Study of the Gut Hormone Analogue G3215 in Adult Subjects
Condition: Diabetes Mellitus; Obesity
MeSH terms: Diabetes Mellitus
Intervention: G3215; Placebo
Intervention description: Gut hormone analogue; 0.9% saline
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Enrollment: 90.0
Sex: Male
Minimum age: 18 Years
Maximum age: 60 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: obesity; diabetes mellitus; glucagon-like peptide-1

Summary:

      A randomised, placebo controlled Phase I study to investigate the safety, tolerability,
      pharmacokinetics and pharmacodynamics of G3215 in adult subjects.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Adult males aged 18 to 60 years inclusive with body mass index (BMI) between 25.0 and
             35.0 kg/m2 inclusive;

          2. Subjects who are otherwise healthy enough to participate, as determined by pre-study
             medical history, physical examination and 12 lead ECG;

          3. Subjects whose clinical laboratory test results are either within the normal range or
             if outside this range the abnormalities are judged to be not clinically relevant and
             are acceptable to the Investigator;

          4. Subjects who are negative for hepatitis B surface antigen (HBsAg), hepatitis C
             antibody and human immunodeficiency virus (HIV) I and II tests at screening;

          5. Subjects who are negative for drugs of abuse and alcohol tests at screening and
             admissions;

          6. Subjects who are non-smokers for at least 3 months preceding screening;

          7. Subjects who agree to use medically acceptable methods of contraception for at least 3
             months after study drug administration;

          8. Subjects who are able and willing to give written informed consent.

        Exclusion Criteria:

          1. Subjects who do not conform to the above inclusion criteria;

          2. Subjects who have a clinically relevant history or presence of gastrointestinal
             (especially associated with vomiting), respiratory, renal, hepatic, haematological,
             lymphatic, neurological (especially if associated with balance disorders or vomiting
             e.g. migraine or labyrinthitis), cardiovascular, psychiatric, musculoskeletal,
             genitourinary, immunological, dermatological, connective tissue diseases or disorders;

          3. Subjects who have a clinically relevant surgical history;

          4. Subjects who are currently taking thiazolidinediones, dipeptidyl peptidase IV
             inhibitors ('gliptins'), glucagon-like peptide-1 (GLP-1) analogues, sodium-glucose
             co-transporter (SGLT-2) inhibitors, and insulin;

          5. Subjects who have a history of relevant and severe atopy e.g. asthma, angioedema
             requiring emergency treatment, severe hayfever requiring regular treatment, severe
             eczema requiring regular treatment;

          6. Subjects who have a history of relevant drug hypersensitivity;

          7. Subjects who have a history of alcohol abuse or alcohol dependence according to
             Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria
             within the last two years;

          8. Subjects who have a history of drug or substance abuse according to DSM-IV criteria
             within the last 2 years;

          9. Subjects who have a history of clinically significant migraine as judged by the
             Investigator. Subjects can be included if they have not had a migraine for the last 3
             years;

         10. Subjects with a history of pancreatitis or pancreatic cancer;

         11. Subjects who consume more than 21 units of alcohol a week (unit = 1 glass of wine (125
             mL) = 1 measure of spirits = ½ pint of beer);

         12. Subjects who have a significant infection or known inflammatory process on screening;

         13. Subjects who have acute gastrointestinal symptoms at the time of screening or
             admission (e.g. nausea, vomiting, diarrhoea, heartburn);

         14. Subjects who have an acute infection such as influenza at the time of screening or
             admission;

         15. Subjects who have used prescription drugs within 2 weeks of first dosing. For Part B,
             patients are allowed; monotherapy with sulphonylureas, or metformin. In addition
             patients in Part B are allowed to take hypolipidaemic and/or antihypertensive
             treatments, provided that the doses have not been altered within the 4 weeks prior to
             entering the study. Other medications may be allowed if the Investigator and Sponsor
             both agree that they will not affect the outcome of the study or the safety of the
             subject.

         16. Subjects who have used over the counter medication excluding routine vitamins and
             paracetamol but including megadose (intake of 20 to 600 times the recommended daily
             dose) vitamin therapy within 7 days of first dosing, unless agreed as not clinically
             relevant by the Principal Investigator and Sponsor;

         17. Subjects who have donated blood within 3 months prior to screening; Subjects who have
             donated plasma within the 7 days prior to screening; Subjects who have donated
             platelets within the 6 weeks prior to screening

         18. Subjects who have used any investigational drug in any clinical trial within 3 months
             of their first admission date;

         19. Subjects who have received the last dose of investigational drug greater than 3 months
             ago but who are on extended follow-up;

         20. Subjects who have previously received G3215;

         21. Subjects who are vegans or have any dietary restrictions;

         22. Subjects who cannot communicate reliably with the Investigator;

         23. Subjects who are unlikely to co-operate with the requirements of the study;

         24. History or evidence of abnormal eating behaviour, as observed through the Dutch Eating
             Behaviour (DEBQ) and SCOFF (Sick, Control, One Stone, Fat, Food) questionnaires at
             screening.