In Vivo Preoperative Skin Preparation Efficacy Study Within a Defined Product Coverage Area
Condition: Surgical Skin Preparation; Surgical Procedure, Unspecified
Intervention: 3M CHG/IPA Prep
Intervention description: Apply topically to intact skin
Intervention MeSH terms: Ethanol; Chlorhexidine; Chlorhexidine gluconate
Phase: Phase 2
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 28.0
Sex: Male
Minimum age: 18 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: surgical skin prep; CHG; IPA

Summary:

      This study evaluates reduction of resident flora produced by the test product within a
      defined prepped area of skin.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Male subjects of any race who are at least 18 years of age,

          -  Subjects must have an area on their back region to accommodate the treatment coverage
             area,

          -  Subjects must be in good general health,

          -  Subjects who satisfy all inclusion/exclusion criteria and will voluntarily read and
             sign the Informed Consent Form,

          -  Subjects who have good skin condition on the test sites,

          -  Subjects who are willing to report to the study facility approximately 72 hours prior
             to Screening or Treatment Day for clipping, if needed,

          -  Subjects who are willing to avoid showering and tub-bathing within 72 hours prior to
             Screening and Treatment Days, and

          -  Subjects who have Screening Day baseline counts of > 3.00 log10 per cm2 in each of the
             3 sample sites (center, mid-peripheral and peripheral) in the treatment area (back
             region).

        Exclusion Criteria:

          -  Participation in another clinical study in the past 30 days, current participation in
             another clinical study, or previous participation in this study,

          -  Has taken antihistamines in the 48 hours prior to Treatment Day,

          -  Any tattoos, scars, breaks in the skin, or any form of dermatitis, or other skin
             disorders (including acne) on the applicable test areas,

          -  A history of skin allergies,

          -  A history of skin cancer within 6 inches of the test areas,

          -  Known sensitivity to acrylate-, chlorhexidine gluconate-, or alcohol-containing
             products, or to medical tape, metals, natural rubber latex, vinyl, or skin-marking
             inks,

          -  A medical diagnosis with physical condition that may put the subject at risk, such as
             a current or recent severe illness, hepatitis, organ transplant, congestive heart
             disease, or any immunocompromised conditions, such as AIDS (or HIV positive),

          -  Any medical condition or use of any medications that, in the opinion of the
             Investigator, should preclude participation,

          -  Topical antimicrobial exposure within 14 days prior to Screening Day and throughout
             the study. Restrictions include, but are not limited to antimicrobial soaps, medicated
             shampoos, medicated lotions, antiperspirants/deodorants, perfumes, after shaves, and
             colognes,

          -  Use of systemic or topical antibiotic medications, steroid medications, or any other
             product known to affect the normal microbial flora of the skin within 14 days prior to
             Screening Day and throughout the study,

          -  Exposure of the test areas to solvents, acids, bases, strong detergents, fabric
             softener-treated clothing, or other household chemicals within 14 days prior to
             Screening Day and throughout the study,

          -  Swimming in chemically treated pools or bathing in hot tubs, spas, or whirlpools
             within 14 days prior to Screening Day and throughout the study,

          -  Use of tanning beds, hot waxes, or depilatories (in the applicable test areas) within
             14 days prior to Screening Day and throughout the study

          -  Bathing and showering within 72 hours prior to Screening Day and throughout the study,
             or

          -  Subject has used moisturizers or any topical treatment (e.g. lotion, sunscreen or
             shaving cream) on the test sites in the 24-hour period prior to Screening Day and
             Treatment Day participation in the study.