Investigate Oral Bacteria in Adult Population
Condition: Oral Bacteria
Intervention: Fluoride; Fluoride, Triclosan; Stannous Fluoride
Intervention description: Brush twice a day for 14 days; Brush twice daily for 14 days; Brush twice daily for 14 days
Intervention MeSH terms: Triclosan; Fluorides; Tin Fluorides
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Enrollment: 24.0
Sex: All
Minimum age: 18 Years
Maximum age: 70 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      To compare the antimicrobial efficacy of three dentifrices on oral bacteria
    

Eligibility criteria:

        Inclusion Criteria:

          -  Males and females in good general health aged 18 to 70 years.

          -  A willingness to read, understand, and sign the Informed Consent Form after the nature
             of the study has been fully explained to them. Subject should demonstrate a
             willingness to comply with all study procedures and sampling schedules.

          -  A minimum of 20 natural teeth with facial and lingual scorable surfaces.

          -  Adequate oral hygiene and no signs of oral neglect.

          -  Good periodontal health. Enrolled subjects will have periodontal pockets no greater
             than 5 mm.

          -  Gingival and plaque indices will also be measured during the first visit. Subjects
             with gingival index greater than or equal to 1.5 (Lobene Index) and plaque index
             greater than or equal to 1.5 (Turesky modification of Quigley-Hein Index) will be
             enrolled.

        Exclusion Criteria:

          -  History of significant adverse effects following use of oral hygiene products such as
             toothpastes and mouthrinses. Allergy to personal care/consumer products or their
             ingredients. Previous known allergy to dental materials, particularly to acrylic-like
             materials used to fabricate the stent device (this is a highly unlikely occurrence).

          -  Teeth that are grossly carious, fully crowned or extensively restored on facial and/or
             lingual surfaces, orthodontically banded, abutments, or third molars

          -  Difficulty having dental impressions taken such as excessive gagging.

          -  History of diabetes or hepatic or renal disease, or other serious medical conditions
             or transmittable diseases, e.g. heart disease or AIDS.

          -  History of rheumatic fever, heart murmur, mitral valve prolapse or other conditions
             requiring prophylactic antibiotic coverage prior to invasive dental procedures.

          -  Subjects on antibiotic, antiinflammatory or anticoagulant therapy during the month
             preceding the baseline exam.

          -  Significant oral soft tissue pathology, systemically related gingival enlargement,
             severe gingivitis (based on a visual examinations).

          -  History of active severe periodontal disease with bleeding gums and loose teeth.

          -  Gross dental caries, severe generalized cervical abrasion and/or enamel abrasion,
             large fractured or temporary restorations (based on visual examinations).will not be
             included in the tooth count.

          -  Fixed or removable orthodontic appliance or removable partial dentures.

          -  Participation in a dental plaque/gingivitis clinical study involving oral care
             products, within the last 30 days. History of dental prophylaxis or treatments in the
             past month.

          -  Self reported pregnancy or lactation.

          -  History or current use of objects to pierce the lips or tongue.

          -  Subjects known to be an alcoholic, or a recovering alcoholic.

          -  History or current use of recreational drugs.