A Study to Evaluate the Effect of Activated Charcoal on the Absorption of LY2216684 in Healthy Subjects
Condition: Depressive Disorder, Major
MeSH terms: Depressive Disorder; Depressive Disorder, Major
Intervention: LY2216684; Activated Charcoal
Intervention description: Administered orally; Administered orally
Intervention MeSH terms: Charcoal
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Enrollment: 22.0
Sex: All
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The study involves a single oral dose of 18 mg (2 x 9mg tablets) LY2216684 taken on 2
      occasions, once with activated charcoal and once without activated charcoal.

      The study will evaluate the effect of charcoal on the absorption of LY2216684. Side effects
      will be documented. There will be 2 study periods each lasting up to 5 days. There will be at
      least 7 days between the two doses and a follow up will occur at least 7 days after the last
      dose. Screening is required within 30 days prior to the start of the study.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Are overtly healthy, as determined by medical history and physical examination

             - Male subjects: Agree to use a reliable method of birth control during the study and
             for 1 month following the last dose of the study drug

             - Female subjects: Are women of child-bearing potential who test negative for
             pregnancy at the time of enrollment, have used a reliable method of birth control
             prior to administration of study drug, and agree to use a reliable method of birth
             control during the study and for 1 month following the last dose of study drug; or
             women not of child-bearing potential due to surgical sterilization (hysterectomy or
             bilateral oophorectomy or tubal ligation) or menopause (at least 1 year without menses
             or 6 months without menses and a follicle stimulating hormone [FSH] >40 mIU/mL
             [milli-international-units/milliliter])

          -  Have a body weight >50 kg

          -  Have clinical laboratory test results within normal reference range for the population
             or investigator site, or results with acceptable deviations that are judged to be not
             clinically significant by the investigator

          -  Have venous access sufficient to allow for blood sampling as per the protocol

          -  Are reliable and willing to make themselves available for the duration of the study
             and are willing to follow study procedures

          -  Have given written informed consent approved by Lilly and the institutional review
             board (IRB) governing the site

          -  Have normal blood pressure (BP) and pulse rate (sitting position)

        Exclusion Criteria:

          -  Are currently enrolled in, have completed or discontinued within the last 30 days
             from, a clinical trial involving an investigational product other than the
             investigational product used in this study; or are concurrently enrolled in any other
             type of medical research judged not to be scientifically or medically compatible with
             this study

          -  Have known allergies to LY2216684, related compounds, or any components of the
             formulation

          -  Are persons who have previously received the investigational product in this study,
             have completed or withdrawn from this study or any other study investigating LY2216684
             within 6 months prior to Screening

          -  Have an abnormality in the 12-lead electrocardiogram (ECG) that, in the opinion of the
             investigator, increases the risks associated with participating in the study

          -  Have a history of or current cardiovascular, respiratory, hepatic, renal,
             gastrointestinal, endocrine, hematological, or neurological disorders capable of
             significantly altering the absorption, metabolism, or elimination of drugs; of
             constituting a risk when taking the study medication; or of interfering with the
             interpretation of data

          -  Have a history or show evidence of significant active neuropsychiatric disease or have
             a history of suicide attempt or ideation

          -  Have a documented or suspected history of glaucoma

          -  Regularly use known drugs of abuse and/or show positive findings on urinary drug
             screening

          -  Show evidence of human immunodeficiency virus (HIV) infection and/or positive human
             HIV antibodies

          -  Show evidence of hepatitis C and/or positive hepatitis C antibody

          -  Show evidence of hepatitis B and/or positive hepatitis B surface antigen

          -  Are women who are lactating

          -  Intend to use over-the-counter or prescription medication within 14 days prior to
             dosing unless deemed acceptable by the investigator and Sponsor's medical monitor.
             Exceptions include influenza vaccinations, the use of topical medication (provided
             there is no evidence of chronic dosing with the risk of systemic exposure), occasional
             use of acetaminophen/paracetamol/ibuprofen, hormone replacement therapy including
             thyroid replacement (stable dose for at least 1 month), and stable doses (at least 1
             month) of oral contraceptive therapy

          -  Have donated blood of more than 500 mL (milliliter) within the last month

          -  Have an average weekly alcohol intake that exceeds 21 units per week (males) or 14
             units per week (females), or are unwilling to stop alcohol consumption from 48 hours
             prior to dosing in each period until discharge in each period (1 unit = 12 oz [ounces]
             or 360 mL of beer; 5 oz or 150 mL of wine; 1.5 oz or 45 mL of distilled spirits)

          -  Consume 5 or more cups of coffee (or other beverages or foods of comparable caffeine
             content) per day, on a habitual basis, or are unwilling to stop caffeine consumption
             from 48 hours prior to dosing in each period until discharge in each period

          -  Subjects unwilling to adhere to the smoking restrictions of the Clinical Research Unit
             (CRU) while a resident of the CRU.

          -  Have consumed grapefruit or grapefruit-containing products 7 days prior to enrollment
             or are unwilling to avoid them during the study

          -  Subjects determined to be unsuitable by the investigator for any reason