Steroid Treatment for Hypereosinophilic Syndrome
Condition: Eosinophilia; Hypereosinophilic Syndrome; Leukocyte Disorder; Hematologic Diseases
MeSH terms: Hematologic Diseases; Eosinophilia; Hypereosinophilic Syndrome; Leukocyte Disorders; Syndrome
Intervention: prednisone
Intervention description: Glucocorticoids (GC) are considered the first- line therapy for hypereosinophilic syndrome.
Intervention MeSH terms: Prednisone
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 26.0
Sex: All
Minimum age: 7 Years
Maximum age: 100 Years
Healthy volunteers: No
Keywords: Hypereosinophilia; Hypereosinophilic Syndrome; Corticosteroids; Therapy; HES

Summary:

      Background:

      - Hypereosinophilic syndrome (HES) is a disorder in which the body has too many eosinophils
      (a type of white blood cell). Too many eosinophils in HES can cause damage to the heart,
      nerves, or skin. Certain drugs can help lower eosinophil counts to prevent tissue damage.
      Corticosteroids, such as prednisone, are used for initial therapy in this disorder. Although
      most people respond to prednisone, some people develop side effects from it, or do not
      respond very well to treatment. Better ways of determining the dose to give could help to
      decide on the best therapy for HES.

      Objectives:

        -  To determine whether a single-dose of prednisone can be used to predict which people
           with hypereosinophilia respond to treatment.

        -  To study lack of response to steroid treatment in people with HES.

      Eligibility:

      Inclusion criteria:

        -  Individuals with hypereosinophilic syndrome with high eosinophil counts.

        -  Individuals who are willing to have blood drawn before and after getting steroids.

      Exclusion criteria:

        -  Individuals who are on more than 10mg of prednisone (or similar drug)

        -  Individuals with hypereosinophilic syndrome who are on other medications that could
           interfere with the study

        -  Women who are pregnant or breast-feeding

        -  Individuals who have a known gene mutation associated with chronic eosinophilic leukemia

        -  Children less than 18 years old who weigh less than 48kg or 106lb

      Design:

        -  Participants will have a screening visit with a physical exam and medical history. Blood
           and urine samples will be collected.

        -  Participants will have a single dose of the steroid prednisone by mouth in the morning.
           Blood samples will be collected 2, 4, 24 hours after this dose.

        -  On the day after the steroid dose, participants will provide another blood sample in the
           morning.

        -  Participants will start to take prednisone daily when they return home. Blood samples
           will be collected weekly at the participant s doctor s office. The dose of prednisone
           will be lowered depending on the weekly eosinophil count. We will try to get each person
           on the lowest dose of prednisone possible that will control the disorder. Participants
           who do not respond or have severe side effects will be taken off prednisone. Other
           treatments will be considered for people who do not respond to steroids. The goal is to
           evaluate the response to prednisone. Our research will try to figure out why some people
           do not respond to steroids. Most people will complete the study within 6 to 16 weeks,
           depending on their response to prednisone.
    

Eligibility criteria:

        -  SUBJECT INCLUSION CRITERIA:

        Subjects on Protocol #94-I-0079 will be eligible for participation in the study only if all
        of the following criteria apply:

          1. Subjects must be 7 years of age or older to enroll

          2. Subject meets diagnostic criteria for HES (AEC >1500/microL, absence of a secondary
             cause and signs and/or symptoms attributable to the eosinophilia)

          3. AEC greater than 1500 microL obtained within 14 days prior to enrollment

          4. Willingness to perform the timed steroid challenge

          5. Appropriate candidate for GC treatment after challenge

          6. Willingness to have samples stored for future research

        SUBJECT EXCLUSION CRITERIA:

        A subject will not be eligible to participate in the study if any of the following apply:

          1. Receiving >10 mg prednisone or equivalent at the time of enrollment.

          2. Receiving less than or equal to 10 mg of prednisone or equivalent but have not been on
             a fixed dose for at least 3 weeks (subjects on a current corticosteroid taper will be
             excluded).

          3. AEC less than or equal to 1500/microl on the day of the steroid challenge

          4. Use of immunomodulatory medications, (other than less than or equal to 10 mg/day
             prednisone) including but not limited to biologics, within the past 6 months.

          5. Pregnant at the time of screening.

          6. Have a known mutation in the FIP1L1-PDGFR gene.

          7. Any condition that, in the opinion of the investigator, places the subject at undue
             risk by participating in the protocol.

          8. Weight less than 48 kg (106 lbs) in subjects less than 18 years of age.