Efficacy and Safety Evaluation of Sintilimab in Patients With Advanced or Metastatic Non-squamous NSCLC
Condition: Lung Neoplasms
MeSH terms: Lung Neoplasms
Intervention: Sintilimab; Pemetrexed; Platinum; Placebos
Intervention description: 10 mL:100 mg，200mg，Q3W (qualer 3 weeks), day1, I.V.; 500mg/m^2; Q3W (qualer 3 weeks), day1, I.V.; Q3W (qualer 3 weeks), day1, I.V.; first 4 cycles.; 10 mL:100 mg，200mg，Q3W (qualer 3 weeks), day1, I.V.
Intervention MeSH terms: Pemetrexed
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 397.0
Sex: All
Minimum age: 18 Years
Maximum age: 75 Years
Healthy volunteers: No

Summary:

      Efficacy and Safety Evaluation of IBI308 in Patients with advanced or metastatic Non-squamous
      NSCLC
    

Eligibility criteria:

        Inclusion criteria

          1. Sign written informed consent before any trial-related processes are implemented;

          2. Age ≥ 18 years and <75 years;

          3. Life expectancy exceeds 3 months;

          4. The investigator confirmed at least one measurable lesion according to RECIST 1.1.

             A measurable lesion located in the field of previous radiation therapy or after local
             treatment may be selected as a target lesion if it is confirmed to have progressed;

          5. According to the International Lung Cancer Research Association and the American
             Association for the Classification of Cancer Classification, the 8th edition of the
             TNM (Tumor Node Metastasis) staging of lung cancer, a histologically or cytologically
             confirmed locally advanced (IIIB/IIIC phase) that cannot be treated surgically and
             cannot undergo radical concurrent chemoradiotherapy, Patients with metastatic or
             recurrent (stage IV) non-squamous NSCLC;

          6. Confirmed for patients with EGFR (Epidermal growth factor receptor) or ALK (Anaplastic
             lymphoma kinase) targeted therapy (documentary evidence of no tumor EGFR-sensitive
             mutations and no ALK gene rearrangement)

          7. The Eastern Cancer Cooperative Group (ECOG) has a performance score of 0 or 1;

          8. Have not received any systematic anti-tumor treatment for advanced disease; The
             patient may have received adjuvant chemotherapy as long as the disease relapses at
             least 6 months after the last dose of chemotherapy is completed;

          9. Adequate hematologic function, defined as absolute neutrophil count ≥1.5×10^9 /L,
             platelet count ≥100 ×10^9 /L, hemoglobin ≥9g/dL (no blood transfusion or
             erythropoietin (EPO) within 7 days) Dependency);

         10. Adequate liver function, defined as total bilirubin levels ≤ 1.5 times normal upper
             limit (ULN) and aspartate aminotransferase (AST) and alanine aminotransferase (ALT)
             levels ≤ 2.5 times ULN in all patients, or for recorded liver Patients with
             metastasis, AST and ALT levels ≤ 5 times ULN;

         11. Adequate renal function, defined as serum creatinine ≤ 1.5 times ULN or measured or
             calculated creatinine clearance ≥ 60 ml / min (Cockcroft-Gault formula);

         12. Coagulation function is adequate, defined as international normalized ratio (INR) or
             prothrombin time (PT) ≤ 1.5 times normal upper limit (ULN); if the subject is
             receiving anticoagulant therapy, as long as the PT is used in anticoagulant drugs
             Within the scope;

         13. Female subjects of childbearing age should be negative for urine or serum pregnancy
             test within 72 hours prior to the first study drug administration (Day 1, Day 1). If
             the urine pregnancy test results are positive or cannot be confirmed as negative, a
             blood pregnancy test is required.

         14. If there is a risk of conception, male and female patients are required to use
             high-efficiency contraception (ie, an annual failure rate of less than 1%) and
             continue until at least 180 days after stopping the trial treatment; Note: If
             abstinence is the usual lifestyle of the subject and the preferred method of
             contraception, abstinence can be accepted as a method of contraception.

        Exclusion criteria:

          1. Histological squamous cell-dominated NSCLC; Mixed cell types must distinguish between
             dominant cell morphology, and if small cell types are present, the subject is not
             eligible for inclusion;

          2. Currently participating in interventional clinical research or treatment, or receiving
             other research drugs or using research equipment within 4 weeks before the first dose;

          3. Previously received the following therapies: anti-PD-1, anti-PD-L1 or anti-PD-L2 drugs
             or against another stimulatory or synergistic inhibition of T cell receptors [eg
             CTLA-4 (Cytotoxic T lymphocyte antigen-4), OX-40 (also called CD134, cluster of
             differentiation134), CD137] agent;

          4. Received a traditional Chinese medicine with anti-tumor effect, or an immunomodulatory
             drug (thymosin, interferon, interleukin) within 2 weeks before the first dose, or
             received major surgery within 3 weeks before the first dose;

          5. Pulmonary radiation therapy of >30 Gy within 6 months prior to the first dose;

          6. Completed palliative radiotherapy within 7 days prior to the first dose;

          7. Clinical active diverticulitis, abdominal abscess, gastrointestinal obstruction and
             peritoneal metastasis;

          8. Have received a physical organ or blood system transplant;

          9. There is clinically uncontrollable pleural effusion/peritoneal effusion;

         10. known to have severe allergic reactions (≥3 grade) to the active ingredients of
             Sintilimab, pemetrexed, cisplatin, carboplatin and or any excipients;

         11. Active autoimmune diseases requiring systemic treatment (eg, using a disease-modifying
             drug, corticosteroid or immunosuppressant) within 2 years prior to the first dose.
             Alternative therapies (such as thyroxine, insulin, or physiological corticosteroids
             for adrenal or pituitary insufficiency) are not considered systemic treatments;

         12. Diagnosis of immunodeficiency or study of systemic steroid therapy or any other form
             of immunosuppressive therapy within 7 days prior to the first dose of study.

             Physiological doses of corticosteroids (≤10 mg/day of prednisone or equivalent) are
             permitted;

         13. Has not fully recovered from the toxicity and/or complications caused by any
             intervention before starting treatment (ie, ≤1 or reaching baseline, excluding fatigue
             or alopecia);

         14. Other malignant tumors were diagnosed within 5 years prior to the first dose, with the
             exception of radical cutaneous basal cell carcinoma, cutaneous squamous cell
             carcinoma, and/or radically resected carcinoma in situ;

         15. Active central nervous system (CNS) metastasis and / or cancerous meningitis. Patients
             with treated brain metastases who have remained clinically stable for at least 2 weeks
             and have no new or advanced brain metastases may be enrolled and discontinued hormone
             therapy 3 days prior to the first study drug. Patients with known untreated,
             asymptomatic brain metastases can be enrolled, but regular imaging assessments of the
             brain must be performed.

         16. There is a history of (non-infectious) pneumonia requiring steroid therapy or the
             presence of interstitial lung disease 1 year before the first dose;

         17. There are active infections that require systemic treatment;

         18. Subjects who are unable or unwilling to receive folic acid or vitamin B12
             supplementation;

         19. There are known cases of mental illness or substance abuse that may have an impact on
             compliance with the test requirements;

         20. A history of human immunodeficiency virus (HIV) infection (ie, HIV 1/2 antibody
             positive) is known.

         21. Untreated active hepatitis B;

             Note: Controlled (treated) hepatitis B subjects also meet the inclusion criteria if
             the following criteria are met:

             At least 4 weeks of HBV (Hepatitis B virus) antiviral therapy must have been received
             prior to the first dose of study drug, and the HBV viral load is <1000 copies/ml (200
             IU/ml). Subjects who are receiving HBV therapy and have a viral load of <1000
             copies/ml (200 IU/ml) should receive antiviral therapy throughout the study treatment
             period.

             For subjects with anti-HBc (hepatitis B core antigen)(+), HBsAg(-), anti-HBs(-), and
             HBV viral load (-), prophylactic anti-HBV therapy is not required, but viral
             reactivation is closely monitored;

         22. Active HCV (Hepatitis C virus)-infected subjects (HCV antibody positive and HCV-RNA
             levels above the lower limit of detection);

         23. Vaccination of live vaccine within 30 days before the first dose (1st cycle, 1st day);
             Note: Inactivated virus vaccines for seasonal influenza, injectable drugs are
             permitted; however, live attenuated influenza vaccines (such as FluMist®) are not
             allowed for intranasal administration;

         24. There may be a history of illness or disease evidence, treatment or laboratory
             abnormalities that may interfere with the subject's full participation in the study,
             or the investigator believes that participating in the study is not in the best
             interests of the subject, including dialysis.