Trial of Mitomycin C During Nephroureterectomy for Urothelial Carcinoma
Condition: Urothelial Carcinoma
MeSH terms: Carcinoma; Carcinoma, Transitional Cell
Intervention: Mitomycin c
Intervention description: All participants will receive a single 40 mg dose of mitomycin C intraoperatively during their scheduled nephroureterectomy. This single dose will be given through a catheter in the subject's bladder.
Intervention MeSH terms: Mitomycins; Mitomycin
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 29.0
Sex: All
Minimum age: 18 Years
Maximum age: 99 Years
Healthy volunteers: No

Summary:

      Results of previous studies suggest that the timing of intravesical mitomycin C
      administration may impact bladder tumor recurrence rate following radical nephroureterectomy.
      This is the first study of its kind to attempt to identify the importance of timing of
      mitomycin C administration relative to bladder tumor recurrence rate following radical
      nephroureterectomy.This study will investigate the one year bladder tumor recurrence rate in
      patients with urothelial carcinoma of the upper urinary tract following intraoperative
      administration of mitomycin C during a nephroureterectomy, as well as the time to bladder
      tumor recurrence in this patient population.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Both males and females ≥ eighteen years of age

          -  Clinical diagnosis of urothelial carcinoma of the renal pelvis and/or ureter. Clinical
             diagnosis of urothelial carcinoma may be based upon radiographic, pathologic or
             cytological findings alone or in combination with one another. No other histology is
             allowed.

          -  The TNM stage of the subject's disease (using the American Joint Committee on Cancer
             [AJCC] Cancer Staging Manual, 8th Edition) must be Tis, Ta, T1, T2, or T3, N0, M0.
             Subjects may have either a high-grade or low-grade tumor.

          -  ECOG performance status of 0-2

          -  Written informed consent obtained from the subject and the ability for the subject to
             comply with all the study-related procedures.

          -  Women of childbearing potential (WOCBP) must be using an adequate method of
             contraception to avoid pregnancy prior to and for at least 3 months after mitomycin C
             instillation to minimize the risk of pregnancy. Prior to study enrollment, women of
             childbearing potential must be advised of the importance of avoiding pregnancy during
             trial participation and the potential risk factors for an unintentional pregnancy.

          -  Males with female partners of child-bearing potential must agree to use
             physician-approved contraceptive methods (e.g., abstinence, condoms, vasectomy) should
             avoid conceiving children prior to and for 3 months following mitomycin C instillation

          -  Subjects must have hemoglobin ≥ 9 g/dL and a platelet count ≥ 100,000/μL.

        Exclusion Criteria:

          -  Active urothelial carcinoma of the bladder within 12 months prior to enrollment

          -  History of adverse reaction to mitomycin C

          -  Evidence of regional or metastatic disease.

          -  History of radical cystectomy

          -  Planned radical cystectomy at the time of nephroureterectomy

          -  Females or males of childbearing potential who are unwilling or unable to use an
             acceptable method to avoid pregnancy prior to and for at least 3 months after
             mitomycin C instillation.

          -  Females who are pregnant or breastfeeding.

          -  History of any other disease, metabolic dysfunction, physical examination finding, or
             clinical laboratory finding giving reasonable suspicion of a disease or condition that
             contraindicates the use of protocol therapy or that might affect the interpretation of
             the results of the study or that puts the subject at high risk for treatment
             complications, in the opinion of the treating physician.

          -  Prisoners or subjects who are involuntarily incarcerated.

          -  Subjects who are compulsorily detained for treatment of either a psychiatric or
             physical illness.

          -  Subjects demonstrating an inability to comply with the study and/or follow-up
             procedures