The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy
Condition: Painful Diabetic Neuropathy; Diabetic Neuropathy; Neuropathy
MeSH terms: Peripheral Nervous System Diseases; Diabetic Neuropathies; Pain
Intervention: Clonidine Hydrochloride Topical Gel, 0.1%; Clonidine Hydrochloride Gel Comparator
Intervention description: Clonidine Gel is supplied as an aqueous gel formulation for topical use.; Clonidine Gel Comparator is supplied as an aqueous gel formulation for topical use.
Intervention MeSH terms: Clonidine
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Enrollment: 138.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Diabetes Mellitus; Pain; Foot Pain; Neuropathy

Summary:

      The study will include three (3) phases: Screening Phase, Treatment Phase, and Follow-up
      Phase. Subjects who qualify to participate will apply study drug to their feet three times
      daily and will record their daily pain scores using an interactive voice response system
      (IVRS) during the Treatment Phase for 12 weeks. Approximately 100 adult subjects will be
      randomized to receive Clonidine Gel or Clonidine Gel Comparator.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Subject is fluent in English and has provided written informed consent.

          2. Subject is an outpatient ≥18 years of age at the time of the Screening Visit.

          3. Subject has Type 1 or Type 2 diabetes mellitus with a hemoglobin A1C value < 10% and
             has been stable on therapy (diet, oral anti-hyperglycemic, and/or insulin) for at
             least six (6) months prior to the Screening Visit.

          4. Subject is a male or non-pregnant, non-lactating female. Females must be practicing an
             acceptable method of birth control or be surgically sterile or postmenopausal
             (amenorrhea for ≥12 months). A negative pregnancy test at the Screening and Day 1
             visits is required for females of child-bearing potential. Double-barrier methods,
             hormonal contraceptives, and abstinence are acceptable birth control methods for this
             study.

          5. Subject has chronic pain attributable to a symmetrical stocking distribution
             neuropathy in the lower extremities for at least six (6) months. Pain should be
             clearly localized to the area of neuropathy (feet), and subjects should be able to
             distinguish the target pain from other painful areas and conditions.

          6. Subject has an average pain score relevant to the target pain in the feet of ≥4 on an
             11 point numerical pain rating scale over the previous 24 hours at the Screening
             Visit.

          7. Subject meets a pre-specified, minimum numerical pain rating scale score following
             capsaicin skin challenge.

          8. Subject must satisfactorily complete Accurate Pain Reporting and Minimizing Placebo
             Response Training.

          9. Subject must have moderate to severe pain during the Screening Run-in Phase.

         10. Subjects must be 75 to 110% compliant with application of study drug during the
             Screening Run-in Phase

         11. Subject has been medically stable for at least 30 days prior to the Screening Visit,
             and in the opinion of the Investigator, is in otherwise good general health based on
             medical history, physical examination, electrocardiogram, and laboratory evaluation.

        Exclusion Criteria:

          1. Subject has neuropathy secondary to non-diabetic causes in the opinion of the
             Investigator (e.g., vasculitis, familial neuropathy, alcoholism, pernicious anemia,
             hepatitis, malignancy, chronic inflammatory demyelinating polyneuropathy [CIDP], human
             immunodeficiency virus [HIV], medication-induced neuropathy, vitamin B12 deficiency).

          2. Subject has a significant neurological disorder or condition that might confound
             assessment of painful diabetic neuropathy (e.g., stroke with distal neurological
             deficit, mononeuritis multiplex, lumbar radiculopathy).

          3. Subject has a confounding disorder as determined by the Algorithm for Excluding
             Disorders that Masquerade as Painful Diabetic Neuropathy.

          4. Subject has other sustained pain with intensity at or greater than the bilateral
             neuropathic pain in the feet.

          5. Subject is using an implanted medical device (e.g., spinal cord stimulator,
             intrathecal pump, or peripheral nerve stimulator) for treatment of pain.

          6. Subject is hypotensive with a resting diastolic blood pressure <60 mm Hg or a systolic
             blood pressure <90 mm Hg at the Screening or Day 1 Visit.

          7. The subject has recent history (within the past 3 months) or current symptoms of
             orthostatic hypotension.

          8. Subject has a history of foot or toe amputation or an active foot or toe ulcer.

          9. Subject has any significant or unstable medical or psychiatric condition that, in the
             opinion of the Investigator, would interfere with his/her ability to participate in
             the study.

         10. Subject has a history of substance abuse disorder as defined by the Diagnostic and
             Statistical Manual of Mental Disorders, 5th Edition, within the past year, has current
             evidence of substance abuse disorder, is receiving medical treatment for drug abuse,
             or has a positive urine drug screen for a non-prescribed substance of abuse.

         11. Subject is receiving or has received within 30 days prior to the Screening Visit any
             prohibited medications or is anticipated to receive after the start of the trial any
             new prescription medication for their painful diabetic neuropathy. Subjects may be
             enrolled if stable on therapy for painful diabetic neuropathy.

         12. Subject has symptomatic or severe coronary insufficiency, clinically significant
             cardiac conduction disturbances, myocardial infarction (within last 12 months),
             moderate to severe cerebrovascular disease, or severe chronic obstructive pulmonary
             disease (COPD).

         13. Subject has estimated creatinine clearance less than 50 mL/min (Cockcroft Gault) at
             the Screening Visit.

         14. Subject has serum alanine transaminase (ALT) or aspartate transaminase (AST) >3.0
             times the upper limit of normal or total bilirubin concentrations >2.0 times the upper
             limit of normal at the Screening Visit.

         15. Subject has received an investigational drug within 30 days prior to the Screening
             Visit.

         16. Subject has been treated previously with clonidine topical gel or participated in a
             clonidine topical gel clinical study, including Study CLO 290.

         17. Subject is currently taking or has taken clonidine (any formulation) over the past 4
             weeks.

         18. Subject has known hypersensitivity or intolerance to clonidine.

         19. Subject is receiving or has received ≤7 days prior to the start of the Screening Phase
             "alternative medicine" products or treatments (e.g., acupuncture, naturopathy,
             homeopathy, etc.) for management of pain.

         20. Subject has a history of malignancy within the past 5 years except for successfully
             treated non-metastatic basal cell or squamous cell carcinomas of the skin and/or
             localized carcinoma in situ of the cervix.

         21. Subject is planning to have surgery during the course of the study.

         22. Subject has significant skin changes on physical examination associated with either
             pedal edema or venous stasis disease.

         23. Subject has any dermatologic condition of the lower extremities that could affect
             study drug absorption

         24. Subject has current symptoms of depression with a Beck Depression Inventory II (BDI
             II) score >19 at the Screening Visit.