EXTEND (Eltrombopag Extended Dosing Study)
Condition: Purpura, Thrombocytopaenic, Idiopathic
MeSH terms: Purpura; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic
Intervention: eltrombopag olamine (SB-497115-GR)
Intervention description: Eltrombopag with starting dose of 50mg daily, max dose of 75mg daily and min dose of 25mg daily or less frequently. Modifications were given to maintain platelet count in range of 50 to 200 Gi/L.
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 302.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: eltrombopag olamine; SB-497115-GR; idiopathic thrombocytopenic purpura; thrombocytopenia; ITP; platelets

Summary:

      An open-label, dose-adjustment, extension study to evaluate the safety and efficacy of
      eltrombopag for the treatment of subjects with idiopathic thrombocytopenic purpura (ITP) who
      have previously been enrolled in an eltrombopag trial. This study will allow adjustment of
      the eltrombopag dose to achieve an individualized dose and schedule for each subject. In
      addition, the ability to reduce the dose of concomitant ITP medications in the presence of
      eltrombopag, while maintaining platelet counts = 50,000/μL will be investigated.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Subject has signed and dated a written informed consent.

          -  Adults (≥18 years) diagnosed with ITP according to the American Society for
             Hematology/British Committee for Standards in Haematology (ASH/BCSH) guidelines
             [George, 1996; BCSH, 2003]. In addition, a peripheral blood smear should support the
             diagnosis of ITP with no evidence of other disease causative of thrombocytopenia
             (e.g., pseudo thrombocytopenia, myelofibrosis). The physical examination should not
             suggest any disease which may cause thrombocytopenia other than ITP.

          -  Prior completion of treatment and follow up periods in an ITP study of eltrombopag
             (e.g., TRA100773 or TRA102537/RAISE or TRA108057/REPEAT).

          -  Subjects previously enrolled in Study TRA100773 must have completed the prescribed
             follow-up ophthalmic assessment at 6 months.

          -  Subjects previously enrolled in TRA102537/RAISE or other studies that may lead into
             EXTEND (e.g., TRA108057/REPEAT) must have completed the treatment and follow-up
             periods as defined in that protocol.

          -  Subject experienced no eltrombopag-related toxicity or other drug intolerance on prior
             eltrombopag study (e.g., TRA100773 or TRA102537/RAISE or TRA108057/REPEAT) even if
             resolved; subjects discontinued from previous study due to toxicity will not be
             eligible unless they received placebo.

          -  Subject has no intercurrent medical event, including thrombosis.

          -  Subjects must have either initially responded (platelet count > 100,000/mL) to a
             previous ITP therapy or have had a bone marrow examination consistent with ITP within
             3 years to rule out myelodysplastic syndromes or other causes of thrombocytopenia

          -  Previous therapy for ITP with immunoglobulins (IVIg and anti-D) must have been
             completed at least 1 week prior to first dose of study medication and the platelet
             count must show a clear downward trend after the last treatment with immunoglobulins.
             Previous treatment for ITP with splenectomy, rituximab and cyclophosphamide must have
             been completed at least 4 weeks prior to randomization, or clearly be ineffective.

          -  Subjects treated with concomitant ITP medication (e.g. corticosteroids or
             azathioprine) must be receiving a dose that has been stable for at least 4 weeks prior
             to randomization. Subjects treated with cyclosporine A, mycophenolate mofetil or
             danazol must be receiving a dose that has been stable for at least 3 months prior to
             the first dose of study medication.

          -  Prothrombin time (PT/INR) and activated partial thromboplastin time (aPTT) must be
             within 80 to 120% of the normal range with no history of hypercoagulable state.

          -  A complete blood count (CBC), within the reference range (including WBC differential
             not indicative of a disorder other than ITP), with the following exceptions:

          -  Hemoglobin: Subjects with hemoglobin levels between 10.0 g/dL and the lower limit of
             normal are eligible for inclusion, if anemia is clearly attributable to ITP (excessive
             blood loss).

          -  ANC≥1500/mL (1.5 x 10^9/L) is required for inclusion (elevated WBC/ANC due to steroid
             treatment is acceptable).

          -  The following clinical chemistries MUST NOT exceed the upper limit of normal (ULN)
             reference range by more than 20%: creatinine, ALT, AST, total bilirubin, and alkaline
             phosphatase. In addition, total albumin must not be below the lower limit of normal
             (LLN) by more than 10%.

          -  Subject is practicing an acceptable method of contraception (documented in chart).
             Female subjects (or female partners of male subjects) must either be of
             non-childbearing potential (hysterectomy, bilateral oophorectomy, bilateral tubal
             ligation or post-menopausal > 1 year), or of childbearing potential and use one of the
             following highly effective methods of contraception (i.e., Pearl Index <1.0%) from two
             weeks prior to administration of study medication, throughout the study, and 28 days
             after completion or premature discontinuation from the study:

          -  Complete abstinence from intercourse;

          -  Intrauterine device (IUD);

          -  Two forms of barrier contraception (diaphragm plus spermicide, and for males condom
             plus spermicide);

          -  Male partner is sterile prior to entry into the study and is the only partner of the
             female;

          -  Systemic contraceptives (combined or progesterone only).

          -  Subject is able to understand and comply with protocol requirements and instructions.

        Exclusion Criteria:

        A subject will not be eligible for inclusion in this study if any of the following criteria
        apply:

          -  Any clinically relevant abnormality, other than ITP, identified on the screening
             examination, or any other medical condition or circumstance, which in the opinion of
             the investigator makes the subject unsuitable for participation in the study or
             suggests another diagnosis.

          -  Concurrent malignant disease and/or history of cancer treatment with cytotoxic
             chemotherapy and/or radiotherapy.

          -  Any prior history of arterial or venous thrombosis (stroke, transient ischemic attack,
             myocardial infarction, deep vein thrombosis or pulmonary embolism), AND≥two of the
             following risk factors: hormone replacement therapy, systemic contraception
             (containing estrogen), smoking, diabetes, hypercholesterolemia, medication for
             hypertension, cancer, hereditary thrombophilic disorders (e.g., Factor V Leiden, ATIII
             deficiency, etc), or any other family history of arterial or venous thrombosis

          -  Pre-existing cardiovascular disease (including congestive heart failure, New York
             Heart Association [NYHA] Grade III/IV), or arrhythmia known to increase the risk of
             thromboembolic events (e.g. atrial fibrillation), or subjects with a QTc >450 msec.

          -  Female subjects who are nursing or pregnant (positive serum or urine b-human chorionic
             gonadotrophin (b-hCG) pregnancy test) at screening or pre-dose on Day 1.

          -  History of alcohol/drug abuse.

          -  Treatment with an investigational drug within 30 days or five half-lives (whichever is
             longer) preceding the first dose of study medication.

          -  Subject treated with drugs that affect platelet function (including but not limited to
             aspirin, clopidogrel and/or NSAIDs) or anti-coagulants for > 3 consecutive days within
             2 weeks of the study start and until the end of the study.

          -  History of platelet agglutination abnormality that prevents reliable measurement of
             platelet counts.

          -  All subjects with secondary immune thrombocytopenia, including those with laboratory
             or clinical evidence of HIV infection, antiphospholipid antibody syndrome, chronic
             hepatitis B infection, hepatitis C virus infection, or any evidence for active
             hepatitis at the time of subject screening. If a potential subject has no clinical
             history that would support HIV infection or hepatitis infection, no further laboratory
             screening is necessary; however, standard medical practice would suggest further
             evaluation of patients who have risk factors for these infections.

          -  A subject is planning to have cataract surgery.

          -  In France, a subject is neither affiliated with nor a beneficiary of a social security
             category.

        Other Eligibility Criteria Considerations:

        To assess any potential impact on subject eligibility with regard to safety, the
        investigator must refer to the following document(s) for detailed information regarding
        warnings, precautions, contraindications, adverse events, and other significant data
        pertaining to the investigational product(s) being used in this study: CIB, SPM.