A Phase I, Multicenter, Dose Escalation Study of CAT-8015 in Participants With Chronic Leukemia
Condition: Leukemia, Lymphoma, Chronic Lymphocytic; Leukemia, Prolymphocytic Leukemia, Small; Lymphocytic Lymphoma, Moxetumomab Pasudotox
MeSH terms: Lymphoma; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Prolymphocytic
Intervention: CAT-8015 5 mcg/kg; CAT-8015 10 mcg/kg; CAT-8015 20 mcg/kg
Intervention description: Participants received a single intravenous infusion of 5 mcg/kg moxetumomab pasudotox (CAT-8015) on Days 1, 3, and 5 of every 28-day cycle and continued cycles of therapy until progressive disease (PD) or until otherwise they become ineligible.; Participants received a single intravenous infusion of 10 mcg/kg moxetumomab pasudotox (CAT-8015) on Days 1, 3, and 5 of every 28-day cycle and continued cycles of therapy until progressive disease (PD) or until otherwise they become ineligible.; Participants received a single intravenous infusion of 20 mcg/kg moxetumomab pasudotox (CAT-8015) on Days 1, 3, and 5 of every 28-day cycle and continued cycles of therapy until progressive disease (PD) or until otherwise they become ineligible.
Intervention MeSH terms: Immunotoxin HA22
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 11.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Chronic Lymphocytic Leukemia; Prolymphocytic Leukemia; Small Lymphocytic Lymphoma; Moxetumomab pasudotox

Summary:

      This was a multicenter, Phase 1, standard 3+3 dose-escalation study to evaluate the safety
      and anti-neoplastic activity of moxetumomab pasudotox in relapsed or refractory participants
      with chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PLL) or Small Lymphocytic
      Lymphoma (SLL).
    

Eligibility criteria:

        Inclusion Criteria:

          -  Confirmed diagnosis of B-Cell Leukemia [(chronic lymphocytic leukemia (CLL),
             prolymphocytic leukemia (PLL), or Small lymphocytic leukemia (SLL)]

          -  Measurable Disease

          -  Disease characteristics: Participants with CLL or SLL are eligible if they have failed
             2 or more prior courses of standard chemo and/or biologic therapy (example, Rituxan)
             and PLL will be eligible if they have failed at least one prior standard
             chemotherapeutic regimen. Medical indications for treatment include progressive
             disease-related symptoms, progressive cytopenias due to marrow involvement,
             progressive or painful splenomegaly or adenopathy, rapidly increasing lymphocytosis,
             autoimmune hemolytic anemia or thrombocytopenia and increased frequency of infections.

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

          -  Participants with other cancers who meet eligibility criteria and have had less than 5
             years of disease-free survival will be considered on a case-by-case basis

          -  Life expectancy of greater than 6 months, as assessed by the principal investigator

          -  Must be able to understand and sign the informed consent

          -  Must be at least 18 years old

          -  Female and Male participants agree to use an approved method of contraception during
             the study

        Exclusion Criteria:

          -  History of allogeneic bone marrow transplant.

          -  Documented and ongoing central nervous system involvement with their malignant disease
             [history of central nervous system (CNS) involvement is not an exclusion criterion]

          -  Pregnant or breast-feeding females

          -  Participants who plasma contains either a significant level of antibody to CAT-8015 as
             measured by ELISA, or antibody that neutralizes the binding of CAT-8015 to CD22 as
             measured by a competition ELISA.

          -  HIV positive serology (due to increased risk of severe infection and unknown
             interaction of CAT-8015 with antiretroviral drugs)

          -  Hepatitis B surface antigen positive

          -  Uncontrolled, symptomatic, intercurrent illness including but not limited to:
             infections requiring systemic antibiotics, congestive heart failure, unstable angina
             pectoris, cardiac arrhythmia, psychiatric illness, or social situations that would
             limit compliance with study requirements.

          -  Hepatic function: Serum transaminases [either alanine aminotransferase (ALT) or
             aspartate aminotransferase (AST)] or direct bilirubin greater than or equal to Grade
             2, unless bilirubin is due to Gilbert's disease

          -  Renal function: Serum creatinine clearance is less than or equal to 60 millilitre per
             minute (mL/min) as estimated by Cockcroft-Gault formula

        Hematologic function:

          -  The ANC less than 1000/cubic millimeter (cmm), or platelet count less than 50,000/cmm,
             if these cytopenias are not judged by the investigator to be due to underlying disease
             (that is, potentially reversible with anti-neoplastic therapy).

          -  A participant will not be excluded because of pancytopenia greater than or equal to
             Grade 3, or erythropoietin dependence, if it is due to disease, based on the results
             of bone marrow studies.

          -  Baseline coagulopathy greater than or equal to grade 3 unless due to anticoagulant
             therapy

        Pulmonary function:

        - Participants with less than 50 percent (%) of predicted forced expiratory volume (FEV-1)
        or less than 50% of predicted diffusing capacity for carbon monoxide (DLCO) corrected for
        hemoglobin concentration and alveolar volume. Note: Participants with no prior history of
        pulmonary illness are not required to have pulmonary function test (PFTs). FEV1 will be
        assessed after bronchodilator therapy.

        Recent prior therapy:

          -  Cytotoxic chemotherapy, corticosteroids (except stable doses of prednisone), whole
             body electron beam radiation therapy, hormonal, biologic or other standard or any
             investigational therapy of the malignancy for 3 weeks prior to entry into the trial.

          -  Less than or equal to 1 month prior monoclonal antibody therapy (that is, rituximab)

          -  Participants who are receiving or have received radiation therapy less than 3 weeks
             prior to study entry will not be excluded providing the volume of the bone marrow
             treated is less than 10% and also the participant has measurable disease outside the
             radiation report.

          -  Any history of prior pseudomonas - exotoxin immunotoxin administrator