Study of PNT2258 for Treatment of Relapsed or Refractory Non-Hodgkin's Lymphoma
Condition: Lymphoma, Non-Hodgkin's
MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin
Intervention: PNT2258
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 13.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: PNT2258; Lymphoma; Non-Hodgkin's Lymphoma; NHL

Summary:

      This study is sponsored by Sierra Oncology, Inc. formerly ProNAi Therapeutics, Inc. It study
      is a multi-center, nonrandomized, open-label, pilot Phase II investigation of PNT2258 to
      characterize anti-tumor activity and collect safety data on patients with relapsed or
      refractory lymphoma.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Written informed consent must be obtained from the patient.

          2. Participants must be ≥18 years of age.

          3. Morphologically confirmed diagnosis of non-Hodgkin's lymphoma (NHL).

          4. At least a single measureable tumor mass (long axis > 1.5 cm).

          5. An FDG-PET positive baseline scan.

             a. A positive scan is defined per revised Cheson criteria as "focal or diffuse FDG
             uptake above background in a location incompatible with normal anatomy or physiology,
             without a specific standardized uptake value cutoff".

          6. Disease that has relapsed after administration of primary therapy that included:

               1. Rituximab and

               2. CHOP, EPOCH, bendamustine or similar chemotherapy or subsequent salvage regimen.

             Note: Relapse is defined as progression after a complete response to therapy or
             radiographic evidence of active disease after a partial response or stable disease.

          7. Have received three or fewer complete courses of systemic cytotoxic regimens. Note:
             Rituximab (alone or in combination with cytotoxic chemotherapy) is not considered a
             cytotoxic regimen.

          8. No previous exposure to PNT2258.

          9. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.

         10. Have discontinued all prior anti-cancer therapies for at least 21 days; biologic
             therapy for at least 4 half-lives of the drug(s); radio-immunotherapy (10 weeks);
             autologous stem cell transplantation (SCT) (3 months) and must be at a stable baseline
             regarding any acute toxicity associated with prior therapy.

         11. Adequate organ function including:

               1. Hematologic Function: absolute neutrophil count (ANC) ≥ 1.5 x 109/L prior to
                  treatment. Platelets ≥ 100 x 109/L.

               2. Hepatic: Total Bilirubin ≤ 1.5 x ULN and serum transaminase levels ≤ 2.5 x upper
                  limits of normal (ULN).

               3. Renal: Serum creatinine ≤2 x ULN or creatinine clearance ≥ 60 mL/min/1.73 m2 for
                  subjects with serum creatinine levels above 2x ULN.

        Exclusion Criteria:

          1. Candidates for HDT and autologous SCT. Note: Patients who progressed > 3 months after
             high-dose therapy (HDT)/SCT are eligible.

          2. Concurrent malignancies requiring treatment.

          3. Symptomatic central nervous system (CNS) or leptomeningeal involvement of lymphoma.

          4. Concurrent serious medical conditions (as determined by the Principal Investigator)
             including, but not limited to, HIV-associated lymphoma; active bacterial, fungal or
             viral infections.

          5. Signs and symptoms of heart failure characterized as greater than New York Heart
             Association (NYHA) Class I.

          6. History of myocardial infarct or prolonged corrected QT (QTc) interval (>450
             milliseconds (msecs) for males or >470 msecs for females) or other significant cardiac
             abnormalities.

          7. Women who are pregnant or breast-feeding.