Effect of Number of Remote Limb Ischemic Conditioning Cycles on Learning Enhancement
Condition: Healthy, Young Adults
MeSH terms: Ischemia
Intervention: RLIC - 5 cycles; RLIC - 4 Cycles; RLIC - 3 Cycles; Sham conditioning; Balance training; Arm training; Sequence production training
Intervention description: RLIC is achieved as listed in the arm/group descriptions. RLIC is performed on visits 1-7, which occur on consecutive weekdays.; RLIC is achieved as listed in the arm/group descriptions. RLIC is performed on visits 1-7, which occur on consecutive weekdays.; RLIC is achieved as listed in the arm/group descriptions. RLIC is performed on visits 1-7, which occur on consecutive weekdays.; Sham conditioning is achieved as listed in the arm/group descriptions. Sham conditioning is performed on visits 1-7, which occur on consecutive weekdays.; All participants undergo training on a balance board, learning to hold the board level with equal weight on each leg. Participants perform the balance task for 15, 30-second trials per day at visits 3-7.; All participants undergo training on a cup stacking task, learning to assemble and disassemble cup configurations as fast as they can. Participants perform the cup stacking task 5 trials per day at visits 3-7.; All participants undergo training on a discrete sequence production task. Participants learn to associate specific color and shape symbols with sequences of key presses on a keyboard. Participants perform the sequence production task for 10-15 minutes per day at visits 3-7.
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Single blinded, randomized controlled trial
Masking: Single (Participant)
Masking description: Participants will be masked to their group assignment (RLIC or Sham conditioning) throughout the study. Participants will intuitively know the dose (number of cycles) of their assignment.
Enrollment: 40.0
Sex: All
Minimum age: 18 Years
Maximum age: 40 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: ischemic conditioning, motor learning

Summary:

      The purpose of this research study is to determine the effect of number of remote limb
      ischemic conditioning (RLIC) cycles on enhancing learning in neurologically intact young
      adults.
    

Eligibility criteria:

        Inclusion Criteria:

        1. Between the age of 18 and 40 years

        Exclusion Criteria:

          1. History of neurological condition (i.e. stroke, Alzheimer's disease, Parkinson's
             disease), ADD, ADHD, balance impairment, or vestibular disorder

          2. History of sleep apnea

          3. History of lower extremity condition, injury, or surgery which could compromise
             performance on motor training task

          4. Any extremity soft tissue, orthopedic, or vascular injury (i.e. peripheral vascular
             disease) which may contraindicate RLIC

          5. Any cognitive, sensory, or communication problem that would prevent completion of the
             study

          6. Current intensive weight lifting or interval training exercise

          7. Current substance abuse or dependence

          8. Current use of medication with selective serotonin-reuptake inhibitors.

          9. Unwillingness to travel for all study visits