Study to Test GSK256073 in Patients With Dyslipidemia
Condition: Dyslipidaemias; Dyslipidemias
MeSH terms: Dyslipidemias
Intervention: GSK256073; GSK256073; GSK256073; Placebo; Niaspan; GSK256073; GSK256073
Intervention description: 5 mg for 8 weeks; 50 mg for 8 weeks; 150 mg for 8 weeks; placebo for 8 weeks; 1500 mg for 8 weeks; x mg for 8 weeks based from data from Part A; optional dose based on data from Part A
Intervention MeSH terms: Niacin; Nicotinic Acids
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Enrollment: 80.0
Sex: All
Minimum age: 18 Years
Maximum age: 75 Years
Healthy volunteers: No
Keywords: lipids; HM74A

Summary:

      This is a two part study (Part A and Part B) that will first aim to establish the PK/PD
      relationship between exposure and lipid effects (Part A: 75 subjects), and will then confirm
      the effect using the most relevant dose(s) (Part B: ~90 subjects). Doses of 5mg, 50mg and
      150mg of GSK256073 will be administered in Part A, and the dose(s) for Part B will be based
      on the PK/PD data from Part A. Data from Part A and Part B will be combined to decrease
      overall subject numbers needed in part B. Part B of the study will include a niaspan arm for
      relative comparison of the effects of GSK256073 and niacin on lipids and flushing
    

Eligibility criteria:

        Inclusion Criteria:

          -  Signed written informed consent prior to beginning study-related procedures. Subjects
             must understand the aims, investigational procedures and possible consequences of the
             study and must be able to understand and comply with protocol requirements,
             instructions and protocol-stated restrictions.

          -  Male or female 18-75 years of age at screening.

          -  A female subject is eligible to participate if she is of non-childbearing potential
             defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or
             postmenopausal defined as 12 months of spontaneous amenorrhea.

          -  Male subjects must agree to use one of several pre-specified contraception methods.
             This criterion must be followed from the time of the first dose of study medication
             until three days following the last dose.

          -  Body weight > 50 kg (110 pounds) and body mass index (BMI) between 19 and 39
             (inclusive)

          -  LDLc concentration ≥100 mg/dL at screening and within 4 weeks of randomization (if
             screening occurs > 4 weeks prior to randomization)

          -  Fasting triglyceride concentration ≤ 300 mg/dL at screening and within 4 weeks of
             randomization (if screening occurs > 4 weeks prior to randomization)

          -  HDLc ≤ 45 mg/dL for males or ≤ 55 mg/dL for females at screening and within 4 weeks of
             randomization (if screening occurs > 4 weeks prior to randomization)

          -  Subject currently receiving lipid-modifying medication(s) must agree to stop
             medication(s) for at least 6 weeks prior to randomization. After this washout period
             LDL, TG and HDL values must be remeasured and meet the above criteria prior to
             randomization in the study

          -  AST and ALT < 2xULN; alkaline phosphatase and bilirubin ≤ 1.5xULN (isolated bilirubin
             >1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35%).

        Exclusion Criteria:

          -  Evidence of clinical instability based on a medical evaluation including medical
             history, physical examination, laboratory tests and cardiac monitoring. A subject with
             a clinical abnormality or laboratory parameter outside the reference range for the
             population being studied may be included only if the Investigator and the GSK Medical
             Monitor agree that the finding is unlikely to introduce additional risk and will not
             interfere with the study procedures.

          -  Any change in concomitant medication (including multivitamins, herbal remedies,
             dietary supplements, and over-the-counter medication) within six weeks prior to
             screening that is not approved by GSK.

          -  Any change in diet, exercise habits or smoking status within six weeks prior to
             screening.

          -  A medical history significant for the following:

          -  Clinical cardiovascular disease, including history or current evidence of coronary
             heart disease, heart failure, cerebrovascular disease, peripheral vascular disease,
             and/or a 10-year risk of CHD > 20% while on or titrated off lipid lowering medication.
             Subjects pending diagnostic procedures for any of those conditions at the time of
             screening will not be eligible for participation.

          -  Renal impairment (for males) as defined by a calculated GFR < 60 mL/min . Renal
             impairment (for females) as defined by a calculated GFR < 55 ml/min.

          -  History of diabetes mellitus, or history of post-prandial and/or random blood glucose
             > 200 mg/dl or fasting glucose > 125 mg/dL or currently taking diabetes medications to
             manage fasting glucose levels (e.g. glitazones, sulfonylureas, insulin, metformin,
             etc.).

          -  History of anemia or treatment of anemia within 12 months of screening or Hgb or Hct
             below the lower limit of reference range for age and gender at screening

          -  History of pancreatitis

          -  Any concurrent serious illness (e.g., severe COPD, HIV positive, liver cirrhosis,
             history of malignancy other than skin cancer within 5 years of initial diagnosis or
             with evidence of recurrence) that may interfere with a subject from completing the
             study

          -  Active peptic ulcer disease (PUD) and/or history of PUD or other gastrointestinal
             bleeding within 12 months prior to screening.

          -  History of kidney stones

          -  History of gout and/or hyperuricemia or taking drugs for hyperuricemia: allopurinol
             and/or probenecid

          -  History of Gilbert's syndrome

          -  Current inadequately controlled hypertension (blood pressure ≥160 mmHg systolic or
             ≥100 mmHg diastolic at screening). If blood pressure medication is changed, blood
             pressure will be re-measured after 6 weeks and must again meet these criteria.

          -  An unwillingness of subjects currently taking aspirin to reduce the daily dose to 81
             mg starting 2 weeks prior to first dose and until the follow-up visit.

          -  Creatinine phosphokinase (CPK) 2X ULN at screening.

          -  A serum uric acid exceeding by ≥ 15% the upper limit of the reference range at
             screening.

          -  PT and/or aPTT above the reference range.

          -  A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
             result within 3 months of screening.

          -  The subject has a positive pre-study drug screen. A minimum list of drugs that will be
             screened for include amphetamines, barbiturates, cocaine, opiates, cannabinoids and
             benzodiazepines.

          -  History of regular alcohol consumption within 6 months of the study defined as:

          -  An average weekly intake of >14 drinks/week for men or >7 drinks/week for women. One
             drink is equivalent to (12 g alcohol) = 5 ounces (150 ml) of wine or 12 ounces (360
             ml) of beer or 1.5 ounces (45 ml) of 80 proof distilled spirits.

          -  Use of the following blood pressure medications is prohibited at any dose: enalapril,
             losartan, captopril

          -  If subjects are titrated or switched to alternative therapy they must be on a stable
             dose for at least 4 weeks prior to randomization.

          -  Subjects will be excluded if they require treatment with systemic corticosteroids

          -  Subjects will be excluded if they take quinolone antibiotics, methotrexate, ibuprofen
             or other medication secreted by renal OAT transporters

          -  Treatment with an investigational drug within 30 days or 5 half-lives (whichever is
             longer) prior to dosing

          -  Exposure to more than four new chemical entities within 12 months prior to the first
             dosing day

          -  History of sensitivity or untoward reaction to the study medications (i.e. GSK256073
             or Niaspan), or components thereof or a history of drug or other allergy that, in the
             opinion of the physician responsible, contraindicates their participation

          -  Where participation in study would result in donation of blood in excess of 500 mL
             within a 56 day period.

          -  A positive test for HIV antibody.

          -  Subject is mentally or legally incapacitated.

          -  Unwillingness or inability to follow the procedures outlined in the protocol.