Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia (ADVANCE)
Condition: Schizophrenia
MeSH terms: Schizophrenia
Intervention: Pimavanserin; Placebo
Intervention description: Pimavanserin 34 mg, 20 mg, or 10 mg, taken as two tablets, once daily by mouth; Placebo, taken as two tablets, once daily by mouth
Intervention MeSH terms: Pimavanserin
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 403.0
Sex: All
Minimum age: 18 Years
Maximum age: 55 Years
Healthy volunteers: No

Summary:

      To evaluate the efficacy and safety of adjunctive pimavanserin compared with adjunctive
      placebo in the treatment of the negative symptoms of schizophrenia
    

Eligibility criteria:

        Inclusion Criteria:

          1. Adult patients, between 18 and 55 years of age

          2. A clinical diagnosis of schizophrenia with a minimum duration of 1 year

          3. Has predominant negative symptoms according to predefined study criteria

          4. The main background antipsychotic with which the subject is being treated must be one
             of the antipsychotics listed below:

               -  Aripiprazole

               -  Aripiprazole long-acting injectables:

                    -  Abilify Maintena®

                    -  Aristada®

               -  Risperidone

               -  Risperidone long-acting injection

               -  Olanzapine

               -  Lurasidone

               -  Cariprazine

               -  Brexpiprazole

               -  Asenapine

        Exclusion Criteria:

          1. Patient has a psychiatric disorder other than schizophrenia

          2. A urine drug screen (UDS) result at Baseline that indicates the presence of any tested
             prohibited substance of potential abuse, except marijuana

             a. Patients with a result indicating the presence of marijuana are permitted if they
             agree to abstain from marijuana use during the study and the medical monitor approves
             the subject's participation

          3. Patient has current evidence of a serious and/or unstable psychiatric, neurologic,
             cardiovascular, respiratory, gastrointestinal, renal, hepatic, hematologic, or other
             medical disorder, including cancer or malignancies, which would affect the patient's
             ability to participate in the program

          4. Patient has had a myocardial infarction in the last six months

          5. Patient has a family or personal history or symptoms of long QT syndrome

          6. Patient has been hospitalized due to inadequate family support or care at the
             patient's primary residence, during the 8 weeks prior to screening

        Patients will be evaluated at screening to ensure that all criteria for study participation
        are met. Patients may be excluded from the study based on these assessments (and
        specifically if it is determined that their baseline health and psychiatric condition do
        not meet all pre-specified entry criteria).