A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD5718 After Single and Multiple Ascending Dose Administration to Healthy Male Subjects
Condition: Healthy Male Subjects; Cardiovascular Disease
MeSH terms: Cardiovascular Diseases
Intervention: AZD5718 oral suspension crystalline form (1 to 100 mg/mL) (Part A); AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part A); AZD5718 placebo oral suspension; AZD5718 oral suspension amorphous (1 to 100 mg/mL) (Part B)
Intervention description: Oral suspension single dose; Single and multiple doses; Single and multiple doses; Single and multiple doses
Phase: Phase 1
Study type: Interventional
Primary purpose: Basic Science
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Participant)
Enrollment: 96.0
Sex: Male
Minimum age: 18 Years
Maximum age: 50 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: AZD5718 oral suspension crystalline; AZD5718 oral suspension amorphous; Single ascending dose/multiple ascending dose (SAD/MAD); Placebo-controlled; Safety; Tolerability; Pharmacokinetics; Pharmacodynamics

Summary:

      This is a phase I, randomised, single-blind, placebo-controlled, first-in-human (FIH) single
      and multiple ascending dose study consisting of two parts (Part A [SAD] and Part B [MAD]) to
      assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD5718 in healthy
      male subjects
    

Eligibility criteria:

        Inclusion Criteria:

          1. Provision of signed and dated, written informed consent prior to any study specific
             procedures

          2. Healthy male subjects aged 18 - 50 years, inclusive, with suitable veins for
             cannulation or repeated venepuncture

          3. Have a body mass index (BMI) between 18 and 30 kg/m2 inclusive and weigh at least 50
             kg and no more than 100 kg inclusive

          4. Provision of signed, written and dated informed consent for optional genetic research

        Exclusion Criteria:

          1. History of any clinically significant disease or disorder which, in the opinion of the
             Investigator, may either put the subject at risk because of participation in the
             study, or influence the results or the subject's ability to participate in the study

          2. History or presence of gastrointestinal (GI), hepatic or renal disease, or any other
             condition known to interfere with absorption, distribution, metabolism, or excretion
             of drugs

          3. Any clinically significant illness, medical/surgical procedure, or trauma within 4
             weeks of the administration of investigational medicinal product (IMP)

          4. Any clinically significant abnormalities in clinical chemistry, haematology, or
             urinalysis results at screening and check-in, as judged by the investigator,
             including:

               -  Alanine aminotransferase (ALT) > upper limit of normal (ULN);

               -  Aspartate aminotransferase (AST) > ULN;

               -  Bilirubin (total) > ULN; and

               -  Gamma glutamyl transpeptidase (GGT) > ULN

          5. Any positive result on screening for serum hepatitis B surface antigen (HBsAg),
             hepatitis C antibody and human immunodeficiency virus (HIV)

          6. Suspicion or known Gilbert's syndrome

          7. Abnormal vital signs, after 10 minutes supine rest, at screening and check-in, defined
             as any of the following:

               -  Systolic blood pressure(BP) (SBP) < 90mmHg or ≥ 140 mmHg;

               -  Diastolic BP (DBP) < 50mmHg or ≥ 90 mmHg; and

               -  Pulse < 45 or > 85 beats per minute (bpm)

          8. Any clinically significant abnormalities (at screening and check-in) in rhythm,
             conduction or morphology of the resting ECG and any clinically significant
             abnormalities in the 12-lead ECG, as considered by the investigator that may interfere
             with the interpretation of QTc interval changes, including abnormal ST-T-wave
             morphology, particularly in the protocol defined primary lead or left ventricular
             hypertrophy

          9. Prolonged QTcF (QT interval corrected for heart rate using Fridericia's formula) > 450
             ms or shortened QTcF < 340 ms or family history of long QT syndrome, at screening and
             check-in

         10. PR(PQ) interval (ECG interval measured from the onset of the P wave to the onset of
             the QRS complex) shortening < 120 ms (PR > 110 ms but < 120 ms is acceptable if there
             is no evidence of ventricular pre-excitation), at screening and check-in

         11. PR (PQ) interval prolongation (> 240 ms) intermittent second (Wenckebach block while
             asleep is not exclusive) or third degree AV block, or AV dissociation, at screening
             and check-in

         12. Persistent or intermittent complete bundle branch block (BBB), incomplete bundle
             branch block (IBBB), or intraventricular conduction delay (IVCD) with QRS > 110 ms.
             Subjects with QRS > 110 ms but < 115 ms are acceptable if there is no evidence of, for
             example, ventricular hypertrophy or pre-excitation, at screening and check-in

         13. Known or suspected history of drug abuse, as judged by the investigator

         14. Current smokers or those who have smoked or used nicotine products within the 3 months
             prior to screening

         15. Any history of alcohol abuse or excessive intake of alcohol, as judged by the
             investigator

         16. Positive screen for drugs of abuse, alcohol or cotinine (nicotine) at screening or
             admission to the unit

         17. History of severe allergy/hypersensitivity or ongoing clinically significant
             allergy/hypersensitivity, as judged by the investigator or history of hypersensitivity
             to drugs with a similar chemical structure or class to AZD5718

         18. Excessive intake of caffeine containing drinks or food (e.g., coffee, tea, chocolate),
             as judged by the investigator

         19. Use of drugs with enzyme inducing properties such as St John's Wort within 3 weeks
             prior to the first administration of IMP

         20. Use of any prescribed or non-prescribed medication including antacids, analgesics
             (other than paracetamol/acetaminophen), herbal remedies, megadose vitamins (intake of
             20 to 600 times the recommended daily dose) and minerals during the 2 weeks prior to
             the administration of IMP or longer if the medication has a long half-life

         21. Plasma donation within 1 month of screening or any blood donation/blood loss > 500 mL
             during the 3 months prior to screening

         22. Has received another new chemical entity (defined as a compound which has not been
             approved for marketing) within 3 months of the administration of IMP in this study.
             The period of exclusion is 3 months after the final dose from a previous study

         23. Vulnerable subjects, e.g., kept in detention, protected adults under guardianship,
             trusteeship, or committed to an institution by governmental or juridical order

         24. Involvement of any AstraZeneca, PAREXEL or study site employee or their close
             relatives

         25. Judgment by the investigator that the subject should not participate in the study if
             they have any ongoing or recent (i.e., during the screening period) minor medical
             complaints that may interfere with the interpretation of study data or are considered
             unlikely to comply with study procedures, restrictions and requirements

         26. Subjects who are vegans or have medical dietary restrictions

         27. Subjects who cannot communicate reliably with the investigator

             In addition, any of the following is regarded as a criterion for exclusion from the
             genetic research:

         28. Previous bone marrow transplant

         29. Non-leukocyte depleted whole blood transfusion within 120 days of the date of the
             genetic sample collection