Drug-Drug Interaction Study Between TAK-272 and Itraconazole, Digoxin or Midazolam
Condition: Japanese Healthy Adult Males
Intervention: TAK-272; Digoxin; Itraconazole; Midazolam
Intervention description: TAK-272 tablet.; Digoxin tablet.; Itraconazole oral solution; Midazolam syrup.
Intervention MeSH terms: Itraconazole; Digoxin; Midazolam; Imarikiren hydrochloride
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 34.0
Sex: Male
Minimum age: 20 Years
Maximum age: 35 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The purpose of this study is to evaluate the effect of repeated-dose administration of
      itraconazole on the pharmacokinetics of TAK-272, as well as the effect of repeated-dose
      administration of TAK-272 on the pharmacokinetics of digoxin or midazolam in healthy Japanese
      adult males.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Is capable of understanding and complying with protocol requirements.

          2. Who can sign and date the informed consent form before the initiation of the study
             procedure.

          3. Healthy Japanese adult male volunteer.

          4. Is of 20 to 35 years of age at the time of informed consent

          5. Weighs 50 kilogram (kg) or more with a body mass index (BMI) of 18.5 to less than 25.0
             kilogram per square meter (kg/m^2) at the screening test.

          6. Male participant who was nonsterilized and sexually active with a female partner of
             childbearing potential had to agree to use adequate contraception from signing of
             informed consent throughout the duration of the study and for 12 weeks after the
             completion of the study.

        Exclusion Criteria:

          1. Who was administered any investigational product within 16 weeks (112 days) prior to
             the initial drug administration.

          2. Who has received TAK-272 in previous.

          3. Employees of the study site, their family members, those who are in a dependency
             relationship with employees of the study site involved in the conduct of the study
             (example, spouse, parents, children, brothers and sisters), or those who might be
             coerced to consent to participate in the study.

          4. Who has poorly controlled, clinically significant abnormalities of the nervous system,
             cardiovascular system, lungs, liver, kidneys, metabolism, gastrointestinal system,
             urinary system, endocrinological system or other organs or systems, and which may
             possibly affect study participation or study results.

          5. Who has a history of serious hepatic disease.

          6. Who has atrioventricular block or sinoatrial block.

          7. Has digitalis intoxication.

          8. Has acute narrow-angle glaucoma.

          9. Has myasthenia gravis.

         10. Has hypersensitivity to TAK-272 or any other renin inhibitors.

         11. Has hypersensitivity to itraconazole, digoxin, digitalis preparation, or midazolam.

         12. Has allergy to cherries.

         13. Has a positive to urine test for drug abuse at the screening.

         14. Has a history of drug abuse (defined as illegal drug use) or alcohol addiction within
             1 year prior to the screening visit, and those who are not willing to give up alcohol
             or drugs during the study period.

         15. Who needs to use prohibited concomitant drugs, vitamins, or foods listed in the table
             of prohibited concomitant drugs and foods, and the participant who has used any of
             them during the period prohibiting the concomitant use.

         16. Male participants who plans to donate sperm during the study period or up to 12 weeks
             after the end of the study.

         17. Who currently has cardiovascular, central nervous, hepatic, or hematopoietic disease,
             renal insufficiency, metabolic or endocrinological disorder, serious allergy, asthma,
             hypoxemia, hypertension, convulsions, or allergic rash.

         18. Has a disease history, examination findings, or clinical test findings related to
             safety that reasonably suggest a disease for which TAK 272 or related renin inhibitors
             in the same class, itraconazole, digoxin, or midazolam is contraindicated or a disease
             that may affect the study conduct (which includes, for example, peptic ulcer disease,
             convulsive disorder, and arrhythmia).

         19. Who currently has or recently had (within the past 6 months) gastrointestinal disease
             that may affect drug absorption (malabsorption, esophageal reflux, peptic ulcer
             disease, erosive esophagitis, frequent [at least once a week] heartburn, surgical
             intervension [e.g., cholecystectomy]).

         20. Has past history of cancer.

         21. Who is positive for any of the following at screening: hepatitis B virus surface
             antigen (HBs), antibody against hepatitis C virus (HCV), human immunodeficiency virus
             (HIV) antigen, anti-HIV antibody, or serological tests for syphilis.

         22. The participant with difficulty having blood collected from a peripheral vein.

         23. Who has donated 200 milliliter (mL) or more whole blood within the 4 weeks (28 days)
             or 400 mL or more whole blood within the 12 weeks (84 days) before starting the study
             drug administration.

         24. Who has donated a total of 800 mL or more of whole blood within the 52 weeks (364
             days) before the day of starting the study drug administration.

         25. Who has donated blood components within the 2 weeks (14 days) before starting the
             study drug administration.

         26. Who shows clinically significant abnormalities in electrocardiogram at screening or
             before the study drug administration.

         27. Who shows laboratory test abnormalities suggestive of a clinically significant primary
             disease or who shows abnormal values in any of the following parameters at screening
             or before the study drug administration: alanine aminotransferase (ALT) and/or
             aspartate aminotransferase (AST) exceeding 1.5 times the upper limit of the normal
             range.

         28. Who is unlikely to comply with the study protocol or is ineligible for the study for
             any other reason, as considered by the investigator or sub investigator.

         29. Who had systolic blood pressure under 80 millimeter of mercury(mmHg) at Screening,
             pretreatment examination, and before the start of study drug administration, and who
             had suspected hypotension with 2 or more of the following symptoms and findings
             through physical examinations: dizziness postural, facial pallor, cold sweat.