The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects
Condition: Weight Loss; Obesity
MeSH terms: Body Weight; Weight Loss
Intervention: Byetta (exenatide); Weight loss; Metabolic Chamber; Placebo
Intervention description: Exenatide is an injectable medication; Because response to weight loss; The subject stays in the small room
Intervention MeSH terms: Exenatide
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Enrollment: 150.0
Sex: All
Minimum age: 18 Years
Maximum age: 55 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Weight Loss; Byetta (Exenatide); Energy Expenditure; Food Intake; Obesity

Summary:

      Exenatide is an incretin-like drug that has been approved for treatment of type 2 diabetes;
      it improves glycemia by increasing insulin and decreasing glucagon secretion by pancreatic
      islet cells and delaying gastric emptying. This randomized, placebo-controlled study is to
      evaluate whether exenatide over a 5 week period in non-diabetic obese subjects may lead to
      weight loss. To control for variability in individual response to weight loss treatment, this
      study will assess the role of exenatide in changing food intake and energy expenditure as
      possible sources of weight loss. This study will also evaluate the safety profile of
      exenatide in non-diabetic obese people. Additional assessments will evaluate changes in body
      fat and hormones involved in the sensations of hunger and fullness.
    

Eligibility criteria:

        -  INCLUSION CRITERIA:

          -  Premenopausal women and men < 55 years of age

          -  BMI >30 kg/m(2)

          -  Expressed desire for weight loss

          -  Stable weight (variation < 2.3 kg within past 6 months)

          -  Ability to provide informed consent

          -  Ability to follow verbal and written instructions

          -  Nonsmoker

          -  Ability to commute to study site on a regular basis for short outpatient visits over 5
             weeks

          -  For females, use of a medically approved form of contraception. For oral
             contraceptives, subjects will need to be on an established dose for at least 3 months
             to ensure stable weight and will be asked not to switch contraceptive methods during
             study participation.

        EXCLUSION CRITERIA:

          -  Age < 18 years

          -  Use of other medications to treat obesity including medications obtained over the
             counter or internet, orlistat (Xenical, Alli), sibutramine (Meridia), topiramate (with
             or without phentermine (Qsymia), phentermine (Adipex P) or lorcaserin (Belviq) within
             the past 6 months

          -  History of an eating disorder including anorexia or bulimia

          -  History of surgery for the treatment of obesity (gastric banding, gastric bypass)

          -  Diagnosis of type 1 or type 2 diabetes mellitus according to American Diabetes
             Association guidelines

          -  Previous exposure to exenatide

          -  Uncontrolled hypertension as defined by a blood pressure of 150/90 on two or more
             occasions or use of antihypertensive medications which may affect energy expenditure
             including alpha blockers, beta blockers, angiotensin receptor blockers or inhibitors
             of angiotensin converting enzyme

          -  Current use of tobacco products, marijuana, amphetamines, cocaine or intravenous drug
             use

          -  Chronic ethanol use (> 3 drinks /day)

          -  Endocrine disorders including hypo or hyperthyroidism (including subclinical disease),
             Cushing s disease, growth hormone deficiency or other pituitary diseases

          -  History of pancreatitis

          -  Personal or family history of multiple endocrine neoplasia (MEN)-2 or medullary
             thyroid cancer

          -  History of unresolved gallstones

          -  Hyperamylasemia

          -  Fasting triglyceride level greater than or equal to 500

          -  Gastroparesis

          -  Inflammatory bowel disease or malabsorption disorders

          -  Malignancy treated with chemotherapy or radiation within the past 5 years

          -  Current clinical depression, diagnosis of psychosis or recent use of psychotropic
             medication

          -  Pregnancy within past 6 months

          -  Breastfeeding

          -  Failure to use medically approved contraceptive methods if subject is female

          -  Liver function abnormalities (transaminases greater than twice normal)

          -  Renal insufficiency (creatinine clearance < 50 ml/min)

          -  History of chronic infection including tuberculosis, coccidiomycoses, lyme disease or
             HIV infection

          -  Pulmonary disorders, including chronic obstructive pulmonary disease, which would
             limit ability to follow the protocol (investigator judgment)

          -  Cardiovascular disease including history of myocardial infarction, unstable angina or
             heart failure

          -  Central nervous system disease, including history of cerebrovascular accidents,
             dementia, and neurodegenerative disorders

          -  Weight <450 pounds (maximum weight of the DXA machine as per manufacturer s manual)

          -  Sensitivity to exenatide or any inert components in its formulation

          -  Sensitivity to acetaminophen

          -  Conditions not specifically mentioned above may serve as criteria for exclusion at the
             discretion of the investigators