Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique
Condition: Dental Caries
MeSH terms: Dental Caries
Intervention: Nano silver fluoride solution; Cavity Cleanser
Intervention description: Nano silver fluoride that composed of silver nanoparticles, chitosan and fluoride that combines preventive and antimicrobial properties.; Moistens dentin surface after cavity preparation using a micro brush.
Intervention MeSH terms: Chlorhexidine; Chlorhexidine gluconate; Pharmaceutical Solutions; Fluorides
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Enrollment: 44.0
Sex: All
Minimum age: 18 Years
Maximum age: 40 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      -  The teeth of the patients that meet inclusion criteria will be anesthetized, isolated
           with a rubber dam.

        -  Cavity opened using conventional high-speed rotary instruments.

        -  The central cariogenic biomass and the superficial parts of the necrotic dentine will be
           removed with round burs.

        -  Caries lesion will be completely removed in the enamel/dentin junction.

        -  The excavation procedure will be terminated as soon as the soft and wet dentine was
           removed and the remaining tissue was leathery but not hard on exploring.

        -  A dentinal sample will then be collected from the base of the cavity using sterile spoon
           excavator as a baseline for bacteriological assessment.

        -  Then, application of either intervention or control agent, another dentinal sample will
           be collected using a sterile excavator and transferred into sterile tubes and
           transferred to the laboratory for microbiological analysis.

        -  Filling of the cavity with resin composite restoration.

        -  All clinical procedures will be carried out at the same visit.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Inclusion Criteria of participants:

               1. Not received antibiotic therapy since 1 month before sampling.

               2. Good oral hygiene.

               3. Co-operative patients approving the trial.

          -  Inclusion Criteria of teeth:

               1. Class I deep caries lesions in permanent molar (reaching ≥ 1/2 of the dentin on
                  radiographic examination).

               2. Absence of spontaneous pain; negative sensitivity to percussion; and absence of
                  periapical lesions (radiographic examination).

        Exclusion Criteria:

          -  Exclusion criteria of participants:

               1. Pregnancy.

               2. Systemic disease or severe medical complications.

               3. Heavy smoking.

               4. Xerostomia.

               5. Lack of compliance.

          -  Exclusion criteria of teeth:

               1. Class II caries lesion.

               2. Shallow or enamel caries.

               3. Cuspal loss or caries beneath the gingival margin.