Evaluate the Efficacy and Safety Growth Hormone, Glutamine and Diet in Patients With Short Bowel Syndrome (SBS)
Condition: Short Bowel Syndrome
MeSH terms: Short Bowel Syndrome; Syndrome
Intervention: Growth Hormone
Intervention description: dosage = 0.05mg/kg/day, in diluent for injection, once a day, for 23 - 54 days.
Intervention MeSH terms: Hormones
Phase: Phase 4
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 5.0
Sex: All
Minimum age: 19 Years
Maximum age: 78 Years
Healthy volunteers: No
Keywords: Growth Hormone; TPN; Total Parenteral Nutrition; Glutamine; Short Bowel Syndrome; Increase in absorption of small bowel.

Summary:

      Treatment for 3.5-8 weeks with GH (0.05 mg/kg/day) +GLN+Diet, followed by continued
      compliance to the individualized oral diet and enteral GLN, will result in reduced volume of
      TPN infusion/week and/or reduced frequency of TPN infusions/week.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Be male or female between 19 and 78 years of age, inclusive

          -  Have a diagnosis of SBS and 1 or more of the following characteristics:

          -  Dependent upon TPN and/or IV fluids

          -  Unable to receive TPN because of a documented history of complications associated with
             the long-term parenteral infusions (e.g. lack of venous access, multiple septic
             events, progressive liver dysfunction while on TPN, etc)

          -  A documented remnant bowel anatomy that is inconsistent with adequately supporting
             life without parenteral support (e.g. < 70 cm of healthy small intestine and a portion
             of colon, or less than 150 cm in patients with no colon)

          -  A documented history of diarrhea and/or malabsorption that has significantly
             compromised the patient's nutritional and hydration status (e.g. significant weight
             loss - 5% over 1 month or 10% over 6 months, or a serum albumin < 3.5 g/dl, documented
             nutrient deficiencies, documented episodes of dehydration, etc).

          -  Is able to eat at least some (>500 calories) of solid food on a regular basis or
             tolerate at least some (>500 calories) of an enteral feeding formula

          -  Have stable liver and renal function

          -  For patients with known hypertension and other cardiovascular disorders, be both
             compensated and stabilized on a regular therapeutic regimen

          -  For women participating in the study, manifest or give assent to 1 of the following
             criteria to ensure that the patient does not become pregnant during the study:

          -  The patient must be surgically sterile or demonstrably postmenopausal.

          -  Any patient capable of becoming pregnant must have a negative urine pregnancy test and
             must agree to practice a method of contraception documented to have at least 90%
             reliability throughout the treatment period.

          -  Have the ability to understand the requirements of the study, to provide written
             Informed Consent, and to abide by the study restrictions and agree to complete the
             required assessments in the Follow-up Period

        Exclusion Criteria:

          -  Be pregnant or lactating

          -  Have a history of mental deficiency or illness that might compromise compliance with
             the requirements of the study

          -  Have clinically serious neurological dysfunction

          -  Have hypoxemic pulmonary diseases (i.e., resting pAO2 < 75 torr)

          -  Have unstable ischemic heart disease or uncompensated cardiac failure

          -  Have participated in any study involving an investigations drug within 30 days prior
             to entry into this trial.