A Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus Sorafenib (BAY43-9006) in Chemonaive Patients With Stage IIIB-IV Non-Small Cell Lung Cancer (NSCLC)
Condition: Carcinoma, Non-Small-Cell Lung
MeSH terms: Carcinoma, Non-Small-Cell Lung
Intervention: Sorafenib + Paclitaxel + Carboplatin; Placebo + Paclitaxel + Carboplatin
Intervention description: Chemotherapy plus Multi Kinase Inhibitor: Sorafenib Group - Sorafenib (Nexavar, BAY43-9006), [400 mg, (2 tablets x 200 mg each) orally, twice daily] on Study Days 2-19 and paclitaxel (175 mg/m^2, intravenous (IV), over 2.5 to 4 hours) and carboplatin (area under the curve (AUC) =5, IV for 15 to 60 minutes) on Study Day 1. The cycle duration will be 21 days.; Chemotherapy + Placebo: Placebo Group - Placebo (2 tablets twice daily, orally) on Study Days 2-19 and paclitaxel (175 mg/m^2 IV, over 2.5 to 4 hours) and carboplatin (AUC=5 IV, for 15 to 60 minutes) on Study Day 1. The cycle duration will be 21 days
Intervention MeSH terms: Paclitaxel; Albumin-Bound Paclitaxel; Carboplatin; Sorafenib
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Enrollment: 91.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: NSCLC

Summary:

      The purpose of this study conducted in Asia-Pacific was to evaluate the efficacy and safety
      of Sorafenib in combination with paclitaxel and carboplatin versus placebo in combination
      with paclitaxel and carboplatin for chemonaive patients with unresectable stage IIIB (with
      effusion) or stage IV NSCLC. However, as indicated below, the study was terminated
      prematurely when the results from Study 11961 (NCT00300885), an earlier Phase 3 study of
      similar design in subjects with advanced NSCLC, showed an overall lack of efficacy and
      increased mortality in subjects with squamous subtype. The data available is presented as
      descriptive analyses, due to the limitations of implementing the statistical analysis plan.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Stage IIIB (with cytologically confirmed malignant pleural or pericardial effusion) or
             Stage IV histological or cytological confirmation of NSCLC (thoracentesis or
             pericardiocentesis is not necessary if a biopsy of the original tumor is available to
             confirm diagnosis of NSCLC)

          -  Patients must have measurable disease according to response evaluation criteria in
             solid tumors (RECIST) criteria

          -  Prior local radiotherapy is allowed if it is completed at least 3 weeks prior to the
             first dose of study drug, but the lesion which undergo RECIST assessment should not be
             in the field of the prior radiation

          -  Prior surgery is allowed if it is performed at least 4 weeks prior to the first dose
             of study drug

          -  18 years and above

          -  Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1

          -  Life expectancy of at least 12 weeks

          -  Adequate bone marrow, liver and renal function as assessed by the following laboratory
             requirements to be conducted within 7 days prior to start of first dose:

          -  Hemoglobin 9.0 g/dl

          -  Absolute neutrophil count (ANC) 1,500/mm3

          -  Platelet count 100,000/mm3

          -  Total bilirubin < 1.5 times the upper limit of normal

          -  alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x upper
             limit of normal (< 5 x upper limit of normal for patients with liver involvement)

          -  international normalized ratio (INR) < 1.5 and activated or adjusted partial
             thromboplastin time (APTT) within normal limits (1.2 times the lower limit of normal
             (LLN) to 1.2 times the upper limit of normal (ULN))

          -  Creatinine </= 1.5 times the upper limit of normal

          -  Ability to understand and the willingness to sign a written informed consent. A signed
             informed consent must be obtained prior to any study specific procedures

        Exclusion Criteria:

          -  Any prior systemic anticancer therapy including cytotoxic therapy, targeted agents,
             experimental therapy, adjuvant, or neo-adjuvant therapy for any current or prior
             diagnosis of NSCLC

          -  Cardiac disease: Congestive heart failure > class II New York Heart Association
             (NYHA). Patients must not have unstable angina (anginal symptoms at rest) or new-onset
             angina (began within the last 3 months) or myocardial infarction within the past 6
             months

          -  Known brain metastasis. Patients with neurological symptoms should undergo at Computed
             Tomography (CT) scan/Magnetic Resonance Imaging (MRI) of the brain to exclude brain
             metastasis

          -  Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

          -  Uncontrolled hypertension defined as systolic blood pressure > 150 mm Hg or diastolic
             pressure > 90 mm Hg, despite optimal medical management

          -  Known human immunodeficiency virus (HIV) infection

          -  Active clinically serious infections > Common Terminology Criteria for Adverse Events
             (CTCAE) Grade 2

          -  Thrombotic or embolic events such as cerebrovascular accident including transient
             ischemic attacks within the past 6 months

          -  Pulmonary hemorrhage/bleeding event > CTCAE Grade 2 within 4 weeks of first dose of
             study drug

          -  Any other hemorrhage/bleeding event > CTCAE Grade 3 within 4 weeks of first dose of
             study drug

          -  Serious, non-healing wound, ulcer, or bone fracture

          -  Evidence or history of bleeding diathesis or coagulopathy

          -  Major surgery, open biopsy or significant traumatic injury within 4 weeks of first
             dose of study drug

          -  Therapeutic anticoagulation with vitamin K antagonists such as warfarin, or with
             heparins or heparinoids. Low dose warfarin (1 mg daily, oral) is permitted if the INR
             remains < 1.5. Low-dose aspirin is permitted

          -  Known or suspected allergy to sorafenib or any agent given in the course of this trial

          -  Cancer other than NSCLC within 5 years prior to start of study treatment, EXCEPT
             cervical cancer in-situ, treated basal cell carcinoma, or superficial bladder tumors

          -  Concurrent cancer that is distinct in primary site or histology from NSCLC

          -  Substance abuse, medical, psychological or social conditions that may interfere with
             the patients participation in the study or evaluation of the study results

          -  Any condition that impairs patients ability to swallow whole pills

          -  Any malabsorption condition

          -  Women of childbearing potential must have a negative serum pregnancy test performed
             within 7 days prior to the start of treatment

          -  Women of childbearing potential and men must agree to use adequate contraception prior
             to study entry and for the duration of study participation, including the 30 days
             period after last study drug dosing. The investigator should advise the patient how to
             achieve an adequate contraception