A Study of LY2881835 in Healthy People and People With Diabetes
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus; Diabetes Mellitus, Type 2
Intervention: LY2881835; Placebo
Intervention description: Administered orally; Administered orally
Phase: Phase 1
Study type: Interventional
Primary purpose: Basic Science
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Single (Participant)
Enrollment: 18.0
Sex: All
Minimum age: 21 Years
Maximum age: 65 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      This will be the first study in which LY2881835 is given to humans in order to evaluate the
      safety and any side effects of LY2881835 in humans as well as how long LY2881835 stays in the
      body and its effect on blood sugar levels.

      The study consists of two parts. In part A, healthy subjects will participate and in part B,
      patients with type 2 Diabetes Mellitus (T2DM) will participate.
    

Eligibility criteria:

        Inclusion Criteria:

        All subjects:

          -  Are a healthy male or a healthy female who cannot become pregnant, or are patients
             with Type 2 Diabetes Mellitus (T2DM) who are not taking any drugs to lower blood sugar
             except metformin

          -  Have a body mass index (BMI) of at least 18.5 kilograms per meter squared (kg/m²) at
             screening

          -  Have blood pressure, pulse rate and clinical laboratory tests within the normal range
             for the population or investigator site, or with abnormalities deemed clinical
             insignificant by the investigator

          -  Have veins that are suitable for easy blood collection

          -  Are reliable and willing to be available for the whole study and are willing to follow
             study procedures

          -  Must have given written informed consent

        Subjects with Type 2 Diabetes Mellitus (T2DM) only:

          -  Do not have any change to their diabetes treatment for at least 4 weeks prior to
             screening

          -  Have a glycosylated hemoglobin (HbA1c) level greater than or equal to 6% and less than
             or equal to 11% at screening

        Exclusion Criteria:

        All subjects:

          -  Are currently participating in or were in another new drug or medical research study
             in the last 30 days

          -  Have participated in this study before

          -  Have known allergies to compounds related to the study drug

          -  Currently have or used to have health problems or laboratory test results that in the
             opinion of the doctor, could interfere with understanding the results of this study

          -  Intend to use over-the-counter or prescription medications within 14 days prior to
             dosing or during the study. Hormone replacement therapy and intermittent use of
             paracetamol during the study is acceptable. For patients with Type 2 Diabetes
             Mellitus, medicines for control of high fats (For example, cholesterol), high blood
             pressure, are allowed.

          -  Have electrocardiogram (ECG) readings that are not suitable for the study

          -  Are unwilling to follow dietary restrictions/requirements for the study including 1)
             refrain from consuming foods or beverages containing grapefruit pomelo, star fruit, or
             Seville orange within 14 days of the start of the study drug dosing until collection
             of the last blood sample for drug assay and 2) consume only the meals provided during
             inpatient stays at the clinical research unit

          -  Have a history of drug or alcohol abuse

          -  Are infected with hepatitis B

          -  Are infected with human immunodeficiency disease virus (HIV)

          -  Have donated 450 milliliters (mL) or more of blood in the last 3 months or provided
             any blood donation within the last month from screening

          -  Have a regular alcohol intake greater than 21 units per week (males) and 14 units per
             week (females) or are not willing to abstain from alcohol while in the research unit

          -  Smoke more than 10 cigarettes per day or are not willing to abstain from smoking while
             at the clinic

          -  The study doctor thinks the subject should not participate for any other reasons

        Subjects with Type 2 Diabetes Mellitus (T2DM) only:

          -  Have health complications due to poorly controlled diabetes as shown by blood and
             urine laboratory test results or based on physical examination and medical assessment,
             as determined by the study doctor

          -  Were hospitalised for poor control of their diabetes (ketoacidotic episode) in the
             last 6 months

          -  Currently using or have used insulin in the last 1 year to control their diabetes