A Study to Evaluate the Efficacy and Safety of Dasotraline in Children 6 to 12 Years of Age With Attention-Deficit Hyperactivity Disorder (ADHD) in a Simulated Classroom Setting.
Condition: Attention-Deficit Hyperactivity Disorder (ADHD)
MeSH terms: Hyperkinesis; Attention Deficit Disorder with Hyperactivity
Intervention: dasotraline 4mg; Placebo
Intervention description: dasotraline 4mg/day; placebo/day
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Double (Participant, Investigator)
Enrollment: 132.0
Sex: All
Minimum age: 6 Years
Maximum age: 12 Years
Healthy volunteers: No
Keywords: Attention-Deficit Hyperactivity Disorder (ADHD)

Summary:

      A study to evaluate the efficacy and safety of dasotraline in children 6 years of age to 12
      years of age with Attention-Deficit Hyperactivity Disorder (ADHD) in a simulated classroom
      setting.
    

Eligibility criteria:

        Inclusion Criteria:

          -  1. Subject is 6 - 12 years old, inclusive at screening and randomization. 2. At least
             one of the subject's parents/legal guardians must give written informed consent,
             including privacy authorization, prior to study participation. The subject will
             provide informed assent prior to study participation.

             3. Subject meets Diagnostic and Statistical Manual of Mental Disorders Fifth Edition
             (DSM-5) criteria for a primary diagnosis of ADHD (inattentive, hyperactive, or
             combined presentation) at screening established by a comprehensive psychiatric
             evaluation that reviews DSM-5 criteria and confirmed using the Schedule for Affective
             Disorders and Schizophrenia for School-Age Children-Present and Lifetime version
             (K-SADS-PL) at screening.

             4. Subject is currently on a treatment regimen of a methylphenidate formulation within
             the approved labeled dose range for ADHD for at least 6 weeks prior to Day -7 with the
             same dose level for at least 1 week immediately prior to Day -7. Note: if any doses of
             methylphenidate were missed during the week prior to Day-7, the subject's eligibility
             will be discussed with the Medical Monitor.

             5. In the opinion of the investigator, methylphenidate well tolerated and clinically
             effective based on clinical assessment and informant interview, as well as, review of
             available medical records. Note: The ADHD Rating Scale Version IV - Home Version
             (modified for investigator administration) (ADHD-RS-IV HV) will be administered at
             Screening by the investigator to inform clinical evaluation.

             6. Subject is male or a non-pregnant, non-lactating female. 7. Subject, if female,
             must not be pregnant or breastfeeding, and if ≥ 8 years of age must have a negative
             serum pregnancy test at screening.

             8. Female subjects of childbearing potential and male subjects with female partners of
             childbearing potential must practice true abstinence (consistent with lifestyle) and
             must agree to remain abstinent or agree to use an effective and medically acceptable
             form of birth control, from the time of informed consent/assent to at least 14 days
             after the last dose of the study drug has been taken.

             9. Subject must be in general good health (defined as the absence of any clinically
             relevant abnormalities as determined by the investigator) based on screening physical
             and neurological examinations, medical history, and clinical laboratory values
             (hematology, chemistry, and urinalysis). Note: If any of the hematology, chemistry, or
             urinalysis results are not within the laboratory's reference range, then the subject
             can be included only if the investigator determines the deviations to be not
             clinically relevant.

             10. Subject is within the 3rd to 97th percentile for gender specific body mass index
             (BMI)-for-age from the World Health Organization (WHO) growth charts and weighs at
             least 21 kg.

             11. Subject must report a history of being able to swallow capsules. 12. Subject and
             subject's parent/legal guardian must be able to fully comprehend the informed
             consent/assent forms, understand and be willing and able to comply with all study
             procedures and visit schedule, and be able to communicate satisfactorily with the
             investigator and study coordinator.

        Exclusion Criteria:

          -  1. Subject or parent/legal guardian has commitments during the study that would
             interfere with attending study visits.

             2. Subject, on Day 1, has not demonstrated evidence of worsening of ADHD symptoms as
             measured by ADHD-RS-IV HV total score ≥ 26 and at least a 30% worsening in ADHD-RS-IV
             HV total score since the last assessment and following a minimum 72-hour washout from
             prior methylphenidate treatment.

             3. Subject is currently being treated for ADHD with an amphetamine-based product, or
             has been treated with an amphetamine-based product in the 6 weeks prior to the start
             of screening.

             4. Subject is currently being treated for ADHD with a non-methylphenidate product, or
             has been treated with a non-methylphenidate product in the 6 weeks prior to the start
             of screening.

             5. Subject has failed 2 adequate courses (dose and duration) of stimulant or
             non-stimulant treatment for ADHD, as judged by the investigator.

             6. Subject currently has a diagnosis of asthma that has required daily treatment with
             bronchodilators or nebulizer treatments in the 30 days prior to screening and/or who
             may require daily treatments with these agents over the course of the trial.
             Intermittent use of bronchodilators is not exclusionary. Subjects who have a history
             of requiring persistent asthma treatment should be discussed with the medical monitor
             prior to randomization.

             7. Subject has any clinically significant unstable medical abnormality, chronic
             disease, or a history of a clinically significant abnormality of the cardiovascular,
             gastrointestinal, respiratory, hepatic, or renal systems, or a disorder or history of
             a condition (eg, malabsorption, gastrointestinal surgery) that may interfere with drug
             absorption, distribution, metabolism, or excretion. Note: Active medical conditions
             that are minor or well-controlled are not exclusionary if they do not affect risk to
             the subject or the study results. In cases in which the impact of the condition upon
             risk to the subject or study results is unclear, the medical monitor should be
             consulted. Any subject with a known cardiovascular disease or condition (even if
             controlled) must be discussed with the medical monitor during screening.

             8. Subject has a history or presence of abnormal ECGs, which in the investigator's
             opinion is clinically significant. Screening site ECGs will be centrally over-read,
             and eligibility will be determined by the investigator based on the results of the
             over-read report.

             9. Subject has any diagnosis of bipolar I or II disorder, major depressive disorder,
             conduct disorder, obsessive-compulsive disorder, any history of psychosis, autism
             spectrum disorder, disruptive mood dysregulation disorder (DMDD), intellectual
             disability, Tourette's Syndrome, confirmed genetic disorder with cognitive and/or
             behavioral disturbances. Note: Subjects with oppositional defiant disorder (ODD) are
             permitted to enroll in the study as long as ODD is not the primary focus of treatment.

             10. Subject has generalized anxiety disorder or panic disorder that has been the
             primary focus of treatment at any time during the 12 months prior to screening or that
             has required pharmacotherapy any time during the 6 months prior to screening.

             11. Subject has evidence of any chronic disease of the central nervous system (CNS)
             such as tumors, inflammation, seizure disorder, vascular disorder, potential CNS
             related disorders that might occur in childhood (eg, Duchenne Muscular dystrophy,
             myasthenia gravis, or other neurologic or serious neuromuscular disorders), or history
             of persistent neurological symptoms attributable to serious head injury. Past history
             of febrile seizure, drug-induced seizure, or alcohol withdrawal seizure is
             exclusionary. Subject taking anticonvulsants for seizure control currently or within
             the past 2 years is not eligible for study participation.

             12. Subject has uncontrolled thyroid disorder as evidenced by thyroid stimulating
             hormone (TSH) ≤ 0.8 x the lower limit of normal (LLN) or ≥ 1.25 x the upper limit of
             normal (ULN) for the reference laboratory.

             13. Subject answers "yes" to "Suicidal Ideation" item 4 (active suicidal ideation with
             some intent to act, without specific plan) or item 5 (active suicidal ideation with
             specific plan and intent) for any lifetime history on the C-SSRS Children's
             Lifetime/Recent assessment at screening.

             14. Subject has any history of attempted suicide or clinically significant suicidal
             ideation, in the opinion of the investigator.

             15. Subject has a history of severe allergies to more than 1 class of medication or
             multiple adverse drug reactions or has a history of allergic reaction or has a known
             or suspected sensitivity to any substance that is contained in the study drug
             formulations.

             16. Subject has history of intolerance (safety) or lack of efficacy to stimulants.

             17. Subject has taken any antipsychotic medication within 6 months prior to screening.

             18. Subject has taken any herbal and/or complementary treatments, eg, St. John's Wort,
             within 7 days prior to Day 1.

             19. Subject has taken any antidepressant medication (eg, bupropion, selective
             serotonin reuptake inhibitor [SSRI]/ serotonin norepinephrine reuptake inhibitor
             [SNRI], tricyclic, etc) within 7 days prior to Day 1.

             20. Subject has taken any monoamine oxidase [MAO] inhibitor within 21 days prior to
             Day 1.

             21. Subject is currently undergoing Cognitive Behavioral Therapy (CBT) for the
             treatment of ADHD, has initiated behavioral therapy (including school based
             interventions) less than 1 month prior to screening, or is receiving behavioral
             therapy and in the opinion of the investigator will not be able to follow a stable
             routine for the duration of the study. Note: Unavoidable changes in school-based
             interventions that occur during study participation will not be exclusionary, but
             should be documented by the investigator, to the extent possible.

             22. Subject or subject's family anticipates a move outside the geographic range of
             investigative site during the study period, or plans extended travel inconsistent with
             the recommended visit interval during study duration.

             23. Subject has history of, or current malignancy except for non-melanomatous skin
             cancer.

             24. Subject has history of positive test for Hepatitis B surface antigen or Hepatitis
             C antibody.

             25. Subject is known to have tested positive for human immunodeficiency virus (HIV).

             26. Subject has participated in a classroom study within 6 months prior to the start
             of screening or has participated in any other clinical study with an investigational
             drug/product within 90 days prior to the start of screening or is currently
             participating in another clinical trial.

             27. Subject shows evidence of substance or alcohol use or is currently using tobacco
             or other nicotine-containing products, or has a positive urine drug screen (UDS) at
             screening. Note: Subjects with a positive UDS may be allowed to continue in the study,
             provided that the investigator determines that the positive test is as a result of
             taking medications as prescribed after consultation with the medical monitor.

             28. Subject is taking any disallowed medications for chronic treatment. 29. Subject
             has previously been enrolled in a clinical trial of dasotraline (SEP-225289).

             30. Subject's parent/legal guardian is an investigational site staff member or the
             relative of an investigational site staff member.

             31. Subject is, in the opinion of the investigator, unsuitable in any other way to
             participate in this study.

             32. Subject's sibling or family member living in the same household is participating
             in the same laboratory classroom cohort for this study.

             33. Subject is unable to perform at the basic level of the standardized math test as
             defined in the laboratory classroom manual.