A Relative Bioavailability Study of Quinine Sulfate Capsules 324mg
Condition: Healthy
Intervention: Quinine Sulfate 2 x 324 mg Capsules; Quinine Sulfate 2 x 324 mg Capsules
Intervention description: Quinine Sulfate (2 x 324 mg capsules) administered after an overnight fast of at least 10 hours.; Quinine Sulfate (2 x 324 mg capsules) administered 30 minutes after a standardized, high fat breakfast.
Intervention MeSH terms: Quinine
Phase: Phase 1
Study type: Interventional
Primary purpose: Basic Science
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Enrollment: 22.0
Sex: All
Minimum age: 18 Years
Maximum age: 45 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Bioavailability

Summary:

      The purpose of this study is to evaluate and compare the relative bioavailability of Quinine
      Sulfate capsules following a single, oral dose in healthy volunteers under fasting and fed
      conditions.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Screening Demographics: All volunteers selected for this study will be healthy men and
             women 18 to 45 years of age at the time of dosing. Weight range will not exceed ±20%
             for height and body frame

          -  Screening Procedures: Each volunteer will complete the screening process within 28
             days prior to Period I dosing. Consent documents for both the screening evaluation and
             human immunodeficiency virus (HIV) antibody determination will be reviewed, discussed,
             and signed by each potential participant before full implementation of screening
             procedures

          -  Screening will include general observations, physical examination, demographics,
             medical history, an electrocardiogram, sitting blood pressure and heart rate,
             respiratory rate and temperature. The physical examination will include, but may not
             be limited to, an evaluation of the cardiovascular, gastrointestinal, respiratory and
             central nervous systems

          -  Screening Procedures:

          -  Hematology: hematocrit, hemoglobin, white blood cell (WBC) count with differential,
             red blood cell (RBC) count, platelet count

          -  Clinical chemistry: serum creatinine, blood urea nitrogen (BUN), glucose, AST(SGOT -
             Serum glutamic-oxaloacetic transaminase), ALT(SGPT - Serum glutamic-pyruvic
             transaminase), albumin, total bilirubin, total protein, and alkaline phosphatase

          -  HIV antibody, hepatitis B surface antigen, hepatitis C antibody screens

          -  Urinalysis: by dipstick; full microscopic examination if dipstick positive; and

          -  Urine drug screen: ethyl alcohol, amphetamines, barbiturates, benzodiazepines,
             cannabinoids, cocaine metabolites, opiates and phencyclidine

          -  Serum pregnancy screen (female volunteers only)

          -  If female and:

          -  of childbearing potential, is practicing an acceptable method of birth control for the
             duration of the study as judged by the investigator(s), such as condom with
             spermicide, diaphragm with spermicide, intrauterine device (IUD), or abstinence; or

          -  is postmenopausal for at least 1 year; or

          -  is surgically sterile (bilateral tubal ligation, bilateral oophorectomy, or
             hysterectomy).

        Exclusion Criteria:

          -  Volunteers with a recent history of drug or alcohol addiction or abuse

          -  Volunteers with a presence of a clinically significant disorder involving the
             cardiovascular, respiratory, renal, gastrointestinal, immunologic, hematologic,
             endocrine, or neurologic system(s) or psychiatric disease (as determined by clinical
             investigators)

          -  Volunteers whose clinical laboratory test values are outside the accepted reference
             range and when confirmed on re-examination are deemed to be clinically significant

          -  Volunteers demonstrating a reactive screen for hepatitis B surface antigen, hepatitis
             C antibody or HIV antibody

          -  Volunteers demonstrating a positive drug abuse screen when screened

          -  Female volunteers demonstrating a positive pregnancy screen

          -  Female volunteers who are currently breastfeeding

          -  Volunteers with a history of allergic response(s) to quinine or related drugs

          -  Volunteers with a history of clinically significant allergies including drug allergies

          -  Volunteers with a clinically significant illness during the last 4 weeks prior to
             Period I dosing (as determined by the clinical investigators)

          -  Volunteers who report donating greater than 150 mL of blood within 28 days prior to
             Period I dosing. All subjects will be advised not to donate blood for four weeks after
             completing the study

          -  Volunteers who have donated plasma (e.g. plasmapheresis) within 14 days prior to
             Period I dosing. All subjects will be advised not to donate plasma for four weeks
             after completing the study

          -  Volunteers who report receiving any investigational drug within 28 days prior to
             Period I dosing

          -  Volunteers who report taking any systemic prescription medication in the 14 days prior
             to Period I dosing

          -  Volunteers who currently use tobacco products

          -  Volunteers who have taken any drug known to induce or inhibit hepatic drug metabolism
             in the 28 days prior to Period I dosing

          -  Male volunteers with a corrected QT interval (QTc)> 430 milliseconds (msec)on the
             screening electrocardiogram (ECG) or with clinically significant findings

          -  Female volunteers with a QTC> 450 msec on the screening ECG or with clinically
             significant findings