Efficacy and Safety of Tildrakizumab in the Treatment of Scalp Psoriasis
Condition: Scalp Psoriasis
MeSH terms: Psoriasis
Intervention: PART 1: Double-blind Placebo-controlled; PART 2: Double-blind Active Treatment Extension
Intervention description: all eligible subjects will receive either tildrakizumab or placebo; subjects initially on placebo will be switched over to receive tildrakizumab while subjects initially on tildrakizumab will continue to receive tildrakizumab as per defined schedule
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Enrollment: 231.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This is a multicenter, randomized, double-blind, placebo-controlled study to assess the
      efficacy and safety of tildrakizumab in the treatment of moderate to severe psoriasis of the
      scalp.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Subjects should be 18 years or older at the time of signing the informed consent
             during the Screening visit.

          2. Subjects with a clinical diagnosis of chronic plaque psoriasis of at least 6 months
             (as determined by-subject interview and confirmation of diagnosis through physical
             examination by Investigator).

          3. Subjects must have moderate to severe plaque psoriasis of the scalp at Screening and
             at Baseline, defined by:

               -  Scalp Investigator Global Assessment (IGA) of ≥3

               -  Psoriasis Scalp Severity Index (PSSI) score of ≥12

               -  ≥30% or scalp surface area affected.

          4. Subject must have moderate to severe plaque psoriasis at Screening and Baseline
             defined by

               -  Physician Global Assessment for Skin (PGA-S) of at least moderate severity (score
                  of ≥3 on a 5-pointer scale)

               -  PASI score of ≥12

               -  Body Surface Area (BSA) involvement of >10%

          5. Subjects must be considered candidates for systemic therapy, meaning scalp psoriasis
             inadequately controlled by topical treatments (corticosteroids), and/or phototherapy,
             and/or previous systemic therapy.

          6. Subjects has a negative evaluation for tuberculosis (TB) within 4 weeks before
             initiating study treatment, defined as a negative QuantiFERON® test. Subjects with a
             positive or 2 successive indeterminate. QuantiFERON® tests are allowed if they have
             all of the following:

               -  No history of active TB or symptoms of TB.

               -  A posterior-anterior chest radiogram (with associated report available at study
                  center) performed within 3 months of Screening with no evidence of active TB (or
                  of any other pulmonary infectious diseases).

               -  If prior latent TB infection (LTBI), must have history of adequate prophylaxis
                  (per local standard of care).

               -  If presence of LTBI is established, then treatment according to local country
                  guidelines must have been followed for 4 weeks prior to inclusion in the study.

             A maximum of 2 QuantiFERON® tests are allowed. A re-test is only permitted if the
             first is indeterminate; the result of the second test will then be used.

          7. Subjects are unlikely to conceive, as indicated by at least one "Yes" answer to the
             following questions:

               -  Subject is a male.

               -  Subject is a female and agrees to abstain from heterosexual activity OR use a
                  highly effective method of contraception as per Appendix 7.

               -  Male subjects with female partners of childbearing potential who are not using
                  birth control as described above must use a barrier method of contraception (eg,
                  condom) if not surgically sterile (ie, vasectomy).

               -  Subject is a surgically sterilized female or is documented to be postmenopausal.
                  For contraceptive guidance see Appendix 7.

          8. For women of childbearing potential, a negative serum pregnancy test at Screening and
             a negative urine pregnancy test within 24 hours prior to Day 1 and on subsequent
             visits at which study treatment doses are scheduled.

          9. Subjects must have results of a physical examination within normal limits or
             clinically acceptable limits to the Investigator prior to Day 1. The Investigator is
             encouraged to consult with the Medical Monitor (or appropriate designee) if there are
             questions regarding the significance of any out-of-range values.

         10. Subjects must be capable of giving signed informed consent as described in Appendix 2,
             which includes compliance with the requirements and restrictions listed in the ICF and
             in this protocol.

        Exclusion Criteria:

          1. Subjects who have laboratory abnormalities at Screening including any of the
             following:

               -  Alanine aminotransferase or aspartate aminotransferase ≥2.5 × the upper limit of
                  normal

               -  Creatinine ≥2 × the upper limit of normal

               -  Serum direct bilirubin ≥1.5 mg/dL

               -  White blood cell count <3.0×103/μL

               -  Any other laboratory abnormality, which, in the opinion of the Investigator, will
                  prevent the subject from completing the study or will interfere with the
                  interpretation of the study results.

          2. Subjects who have predominantly non-plaque forms of psoriasis specifically
             erythrodermic psoriasis, predominantly pustular psoriasis, medication-induced or
             medication-exacerbated psoriasis, or new-onset guttate psoriasis.

          3. Women of childbearing potential who are pregnant, intend to become pregnant (within 6
             months of completing the study), or are lactating.

          4. Subjects with any infection or history of recurrent infection requiring treatment with
             systemic antibiotics within 2 weeks prior to Screening, or severe infection (eg,
             pneumonia, cellulitis, bone or joint infections) requiring hospitalization or
             treatment with intravenous (IV) antibiotics within 6 weeks prior to Screening.

          5. Subjects with any previous use of tildrakizumab or other IL-23/Th-17 pathway
             inhibitors, including p40, p19 and IL-17 antagonists for psoriasis.

             • Prior use of TNF-alpha inhibitors with a wash-out period of 12 weeks would be
             allowed. However, the number of subjects with prior use of TNF-alpha inhibitors would
             be capped at 40% and the analysis will be stratified based on prior use of these
             biologics.

          6. Subjects with a positive human immunodeficiency virus test result, hepatitis B surface
             antigen, or hepatitis C virus test result.

          7. Subjects with a prior malignancy or concurrent malignancy (excluding successfully
             treated basal cell carcinoma, squamous cell carcinoma of the skin in situ, squamous
             cell carcinoma of skin with no evidence of recurrence within 5 years or carcinoma in
             situ of the cervix that has been adequately treated).

          8. Subjects who have received live viral or bacterial vaccination within 4-weeks prior to
             Baseline or who intend to receive live viral or bacterial vaccination during the
             study.

          9. Subjects who are currently participating in another interventional clinical study or
             has participated in an interventional clinical study within 5-half-lives (of the drug)
             to wash-out prior to randomization (Subjects participating in observational studies or
             non-interventional registry studies may be included in the study).

         10. Subjects or a family member is among the personnel of the study center or
             Sponsor/designee staff directly involved with this study.

         11. Subjects who have any concomitant medical condition which in the opinion of the
             Investigator could affect the study outcome or present an unacceptable risk.

         12. Subjects who were hospitalized due to an acute cardiovascular event (such as
             myocardial infarction, cerebrovascular accident, cardiovascular illness [eg, angina
             pectoris], or cardiovascular surgery [such as coronary artery bypass grafting]) within
             6 months before Screening.

         13. Subjects who, in the opinion of the Investigator, will not be a reliable participant
             in the study and those who can confound the results of the study.

         14. Subjects who have a history of alcohol or drug abuse in the previous year.

         15. Subjects who have high risk of suicidality at the Screening assessment based on
             Investigator's judgment or, if appropriate, as indicated by a response of "yes" within
             the last 12 months to Questions 4 or 5 in the suicidal ideation section, or any
             positive response in the behavioral section of the Columbia-Suicide Severity Rating
             Scale

         16. Subjects with any other clinically significant laboratory abnormality, which, in the
             opinion of the Investigator, will prevent the subject from completing the study or
             will interfere with the interpretation of the study results.