Short Duration Therapy of Acute Hepatitis C Genotypes 1 or 4
Condition: Acute Hepatitis C; HIV
MeSH terms: Hepatitis A; Hepatitis C; Hepatitis
Intervention: Grazoprevir/Elbasvir
Intervention description: Once-daily, oral grazoprevir/elbasvir combination therapy at fixed-dose (100mg/50mg) for 8 weeks
Intervention MeSH terms: Grazoprevir; Elbasvir-grazoprevir drug combination
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 30.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      The purpose of this study is to assess the rate of sustained virological response (SVR) 12
      weeks after 8-week oral treatment with grazoprevir 100mg/elbasvir 50mg (MRK-combo) in
      patients with acute hepatitis C genotype1 or 4.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Adult ≥18 years.

          2. A recent acute HCV infection [defined by (i) detectable HCV RNA within 6 months after
             a negative HCV RNA or HCV serology test OR (ii) detectable HCV RNA and acute clinical
             hepatitis within 5 months prior to screening visit (ALT ≥250 IU/L with normal ALT
             within the preceding 8 months OR ALT ≥500 IU/L with either no measured ALT or with
             abnormal ALT within the preceding 8 months)] or reinfection [defined by documented de
             novo infection after prior clearance post-treatment (defined by one negative HCV RNA
             ≥6 months after end of treatment) or spontaneously (defined by two negative HCV RNA a
             minimum of 6 months apart OR documented infection with a new viral strain, confirmed
             by phylogenetic or genotypic analysis)] within 5 months prior screening OR (iii)
             patients having reported a risk factor for HCV contamination (traumatic sexual
             intercourse, intranasal, rectal or intravenous drug use) ≥6 months AND presenting a
             negative HCV RNA or HCV serology test within 12 months.

          3. Infection with HCV genotype 1 or 4 (confirmed at screening visit or by using a
             previous biological test performed 1 to 4 weeks before week 0).

          4. Plasma HCV-RNA ≥ 1000 IU/mL (confirmed at screening visit or by using a previous
             biological test performed 1 to 4 weeks before week 0).

          5. Confirmed HIV infection (only for HIV co-infected patients).

          6. Without HIV treatment or with an authorized stable HIV treatment for at least two
             weeks (only for HIV co-infected patients).

          7. Body weight ≥40 kg and ≤125 kg.

          8. Female patients with child-bearing potential and their heterosexual partners must use
             adequate contraception from the date of screening until 30 days after administration
             of the last dose of study drug. Male participants must agree to consistently and
             correctly use a condom, while their female partner must use adequate contraception
             from the date of screening until 30 days after administration of the last dose of
             study drug.

          9. Informed and signed consent.

         10. Patients with Health insurance (Sécurité Sociale or Couverture Médicale Universelle).

        Exclusion Criteria:

          1. Opportunistic infections (stage C), active or occurred within 6 months prior to
             baseline.

          2. Primary HIV infection.

          3. Co-infection with Hepatitis B virus (HBsAg-positive) without appropriate treatment
             (TDF or TAF) for at least 2 weeks.

          4. Confirmed cirrhosis (before acute HCV diagnosis).

          5. Any other causes of acute hepatitis.

          6. Pregnant or breast-feeding women.

          7. Liver transplant recipients.

          8. Evolutive malignancy.

          9. Patients with a history of non-adherence, who will be at risk of being unable to
             respect the study follow-up timetable.

         10. Patients participating in another clinical trial (with an experimental treatment) or
             within an exclusion period of a previous clinical trial at screening.

         11. Patients under legal gardianship or incarcerated.

         12. Hemaglobulin <10 g/dL (female) or <11g/dL (male).

         13. Platelet count <50,000/mm3.

         14. Neutrophil count < 750/mm3.

         15. Other antiretroviral drugs than those allowed in the study.

         16. Contra-indications to grazoprevir and/or elbasvir or to any of the excipients listed
             in the summary of the product characteristics.

         17. Contra-indicated treatment likely to interfere with the study drugs as listed in the
             summary of the product characteristics.