A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Food-Effect of KQ-791
Condition: Healthy Volunteers; Insulin Resistance
MeSH terms: Insulin Resistance
Intervention: KQ-791; KQ-791 (after meal); Placebo
Intervention description: Capsules administered orally while fasting, in up to 3 periods; Single dose of KQ-791 in capsules, after a meal, in 1 period; Capsules, administered orally, in 1 period
Phase: Phase 1
Study type: Interventional
Primary purpose: Basic Science
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Double (Participant, Investigator)
Enrollment: 19.0
Sex: All
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The purpose of this study is to assess the safety, tolerability, and the effect of food on
      KQ-791. Each participant may receive up to 3 single doses of KQ-791 (at up to 3 different
      dose levels) and 1 placebo dose over the course of the study. Up to 6 escalating dose levels
      may be studied, in two distinct groups or cohorts.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Male or non-childbearing potential female, which includes post-menopausal female
             (absence of menses for 12 months prior to drug administration, bilateral oophorectomy
             or hysterectomy with bilateral oophorectomy at least 6 months prior to drug
             administration) or surgically sterile female (hysterectomy or tubal ligation at least
             6 months prior to drug administration)

          -  Body Mass Index (BMI) greater than or equal to (≥) 27.0 and less than or equal to (≤)
             35.0 kilogram per square meter (kg/m2)

          -  Healthy as defined by:

               1. absence of clinically significant illness and surgery within last 4 weeks.
                  Participants vomiting within 24 hours pre-dose will be evaluated for upcoming
                  illness/disease

               2. the absence of clinically significant history of neurological, endocrine,
                  cardiovascular, pulmonary, hematological, immunologic, psychiatric,
                  gastrointestinal, renal, hepatic, or metabolic disease

          -  Male participants who are not vasectomized for at least 6 months, and who are sexually
             active with non-sterile female partner (sterile female partners include
             post-menopausal females and surgically sterile females) must be willing to use one of
             the following acceptable contraceptive methods throughout the study and for 90 days
             after the last study drug administration:

               1. simultaneous use of a condom, and for the female partner hormonal contraceptives
                  (used since at least 4 weeks) or intra-uterine contraceptive device (placed since
                  at least 4 weeks)

               2. simultaneous use of a male condom, and for his female partner, a diaphragm with
                  intravaginally applied spermicide

          -  Some degree of insulin resistance, as shown by:

               1. fasting blood glucose ≥95.4 and ≤126 milligrams per deciliter (mg/dL) (equivalent
                  to 5.3 to 7.0 millimoles per liter (mmol/L), respectively) and

               2. fasting triglycerides ≤ 4.0 mmol/L, and/or

               3. Low-Density Lipoprotein Cholesterol (LDL-C) ≤ 6.0 mmol/L

          -  Capable of consent

          -  Non-smoker (no use of tobacco products within the last 3 months)

        Exclusion Criteria:

          -  Any clinically significant abnormality or abnormal laboratory test results (other than
             glucose,triglycerides and LDL-C levels described in inclusion criterion)

          -  Positive test for hepatitis B, hepatitis C, or Human Immunodeficiency Virus (HIV)

          -  Evidence of clinically significant hepatic or renal impairment, including Alanine
             Aminotransferase (ALT) above 1.5x Upper Limit of Normal (ULN), Aspartate
             Aminotransferase (AST) above 2x ULN, total bilirubin above 2x ULN (total bilirubin
             accepted up to 2x ULN if direct bilirubin is within normal limits), or Estimated
             Glomerular Filtration Rate (eGFR) less than (<) 90 milliliters per minute (mL/minute)

          -  Positive urine drug screen

          -  History of significant allergic reactions (e.g. angioedema) to any drug.

          -  Use of any drugs known to induce or inhibit hepatic drug metabolism within the last 30
             days

          -  Positive pregnancy test

          -  Any reason which, in the opinion of the qualified investigator (QI) would prevent the
             subject from participating in the study

          -  Clinically significant electrocardiogram (ECG) abnormalities at screening, or
             clinically significant personal or family history (in a first-degree relative) of
             heart diseases, including:

               1. Confirmed corrected QT (QTcF) interval greater than (>) 450 milliseconds (msec)
                  for men and women

               2. Bundle branch blocks and other conduction abnormalities other than mild first
                  degree atrio-ventricular block

               3. Irregular rhythms other than sinus arrhythmia or occasional, rare
                  supraventricular ectopic beats

          -  History of unexplained syncope

          -  Family history of unexplained sudden death or sudden death due to long QT syndrome

          -  T-wave configurations are not of sufficient quality for assessing QT interval

          -  Clinically significant vital sign abnormalities (systolic blood pressure lower than 90
             or over 150 mmHg, diastolic blood pressure lower than 50 or over 95 mmHg, or heart
             rate less than 50 or over 100 beats per minute (bpm))

          -  History of significant alcohol abuse within one year prior to screening or regular use
             of alcohol within six months prior to the screening (regular use of more than three
             units of alcohol per day for males and more than two units of alcohol per day for
             females [1 unit = 150 (milliliter) mL of wine, 360 mL of beer, or 45 mL of 40%
             alcohol]) or positive alcohol breath test

          -  History of significant drug abuse within the last year or use of soft drugs (such as
             marijuana) within 3 months prior, or hard drugs (such as cocaine, phencyclidine (PCP)
             and crack) within the last year

          -  Participation in a clinical trial involving the administration of an investigational
             or marketed drug within the last 30 days (90 days for biologics) or concomitant
             participation in an investigational study

          -  Use of medication other than topical products without significant systemic absorption:

               1. prescription medication within last 14 days

               2. over-the-counter products within the last 7 days, with the exception of the
                  occasional use of acetaminophen (up to 2 grams (g) daily)

               3. natural health products (e.g. food supplements or herbal supplements) within last
                  14 days

               4. a depot injection or an implant of any drug within last 3 months

          -  Donation of plasma within the last 7 days. Donation or loss of blood of 50 mL to 499
             mL of blood within 30 days, or more than 499 mL within 56 days

          -  Hemoglobin <128 grams per liter (g/L) (males) and <115 g/L (females) and hematocrit
             <0.37 L/L (males) and <0.32 L/L (females)

          -  Breast-feeding participant