Monocyte Biomarkers in Moderate to Severe Plaque Psoriasis Subjects Treated With Apremilast
Condition: Plaque Psoriasis
MeSH terms: Psoriasis
Intervention: Apremilast
Intervention description: Apremilast will be given as approved by the FDA for the treatment of moderate to severe plaque psoriasis. An initial dosage titration from Day 1 (10mg) to Day 5 (30mg). Following the titration, the recommended maintenance dosage of 30 mg twice daily taken orally starting on Day 6 will be dispensed, as per labeled indication.
Intervention MeSH terms: Apremilast
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Intervention model description: This is an open label pilot study of the impact of treatment with standard dosing of APM for 16 weeks on AM-endotype psoriasis patients, identified by elevated (>150% of normal): 1.) Intermediate (CD14++CD16+) monocytes % of cells in circulation, or 2.) circulating monocyte doublets % of adherent monocyte-monocyte pairs, or 3.) circulating monocyte-platelet aggregates (MPA) % monocytes adherent to platelets.
Masking: None (Open Label)
Enrollment: 28.0
Sex: All
Minimum age: 18 Years
Maximum age: 60 Years
Healthy volunteers: No

Summary:

      This is an open label pilot study of the impact of treatment with standard dosing of Otezla
      for 16 weeks on AM-endotype psoriasis patients, identified by elevated (>150% of normal): 1.)
      Intermediate (CD14++CD16+) monocytes, or 2.) circulating monocyte doublets, or 3.)
      circulating monocyte-platelet aggregates (MPA).

      Approximately 25 psoriasis patients with the AM-endotype will be followed during treatment
      over 16 weeks with 4 monthly individual blood draws will be enrolled. All treated psoriasis
      subjects will receive apremilast through Week 16.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Males or females, ≥ 18 and < 60 years of age at the time of signing the informed
             consent document.

          2. Understand and voluntarily sign an informed consent document prior to any study
             related assessments/procedures being conducted.

          3. Able to adhere to the study visit schedule and other protocol requirements.

          4. Patients must exhibit AM-endotype psoriasis patients, identified by elevated (>150% of
             normal) levels of any one of the following criteria: 1.) Intermediate (CD14++CD16+)
             monocytes, or 2.) circulating monocyte doublets, or 3.) circulating monocyte-platelet
             aggregates (MPA).

          5. Diagnosis of chronic plaque psoriasis for at least 12 months prior to Screening.

          6. Have moderate to severe plaque psoriasis at Screening and Baseline as defined by a.
             BSA ≥5% b. sPGA ≥3 (moderate to severe)

          7. Must be a candidate for phototherapy and systemic (including Otezla) therapy.

          8. Must be in good health (except for psoriasis) as judged by the Investigator, based on
             medical history and physical examination.

          9. Females of childbearing potential (FCBP) must have a negative pregnancy test at
             Screening and Baseline. While on investigational product and for at least 28 days
             after taking the last dose of investigational product, FCBP who engage in activity in
             which conception is possible must use one of the approved contraceptive options
             described below:

        Option 1: Any one of the following highly effective methods: hormonal contraception (oral,
        injection, implant, transdermal patch, vaginal ring); intrauterine device (IUD); tubal
        ligation; or partner's vasectomy;

        OR

        Option 2: Male or female condom (latex condom or nonlatex condom NOT made out of natural
        [animal] membrane [for example, polyurethane]; PLUS one additional barrier method: (a)
        diaphragm with spermicide; (b) cervical cap with spermicide; or (c) contraceptive sponge
        with spermicide.

        The female subject's chosen form of contraception must be effective by the time the female
        subject is randomized into the study (for example, hormonal contraception should be
        initiated at least 28 days before randomization Male subjects (including those who have had
        a vasectomy) who engage in activity in which conception is possible must use barrier
        contraception (male latex condom or non-latex condom NOT made out of natural [animal]
        membrane [for example, polyurethane]) while on investigational product and for at least 28
        days after the last dose of investigational product.

        Exclusion Criteria:

          -  1. Other than psoriasis, history of any clinically significant (as determined by the
             Investigator) cardiac (clinically advanced cardiovascular disease including; Stent,
             past history of MI, thrombotic event or arterial calcification), endocrinologic,
             pulmonary, neurologic, psychiatric, hepatic, renal, hematologic, immunologic disease,
             or other major uncontrolled disease.

             2. Any condition, including the presence of laboratory abnormalities, which would
             place the subject at unacceptable risk if he/she were to participate in the study.

             3. Any condition, including other inflammatory diseases or dermatologic conditions
             that confound the ability to interpret data from the study.

             4. Prior history of suicide attempt at any time in the subject's life time prior to
             screening or randomization, or major psychiatric illness requiring hospitalization
             within the last 3 years.

             5. Pregnant or breast feeding.

             6. Have failed more than 3 systemic agents for treatment of psoriasis.

             7. History of allergy to any component of Apremilast.

             8. Hepatitis B surface antigen positive at Screening.

             9. Anti-hepatitis C antibody positive at Screening.

             10. Had a serious infection (including, but not limited to, hepatitis, pneumonia,
             sepsis, cellulitis, meningitis or pyelonephritis) or have been hospitalized for an
             infection. Subject must be cured of infection > 4 weeks before Screening.

             11. Have a history of, or ongoing, chronic or recurrent infectious disease, including,
             but not limited to, chronic renal infection, chronic chest infection (e.g.,
             bronchiectasis), sinusitis, recurrent urinary tract infection (e.g., recurrent
             pyelonephritis, chronic nonremitting cystitis), an open, draining, or infected skin
             wound or ulcer.

             12. Had a Bacillus Calmette-Guérin (BCG) vaccination within 1 year prior to screening.

             13. History of positive human immunodeficiency virus (HIV), or have congenital or
             acquired immunodeficiency (e.g., common variable immunodeficiency disease).

             14. Active substance abuse or a history of substance abuse within 6 months prior to
             Screening.

             15. Bacterial infections requiring treatment with oral or injectable antibiotics, or
             significant viral or fungal infections, within 4 weeks of Screening. Any treatment and
             cure for such infections must have been completed at least 4 weeks prior to Screening.

             16. Malignancy or history of malignancy, except for:

               1. treated [i.e., cured] basal cell or squamous cell in situ skin carcinomas;

               2. treated [i.e., cured] cervical intraepithelial neoplasia [CIN] or carcinoma in
                  situ of the cervix with no evidence of recurrence within the previous 5 years.

                  17. Topical therapy within 2 weeks of study entry (including, but not limited to,
                  topical corticosteroids, retinoids or vitamin D analog preparations, tacrolimus,
                  pimecrolimus, or anthralin/dithranol). Exceptions: low-potency corticosteroids to
                  cyclosporine, corticosteroids, methotrexate, retinoids, mycophenolate,
                  thioguanine, hydroxyurea, sirolimus, sulfasalazine, azathioprine, fumaric acid
                  esters) will be allowed as background therapy and restricted to treatment of the
                  face, axillae, and groin in accordance with the manufacturers' suggested usage
                  during the course of the study (this restricted usage should be documented).
                  Subjects with scalp psoriasis will be permitted to use coal tar shampoo and/or
                  salicylic acid scalp preparations on scalp lesions. An unmedicated skin
                  moisturizer (eg, Eucerin®) will be also permitted for body lesions only. Subjects
                  should not use these topical treatments within 24 hours prior to the clinic
                  visit.

                  18. Systemic therapy for psoriasis within 4 weeks prior to study entry
                  (including, but not limited to, cyclosporine, corticosteroids, methotrexate,
                  retinoids, mycophenolate, thioguanine, hydroxyurea, sirolimus, sulfasalazine,
                  azathioprine, and fumaric acid esters).

                  19. Use of phototherapy within 4 weeks prior to study entry.

                  20. Use of any investigational drug within 4 weeks prior to study entry, or 5
                  pharmacokinetic/pharmacodynamic half-lives, if known (whichever is longer).

                  21. Prolonged sun exposure or use of tanning booths or other ultraviolet (UV)
                  light sources.

                  22. Prior treatment with Apremilast

                  23. Inability to wash out from any topical treatment(s) (two weeks prior to
                  entering the study) or all systemic therapies, including orals and biologics
                  (e.g., TNF inhibitors IL-17 inhibitors, IL-12/23 inhibitors, 4 weeks).