Volixibat (SHP626) in the Treatment of Adults With Nonalcoholic Steatohepatitis (NASH)
Condition: Non-Alcoholic Steatohepatitis
MeSH terms: Fatty Liver; Non-alcoholic Fatty Liver Disease
Intervention: SHP626; Placebo
Intervention description: 5 mg, 10 mg, and 20 mg of SHP626 capsule by orally once daily in a double-blinded fashion; Matching placebo
Intervention MeSH terms: Volixibat
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Enrollment: 197.0
Sex: All
Minimum age: 18 Years
Maximum age: 80 Years
Healthy volunteers: No
Keywords: NAFLD activity score; ASBTi; MRI PDFF; NAS; NAFLD; liver disease; ASBT; MRI proton density fat fraction; nonalcoholic steatohepatitis; apical sodium dependent bile acid transporter inhibitor; fatty liver; NASH

Summary:

      The purpose of this study is to determine if the investigational treatment volixibat (SHP626)
      is safe, tolerable and effective in adults with nonalcoholic steatohepatitis (NASH).
    

Eligibility criteria:

        Inclusion Criteria:

          1. An understanding, ability, and willingness to fully comply with study procedures and
             restrictions.

          2. Ability to voluntarily provide written, signed, and dated (personally or via a legally
             authorized representative, as applicable) informed consent to participate in the
             study.

          3. Age 18-80 years inclusive. This inclusion criterion will only be assessed at the first
             screening visit.

          4. Male, or non-pregnant, non-lactating female, who is sexually active and who agrees to
             comply with the contraceptive requirements of the protocol, or females of
             non-childbearing potential. Males and females of child-bearing potential who are
             sexually active must agree to use acceptable contraception during the study and for 30
             days following the last dose of the investigational product (IP).

          5. Presence of greater than equals to (>=) 5 percent (%) steatosis on screening magnetic
             resonance imaging (MRI) from a centrally read radiologist performed either during the
             screening period or within 6 months prior to the first visit.

          6. Histologic confirmation of nonalcoholic steatohepatitis (NASH) without cirrhosis
             (F0-F3) from a centrally read liver biopsy performed either during the screening
             period or within 6 months prior to the first visit with a NAS of >=4 with a score of
             at least 1 in each component (steatosis, lobular inflammation, and hepatocyte
             ballooning).

        Exclusion Criteria:

          1. Presence of or history of cirrhosis or evidence of decompensated liver disease
             (example: ascites, variceal bleeding, etc.) or hepatocellular carcinoma.

          2. History or presence of other concomitant liver disease as assessed by the investigator
             or determined by laboratory findings including, but not limited to: active hepatitis B
             virus (HBV) infection (hepatitis B surface antigen [HBsAg] positive and/or hepatitis B
             virus deoxyribonucleic acid (HBVDNA) positive; subjects who are hepatitis B core
             antibody [HBcAb] positive may be eligible as long as HBsAg is negative and HBVDNA is
             non detectable), active hepatitis C virus (HCV) infection (prior exposure to HCV
             [defined as HCVAb positive] without a current or prior history of a detectable HCVRNA)
             may be eligible, alcoholic liver disease, proven autoimmune hepatitis, primary biliary
             cirrhosis (PBC), primary sclerosing cholangitis (PSC), hemochromatosis, Wilson's
             disease, alpha-1 antitrypsin deficiency, bile duct obstruction, liver primary or
             metastatic cancer.

          3. Current or recurrent disease that could affect the action, absorption, disposition, or
             laboratory assessment of the IP (including bile salt metabolism in the intestine)
             example (e.g,) uncontrolled inflammatory bowel disease, uncontrolled celiac disease,
             gastric bypass procedures (gastric lap band or gastric sleeve is acceptable), ileal or
             ileocecal resection, uncontrolled irritable bowel syndrome with predominant diarrhea,
             or history of chronic diarrhea or loose stools of any etiology.

          4. Weight change >=5% after qualifying liver biopsy and/or MRI performed. If the subject
             had a liver biopsy and/or MRI within 6 months of screening, but experienced a weight
             change of >=5% since the date of liver biopsy and/or MRI, the liver biopsy and/or MRI
             must be repeated at screening.

          5. Contraindications to MRI (e.g, claustrophobia, coronary stents, coronary implantable
             devices, girth, etc.). Stents or other devices may be allowed, at the investigator's
             discretion, if they do not interfere with the functioning of the MRI machine.

          6. Current or relevant history of physical or psychiatric illness, any medical disorder
             that may require treatment or make the subject unlikely to complete the study.

          7. Treatment with Vitamin E, thiazolidinediones (TZD), or glucagon-like peptide-1
             receptor agonists (GLP-1 RA) unless subject on a stable dose for 6 months prior to
             qualifying liver biopsy and not initiated after qualifying liver biopsy and will
             continue the same dosing regimen throughout study participation.

          8. Uncontrolled diabetes defined as HbA1c of >=9.5% within 60 days prior to enrollment.

          9. Current use of any medication (including over-the-counter, herbal, or homeopathic
             preparations) that could affect the action, absorption, or disposition of the IP, or
             clinical or laboratory assessment. (Current use is defined as use within 14 days of
             screening). Subjects currently taking insulin will not be excluded; however, they must
             be on a stable dose for at least 30 days prior to screening, or a sliding scale of
             insulin is allowed as long as the subject's HbA1c remains less than (<) 9.5%.

         10. Use of drugs, herbs or supplements historically associated with causing or worsening
             NAFLD/NASH for less than 6 months prior to liver biopsy, or initiated any time after
             liver biopsy performed, including the use of total parenteral nutrition (TPN).

         11. Serum aspartate aminotransferase (AST) greater than (>) 7 times upper limit of normal
             (ULN) at screening.

         12. Serum alanine aminotransferase (ALT) >7 times ULN at screening.

         13. Elevated serum creatinine >=2.0 milligram/deciliter (mg/dL).

         14. International normalized ratio (INR) >1.3

         15. Total bilirubin (TB) >2.0 times ULN at screening (Except for documented Gilbert's
             syndrome with bilirubin levels 20 micromole per liter (mcmol/L) to 90 mcmol/L (1.2 to
             5.3 mg/dL) and with a ratio of unconjugated/conjugated bilirubin that is
             commensurately higher).

         16. Platelet count <130 × 10^9/liter (L)

         17. Medical history of impaired hemostasis or use of anticoagulant medication (use of
             antiplatelet medications, such as low-dose, that is 81 mg, aspirin [ASA] or
             clopidogrel [Plavix] will be allowed).

         18. Uncontrolled thyroid disease.

         19. Type 1 diabetes mellitus.

         20. Known or suspected intolerance or hypersensitivity to the IP, closely-related
             compounds, or any of the stated ingredients.

         21. Known history of alcohol or other substance abuse within the last year or at any time
             during the study based on investigator's discretion. Weekly alcohol intake greater
             than 21 grams/day for males and 14 grams/day for females on average or inability to
             reliably quantify alcohol consumption based on investigator's judgment.

         22. Within 6 months of MRI and liver biopsy:

               -  Have used any IP.

               -  Have been enrolled in a clinical study (including vaccine studies) that, in the
                  investigator's opinion, may impact this Shire-sponsored study.

         23. Inability to safely obtain a liver biopsy.

         24. Females who are pregnant, planning to become pregnant, or are breastfeeding, or males
             who are planning to father a child during study participation.

         25. The anticipated need for a surgical procedure during the study that could interfere
             with the treatment.

         26. Known positivity for human immunodeficiency virus (HIV) infection.

         27. Cancer within 5 years of screening, except for basal or squamous cell carcinoma of the
             skin or in situ cervical carcinoma that has been treated with no evidence of
             recurrence.

         28. History of noncompliance with medical regimens, unreliability, mental instability or
             incompetence that could compromise the validity of informed consent or lead to
             noncompliance with the study protocol.

         29. Any other conditions or abnormalities which, in the opinion of the investigator, may
             compromise the safety of the subject, or interfere with the subject participating.

         30. Subject is currently enrolled in this study at any study site (unless the subject is
             transferring to another qualified study site with prior sponsor approval).

         31. Subjects who are employees at the unit of the investigational site that is conducting
             the study.