A One Year Open Label Study Assessing the Safety and Tolerability of Vilazodone in Patients With Major Depressive Disorder (MDD)
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Intervention: vilazodone
Intervention description: titration to 40 milligrams (mg) every day (qd) for 1 year
Intervention MeSH terms: Vilazodone Hydrochloride
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 616.0
Sex: All
Minimum age: 18 Years
Maximum age: 70 Years
Healthy volunteers: No

Summary:

      This open label 52-week clinical trial is designed to assess the safety and tolerability of
      vilazodone and to analyze genetic markers of response to vilazodone in adult patients
      diagnosed with MDD. This study will enroll approximately 600 patients.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Males or females 18-70 years of age.

          -  Meets Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text
             Revision (DSM-IV-TR) criteria for Major Depressive Disorder.

          -  Hamilton Depression Rating Scale (HAM-D) score ≥ 18 on the first 17 items of the
             21-item HAM-D at Screening and Baseline Visits.

          -  Patients must have general ocular health.

        Exclusion Criteria:

          -  Patients with a history of schizophrenia, schizoaffective disorder or bipolar I or II
             disorder (with a history of hypomanic or manic episodes).

          -  Patients who meet DSM-IV-TR criteria for substance abuse or dependence within 1 year
             of the Baseline visit.

          -  Patients who, in the Investigator's judgment, pose a serious suicidal or homicidal
             risk or have made a suicide attempt within 6 months prior to Screening Visit.

          -  Patients who are taking psychotropic drugs. Patients who have taken psychotropic drugs
             must have discontinued these prior to Screening Visit.

          -  Patients taking migraine medications with a serotonergic mechanism of action.

          -  Patients taking Cytochrome P450 3A4 (CYP3A4) inhibitors such as grapefruit juice,
             ketoconazole, diltiazem, and macrolide antibiotics.

          -  Patients with a known hypersensitivity to selective serotonin reuptake inhibitors
             (SSRIs) or 5-hydroxytryptamine 1a (5-HT1a) agonists.

          -  Patients previously treated with vilazodone.

          -  Patients taking Chantix or St. John's Wort.

          -  Presence of significant acute or chronic medical disorders by history or physical
             exam.

          -  Patients with a history of seizure disorders.

          -  Prior history of malignancy if patient has <5 year survival OR completed treatment <1
             year prior to enrollment and is currently without evidence of recurrence.

          -  Skin cancers other than malignant melanoma will be permitted.

          -  Patients with evidence of other central nervous system disorders including psychosis,
             delirium, dementia and amnesic disorders.

          -  Patients with renal impairment or hepatic impairment.

          -  Patients who are not euthyroid.

          -  Patients with any serious medical or neurological disorder or condition that make it
             unlikely that the patient could complete one year of treatment or would otherwise
             preclude the administration of study medication.

          -  Female patients must not be pregnant, not lactating, and not planning to become
             pregnant during the time of study participation. All female patients who are not at
             least 1 year post menopausal or irreversibly surgically sterilized must be using
             adequate and reliable contraception throughout the trial.

          -  Patients with clinically significant ECG abnormalities which, as determined by the
             investigator, make it unlikely that the patient would complete one year of treatment
             or would otherwise preclude treatment with vilazodone.

          -  Patients having clinically significant abnormal laboratory findings.

          -  Patients with a positive drug screen.

          -  Patients who, in the opinion of the investigator, would be noncompliant with the visit
             schedule or study procedures.

          -  Patients that have taken an investigational drug or participated in an investigational
             drug trial within the past 30 days.