Topical Antibiotic Prophylaxis for Eyelids
Condition: Antibiotic Side Effect; Eyelid; Wound; Eyelid Diseases; Surgical Wound Infection; Surgical Wound, Recent; Surgical Incision; Skin Cancer Face; Antibiotic Allergy; Surgical Site Infection
MeSH terms: Infections; Communicable Diseases; Surgical Wound Infection; Wound Infection; Eyelid Diseases; Wounds and Injuries; Surgical Wound
Intervention: Topical Antibiotic Product; Topical Non-Antibiotic Ointment
Intervention description: Topical antibiotic ointment will be erythromycin or bacitracin. If the patient cannot obtain either (e.g. lack of availability at the pharmacy), bacitracin polymyxin will be prescribed. Allergy to all 3 study drugs means that a patient will be excluded from the study.; Mineral oil/petrolatum-based artificial tear ointment.
Intervention MeSH terms: Anti-Bacterial Agents; Erythromycin; Bacitracin
Phase: Phase 4
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Patients will be randomized to one of two intervention arms (i.e. antibiotic ointment vs. placebo artificial tear ointment) and will not at any point cross over to the other arm.
Masking: None (Open Label)
Masking description: Randomization to one of two intervention arms (i.e. antibiotic ointment vs. placebo artificial tear ointment) will be performed prior to study recruitment by REDCap software. Patients' randomization assignments will be revealed at the initial pre-operative visit or at time that procedure consent is obtained; the study team will not be aware of a subject's randomization assignment prior to that time.
Enrollment: 401.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The investigators propose a prospective randomized control trial testing the hypothesis that
      routine topical antibiotic prophylaxis does not significantly reduce the rate of infection
      after eyelid surgery.
    

Eligibility criteria:

        Inclusion Criteria:

        Patients aged 18 and older who are undergoing various eyelid procedures in an office,
        ambulatory care center, or operating room including but not limited to:

          -  blepharoplasty (upper and lower lids);

          -  ectropion repair;

          -  entropion repair;

          -  external dacryocystorhinostomy;

          -  external levator resection;

          -  eyelid lesion removal and/or biopsy;

          -  eyelid reconstruction and defect repair including after Mohs surgery;

          -  fat pad excision (upper and lower lids);

          -  gold or platinum weight implantation;

          -  internal levator resection;

          -  lateral tarsal strip;

          -  orbital fracture repair requiring periorbital incisions;

          -  orbitotomy requiring periorbital incisions;

          -  tarsorrhaphy;

          -  wedge excision.

          -  Patients undergoing repeat procedures will also be included.

        Exclusion Criteria:

          -  Patients aged younger than 18 years old who are undergoing the above eyelid procedures
             in an office, ambulatory care centers, operating rooms;

          -  patients undergoing chalazion removal;

          -  patients who have had previous wound infections at the site of the procedure;

          -  patients with oral or IV antibiotic use within 10 days prior to procedure;

          -  patients requiring IV antibiotics during the procedure;

          -  patients with grossly contaminated or inflamed wounds;

          -  patients with human or animal bites, patients with wounds resulting from trauma

          -  patients allergic to all study drug options.