Botulinum Toxin A to Treat Arm Tremor
Condition: Essential Tremor of the Upper Limbs
MeSH terms: Tremor; Essential Tremor
Intervention: IncobotulinumtoxinA; Placebo
Intervention description: Active ingredient: Clostridium Botulinum neurotoxin Type A free from complexing proteins. Solution for injection prepared by reconstitution of powder with 0.9% Sodium Chloride (NaCl).; Solution for injection prepared by reconstitution of powder with 0.9% Sodium Chloride (NaCl).
Intervention MeSH terms: Botulinum Toxins; Botulinum Toxins, Type A; abobotulinumtoxinA; incobotulinumtoxinA
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Enrollment: 30.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      The objective of this study is to assess the efficacy and safety of a single,
      kinematic-analysis-based intramuscular injection of NT 201, compared with placebo, in
      moderate to marked essential tremor of the upper limb.
    

Eligibility criteria:

        Main Inclusion Criteria:

          -  Diagnosis of 'definite essential tremor' in accordance with modified TRIG criteria, as
             follows:

               -  Bilateral postural tremor with or without kinetic tremor, involving hands and
                  forearms, that is visible and persistent.

               -  It is to be noted that:

               -  Tremor of other body parts may be present in addition to upper limb tremor.

               -  Bilateral tremor may be asymmetric.

               -  Tremor is reported by patient to be persistent, although the amplitude may
                  fluctuate.

          -  First onset of essential tremor at least 6 months before screening with stability of
             the tremor symptoms over 4 weeks and in the opinion of the investigator definite
             diagnosis of essential tremor.

          -  Moderate-to-marked upper-limb postural and/or kinetic tremor at wrist level,
             corresponding to Fahn-Tolosa-Marin upper-limb tremor rating of at least 2 categories
             (scale part C, items 16-23) in the limb to be treated between of 2 or higher.

          -  Visible tremor at wrist level in at least one of the four positions/tasks used in
             kinematic assessments

          -  Tremor deemed by the investigator to require a treatment with 30 - 200 U NT 201 for a
             treatment of up to three joints of the selected upper limb (wrist treatment
             mandatory).

          -  Stable concomitant anti-tremor medication and no clinically relevant findings in
             routine laboratory examinations.

        Main Exclusion Criteria:

          -  Any neurological signs abnormal for the subject's age, other than the tremor itself
             and Froment's maneuver.

          -  Exposure to the following tremorogenic drugs: Lithium, Valproic acid, Amiodarone,
             typical and atypical neuroleptics. Exposure to other than the listed tremorogenic or
             potentially tremorogenic drugs is allowed only if, in the opinion of the investigator,
             this will not interfere with the study drug evaluation. In these cases, a stable
             medication should be reached 4 weeks before screening and intended for the time during
             the study drug evaluation.

          -  Trauma to the central nervous system or the nerves of the target limb within the three
             months preceding the onset of tremor.

          -  Evidence of psychogenic origins of tremor.

          -  Life habits (e.g. smoking, alcohol or substance abuse) prejudicial to study
             participation.

          -  Prior surgery to treat tremor

          -  Recent (16 weeks) treatment with any Botulinum toxin product for any reason.

          -  Relevant recent or planned surgery or other specified relevant treatments and/or
             concomitant disorders.