Mobile Contingency Management for Concurrent Abstinence From Alcohol and Smoking
Condition: Smoking Cessation; Alcohol Drinking
MeSH terms: Alcohol Drinking
Intervention: Nicotine Replacement Therapy; Bupropion; Cognitive Behavioral Treatment; Mobile Contingency Management; Mobile Monitoring
Intervention description: Participants will be prescribed NRT patch and one nicotine rescue method (e.g., nicotine gum, lozenge, inhaler) for use during the post-quit phase of the study. Participants will be given the choice between nicotine gum or nicotine lozenge, and will be instructed to use the rescue method as needed to reduce cigarette cravings; All participants who are medically eligible will be prescribed bupropion, which they will start two weeks prior to their quit day. Dosage will be 150 mg/daily for days 1-7 and 300 mg/daily (administered in two daily doses) until the 6-month follow-up.; Participants will receive 4 60-minute sessions of CBT telephone counseling for alcohol and smoking cessation.; Participants will be asked to provide video recordings of themselves taking carbon monoxide readings in order to confirm smoking abstinence, and breathalyzer to confirm abstinence from alcohol. Participants are asked to upload these videos to the study's secured server, and are provided monetary reward for videos that suggest smoking abstinence and alcohol abstinence.; Participants will be asked to provide video recordings of themselves taking carbon monoxide readings and breathalyzer. Participants are asked to upload these videos to the study's secured server, and are provided monetary reward for providing the video recordings, regardless of abstinence.
Intervention MeSH terms: Bupropion; Nicotine
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 45.0
Sex: All
Minimum age: 18 Years
Maximum age: 80 Years
Healthy volunteers: No

Summary:

      Alcohol misuse and smoking constitute two of the three leading preventable causes of death in
      the United States. The purpose of this research study is to develop an intervention designed
      to help people stop drinking alcohol and stop smoking at the same time.
    

Eligibility criteria:

        Inclusion Criteria:

          -  currently meet criteria for DSM-5 mild to moderate alcohol use disorder (meeting 2-5
             criteria for AUD)

          -  have been engaging in hazardous drinking over the past month, defined as either
             exceeding a mean of 14 standard drinks/wk for men, 7 drinks/wk for women; or by
             consuming >5 on at least one occasion in the last month for men, >4 drinks on at least
             one occasion in the last month for women

          -  currently smoke >10 cigarettes a day, and have smoked for at least one year

          -  can speak and write fluent conversational English

          -  are willing to make an attempt to quit both alcohol and smoking

        Exclusion Criteria:

          -  are expected to have unstable medication regimen during the study

          -  are currently receiving non-study behavioral treatment for alcohol use disorder or
             smoking

          -  have severe alcohol use disorder (meeting >6 criteria for AUD or having alcohol
             withdrawal symptom criterion)

          -  have AUD that is in early remission, with no symptoms evident over the past month

          -  have experienced myocardial infarction in past 6 months

          -  contraindication to nicotine replacement therapy with no medical clearance to
             participate in the study

          -  use other forms of nicotine such as cigars, pipes, or chewing tobacco

          -  are currently pregnant

          -  have a primary psychotic disorder or current manic episode

          -  have had substance use disorder (other than alcohol or nicotine) in the preceding 3
             months

          -  are currently imprisoned or in psychiatric hospitalization