Study to Evaluate the Safety, Local and Systemic Tolerability, and Pharmacokinetics of Multiple-Dose Topical Administration of PF-07038124 in Japanese Healthy Participants
Condition: Healthy
Intervention: PF-07038124 or vehicle; PF-07038124 or vehicle
Intervention description: PF-07038124 0.01% or vehicle Ointment QD applied to 2000 cm2 Body Surface Area; PF-07038124 0.01% or vehicle Ointment QD applied to 4000 cm2 Body Surface Area
Phase: Phase 1
Study type: Interventional
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Enrollment: 12.0
Sex: All
Minimum age: 20 Years
Maximum age: 55 Years
Healthy volunteers: Accepts Healthy Volunteers

Summary:

      The purpose of this study is to evaluate the safety, tolerability, skin irritation potential,
      and PK of PF-07038124 in Japanese healthy adult participants.
    

Eligibility criteria:

        Inclusion Criteria:

          1. Male and female participants must be 20 to 55 years of age, inclusive, at the time of
             signing the ICD.

          2. Male and female participants who are overtly healthy as determined by medical
             evaluation including medical history, physical examination, laboratory tests, and
             12-lead ECG.

          3. Participants who are willing and able to comply with all scheduled visits, treatment
             plan, laboratory tests, lifestyle considerations, and other study procedures.

          4. Participants must have 4 biologically Japanese grandparents who were born in Japan.

          5. BMI of 17.5 to 25 kg/m2; and a total body weight >50 kg (110 lb).

          6. Capable of giving signed informed consent, which includes compliance with the
             requirements and restrictions listed in the ICD and in this protocol.

        Exclusion Criteria:

          1. Participants who have any visible skin damage or skin condition (eg, sunburn,
             excessively deep tans, uneven skin tones, tattoos, scars, excessive hair, numerous
             freckles, or other disfigurations) in or around the application site which, in the
             opinion of the investigative personnel, will interfere with the evaluation of the test
             site reaction.

          2. Participants who have a history of or have active forms of dermatitides/eczematous
             conditions (eg, contact dermatitis, seborrhhoeic, discoid, gravitational, asteatotic
             and dishydrotic eczema) or other inflammatory skin diseases(eg, psoriasis, viral
             infection, fungal infection, bacterial infection) that would interfere with evaluation
             of the test site reaction.

          3. Evidence or history of clinically significant hematological, renal, endocrine,
             pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or
             allergic disease (including drug allergies, but excluding untreated, asymptomatic,
             seasonal allergies at the time of dosing).

          4. History of HIV infection, hepatitis B, or hepatitis C; positive testing for HIV,
             HBsAg, HBcAb, HCVAb, or syphilis at screening. Hepatitis B vaccination is allowed.

          5. Other medical or psychiatric condition including recent (within the past year) or
             active suicidal ideation/behavior or laboratory abnormality that may increase the risk
             of study participation or, in the investigator's judgment, make the participant
             inappropriate for the study.

          6. Acute disease state (unstable medical condition such as nausea, vomiting, fever or
             diarrhea, etc) within 7 days of Day 1.

          7. Have undergone significant trauma or major surgery within 4 weeks of screening.

          8. Use of prescription or nonprescription drugs and dietary and herbal supplements within
             14 days or 5 half lives (whichever is longer) prior to the first dose of study
             intervention.

          9. Previous administration with an investigational drug within 4 months (or as determined
             by the local requirement) or 5 half lives preceding the first dose of study
             intervention used in this study (whichever is longer).

         10. A positive urine drug test at screening and/or Day -1.

         11. Screening supine BP ≥140 mm Hg (systolic) or ≥90 mm Hg (diastolic), following at least
             5 minutes of supine rest.

         12. Baseline 12 lead ECG that demonstrates clinically relevant abnormalities that may
             affect participant safety or interpretation of study results (eg, baseline QTcF
             interval >450 msec, complete LBBB, signs of an acute or indeterminate age myocardial
             infarction, ST T interval changes suggestive of myocardial ischemia, second or third
             degree AV block, or serious bradyarrhythmia's or tachyarrhythmias).

         13. Participants with ANY of the following abnormalities in clinical laboratory tests at
             screening, as assessed by the study specific laboratory and confirmed by a single
             repeat test, if deemed necessary:

               -  AST or ALT level ≥1.5 × ULN;

               -  Total bilirubin level ≥1.5 × ULN; participants with a history of Gilbert's
                  syndrome may have direct bilirubin measured and would be eligible for this study
                  provided the direct bilirubin level is≤ ULN.

         14. A positive COVID-19 test at screening.

         15. History of alcohol abuse or binge drinking and/or any other illicit drug use or
             dependence within 6 months of screening. Binge drinking is defined as a pattern of 5
             (male) and 4 (female) or more alcoholic drinks in about 2 hours. As a general rule,
             alcohol intake should not exceed 14 units per week (1 unit = 8 ounces (240 mL) beer, 1
             ounce (30 mL) of 40% spirit or 3 ounces (90 mL) of wine).

         16. Blood donation (excluding plasma donations) of approximately ≥400 mL within 3 months
             or ≥200 mL within a month prior to dosing. Additionally, approximately ≥400 mL within
             4 months for female participants.

         17. History of serious adverse reactions or hypersensitivity to any topical drug; or known
             allergy to any of the study intervention or any components in the study intervention
             or history of hypersensitivity; or allergic reactions to any of the study
             preparations.

         18. Not willing to refrain from shaving (Note: shaving around face is permitted), the use
             of depilatories or other hair-removal activities, antiperspirants, lotions, skin
             creams, fragrances or perfumes, or body oils (eg, baby oil; coconut oil), use of hair
             products, hair gels, and hair oil in the treatment areas for 48 hours prior to
             admission to the CRU and for the duration of the stay in the CRU.

         19. History of sensitivity to heparin or heparin induced thrombocytopenia only if heparin
             is planned to flush intravenous catheters.

         20. Unwilling or unable to comply with the criteria in the Lifestyle Considerations
             section of this protocol.

         21. Investigator site staff or Pfizer employees directly involved in the conduct of the
             study, site staff otherwise supervised by the investigator, and their respective
             family members.