Sunitinib in Treating Patients With Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia
Condition: Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Myelodysplastic Syndromes; Secondary Myelodysplastic Syndromes
MeSH terms: Leukemia; Preleukemia; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Myelodysplastic Syndromes; Syndrome
Intervention: sunitinib malate
Intervention description: Given orally
Intervention MeSH terms: Sunitinib
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 10.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This phase II trial is studying how well sunitinib works in treating patients with
      myelodysplastic syndromes or chronic myelomonocytic leukemia. Sunitinib may stop the growth
      of abnormal cells by blocking some of the enzymes needed for cell growth.
    

Eligibility criteria:

        Inclusion Criteria:

          -  MDS syndromes meeting 1 of the following: Intermediate-2 disease, high-risk disease
             (IPSS score>=1.5)

          -  CMML: WBC>12,000/mm^3, Intermediate-2 disease with WBC=<12,000/mm^3, high-risk disease
             (IPSS score>=1.5) with WBC=<12,000/mm^3

          -  Patients with insufficient/inadequate metaphases for cytogenetic analysis are eligible
             if bone marrow blasts are >10% and/or 2-3 cytopenias are present

          -  No known brain metastases

          -  Life expectancy>12 weeks

          -  ECOG PS 0-2/Karnofsky PS 60-100%

          -  Calcium=<3.0 mmol/L

          -  Bilirubin normal

          -  AST and ALT=<2.5 times upper limit of normal

          -  Creatinine normal/creatinine clearance>=60 mL/min

        Exclusion Criteria:

          -  No history of significant ECG abnormalities including but not limited to: ventricular
             arrhythmias (ventricular tachycardia, ventricular fibrillation>=3 beats in a row); QTc
             prolongation (i.e.QTc interval>=500msec)

          -  No history of allergic reaction to compounds of similar chemical/biological
             composition to sunitinib malate

          -  No NYHA class III-IV congestive heart failure

          -  Patients with history of NYHA class II congestive heart failure who are asymptomatic
             on treatment are eligible

          -  No abdominal fistula/G perforation/intraabdominal abscess within past 28 days

          -  No serious cardiovascular disease within past 12 months including: cerebrovascular
             accident or transient ischemic attack, myocardial infarction, cardiac arrhythmia,
             stable or unstable angina, symptomatic congestive heart failure, coronary or
             peripheral artery bypass graft or stenting

          -  No pulmonary embolism within past 12 months

          -  No uncontrolled hypertension (systolic BP>=140 mmHg/diastolic BP>=90 mmHg)

          -  No condition impairing ability to swallow/retain sunitinib malate tablets including:
             GI tract disease resulting in inability to take oral medication, requirement for IV
             alimentation, prior surgical procedures affecting absorption, active peptic ulcer
             disease

          -  No serious/nonhealing wound, ulcer, or bone fracture

          -  No uncontrolled pre-existing thyroid abnormality

          -  No concurrent uncontrolled illness including ongoing/active infection

          -  No psychiatric illness/social situation that would preclude study participation

          -  Not pregnant/nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective barrier contraception

          -  4 weeks since prior major surgery

          -  Prior central thoracic radiotherapy that included heart in radiotherapy port allowed
             provided NYHA congestive heart failure=<class II

          -  Prior anthracycline exposure allowed provided NYHA congestive heart failure=<class II

          -  No other prior therapy for MDS/CMML except epoetin alfa, darbepoetin alfa, filgrastim
             or sargramostim

          -  At least 2 weeks since prior epoetin alfa

          -  At least 4 weeks since prior darbepoetin alfa

          -  No other prior antiangiogenic agents including but not limited to: bevacizumab,
             sorafenib tosylate, pazopanib hydrochloride, AZD2171, vatalanib, VEGF Trap

          -  More than 7 days since prior and no concurrent potent CYP3A4 inhibitors

          -  More than 12 days since prior and no concurrent potent CYP3A4 inducers including:
             Rifampin, Rifabutin, Carbamazepine, Phenobarbital, Phenytoin, Hypericum perforatum,
             Efavirenz, Tipranavir

          -  No concurrent birth control patch/oral birth control pills/depot/injectable birth
             control methods

          -  No concurrent therapeutic coumarin-derivative anticoagulants

          -  Low dose(=<2mg) warfarin for prophylaxis of thrombosis allowed

          -  Low molecular weight heparin allowed if INR=<1.5

          -  No concurrent agents with proarrhythmic potential including: Terfenadine, Quinidine,
             Procainamide, Disopyramide, Sotalol, Probucol, Bepridil, Haloperidol, Risperidone,
             Indapamide, Flecainide acetate

          -  No concurrent combination antiretroviral therapy for HIV-positive patients

          -  No other concurrent investigational agents