Homeopathic Treatment of Post-acute COVID-19 Syndrome
Condition: Post-acute Covid-19 Syndrome
MeSH terms: COVID-19; Post-Acute COVID-19 Syndrome; Syndrome
Intervention: Homeopathic Medication; Placebo
Intervention description: Homeopathic medicines are prepared according to standardized methods as specified by the Homeopathic Pharmacopoeia of the United States (HPUS), which was mandated by Congress to regulate the manufacture of homeopathic medicines as part of the Food, Drug, and Cosmetics Act of 1939. All homeopathic medicines prescribed in this study must be found in the HPUS. For a complete list of homeopathic medicines, contact the researchers.; Inert lactose pellets
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Intervention model description: Randomized, double-blind, placebo-controlled clinical trial
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Masking description: Both study medication and placebo are identical in appearance, odor, and taste. Statistician will be blinded as to treatment group.
Enrollment: 77.0
Sex: All
Minimum age: 18 Years
Maximum age: 64 Years
Healthy volunteers: No
Keywords: Long Covid

Summary:

      To determine whether an individually prescribed homeopathic medicine has an effect greater
      than a placebo and is a viable treatment option to improve fatigue and quality of life for
      patients suffering from the symptoms of Post-acute COVID-19 Syndrome. The researchers hope to
      achieve this goal by conducting a clinical trial that is scientifically rigorous and
      clinically relevant. Expected results of this pilot study will be to obtain sufficient
      experience and preliminary feasibility data to justify a larger clinical trial of this
      hypothesis.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Ages 18-64

          -  Any ethnicity

          -  Adequate cognitive function to be able to give informed consent

          -  Technologically competent to complete web forms and perform video calls

          -  Positive PCR test (polymerase chain reaction) result for SARS-CoV-2 (severe acute
             respiratory syndrome coronavirus 2)

          -  Persistent fatigue for a minimum of 60 days since diagnosis of Covid-19.

          -  A fatigue score above 21 in the Fatigue Assessment Scale upon enrollment

          -  Willing to fill out regular questionnaires

          -  Willing to use homeopathic medicines

        Exclusion Criteria:

          -  Clinically significant kidney, heart, or hepatic impairment as determined by clinical
             judgment

               -  Previous hospitalization in ICU for Covid-19

               -  Diagnosis of Chronic Fatigue Syndrome, Fibromyalgia, or Lyme disease prior to
                  Covid-19

               -  Chronic psychiatric illness or neurological illness prior to Covid-19 diagnosis
                  Taking opioid analgesics, opioid dependence or undergoing treatment for substance
                  abuse or addiction

               -  Taking steroid medication or immunosuppressive medications

               -  Suspected or confirmed pregnancy or breastfeeding

               -  Active cancers

               -  Current treatment by a homeopathic practitioner

               -  Initiation of another treatment for Long Covid within the past 2 months