PK/PD and Long Term Safety Study of Benralizumab in Children With Severe Eosinophilic Asthma
Condition: Severe Uncontrolled Asthma
MeSH terms: Asthma; Pulmonary Eosinophilia
Intervention: Benralizumab
Intervention description: Dose will be stratified by body weight at screening: Patients will receive Dose 1 or Dose 2 of Benralizumab administered by SC injection at Day 0 and Weeks 4, 8, and 16, 24, 32, and 40.
Intervention MeSH terms: Benralizumab
Phase: Phase 3
Study type: Interventional
Primary purpose: Basic Science
Allocation: Non-Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 30.0
Sex: All
Minimum age: 6 Years
Maximum age: 14 Years
Healthy volunteers: No
Keywords: Pediatric; PK; severe asthma

Summary:

      This study will evaluate the PK, PD and long-term safety of Benralizumab administered
      subcutaneously in 30 children aged 6 to 11 years with severe eosinophilic asthma. Up to an
      additional 3 Japanese patients aged 12 to 14 years will be enrolled to meet local regulatory
      requirements.
    

Eligibility criteria:

        Inclusion Criteria:

        Patients are eligible to be included in the study only if all of the following inclusion
        criteria and none of the exclusion criteria apply:

          1. Parent(s)/guardian are able to give written informed consent prior to participation in
             the study, which will include the ability to comply with the requirements and
             restrictions listed in the consent form. If applicable, the participant must be able
             and willing to give assent to take part in the study according to the local
             requirement.

          2. Patient must be 6 to 11 years of age inclusive (6 to 14 years of age inclusive in
             Japan), at the time of signing the ICF.

          3. Diagnosis of severe asthma, defined by the regional guidelines for at least 12 months
             prior to Visit 1.

          4. A previously confirmed history of two or more exacerbations requiring treatment with
             systemic corticosteroids and/or hospitalization in the 12 months prior to Visit 1.

          5. Peripheral blood eosinophil count of ≥ 150 cells / µL at Visit 1.

          6. A well-documented requirement for regular treatment with ICS: eg. total daily dose
             equivalent to ≥ 250 µg fluticasone propionate, in the 12 months prior to Visit 1, with
             or without maintenance oral corticosteroids.

          7. Current treatment with at least 1 additional controller medication, such as inhaled
             LABA, leukotriene receptor antagonist, long acting anti-muscarinic agent, or
             theophylline, since at least 3 months prior to Visit 1.

          8. Pre-bronchodilator FEV1 ≤ 110% predicted normal, or, FEV1/Forced Vital Capacity (FVC)
             ratio ≤ 0.8.

          9. Body weight ≥15 kg.

         10. Male or female

         11. Females of childbearing potential (FOCBP) who are sexually active, as judged by the
             investigator, must commit to consistent and correct use of an acceptable method of
             contraception for the duration of the study and for 4 months after the last dose of
             IP.

        Exclusion Criteria:

        Patients are eligible to be included in the study only if all of the inclusion criteria and
        none of the exclusion criteria apply:

          1. Any history of life-threatening asthma (eg, requiring intubation).

          2. Clinically important pulmonary disease other than asthma such as active lung
             infection, bronchiectasis, pulmonary fibrosis, cystic fibrosis, alpha 1 anti-trypsin
             deficiency, and primary ciliary dyskinesia.

          3. Previous diagnosis of pulmonary or systematic disease, other than asthma, that is
             associated with elevated peripheral eosinophil counts such as allergic
             bronchopulmonary aspergillosis/mycosis, eosinophilic granulomatosis with polyangiitis
             (Churg-Strauss syndrome), and hypereosinophilic syndrome.

          4. Ever been diagnosed with malignant disease.

          5. Any disorder, including, but not limited to, cardiovascular, gastrointestinal,
             hepatic, renal, neurological, musculoskeletal, immunological, psychiatric, or major
             physical impairment that is not stable in the opinion of the investigator and could:

               1. Affect the safety of the patient throughout the study.

               2. Influence the findings of the study or their interpretations.

               3. Impede the patient's ability to complete the entire duration of the study.

          6. History of anaphylaxis to any biologic therapy.

          7. Any clinically significant abnormal findings in physical examination, vital signs,
             haematology, clinical chemistry, or urinalysis during screening period, which in the
             opinion of the investigator may put the patient at risk because of his/her
             participation in the study, or may influence the results of the study, or the
             patient's ability to complete the entire duration of the study.

          8. Any clinically significant cardiac disease or any electrocardiogram (ECG) abnormality
             obtained during the screening period, which in the opinion of the investigator may put
             the patient at risk or interfere with study assessments.

          9. Positive hepatitis B surface antigen, or hepatitis C virus antibody serology, or a
             positive medical history for hepatitis B or C. Patients with a history of hepatitis B
             vaccination without history of hepatitis B are allowed to enrol.

         10. A helminth parasitic infection diagnosed within 24 weeks prior to the date of informed
             consent and assent is obtained that has not been treated with, or has failed to
             respond to, standard of care therapy.

         11. Alanine aminotransferase or aspartate aminotransferase level ≥ 1.5 times the upper
             limit of normal confirmed during the screening period.

         12. A history of known immunodeficiency disorder including a positive human
             immunodeficiency virus (HIV) test.

         13. Use of immunosuppressive medication, including, but not limited to, methotrexate,
             troleandomycin, cyclosporine, azathioprine, intramuscular long-acting depot
             corticosteroid, or any experimental anti-inflammatory therapy, within 3 months prior
             to Visit 1. Chronic maintenance corticosteroid for the treatment of asthma is allowed.

         14. Receipt of immunoglobulin or blood products within 30 days prior to Visit 1.

         15. Receipt of any marketed (eg, Omalizumab, Mepolizumab, or off-label Benralizumab) or
             investigational biologic within 4 months or 5 half-lives, whichever is longer, prior
             to Visit 1.

         16. Receipt of live attenuated vaccines 30 days prior to the date of first dose of IP.

         17. Initiation of new allergen immunotherapy is not allowed within 30 days prior to Visit
             1. However, allergen immunotherapy initiated prior to this period can be continued
             provided there is a gap of 7 days between the immunotherapy and IP administration.

         18. Current use of any oral or ophthalmic non-selective β-adrenergic antagonist (eg,
             propranolol).

         19. Planned surgical procedures during the conduct of the study.

         20. Participation in another clinical study with an investigational nonbiologic product
             administered in the last 30 days or 5 half-lives prior to enrolment, whichever is
             longer.

         21. Known history of allergy or reaction to any component of the IP formulation.

         22. Concurrent enrolment in another clinical study.

         23. Parent/guardian has a history of psychiatric disease, intellectual deficiency,
             substance abuse, or other condition (eg, inability to read, comprehend and write)
             which will limit the validity of consent to participate in this study.

         24. Unwillingness or inability of the participant or parent/guardian to follow the
             procedures outlined in the protocol.

         25. Children who are wards of the state or government.

         26. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca
             staff and/or staff at the study site).

         27. Judgement by the investigator that the patient should not participate in the study if
             the patient is unlikely to comply with study procedures, restrictions and
             requirements.

         28. Previous treatment in the present study.