A Study That Compares the Extent to Which Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug Containing Apomorphine or Apomorphine That is Injected Under the Skin in People With PD Complicated by "OFF" Episodes
Condition: Parkinson Disease
MeSH terms: Parkinson Disease
Intervention: APL-130277; APO-go; Apokyn
Intervention description: APL-130277 sublingual thin film; Subcutaneous APO-go; Subcutaneous APOKYN
Intervention MeSH terms: Apomorphine
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Enrollment: 8.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Off Episodes; Parkinson Disease

Summary:

      A study that compares the extent to which apomorphine becomes available in the body after
      taking either an investigational drug containing apomorphine or apomorphine that is injected
      under the skin in people with PD complicated by "OFF" episodes.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Male or female ≥ 18 years of age.

          2. Clinical diagnosis of Idiopathic PD, consistent with UK Brain Bank Criteria (excluding
             the "more than one affected relative" criterion).

          3. Clinically meaningful response to Levodopa (L-Dopa) with well-defined "OFF" episodes,
             as determined by the Investigator.

          4. Receiving APOKYN® of ≤ 5 mg per dose for at least 4 weeks before the Screening Visit.

          5. Receiving stable doses of L-Dopa/carbidopa (immediate or sustained release)
             administered at least 4 times per day OR Rytary™ administered 3 times per day, for at
             least 4 weeks before the Screening Visit. Adjunctive PD medication regimens must be
             maintained at a stable dose for at least 4 weeks prior to the Screening Visit with the
             exception that MAOB inhibitors must be maintained at a stable level for at least 8
             weeks prior to the Screening Visit.

          6. No planned medication change(s) or surgical intervention anticipated during the course
             of study.

          7. Patients must experience a well-defined "OFF" episode in the morning if they do not
             take their morning PD medications on schedule, and must be willing to delay morning
             doses on the 3 study dosing days

          8. Stage III or less on the modified Hoehn and Yahr scale in the "ON" state.

          9. Mini-Mental State Examination (MMSE) score > 23.

         10. If female and of childbearing potential, must agree to use one of the following
             methods of birth control:

               -  Oral contraceptive;

               -  Contraceptive patch;

               -  Barrier (diaphragm, sponge or condom) plus spermicidal preparations;

               -  Intrauterine contraceptive system;

               -  Levonorgestrel implant;

               -  Medroxyprogesterone acetate contraceptive injection;

               -  Complete abstinence from sexual intercourse;

               -  Hormonal vaginal contraceptive ring; or

               -  Surgical sterilization or partner sterile (must have documented proof).

         11. Male patients must be either surgically sterile, agree to be sexually abstinent or use
             a barrier method of birth control (e.g., condom) or maintain a monogamous relationship
             with a person who is not of child-bearing potential from first study drug
             administration until 30days after final drug administration.

         12. Willing and able to comply with scheduled visits, treatment plan, laboratory tests,
             and other study-related procedures to complete the study.

         13. Able to understand the consent form, and to provide written informed consent

        Exclusion Criteria:

          1. Atypical or secondary parkinsonism.

          2. Previous treatment with any of the following: continuous subcutaneous (s.c.)
             apomorphine infusion; or Duodopa/Duopa.

          3. Contraindications to APO-go® or APOKYN® or hypersensitivity to apomorphine
             hydrochloride or any marcrolide antibiotic or any of the ingredients APO-go® or
             APOKYN® (notably sodium metabisulfite).

          4. Female who is pregnant or lactating.

          5. Participation in a clinical trial within 30 days prior to the Screening Visit.

          6. Receipt of any investigational (ie, unapproved) medication within 30 days prior to the
             Screening Visit.

          7. Any selective 5HT3 antagonists (ie, ondansetron, granisetron, dolasetron,
             palonosetron, alosetron), dopamine antagonists (excluding quetiapine and clozapine) or
             dopamine depleting agents within 30 days prior to the Screening Visit.

          8. Drug or alcohol dependency in the past 12 months.

          9. History of malignant melanoma.

         10. Clinically significant medical, surgical, or laboratory abnormality in the opinion of
             the Investigator.

         11. Major psychiatric disorder including, but not limited to, dementia, bipolar disorder,
             psychosis, or any disorder that, in the opinion of the Investigator, requires ongoing
             treatment that would make study participation unsafe or make treatment compliance
             difficult.

         12. History of clinically significant hallucinations during the past 6 months.

         13. History of clinically significant impulse control disorder(s).

         14. Dementia that precludes providing informed consent or would interfere with
             participation in the study.

         15. Current suicidal ideation within one year prior to the Screening Visit as evidenced by
             answering "yes" to Questions 4 or 5 on the suicidal ideation portion of the
             Columbia-Suicide Severity Rating Scale (C-SSRS) or attempted suicide within the last 5
             years.

         16. Donation of blood plasma in the 30 days prior to first dosing.

         17. Cankers or mouth sores within 30 days prior to the Screening Visit, or other
             clinically significant oral pathology in the opinion of the Investigator. The
             Investigator should follow-up with an appropriate specialist on any finding, if
             indicated, before enrolling a patient into the study.