Study of Fluzone® Influenza Virus Vaccines 2012-2013 Formulation Among Adults.
Condition: Influenza
MeSH terms: Influenza, Human
Intervention: Influenza Virus Vaccine: Fluzone® 2012-2013 Formulation; Influenza Virus Vaccine: Fluzone® Intradermal 2012-2013 Formulation; Influenza Virus Vaccine: Fluzone® 2012-2013 Formulation; Influenza Virus Vaccine: Fluzone® High-Dose 2012-2013 Formulation
Intervention description: 0.5 mL, Intramuscular; 0.1 mL, Intradermal; 0.5 mL, Intramuscular; 0.5 mL, Intramuscular
Intervention MeSH terms: Vaccines
Phase: Phase 4
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Enrollment: 200.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Influenza; Influenza virus vaccine; Fluzone® (Influenza Virus Vaccine) 2012-2013 Formulation; Fluzone® High-Dose (Influenza Virus Vaccine) 2012-2013 Formulation; Trivalent Inactivated Influenza Vaccine; Fluzone® Intradermal (Influenza Virus Vaccine) 2012-2013 Formulation

Summary:

      The aim of this study is to evaluate the safety and immunogenicity of Fluzone vaccine (18
      years to <65 years of age and ≥ 65 years of age), Fluzone Intradermal vaccine (18 years to
      <65 years of age), and Fluzone High-Dose vaccine (≥ 65 years of age).

      Primary Objective:

        -  To describe the safety of the 2012 - 2013 formulation of Fluzone and Fluzone Intradermal
           vaccines in adults 18 to < 65 years of age and the safety of the 2012 - 2013 formulation
           of Fluzone and Fluzone High-Dose vaccines in adults ≥ 65 years of age.

      Observational Objectives:

        -  To describe the immunogenicity of the 2012 - 2013 formulation of Fluzone and Fluzone
           Intradermal vaccines in adults 18 to < 65 years of age and the immunogenicity of the
           2012 - 2013 formulation of Fluzone and Fluzone High-Dose vaccines in adults ≥ 65 years
           of age.

        -  To evaluate the compliance, in terms of immunogenicity, of each study vaccine (Fluzone,
           Fluzone Intradermal, and Fluzone High-Dose) in the applicable age group with the
           requirements of the Committee for Human Medicinal Products (CHMP) Note for Guidance
           (NfG) CPMP/BWP/214/96.

        -  To submit remaining available sera from subjects given Fluzone vaccine to the Center for
           Biologics Evaluation and Research (CBER) for further analysis by the World Health
           Organization (WHO), the Centers for Disease Control and Prevention (CDC), and the Food
           and Drug Administration (FDA) to support selection and recommendation of strains for
           subsequent years' influenza vaccines.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Subject is ≥ 18 years of age on the day of inclusion

          -  Informed consent form has been signed and dated

          -  Able to attend all scheduled visits and to comply with all trial procedures.

        Exclusion Criteria:

          -  History of serious adverse reaction to any influenza vaccine

          -  Receipt of any vaccine within 30 days before receiving study vaccine, or plans to
             receive another vaccine before Visit 2

          -  Participation in another interventional clinical trial investigating a vaccine, drug,
             medical device, or medical procedure in the 30 days preceding the first study
             vaccination or during the course of the study, unless no intervention for the other
             study occurred within the 30 days prior to the first study vaccination and none are
             planned before the subject would complete safety surveillance for the present study

          -  Thrombocytopenia, which may be a contraindication for intramuscular vaccination, at
             the discretion of the Investigator

          -  Prior vaccination with any 2012 - 2013 formulation of influenza vaccine

          -  Known systemic hypersensitivity to eggs, chicken proteins, latex, or any of the
             vaccine components, or a history of a life-threatening reaction to Fluzone, Fluzone
             Intradermal, or Fluzone High-Dose vaccine or to a vaccine containing any of the same
             substances (the complete list of vaccine components is included in the Prescribing
             Information)

          -  Receipt of immune globulins, blood, or blood-derived products in the past 3 months

          -  Bleeding disorder or receipt of anticoagulants in the 3 weeks preceding inclusion,
             which may be a contraindication for intramuscular vaccination, at the discretion of
             the Investigator

          -  Subject is pregnant, or lactating, or of childbearing potential (to be considered of
             non-childbearing potential, a female must be pre-menarche or post-menopausal for at
             least 1 year, surgically sterile, or using an effective method of contraception or
             abstinence from at least 4 weeks prior to vaccination and until at least 4 weeks after
             vaccination)

          -  Any condition that in the opinion of the Investigator would pose a health risk to the
             subject if enrolled or could interfere with the evaluation of the vaccine

          -  Personal history of Guillain-Barré syndrome

          -  Known or suspected congenital or acquired immunodeficiency; or receipt of
             immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy,
             within the preceding 6 months; or long-term systemic corticosteroid therapy
             (prednisone or equivalent for more than 2 consecutive weeks within the past 3 months)

          -  Chronic illness that, in the opinion of the Investigator, is at a stage where it might
             interfere with trial conduct or completion

          -  Seropositivity for human immunodeficiency virus (HIV), hepatitis B, or hepatitis C, as
             reported by the subject

          -  Deprived of freedom by an administrative or court order, or in an emergency setting,
             or hospitalized involuntarily

          -  Current alcohol or drug addiction that, in the opinion of the Investigator, might
             interfere with the ability to comply with trial procedures

          -  Moderate or severe acute illness/infection (according to Investigator judgment) or
             febrile illness (temperature ≥ 100.4°F) on the day of vaccination. A prospective
             subject should not be included in the study until the condition has resolved or the
             febrile event has subsided

          -  Identified as an Investigator or employee of the Investigator or study center with
             direct involvement in the proposed study, or identified as an immediate family member
             (i.e., parent, spouse, natural or adopted child) of the Investigator or employee with
             direct involvement in the proposed study.