Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking
Condition: Bladder Cancer; Cervical Cancer; Esophageal Cancer; Gastric Cancer; Head and Neck Cancer; Kidney Cancer; Leukemia; Liver Cancer; Lung Cancer; Pancreatic Cancer; Tobacco Use Disorder
MeSH terms: Lung Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Uterine Cervical Neoplasms; Urinary Bladder Neoplasms; Esophageal Neoplasms; Liver Neoplasms; Tobacco Use Disorder
Intervention: smoking cessation intervention; bupropion hydrochloride; gene expression analysis; polymerase chain reaction; counseling intervention; educational intervention; psychosocial assessment and care
Intervention MeSH terms: Bupropion
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Enrollment: 540.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: bladder cancer; cervical cancer; esophageal cancer; gastric cancer; renal cell carcinoma; adult primary liver cancer; non-small cell lung cancer; small cell lung cancer; pancreatic cancer; hypopharyngeal cancer; laryngeal cancer; lip and oral cavity cancer; nasopharyngeal cancer; oropharyngeal cancer; paranasal sinus and nasal cavity cancer; adult acute myeloid leukemia; tobacco use disorder

Summary:

      RATIONALE: A stop-smoking plan that includes health education counseling and bupropion may
      help African-American smokers stop smoking. It is not yet known whether health education
      counseling is more effective with or without bupropion in helping African Americans stop
      smoking.

      PURPOSE: This clinical trial is studying health education counseling and bupropion to see how
      well they work compared with a placebo and health education counseling in helping African
      Americans smokers stop smoking.
    

Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  African American who has smoked ≤ 10 cigarettes per day for ≥ 2 years AND has smoked
             for ≥ 25 days within the past month

               -  Not a heavy smoker

               -  No other forms of tobacco within the past 30 days

          -  Must be interested in stopping smoking

          -  No other smoker in the household enrolled in this study

        PATIENT CHARACTERISTICS:

          -  Has a home address and a functioning telephone number

          -  Not planning to move from the Kansas City metro area within the next 12 months

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  No alcohol or substance abuse within the past year

          -  Not currently drinking ≥ 14 alcoholic drinks per week

          -  No binge drinking (5 or more drinks on one occasion) on at least two occasions within
             the past month

          -  No history of seizures or head trauma

          -  No history of bulimia or anorexia nervosa

          -  No myocardial infarction within the past 30 days

          -  No reported use of opiates, cocaine, or stimulants

          -  No diabetes requiring oral hypoglycemics or insulin

        PRIOR CONCURRENT THERAPY:

          -  More than 30 days since prior nicotine replacement therapy, fluoxetine, clonidine,
             buspirone, or doxepin

          -  No other concurrent medication that contains bupropion hydrochloride

          -  No concurrent psychoactive medications