Effect of 2-h Infusion of ON 01910.Na in Ovarian Cancer Patients
Condition: Ovarian Cancer
MeSH terms: Ovarian Neoplasms; Carcinoma, Ovarian Epithelial
Intervention: ON 01910.Na
Intervention MeSH terms: ON 01910
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 1.0
Sex: Female
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Ovarian; Cancer; Cisplatin; Carboplatin

Summary:

      ON 01910.Na has undergone preclinical and clinical phase I studies showing activity in
      patients with progressing ovarian cancer resistant to platinum-based chemotherapies. This
      study will look at a larger population of patients to determine whether treatment with ON
      01910.Na has an effect on progression free survival rates in patients with platinum-resistant
      ovarian cancer. ON 01910.Na will be given as an intravenous infusion over 2 hours on days 1,
      4, 8, 11, 15, and 18 of a 28-day cycle. Patients will be treated for 6 or more cycles.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Women with ovarian cancer at least 18 years old with measurable disease who have shown
             recurrent disease within 6 months of the last dose of cisplatin- or carboplatin-based
             chemotherapy. Measurable disease will be defined as lesions that can be accurately
             measured in at least one dimension with longest diameter ≥ 20 mm using conventional
             techniques or ≥ 10 mm with spiral CT scan.

          -  Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1 or 2.

          -  No more than 3 prior chemotherapy regimens.

          -  Disease-free period of more than 5 years from prior malignancies other than ovarian
             (except curatively treated basal cell carcinoma, squamous cell carcinoma of the
             skin,or carcinoma in situ of the cervix).

          -  All female patients of childbearing potential must use at least one form of
             contraception as approved by the Investigator prior to study entry and for up to 30
             days beyond the last administration of study drug.

          -  Women of childbearing potential must have a negative serum βHCG pregnancy test at
             screening.

          -  Willing to adhere to the prohibitions and restrictions specified in this protocol.

          -  Patient (or her legally authorized representative) must have signed an informed
             consent document.

        Exclusion Criteria:

          -  Evidence of complete or partial bowel obstruction.

          -  Need for IV hydration or Total Parenteral Nutrition.

          -  Inability to comply with study and/or follow-up procedures.

          -  Life expectancy of less than 12 weeks.

          -  Prior radiotherapy to greater than one third of hematopoietic sites.

          -  Uncontrolled intercurrent illness including, but not limited to symptomatic congestive
             heart failure, unstable angina pectoris or cardiac arrhythmia.

          -  Active infection not adequately responding to appropriate therapy.

          -  Hyponatremia (defined as serum sodium value of <134 mEq/L).

          -  Total bilirubin ≥ 1.5 mg/dL not related to hemolysis or Gilbert's disease, AST/ALT or
             alkaline phosphatase ≥ 2 X ULN.

          -  Serum creatinine ≥ 2.0 mg/dL.

          -  ANC < 1500/mm3, platelets < 100,000/mm3; hemoglobin less than 9 g/dL.

          -  Ascites requiring active medical management including paracentesis for more than twice
             a month.

          -  Women patients who are pregnant or lactating or have a positive serum βHCG pregnancy
             test at screening.

          -  Major surgery without full recovery or major surgery within 3 weeks of ON 01910.Na
             treatment start.

          -  Uncontrolled hypertension (defined as a systolic pressure ≥ 160 and/or a diastolic
             pressure ≥ 110).

          -  New onset seizures (within 3 months prior to the first dose of ON 01910.Na) or poorly
             controlled seizures.

          -  Brain metastases including any of the following:

               1. Evidence of cerebral edema by CT scan or MRI.

               2. Evidence of disease progression on prior imaging studies.

               3. Requirement for steroids.

               4. Clinical symptoms of brain metastases.

          -  Any concurrent and/or within 4 weeks of the first dose of study drug investigational
             agent or chemotherapy, radiotherapy or immunotherapy.

          -  Psychiatric illness/social situations that would limit the patient's ability to
             tolerate and/or comply with study requirements.