A Study to Compare the Effect of Giving Dulaglutide Using an Auto-injector Versus a Manual Syringe
Condition: Diabetes Mellitus, Type 2
MeSH terms: Diabetes Mellitus, Type 2
Intervention: Dulaglutide
Intervention description: Administered by subcutaneous (SC) injection
Intervention MeSH terms: Dulaglutide
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Enrollment: 50.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The study involves 2 injections of 1.5 milligrams (mg) dulaglutide, 1 given by a pre-filled
      manual syringe, the other given by an auto-injector. Injections will be separated by a
      minimum 28-day washout period. The study will evaluate if the levels of drug in the blood are
      similar when given by each method. Participation in the study is likely to take approximately
      7 weeks, not including screening.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Are overtly healthy males or females, as determined by medical history and physical
             examination

          -  Male participants with female partners of child-bearing potential or partners who are
             pregnant or breastfeeding agree to use a reliable method of contraception from the
             time of the first dose until 3 months after the last dose of investigational product,
             as determined by the investigator

          -  The method may be one of the following:

               -  condom with spermicidal agent

               -  male participant sterilization

               -  true abstinence (which is in line with the participant's usual lifestyle choice;
                  withdrawal or calendar methods are not considered acceptable)

          -  Female participants not of child-bearing potential (that is, are postmenopausal or
             permanently sterilized [such as, tubal occlusion, hysterectomy, bilateral
             salpingectomy, bilateral oophorectomy]). Such participants will not be required to use
             contraception but must test negative for pregnancy at the time of enrollment

          -  Postmenopausal is defined as at least 1 year post cessation of menses (without an
             alternative medical cause) or spontaneous amenorrhea for 6 to 12 months, with follicle
             stimulating hormone (FSH) ≥40 milli-international units per milliliters (mIU/mL)

          -  Female participants who have undergone sterilization by tubal ligation agree to use a
             condom in conjunction with spermicidal gel, foam, cream, film or suppository from the
             time of screening until 3 months after the last dose of investigational product. Such
             participants must also test negative for pregnancy at the time of enrollment

          -  Have a body mass index (BMI) of 18.5 to 32.0 kilograms per meters squared (kg/m^2),
             inclusive, at screening

          -  Have clinical laboratory test results within the normal reference range for the
             population or investigator site, or results with acceptable deviations that are judged
             to be not clinically significant by the investigator

          -  Have venous access sufficient to allow for blood sampling as per the protocol

          -  Are reliable and willing to make themselves available for the duration of the study
             and are willing to follow study procedures and are willing to follow study
             restrictions

          -  Have given written informed consent approved by Lilly and the ethical review board
             (ERB) governing the site

        Exclusion Criteria:

          -  Are currently enrolled in or have completed or discontinued within the last 30 days
             from a clinical trial involving an investigational product, or are concurrently
             enrolled in any other type of medical research judged not to be scientifically or
             medically compatible with this study

          -  Have known allergies to Glucagon-like peptide 1 (GLP-1) -related compounds including
             dulaglutide, or any components of the formulation

          -  Are persons who have previously completed or withdrawn from this study or any other
             study investigating dulaglutide in the 3 months prior to screening or have received
             glucagon-like peptides or incretin mimetics in the 3 months prior to screening

          -  Have an abnormality in the 12-lead electrocardiogram (ECG) that, in the opinion of the
             investigator, increases the risks associated with participating in the study

          -  Have an abnormal blood pressure (after at least 5 minutes sitting) that, in the
             opinion of the investigator, increases the risks associated with participating in the
             study

          -  Have a history or presence of cardiovascular, respiratory, hepatic, renal, endocrine,
             hematological, or neurological disorders capable of significantly altering the
             absorption, metabolism, or elimination of drugs; of constituting a risk when taking
             the study medication; or of interfering with the interpretation of data

          -  Have a history or presence of pancreatitis (history of chronic pancreatitis or
             idiopathic acute pancreatitis) or gastrointestinal disorder, for example relevant
             esophageal reflux or gall bladder disease, or any gastrointestinal disease which
             impacts gastric emptying (such as, gastric bypass surgery, pyloric stenosis, with the
             exception of appendectomy) or could be aggravated by GLP-1 analogs. Participants with
             dyslipidemia, and participants who had cholecystolithiasis (removal of gall stones)
             and/or cholecystectomy (removal of gall bladder) in the past, with no further
             sequelae, may be included in the study at the discretion of the screening physician

          -  Show evidence of significant active neuropsychiatric disease

          -  Have family history of medullary thyroid cancer (MTC) or a genetic condition that
             predisposes to MTC

          -  Regularly use known drugs of abuse and/or show positive findings on urinary drug
             screening

          -  Show evidence of human immunodeficiency virus (HIV) infection and/or positive human
             HIV antibodies

          -  Show evidence of hepatitis C and/or positive hepatitis C antibody

          -  Show evidence of hepatitis B and/or positive hepatitis B surface antigen

          -  Are women with a positive pregnancy test or women who are lactating

          -  Have used or intend to use over-the-counter medication other than acetaminophen within
             7 days prior to dosing or prescription medication (with the exception of
             vitamin/mineral supplements and/or hormone replacement therapy [HRT]) within 14 days
             prior to dosing

          -  Have donated blood of more than 500 milliliters (mL) within the last month

          -  Have an average weekly alcohol intake that exceeds 21 units per week (males up to age
             65) and 14 units per week (males over 65 and females), or are unwilling to adhere to
             the alcohol restrictions (1 unit = 12 ounces [oz] or 360 mL of beer; 5 oz or 150 mL of
             wine; 1.5 oz or 45 mL of distilled spirits)

          -  Smoke more than 10 cigarettes (or equivalent in nicotine) per day, and are unwilling
             to refrain from smoking on the day of dulaglutide administration or are unable to
             abide by clinical research unit (CRU) restrictions

          -  In the opinion of the investigator or sponsor, are unsuitable for inclusion in the
             study