Botulinum Toxin Injection for the Management of BPH
Condition: Benign Prostatic Hyperplasia
MeSH terms: Prostatic Hyperplasia; Hyperplasia
Intervention: botulinum toxin type A (BoNT/A)
Intervention description: 100 unit and 300 unit dosages: Dilute each 100 U vial with 1.3 ml of normal saline. Each reconstituted vial is then drawn up into a single syringe with a total of 4 ml = 300 U. The instrument used to inject the botulinum toxin is an ultrasound device with a transrectal ultrasound probe specially designed for prostate biopsies which has a special canal to introduce and direct a needle in to the selected prostatic area.
Intervention MeSH terms: Botulinum Toxins; Botulinum Toxins, Type A; abobotulinumtoxinA
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 134.0
Sex: Male
Minimum age: 50 Years
Healthy volunteers: No
Keywords: benign prostatic hyperplasia; BPH; botulinum toxin; BoNT/A

Summary:

      This is a double-blind randomized phase II trial to determine whether two different doses of
      BoNT/A injection into the prostate gland demonstrate sufficient improvement in the management
      of lower urinary symptoms due to BPH to warrant more extensive research. Subjects will
      receive either a 100U or 300U dose. Participation will last 1 year.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Male at least 50 years of age.

          -  Voided volume => 125 ml.

          -  Maximum urinary flow < 15 ml/sec.

          -  AUA symptom severity score => 8.

          -  Patient signed informed consent prior to the performance of any study procedures.

          -  Patient able to complete the study protocol in the opinion of the investigator.

        Exclusion Criteria:

          -  Any prior surgical intervention for BPH.

          -  Current diagnosis of acute or chronic prostatitis (which may cause LUTS that mimic
             BPH).

          -  Overactive bladder without bladder outlet obstruction.

          -  Enrolled in another treatment trial for any disease within the past 30 days.

          -  Men interested in future fertility.

          -  Previous exposure to botulinum toxin.

          -  On alpha-blocker within the past 48 hours.

          -  On any 5-alpha-reductase inhibitor within the past month.

          -  Post void residual > 350 ml.

          -  On phenylephrine, pseudoephedrine, imipramine, an anticholinergic, or cholinergic
             medication within the past 2 weeks.

          -  On estrogen, androgen, any drug producing androgen suppression, or anabolic steroids
             within the past 4 months.

          -  Clinically significant renal or hepatic impairment as determined by abnormal
             creatinine or AST levels (based on local institutional values).

          -  Serum prostate specific antigen level > 8 ng/ml (Hybritech). For those with a PSA
             between 4-8 ng/ml, the PSA elevation must be considered to be from a benign cause in
             the opinion of the PI. This decision can be based on PSA velocity, previous TRUS
             biopsy, percent free PSA, or other clinical estimations in keeping with sound urologic
             care.

          -  Active urinary tract disease or biopsy of the prostate within the past 6 weeks.

          -  Daily use of a pad or device for incontinence required.

          -  Episode of unstable angina pectoris, myocardial infarction, transient ischemic attack,
             or cerebrovascular accident (stroke) within the past 6 months.

          -  On aminoglycosides or any drug that interfere with neuromuscular transmission.

          -  Eaton-Lambert syndrome, hemophilia, hereditary clotting factors deficiency, or
             bleeding diathesis.

          -  Penile prosthesis or artificial urinary sphincter.

          -  History or current evidence of carcinoma of the prostate or bladder, pelvic radiation
             or surgery, urethral stricture, or bladder neck obstruction.

          -  Known primary neurologic conditions such as multiple sclerosis, myasthenia gravis or
             Parkinson's disease, or other neurological diseases known to affect bladder function.

          -  Documented bacterial or acute prostatitis within the past year.

          -  Two documented urinary tract infections of any type in the past year (UTI defined as >
             100,000 colonies per ml urine from midstream clean catch or catheterized specimen).

          -  History of bladder calculi.

          -  Patients must be off aspirin, NSAIDS, and Coumadin for 7 or more days prior to
             botulinum toxin injection.

          -  Cancer that is not considered cured, except basal cell or squamous cell carcinoma of
             the skin (cured defined as no evidence of cancer within the past 5 years).

          -  Any serious medical condition likely to impede successful completion of the study,
             such as certain mental disorders, hypersensitivity to botulinum toxin or anesthetics
             used in the study, syncope, uncontrolled diabetes.