A Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1)
Condition: Graft-versus-host Disease (GVHD)
MeSH terms: Graft vs Host Disease
Intervention: Ruxolitinib; Prednisone or methylprednisolone
Intervention description: Either oral prednisone or IV methylprednisolone may be used to begin corticosteroid treatment at the investigator's discretion.
Intervention MeSH terms: Prednisone; Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 71.0
Sex: All
Minimum age: 12 Years
Healthy volunteers: No
Keywords: Graft-versus-host disease (GVHD); acute GVHD; steroid-refractory; ruxolitinib; Janus kinase inhibitor

Summary:

      The purpose of this study was to assess the efficacy of ruxolitinib in combination with
      corticosteroids in subjects with Grades II to IV steroid-refractory acute graft-versus-host
      disease (GVHD).
    

Eligibility criteria:

        Inclusion Criteria:

          -  Have undergone first allogeneic hematopoietic stem cell transplantation (allo-HSCT)
             from any donor source using bone marrow, peripheral blood stem cells, or cord blood
             for hematologic malignancies. Recipients of nonmyeloablative and myeloablative
             conditioning regimens are eligible.

          -  Clinically suspected Grades II to IV acute GVHD as per MAGIC guidelines, occurring
             after allo-HSCT with any conditioning regimen and any anti-GVHD prophylactic program.

          -  Subjects with steroid-refractory acute GVHD, defined as any of the following:

               -  Subjects with progressive GVHD (ie, increase in stage in any organ system or any
                  new organ involvement) after 3 days of primary treatment with methylprednisolone
                  ≥ 2 mg/kg per day (or equivalent).

               -  Subjects with GVHD that has not improved (ie, decrease in stage in at least 1
                  involved organ system) after 7 days of primary treatment with methylprednisolone
                  ≥ 2 mg/kg per day (or equivalent).

               -  Subjects who previously began corticosteroid therapy at a lower dose (at least 1
                  mg/kg per day methylprednisolone) but develop new GVHD in another organ system.

               -  Subjects who cannot tolerate a corticosteroid taper, that is, begin
                  corticosteroids at 2.0 mg/kg per day, demonstrate response, but progress before a
                  50% decrease from the initial starting dose of corticosteroids is achieved.

          -  Evidence of myeloid engraftment (eg, absolute neutrophil count ≥ 0.5 × 10^9/L for 3
             consecutive days if ablative therapy was previously used). Use of growth factor
             supplementation is allowed.

          -  Be willing to avoid pregnancy or fathering children

        Exclusion Criteria:

          -  Has received more than 1 allo-HSCT.

          -  Has received more than 1 systemic treatment in addition to corticosteroids for acute
             GVHD.

          -  Presence of GVHD overlap syndrome as per NIH guidelines.

          -  Subjects who have had a splenectomy.

          -  Presence of an active uncontrolled infection. An active uncontrolled infection is
             defined as hemodynamic instability attributable to sepsis or new symptoms, worsening
             physical signs, or radiographic findings attributable to infection. Persisting fever
             without signs or symptoms will not be interpreted as an active uncontrolled infection.

          -  Known human immunodeficiency virus infection.

          -  Active hepatitis B virus (HBV) or hepatitis C virus infection that requires treatment
             or at risk for HBV reactivation. Subjects whose immune status is unknown or uncertain
             must have results confirming immune status before enrollment.

          -  Serum creatinine > 2.0 mg/dL or creatinine clearance < 40 mL/min measured or
             calculated by Cockcroft-Gault equation.

          -  Subjects with evidence of relapsed primary disease, or subjects who have been treated
             for relapse after the allo-HSCT was performed.

          -  Unresolved toxicity or complications (other than acute GVHD) due to previous
             allo-HSCT.

          -  Any corticosteroid therapy for indications other than GVHD at doses of
             methylprednisolone or equivalent > 1 mg/kg per day within 7 days of enrollment.

          -  Severe organ dysfunction unrelated to underlying GVHD, including:

               -  Cholestatic disorders or unresolved veno-occlusive disease of the liver (defined
                  as persistent bilirubin abnormalities not attributable to GVHD and ongoing organ
                  dysfunction).

               -  Clinically significant or uncontrolled cardiac disease including unstable angina,
                  acute myocardial infarction within 6 months from Day 1 of study drug
                  administration, New York Heart Association Class III or IV congestive heart
                  failure, circulatory collapse requiring vasopressor or inotropic support, or
                  arrhythmia that requires therapy.

               -  Clinically significant respiratory disease that requires mechanical ventilation
                  support or 50% oxygen.

          -  Currently breast feeding.

          -  Received Janus kinase inhibitor (JAK) therapy after allo-HSCT for any indication.
             Treatment with a JAK inhibitor before allo-HSCT is permitted.

          -  Treatment with any other investigational agent, device, or procedure, within 21 days
             (or 5 half-lives, whichever is greater) of enrollment. Subjects participating in a
             GVHD prophylaxis study or conditioning regimen should be discussed with the sponsor's
             medical monitor before enrollment.

          -  Any condition that would, in the investigator's judgment, interfere with full
             participation in the study, including administration of study drug and attending
             required study visits; pose a significant risk to the subject; or interfere with
             interpretation of study data.

          -  Known allergies, hypersensitivity, or intolerance to any of the study medications,
             excipients, or similar compounds.