Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone as 2nd-Line Treatment in PAC
Condition: Pancreatic Adenocarcinoma
MeSH terms: Adenocarcinoma
Intervention: eryaspase; Gemcitabine plus Abraxane; Irinotecan plus 5-FU plus leucovorin
Intervention description: L-asparaginase encapsulated in erythrocytes (red blood cells); gemcitabine, Abraxane; irinotecan, 5-FU, leucovorin
Intervention MeSH terms: Leucovorin; Paclitaxel; Gemcitabine; Irinotecan; Albumin-Bound Paclitaxel; Asparaginase; Eryaspase
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 512.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: pancreatic; cancer; asparaginase; gemcitabine; Abraxane; asparagine depletion; onivyde; nab-paclitaxel; folinic acid; fluorouracil; irinotecan; leucovorin; amino acid; RECIST 1.1

Summary:

      This is an open-label, multicenter, randomized, Phase 3 study in patients with ductal
      adenocarcinoma of the pancreas who have failed only one prior line of systemic anti-cancer
      therapy for advanced pancreatic cancer and have measurable disease.
    

Eligibility criteria:

        Inclusion Criteria:

        A patient will be eligible for the study if all the following criteria are met:

          1. Must be 18 years of age or older.

          2. Must have histologically confirmed pancreatic adenocarcinoma.

          3. Must have Stage III or IV disease.

          4. Must have received one line of systemic chemotherapy in the advanced setting with or
             without targeted agents, immunotherapy, or radiotherapy for treatment of advanced
             pancreatic adenocarcinoma.

          5. Must have radiological evidence of disease progression following most recent prior
             treatment, defined as appearance of any new lesion or increase of >20% of one or more
             existing lesions.

          6. Must have measurable lesion(s) per RECIST version 1.1 by CT scan with contrast (or
             MRI, if the patient is allergic to CT contrast media).

             NOTE: Bone disease consisting of blastic lesion only is not measurable.

          7. Archival or fresh tumor tissue must be available for evaluating relevant biomarkers.
             Formalin-fixed paraffin-embedded [FFPE] block preferred, or a minimum of 10 unstained
             FFPE slides of one archived block is required.

             NOTE: Cytology samples from fine needle aspirates or brushing biopsies are not
             sufficient.

             If archival tissue is unavailable and an elective biopsy can't be scheduled due to
             COVID, this will be waived.

          8. Must have adequate performance status:

               1. ECOG Performance Status (PS) score of 0, or

               2. ECOG PS score one and score ≥80 on Karnofsky Performance Status (KPS) scale.
                  NOTE: Must have body mass index (BMI) ≥18.5 kg/m2 (obtained <14 days prior to
                  randomization.

          9. Must have life expectancy of >12 weeks according to the investigator's clinical
             judgment.

         10. Females of childbearing potential must have a negative pregnancy test at screening and
             additional negative pregnancy test prior to first dose. Males and females of
             childbearing potential must agree to use a highly effective method of contraception
             during treatment and for at least 6 months after the last dose of study treatment.

         11. Must have adequate laboratory parameters at baseline (obtained <14 days prior to
             randomization). Laboratory parameters outside of these ranges that are deemed
             clinically insignificant should be discussed with the medical monitor:

               1. Absolute neutrophil count ≥1.5 x 109/L.

               2. Hemoglobin ≥9 g/dL. Patients with a baseline Hemoglobin ≥13 g/dL should be
                  discussed with the medical monitor.

               3. Platelet count ≥100,000/mm3 (100 x 109/L).

               4. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 x upper
                  limit of normal (ULN) (≤5 x ULN in presence of liver metastases).

               5. Total bilirubin ≤ 1.5 x institutional ULN.

               6. Serum creatinine within normal limits or calculated clearance >60 mL/min/1.73 m2
                  for patients with serum creatinine levels above or below the institutional normal
                  range.

               7. Acceptable coagulation parameters: plasma antithrombin III >70% and fibrinogen
                  ≥1.5 g/L

               8. Serum albumin ≥3.0 g/dL.

         12. Patients requiring biliary stent placement must have the biliary stent placed >7 days
             prior to screening and must have normalization of bilirubin level after stenting.

         13. Must not be receiving therapy in a concurrent clinical study and must agree not to
             participate in any other interventional clinical studies during their participation in
             this trial while on study treatment. Patients taking part in surveys or observational
             studies are eligible to participate in this study.

         14. Must be able to understand and comply with the conditions of the protocol and must
             have read and understood the consent form and provided written informed consent.

        Exclusion Criteria:

        A patient is not eligible to participate in the study if any of the following criteria are
        met:

          1. Resectable or borderline resectable pancreatic adenocarcinoma at the time of signing
             the informed consent.

          2. Histology other than pancreatic adenocarcinoma (for example, but not inclusive:
             neuroendocrine, adenosquamous, etc.).

          3. More than one line of prior treatment in advanced or metastatic setting.

          4. Patient has experienced medically significant acute decline in clinical status
             including

               1. Decline in ECOG PS to >1 (or KPS <70) between baseline visit and within 72 hours
                  prior to randomization.

               2. Weight loss of ≥10% during screening.

          5. Presence of active or symptomatic untreated central nervous system (CNS) metastases.

             NOTE: Patients with asymptomatic or stable CNS metastases are eligible, provided that
             the CNS metastases are radiologically and clinically stable, and the patient is off
             high-dose steroid treatment for at least one month prior to randomization.

          6. Prior radiotherapy to the only area of measurable disease. NOTE: Patients must have
             completed treatment and recovered from all acute treatment-related toxicities prior to
             administration of the first dose of eryaspase or chemotherapy.

          7. Bone as the only site of metastatic disease from pancreatic cancer (bone only
             disease).

          8. History of recent clinical pancreatitis, according to revised Atlanta criteria, within
             3 months of randomization.

             NOTE: The revised Atlanta classification [1] requires that two or more of the
             following criteria be met for the diagnosis of acute pancreatitis: (a) abdominal pain
             suggestive of pancreatitis, (b) serum amylase or lipase level ≥3 x ULN, or (c)
             characteristic imaging findings using CT or MRI.

          9. Neurosensory neuropathy > Grade 2 at baseline.

         10. Pregnancy or breastfeeding.

         11. History of infection with human immunodeficiency virus (HIV) and/or active infection
             with hepatitis B or hepatitis C.

             NOTE: Patients with unknown status of hepatitis B or C must be tested and declared
             negative before randomization.

         12. Hypersensitivity to any of the components of the chemotherapy or ASNase.

         13. Patients who have received live or live attenuated vaccines within 3 weeks of
             randomization.

         14. History of other malignancies NOTE: Adequately treated non-melanoma skin cancer or
             curatively treated in-situ cancer of the cervix may be eligible.

             NOTE: Patients successfully treated for other malignancies and are disease-free for at
             least 5 years may be eligible.

         15. Any other severe acute or chronic condition/treatments that may increase the risk of
             study participation including:

               1. History of abdominal fistula, gastrointestinal perforation, peptic ulcer, or
                  intra-abdominal abscess within 6 months prior to randomization.

               2. Current or history within 6 months prior to randomization of medically
                  significant cardiovascular disease including symptomatic congestive heart failure
                  >New York Heart Association (NYHA) Class II, unstable angina pectoris, clinically
                  significant cardiac arrhythmia.

               3. Patients with pre-existing coagulopathy (e.g. hemophilia).

               4. Psychiatric illness/social situations or any other serious uncontrolled medical
                  disorders in the opinion of the Investigator that would limit compliance with
                  study requirements.