An Open Label Dose Escalation Study Of E7080
Condition: Solid Tumor or Lymphoma
MeSH terms: Lymphoma
Intervention: Lenvatinib
Intervention description: Lenvatinib tablets taken orally, once daily.
Intervention MeSH terms: Lenvatinib
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Intervention model: Single Group Assignment
Masking: None (Open Label)
Enrollment: 82.0
Sex: All
Minimum age: 18 Years
Healthy volunteers: No
Keywords: Resistant and refractory solid tumors; lymphomas; hodgkins disease; non-hodgkins lymphoma; neoplasms

Summary:

      The purpose of this study is to determine the maximum tolerated dose (MTD) of lenvatinib in
      patients with solid tumors or lymphomas.
    

Eligibility criteria:

        INCLUSION CRITERIA:

        Patients must meet all of the inclusion criteria outlined below in order to be eligible to
        participate in the study:

          1. Patients with histologically and/or cytologically confirmed solid tumor or lymphoma
             who are resistant/refractory to approved therapies or for whom no appropriate
             therapies are available.

          2. All previous treatment (including surgery and radiotherapy) must have been completed
             at least four weeks prior to study entry and any acute toxicities must have resolved.

          3. Aged greater than or equal to 18 years.

          4. Karnofsky performance status greater than or equal 70%.

          5. Written informed consent to participate in the study.

        EXCLUSION CRITERIA:

        Patients with the following characteristics will not be eligible for the study:

          1. Brain tumors or brain or leptomeningeal metastases.

          2. Any of the following laboratory parameters:

               1. hemoglobin less than 9 g/dl (5.6 mmol/L)

               2. neutrophils less than 1.5 x 10^9/L

               3. platelets less than 100 x 10^9/L

               4. serum bilirubin greater than 25 micro-mol/l (1.5 mg/dl)

               5. other liver parameters greater than 3 x the upper limit of normal (ULN)

               6. serum creatinine greater than 1.5 x ULN or creatinine clearance less than 60
                  ml/minute

          3. Uncontrolled infections.

          4. Clinically significant cardiac impairment or unstable ischemic heart disease including
             a myocardial infarction within six months of study start.

          5. Any treatment with investigational drugs within 30 days before the start of the study.

          6. Pregnancy or lactation (all women of childbearing potential must have a negative
             pregnancy test before inclusion in the study; post-menopausal women must be
             amenorrheic for at least 12 months). Female patients of childbearing potential must
             use adequate contraceptive protection, defined as two forms of contraception, one of
             which must be a barrier method.

          7. Fertile males not willing to use contraception or whose female partners are not using
             adequate contraceptive protection.

          8. History of alcoholism, drug addiction, or any psychiatric or psychological condition
             which, in the opinion of the investigator, would impair study compliance.

          9. Legal incapacity.

         10. Centrally located or squamous cell carcinoma of the lung.

         11. Proteinuria greater than 1+ on bedside testing.

         12. History of gastrointestinal malabsorption.

         13. Surgery involving gastro- and/or intestinal anastomosis within four weeks of study
             start.

         14. Patients with bleeding or thrombotic disorders.

         15. Patients using therapeutic dosages of anticoagulants.

         16. Poorly controlled hypertension (defined as a change in hypertensive therapy within
             three months of study start) or patients diagnosed with hypertension (defined as a
             repeat blood pressure measurement of 160/90 mmHg or higher) at screening.