A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL
Condition: Chronic Lymphocytic Leukemia
MeSH terms: Leukemia; Leukemia, Lymphoid; Leukemia, Lymphocytic, Chronic, B-Cell
Intervention: Acalabrutinib (ACP-196); Rituximab; Idelalisib; Bendamustine
Intervention description: Acalabrutinib monotherapy; Rituximab in combination with idelalisib or bendamustine; Idelalisib in combination with rituximab; Bendamustine in combination with rituximab
Intervention MeSH terms: Rituximab; Bendamustine Hydrochloride; Acalabrutinib; Idelalisib
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Enrollment: 310.0
Sex: All
Healthy volunteers: No
Keywords: CLL; BTK; Bruton Tyrosine Kinase; acalabrutinib; ACP-196

Summary:

      This study is designed to evaluate the efficacy of acalabrutinib compared with rituximab in
      combination with idelalisib or bendamustine in previously treated subjects with chronic
      lymphocytic leukemia (CLL).
    

Eligibility criteria:

        Inclusion Criteria:

          1. Men and women ≥ 18 years of age.

          2. ECOG performance status of 0 to 2.

          3. Diagnosis of CLL that meets published diagnostic criteria (Hallek 2008):

               1. Monoclonal B-cells (either kappa or lambda light chain restricted) that are
                  clonally co-expressing ≥ 1 B-cell marker (CD19, CD20, or CD23) and CD5.

               2. Prolymphocytes may comprise ≤ 55% of blood lymphocytes.

               3. Presence of ≥ 5 x 10^9 B lymphocytes/L (5000/μL) in the peripheral blood (at any
                  point since initial diagnosis).

          4. Must have documented CD20-positive CLL.

          5. Active disease meeting ≥ 1 of the following IWCLL 2008 criteria for requiring
             treatment:

               1. Evidence of progressive marrow failure as manifested by the development of, or
                  worsening of, anemia (hemoglobin < 10 g/dL) and/or thrombocytopenia (platelets <
                  100,000/μL).

               2. Massive (i.e., ≥ 6 cm below the left costal margin), progressive, or symptomatic
                  splenomegaly.

               3. Massive nodes (i.e., ≥ 10 cm in the longest diameter), progressive, or
                  symptomatic lymphadenopathy.

               4. Progressive lymphocytosis with an increase of > 50% over a 2-month period or a
                  LDT of < 6 months. LDT may be obtained by linear regression extrapolation of ALC
                  obtained at intervals of 2 weeks over an observation period of 2 to 3 months. In
                  subjects with initial blood lymphocyte counts of < 30 x 10^9/L (30,000/μL), LDT
                  should not be used as a single parameter to define indication for treatment. In
                  addition, factors contributing to lymphocytosis or lymphadenopathy other than CLL
                  (e.g., infections) should be excluded.

               5. Autoimmune anemia and/or thrombocytopenia that is poorly responsive to standard
                  therapy.

               6. Constitutional symptoms documented in the subject's chart with supportive
                  objective measures, as appropriate, defined as ≥ 1 of the following
                  disease-related symptoms or signs:

             i. Unintentional weight loss ≥ 10% within the previous 6 months before screening.

             ii. Significant fatigue (ECOG performance score 2; inability to work or perform usual
             activities).

             iii. Fevers higher than 100.5°F or 38.0°C for ≥ 2 weeks before screening without
             evidence of infection.

             iv. Night sweats for > 1 month before screening without evidence of infection.

          6. Meet the following laboratory parameters:

               1. ANC ≥ 750 cells/μL (0.75 x 10^9/L), or ≥ 500 cells/μL (0.50 x 10^9/L) in subjects
                  with documented bone marrow involvement, and independent of growth factor support
                  7 days before assessment.

               2. Platelet count ≥ 50,000 cells/μL (50 x 10^9/L), or ≥ 30,000 cells/μL (30 x
                  10^9/L) in subjects with documented bone marrow involvement, and without
                  transfusion support 7 days before assessment. Subjects with transfusion-dependent
                  thrombocytopenia are excluded. If an Investigator has chosen
                  bendamustine/rituximab as the Arm B treatment, platelets must be ≥ 75,000
                  cells/μL (75 x 10^9/L).

               3. Serum AST and ALT ≤ 2.0 x ULN.

               4. Total bilirubin ≤ 1.5 x ULN.

               5. Estimated creatinine clearance of ≥ 30 mL/min, calculated using the formula of
                  Cockcroft and Gault [(140-Age) • Mass (kg)/(72 • creatinine mg/dL); multiply by
                  0.85 if female].

          7. Must have received ≥ 1 prior systemic therapies for CLL. Note: Single-agent steroids
             or localized radiation are not considered a prior line of therapy. If a single-agent
             anti-CD20 antibody was previously administered, subjects must have received ≥ 2 doses.

          8. Women who are sexually active and can bear children must agree to use highly effective
             forms of contraception while on the study and for 2 days after the last dose of
             acalabrutinib, 90 days after the last dose of idelalisib, 6 months after the last dose
             of bendamustine, or 12 months after the last dose of rituximab, whichever is longer.
             Highly effective forms of contraception are defined in Section 9.2.5.

          9. Men who are sexually active and can beget children must agree to use highly effective
             forms of contraception during the study and for 90 days after the last dose of
             idelalisib, 6 months after the last dose of bendamustine, or 12 months after the last
             dose of rituximab, whichever is longer. Highly effective forms of contraception are
             defined in Section 9.2.5.

         10. Men must agree to refrain from sperm donation during the study and for 90 days after
             the last dose of idelalisib, 6 months after the last dose of bendamustine, or 12
             months after the last dose of rituximab, whichever is longer.

         11. Willing and able to participate in all required evaluations and procedures in this
             study protocol, including swallowing capsules without difficulty.

         12. Ability to understand the purpose and risks of the study and provide signed and dated
             informed consent and authorization to use protected health information (in accordance
             with national and local patient privacy regulations).

        Exclusion Criteria:

          1. Known CNS lymphoma or leukemia.

          2. Known prolymphocytic leukemia or history of, or currently suspected, Richter's
             syndrome.

          3. Uncontrolled AIHA or ITP defined as declining hemoglobin or platelet count secondary
             to autoimmune destruction within the screening period or requirement for high doses of
             steroids (> 20 mg daily of prednisone or equivalent).

          4. Prior exposure to a BCL-2 inhibitor (e.g., venetoclax/ABT-199) or a BCR inhibitor
             (e.g., BTK inhibitors or PI3K inhibitors). Prior bendamustine is allowed if
             Investigator's choice for treatment in Arm B is idelalisib with rituximab.
             Bendamustine retreatment is allowed if the prior response to bendamustine lasted > 24
             months.

          5. Received any chemotherapy, external beam radiation therapy, anticancer antibodies, or
             investigational drug within 30 days before first dose of study drug.

          6. Corticosteroid use > 20 mg daily prednisone equivalent within 1 week before first dose
             of study drug, except as indicated for other medical conditions such as inhaled
             steroid for asthma, topical steroid use, or as premedication for administration of
             study drug or contrast. For example, subjects requiring steroids at daily doses > 20
             mg prednisone equivalent systemic exposure daily, or those who are administered
             steroids for leukemia control or white blood cell count lowering are excluded.

          7. Prior radio- or toxin-conjugated antibody therapy.

          8. Prior allogeneic stem cell transplant or prior autologous transplant within 6 months
             of first dose of study drug(s) or presence of graft-vs-host disease or receiving
             treatment for graft-vs-host disease.

          9. Major surgical procedure within 30 days of first dose of study drug. Note: If a
             subject had major surgery, they must have recovered adequately from any toxicity
             and/or complications from the intervention before the first dose of study drug.

         10. History of prior malignancy except for the following:

               1. Malignancy treated with curative intent and with no evidence of active disease
                  present for more than 2 years before screening and felt to be at low risk for
                  recurrence by treating physician.

               2. Adequately treated lentigo maligna melanoma without current evidence of disease
                  or adequately controlled nonmelanomatous skin cancer.

               3. Adequately treated carcinoma in situ without current evidence of disease.

         11. Significant cardiovascular disease such as uncontrolled or untreated symptomatic
             arrhythmias, congestive heart failure, or myocardial infarction within 6 months of
             screening, or any Class 3 or 4 cardiac disease as defined by the New York Heart
             Association Functional Classification, or QTc > 480 msec (calculated using
             Fridericia's formula: QT/RR^0.33) at screening. Exception: Subjects with controlled,
             asymptomatic atrial fibrillation during screening are allowed to enroll on study.

         12. Malabsorption syndrome, disease significantly affecting gastrointestinal function, or
             resection of the stomach, or extensive small bowel resection that is likely to affect
             absorption, symptomatic inflammatory bowel disease, or partial or complete bowel
             obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass.

         13. Received a live virus vaccination within 28 days of first dose of study drug.

         14. Known history of infection with HIV or any uncontrolled active systemic infection
             (e.g., bacterial, viral, or fungal). For study sites in Germany: active infection with
             human immunodeficiency virus (seropositivity for HIV-1 or HIV-2 antibodies, and if
             positive, reactivity against the HIV-specific p24 antigen).

         15. Active CMV infection (active viremia as evidenced by positive polymerase chain
             reaction [PCR] result for CMV DNA).

         16. Serologic status reflecting active hepatitis B or C infection.

               1. Subjects who are anti-HBc positive and who are surface antigen negative will need
                  to have a negative PCR result before randomization. Those who are HbsAg-positive
                  or hepatitis B PCR positive will be excluded.

               2. Subjects who are hepatitis C antibody positive will need to have a negative PCR
                  result before randomization. Those who are hepatitis C PCR positive will be
                  excluded.

         17. Ongoing, drug-induced liver injury, alcoholic liver disease, non-alcoholic
             steatohepatitis, primary biliary cirrhosis, ongoing extrahepatic obstruction caused by
             cholelithiasis, cirrhosis of the liver, or portal hypertension.

         18. History of or ongoing drug-induced pneumonitis.

         19. History of serious allergic reactions including anaphylaxis and toxic epidermal
             necrolysis.

         20. History of stroke or intracranial hemorrhage within 6 months before first dose of
             study drug.

         21. History of bleeding diathesis (e.g., hemophilia, von Willebrand disease).

         22. Requires or receiving anticoagulation with warfarin or equivalent vitamin K
             antagonists (e.g., phenprocoumon) within 7 days of first dose of study drug.

         23. Presence of a gastrointestinal ulcer diagnosed by endoscopy within 3 months before
             screening.

         24. Requires treatment with a strong CYP3A inhibitor/inducer.

         25. Requires treatment with proton-pump inhibitors (e.g., omeprazole, esomeprazole,
             lansoprazole, dexlansoprazole, rabeprazole, or pantoprazole). Subjects receiving
             proton-pump inhibitors who switch to H2-receptor antagonists or antacids are eligible
             for enrollment to this study.

         26. Breast feeding or pregnant.

         27. Concurrent participation in another therapeutic clinical trial.

         28. Prothrombin time/INR or aPTT (in the absence of a Lupus anticoagulant) > 2.0 x ULN.
             Exception: Subjects receiving warfarin are excluded, however, those receiving other
             anticoagulant therapy who have a higher INR/aPTT may be permitted to enroll to this
             study after discussion with the medical monitor.

         29. History of confirmed progressive multifocal leukoencephalopathy (PML)