Studying the Effects of Phentermine on Eating Behavior
Condition: Obesity
Intervention: Phentermine; placebo
Intervention description: After 7 days of phentermine 37.5 mg administration, food intake should be less than after 14 days of placebo.; Food intake as measured by a laboratory study should be greater after 7 days of placebo administration compared to seven days of phentermine administration.
Intervention MeSH terms: Phentermine
Phase: Phase 4
Study type: Interventional
Primary purpose: Other
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Enrollment: 13.0
Sex: All
Minimum age: 18 Years
Maximum age: 60 Years
Healthy volunteers: No

Summary:

      The goal of this study is to determine whether one week of phentermine compared to placebo
      administration results in changes in food intake during a laboratory meal.
    

Eligibility criteria:

        Inclusion Criteria:

          -  BMI between 30-40kg/m2

          -  Stable weight (+5 lbs) for a minimum of 3 months

          -  Systolic Blood Pressure <140mm Hg

          -  Diastolic Blood Pressure <90 mm Hg

          -  Pulse <95 beats per minute

          -  English language proficiency

        Exclusion Criteria:

          -  Previous unsuccessful trial of phentermine

          -  Prior adverse reaction to phentermine

          -  On any antidepressant medications,especially monoamine oxidase inhibitors(MAOI)

          -  History of neurological disorder (e.g. dementia)

          -  History of moderate or severe head injury

          -  Current or past history of coronary artery disease

          -  Current or past history of stroke or transient ischemic attack

          -  Current or past history of heart arrhythmias

          -  Current of past history of congestive heart failure

          -  Current or past history of peripheral artery disease

          -  Current or past history of liver disease

          -  Current or past history of kidney disease

          -  Uncontrolled diabetes mellitus (type I or II)

          -  Narrow-angle glaucoma

          -  Hypo- or hyper-thyroidism not adequately treated

          -  On medications (prescribed or OTC) known to affect appetite (e.g. diet pills), weight,
             or metabolism

          -  Current or past history (within the past 12 months) of major depression

          -  Current or past history (past 12 months) of alcohol or drug abuse or dependence

          -  Current or past history (lifetime) of amphetamine abuse or dependence

          -  Known history of learning disorder or developmental disability

          -  Current or past Attention Deficit Hyperactivity Disorder (ADHD)

          -  Pregnancy, planning to become pregnant, or lactation within the previous 6 months

          -  Waist circumference greater than 188cm

          -  Indwelling metallic object (e.g., pacemaker,pump), non-removable metal jewelry,
             medicinal patch or recent metallic ink tattoo

          -  Significant claustrophobia

          -  Current or past history of anorexia nervosa,bulimia nervosa (within the past 12
             months) or binge eating disorder (within the previous 6 months)