A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer
Condition: Colorectal Cancer
MeSH terms: Colorectal Neoplasms
Intervention: Napabucasin; Fluorouracil; Leucovorin; Irinotecan; Bevacizumab
Intervention description: Napabucasin 240 mg will be administered orally, twice daily, with doses separated by approximately 12 hours (480 mg total daily dose).
Intervention MeSH terms: Leucovorin; Bevacizumab; Fluorouracil; Irinotecan
Phase: Phase 3
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 1253.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Colorectal Neoplasms; Colonic Diseases; Digestive System Diseases; Digestive System Neoplasms; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Intestinal Diseases; Intestinal Neoplasms; Neoplasms; Neoplasms by Histologic Type; Neoplasms by Site; Neoplasms, Glandular and Epithelial; Rectal Diseases

Summary:

      This is an international multi-center, prospective, open-label, randomized, adaptive design
      phase 3 trial of the cancer stem cell pathway inhibitor napabucasin plus standard bi-weekly
      FOLFIRI versus standard bi-weekly FOLFIRI in patients with previously treated metastatic
      colorectal cancer (CRC).
    

Eligibility criteria:

        Inclusion Criteria:

          1. Written, signed consent for trial participation must be obtained from the patient
             appropriately in accordance with applicable ICH guidelines and local and regulatory
             requirements prior to the performance of any study specific procedure.

          2. Must have histologically confirmed advanced CRC that is metastatic.

          3. Must have failed treatment with one regimen containing a fluoropyrimidine, oxaliplatin
             with or without bevacizumab for metastatic disease. All patients must have received a
             minimum of 6 weeks of the first-line regimen that included bevacizumab (if
             applicable), oxaliplatin and a fluoropyrimidine in the same cycle. Treatment failure
             is defined as radiologic progression during or < 6 months after the last dose of
             first-line therapy.

          4. FOLFIRI therapy is appropriate for the patient and is recommended by the Investigator.

          5. Imaging investigations including CT/MRI of chest/abdomen/pelvis or other scans as
             necessary to document all sites of disease performed within 21 days prior to
             randomization. Patients with either measurable disease or non-measurable evaluable
             disease are eligible.

          6. Must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.

          7. Must be ≥ 18 years of age.

          8. For male or female patient of child bearing potential: Must agree to use contraception
             or take measures to avoid pregnancy during the study and for 180 days for female and
             male patients, of the final FOLFIRI dose. Patients who receive single agent
             napabucasin without FOLFIRI must agree to use contraception or take measures to avoid
             pregnancy during the study and for 30 days for female patients and 90 days for male
             patients, of the final napabucasin dose.

          9. Women of child bearing potential (WOCBP) must have a negative serum or urine pregnancy
             test within 5 days prior to randomization. The minimum sensitivity of the pregnancy
             test must be 25 IU/L or equivalent units of HCG.

         10. Must have alanine transaminase (ALT) ≤ 3 × institutional upper limit of normal (ULN)
             [≤ 5 × ULN in presence of liver metastases] within 14 days prior to randomization.

         11. Must have hemoglobin (Hgb) ≥ 9.0 g/dL within 14 days prior to randomization. Must not
             have required transfusion of red blood cells within 1 week of baseline Hgb assessment.

         12. Must have total bilirubin ≤ 1.5 × institutional ULN [≤ 2.0 x ULN in presence of liver
             metastases] within 14 days prior to randomization.

         13. Must have creatinine ≤ 1.5 × institutional ULN or Creatinine Clearance > 50 ml/min (as
             calculated by the Cockcroft-Gault equation (Chronic Kidney Disease Epidemiology
             Collaboration [CKD-EPI]) within 14 days prior to randomization.

         14. Must have absolute neutrophil count ≥ 1.5 x 10^9/L within 14 days prior to
             randomization.

         15. Must have platelet count ≥ 100 x 10^9/L within 14 days prior to randomization. Must
             not have required transfusion of platelets within 1 week of baseline platelet
             assessment.

         16. Patient must have adequate nutritional status with Body Mass Index (BMI) > 18 kg/m^2
             and body weight of > 40 kg with serum albumin > 3 g/dL.

         17. Other baseline laboratory evaluations, listed in Section 6.0, must be done within 14
             days prior to randomization.

         18. Patient must consent to provision of, and Investigator(s) must confirm access to and
             agree to submit a representative formalin fixed paraffin block of tumor tissue in
             order that the specific biomarker assays may be conducted. Submission of the tissue is
             to occur prior to randomization, unless approved by the Sponsor. Where local center
             regulations prohibit submission of blocks of tumor tissue, two 2 mm cores of tumor
             from the block and 10-30 unstained slides of whole sections of representative tumor
             tissue are preferred. Where two 2 mm cores of tumor from the block are unavailable,
             10-30 unstained slides of whole sections of representative tumor tissue alone are
             acceptable. Where no previously resected or biopsied tumor tissue exists or is
             available, on the approval of the Sponsor/designated CRO, the patient may still be
             considered eligible for the study.

         19. Patient must consent to provision of a sample of blood in order that the specific
             correlative marker assays may be conducted.

         20. Patients must be accessible for treatment and follow-up. Patients registered on this
             trial must receive protocol treatment and be followed at the participating center.
             This implies there must be reasonable geographical limits placed on patients being
             considered for this trial. Investigators must ensure that the patients randomized on
             this trial will be available for complete documentation of the treatment, response
             assessment, adverse events, and follow-up.

         21. Protocol treatment is to begin within 2 calendar days of patient randomization.

         22. The patient is not receiving therapy in a concurrent clinical study and the patient
             agrees not to participate in other interventional clinical studies during their
             participation in this trial while on study treatment. Patients participating in
             surveys or observational studies are eligible to participate in this study.

        Exclusion Criteria:

          1. Anti-cancer chemotherapy or biologic therapy if administered prior to the first
             planned dose of study medication (napabucasin or FOLFIRI) within period of time
             equivalent to the usual cycle length of the regimen. An exception is made for oral
             fluoropyrimidines (e.g. capecitabine, S-1), where a minimum of 10 days since last dose
             must be observed prior to the first planned dose of study medication. Standard dose of
             bevacizumab (5 mg/kg) may be administered prior to FOLFIRI infusion, per Investigator
             decision, for as long as permanent decision to include or exclude bevacizumab is made
             prior to patient randomization. Radiotherapy, immunotherapy (including immunotherapy
             administered for non-malignant diseaseneoplastic treatment purposes), or
             investigational agents within four weeks of first planned dose of study medication,
             with the exception of a single dose of radiation up to 8 Gy (equal to 800 RAD) with
             palliative intent for pain control up to 14 days before randomization.

          2. More than one prior chemotherapy regimen administered in the metastatic setting.

          3. Major surgery within 4 weeks prior to randomization.

          4. Patients with any known brain or leptomeningeal metastases are excluded, even if
             treated.

          5. Women who are pregnant or breastfeeding. Women should not breastfeed while taking
             study treatment and for 4 weeks after the last dose of napabucasin or while undergoing
             treatment with FOLFIRI and for 180 days after the last dose of FOLFIRI.

          6. Gastrointestinal disorder(s) which, in the opinion of the Qualified/Principal
             Investigator, would significantly impede the absorption of an oral agent (e.g.
             intestinal occlusion, active Crohn's disease, ulcerative colitis, extensive gastric
             and small intestine resection).

          7. Unable or unwilling to swallow napabucasin capsules daily.

          8. Prior treatment with napabucasin.

          9. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, clinically significant non-healing or healing wounds, symptomatic
             congestive heart failure, unstable angina pectoris, clinically significant cardiac
             arrhythmia, significant pulmonary disease (shortness of breath at rest or mild
             exertion), uncontrolled infection or psychiatric illness/social situations that would
             limit compliance with study requirements.

         10. Known hypersensitivity to 5-fluorouracil/leucovorin

         11. Known dihydropyrimidine dehydrogenase (DPD) deficiency

         12. Known hypersensitivity to irinotecan

         13. Chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis)

         14. Patients receiving treatment with St. John's wort or Phenytoin.

         15. Patients who plan to receive yellow fever vaccine during the course of the study
             treatment.

         16. Abnormal glucuronidation of bilirubin, known Gilbert's syndrome

         17. Patients with QTc interval > 470 milliseconds

         18. For patients to be treated with a regimen containing bevacizumab:

               -  History of cardiac disease: congestive heart failure (CHF) > New York Heart
                  Association (NYHA) Class II; active coronary artery disease, myocardial
                  infarction within 6 months prior to study entry; unevaluated new onset angina
                  within 3 months or unstable angina (angina symptoms at rest) or cardiac
                  arrhythmias requiring anti-arrhythmic therapy (beta blockers or digoxin are
                  permitted).

               -  Current uncontrolled hypertension (systolic blood pressure [BP] > 150 mmHg or
                  diastolic pressure > 90 mmHg despite optimal medical management) as well as prior
                  history of hypertensive crisis or hypertensive encephalopathy.

               -  History of arterial thrombotic or embolic events (within 6 months prior to study
                  entry)

               -  Significant vascular disease (e.g., aortic aneurysm, aortic dissection,
                  symptomatic peripheral vascular disease)

               -  Evidence of bleeding diathesis or clinically significant coagulopathy

               -  Major surgical procedure (including open biopsy, significant traumatic injury,
                  etc.) within 28 days, or anticipation of the need for major surgical procedure
                  during the course of the study as well as minor surgical procedure (excluding
                  placement of a vascular access device or bone marrow biopsy) within 7 days prior
                  to study enrollment

               -  Proteinuria at screening as demonstrated by urinalysis with proteinuria ≥ 2+
                  (patients discovered to have ≥2+ proteinuria on dipstick urinalysis at baseline
                  should undergo a 24 hour urine collection and must demonstrate ≤ 1g of protein in
                  24 hours to be eligible).

               -  History of abdominal fistula, gastrointestinal perforation, peptic ulcer, or
                  intra-abdominal abscess within 6 months

               -  Ongoing serious, non-healing wound, ulcer, or bone fracture

               -  Known hypersensitivity to any component of bevacizumab

               -  History of reversible posterior leukoencephalopathy syndrome (RPLS)

               -  History of hypersensitivity to Chinese hamster ovary (CHO) cells or other human
                  or humanized recombinant antibodies.

         19. Patients with a history of other malignancies except: adequately treated non-melanoma
             skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumors
             curatively treated with no evidence of disease for > 3 years.

         20. Any active disease condition which would render the protocol treatment dangerous or
             impair the ability of the patient to receive protocol therapy.

         21. Any condition (e.g. psychological, geographical, etc.) that does not permit compliance
             with the protocol.