Evaluation of Enzastaurin in the Treatment of Persistent or Recurrent Ovarian or Primary Peritoneal Cancer
Condition: Ovarian Cancer; Neoplasms; Carcinoma
MeSH terms: Carcinoma
Intervention: enzastaurin
Intervention description: 1125 mg loading dose then 500 mg, oral, daily, until progressive disease
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Sequential Assignment
Masking: None (Open Label)
Enrollment: 28.0
Sex: Female
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Recurrent Cancer

Summary:

      The purpose is to assess the efficacy and toxicity of the study agent, enzastaurin, in
      participants with recurrent or persistent ovarian cancer.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Participants must have recurrent or persistent epithelial ovarian or primary
             peritoneal carcinoma.

          -  All participants must have measurable disease.

          -  Participants must have at least one "target lesion" to be used to assess response on
             this protocol.

          -  Participants must not be eligible for a higher priority GOG protocol, if one exists.

          -  Participants who have received one prior regimen must have a GOG Performance Status of
             0, 1, or 2. Participants who have received two prior regimens must have a GOG
             Performance Status of 0 or 1.

          -  Any hormonal therapy directed at the malignant tumor must be discontinued at least one
             week prior to registration. Continuation of hormone replacement therapy is permitted.

          -  Any other prior therapy directed at the malignant tumor, including immunologic agents,
             must be discontinued at least four weeks prior to registration.

          -  Participants must have had one prior platinum-based chemotherapeutic regimen for
             management of primary disease containing carboplatin, cisplatin, or another
             organoplatinum compound.

          -  Participants must NOT have received any non-cytotoxic therapy for management of
             recurrent or persistent disease.

          -  Participants of child-bearing potential must have a negative serum pregnancy test
             prior to study entry and be practicing an effective form of contraception (for
             example, intrauterine device [IUD], birth control pills, or barrier device) during and
             for 3 months after discontinuation of study treatment.

        Exclusion Criteria:

          -  Participants with previous enzastaurin treatment.

          -  Participants who have received radiation to more than 25% of marrow-bearing areas

          -  Participants with other invasive malignancies, with the exception of non-melanoma skin
             cancer, who had (or have) any evidence of other cancer present within the last 5 years
             or whose previous cancer treatment contraindicates this protocol therapy.

          -  Participants who have received treatment within the last 30 days with a drug that has
             not received regulatory approval for any indication at the time of study entry.

          -  Participants who are unable to discontinue use of carbamazepine, phenobarbital, and
             phenytoin (refer to Concomitant Medications for a discussion of enzyme inducing
             anti-epileptic drugs [EIAEDs]).

          -  Participants who are receiving concurrent administration of any other systemic
             anticancer therapy except for a biphosphonate if patient has bony metastases.

          -  Participants who have received prior therapy with non-cytotoxic agents (i.e.
             bevacizumab).

          -  Participants with serious concomitant systemic disorders (for example, active
             infection or abnormal electrocardiogram (ECG) indicative of cardiac disease) that, in
             the opinion of the investigator, would compromise the safety of the patient and
             his/her ability to complete the study.