Study of Preladenant (MK-3814) Alone and With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3814A-062)
Condition: Neoplasm
Intervention: preladenant; pembrolizumab
Intervention description: Administered as an oral capsule BID on Days 1 through 21 of each 21-day cycle; Administered as IV infusion on Day 1 of each 21-day cycle
Intervention MeSH terms: Pembrolizumab
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 10.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Advanced Solid Tumor; Programmed Cell Death Receptor 1 (PD-1); Programmed Cell Death Receptor Ligand 1 (PD-L1); PD1; PD-1; PDL1; PD-L1

Summary:

      The purpose of this study is to evaluate the safety and preliminary efficacy of preladenant
      (MK-3814A) alone and in combination with pembrolizumab (MK-3475) (pembro) in participants
      with advanced solid tumors that have not responded to prior therapy. This study will be done
      in 2 parts. Part 1 will identify and confirm the recommended Phase 2 dose (RP2D) of
      preladenant when given alone or in combination with pembrolizumab. Part 2 of the study will
      determine the safety and efficacy of preladenant in combination with pembrolizumab at the
      RP2D in participants with select solid tumors .
    

Eligibility criteria:

        Inclusion Criteria:

          -  Has a histologically- or pathologically-documented, locally-advanced or metastatic
             solid tumor for which standard therapy, either does not exist or has been proven
             ineffective, intolerable or refused by the participant. Each participant must have
             received at least one and up to five prior lines of cancer treatment regimens,
             excluding neo-adjuvant, adjuvant, maintenance treatment and surgery

          -  Has provided a tumor tissue sample (archival or newly obtained core or excisional
             biopsy of a tumor lesion)

          -  Has measurable disease per RECIST 1.1

          -  Has an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

          -  Females must not be pregnant

          -  Female and male participants of reproductive potential must agree to use adequate
             contraception starting from the first dose of study therapy, throughout the study
             period, and for up to 120 days after the last dose of study therapy

        Exclusion Criteria:

          -  Has disease that is suitable for local treatment administered with curative intent

          -  Has received previous treatment with an immunomodulatory agent (e.g, anti- Programmed
             Cell Death Receptor 1/ Programmed Cell Death Receptor Ligand 1 or anti-cytotoxic
             T-lymphocyte-associated antigen-4) and was discontinued from treatment due to a Grade
             3 or higher immune-related adverse event

          -  Has received previous treatment with an adenosine A2a receptor antagonist (e.g.
             CPI-444, HTL1071, PBF-509)

          -  Has had chemotherapy, definitive radiation, or biological cancer therapy within 4
             weeks of the first dose of study therapy, or has not recovered to Common Toxicity
             Criteria for Adverse Events (CTCAE) grade 1 or better from any adverse event

          -  Is currently participating or has participated in a study with an investigational
             agent or using an investigational device within 28 days of the first dose of study
             therapy

          -  Is currently taking or has taken drugs that interfere with Cytochrome P450 (CYP)3A4 or
             CYP2C8 or grapefruit and star fruit in diet within 14 days of the first dose of study
             therapy

          -  Is currently taking or has taken proton pump inhibitors within 5 days of the first
             dose of study therapy

          -  Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
             or any other form of immunosuppressive therapy within 7 days of the first dose of
             study therapy

          -  Is expected to require any other form of systemic or localized antineoplastic therapy
             while on study

          -  Has a history of a second malignancy, unless potentially curative treatment has been
             completed, with no evidence of malignancy for 5 years

          -  Has clinically active central nervous system metastases and/or carcinomatous
             meningitis

          -  History of a severe hypersensitivity reaction to treatment with the monoclonal
             antibody/components of the study drug

          -  Has an active infection requiring therapy

          -  History of interstitial lung disease

          -  History of (non-infectious) pneumonitis that required steroids or current pneumonitis

          -  History of active tuberculosis

          -  Has an active autoimmune disease that has required systemic treatment in the past 2
             years

          -  Has received a live-virus vaccine within 30 days of the first dose of study therapy

          -  Has known Human Immunodeficiency Virus (HIV) (HIV 1 or 2 antibodies) and/or known
             active and acute Hepatitis B or C infections

          -  Has known psychiatric or substance abuse disorders that would interfere with the
             ability to cooperate with the requirements of the study

          -  Is pregnant or breastfeeding, or expecting to conceive or father children within the
             projected duration of the study

          -  Has not fully recovered from any effects of major surgery without significant
             detectable infection

          -  Has had surgery that required general anesthesia within 2 weeks of the first dose of
             study therapy

          -  Has had surgery that required regional/epidural anesthesia within 72 hours of the
             first dose of study therapy