A Study of AUY922 in Non-small-cell Lung Cancer Patients Who Have Received Previous Two Lines of Chemotherapy.
Condition: Non-small-cell Lung Cancer
MeSH terms: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung
Intervention: AUY922
Intervention description: AUY922 was supplied in individual 10 mL amber colored glass ampoules containing 10 mL of a 5 mg/mL active drug substance in 5% aqueous glucose solution. AUY922 was administered intravenously (i.v.) weekly at 70 mg/m2.
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 153.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Non-small-cell lung cancer; HSP90; 2nd to 3rd line treatment

Summary:

      This study will assess the efficacy of AUY922, when administered weekly at 70 mg/m2, in adult
      patients with advanced Non-small-cell Lung Cancer (NSCLC), who have received at least two
      prior lines of chemotherapy. Patients will be retrospectively, and prospectively, stratified
      based on their molecular tumor etiology. The following strata was assigned: Patients with
      Epidermal growth factor receptor (EGFR) activating mutations, Patients with Kirstin Raus
      sarcoma virus (KRAS) activating mutations, Patients with EML4-ALK (anaplastic lymphoma
      kinase) translocations and patients that were both EGFR and Kras wild type.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Patients with histologically or cytologically confirmed advanced (stage IIIB or stage
             IV) NSCLC who have received at least two prior lines of treatment. Patients who, in
             the investigators opinion, are deemed unsuitable for the standard 2nd line
             chemotherapy will be eligible for protocol participation. One of the prior lines must
             have included a platinum agent. Prior treatment with a platinum agent is not a
             requirement for EGFR mutant patients and patients with EML4-ALK translocations

          -  Patients enrolled to the fifth stratum, modified EGFR mutant, must have documented
             prior response to EGFR TKI as defined by CR, PR or SD for 6 months or greater unless
             patient has de novo resistance to EGFR TKI (e.g. exon 20 insertions.)

          -  All patients must have at least one measurable lesion as defined by RECIST criteria.
             Previously irradiated lesions are not measurable unless the lesion is new or has
             demonstrated clear progression after radiation

          -  World Health Organization (WHO) performance status ≤ 2. For patients enrolled to the
             fifth stratum, modified EGFR mutant, World Health Organization (WHO) performance
             status ≤ 1

          -  Patients enrolled to the fifth stratum, modified EGFR mutant, must be willing and
             suitable to undergo fresh baseline biopsy prior to study treatment (unless patient had
             recent biopsy after EGFR TKI progression that concluded resistance to EGFR TKI.)

          -  Hematologic:

               -  Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L.

               -  Hemoglobin (Hgb) ≥ 9 g/dl.

               -  Platelets (plt) ≥ 100 x 109/L.

        Biochemistry:

          -  Total calcium (corrected for serum albumin) within normal limits or correctable with
             supplements.

          -  Magnesium within lower normal limits or correctable with supplements.

        Adequate liver function defined as:

          -  AST/SGOT and ALT/SGPT ≤ 3.0 x Upper limit of Normal (ULN) or ≤ 5.0 x ULN if liver
             metastasis are present.

          -  Serum bilirubin ≤ 1.5 x ULN.

          -  Serum albumin > 2.5 g/dL.

          -  Serum creatinine ≤ 1.5 x ULN or 24 hour clearance ≥ 50 mL/min.

        Exclusion Criteria:

          -  Patients who have received more than four lines of prior treatment. Exception:
             Patients enrolled to the fifth stratum, modified EGFR mutant, must not have received
             more than two prior lines of therapy. Chemotherapy administered as adjuvant treatment
             more than six months prior to study enrollment is not considered a prior line of
             therapy for purposes of this study.

          -  Patients with a history of CNS metastasis. Note: Patients without clinical signs and
             symptoms of CNS involvement are not required to have MRI of the brain. Exception:
             Patients with treated brain metastases who are asymptomatic, who has discontinued
             corticosteroids, and who have been clinically stable for one month will be eligible
             for protocol participation. This exception is not valid for patients enrolled to the
             fifth stratum, modified EGFR mutant. These patients must not have CNS involvement.

          -  Prior anti-neoplastic treatment with any HSP90 or HDAC inhibitor compound.

          -  Patients must not have received:

               -  any systemic anti-cancer treatment or radiotherapy within 4 weeks prior to first
                  dose of study treatment and should have recovered to baseline or less than Grade
                  1 from toxicities of such therapy prior to the first dose of study treatment

               -  2 weeks for palliative radiotherapy to bones, 6 weeks for nitrosoureas and
                  mitomycin

               -  4 weeks for monoclonal antibodies

               -  and ≤5 half-life of the agent or active metabolites [if any] for continuous
                  systemic anti-cancer treatment or investigational

          -  Patients who do not have either an archival tumor sample available or are unwilling to
             have a fresh tumor sample collected at baseline.

        Other protocol-defined inclusion/exclusion criteria may apply