Immunogenicity and Safety Study of GSK Biologicals' Fluviral® (2008 - 2009 Season) in Adults Over 18 Years
Condition: Influenza Vaccines
MeSH terms: Influenza, Human
Intervention: Fluviral®
Intervention description: One intramuscular injection into the deltoid region of the non-dominant arm
Phase: Phase 3
Study type: Interventional
Primary purpose: Prevention
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 110.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Fluviral; Influenza

Summary:

      This study will evaluate the immunogenicity and safety of GSK Biologicals' Trivalent split
      virion influenza vaccine Fluviral for the 2008-2009 season in adults over the age of 18.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Subjects who the investigator believes can and will comply with the requirements of
             the protocol.

          -  Male and female adults, 18 to 60 years of age and over 60 years of age.

          -  Written informed consent obtained from the subject.

          -  Satisfactory baseline medical assessment by history and physical examination.

          -  Comprehension of the study requirements, ability to comprehend and comply with
             procedures for collection of safety data, expressed availability for the required
             study period, and ability and willingness to attend scheduled visits.

        Exclusion Criteria:

          -  Acute disease at the time of enrollment.

          -  Significant acute or chronic, uncontrolled medical or psychiatric illness.

          -  Any confirmed or suspected immunosuppressive condition including:

               -  History of human immunodeficiency virus (HIV) infection,

               -  Cancer or treatment for cancer, within 3 years of study enrollment. Persons with
                  a history of cancer who are disease-free without treatment for 3 years or more
                  are eligible.

          -  History of renal impairment.

          -  History of hepatic dysfunction due to hepatitis B, C or toxins including alcohol.

          -  Complicated insulin-dependent diabetes mellitus.

          -  Unstable cardiopulmonary disease requiring chronic medical therapy or associated with
             functional impairment.

          -  Presence of blood dyscrasias, including hemaglobinopathies and myelo- or
             lymphoproliferative disorder.

          -  Receipt of systemic glucocorticoids within 1 month of study enrollment, or any
             cytotoxic or immunosuppressive drugs within six months of study enrollment. Inhaled
             and topical steroids are allowed.

          -  A history of any demyelinating disease including Multiple Sclerosis and Guillain-Barré
             syndrome.

          -  Presence of an active neurological disorder.

          -  History of chronic alcohol consumption and/or drug abuse.

          -  Any significant disorder of coagulation that increases the risk of intramuscular
             injections or treatment with coumadin derivatives or heparin. Persons receiving
             prophylactic antiplatelet medications, e.g. low-dose aspirin, and without a
             clinically-apparent bleeding tendency are eligible.

          -  Receipt of an influenza vaccine within 6 months prior to study enrollment.

          -  Administration of any vaccines within 30 days prior to study enrollment or during the
             study period.

          -  Use of any investigational or non-registered product (drug or vaccine) other than the
             study vaccine(s) within 30 days preceding the vaccination or planned use during the
             study period.

          -  Administration of immunoglobulins and/or any blood products within the three months
             preceding the administration of the study vaccine or planned during the study.

          -  Any known or suspected allergy to any constituent of the vaccine.

          -  A history of severe adverse reaction to a previous influenza vaccination.

          -  If the subject is female, she must be of non-childbearing potential, or if she is of
             childbearing potential, she must practice adequate contraception for 30 days prior to
             vaccination, have a negative pregnancy test and continue such precautions for the
             duration of the study.

          -  Lactating/nursing female.

          -  Any condition which, in the opinion of the investigator, prevents the subject from
             participation in the study.