibits hyperglycemic obesity with hyperinsulinemia and insulin resistance similar to those in humans. Implementing preventive measure is difficult in humans but th
language: English
title: Obesity and Niddm: Lessons from the Oletf Rat
titlecomplete: Obesity and Niddm: Lessons from the Oletf Rat
publisher: Elsevier Science Ltd