A Study of Bevacizumab and Extended Treatment of Temozolomide in Patients With Recurrent Glioblastoma Multiforme
Condition: Glioblastoma Multiforme
MeSH terms: Glioblastoma
Intervention: bevacizumab [Avastin]; temozolomide
Intervention description: Bevacizumab 10 mg/kg body weight will be administered intravenously every two weeks; Daily by the oral route (dose, 150 mg/m2) on days 1 to 7 and 15 to 21 of each cycle
Intervention MeSH terms: Bevacizumab; Temozolomide
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 32.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This is a Phase II, national, multicenter, open-label, non-comparative study to investigate
      the efficacy and safety of bevacizumab and temozolomide in patients with recurrent
      glioblastoma multiforme (GBM) after a first treatment failure. Patients will receive
      bevacizumab 10 mg/kg intravenously every two weeks until disease progression, consent
      withdrawal, or unacceptable toxicity. Anticipated time on study treatment is 12-24 months.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Age >= 18 years

          -  Histological diagnosis of glioblastoma multiforme (GBM) documented by surgical
             resection or biopsy.

          -  They should be patients in a first relapse treated with radiotherapy and chemotherapy
             and chemotherapy based on temozolomide 150-200 mg/m2 on days 1 to 5 every 28 days
             (Stupp regimen) for at least three cycles. At least 4 weeks must have lapsed since
             previous chemotherapy and 3 months since the last dose of radiotherapy.

          -  Use of an effective contraceptive method by patients and their partners.

          -  Stable or decreasing corticosteroid dose for the five days prior to study entry

          -  Adequate hematological function

          -  Adequate liver function

          -  Adequate kidney function

        Exclusion Criteria:

          -  Signs of recent bleeding at the MRI of the brain. However, patients with clinically
             asymptomatic presence of hemosiderin, resolving bleeding changes related to surgery,
             and presence of punctate hemorrhage in the tumor will be allowed to participate in the
             study.

          -  Prior treatment with bevacizumab

          -  Poorly controlled arterial hypertension

          -  History of hypertensive crises or hypertensive encephalopathy

          -  New York Health Association (NYHA) Class II or higher congestive heart failure

          -  History of myocardial infarction or unstable angina pectoris within six months of
             study entry

          -  History of stroke or TIA within six months of study entry

          -  Significant vascular disease within six months of study entry

          -  History of hemoptysis > grade 2 according to the NCI CTC criteria within one month of
             study entry

          -  Evidence of bleeding diathesis or coagulopathy (in the absence of therapeutic
             anticoagulation)

          -  Major surgery, open biopsy, intracranial biopsy, ventriculoperitoneal shunt, or major
             traumatic lesion within 28 days of study entry.

          -  Core needle biopsy (excluding intracranial biopsy) or other minor surgery within seven
             days of randomization. Placement of a central vascular access device (CVAD) if
             performed in the two days prior to bevacizumab administration

          -  History of abdominal fistula or gastrointestinal perforation within six months of
             study entry

          -  History of intracranial abscess within six months of randomization

          -  Any prior malignant neoplasm treated with curative intent in the five years prior to
             study entry, except for adequately controlled limited basal cell carcinoma of the
             skin, squamous cell carcinoma of the skin, or carcinoma in situ of the cervix

          -  Patients with any other metabolic or psychological disease

          -  Hypersensitivity to products derived from Chinese hamster ovary cells or to other
             humanized or recombinant human antibodies