A Study of Pharmacokinetic Drug Interaction Study of the Hedgehog Pathway Inhibitor GDC-0449 in Combination With Rosiglitazone or Combined Oral Contraceptive in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists
Condition: Solid Cancers
Intervention: Vismodegib; Rosiglitazone; Norethindrone/ethinyl estradiol
Intervention description: Vismodegib was supplied in hard gelatin capsules.; Rosiglitazone was supplied in tablets.; Norethindrone/ethinyl estradiol was supplied in tablets.
Intervention MeSH terms: Rosiglitazone; Ethinyl Estradiol; Norethindrone; Norethindrone Acetate; Estradiol
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 52.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This is a single-arm, multicenter, Phase Ib study designed to describe the effect of GDC-0449
      on the pharmacokinetics of rosiglitazone and oral contraceptives in patients with advanced
      solid tumors who are refractory to treatment or for whom no standard therapy exists.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Histologic documentation of incurable, locally advanced, or metastatic solid
             malignancy that has failed to respond to at least one prior regimen or for which there
             is no standard therapy

          -  Documented negative serum pregnancy test for women of childbearing potential and use
             of two forms of contraception. Contraception must be used while the patient is
             enrolled in the study and for 12 months after the patient discontinues from the study.

          -  For men with female partners of childbearing potential, agreement to use a latex
             condom and to advise their female partner to use an additional method of contraception
             during the study and for 3 months after their last dose of GDC-0449.

          -  Agreement not to donate blood or blood products during the study and for at least 12
             months after their last dose of GDC-0449

          -  For male patients, agreement not to donate sperm during the study and for at least 3
             months after their last dose of GDC-0449

          -  Adequate hematopoietic capacity

          -  Adequate renal function

          -  Adequate hepatic function

          -  At least 3 weeks since the patient's last chemotherapy, investigational agent,
             radiation therapy, or major surgical procedure and recovery to pre-treatment baseline
             or stabilization of all treatment-related toxicities

        Exclusion Criteria:

          -  Active infection requiring intravenous (IV) antibiotics

          -  Clinically important history of liver disease significantly impairing hepatic
             function, including active viral or other hepatitis, current alcohol abuse, or
             cirrhosis

          -  Any medical condition or diagnosis that would likely impair absorption of an orally
             administered drug

          -  Pregnant or lactating

          -  Treatment with excluded medications, including strong CYP450 inhibitors and inducers,
             within 2 weeks of study entry

          -  Male patients already receiving rosiglitazone

          -  Male patients with a known contraindication to rosiglitazone

          -  Female patients already receiving oral contraception < 14 days prior to Day 1

          -  Female patients with known contraindication to oral contraceptions