Effect of Lidocaine and Esmolol to Improve the Quality of Recovery
Condition: Pain; Constipation; Nausea; Vomiting
MeSH terms: Constipation; Vomiting
Intervention: Lidocaine; Esmolol; Lidocaine + Esmolol (Combo)
Intervention description: Pre-Induction: Lidocaine Loading: 1 mg/kg After Induction:Lidocaine Infusion: 12.5-25 mcg/kg/min 0.75-1.5 mg/kg/h); Esmolol Pre-Induction: Loading dose 750 mcg/Kg (0.75 mg/kg) Esmolol Post Induction: Infusion dose 7.5 - 15 mcg /kg/min; Pre-induction: Lidocaine Loading dose(1 mg/kg) + Esmolol Loading dose(750 mcg/Kg)
Maintenance Infusion rate after Induction:
Lidocaine(12.5-25 mcg/kg/min) + Esmolol(7.5-15 mcg/kg/min)
Intervention MeSH terms: Lidocaine; Esmolol
Phase: Phase 4
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Factorial Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 32.0
Sex: All
Minimum age: 18 Years
Maximum age: 80 Years
Healthy volunteers: No
Keywords: Lidocaine Infusion; Esmolol Infusion; Anesthetic adjuvant; Abdominal surgery; Pain management; Hemodynamic stability; Perioperative outcomes

Summary:

      The purpose of this prospective, randomized, double-blinded, active-controlled study is:

      To assess the effectiveness of systemic administration of lidocaine and esmolol in
      combination (vs. either drug alone) will result in improved postoperative outcomes for
      patients undergoing abdominal surgery (e.g., less pain and postoperative constipation, nausea
      and vomiting, faster return of bowel function, resumption of normal activities of daily
      living), leading to a shorten length of hospital stay, maintaining hemodynamic stability
      during general anesthesia, when administered as intravenous adjuvants
    

Eligibility criteria:

        Inclusion Criteria:

          -  Patients scheduled to undergo abdominal surgical procedures

          -  Willingness and ability to sign an informed consent document

          -  No allergies to anesthetic or analgesic medications

          -  18 - 80 years of age

          -  American Society of Anesthesiologists (ASA) physical status classification: Class I -
             III adults of either sex

          -  Women of childbearing potential must be currently practicing an acceptable form of
             birth control, and have a negative urine or blood pregnancy test

          -  Patients with systolic blood pressure greater than 80 and less than 150 at baseline,
             diastolic blood pressure less than 100 at baseline.

        Exclusion Criteria:

          -  Inability to comprehend the pain assessment tools.

          -  Patients with known allergy, hypersensitivity or contraindications to anesthetic or
             analgesic medications

          -  Patients with clinically-significant medical conditions, such as brain, heart, kidney,
             endocrine, or liver diseases,

          -  Peptic ulcer disease or bleeding disorders

          -  Patients with history of hepatic, renal, cardiac failure, organ transplant, or
             diabetes

          -  Patients with reactive airway disease (asthma)

          -  Patients with seizures

          -  Chronic use of ß-blocker or calcium channel blocker

          -  Morbid obesity (body mass index >40)

          -  Pregnant or lactating women

          -  Subjects with a history of alcohol or drug abuse within the past 3 months

          -  Any other conditions or use of any medication which may interfere with the conduct of
             the study