Study With IMC-A12 (Cixutumumab) in Patients Who Have Not Previously Been Treated With Chemotherapy With Metastatic Prostate Cancer
Condition: Adenocarcinoma of the Prostate
MeSH terms: Prostatic Neoplasms
Intervention: IMC-A12 (Cixutumumab)
Intervention description: 10 mg/kg i.v. infusion over 1 hour every 2 weeks or 20 mg/kg i.v. infusion over 1 hour every 3 weeks.
Intervention MeSH terms: Antibodies, Monoclonal
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 41.0
Sex: Male
Minimum age: 18 Years
Healthy volunteers: No
Keywords: prostate cancer

Summary:

      This single arm, multicenter, open-label, Phase II study will enroll chemotherapy-naive
      participants with metastatic, histologically-confirmed adenocarcinoma of the prostate (stage
      M1 D2). Treatment will continue until there is evidence of disease progression, intolerable
      toxicity, or other withdrawal criteria are met. Non-surgically castrated participants must
      continue the use of luteinizing hormone-releasing hormone (LHRH) agonists during protocol
      treatment.
    

Eligibility criteria:

        Inclusion Criteria

          -  The participant is male and at least 18 years of age

          -  The participant has histologically-confirmed adenocarcinoma of the prostate

          -  The participant has radiographic evidence of metastatic prostate cancer (stage M1
             [D2])

          -  The participant has prostate cancer unresponsive or refractory to hormone therapy

          -  The participant must have evidence of progressive disease defined as at least one of
             the following:

               -  a. Progressive measurable disease: using conventional solid tumor criteria.

               -  b. Bone scan progression: at least one new lesion on bone scan.

               -  c. Increasing prostate specific antigen (PSA): at least two consecutive rising
                  PSA values over a reference value (PSA #1) taken at least 1 week apart. A third
                  PSA (PSA #3) is required to be greater than PSA #2; if not, a fourth PSA (PSA #4)
                  is required to be greater than PSA #2

          -  The participant has a PSA ≥ 2 nanograms/milliliter (ng/mL)

          -  The participant has not received prior chemotherapy for metastatic prostate cancer

          -  The participant had prior surgical or medical castration with a serum testosterone
             level of < 50 ng/mL. If the method of castration is LHRH agonists, the participant
             must be willing to continue the use of LHRH agonists during protocol treatment

          -  All clinically significant toxic effects (excluding alopecia) of prior surgery,
             radiotherapy, or hormonal therapy have resolved to grade ≤ 1 based on National Cancer
             Institute - Common Terminology Criteria for Adverse Events, (NCI-CTCAE)Version 3.0

          -  The participant has not received antiandrogen therapy for at least 6 weeks (4 weeks
             for flutamide) prior to study entry and is without evidence of an antiandrogen
             withdrawal response. For participants whose progression is documented solely by PSA
             increase, the most recent PSA value enabling study entry must be drawn after the
             required antiandrogen washout period

          -  The participant has an Eastern Cooperative Oncology Group performance status (ECOG PS)
             of 0-1

          -  The participant has adequate organ function including: absolute neutrophil count ≥
             1500/microliter (μL); platelets ≥ 100,000/μL; hemoglobin ≥ 9.0 grams per deciliter
             (g/dL); bilirubin ≤ 1.5 times the institutional upper limit of normal (ULN); aspartate
             transaminase (AST) / alanine transaminase (ALT) ≤ 3 times ULN (< 5x ULN if liver
             metastases are present); creatinine ≤ 1.5 x ULN (or calculated creatinine clearance >
             60 milliliter/minute (mL/min); and urine protein ≤ 1+ (if urine protein is ≥ 2+, a
             24-hour urine collection must demonstrate < 1000 mg of protein in 24 hours to allow
             participation in the study)

          -  The participant has fasting serum glucose < 120 milligrams per deciliter (mg/dL) or
             below the ULN

          -  The participant has adequate coagulation function as defined by an international
             normalized ratio (INR) ≤ 1.5 and a partial thromboplastin time (PTT) ≤ 1.5 ULN (unless
             on oral anticoagulant therapy). Participants receiving full-dose anticoagulation
             therapy are eligible provided they meet all other criteria, are on a stable dose of
             oral anticoagulant or low molecular weight heparin (and if on warfarin have a
             therapeutic INR between 2 and 3)

          -  The participant is asymptomatic from prostate cancer. Participants with minimal,
             infrequent cancer-related symptoms are eligible. Criteria regarding pain and analgesic
             use are detailed below

          -  The participant has a life expectancy > 6 months

          -  The participant, if sexually active, agrees to use contraceptives while on study

          -  The participant has provided signed informed consent

        Exclusion Criteria

          -  The participant has any active malignancy (other than adequately treated
             nonmelanomatous skin cancer or other noninvasive or in situ neoplasms), or has an
             adequately-treated prior cancer but has been disease free for < 3 years

          -  The participant has an ongoing or active infection, symptomatic congestive heart
             failure, unstable angina pectoris, serious cardiac arrhythmia (well-controlled atrial
             fibrillation is permitted), psychiatric illness/social situations, active bleeding or
             pathological condition that carries a high risk of bleeding (eg, tumor involving major
             vessels, tumor invading to rectal lumen, or known varices), or any other serious
             uncontrolled medical disorder in the opinion of the investigator

          -  The participant has a known hypersensitivity to therapeutic protein products

          -  The participant has known or suspected brain or leptomeningeal metastases

          -  The participant has received radiotherapy ≤ 21 days prior to first dose of IMC-A12

          -  The participant has received prior radiation therapy to > 30% of the bone marrow or
             prior strontium-89, rhenium-186, rhenium-188, or samarium-153 (participants who have
             received standard dose radiation to the pelvis for prostate cancer and no additional
             radiotherapy are eligible)

          -  The participant has a known human immunodeficiency virus infection or acquired
             immunodeficiency syndrome-related illness

          -  The participant has received more than one course of radiotherapy to a single site of
             metastatic bony disease

          -  The participant has a bone scan that indicates "superscan" (that is (ie), extensive
             metastasis to bone in numerous areas, too numerous to count or define)

          -  The participant is receiving corticosteroids (dexamethasone, prednisone, or others)
             for anorexia, weight loss, analgesia or other cancer-related symptoms(Corticosteroids
             may not be instituted once a participant has begun therapy on-study

          -  The participant requires ongoing, regularly scheduled opiate analgesic therapy for
             cancer related pain. Intermittent, infrequent low-potency opiate-use (example,
             oxycodone, codeine) is permitted

          -  The participant has a history of prior treatment with other agents that specifically
             target the insulin-like growth factor (IGF) receptor