An Efficiency of a Moisturizer Containing Licochalcone A, L-carnitine and 1,2-decanediol With Adapalene Gel in Acne
Condition: Acne
MeSH terms: Acne Vulgaris
Intervention: Adapalene gel with Eucerin; Adapalene gel; Adapalene gel with placebo moisturizer
Intervention description: Eucerin: 2 fingertip unit to cover all over the face twice a day. Adapalene gel: 2 fingertip unit to cover all over the face before going to bed; Adapalene gel: 2 fingertip unit to cover all over the face before going to bed; Placebo: 2 fingertip unit to cover all over the face twice a day. Adapalene gel: 2 fingertip unit to cover all over the face before going to bed
Intervention MeSH terms: Adapalene
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Enrollment: 120.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Acne; Moisturizer; Efficacy; Irritation

Summary:

      Acne is an inflammation of sebaceous glands and follicles. Applying topical treatments such
      as adapalene gel may cause irritant adverse effects. Hence, using a moisturizer is another
      way to protect or relieve this undesirable event. Moisturizers that have anti-inflammatory
      property could reduce irritant effects, emergent from using topical treatment and also reduce
      severity of acne.

      Research teams chose an adapalene gel to act as topical treatment for curing acne. It has
      anti-inflammatory and comedolytic effects and has fewer side effects than other groups of
      topical retinoic acids. However, peeling skin, redness skin, tingling sensation or itching
      sensation may occur if they are continually used for a long period. Thus, for the purpose of
      studying the efficacy of moisturizer containing licochalcone A, L-carnitine and
      1,2-decanediol in reducing irritant effect of using adapalene gel (Licochalcone A has
      anti-inflammatory effect, L-carnitine decrease sebum production and 1,2-decanediol has
      anti-bacterial effect).
    

Eligibility criteria:

        Inclusion Criteria:

          1. Age 18 years old or above

          2. Participants have to control the birth for example, condom method, intrauterine device
             method before participate in the research at least 1 month until 6 months after
             research finish.

          3. being diagnosed acne vulgaris by dermatologist in mild to moderate degree based on
             Investigators' Global Assessment scale of FDA

        Exclusion Criteria:

          1. Use oral or injected antibiotics or other oral medicine treating acne for example,
             isotretinoin, oral contraceptives, or spironolactone group during 4 weeks before
             participate this research

          2. Have other active skin diseases at face during 2 weeks before participate the research

          3. Allergic to adapalene gel and moisturizer

          4. Have severe or uncontrolled underlying diseases

          5. Getting pregnant or during breast feeding

          6. Other types of acne(not acne vulgaris)