Compare Pharmaceutical Economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia
Condition: Elective Laparoscopic Surgery
Intervention: Sevoflurane Inhalational Induction and Maintenance; Propofol Target Controlled Infusion for Induction and Maintenance; Propofol Target Controlled Infusion for Induction and Sevoflurane Inhalation for Maintenance
Intervention description: Sevoflurane was administered at a concentration of 8% via vital capacity induction and sevoflurane 0.8-1.5 minimum alveolar concentration (MAC) with a rate of 1 L/min fresh gas flow for maintenance.; Propofol IV 4 ug/mL was administered with target controlled infusion (TCI) for induction and propofol 3 to 6 ug/mL was administered with TCI for maintenance.; Propofol was administered as a bolus IV dose of 1.5 mg/kg for induction at a rate of 40 mg/10 seconds. During maintenance, a sevoflurane concentration of 0.8-1.5 minimal alveolar concentration (MAC) was administered at a rate of 1 L/min fresh gas flow.
Intervention MeSH terms: Propofol; Sevoflurane
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 336.0
Sex: All
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: No
Keywords: Sevoflurane; Propofol; Economics; Pharmaceutical; Chinese

Summary:

      This study is being performed to compare the cost of anesthetic techniques with sevoflurane
      (low fresh gas flow balanced anesthesia) versus propofol (target controlled infusion [TCI])
      versus propofol induction and sevoflurane maintenance anesthesia in subjects undergoing
      elective laparoscopic surgery with predicted anesthesic use between 1 and 3 hour duration.
    

Eligibility criteria:

        Inclusion Criteria

          1. Men or women, aged from 18 to 65

          2. ASA (American Society of Anesthesiologists) physical status (a requirement of the
             subject's physical status): I or II

          3. Body mass index (weight/height^2) from 16 to 30 kg/m^2

          4. Elective laparoscopic surgery requiring general anesthesia managed with endotracheal
             intubation

          5. Duration of anesthesia use will be greater than or equal to 1 hour, but less than 3
             hours in length.

        Exclusion Criteria

          1. Hypersensitivity or unusual response to any halogenated anesthetics.

          2. History of significant cardiovascular, pulmonary, hepatic, renal, central nervous
             system or muscular disease.

          3. Pre-operative cognitive dysfunction or disabling neuropsychiatric disorders.

          4. Need for emergency surgery or surgery requiring additional regional anesthetic
             techniques.

          5. Need for intracranial surgery, cardio-surgery or thoracic surgery.

          6. Subjects inability to cooperate with the anesthetist before administration of the
             anesthetic agent.

          7. Personal or familial history of malignant hyperthermia.

          8. Females who are either pregnant or breast feeding.