Residual Effects of Intoxication on Student Performance
Condition: Alcoholic Intoxication; Neurobehavioral Manifestations
MeSH terms: Neurobehavioral Manifestations; Alcoholic Intoxication
Intervention: Alcohol; Placebo
Intervention description: Participants report for their first dosing night where they receive several alcohol/beer drinks sufficient to raise their BrAC to 0.10 g%. Participants are breath-tested after completing their required dose. Participants return in a week for the 2nd session and receive placebo drinks. Participants are breath-tested after completing their placebo drinks.; Participants report for their first night where they receive several placebo drinks. Participants are breath-tested after completing their placebo drinks. Participants return in a week for the 2nd session and receive alcohol drinks sufficient to raise their BrAC to 0.10 g%. Participants are breath-tested after completing their required dose.
Phase: Phase 2
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Enrollment: 239.0
Sex: All
Minimum age: 21 Years
Maximum age: 30 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Alcohol abuse; Alcoholic beverages (beer); Residual effects; Psychomotor performance; Psychomotor vigilance test; Neurobehavioral Evaluation System; Family history of alcohol use; Alcoholic Consumption; Unhealthy alcohol use; Alcohol

Summary:

      The primary goal of the study is to assess the residual effects of heavy drinking on academic
      performance. The investigators will also explore whether these effects differ by family
      history of alcohol abuse and hangover symptoms, as well as compare males and females with
      respect to these effects. The primary hypothesis is that intoxication (0.10 g% blood alcohol
      concentration [BAC]) with an alcoholic beverage impairs next-day academic performance, as
      measured by scores on quizzes, standardized academic achievement tests, and standardized
      neurobehavioral assessments. The secondary hypothesis is that family-history-positive
      individuals will show a greater performance decrement the day after heavy drinking than
      family-history-negative individuals.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Ages 21-30

          -  Currently enrolled in college/university

          -  Have had 5 or more drinks (4 if female) in the last 30 days

          -  Score less than a 5 on the Short Michigan Alcohol Screening Test (SMAST)

          -  No self-reported history of counseling or treatment for substance abuse

          -  Not taking any medication contraindicated for alcohol use or that disrupts sleep

          -  Doesn't have a health condition contraindicated for alcohol use

          -  Has not been diagnosed with a primary sleep disorder

          -  Has not been diagnosed with a mental health disorder

          -  Not currently working night shifts at a job

          -  Not routinely taking medications that affect sleep

          -  If female, is using reliable birth control when necessary

          -  Not a regular smoker

          -  Likes the taste of beer

        Exclusion Criteria:

          -  Less than age 21 and greater than age 30

          -  Not currently enrolled in college/university

          -  Hasn't had 5 or more drinks (4 if female) in the last 30 days (not a regular drinker)

          -  Score greater than or equal to 5 on the Short Michigan Alcohol Screening Test (SMAST)

          -  Self-reported history of counseling or treatment for substance abuse

          -  Taking any medication contraindicated for alcohol use or that disrupts sleep

          -  Has a health condition contraindicated for alcohol use

          -  Has been diagnosed with a primary sleep disorder

          -  Has been diagnosed with a mental health disorder

          -  Currently working night shifts at a job

          -  Routinely taking medications that affect sleep

          -  Is a regular smoker

          -  Is currently pregnant or nursing

          -  If female, is not using reliable birth control when necessary

          -  Not a regular drinker

          -  Dislikes the taste of beer