Pasireotide & Everolimus in Adult Patients With Radioiodine-Refractory Differentiated & Medullary Thyroid Cancer
Condition: Thyroid Cancer
MeSH terms: Thyroid Neoplasms; Thyroid Diseases
Intervention: Everolimus; Pasireotide; Everolimus and Pasireotide
Intervention description: Everolimus 10 mg daily continuously (switch to 2-drug combination at progression if no intolerable toxicity); Pasireotide 1200 mcg bid for 4 weeks followed by Pasireotide long acting release (LAR) 60 mg i.m. once every 4 weeks; Everolimus 10 mg daily continuously together with Pasireotide 1200 mcg bid for 4 weeks followed by Pasireotide long acting release (LAR) 60 mg i.m. once every 4 weeks
Intervention MeSH terms: Everolimus; Pasireotide; Somatostatin
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 42.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Thyroid Cancer

Summary:

      The purpose of this study is to determine the effectiveness of two anticancer drugs,
      everolimus and pasireotide, in patients with thyroid cancer when the cancer is no longer
      responding to treatment with radioiodine or where it is deemed unsafe for the patient to
      receive additional radioiodine treatment. The investigators also want to establish the best
      manner of taking the two medications when used together to treat thyroid cancer. In
      particular, the investigators want to know if it is better to give both at the same time or
      add a second medication after the first one has stopped working.

      This study will also look at specific substances called biomarkers in your blood, and in the
      tumor tissue which are involved in the growth of tumor cells, and determine if the levels of
      these biomarkers are related to your response to treatment or development of side effects.

      Everolimus, also known by the brand name, Afinitor, is a biologic drug approved by the Food
      and Drug Administration (FDA) for the treatment of kidney cancer. It works by preventing
      cancer cells from multiplying and it also makes them more likely to die from the treatment.

      Pasireotide also known by the name, SOM230 is a new medication that is not yet approved by
      the FDA for the treatment of cancer. It is a newer form of a drug called octreotide, which is
      approved for the treatment of cancer arising from endocrine organs. Pasireotide works by
      binding to a protein called somatostatin receptor, which is expressed in many tissues
      throughout the body including thyroid cancer cells. Pasireotide prevents the action of
      somatostatin by binding to these receptors.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Histologic or cytologic confirmation of thyroid cancer (papillary, follicular,
             medullary); histologic variants such as Hurthle and tall cell variants are allowed.

          2. Biochemical or radiologic documentation of disease progression within the last 12
             months prior to enrollment.

          3. Presence of at least one site of measurable disease according to Response Evaluation
             Criteria in Solid Tumors (RECIST) criteria version 1.1.

          4. Patient must have radioiodine refractory disease as defined by one or more of the
             following conditions:

               -  All cases of medullary thyroid carcinoma.

               -  No iodine-uptake on a post- radioactive iodine treatment scan (in presence of low
                  iodine diet and thyroid stimulating hormone (TSH) suppression) in an anatomically
                  defined lesion that qualifies as target lesion by RECIST criteria.

             OR

             • If there is demonstrable iodine-uptake: the last radioiodine therapy of (≥ 100 mCi)
             was given within the last 16 months OR if given more than 16 months before enrollment,
             there is evidence of disease progression after each of the last two radioiodine
             treatment performed within 16 months of each other (each dose should be ≥ 100mCi).

             OR

               -  If the patient has received the maximum cumulative life time dose of radioactive
                  iodine treatments of at least 600 mCi.

               -  If the patient declines or is intolerant of radioiodine therapy or if with
                  progressive disease that is, in the opinion of the treating physician, likely to
                  benefit from biologic therapy rather than further iodine therapy e.g. patient
                  with heavy burden of disease

          5. Age ≥ 18 years.

          6. Minimum of four weeks since any major surgery or since completion of radiation
             (patients should have adequately recovered from the acute toxicities of any prior
             therapy).

          7. Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2.

          8. Life expectancy of at least 6 months.

          9. Adequate bone marrow function as shown by: absolute neutrophil count (ANC) ≥ 1.5 x
             10⁹/L, platelets ≥ 100 x 10⁹/L, Hgb > 9 g/dL.

         10. Adequate liver function as shown by: serum bilirubin ≤ 1.5 x upper limit of normal
             (ULN), and serum transaminases activity ≤ 3 x ULN, with the exception of serum
             transaminases (< 5 x ULN) if the patient has liver metastases.

         11. Adequate renal function as shown by serum creatinine ≤ 1.5 x ULN or glomerular
             filtration rate (GFR) of 60cc/ml using the formula of Cockroft and Gault.

         12. Fasting serum cholesterol ≤ 300 mg/dL OR ≤ 7.75 mmol/L AND fasting triglycerides ≤ 2.5
             x ULN. NOTE: In case one or both of these thresholds are exceeded, the patient can
             only be included after initiation of appropriate lipid lowering medication.

         13. Women of childbearing potential must have a negative serum pregnancy test within 14
             days of the administration of the first study treatment. Women must not be lactating.
             Both men and women of childbearing potential must be advised of the importance of
             using effective birth control measures during the course of the study.

         14. Signed informed consent to participate in the study must be obtained from patients
             after they have been fully informed of the nature and potential risks by the
             investigator (or his/her designee) with the aid of written information.

         15. International normalized ratio (INR) and prothrombin time (PTT) ≤ 1.5 x ULN.
             (Anticoagulation is allowed if target INR ≤ 1.5 on a stable dose of warfarin or on a
             stable dose of low molecular weight [LMW] heparin for > 2 weeks at time of
             randomization.)

        Exclusion Criteria:

          1. Prior treatment with not more than 1 systemic agent.

          2. Patients who have undergone major surgery within 4 weeks prior to study enrollment
             (tracheotomy, feeding tube or vascular access catheter placement and interventional
             procedures such as bronchoscopy, upper GI endoscopy or colonoscopy are not considered
             major surgery).

          3. Chronic treatment with systemic steroids or another immunosuppressive agent.

          4. Patients should not receive immunization with attenuated live vaccines during study
             period or within 1 week of study entry.

          5. Uncontrolled brain or leptomeningeal metastases, including patients who continue to
             require glucocorticoids for brain or leptomeningeal metastases.

          6. Patients with prior or concurrent malignancy except for the following: adequately
             treated basal cell or squamous cell skin cancer, or other adequately treated in situ
             cancer, or any other cancer from which the patient has been disease free for five
             years.

          7. Patients with uncontrolled diabetes mellitus or a fasting plasma glucose > 1.5 ULN.
             Note: At the principal investigator's discretion, non-eligible patients can be
             re-screened after adequate medical therapy has been instituted.

          8. Patients with symptomatic cholelithiasis (asymptomatic gall stone discovered on
             screening US should be reviewed by the PI but will not lead to automatic exclusion).

          9. Liver disease such as cirrhosis or severe hepatic impairment (Child-Pugh class C):

               -  History of liver disease, such as cirrhosis or chronic active hepatitis B and C.

               -  Presence of Hepatitis B surface antigen (HbsAg).

               -  Presence of Hepatitis C antibody test (anti-HCV).

         10. Patients who have congestive heart failure (NYHA Class III or IV), unstable angina,
             sustained ventricular tachycardia, ventricular fibrillation, clinically significant
             bradycardia, advanced heart block or a history of acute myocardial infarction within
             the six months preceding enrollment.

         11. QT related exclusion criteria:

               -  QT corrected Fridericia's method (QTcF) at screening > 470 msec.

               -  History of syncope or family history of idiopathic sudden death.

               -  Sustained or clinically significant cardiac arrhythmias.

               -  Risk factors for Torsades de Pointes such as hypokalemia, hypomagnesemia, cardiac
                  failure, clinically significant/symptomatic bradycardia, or high-grade
                  atrioventricular (AV) block.

               -  Concomitant disease(s) that could prolong QT such as autonomic neuropathy (caused
                  by diabetes, or Parkinson's disease), HIV, cirrhosis, uncontrolled hypothyroidism
                  or cardiac failure.

               -  Concomitant medication(s) known to increase the QT interval.

         12. Patients with the presence of active or suspected acute or chronic uncontrolled
             infection or with a history of immunocompromise, including a positive HIV test result
             (ELISA and Western blot).

         13. Patients who have any severe and/or uncontrolled medical conditions or other
             conditions that could affect their participation in the study such as:

               -  Severely impaired lung function (as defined as spirometry and diffusing capacity
                  of lung for carbon monoxide [DLCO] that is 50% of the normal predicted value
                  and/or 02 saturation that is 88% or less at rest on room air).

               -  Any active (acute or chronic) or uncontrolled infection/disorders.

               -  Nonmalignant medical illnesses that are uncontrolled or whose control may be
                  jeopardized by the treatment with the study therapy.

               -  Impairment of gastrointestinal function or gastrointestinal disease that may
                  significantly alter the absorption of RAD001 (everolimus).

               -  Patients who have a history of alcohol or drug abuse in the 6 month period prior
                  to receiving treatment with pasireotide or RAD001.

               -  History of, or current alcohol misuse/abuse within the past 12 months.

               -  Acute or chronic pancreatitis.

         14. Women who are pregnant or breast feeding, or women/men of reproductive potential who
             are not using and unwilling to practice an effective method of birth control. (Women
             of childbearing potential [WOCBP] must have a negative serum pregnancy test within 7
             days prior to administration of pasireotide and RAD001.)

         15. Male patient whose sexual partner(s) are WOCBP who are not willing to use adequate
             contraception, during the study and for 8 weeks after the end of treatment.

         16. Patients with a known hypersensitivity to RAD001 (everolimus) or other rapamycins
             (sirolimus, temsirolimus) or to its excipients.

         17. Known hypersensitivity to somatostatin analogues or any component of the pasireotide
             or octreotide LAR formulations.

         18. History of noncompliance to medical regimens.

         19. Patients unwilling to or unable to comply with the protocol.

         20. Patients taking medications known to be strong cytochrome P450, family 3, subfamily A
             (CYP3A) inhibitors.