This Study Aims to Determine the Long-term Persistence of Antibodies Against Hepatitis B and to Evaluate the Immunogenicity and Safety of Hepatitis B Vaccine in Adolescents Vaccinated in Infancy With Infanrix™ Hexa
Condition: Hepatitis B
MeSH terms: Hepatitis A; Hepatitis B; Hepatitis
Intervention: Engerix™-B Kinder
Intervention description: Single dose administered intramuscularly in deltoid region of non-dominant arm.
Phase: Phase 4
Study type: Interventional
Primary purpose: Prevention
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 301.0
Sex: All
Minimum age: 12 Years
Maximum age: 13 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Infanrix™ hexa; Hepatitis B antibodies; Immunogenicity; Hepatitis B; Adolescents; Infancy; Engerix™-B Kinder; Safety

Summary:

      The purpose of this study is to assess the long-term persistence of immunity to hepatitis B
      in adolescents aged 12-13 years who were vaccinated with four doses of Infanrix™-Hexa in
      infancy and to assess the anamnestic response, immunogenicity, safety and reactogenicity of a
      single challenge dose of the hepatitis B vaccine Engerix™-B Kinder.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Subjects' parent(s)/LAR(s) who, in the opinion of the investigator, can and will
             comply with the requirements of the protocol (e.g. completion of the diary cards,
             return for follow-up visit).

          -  A male or female between the ages of 12 to 13 (from and including the 12th birthday,
             up to but excluding the 14th birthday) at the time of enrolment.

          -  Subjects with documented evidence of previous vaccination with four consecutive doses
             of Infanrix hexa as part of routine vaccination in Germany: three doses of primary
             vaccination received by 9 months of age and one booster dose received between 11 and
             18 months of age.

          -  Written informed consent obtained from the parents/LAR(s) of the subject.

               -  In addition to the informed consent that will be signed by the parents/LAR(s),
                  written informed assent of the subject will be sought.

          -  Healthy subjects as established by medical history and clinical examination before
             entering into the study.

          -  Female subjects of non-childbearing potential may be enrolled in the study.

               -  Non-childbearing potential is defined as pre-menarche, current tubal ligation,
                  hysterectomy, ovariectomy or post-menopause.

          -  Female subjects of childbearing potential may be enrolled in the study, if the
             subject:

               -  has practiced adequate contraception for 30 days prior to vaccination, and

               -  has a negative pregnancy test on the day of vaccination, and

               -  has agreed to continue adequate contraception during the entire treatment period
                  and for 2 months after completion of the vaccination series.

        Exclusion Criteria:

          -  Child in care.

          -  Use of any investigational or non-registered product (drug or vaccine) other than the
             study vaccine within 30 days preceding the dose of study vaccine, or planned use
             during the study period.

          -  Administration of long-acting immune-modifying drugs at any time during the study
             period (e.g. infliximab).

          -  Chronic administration (defined as more than 14 days in total) of immunosuppressants
             or other immune-modifying drugs within six months prior to the vaccination. Inhaled
             and topical steroids are allowed.

          -  Administration of any chronic drug therapy to be continued during the study period.

          -  Planned administration/administration of a vaccine not foreseen by the study protocol
             during the period starting from 30 days before and ending 30 days after the HBV
             challenge dose, with the exception of tetanus toxoid, reduced diphtheria toxoid and
             acellular pertussis (dTpa) vaccine, which can be given as part of routine vaccination
             practice.

          -  Concurrently participating in another clinical study, at any time during the study
             period, in which the subject has been or will be exposed to an investigational or a
             non-investigational vaccine/product (pharmaceutical product or device).

          -  Evidence of previous hepatitis B booster vaccination since administration of the
             fourth dose of Infanrix hexa booster in the second year of life.

          -  History of or intercurrent hepatitis B disease.

          -  Hepatitis B vaccination at birth.

          -  Any confirmed or suspected immunosuppressive or immunodeficient condition, based on
             medical history and physical examination (no laboratory testing required).

          -  Family history of congenital or hereditary immunodeficiency.

          -  History of any reaction or hypersensitivity likely to be exacerbated by any component
             of the vaccine.

          -  Major congenital defects or serious chronic illness including thrombocytopenia and
             bleeding disorders.

          -  History of any neurological disorders or seizures.

          -  Acute disease and/or fever at the time of enrolment.

               -  Fever is defined as temperature ≥ 37.5°C for oral, axillary or tympanic route, or
                  ≥ 38.0°C on rectal route. The preferred route for recording temperature in this
                  study will be axillary.

               -  Subjects with a minor illness (such as mild diarrhoea, mild upper respiratory
                  infection) without fever may, be enrolled at the discretion of the investigator.

          -  Acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal
             functional abnormality, as determined by physical examination or laboratory screening
             tests

          -  Administration of immunoglobulins and/or any blood products within the 3 months
             preceding the dose of study vaccine or planned administration during the study period.

          -  Pregnant or lactating female.

          -  Female planning to become pregnant or planning to discontinue contraceptive
             precautions.