A Study of LY2181308 Sodium in Patients With Relapsed or Refractory Acute Myeloid Leukemia
Condition: Acute Myeloid Leukemia
MeSH terms: Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute
Intervention: LY2181308 sodium; cytarabine; idarubicin
Intervention description: 750 milligrams (mg) is administered as a 3-hour intravenous infusion on Days 1, 2, 3, 8, 15, 22 of Cycle 1 (28 days) and Days 1, 8, 15, 22 of Cycle 2 (28 days) until disease progression or unacceptable toxicity develops.; 1.5 grams per square meter (g/m²) will be administered as a 4-hour intravenous infusion on Days 3, 4, 5 of Cycle 1 (28 days) and Days 1, 2, 3 of Cycle 2 (28 days) until disease progression or unacceptable toxicity develops.; 12 milligrams per square meter (mg/m²) will be administered as a 30-minute intravenous infusion on Days 3, 4, 5 of Cycle 1 (28 days) and on Days 1, 2, 3 of Cycle 2 (28 days) until disease progression or unacceptable toxicity develops.
Intervention MeSH terms: Cytarabine; Idarubicin
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 24.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      The purpose of this study is to understand the safety profile of LY2181308 sodium
      administered in combination with idarubicin and cytarabine to patients with relapsed or
      refractory acute myeloid leukemia (AML).
    

Eligibility criteria:

        Inclusion Criteria:

          -  Patients who have a diagnosis of acute myeloid leukemia that is relapsed or refractory
             to at least 1 prior treatment for leukemia, or patients with chronic myeloid leukemia
             (CML) who are in myeloid blast crisis which have failed at least 1 previous tyrosine
             kinase inhibitor (TK1). A baseline bone marrow assessment is required less than or
             equal to 96 hours prior to the first dose of study drug.

          -  Must have discontinued all previous therapies for cancer, including chemotherapy,
             radiotherapy, immunotherapy, cancer related hormone therapy, or other investigational
             therapy for at least 21 days for myelosuppressive agents (such as cytarabine,
             daunorubicin, and gemtuzumab ozogamicin) or 14 days for non-myelosuppressive agents
             prior to receiving study drug, and recovered from the acute effects of therapy (such
             as neurotoxicity, diarrhea, and mucositis) except for residual myelosuppression and
             alopecia. Hydroxyurea is permitted to control the peripheral blast cell count, but
             must be stopped at least 24 hours before study drug administration.

          -  Must have adequate organ function.

          -  Females must have a negative pregnancy test. Male and female patients must agree to
             use a reliable method of birth control during and for 6 months following the last dose
             of study drug.

          -  Patients must be at least 18 years old.

        Exclusion Criteria:

          -  Have received treatment within the last 30 days with a drug that has not received
             regulatory approval for any indication within 14 or 21 days of the initial dose of
             study drug for a non-myelosuppressive or myelosuppressive agent, respectively.

          -  Patients with acute promyelocytic leukemia (APML).

          -  Major surgery within 4 weeks of study enrollment.

          -  Patients with serious pre-existing medical conditions (at the discretion of the
             investigator). Because of the known cardiac toxicity of anthracyclines, patients with
             pre-existing ejection fraction (EF) less than or equal to 45% should not participate
             in this study. No patient should exceed the maximum exposure of anthracycline doses
             (for example, idarubicin greater than 120 mg/m²).

          -  Patients with a second malignancy that could affect the interpretation of the results.

          -  Patients with leukemic involvement of the central nervous system (CNS) by spinal fluid
             cytology or imaging.

          -  Patients with known coagulopathy or bleeding disorder, other than leukemia related
             thrombocytopenia. Patients with severe of life threatening bleeding refractory to
             platelet transfusions are also excluded.

          -  Concomitant anticoagulant therapy (with the exception of heparinized saline to
             maintain the patency of central venous catheters).

          -  Women who are pregnant or breast feeding.

          -  Patients with a known hypersensitivity to oligonucleotides, idarubicin, and/or
             cytarabine.