Study of E7389 Administered Once Every 3 Weeks In Patients With Advanced Solid Tumors
Condition: Cancer
Intervention: E7389
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 21.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Cancer, tumors

Summary:

      The malignancies (advanced solid tumors) that have been chosen for evaluation of E7389 are
      those where E7389 has demonstrated significant pre-clinical anti-tumor activity, both in
      vitro and in vivo. The ultimate goal is to demonstrate the clinical activity of E7389 in the
      treatment of these, and potentially other, tumor types.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Patients must have a histologically or cytologically confirmed and measurable advanced
             solid tumor that has progressed following standard therapy or for which no standard
             therapy exists (including surgery or radiation therapy)

          -  Patients may have received prior chemotherapy (limit of two prior chemotherapy
             regimens)

          -  Patients must be aged >= 18 years

          -  Patients must have a Karnofsky Performance Status of > 70% -- Patients must have a
             life expectancy of > 3 months

          -  Patients must have adequate renal function as evidenced by serum creatinine <1.5 mg/dL
             or creatinine clearance > 60 mL/minute

          -  Patients must have adequate bone marrow function as evidenced by absolute neutrophil
             count > 1,500/µL and platelets > 100,000/µL

          -  Patients must have adequate liver function as evidenced by bilirubin < 1.5 mg/dL and
             alanine transaminase (ALAT) and aspartate transaminase (ASAT) < 2 times the upper
             limits of normal

          -  Patients must be willing and able to comply with the study protocol for the duration
             of the study

          -  Patients must give written informed consent prior to any study-specific screening
             procedures with the understanding that the patient may withdraw consent at any time
             without prejudice.

        Exclusion Criteria:

          -  Patients who have received chemotherapy within three weeks (six weeks if nitrosoureas
             were received) of E7389 treatment start

          -  Patients who have not recovered from any chemotherapy related or other therapy related
             toxicity at study entry

          -  Patients who require therapeutic doses of anti-coagulant therapy (eg, Coumadin,
             heparin, low molecular weight heparin). Low doses of anticoagulants used for patency
             (e.g., lines, catheters, ports) are permitted.

          -  Women who are pregnant or breastfeeding.

          -  Women of childbearing potential with either a positive pregnancy test at Screening or
             no pregnancy test. Women of childbearing potential unless (1) surgically sterile or
             (2) using adequate measures of contraception in the opinion of the Investigator
             (postmenopausal women must be amenorrheic for at least 12 months to be considered of
             non-childbearing potential)

          -  Fertile men who are not willing to use contraception or fertile men with a female
             partner who is not willing to use contraception

          -  Patients who have not successfully completed local therapy for previously treated
             central nervous system (CNS) metastases and who have not been discontinued from
             corticosteroids for at least four weeks before starting treatment with E7389. Patients
             with asymptomatic brain metastases who have no evidence of midline shift on CT scan or
             MRI may be enrolled without initiation of local therapy for the CNS metastases. In
             this case, a repeat scan must be performed within four weeks of the original scan to
             ensure that disease progression is not occurring.

          -  Patients who have tested positive for HIV

          -  Patients with severe uncontrolled intercurrent illness/infection (excluding
             malignancies)

          -  Patients with cardiovascular impairment

          -  Patients with organ allografts

          -  Patients who have received investigational drugs, including immunotherapy, gene
             therapy, hormone therapy, or other biologic therapy; anti-neoplastic therapy; or
             radiation therapy (other than required for palliation) within three weeks of E7389
             treatment start

          -  Patients who have had major surgery within four weeks of E7389 treatment start without
             a full recovery

          -  Patients with a hypersensitivity to Halichondrin B and/or Halichondrin B-like
             compounds Patients with other significant disease that, in the Investigator's opinion,
             would exclude the patient from the study