Study to Evaluate the Effect of a Nu Skin Product and Device for Brown Spots
Condition: Hyperpigmentation
MeSH terms: Hyperpigmentation
Intervention: Nu Skin Product; Cosmetic instrument; Tretinoin cream 0.05; CeraVe moisturizer
Intervention description: Thin layer of Nu Skin product applied to face.; Cosmetic instrument with topical Nu Skin product. Thin layer of Nu Skin product applied to face followed by galvanic, used for 3 minutes.; Thin layer of tretinoin applied to face.; Thin layer of CeraVe applied to face.
Intervention MeSH terms: Tretinoin
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Enrollment: 80.0
Sex: Female
Minimum age: 25 Years
Maximum age: 55 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The purpose of this study is to determine whether a topical Nu Skin product with or without a
      galvanic spa device improves brown spots on the face. The Nu Skin product will be compared to
      an over the counter moisturizer and tretinoin cream.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Able to understand and sign informed consent.

          -  Able to complete study and comply with study procedures.

          -  Caucasian female ages 25-55.

          -  Presence of photodamage and lentigines of II-III on the Glogau Photoaging

          -  Must be willing to avoid laser and light treatments, treatments with filler, chemical
             peels, microdermabrasion, Botox or any other cosmetic treatment to the face during the
             duration of the study.

          -  Must be willing to avoid changing topical moisturizers and cosmetics during the study.

          -  Able to stop any alpha or beta hydroxy acids, topical retinol or retinoid derivatives,
             topical antioxidants, or any topical product that may interfere with the study 2 weeks
             prior to the study.

        Exclusion Criteria:

          -  Cosmetic treatment of face, such as laser or light treatment, filler, Botox,
             microdermabrasion, or chemical peels 6 months prior to study or during study.

          -  Current smoker.

          -  Pregnant, nursing, or planning to become pregnant during study.

          -  Currently taking drugs including oral retinoids or any other medication with a known
             clinically significant drug interaction with topical tretinoin.

          -  Known hypersensitivity to retinoids. History of severe retinoid dermatitis.

          -  History of substance abuse, mental dysfunction, or other factors limiting ability to
             cooperate with study.

          -  Concurrent participation in another clinical study or participation 30 days prior to
             enrollment that includes exposure to an investigational drug that would interfere with
             this study.

          -  Any disease or condition which would interfere with study participation or unduly
             increase risk.

          -  Presence of an electrically sensitive support system such as a pacemaker.

          -  Known history of epilepsy.

          -  Presence of metal implants or metal braces on teeth.