An Abuse Potential Study of Orally Administered HORIZANT in Healthy, Non-dependent, Recreational Drug Users
Condition: Abuse Potential
Intervention: Placebo; Alprazolam 2 mg; Gabapentin Enacarbil Immediate Release (GE-IR) 200 mg; Gabapentin Enacarbil Immediate Release (GE-IR) 450 mg; Gabapentin Enacarbil Immediate Release (GE-IR) 700 mg
Intervention description: Placebo; Oral dose of alprazolam 2 mg; Oral dose of GE-IR 200 mg; Oral dose of GE-IR 450 mg; Oral dose of GE-IR 700 mg
Intervention MeSH terms: Gabapentin; Alprazolam
Phase: Phase 4
Study type: Interventional
Primary purpose: Other
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 86.0
Sex: All
Minimum age: 18 Years
Maximum age: 55 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The purpose of this study is to assess the abuse potential of gabapentin enacarbil in healthy
      adult, non-dependent, recreational drug users.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Provision of signed and dated informed consent form (ICF),

          2. Stated willingness to comply with all study procedures and availability for the
             duration of the study,

          3. Male or female, between 18 and 55 years of age, inclusive,

          4. Current nondependent, recreational drug user who has used sedative drugs for
             recreational (nontherapeutic) purposes (i.e., for psychoactive effects) at least 10
             times in the subject's lifetime and at least once in the 12 weeks before screening,

          5. Body mass index (BMI) within 18.0 kg/m^2 to 36.0 kg/m^2, inclusive,

          6. If female, meets 1 of the following criteria:

               1. If of childbearing potential agrees to use 1 of the accepted contraceptive
                  regimens from at least 30 days prior to the first study drug administration,
                  during the study, and for at least 30 days after the last dose of the study drug.
                  An acceptable method of contraception includes 1 of the following:

                    -  Abstinence from heterosexual intercourse,

                    -  Hormonal contraceptives (birth control pills,
                       injectable/implantable/insertable hormonal birth control products,
                       transdermal patch),

                    -  Intrauterine device (IUD; with or without hormones), Or

               2. If of childbearing potential agrees to use a double barrier method (e.g., condom
                  and spermicide) during the study and for at least 30 days after the last dose of
                  study drug. Or

               3. If of non-childbearing potential, defined as surgically sterile (i.e., has
                  undergone complete hysterectomy, bilateral oophorectomy, or tubal ligation) or is
                  in a postmenopausal state (i.e., at least 1 year without menses without an
                  alternative medical condition and confirmed follicle stimulating hormone (FSH) ≥
                  40 milli-International unit/mL (mIU/mL) prior to the first study drug
                  administration),

          7. If male and engaging in sexual activity that has the risk of pregnancy must agree to
             use a double barrier method (e.g., condom and spermicide) and agree to not donate
             sperm during the study and for at least 90 days after the last dose of the study
             medication, a male who has a pregnant partner shall be excluded,

          8. Healthy, as determined by no clinically significant findings from medical history,
             physical examination, 12-lead ECG, vital signs or clinical laboratory (including
             hematology, clinical chemistry, urinalysis, and serology [screening visit only]) at
             screening visit and admission, as applicable, in the opinion of an investigator,

          9. Negative Coronavirus disease 2019 (Covid-19) test prior to each admission, as
             applicable.

        Exclusion Criteria:

          1. History of significant hepatic, renal, cardiovascular, pulmonary, hematologic,
             neurological, psychiatric, gastrointestinal, endocrine, immunologic, ophthalmologic,
             or dermatologic disease of any etiology (including infections),

          2. Presence or history of significant gastrointestinal, liver or kidney disease, or
             surgery that may affect drug bioavailability with the exception that cholecystectomy
             is permitted at the discretion of an investigator,

          3. Presence of any significant respiratory illness or presence or history of chronic
             respiratory disease (e.g., upper respiratory illness, sleep apnea, emphysema, asthma)
             at screening (subjects with acute respiratory illness may be rescheduled upon
             resolution at the discretion of an investigator),

          4. Personal or family history (first degree relatives) of allergy, hypersensitivity, or
             drug rash with eosinophilia and systemic symptoms (DRESS) syndrome to gabapentin
             enacarbil, gabapentin or any drug product including anti-convulsants (e.g.,
             alprazolam, carbamazepine) or related drugs (e.g., other benzodiazepines) or known
             excipients of any of the drug products in this study (e.g., lactose),

          5. History of sensitivity to or poor tolerance of gabapentin enacarbil, gabapentin,
             pregabalin, or alprazolam,

          6. Female who is lactating at screening,

          7. Female who is pregnant according to the pregnancy test at screening or prior to the
             first study drug administration or planning to become pregnant within 30 days
             following the last study drug administration,

          8. History of substance or alcohol dependence (excluding nicotine and caffeine) within
             the past 2 years, as defined by the Diagnostic and Statistical Manual of Mental
             Disorders, 4th Edition (DSM-IV), and/or subject has been in a drug or alcohol
             rehabilitation program within the last 2 years,

          9. Subjects with positive urine drug screen (UDS) results at screening and admission will
             be assessed for inclusion at the discretion of an Investigator. If
             tetrahydrocannabinol (THC) is positive at admission to the Qualification phase and
             Treatment phase, as applicable, a cannabis intoxication evaluation will be done by an
             investigator and subjects may be permitted to continue in the study, rescheduled, or
             discontinued at the discretion of an investigator. Other positive test results should
             be reviewed to determine if the subject may be rescheduled, in the opinion of the
             investigator,

         10. Is a heavy smoker (>20 cigarettes per day or nicotine-equivalent) and/or is unable to
             abstain from smoking or unable to abstain from the use of prohibited
             nicotine-containing products for at least 1 hour before and 6 hours after study drug
             administration (including e-cigarettes, pipes, cigars, chewing tobacco, nicotine
             topical patches, nicotine gum, or nicotine lozenges),

         11. Regularly consumes excessive amounts of caffeine or xanthines within 30 days prior to
             screening, defined as greater than 6 servings (1 serving is approximately equivalent
             to 120 mg of caffeine) of coffee, tea, cola, or other caffeinated beverages per day,

         12. History of suicidal ideation within 24 months or suicidal behaviour within 2 years of
             screening, showing suicidal tendency as per the Columbia Suicide Severity Rating Scale
             (C-SSRS) administered at screening, or is currently at risk of suicide in the opinion
             of an investigator,

         13. Presence of clinically significant ECG abnormalities at the screening visit, as
             defined by medical judgment, Note: QT corrected according to Fridericia's formula
             (QTcF) interval of >450 msec in male subjects or >470 msec in female subjects will be
             exclusionary. The ECG may be repeated once for confirmatory purposes if the initial
             value obtained exceeds the limits specified,

         14. Has creatinine clearance ≤60 ml/min as calculated by the Cockcroft-Gault equation,

         15. Any history of tuberculosis,

         16. Positive screening results to human immunodeficiency virus (HIV) 1 and 2 antibodies,
             hepatitis B virus surface antigen (HBsAg) or hepatitis C virus antibody (HCV Ab)
             tests,

         17. Intake of an investigational product (IP) within 30 days or 5 times the half-life
             (whichever is longer) prior to screening,

         18. Use of any prescription drugs (with the exception of hormonal contraceptives or
             hormone replacement therapy) in the 30 days prior to the first study drug
             administration, that in the opinion of an investigator would put into question the
             status of the subject as healthy,

         19. Use of over-the-counter (OTC) products (including herbal preparations and supplements)
             within 7 days prior to the first study drug administration, with the exception of
             ibuprofen or acetaminophen,

         20. Donation of plasma in the 7 days prior to screening,

         21. Blood donation (excluding plasma) of approximately 500 mL of blood in the 56 days
             prior to screening,

         22. Is, in the opinion of an investigator or designee, considered unsuitable or unlikely
             to comply with the study protocol for any reason,

         23. Poor venous access at screening, as judged by an investigator.