Topical Roflumilast in Adults With Atopic Dermatitis
Condition: Atopic Dermatitis
MeSH terms: Dermatitis, Atopic; Dermatitis; Eczema
Intervention: 0.5% Roflumilast Cream; Vehicle Cream
Intervention description: Roflumilast 0.5% cream; Roflumilast formulation vehicle
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 40.0
Sex: All
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: No
Keywords: Atopic dermatitis

Summary:

      The purpose of this study is to evaluate the effect of topical roflumilast on the reduction
      of atopic dermatitis lesions in adults with atopic dermatitis.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Is male or female between 18 to 65 years of age, inclusive, with atopic dermatitis
             (AD) meeting Hanifin and Rajka's criteria.

          2. Has lesional skin areas of moderate severity characterized by modified local SCORing
             Atopic Dermatitis (SCORAD) of at least 4, with an erythema score ≥2, and confirmed by
             a qualified investigator.

          3. Has an index/target lesion of moderate severity approximately 20 cm^2, suitable for
             topical treatment.

          4. Is willing to wash out from AD current active therapy prior to entry in the study.

          5. Is willing and able to apply the study medication as directed, comply with study
             instructions and commit to all follow-up visits for the duration of the study.

          6. If a male who is nonsterilized and sexually active with a female partner of
             childbearing potential, agrees to use adequate contraception from signing of informed
             consent throughout the duration of the study and for 12 weeks after last dose.

          7. If a female of childbearing potential who is sexually active with a nonsterilized male
             partner, agrees to use routinely adequate contraception from signing of informed
             consent throughout the duration of the study and for 12 weeks after last dose.

          8. Is capable of understanding and complying with protocol requirements in the opinion of
             the investigator.

          9. Signs and dates a written informed consent form and any required privacy authorization
             prior to the initiation of any study procedures.

        Exclusion Criteria:

          1. Has received any investigational compound within 30 days, or within 5 half-lives of
             the compound (whichever is longer) prior to the Screening visit.

          2. Has a history of AD unresponsive or poorly responsive to topical treatments.

          3. Has a history of hypersensitivity to phosphodiesterase (PDE)-4 inhibitors or to drugs
             of similar chemical classes or any inactive ingredients of the trial medication.

          4. Has clinically significant abnormal hematological parameters of hemoglobin, hematocrit
             or erythrocytes at Screening, in the judgment of the investigator.

          5. Has a history or current clinically relevant allergy or idiosyncrasy to drugs or food.

          6. Had extensive exposure to ultraviolet (UV) light in the 4 weeks prior to first
             application of study medication, including tanning and sun beds or is intending to
             have such exposure during the study treatment that may interfere with the study
             assessments as judged by the investigator.

          7. Has evidence of oozing of target lesion.

          8. Has a current skin complication such as erythroderma or overt bacterial or viral
             infection for which treatment with anti-infectives are indicated.

          9. Had systemic treatment with corticosteroids or retinoids for studied condition within
             3 months prior to the first application of study medication.

         10. Had topical or transdermal treatments, such as but not limited to retinoids, nicotine
             or hormone replacement therapies, on or near the intended site of application within 4
             weeks prior to first application of study medication.

         11. Had treatment with systemic/locally acting medications/procedures that might counter
             or influence the study aim within 4 weeks prior to first application of study
             medication and during the study (e.g., anti-histamines).

         12. Has used emollients/moisturizers on areas to be treated within 24 hours prior to the
             first application of study medication.

         13. Has used biologics at any time for treatment of AD.

         14. Is currently enrolled in an investigational drug or device study.

         15. Has any clinically significant illness that may influence the outcome of the trial
             from 4 weeks before Day 1 through trial completion.

         16. Has alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) values
             greater than 2.0 × upper limit of normal (ULN), or other clinically significant
             abnormal laboratory test that, in the opinion of the Investigator, would compromise
             the participant's ability to safely complete the trial.

         17. Has a significant medical condition and/or conditions that, in the opinion of the
             Investigator, would interfere with the treatment, safety or compliance with the
             protocol.

         18. Has a history of infection with hepatitis B, hepatitis C, or human immunodeficiency
             virus.

         19. Has a history of alcoholism or illicit drug abuse within 5 years prior to the
             Screening Visit or is currently consuming >14 alcoholic drinks per week.

         20. If female, is pregnant, nursing or planning a pregnancy during the study period.

         21. Has a history of cancer that has not been in remission for at least 5 years prior to
             the first dose of study medication. This criterion does not apply to those
             participants with successfully resected basal cell or stage I squamous cell carcinoma
             of the skin.

         22. Has a chronic or clinically relevant acute infection.

         23. Has a history of depression associated with suicidal ideation and behavior.

         24. Has hemodynamically significant cardiac arrhythmias or heart valve deformations.

         25. Is an immediate family member, a study site employee, in a dependent relationship with
             a study site employee who is involved in conduct of this study (e.g., spouse, parent,
             child, sibling) or at risk for consenting under duress.

         26. Was institutionalized because of a legal or regulatory order.