Does Pharmacological Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adults Enhance Parenting Performance?
Condition: ADHD
MeSH terms: Attention Deficit Disorder with Hyperactivity
Intervention: lisdexamfetamine
Intervention description: 3 week with-in subject lead in phase to find optimal dose ranging from 30 mg to 70mg
Intervention MeSH terms: Lisdexamfetamine Dimesylate
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Enrollment: 38.0
Sex: All
Minimum age: 18 Years
Maximum age: 55 Years
Healthy volunteers: No
Keywords: parenting

Summary:

      It is now well recognized that Attention-Deficit/Hyperactivity Disorder (ADHD) is a chronic
      disorder of childhood that extends into adulthood for many individuals. A number of
      impairments in daily life functioning have been identified in adults with ADHD, including
      marital distress, risky driving, and using less effective parenting practices (e.g., Barkley,
      2006).

      Specifically, some parents with ADHD have been found to use inconsistent discipline, less
      parental involvement, and less positive reinforcement with their children compared to parents
      without ADHD (e.g., Chen & Johnston, 2007; Chronis-Tuscano, Clarke, Rooney, Diaz, & Pian,
      2008). While there is some evidence that stimulant medication improves parental functioning
      for adults with ADHD, only one study has specifically explored the use of stimulant
      medication and parenting(Chronis-Tuscano, Seymour, Stine, Jones, Jiles, Rooney, et al.,
      2008).

      The purpose of this study is to explore whether or not the stimulant medication,
      lisdexamfetamine, improves parent functioning. Measures of parenting behavior, parental
      psychosocial functioning, and child psychosocial functioning will be collected. It is
      hypothesized that lisdexamfetamine will be associated with some improvement in these
      assessments.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Parents with a diagnosis of ADHD, who also have a child with an ADHD between the ages
             of 5-16

        Exclusion Criteria:

          -  Parents with any of the following: any identified structural heart abnormality or
             other health condition that significantly affects heart performance (e.g.,
             hypertension), a resting systolic blood pressure ≥140 and diastolic blood pressure
             ≥90, pregnant or breast feeding, significant psychiatric problems other than ADHD that
             currently require medication or any emergent psychiatric treatment,
             medical/psychiatric illness that could be worsened by stimulants (such as a seizure
             disorder, Tourette's Disorder or hyperthyroidism), or alcohol or substance abuse
             problems in the past 6 months.

          -  Children with any of the following: any psychiatric problem other than ADHD,
             Oppositional Defiant Disorder (ODD), or Conduct Disorder (CD) that requires medication
             or any emergent psychiatric treatment, either parent or child has participated in the
             same parent-child interaction task used in this study in the last 6 months, either as
             part of a study or a clinical treatment.