A Long-term Safety Study of QMF149 in Japanese Participants With Asthma
Condition: Asthma
MeSH terms: Asthma
Intervention: QMF149
Intervention description: QMF149 150/320 μg once daily, delivered as powder in hard capsules via Concept1 inhaler
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 51.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: QVM149,; Asthma,; Japanese,; Allergic asthma,; Allergy triggered asthma,; Reactive asthma,; Asthma attack,; Difficulty breathing

Summary:

      The purpose of this study was to provide long term safety data of QMF149 in Japanese
      participants with inadequately controlled asthma for the registration of QMF149 in Japan.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Written informed consent must be obtained before any assessment is performed.

          -  Male and female adult patient ≥ 18 years old.

          -  Patients with a diagnosis of persistent asthma for a period of at least 1 year prior
             to Visit 1.

          -  Patients who have used medium or high dose inhaled corticosteroids (ICS) plus at least
             1 controller for asthma for at least 3 months and at stable dose and regimen for at
             least 4 weeks prior to Visit 1.

          -  Patients must have Asthma Control Questionnaire-7 (ACQ-7) score ≥ 1.5 at Visits 2 and
             qualify for treatment with high dose ICS/long-acting β2 agonist (LABA).

          -  Pre-bronchodilator Forced Expiratory Volume in 1 second (FEV1) of ≥ 50% and ≤ 85% of
             the predicted normal value for the patient after withholding bronchodilators at Visit
             2.

          -  Repeating is allowed once only. Repeating of percentage predicted FEV1 should be done
             in an ad-hoc visit to be scheduled on a date that would provide sufficient time to
             receive confirmation from the spirometry data central reviewer of the validity of the
             assessment before Visit 99.

          -  Patients must demonstrate reversibility defined as an increase in FEV1 of ≥ 12% and
             200 mL within 15 to 30 minutes after administration of 400 µg of salbutamol at Visit
             2. Spacer devices are permitted during reversibility testing only. The Investigator or
             delegate may decide whether or not to use a spacer for the reversibility testing.

               -  If reversibility is not proven at Visit 2, patients may be permitted to enter the
                  study with historical evidence of reversibility that was performed within 5 years
                  prior to Visit 1.

               -  Alternatively, patients may be permitted to enter the study with a historical
                  positive bronchoprovocation test (defined as a provoked fall in FEV1 of 20% by
                  bronchoconstriction agent e.g., methacholine, histamine) or equivalent test
                  (e.g., astography) that was performed within 5 years prior to Visit 1.

               -  Where patient is assessed as eligible based on historical evidence, a copy of the
                  original printed report must be available as source documentation.

               -  If reversibility is not proven at Visit 2 and historical data is not available,
                  reversibility should be repeated once in an ad-hoc visit scheduled as close as
                  possible from the first attempt (but not on the same day).

               -  If reversibility is not demonstrated at Visit 2 (or after repeated assessment at
                  ad-hoc visit) and historical evidence of
                  reversibility/bronchoprovocation/astography is not available, patients must be
                  screen failed.

        Exclusion Criteria:

          -  Patients who have had an asthma attack/exacerbation requiring systemic steroids or
             hospitalization or emergency room visit within 6 weeks of Visit 1.

          -  Patients who have ever required intubation for a severe asthma attack/exacerbation.

          -  Patients who have a clinical condition which is likely to be worsened by ICS
             administration (e.g. glaucoma, cataract and fragility fractures) who are according to
             investigator's medical judgment at risk participating in the study.

          -  Patients who have had a respiratory tract infection or asthma worsening as determined
             by investigator within 4 weeks prior to Visit 1 or between Visit 1 and Visit 99.
             Patients may be re-screened 4 weeks after recovery from their respiratory tract
             infection or asthma worsening.

          -  Patients with a history of chronic lung diseases other than asthma, including (but not
             limited to) chronic obstructive pulmonary disease, sarcoidosis, interstitial lung
             disease, cystic fibrosis, clinically significant bronchiectasis and active
             tuberculosis.

          -  Patients with severe narcolepsy and/or insomnia.

          -  Pregnant or nursing (lactating) women.

          -  Women of child-bearing potential unless they are using highly effective methods of
             contraception during dosing and for 30 days after stopping of investigational
             medication.