A Study in the Treatment of Children and Adolescents With Major Depressive Disorder
Condition: Major Depressive Disorder
MeSH terms: Depressive Disorder; Depression; Depressive Disorder, Major
Intervention: duloxetine; Placebo; fluoxetine
Intervention description: 30-120 mg, PO, QD, for up to 38 weeks; Capsules identical in appearance, color, taste and smell to study drug, orally (PO), once daily (QD). Dose: placebo, 6 capsules, QD for 10 weeks; 10-40 milligram (mg), PO, QD, for up to 38 weeks
Intervention MeSH terms: Duloxetine Hydrochloride; Fluoxetine
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 337.0
Sex: All
Minimum age: 7 Years
Maximum age: 17 Years
Healthy volunteers: No

Summary:

      The purpose of this study is to assess whether duloxetine is superior to placebo in the
      treatment of children and adolescents with major depressive disorder (MDD)
    

Eligibility criteria:

        Inclusion Criteria:

          -  Outpatient, diagnosed with major depressive disorder (MDD) as defined by the
             Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision
             (DSM-IV-TR) and supported by the Mini International Neuropsychiatric Interview for
             children and adolescents (MINI-KID).

          -  Diagnosis of moderate or greater severity of MDD as determined by Children's
             Depression Rating Scale - Revised (CDRS-R) with a total score greater than or equal to
             40 at screen, and randomization and a Clinical Global Impression of Severity
             (CGI-Severity) rating of greater than or equal to 4 at screen, and randomization.

          -  Female patients must test negative for pregnancy during screening.

          -  Judged to be reliable by the investigator to keep all appointments for clinical
             visits, tests, and procedures required by the protocol.

          -  Has a degree of understanding such that they can communicate intelligently with the
             investigator and study coordinator.

          -  Capable of swallowing study drug whole. It is anticipated the patients will need to
             swallow up to 6 capsules per day.

          -  Patients must have venous access sufficient to allow blood sampling and are compliant
             with blood draws as per the protocol.

        Exclusion Criteria:

          -  Children of site personnel directly affiliated with this study and/or their immediate
             families.

          -  Children of Lilly employees or employees of the designated clinical research
             organization (CRO) assisting with the conduct of the study.

          -  Have received treatment within the last 30 days with a drug that has not received
             regulatory approval for any indication at the time of study entry.

          -  Have a current or previous diagnosis of bipolar disorder, psychotic depression,
             schizophrenia or other psychotic disorder, anorexia, bulimia, obsessive compulsive
             disorder, or pervasive development disorder, as judged by the investigator.

          -  Have a history of DSM-IV-TR-defined substance abuse or dependence within the past
             year, excluding caffeine and nicotine.

          -  Have a current primary DSM-IV-TR Axis I disorder other than MDD or a current secondary
             DSM-IV-TR Axis I disorder that requires any pharmacologic treatment

          -  Have 1 or more first-degree relatives with diagnosed bipolar I disorder.

          -  Have a significant suicide attempt within 1 year of screening or are currently at risk
             of suicide in the opinion of the investigator.

          -  Have a weight less than 20 kilogram (kg) at screening.

          -  Have a lack of response to 2 or more adequate treatment trials of antidepressants at a
             clinically appropriate dose for a minimum of 4 weeks for the same MDD episode.

          -  Have initiated, stopped, or changed the type or intensity of psychotherapy within 6
             weeks prior to screening.

          -  Have a history of seizure disorder (other than febrile seizures).

          -  Have a history of electroconvulsive therapy within 1 year of screening.

          -  Have had treatment with a monoamine oxidase inhibitor (MAOI) within 14 days or
             fluoxetine within 30 days of randomization; or the potential need to use an MAOI
             during the study or within 5 weeks of discontinuation of study drug.

          -  Have previously enrolled, completed, or withdrawn from this study or any other study
             investigating duloxetine or fluoxetine.

          -  Have a positive urine drug screen for any substances of abuse or excluded medication.

          -  Are taking any excluded medications that cannot be discontinued by screening.

          -  Have known hypersensitivity to duloxetine, fluoxetine, or their inactive ingredients;
             or have frequent or severe allergic reactions to multiple medications.

          -  Have uncontrolled narrow-angle glaucoma.

          -  Have acute liver injury or severe cirrhosis.

          -  Have a serious or unstable medical illness, psychological condition, or clinically
             significant laboratory or electrocardiogram (ECG) result that, in the opinion of the
             investigator, would compromise participation in the study or be likely to lead to
             hospitalization.

          -  Have abnormal thyroid-stimulating hormone concentration.

          -  Have initiated or discontinued hormone therapy within the previous 3 months.

          -  Female patients who are either pregnant, nursing or have recently given birth.

          -  Need to use thioridazine during the study or within 5 weeks after discontinuation of
             study drug or need to use pimozide during the study.