Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies
Condition: Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; B-cell Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Graft Versus Host Disease; Intraocular Lymphoma; Myelodysplastic Syndrome With Isolated Del(5q); Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Post-transplant Lymphoproliferative Disorder; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Ringed Sideroblasts; Refractory Chronic Lymphocytic Leukemia; Refractory Cytopenia With Multilineage Dysplasia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Central Nervous System Hodgkin Lymphoma; Secondary Central Nervous System Non-Hodgkin Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia
MeSH terms: Burkitt Lymphoma; Lymphoma; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Neoplasm Metastasis; Lymphoma, B-Cell; Leukemia, Lymphoid; Leukemia, Lymphocytic, Chronic, B-Cell; Hodgkin Disease; Lymphoma, Mantle-Cell; Lymphoma, B-Cell, Marginal Zone; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Immunoblastic; Plasmablastic Lymphoma; Waldenstrom Macroglobulinemia; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Hairy Cell; Leukemia, Myeloid, Chronic-Phase; Lymphomatoid Granulomatosis; Leukemia, Myeloid, Accelerated Phase; Lymphoma, Extranodal NK-T-Cell; Intraocular Lymphoma; Anemia; Myelodysplastic Syndromes; Myeloproliferative Disorders; Anemia, Refractory; Lymphoproliferative Disorders; Myelodysplastic-Myeloproliferative Diseases; Anemia, Refractory, with Excess of Blasts; Graft vs Host Disease; Recurrence
Intervention: vorinostat; tacrolimus; cyclosporine; methotrexate; laboratory biomarker analysis; pharmacological study
Intervention description: Given PO; Given IV or PO; Given IV or PO; Given IV; Correlative studies; Correlative studies
Intervention MeSH terms: Cyclosporine; Methotrexate; Vorinostat; Tacrolimus; Cyclosporins
Phase: Phase 2
Study type: Interventional
Primary purpose: Supportive Care
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 12.0
Sex: All
Minimum age: 18 Years
Maximum age: 75 Years
Healthy volunteers: No

Summary:

      This pilot phase II trial studies how well giving vorinostat, tacrolimus, and methotrexate
      works in preventing graft-versus-host disease (GVHD) after stem cell transplant in patients
      with hematological malignancies. Vorinostat, tacrolimus, and methotrexate may be an effective
      treatment for GVHD caused by a bone marrow transplant.
    

Eligibility criteria:

        Inclusion Criteria:

          -  A prospective patient for allogeneic HSCT for hematologic conditions, both malignant
             and non-malignant; donor can be unrelated marrow or peripheral blood cells; a patient
             with history of central nervous system (CNS) involvement is eligible if CNS disease is
             in remission at time of study consideration

          -  The donor and recipient must have a human leukocyte antigen (HLA)-8/8 allelic match at
             the HLA-A, -B, -C, and -DRB1; high-resolution typing is required for all alleles

          -  Diagnoses to be included:

          -  Acute myelogenous leukemia at the following stages:

               -  First remission

               -  Second or subsequent remission

               -  Complete remission is defined as the absence of blasts in the peripheral
                  circulation at the time of enrollment and < 5% blasts in the bone marrow

          -  Chronic myelogenous leukemia at the following stages:

               -  First or subsequent chronic phase:

                    -  Patient refused tyrosine kinase therapy or is otherwise not suited for it

                    -  Stable, not hematologic remission: blasts present in marrow and/or
                       peripheral blood, but disease does not qualify as accelerated or blast phase

                    -  Hematologic remission: no blast cells or precursor cells in the blood or
                       marrow

                    -  Partial cytogenetic remission: Philadelphia chromosome positive (Ph+)
                       metaphases > 0% but < 35%

                    -  Complete cytogenetic remission: absence of Ph+ metaphases

               -  Accelerated phase - any one of the following symptoms:

                    -  White blood cells (WBC) difficult to control (> 50 x 10^9/L despite therapy)

                    -  Rapid doubling of WBC (< 5 days)

                    -  10% blasts in blood or marrow

                    -  20% blasts and/or promyelocytes in blood or marrow

                    -  20% basophils and/or eosinophils in blood

                    -  Anemia or thrombocytopenia unresponsive to standard treatment

                    -  Persistent thrombocytosis (> 1000 x 10^9/L)

                    -  Cytogenetic abnormalities in addition to Ph+

                    -  Increasing splenomegaly

                    -  Marrow fibrosis

          -  Myelodysplastic syndromes at any of the following stages:

               -  Refractory anemia

               -  Refractory anemia with ringed sideroblasts

               -  Refractory cytopenia with multilineage dysplasia

               -  Refractory cytopenia with multilineage dysplasia and ringed sideroblasts

               -  Refractory anemia with excess blasts-1 (5-10% blasts)

               -  Refractory anemia with excess blasts-2 (10-20% blasts)

               -  Myelodysplastic syndrome, unclassified

               -  Myelodysplastic syndrome (MDS) associated with isolated del (5q)

               -  Chronic myelomonocytic leukemia

          -  Primary Myelofibrosis

               -  Intermediate-2 risk or high risk disease

               -  Patients should have extinguished standard of care options prior to being
                  considered for this trial

          -  Chronic lymphocytic leukemia

               -  Complete remission: the disease is completely absent and no relapse occurred
                  prior to the preparative regimen; requires all of the following:

                    -  Nodular partial remission: complete response with persistent lymphoid
                       nodules in bone marrow

                    -  Partial remission: reduction of more than 50% in the disease burden
                       regardless of the number of lines of therapy received

          -  Mature B cell malignancies

               -  Patients should have extinguished standard of care options prior to being
                  considered eligible for this trial

               -  First complete remission (CR1) confirmed: complete disappearance of all known
                  disease; the term "confirmed" is defined as a laboratory and/or pathological or
                  radiographic determination.

               -  CR1 unconfirmed (CRU1): complete disappearance of all known disease with the
                  exception of persistent scan abnormalities of unknown significance; the term
                  "unconfirmed" is defined as scan abnormalities of unknown significance that are
                  not biopsied or otherwise evaluated

               -  Second or subsequent complete remission (CR2+) confirmed: the recipient relapsed,
                  then achieved complete absence of disease without radiographic evidence of
                  disease

               -  CR2+ unconfirmed: the recipient has achieved a second or subsequent complete
                  response but has persistent radiographic abnormalities of unknown significance.

               -  Partial remission: reductions of >= 50% in greatest diameter of all sites of
                  known disease and no new sites

          -  Karnofsky >= 70%

          -  Life expectancy of greater than 6 months

          -  Total bilirubin =< 2.5 mg% (unless from Gilbert's disease or disease-related)

          -  Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
             [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
             < 3.0 X institutional upper limit of normal

          -  Estimated or actual glomerular filtration rate (GFR) > 50 mL/min/1.73 m^2 for patients
             with creatinine levels above institutional normal; GFR should be corrected for body
             surface area (BSA)

          -  Diffusing capacity of the lung for carbon monoxide (DLCO) > 50%; DLCO should be
             corrected for hemoglobin

          -  Forced expiratory volume in 1 second (FEV1) > 50%

          -  Forced vital capacity (FVC) > 50%

          -  Ejection fraction >= 50%

          -  The effects of vorinostat on the developing human fetus are unknown; for this reason
             and because histone deacetylase inhibitor agents as well as other therapeutic agents
             used in this trial (e.g., tacrolimus and methotrexate) are known to be teratogenic,
             women of child-bearing potential and men must agree to use adequate contraception
             (hormonal or barrier method of birth control; abstinence) prior to study entry and for
             the duration of study participation; should a woman become pregnant or suspect she is
             pregnant while she or her partner is participating in this study, she should inform
             her treating physician immediately; men treated or enrolled on this protocol must also
             agree to use adequate contraception prior to the study, for the duration of study
             participation, and 4 months after completion of vorinostat administration

          -  Ability to understand and the willingness to sign a written informed consent document

          -  Patients must be able to swallow capsules/tablets

        Exclusion Criteria:

          -  Patients who are not a candidate for an unrelated donor allogeneic HSCT based on the
             current institutional bone marrow transplant (BMT) program clinical practice
             guidelines; organ function criteria will be utilized per the current institutional BMT
             program clinical practice guidelines; there will be no restriction to study entry
             based on hematological parameters

          -  History of allergic reactions attributed to compounds of similar chemical or biologic
             composition to vorinostat

          -  Patients undergoing a total body irradiation (TBI)-based conditioning regimen (TBI
             1200 centigray [cGy])

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
             arrhythmia, or psychiatric illness/social situations that would limit compliance with
             study requirements; patients still under therapy for presumed or proven infection are
             eligible provided there is clear evidence (radiographic findings and/or culture
             results) that the infection is well-controlled; patients under treatment for infection
             will be enrolled only after clearance from the Principal Investigator (PI)

          -  Pregnant women are excluded from this study because vorinostat is a histone
             deacetylase inhibitor agent with the potential for teratogenic or abortifacient
             effects; because there is an unknown but potential risk for adverse events in nursing
             infants secondary to treatment of the mother with vorinostat, breastfeeding should be
             discontinued if the mother is treated with vorinostat

          -  Patients with evidence of human immunodeficiency virus (HIV) seropositivity and/or
             positive polymerase chain reaction (PCR) assay, human T-lymphotropic virus
             (HTLV)1/HTLV2 seropositivity; the safety of allogeneic HSCT is not yet
             well-established for this population

          -  Patients with evidence of hepatitis B or hepatitis C PCR positivity; hepatitis
             reactivation following myelosuppressive therapy can lead to fatal complications

          -  Patients with a history of prolonged corrected QT interval (QTc) syndrome

          -  Patients asking or who have had prior treatment with a drug like vorinostat (i.e.,
             valproic acid) within the last 30 days