Pazopanib in Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)
Condition: Gastrointestinal Stromal Tumor (GIST)
MeSH terms: Gastrointestinal Stromal Tumors
Intervention: Pazopanib
Intervention description: 800 mg; PO
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 25.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This study is being done to gather information about the safety (any harmful effects) and
      effectiveness (usefulness) of Pazopanib in the treatment of Gastrointestinal Stroma Tumors
      (GIST) that cannot be treated by surgery or has spread to other organs. The Food and Drug
      Administration (FDA) have approved Pazopanib for the treatment of advanced kidney cancer but
      it is not approved for the treatment of GIST. The investigators hope to learn about the
      safety and usefulness (effectiveness) of Pazopanib for patients with GIST.

      Primary Objective:

      Non-progression rate based on RECIST criteria (CR+PR+SD)

      Secondary Objectives:

        -  Response per Choi criteria

        -  6 month progression-free survival

        -  Safety and tolerability
    

Eligibility criteria:

        Inclusion Criteria:

          -  Metastatic or unresectable gastrointestinal stromal tumor (GIST)

          -  Failure or intolerance to Imatinib and sunitinib

          -  Subjects must provide written informed consent prior to performance of study-specific
             procedures or assessments, and must be willing to comply with treatment and follow up.

          -  Procedures conducted as part of the subject's routine clinical management (e.g., blood
             count, imaging study) and obtained prior to signing of informed consent may be
             utilized for screening or baseline purposes provided these procedures are conducted as
             specified in the protocol.

          -  Age >= 18 years

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

          -  Measurable disease criteria by RECIST criteria

          -  Adequate organ system function as defined in protocol.

          -  A female is eligible to enter and participate in this study if she is of
             non-childbearing potential (i.e., physiologically incapable of becoming pregnant).
             This includes any female who has had:

          -  A hysterectomy

          -  A bilateral oophorectomy (ovariectomy)

          -  A bilateral tubal ligation

          -  Menopause

          -  Childbearing potential females must have a negative serum pregnancy test within 2
             weeks prior to the first dose of study treatment, preferably as close to the first
             dose as possible, and agree to use adequate contraception. Adequate acceptable
             contraceptive methods, when used consistently and in accordance with both the product
             label and the instructions of the physician, are as follow:

          -  An intrauterine device with a documented failure rate of less than 1% per year.

          -  Vasectomized partner who is sterile prior to the female subject?s entry and is the
             sole sexual partner for that female.

          -  Complete abstinence from sexual intercourse for 14 days before exposure to
             investigational product, through the dosing period, and for at least 21 days after the
             last dose of investigational product.

        Double-barrier contraception (condom with spermicidal jelly, foam suppository, or film;
        diaphragm with spermicide; or male condom and diaphragm with spermicide edify eligible
        disease(s)/stage(s)

        Exclusion Criteria:

          -  History of other malignancies within 5 years prior to Day 1 except for tumors with a
             negligible risk for metastasis or death, such as adequately controlled basal cell
             carcinoma, squamous-cell carcinoma of the skin, carcinoma in situ of the cervix,
             early-stage bladder cancer, or low-grade endometrial cancer

          -  Clinically significant gastrointestinal abnormalities that may affect absorption of
             the investigational product

          -  Presence of uncontrolled infection

          -  Prolongation of corrected QT interval (QTc) > 480 milliseconds. On antiarrhythmics or
             medications known to prolong QT interval

          -  History of any one or more of the following cardiovascular conditions within the past
             6 months:

          -  Cardiac angioplasty or stenting

          -  Myocardial infarction

          -  Unstable angina

          -  Coronary artery by-pass graft surgery

          -  Symptomatic peripheral vascular disease

          -  Class III or IV congestive heart failure, as defined by the New York Heart Association
             (NYHA)

          -  Poorly controlled hypertension [defined as systolic blood pressure (SBP) of >=140 mmHg
             or diastolic blood pressure (DBP) of >= 90mmHg].

          -  History of cerebrovascular accident, hemoptysis, cerebral hemorrhage, clinically
             significant GI bleed, pulmonary embolism or untreated deep venous thrombosis (DVT)
             within the past 6 months

          -  Prior major surgery or trauma within 28 days prior to first dose of study drug and/or
             presence of any non-healing wound, fracture

          -  Evidence of active bleeding or bleeding diathesis.

          -  Any serious and/or unstable pre-existing medical, psychiatric, or other condition that
             could interfere with subject's safety, provision of informed consent, or compliance to
             procedures.

          -  Patients on strong CYP3A4 inhibitors

          -  Uncorrected abnormal electrolytes- K, Mg and Ca

          -  Treatment with any of the following anti-cancer therapies:

          -  o radiation therapy, surgery or tumor embolization within 14 days prior to the first
             dose of pazopanib OR

          -  o chemotherapy, immunotherapy, biologic therapy, investigational therapy or hormonal
             therapy within 14 days or five half-lives of a drug (whichever is longer) prior to the
             first dose of pazopanib