An Efficacy and Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting
Condition: Chemotherapy-Induced Nausea and Vomiting
MeSH terms: Nausea; Vomiting
Intervention: Netupitant and Palonosetron; Palonosetron; Dexamethasone
Intervention MeSH terms: Dexamethasone; Palonosetron
Phase: Phase 3
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 1455.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      NETU-08-18 is a two-arm clinical study assessing efficacy and safety of a single oral dose of
      netupitant and palonosetron, two antiemetic drugs, versus oral palonosetron, both given with
      oral dexamethasone. The objective of the study is to demonstrate that netupitant and
      palonosetron are more effective than palonosetron alone, to prevent nausea and vomiting
      induced by moderately emetogenic cancer chemotherapy after administration of repeated cycles
      of chemotherapy.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Naïve to cytotoxic chemotherapy. Previous biological or hormonal therapy will be
             permitted.

          -  Scheduled to receive first course of an anthracycline and cyclophosphamide containing
             moderately emetogenic chemotherapy (MEC) regimen for the treatment of a solid
             malignant tumor: cyclophosphamide I.V. (500 to 1500 mg/m2) and I.V. doxorubicin (more
             or equal to 40 mg/m2) or cyclophosphamide I.V. (500 to 1500 mg/m2) and I.V. epirubicin
             (more or equal to 60 mg/m2).

          -  If scheduled to receive chemotherapy agents of minimal to low emetogenic potential
             they could be given on any day.

          -  Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2.

          -  Female patients of either non-childbearing potential or child-bearing potential with a
             commitment to use contraceptive methods throughout the clinical trial

          -  Hematologic and metabolic status adequate for receiving a moderately emetogenic
             regimen based on laboratory criteria (Total Neutrophils,Platelets, Bilirubin, Liver
             enzymes, Serum Creatinine or Creatinine Clearance)

        The following inclusion criteria must be checked prior inclusion at each cycle of the
        Multiple-Cycle Extension:

          -  Participation in the study during the next cycle of chemotherapy is considered
             appropriate by the investigator Satisfactory study compliance in the preceding cycle
             of chemotherapy and related study procedures.

          -  Scheduled to receive the same chemotherapy regimen as cycle 1

          -  Adequate hematologic and metabolic status as defined for cycle 1

        Exclusion Criteria:

          -  If female, pregnant or lactating.

          -  Current use of illicit drugs or current evidence of alcohol abuse.

          -  Scheduled to receive any highly emetogenic chemotherapy (HEC) from Day 1 to Day 5 or
             moderately emetogenic chemotherapy (MEC) from Day 2 to Day 5 following the allowed MEC
             regimen.

          -  Received or is scheduled to receive radiation therapy to the abdomen or the pelvis
             within 1 week prior to Day 1 or between Days 1 to 5 in cycle 1.

          -  Any vomiting, retching, or mild nausea within 24 hours prior to Day 1.

          -  Symptomatic primary or metastatic central nervous system (CNS) malignancy.

          -  Active peptic ulcer disease, gastrointestinal obstruction, increased intracranial
             pressure, hypercalcemia, an active infection or any uncontrolled medical condition
             (other than malignancy) that, in the opinion of the investigator, may confound the
             results of the study, represent another potential etiology for emesis and nausea
             (other than chemotherapy-induced nausea and vomiting, CINV) or pose unwarranted risks
             in administering the study drugs to the patient.

          -  Known hypersensitivity or contraindication to 5-HT3 receptor antagonists or
             dexamethasone.

          -  Previously received a neurokin-1 (NK1) receptor antagonist

          -  Participation in a clinical trial involving oral netupitant administered in
             combination with palonosetron.

          -  Any investigational drugs taken within 4 weeks prior to Day 1 of cycle 1, and/or is
             scheduled to receive any investigational drug during the study.

          -  Systemic corticosteroid therapy at any dose within 72 hours prior to Day 1 of cycle 1.

          -  Scheduled to receive bone marrow transplantation and/or stem cell rescue therapy.

          -  Any medication with known or potential antiemetic activity within 24 hours prior to
             Day 1 of cycle 1

          -  Scheduled to receive any strong or moderate inhibitor of cytocrome P450 3A4 (CYP3A4)
             or its intake within 1 week prior to Day 1.

          -  Scheduled to receive any of the following CYP3A4 substrates: terfenadine, cisapride,
             astemizole, pimozide.

          -  Scheduled to receive any CYP3A4 inducer or its intake within 4 weeks prior to Day 1.

          -  History or predisposition to cardiac conduction abnormalities, except for incomplete
             right bundle branch block.

          -  History of risk factors for Torsade de Point (heart failure, hypokalemia, family
             history of Long QT Syndrome).

          -  Severe cardiovascular diseases, including myocardial infarction within 3 months prior
             to Day 1, unstable angina pectoris, significant valvular or pericardial disease,
             history of ventricular tachycardia, symptomatic Congestive Heart Failure (CHF) New
             York Heart Association (NYHA) class III-IV, and severe uncontrolled arterial
             hypertension.

          -  Any illness or condition that, in the opinion of the investigator, may confound the
             results of the study or pose unwarranted risks in administering the investigational
             product to the patient.

          -  Concurrent medical condition that would preclude administration of dexamethasone such
             as systemic fungal infection or uncontrolled diabetes.

        The following exclusion criteria must be checked prior inclusion at each cycle of the
        Multiple-Cycle Extension:

          -  If female, pregnant or lactating

          -  Active infection or uncontrolled disease except for malignancy.

          -  Started any of the restricted medications.

          -  Any vomiting, retching, or mild nausea within 24 hours prior to Day 1.