Wearing-Off Period of Pharmacological Dilation and Anisocoria
Condition: Anisocoria
MeSH terms: Anisocoria
Intervention: Tropicamide; 1% Pilocarpine; Proparacaine Hydrochloride; Tono pen AVIA; VG4 Gonio; Reichert phoropter
Intervention description: One drop will be given to participants; One drop will be given to participants; One drop will be given to participants; Participant intraocular pressures measured; Participant iridocorneal angle measured; Participant screened for hyperopia >+1 diopter
Intervention MeSH terms: Proxymetacaine; Pilocarpine; Tropicamide
Phase: Phase 4
Study type: Interventional
Primary purpose: Health Services Research
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 11.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      Students at the School of Medicine Greenville will be asked to participate in this study.

      The aim of this study is to better understand when medical imaging is needed for patients
      with anisocoria (unequal pupil size).

      Participation in the study includes up to 3 visits over a period of one week. Each study
      visit will last about 30 minutes.

      At the first visit, participants will be screened for hyperopia using a phoropter, have their
      intraocular pressures taken using a tono-pen, and have their iridocorneal angle measured
      using gonioscopy at the ophthalmology clinic. Proparacaine hydrochloride 0.5% eye drops will
      be used to numb the eyes before measuring intraocular pressures and prior to gonio lens exam.
      Participants will also be asked to complete three forms.

      Participants will be asked to return to the clinic on a scheduled day within one week of the
      screening visit to have their left eye dilated. At this visit, the diameter of the pupil will
      be measured using a Near card in a windowless room with a set light-level. Then, the
      participant will receive one drop of tropicamide in the left eye. After the drops have had
      time to take effect, which will be about 20-30 minutes later, the diameter of the pupil will
      be measured again.

      Participants will then be asked to return to the clinic in 3-4 hours. At this time, the
      diameter of the pupil will be measured again.

      The third type of eye drop used in this study is 1% pilocarpine. 1 % pilocarpine will briefly
      constrict the eyes. One drop of 1% pilocarpine will be administered to left eye, and the
      change in pupillary diameter will be measured, if any. It will take about 10-15 minutes for
      the 1% pilocarpine to take effect.

      Participants may be required to attend 2 additional 30-minute visits on a third day depending
      on how their eyes respond to the drops.

      This study will recruit about 10-15 participants.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Student at the University of South Carolina School of Medicine Greenville

          -  Healthy participants

          -  No significant ophthalmological history

        Exclusion Criteria:

          -  a history of angle closure glaucoma, any other type of glaucoma

          -  any elevated eye pressure readings

          -  any history of intraocular surgery or procedure.

          -  if the participant is found to be hyperopic to >+1 diopter, has an intraocular
             pressure of > 22 mm Hg in either eye, or displays an iridocorneal angle where
             trabecular meshwork

          -  known allergy to natural rubber latex