TPIV200/huFR-1 (A Multi-Epitope Anti-Folate Receptor Vaccine) Plus Anti-PD-L1 MEDI4736 (Durvalumab) in Patients With Platinum Resistant Ovarian Cancer
Condition: Ovarian Cancer
MeSH terms: Ovarian Neoplasms; Carcinoma, Ovarian Epithelial
Intervention: TPIV200; Durvalumab
Intervention MeSH terms: Durvalumab
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 29.0
Sex: Female
Minimum age: 18 Years
Healthy volunteers: No
Keywords: TPIV200/huFR-1; Anti-PD-L1; vaccine; 16-011

Summary:

      This is a Phase 2 clinical trial, which tests two investigational drugs: TPIV200/huFR-1 (also
      called TPIV200), which is a vaccine consisting of proteins from the folate receptor alpha
      mixed with GM-CSF, and durvalumab (MEDI4736) , which is an antibody drug that help un-block
      parts of the immune system. The aim of this study is to find out whether these drugs, when
      given together are safe, and whether they are effective in treating cancer.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Subjects must have recurrent or persistent platinum-resistant epithelial ovarian,
             fallopian tube, or primary peritoneal carcinoma with measureable disease (as defined
             by RECIST 1.1.) who have received at least one prior platinum-based therapy.

        Platinum-based therapy is defined as treatment with carboplatin, cisplatin or another
        organoplatinum compound.

        Platinum-resistant is defined as having had disease progression within 6 months or most
        recent platinum therapy, or having disease progression while receiving previous
        platinum-based chemotherapy.

        Histologic documentation of diagnosis of carcinoma is required and the following histologic
        subtypes are eligible: high grade serous, clear cell, endometrioid, carcinoma,
        adenocarcinoma, mixed (including above subtypes only).

          -  Age ≥ 18 years

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

          -  Resolution of (non-laboratory) adverse effects of recent surgery, radiotherapy, or
             chemotherapy to Grade ≤1 prior to first study treatment (with the exception of
             alopecia or neuropathy; chemotherapy-induced peripheral neuropathy up to Grade ≤2 will
             be permitted)

          -  Patients must have measurable disease. Measurable disease is defined by RECIST
             (version 1.1). Measurable disease is defined as at least one lesion that can be
             accurately measured in at least one dimension (longest diameter to be recorded) and
             has not been previously irradiated. Each lesion must be ≥ 10 mm when measured by CT,
             MRI or caliper measurement by clinical exam; or ≥ 20 mm when measured by chest x-ray.
             Lymph nodes must be ≥ 15 mm in short axis when measured by CT or MRI.

          -  Adequate normal organ and marrow function defined by the following laboratory results
             obtained within 14 days prior to first treatment:

               -  Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L (> 1500 per mm3)

               -  Platelet ≥ 100 x 10^9/L (>100,000 per mm3)

               -  Hemoglobin ≥ 9.0 g/dL

               -  Serum bilirubin ≤ 1.5 x institutional upper limit of normal (ULN). (Unless
                  Gilbert's Syndrome, without concurrent clinically significant liver disease)

               -  AST (SGOT)/ALT (SGPT) ≤ 2.5 x institutional upper limit of normal unless liver
                  metastases are present, in which case it must be ≤ 5x ULN

               -  Serum creatinine CL>40 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault
                  1976) or by 24-hour urine collection for determination of creatinine clearance:

        Creatinine CL = Weight (kg) x (140 - Age) x 0.85 (mL/min) 72 x serum creatinine (mg/dL)

          -  Female subjects must either be of non-reproductive potential (ie, post-menopausal by
             history: ≥60 years old and no menses for ≥1 year without an alternative medical cause;
             OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of
             bilateral oophorectomy) or must have a negative serum pregnancy test upon study entry.

          -  Subject is willing and able to comply with the protocol for the duration of the study
             including undergoing treatment and scheduled visits and examinations including follow
             up.

        Exclusion Criteria:

          -  Involvement in the planning and/or conduct of the study (applies to both AstraZeneca
             staff and/or staff at the study site); Previous enrollment in the present study.

          -  Participation in another clinical study with receipt of an investigational product
             during the last 4 weeks

          -  Any previous treatment with a PD-1 or PD-L1 inhibitor, including durvalumab

          -  History of another primary malignancy except for:

               -  Malignancy treated with curative intent and with no known active disease ≥3 years
                  before the first dose of study drug and of low potential risk for recurrence

               -  Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
                  of disease

               -  Adequately treated carcinoma in situ without evidence of disease (eg, cervical
                  cancer in situ)

               -  Adequately treated stage 1 breast or stage 1 low grade endometrial cancer

          -  Receipt of the last dose of anti-cancer therapy (chemotherapy, immunotherapy,
             endocrine therapy, targeted therapy, biologic therapy, tumor embolization, monoclonal
             antibodies, other investigational agent) < 21 days prior to the first dose of study
             drug.

          -  Mean QT interval corrected for heart rate (QTc) >/= 470 ms calculated from 3
             electrocardiograms (ECGs) using Fridericia's Correction

          -  Current or prior use of immunosuppressive medication within 28 days before the first
             dose of durvalumab, with the exceptions of intranasal and inhaled corticosteroids or
             systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of
             prednisone, or an equivalent corticosteroid. Steroid pre-medication for CT scan
             contrast or study drug, is allowable, regardless of dose.

          -  Any prior Grade >/= 3 immune-related adverse event (irAE) while receiving any previous
             immunotherapy agent, or any unresolved irAE > Grade 1

          -  Active or prior documented autoimmune disease within the past 2 years NOTE: Subjects
             with vitiligo, Grave's disease, or psoriasis not requiring systemic treatment (within
             the past 2 years) are not excluded.

          -  Active or prior documented inflammatory bowel disease (e.g., Crohn's disease,
             ulcerative colitis)

          -  History of primary immunodeficiency

          -  History of allogeneic organ transplant

          -  History of hypersensitivity to durvalumab or any excipient

          -  History of hypersensitivity to TPIV200

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable
             angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis, active
             bleeding diatheses including any subject known to have evidence of acute or chronic
             hepatitis B, hepatitis C or human immunodeficiency virus (HIV), or psychiatric
             illness/social situations that would limit compliance with study requirements or
             compromise the ability of the subject to give written informed consent

          -  Known history of previous clinical diagnosis of tuberculosis

          -  Receipt of live attenuated vaccination within 30 days prior to study entry or within
             30 days of receiving durvalumab

          -  Subjects who are pregnant, breast-feeding or of reproductive potential who are not
             employing an effective method of birth control

          -  Any condition that, in the opinion of the investigator, would interfere with
             evaluation of study treatment or interpretation of patient safety or study results

          -  Any condition that, in the opinion of the investigator, would interfere with
             evaluation of study treatment or interpretation of patient safety or study results

          -  Subjects with uncontrolled seizures

          -  Known hypersensitivity reaction to the GM-CSF adjuvant

          -  Patients who have developed any evidence of clinical or radiologic pneumonitis,
             COP/BOOP, or other lung injury, during treatment with prior FRα-targeting therapy,
             such as mirvetuximab soravtansine (IMGN853), or with any prior cancer immunotherapy.