A Bioavailability Study of LY2452473 and Tadalafil
Condition: Erectile Dysfunction
MeSH terms: Erectile Dysfunction
Intervention: LY2452473; Tadalafil; LY900010
Intervention description: Administered orally; Administered orally; Administered orally
Intervention MeSH terms: Tadalafil
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Enrollment: 24.0
Sex: Male
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: testosterone; energy; libido; erectile function; weak muscles

Summary:

      This study compares LY2452473 taken orally as a 5 milligram (mg) capsule at the same time as
      a 5 mg tadalafil tablet with three different combination tablets (LY900010) of 5 mg LY2452473
      and 5 mg tadalafil taken orally. The study will evaluate the amount of LY2452473 and
      tadalafil circulating in the blood for each treatment. Side effects will be documented. This
      study is approximately 34 days not including screening.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Overtly healthy male, as determined by medical history and physical examination

          -  Are between a body mass index of 18.5 and 30 kilograms per meter squared (kg/m²),
             inclusive at screening

          -  Have clinical laboratory test results within normal reference range for the population
             or investigator site, or results with acceptable deviations that are judged to be not
             clinically significant by the investigator

          -  Normal blood pressure and heart rate (HR; sitting) as determined by the investigator

          -  Have venous access sufficient to allow blood sampling

          -  Are reliable and willing to make themselves available for the duration of the study,
             and will abide by the research unit policies and procedures and study restrictions

          -  Have given written informed consent approved by Lilly and the ethical review board
             (ERB) governing the site

          -  Men must agree to use a reliable method of birth control (for example, vasectomy,
             condom with contraceptive foam, abstinence, or female partner's use of oral
             contraceptives or Norplant®; a reliable barrier method of birth control [diaphragm
             with contraceptive jelly]; or intrauterine device), during the study and for 1 month
             following the last dose of study drug

        Exclusion Criteria:

          -  Have known allergies to LY2452473, tadalafil, or related compounds

          -  History of severe allergies or multiple adverse drug reactions

          -  Have a history or presence of cardiovascular, respiratory, hepatic (including history
             of cholecystectomy), renal, gastrointestinal, endocrine, hematological, or
             neurological disorders capable of significantly altering the absorption, metabolism,
             or elimination of drugs; of constituting a risk when taking the study medication; or
             of interfering with the interpretation of data

          -  Any abnormality in the 12-lead electrocardiogram (ECG) that in the opinion of the
             investigator places the subject at an unacceptable risk for study participation

          -  Show evidence of significant active neuropsychiatric disease

          -  History of significant retinal pathology

          -  Have a history of glaucoma

          -  Have a history of unexplained syncope episodes

          -  Show evidence of hepatitis C and/or positive hepatitis C antibody

          -  Show evidence of hepatitis B and/or positive hepatitis B surface antigen

          -  Show evidence of human immunodeficiency virus (HIV) and/or positive HIV antibodies

          -  Intended use of over-the-counter or herbal remedies within 7 days prior to dosing or
             during the study

          -  Intended use of prescription medication within 14 days prior to dosing or during the
             study

          -  Are not willing to refrain from consumption of any food, or drink any beverage
             containing grapefruit, pomelo, or starfruit for at least 2 weeks prior to the start of
             the study until its conclusion

          -  Heavy caffeine drinkers defined by a regular intake of more than 5 cups of coffee (or
             equivalent in xanthine-containing beverages) per day or subjects who have not had
             consistent daily caffeine consumption for 1 month prior to study entry or subjects not
             willing to maintain consistent caffeine consumption during the study

          -  Use of drugs of abuse, as evidenced by history, and/or positive findings on urinary
             drug screening

          -  Have an average weekly alcohol intake that exceeds 14 units per week or are unwilling
             to stop alcohol consumption for the duration of the study (1 unit = 12 ounces [oz] or
             360 milliliters (mL) of beer; 5 oz or 150 mL of wine; 1.5 oz or 45 mL of distilled
             spirits)

          -  Is currently a smoker or uses tobacco products on a regular basis and has not had
             consistent daily tobacco use for 1 month prior to study entry or subjects not willing
             to maintain consistent tobacco use during the study

          -  Have a history of blood donation of 1 unit (approximately 450 mL) or more in the last
             3 months prior to study entry

          -  Have previously completed or withdrawn from this study or any other study
             investigating LY2452473

          -  Within 30 days of the initial dose of study drug, have received treatment with a drug
             that has not received regulatory approval for any indication

          -  Deemed unsuitable by the investigator for any other reason

          -  Are currently enrolled in, or discontinued within the last 30 days from, a clinical
             trial involving an investigational drug or device or off-label use of a drug or device
             (other than the study drug/device used in this study), or are concurrently enrolled in
             any other type of medical research judged not to be scientifically or medically
             compatible with this study