Time to Eugonadal Range, Time to Steady State and Drying Time
Condition: Male Hypogonadism
MeSH terms: Hypogonadism
Intervention: testosterone gel 2%
Intervention description: 40 mg testosterone gel 2%
Intervention MeSH terms: Testosterone
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 34.0
Sex: Male
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: No
Keywords: testosterone deficiency; hypogonadism

Summary:

      This is a multicenter, open-label, single arm trial to evaluate the time to eugonadal
      testosterone range after initial testosterone gel 2% application, time to steady state after
      after initiation of testosterone gel 2%, and drying time after application of testosterone
      gel 2%.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Men aged 18 to 65 years.

          2. Have a diagnosis of primary or secondary hypogonadism with a:

               -  Single morning serum total testosterone concentration <250 ng/dL or

               -  Two (2) consecutive morning serum total testosterone concentrations <300 ng/dL
                  (determined at least 1 week apart during a 3 week screening period) Total serum
                  testosterone sampling must occur between 7 AM and 11 AM at screening

          3. Have a body mass index (BMI) ≥22 kg/m2 and ≤35 kg/m2.

          4. Have a hematocrit level ≤50% at screening

          5. Use of reliable contraception for subjects who have sexual partners of childbearing
             potential (women not of childbearing potential are defined as postmenopausal, ie,
             amenorrhea ≥1 year or permanently sterile). Reliable methods of contraception are:

               -  Barrier type devices (eg, condom, female condom, diaphragm, contraceptive sponge)
                  only in combination with a spermicide.

               -  Intra-uterine devices.

               -  Oral, injectable, transdermal or implantable hormonal contraceptives.

          6. Is able to understand and give written informed consent

        Exclusion Criteria:

          1. Severe concomitant illness, which in the opinion of the Investigator, may put the
             subject at risk when participating in the trial or may influence the results of the
             trial or affect the subjects' ability to take part in the trial.

          2. Acute or chronic renal impairment [(Cr ≥ 1.5x ULN (upper limit of normal)].

          3. Acute or chronic hepatic impairment will be excluded.

          4. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels >2.5 × ULN
             (upper limit of normal).

          5. Clinically significant, abnormal, baseline laboratory result(s), which in the opinion
             of the Investigator affect(s) the subject's suitability for the trial.

          6. History of, or any existing, clinically significant cardiac disease (New York Heart
             Association [NYHA] Class III and IV).

          7. Clinically significant electrocardiogram (ECG) abnormalities such as QTcB or QTcF ≥450
             msec; or QTc ≥480 msec in subjects with bundle branch block.

          8. Prostate specific antigen (PSA) level >4 ng/mL.

          9. An abnormality on digital rectal examination deemed to be suspicious or worrisome for
             cancer, such as a nodule or asymmetric induration.

         10. Severe symptomatic benign prostatic hyperplasia or International Prostate Symptom
             Score (IPSS) >19 (at screening).

         11. Sleep apnea which is untreated, or subjects with sleep apnea which is treated
             (including c-PAP treatment) but in the opinion of the investigator has been clinically
             unstable during the 3 months prior to screening.

         12. Current eczema, psoriasis, sunburn, or any other clinically significant skin condition
             at the application site.

         13. Current abrasions at site of application.

         14. Malignancy (or suspected malignancy) of any type except a basal cell carcinoma.
             Subjects with a history of malignancy must have a disease free status ≥5 years prior
             to starting study treatment. Subjects who have had prostate or breast cancer are not
             permitted to participate in the study.

         15. Known to be sensitive and/or has had an adverse skin reaction to testosterone hormone
             replacement therapy or topical products containing alcohol.

         16. Actively or potentially trying to start a family or requiring fertility treatment or
             with a spouse/partner who is pregnant.

         17. Participated in any experimental drug or device study within 30 days prior to starting
             study treatment.

         18. History of alcohol or substance abuse within the last year.

         19. Taking opioids for any reason within 3 days of screening

         20. Receiving the following medications:

               -  Androgen treatments.

               -  Androgen antagonists.

               -  Application of any lotions, ointments, or steroids to the application site.

               -  5alpha-reductase inhibitors (eg, finasteride, dutasteride).

         21. Any subjects receiving testosterone hormone replacement treatments must abide by the
             indicated washout period prior to screening total serum testosterone measurement