The Effect of Paricalcitol Capsules on Reducing Albuminuria in Patients With Type 2 Diabetic Nephropathy Being Treated With Renin-angiotensin System Inhibitors
Condition: Diabetic Nephropathy; Chronic Kidney Disease
MeSH terms: Kidney Diseases; Renal Insufficiency, Chronic; Diabetic Nephropathies; Albuminuria
Intervention: Zemplar (paricalcitol ) capsules; Zemplar (paricalcitol) capsules; Placebo
Intervention description: Group 2 - paricalcitol 1 mcg capsules once daily (one paricalcitol 1 mcg capsule once daily and one matching placebo capsule once daily); Group 3 - paricalcitol 2 mcg capsules once daily (two paricalcitol 1 mcg capsules once daily); Group 1 - Placebo once daily (two placebo capsules once daily)
Intervention MeSH terms: Ergocalciferols
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 281.0
Sex: All
Minimum age: 20 Years
Healthy volunteers: No
Keywords: Type 2 Diabetic Nephropathy

Summary:

      The study objective was to evaluate the safety of paricalcitol capsules and the efficacy of
      paricalcitol capsules for albuminuria reduction in patients with Chronic Kidney Disease (CKD)
      who have Type 2 diabetic nephropathy and are receiving optimal angiotensin converting enzyme
      (ACE) inhibitor and/or angiotensin II receptor blocker (ARB) therapy.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Male or female participant >= 20 years old.

          -  Participant has Type 2 Diabetes Mellitus and has been treated with at least one
             anti-hyperglycemic medication within the 12 months prior to the Screening Phase

          -  Participant has been receiving a stable dose (i.e., same type and regimen) of ACEi
             and/or ARB for at least three months prior to the Screening Phase. However,
             participant may have switched to different brands but at equivalent doses during the
             three months prior to the Screening Phase.

          -  Participant is not expected to begin dialysis for at least 6 months.

          -  If female, participant is not breast feeding or is not pregnant.

          -  For entry into the Treatment Phase, the participant must satisfy the following
             criteria based on the Screening laboratory values:

               -  Estimated glomerular filtration rate (GFR) between 15-90 mL/min/1.73m2 by
                  simplified Modification in Diet in Renal Disease (MDRD) formula

               -  Urinary albumin to creatinine ratio (UACR) between 100 and 3000 mg/g as
                  determined by the mean of the three first morning void urine specimens obtained
                  within one week of each other

               -  Corrected serum calcium level <= 9.8 mg/dL

               -  intact parathyroid hormone (iPTH) value between 35-500 pg/mL

               -  Glycosylated hemoglobin A1c (HbA1c) <= 12%

               -  Serum albumin > 3.0 g/dL

               -  Negative urine pregnancy test for female participants

        Exclusion Criteria:

          -  Participant has previously been on prescription-based vitamin D therapy within the six
             months prior to the Screening Phase.

          -  Participant has a history of an allergic reaction or significant sensitivity to
             paricalcitol or to drugs similar to the study drug.

          -  Participant has primary glomerulonephritis or secondary nephritis in addition to
             diabetic nephropathy.

          -  Participant has had acute renal failure within 12 weeks of the Screening Phase,
             defined as an acute rise (of >= 0.5 mg/dL) in serum creatinine to > 4 mg/dL.

          -  Participant has chronic gastrointestinal disease.

          -  Participant has secondary hypertension.

          -  Participant has poorly controlled hypertension.

          -  Participant has a history of kidney stones.

          -  Participant has a history of drug or alcohol abuse within six months prior to the
             Screening Phase.

          -  Participant has evidence of poor compliance with diet or medication.

          -  Participant has received any investigational drug within 30 days prior to study drug
             administration.

          -  Participant is taking calcitonin, bisphosphonates, cinacalcet, glucocorticoids (except
             topical glucocorticoids), or other drugs that may affect calcium, or bone metabolism,
             other than calcium containing phosphate binder or female participants on stable (same
             dose and product for three months) estrogen and/or progestin therapy.

          -  For any reason, participant is considered by the Investigator to be an unsuitable
             candidate to receive paricalcitol capsules or is put at risk by study procedures.

          -  Participant is known to be human immunodeficiency virus (HIV) positive.

          -  Participant has used known inhibitors or inducers of cytochrome P450 3A (CYP3A) within
             two weeks prior to study drug administration.