A Comparative Bioavailability Study of Lomitapide 20 mg Intact vs Sprinkled
Condition: Healthy
Intervention: lomitapide
Phase: Phase 1
Study type: Interventional
Primary purpose: Other
Allocation: Randomized
Intervention model: Crossover Assignment
Masking: None (Open Label)
Enrollment: 32.0
Sex: All
Minimum age: 18 Years
Maximum age: 40 Years
Healthy volunteers: Accepts Healthy Volunteers
Keywords: Comparative; Bioavailability; lomitapide

Summary:

      To compare the relative bioavailability of lomitapide when administered by sprinkling the
      contents of a 20 mg capsule of lomitapide in applesauce or in mashed banana to a single oral
      intact capsule dose of 20 mg lomitapide in healthy subjects.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Subject is a non-smoking healthy male or female, aged between 18 and 40 years of age.

          2. Subject has a BMI of 18.5 - 25 kg/m2.

          3. Subject has total body weight between > 50 kg to ≤ 100 kg.

          4. Subjects must agree to use acceptable methods of contraception.

          5. All females, regardless of childbearing potential, must have a negative serum beta
             human chorionic gonadotropin pregnancy test at Screening and on admission.

          6. In good health, determined by no clinically significant or relevant abnormalities
             identified by a detailed medical history & full physical examination.

          7. No known history of hypersensitivity or previous intolerance to lomitapide,
             applesauce, and/or banana.

          8. Subjects must be capable of understanding and complying with the requirements of the
             protocol and must have signed the informed consent form prior to undergoing any
             study-related procedures.

        Exclusion Criteria:

          1. Subject has a clinically significant disease or any condition or disease that might
             affect drug absorption, distribution or excretion.

          2. History of stomach or intestinal surgery or resection that would potentially alter
             absorption and/or excretion of orally administered drugs.

          3. Any clinically significant abnormal laboratory, vital signs or other safety findings
             as determined by medical history, physical examination or other evaluations.

          4. History of significant hypersensitivity, intolerance, or allergy to any drug compound,
             food, or other substance, unless approved by the Investigator;

          5. Electrocardiogram (ECG) abnormalities in the standard 12-lead ECG (at screening) such
             as a QTcF interval of >450 msec, a history of a prolonged QTc interval or Brugada
             syndrome.

          6. History or current evidence of any clinically relevant cardiovascular, pulmonary,
             hepatic, renal, gastrointestinal, haematological, endocrinological, allergic,
             dermatological, metabolic, neurological, psychiatric or other disease.

          7. History or laboratory evidence of Gilbert's syndrome.

          8. Positive results in any of the serology tests for Hepatitis B Surface Antigen (HbsAg),
             anti-Hepatitis core antibody (anti-HBc Ig G [and anti-HBc IgM if IgG is positive],
             Hepatitis C antibodies (anti-HCV), and HIV 1 and 2 antibodies, (anti-HIV 1/2).

          9. Use of any drugs of abuse within 6 months prior to admission.

         10. Confirmed positive results from urine drug screen (amphetamines, benzodiazepines,
             cocaine, cannabinoids, opiates, barbiturates and methadone) or from the alcohol breath
             test at screening and on admission (Day -1).

         11. History or clinical evidence of alcohol or drug abuse within one year prior to
             admission.

         12. Mentally handicapped.

         13. Participation in a drug trial within 90 days prior to first drug administration.

         14. Use of any prescription medication within 2 weeks prior to admission (Day -1), with
             the exception of the oral contraceptive pill.

         15. Use of any substance inducing or inhibiting CYP3A4 enzymes within 30 days prior to
             admission (Day -1).

         16. Use of any over-the-counter (OTC) medication (including vitamins, minerals, and
             phytotherapeutic/herbal/plant-derived preparations) within 7 days prior to admission
             (Day -1), unless deemed acceptable by the Investigator and Sponsor.

         17. Use of alcohol-, grapefruit-, starfruit-, or caffeine-containing foods or beverages
             within 72 hours prior to admission and through Study Completion.

         18. Donation of more than 500 mL of blood within 90 days prior to drug administration.

         19. Receipt of blood products within 2 months prior to admission.

         20. Poor peripheral venous access.

         21. Use of any tobacco- or nicotine-containing products within 6 months prior to admission
             (Day -1).

         22. Any acute or chronic condition, scheduled hospitalisation (inclusive of elective
             surgery during study), or scheduled travel prior to completion of all study
             procedures.

         23. Any circumstances or conditions, which, in the opinion of the PI, may affect full
             participation in the trial or compliance with the protocol.

         24. Legal incapacity or limited legal capacity at screening.

         25. Subjects who are vegetarians, vegans or have any dietary restrictions conflicting with
             the study standardised menus.