A Single- and Multiple-Dose Study of the Pharmacokinetics of TAK-491 in Healthy Chinese Participants
Condition: Healthy Volunteer
Intervention: TAK-491; TAK-491 placebo
Intervention description: TAK-491 tablets; TAK-491 placebo-matching tablets
Intervention MeSH terms: Azilsartan medoxomil
Phase: Phase 1
Study type: Interventional
Primary purpose: Other
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 64.0
Sex: All
Minimum age: 18 Years
Maximum age: 45 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Drug therapy

Summary:

      The purpose of this study is to assess the pharmacokinetics and safety of single- and
      multiple-dose of TAK-491 in healthy Chinese participants.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Is capable of understanding and complying with protocol requirements.

          2. The participant or, when applicable, the legally acceptable representative signs and
             dates a written, informed consent form and any required privacy authorization prior to
             the initiation of any study procedures.

          3. Is a healthy adult male or female of Chinese descent.

          4. Is aged 18 to 45 years, inclusive, at the time of informed consent and first study
             medication dose.

          5. Has a body mass index (BMI) greater than or equal to (>=) 19.0 kilogram per square
             meter (kg/m^2) and less than (<) 24.0 kg/m^2, inclusive at Screening.

          6. Has clinical laboratory evaluations (including clinical chemistry [fasted for at least
             8 hours for the screening assessment], hematology, and complete urinalysis) within the
             reference range for the testing laboratory, unless the results were deemed by the
             investigator to be not clinically significant at Screening and Check-in (Day -1).

          7. Is willing to refrain from strenuous exercise, from 72 hours before Check-in (Day-1)
             until after Final Visit.

          8. A female of childbearing potential who is sexually active with a nonsterilized male
             partner agrees to use routinely adequate contraception from signing of informed
             consent throughout the duration of the study and for 30 days after the last dose of
             study drug.

        Exclusion Criteria:

          1. Has received any investigational compound within 30 days prior to Screening.

          2. Has received TAK-491 in a previous clinical study or as a therapeutic agent.

          3. Is an immediate family member, study site employee, or in a dependant relationship
             with a study site employee who is involved in the conduct of this study (example,
             spouse, parent, child, sibling) or may consent under duress.

          4. Has history of uncontrolled, clinically significant manifestations of metabolic
             (including diabetes mellitus, hypercholesterolemia, or dyslipidemia), endocrine,
             hematologic, pulmonary, cardiovascular, gastrointestinal, neurological, rheumatologic,
             skin and subcutaneous tissue disorders, infectious, hepatic, renal, urologic,
             immunologic, psychiatric or mood disorders (including any past history of suicide
             attempt), or a history of lactose intolerance, which may impact the ability of the
             participant to participate or potentially confound the study results.

          5. Has a known hypersensitivity to any component of the formulation of TAK-491 or other
             AII inhibitors or related compounds.

          6. Has a positive urine drug result for drugs of abuse or breath alcohol test at
             Screening or Check-in (Day -1).

          7. Has a history of drug abuse (defined as any illicit drug use) or a history of alcohol
             abuse within 1 year prior to the Screening visit or is unwilling to agree to abstain
             from alcohol and drugs throughout the study.

          8. Has taken any excluded medication, supplements, or food products.

          9. If female, the participant is pregnant or lactating or intending to become pregnant
             before, during, or within 30 days after participating in this study; or intending to
             donate ova during such time period.

         10. Has current or recent (within 6 months) gastrointestinal disease that would be
             expected to influence the absorption of drugs (that is, a history of malabsorption,
             esophageal reflux, peptic ulcer disease, erosive esophagitis frequent [more than once
             per week] occurrence of heartburn, or any surgical intervention [example,
             cholecystectomy]).

         11. Has a history of cancer, except basal cell carcinoma which has been in remission for
             at least 5 years prior to Day 1.

         12. Has positive test result for anti-Human immunodeficiency virus (HIV), anti- hepatitis
             C virus (HCV) antibodies, or for hepatitis B surface antigen (HBsAg) at Screening.

         13. Has used nicotine-containing products (including but not limited to cigarettes, pipes,
             cigars, chewing tobacco, nicotine patch or nicotine gum) within 28 days prior to
             Check-in (Day -1). Cotinine test is positive at Screening or Check-in (Day -1).

         14. Has poor peripheral venous access.

         15. Has donated or lost 450 milliliter (mL) or more of his or her blood volume (including
             plasmapheresis), or had a transfusion of any blood product within 30 days prior to Day
             1.

         16. Has a Screening or Check-in (Day -1) abnormal (clinically significant)
             electrocardiogram (ECG). Entry of any participants with an abnormal (not clinically
             significant) ECG must be approved, and documented by signature by the principal
             investigator.

         17. Has abnormal Screening or Check-in (Day -1) laboratory values that suggest a
             clinically significant underlying disease or participant with the following lab
             abnormalities: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST)
             greater than (>) 1.5 times the upper limits of normal.

         18. Has a hemoglobin value <12 gram per deciliter (g/dL) at Screening.

         19. Has a systolic blood pressure <110 and >=160 millimeter of Mercury (mmHg) or a
             diastolic blood pressure <60 and >=100 mmHg at Screening or Check-in (Day -1).