Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Single-Dose Subcutaneous Administration of MEDI-528
Condition: Healthy
Intervention: MEDI-528 0.3 mg/kg; MEDI-528 1 mg/kg; MEDI-528 3 mg/kg; MEDI-528 9 mg/kg
Intervention description: MEDI-528 (0.3 mg/kg) administered as a single, subcutaneous (SC) dose; MEDI-528 (1 mg/kg) administered as a single, SC dose; MEDI-528 (3 mg/kg) administered as a single, SC dose; MEDI-528 (9 mg/kg) administered as a single, SC dose
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Non-Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 29.0
Sex: All
Minimum age: 19 Years
Maximum age: 49 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      A Phase I studyto evaluate the safety and tolerability of escalating subcutaneous (SC) doses
      of MEDI-528 in to healthy adult volunteers.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Males and females age 19 up to, and including, 49 years of age at the time of the
             first dose of study drug

          -  Weight less than 89 kg

          -  Written informed consent obtained from the volunteer

          -  Healthy by medical history and physical examination

          -  Sexually active females, unless surgically sterile or at least two years
             post-menopausal or an FSH≥40 mIu/mL, must use an effective method of avoiding
             pregnancy (including oral, injectable, transdermal, abstinence, use of a condom by the
             sexual partner or sterile sexual partner) for 3 months before the first dose of study
             drug, and must agree to continue using such precautions through the study period of 84
             days. Cessation of birth control after this point should be discussed with a
             responsible physician. Sexually active males, unless surgically sterile, must likewise
             use an effective method of birth control (condom or abstinence) and must agree to
             continue using such precautions through Study Day 84 after their dose of study drug.

          -  Use of common over-the-counter medications such as topical corticosteroids,
             decongestants, antihistamines, analgesics, and antacids is permitted unless, in the
             opinion of the investigator, it would interfere with either the volunteer's ability to
             complete the study or interpretation of the study results.

          -  Ability to complete the follow-up period of 84 days

          -  Willing to forego other forms of experimental treatment during the study period of 84
             days

          -  Willing to forego vigorous activity 1 - 2 days before dosing, and before each study
             visit.

        Exclusion Criteria:

          -  Acute illnesses or evidence of significant active infection, such as fever greater
             than or equal to 38.0 C (100.5°F) at the start of the study

          -  Use of prescription medications, other than oral contraceptives, in the 28-day period
             before Study Day 0

          -  Any blood donation or significant loss of blood within 6 months of time of entry into
             the study

          -  History of immunodeficiency or receipt of immunosuppressive drugs

          -  History of allergy or reaction to any component of the MEDI-528 formulation

          -  History of substance abuse that, in the opinion of the investigator, may compromise
             the ability of the study subject to complete the study and follow-up period

          -  Evidence of any systemic disease, neurologic abnormality, lymphadenopathy, or
             splenomegaly upon physical examination

          -  Evidence of infection with hepatitis A, B, or C virus or HIV-1

          -  Receipt of immunoglobulins or blood products within 60 days of entering the study

          -  Receipt of any investigational drug therapy or standard vaccine therapy, other than
             vaccination for influenza, within 60 days of the first dose of study drug through
             Study Day 84 (use of licensed agents for indications not listed in the package insert
             is permitted)

          -  Receipt of MEDI-528 in any previous clinical study

          -  At Screening (must be within 21 days before study dose administration) any of the
             following: Hgb, total WBC, platelet count, Na, K, C1, CO2, AST, ALT, BUN, glucose,
             amylase, lipase, creatinine, or troponin out of the normal range; other abnormal
             laboratory values in the screening panel that, in the opinion of the principal
             investigator, are judged to be clinically significant

          -  Clinically significant abnormality, as determined by the investigator, on 12-lead
             electrocardiogram at the time of initial screening

          -  Clinically significant abnormalities noted on baseline brain MRI

          -  Elective surgery planned during the study period through Study Day 84

          -  Pregnancy (sexually active females must have a negative serum pregnancy test on the
             day of the first dose of study drug, before dosing)

          -  Nursing mother

          -  The presence of any condition or concern which, in the opinion of the investigator,
             may interfere with the conduct or interpretation of the study.