Temsirolimus and Bevacizumab in Treating Patients With Stage III or Stage IV Malignant Melanoma
Condition: Recurrent Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma
MeSH terms: Melanoma; Skin Neoplasms
Intervention: Bevacizumab; Laboratory Biomarker Analysis; Temsirolimus; Therapeutic Conventional Surgery
Intervention description: Given IV; Correlative studies; Given IV; Undergo tumor resection
Intervention MeSH terms: Sirolimus; Bevacizumab; Antineoplastic Agents, Immunological; Temsirolimus; MTOR Inhibitors; Endothelial Growth Factors; Antibodies; Immunoglobulins; Antibodies, Monoclonal; Immunoglobulin G
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 17.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This phase II trial is studying how well giving temsirolimus together with bevacizumab works
      in treating patients with stage III or stage IV malignant melanoma. Temsirolimus may stop the
      growth of tumor cells by blocking some of the enzymes needed for their growth. Monoclonal
      antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the
      ability of tumor cells to grow and spread. Others find tumor cells and help kill them or
      carry tumor-killing substances to them. Bevacizumab may also stop the growth of malignant
      melanoma by blocking blood flow to the tumor. Giving temsirolimus together with bevacizumab
      may kill more tumor cells.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Histologically or cytologically confirmed melanoma

               -  Stage III or IV disease

                    -  Recurrent disease allowed

          -  Measurable disease defined as ≥ 1 lesion that can be accurately measured in ≥ 1
             dimension as ≥ 20 mm with conventional techniques OR ≥ 10 mm with spiral CT scan

               -  Tumor lesions in previously irradiated areas are not considered measurable
                  disease

          -  Prior brain metastases allowed provided all of the following criteria are met:

               -  No more than a total of 5 brain metastases

               -  All metastases are no more than 2.5 cm

               -  Surgically resected or have been treated with gamma-knife or stereotactic
                  radiosurgery

               -  More than 30 days since prior disease progression

               -  More than 30 days since prior steroids for managing brain metastases

                    -  Concurrent steroids for other reasons allowed provided the dose is < that
                       required for managing brain metastases

          -  Disease accessible for core needle biopsy, incisional biopsy, and/or surgical
             resection and meets one of the following criteria:

               -  One large tumor deposit ≥ 5 cm³ from which biopsies can be harvested multiple
                  times

               -  Multiple deposits that can be biopsied or excised individually on different
                  dates, measured as follows:

                    -  One lesion ≥ 5 cm^3

                    -  Two lesions ≥ 3 cm^3

                    -  Three lesions ≥ 2 cm^3

          -  ECOG performance status 0-1

          -  Weight ≥ 110 pounds (without clothes)

          -  WBC ≥ 3,000 mm³

          -  Absolute neutrophil count ≥ 1,500/mm³

          -  Platelet count ≥ 100,000/mm³

          -  Bilirubin normal

          -  AST and ALT ≤ 2.5 times upper limit of normal

          -  Creatinine normal OR creatinine clearance ≥ 60 mL/min

          -  Urine protein: creatinine ratio < 1.0 OR 24-hour urine protein < 1,000 mg

          -  Fasting cholesterol < 350 mg/dL (cholesterol medications are allowed)

          -  Fasting triglycerides < 400 mg/dL

          -  PT INR ≤ 1.5 (unless on full-dose anticoagulants)

          -  Hematocrit < 41% (for males) or < 38% (for females)

          -  None of the following within the past 4 weeks:

               -  Uncontrolled intercurrent illness

               -  Ongoing or active acute (CTCAE v.3 grade 3 or 4) infection

               -  Abdominal fistula

               -  Gastrointestinal perforation

               -  Intra-abdominal abscess

               -  Serious or nonhealing wound, ulcer, or bone fracture

          -  No psychiatric illness or social situations that would preclude study compliance

          -  No clinically significant cardiovascular disease, including the following:

               -  Cerebrovascular accident within the past 6 months

               -  Transient ischemic attack within the past 6 months

               -  Myocardial ischemia within the past 6 months

               -  Myocardial infarction within the past 6 months

               -  Other thromboembolic event within the past 6 months

               -  Unstable angina within the past 6 months

               -  Uncontrolled hypertension (i.e., hypertension despite maximal therapy)

               -  New York Heart Association class II-IV heart disease

               -  Congestive heart failure

               -  Serious cardiac arrhythmia requiring medication

               -  Clinically significant peripheral vascular disease

               -  History of stroke

               -  Artificial valve, pacemaker, or similar device

          -  No uncontrolled diabetes

               -  Hemoglobin A1c < 7%

          -  No significant traumatic injury within the past 28 days

          -  No history of allergic reactions to compounds of similar chemical or biological
             composition to temsirolimus or bevacizumab

          -  No hypersensitivity to Chinese hamster ovary cell products or other recombinant human
             antibodies (e.g., infliximab)

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective contraception during and for ≥ 6 months after
             completion of study treatment

          -  HIV negative

          -  Hepatitis C negative

          -  See Disease Characteristics

          -  More than 4 weeks since any of the following prior treatments and recovered:

               -  Chemotherapy (6 weeks for nitrosoureas or mitomycin C)

               -  Radiotherapy to nontarget lesions or lesions that are not to be biopsied

               -  Immunotherapy

               -  Cytokine therapy

               -  Enzyme-inducing antiepileptic drugs (EIAEDs) or other CYP3A4 inducers

               -  Investigational agents

          -  More than 4 weeks since prior major surgery or open biopsy and recovered

          -  No prior temsirolimus, rapamycin, bevacizumab, or systemic therapies targeted
             primarily to vascular endothelial growth factor (VEGF), VEGF receptors, or to mTOR
             inhibition

          -  Concurrent full-dose anticoagulants (e.g., warfarin/low molecular weight heparin) with
             PT INR > 1.5 are allowed provided the following criteria are met:

               -  In-range INR (usually between 2 and 3.5) on a stable dose of oral anticoagulant
                  or on a stable dose of low molecular weight heparin

               -  No active, clinically significant bleeding or pathological condition that carries
                  a high risk of bleeding (e.g., tumor involving major vessels or known varices)

                    -  Minimal tumor bleeding of the skin allowed at the clinician's discretion

          -  No concurrent medications or substances known to affect or with the potential to
             affect the activity or pharmacokinetics of the following:

               -  Temsirolimus

               -  Bevacizumab

               -  CYP450 isoenzymes

          -  No concurrent nonstudy-related surgical procedures

          -  No other concurrent anticancer agents or therapies

        Exclusion Criteria

          -  Participants who have received these medications or treatments at any time ≤ 4 weeks
             of registration:

               -  Chemotherapy

               -  Radiotherapy to non-target lesions and lesions that are not to be biopsied. Prior
                  radiotherapy to target lesions or lesions to be biopsied/resected is not
                  permitted

               -  Immunotherapy

               -  Cytokine therapy

               -  Investigational reagents

               -  Invasive procedures defined as follows:

                    -  Major surgical procedure, open biopsy or significant traumatic injury

                    -  Anticipation of need for non-study related surgical procedures from
                       registration until Cycle 26 (One year).

               -  Enzyme-inducing antiepileptic drugs (EIAEDs) or any other CYP3A4 inducer
                  (Appendix C).

        OR Participants who have not recovered from adverse events resulting from the
        administration of these agents/procedures > 4 weeks prior to registration.

          -  Participants who have received nitrosureas or mitomycin C ≤ 6 weeks of registration.

          -  History of allergic reactions attributed to compounds of similar chemical or biologic
             composition to CCI-779 or bevacizumab, or with known hypersensitivity to Chinese
             hamster ovary cell products (t-PA) or other recombinant human antibodies (e.g.,
             Remicade®).

          -  Participants who have previously received CCI-779, rapamycin, bevacizumab, or systemic
             therapies targeted primarily to VEGF, VEGF receptors, or to mTOR inhibition.

          -  Participants who have experienced any of the following ≤ 4 weeks prior to
             registration:

               -  Uncontrolled intercurrent illness

               -  Infection, CTCAE3 grade 3 or 4 (either ongoing, chronic, or active infection)

               -  Abdominal fistula

               -  Gastrointestinal perforation

               -  Intra-abdominal abscess

               -  Serious or non-healing wound

               -  Serious or non-healing ulcer

               -  Serious or non-healing bone fracture.

          -  Potential subjects with clinically significant cardiovascular disease

               -  Recent history (defined as ≤ 6 months of registration) of thromboembolic events
                  including cerebrovascular accident (CVA), transient ischemic attack (TIA),
                  myocardial ischemia, myocardial infarction (MI)

               -  Uncontrolled hypertension (hypertension despite maximal therapy)

               -  Unstable angina ≤ 6 months of registration

               -  New York Heart Association Classification of ≥ class II heart disease

               -  Congestive heart failure

               -  Serious cardiac arrhythmia requiring medication

               -  Clinically significant peripheral vascular disease

               -  Have a history of stroke

               -  Have an artificial valve, pace-maker, or similar device

          -  Psychiatric illness/social situations that would limit compliance with study
             requirements.

          -  Pregnant (positive pregnancy test) or nursing women. Both fertile men and women must
             agree to use adequate contraceptive measures during study therapy and for at least 6
             months after the completion of their participation in the study therapy.

          -  PT INR > 1.5, (unless the potential subject is on full dose anticoagulants and meet
             criteria described in Section 3.1.8).

          -  Participants with uncontrolled diabetes, defined as having a HGBA1C ≥ 7%.