To Assess Safety and Effect of Olaparib on the Pharmacokinetics of Anastrozole, Letrozole & Tamoxifen, and Their Effect on Olaparib, in Patients With Advanced Solid Cancer
Condition: Solid Tumours
Intervention: Olaparib; Tamoxifen; Anastrozole; Letrozole; Pharmacokinetic sampling
Intervention description: 2 x 150mg tablets, twice daily Day 1-5, and Day 27 onwards (Cohort 1), Day 20 onwards (Cohort 2) or Day 39 onwards (Cohort 3); 60mg Tamoxifen once daily, Day 10 - Day 13; 20mg Tamoxifen once daily, Day 14 - Day 31; 1mg Anastrozole once daily Day 10 - Day 24; 2.5mg Letrozole once daily Day 10 - Day 43; Blood sampling over 12-24 hour period for pharmacokinetic analysis
Intervention MeSH terms: Tamoxifen; Letrozole; Olaparib; Anastrozole
Phase: Phase 1
Study type: Interventional
Primary purpose: Basic Science
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 79.0
Sex: All
Minimum age: 18 Years
Maximum age: 130 Years
Healthy volunteers: No
Keywords: oncology, cancer, tumour, neoplasm, anticancer drug, pharmacokinetics, olaparib, anastrozole, tamoxifen, letrozole,

Summary:

      This is an open-label 2-part Phase I study in patients with advanced solid tumours. Part A of
      the study (mandatory) will assess the effect of olaparib on the pharmacokinetics (PK) of
      anastrozole, letrozole and tamoxifen and vice versa; Part B will allow patients (if eligible)
      continued access to olaparib after the PK phase and will provide additional safety data.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Provision of written informed consent prior to any study specific procedures

          2. Male or female aged ≥18 years

          3. Histological or cytological confirmation of any malignant solid tumour in an advanced
             or metastatic setting who meet one of the criteria below:

               -  Patients should be resistant or refractory to standard treatment if such
                  treatment exists OR

               -  Patients for which no suitable effective standard therapy exists OR

               -  Patients with advanced breast cancer for whom anastrozole, letrozole or tamoxifen
                  are indicated may also enter the study (postmenopausal breast cancer patients
                  will be eligible for any of the cohorts; however, premenopausal breast cancer
                  patients will be eligible for the tamoxifen cohort only).

          4. Patients must have normal organ and bone marrow function measured within 28 days prior
             to administration of study treatment as defined below:

               -  Haemoglobin (Hb) ≥10.0 g/dL with no blood transfusions in the past 28 days

               -  Absolute neutrophil count (ANC) ≥1.5 x 109/L

               -  Platelet count ≥100 x 109/L

               -  Total bilirubin ≤1.5 x institutional upper limit of normal (ULN) (except in the
                  case of Gilbert's disease)

               -  Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ≤2.5 x
                  institutional ULN unless liver metastases are present, in which case they must be
                  ≤5x ULN

               -  Serum creatinine ≤1.5 x institutional ULN

          5. Eastern Cooperative Oncology Group (ECOG) performance status 0, 1 or 2

          6. Patients must have a life expectancy ≥16 weeks

          7. Evidence of non-childbearing status for women of childbearing potential, or
             postmenopausal status: negative urine or serum pregnancy test within 28 days of study
             treatment, confirmed prior to treatment on Day 1 of Part A.

             Postmenopausal is defined as:

               -  Age ≥ 60 years

               -  Age <60 years and amenorrheic for 1 year or more in the absence of chemotherapy
                  and/or hormonal treatment

               -  Luteinising hormone (LH), follicle stimulating hormone (FSH) and plasma
                  oestradiol levels in the postmenopausal range for women under 60 years

               -  Radiation-induced oophorectomy with last menses >1 year ago

               -  Or surgical sterilisation (bilateral oophorectomy or hysterectomy)

          8. Patients are willing and able to comply with the protocol for the duration of the
             study including undergoing treatment, and scheduled visits and examinations

          9. Patients must be on stable concomitant medication regimen (with the exception of
             electrolyte supplements), defined as no change in medication or dose within 2 weeks
             prior to start of study treatment.

        Exclusion Criteria:

          1. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca
             staff, its agents, and/or staff at the study site)

          2. Previous enrolment in the present study

          3. Exposure to an investigational product (IP) (including PARP inhibitor) within 30 days
             or 5 half lives (whichever is the longer) prior to enrolment

          4. Prior chemotherapy within 3 weeks of study entry

          5. Prior radiotherapy within 2 weeks of study entry

          6. If prior endocrine treatment is given, adequate washout period is required: at least 2
             weeks for anastrozole, at least 4 weeks for letrozole and at least 10 weeks for
             tamoxifen

          7. Resting ECG with QTc >470 msec detected on 2 or more time points within a 24 hour
             period, or family history of long QT syndrome. If ECG demonstrates QTc >470 msec,
             patient will be eligible only if repeat ECG demonstrates QTc <470 msec.

          8. Patients who are receiving inhibitors or inducers of CYP3A4 unless washed out prior to
             start of study treatment.

          9. Persistent toxicities (Common Toxicity Criteria for Adverse Events [CTCAE] grade ≥2)
             caused by previous cancer therapy, excluding alopecia and/or CTCAE grade 2 peripheral
             neuropathy

         10. Patients with myelodysplastic syndrome/acute myeloid leukaemia

         11. Major surgery within 2 weeks of starting study treatment: patients must have recovered
             from any effects of any major surgery

         12. Patients considered a poor medical risk due to a serious, uncontrolled medical
             disorder, non-malignant systemic disease or active, uncontrolled seizures or active
             uncontrolled infection.

         13. Patients unable to swallow orally administered medication and patients with
             gastrointestinal disorders or significant gastrointestinal resection likely to
             interfere with absorption of the study medication

         14. Patients who have gastric, gastro-oesophageal, or oesophageal cancer

         15. Pregnant or breastfeeding women

         16. Patients with known active Hepatitis B or C, or human immunodeficiency virus (HIV).

         17. Patients with a known hypersensitivity to olaparib (all cohorts), tamoxifen (Cohort 1)
             anastrozole (Cohort 2), letrozole (Cohort 3), or any of the excipients of these
             products.