Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications
Condition: Acne Vulgaris
MeSH terms: Acne Vulgaris
Intervention: clindamycin and benzoyl peroxide; Dapsone gel
Intervention description: Daily applications, to the randomized side of the face either left or right, of clindamycin and benzoyl peroxide; Twice-daily applications of dapsone gel
Intervention MeSH terms: Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Dapsone; Benzoyl Peroxide
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Enrollment: 53.0
Sex: All
Minimum age: 18 Years
Maximum age: 45 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      This is a randomized, half-face study. On 1 side of the face, the subject will apply 1 of the
      2 test products, clindamycin and benzoyl peroxide or dapsone gel and the contra lateral side
      of the face will remain non-treated to serve as a control.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Capable of understanding and willing to provide signed and dated written voluntary
             informed consent (and any local or national authorization requirements) before any
             protocol specific procedures are performed.

          -  Male and female subjects aged from 18 to 45 years at time of consent.

          -  Has a Fitzpatrick Skin Type of I, II, or III.

          -  Is willing to discontinue use of all facial products (other than the cleanser provided
             and makeup or razor and facial shave product) on the face for the 3 days before their
             baseline/day 0 visit and use only the provided facial products and their normal makeup
             or razor and facial shaving product for the duration of the study.

          -  Is willing to not change brands of makeup or razor and facial shave product during the
             study.

          -  Is willing to refrain from using any facial product on the face other than study
             products and their normal makeup or razor and facial shave product for the duration of
             the study.

          -  Is willing to refrain from exercising prior to their instrument appointments.

          -  Is willing to refrain from showering or drinking caffeinated beverages within 1 hour
             prior to their instrument visits.

          -  Is willing to report to the site for each visit with a clean face and no makeup.

          -  Is willing to avoid sunburn, tanning, tanning beds or other excessive sun exposure.
             Understands that if their skin tone changes significantly during the study it will be
             necessary to discontinue their participation.

          -  Able to complete the study and to comply with study instructions.

          -  Sexually active females of childbearing potential participating in the study must
             agree to use a medically acceptable method of contraception while receiving
             protocol-assigned product. A woman of childbearing potential is defined as one who is
             biologically capable of becoming pregnant; including perimenopausal women who are less
             than 2 years from their last menses.

        Exclusion Criteria:

          -  Female subjects who are pregnant, trying to become pregnant, or breast feeding.

          -  Male subjects that have facial beards (mustache and/or goatee is acceptable).

          -  Is a Type I diabetic.

          -  Has active or chronic skin allergies.

          -  Has a history of acute or chronic disease that might interfere with, or increase the
             risk of study participation.

          -  Has participated in other facial studies in the preceding 30 days or other clinical
             studies in preceding 14 days.

          -  Had skin cancer treatment in preceding 12 months.

          -  Has damaged skin on facial areas (eg, from sunburn, tattoos, scars).

          -  Had any medical procedure (e.g., laser resurfacing, chemical peels, plastic surgery)
             to facial areas in preceding 12 months.

          -  Had any cosmetic procedure (e.g., microdermabrasion, etc.) to facial areas within 8
             weeks of the baseline visit.

          -  Use of topical retinoids or related agents for the treatment of acne or photoaging in
             the preceding 6 months.

          -  Live in the same household as currently enrolled subjects.

          -  Employees of investigator/clinical research organization (CRO) or Stiefel Laboratories
             involved in the study, or an immediate family member (partner, offspring, parents,
             siblings or sibling's offspring) of an employee involved in the study.

          -  Any other condition or factor the investigator or his duly assigned representative
             believes may affect the skin response or the interpretation of the test results.