Sunitinib in Never-Smokers With Lung Adenocarcinoma
Condition: Lung Cancer
MeSH terms: Adenocarcinoma; Adenocarcinoma of Lung
Intervention: Sunitinib
Intervention MeSH terms: Sunitinib
Phase: Phase 2
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 13.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No

Summary:

      This research study is a Phase II clinical trial, which tests the safety and effectiveness of
      an investigational drug to learn whether the drug works in treating a specific cancer.
      "Investigational" means that the drug is being studied. It also means that the FDA has not
      yet approved sunitinib for your type of cancer.

      Sunitinib has been approved by the FDA for treatment of gastrointestinal stromal tumors,
      advanced renal cell carcinoma and advanced pancreatic neuroendocrine tumors. While most
      chemotherapies work by interfering with cancer cell replication, sunitinib works by blocking
      certain protein signals within the cell. Because sunitinib works differently from standard
      intravenous chemotherapies, we call it a "targeted therapy." This drug has also been used in
      other research studies and information from those other research studies suggests that this
      agent may help to slow the growth of some NSCLC tumors.

      In this research study, we are looking to see if sunitinib may stop certain NSCLC tumors from
      growing. The study focuses on a type of NSCLC, adenocarcinoma, which has previously been
      found to be more sensitive to other kinds of oral targeted therapies. This study will focus
      specifically on (1) adenocarcinoma tumors that do not carry a mutation in a known cancer gene
      (EGFR, KRAS, or ALK) and occur in patients that never smoked (less than 100 cigarettes in
      their lifetime) or (2) adenocarcinoma tumors that have a mutation in the RET gene.
    

Eligibility criteria:

        Inclusion Criteria:

          -  Histologically or cytologically confirmed advanced (stage IV or recurrent) non-small
             cell lung cancer

          -  Adenocarcinoma histology of any variant, including adenosquamous histology

          -  Wild-type for mutations in EGFR, KRAS and ALK

          -  Must have < 100 cigarettes smoked lifetime OR known to harbor a RET rearrangement OR
             another potentially targetable genomic alteration as defined per protocol

          -  Disease must be measureable per RECIST 1.1

          -  At least one prior systemic therapy (adjuvant or palliative)

          -  18 years or older

          -  Life expectancy of greater than 4 weeks

          -  Adequate ECOG performance status 0 or 1

          -  Adequate organ function as defined in the protocol

          -  Adequate tumor tissue for the correlative analyses on study, or must undergo a biopsy
             to obtain adequate tissue

        Exclusion Criteria:

          -  Pregnant or breastfeeding

          -  Chemotherapy within 4 weeks of entering study, or lack of recover from adverse events
             to grade 1 or less due to systemic agents administered more than 4 weeks earlier

          -  Radiation therapy within 2 weeks prior to entering study

          -  Major surgery within 4 weeks prior to entering the study

          -  Receiving any other investigational agents

          -  Known untreated, symptomatic or progressive brain metastases; presence of
             carcinomatous meningitis; history of intracranial hemorrhage or brain metastases
             requiring chronic steroids

          -  History of allergic reactions attributed to compounds of similar chemical or biologic
             composition to sunitinib

          -  Use of certain inhibitors and inducers of CYP3A4

          -  Grade 3 or 4 hemoptysis or hemorrhage within 4 weeks prior to study entry

          -  History of significant bleeding disorder unrelated to cancer

          -  Poorly controlled hypertension

          -  Severe cardiovascular disease

          -  Prolongation of corrected QT interval

          -  History of a different malignancy except: cervical cancer in situ, basal or squamous
             cell carcinoma of the skin, low risk centralized prostate cancer

          -  HIV positive on combination antiretroviral therapy