A Study to Evaluate and Compare the Efficacy and Pharmacokinetics of MK-0873 for the Treatment of Plaque Psoriasis (MK-0873-022)
Condition: Psoriasis; Plaque Psoriasis
MeSH terms: Psoriasis
Intervention: MK-0873 2% Cream; MK-0873 vehicle (placebo) Cream; Calcitriol Cream
Intervention description: Approximately 3 to 5 mg of MK-0873 2% cream per cm^2 of body area in 2 divided applications per day for 28 days. The maximum area for one treatment will be approximately 5% of body surface area.; Approximately 3 to 5 mg matching placebo to MK-0873 2% cream per cm^2 of body area in 2 divided applications per day for 28 days. The maximum area for one treatment will be approximately 5% of body surface area.; Approximately 3 to 5 mg of Calcitriol 0.0003% (3 µg/g) per cm^2 of body area once daily for 28 days. The maximum area for one treatment will be approximately 5% of body surface area
Intervention MeSH terms: Calcitriol; MK 0873
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Enrollment: 24.0
Sex: All
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: No

Summary:

      This is a within-participant comparison study to investigate the efficacy of a 28-day regimen
      of MK-0873 2% cream twice a day (b.i.d.) compared to MK-0873 vehicle (matching placebo)
      b.i.d. as well as to a positive control comparator calcitriol 0.0003% (3 µg/g) in
      participants with plaque psoriasis. In order to be enrolled in the study, patients need to
      have at least two pairs (lesions AB and CD) of approximately similar plaque lesions in
      severity and size of surface area involved and located in approximately symmetric regions
      such as the trunk or limbs of the body. Participants will be randomly assigned to apply
      either MK-0873 or MK-0873 vehicle to plaque A or B and will be randomly assigned to apply
      MK-0873 or calcitriol to plaque C or D. It is hypothesized that MK-0873 cream formulation
      administered to participants with psoriasis by the topical route will result in a
      statistically greater percent target lesion severity (TLS) reduction in plaque lesion than
      will MK-0873 Vehicle on Day 29.
    

Eligibility criteria:

        Inclusion Criteria

          -  Is a male or female 18 to 65 years of age

          -  Female subjects of reproductive potential must have a negative serum pregnancy test at
             screening and agree to use and/or have their partner use two (2) acceptable methods of
             birth control

          -  Has a Body Mass Index (BMI) ≤36 kg/m^2 (up to 40 kg/m^2 may be enrolled, in
             consultation with Sponsor)

          -  Has diagnosis of plaque-type psoriasis at least 6 month prior to administration of
             study drug (participants with concurrent psoriatic arthritis may be enrolled)

          -  Has plaque-type psoriasis with at least two pairs of symmetrically located plaque
             lesions that exhibit similar baseline TLS values (TLS in each plaque ≥6 and

             ± 2 points difference between left and right plaque lesions)

          -  Has plaque-type psoriasis with lesion severity score ≥4 covering at least 1 to 20% of
             total body surface area at screening and at baseline.

          -  Is judged to be in good health based on medical history, physical examination, vital
             sign measurements, electrocardiogram assessment, and laboratory safety tests

        Exclusion Criteria

          -  Has nonplaque forms of psoriasis (e.g., Erythrodermic, guttate, or pustular).

          -  Has current drug-induced psoriasis (e.g., a new onset of psoriasis or an exacerbation
             of psoriasis from beta blockers, calcium channel blockers or lithium).

          -  Has received phototherapy or any systemic medications/treatments that could affect
             psoriasis or TLS evaluation (including but not limited to oral or injectable
             corticosteroids, retinoids, 1, 25-dihydroxy vitamin D3 and analogues, psoralens,
             sulfsalazine, hydroxyurea, fumaric acid derivatives, or herbal treatments) within 4
             weeks of study drug administration.

          -  Has used topical medications/treatments that could affect psoriasis or TLS evaluation
             (e.g., corticosteroids, coal tar, anthralin, calcipotriene, topical vitamin D
             derivatives, retinoids, tazarotene, methoxsalen, trimethyl psoralens) within 2 weeks
             of study drug administration.

          -  Has used any systemic immunosuppressants (e.g., Methotrexate, azathioprine,
             cyclosporine, 6-thioguanine, mercaptopurine, mycophenolate mofetil, hydroxyurea, or
             tacrolimus) within 4 weeks of study drug administration or biologics (e.g., anti-tumor
             necrosis factor [TNF], anti-interleukins) within 3 months of study drug
             administration.