Immunogenicity and Safety of Pediatric Vaccines When Administered With Menactra® in Healthy Toddlers
Condition: Meningococcal Meningitis; Measles; Mumps; Rubella; Varicella
MeSH terms: Measles; Chickenpox; Herpes Zoster; Rubella; Meningitis, Meningococcal; Meningitis
Intervention: Meningococcal Polysaccharide Diphtheria Conjugate Vaccine; Meningococcal Polysaccharide Diphtheria Conjugate Vaccine; Meningococcal Polysaccharide Diphtheria Conjugate Vaccine; Measles, Mumps, Rubella and Varicella
Intervention description: 0.5 mL dose, intramuscular (IM); 0.5 mL dose, IM; 0.5 Ml dose, IM; 0.5 mL dose, SC
Intervention MeSH terms: Vaccines
Phase: Phase 3
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Investigator)
Enrollment: 1664.0
Sex: All
Minimum age: 9 Months
Maximum age: 12 Months
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Menactra vaccine; Meningococcal meningitis; Measles; Mumps; Rubella; Varicella vaccines; Haemophilus influenzae type b; Pneumococcal conjugate vaccine

Summary:

      This is a modified single-blind, randomized, parallel-group, comparative, multicenter study
      to test Menactra vaccine in toddlers.

      Primary Objectives:

        -  To evaluate the antibody responses induced by Measles, Mumps, Rubella, and Varicella
           (MMRV) vaccine when administered alone or concomitantly with Menactra vaccine.

        -  To evaluate the antibody responses induced by Pneumococcal Conjugated Vaccine (PCV) when
           administered alone or concomitantly with Menactra vaccine.

      Observational Objectives:

      Safety - To describe the safety profile throughout the course of the study from Day 0 up to 6
      months after the last study vaccination[s]) in subjects in the study groups.

      Immunogenicity:

      - To describe the antibody responses to meningococcal serogroups A, C, Y, and W-135, 30 days
      after the first and second Menactra vaccine administration in a subset of subjects in the
      first study group.
    

Eligibility criteria:

        Inclusion Criteria :

          -  Healthy, as determined by medical history and physical examination

          -  Aged 9 months (249 to 291 days) for Groups 1, 2, and 3 or aged 12 months (365 to 386
             days) for Group 4 at the time of enrollment

          -  The parent or legal guardian has signed and dated the Institutional Review Board
             (IRB)-approved informed consent form.

        Exclusion Criteria :

          -  Serious acute or chronic disease (e.g., cardiac, renal, metabolic, rheumatologic,
             psychiatric, hematologic, autoimmune disorders, diabetes, atopic conditions,
             congenital defects, convulsions, encephalopathy, blood dyscrasias, leukemia, lymphomas
             of any type, or other malignant neoplasms affecting the bone marrow or lymphatic
             system, acute untreated tuberculosis) that could interfere with trial conduct or
             completion

          -  Known or suspected impairment of immunologic function

          -  Acute medical illness within the last 72 hours or a temperature ≥ 100.4ºF (≥38.0ºC) at
             the time of enrollment.

          -  History of documented invasive meningococcal disease or previous meningococcal
             vaccination.

          -  Known human immunodeficiency virus (HIV), hepatitis B, or hepatitis C seropositivity
             as reported by the parent or legal guardian

          -  Received either immune globulin or other blood products within the last 3 months, or
             received injected or oral corticosteroids, or other immunomodulator therapy within 6
             weeks of the study vaccines. Individuals on a tapering dose schedule of oral steroids
             lasting < 7 days and individuals (e.g., asthmatics) on a short schedule of oral
             steroids lasting 3 to 4 days may be included in the trial as long as they have not
             received more than one course within the last two weeks prior to enrollment. Topical
             steroids are not included in this exclusion criterion.

          -  Anticipated to receive oral or injected antibiotic therapy within the 72 hours prior
             to any blood draw. Topical antibiotics and antibiotic drops are not included in this
             exclusion criterion.

          -  Suspected or known hypersensitivity to any of the vaccine components or history of a
             life-threatening reaction to the study vaccines or a vaccine containing the same
             substances. For ProQuad vaccine recipients, this includes a hypersensitivity to
             gelatin or a history of anaphylactic reactions to neomycin.

          -  Thrombocytopenia or a bleeding disorder contraindicating intramuscular (IM)
             vaccination.

          -  Parent or legal guardian unable or unwilling to comply with the study procedures

          -  Participation in another interventional clinical trial in the 30 days preceding
             enrollment or planned participation in another clinical trial involving the
             investigation of a drug, vaccine, medical procedure, or medical device during the
             subject's trial period.

          -  Diagnosed with any condition, which, in the opinion of the investigator, would pose a
             health risk to the subject or interfere with the evaluation of the vaccine

          -  Received any vaccine in the 30-day period prior to receipt of the study vaccines, or
             scheduled to receive any vaccination other than influenza vaccination and
             hyposensitization therapy in the 30-day period after receipt of the study vaccines.
             Hyposensitization therapy and influenza vaccination may be received up to two weeks
             before or two weeks after receiving the study vaccines. Subjects should not have
             received their fourth dose of Pneumococcal conjugate vaccine (PCV) or Haemophilus
             influenzae type b (Hib) vaccine or their first dose of Measles, mumps, rubella,
             varicella (MMRV) vaccine before enrollment or been scheduled to receive these vaccines
             outside of the study-specified visits.

          -  Personal or family history of Guillain-Barré Syndrome (GBS)

          -  History of seizures, including febrile seizures, or any other neurologic disorder

          -  Known hypersensitivity to dry natural rubber latex.