Nailfold Capillary Blood Flow With Latanoprost Bunod
Condition: Glaucoma, Open-Angle
MeSH terms: Glaucoma, Open-Angle
Intervention: Latanoprost 0.005%; Latanoprost bunod 0.024%; Normal saline 0.9%; Nailfold capillaroscopy
Intervention description: Latanoprost 0.005% will be applied to the nailfold and images of the blood flow in the nailfold capillaries will be acquired.; Latanoprost bunod 0.024% will be applied to the nailfold and images of the blood flow in the nailfold capillaries will be acquired.; Normal saline 0.9% will be applied to the nailfold and images of the blood flow in the nailfold capillaries will be acquired.; An imaging system and does not penetrate the skin. A video camera with a magnifying lens used for studying the movement of blood in small blood vessels at the nailfold of the 4th finger.
Intervention MeSH terms: Latanoprost
Phase: Phase 4
Study type: Interventional
Primary purpose: Basic Science
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Masking description: Patients will have baseline NFC blood flow measurements after application of cedar oil. Then the study team will use NF application of either normal saline, latanoprost 0.005% or LTB 0.024% in random sequence. The patient and imager will know which study article is applied. NFC blood flow will be remeasured after 15 minutes. Preliminary data on controls suggests that 15 minutes is sufficient time to see a change in blood flow. NF article application will occur on a specially designed well applied to the 4th digit of the non-dominant hand. Two masked observers will evaluate NFC blood flow.
Enrollment: 47.0
Sex: All
Minimum age: 40 Years
Maximum age: 80 Years
Healthy volunteers: No
Keywords: Nailfold capillary imaging; Latanoprost bunod; Latanoprost

Summary:

      The purpose of this study is to look at the relationship of small blood vessels
      irregularities observed with an imaging system called video nailfold capillaroscopy in people
      with primary open-angle glaucoma. Nailfold capillaroscopy (NFC) is a video camera with a
      magnifying lens used for studying the movement of blood in small blood vessels. It is simple,
      safe and does not penetrate the skin. The skin fold that is at the tip of the finger is
      called the "nailfold". NFC has been used to assess blood vessel narrowing in patients with
      glaucoma.
    

Eligibility criteria:

        Inclusion Criteria:

          -  40 years old to 80 years old

          -  All participants will have open angles and no signs of secondary glaucoma such as
             exfoliation syndrome

          -  Untreated intraocular pressure (IOP) may be ≤ 21mmHg or ≥ 21mmHg in both eyes

          -  The cup-to-disc ratio (CDR) ≥ 0.6 in both eyes and CDR asymmetry ≤ 0.2.

          -  POAG patients will have reliable Humphrey Visual Field (HVF) loss consistent with
             optic nerve damage

          -  POAG patients can have any stage of POAG and be on any form of treatment for their
             disease.

          -  Willingness to sign informed consent and comply with study procedures.

        Exclusion Criteria:

          -  History of non-POAG forms of glaucoma

          -  Pregnancy

          -  Inability to give informed consent