A Study in Participants With Advanced Solid Tumors
Condition: Solid Tumor
MeSH terms: Neoplasms
Intervention: Ramucirumab
Intervention description: Administered IV.
Intervention MeSH terms: Ramucirumab
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 28.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This trial is testing ramucirumab (LY3009806) administered to Chinese participants with
      advanced solid tumors that are resistant to standard therapy or for whom no standard therapy
      is available. The purpose of this study is to evaluate how safe ramucirumab is and whether it
      causes any side effects. The study will also measure how much ramucirumab gets into the blood
      stream and how long it takes the body to get rid of it.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Chinese participants with histopathologically or cytologically diagnosed advanced
             solid tumor

          -  Did not respond to standard therapy or no standard therapy is available

          -  Measurable or nonmeasurable disease according to the Response Evaluation Criteria In
             Solid Tumors (RECIST)

          -  Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1 at study
             entry

          -  Able to provide written informed consent

          -  A life expectancy of >3 months

          -  Adequate hematologic function, as defined by: Absolute neutrophil count (ANC) ≥1500
             per cubic millimeter (mm^3); hemoglobin concentration ≥9 grams per deciliter (g/dL);
             and platelet count ≥100,000/mm^3

          -  Adequate hepatic function, as defined by: Total bilirubin level ≤1.5 x the upper limit
             of normal (ULN) (in participants with known Gilbert Syndrome, a total bilirubin ≤ 3.0
             x ULN with direct bilirubin ≤ 1.5 x ULN); aspartate aminotransferase (AST) and alanine
             aminotransferase (ALT) ≤2.5 x ULN (or ≤5 x ULN if the participant has liver metastases

          -  Adequate renal function, as defined by: Serum creatinine level ≤1.5 x ULN; or
             calculated serum creatinine clearance (Cockcroft-Gault) ≥50 milliliters per minute
             (mL/min)

          -  Urinary protein is 0 or 1+ on dipstick but no edema nor serum albumin < lower level of
             normal

          -  Adequate coagulation function, as defined by: International normalized ratio (INR)
             ≤1.5, or prothrombin time (PT) ≤1.5 x ULN and activated partial thromboplastin time
             (aPTT) ≤1.5 x ULN (unless receiving anticoagulation therapy)

          -  Agrees to use adequate contraception during the study period and for 12 weeks after
             the last dose of study treatment

        Exclusion Criteria:

          -  Had chemotherapy or therapeutic radiotherapy within 14 days (6 weeks for nitrosoureas
             or mitomycin C) before entering the study or the participant has ongoing side effects
             (≥ Grade 2) due to previously administered agents

          -  Has obvious evidence of intratumor cavitation

          -  Has undergone major surgery within 28 days before study entry or has had a central
             venous access device inserted within 7 days before study entry

          -  Has a history of gastrointestinal perforation, postoperative bleeding complications,
             or wound complications from a surgical procedure

          -  Has elective or planned surgery to be conducted during the trial

          -  Has documented and/or symptomatic brain or leptomeningeal metastases

          -  Has uncontrolled ongoing illness, for example: thrombotic or hemorrhagic disorders;
             hemoptysis; ongoing infection requiring systemic antibiotic treatment; congestive
             heart failure, angina pectoris, angioplasty, stenting, or myocardial infarction within
             6 months; stroke, transient ischemic attack (TIA), or other grade 3-4 arterial
             thromboembolic event occurring within 6 months; uncontrolled hypertension (≥150/≥90
             millimeters of mercury [mmHg]); cardiac arrhythmia that requires treatment or
             asymptomatic sustained ventricular tachycardia; peripheral neuropathy ≥Grade 2; human
             immunodeficiency virus (HIV) or active, uncontrolled hepatitis, liver cirrhosis at a
             level of Child-Pugh Class B (or worse), liver cirrhosis (any degree) and a history of
             hepatic encephalopathy or clinically meaningful ascites resulting from cirrhosis.
             (Clinically meaningful ascites is defined as ascites resulting from cirrhosis and
             requiring ongoing treatment with diuretics and/or paracentesis)

          -  Has a serious or nonhealing wound, ulcer, or bone fracture within 28 days before study
             entry

          -  Has experienced any Grade 3 or 4 gastrointestinal bleeding within 3 months before
             study entry

          -  Has a history of abdominal fistula, gastrointestinal perforation, or intra-abdominal
             abscess <6 months before randomization, or the participant has a history of poorly
             controlled or recurrent inflammatory bowel disease (including Crohn's disease or
             ulcerative colitis)

          -  Has participated in a clinical study of a non-approved experimental agent or procedure
             within 4 weeks prior to study entry for small molecules, or 8 weeks before study entry
             for non-approved monoclonal antibodies

          -  Has a known allergy to ramucirumab or its excipients, a monoclonal antibody (MAb), or
             any other therapeutic protein, such as fresh frozen plasma, human serum albumin (HSA),
             cytokines, or interleukins. If there is suspicion that the participant may have an
             allergy, the participant should be excluded

          -  Is pregnant (confirmed by urine or serum pregnancy test) or lactating

          -  Has known alcohol or drug dependency

          -  Is receiving chronic therapy with nonsteroidal anti-inflammatory agents (NSAIDs)

          -  Is not considered to be suitable for this study, in the opinion of the investigator