Study of BTK Inhibitor Zanubrutinib in Participants With Relapsed/Refractory Non-GCB Type Diffuse Large B Cell Lymphoma
Condition: Diffuse Large B-cell Lymphoma
MeSH terms: Lymphoma; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse
Intervention: Zanubrutinib
Intervention description: Administered at a dose of 160 mg BID orally.
Intervention MeSH terms: Zanubrutinib
Phase: Phase 2
Study type: Interventional
Primary purpose: Prevention
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 41.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Relapsed/refractory non-GCB type

Summary:

      Screening (up to 28 days); daily treatment until disease progression, unacceptable toxicity
      or death, withdrawal of consent, lost to follow-up, or study termination from sponsor;
      treatment (up to 2 years), safety follow-up (30 days); survival follow-up until data cutoff
      for final analysis.
    

Eligibility criteria:

        Key Inclusion Criteria:

          1. Histologically confirmed non-germinal center DLBCL, by immunohistochemistry using the
             Hans algorithm:

               1. Cluster of differentiation 10 (CD10)- and B-cell lymphoma 6 protein (BCL6)-,

               2. CD10-, BCL6+, but maximal unique match+

          2. Men and women ≥ 18 years of age.

          3. Eastern Cooperative Oncology Group performance status of 0-2.

          4. Measurable disease was defined as at least 1 lymph node > 1.5 centimeters in longest
             diameter and measurable in 2 perpendicular dimensions.

          5. All participants must have provided fresh tumor biopsy or recent tumor tissue samples
             (within 2 years of study entry [informed consent form signed]).

          6. Received at least one prior therapy for DLBCL that included anthracycline-based
             chemotherapy.

          7. Participant not eligible for or refused intensive chemotherapy and hematopoietic stem
             cell transplant.

          8. Documented failure to achieve at least partial response with, or documented disease
             progression after response to, the most recent treatment regimen.

          9. Neutrophils ≥ 1 x 10^9/liter (L) independent of growth factor support within 7 days of
             study entry.

         10. Platelets ≥ 75 x 10^9/L, independent of growth factor support or transfusion within 7
             days of study entry.

         11. Creatinine clearance of ≥ 30 milliliters/minute (as estimated by the Cockcroft-Gault
             equation or estimated glomerular filtration rate).

         12. Aspartate aminotransferase and alanine aminotransferase ≤ 2.5 x upper limit of normal
             (ULN).

         13. Bilirubin ≤ 2 x ULN (unless documented Gilbert's syndrome), then up to 5 x ULN
             allowed.

         14. Independent of erythropoietin support or transfusion within 7 days of first dose of
             study drug.

         15. International normalized ratio ≤ 1.5 and activated partial thromboplastin time ≤ 1.5 x
             ULN.

         16. Participants may be enrolled who relapsed after autologous stem cell transplant if
             they are at least 6 months after transplant, participants should have had no active
             infections (that is, fungal or viral).

         17. Females of childbearing potential must have agreed to use highly effective forms of
             birth control throughout the course of the study and at least up to 90 days after last
             dose of study drug. Highly effective forms of birth control were defined as
             abstinence, hysterectomy, bilateral oophorectomy with no menstrual bleeding for up to
             6 months, intrauterine contraception, hormonal methods such as contraceptive
             injection, oral contraceptive. Males must have undergone sterilization-vasectomy, or
             utilized a barrier method where the female partner utilized the effective forms of
             birth control noted above.

         18. Life expectancy of > 3 months.

         19. Able to provide written informed consent and could understand and comply with the
             requirements of the study.

        Key Exclusion Criteria:

          1. Current or history of central nervous system lymphoma.

          2. Prior exposure to a BTK inhibitor.

          3. Prior corticosteroids (at dosages equivalent to prednisone > 20 mg/day) given with
             anti-neoplastic intent within 7 days, prior chemotherapy, targeted therapy, or
             radiation therapy within 3 weeks, or antibody-based therapies or Chinese anti-cancer
             herbal therapies within 4 weeks of the start of study drug.

          4. Major surgery within 4 weeks of screening.

          5. Toxicity of ≥ Grade 2 from prior anti-cancer therapy (except for alopecia, absolute
             neutrophil count [ANC]) and platelets. For ANC and platelets, please follow inclusion
             criteria #9 [neutrophils] and #10 [platelets]).

          6. History of other active malignancies within 2 years of study entry, with exception of
             (1) adequately treated in-situ carcinoma of cervix; (2) localized basal cell or
             squamous cell carcinoma of skin; (3) previous malignancy confined and treated locally
             (surgery or other modality) with curative intent.

          7. Currently active clinically significant cardiovascular disease such as uncontrolled
             arrhythmia, congestive heart failure, any Class 3 or 4 cardiac disease as defined by
             the New York Heart Association Functional Classification, or history of myocardial
             infarction within 6 months of screening. Left ventricular ejection fraction is lower
             than 50% measured by echocardiography.

          8. QTcF (Fridericia's correction) > 450 milliseconds or other significant
             electrocardiogram abnormalities including second degree atrioventricular (AV) block
             Type II, or third-degree AV block.

          9. Unable to swallow capsules or disease significantly affecting gastrointestinal
             function such as malabsorption syndrome, resection of the stomach or small bowel,
             symptomatic inflammatory bowel disease, or partial or complete bowel obstruction.

         10. Uncontrolled systemic infection or infection requiring parenteral anti-microbial
             therapy.

         11. Known human immunodeficiency virus, or active hepatitis B or hepatitis C infection
             (detected positive by polymerase chain reaction).

         12. Pregnant or lactating women.

         13. Any life-threatening illness, medical condition or organ system dysfunction, which, in
             the investigator's opinion, could compromise the participant's safety, or put the
             study at risk.

         14. On medications that were strong cytochrome P450 (CYP), family 3, subfamily A (CYP3A)
             inhibitors or CYP3A inducers.

        Note: Other protocol defined Inclusion/Exclusion criteria may apply.