A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of the Investigational GSK Biologicals' GSK3277511A Vaccine in Adults.
Condition: Respiratory Disorders
MeSH terms: Respiration Disorders; Respiratory Tract Diseases
Intervention: Formulation 1 (plain): NTHi/Mcat vaccine GSK3277513A; Formulation 2 (adjuvanted): NTHi/Mcat vaccine GSK3277513A; Formulation 3 (adjuvanted): NTHi/Mcat vaccine GSK3339036A; Placebo
Intervention description: 2 doses at Day 0 and Day 60, Intramuscular vaccination in the deltoid region of the non-dominant arm according to protocol schedule; 2 doses at Day 0 and Day 60, Intramuscular vaccination in the deltoid region of the non-dominant arm according to protocol schedule; 2 doses at Day 0 and Day 60, Intramuscular vaccination in the deltoid region of the non-dominant arm according to protocol schedule; 2 doses at Day 0 and Day 60, Intramuscular vaccination in the deltoid region of the non-dominant arm according to protocol schedule
Intervention MeSH terms: Vaccines
Phase: Phase 1
Study type: Interventional
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Enrollment: 120.0
Sex: All
Minimum age: 18 Years
Maximum age: 70 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Safety; Immunogenicity; Reactogenicity

Summary:

      The purpose of this study is to assess the safety, reactogenicity and immunogenicity of the
      investigational GSK Biologicals' GSK3277511A vaccine in adults
    

Eligibility criteria:

        Inclusion Criteria:

        applicable for both Step 1 ((healthy volunteers) and Step 2 ([ex-]smokers)

          -  Subjects who, in the opinion of the investigator, can and will comply with the
             requirements of the protocol

          -  Written informed consent obtained from the subject.

          -  Female subjects of non-childbearing potential may be enrolled in the study.

               -  Non-childbearing potential is defined as pre-menarche, hysterectomy, ovariectomy
                  or post-menopause.

          -  Female subjects of childbearing potential may be enrolled in the study, if the
             subject:

               -  has practiced adequate contraception for 30 days prior to vaccination, and

               -  has a negative pregnancy test on the day of vacci-nation, and

               -  has agreed to continue adequate contraception during the entire treatment period
                  and for 2 months after completion of the vaccination series.

        only applicable for Step 1

          -  A male or female between, and including, 18 and 40 years of age at the time of the
             Screening Visit.

          -  Healthy subjects without acute or chronic, clinically sig-nificant pulmonary,
             cardiovascular, hepatic or renal func-tional abnormality, as determined by physical
             examination or laboratory screening tests.

        only applicable for Step 2

          -  A male or female between, and including, 50 and 70 years of age at the time of the
             screening visit.

          -  Subjects without medical history, clinical finding or laboratory finding which in the
             opinion of the investigator could pose a safety concern or interfere with the
             protocol.

          -  Current or former smoker with a cigarette smoking history ≥ 10 pack-years.

        Exclusion Criteria:

        applicable for both Step 1 and Step 2

          -  Use of any investigational or non-registered product other than the study vaccines
             within 30 days preceding the first dose of study vaccine, or planned use during the
             study period.

          -  Concurrently participating in another clinical study, at any time during the study
             period, in which the subject has been or will be exposed to an investigational or a
             non-investigational vaccine/product.

          -  Previous vaccination with any vaccine containing NTHi and/or Mcat antigens.

          -  Chronic administration (defined as more than 14 days in total) of immunosuppressants
             or other immune-modifying drugs within 6 months prior to the first vaccine dose. For
             corticosteroids, this will mean prednisone ≥20 mg/day, or equivalent. Only topical
             steroids are allowed.

          -  Administration of long-acting immune-modifying drugs at any time during the study
             period.

          -  Administration of immunoglobulins and/or any blood products within the 3 months
             preceding the first dose of study vaccine or planned administration during the study
             period.

          -  Any confirmed or suspected immunosuppressive or immunodeficient condition, based on
             medical history and physical examination.

          -  History of or current autoimmune disease.

          -  Acute disease and/or fever at the time of enrolment.

               -  Fever is defined as temperature >= 37.5°C for oral or axillary route. The
                  preferred route for recording temperature in this study will be oral.

               -  Subjects with a minor illness without fever may, be enrolled at the discretion of
                  the investigator.

          -  Current alcoholism and/or drug abuse.

          -  History of or current condition preventing intramuscular injection as bleeding or
             coagulation disorder.

          -  Malignancies within previous 5 years or lymphoproliferative disorders.

          -  Pregnant or lactating female.

          -  Female planning to become pregnant or planning to discontinue contraceptive
             precautions.

          -  Any other condition that the investigator judges may interfere with study findings.

        only applicable for Step 1

          -  Planned administration/ administration of a vaccine not foreseen by the study protocol
             in the period starting 30 days before the first dose and ending 30 days after the last
             dose of vaccine, with the exception of any influenza vaccine which may be administered
             ≥ 15 days preceding or following any study vaccine dose.

          -  Laboratory evidence of clinically significant haematological (complete blood cell
             count [RBC, WBC], WBC differential count [lymphocytes, neutrophils and eosinophils],
             platelets count or haemoglobin level) and biochemical (alanine aminotransferase [ALT],
             aspartate aminotransferase [AST] or creatinine) abnormalities as per the opinion of
             the investigator.

        only applicable for Step 2

          -  Planned administration/ administration of a vaccine not foreseen by the study protocol
             in the period starting 30 days before the first dose and ending 30 days after the last
             dose of vaccine, with the exception of any influenza or pneumococcal licensed vaccine
             which may be admin-istered ≥ 15 days preceding or following any study vaccine dose.

          -  Post-bronchodilator FEV1 < 80% of predicted normal value.

          -  Diagnosed with a respiratory disorder (e.g. asthma, COPD, sarcoidosis, tuberculosis,
             bronchiectasis, lung fi-brosis, pulmonary embolism, pneumothorax, or physi-cian
             confirmed lung cancer). Please note that subjects with mild pulmonary obstruction
             (i.e. FEV1/ FVC ratio < 0.7 with FEV1 ≥ 80% of normal predicted values [GOLD grade 1])
             can be enrolled.

          -  Has contraindication for spirometry testing (such as recent eye surgery, recent
             thoracic or abdominal surgery procedures, unstable cardiovascular status, recent
             myo-cardial infection or pulmonary embolism).

          -  Laboratory evidence of clinically significant haematological (complete blood cell
             count [RBC, WBC], WBC differential count [lymphocytes, neutrophils and eosinophils],
             platelets count or haemoglobin level) and biochemical (ALT, AST or creatinine)
             abnormalities.

          -  Has significant disease, in the opinion of the investigator, likely to interfere with
             the study and/or likely to cause death within the study duration.