ATX-GD-59 in Patients With Graves Disease Not Treated With Anti-thyroid Therapy
Condition: Graves Disease
MeSH terms: Graves Disease
Intervention: ATX-GD-59
Intervention description: Disease specific immune modulating treatment for Graves Disease
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 12.0
Sex: All
Minimum age: 18 Years
Maximum age: 65 Years
Healthy volunteers: No
Keywords: Graves Disease; Phase 1

Summary:

      Phase 1 study to assess the safety and biological activity of ATX-GD-59 in patients with
      Graves Disease not currently treated with anti-thyroid therapy. This will be an open label
      dose titration involving injections on 10 occasions, each two weeks apart. After dosing is
      complete there will be a 12 week follow up period. Blood samples will be drawn throughout the
      study to monitor safety and the body's response to the injections. Thyroid function will be
      measured throughout the trial to monitor Graves disease progression.
    

Eligibility criteria:

        Inclusion Criteria:

          1. A diagnosis of Graves' disease as assessed by a physician from clinical and laboratory
             findings and not receiving anti-thyroid therapy.

          2. Quantifiable levels of TSHR antibodies.

          3. Raised levels of free T3 and/or free T4 (not exceeding 15 pmol/L and 35 pmol/L
             respectively) including undetectable levels of thyroid stimulating hormone.

          4. HLA-DRB1*15, HLA DRB1*03 and or HLA DRB1*04 positive.

          5. Age 18 - 65 years inclusive at the time of informed consent.

          6. The subject must be willing and able to give written informed consent and must be
             willing to comply with protocol assessments/procedures.

          7. Male subjects must be sterile (biologically or surgically) or commit to the use of a
             reliable method of birth control for the duration of the study until at least 90 days
             after the last dose of ATX-GD-59.

          8. Female subjects of child bearing potential must: - neither be pregnant nor
             breast-feeding, nor attempting to conceive, and - use a highly effective method of
             contraception as defined below, throughout the entire duration of the study and for at
             least 90 days after the last dose of ATX-GD-59. A serum pregnancy test will be
             performed at the screening visit in women of child bearing potential. Thereafter urine
             pregnancy tests will be performed. A positive result will exclude the woman from the
             study immediately. A highly effective method of contraception is defined as those
             which result in a low failure rate when used consistently and correctly such as
             implants, injectable, combined oral contraceptives, some Intrauterine Devices (IUDs),
             unless post-menopausal or surgically sterilized. Barrier forms of contraception are
             considered appropriate when used in combination with one of the above methods.

        Exclusion Criteria:

          1. Subjects who are pregnant or breastfeeding and/or subjects in the post-partum period.

          2. A known history of, or hypersensitivity reactions that in the opinion of the
             investigator would exclude the subjects' participation in the study.

          3. Treatment with any Anti-Thyroid Drugs eg carbimazole within the previous 3 months
             prior to Study Day 1.

          4. Previous treatment with radioiodine or (partial or complete) thyroidectomy.

          5. Signs of moderate or severe orbitopathy including optic nerve compression requiring
             steroids and/or a clinical activity score >3.

          6. Large and compressive goitres causing localised symptoms such as difficulty swallowing
             or breathing.

          7. Treatment with steroids (administered via the oral and/or parenteral routes) or
             adrenocorticotropic hormone with the exception of inhaled steroids within the three
             months prior to Study Day 1.

          8. Symptoms and signs of thyroid storm such as confusion, pyrexia with no other cause
             than hyperthyroidism.

          9. Significant cardiac disease and/or atrial fibrillation that would require urgent
             treatment of thyrotoxicosis.

         10. Prior treatment with biological or peptide-based therapeutics including rituximab.

         11. Prior use of disease related T cell vaccine or peptide-tolerising agent to treat
             Graves' disease.

         12. Detectable levels of antibodies in plasma specific for any of the peptides within
             ATX-GD-59 at the screening visit.

         13. A history of significant drug allergies.

         14. The use of any investigational drug, or participation in any Clinical Trial within
             three months prior to Study Day 1.

         15. Treatment with any cytokine or anti-cytokine therapy within three months prior to
             Study Day 1.

         16. Inadequate liver function, defined by a total bilirubin, aspartate aminotransferase
             (AST), alanine aminotransferase (ALT) or alkaline phosphatase > 3 times the upper
             limit of the normal values at Screening visit. 17. Subject with any significant
             medical illness or psychiatric condition that in the opinion of the Investigator,
             would preclude participation in the study or impair the ability to give informed
             consent; any other clinically apparent autoimmune disease.

        18. Clinically significant illness, as determined by the investigator, within 4 weeks prior
        to the first dose (Study Day 1) of ATX-GD-59.

        19. Known history of active or chronic infectious disease or any disease which compromises
        immune function (e.g. HIV+, HTLV-1, Lyme disease, Latent or active TB, Hepatitis).

        20. Major surgery in previous four weeks before screening visit. 21. Known osteoporosis or
        metabolic bone disease.