Evaluation of Pharmacodynamic Effects on Ovulation and Cycle Control
Condition: Ovulation Suppression
MeSH terms: Vision Disorders
Intervention: levonorgestrel and ethinyl estradiol
Intervention description: pregnancy prevention
Intervention MeSH terms: Levonorgestrel; Ethinyl Estradiol; Ethinyl estradiol, levonorgestrel drug combination; Estradiol
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 123.0
Sex: Female
Minimum age: 18 Years
Maximum age: 45 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: contraception; pregnancy prevention

Summary:

      Evaluate the adequacy of ovulation suppression, cycle control, and safety of three
      transdermal contraceptive delivery systems (TCDSs).
    

Eligibility criteria:

        Inclusion Criteria:

          1. Healthy adult women, ages 18-45.

          2. Cycles with a usual duration between 21 and 35 days and an individual variation of +/
             3 days.

          3. Normotensive (blood pressure < 140/90 mm Hg at rest) at screening and randomization
             visits (Visits 1 and 2).

          4. Willing to use a non-hormonal method of contraception for the entire duration of the
             study, or

          5. Have already undergone previous bilateral tubal ligation OR vasectomized partner OR
             not at risk of pregnancy.

          6. Willing to refrain from excessive use of alcohol during the entire duration of the
             study.

          7. Willing to give informed consent to participate in the study.

        Exclusion Criteria:

          1. History of significant medical illness or seizures.

          2. Positive hepatitis B or C antibody or positive human immunodeficiency virus (HIV)
             antibody.

          3. Known or suspected pregnancy.

          4. A recent abnormal cervical smear - low-grade squamous intraepithelial lesion (SIL) or
             higher in the Bethesda System - which has not been resolved or treated.

          5. Any disorder that contraindicates the use of contraceptive steroids i.e., history of
             heart attack and stroke, blood clots in the legs, lungs or eyes, history of blood
             clots in the deep veins of the legs, known or suspected breast cancer, hepatitis or
             yellowing of the whites of the eyes or the skin (jaundice) during pregnancy or during
             previous use of hormonal contraceptives, headaches with neurological symptoms, disease
             of heart valves with complications.

          6. Uncontrolled thyroid disorder.

          7. History of or existing thromboembolic disorder, vascular disease, cerebral vascular,
             or coronary artery disease.

          8. Undiagnosed abnormal genital bleeding.

          9. Known or suspected breast carcinoma, endometrial carcinoma, or estrogen-dependent
             neoplasia.

         10. History or presence of dermal hypersensitivity in response to topical application.

         11. Use of an injectable hormonal contraceptive (e.g. Depo-Provera®) within 6 months prior
             to Day 1.

         12. Use of a contraceptive implant (e.g. Implanon® or Jadelle®) or hormone-medicated
             intrauterine device within 2 months (60 days) prior to Day 1.

         13. Use of OCs or other sex steroid hormones within 60 days prior to Day 1.

         14. Women who are breast-feeding or are within 2 months of stopping breast-feeding.

         15. Status post-partum or post-abortion within a period of 2 months prior to Day 1.

         16. Chronic use of any medication that might interfere with the metabolism of hormone
             contraceptives (e.g., rifampin, barbiturates, phenytoin, primidone, topiramate,
             carbamazepine, phenylbutazone, ritonavir, modafinil, St John's Wort etc.) or use
             within the past 3 months prior to Day 1.

         17. Administration of investigational drug within 30 days prior to Day 1.

         18. A history (within prior 12 months) of drug or alcohol abuse.

         19. Women who smoke more than 4-5 cigarettes daily.

         20. History of skin sensitivity to adhesives.

         21. Use of over-the-counter medications or herbals that might interfere with the
             metabolism of hormone contraceptives within 3 days prior to wearing the first patch.