A Study to Evaluate the Effect of HER2 Activation on rhuMAb 2C4 (Pertuzumab) in Subjects With Advanced Ovarian Cancer
Condition: Ovarian Cancer
MeSH terms: Ovarian Neoplasms; Carcinoma, Ovarian Epithelial
Intervention: Pertuzumab (rhuMAb 2C4)
Intervention MeSH terms: Pertuzumab
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Masking: None (Open Label)
Enrollment: 129.0
Sex: Female
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Advanced, refractory, or recurrent ovarian cancer

Summary:

      The purpose of this study is to determine if the study drug pertuzumab is effective in
      treating patients with advanced ovarian cancer that is refractory to, or has recurred
      following, prior chemotherapy.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Signed informed consent

          -  Willingness to undergo tumor biopsy and disease that is amenable to biopsy (Cohort 1
             only)

          -  Age >=18 years old

          -  Advanced, histologically documented carcinoma of the ovary

          -  Measurable disease with at least one lesion that can be accurately measured per RECIST
             in at least one dimension (longest dimension recorded). Each lesion must be >=20 mm
             when measured by conventional techniques, including palpation, plain X-ray, CT, and
             MRI, or >=10 mm when measured by spiral CT.

          -  Or, clinically or radiologically detectable disease (e.g., ascites, peritoneal
             deposits, mesenteric thickening or lesions that do not fulfill RECIST for measurable
             disease). In addition, the subject must have two consecutive pre-treatment CA 125
             levels that are both greater than 2× the institutional upper limit of normal (ULN) and
             >=40 IU/mL, taken at least 1 week and not more than 3 months apart. The second of the
             two measurements of CA 125 level should not be drawn within 28 days following the
             screening biopsy. The later value must be within 2 weeks of starting rhuMAb 2C4
             treatment.

          -  One or more prior platinum-based chemotherapeutic regimens for the management of
             primary disease containing carboplatin, cisplatin, or another organoplatinum compound

          -  Life expectancy >=12 weeks

          -  ECOG performance status 0 or 1

          -  Use of an effective means of contraception (for women of childbearing potential)

          -  Granulocyte count >=1500/uL, platelet count of >=75,000/uL, and hemoglobin >=9 g/dL
             (hemoglobin may be supported by transfusion or erythropoietin or other approved
             hematopoietic growth factors; darbopoeitin [Aranesp] is permitted)

          -  Serum bilirubin <=1.5× the ULN and alkaline phosphatase, AST, and ALT <=2.5× ULN (ALT,
             AST, and alkaline phosphatase <=5× ULN for subjects with liver metastases)

          -  Serum creatinine <=1.5× ULN

          -  International normalized ratio (INR) <1.5 and activated partial thromboplastin time
             (aPTT) <1.5 ULN (except for subjects receiving warfarin)

        Exclusion Criteria:

          -  Prior treatment with experimental anti-cancer agents within 4 weeks prior to Day 1
             (the day on which the first rhuMAb 2C4 infusion is administered)

          -  Prior treatment with HER pathway inhibitors (e.g., Herceptin [Trastuzumab], Iressa
             [gefitinib], Tarceva [erlotinib hydrochloride], C225, CI1033, and TAK165)

          -  History or clinical evidence of central nervous system or brain metastases

          -  Ejection fraction, determined by ECHO, <50%

          -  Uncontrolled hypercalcemia (>11.5 mg/dL)

          -  Prior exposure to doxorubicin or liposomal doxorubicin >360 mg/m2 , mitoxantrone >120
             mg/m2 , or idarubicin >90 mg/m2

          -  History of other malignancies within 5 years of Day 1 except for adequately treated
             carcinoma in situ of the cervix, ductal carcinoma in situ of the breast, or basal or
             squamous cell skin cancer

          -  History of serious systemic disease, including active infection, uncontrolled
             hypertension (diastolic blood pressure >100 mmHg on two consecutive occasions),
             unstable angina, congestive heart failure, or myocardial infarction within 6 months
             prior to Day 1, or unstable symptomatic arrhythmia requiring medication (subjects with
             chronic atrial arrhythmia, i.e., atrial fibrillation, paroxysmal supraventricular
             tachycardia, or controlled hypertension are eligible)

          -  Ongoing liver disease, including viral or other hepatitis, current alcohol abuse, or
             cirrhosis

          -  Known human immunodeficiency virus infection

          -  Pregnancy or lactation

          -  Major surgery or significant traumatic injury within 3 weeks prior to Day 1 with the
             exception of tumor biopsy for the purposes of the study

          -  Inability to comply with study and follow-up procedures

          -  Any other diseases, metabolic dysfunction, physical examination finding, or clinical
             laboratory finding giving reasonable suspicion of a disease or condition that
             contraindicates the use of an investigational drug or that may affect the
             interpretation of the results or render the subject at high risk from treatment
             complications