A Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib
Condition: Primary Myelofibrosis; Post-Polycythemia Vera Myelofibrosis; Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis
MeSH terms: Polycythemia Vera; Primary Myelofibrosis; Polycythemia; Thrombocytosis; Thrombocythemia, Essential
Intervention: FEDRATINIB
Intervention description: A potent and selective inhibitor of JAK2 kinase activity
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 38.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Myelofibrosis (MF); Primary Myelofibrosis (PMF); Post-Polycythemia Vera Myelofibrosis (Post-PV); Post-essential thrombocythemia Myelofibrosis (Post-ET); Myeloproliferative neoplasms (MPN)

Summary:

      This is Single-Arm, Open-Label Efficacy and Safety Trial of Fedratinib in Subjects with DIPSS
      (Dynamic International Prognostic Scoring System)-Intermediate or High- Risk Primary
      Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (post-PV MF), or Post-Essential
      Thrombocythemia Myelofibrosis (post-ET MF) and Previously Treated with Ruxolitinib.

      The primary objective of the study is to evaluate the percentage of subjects with at least a
      35% reduction in spleen size and one of the secondary objectives is to evaluate the safety of
      fedratinib.
    

Eligibility criteria:

        Inclusion Criteria:

        Main Study Inclusion Criteria

          1. Subject is at least 18 years of age at the time of signing the informed consent form
             (ICF)

          2. Subject has an Eastern Cooperative Oncology Group (ECOG) Performance Score (PS) of 0,
             1 or 2

          3. Subject has diagnosis of primary myelofibrosis (PMF) according to the 2016 World
             Health Organization (WHO) criteria, or diagnosis of post-ET or post-PV myelofibrosis
             according to the IWG-MRT 2007 criteria, confirmed by the most recent local pathology
             report

          4. Subject has a DIPSS Risk score of Intermediate or High

          5. Subject has a measurable splenomegaly during the screening period as demonstrated by
             spleen volume of ≥ 450 cm3 by MRI or CT-scan assessment or by palpable spleen
             measuring ≥ 5 cm below the left costal margin.

          6. Subject has been previously exposed to ruxolitinib, while diagnosed with MF (PMF,
             post-ET MF or post-PV MF), and must meet at least one of the following criteria (a or
             b)

               1. Treatment with ruxolitinib for ≥ 3 months

               2. Treatment with ruxolitinib for ≥ 28 days complicated by any of the following:

                    -  Development of a red blood cell transfusion requirement (at least 2
                       units/month for 2 months) or

                    -  Grade ≥ 3 AEs of thrombocytopenia, anemia, hematoma, and/or hemorrhage while
                       on treatment with ruxolitinib

          7. Subject must have treatment-related toxicities from prior therapy resolved to Grade 1
             or pretreatment baseline before start of last therapy prior to fedratinib treatment.

          8. Subject must understand and voluntarily sign an ICF prior to any study-related
             assessments/procedures being conducted

          9. Subject is willing and able to adhere to the study visit schedule and other protocol
             requirements

         10. Participants must agree to use effective contraception

        Exclusion Criteria:

        Main Study Exclusion Criteria

          1. Any of the following laboratory abnormalities:

               1. Platelets < 50,000/μL

               2. Absolute neutrophil count (ANC) < 1.0 x 109/L

               3. White blood count (WBC) > 100 x 10^9/L

               4. Myeloblasts > 5 % in peripheral blood

               5. Estimated glomerular filtration rate < 30 mL/min/1.73 m^2 (as per the
                  Modification of Diet in Renal Disease [MDRD] formula)

               6. Serum amylase or lipase > 1.5 x ULN (upper limit of normal)

               7. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x ULN

               8. Total bilirubin > 1.5 x ULN, subject's total bilirubin between 1.5 - 3.0 x ULN
                  are eligible if the direct bilirubin fraction is < 25% of the total bilirubin

          2. Subject is pregnant or lactating female

          3. Subject with previous splenectomy

          4. Subject with previous or planned hematopoietic cell transplant

          5. Subject with prior history of encephalopathy, including Wernicke's

          6. Subject with signs or symptoms of encephalopathy including Wernicke's (eg, severe
             ataxia, ocular paralysis or cerebellar signs)

          7. Subject with thiamine deficiency, defined as thiamine levels in whole blood below
             normal range according to institutional standard and not corrected prior to enrollment
             on the study

          8. Subject with concomitant treatment with or use of pharmaceutical, herbal agents or
             food known to be strong or moderate inducers of Cytochrome P450 3A4 (CYP3A4), or dual
             CYP2C19 and CYP3A4 inhibitors

          9. Subject on any chemotherapy, immunomodulatory drug therapy (eg, thalidomide,
             interferon-alpha), anagrelide, immunosuppressive therapy, systemic corticosteroids >
             10 mg/day prednisone or equivalent. Subjects who have had prior exposure to
             hydroxyurea (eg, Hydrea) in the past may be enrolled into the study as long as it has
             not been administered within 14 days prior to the start of fedratinib treatment

         10. Subject has received ruxolitinib within 14 days prior to the start of fedratinib

         11. Subject on treatment with myeloid growth factor (eg, granulocyte-colony stimulating
             factor [G-CSF]) within 14 days prior to the start of fedratinib treatment

         12. Subject with previous exposure to Janus kinase (JAK) inhibitor(s) for more than 1
             cycle other than ruxolitinib treatment

         13. Subject on treatment with aspirin with doses > 150 mg daily

         14. Subject with major surgery within 28 days before starting fedratinib treatment

         15. Subject with diagnosis of chronic liver disease (eg, chronic alcoholic liver disease,
             autoimmune hepatitis, sclerosing cholangitis, primary biliary cirrhosis,
             hemochromatosis, non-alcoholic steatohepatitis)

         16. Subject with prior malignancy other than the disease under study unless the subject
             has not required treatment for the malignancy for at least 3 years prior to
             enrollment.

             However, subject with the following history/concurrent conditions provided
             successfully treated may enroll: non-invasive skin cancer, in situ cervical cancer,
             carcinoma in situ of the breast, incidental histologic finding of prostate cancer (T1a
             or T1b using the tumor, nodes, metastasis [TNM] clinical staging system), or is free
             of disease and on hormonal treatment only

         17. Subject with uncontrolled congestive heart failure (New York Heart Association
             Classification 3 or 4)

         18. Subject with known human immunodeficiency virus (HIV), known active infectious
             Hepatitis B (HepB), and/or known active infectious Hepatitis C (HepC)

         19. Subject with serious active infection

         20. Subject with presence of any significant gastric or other disorder that would inhibit
             absorption of oral medication

         21. Subject is unable to swallow capsule

         22. Subject has any significant medical condition, laboratory abnormality, or psychiatric
             illness that would prevent the subject from participating in the study

         23. Subject has any condition including the presence of laboratory abnormalities, which
             places the subject at unacceptable risk if he/she were to participate in the study

         24. Subject has any condition that confounds the ability to interpret data from the study

         25. Subject with participation in any study of an investigational agent (drug, biologic,
             device) within 30 days prior to start of fedratinib treatment

         26. Subject with life expectancy of less than 6 months.