Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas
Condition: Neurofibromatosis Type 2; Vestibular Schwannomas
MeSH terms: Neurofibromatoses; Neurofibromatosis 1; Neurofibroma; Neurilemmoma; Neuroma, Acoustic; Neurofibromatosis 2
Intervention: Axitinib
Intervention MeSH terms: Axitinib
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 13.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Neurofibromatosis Type 2; Vestibular Schwannomas; Axitinib

Summary:

      The purpose of this study is to determine if the study drug, AXITINIB, has any effect on
      tumors found in patients with Neurofibromatosis Type 2 (NF2).
    

Eligibility criteria:

        Inclusion criteria

          -  Age ≥18 years

          -  Meets clinical diagnostic criteria for NF2

          -  At least one volumetrically measurable and ≥1 cc NF2-related VS (histological
             confirmation not required)

          -  MRI evidence of progression (either as >2 mm increase in maximum linear diameter on
             conventional MRI, or a >20%volume increase by 3D volumetrics) over the past ≤18
             months, OR progressive hearing loss, defined as a decline in word recognition score
             below the 95% critical difference interval from baseline score related to VS (i.e.,
             not due to prior interventions such as surgery or radiation)

          -  Karnofsky performance status (PS) 60-100%. Note: Patients who are unable to walk
             because of paralysis, but who are up in a wheelchair, will be considered ambulatory
             for the purpose of assessing the performance score.

          -  Adequate bone marrow function as shown by: absolute neutrophil count ≥1.5 x 10^9/L,
             Platelets ≥100 x 10^9/L, Hb >9 g/dL

          -  Adequate liver function as shown by:

          -  serum bilirubin ≤1.5 x upper limit of normal (ULN)

          -  ALT and AST ≤2.5x ULN

          -  INR ≤1.5. (anticoagulation with low molecular weight heparin is allowed if on a stable
             dose for >2 weeks at time of enrollment.)

          -  Adequate renal function: serum creatinine ≤1.5 x ULN

          -  Fully recovered from acute toxic effects of any prior chemotherapy, biological
             modifiers or radiotherapy

          -  Any neurologic deficits must be stable for ≥1 week

          -  Able to provide signed informed consent Exclusion criteria

          -  Patients currently receiving medical anticancer therapies or who have received medical
             anticancer therapies within 4 weeks of the start of study drug (including
             chemotherapy, antibody based therapy, etc.)

          -  Radiation therapy to a study target tumor within 1 year prior to enrollment, or any
             radiation therapy within 4 weeks prior to enrollment.

          -  Patients who have had a major surgery or significant traumatic injury within 4 weeks
             of start of study drug, patients who have not recovered from the side effects of any
             major surgery (defined as requiring general anesthesia) or patients that may require
             major surgery during the course of the study

          -  Prior treatment with bevacizumab or other agents targeting vascular endothelial growth
             factor (VEGF) or VEGF receptor

          -  Prior treatment with any investigational drug within the preceding 4 weeks

          -  Unstable or rapidly progressive disease, including patients who require
             glucocorticoids for symptomatic control of brain or spinal tumors

          -  Treatment with strong CYP3A4 enzyme inhibitors or inducers, including but not limited
             to ketoconazole, itraconazole, ritonavir, phenytoin, carbamazepine, rifampin,
             rifabutin, phenobarbital and St. John's wort

          -  Requirement of therapeutic anticoagulant therapy with oral vitamin K antagonists;
             low-dose anticoagulants for maintenance of patency of central venous access devise or
             prevention of deep venous thrombosis is allowed; therapeutic use of low molecular
             weight heparin (or similar parenteral drug) for venous-thromboembolic disease is
             allowed.

          -  Other malignancies within the past 3 years except for adequately treated carcinoma of
             the cervix or basal or squamous cell carcinomas of the skin.

          -  Patients who have any severe and/or uncontrolled medical conditions or other
             conditions that could affect their participation in the study such as:

          -  Symptomatic congestive heart failure of New York heart Association Class III or IV

          -  unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction
             within 6 months of start of study drug, serious uncontrolled cardiac arrhythmia or any
             other clinically significant cardiac disease

          -  severely impaired lung function as defined as spirometry and diffusion capacity of
             lung for carbon monoxide (DLCO) that is 50% of the normal predicted value and/or O2
             saturation that is 90% or less at rest on room air

          -  active (acute or chronic) or uncontrolled severe infections

          -  liver disease such as cirrhosis or severe hepatic impairment (Child-Pugh class C).

          -  Impairment of gastrointestinal function or gastrointestinal disease that may
             significantly alter the absorption of axitinib (e.g., ulcerative disease, uncontrolled
             nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)

          -  Patients with an active bleeding diathesis

          -  Female patients who are pregnant or breast feeding, or adults of reproductive
             potential who are not using effective birth control methods. Adequate contraception
             must be used throughout the trial and for 8 weeks after the last dose of study drug,
             by both sexes. (Females of childbearing potential must have a negative serum pregnancy
             test within 7 days prior to administration of axitinib)

          -  Male patient whose sexual partner(s) are women of child bearing potential, who are not
             willing to use adequate contraception, during the study and for 8 weeks after the end
             of treatment

          -  History of noncompliance to medical regimens

          -  Patients unwilling to or unable to comply with the protocol