Zevalin-beam for Aggressive Lymphoma
Condition: Non-Hodgkin's Lymphoma
MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin
Intervention: ibritumomab tiuxetan; BEAM chemotherapy and autologous stem-cell transplantation
Intervention description: 0.4 mCi/kg
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 60.0
Sex: All
Minimum age: 18 Years
Maximum age: 70 Years
Healthy volunteers: No
Keywords: non-Hodgkin's lymphoma; autologous stem cell transplantation; radioimmunotherapy; zevalin

Summary:

      The study hypothesis is that the addition of zevalin radioimmunotherapy to the conditioning
      regimen given prior to BEAM high-dose chemotherapy and autologous stem cell transplantation
      in patients with aggressive lymphoma will reduced disease recurrence rate and improve overall
      and disease-free survival.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Patients with CD20 positive diffuse large B-cell lymphoma as confirmed by a
             pathological biopsy report.

          2. Patients who are candidates for autologous stem-cell transplantation due to primary
             refractory or first relapse of disease.

          3. Patients must have chemo-sensitive disease achieving at least partial response (Cheson
             2007 criteria) to last chemotherapy.

          4. Age ≥ 18 years and age ≤ 70

          5. Patients with adequate autologous stem cell collection for transplantation (target ≥
             2.5 x 106 CD34+ cells/kg).

          6. Patients must sign written informed consent.

          7. Adequate birth control in fertile patients.

          8. All prior chemotherapy completed at least three weeks before study treatment.

          9. Marrow involvement less than 25% at transplantation, no limitation on blood counts
             (low platelet count allowed).

         10. Negative HIV antibody.

        Exclusion Criteria:

          1. 1. Chemo-refractory disease as determined by less than partial response (Cheson 2007
             Criteria) to last chemotherapy.

          2. Two or more relapses after initial response to induction chemotherapy.

          3. High-grade transformation from earlier diagnosis of low-grade lymphoma. Patients with
             "De Novo" Transformed DLBCL, defined as DLBCL only on lymph node biopsy and a
             discordant marrow with para-trabecular small cells at first diagnosis of lymphoma, are
             eligible if adherent all other selection criteria.

          4. Bilirubin > 3.0 mg/dl, transaminases > 3 times upper normal limit.

          5. Creatinine > 2.0 mg/dl.

          6. ECOG Performance status > 2.

          7. Uncontrolled infection.

          8. Pregnancy or lactation.

          9. Abnormal lung diffusion capacity (DLCO < 40% predicted).

         10. Severe cardiovascular disease; New York Heart Association (NYHA) Functional
             Classification ≥2.

         11. Active CNS disease involvement.

         12. Presence of any other malignancy or history of prior malignancy within 5 years of
             study entry. Within 5 years, patients treated for Stage I or II cancers are eligible
             provided they have a life expectancy > 5 years in relation to this prior malignance.
             The 5-year exclusion rule does not apply to-non melanoma skin tumors and in situ
             cervical cancer.

         13. Pleural effusion or ascites > 1 liter.

         14. Known hypersensitivity to rituximab.

         15. Psychiatric conditions/disease that impair the ability to give informed consent or to
             adequately co-operate.

         16. Prior radioimmunotherapy.

         17. Prior autologous or allogeneic HSCT.

         18. Active evidence of Hepatitis B or C infection; Hepatitis B surface antigen positive.

         19. Patients who have had prior radiation to the lung will be excluded from the study,
             although mediastinal irradiation will be permitted if minimal lung is in the treatment
             volume.

         20. Patients who have received >500cGy radiation to the kidneys will be excluded from the
             study.