Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery
Condition: Cystoscopes; Baxter Anaesthesia Brand of Desflurane; Sevoflurane
Intervention: Desflurane; Sevoflurane
Intervention description: 5.4 to 7.4% desflurane; 1.4 to 2.5% Sevoflurane
Intervention MeSH terms: Sevoflurane; Desflurane
Phase: Phase 3
Study type: Interventional
Primary purpose: Health Services Research
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Enrollment: 75.0
Sex: All
Minimum age: 50 Years
Maximum age: 75 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: desflurane; sevoflurane

Summary:

      This is a single-center, prospective, randomized, double-blind, double-arm trial including 68
      subjects scheduled to undergo urological cystoscope surgeries under general anesthesia (GA)
      with intubation through a laryngeal mask airway (LMA) at The Ohio State University Medical
      Center (OSUMC). Double blinding will be based on both the subject and the research staff
      being unaware of which trial arm the subject is randomized into. Eligible subjects that
      provide voluntary and written informed consent will be included in this study.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Male or female, 50 to 75 years of age.

          2. Subjects with an American Society of Anesthesiologist (ASA) physical status of I to
             III.

          3. Subjects able to provide written informed consent to participate in the study.

          4. Female subjects who have a negative urine or serum pregnancy test, who have been
             surgically sterilized, or are postmenopausal.

          5. Subjects scheduled for urological cystoscopic surgery under general anesthesia with
             LMA intubation.

        Exclusion Criteria:

          1. Subjects who are prisoners.

          2. Subjects who have limited decision-making capacity or lack the ability to consent.

          3. Subjects with a history of alcohol or drug abuse within the last year.

          4. Subjects with a history of an allergic reaction, intolerance, or contraindications to
             any of the study medications.

          5. Females who are pregnant or are breastfeeding.

          6. Subjects with BMI greater than 35.

          7. Subjects with a history of hiatal hernia or gastroesophageal reflux disease (GERD).

          8. Subjects with a history of pharyngeal pathology.

          9. Subjects who have participated in or are currently participating in a clinical trial
             of an investigational drug within 30 days prior to surgery.

         10. Subjects with a fixed decreased pulmonary compliance, such as patients with pulmonary
             fibrosis.

         11. Subjects with multiple or massive injuries, acute abdominal and/or thoracic injuries.

         12. Subjects with any condition associated with delayed gastric emptying.

         13. Subjects who are profoundly unconscious and who may not resist LMA insertion or have a
             contraindication for the use of LMA intubation.

         14. Subjects with any condition that in the opinion of the investigator would render the
             subject ineligible for participation in the study, such as unstable or severe
             cardiovascular, pulmonary, renal, hepatic, metabolic, or endocrine disease or
             neuromuscular disorder.

         15. Subjects with a history of malignant hyperthermia.