Maintenance Chemotherapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Chemotherapy for Stage IV Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II Trial
Condition: Stage IV Non-Small Cell Lung Cancer
MeSH terms: Lung Neoplasms; Carcinoma, Non-Small-Cell Lung
Intervention: Stereotactic Body Radiation Therapy; Maintenance chemotherapy
Intervention description: Maintenance chemotherapy
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 29.0
Sex: All
Minimum age: 18 Years
Maximum age: 99 Years
Healthy volunteers: No

Summary:

      The core hypothesis to be tested is that the use of consolidative SBRT followed by
      maintenance chemotherapy in patients with less than or equal to 6 metastatic sites (primary +
      5) will improve progression free survival (PFS) compared to maintenance chemotherapy alone.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Patients must have biopsy proven metastatic NSCLC (Stage IV).

          2. Patients must have received first line chemotherapy, from 4-6 cycles, and achieved
             stable disease or a partial response.

          3. Patients receiving first-line erlotinib, crizotinib for EGFR mutant-positive or
             EML4-ALK positive NSCLC will be excluded.

          4. Age ≥ 18 years

          5. Patients must have measurable disease at baseline.

          6. Patients can have up to only 6 discrete active extracranial lesions (≤3 in the liver
             and ≤3 in the lung) identified by diagnostic CT or PET/CT scan or MRI within 8 weeks
             prior to the initiation of SBRT.

               1. For patients who have received prior radiotherapy to the primary site in the
                  lung, residual PET activity is difficult to interpret and will not be considered
                  a site of active disease if the CT appearance is stable or improved over an
                  interval of at least three months

               2. Patients who previously received radiotherapy to the primary site will be
                  ineligible if there is CT evidence of disease progression within the past 3
                  months.

               3. Patients with previously un-irradiated primary sites will be potentially
                  eligible, but special considerations apply (section 4.3.2).

               4. Up to 2 contiguous vertebral metastases will be considered a single site of
                  disease.

          7. Patients must have a KPS >60

          8. AST, ALT & Alkaline phosphates must be ≤ 2.5X the upper limit of normal. Total
             bilirubin must be within the limit of normal.

          9. Patients should have adequate bone marrow function as defined by peripheral
             granulocyte count of ≥1500/mm³.

         10. Patients should have adequate renal function (serum creatinine ≤1.5 times the ULN).

         11. Women of child-bearing potential and men must agree to use adequate contraception
             (hormonal or barrier method of birth control; abstinence) prior to study entry, for
             the duration of study participation, and for 90 days following completion of therapy.
             Should a woman become pregnant or suspect she is pregnant while participating in this
             study, she should inform her treating physician immediately.

             11.1 A female of child-bearing potential is any woman (regardless of sexual
             orientation, having undergone a tubal ligation, or remaining celibate by choice) who
             meets the following criteria:

               -  Has not undergone a hysterectomy or bilateral oophorectomy; or

               -  Has not been naturally postmenopausal for at least 12 consecutive months (i.e.,
                  has had menses at any time in the preceding 12 consecutive months).

         12. Patients who would be receiving SBRT for lung tumors who are known or suspected by the
             treating radiation oncologist to have compromised lung function must have a documented
             forced expiratory volume in 1 second (FEV1) ≥ 1L.

         13. Patients must provide verbal and written informed consent to participate in the study.

        Exclusion Criteria:

          1. Patients who previously received radiotherapy to the primary site with CT evidence of
             disease progression at the primary site within 3 months following the initial
             radiotherapy.

          2. Patients with untreated brain metastases Patients with serious, uncontrolled,
             concurrent infection(s).

          3. Significant weight loss (>10%) in the prior 3 months.

          4. Because the tolerance dose of SBRT to the gastrointestinal tract is not established,
             patients with metastatic disease invading the esophagus, stomach, intestines, or
             mesenteric lymph nodes will not be eligible.

          5. Patients with cutaneous metastasis of NSCLC.

          6. Patients with more than 6 discrete extra-cranial lesions.

          7. Participation in any investigational drug study within 4 weeks preceding the start of
             study treatment.

          8. Unwillingness to participate or inability to comply with the protocol for the duration
             of the study.

          9. Patients who are pregnant. Patients with reproductive capability will need to use
             adequate contraception during the time of participation in the study.