Weekly vs. Every 2 Week vs. Every 3 Week Administration of ABI-007 (Abraxane)/Bevacizumab Combination in Metastatic Breast Cancer
Condition: Breast Neoplasms; Neoplasm Metastasis
MeSH terms: Breast Neoplasms; Neoplasms; Neoplasm Metastasis
Intervention: ABI-007 (Abraxane); bevacizumab
Intervention description: 30 minute infusions; infusions
Intervention MeSH terms: Paclitaxel; Bevacizumab; Albumin-Bound Paclitaxel
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 208.0
Sex: Female
Minimum age: 18 Years
Healthy volunteers: No
Keywords: First Line Metastatic Breast Cancer

Summary:

      This is a multi-center, open-label, randomized Phase II study in previously untreated
      patients with metastatic breast cancer to evaluate the antitumor activity and safety of
      weekly dose-dense ABI-007 (Abraxane) compared to 2-weekly regimen vs the standard 3-weekly
      infusion. All patients will also receive concurrent bevacizumab.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Pathologically confirmed adenocarcinoma of the breast.

          -  Stage IV disease

          -  Measurable disease

          -  Patients must not be a candidate for Herceptin therapy

          -  At least 4 weeks since radiotherapy, with full recovery. The measurable disease must
             be completely outside the radiation portal or there must be pathologic proof of
             progressive disease within the radiation portal.

          -  At least 4 weeks since major surgery, with full recovery.

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0-2.

          -  Female >18 years of age.

          -  Patient has the following blood counts at Baseline:

        Absolute neutrophil count ≥ 1.5 x 10^9cells/L; platelets ≥ 100 x 10^9 cells/L; hemoglobin ≥
        9 g/dL.

          -  Patient has the following blood chemistry levels at Baseline: Aspartate transaminase
             (AST or SGOT), alanine aminotransferase (ALT or SGPT) ≤ 2.5x upper limit of normal
             range (ULN); total bilirubin ≤ ULN; creatinine ≤ 1.5 mg/dL.

          -  If female of childbearing potential, pregnancy test is negative within 72 hours of
             first dose of study drug.

          -  If fertile, the patient agrees to use an effective method to avoid pregnancy for the
             duration of the study.

          -  Informed consent has been obtained.

        Exclusion Criteria:

          -  Prior neo-adjuvant or adjuvant chemotherapy is allowed, and patients must have
             recovered from the acute toxicity of such therapies. No prior therapy for metastatic
             disease is allowed. If a taxane was part of the adjuvant regimen, at least 12 months
             should have passed from completion of taxane regimen to relapse. If a non-taxane-based
             adjuvant therapy was administered, at least 6 months should have passed from
             completion to relapse.

          -  Concurrent immunotherapy or hormonal therapy.

          -  Parenchymal brain metastases, including leptomeningeal involvement.

          -  Inadequately controlled hypertension (defined as blood pressure of > 150/100 mmHg) or
             New York Heart Association (NYHA) Grade 2 or greater congestive heart failure.

          -  Any prior history of hypertensive crisis or hypertensive encephalopathy.

          -  History of myocardial infarction or unstable angina within 6 months prior to study
             enrollment.

          -  History of stroke or transient ischemic attack within 6 months prior to study
             enrollment.

          -  Significant vascular disease (e.g., aortic aneurysm, aortic dissection).

          -  Symptomatic peripheral vascular disease.

          -  Evidence of bleeding diathesis or coagulopathy.

          -  History of abdominal fistula, gastrointestinal perforation, or intra- abdominal
             abscess within 6 months prior to study enrollment.

          -  Proteinuria at screening as demonstrated by either: - Urine protein:creatinine (UPC)
             ratio > 1.0 at screening OR - Urine dipstick for proteinuria ≥ 2+ (patients discovered
             to have ≥ 2+ proteinuria on dipstick urinalysis at baseline should undergo a 24-hour
             urine collection and must demonstrate ≤ 1g of protein in 24 hours to be eligible).

          -  Known hypersensitivity to any component of bevacizumab.

          -  Core biopsy or other minor surgical procedure, excluding placement of a vascular
             access device, within 7 days prior to first dose.

          -  Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
             prior to first dose, anticipation of need for major surgical procedure during the
             course of the study. Serious, non-healing wound, ulcer, or bone fracture. Serious
             intercurrent medical or psychiatric illness, including serious active infection.

          -  History of other malignancy within the last 5 years which could affect the diagnosis
             or assessment of breast cancer.

          -  Current, recent (within 4 weeks of the first infusion of this study), or planned
             participation in an experimental drug study.

          -  Pregnant or nursing women.

          -  Sensory neuropathy of > Grade 1 at baseline.